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<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1V9</accession>
    <name>A0A0N5B1V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1V9"/>
    <dbReference type="WBParaSite" id="SPAL_0000006000.1">
        <property type="protein sequence ID" value="SPAL_0000006000.1"/>
        <property type="gene ID" value="SPAL_0000006000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893865" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000006000.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31820" checksum="A6FF306F1B0975D1" modified="2015-12-09" version="1">MRNVLLIFCFLLLVTKDISIKGFSYKNFISEIFEIEVNLTLHVKDSYNANSNLDVDLVVGGYLHDDLESSRNESKYTKREEKEKLYRSLLTGNCILFASNFHLKNDESEHKTSSKSHESEHKPFSKIGTTYNKTLKSSEFGFVNEECIFWGNYDKLNVDDFKEYFNRINLCIPTVDFFAFYTKGSSHSPELVFDQLKISISIKPNDEFLGGCGKLCDKLKKALKNNDVNYEMNDDDEMVLDDATVQKFTRNDRKYIMEPTIRGDVNEIIFNCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2A8</accession>
    <name>A0A0N5B2A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B2A8"/>
    <dbReference type="WBParaSite" id="SPAL_0000021000.1">
        <property type="protein sequence ID" value="SPAL_0000021000.1"/>
        <property type="gene ID" value="SPAL_0000021000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF119">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="2">
        <location>
            <begin position="2333"/>
            <end position="2369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000021000.1"/>
        </source>
    </evidence>
    <sequence length="2422" mass="283871" checksum="D891F6AD69BC55A9" modified="2015-12-09" version="1">MDNDDERSVNLEGNLINDFSSLGDVINDVIRDDLVTTHPKVKNLVKNIRKITNLTEQFPNWIEMCYELIKTDLFYSSRILGERCYRKIYNQFFKIASKDDIKGWCTFISDNIDNLLRDEEMLTCCIKALNEQKIDGNNLEDVNSRFDSILYIFRSDDYTLGRNTFLKYLRLLNHLTIIFEKKTGSIEGLEIWRTSDTFNFLISYAMDYTTDNEIQEAFFVSLKFFKIYWKEDQESTKSLGITIYNDMIAYMNSLEDGQSFGPVNCLYRVTSKIIDSLDFENLLEFFDNVVDSKKIIKQMDIWRCNESLLKIFLLLSCSKETLDEVTRFKIMSSFFDCLNDPNGEVLIYILEMRSHLPKEKVYEYISKLTDDYVLYQMWDGNKFSDKKSIEVMSDIINDVEEASSMILYKEITKKVSNIVSILQKNDIDKDICRERERIVVYFLRILEKLFTKKHNIMVFMSYQPSFFNFLFKDLTIPWRNVKRMSKEFIFYVVTIQRGFSSLYDHYISNYVWEEEGGSNNSSILQLSLSSKYFGDKAYFYKYGPYTQEEESLAVNLINGAQLLLERCQWHLNNYGMPRLQKLFLQLIRKCDHTQFIYLMKIVPSTFVLSYSLNRGYLPPEQKFTNSTCFVTNRQDFIRVMDFVYKKIDMGINFQRDIFLKWVERPTDIFNADCVGIKYSMEYWNLICVGIAMYLYNEQFITPVGCMWKTLLFMEETSTVLLTEINESLGIESSDGDDFINYKLDLQEEMIEKAKKMDASVEGNLNVDYEYSFEYEGMDHIYSDRKPLYEEAILRFSLWIKIIFNVLRCFEVSPKDITEPKGDDKVVRRNIFIRENEYELRKAFNRIVVPIIKISYRIGHYADPRDFYDSQKVDVPDDVKAKINEILPLMANSYLKTSSSQSLKGMKKYFETTFGSYNLNWIDDIENIVQGKLEKGLGNLEIRKNIFYQNYIDEMINEVTGILNYYKDGRKVNKESLCDIEDDKKSDNSYRKKKDRIRKKKKNDKLLNSLNNWDCIPKEPVDDRNIIYDIKKFTNAIEGNVLATYECFIDLRNVALKKYNKILWKSSELLQTIGHYALTLQSNSRLFSSAYCSHLITEDVKKRLTLRLNKIPFSEDIELPLNPIECLEIGKKLSWWLNHCGHYIHASISSAFYLDVAKMAIKTDNEHLAKDQLYLFKKTFSKISKYDHPLESLNGSMTTLDYDIKFKDKEITFKHLNYITKSVSLFMDHLFEKSPIQRIVMPNIDMIEGEIDQLNILPETISKTTYYKRHLDHQTKMYGISKAIIKMGRIAVHSNDNIQKFTETLADSTQTQMIHKLVKPYIKNYHAMIEYTDTTSSIIYPSFLTLSTKFSPNYAKPYLLMAEYAFNKGTKGISEQLPVTANEENQLKHHLHFMHEYFDNEDFNRLYNIVLSTNTTISLRTNIISFIKQFPLYRSEAEIFADNIMKDSLFISLFTKICTRQAKFFTIATKAYEQYLSLCSTPYISSDIIKSVLNIYKMIILCPPVISRLVSSILKKVNEDVWKNILPQLFPRLSHPNRFVRECIYNILESVAKTSPHVLVFPIVVARNNVRDEDMYFNTMNKAQFNSINSVSKEKEKLFIAEYCTRLSNFIEEKYPGLIGSVTKFVDELKKINMLIDDKWVYVLSKCDSEMKKKLSSYCNYLKKGSDQRISPNERMTIGKEKYKILTNIIYQALNDLYDITFNKKFESDYEENFVTNYGKMIKDAFEQYNALKSESDPFRAFIPFQDLLKDLNESLYNMKGGIVPLPGQDMKRYCDPSFVSIEKVSNVVTVIQSLTRPKKVEFHGNDGSSHYYLVKGYEDMHLDERLQQILRICNQILDNKKYKVPGDLEYPYRAKNYSVTPIGARSGLIKYVGEADQMFTPYYNWLQKNKDKFDGEVPEDVNASKKARQYFIGRVKKYLNCNNDKITDINEFRLKENTESFVKAFNDVSDIVPKDILTNKIQKVVVDGDHWYHVTKTYSRSVAVMSMIGWLFGVGDRHLSNIMIIYLTGEILHIDFNVCFGKLKNLKCPEKVPFRLTRSMVDVMGPMKTEGIFKESCKYVLRCLKEDYEILYNILDTYAYDPLADWSSVSEVKYQGESLPLDIMFAIYGRSVFEPKALVERSSGLFKVKIMEISLMINDYENMAYEVISELIDIYTKENQSPGSWVNGAYTSQMTSYKFHSIQKPLESFATIIKGPLTALSVYNNQFNELERLLYHELIPKVKKTCMLTMPQEYNYELNCERIRMLNEVMELSKDCIKKLKELSTIEVVFNEESMYSLKRDSRHCDVSSQMKNECAVSIINDVKSRFNKLFYGNVQENDQSSNDNNVIKKAENNDVVENRLDNLISDLIDEATDVNNLAVMFEGWAAWVSLRSSIIIDTKSYVVFYLCKLLYNLLRFMKSKGYLWIKFTEILTKTMVFSYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2C6</accession>
    <name>A0A0N5B2C6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-dependent RNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2C6"/>
    <dbReference type="WBParaSite" id="SPAL_0000023300.1">
        <property type="protein sequence ID" value="SPAL_0000023300.1"/>
        <property type="gene ID" value="SPAL_0000023300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000023300.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9980" checksum="595D5A07B90E0AAD" modified="2015-12-09" version="1">YKGSDRALHSNEIYISSKSIKNIHLVSGTENVDWMANASRSSSHCELESLVLKGIFTGFLTADSIEFVVSIVRYFKDIQFPLHYTGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2L2</accession>
    <name>A0A0N5B2L2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2L2"/>
    <dbReference type="WBParaSite" id="SPAL_0000031800.1">
        <property type="protein sequence ID" value="SPAL_0000031800.1"/>
        <property type="gene ID" value="SPAL_0000031800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000031800.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16634" checksum="9807AC5117D8DDC9" modified="2015-12-09" version="1">MNTAANSGVTLKLTNEEAEKLIKFLINHPKFNDFTPRERRSYETDDPSEFLNIIEKLEDNLKNTCKIIRSFIKQSEQNNNDISKMIDAERQDMENCFSFLNERISIIQRLVNDKIVELVGKLPINDENPNYSTSDSTNDDVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B328</accession>
    <name>A0A0N5B328_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B328"/>
    <dbReference type="WBParaSite" id="SPAL_0000047900.1">
        <property type="protein sequence ID" value="SPAL_0000047900.1"/>
        <property type="gene ID" value="SPAL_0000047900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893679" evidence="2">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000047900.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19054" checksum="E0D91F31D29BBA9D" modified="2015-12-09" version="1">MVKLSISVILFFNLVNYSYSTKDLIADKINKLDEAPLEVKDPATKEIAKMISSTMKFIDLPLELGNNENYVKNKPFVKERLRQNLKMIGLLSAQINDNLLPFITQDFGDLKSKKENMDNKLLDKVPGPSGRFPLFPFPFPWTRPRPQPQPTEKDGKPPIVFEPYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Z3</accession>
    <name>A0A0N5B4Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0000114066.1">
        <property type="protein sequence ID" value="SPAL_0000114066.1"/>
        <property type="gene ID" value="SPAL_0000114066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000114066.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24999" checksum="B14925514BFE5A33" modified="2015-12-09" version="1">MAIRAAIAGYNSSRKETIDKIKLAERKKWPLLINNIAQALNSVRNINELTPYDKFSTNIKNANPTIVYELSGALFKKFVNAEGHKVLRLKINTSIQISFTISSNIVAEPRLVTVVILTANELVNNLKSNCDNDSVKGSKKRLFKAISVLRSKHKISRKLKIRTKITVLDATISSRFKSEKKKSELDPDVTYDYFNTLAEPKKVINGCEWLKSNKWFLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Q2</accession>
    <name>A0A0N5B5Q2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-serine(in) = L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:35031"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Q2"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Q2"/>
    <dbReference type="WBParaSite" id="SPAL_0000139800.1">
        <property type="protein sequence ID" value="SPAL_0000139800.1"/>
        <property type="gene ID" value="SPAL_0000139800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF20">
        <property type="entry name" value="SIDEROFLEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000139800.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37935" checksum="181D67A69C554C8C" modified="2015-12-09" version="1">MPIITKFLTDEQGDLKISQLSSPLDLSQPRFDQSTFTGRLKRFFGIINPFFLTFSSSYLEKCKKTVLDYKNGKYDPNMTVDELWTAKRHYDSAYHPETGEKTFVLGRMSAQAPCNAFIKGGMLTFYKNPYAVFFWHYLNQAHGAMLNYCNRSGKAGSGDNVRLMTAFACATTVGVGTALSLNRIVGNMKLPPLVNRFVPFIASSIAMSTNIPIMRQREFIEGIAVKDENNVILGRSVVAAKWAIGTVALSRILMAAPYMLLSPVIMDIISKTKFYNRNRWVSGPIQCFLTFVILSISAPIGCSVFPQNGEIAVSSLEPELQEKISKHSKSLTVVRYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6K7</accession>
    <name>A0A0N5B6K7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6K7"/>
    <dbReference type="STRING" id="174720.A0A0N5B6K7"/>
    <dbReference type="WBParaSite" id="SPAL_0000169500.1">
        <property type="protein sequence ID" value="SPAL_0000169500.1"/>
        <property type="gene ID" value="SPAL_0000169500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000169500.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="47436" checksum="B82531F92B60FE80" modified="2015-12-09" version="1">MDNFLDEFEWLYKGLNTRFLADRQYEWIPQIWIDYFENIDFVDCKQLKNAPDDLIKFIERTKELSVLKDYSSIKISKENEKLYTTIYGKNVKNKKLSEILGMGELISRYCEKYNITRVVDVGCGVGYLLRSILLYSPNLECIGVECDEILCQKAREKSSNINIIRLRLNSECDKNVLKDIFSPPNHSTAIICLHGCGDLQKTIIDLYLSLNEDFNPLLITVGCCYHKMKNYDENLTKYIKWNTTALRLACQERISKFMHFSAEDHTKHVGNFLERAKLECLYDFIGVKREDMSRNFARKLKYEDLKNLDDVKNLFKNVDIIVNNIDKESYDEKLREIDGVSERVKHLIEPFTMLQYYMQAVLETRLLTSRIDYIKSRTKNINISLIPISDSVSSPRNMAIVAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6M5</accession>
    <name>A0A0N5B6M5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein LEE1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6M5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6M5"/>
    <dbReference type="WBParaSite" id="SPAL_0000171300.1">
        <property type="protein sequence ID" value="SPAL_0000171300.1"/>
        <property type="gene ID" value="SPAL_0000171300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000171300.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53725" checksum="E037BBCB25DBEFFD" modified="2015-12-09" version="1">MFHGTSNTMEGNYIGSPSPGFPISTPSLQAPIGYVPQLPGTMSPYPTGPALVSPVYYVSSLSSPLQQISSVVYMGNNCSSTANNSLKNTIESPSTSTYYDSKNPENTTSSKNDINNSSNTSPEPVDKETEVSPCSKNSPIDETSSTLLVTDRFAVKLEPNKFIHGVPATKWYTLSDEERNTVIRNQRRIISYKTALCTSYRAKGTCSFGENCRFAHSLDELKPPPVRHPKYKTQLCDKFSATGICPYGSRCNFIHATKSGQIVSDYPKYLACLQKEALNNDIYDDYDDDKKAPFALSMSAIPRKYSLNERIELTSGKLSADEKPQQVINFSKSFGTPMVKTIFRNGKLLKNNIKEKNDNEMDNDSKCALHGYDKGSTTSSLSRTSSRTSSSSKMSEKKERSVLEKLFTESYKFKSFKKEVMERTSYIDEDDSSDSNEIDENSPPGSQSYTNGYWKGNSSRRYNYGFYSQSEVPKFLRFDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7F9</accession>
    <name>A0A0N5B7F9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7F9"/>
    <dbReference type="WBParaSite" id="SPAL_0000198500.1">
        <property type="protein sequence ID" value="SPAL_0000198500.1"/>
        <property type="gene ID" value="SPAL_0000198500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF65">
        <property type="entry name" value="NOSE RESISTANT TO FLUOXETINE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="757"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000198500.1"/>
        </source>
    </evidence>
    <sequence length="821" mass="94517" checksum="095A3E3FD80BAB6B" modified="2015-12-09" version="1">MKLITSLHIFLYLILLSSSSFGRRIEFNNHEWEEGIEDEEVEGNILYNMFRDSNTILSLELDIFKDIIAGFLNATESAKDGDGSSMLKILDLLQPIKNLDISPNCVADIFYYGYITTQYARMVNEKKSCNDCICKANVSKYFDEYEWIFDVVDAMGKVPSAVMSGNNLWIGSWHTCRKIDVTKNINQKWKGQYCKLQFQPYNRNNPLSQMASTTQPDPTESCAKVKNITKPPEWSDWDNECFTMLPLLNFGICVPDTCTEYDVKSILQFFYKKIEGLSGSKLICNVNVACSSEKAENNITSDRTSMFVVYFLTAILATIIFGTFYDIYVHQPSISIYGTPQIDSWFIHLLLAFSIYSNGKYVLAKNKLTDQIDCLHGARVLSMMWIILGHTYWYICTSLTADNVLQTLKNFPKIFHNQIVIQAPLAVDSFFLLSGMLTSYLFFKKTMPPKLDKDGNVISKHTINVKSFTFWVVFYLRRYIRLTPVYVVVMILNTTVLTHLSNGPFWRPIELNYCRKSWWTNLIYMNNFLLQDVEQCMGWSWYLANDFQLYAISPLYMLLINYNEKLGIIGCIGTIIVSSICRLIITLIKGYPPGPILTTKLQIVGLIDEFWTNVYIKPYARCGPYMVGLVVGYYLYKYKLKLETQKWKIYLCWCLSTCMGFYSVFGMYPYSSTGEITKFHLIFYTLFGGPMFSLSLGWVIFACSTGNGGIVKKILGWKAFVPLSKLTFCTYLMHPIILQLYNFSRPHPFHFTSTFQMLTLFSVAATASYFVAFFIACAFEFPVTYLDKLLFDRRDKKKGDVVGHDEVKDSLLSKEDKLQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S4</accession>
    <name>A0A0N5B7S4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B7S4"/>
    <dbReference type="WBParaSite" id="SPAL_0000209900.1">
        <property type="protein sequence ID" value="SPAL_0000209900.1"/>
        <property type="gene ID" value="SPAL_0000209900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46068">
        <property type="entry name" value="PROTEIN CBG27172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46068:SF1">
        <property type="entry name" value="TRANSPOSASE IS30-LIKE HTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209900.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20710" checksum="1AF78E7A83D57E30" modified="2015-12-09" version="1">MSCPCRDAIARLAKSGMKNSAISSKLGVPLRTVQKIVKQWREEXRIERKDDRSLNKMAKELKISRKSVQMIVKNELGLRSYRSLNGQVRRIEDVLWSDEKIFTVEVAKNSQNHRQHLSPALKNTRKRKIGTRSQFPKSLMVWGGISASGKTPLLFIDKNVKINSKIYQEEILKKAVVPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B871</accession>
    <name>A0A0N5B871_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B871"/>
    <dbReference type="WBParaSite" id="SPAL_0000224400.1">
        <property type="protein sequence ID" value="SPAL_0000224400.1"/>
        <property type="gene ID" value="SPAL_0000224400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733391" description="UDP-glucuronosyltransferase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000224400.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60161" checksum="BE23190B312A370E" modified="2015-12-09" version="1">MNIFGLLLLFSSFLNSLSYKILLYNPKFSYSHVNFVSKISDILVEAGHDVTVIVTEMDLNVKHPGTRKGKIYLASSHPRTIELMTNNILFVDMWNTTNDFSRQIEMMNRFMEASNIQARHTFHDKELENFVISQNFDIAFSELLHSHMFGLFKIWGIKVHVSGCATALFDGMYGPFGLPFPSSYVPNLMNPYTDRMNYKERFNNVIANLMNKLYIILKGREMVLQDLFDQKCGKGICDIRELVGDSAFVLINTNPLFNLPGAKTPKMIEVGGIAISDPAPLDDFWNKVLSYRQKTVFLSFGSIAKSSFMPDNFKKSILETVKNLSNITFIWKYENPEDGIGDGIDNLILSKWVPQSDLLNDGRISLFITHGGLNSLTELAYLGVPALAIPMFSDQFANSKLLERARIGESMSKDEIKYPNKLISKITSMINNDEYKNNSKRLSKMLKNYPFNAKQQLKKYFEFAAEFQKLPMLDLGSRNMTTIEYYNIDVLVPIFLVIALILFSVIYGIRQIFKLTKRSFLKIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8U9</accession>
    <name>A0A0N5B8U9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8U9"/>
    <dbReference type="WBParaSite" id="SPAL_0000247200.1">
        <property type="protein sequence ID" value="SPAL_0000247200.1"/>
        <property type="gene ID" value="SPAL_0000247200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893934" evidence="3">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000247200.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17555" checksum="6C0880D3D31604ED" modified="2015-12-09" version="1">MKFLIYLGFIFGMLQSILSDDCKDLSSNCRNNLKHCRNSIYGPIMKKNCAKSCRYCIPPTRPTFAPILRDRIRNCSAMIERCHQKEYIFYMEKNCKKTCSTVTPKRETTTIAPEENTTITLEENSSKSAEVIEGSGTVNGDNNNEEFDITGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9N2</accession>
    <name>A0A0N5B9N2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B9N2"/>
    <dbReference type="WBParaSite" id="SPAL_0000274800.1">
        <property type="protein sequence ID" value="SPAL_0000274800.1"/>
        <property type="gene ID" value="SPAL_0000274800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20814">
        <property type="entry name" value="CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="9">
        <location>
            <begin position="812"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="877"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="101"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000274800.1"/>
        </source>
    </evidence>
    <sequence length="1317" mass="152563" checksum="E09D875421A6AAF6" modified="2015-12-09" version="1">MANETQYFELGEDFSSAQQPSSSSHREESGRNVNDDYFNTVTNITIGHKSATKDLNESIDIEYVVEKNQEQQEIICDLRKQLSHIHDAQKTSESTLIELAEKLSSKQYKVANENLRELKNRYRNLVTQEKYVREMLRIETDKSNKYKDEVERKKEQLLEATEIISKLKDKTEELKHKLKVGERSNEANELNHCKQEISKLNTEIMRTNRILKIRESEMANLQRHYNDTESELSSHIEELQKALEDTQKKYRNHLDECLSSGNQQRGIESGEYMEKLQQELGSLKTTNTYLEKEKQQLCEDLEKVKIELNLCRDDVKSLVNEKNSLTEKMENIQGDHQLTSQFLNEQNEKLRESKAKIRCDLVLLKREHQSLVDEHKECLEYKVMSGNLKERVESIEDQNKKLESELERLKSENESLRKEIGNKERSVSEIQAKYDALSTTMQTIEKEDVSQKEELKKEILKLRRELSLNEETLKTLDAQCDSLAKNNKSLKESRKVKSEEIMNLKNEIEMWKHKEASFNDLKIEKIKLEKKVEFLEEELRETTEDYKNEIRDLAASLQNAKLRENSESSLEMKDRLDTLERERVQLESQIRCFQRQVDNLKKELKDREDELADKKSVQSKYTEEHEEVLNGLKLAIEKCERYKNENETLKDLLQNKESTMKSFTDKQNELESEIFELKEDIEQKDKLIVYLQSQIQIKQLPKLKYNPSSATLISNPEADSYEGKSKENYGTSSFSFKNSRTKSQVLSDSSGEKNVLQTMSKSYTYHNVSSSSKEKPFVTLTPSKMPKDDPQNEGKSNDVMERSIGTMRHNIPHRWKLFFAIKQVKCDHCGDGLSRLRYANRCTECGVNVHVKCTRRMPNTCGLPTDCAKFYMDTKSGNGMMGWVKLLISTSTSKHEKWEKYFAKLRNGTLRFFDEENLASDNDEAHLVVDLMREQWKFYQQTGQAVNGVENEAMKRLIEIKLPGFNIFMLSPTEQAKQRWVKALQSINNRQQGQRKNKSGGGTDVQMLLCLDSPQNLAINATIIFDDYLVIGANEGLFATQLQNGRMPFSIAGVTSVQIMEIIPELNMLIIVCGHHKQLSIVHLSQLRSSFVNPRNGVNPTPVCNLRNCHIMVVSPPDHNTSRHLYVATMDAIHILQHNKKLDMFNVIKVIRTKEPCNSILSIPGGFVYAADTFYFVNNNDQSEKSLDVSDYVEDYPLEALFVGDDEILLAFHNYGIFVNTKGQRTRASNVEWPQVPLCFVYCNNYLFIAHYDSLEIFKIAPVGDFNDTTQPIVKYVEEYKCSNVQFTGYGKTKKEVLFSLSSDVRVEVHKFTCNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Z3</accession>
    <name>A0A0N5B9Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0000286200.1">
        <property type="protein sequence ID" value="SPAL_0000286200.1"/>
        <property type="gene ID" value="SPAL_0000286200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000286200.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35317" checksum="DDB06C9B7A9E2876" modified="2015-12-09" version="1">MNLLNLMEKFLITGDFPEKLPKVYSKSFLLVNMLSPATKYMTHELAYQVTYAVGKLLNSIPENVYDRDNVHDFAEFFAYTGLKIARSMFDINVMEELTLILKKILRCFEEEARCILLKRAFSRFLDQTEGGDNQLPYEANMSAIFIDFYRQEIGKAKIFEEELIDLWSIILTRHYYDFDRGAATYYNAIMMLIKLQCNAKLCVKLLKNTISSSYYKTVEENLSLFCFKREIEVNDMREKAEEMKNKMPGRFKTKECKGEELQNIKESPYVGVLRYSIATTKTDLNRLIYGDNFQRDNVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA72</accession>
    <name>A0A0N5BA72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA72"/>
    <dbReference type="STRING" id="174720.A0A0N5BA72"/>
    <dbReference type="WBParaSite" id="SPAL_0000294100.1">
        <property type="protein sequence ID" value="SPAL_0000294100.1"/>
        <property type="gene ID" value="SPAL_0000294100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF3">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="401"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="632"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000294100.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="86050" checksum="2DC00F5659D06E02" modified="2015-12-09" version="1">METQQEISNSGTKLLQSINAQKFFNKNHPEYARQFSFELYKTVNSKNQFFNHVNHYFDYIKNLNNENNLSGNFSKSRFNGSKVTSNQKLFRKIVVHSFYLFYDMNKSEKNRNLDLPKKKSSFKKNKINFSLEISDHITILEIICLKAHDDKNSLIKLHMSNFELLKSREHLCSEIYNFINSGKYYFQILNFMLTDKGNFPFVNSPKLFEKLAFLGPIHAKSLEEIVDSKDETFFEDTVKILKQLRCYMENFDLFEDFYTNTIRRKAKPEYFYIFRENVKNLFTRLKRENIQKEPIPMSTASIQLKRHLKMRYHQKIIDNHYLNDVAYIIICQHPSLKSTLENFLEKEKDYEELGKWKSLPIEKNPFPQFFPFEDKTGDDLYAEKPGFLALPNAIQVKVCLSNEEITEAIMDIKNANKAGFTIVGFDCEWSPFSANQNVSLIQVSLNNICYIIDAAYGDRELIGKFLEELFSAKHLIKLGIKPKGDIIELLKTFYNVDALYNPTHTLCLTELIRRFNVADSNHFKMENSVDKIAGNIDFIVPNWRDFFSEFNIKKNTKEKDKKDSGSKKNIENKTNKEKSKNHSDRCDQNEDTNGVLEEEHHIDDDYASLNSDILNTTESSTNDKCENEKQVKKEKENLTETNKFDKVITCTGLSRLCKLILGKELEKIEQCSVWDRRPLRISQIRYAALDAEASRMIFLKLEEWGKDLNVDLKKIVFDCSNFTLKKSRFISVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA89</accession>
    <name>A0A0N5BA89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA89"/>
    <dbReference type="STRING" id="174720.A0A0N5BA89"/>
    <dbReference type="WBParaSite" id="SPAL_0000295900.1">
        <property type="protein sequence ID" value="SPAL_0000295900.1"/>
        <property type="gene ID" value="SPAL_0000295900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000027">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000295900.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37906" checksum="B76EC9BE183B98B4" modified="2015-12-09" version="1">MYTNPDDPKEKKSRGFCFIDFNEHKNASDCKRKMQMGRIKIFNTDLICEWAEQQSEVSEEVMKTVKMLYVRNLKEGASEQKVKDVFSAFGNVISVKRIRDFAFVDFEERDHCIKAMEEMNNKEFEGGILEISLAKPQLDPTKKKTNKQFNKVDKRKRLSYDHPDYEMYNYYQPNITYAHGPPRMPSYGGRPPYRGYPPIPPMHGYRPFHGFSPYDPYYDYQDPYEYYPPPHPVYEGYQEYNGIMPNYPTPPRKGNKKQRINLAGTKRRAEAMPEPATKRPGGHPNLPAENGAIYGVQPYRVQKNTYSTVPQTPKKDVDFSSDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAL1</accession>
    <name>A0A0N5BAL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAAA-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAL1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000307800.1">
        <property type="protein sequence ID" value="SPAL_0000307800.1"/>
        <property type="gene ID" value="SPAL_0000307800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF4">
        <property type="entry name" value="N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000307800.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43082" checksum="FA20ADD1E8F15875" modified="2015-12-09" version="1">MRYFHYLFIYYLIFNFSFIDALKVYNISLETKPRERWRIITNDYKDEIVYLMKNTSKLILPIIFPTSFFGLHYHFDDNVYFKLIELFILSKIPFHYREEMYGIASQLNRTAGEVLLLNIFYDLLASNDSNNLLPFESSSIIFQDNTTSLYHFTKFDYHFKNLIKNMTFIVNFNQNGNLLFTSHHYGGFIGVMSGVKAKKFTISLNSRAKGHQIDNMKYILHHQFNSISLTIRAILEYENSFEDAMLVVSETPYAAPASFTLTGTKCHQGIVVMSDRYKTLAIKYINESKYKFLLSNEEENSSKTSIILSEINYNMINSLENITSKDILDKIFESKLNLEKNSTNIFQTIMSSNISNLIYNYSKFIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCK8</accession>
    <name>A0A0N5BCK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis protein RPF2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000375450.1">
        <property type="protein sequence ID" value="SPAL_0000375450.1"/>
        <property type="gene ID" value="SPAL_0000375450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000375450.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14218" checksum="07FC28B0A64689B7" modified="2015-12-09" version="1">MAGILPEGGHHVMEKTECLRNSKSNLQLITLNAQSFKNNLLEFTKALLTFNSHSILMLTENRNEKESLFLDNHYLYLIGTVDKHYRDDGVMIPIIYKNNLTSFQHIGLSRIAENLKRKRKDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD56</accession>
    <name>A0A0N5BD56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD56"/>
    <dbReference type="WBParaSite" id="SPAL_0000394600.1">
        <property type="protein sequence ID" value="SPAL_0000394600.1"/>
        <property type="gene ID" value="SPAL_0000394600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000394600.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25935" checksum="C2E44591C3D3A2BA" modified="2015-12-09" version="1">MLSACSFATSLHCIERIFAYYKLISKCNDENESPHFTIFSYFATIFITAITQLLGNYFTILNSISSSLLFLSIQIITFVIFLYTVYKTNIYYRMKTSERSISLPLSYKYQLQQIYKSSKLLTLIIFCVVFSNVEGCCHTLIMYLISDEAINLIDHALTFQFVINLCIIFRLLILIFLQKKFRAFVNDKLSINLKSPKVEPLEDGPIFLSQTKDYFNFYAKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDD5</accession>
    <name>A0A0N5BDD5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BDD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000402100.1">
        <property type="protein sequence ID" value="SPAL_0000402100.1"/>
        <property type="gene ID" value="SPAL_0000402100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000402100.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47788" checksum="3B0AD2B705DEBF59" modified="2015-12-09" version="1">XIFLQLENKSVFSTMDLNKGYWQLKLSPEAQVITAFNFGVKHYQFAVLPFGLSVAPGIFQKIMQMVLKPVLEKYPTDVYIYIDDILVATSSTSLHLQILNEIFQLLQKYELKLNLKKSKFLQKEVSYLGMRLTSSGLAMSPEKLRKVMDFPIPQNKKTLLSFLGLANFLRRFLKNYTIDSKPLYDLSTQPTFTWTEQALESFQKVKKSLLEAPILTAPNFAKVLDESWPFFLTDASKIGIGAVLLQKVNGDMKIIAMFNRSLHGSEKNYPPTDLEALAISAALTHMNLILYGVPVTIITDHQCLTYIFSKPNLSTRLNKWKLHMQQYRIKTIKYMEGKSNFIADCLSRCLKVVETGNAEQFPAIQICSINRSFNWDFFPSRPEWQELQQRDEHIQLLYTFLDGTNKSNDITALPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDV6</accession>
    <name>A0A0N5BDV6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BDV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000418400.1">
        <property type="protein sequence ID" value="SPAL_0000418400.1"/>
        <property type="gene ID" value="SPAL_0000418400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="275"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000418400.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52734" checksum="D847380A056108B3" modified="2015-12-09" version="1">KKMEEHNLLYAFNPNLDLYITTDSSDLAAGAYASQYIEDEEVPICFFSKKLPETVKKRNSTFLEAKGIIMAIKEFEGMIIATKGKRIVRTDHKPLLSLVKTNNEPKYFDLVEIIEKHGIILEYHAGASNMLADDLSRNYEERSYVNFIADPDGALFPKLTRNDQEEDIETLNNLKLNVKIPEDKEQLILVQISNKKDGQENWVPYIPKEKVNIVLKFAHDFYGHQNRTKVTDLLLNRCYFIGMREEIKKYTENCNACLSKDSSFHRKPLIYQTVEFNAPMECLCIDAVGPLPLSNSKMKYIIGVLDSFSRYLILFPTDNLQHDNLLPLLYKYVFNRIGIPKILHSDNGKSFKNKKWDEALKKLNCTPSTGTPHHHNSNTLVERSFRTLQSILGKLLIQFKKDAKTQWTELLTTAEFMYNITPNQTTKASPYFIFFGREPRSQLEHFLNLSXXXTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEK0</accession>
    <name>A0A0N5BEK0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEK0"/>
    <dbReference type="STRING" id="174720.A0A0N5BEK0"/>
    <dbReference type="WBParaSite" id="SPAL_0000442600.1">
        <property type="protein sequence ID" value="SPAL_0000442600.1"/>
        <property type="gene ID" value="SPAL_0000442600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002164">
        <property type="term" value="P:larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000181">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="37"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000442600.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43344" checksum="83F2FDDA3FA4AD8C" modified="2015-12-09" version="1">MSSAPVTITSNGATLPGERQNGVEEIHGQIFAVAPRYINLSYIGEGAYGMVASALDTITKERVAIKKISPFEHQTFCQRTLREIKILSRFKHENIINIQEIISAPTVDQMRDIYIVQCLMETDLYKLLKTQRLSNDHTCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVSDPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKAIDVWSVGCILAEMLNNRPLFPGKHYLDQLNLILAVVGSPSQEDLTCILNEKARSYLLSLPHKPRQPWHRLYPDANPRALDLLDKMLTFNPNKRITVEEALAHPYLEQYYDPNDEPICENPFTIEMELDDLPKEVLKQKIFEEAENLHKNRESEKTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEN2</accession>
    <name>A0A0N5BEN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000445600.1">
        <property type="protein sequence ID" value="SPAL_0000445600.1"/>
        <property type="gene ID" value="SPAL_0000445600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000445600.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13545" checksum="18FCF16AD5650AAD" modified="2015-12-09" version="1">MKKIYSSLPVSADLDFNNDIVKHLFYYKKIHSTGFIKIAQIIILMCFISFVVINCEKSFQSSEEFNNVPIRDKRSLSIAQLGKLAERLKKLQEDLKKERVTDNYKDPKNPRGYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEW4</accession>
    <name>A0A0N5BEW4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">High molecular weight complex that consist of phb-1 and phb-2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEW4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEW4"/>
    <dbReference type="WBParaSite" id="SPAL_0000453300.1">
        <property type="protein sequence ID" value="SPAL_0000453300.1"/>
        <property type="gene ID" value="SPAL_0000453300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030421">
        <property type="term" value="P:defecation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00062420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000453300.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29773" checksum="7D5A984B49B5BF27" modified="2015-12-09" version="1">MAAQKLLSRLGQVGVGLALAGSVAKSALYNVDGGERAVIFDRFSGVHKTVAGEGTHFIIPWLQKPIIFDIRSTPRAVSTVTGSKDLQNVSITLRILHRPEPSKLPDIYLNIGTDYAERVLPSIVNEVLKSVVAQFDAHEMITQREVVSQRVTGELAKRASQFGILLDDISITHLSFGREFTEAVEMKQVAQQEAEKARYLVEKAEQMKIAAITTAEGDAQASKLLSKAFSDCGDGLIELRKIEAAEEIAEKMAKKQGVVYLPKNVQPLMAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG82</accession>
    <name>A0A0N5BG82_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG82"/>
    <dbReference type="STRING" id="174720.A0A0N5BG82"/>
    <dbReference type="WBParaSite" id="SPAL_0000499000.1">
        <property type="protein sequence ID" value="SPAL_0000499000.1"/>
        <property type="gene ID" value="SPAL_0000499000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000499000.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="56548" checksum="FDA880AD614A75CB" modified="2015-12-09" version="1">MNPDRQHQYKNQAKDSDSLRKNRVETSFSLRKEKREEALSKRRNIHEDTDPTTSSFAEDLSPNIPFDGKKLSEIVAEAKSEDPARRLSAVTQARKLLSSDKNPPIDDLISSGILPALVECLKTKIKELQFEAAWALTNIASGTSEQTRAVVQAGAVPKFLELLNSEHLNVCEQAVWALGNIIGDGPHFRDYCIKLGIIPQLLKFVTPEISINFLRNVTWVMVNLCRSKDPAPTLEVVTALLPALSVLIYHDDTAVLVDTVWALSYLTDSGNEQIQAVIQSSVVKRLVQLLGHQDGKVQTAALRAVGNIVTGTDEQTQHVIDAGALTMMPSLLMHNKTKINKEAVWFVSNITAGLESQVQAVIDAELIPLIIKLLDKGDHLTQKEAAWAISNVTISGNINQVRYLVDCGVIPPFCNLLGIRDTQIVQVVLDGLLNILKKSHPYVDQVTTIIEECGGLDKIEHLQNHENEEVYKLAFDIIDNFFSADDDNDNCNLDSGEGTSHQYQTENFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGG6</accession>
    <name>A0A0N5BGG6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BGG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000507200.1">
        <property type="protein sequence ID" value="SPAL_0000507200.1"/>
        <property type="gene ID" value="SPAL_0000507200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF12">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894559" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="62"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000507200.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="41137" checksum="2FDA2D2EDA749B0C" modified="2015-12-09" version="1">MLTSYNLIFICISLFYLIRFIETAPIDENDETLKSEEHDKFQKSYNNSVFKGVSQKLQKDIRIFCVILTSPKFKSSKCIPQKMTWLKRCNGYVFASSKDDPTLPSIKAFPKDNYKYSYGKVKNALRWVWKNHRNEYDYVLKADDDAYLVMENLRAFLMNENPDDHSYFGFTVYNPPGNKKNGYIQGGSGYVFSRKTFNTLVEKGLNNKKYCTQRDDVLDDMEIGRCLIRMGVNPTFLSDDRSRFVFNPERVSSILDKKKKTMNFYKRFSLFQPKRGMDSIADFPIAFHRINSDLMYFLEYLFYNAEVIGKKSRLFRMEDNDENNKNEKIEKRMELIRTFSKYNYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHU7</accession>
    <name>A0A0N5BHU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHU7"/>
    <dbReference type="STRING" id="174720.A0A0N5BHU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000553200.1">
        <property type="protein sequence ID" value="SPAL_0000553200.1"/>
        <property type="gene ID" value="SPAL_0000553200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000553200.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38973" checksum="3A97A75601E2CD3B" modified="2015-12-09" version="1">MSSRSECLLSIDETQKIHTNSFISKTKYTIKKVIKEGDFGSINLCVDKKGNEKIIKFLVKDSYKEEIQLNEYHIKTIKEFFSWNVNYQPFNRFNNILDHGQMNEMENSFIVYEKLGKNLNDVRKSYSKQQVEPIKGLQILLECISVINYLHNLGYVHRKIKPSSFCYRPSSNQQNPPIVLTNFEACCRIVDKNTSKNTSTVTKILNSKNFKYCSINQQTPNTFYTPNDDIESWYYVGILLFEGRLPWEDIKSGDDKKIKESKKSLQNIKTNHFYVKTPDVFRCFVIDIFKKEARIDVNELVNSMMKTITKYSRCNITDNSLLKSGNKEEGQKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHZ8</accession>
    <name>A0A0N5BHZ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SURF6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000558300.1">
        <property type="protein sequence ID" value="SPAL_0000558300.1"/>
        <property type="gene ID" value="SPAL_0000558300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000558300.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="20430" checksum="A69CB78B1BB881DA" modified="2015-12-09" version="1">XVFENKVKCGRNVQAHDVVYKRGDKDFENKEIFKIIRLYDKMRYEKKVKKMTKSELAEFRAKNFYSKKWRDRKTEKERVSKIRWNSKMRTERHRTMTEEDRSEYNRNVRKRKQKKKEVAEKLETLLKDSSEYKQLLKAEKVKKGKKQKIIDNGKEKLKKWLLPWPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIJ3</accession>
    <name>A0A0N5BIJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BIJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000577500.1">
        <property type="protein sequence ID" value="SPAL_0000577500.1"/>
        <property type="gene ID" value="SPAL_0000577500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="383"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000577500.1"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137188" checksum="D77F5F4F81D5311D" modified="2015-12-09" version="1">MNYKPNNNQSSGYNKNSIKTKHQKHGKVHTIEPTHDECHNDGEMNVIMHSIKEIKNMINDFKLNTLTICMLMICMLIPFGGCQPLGICRFAPSEFPRLYLQNNYDAKKAKQVTLVSVDTRCVALDVFASGYRLGNVFVDPDSNVEHYFDKKAPTFSCAGSHLVHLSGRNETFAEEVSTGTHNVDTSLKNIRAKHAMYEAGCDKLSSVSQTVPMDPHPSKIVSSTKAPVVMLTERPHIVQIVSHGTNVSASKIKAPTDVSVPSKATKSNNDAALKAASVDSLKVSSTTSGYQKIKSSLKTCEEELEKTKTLLKESTSTISDLRSEIERIKRANNMLSEQLRDSEDRHRTTLRSMTEESAKSLSEDIKTVSNALTDENRIRQECEDNWKDEIKRLNSEIEDCNTKLNKLKTANNALRGERDKASKALKSCNIDKDTCLKDLDELKSDVNRLNIALEDKDNELSEAKTLIDSHESQIQVYKNQEAALTEQLAAVNNRISQLENTELENDEEQEQNSSSNVHSLSECTNKEAQCHLQLIKTQSLNDLTRTELTRCESQIAVIKSRASSSPCLNNIPTTDNKSEKGLSMIEWAKKIYQLHVDEAITEMPNSIASALTLITAILVKYGFNKTAETLRKRYGSSSNNEIPYTHQLRTISEARPLTRTPIRVSRYGVIQNIRNSDSMVKLPVISINIGSNKFDALVDTGASLNVISQDAFNLIPSTHKTMVKPSLKAATVANNDKLVFSGASRIYVEANNKREQLEFHIVDKLSYDIIIGIPGLHRIFGDELTIRFNHSMPSITNVPVKTASKVRDPPRTTKVIHADVHAILSHEKINCLFVSNPRWKGSDHIMTYYQTGPVIDNKFAVILQNHGSNTVLIPANTEIGNLHSIEEVDDNTIRISGDEIIPEDAAWEDSLPNYPESHAPLTREQLMDSISWTNCTLSPKAKEVLQDIIWNNRTAFFEYDGNAGLYNGDERLNIELATSELPQRIRPGRRSREIEIEIDKQVEDMLEKGMIEHSRSPYLSRVVLVRKKDMKWRFVVDFRAINKLIKQQSHLIPRIDRLTEEASGHKYYSVFDLKQGFHQIPLDEHSRRIAAFVTHRGIYQYKVMPMGLTGSPDKFQDIMDKVLSNIPDCYIYLDDILTCSQDEESHIHNINNILSRIAEYNMKITLNKCQFGQKNAQYLGYIIDFDGIHPNPDKVKAITDKREPKTEKKELPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJF6</accession>
    <name>A0A0N5BJF6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein orai</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Store-operated calcium channel</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJF6"/>
    <dbReference type="STRING" id="174720.A0A0N5BJF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000608200.1">
        <property type="protein sequence ID" value="SPAL_0000608200.1"/>
        <property type="gene ID" value="SPAL_0000608200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.140:FF:000003">
        <property type="entry name" value="Protein orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000608200.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33327" checksum="B41E98D27A7A273C" modified="2015-12-09" version="1">MSLKDTNISPSSKKETIQIDSELFQQLLLEAINNSNTNNKIQHGINMDAKALYKQHYGELSIHEKYSYDLSRAQLKASSRTSALLAGFAMVALVELQYTEQTPRPLLIVLAVVTTLLVSVHLLALMMSTCLLPYIEANGCTKDSPHRRLHFYVELSWLFSTCIGLLLFLVEIGVIFFVKFDAVNYLPAAYITTAMLAPVLVLFLVFSYLIHKNRMRYSMERAHSKMDGIEKYVHDVESDPFERDILVDNSSSDFHKRDCGISTGSSVHDFPSPSLESENKSLRDFKNTRNIHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJT6</accession>
    <name>A0A0N5BJT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BJT6"/>
    <dbReference type="WBParaSite" id="SPAL_0000620500.1">
        <property type="protein sequence ID" value="SPAL_0000620500.1"/>
        <property type="gene ID" value="SPAL_0000620500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF82">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="160"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="296"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="366"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000620500.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50797" checksum="8CA381611A7DFE09" modified="2015-12-09" version="1">XAKKPRCKANEMLKPCTVCTDTCSFTRSLPPTPLKKCYNKKKECKKTSGYACVCKKGYFLNDKNKCVKKDKCYSKPKTTKKPTTTTGQCPPNEIWANCRSACEPNCFDNIKKPKPCPRICKPAGCQCIEGFVRDDSTNTCVKREQCSKTTTPFPTTTRKCPKNEIWNHCGSVCEPKCSDDPKKIKPCPFICQREGGCECKKNYVRDEVTGECVKRNKCTRTSTPLPTTTPKCSENEHFTKCGTTCPLTCSNYYNQPKVCTMQCVIGCVCNDGYIRDKQNNQCVSPIHCSRNTTYECPENEHFESCSTDCPITCSNHKNPPKVCNKMCRVGCVCNKDYVRNEETKQCVKREECSTGTTVEPETTPVCPTNMVYTNCKSACPPRCEIPRNVTSVCTFECAGEGCECREPFALDEFNNCVEREKCKKPSKGGYYIVHMLRKTVTTMYTLIFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLY4</accession>
    <name>A0A0N5BLY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-ATPase epsilon subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000693000.1">
        <property type="protein sequence ID" value="SPAL_0000693000.1"/>
        <property type="gene ID" value="SPAL_0000693000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000693000.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12219" checksum="CCDA8D737C260E62" modified="2015-12-09" version="1">MNAEIATVRHSFENIRTIKIFVPIEIFDRIMIAKVEGMRGVIMKHLSSKISDVVNSVPILSNSESESDDDRRRTIRFKDEEISLLTKWFREKNGEIPIKREFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BME7</accession>
    <name>A0A0N5BME7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BME7"/>
    <dbReference type="STRING" id="174720.A0A0N5BME7"/>
    <dbReference type="WBParaSite" id="SPAL_0000708800.1">
        <property type="protein sequence ID" value="SPAL_0000708800.1"/>
        <property type="gene ID" value="SPAL_0000708800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002020">
        <property type="entry name" value="PRK00823.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000708800.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18627" checksum="BB0294394248655E" modified="2015-12-09" version="1">MMPHLRCVLGGGRCQEMFSLFSPSIPCQRLLNNFTPIINTRVTERNLQIQSSFLYSSKIADKNKKTIMALSTDERNTLLMPLLENGWKMVNNRDAINKVINFKDFNEAFGFMTKIALMAEKMNHHPEWFNVYNKVDITLSTHDVSGLSKKDIKLATFIDSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNH9</accession>
    <name>A0A0N5BNH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminotran_1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNH9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000745800.1">
        <property type="protein sequence ID" value="SPAL_0000745800.1"/>
        <property type="gene ID" value="SPAL_0000745800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="69"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000745800.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55798" checksum="1128E30527C71507" modified="2015-12-09" version="1">MSIFISRSRVISKYFQPSIFFNCNTQNTLQNRFVSNSMIKMTKRVPSKNFGEYKQSIWVEFTTLAAQTKAVNLGQGFPDTPCPKFVADYLKEIGEHPERVDYMQYTRGFGDPRLTLALSKLYSRTLGVNVNQNNDVLVTVGAYLALYYSFTAWLNKGDEVLVIEPTYDSYVPQITAAGGTPVPVVLKLDKSNIKNGLSSADFKLDINALEEKITPKTKMLVLTNPNNPIGKLYSRKELEAIAKFVEKHDLIVVSDEVYEWHVPHATKKANGEGMIRFASLPNMYDRTITIGSAGKAFSITGWKIGWTIAPEHLSLPMRMLHQNCTFNVATPLQVAIARGFEKELTIFEKYDKSGDEKLLEDSYLLNILPNELESRRDKLANILMKANLTPIVPEAGYFMLADYSSVNLEENGKKIFDVIKEPKYGSINGEDEALDYKFVRWLCIEKNLATIPLSAFYSKEFKKDNEYTIRTCFFKSDSTLEKAEKILLALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP39</accession>
    <name>A0A0N5BP39_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP39"/>
    <dbReference type="WBParaSite" id="SPAL_0000766584.1">
        <property type="protein sequence ID" value="SPAL_0000766584.1"/>
        <property type="gene ID" value="SPAL_0000766584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000766584.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8319" checksum="F5CE5A0DC137268D" modified="2015-12-09" version="1">MSSAGSARLQFLMILNPSEQRIYTASKIHKVNRIHKETDKSNDARRQTQHATSENDDPFIRRVPIAVANTLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP73</accession>
    <name>A0A0N5BP73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP73"/>
    <dbReference type="STRING" id="174720.A0A0N5BP73"/>
    <dbReference type="WBParaSite" id="SPAL_0000770000.1">
        <property type="protein sequence ID" value="SPAL_0000770000.1"/>
        <property type="gene ID" value="SPAL_0000770000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000770000.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38881" checksum="87C21E5858593B91" modified="2015-12-09" version="1">MIFRIYSALVYAFHVFTVFIGIVIINHLGLFLFATNYGKLFRLCFFMNYATRFNTNLGDPEYGGVKYVTRNFYLHVQKGVRIGVWHTLPQSLSAILKIENKKFERSTFENAIKEHNHKVVIYCHGAFGYRGNGKSISVANKLSSNDCHVFILDYRGFADSSGECSEEGFYDDLKVLYKYVYSLAPGRIYFWGHSMGGAIATRVAADLCEIGKGPKGLMLESSFTSAFDAFIYYPLNTAYRSFSYIYKYAAERTEKCCVRMQNNVNILRVTCPITLVHAKDDWIVPFFMSQQLYIIAKDSGKDVKMIIFNEDEQFGHNDCIKSPDFQNILENFLELNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPB8</accession>
    <name>A0A0N5BPB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000774400.1">
        <property type="protein sequence ID" value="SPAL_0000774400.1"/>
        <property type="gene ID" value="SPAL_0000774400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000774400.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12292" checksum="FD440EC9304989AB" modified="2015-12-09" version="1">MVLPAMLYGWETWNLRKSDKKKLKVTQRVMERRILGVTRRDEIHNEDLRKQTNFNDIVHSAFTNKLRWAGHIARRIDNRWAQKTTFWRPYDMTRPLGRPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ07</accession>
    <name>A0A0N5BQ07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="SPAL_0000798200.1">
        <property type="protein sequence ID" value="SPAL_0000798200.1"/>
        <property type="gene ID" value="SPAL_0000798200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000798200.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="53205" checksum="D9C1460808A1E809" modified="2015-12-09" version="1">XSCSNDVDYKLTQSSKSLKEQVRTYVNPCEDFYHFACGSWLNKDDGEKKTEDGLEGFDMRGRYLNFTMDFLNGSYSRLSKTLRKLHSMSNDCDSIEDENLQIRCKGAIVQFSSYALVTYFFHTQILNQERYWKSLDKAQEMYENIHEEFVKIIENDDEILDDRSKKNVLRKLKYMKFDRHFPEHIYSIDRVEKCYDLFDYDLQDKPEDILEKIINYGNNTRAVIGDYPCIEFIKKKNYFHFYHRDAIDIDYLSNFNLITATPTILNDPHFSVDFIDALNYGSIGSLIGNKIGNAFDRLNIHFDADHNFTMLLTDESRKKYDDMFKCIETKYTNDKKDKIDEKVTLDDNYSDNIGLKIAHRAYMNYLQRNGDYELKVPDFEIFTREQLFFINYGRSFCESRNNVLTDGVSKGSKLKPGQVRITRTLANYEPFSEAFNCKVGSAMNPKDKCKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQJ4</accession>
    <name>A0A0N5BQJ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000815800.1">
        <property type="protein sequence ID" value="SPAL_0000815800.1"/>
        <property type="gene ID" value="SPAL_0000815800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000815800.1"/>
        </source>
    </evidence>
    <sequence length="856" mass="95850" checksum="209FDA4CCF8CA56F" modified="2015-12-09" version="1">XAALEHFRYIIGNQPVVIRTDHKPIVSALKNSNHKWLWKHISHIMQFNTPVEFIPGIRSQLADAISRAKIRSLEVIPSKDDDDFGQKLFSSIESDDDVPEETSPDEGSGLDSISDSDTDTTIDSNIMLNKVMVSKVKEIVMVREQVRLHRQIARQIVLEMEENNELPSLNQQPLNENEQLPPTTTTNNGINDGNGSGNSNDNPRNLSILNGSDQSHSAVNLNQQAVNLNQQGVNFSHQRPMSGHQNNVMHAGVNLNHQGPMSNLHNNGMFSAVNLNQHGVNLNHQGSVSGHHNGLLEVIQNPQAITELIQLLQRLVPPNPNVTNLSTSHRPLNSNVTNSTSSHGLNENGLNDTACQPTVTPQTRIPERQDCSYLPRKRNKPDLFTEEKVFTSWFIKFKIYVQHLPEEEKLENLIMLLDGKPLNDLELYPELLENYEDLVKHLQDNYNQKESRDSAARELQLHLRTKPKRINDLDEYASKLEKLVDIIERGSSKESIMRRKLDLLVDCIPNECKSKCVSVRHSTFREAVTYVKTIWNYDLTAALSTKSNNSILNRNQPPNSNRHDKTKRHESSNGKENSQVKCHGCGKIGHIRPRCPENLSNVKTGNNIIRTKPYCIENIPEKIEELKNQELIAIEVQINDINVVALCDTGTNVVTVHPDLANHLGLKKDKLIHIGTIAGGKAEKMSNQPLTNIPEKIEELKNQELIAIEVQINDINVIALCDTGTNVVTVHPDLANHLGLKKDKLIHIGTIAGGKAEKMSNQPLTVSYNFKSTVIKETMIAAQPCSFSLYQLINGNQVMKNLGLEINVKNLSVSETVQPMPTSMIIQKGKKSLLRMNLLKSLSTSFQMPMPSSVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQP7</accession>
    <name>A0A0N5BQP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQP7"/>
    <dbReference type="STRING" id="174720.A0A0N5BQP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000820900.1">
        <property type="protein sequence ID" value="SPAL_0000820900.1"/>
        <property type="gene ID" value="SPAL_0000820900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06346">
        <property type="entry name" value="Drf_FH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="391"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000820900.1"/>
        </source>
    </evidence>
    <sequence length="819" mass="90275" checksum="D6CBB74DB4129624" modified="2015-12-09" version="1">MAMIENISKGLLTPKEIKKCYAYLSKQSKDVMVQTDVISDEPYFNEANSVENSDSDKENSSTIHDQKHSNVLLKKKNKSLHDTKINLVQLDLHTYDVLEDKDIKKVNSQPTCHLCQKCLKSFCDIEVQTEKIDDKKMIPIPPPLPAGFSSNIKSNVTNYENVSETYNNLTRNSECDLKDNIPLSETNTISQSKIPLPPPLSGVKANSPKSPSLSGTKKIPPTAPPLPGTKLIPPPAPPLPGVKLIPLAPPLPGTKLIPPPAPPLPGVKSIPLAPPLPGTKSIPLPPPLPGAKSIPLAPPLPGAKSIPLAPPLPGAKSSPPLAPPLPGVKGGPPPPPPLPGAMGALPNMNDSKTIEMKGTSQTSASFSKTPPNSFLTSVSSLNAIHCSNSRSSVTYSKTKKTNTIQWTAVRNQVIINNKTIWNHFVEPDFPQDQREKLENMFERTKVVPKKVISKSIEAKKTSPNRNDTINKNSTGGLSEKRSLNLGIVLSRFKGIKGFDLVNALEKAHSSTFDIDTIQNLLVHYPTKEEREFFGKIESKEGLNNNEAFVWGVSRKPNLRLKLELMVFEANTTNDIQNFTKSGEQCLSACEKLMGNESVDQFFFKCLQFGNFLNQSTFAAGAQGFTLQSLLPTLQTKGTGTKSSLRMVDLLAEVADEVIFKVLDILPLLKEAKTFVLSEFEGAVKKLKHQILTIKKRVEMADGADELKNEYTELLNNYHSQCAKIENTMTEIKKYELDLQQFFCAESLKLEEILCIFLQAFTLFETAKKMFVSKTARIEKTGKLGNTKPLHVIRKTITKTDLKKNADIYNFIDMLNNSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR84</accession>
    <name>A0A0N5BR84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR84"/>
    <dbReference type="WBParaSite" id="SPAL_0000838725.1">
        <property type="protein sequence ID" value="SPAL_0000838725.1"/>
        <property type="gene ID" value="SPAL_0000838725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000838725.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11561" checksum="AFE46286BBC2B738" modified="2015-12-09" version="1">MNAARHAFQDADIKGCFFHLSQSLIRKINSVVLKSVIESDIQVKLMLKSLLSLAFVPLKDVRKNFDLLSATFLDVDAYNDILTYFFSTYIKGAARRNAQFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRF6</accession>
    <name>A0A0N5BRF6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000845500.1">
        <property type="protein sequence ID" value="SPAL_0000845500.1"/>
        <property type="gene ID" value="SPAL_0000845500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013311736" evidence="1">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000845500.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18719" checksum="2D4A9F49A669DB43" modified="2015-12-09" version="1">MKFIIFLTIPIIIFSLPKDHRFSNQSLEEIKYNIEQILSNSKYLIASQVDRKIENLINSAENVEKRDELIIWYKNLKDKRAHRKELLKTTIMNMSQEARSFILRIILIQQNTHLSPIEKQIRLRKISDLMSNEVRNEIAQNLLTHDHLQKFLPLNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRF9</accession>
    <name>A0A0N5BRF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRF9"/>
    <dbReference type="STRING" id="174720.A0A0N5BRF9"/>
    <dbReference type="WBParaSite" id="SPAL_0000845800.1">
        <property type="protein sequence ID" value="SPAL_0000845800.1"/>
        <property type="gene ID" value="SPAL_0000845800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF4">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894767" evidence="2">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin" evidence="3">
        <location>
            <begin position="375"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000845800.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="58885" checksum="7C792B3F5AB35D13" modified="2015-12-09" version="1">MVKFLVSSFIAVSSMFTTINGQLDAFALPSASRYAAKPTVPPELKGFFELDGHAKELIDTLMGPRPGGYFPEKTFEIASPRQSGIGGSAPRISNVERALENFFKGSPGEPTDIQLPPGFGQGFSLNNNGISTSFSNNKKPETVTIDEEIEGSGTEPKSSIKGIPKVFPKLPKAPISSPPAESKTIVMDKLPQIPRFASSRPEIPDGGLSPTSEIRRAPVNQEQLSSNVVKNSEYGKAGEGLSEEPKSSGGLIGTVLSLFGLNKEGKPADSDTVNKALTNLIGGNDSPLPAKDMISSVLYKALTNGSVQKNSTTESPKTEEKKKTTISGDVTKNASMPINLSSSQQAAINENLEMIQNLIIQPASPLCNPKPVPVDDFNIDAFMGQWYQVVYSPPLSSGPCSMLAYKKLADVNNGSVGSIFEIFEYTTDGSPYAKPKISSGYAIIKATGELIFRTSSNSDDVNIHVIHNGPINSNGEYEYSVLSANCNYPIYVFARDPVVYKQKYESIVNRILEKKGMMNGFSKLFNIVASVDSNMCTFPPSLFNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRV5</accession>
    <name>A0A0N5BRV5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRV5"/>
    <dbReference type="STRING" id="174720.A0A0N5BRV5"/>
    <dbReference type="WBParaSite" id="SPAL_0000860000.1">
        <property type="protein sequence ID" value="SPAL_0000860000.1"/>
        <property type="gene ID" value="SPAL_0000860000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000860000.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10192" checksum="ACA19727155D0EA0" modified="2015-12-09" version="1">MSATATTVVNPSQLLPLELVDKCIGNKLWIIMKGDKEFVGTLVGFDDYVNMVLEDVTEYENTPEGKRVTKLDQILLSGNHITMLVPGGEGPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS29</accession>
    <name>A0A0N5BS29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Velvet domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS29"/>
    <dbReference type="WBParaSite" id="SPAL_0000867500.1">
        <property type="protein sequence ID" value="SPAL_0000867500.1"/>
        <property type="gene ID" value="SPAL_0000867500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000867500.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43758" checksum="6BD64E3162304703" modified="2015-12-09" version="1">MNSFSMTNTNNIHPNYLEQVYNYHSNEMNPRLNSIQQQPPNYNIPNQPNASFSFSGYQVYDGVPMSNFSPPSSSNTSMNTSTSSDGMCNDYMKYLNSYYNYPNNFTPQTFNNSPLPSSNNHNMVIPSSMSTPPSLDNSSSSEYSSYIENNVYNQRNVRRIPRQCAESIPCTPVASGYKKKNQIQQEIESGVYEKCEKIPSYYEACQYVINHIDSNVIKFTMFMLMNPENASICHWTKYCWEFVVTDPDSFVACFCETFNLDKNLITISHVSKVYKCIGSSNVYGQPIIERVKCRRNAFRLFPKHQNFTYPRLKDLGSNSLSTTFLKNEEDKALGKLRKIKVNVPIFSRKRKGSGKNEEDSNEEVSRLTKKQKRIESNQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT47</accession>
    <name>A0A0N5BT47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT47"/>
    <dbReference type="STRING" id="174720.A0A0N5BT47"/>
    <dbReference type="WBParaSite" id="SPAL_0000903800.1">
        <property type="protein sequence ID" value="SPAL_0000903800.1"/>
        <property type="gene ID" value="SPAL_0000903800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058815">
        <property type="entry name" value="ConA_BAM2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26430">
        <property type="entry name" value="ConA_BAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="BAM-2-like concanavalin A-like" evidence="3">
        <location>
            <begin position="527"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000903800.1"/>
        </source>
    </evidence>
    <sequence length="949" mass="107956" checksum="81C232235DAA1C14" modified="2015-12-09" version="1">MYKFLSSTRFHVLSTQSKSLPEISFNNTDSSFNAPFIKLSPLVCQQIVIPRNECIFELNMDSDHVKVILTPLDQLVSLNFRTDKPNTRFFTVHYANDQTLNVDIVDGYLLTVNHLIHPLKFISSGKWHQLAVDLNNAVIYIDGINTAISIAPSNGQTHRKMISSIDFNLNGQLTNIRLNTERDILCDGDSKINIQMTQMFLRKICPHYSENYCHCQAPLSALTSSKKNKQYECESDKKKLNGFQLTRTPNQVSFLFLQNTFDNFKSLSVTFRTDSNIGLILFGVSKSPKSKESSIVQIHYVNEEMYALQCFKTDTLSRRCQSCQIRKKGGFALDEWTTVSLFHYNEYQFMTVNEQICQLIPNAYDFDSSLLYKISENVENVLFVGGMFYAKSSNLWKKMNLETITPFLDTTREKPPSLRGCITNLFVNGKKQKLDKIFNEQVAYFSRDNNEDVFGMTSHCSMCSEESQCLGGRCRPSTPILGSESVCDCASIFGIKKPNSQSCLLPDFVNNNITFKNDETVVENLILTHSTQNIIENIKFMGNRRAILDKVYLLIRFPSTSDSLVSILDFGSIRILVGNKGTRVIVEIDFTHREEFIISNSDNRLNLLNFERTPVIGTTSESRSIKVQLNDDIRYVPIEEIPLSNGAEITLSPVVSSNNVLHPGCIVTFSASYEYKETQHSHYPENRIDQKDILNLIISELKKQDPGLAKDLIKTSPCGIRDSSLWSFPGTSSIGLLNDYTSDPFFEPNIGRGSWIHFLFFLIIIVFLILLLICLCFNCVIRCRRTGSYKTKNKGDPSKTKGYSIIKRPLPKDGKIKRSCKSRLQTDSSERDYLQYEANMGSGANEYSPKTMSTHTPPSPDEWQRQPVRASRTYIERLSNMKYGQNKNPNNFDTPLTSHNKKFSSKYSNKSDSFLNDSIDFGDSPTYPYKAPIALQEDEFRNGPEKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTC8</accession>
    <name>A0A0N5BTC8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTC8"/>
    <dbReference type="STRING" id="174720.A0A0N5BTC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000911400.1">
        <property type="protein sequence ID" value="SPAL_0000911400.1"/>
        <property type="gene ID" value="SPAL_0000911400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000911400.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22518" checksum="66274D6889C6FCFC" modified="2015-12-09" version="1">MNRNEIESDLEDDYWNDALDETGNKIPSPELREDNEGDEGKKKSNVTSNNFRFVDPEDAKFEKLELDLGRFIEDVRQLGVTASDPGENANEIIRAKLRKIAAGLQNMNEVSSQFMNHQIPVKIFDFVDEMKNPNVYSKAVFEETDAKNSEVNGKIEQYKKYKSKILAKWAEEMPDAALQYMIMRKESESDKGPPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTF4</accession>
    <name>A0A0N5BTF4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SDA1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTF4"/>
    <dbReference type="STRING" id="174720.A0A0N5BTF4"/>
    <dbReference type="WBParaSite" id="SPAL_0000913600.1">
        <property type="protein sequence ID" value="SPAL_0000913600.1"/>
        <property type="gene ID" value="SPAL_0000913600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000913600.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26936" checksum="4A26ECFA6ADE87D2" modified="2015-12-09" version="1">MTLYICEMLHLMTIMADGNSIQGSDSVDRLLHLRVILEKIRPIENKMRSQIDLLIAPKADDNKEETLKARPNMLVLSDESEEDDDDEEEKETKKYKAPKIMPAKYTEEDEDKEERAMKKMKQRALQSSLLSELRAQYSNAPEEIVERFDNDRMLQKQKAIENYETSNFRRLSAKKAASLRQDKQSDALDKLLEFGDYMGVKEGPMTRKRKGSKKVNGVKSKKFKKSKKGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTZ1</accession>
    <name>A0A0N5BTZ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTZ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BTZ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000931600.1">
        <property type="protein sequence ID" value="SPAL_0000931600.1"/>
        <property type="gene ID" value="SPAL_0000931600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000931600.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49467" checksum="56B99E2D6E6D73B4" modified="2015-12-09" version="1">MNCELILKKDLTNDIIELDKKMSSLFETVFKKKDEPDENKKENFKSLVNDISRIEIDIIQRLKSVPCIDKTQKKIKRMKSEISKYDKAILKTEAGLYRIYGAVTNSLSIAQEKLSELKKSQQQQNTKNDILDISKSLTKNYSIAAPPFWKPEDYVKPFPTGVQFVRGCLKHNIPLKDISRRRILRTPTINTISNIRNLQQHDRMYSSLSNQQRQSYSMQQANYNLQNSNYKNMNKPYQSPKNQKGYMNQQRGSYQNFLQRSINPPHHYSQMANRVNKMPYQHDQNRYPGETQIGTKRFITKPGQSDIHQAAGISKRTPNAANIQMKPQRLPSYSSYLHKTEDGTTFKKAKKLKVGRNMRILPWSSFIDPYYKGYETSTSDDSDELNSEEEKEITTKYYTKKAGPSVELPVERTDSPDTSRHMNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU61</accession>
    <name>A0A0N5BU61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group-specific protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU61"/>
    <dbReference type="WBParaSite" id="SPAL_0000938300.1">
        <property type="protein sequence ID" value="SPAL_0000938300.1"/>
        <property type="gene ID" value="SPAL_0000938300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938300.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11492" checksum="4EAA8BEC3F633241" modified="2015-12-09" version="1">MTYEQYKISFESGYYLNVFGKANWNSTEIKNVIAELNCTRNVLVDEKHLENHMPFYLTTYLGGNSEPDCNVTIEYDKGNEKISDVFKIPEKCNMSLADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU90</accession>
    <name>A0A0N5BU90_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU90"/>
    <dbReference type="STRING" id="174720.A0A0N5BU90"/>
    <dbReference type="WBParaSite" id="SPAL_0000940900.1">
        <property type="protein sequence ID" value="SPAL_0000940900.1"/>
        <property type="gene ID" value="SPAL_0000940900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000940900.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17096" checksum="166D5C540610DDA4" modified="2015-12-09" version="1">MYHTSTHTTPYKIIHGYNPILKYDIQNCKDKIGYIAGKESLDDREASFMLAKKMSECINAKKDQLPNKSYISKMEKLKPGVPILVKLPIQLKRGEIGKFEFKWHDGFEIVKQIGNSYMVKRRGKGRPRKIHINHIKLDSSEEEDTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUA1</accession>
    <name>A0A0N5BUA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUA1"/>
    <dbReference type="STRING" id="174720.A0A0N5BUA1"/>
    <dbReference type="WBParaSite" id="SPAL_0000942000.1">
        <property type="protein sequence ID" value="SPAL_0000942000.1"/>
        <property type="gene ID" value="SPAL_0000942000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000942000.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25454" checksum="3BF2BD2128944037" modified="2015-12-09" version="1">MFLSHDCLDEIEDAICYEEAIELLQNNFSGQLNKLTAKKKLSSIRKHKSYRFEDFQEKVKNIDKCVKTLFSNRNYKKRLEETVFYSNKLLAGSVIQHLNSNEKYSSIEHYLQEPCGRCNFTSHKTEECRSKYKWDLISKQKITLTTIKSKNKTKTDLSDFTVEKATVYNHKIWVSLDTCANVDTISEKLAKKLGLKKNTQHDIQTIHGNNPIYSTQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVB8</accession>
    <name>A0A0N5BVB8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">(3R)-3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="19">1.1.1.239</ecNumber>
            <ecNumber evidence="4">1.1.1.n12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">17-beta-hydroxysteroid dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Estradiol 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Testosterone 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:24614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:32712"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14929"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.239"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14930"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.239" evidence="19"/>
    <dbReference type="EC" id="1.1.1.n12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BVB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000978200.1">
        <property type="protein sequence ID" value="SPAL_0000978200.1"/>
        <property type="gene ID" value="SPAL_0000978200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047035">
        <property type="term" value="F:testosterone dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000231">
        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="26">
        <location>
            <begin position="10"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000978200.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="26253" checksum="50DB910E839033C6" modified="2015-12-09" version="1">MSISSLLIGKTAVVTGGANGIGKAICSKLVEHGVKVCVVDLKKENAIETAKLLGKENYGFGCDVSKLKEVESLKEFVSKSMNVTPQIIVNCAGITQDSTILKMSEEQFDNVIAVNLKGVHLITQAFARLAVANNTPASIINVSSIVGKVGNFGQTNYAATKAGVIGHTKSAAKELAKKNIRVNAIMPGFIETDMTSAMPPKVLEQICKGIPMGKMGKPEDIADAVIYLGSDMSKYVTGSIIEVTGGIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWK9</accession>
    <name>A0A0N5BWK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWK9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWK9"/>
    <dbReference type="WBParaSite" id="SPAL_0001020400.1">
        <property type="protein sequence ID" value="SPAL_0001020400.1"/>
        <property type="gene ID" value="SPAL_0001020400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001020400.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14328" checksum="8F9B933CBBCD71C9" modified="2015-12-09" version="1">MNVSAFFHTPGQPLECLSIAVELRKEIVSTSDNEVTYKVGLKIGGGIDQDPSLSPFKYPDNGIYITSIDSNVAQKSGLRQHDKILQVNGHDFTMITHEKAVKYIKKYPVLNILVARNQINNIESQERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX06</accession>
    <name>A0A0N5BX06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX06"/>
    <dbReference type="WBParaSite" id="SPAL_0001034400.1">
        <property type="protein sequence ID" value="SPAL_0001034400.1"/>
        <property type="gene ID" value="SPAL_0001034400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894968" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001034400.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="15210" checksum="6E1DF1DF27E658D9" modified="2015-12-09" version="1">MLILRLIILFLLFHSINGNKNKEAIQLLTKKISGFEKEEEINMKMKEIKKSKDLKNDLKYCVWLMILCNDYTIDTFVRSEHCHKYYSFESEKLSLPPKHNEVTEQHTCWKYIKNYNVNMDDLYVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX82</accession>
    <name>A0A0N5BX82_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX82"/>
    <dbReference type="STRING" id="174720.A0A0N5BX82"/>
    <dbReference type="WBParaSite" id="SPAL_0001041600.1">
        <property type="protein sequence ID" value="SPAL_0001041600.1"/>
        <property type="gene ID" value="SPAL_0001041600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001041600.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49522" checksum="5715FFABD67988A1" modified="2015-12-09" version="1">MREIVHVQTGQCGNQIGAKFWEVISEEHGIQTDGSFAGDNQAQCLDRIDVYYNEANGGKYVPRAIMVDLEPGTMDSIRASTYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVENVMDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSSFSVFPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLASPTYGDLNHLVSMTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLAARGVSAYNALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGQMSMREVDEQMLSIQQKNSPYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNTTAIQEIFKRISEQFTAMFRRKAFMHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQEAGIEDGAGEEYEADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX95</accession>
    <name>A0A0N5BX95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX95"/>
    <dbReference type="STRING" id="174720.A0A0N5BX95"/>
    <dbReference type="WBParaSite" id="SPAL_0001042800.1">
        <property type="protein sequence ID" value="SPAL_0001042800.1"/>
        <property type="gene ID" value="SPAL_0001042800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF10">
        <property type="entry name" value="LD45603P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001042800.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="70022" checksum="823EB92C07F5AA97" modified="2015-12-09" version="1">MNLICCSSSENLNEKCKFKDFCENQRNLTCGCFITIEENFLCSLDSSIPTTQQWYDHESNDFGIINCKSLNLPNSFNVEHFVTIKTWNSMLTPTLLEGLSHYNVTSLVIKIKEGNEEMQYEDLNKYFKNLNQLTIQFTSPTSTEIDLNSFFINLSNLTSLKLINVPFQFTTRTSSWIKSIERLHIENNKNLIYLPKWFSYGHSLKKLTIKKTSLSDITSISLLPKLEHLKLSFNEISNIHRISFISPFLEVVDLSHNKITRLAPHTFSQAIQLRYLDMSNNNFHSPLPESVFSRNTKLKYLSLAKSYITHLTAEAMTGLGNLKTLILSYNPTIRLDIFTLLPLKSLQKLELNWCNLTKMPIAVTQCCHLNTLQLNGNLFYKKDSMPSEVLAMLSSITSLTFDRNPLIEMPYGLFLVPVNNIELIEHILETLIQLPLWQKEPCTPYMWNIHLTNSSNELRKKVRMWDEERMEANLLQHCKQLYESTLEKLELYRELEQNSGCEASRKLRSARDSCAIKQIEMERMIEEKIKNEWNDKEVTEIVPPNIKKHKIENFLIVSLATNMFLGSFFGTIIIFLILKRIKKCWIRKNHEELAGNTYSENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXJ1</accession>
    <name>A0A0N5BXJ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BXJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001051700.1">
        <property type="protein sequence ID" value="SPAL_0001051700.1"/>
        <property type="gene ID" value="SPAL_0001051700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="326"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001051700.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="72416" checksum="45F62D5473B09D40" modified="2015-12-09" version="1">MERKEEIVSDVKIILVTGGVISGVGKGIISSSLGVLLKANGYRVSAIKIDPYINIDAGTFSPLEHGEVYVLDDGGEVDLDLGNYERFLNVRLRRDNNITTGKIYRHVIDKERHGDYLGKTVQTIPHITEAISDWVERVAQIPVDGSHDKPHVCIVELGGTIGDIEGMPFVAAFEKYQRPRLRKRFMTVHVSLVIAPKSTGEPKTKPMQNSIKNLRTAGLTPDLIICRSEKKLTEKLKNKICEFGLVDSEQVIGVHDCKNIYQVPILLQSQGVIELIKQRLHLEPSNKEAMLAAVPNMFQWFEFSNIVDSFTEIVNIALIGKYVQIEDAYTSVNKALEHAATHAKRNVKIHFIQSQDLEPETNEKTREEAWKKIKECQGIIVPGGFGKRGIEGKILACQYARENKVPFLGVCLGMQCAAVEFARNVLGIKDANSSEFDKDIPFENQVIIDMPEHVGENVDMGGTMRLGLRTTVFLTEDCKLKKLYKSLIIEERHRHRYEVNPLLVPKLSEAGLLFVGMGVDESSNIDDIQRRTVSANNLIQMATSPQSGNLLQTINELCTRGGNGISKTAVRMEIIEMKDHPYFVGCQYHPEYLSHPITPSPPFLGLLLAASGQIEGYLSGEKIPTPIKNLSHRGSKENSFSENSDAQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXV5</accession>
    <name>A0A0N5BXV5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXV5"/>
    <dbReference type="STRING" id="174720.A0A0N5BXV5"/>
    <dbReference type="WBParaSite" id="SPAL_0001062000.1">
        <property type="protein sequence ID" value="SPAL_0001062000.1"/>
        <property type="gene ID" value="SPAL_0001062000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001062000.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11935" checksum="18E791BEE4FE17EF" modified="2015-12-09" version="1">MPSFGNNSKISGLQEYSVAFEERNRNSPKTCAVCSGSTKCFHYDVPSCNGCKTFFRRCILSGKQYKCRFEENCLITEGSRCKACRFNKCIQVGMNPNGMTKYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYG7</accession>
    <name>A0A0N5BYG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Syndecan domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYG7"/>
    <dbReference type="WBParaSite" id="SPAL_0001082200.1">
        <property type="protein sequence ID" value="SPAL_0001082200.1"/>
        <property type="gene ID" value="SPAL_0001082200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001082200.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="17682" checksum="0447FC072AACA1B3" modified="2015-12-09" version="1">MLDGVGRFFKGALNRVTFGLVSSPEEDDAKAAAAAQAEHNRKMEDLLARQNNGPKEINNNNKNSQTSSQNMSSENKLNNENKNDNINKADSINNNQVSTVQAKSDQSTNGIIGLGAIGLIAVIAIVVVVVVMKGSGSSGSGGGGGGRNKGSVSSSSTSSTASSTKTKTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYH6</accession>
    <name>A0A0N5BYH6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYH6"/>
    <dbReference type="WBParaSite" id="SPAL_0001083100.1">
        <property type="protein sequence ID" value="SPAL_0001083100.1"/>
        <property type="gene ID" value="SPAL_0001083100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="171"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001083100.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="44069" checksum="10A501788C121B55" modified="2015-12-09" version="1">MENVKIYLRMKLGNVKGNEIGKCQGKILDFGFYALRSLFLRKSINKNEKTMDFEGVKELIFERLKEEFKLLIDEKKVLFTNETTEHFLDKLNSMKFGKNYHDYDISNLELMEKCYKNFAFLTSHSNIHETLTNLEFQKNKSSKNHKLDEFSSCEDKFFYSDEMLSKYVFSNGWYNGETNTIYINSDALNEPSFSRDFPRSLNFGGLGHSIALLMLTPFGSHNYNRTFYIDNKNASKVAEESIKKITNKINCFVNEYGMQKGSITNRYINGSLTLAGNIAENGGLKIAHRTYMKWLQRNNYGDIEVPAFKDFTKEQLFFIGIGRNYCEYKSKDYIENQMKIDDHPPAEIRTNVALSNYKPFSDAFNCPLKSKMNPEGKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ91</accession>
    <name>A0A0N5BZ91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ91"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ91"/>
    <dbReference type="WBParaSite" id="SPAL_0001108400.1">
        <property type="protein sequence ID" value="SPAL_0001108400.1"/>
        <property type="gene ID" value="SPAL_0001108400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="539"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001108400.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="70542" checksum="2B0BBE33A36762ED" modified="2016-05-11" version="2">MAVLVEILHGEPDVIMGKNKKRKGENPDDDFSLSVSSMKHELKALREEIHNIRELKSSTPIRGGPKPTLFQSTDVNGAPEALISTLQLSIIVQRLQTLPQIDGSENLENIADTLIKAQQIVKDSIASIRLGGDSLIILKGKALRTFNRILKESPPSLMEAIESLKNSIWRTERRNFIAIKAVINQKVRQEKMTIQQFAIDIEDNVESGFQPLSEDAKSLMKSLLFKNGLRNPQTMNAIAHLKNTDFDELVEAANNFESSKRKASSPRPPTPIKPDNWKADDPCYIHKNSKHSNLQWMVQKATRAENHQKETRVCTKENDTKTGELKYIETLLNGTKFIAQMDNGSNNNICDFETFEELRKQHIVNDSDLRLERERIRGIASYAETIGKFQCRLEFMGTNVEAEFNIIKNFPNPLIGTLTLDALGIKNVKDGKEIKFLSAYKPTSKTTHYAVSNTQIEQLNKEYDEIFINSVEELKYDPNNPKKSMKIEVNSSEVFKGTPRHYPPKVRNLLIKLISTFRQNGIIRLSTSPYSSPPVVIVKKHDEDGNPSEIRLTIDYTKLNNITIKQNMPTENIETIIDDIGNKTILSKIDLSGGYHQFNLEEESKKYTAFAINGNLYEFNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZK0</accession>
    <name>A0A0N5BZK0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AMOP domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BZK0"/>
    <dbReference type="WBParaSite" id="SPAL_0001119100.1">
        <property type="protein sequence ID" value="SPAL_0001119100.1"/>
        <property type="gene ID" value="SPAL_0001119100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895092" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="12">
        <location>
            <begin position="203"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="597"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="13">
        <location>
            <begin position="767"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1347"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1363"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001119100.1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="158152" checksum="05CC7873320B6DF9" modified="2015-12-09" version="1">MSLYIYLCIFLYLFLQNSSLIFSQQTYQEYSTVDLFGNKNPIYNYLPNPGHVDVKKLDEYLEQTDHRMEEGWWHLFPYGPLYHDASILTKTNHDRQIDFDFDFPFYGFRFNYTMIYPGGLLAFSDPEFIQPPYTFPNPRWPEQKDASFIAPFYADQQFQYIGEKGISNVWYRLVFRPRAYENFDEWGDPLMRNGNDKYSDMFRTPYDRYHKQKWGRVEDPYLLDNITMAIREGIIGAHGFRADYAVIVTWERMAYGGAPKITQVNKFEEAKRWTNTYQVVLATDEIRSYCIFNYAHINWTSSNTAGALQGRGGLQSAIAGFNAGNGTGWTPLPYSGEGRVLKLQEFSNVGVPGRWLYRVDEQIIPGGCSNESVGFMTTAPIAASMIGGVLVNVSGPCLRSGDVVKVIFDEYQVDCERLSMIRAQCILPVNKMFRTGLVQTRMSRDGGQSYPYVGTFYLLQPALAMPQVKLIDNPRESFNNWRSSNATKLRLEWAPYNLTNDINAQIDITLMGYWEDTDDHIFEEVGTLGLRLPNSGSFEFDPRTMARTHMVLDSWRRFSFGFVRVALSDQHESNGAFWSKMTPFGWYFRDVWEYEYGSDWALELCKDWFDYDGRRINYAMDLEPSVPCPCVLDQALLDIGRFMPLIGCDRDGDASCNYNKGAQHCVMSTGSTWTGAGQVCCYDFEGWLMHSDDYENAAHLRFFSPGTSQRSHPLGSYPFKRPPYVPSLSNYHTDVMAYEKCCKWAGNCEFYFWRRQTSGCQEYIPPVAGIAYGDPHFVTYDGTRYSFNGKGYFMLTMAKDSIHDFQVQVRMEQPPKTDWNQEVMGTVITGMAARENDSDIVQIFARKDHRRWRYRMDVVVNGYYCYFDTPELKLQKFKGVTLRSPERNHNQSEIHVMFESGVGIQVQEAHGVLSVMVLLPPQFNETYAFPRGHDYYGTGHDEYGRSTSNVRADFSDLLVPPSTLQYSAGIQRFVTVGLLGTFNDNHLDDLMSPDGQITIVNYPPTEQDNRNAYEFGRRWRIDGSKYKLLFQDHIKPIYDPLKFGNDYSYEPVFDPYRLQYNASLVFTLEEVRVACQNVYECEYDYFLTGRREIAMATLEVQKKLLELKEKGSKRKQSCGALLTGPGVIKYPPGNNYLDGVTVTFTCKPEYFIHGTPQRVCVNGTWSPGWWTWCRRRTLETGLKWITGVLSSTAILLFIASIFFACYLRRISLHPETKITLRRAESCGGLSRFAKSGRKDGGEDKFEDGNYISGRMSGEMYDSRLPGTIKSPIQSRRSVRIAQVPDIQVIPPSTESSQESRETYINQMIPSQRLVAFSGEAEIPQQPIRHYKMEERYEYEYYNGAFDDTENIQGPPLTLRHPHQSQFLGRETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C010</accession>
    <name>A0A0N5C010_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C010"/>
    <dbReference type="STRING" id="174720.A0A0N5C010"/>
    <dbReference type="WBParaSite" id="SPAL_0001134700.1">
        <property type="protein sequence ID" value="SPAL_0001134700.1"/>
        <property type="gene ID" value="SPAL_0001134700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001134700.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38481" checksum="E849E60EA1E1B04E" modified="2015-12-09" version="1">MCSIEKFPLRTEKTGERVTSRTFIIGCKNRSEWYLEIYPNGHNSDSKDYVSVFLMLKKPDKASAKFRFSILNDKKGEKNSITFSNVRDFVKNMRLGSPRFVRKDFLLNDSNGLLINDKLTILCEIEIIDVKSEYHNNPKTSINATIPQSKSLLNYGKMLNSSLYSDCIIKVKDTEIKVHKVVLAAQSPIFSNILKSKLEESGTNVIEIENFRVEVVREMVKYIYTDEVSDIQNMANEVLEIADKYGLDRLKAISAQYLCRNLTIKNVCERFALSEKCSIQSLKECCMEFIIENDECLMETKEWKEFVLIHPLLLESLFLKALNISLTESISEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C077</accession>
    <name>A0A0N5C077_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C077"/>
    <dbReference type="WBParaSite" id="SPAL_0001140900.1">
        <property type="protein sequence ID" value="SPAL_0001140900.1"/>
        <property type="gene ID" value="SPAL_0001140900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001140900.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24084" checksum="F34F3899DBB94A12" modified="2015-12-09" version="1">MPSREEKLKCVLSAANALGLNISEEVVPGKQLSVINLLLWGYSDTPEDLAKNIESIVFDIKQVESSFVNFYEQFKDAMEFAADDENGEGTNPVPEKKQIMLLKGKLSEKVMERLRTLDQGSDLTQITEYLKECYAKHEVSKEKLRIKINRMKREDFKNYDDYIKELLKLCEQYHMKEEKDTRNKLIIADIVCKHDVQTQRAVENCGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0C4</accession>
    <name>A0A0N5C0C4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0C4"/>
    <dbReference type="WBParaSite" id="SPAL_0001145300.1">
        <property type="protein sequence ID" value="SPAL_0001145300.1"/>
        <property type="gene ID" value="SPAL_0001145300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748:SF1">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001145300.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="33002" checksum="FC66CC6C7751F6DD" modified="2015-12-09" version="1">MFDIVSCVEIIQLIYKIPSMLLMMLTIYVIIKEIKNKNVYFNKQFYTIIVCKLINEIIFIINIYVFTIIPKWGFYNHFLENNNWTAGIFLSLASQQTTFMFFITLLISINRYVAVKYPLSYKIYFSKSKIVVILLSSIMLSTMFGLVNISFKPRYIKYPLYGYIVPYLQSKDVIYYQVFCQIFLFGIISITTCTLNVIAILTLKKHNLIGNKYKKELHYTTYSIFVFITLFLIEAFFVCRFITVNYAIKFFSYIANFLHVVAFDLTYIGNFYFLLYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C116</accession>
    <name>A0A0N5C116_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C116"/>
    <dbReference type="STRING" id="174720.A0A0N5C116"/>
    <dbReference type="WBParaSite" id="SPAL_0001169500.1">
        <property type="protein sequence ID" value="SPAL_0001169500.1"/>
        <property type="gene ID" value="SPAL_0001169500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="9">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001169500.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37106" checksum="D3FC6F6081CA9492" modified="2015-12-09" version="1">MDEQFKVFLELKTRLKTAQILAPPDIARNFIIHTDGSEYAIGAVLLQKNKEDQYPRIIACASRTLHDVEKRWQVVEKEALTLVYAVKQFKYYIEGKVTDVFTDQRAVLAIKSPKENQSKLRRYQLALAAYNLNIYYKEGKANVIADLFSRNPEPKEPLVLMAHTIKQVTKDDDFKEMRTSLFMEGWHTSRKDEEFLQNEMKNKFRRLGNLVIVKIRGEEKFFVPDGERVKLVKHIHEHPKIGRHFGAHRIKEVITKCFWWENMEVKIHCEKCQKVKFHPETTTEWRGTWDIPDSPWQQLNMDIRGPLPITARRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C278</accession>
    <name>A0A0N5C278_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C278"/>
    <dbReference type="WBParaSite" id="SPAL_0001209100.1">
        <property type="protein sequence ID" value="SPAL_0001209100.1"/>
        <property type="gene ID" value="SPAL_0001209100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895226" evidence="2">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001209100.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11849" checksum="A405188F7B5D70C4" modified="2015-12-09" version="1">MKSITFGIVLILFTNLLTTESFAIKGDITINNKENADSLPIILNDEDVNDIQKRQNRARRLRRQRRRRNQQVRSIVTNVANLQTQLNNLQSALNSRLASVATMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2H9</accession>
    <name>A0A0N5C2H9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF hand</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2H9"/>
    <dbReference type="STRING" id="174720.A0A0N5C2H9"/>
    <dbReference type="WBParaSite" id="SPAL_0001218800.1">
        <property type="protein sequence ID" value="SPAL_0001218800.1"/>
        <property type="gene ID" value="SPAL_0001218800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001218800.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22520" checksum="728A0B0D3CC0DDBC" modified="2015-12-09" version="1">MMEEVVRNDECINKMSDLNSVESLFSHQLNYKMSKATKKKSSKKRAGSEATAFDQKTIQEFKEAFGIMDQNKDGVICKNDLKDLYASMGQIASEKQIDDMIKEAPGPINFTVFLTLFGERLTGTDPEQTIVGAFAMFDKKESGKITEDELVKILKNKRGEPLDEDEIKAMYKGNPPIDGGMVDYKAFAHLITTGAQDELANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2T7</accession>
    <name>A0A0N5C2T7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RVP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2T7"/>
    <dbReference type="STRING" id="174720.A0A0N5C2T7"/>
    <dbReference type="WBParaSite" id="SPAL_0001229400.1">
        <property type="protein sequence ID" value="SPAL_0001229400.1"/>
        <property type="gene ID" value="SPAL_0001229400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retropepsins" evidence="3">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229400.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24134" checksum="CB329D4AF9A21DD8" modified="2015-12-09" version="1">MRQEEQDEERGLLMDPREQRNTKRGSIVSLNKDDEDIERILGERRYQYILAVIGDSKESNPIVTLRIHGKLMKAYIDDGSEISLLSKKRWQDIGKPYMKESDVKARNTNTEVPIIGQSKINLEIPGKSSKEEVFYIVEDLTSEVITGRSYLKQYQTFKHDYKNNCIFLGPNKLPIWFESKRSKLVLKANKDETIAPGSYQDFPSEGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C330</accession>
    <name>A0A0N5C330_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C330"/>
    <dbReference type="STRING" id="174720.A0A0N5C330"/>
    <dbReference type="WBParaSite" id="SPAL_0001238500.1">
        <property type="protein sequence ID" value="SPAL_0001238500.1"/>
        <property type="gene ID" value="SPAL_0001238500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001238500.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8999" checksum="585C964E448DEE65" modified="2015-12-09" version="1">MSVTPINPKPFLNNLIGKNIVCRLKWGMEYRGILVSVDSYMNLQIANCEEYIDGSNAGKLGEVLIRCNNVLWVSEGVGEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C377</accession>
    <name>A0A0N5C377_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C377"/>
    <dbReference type="WBParaSite" id="SPAL_0001243200.1">
        <property type="protein sequence ID" value="SPAL_0001243200.1"/>
        <property type="gene ID" value="SPAL_0001243200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895492" evidence="1">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001243200.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18803" checksum="0C9A83E21D97EC9E" modified="2015-12-09" version="1">MKYFFTIFILAISLKNIAIKSQEHGDNNNIDQVKFNLDNHSLRNQQQHNTDSSTFHYKEPKKVRCYECHSIGNASWLSSCTRKRFCTGLWCVKGPDDGGFFRGCMDTLPFLDHTEKCITYKDTNGIIKENCYCNSEFCNSSTSLTLPLLLIISSFLLILRFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3B7</accession>
    <name>A0A0N5C3B7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin GTPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3B7"/>
    <dbReference type="STRING" id="174720.A0A0N5C3B7"/>
    <dbReference type="WBParaSite" id="SPAL_0001247100.1">
        <property type="protein sequence ID" value="SPAL_0001247100.1"/>
        <property type="gene ID" value="SPAL_0001247100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="term" value="P:intracellular distribution of mitochondria"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <source>
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    <sequence length="736" mass="82876" checksum="82F5C17311F2C750" modified="2015-12-09" version="1">MEELLPVINKLQSIVALTGAHHDIFQLPQIVVVGSQSSGKSSVLESIVGRDFLPRGSGIVTRRPLLLHLIHVSEEEVSRRRGNSSSTDDCDEEWAIFDHDDEKVYTDFNLVREEIIRETEKESGTNKGISDKPIGLKIYSPKVINLSLIDLPGLTKVAVGDQPENIEQQISDLILKYISNPNALILAVSPANQDFANSDAIKYARTVDKEGIRTIAVLTKLDLMDNGTDASEVLMGKIVPIKLGIVGVVNRSQRDINNNKSIKESLKDEVEFLQKKYPTIVQKNGTVYLSKLLNKLLLGHIKKSLPQLKEKITMLTQQFQAEVFMMGEPTIDKSGTLLNILTKFNSSYCAVIDGTFKNIETNELCGGARISYVFHEIFAKAIKSIEPSKGYSEEAILTAIRNARGIKTSLYVPEECFELLVKQQIKLLEEPSLNCVDLVHEELIRLIQNCGTEFQQEIYRFPVLGNNINNILRDLLKSRLEPTKKFIENLIAIEIAYINTRNPEFEKIIKDGNIIYTMKENLKSRSRKNTVTGNTYGGSNLQDISHQQPSSSISKHGNLKSIFKKKDDPRALEGITSWFFGNNRNALEEPNLTGQNFSSPCIDEVTSVNSETCDMATAPCFTPKQVMSNEKIEGGLTDPEKSDCQCILKLTREYFNITRNRILDTVPKAIMHFLVNEVRANLHNELVRNLYDKSKIDELLVENDEIERRRQHSISTLDILKKAAKILSEIKETVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3J8</accession>
    <name>A0A0N5C3J8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3J8"/>
    <dbReference type="STRING" id="174720.A0A0N5C3J8"/>
    <dbReference type="WBParaSite" id="SPAL_0001254300.1">
        <property type="protein sequence ID" value="SPAL_0001254300.1"/>
        <property type="gene ID" value="SPAL_0001254300"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895395" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001254300.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18588" checksum="B2065165A5982F8B" modified="2015-12-09" version="1">MKWSCITLLFLLSLSTLSEGRYRNALSKVVSENADNECGDFYGMFFMDKSLGGSSIIQKQKEIIKDFFNSNFKPTLNSLVAASSQVDDEITNPLNTVKPFDYSSLEKQFSDISSALSTNETVSFYKLVLDVWLNADLSNSDLYTKNPIIVLFINSYVEDKNPTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4Q7</accession>
    <name>A0A0N5C4Q7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4Q7"/>
    <dbReference type="STRING" id="174720.A0A0N5C4Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0001293800.1">
        <property type="protein sequence ID" value="SPAL_0001293800.1"/>
        <property type="gene ID" value="SPAL_0001293800"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ_SHANK1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="352"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1056"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="882"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001293800.1"/>
        </source>
    </evidence>
    <sequence length="1121" mass="125078" checksum="501774A9C0795CA5" modified="2015-12-09" version="1">MLRLDEKSLKQLHSKSNLKKFMDYVQSRNSAKVEKFCHQGLDPNFHDVNGETPLTLAAGIQDNRDVIIQLVGGGAHLDFRNSEGQTGLHKAAFLSLVGNVKTMLELGASPSYKDPIGLTPLYYSMLTTESDDRITEMLLAEASEIGVTDMHGNHEIHQACKNGLTKHVEHLLYYGANANAQNINGNTPLHVCSVNNKPECARVLLFRGANVNIQNNQGQTALHVAQLIGNQQVVEVILHYNPASVVPYRSTPKYNTKRRIPSSTISRRRSLSQVSISSSMQSENFYRAPSQMSNSISASRLSSINMKNNMDDQLSNDSSSITMIPSSSPSLHSGNQTIYSNNRTDYGTLKRILVIPRGPKGFGFILRGVKNLEENEVFEPTPLVPGLQFFEGVDMAGMAMKAGLIPGDFLLEINGIDVRRASHEQVVQMIQMVQETITLKVITVDSSAQSNHFATLNPNTLRRSVHYGVVSRQPPPPPLRHPSTSLSVARGISMQQHILPCSSMKLPNYNHMTQRRISAAELENLMARRNMPVQMCTPNINNYDMSDLISNSSEYASSNGKKFNSVADMKRKKQVRASMNTSIYEASIESQKNHYGAPQHYQQSYYGYESRYIHGNESNDSRIYYGDNQHMNIKQSKSSPEVNQQYTYDGDNYNQLKNKRVHGVGRKSSISSNSEYSKTYKTSLRPKTPPPPPPISNLMDEEDDDEPPKIPQVDYNDFDSDETDNEPKIIYQSAQSTVIKTHQPNNNKYPEENKKASTTKSGSGVPPPPPPPLPIDLLNKTPTNKKNDNKSCNNTTKSIGISTALLTTVKLNSVPTNSNNIDSKVPQVKKIGKRLDFDSDLRNALARRRQKVCVEDEDGDDNGKSNESLNNIGALSLKESVRENVENQQSKLSVNVMGKNSNNCLTQKKDSGYTSSRTSLEPSENGDDGHHGENHEKNDNIINKNNIKSNTVSLISQQIEESCNEISPLNIGKNYNPTIKINFASETKNGNNMSYVSTTYVYEQKAESPTSGRSIEGPIKTPPVDYDEPDSGHGDSDQDDKPHILNGYKNKDLINWTVMDVIDWLTSIRMSEYSKNFQKRNIRGADLMIFDRTKFTQLGVTRIAHRQCMEQSLRSFNSNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5B0</accession>
    <name>A0A0N5C5B0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5B0"/>
    <dbReference type="WBParaSite" id="SPAL_0001313900.1">
        <property type="protein sequence ID" value="SPAL_0001313900.1"/>
        <property type="gene ID" value="SPAL_0001313900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001313900.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9686" checksum="15AD5D0CE4F59E95" modified="2015-12-09" version="1">MFFQKHREIRIMKIGRLGKVVEEAKRKEIKQRSSQQRISTEVPLLKQLEKENLAPENIVKCIYKEISTDFDETFNDEIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Q0</accession>
    <name>A0A0N5C5Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osteopetrosis-associated transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Q0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0001327700.1">
        <property type="protein sequence ID" value="SPAL_0001327700.1"/>
        <property type="gene ID" value="SPAL_0001327700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019172">
        <property type="entry name" value="Osteopetrosis-assoc_TM_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644">
        <property type="entry name" value="OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644:SF2">
        <property type="entry name" value="OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09777">
        <property type="entry name" value="OSTMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895450" evidence="2">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001327700.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35282" checksum="9308FE40A03184E2" modified="2015-12-09" version="1">MIKYYLITNILILLIVLSKEERLREDWDLNSPCQPYIEKFSVAISKMTECAANFTSPPKVCTNCIDQYINFKELEYSIKNLNNVTSLDNTTCSQVVYGQYLLSYVKNMADSLTFQVWDNSRCDSCLIIKWNFEGGGSKILYDDKTIEFQNKIFAWRNCASNASSTEPNICKRCSKVFDNLFEYYWEIYSKPEDDFCVDVETTMNDTMNIWHNIWNCTDDSRNNRIYDSTMLLTSTSFFILSIIVFYVGSYIQTERKPGRLENYSARPPIQVPRSRLLSSSTYNDSNSEHSYVNPNFTSIITED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6N1</accession>
    <name>A0A0N5C6N1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6N1"/>
    <dbReference type="WBParaSite" id="SPAL_0001359700.1">
        <property type="protein sequence ID" value="SPAL_0001359700.1"/>
        <property type="gene ID" value="SPAL_0001359700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF12">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="173"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001359700.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32251" checksum="13EC68B19FDFB9E7" modified="2015-12-09" version="1">MDITLIQLFFVVFINFSFLPLIITGCVNKIEEKSSKKSKSKSKSNKPKKQNDIYINTTILSTNSSNKPKAVPNASNRSKKEASLPLVPVKKQSQQNIAIKPQKSCSGQTLPVKNKEESVKSLTSTQSTSSKHSTNSFSLSNPVKLNTQEKSDQRKKLKLEKNLKEWQSKNYQQILVTLNKSELRWDDGTGGLQNVNLENPSRDRVAVKIKCSDNILYRVNPVYTIIEPEERITIDILRDAGTQKTDKLVFVLSKVDSDVKDAQVYYSGCPKRQQMLVLPLIGASAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Q6</accession>
    <name>A0A0N5C6Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ThiF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6Q6"/>
    <dbReference type="STRING" id="174720.A0A0N5C6Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0001362100.1">
        <property type="protein sequence ID" value="SPAL_0001362100.1"/>
        <property type="gene ID" value="SPAL_0001362100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001362100.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40335" checksum="50F1D30D4F739109" modified="2015-12-09" version="1">MDGKKKTNNGLSKDEAELYDRQIRLWGLDAQNRLRDSSILIVGLTGLGAEVAKTLLLCGVKSICLYDNGLVKENERISNFFLESENLENKKRSEAVWSQLKDLNPLVQIYIEKDCLPTSEEFIQQFDLVIVIDQPKELTSQINKVCRNLGINFQCGSVFGWIGYCFFDYNGKKFRLKKKKVDVTYSVTSEANKCQTLSKTDEVIIDDDYEEKIVNYKSFEESFQFNVDWEKMPRKKKRLFPVDIFILKACMALKYNIEVKEQIEQLKEEYRKILVENNAEHDPKLNKNNFANDEMKFYCNPQYNGTCSIIGGILGQQAISILSQNTLNIGVKNVFIFSSISGKGSVHQIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C858</accession>
    <name>A0A0N5C858_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C858"/>
    <dbReference type="STRING" id="174720.A0A0N5C858"/>
    <dbReference type="WBParaSite" id="SPAL_0001411300.1">
        <property type="protein sequence ID" value="SPAL_0001411300.1"/>
        <property type="gene ID" value="SPAL_0001411300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001411300.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="44472" checksum="667BB10681426065" modified="2015-12-09" version="1">MTVEAFKEKLSTLNKCFVDKITEEFNKTPHADFTPCLMDYIKHLGGIDEECCSHCTTNNGIPSPKISVQKAAKNPLLPTNVPKLPPPEPVKSGRIGGKLKRKASSNIENELEDNEEKVLDKNSIFAVPASPKFTKPAEPKTSLFGNSEKPQDTQKPVSLFNFGTIGSKAPSTNIFTSPPTSGDGKDKNATEGKSLSSFGINDSTNIFKKPEDPKDEKSTAKTSFPSLFGSSDTSKPLFSFTSNTTFNEKKEEKDGSSKSTLPTFSFKPTPVVEEKKDGEDDKNEEGSDEGDEPQEKYDPLQADKDAIYNVKCSLHQLVEKQYIKKGVAFINVKEMDGKKILVVRATNAVGTILINTHINENLKTAKLEGTKIRLSFPNSDGSGMETWVTRVPGASDVEEVLENLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C962</accession>
    <name>A0A0N5C962_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C962"/>
    <dbReference type="STRING" id="174720.A0A0N5C962"/>
    <dbReference type="WBParaSite" id="SPAL_0001444500.1">
        <property type="protein sequence ID" value="SPAL_0001444500.1"/>
        <property type="gene ID" value="SPAL_0001444500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311:SF6">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311">
        <property type="entry name" value="PROTEIN CBG21698-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895568" evidence="1">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001444500.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25342" checksum="BD830C43250D4B81" modified="2015-12-09" version="1">MKFFLYLIAFFGLINQGFGQVSNAKCLGYLKSGQQAFNKRLGIDMTLDWTKPEALRNTVESTYVLSGFYGLREACLALKDFKNVFPWDQSTYSQCFDPSKLIVDDNGQSTGVSVIQAKNYIGFMSATEYACGAGFNLFANQASCIATSFGSQNSTIQNCRSAFIKQINADPNNLCDYTYNLDICYLLAFSECGLEGQFFGCEYSRNAISATYQQCQNNMCFVNRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Q4</accession>
    <name>A0A0N5C9Q4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Q4"/>
    <dbReference type="WBParaSite" id="SPAL_0001463300.1">
        <property type="protein sequence ID" value="SPAL_0001463300.1"/>
        <property type="gene ID" value="SPAL_0001463300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001463300.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="74824" checksum="42EC3A9EAFF435AD" modified="2015-12-09" version="1">MSFTKNAEAEILANLGILTNQHLSREGSHRDSITDIKETSNRTRLLSSSDNDKSSLNFDSDDDGVVVFNNSNSLTTDYSKKIIKMSNWQSYLVVLPIILFMSYQIGIFHSLPEGYQNELYKFSSASFFGGLIAPISMSKSSFYVTNVEIKTPQLITKRDISVNMEINTTTISTESINTLKIISNDDFQSTTTYINLNQSTRISKPDSVVGVSENQDKKTEENALQRAAAEEKRKKNESETQSSFISIKSTTDTEVKSTGDERSTSATTPFTTSSNSIKENNATTKLTNKGVEELETTTITTKESKTTKSSEDLLLQKTTEKVIEVTTQKTKIIGGPYSVRQDFVIDKIYLLENLLLVLLLSIVPSLFFVILDLLKVKKLPNDIILKFVESKTYSSLPLRGIILSYIIWLLLSIIECTFAYCQINKLVKNKNENLFLPMLPILSLLFVRFIGIFYCKKLVTKRMIHFVQVISIFCVGGALFIISNYKNNKTDSQRNVQYLNQRNVQYLNGILGLLIGSISPVYFNWISKMVQKQTISLLNHFIIAYLGSILIAKVLFTYLLKDIDEGKVENSLYIVLMLLILLEITFAFLSLHLSSYYRQTEIARLTNYLSGNSRKQNGDASVKIKKNKYGYNRLVNETEHNFDSLSLIVSDSDGDSNDEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAL5</accession>
    <name>A0A0N5CAL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAL5"/>
    <dbReference type="WBParaSite" id="SPAL_0001493600.1">
        <property type="protein sequence ID" value="SPAL_0001493600.1"/>
        <property type="gene ID" value="SPAL_0001493600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001493600.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="21121" checksum="A1539EBCBAE64BDF" modified="2015-12-09" version="1">MVFENIVVFLFIITFGIIDVGVQCKREQLYITGQINCHDRHPTKIHVGIYQKTFLKRYYLLSEMSCRCGEYFAINATESRISARNKYFTMGKFIRPMPIVVLTYDYTYVNIICKVRAKVYLPKECKDGKHFGKIYQLNAVDISNVAYEEMDCHRIRRWSTIRKKSSYSIDRSRFSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAR5</accession>
    <name>A0A0N5CAR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAR5"/>
    <dbReference type="STRING" id="174720.A0A0N5CAR5"/>
    <dbReference type="WBParaSite" id="SPAL_0001498400.1">
        <property type="protein sequence ID" value="SPAL_0001498400.1"/>
        <property type="gene ID" value="SPAL_0001498400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001498400.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22994" checksum="C8C49411E40D22EF" modified="2015-12-09" version="1">MLTRIFKRQTSSKEEPEKTAFEGTFGSMKRSWLAEQKDAKEFSPEEQAQISYAMSTVNIIFGIVGFACLALGAWLRTDSRFREVLSERYRQAVAEAFWQAPTLYAFSYILIVFGAIEYRQNGPPERTNSRFLKIAPKEAQKPANKEDSRRDMTNRGRGRGRPRRNSIVSPPPTSKENNTKTPQINASWQMSEFKFMNECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB24</accession>
    <name>A0A0N5CB24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome assembly chaperone 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB24"/>
    <dbReference type="WBParaSite" id="SPAL_0001508800.1">
        <property type="protein sequence ID" value="SPAL_0001508800.1"/>
        <property type="gene ID" value="SPAL_0001508800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001508800.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13734" checksum="D12B1159D89859A8" modified="2015-12-09" version="1">MLIIILVVMGEEIQPSVDFKLELESCVLNVKVIVLEFCYIIYIGKKNSIEIMTMGNFGRSTLLDLSPGACSQMYVEGLNLKLSKAFPGKQIFISTDLSNDDSPEFWSEIFSKFVPKLKEVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB52</accession>
    <name>A0A0N5CB52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB52"/>
    <dbReference type="WBParaSite" id="SPAL_0001511500.1">
        <property type="protein sequence ID" value="SPAL_0001511500.1"/>
        <property type="gene ID" value="SPAL_0001511500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="6"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001511500.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55355" checksum="5B06BFDA3ED5EDFA" modified="2015-12-09" version="1">MTSAVLHVIVVGFHHKRGCQIEYCYPPINNSCSPKEEDIPKEWVNLPSLALPDGAHNVDKDVVYFLLPSLDEHNRSVFGISCYRQIAADELVAKEKDVTRSTVQKSVCIISRIPLYGSLLSKLEIITEAYFNEKDFSKVDVLKQMYKNLSDMFHMDIKNDETLIEAADIPLNCMLNTFKGRVLMLFKLILLEKKVMFNIFPTHKLGNSLFGLISLFPSLTQYGLFEAAHYSVLQRKSNLVESVNEEEKLKMSSCNTMVVDDFGFPLSLFVKGYLFHPYLSICYMDMIKSHNVRAFCIGTTNTLFNHRRELFDIMITLNEDDDLVIDYLESDLKKKLHLTTADLRFADYIAKQSSYQGSEISWEGSDDWIRFQFRAYLLSLLSTSISEDKDLLEDFNTDFINEWKCTLNYRIWLSKTHPGFDGVVPGHPFARQLNIGDLKLKMSQHITDSEGGRRIVNNIATTSKYVSDAGSKMKSSISSWFKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC12</accession>
    <name>A0A0N5CC12_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC12"/>
    <dbReference type="STRING" id="174720.A0A0N5CC12"/>
    <dbReference type="WBParaSite" id="SPAL_0001542100.1">
        <property type="protein sequence ID" value="SPAL_0001542100.1"/>
        <property type="gene ID" value="SPAL_0001542100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF1">
        <property type="entry name" value="PEZ, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="789"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001542100.1"/>
        </source>
    </evidence>
    <sequence length="1170" mass="134447" checksum="C53410D7095D8C44" modified="2015-12-09" version="1">MILNPLKLRLGRKHGKYEISQDIFVVTIFISDRSLCQCTLNSESTPFTIIEFLQQKVNLEQVFYYLNLIDFIPFLLFKPEFYGFKYQLKCNDPDKKIFRWLEFDKPVKKQLDKYACKPRHIQLAILYWTVNPSMLCDKMSRSIYFYLVKNDVINGKFLIDIEKYLSLAAYSLQVEYGDYDPHFHTLEFLKSLQLLPFHFIKNGQVGEEYLLQILTLYERLTSMNSSQAAILYLVDVASSPGYGEEYFYCKDDDSTETSIGYSFNGIIVKKYHTDNIFIPWSDIKSISSSKRHLVIKRKQGTTYQYLFEDTTSSKYTSIIFNWQYKYSTTIGILQKNMPIELKNLEEDMVVFVDNPKITIQTSNLNRSNFNHKISNTGEIIENISPQQLSMAFRNDHMSLKSSSYSHSSNSISITKNTNNGIKGIIGNDMLSQQQTFMQQPSSIRMSEFEGKKFKIMGSSPEINLITRNHNHQSHDSEGSHLKFIKRSSDRGRRANLMAAGAAKAKQNGSSNLYSRSTDSIEDNNSIHVHFQKQGNKFRSTPNLATIKYPKMGISSLKLQNNNNNMISSTSSPPPYIKSPIITQKKYSAPIISQKMNSHSPPSTSVVLSTSNIFDNLTSYYTFYHDKQQISQGDNIDSGRDSLSIDQYNDKIMSSSLEDECNDKKATNEDGNYDEKELGHGIRYHIDTLNETRNLTKTHSCNENLSQRRRPQLRRQDSCDLKSTHGDEDQFSFDSSSPDNFVTYTNTTSSPVHEDFLDTMEGIKCQNNLCFGLEDTLRLLLKKLSNSTILNKEFNDIPKKRHTAGTSTSLNTHNLNRNRSNYILPYEDTRVALVTTKDNIDGYINASNVRIPLGYQFLHYIVTQNPLSNTINDFWQMVWEKGVYVIVMIQKISNSQTVPIYWPTKIGEKLKLPMFSLRLKTTSKYNNVIILKCLKTGKKKTIYHLQYSDLDDYNIPLSSESFLAFLDTVNSVQRHVYNTLKDNEKIIEHTNRLSTTIRKKSSRSRSVSRVNLHDVTNKLRSLSTDQRKASTITMASSNIMNLNNLSLVNDQKSNNSFCTMTDSVNSSKGSSQNSYNDSGKGSNVGDDDKNKQVRRNIYPPMLVHCIDGTNESGVFLLTDVILKCLENNIPFEINQILRIMRQQRMSLMQSVGQYRFVHSTISHYLQRSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDS5</accession>
    <name>A0A0N5CDS5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDS5"/>
    <dbReference type="STRING" id="174720.A0A0N5CDS5"/>
    <dbReference type="WBParaSite" id="SPAL_0001601900.1">
        <property type="protein sequence ID" value="SPAL_0001601900.1"/>
        <property type="gene ID" value="SPAL_0001601900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF111">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="16"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="646"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001601900.1"/>
        </source>
    </evidence>
    <sequence length="948" mass="108645" checksum="4F43C93C305DBBC8" modified="2015-12-09" version="1">MSKAGGVDPGVCTDFIILPPPNITGKLHLGHALTIAIEDVMKRFAQCTGRKVLWYPGFDHAGIATQTVVERNLWKEKKQLSSNLTREEFIKYCEDWRDKRMTDIRYQVDKLAPLIDWDHSYYTMDGNFSNAVSTAFIHLYNKNLIYRDKRIVNWCSSLQSVISDQEVKKVTVGSGDALVVPDLHGGSRSVKFGRLFRVKYRLEGSEEFVEIETSRPETIFADVAVAVNPNDGRYGHLLGKYVINPLVKGKHLKIVPSDKVKMDFGTGMLKLTPSHSQVDFDIVTELVKKGKLEKKVLNVSCIDNNGRIVAPDTQFDKMDLFEAREEVINYLASKQILQETTKEGYQTEIPICERSGNVVEGTIKSQWFMKTEDLHNDIRRLIENGTIQLNPEFHYTKLIEWLSNTDPWCLSRQISWGHQIPAYKVSGTDRWLVGHPEDESIKKSVFELVRDTDVLDTWFSASLIPIVTGGWPGIPRPRKLSFIETGHDILGFWVARMLTVCYGITGEIPFDNIYLHGLIRDSLGRKMSKSLGNVIDPLDVVDGISLEDMLKRIRESSLNEDEMKIAEKDLETKYPNGIKGMGADALRYALLRHDVTSLDINVNILEIADEGHRFCNKLWNMTNYANNVLSMPRKKGKYLNSTNDMDLWIKSRLKSCMTNVYEILIENFKPHIALNHVTSFILNDFCDLYIESTKRAVKSGDRDRIDEIASTMYSTLGTTFKILSIFMPQVSDSLSERIVKAFGSERAPFDDLDFDIHKSLYNYDGNLEARVSDMYSVVSVVRSIRNTFNIPRKEQKLKCLLEVDREIESFNVLENVLSVAEELCNIQCTILKEKDTSLSDGHLRFRIPSTEMSLYIEMPSKYLQKTLDDYLSKKESLLKKKNKHLEINRSIQRHLENPAFQAKPRKIIDMEKRAKISVDKIQKIELELEKLEKDIVDIRKKIDQNSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFC5</accession>
    <name>A0A0N5CFC5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFC5"/>
    <dbReference type="STRING" id="174720.A0A0N5CFC5"/>
    <dbReference type="WBParaSite" id="SPAL_0001656100.1">
        <property type="protein sequence ID" value="SPAL_0001656100.1"/>
        <property type="gene ID" value="SPAL_0001656100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="260"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="375"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001656100.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53148" checksum="3B51573BF89C2029" modified="2015-12-09" version="1">MANPNYQNRGVKKQSPTFHILRILIPSKYIGSLIGKNGNHPIREIHIASNTKCLVDKNGPFTIFPNLIVKTITFVGDIEGICKACQLVSDFIRNAEEGHGVVHKNYEIFVRFPNQFVGKLIGKKGNNIKKIIEETNSQINVSSDAFIVSIPSTLCRYIPESLSNERTIVVSSDDVSKVMGAIRVISEIRHEMNVNYKEKNIPPYTYGYQFPYQTNNPPNFEADVLRYQGNVYQHQFLNILPTGGQIFQQNNLMNQIKFPVFNTLKIFIPENSVGAVIGTKGSYIKFIISQSGAQIKIESSSEHNRHINEKPKDSKKLSNDANVSSENLSNKKEDALINNNTREVLITGYDPNIQYAQQLIFLKVADATSSHIDKLKLTIEIQIPHGITGKVIGKKGKNVNYLQRITGTKVCVLEETILNNNIKSTLTKVRVNGTLAAISNIQFRLQKIIVDNMNERVKYRQRNNETFIQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFK3</accession>
    <name>A0A0N5CFK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFK3"/>
    <dbReference type="STRING" id="174720.A0A0N5CFK3"/>
    <dbReference type="WBParaSite" id="SPAL_0001664000.1">
        <property type="protein sequence ID" value="SPAL_0001664000.1"/>
        <property type="gene ID" value="SPAL_0001664000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="90"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001664000.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63854" checksum="CE6E14DB92BECBE0" modified="2015-12-09" version="1">MSKNSNEIILEMGEDTDLSSISLDESDEEQTKKVKVRKILVPKKGDDNFINATWVDTPKTRGRKKALNVLKKIGFEKSLIRDMKDKPIEYFFGLFFSDEMLNMIVHSTNIKISKISSEKCTDIVELRAVIGCLIYLGTFNKPPIRDIFKENYLYNSHLLPIRNTFSRERFSFILKNISVGEKLCKESNIVDKANQIRKFEQCFNLISSSLCSPESITIDESLIGFKGRCCFLQYIPSKPDKIGLKVQMAADSHKRFIYCIELYGGRRITEDGEIIQNTGLEIVKRFILNYFSKATGFTICTDSYYTSLNLLYFLKERNIAFIGTIRQNRKEVPQEMKHNAKRTLKSTIVKYLDNDASLTSHMCKTKKTVLILSSEYHDTLPIQGEKPASVKRYNELKSGVDVIDNMVKTHTTRIKTQSWVRAYIFRIIDFAMCNAYSLYKESSHSECSRIEFHRKVGENLMQPIAMTRLSNIYLPKNKLRNIENFVNTDNDGDNNTNEINTTINKRGKCYECQENNEKKRKTIKQCYKCNKNICISHFNIICFSCKNSHNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG54</accession>
    <name>A0A0N5CG54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG54"/>
    <dbReference type="STRING" id="174720.A0A0N5CG54"/>
    <dbReference type="WBParaSite" id="SPAL_0001683300.1">
        <property type="protein sequence ID" value="SPAL_0001683300.1"/>
        <property type="gene ID" value="SPAL_0001683300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF288">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001683300.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="31360" checksum="86400654BA327FA7" modified="2015-12-09" version="1">MDEKSTTSTFNSNSYLINEEQRQMKRVAFFAIVVSTVAVIASVVTLPMIYSYVASFQSHLIMESDFCKTRSRDMWSEMSVLFKNTPSSVRAKRQYGSPNPPTVSSGYGPVANPEPAPTCCTCQQGPPGPPGPPGDDGPDGTDGNPGIDGTNGRDGAVLGSAIAAEPCIICPPGPPGPQGQPGLKGPRGPKGADGKNGSDGKKGERGLQGPPGSQGPMGPVGPKGAPGQPGRLIQINGPAGPAGAPGPQGPPGAPGVAGPPGTSQQGPQGPQGDAGTPGPQGRPGAPGLPGIRGPTGEQGTCEHCPTPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGC6</accession>
    <name>A0A0N5CGC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGC6"/>
    <dbReference type="WBParaSite" id="SPAL_0001690450.1">
        <property type="protein sequence ID" value="SPAL_0001690450.1"/>
        <property type="gene ID" value="SPAL_0001690450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001690450.1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7595" checksum="7DDA2E185286AE41" modified="2015-12-09" version="1">MAQTQDLYFIDYFAPDDELTIFDNFGAKNHFRLGPHSFKKIEEIKGRKKLIHADESNCTNTTIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGT3</accession>
    <name>A0A0N5CGT3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGT3"/>
    <dbReference type="STRING" id="174720.A0A0N5CGT3"/>
    <dbReference type="WBParaSite" id="SPAL_0001705800.1">
        <property type="protein sequence ID" value="SPAL_0001705800.1"/>
        <property type="gene ID" value="SPAL_0001705800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001705800.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="8801" checksum="3BF8975AAA09F4A3" modified="2015-12-09" version="1">MADASKSPRTAARAGASSGTVRQRRSGGGSSGTSTARASNGGWRFYTDDAPGMKIGPVPVLVISLAFIFSVFVLHTWGKFTRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH68</accession>
    <name>A0A0N5CH68_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH68"/>
    <dbReference type="STRING" id="174720.A0A0N5CH68"/>
    <dbReference type="WBParaSite" id="SPAL_0001719000.1">
        <property type="protein sequence ID" value="SPAL_0001719000.1"/>
        <property type="gene ID" value="SPAL_0001719000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001719000.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="55823" checksum="57A20D4AB6A39F44" modified="2015-12-09" version="1">MVRTTTSKRSLMTMGQKVFVDYKLSLRGLEKGTDDYNKSIKETHKRSAEKILKLCQLNGGTFIKMGQLIAVMEYLIPQEYTSTLGELFSAAPKTEFDDVKRLVEKNLKKPMDEVFSSFDREPIGSASLGQVHIATLKDTNEKVAVKVQHPKVLLRSNIDLKTMEFFAVAAKNLFPDFNLMWLVEETKQNLPKELDFLHEAKNADAVRRMFSHLTFLKVPEIKYNYCTKQILTMEFCEGKQINDIEYLKRENINVHDICSKIGRLFSEMIFSKGYIHADPHPGNLLVSKDKKTGKVQLVLLDHGLYSTLKDNFRVMYSELWLSLMKPDLKEVKRISTEMGVGELYDLFACIITMRSWESIQQGIKNKKKDEKEVEHIKSYATQLASRINEVLANMPREMLLILKTNDLLRSIEYKLGVSNRADSFIEMARFCTSSVYVEKLRKVDNTFSYFKLWLNMYWRLLKIEIYSRFLMIKDFIWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI79</accession>
    <name>A0A0N5CI79_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI79"/>
    <dbReference type="STRING" id="174720.A0A0N5CI79"/>
    <dbReference type="WBParaSite" id="SPAL_0001753800.1">
        <property type="protein sequence ID" value="SPAL_0001753800.1"/>
        <property type="gene ID" value="SPAL_0001753800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="375"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001753800.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51698" checksum="C3C56AEF1B437F3F" modified="2015-12-09" version="1">MSLNDNDISYDGINCTNKDSGYKIGLDELSDLINKDINQSCIGRLKITRFAMIINVDNIQFKDNFNMVVIKNDRVQINMKIINECVKSLAKEVDMDNNCKRLLLFITFDVSEGMISQFYIEEFHKLDNLPENAVDLYFTSQNNKFSKLSKEKTDNVINTQNVTQNEIKYEESSNVRNIQNVTPNEEKDEESINVRNIQNVTPNEKKDEEPSNVRNLQNLSLSEKENLIFLPGQNIISPLKDGSTVFLFDDEDPFETPKTRFRNTSTTKTRKRKGSKTNEHPKKKKMLSPAMSYQSADENTDSLKLSDVIYAIELGIISSGTGGVKVEAVKKFLGISHLKLARYFFVNHLSSIYESISGLPPAVLATIPQIQRSDFTFKHLIGQGAFGEVYEGVLNVGKVEIIVAVKTLLATATQDSIEDFALEDFTMSRFNHSNIIKFFDCILDEPPRYLVLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIA1</accession>
    <name>A0A0N5CIA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CIA1"/>
    <dbReference type="WBParaSite" id="SPAL_0001755800.1">
        <property type="protein sequence ID" value="SPAL_0001755800.1"/>
        <property type="gene ID" value="SPAL_0001755800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057086">
        <property type="entry name" value="GBD_Irg-7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057085">
        <property type="entry name" value="Ig_Irg-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006582">
        <property type="entry name" value="MD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324:SF1">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23623">
        <property type="entry name" value="GBD_IRG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24415">
        <property type="entry name" value="Ig_Irg-7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00604">
        <property type="entry name" value="MD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895916" evidence="5">
        <location>
            <begin position="27"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1455"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001755800.1"/>
        </source>
    </evidence>
    <sequence length="2097" mass="235795" checksum="49C2C73C3A3B5D59" modified="2015-12-09" version="1">MVLLGKYKSFFTSIILLLLIVNLNNAEFDFEDLRLIKEFTKTWDFNKNVTIKSSLLRDNPKKYDTIRYANDGSSCQQPGYTGQYCEFPICQSSNHEHFDNDVVSVLVDFIHQPTCNKSAPLFVDISMFSFTIEIHGPSNNQPIISVYDRNGTLINPFSADTTDPTKNIYTYSTQNPGVYQIVPSTNTPDLGCFIYVAAIAQSHIDVGFVPSTPYDSIPPERNDFPVRNPYLNQLNTIVAHTTNIRQPGAITALSIFENYNIMSRPQKFSIRYGCEYDYYYNSLFCHNEDYYFMKVEGYDFFGNSFSRIKSFSCRINPNPPTAPPPTTTQNPINPTQCQNNGTLVKNSDASSYCFCKNLFTSYDCSKRICLNNAQPLDDGSCLCTEGFTGDHCQDVKCSAEPGVLPPQHEHKPIFVIRLRGKMTVYIKQLVDQIKALSSDLLSVQDHWFQNFGVITFNNNGATYDSQSFTSVEDFTQYLMNISNNNDASGDCNDQVFSSIVSAINAFQPGSRSPIYVLTDAVPNDSQYFDDLSLLNSYYQSPIYTFLFEDPSCSAWDIYSNEWKLMQQTSERFSGNVFQVYNREQDKFGSIFYNHMSNTYFKSELMYGNDLNVCSSLDRYNSLAVDSGFDTLSVVATGTDIDLQLTAPDGTPVLVNPVVQTTSITIWRYTGLQSGQWQFHIIPHLATTSCSIRVYSVINVPGHTFTPYYRLNWAFSDQINSDALFWQPLAKQGSSFVAHLDNYGLNDPMKVNAELVVYSKTDSNRSMTSASNGLWRDGCTFQMYFAPLRCYNLGETLYFTLFVELVQCSCQNSGFLLNGTCVCPPQYTGTFCETPICQNGGTVVSDRCSCPPLVSGMFCEFIMCPDQPITPEPLRKKQSITFLLDVTYTNRFFLQQLATYSDVMIRDIISHDGAIVDYIYIVTFDDSETPMVLGLTDTNNLGYVRQFFVDAYQMALGANTDCVTAKVWQALNLARMLNDPHSKLFLFQSSIPDEESEIALEFYTNVYDRFIENRLTLSAYIGATGQQEYYCAGGKYSFTLIETLTKSTYQGEYLEISYSAFMNVPKVVPSFVNSGIAYKKTFTDCMRNCSIYFSVDSHTQNIKAVVKGSTGGFDVTFIMPNQSVDTTSYGLIQDSTTGYWVMETRKECEDGWQTLGPQYCIKLTSQTASWYDAYNDCLQNNAFLVDDLYASKDNYLTAYLGDYNISSIWLGLTDDPQYSDGNTWTWNHGPLGNIPLSSAHFTNWNSNANLTDPTKLCAYKTRTWDTDNCLNTRAYICQKHSYRDNFSPSISESEKLPPGKWNIKLTSTGKTTIEVRVQSRIRVLSGFLNDIHGDTIDFNANILSSTQRMATHVSGYGDNIFNTYMVNSRMFLLNNTMFEAVNYQTRLSCTYQYLSQVFSCPKNGLTSTDFYALTTGVDELGYTIQRYTAHRCVKEIKKCNHGVAYNDLCICEDSWTGTLCDTPICQNNGTYNSLTKTCTCPIGYSGAACDKAMCFDRSPIQISRDGKIFALVIENTQENLIAINSLKKSISDTLRSLNPKWFDQYIYVTFDSTNQAILKNFFDLSQFLASIQTIVPQDDTTSCPQFYYHTISGDSGCTTDMSDKVVSFLQQYTIGSGGNFFTTTGQDIGRAFSVIIPSLYHGSVLGHLTFFNHSCSQGLTTYVYISRNMSDMYFYIYGKFPVVSVRSPTNDTLQPRTMFSGQPTGTSPRLYIYKIPDLTDYGIYTTTITSSGDCYAQIRNTGGPEIYYGFVPSSIDKLDIGNHLDNATVAPMNDYNHFVASVVGDIAAVEYVKMYNSYTNEGQYLKFYRRLNCTYQYYSDPFKCEKGLLQLKVFARDNSGFTITREGFTQCTQYIATPTYQPPMTTTTTTRKPEIITTTTTTPRGIITPTSTPPAAFTAKANIYLITDVSASVPAKKYANTLTNFLMELFNKFKIDPKYVNIAFSSSPGDNDTWYTLPVFNAFYGSEALRTSINSSYYPLDGVQSPGQKQLGDVIGMAFNPNFLNTGYDPSFKPHWIIYVTTTSSPDSNTIATAQKVRDKGLFKIVTIAYQPVDNIHALSSMSDCFYPVLEEGELSGLATVLAAKINLDSSKGQDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIC0</accession>
    <name>A0A0N5CIC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wsv008</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIC0"/>
    <dbReference type="WBParaSite" id="SPAL_0001757400.1">
        <property type="protein sequence ID" value="SPAL_0001757400.1"/>
        <property type="gene ID" value="SPAL_0001757400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001757400.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="21621" checksum="4D776041FA960C5F" modified="2015-12-09" version="1">MFGFITTAVKLGASLVSKVIAPIFGSSGSSSGGASEGGSGGSSGSGGGGGSTFGGNPSQPIPLANPPPNMSITNRHSMKSNQELISSNKVISGNNLTADNRATVDQAINVVTNVDNSDKGGLKKDIIIIIVCAVMLIITLAAVFLSVMVRKYKKRKSTSVENKVAVLKPASLSSESRLRKSSVSSSASKSKVTRASSRSQTKTKSKKSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIL1</accession>
    <name>A0A0N5CIL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIL1"/>
    <dbReference type="WBParaSite" id="SPAL_0001766600.1">
        <property type="protein sequence ID" value="SPAL_0001766600.1"/>
        <property type="gene ID" value="SPAL_0001766600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001766600.1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4099" checksum="307EACEEF277F2CB" modified="2015-12-09" version="1">MEFSGSLNHVKRILQSMHNVGASTVTCCINGFGSIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIU6</accession>
    <name>A0A0N5CIU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CaMBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIU6"/>
    <dbReference type="WBParaSite" id="SPAL_0001775100.1">
        <property type="protein sequence ID" value="SPAL_0001775100.1"/>
        <property type="gene ID" value="SPAL_0001775100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001775100.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11339" checksum="079ADECD0436140A" modified="2015-12-09" version="1">LKNISTKMDNLKKEVDQLLNLQSVSERKVNMLSVHLKQLKAKTDSISHEIKKKINTNGDYLKDMWEKQEKNLSKLRSVVVSILEIVPDYFDNNQPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1S8</accession>
    <name>A0A0N5B1S8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1S8"/>
    <dbReference type="WBParaSite" id="SPAL_0000003000.1">
        <property type="protein sequence ID" value="SPAL_0000003000.1"/>
        <property type="gene ID" value="SPAL_0000003000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF19">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893613" evidence="1">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000003000.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36060" checksum="4FF6C94601E18D9B" modified="2015-12-09" version="1">MLIYLLFITFSAIFTFSNCEIKDNEILRSNNKYNETVALLALDMAAASYSKNPRKCLKKLGGKLKRHWRSKCDYIHDECWGFIGIVDEYIVFSIRGTRSKLQLIVELIETMSRPKQSFPPGGAVEVYFYTALKTFWSNSSNVLVNLKKKYPRKKVLFTGHSLGGAVASLASALFVHQNKDIFGEDNLKNDTILITFGQPRVGNYFFSLQHDSLVPNSWRIIHRYDLVPHIPGCYEYGRKRSCVPAFNHSPYHHGTEIWYPLTMNGSSEYKICSGLPINEDDNCSNRCFLHYDINDHLKYFEHDISSYGDKGCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B299</accession>
    <name>A0A0N5B299_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B299"/>
    <dbReference type="WBParaSite" id="SPAL_0000020100.1">
        <property type="protein sequence ID" value="SPAL_0000020100.1"/>
        <property type="gene ID" value="SPAL_0000020100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000020100.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38283" checksum="AD8A1D6F873AA084" modified="2015-12-09" version="1">MEDLDLLSLPPEILAKIFSNIPWNQLINVKLTSRKFNYVTEKYLKDMQKPKISEIHFHNVYSYIDEIDRLEVTYEILRTDANSCGNINRFMNTKFDLLPSEIDQLHSFLKKVDLTSLNLVDINLDNHTEAIRIFNGYFHNTNKIDDIYFVVRDSDKNFDDILSFLQKIQNVGLLYLHLPLPHQNVPRDFIIPVRNSLEILDIYERDDTAFFNPRIIKYIVENNPDLRLYILSFDNFKTYKMVIGTILKGVLSKRNNSCLHNCITLSFDLFKFEETSELLSYLYSEEFPYNATNNMRKENILYTGELRCPVCGKFDSIEIFDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3I5</accession>
    <name>A0A0N5B3I5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3I5"/>
    <dbReference type="WBParaSite" id="SPAL_0000063800.1">
        <property type="protein sequence ID" value="SPAL_0000063800.1"/>
        <property type="gene ID" value="SPAL_0000063800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000063800.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45475" checksum="6438BDD873F78B43" modified="2015-12-09" version="1">MHSKYFIIFFNLFSLIYCYKILVVNPKFGYSHVNFFSQVADILTEAGHDVTVLTINIDPTIKHPGAYKAKIITYPSTKEVEDNFANMIDNRFIWSLSNDGAQQFKFAMKFIDALHKQSLRVFNDEELVEKIMKEKFDLGITEAMNIYVLGMFKVWGIKAYVTGYSMSLGDHFYKFFGLPFPASFIPNYMSSSTDKMTYSERFENWFVHNFGEFMGYFLRDKMTLQSEFDKKYGVGFYDSNSVVGDSSFLVLNSNPFLDIPGPKTPKMVEVSGIGQKCGIVMNKFELADSSKLITNIKTILDDDTYKKNAKMVSRRLNKRPIGSKRLLIEHIEFAAEFGKLDMLDLASRHMGIIEYYNLDIILPVISGFIVFVGLIFFIIFRIFKKLFTKKLKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Z6</accession>
    <name>A0A0N5B3Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-RVT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Z6"/>
    <dbReference type="STRING" id="174720.A0A0N5B3Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0000079800.1">
        <property type="protein sequence ID" value="SPAL_0000079800.1"/>
        <property type="gene ID" value="SPAL_0000079800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000079800.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23295" checksum="D6DEB81A181D0F1D" modified="2015-12-09" version="1">MNYVPLEIRLGKDCYKFSNVDDAKKMFKKHFKKVFIEQKSEKFNRNLEYGKWRLKCKDEVDSDWIRGDISIKHVRKLFAASEGQTITKCHWKFGSNEFVDRKCRHCGQAVETVYHILNRCEKFKKSLFVSRHNNMGIAILRRVLKKYGFSYVKGKKIYKNNNAEIFFDTLYPLLSQVVASNPDMVIIDKQRRKSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B407</accession>
    <name>A0A0N5B407_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B407"/>
    <dbReference type="STRING" id="174720.A0A0N5B407"/>
    <dbReference type="WBParaSite" id="SPAL_0000081000.1">
        <property type="protein sequence ID" value="SPAL_0000081000.1"/>
        <property type="gene ID" value="SPAL_0000081000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="80"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000081000.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="34159" checksum="BE7F53906B0B8BAF" modified="2015-12-09" version="1">MPRGNLIKKFQNQKEVKEKNKAKKIKKEENDGEDRAKVITRTIENTRELCETMINLEDDEIIHDQAHDEFAPYFERQTTPKILMTTSMHAKTLTFDLMRELEMVIPNVEVHSRKLVPIKRIVEQAIENEFTDIIVIQEDRKKPSGMIFCHLPDGPTAYFKINSMTPSKKIKHVGQKTNHYPELILNNFDTRLGFTIGRLFASIFPQDPEYKGRRVVTFHNQRDYIFFRHHRYEFKRDGTRAALHELGPRLTLRLKWLQKGTFDTIEGEYEWVYKRRIQQPNRRTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4N7</accession>
    <name>A0A0N5B4N7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4N7"/>
    <dbReference type="STRING" id="174720.A0A0N5B4N7"/>
    <dbReference type="WBParaSite" id="SPAL_0000103800.1">
        <property type="protein sequence ID" value="SPAL_0000103800.1"/>
        <property type="gene ID" value="SPAL_0000103800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="328"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000103800.1"/>
        </source>
    </evidence>
    <sequence length="926" mass="102564" checksum="6D5C6C27916C534F" modified="2015-12-09" version="1">MKKVYTRTLVLSLIAAVCLAIGIALTVIGAINISKGVKNNSDGDNKTTTPGTDVKSTTTSNGGTGMSSGSTGSSITTTTTTTIPPYYYPPRSGIVFGIISGGEIKPEVFEYIVQEMIPNIITANWTQPQRVGALCYSKYPPNQVVPFNEPDYDTIKKNISSFTWTPNITNISTELNQIRQLFLRQLPLEDKYMQTILFTGISEKEDIENSITDGMMLNESGQLIVIGVGRSVDKNLLKKLSNNVLIWYYGGNEKQITSQVEEMIVGFNPNSFSTTTTTAPSTTTMVSNVTSMTTNSFLTTTTPSPTKVPVIQTTTTNSPIIYYPCFTDIILAIDTSSDVLSPLQFQEQISLLTIDITSLWTHYERVALTSYNNNFNSLYTFNTIRNHTDFTSKINTFTQSEGSSLTRLLAGLLTLETDSSGQLSIFIFISKLNYADLQFAKAYASQLLKKGKLNFIILDSNVNPYDLVSLNASKIVSYNFTKESLPGVKSFFETSYSCSFVPSTPWPLTTTTIPTTTSTLAPTTVSSNYYPPKSGVVFSIDSNKNIDTNLYQSLKTMLTSNIITSQWTYSSRVGVLGYDSNDNTETSPFGLPNFLAIKEMVNNFTPLSGGCSISIGLLETKLQFYTSLQDDLKYMQTILFTSCSDMNDINNATVDAFFLREMGQLIIVGFGGNVKKENLLKLTDKVIIWNGDLNDSNFINTLEGWIVGFEPSTFNTSTTPPTTPGGSFAPSKVTKNPNTTSLPPQIPYYPCQTNIILAIDASSDVLTPDDFSQQLDLIQNTITTNWTHYDRVALSWYNSVPSTFFSFNTIEDRSDFNIILKSLITQGPGSSLSKLLSSLVYLQNKNNFKTSTFVFISEVDLDDIEKSREFAEKLLKEGYLNFIIIGSNLTPQQLTRLLSLNPSNIQQWDFSDNNDVLRFFNNSFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5E5</accession>
    <name>A0A0N5B5E5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5E5"/>
    <dbReference type="STRING" id="174720.A0A0N5B5E5"/>
    <dbReference type="WBParaSite" id="SPAL_0000128800.1">
        <property type="protein sequence ID" value="SPAL_0000128800.1"/>
        <property type="gene ID" value="SPAL_0000128800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000128800.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29307" checksum="10D2A91B692B05D4" modified="2015-12-09" version="1">MEETTKIINKFNKKQKKSTVSCESIIGKDDNETSGNINLTQSDSNIQVNEESEQNIQSLNEPICSISSENLIENNSSKGGISRFTRNSTNRLRDSRRCHANRQKLTRNTVNNNSVKKSNSKENSTIQSHLHNISSHISKSNLMKSSPKSTLRRLSSSVSSLIEGKYIFTVSTSPKNKNNLKETKNDLFLLTNFSVSPYHRSNTVRSSIKKDENLDEFVDTKLCVSFDEVNEKTDGLIDDNISYSFKVFKKNVMFYKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5H1</accession>
    <name>A0A0N5B5H1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5H1"/>
    <dbReference type="STRING" id="174720.A0A0N5B5H1"/>
    <dbReference type="WBParaSite" id="SPAL_0000131300.1">
        <property type="protein sequence ID" value="SPAL_0000131300.1"/>
        <property type="gene ID" value="SPAL_0000131300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000131300.1"/>
        </source>
    </evidence>
    <sequence length="804" mass="91371" checksum="7F479F8F27B04A08" modified="2015-12-09" version="1">MLKIVPCKDNDVIPKKRSRISIGIQDDECKGIEIGGVTVQFPGQFDPYPSQTSIMEAIITSLDNSSNALIESPTGSGKTMALLSSSIGWLKSYKNKIKLSKMNCKLHSNENNKENKLNNDESFDDNDNLKNEGGSLCQCTCMNSVKIFYATRTHKQIAQVIKELKRLPYCYAQDSENIHHTILSAKEQSCINLDVRKLKNINQKCRRINADEKSRCIFKTNFNRCFDDSNITTLNDILPVWDIEELNEYGTTNHICPHFAALKLFRNGADIVFCPFNYIIDPKIRDRMGIDLENSIVILDEAHNIENFSRSSSSFNFTEDEIVKSLDDVRIRRNSLKKLLGGDSPMDIMIEEYNIGNTRPNEQEIAYLTGCLPQMEYLLEFMNKLFEWFQNFAPEVLKEPIKMDVFTSKLLVYKTDPLELEKLKGALTCCSTIGYGENSVICSSTNGLDEWQEGDESYSEVTEGDFIGDRKCEKLKENCVVKLELWCLDPSLGFKDAFNNVRSIILASGTLSPIDTFISELGLKFESIVQGDQIIPKEQIFASVIGVGPNKKDIICTKNKISAGEQKNGNSVLFEIASLIVDVCENVKKGVLVFFPSYSMLEQVFQKISTSQLMAKLEKVKVVLREPRNSNSNSLNNVLMKYEKAIKQPESKSKSCTGSVIFAVYRGKFSEGIDFADDLARCVISIGIPLPNIGDPQVIEKKQFNNKFRVKKNLLPGDEWYKIDGYRALNQALGRCLRHRDDWGIIIMVDKRLREDIEYNSLDKYKISKWVVDNIKSYRSYEAFRKQMITFANAREKLSVPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B675</accession>
    <name>A0A0N5B675_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B675"/>
    <dbReference type="WBParaSite" id="SPAL_0000156400.1">
        <property type="protein sequence ID" value="SPAL_0000156400.1"/>
        <property type="gene ID" value="SPAL_0000156400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000156400.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9717" checksum="3273DC6A47DB2CC1" modified="2015-12-09" version="1">MENKNIFELVFSQLIQNKRNMYVNVITFGIKNNCMKYKILCLHFYKFYITCYKTISKIVKFIANKIYGNKLLISQLNFSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6U0</accession>
    <name>A0A0N5B6U0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6U0"/>
    <dbReference type="WBParaSite" id="SPAL_0000177600.1">
        <property type="protein sequence ID" value="SPAL_0000177600.1"/>
        <property type="gene ID" value="SPAL_0000177600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF17">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894036" evidence="2">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000177600.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37409" checksum="CE34C1DD7A8F92D5" modified="2015-12-09" version="1">MTIKNTMLIILLYFILLSITIYGKEKLSVTKDIIHYCDPETPDTCGSKGVCIKKSSGNRCSCPDGWMGVKCQRPCQDIYKSCSKWLEERRCVWARPISPFFADNCPLTCGACRNSIGRALPLALPPILEDISWVIGKWETTQDSSNDFYDKRFPRNIDGGYKEILDIMVTEVPSFDRPGLNVSVTAKSIKKENIINKELGFITIKPFLEDTGFAEFNKPKSGPDLVALELSSNTGVLTIEEGIMKKSFDKSSNSNINILVLELKHINDYLYEKSEIKDSKRIFKYISRPSSSGRLVESLIEIGSIEKRDGQVLRWKKSYRKIFDYLTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B735</accession>
    <name>A0A0N5B735_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B735"/>
    <dbReference type="WBParaSite" id="SPAL_0000186300.1">
        <property type="protein sequence ID" value="SPAL_0000186300.1"/>
        <property type="gene ID" value="SPAL_0000186300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000186300.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25910" checksum="B5EB6915537403B7" modified="2015-12-09" version="1">MERNSEHYLEVISLSLSFVFSAKCCRFFLYAAFVNFVFLQYQSITKIAKYDTYIGVRELCSSDKECLEEYEKSFSGFPSFEVGFIWLILRLIVLFFIIMKTLNLIKDFNVNVVKVKYLVIKIGMYICLQTVDWMIRIMLVEKVYQKHFANTPIKVQWYKMTLDTVSSWLLFIMVLYIYWKQIKKMKAQRVETKVKGYLAYDTFTEYYAMQSRKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7E8</accession>
    <name>A0A0N5B7E8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7E8"/>
    <dbReference type="STRING" id="174720.A0A0N5B7E8"/>
    <dbReference type="WBParaSite" id="SPAL_0000197400.1">
        <property type="protein sequence ID" value="SPAL_0000197400.1"/>
        <property type="gene ID" value="SPAL_0000197400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000197400.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21912" checksum="8F489F011707B1BD" modified="2015-12-09" version="1">MEELDKKLFVNRLKKKLGLEEDDMEIEVAPFENTIINGRHFGENYQKSEKIKKHFERTGVLLDEDDFINENNGKNKDIVFLAKKSPYERDNDIISHFQFTEKIFHKRIGEGFFVADLKNIHINRNSKHKYYLQIYQKSYDEDVVDEVILGESLERFNDPTNKKLKLYIPEDFIIKMKNEMPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7G5</accession>
    <name>A0A0N5B7G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of epidermal growth factor receptor (EGFR) signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lst-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7G5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7G5"/>
    <dbReference type="WBParaSite" id="SPAL_0000199100.1">
        <property type="protein sequence ID" value="SPAL_0000199100.1"/>
        <property type="gene ID" value="SPAL_0000199100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15731">
        <property type="entry name" value="FYVE_LST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043269">
        <property type="entry name" value="FYVE_LST2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="488"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000199100.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="71664" checksum="06D295CFEEE22862" modified="2015-12-09" version="1">MQSILKLVRKPRMDDWSPLAKFYYADEALNSITLELESFDGRRDQARCDQLVQRLRQAQDRLIHIIYEMIAIIFPNEADRASRDYRVKFPDEIIHDSLPGQLWFGAECLAAGSNIVDREFESEQIRPIAKTLTKHLDQMRELLKDQSLRNPHQYTDKIKASLKVFDYLFAEFEFHYVSAMVPVKSVKEHDAQLDIAVLFSETLNKAMQKKYITQDQIDMFDPNVMFAIPRLAIVWGLLYYPEGALNVDREPQQLSEMFRQYCHLLLTMRSLLRDMSPEELRQLEMTLVTGECITTPCSKKSSKQCEPSTSSSSISEMERKLSGEPNDFTNDGKVLKKDSNASDNDPESKIVSISLQDAIDCRVEIEHDAADDLRLLEAFQNMNLTEVYMRYEKSIQKKSRRMYKDRNELIHRLFICIAGVADQLQTNYSQDVRKLLKMVLQPNEIVPVYEVNGKTARVPENEEETGIEVQEETLPLPSFIVGVRWVPDEECDQCTSCNAPFTIIRRKHHCRNCGRIFCSYCSSSRLALPELGYDKKVRICDMCYYYKMNPTTTDPSLTSMRRDVQNSTYGNEENHLSPGSSDISSPTTATIARNCNHESGSNYTPSTTLTSIHEPIEGTNSISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7T8</accession>
    <name>A0A0N5B7T8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7T8"/>
    <dbReference type="WBParaSite" id="SPAL_0000211300.1">
        <property type="protein sequence ID" value="SPAL_0000211300.1"/>
        <property type="gene ID" value="SPAL_0000211300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000211300.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38130" checksum="D20BC9E59712ECCC" modified="2015-12-09" version="1">MTYHFTLAVTKYSHTETSRKFSAFLSQIRDAFSIDGVTDENIKFPLLRSRLDDKTREMIPTTKPDETFEQYLIRLAAIFDDTLITNDLETRYSFFKLNFSSDKFEKTLREFVQLHEAMYRDLPAELNFQSFRRRLLDLLTPKPNLFKVILNSTATTNPTLVTTLTPVSLQWTTSSYTKPLQIYPIQLPFYSTTYNSKKMTYHFTLAVTKYSHTETSRKFSAFLSQIRDAFSIDGVTDENIKFPLLRSRLDDKTREMIPTTKPDETFEQYLIRLAAIFDDTLITNDLETQYSFFKLNFSSDKFEETLREFVQLHETIYRDLPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B845</accession>
    <name>A0A0N5B845_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Protein kinase C</fullName>
            <ecNumber evidence="2 15">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B845"/>
    <dbReference type="STRING" id="174720.A0A0N5B845"/>
    <dbReference type="WBParaSite" id="SPAL_0000221800.1">
        <property type="protein sequence ID" value="SPAL_0000221800.1"/>
        <property type="gene ID" value="SPAL_0000221800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20835">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20838">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05591">
        <property type="entry name" value="STKc_nPKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000063">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000126">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034669">
        <property type="entry name" value="nPKC_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000551">
        <property type="entry name" value="PKC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="282"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="543"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="288"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000221800.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69358" checksum="0BFD4EBFF2A0F785" modified="2015-12-09" version="1">MKGIMNTIISILGNSSIFDKGNQKRSNDAGKPRVFRERTDAFNDRQRRGAMRRKIHEVTGHKFMALFLRQPTFCAHCKDFIWGIGKQGYQCQICTVVVHKRCHLDVVWKCPGNKGDAIDEIASDIHEQGLGRFNINIPHRFAVHSYKRPTFCDHCGSMLYGLINQGLQCSTCKLNVHKRCQKNVANSCGINAKQMASELAQLGLTGDKMSLKVKKKPNFQQSTSSDGDSSSVPSALSIDETKDRLPTSSNKSCLSNIKGGAYDPLQMSAPIRLPNQVSLGDFTFIKVLGKGSFGKVMLAELKGTDEVYAVKILKKDVILQDDDVECTMCEKRILALAARHPFLTALHSCFQTPDKLFFVMEYVNGGDLMFQIQRARKFDEARARFYAAEVTCALQFLHKHEVIYRDLKLDNILLDSEGHCRIADFGMCKEGINANKLTSTFCGTPDYISPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILHDDVLYPVWLSKEAVSILKAFMTKNPLKRLGCVQSQGGEDAIKAHPFFREIDWEALEARKVKPPFKPKIKSKRDANNFDADFTKEEPVLTPTDSGILKSINQEEFVGFDFVNCDFHYLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8P2</accession>
    <name>A0A0N5B8P2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8P2"/>
    <dbReference type="WBParaSite" id="SPAL_0000241500.1">
        <property type="protein sequence ID" value="SPAL_0000241500.1"/>
        <property type="gene ID" value="SPAL_0000241500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000241500.1"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112013" checksum="23209215004BBFB6" modified="2015-12-09" version="1">MKEENRMSTIVADNIDKVDDSVFKTPFLPSKKGNCKKSENRNNIGHLDEIPQGEQKSNIKKEIKESEKNDLVLDPFYNHKCPHTDSFIKKTWPDLSGSTVGDCEDLVIEVIIDDFSLLLFRNDDEYNEFMKAENNRQAKLEAERKQKEIEAEAKRRKEKKKALRRKLKLEKKMKRRKFEIESGVQSIPLTSEEKAERKRLKREMKEKRREERRSLRNQNKISGADAGNKKKCRGSSLSPVPLNSDVPSTSNCTNLDSKHMQSPRTNDGYSLLASNNNMKRPSSISVDSGIISGSPNSKLPKLEVDELKSSMLGIAVKTAEAVNVNKIPATPPSANTANGHSRTPTASMDIKNSLPNSNSIQNNVSVSTPQTQSNSSKQGLLTSGIQPTQCHPNNMMFMEILKTNPGLAAMLPNNTGLQVNIQNPALSSNQSQQLLHLQQIIHQQNTFANSVVQRGISSNNNPSNLIQQQMQMASSQLMPNMPVHNNLGTPLINGFAGQINAPVVSTPTRPAPPHGSQVINKTPCNFSDTHLKICMEISNAKCTTSNTSNGVQNSSNISSNSTNTIPTTVSNVSTSTNENKKTTCTLQASNPMPGITTGIVPSSSNTLSTPGKAVNNVIPTNPSTPSNLTPQQAAMIQAMNAQLQQVNNAKLVVGNQRPQSVMPNGGLFFNTSSGTNVPNNGVNHQALFSANMSNSNEAAFQQLMMQAALQTNGNITQIQQQNPLLAAQITAMQQQQQQNQAANIIIQNVVNAQNSAAANLLTVNTNQTPSSLNTSGDPSKSLLNSVNSKNVFIAQANEQKQKLLNICTNEILKCAQQIQHYQNLINTLQIPAEKEAAKAELMKYVAMHTELNNNLINIKNQLNTPLQQENLITTQQQLQAAAMAVNTNNRSQLSNNISIPNTMINNIPVDSLYEIQRQAVAQQHLLRQYQSLAGIQQFQQQQNQLNAAAVVQNASMLHNQYAQSQILQMQQLLAAQHPMFKQSNNSNSGNHNLDQLHRQRSSTVTGEIPNQNQNGVCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9I1</accession>
    <name>A0A0N5B9I1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9I1"/>
    <dbReference type="STRING" id="174720.A0A0N5B9I1"/>
    <dbReference type="WBParaSite" id="SPAL_0000269700.1">
        <property type="protein sequence ID" value="SPAL_0000269700.1"/>
        <property type="gene ID" value="SPAL_0000269700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000269700.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40871" checksum="F6B18D1D78BFCA98" modified="2015-12-09" version="1">MGKYQKDKTFSCEVARAMVDVLVSRNRDILYVPSYPGILSEINLKDSETSDSYVDRDVVVYIPDNNNINVIKGCCFRDSNEDAIICSSMDGNVYGYDIVQSQLLFKINSHYCVNDVCMIAPNNCNVFISAGPKSLNIFDSRILRTRSDVGAPIAIIGYNSINYRYISSRGDGNYVVGTCYDNAIKVYDIRYANKNIFNVLNNNQFNDLRCIGEVPIKKCQYVDTVCKAKISPQHTGSRFIYTGCYNENVSIFDLYTGAKVKTIKCTESSQVSTLDWHPFKNQIVAGATCGKVVCISDEKDSELIMEGGKNPDNDHGVDHNSNNEIPNDNRRRLSKIRFLGQEYERHFPRLPRRQIDYSTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9T9</accession>
    <name>A0A0N5B9T9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9T9"/>
    <dbReference type="WBParaSite" id="SPAL_0000280900.1">
        <property type="protein sequence ID" value="SPAL_0000280900.1"/>
        <property type="gene ID" value="SPAL_0000280900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF794">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="43"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000280900.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="49163" checksum="8F59B971001C8733" modified="2015-12-09" version="1">MFNDIFIKNTLKKLYRNYFYNFAFKKKGNCFNIERNIHYLKKRDINIDQKCKWDKTIEYYIGNGLKKDSIKEALYIISNSTCLKFEEQNTQFTGKKGLIFQLSAGCASYAGCIYNDKPQPVYLTYQCSSEIGRVLHEVGHALGLAHEHSRSDRDEYIKIHKYYIRSGAESEFKTINQKEFSNLSVTYDYSSIMHYGTTDGTWFEWFPTISSTKYKLFEFMMRQNKNMTFNDFKQINLLYCNKCNWLDMVDKKYKTTEKSRKWSKCYFGGYPDHRHDNCKKCICPKGYTGDMCRKVVESNKKDCNGTFFWAYDKRRWYMVYGAKKCFVLFKSDPKKKVKLMIAEAHARNSRPCTEDIGHQVKYLKDRGNTGLLICNNNYDTINVTSEGHAILLYYNGNRSNDYLIAGYQAVDSSTPTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAI4</accession>
    <name>A0A0N5BAI4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000305100.1">
        <property type="protein sequence ID" value="SPAL_0000305100.1"/>
        <property type="gene ID" value="SPAL_0000305100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024">
        <property type="entry name" value="BIOFILM ABSENT ON HEAD (AFTER YERSINIA EXPOSURE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000305100.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="35165" checksum="A6B5066FC290B3FF" modified="2015-12-09" version="1">MFMFLEKWREEKNVRIMIYYRSLSRDVFELLKYYEKLNIVYLIPSPIFPRNDPMQKFVATSGGMGPLFFNDCMYRNNTNYLTVMDVDEYFHIFDEQSRKKGLLEFVKKKSNQYPMIGFFNFQSYYLSYINKKVDDSFNFATEGLLTFDYPNKIGKSIILTSKISYPNYHIPTFKKLKDGYRFPKNEGILLHARPNYIFKNVESKDKIQFLGSPEKLKFNSNYQTLIKNLRETLIFKYKRTVISNRCILKNKKKSENYCNWNIEECGKQIDLLENWIYTSEKSKNYQEYVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAP5</accession>
    <name>A0A0N5BAP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAP5"/>
    <dbReference type="WBParaSite" id="SPAL_0000311200.1">
        <property type="protein sequence ID" value="SPAL_0000311200.1"/>
        <property type="gene ID" value="SPAL_0000311200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311200.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17392" checksum="28DE0145A4ACE62F" modified="2015-12-09" version="1">MMGMGGYGMGMMDPMMMSGMGGGMMPGMMPGMYGGNTMGMQGIDSDSFGQGGFRHSMHTGKKDSDGDGIPDDMDPEPLRPQSSTGKTVFEILIKFFCKFLALNRQGTNGTQNSGTNRWKSAGQQGIKINYYNVFKHSFYLILVIAKNRLRSSLNGTGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAQ3</accession>
    <name>A0A0N5BAQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFAP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAQ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BAQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000311800.1">
        <property type="protein sequence ID" value="SPAL_0000311800.1"/>
        <property type="gene ID" value="SPAL_0000311800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="4">
        <location>
            <begin position="181"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311800.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="50875" checksum="92A969693E876EF3" modified="2015-12-09" version="1">MNSLNKTVASRISKITTNVAAVPIKNEKGQVVMKKVKVQRYVAGKAPVCSDSDSDDSIEVVDKDEFDKIGTKSSRGTNESNVVEKYSNDIKDESESESSEDEEEIERRRMRLKAKIQKEEHDEMESIYDNDELELDDDEDNVKKRRALLKSQKLKDEDDEIQNDSKLDYESSEEESSEEESEEEDDVPRLKPVFVPRKDRVTLLEIQKEKEAEIEAELEEEKRKEARKQQSVTLLEMTLKAEKEAEEVKKLADALDFTEIVTDDDDDEIAYELWKIREMNRLKRDREEREMYAREQEEIEKLRNMTEEERDKYFEINPKIITNKQDKGKLKFLQKYFHRGAFFLDKDDEVLHRDFTESTLDDNFDKTVLPKVMQVKNFGKSSRSKWTHLTAEDTTDHQGAWAAKTNYNQKFTAKHAAGMKNIFVKPTSLKRKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC60</accession>
    <name>A0A0N5BC60_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC60"/>
    <dbReference type="STRING" id="174720.A0A0N5BC60"/>
    <dbReference type="WBParaSite" id="SPAL_0000360800.1">
        <property type="protein sequence ID" value="SPAL_0000360800.1"/>
        <property type="gene ID" value="SPAL_0000360800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF68">
        <property type="entry name" value="RETINOL DEHYDROGENASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000360800.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39508" checksum="9D180BEFD3C19533" modified="2015-12-09" version="1">MSTLSKIVEGLKSPWSIAFSVFGVTYGVYNVIDMTQSGEKYELKEDLEGKTYIVTGATSGLGKATAEELARHKARVIMACRDRNKCIQVRRDIVLATKNKNVYCRGLDLEDFDSVENFVKKISKGQHEIDRIDGLVNNAAIMERNREVNKAGIEKTMATNHMGTFLLTGLLMDKLLKQANNVRIVFLNSNIINRECNLDINDLNSEKDKFDGFKVYKKSKLAEALFAKELSERVKDTNINVLMTDPGRSSTSLAEKYDGKSFFLSRWILKVVSIFMGERKPGKAIRPVLYALVDSDSFDMNGVFLDRERKEQEWPVQSEDGMLRKQLWVTTEKWTKFYDHLKNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCK9</accession>
    <name>A0A0N5BCK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCK9"/>
    <dbReference type="STRING" id="174720.A0A0N5BCK9"/>
    <dbReference type="WBParaSite" id="SPAL_0000375500.1">
        <property type="protein sequence ID" value="SPAL_0000375500.1"/>
        <property type="gene ID" value="SPAL_0000375500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000145">
        <property type="entry name" value="Chromaffin granule amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000375500.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61240" checksum="444C68F51FEB95EB" modified="2015-12-09" version="1">MGIKELIARHRGNRKLLLLIVYIALFLDNMLLTTVVPIIPEYLLRISHPNQTDEILNKKLPANPHSVRGKRDVWGDDSWDLPMSPNDNIDFDESPFNPMKPSISSKYSKPKNTTSRKPLFKGKSKGKNKFSNKKKPIVKEESIEDYYLKIEAEKKLRHDTLSEENIQVGLMFGSKALVQLITNPLIGPLTNKIGYTVPMFLGFVVMFLSTIMFAFGNSFGTLWFARALQGIGSACTSTSGMGMLAQAYTDDLERSTAMGIALGGLALGVLVGPPYGGILYQWAGKELPFILLALLALCDGILQFFVLEPKIDRGEPEGSTMKQLIRDPYIIVAAGSITIGNLGIAMLEPSLPLWMMESWQASSFERGIAFLPTSVSYLIGTSIFGPLAHKIGRWLSGLIGLIIIGFCLIAIPGAESVYGLIVPNFLMGFSIGMIDCSMFPLMGHLVDIRHVGVYGSIYAIADAAFCCAFALGPFVSGPLVRNLGFPSMMYVIAAINFIYAPFMYLLKDPPPTSNQGSSNSEPPSINPKNLGSSNRYEFIEGVTNENVSRMQGYQYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDA6</accession>
    <name>A0A0N5BDA6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000399400.1">
        <property type="protein sequence ID" value="SPAL_0000399400.1"/>
        <property type="gene ID" value="SPAL_0000399400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894109" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000399400.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11392" checksum="594FF7A3C1E31835" modified="2015-12-09" version="1">MHFKVIVTLLLFTIHAAIEARFRLFRSKAFSVAIKGKLTCPHHRKGFALVMISFNKKPEVDKHPVAKHYAKFDLSFYLSKMFEYRRGYPREYNLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDJ6</accession>
    <name>A0A0N5BDJ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDJ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BDJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000407900.1">
        <property type="protein sequence ID" value="SPAL_0000407900.1"/>
        <property type="gene ID" value="SPAL_0000407900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000407900.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10121" checksum="14DA3DA6FF5408EC" modified="2015-12-09" version="1">LTMPRYCLFGDTVNTASRMESNGKPNHIHMSYDAHKLLTEKIGGFVTEPRGEVIIKGKGVMETFWLVGKVGEEAADPNNDTYADYKKESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDZ9</accession>
    <name>A0A0N5BDZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caenorhabditis elegans ly-6-related family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDZ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BDZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000422600.1">
        <property type="protein sequence ID" value="SPAL_0000422600.1"/>
        <property type="gene ID" value="SPAL_0000422600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF3">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000422600.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24619" checksum="3660DBE761F4BA46" modified="2015-12-09" version="1">MQCYSCMSPYLEDQFLYISHLYRKPLQFTERCDEARFNGDGIKVKNCSDMCVTLRMNDKVGGRRRHGYMRGCLSDILHYNRTVVRENPNCYHVRLRDLFVSSDRYSFEPTDNVMLCTCANKLLCNSGTSIIGGNSRKIKKFSQFILKNLFKTIGKEIHLDWRIENCVLFIFLTFIGLILKKVIFSCLDVEYFMEEFYLPSFIGALIWLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BET5</accession>
    <name>A0A0N5BET5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BET5"/>
    <dbReference type="STRING" id="174720.A0A0N5BET5"/>
    <dbReference type="WBParaSite" id="SPAL_0000450600.1">
        <property type="protein sequence ID" value="SPAL_0000450600.1"/>
        <property type="gene ID" value="SPAL_0000450600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="389"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000450600.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57340" checksum="2B9C5C3BC7636820" modified="2015-12-09" version="1">MNTFVYIDDILTASDNEKERLETIEAILKRIQDNGMKISLKKSSFGLLQINYLGYTIDFHGIKPNQDKISALEKKQTPKTAKEVKSFMGAASYFCIHIPNFARIAEPLYRVTNEFIWTAEQETAFQNIKKALINAACLKKPDSHGKYEIQTDASNQGIGAVLIQDNRPVAFIFRSLTKSEKNYPPIKLEAIALIYALRTFKSYIYGKQTQVYTDHKPLLALIKNKNLKGILERFQLAIMEFDVKIDYVKGPDNHMADYLSRETFNLIAALDAAFPVMQQPYDTPYNIKNFIHYYTAEDNFKYDGKPLVTVRNKNRFYVPEILREELLLRYHKHPLLGSHFGYQKCAEYFQRIFCWPEMIKDMKSVWEDCSECLANKEQPNRKIAVVKKHLERPNEIFKTLSIDYGVIEEGKYVLAVVDEFTKFAQVAITTNQGALTTTTELMKMFCNFGFPQTIRSDNGPTFKSTKFVAFLKELGIQHLTSSAHHHKGKSIAERFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF80</accession>
    <name>A0A0N5BF80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF80"/>
    <dbReference type="STRING" id="174720.A0A0N5BF80"/>
    <dbReference type="WBParaSite" id="SPAL_0000464800.1">
        <property type="protein sequence ID" value="SPAL_0000464800.1"/>
        <property type="gene ID" value="SPAL_0000464800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000464800.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="49324" checksum="54C559DB1B8D06E1" modified="2015-12-09" version="1">MKRCINLTNILRFILFILFISLIINDKEKTNDEIKKSKIKWLDTDLKIPKPLNNFIYEATRLNEFLATDTEICQNKNILDEIYDNYYYCWDEKYFYNITLRKALYFSGHNKTKILFGQKLNITQWYAFLMKNNPVINTLSGDTNFKAIDEMTYGNLDVWSMISLFHNDELLLTRLEPYSDIFVDKEKSYYKAVDIVDYLLPFIKSKFLQIEIKIGGKNASDITFQWYSLLYNLHFKYNFIVFGANSNGYCNRNYKGNCIFYISLVKDDSIITAPIFGLGSNDEERKRLITFIYQLPLKYKESSNYNLCETKNTSKTDGNIDAGSHLTDKELSKLLMNKEKCITIDLGGTGWRMMDAILRNCQKIKSLALKIYLWFGEESLHYRKYYGYLLKLEKCGLEIYLDTNPNPYTFIIVLDHSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF92</accession>
    <name>A0A0N5BF92_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF92"/>
    <dbReference type="STRING" id="174720.A0A0N5BF92"/>
    <dbReference type="WBParaSite" id="SPAL_0000466000.1">
        <property type="protein sequence ID" value="SPAL_0000466000.1"/>
        <property type="gene ID" value="SPAL_0000466000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000054">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000466000.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29313" checksum="755940C799FE86F3" modified="2015-12-09" version="1">MHISKHCLETNLVYSDATMFLTRSEYDRGVNTFSPEGRLFQVEYAIEAVKLGSTAIGICTSEGVILAAEKRTVSPLVIGKTHEKISQVDTHIGVAFAGIIADSRTLVERAQIEAQNYWFTYNKKCGIDDVTRSVANVALQFGDDDVKASMSRPFGVSMLFGGVDQEGPKLFHVDPSGTFTQCDAKSVGSACEGATHNIKEQYHEAITLLEAKKMALNILKLVMEEKISCDTVEMVQITPVKDEKGDQTGKFHRLTDVEMTPLIESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFN3</accession>
    <name>A0A0N5BFN3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFN3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFN3"/>
    <dbReference type="WBParaSite" id="SPAL_0000479900.1">
        <property type="protein sequence ID" value="SPAL_0000479900.1"/>
        <property type="gene ID" value="SPAL_0000479900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="48"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000479900.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45867" checksum="DA4EA00F7997C4E6" modified="2015-12-09" version="1">MKKLKTIIFSSNSFSTTSFLNRTKKLVLGIETSCDDTAVAIVDSDKNVLGRRNFSKKDSQIRLGGISPSVVGELHRKYIDRAVNESMDEAGIRFYDLDAIAVTTRPGIVVSLKVGANKAVNLSQKYQLPLIPIHHMRAHALSGGLDKHTNLKYPFLTLLISGGHALLAIVHSPVDFELIGQSEGGSPGECLDKIGRAIGISRLPQYKEYHTGAAMEEIAFEAKKVEDYTKYQVRMPSVNGCNFNFSNIKSSYLMLLQKVPIDSIDLVSMCASVQFTITAHICSKLHLALEKLSSEKSHVKQLVVSGGVASNQFIKECLSKVCKVHSIDIITPPKKLCTDNGEMIGWAGCEILNYYDTYGISCAKRQILYDIKDYIYVKDKELIGNDSSNNWGPIKSDKKIVLTSLLPFSKDLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFP3</accession>
    <name>A0A0N5BFP3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000480900.1">
        <property type="protein sequence ID" value="SPAL_0000480900.1"/>
        <property type="gene ID" value="SPAL_0000480900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 15" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="16">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000480900.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55116" checksum="79DA299DD69777D5" modified="2015-12-09" version="1">MVLADLGRRIRVAIGKLGQATVINEEEVKVMLNEVCAALLESDVNIKLVKKLKDNCFKKINNEELLGGVNKRRVIQKTVFQELLALVDPGVAPYTPVKGRPNVIMFVGLQGAGKTTTCTKMAYYYQKKGWRTCLVCADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVVIAADGVEKFKKEGFEIIIVDTSGRHKQEASLFEEMLQVSNAVSPNNVVFVMDASIGQALEAQAKSFHETVPVGSVIITKLDSHAKGGGALSAVAATGSPVIFIGTGEHIDEFETFKPKQFISKLLGMGDLEGLVEKVSEISNMQDSAELLKRIKGGIFTLRDMYEQFQSIQKMGPFNQIMGMIPGFGPDFLSKGNEQESQNRLKRMMTIMDSMADKELDHPKATELFQKEHTRVTRVSKGSGTTEIEVVELLNQYKKFADLIKKMGSMKGLFKGGDMNPMNMNPNQMMALNKQMSKMIDPRMLQQMGGMAGLQNCIFQNKAFQKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFW4</accession>
    <name>A0A0N5BFW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFW4"/>
    <dbReference type="WBParaSite" id="SPAL_0000487550.1">
        <property type="protein sequence ID" value="SPAL_0000487550.1"/>
        <property type="gene ID" value="SPAL_0000487550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000487550.1"/>
        </source>
    </evidence>
    <sequence length="61" mass="7522" checksum="255A8B7D71686724" modified="2015-12-09" version="1">MYYDLFSQSFWVFCGSKKPKKSISRSTYFSIVVICYYYMEMKRKNFLLLEILTNLSIFRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGT0</accession>
    <name>A0A0N5BGT0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BGT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000518000.1">
        <property type="protein sequence ID" value="SPAL_0000518000.1"/>
        <property type="gene ID" value="SPAL_0000518000"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000704400.1">
        <property type="protein sequence ID" value="SPAL_0000704400.1"/>
        <property type="gene ID" value="SPAL_0000704400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF19">
        <property type="entry name" value="UPF0046 PROTEIN K07C11.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000518000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000704400.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19297" checksum="44BB29A49E753301" modified="2015-12-09" version="1">MDKIVIDPRTELYSTDELWDNFYSKERIVKKVKFSCHLNDKPENSVRIVCISDTHNKLSEIAPFIPPGDILIHAGDFTNFGSIEEIDKFNDDLQKLPHTYKVIIAGNHELGFQDNEDESLRDEIYLNKGTKKGYERLQNCIYLQDKTIEVSDIFKKMFPQIVGQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHC0</accession>
    <name>A0A0N5BHC0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="11">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHC0"/>
    <dbReference type="STRING" id="174720.A0A0N5BHC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000536300.1">
        <property type="protein sequence ID" value="SPAL_0000536300.1"/>
        <property type="gene ID" value="SPAL_0000536300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="353"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="669"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000536300.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121661" checksum="043994C8DA0209DD" modified="2015-12-09" version="1">MLLELLESICENNQTKIVDFFSPNITLSQSLQTFASCYQNNLMVIIPALFLFIFFPILMFALHKSKNPKLEVCSPVGGRITIGIILITITAVQFFYNTYRKWYSSKNIPLSWIYSTGVRYISLCFALFLTLACRNRGIVTSGVLFNYWLLLLVCSIPEFIGKYNYYFDNSDIFKNLFNNKFEEFGSADDNLLQYSTIQNILFIIYFPLLIVQVILSCFVDTPKYHVTNEKECPEYYTSFLNQITFDWFTPMAYTGFKRALTADDLWNLNSSDESKNVVSQFNKNFNNEMKKFAMKKIRKQKKEKRHGKIIKLEEQQLTNENQVSSKAKKDSEENTDAPSVLWPLFLTFKMTFIGSGFYKLLFDLLQFVSPKLLSVLINFIQDKQQPLWIGLAISIVMFLVALFQSMVLHQYFHNMFRLGMNIRSALISTVYRKALFLSNTSRRKMTVGEIVNIMSVDIQRFQDMTTFVMLFWSAPLQVLLSIYFLWDLMGVSVFAGLVVLLLMVPLNSFISVKMRDCQVKHMKLKDERMKMINEVIGGIKVLKLYNWENSLQETITAIRKKELINLKQFAYLHAATSLSWSSAPFLVAVITFGVYVTIDPQNNILTPQITFVALALFNILRFPLAIFAMIFAQAIQCYVSNKRLKSFLAADEIDPNDIETRINSSGKALTIKDASFSWIKETDPFLKNINLSIEKESLVAIVGRTGSGKSSLLSALLGEMTKEKGSVHINGSIAYVPQQAWIQNLSLKDNILFNKTYDEKLYNKVIDSCSLRQDFEALPNGDLTEIGEKGINLSGGQKQRVNLARAIYADKDIYVIDDALSAVDAHVGKHIFDNVLSTNNGLLKDKTRILVTHSLHLLKYCDYIYVMKDGSVSEEGNYSQLIKNNGELAELLEEFLIEEAKTRGRSVSFGEDAEEVKEVLDHLEGIDPIKKRRIEKELLKTVEEIHTSSENIFDKEETLSQVNDSREKETSKLLDNSNENKTKNVESLTKGQIIQKEGVETGKVKLSVYVSYFKAIGLFCTFKFIFIYLLSSILGVLSNLWLANWSDNAKKIQSSNNTDETNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHQ1</accession>
    <name>A0A0N5BHQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000548800.1">
        <property type="protein sequence ID" value="SPAL_0000548800.1"/>
        <property type="gene ID" value="SPAL_0000548800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000548800.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21941" checksum="EDEFE8DA040AF274" modified="2015-12-09" version="1">XVDLFWITRGKGSHLGGCRLQMPSVTGGIFHGLQGEGRSIWRFVGYRYAFGQKVWIFFGLQGGRAVNLEVVGYRCLQSQFTGVDLPWIARGKGSHLGGCRLQMPSVTVYRWDLPWIARGRAVNLEICRLQVCLWSEGLDLFWITRRAVILEVVGYRCLQSQVWIFFGLQGGRAVNLEVVYCFFFINIFNYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHQ5</accession>
    <name>A0A0N5BHQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHQ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BHQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000549200.1">
        <property type="protein sequence ID" value="SPAL_0000549200.1"/>
        <property type="gene ID" value="SPAL_0000549200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894276" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000549200.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26347" checksum="29E6C6BE26B89505" modified="2015-12-09" version="1">MYNFYMNYYITIITLSILFFQYHALENNVENDDNALLNFIQNDLFLKNSINQDSMIHSISENKYLKKRQADGKGGQKKSVVKKTSKPKVPLKKPLKPTASKPSTKKPVVKPQALRKTTSKTTRRTTSTRRPPTTTHKRSTGKPTRSTTRTAPKTTSKGPVVPPKKPAPITSMSKKTSRPSTTTKTSTTTKSSRTTKSPATTKSSITTKPSTTSTSTSTSKPTPKINLEPNADKKLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIC6</accession>
    <name>A0A0N5BIC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIC6"/>
    <dbReference type="STRING" id="174720.A0A0N5BIC6"/>
    <dbReference type="WBParaSite" id="SPAL_0000571000.1">
        <property type="protein sequence ID" value="SPAL_0000571000.1"/>
        <property type="gene ID" value="SPAL_0000571000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000571000.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21952" checksum="7E130C1911F9D903" modified="2015-12-09" version="1">MSNNSLSLINIESSILFVCDVQEKFRPSISHFNEIVTMIQRLIKACNILDIKIVGTEQYPKGLGHTIEELSIVENKIKVFEKKVFSMLTDDIKKEIGKEVKTVILCGLETHICILQTTKELLQNGYEVIIIADGVSSRTIGDKKIALRHLEKIGAQIRTSESILFELIKTADHPKFREIQKIILTPAPDTGLSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ18</accession>
    <name>A0A0N5BJ18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ18"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ18"/>
    <dbReference type="WBParaSite" id="SPAL_0000594466.1">
        <property type="protein sequence ID" value="SPAL_0000594466.1"/>
        <property type="gene ID" value="SPAL_0000594466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000594466.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8433" checksum="EB41513348450E09" modified="2015-12-09" version="1">MNVGYKCSSPRVLKTHCDFEDYPIDNKCKYIYIVRNNKHFIVIYYNHIKNLSFYQYNDGSFDDFFLIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJV1</accession>
    <name>A0A0N5BJV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000621975.1">
        <property type="protein sequence ID" value="SPAL_0000621975.1"/>
        <property type="gene ID" value="SPAL_0000621975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000621975.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11953" checksum="CCC3FAA5E556D0A2" modified="2015-12-09" version="1">MKLPEVINKVYRSTRSVAKVLKELLLGEFGGFQNPLVRFIELMQCDLDSTDPENALTELRTKYTVLDTKLSKNKIQIRMLMNFLAKSSNMVYLEIEKVLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK51</accession>
    <name>A0A0N5BK51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK51"/>
    <dbReference type="STRING" id="174720.A0A0N5BK51"/>
    <dbReference type="WBParaSite" id="SPAL_0000631600.1">
        <property type="protein sequence ID" value="SPAL_0000631600.1"/>
        <property type="gene ID" value="SPAL_0000631600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052861">
        <property type="entry name" value="BPTI/Kunitz_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248:SF7">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248">
        <property type="entry name" value="PROTEIN CBG06772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894498" evidence="1">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000631600.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22596" checksum="3938C87E7A7C17A2" modified="2015-12-09" version="1">MKFKRNYIRIFFITFVSLTILKQCAEAVDEKTQYCNLPKSPGNCKDKIQRFYYDPIWMMCLAFVYTGCDGNGNSFNTKAECEHSCLRSDGTSCLGPNKPKPVIKQGTDCDSTECPEGYKCARGAFHFECCHETDYKNLNEAYESKCPDGSEASGVFTFYFQPTIAKTCDDLVCEDGKKCVQVNSDFAKCCGAPTGNKTSTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKA8</accession>
    <name>A0A0N5BKA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKA8"/>
    <dbReference type="STRING" id="174720.A0A0N5BKA8"/>
    <dbReference type="WBParaSite" id="SPAL_0000636800.1">
        <property type="protein sequence ID" value="SPAL_0000636800.1"/>
        <property type="gene ID" value="SPAL_0000636800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="174"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000636800.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50138" checksum="3109C5E14E9EC52A" modified="2015-12-09" version="1">MEKVHNESSNISNGTQKNVKKQRKIILPENSICSICGDKATREYYGAISCSACMCFFKKCLDDNVQLACKFKGKCNITKEKRTKCKYCRLKKCFDSGMRREHWEKNKKHYVKKFKSTKFNKKKANDKLSNKVFEIKASTVSPTNTTDMGIKKDCSKEDKSQLVQNSSIQSMSQPEETILDDLVECENIMKHPKKWHCYKAQIFFETTADNGEIVYSDGLIKPLDAMLESSVQWADAIGKFIDLQADDKALLTEKFVCKNIILSLMYRAMENENIIDAIEKIINEKYDESDDKRIFNKYFGKKLRELVKKMIRLRLSHVELIIIKAALFLNNNANDLTSDGSDCVLVLKESVIESFVKCRRYDFLTCSIRLYDLINCISPILDILSKMIMKNKILRDVFNFNNAGALIEQYIGESSVTSEDEIKEGNSTEDDSMDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKN9</accession>
    <name>A0A0N5BKN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000649500.1">
        <property type="protein sequence ID" value="SPAL_0000649500.1"/>
        <property type="gene ID" value="SPAL_0000649500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000649500.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22873" checksum="E2F610612F12B7CD" modified="2015-12-09" version="1">MNKRPKSFYSASPIDNAQYSSKRQENSSRSLSKKYERFYENPKNVKDAFNFYNNRHDKIEVDDGSPKPMENDLDVEQPRMESPERKISRECNSSPVKLSSLDKAEDRFIIKVVHGGFCRIFTYRRSYGFDYFRSQLYTQGKQPYKGPCSWFDYQNDRISLIDENDLNSMLDFFELAGERYIRVFLNNPSNNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL85</accession>
    <name>A0A0N5BL85_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL85"/>
    <dbReference type="STRING" id="174720.A0A0N5BL85"/>
    <dbReference type="WBParaSite" id="SPAL_0000668600.1">
        <property type="protein sequence ID" value="SPAL_0000668600.1"/>
        <property type="gene ID" value="SPAL_0000668600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="46"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="90"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000668600.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46086" checksum="24A7A4914AE05034" modified="2015-12-09" version="1">MNYFIGKGITNDYYKDCLNKKMFLPFLFSLISLSIAFESEDNIYLRRDKRTIEIKHNFNYSNPMNYFIGKGITNDEAIKKALLHLEHYTCLHFKESDSELKNDGINFEFGNELSVSGEKYKDKLSFVYLTKDCMENIGCMKHMLGHIFGLNHETARYDRYKYVKIYWDRIDNKSKSTFQRDNGYNTRIFNTAFDYGSIMMPPLRYGTKNNQKAYETLESPYYENMVGQREEYSHNDLKKINDVYCGGLCVRKAKNCKHGSYPSPDCGVCNCPLGYAGKTCTALASSFGNCGHTSLSATRKVKTLVLKGHVKCIIAINSKAGTNVAITVKSMKTDKFSPCVEGRGLEVKYRHDKGATGLCLCGSYKNVPIPPTFSAALVMFHGNKDDHELHLTYQEVKRKKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLB7</accession>
    <name>A0A0N5BLB7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLB7"/>
    <dbReference type="STRING" id="174720.A0A0N5BLB7"/>
    <dbReference type="WBParaSite" id="SPAL_0000671600.1">
        <property type="protein sequence ID" value="SPAL_0000671600.1"/>
        <property type="gene ID" value="SPAL_0000671600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF46">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="244"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000671600.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39768" checksum="4C1ED6729BA0E160" modified="2015-12-09" version="1">MATINSRPIDKTGSISPSECLDTNKKSKPVGIGTKPKVATPHVVAKIEQYKMENPTIFAWEIREKLIAEKVCSQPPSVSSINRILRTRASERAAEELAIMLSQRTQGFLTEDGSQLSTFPLAQMLPHNNSLINMNLLNNIHNRTNTVPLFNYTPSIINTPIPSINLLSNPLRDLCLQSTFTNNINPTNLLIQNPSQIYFNNKSTTSLANISQGLTQNKKNNMNDKDFKISPDTLALSSKTPEGYCKKQNTLQFNMEELKFLENEFLRNPYVTNSTLKKLSKQLGVEESKISIWFSNRRSKSKKNDSNFCKDDSVIENVLSIHKRKIMSDDNNVEVSKEKKIKKEVIFKPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLQ0</accession>
    <name>A0A0N5BLQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000684600.1">
        <property type="protein sequence ID" value="SPAL_0000684600.1"/>
        <property type="gene ID" value="SPAL_0000684600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894478" evidence="1">
        <location>
            <begin position="21"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="437"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000684600.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="68864" checksum="DD5A4CEB0D8BC153" modified="2015-12-09" version="1">MNIFLIFSFFATCFINLVEVQEVAITYTTRYIAGPKKLYIYCGETYFSPYELKEKILDDFYFVEPSHLLLTEINPQDVSVGFNPKNHKFRKVIDSALQITLLKYLIIVFCGKKGPIFVINGKSYYTFGFAERRVKHLIWKDRKSKEFRPYLPLHPPMKDNILGNKKIFCYRFWKTLWGSCDYYCYSKNRFGVMKQKFLTEIGYYRWKHGSENLVENERLSQLALKLLRSMISRKYRVDIKKYENVGKGNRYTAPLIINRWYGEHKDYNYITGGYSPNTSHFTAMVWKNAKQIGIAILQSANTIYVKVIYDVAPKKEDSYIKNVLRPFLSEINYYRMKHNASGLVENQHFSNVAQHSLSILLRNTRKMNVKRFDNIGKGNVFTAPLIVNEWYGEHKNYNYNSNIGSRGTRHFTALVWKSAKQIGFGVVRKGDRIYVKFYFDKSINIPNLYRQNVDKPISSRFRDPRLSQLAERSLERIILREKKIDPTKHENVAKASLDLAPLMINSWYRERKDYDYKSKHGNLTAKHFTAMVWKSSKAVGFGIVKVGHSIYLKVVYDTLTNLPYQFRKNVHKKVKKRKYWKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLS8</accession>
    <name>A0A0N5BLS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000687400.1">
        <property type="protein sequence ID" value="SPAL_0000687400.1"/>
        <property type="gene ID" value="SPAL_0000687400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000687400.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47778" checksum="545082CEE48C4E7C" modified="2015-12-09" version="1">MTVSNNKDKLRWLINDDEEYESIVTRDEHSEKSNKNYDSTFLSKKIDEICENFLATNNFNVKTKNSYFNSIEEILLLLCKNVYNFVDVVGQLTVKKKINAVKDSNLLRFDIDASPLYKRDVFKFDTTCYTIPIKEDITKYLNDSVHLDENETQLSLALFLDEFNVSPLGSYKLINIKSLKYLQSSTKKHFRSICVVQSVIASQNWEKFLSFICKQINFSVLINGIERYISLKFIVADNVGFADIYKIVKNYKSSCKQQNCKSCLWKGIEWSSKRTPNDISINLRKHSISYLPPNSNMCNDPFHDLLSNGVLYTATMLTLKNMLLLLPPLMSTDEIKNKLILEAKNRKFRNLRLVLFDKIFSKLTTTKRTSKAKNESHDVKSVNKCVNLNGNQTLSLGIVVFFVLKNTNFIQGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM31</accession>
    <name>A0A0N5BM31_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM31"/>
    <dbReference type="STRING" id="174720.A0A0N5BM31"/>
    <dbReference type="WBParaSite" id="SPAL_0000697600.1">
        <property type="protein sequence ID" value="SPAL_0000697600.1"/>
        <property type="gene ID" value="SPAL_0000697600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="8">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="6">
        <location>
            <begin position="438"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000697600.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56583" checksum="969FD4C45EE00A87" modified="2015-12-09" version="1">IFDIRNVLQSNNFNGYTDLPEVNFDIIEIDYVEDKDVLKRLGDENLKSANEEQRNFINKILNIIVNNLPDKRCFFLEGPAGTGKTFVYTTLYYLLRAEDKIVLNCASTGIAATLLRNGQTVHSMFSVPITLYDSNFRLSKLNKLRTTMLEKASLIIIDEAPMLSKYVIDYLDQQLKKVCKNDLPFGGKVIICGGDFRQTLPILPNSTRHQNVLFSIKYSPLWNVHFETVKLTRNMRVKEDEIDFAKWILDIDNDGLQKNENGEVDIPLNIQSTGNLVNDIFGAKNESILEKSNYAILAPTNVIVESINNEVLDTLPGDVDKIFSADSIRKDSDTDENYYNMPIENMNQLTPSGLPPHVLNLKINAVIIVLRNLNIKEGLCNGTRLRIIKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEYPFTLARKQFPVRLAFAMTINKSQGQTLSKVGIDLTTPVFSHGQLYVAFSRVKSPDCLFVKTESDKAKNVVYTEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMU7</accession>
    <name>A0A0N5BMU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000723000.1">
        <property type="protein sequence ID" value="SPAL_0000723000.1"/>
        <property type="gene ID" value="SPAL_0000723000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000723000.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27877" checksum="46344220525B2BB0" modified="2015-12-09" version="1">MLQDKETKNSKLVWNDFTVRRRESTLVNKNLYSVTHPRRTAYAGVKNKRAMSLEKEIEEMESKGRRVEEKVQRMRVRARNLEERIRILERRTQLIEKRTLILKENRRCGGKPKVRLTIEPGKPLNIAFCGSPSNDEDFSVSNCGLQMGGLVRSESVDVFDVASKSKPMIESQFCIDAPTVGNDNMMDVEKIETQNSGVKCILNGIQNLKLPRKQEEGFTNTDMSSTSNDSPNSVDSSGNNNFIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMZ0</accession>
    <name>A0A0N5BMZ0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BMZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000727100.1">
        <property type="protein sequence ID" value="SPAL_0000727100.1"/>
        <property type="gene ID" value="SPAL_0000727100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="17">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="16">
        <location>
            <begin position="722"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="1370"/>
            <end position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000727100.1"/>
        </source>
    </evidence>
    <sequence length="1649" mass="188224" checksum="5D7475E949AE3759" modified="2015-12-09" version="1">MEVLRRMKRNESFKKNETSLKKKKCHLCGEVDQHKRGSIWHKNKKKNEITKVPLTCLVDTGSTRIITTKSVYRAAIKKNSCNLKPVIFNLADGSVWPLKGVAEISLKFGSVKVNVEVGICRDEDFNFGKNQTRYSVMLGSDVLTAANANLNYGTNEVMFENILVPSFMEIRNLKKKEIRNVFRITSEGKNFRKGNKPPNKTSWGDVQEKAFLNTTKNLKGVCDLRVGIRKNGQCNQLEEIISVGDSENEKFKKHKSNVTWKEEYVMKRRLHNSHTYKDSKGNKGRYLARNHNHLKLEEGGSKALKKREVKKLWINRDSDVEEVPPGLNLDTDKEGYLSEEEVNTVIEKDISGLSVNTFVEEISSSVVVVKKTAKMNAWLCHPLYEDTKDVGEWLDGLKMSSMIDDVEERKCTYLAHLRGNDTIKKIISSYCSDVTNWSDLKTILVKRCGKGISKELSMMKLKTFEFKVNEGIKDQVIEFGKLIDVILPDELSSDLGMDIKKLILQTYLRDHNVLWNRCNDGKHDNMYELAGDLEMTWARKKSSSGNNFHGRKKFIDKKDNVKTEIKGSNGKCFGCGEAGHYKNNCPKSGDKVKKINGPVENAKRVEQLENMIEKLLEKEHFGEFVRRTNDLKNGTLVDGSKLTSRRADCKAEFYLPIGISYGSEDVKFKPVVGLVDTGSTKCIISRSTANLIGISCDFLRPKTYSLANNSSWRVLGEVEVQIKVGKNVVDVQVAVVPDSEVSQSHNKFQMLLGSDLLKACGIVIDFKNMKMYMDDKQLVSFNEVKANFVRLVRNVRRINIDMAQSIVKKFPEVMSREKTDIGECTISARPILFVEGAKFPKITRFNHNYEKQKIIAAQIKEWKNMGVLEEADAQIILNVTVVRKKEAILEEEIDGNVMQSRAVSGWRTCIDGRLANKILQYVSYGTKVLSQRLSQLQGATKFSNFDLRQFYLQVKMADVNLNQFGVQCPISNKVFALRRIPFDKVLMMAEIEICKTLMLDGEMEKIAPERKFGLFSYQDDIVFFTKKELESSHFKMVEIIFQTFKQVNLKINVAKMSLNVDEIQFLNFMVSAKGLAPCLEYVKAIQEVQAPVGKKSLQRFIGMVQYYRIFIDNITKKQLPLLKLLEKNSIWKWGKEEQNSFEMLKMDLINAAQIKLPDVMKRFYLFTDCSKDCEAGVLAQEDEEFGNALRPCAFYSKRLHCSGYTPSVLLELRALCNSLLYFKKLVGNAQVIAKSDHKPLISMLTNGKESSSKFMKYINLINEFGNVEVMFIEGKKNIPADFLSRAFVRKVMVNDSVKDSPPDPNKMKEIFHQYHDCLGHASLARCTPIVLLRHNWIGIKRDLANYIDQCSTCKVAVAKYKERMKVNVIVPSRPLQMLAMDVSGPHKISLSGHKYVLGVVDVFSKYLWLFPLCDIKTSTISKELETRIFIPFSSPIYMRSDCASTMLGGEVKTLMEKYNVIVDPGIVGYKQSNCMIERCFRSLNITMRKSLDNFDLWNEVVWSTMYSYNRLVHGTTLHTPYEIMFGQKPILKSDDRKEVEKIADFKDNEIIRSQTYLLVEQLIEAVRGKRYDEDSYEVTRCGNDDKLNVTDKPLGDLEKKSPLKKLKVGDRVIIRDHTSGKWDVIYSGGNDNAYIVKSLLKNGKNANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN52</accession>
    <name>A0A0N5BN52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Calcineurin B homologous protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN52"/>
    <dbReference type="STRING" id="174720.A0A0N5BN52"/>
    <dbReference type="WBParaSite" id="SPAL_0000733100.1">
        <property type="protein sequence ID" value="SPAL_0000733100.1"/>
        <property type="gene ID" value="SPAL_0000733100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000733100.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22446" checksum="6D8890808D35D363" modified="2015-12-09" version="1">MGNSSGSLLLQEDEIRLIAEETGFSRNQIVRLYSRFLSLDRQSRGYLDREDLLRIPELAINPLGDRIVDAFFTDKQEEIDKKINFRDFMRVLAHFRPISATQNLKINSRDEKLRLAFSIYDLDKSGYITRDEFKVILNMMVGSNITPEQLDCIAERTITEADSDNDGKISFEEFCKAMEKTDIEQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN99</accession>
    <name>A0A0N5BN99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN99"/>
    <dbReference type="STRING" id="174720.A0A0N5BN99"/>
    <dbReference type="WBParaSite" id="SPAL_0000737800.1">
        <property type="protein sequence ID" value="SPAL_0000737800.1"/>
        <property type="gene ID" value="SPAL_0000737800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000737800.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="93805" checksum="1E01696A9A5D4700" modified="2015-12-09" version="1">MKMYSNNLQSLKGLSELNNYGLIPLTTNHHNFEQKTNQINQFNNIQTFSTKNSMNMLNLLNNITLNSSNNLQKNVTSNLKNDFQISNLQVQGNTNEIDCLNFSMNNILNNTSPPKEVKIPNYTNCEWPIVNSNISVPYFNTELYNKVNFDSTWSERIDGSDLPYNDITTLRFFYNYGVNQFKGSQVNVDTGNGNNFNLPSVSKISNSRDINTTSYYSNSKLLPSSESKPTFQNYQNVDSIIGNQKILLTNQQHLSNLKNDKSNKSSSKEVTTKSLNKSTSLDDQTMPCLEPQVSIDSSSIGYAKHNAIRTSPKQSMNVYQTSQASKSTLINTNIIKSRQLASSIDESVSKTFNITLNDQITLSTFPLTNLVEEKSLKSSLICNISKNCNFIFDSKKSSCTYSKLIPVTIIEKIVCTIKSTIDKRRCTTNTITFEDSFRIIKNYKENQIKIENIEKDNKKYKIEHFTNDKYIFNHKESNTTPTTNTFNTFLQPRTSKKIKRPREITSLETDFKYDYSNDNNNSFIQNKNLEPCPLKRSKKVDVDENNDLAKCIEKLDNIKYSSDVNEEDSENFDVITSSIEPKLLQALERLTISYCNGRHYVIEKYNNTLQKAIDNIVSQELFEETPTPEELSNLSSDIENFFECSKDYKSDLYEDSKIIRYVIKTPDSNNTLNQDIENVSVEEKKKFEADVIQEALDKHLIKPVETNNSSQHKIKIKAYVAMPFFNNYLHFITNEYLKQIENDSQNSNSNSQTFNENIPSDLDKSFKLNNLSQNQIQKPTKNDLSIVPIPIRAVSLNNNFYEVSIKKIQNEKFEKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNN8</accession>
    <name>A0A0N5BNN8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNN8"/>
    <dbReference type="STRING" id="174720.A0A0N5BNN8"/>
    <dbReference type="WBParaSite" id="SPAL_0000751500.1">
        <property type="protein sequence ID" value="SPAL_0000751500.1"/>
        <property type="gene ID" value="SPAL_0000751500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF194">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000751500.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42138" checksum="9F09FE7B1886DEEE" modified="2015-12-09" version="1">MVASDENKQSIPAEATTGNVVFPPAPQCFGDAPVEWLDSMINRLQGLYNTNTMINQVISCEEVISLIYFSIKPIMADGTLIEVDGPAKIFGDIHGQYQNFHQLLDITGRIPTIKCVFLGDYVDRGPQSLEVICYLLALKCRYPDKCFMVRGNHETPSVNRIYGFYNECGMKYSIGLWWDFQSLFNRLPMAVLINKRIFCMHGGLSPELTNYDTIRTTFRPVEPPESGYLTDLIWSDPTNKGDGWYYSTRGISCAFGKGVVEAASKIMGFDLVVRAHQVVQEGYEVMMGKNLITVFSAPNYCGQFCNAAAVVCIDEKMQVSIQQLKIASTCNKTAPVCAADPNEKVVTGVLPTWNLNDAQKVVTYVQQTTTNNNSDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPL3</accession>
    <name>A0A0N5BPL3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPL3"/>
    <dbReference type="STRING" id="174720.A0A0N5BPL3"/>
    <dbReference type="WBParaSite" id="SPAL_0000783800.1">
        <property type="protein sequence ID" value="SPAL_0000783800.1"/>
        <property type="gene ID" value="SPAL_0000783800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000783800.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39470" checksum="7316FBFEB4E9ABAB" modified="2015-12-09" version="1">MVEVGGSYSTYLTKEQEDELRSICAKILAPGKGILAADESTGTIGKRLDSIKLENNVENRIRYRELLFTTPNLGENISGVILYEETYNQKASNGERFVDILKKKGVVPGIKLDLGVVPLAGTINEGTTQGLDNLAKRCAEFKKGGCDFAKWRCVLKIQSHTPSNVALLENANVLARYASICQQNGLVPIVEPEVLCDGDHDLARCQKVTEQTLAYVYKALSDHHVYLEGTLLKPNMVTPGQSYKGSCTPEEIGLATVTALRRALPSAVPGVVFLSGGQSELEASKNLNAINQCKLLKPWVLTFSFGRALQASVLKAWDGKDSNVTAAQKTLLTRAKANGDASLGKYAGESSSSAAAESLFVANHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPM3</accession>
    <name>A0A0N5BPM3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferrochelatase</fullName>
            <ecNumber evidence="8">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:22586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BPM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000784800.1">
        <property type="protein sequence ID" value="SPAL_0000784800.1"/>
        <property type="gene ID" value="SPAL_0000784800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000784800.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43235" checksum="0A94BE3D7C345739" modified="2015-12-09" version="1">MSNNNVKVQSYLIYLKSLVSNHVKLPVNINSIKRTSKTGIIIINTGTPKSYGYWDLRSYLKEFLTDQRVIEISKFIWYPILYLFILPIRPFKKRNCYKSIWNMEKDESPLLTLSRNQCNKIIENLSNKMKSPFIVDWAFRYGPHNIEERINVLVNEGCDKLVILPLFPQYSQATVGGACDEVYRTMLKLRYQPSLRIVPPYYKIEKYIEVIGNSILKKLTNDNIPLEVLIFSYHGIPLKYSQKGDPYGYQCHETTDYITNYIKNIIEKEPSKYNPLPYITTSYSSRFGPLEWLKPYTDDVVTNLGRKGCKSLGIISPSFHTDCLETWEELRDELGKLFIKLSNGGNFVFIDSLNDTKDSIDLLCQLIDSNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPM5</accession>
    <name>A0A0N5BPM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPM5"/>
    <dbReference type="WBParaSite" id="SPAL_0000785000.1">
        <property type="protein sequence ID" value="SPAL_0000785000.1"/>
        <property type="gene ID" value="SPAL_0000785000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000785000.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9100" checksum="CAB9AC4BB6172BAF" modified="2015-12-09" version="1">MSSVNRIDIYNIHIMEDETTPIATIVHSNITTLGPSGNGIIETTNLNAKMEYSVTTETIISTTSIIIYNIESVISDTINEVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPY1</accession>
    <name>A0A0N5BPY1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Toroid-shaped homodecamer, composed of two pentamers of five dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPY1"/>
    <dbReference type="STRING" id="174720.A0A0N5BPY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000795700.1">
        <property type="protein sequence ID" value="SPAL_0000795700.1"/>
        <property type="gene ID" value="SPAL_0000795700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046148">
        <property type="term" value="P:pigment biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000795700.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26080" checksum="E91DE5C8F6BDB4F8" modified="2015-12-09" version="1">MDRVESSGFISNLSSNDFDQLNINETMEKLDIKNSKGEEEMEEKKTSLDNMSDCYRSIISHIGEDVNRQGLLKTPARAAKAMLYFTKGYDENLDDIINEAVFDENHDEVVIVKDIEMFSLCEHHLVPFTGKVHIGYLPNKRVLGLSKLARIVEMFSRRLQVQERLTREIAGALMQAVQPTGVAVVVEANHMCMIMRGVQKLSSSTTTSCMLGVFRDDPKTREEFLSLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQA9</accession>
    <name>A0A0N5BQA9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQA9"/>
    <dbReference type="STRING" id="174720.A0A0N5BQA9"/>
    <dbReference type="WBParaSite" id="SPAL_0000807825.1">
        <property type="protein sequence ID" value="SPAL_0000807825.1"/>
        <property type="gene ID" value="SPAL_0000807825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000807825.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8085" checksum="12CECD7079F1A2FF" modified="2015-12-09" version="1">MRSEIKSFWSNGLRNLYCSGIKKMKALKKDANSEEYDVMEIVRDGDDKHIITFSKIEINITDQNKEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQQ1</accession>
    <name>A0A0N5BQQ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQQ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BQQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000821300.2">
        <property type="protein sequence ID" value="SPAL_0000821300.2"/>
        <property type="gene ID" value="SPAL_0000821300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025084934" description="Phosphatidylinositol-glycan biosynthesis class X protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000821300.2"/>
        </source>
    </evidence>
    <sequence length="247" mass="28827" checksum="B5D4E9F1E58D0532" modified="2015-12-09" version="1">MFINVVLLAIFVLQCDSKISCKWLEKFTEKRTLLDVTGKGMYRTMKINYNITSMERYDDCSVVYKISLPKETYIDIDKIDIIQWKHKTGHYSNIEIENPAHLGEETTFYAYPVKTFKRSFLYFDKFEIYIKLRHFPPINNSKSPSPYITFSLPQIYMSCPNVIDIMEDINCLKYLHKLPCNSSSGDRCSFIEIPIARHTFVIYGLFGNKEFSVYVGVVTAITIIMGLLYILIVSLKKDTSYDRIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS40</accession>
    <name>A0A0N5BS40_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS40"/>
    <dbReference type="STRING" id="174720.A0A0N5BS40"/>
    <dbReference type="WBParaSite" id="SPAL_0000868500.1">
        <property type="protein sequence ID" value="SPAL_0000868500.1"/>
        <property type="gene ID" value="SPAL_0000868500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="50"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="251"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000868500.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51535" checksum="A579738EAC83577F" modified="2015-12-09" version="1">MELFTSTPGNKIDVTAVDKTVPQDVKNIETPKFTDSIFKNPFFSAGLGLAGLGVLANVGRKVLILSNAYFRRRFMTSLTLNNEDLAYPWVLNYINKQSTTKTRNLTVNSNVNQSESGKTTTEFYFLPGHGIHYFKHNKRWIQVDRQREKQVISNNNRRTPLETVTLTTIGTDIGFWRRFLAEATEEALSKVETGLVVYNAVGPDWRRFGPSRRKRPLESVILEDGLSKKIHDDLEEFIKSGSWYSDRGIPYRRGYLLHGPPGSGKSSFISALAGHFGYSICMLSLSERTLDDDRLNHLLNTPPPNSIILLEDVDAAFQSREDPMQNHRAYDGMTRVTFSGLLNAIDGVACAEERILFMTTNYIDRLDPALIRPGRVDVKEYLGYCTPKMVEQLFERFYGEQATTEEKKEFVKVVSKFSGEISPAQVQGLLLMFKNKPKDAIGHLNSLLENKNNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT50</accession>
    <name>A0A0N5BT50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT50"/>
    <dbReference type="WBParaSite" id="SPAL_0000904100.1">
        <property type="protein sequence ID" value="SPAL_0000904100.1"/>
        <property type="gene ID" value="SPAL_0000904100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000904100.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="42408" checksum="2D86994DCE059151" modified="2015-12-09" version="1">MDSISGEKSTEEQNNIFALPDALLVRIFSELSWKDVLNARLVSRSFCNFIHENYHQLNRKEVYGAQVSYEKEDERHPFHLDLGFYDEEDEYLPEFPSPSYNKKIKFQTEGELSRFIKMFDIRSLAYFDVLVDDDDLDIFEIVSRFFQNGTKIHYFVACKLAEKHFNSFRTFINKLSSIKEPSIDHICSPSTEPKDILSDLSLASFDTIESFKIFECHETRILSIDMVTDLFRKNPNLTHLDIGSMNIEFLKSVFKEFFTMEQPRNMRCRSGYNPITLRLRYGGEFEHFIDTLRQNLSELENVWEQRGNPAPSRHAMFVSATDCKYCLQNKHQISRYAILWKVGLNCQEWDYRFIAHDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU82</accession>
    <name>A0A0N5BU82_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU82"/>
    <dbReference type="STRING" id="174720.A0A0N5BU82"/>
    <dbReference type="WBParaSite" id="SPAL_0000940100.1">
        <property type="protein sequence ID" value="SPAL_0000940100.1"/>
        <property type="gene ID" value="SPAL_0000940100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000940100.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38301" checksum="48B5FDC13DCA59D6" modified="2015-12-09" version="1">MSELKEKNEEISSEMSEKDINSETKNEENNKEKNSQEESKQVENDNNVEEDDSNKEDGNNKWFSNNSMWGFSMMNKALNTTMKKTMETFESVKSDFSELSKEINKQMTSTTEALSKQVENISNIIDNQLGIDEKSETEEDEEVEEKEKPEEPFSLVPPINFEWVSKITDTVKKTLTIEDTTEDEENFEKEVVLEDENKYKLDKIHFSPSLSDGKIFLQGMDNDFEKFCDTFELEDKVDEISAILSQKPDIADKYSRLVPNIMDELGFWMRYYYEIQKIKASQKNLTRNESSEDDSDVIMLPSSNETTKTKESLNNEEDETWSVCSSAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUD9</accession>
    <name>A0A0N5BUD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exported protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUD9"/>
    <dbReference type="WBParaSite" id="SPAL_0000946000.1">
        <property type="protein sequence ID" value="SPAL_0000946000.1"/>
        <property type="gene ID" value="SPAL_0000946000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894868" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000946000.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13315" checksum="88E9FED247AFA6E1" modified="2015-12-09" version="1">MFKSLLFKNLLIAALICLAVAFKLNNFSYGNDFERIKRDTNNGTLLNNRYAGYKGVLPVESQNSTNGMYDNNTVTISPDDYDNSTLNYSNDTIEIVVFEDYYDSLLSPFLGILPVGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUG9</accession>
    <name>A0A0N5BUG9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cystathionine beta-synthase</fullName>
            <ecNumber evidence="5">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUG9"/>
    <dbReference type="STRING" id="174720.A0A0N5BUG9"/>
    <dbReference type="WBParaSite" id="SPAL_0000948900.1">
        <property type="protein sequence ID" value="SPAL_0000948900.1"/>
        <property type="gene ID" value="SPAL_0000948900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="45"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="410"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000948900.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="79817" checksum="2FD950EE65DC1C6C" modified="2015-12-09" version="1">MTPVDFVNENNYDKIWTERGVQDTSGMHTFKPYVSEHKKILNNVLEAIGDTPLIKLNKIPQEYGIECNVYVKPEYLSSGGSVKDRIAIRMVELGEEEGILRPGMTLIEPSSGNTGIGLALTATVKGYKCIIVMPQKMSKEKEILIKALGAQMIRTPTEAPKDSPESYINVASRLGKEIKGGAFLNQYFNAGNPMAHFETTGSEIIESLDGKIDMVVVGAGTGGTISGIARKIKSQIPNAKIVGVDPEGSSLSNPNDKTYGYLIEGLGHEYVPKVCDIKIVDEWVRTNDKNSFLMARDLIKKEGLLCGGSSGANVWGALQAAKKLKKGQNCVVILPDGVRNYITKFCDDKWMIENNFMERNGNTSDGLSYTHSIINGIKYNPSEKPSEGWKYPPPAPLFYPRKSKLMNSILEAIGHTPLIRLNKLPKELGIEAEVLVKCEFLNITGSTKDRTALRMIEAGEENGILKPGMTIIEPTTDSIALGLALICGVKGYNCIIVTPDNISQEKEIMLQALGAKVVKTPSDVDIKSTKSHISVAIRLQHYTPDSIILDQYTNYANPQSHYTYTAEEILYACDNKLDMIVVGACSGGSLTGIGRKIKEKIPTCKIIGTDIEGSILSDPDNKDIHKYEVEDIGSNFVPAVFDRNIVDIWMKTNDKNSFETAIKLVSQEGLLCGGASGANVWAGLECAKKLKKGQRMVIVLPDPICNYLTKFVDPEWMKKRNYKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW20</accession>
    <name>A0A0N5BW20_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW20"/>
    <dbReference type="STRING" id="174720.A0A0N5BW20"/>
    <dbReference type="WBParaSite" id="SPAL_0001002500.2">
        <property type="protein sequence ID" value="SPAL_0001002500.2"/>
        <property type="gene ID" value="SPAL_0001002500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895016" evidence="3">
        <location>
            <begin position="26"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="4">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001002500.2"/>
        </source>
    </evidence>
    <sequence length="392" mass="43229" checksum="66A490697C1B36F4" modified="2015-12-09" version="1">MKSHTRIYYSIFLIFLTLFPSEVLGKRSSGGSFSRGNVPQSNSRPSGQSSNSHSNSGWNTNSGFQPAGNPRGMNNQNRNFQQPNNFNNQPNNFHQPNNFHQPNQGFGHNSGFNSHVNVPPQKSTGQWKTALAAGAAGAIGGMLLYEGTKAIIKNAAAPFNVGGKDYYWGNENYKQQNGMFMCSIPLEQLNQRTKRDAETTTTSTSTSSPSTSPATGTTPSPNNVLQNVQFANGDRPKNVVWSCRQGVEVCCGMNCCPNPQMENRSSASQGSSGPSIFSIILFILFTLLLIGCCTCALIYCFCKSLLNKCMGQDENNDQYSNQKYENNYSQEQSSYPMQNYPQGTQQQYPSYSQGTQQQYPSYPQGTQQHYPSYPSNQGGYPSNNQPVYPSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWF2</accession>
    <name>A0A0N5BWF2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWF2"/>
    <dbReference type="WBParaSite" id="SPAL_0001014900.1">
        <property type="protein sequence ID" value="SPAL_0001014900.1"/>
        <property type="gene ID" value="SPAL_0001014900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001014900.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30445" checksum="0B49569DE478402F" modified="2015-12-09" version="1">MPGNDSEAGSSDEVDSSQEHIFISGDSYLSLSDDSDLDGVVFLLTGDEGPIDSDASDSSHSDREGGSSISSIESDDDGSLSDSSDFSSDLDVGEESVIAGTSFVSEFDDDSSLYDDDSSDYPEEGEDEVVGGNIVSRVVLADGQAGGVSTSLVSEPGLLGDGRKRRSSEAENLKYKKKIRMDEKENELQARKIQIEETKEYLRGSHIECPMCLEESPKIKNPMFCAFCFKIVGCEPCCKKWVQVSKRNIVKSGSTCPLCRHNFVGSFSSNLIIVYETEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY35</accession>
    <name>A0A0N5BY35_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Histone deacetylase</fullName>
            <ecNumber evidence="2 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY35"/>
    <dbReference type="STRING" id="174720.A0A0N5BY35"/>
    <dbReference type="WBParaSite" id="SPAL_0001069600.1">
        <property type="protein sequence ID" value="SPAL_0001069600.1"/>
        <property type="gene ID" value="SPAL_0001069600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001069600.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52890" checksum="361B28A27A3D7BCE" modified="2015-12-09" version="1">MTSGQPKRVAYYYDSDVGNFYYGQGHPMKPQRVRMTHNLCLNYGLYRKMEIYRPIVATFEEMAKFHSDDYLTFLNTIRPDNMSNFEKQMSLFNVGEDCPVFDGLYEFCTISCGGSIAAAKKLTEKQCDIAINWMGGLHHAKKSEASGFCYTNDIVIGILELLNEYQRVLYVDCDLHHGDGIAEAFLTSNRVMTVSFHKYGDFFPGTGDLSDIGAGEGLNYDVNFPLRDGIDDLTYEAIFVPVMERVLQQFRPEAIVLQLGADSLTGDRLGCFNLTLKGHGKCVEFMKKQGIPLMMLGGGGYTVRNVSRCWTYETGVALDTELSNDLPYNDYFEYFGPDFKLHISPSNVPNNNTREYLQKTSLQIFENLRHVDVAPSVQFHEKPSSYLKYDESCTEDMMDTDVRLANHITDKIVEHPAELYDTEKEGERSGTDISYANIENAPVGEASKDQAMETSNESTTTTLENQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ70</accession>
    <name>A0A0N5BZ70_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ70"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ70"/>
    <dbReference type="WBParaSite" id="SPAL_0001106400.1">
        <property type="protein sequence ID" value="SPAL_0001106400.1"/>
        <property type="gene ID" value="SPAL_0001106400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000018">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="30"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001106400.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22134" checksum="7AEBE3CD02D70B86" modified="2015-12-09" version="1">MNFYFLENEKPVFTILYITIFNHSIMSNLQGKLLLQRQLQELQKNPVDGFSAGLVTDDNIYKWEVLIIGPPDTIYEGGFFKAILDFPIEYPQRPPKMKFISEMWHPNIEKNGNVCISILHEPGDDHFGYERPEERWLPVHTVETILLSVISILADPNSESPANVDAAKEFVNNYDEFKKNVSRCVRKSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZH5</accession>
    <name>A0A0N5BZH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SURF6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZH5"/>
    <dbReference type="STRING" id="174720.A0A0N5BZH5"/>
    <dbReference type="WBParaSite" id="SPAL_0001116500.1">
        <property type="protein sequence ID" value="SPAL_0001116500.1"/>
        <property type="gene ID" value="SPAL_0001116500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="99"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001116500.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37180" checksum="E6D2F6273856B190" modified="2015-12-09" version="1">MVDLIPPSIWGFDTDANKKVLLYKCNKVDANLTNKEKKNINPKDKSHYARCSNVVADRISEILSILRIKEEGKLVPKKSDKIEVPKKGEIKEDKEPIKKQKQRKKLSAKEKAKIKKEKKEKALRNEKRKGNTIEEEEPSTKKPKVEEDEDENEEVENGTKKPDIKAKLSFSKIKGVTDKGEKKLTKAEKKDTFKGRDYKALLKKAEKREQRITQIREKNPEKAEKIEENIKWKTALKRAEGEKVKDNPTLLKAASKRKEAIKEARAKKWEERKKTVEENKIKKQNRREENIKKRRQEKEDKKISKSKKKGRVILPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZQ2</accession>
    <name>A0A0N5BZQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BZQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001124300.1">
        <property type="protein sequence ID" value="SPAL_0001124300.1"/>
        <property type="gene ID" value="SPAL_0001124300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="193"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001124300.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49137" checksum="F3AE780DE926880B" modified="2015-12-09" version="1">MKICERVLSVCDGENTNIVKNDLVKEGILKKNEGGSGINSRKRLHEEQPMRVVLGDRSNKIFKLKEEQNNFLGLPEPPNYIQQEEIRNSVKRKRISSTSANSNHKKVKLDLDEDDTSEIDEKPIMMKTLKTTKDLYGCLFPNTAKPDLDEVFKEDRFHRLLEKEKDLPTSPVIEYLSPMKETELKIRRQCQCGIINIIMDRFHYRSETGLLAMAIFDDCWRQRIVNQDNSKKIAITSVYIAAKYEEVRPLCIDDLNRYVSPVFSKDDIVRTEVTILNAIDFNVVRPLSIEICRCFAFGLTYPEKGNFILDYICFVVAADYRTAHIRPSTIASCAIIIASEIFNIALGNKCLSLIKKITKDDFSKILPEICKVVIDTLSAFTNSETNRKSNEINSTFDKKKYDKSTRYFYTKLPQLIGFYEDIIGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1E0</accession>
    <name>A0A0N5C1E0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1E0"/>
    <dbReference type="WBParaSite" id="SPAL_0001181500.1">
        <property type="protein sequence ID" value="SPAL_0001181500.1"/>
        <property type="gene ID" value="SPAL_0001181500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF67">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895295" description="Phosphate transporter" evidence="9">
        <location>
            <begin position="19"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001181500.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="53166" checksum="07084A4F2F4BEC2F" modified="2015-12-09" version="1">MIGKSTFILLLGITISLALDIPSGSTSFPLWALIVGGVFAFTLGMGMGANDVSNAFGTSVGSKVLTLKKAYILAIIFESLGSILVGYNVTDTVRKSVVDINLYSGYEKDLFFGQIGTLGGCTVWLFVATALNLPVSTTHSLIGATVGMSLVMKGFDGIQWKTIGNIALSWVLSPLLSGIISAALYIIVDHLVLRTDDPFRSGLTFLPVFYFFCLAFNSFAVIFQGSKILHLSSLPIYIAIPVALGIGLIAALAVQYILKPRILRWINDTQETKVEINLQKSSIQIVVKDDNQAITSQPENTTKKDDDETSFLKWLLPTRDRKINEKTLKLFTTIQTFTACFAGFAHGANDVSNAIGPFSAMIGIYNDGNVFQRNEVPLIVLVFGVFAICVGLVLLGHRVIKTVGQKMSEINPCSGFTIEFGAAVTSLLASKAGLPISTTHCLVGSVVAVGIVRSRQGVDWRIFRNIALSWVVTLPAAGIASAVIVMIIRFFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1T4</accession>
    <name>A0A0N5C1T4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Damage-specific DNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1T4"/>
    <dbReference type="STRING" id="174720.A0A0N5C1T4"/>
    <dbReference type="WBParaSite" id="SPAL_0001195400.1">
        <property type="protein sequence ID" value="SPAL_0001195400.1"/>
        <property type="gene ID" value="SPAL_0001195400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="428"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="803"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001195400.1"/>
        </source>
    </evidence>
    <sequence length="1146" mass="131296" checksum="866CB012E9DF2233" modified="2015-12-09" version="1">MFAEGRFLDEKQFLISTPIPSSLIIGSEYCNFTSPTSKNLVLAFSDRIEIYEWRGNTLTKELRFLPGCNLAYIKCIRNKKNESDLIFVINSEFEFSIFGYNNGEIYFAMKGNIISNYKRIREQGIQIAVCPKQGKIAITGMDQNLYVIDRFERTDRKNAEFIKGPLDVVDMSFIDYSKFKSETRIAMLVHYDSYLHYEVYELDYRTCSLRNVLSIKDIPIHCTKLYCPQIYNDGTTFILGGICIYIVRGGNFSEKKLTVNNLERIELDTVIDNSIISIAPFNENPSKFAFCDRAGVLFTADILANDILVERIGNINPTASLNHLENNIFFASSMIKDSILFSVESNIENPQQTNINILDSIPYYGPITDMYMVNEDDQVIGICGGDGKNGFLTLVKHSPTFRCAWEFVAVGLHRFYVVPKDSQYNICFASTLNKTITFVLSTKTGERIEMTFPGFNYESRTLFVNYHPPSETFFQVTDEGVSITNFNDRIGNNCQLLNDDDLIVVSTNNDGVFVVANGNTIYIYNLNNEKNPVVGEYRFDRKITSIDLLKARGFNALAYFVVIFEFIPNIHVFKINIDDGIKVEHVAESTIENIGIVNDIKWYCGSDEEDSDCIVVCDFSGKAYFIDFNVESGFKSNYVVVSVGDGALETFECSVKGQRSIFFSCENAGFSPWRRWNSDVPKLNINTSLQAYSYYDNDISYIIHMEHNTAKVSYLTDEKEISYDKLEIDYDLTRFAYDSKNNVLLAVAVKESQADYYEASMHDFDLLKPDYGPRIHFPFYELSLDDVKKEIAEEIKYCASENSYIILVSLDHMKVEAMYRLPPFEIALCIKPIKIPSHLGSFFVVGTAVEKPDLSQPEITDGRLLLIEVKGDYQKTIEIRAEKSVKSPVFAISTSDDKVIATMLNSVRMFKCTIDDFKLKHSKYEFLRANRIEMYGEKAIVGDAMRSVSILTTKKDNVDVYSRLTDSRGLTAVHIFDDECYIRCVENCIHILTECQTEEFRSLQISKMLYIGVQVNKIIHGHIGKVDLSKYAGLGKCLTMATLEGSLMTLFEIDPKMYDFLKIIEGKIYDRLPRFFESHEPSEILRIKGKNQFVNTDYFKYFMTLPFETRKDILRLEGIPPYPCTNEVFDRYETLENILSLWSQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C207</accession>
    <name>A0A0N5C207_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C207"/>
    <dbReference type="WBParaSite" id="SPAL_0001202600.1">
        <property type="protein sequence ID" value="SPAL_0001202600.1"/>
        <property type="gene ID" value="SPAL_0001202600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001202600.1"/>
        </source>
    </evidence>
    <sequence length="53" mass="6241" checksum="593CE4C2BCA25C4F" modified="2015-12-09" version="1">MYANYLRVLGSGLEEKDFYRVILDNVPENFRAEIVRDAMEKPDGLMMDPEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2K9</accession>
    <name>A0A0N5C2K9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2K9"/>
    <dbReference type="STRING" id="174720.A0A0N5C2K9"/>
    <dbReference type="WBParaSite" id="SPAL_0001221900.1">
        <property type="protein sequence ID" value="SPAL_0001221900.1"/>
        <property type="gene ID" value="SPAL_0001221900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="355"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001221900.1"/>
        </source>
    </evidence>
    <sequence length="1123" mass="132357" checksum="87FE086756DB7082" modified="2015-12-09" version="1">MKNTTPEDQIKRSRMESMNKNGEVISDVKKKPILSYAEVAKKRENIKHRDSKEDSQEMRKSIKEMNPKERYDYFSKDRGKIFRFDVKPWMPTFEIDLLIEKKLRPLTQVWSKTKITDIESKKTWRQASKIMIIATKVLKSYDTRKVDYDGTSVEDVIKVSAALRRTERFDQRIQKMLEQTKSPQKNIKNHAQAYLRKVEKKFKGKVKTIEQVRFFTKSKISTLKKRVAYLNEKKRRDRIRMRFRSKPSLKSLVDTTPLDIEIDKSEIEKYLIDLFSKKDCEVPEPESLLNKWVEYSKNTTSIDEDSKPNFNEEIFNECLKWSRSWKAPGTNKLYMKIFKVLNSCKIFLMEWIKAVYERRCNLTDEDTRGRAFGIFKKGNIDDPKNYRFINVTNSHYKIFMKYLNSVIVDQIEHRIPKEQIANKKGRSCLDGIIINRLIQKKTVHGQQIAQTWLDMQKAYDSLDHKKLLIVLENLGIHRDFIEIIKKAMRCWKFTVINGKETYMNNEKKKKKPTVIHVNRGIYQGDSLSPTLFVCSLIPLSWMLNQQPRINLEDPNTEANVVTTMNDDEVEDEGLYNHLLFMDDIKLFSINAKCLNEMTKICEKYGLEIGLKINPLKSSYSINQGEQAEEPLINFEELSTVYKYLGIYENHKTADEKANLQELYKVVDEKLKLILESPITVGNMIDAINTCLMPKILYVFSHERSELIKRKIYLDMDLRIRKALNTYGVKFQNLSNARIYLPRSRFGLGLKSTETEIDKIQLKNFIHIKYSEVFRKMNETFKMMENDIITIASKYNINMSFEEGIPCINGTIGSEKEAKKKISELVDNFAYKRWAEHYTRKKEFPKFVINNKLICPWLRTLNIEPRKFKTITMTQDDMHPMLNPIFDKESKCVLETNSVKCNHYDNIRHVGSYCEHSVSWRRRRHDNVLHTITNVLLRKLKQKMVDLNNYKKCYKIDDNTELRIDQLNYTSESLVHNKPDIIYETKDKIIIGELAISHYRNLEESAKLKIQRYTVNGTLQLNAPVENLEYSTNFTAVLAKQKGKPVSFYPLICGPFGELDGPRLDHWVAFLDEFNISEKETIKPVIERITRKAAIETEYILFQYIKLKEKKLKENNDEQNDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2T9</accession>
    <name>A0A0N5C2T9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2T9"/>
    <dbReference type="WBParaSite" id="SPAL_0001229600.1">
        <property type="protein sequence ID" value="SPAL_0001229600.1"/>
        <property type="gene ID" value="SPAL_0001229600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229600.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14167" checksum="A18F8A3A55DBC7AB" modified="2015-12-09" version="1">MSQENKEQRWGKVDAIINEMKETCKRKITNNNEEESCISRKCLKLVGNVGLREPLCIINTRITDEGINEYLVRWKGYSISYDSWENATKLPKEVIDAYLKTQELLAFMKEEKMDYKFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2V6</accession>
    <name>A0A0N5C2V6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2V6"/>
    <dbReference type="WBParaSite" id="SPAL_0001231300.1">
        <property type="protein sequence ID" value="SPAL_0001231300.1"/>
        <property type="gene ID" value="SPAL_0001231300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001231300.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18835" checksum="61F394D2E3346253" modified="2015-12-09" version="1">MKHKELHLSYCFDNNQVENNYHFILEDDNEEGGSVFEPTVVFNETLKKEECLKTIKEEKRSGYKILKIDVVSHLIDKNETDLTYLQFDLQWEDSKENERICTAFIGFASNMTRQCAIVECEWYDEETTTIKPTVKPSGRYLVISKMSKQIVEQISKFVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C375</accession>
    <name>A0A0N5C375_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C375"/>
    <dbReference type="WBParaSite" id="SPAL_0001243000.1">
        <property type="protein sequence ID" value="SPAL_0001243000.1"/>
        <property type="gene ID" value="SPAL_0001243000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001243000.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15600" checksum="3A89DCE328AFA3B0" modified="2015-12-09" version="1">MSKDSSFYCFICDKRITTNENKFYHFEEHVDYKPFRCLDCNGRFKQEAGLEEHLISSKHLNYSRTVSLDLQKFITFMEVYSSQVENLTEEDISNRIFILPQKNDENKAKKEVKKYTEQNGNSNFKTSKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3H9</accession>
    <name>A0A0N5C3H9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3H9"/>
    <dbReference type="WBParaSite" id="SPAL_0001252500.1">
        <property type="protein sequence ID" value="SPAL_0001252500.1"/>
        <property type="gene ID" value="SPAL_0001252500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001252500.1"/>
        </source>
    </evidence>
    <sequence length="19" mass="2034" checksum="1F5277F2A83D8E8E" modified="2015-12-09" version="1">YKAFAHLITTGAQDELANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3I7</accession>
    <name>A0A0N5C3I7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3I7"/>
    <dbReference type="WBParaSite" id="SPAL_0001253200.1">
        <property type="protein sequence ID" value="SPAL_0001253200.1"/>
        <property type="gene ID" value="SPAL_0001253200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001253200.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12901" checksum="456059C51B731C45" modified="2015-12-09" version="1">MKVAPTISGNLERLTEDRVNLDEYLKELLNKPLIFTIKVSKFISPSQPDKPSSNKLIDYINFCPAQVYFSWCQELMNPERIVSSMSPILITCSPVIGIINYHSFYIVITPVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Z5</accession>
    <name>A0A0N5C3Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus membrane</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C3Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0001267800.1">
        <property type="protein sequence ID" value="SPAL_0001267800.1"/>
        <property type="gene ID" value="SPAL_0001267800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21192">
        <property type="entry name" value="CH_SYNE-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000099">
        <property type="entry name" value="Nuclear anchorage protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058344">
        <property type="entry name" value="DUF8031"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057134">
        <property type="entry name" value="Spectrin_Anc-1_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524:SF5">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26081">
        <property type="entry name" value="DUF8031"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24611">
        <property type="entry name" value="Spectrin_Anc-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="191"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1955"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3453"/>
            <end position="3476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1827"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2195"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2357"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2432"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2936"/>
            <end position="2966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3127"/>
            <end position="3161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3243"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3366"/>
            <end position="3445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3543"/>
            <end position="3610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3708"/>
            <end position="3762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3968"/>
            <end position="3999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="4237"/>
            <end position="4281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="4375"/>
            <end position="4426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1965"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3460"/>
            <end position="3469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060457"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001267800.1"/>
        </source>
    </evidence>
    <sequence length="4522" mass="523350" checksum="6E720E8C2C397F10" modified="2015-12-09" version="1">[encoded data, 4522 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C489</accession>
    <name>A0A0N5C489_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C489"/>
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        <property type="gene ID" value="SPAL_0001277100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001277100.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24277" checksum="8919512A5360BC80" modified="2015-12-09" version="1">MNTMKERRRSKEISSKKMAFVEGNLKESREKNKFYPIEEDDYEDMAIGDSRIYHKSSKNFKNNHDIVPIDVINGLEIIEEVDEKEDNSEEVSNGDSDCDIVELYHSCEKKSTDHRYTNGNRFIIACVDGEPFTRRTYDCDEDPHTNDKINLIKNNENNSENDNSHIFYGVQYNNETFLQISSEEPLQDKSSKVISKKKNDQRKGFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4K9</accession>
    <name>A0A0N5C4K9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORFan</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="SPAL_0001289000"/>
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    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="36"/>
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            <begin position="140"/>
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    </feature>
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            <begin position="273"/>
            <end position="305"/>
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            <begin position="86"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
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            <dbReference type="WBParaSite" id="SPAL_0001289000.1"/>
        </source>
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    <sequence length="379" mass="41368" checksum="2EA96EC9695FCEF2" modified="2015-12-09" version="1">MGNIITTVCIVTSLIVIIIIIGLIVYYYYYKNPKNKKDGKEKSKSKASSSRSTKTRTKSPSSRRKVRSTSTASKKGTTSSRRRSSSRSGSTKSTLSKTDGSQSILKTNSATNVIKTLVNKVYPGEIQVEIPSKDKLKFSEADSKKLRSPKTSNKEKKKVSSDTPIPLVTDATVPNDKTNIESVNTTSAVKNGFDGNVPKVVEAKQPASVAFEDIPSGKSISNDLLKYKTNTHYIPPTSVAIPKEVSISSDVNPPTSNDLLKYKTNTHYIPPTSVAIPKEVSTPSDVNPPTSNDDSKTKSVPMNSTDVKPFTGSLLTTNNITFNNVNIHVHNPEESNVKDHVQENRITISEPDSETPNLPPLPSSTTTKIEEIDDDWVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5F6</accession>
    <name>A0A0N5C5F6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="174720.A0A0N5C5F6"/>
    <dbReference type="WBParaSite" id="SPAL_0001318400.1">
        <property type="protein sequence ID" value="SPAL_0001318400.1"/>
        <property type="gene ID" value="SPAL_0001318400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001318400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36669" checksum="D7BE94F9A5A489C7" modified="2015-12-09" version="1">MSNAKAKEVIQKWVKNVLDKGVPALRKDFNDNKRYFPKDISLNAFKEAHPLKKNRYKDVPMQDKNRIVLNFPGGTGDYIHANYVSTPNSEKRFICTQGPLENTVVDFYRMIMQEEIECIIMLCNLVEKGQPKCFLYWPDKKDETKKFDDFEITCIDKSELEKAYPNIIKSTIKIKSNYEGKKCEQIVKHIYWSDWPDRGVPVNTDSATTLLNYVRGTTKPILVHCSAGIGRTGSIVAIEYILEKFVNGESPESPIEIFKIIRDQRPYSIQTELQFLFVQKVILDLIVGNNKKKMDSKMLALLEKFEKDYEEACNQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C678</accession>
    <name>A0A0N5C678_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">FA_desaturase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C678"/>
    <dbReference type="STRING" id="174720.A0A0N5C678"/>
    <dbReference type="WBParaSite" id="SPAL_0001345200.1">
        <property type="protein sequence ID" value="SPAL_0001345200.1"/>
        <property type="gene ID" value="SPAL_0001345200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001345200.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38856" checksum="F7496D483F639E41" modified="2015-12-09" version="1">MTTVTKTVELSQAIKEQYLAQDFDEVRKLNDESKLKTFNRRIVWRNVLLFGLLHAAAVLGTYHLLFCVKWYTFIWTFSCWVISGLGITAGAHRLWSHRCYKAKLPLRIFLMLCNSMAVQNDIIEWSRDHRCHHKWTDTDADPHNVNRGFFFSHMGWLLEKKHPKVKEMGTKLDLSDLFNDPVCAFQRKYYLPLSIFSCFIFPTWVAVAGWGESAFYAFYTAGVFRYVWTLHATWLINSAAHTFGYKPYDATISPVESVWTDVLAIGEGGHNFHHTFPQDYRTSEYGYELNLTKLFIDAMQMIGQAYDCKTVAEEVIARQCASKGEGPRPVVSKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6K7</accession>
    <name>A0A0N5C6K7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6K7"/>
    <dbReference type="WBParaSite" id="SPAL_0001357300.1">
        <property type="protein sequence ID" value="SPAL_0001357300.1"/>
        <property type="gene ID" value="SPAL_0001357300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7381" evidence="3">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="205"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001357300.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37886" checksum="D8C4CC0876FB77E1" modified="2015-12-09" version="1">MLVAYYTISIIIFILIASTTQLIVIPYLIRLKNKNKLVEYKGYVYKSLSDLVKRILKEQFPETIEGICIYNAGLKKGEQIYKIFSFTCESILKYRYPHYGSIEYEVMYPNSVRQNAYYCGKDVAYNFPTIIDYALKNHCYIQFRPRHFRPTPPPLQFCVSTLHGRLCLERTSTASQYWQNLWSDCDRKCFYGNNFVRPRLKYLLELNYYRKGLWKKPLFLSEKLSLSATARAEKMVKSKRILPNSKKDETELAFYAPGVYGIYIPRIILENLFEKNSISKKESSHKKTFSILFDGNHRYIGMGFAKRGNGAYICIKLSKSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6R6</accession>
    <name>A0A0N5C6R6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6R6"/>
    <dbReference type="STRING" id="174720.A0A0N5C6R6"/>
    <dbReference type="WBParaSite" id="SPAL_0001363100.1">
        <property type="protein sequence ID" value="SPAL_0001363100.1"/>
        <property type="gene ID" value="SPAL_0001363100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF210">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-13 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001363100.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43930" checksum="89973469E45D4BD9" modified="2015-12-09" version="1">MGNLCGIYKSNKTSPEQAPIETNIKTTNGKSDNNEKVDEGDRNENNEIEVKGILKNKIKNDEDNDETLRILLLGAPESGKTTLMEQIRLLYKQDFKDTEFLHRKAFIYNNILDSMRQILSYMKKKNFCLENKDNETKADFVMDGFENLYGPFNEKESDAIKSLWNDKNLQEVYKRRAQFNLNDSAGYFFEELDRINQQNFVPVPEDLIRAYVPTLGVDNLIFTVKNRSYQIIEYGGTKLDVKLLEDLYDGINCVFFVVAISEYDQFLPNDEENSKLQNSLKILDKCCNYCRDLNVPLYVFLNETDVFIEKLDVSPLSVYFDDYAGLSSKDALLFMHELIEERCSMHGLKDLHHEILCCCIKIDETGKMLEKIFKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6T2</accession>
    <name>A0A0N5C6T2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Product</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001364700.1">
        <property type="protein sequence ID" value="SPAL_0001364700.1"/>
        <property type="gene ID" value="SPAL_0001364700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001364700.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43803" checksum="D2653EC572164298" modified="2015-12-09" version="1">XTSSAQQTTTLGLYSEFKREYETLLDGSRVLAEVSSNDTDKVVVKLSANEVNPPRLRKTEKKQPSPIPKERRTEMSEIDSYTLKKPSIDDKKNISKKYNRMTLAQQLEKSFRENNINLNNTEVKNLGDPLNHTYRHNLEETLTNFDIKCLANSTTKEESIVRTLFTDDKSQKFSTPYLSRTFVKNLGLNRVAMNGEINEALLRKQKFSLVNACSTEIVRQSSNPKIGNDVNTPTTISDIRLKNSESTNDNNIITTTNTQDIYSIDDNNVSETTKSNTTIETIIKEPIKKLDESINIITKTTDRTDIVLEDTQQVENKQYINPILIEDFREEMNQNVKDVCDFLSQKVRNESAVNLVEERFVENIRFLYRFFFHSCREKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9P0</accession>
    <name>A0A0N5C9P0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001461900.1">
        <property type="protein sequence ID" value="SPAL_0001461900.1"/>
        <property type="gene ID" value="SPAL_0001461900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001461900.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19486" checksum="188688A11FD7C714" modified="2015-12-09" version="1">XIFSLNDLKKLYYMYCNGTCKALSNQCLNGGYPGIFCHHCECTIPFMDWNCGGIRRNWNPSCGSEQRFFSNSNEANVKRENIDNVCYYKITSSKNKKVAVTIKHVKFSNSSICSDDKKGLFIHYRSDKGLAPLHICDNATNVKIPPSSSTVYISFRVNNGNNVLHFSYKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA62</accession>
    <name>A0A0N5CA62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA62"/>
    <dbReference type="WBParaSite" id="SPAL_0001478600.1">
        <property type="protein sequence ID" value="SPAL_0001478600.1"/>
        <property type="gene ID" value="SPAL_0001478600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895649" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001478600.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8959" checksum="8956FDDA5DB4C8A8" modified="2015-12-09" version="1">MFFKVYLTIIAIVLVTFSLNCSAQLDDSSSDVFYSAEEGTIPKATNIPKILESSDSENDEWYSAEAFEKRSPTGEEIVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB95</accession>
    <name>A0A0N5CB95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FCP1 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB95"/>
    <dbReference type="STRING" id="174720.A0A0N5CB95"/>
    <dbReference type="WBParaSite" id="SPAL_0001515800.1">
        <property type="protein sequence ID" value="SPAL_0001515800.1"/>
        <property type="gene ID" value="SPAL_0001515800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="5">
        <location>
            <begin position="152"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001515800.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39028" checksum="E9C67645A7CCEFBE" modified="2015-12-09" version="1">MEISTIENVNNLNNNKKINNNTNINEIFLESSPILHELHNIHEDSGIVNDDVNNQLIWSVCSSQPMTTDLQIMEFEDTLNEVYRGKCEMDDEVLNIEDFEDLMDDNSGGKIISCPSEHFEMLDETAIKLLQNPPPLTKEWQFRSPALPIQTRSTPKYTLVLDLDETLVHCSLIPLSEAALTFSIEIDGLTYKVYVRIRPYFKEFLERLSQTFEIILFTASKKIYADALCDILDPEKKYIRHRLFREHCVYTENVYIKDLNILGRDLSRTVIVDNSLLSFAYQIDNGIPIKSWYEQKNDCELLNLIPFLEEIIQRDADVRPMIREKFRIYDYLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCE0</accession>
    <name>A0A0N5CCE0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCE0"/>
    <dbReference type="WBParaSite" id="SPAL_0001555000.1">
        <property type="protein sequence ID" value="SPAL_0001555000.1"/>
        <property type="gene ID" value="SPAL_0001555000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="91"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="130"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001555000.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50557" checksum="45D46A3900A2FC62" modified="2015-12-09" version="1">MLKNEETNLEATRDATEILEEIAERVLSKDTRKNNKKRRNKFRKRSKLFEGDIVLTPRQAEKVIMDVAERATNAGIDISDVVNETQIRTKRKIDNTTILQWKFPILYYVDPKVNASKIDIALRSIESETCIRFKKVDREMQDQPGLLYYDDGDCYSSIGRLYEQQFQPISISGICDTIGTIIHETMHALGSHHEQSRADRNDYLTIFMSNVEEGFENNFFKTDFSETISYGIPYDYGSDMHYRTNAFSKNGEPTMLPTDPLYKKTIGMDAGLTFLDAKILNEHHCQHKCIRPIKCYNGGYRNPNDCFSCKCIAGFEGSDCSKMPDDSMECGDAVRKVSKNKTVRLYSRGKGNCIYHIKSETNSTLKITLTEIVYFPGFKSTCVLENSLEIKYYNDKSLTGALFCLSEKNRTIVSQGDHVIVHHRSTQGTNFMLMQFENVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCF2</accession>
    <name>A0A0N5CCF2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF695 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCF2"/>
    <dbReference type="WBParaSite" id="SPAL_0001556200.1">
        <property type="protein sequence ID" value="SPAL_0001556200.1"/>
        <property type="gene ID" value="SPAL_0001556200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001556200.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19420" checksum="039775E88881F975" modified="2015-12-09" version="1">MTVTNIWFKTIGDKTVNEWILTMDTFIDNPTPRSEDQFIELIKDNILELMDEEETAYYICHLFWDCFNNPYKLLCIIKSAPGYDFNIFLRNQYCSEIFEIIWMKKDGPPIEYVYLFDEIDWFFENIDIEPVKKEFEFICAVTKFSKLNITITEWKNKYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCI9</accession>
    <name>A0A0N5CCI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid sensing ion channel subunit family member 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCI9"/>
    <dbReference type="STRING" id="174720.A0A0N5CCI9"/>
    <dbReference type="WBParaSite" id="SPAL_0001559600.1">
        <property type="protein sequence ID" value="SPAL_0001559600.1"/>
        <property type="gene ID" value="SPAL_0001559600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF244">
        <property type="entry name" value="DEGENERIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001559600.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49943" checksum="9B14071565B97521" modified="2015-12-09" version="1">MMTLTIIIVMQKIFGRKIETKVLTTRRVNEDFFPKISVCFNIHNKYDEDSIFDSDPEFKNEFYGKKFSTDMKTNSFHDPEMYVNNLQRNYQIHVKKLIKDQDILTNVSVLECTYLGQNCNKAMFNNSYDDYGIGRCFSFIKKKLHFGAFSRVGKEFGLSVLLKNEISDIKNHFRKAYGYPPYLSIQYQIFNDRDNHQLSTFHTNILPLGYEVNIPITITKEIKNKNTSNCLYYNTGDPNSLHTSGAYTYDSCYTSCLKKNQLAQCQSVMPFEPNMCSKEKPCTCNDLNCFNCLSDSLFPDNLNNGILHPEFKDKCSCPPPCETYTYITNPTYSKLHAKNMAAMLGITGSEEDLEDDISANYVILNFFIKEHTVLTKKEEIVYRSANLFADIGNSLSLLLGLGMINIIEIFFCLFLIIIDRIRYFIKFRHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD21</accession>
    <name>A0A0N5CD21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD21"/>
    <dbReference type="STRING" id="174720.A0A0N5CD21"/>
    <dbReference type="WBParaSite" id="SPAL_0001576800.1">
        <property type="protein sequence ID" value="SPAL_0001576800.1"/>
        <property type="gene ID" value="SPAL_0001576800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF86">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="99"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001576800.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47834" checksum="5CC4FA17F8195B7B" modified="2015-12-09" version="1">MPPNQEGNSPKINMSTSKRILPVPFDEDTLKHGKLLTEKFSDFLPEDIRTDFHMARWVRMYKGNEEIIESKLKEYIRHRKSFDYEGNKIIKQCQKLEFAQTVWDKFSISKLDQTDYSGDVAVFLQRMEGTDLKEIIKTVPYYHILHSYFLLQECMQRAILLKEKETGRQSAAIIILDLHGINLGDFVNPLSNPTKLARIVVKIWSDYFTENMVKLILVRPPGILSIMWQLAKYILDEKTAGQIEFVQKYEELKDYVDESVIPKLFGGTRIDNTGWSETPESCVKAPRKVTQDLYYNSEKIFKTHGFEKIPPLKSISIKNKHTESVIVKGKVGQKIIWHYMTSNELIFDVLIKEDGTSHLNEDIPIIPGVYGTCLKLPEQGVIDVVKDGEYHFRWTNPHKGWLAAKVQYAILCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD72</accession>
    <name>A0A0N5CD72_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD72"/>
    <dbReference type="STRING" id="174720.A0A0N5CD72"/>
    <dbReference type="WBParaSite" id="SPAL_0001581800.1">
        <property type="protein sequence ID" value="SPAL_0001581800.1"/>
        <property type="gene ID" value="SPAL_0001581800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001581800.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58157" checksum="39B9E5925A707DFF" modified="2015-12-09" version="1">MHTRKGKHRFFKKIFKGSIKESRNIGTSTSNSNGSLDSKDDKQNKTKKIVSVQSQVTVFNNSKNDKPGHKTISINVNESMDKLNDNVGKGNKTSKLRESKMASINKTFKTENIDDFNMDPEVIKNTIKQLIKYQWYHGLLPRDEVEEFLVSEGDYLVRKSEVNSSTRFVLSVKGKDMHINHVVLNWSEGSWYMLKGEVSCPQLDELLKTYITNETPIGNNKVILRRPIPKPHYYIDHDHIKILKEIGHGAFGVVCVGTYTINDVVRKCAIKSLKIGKKIDKIQRKEFVKEAKINLKLKHKNIVNLYGFAINEEPLMIVLEYCENGALNSYLKKHPETSNNVCMKFVVDACRGMCYLASKNIIHRDLAARNCLIDENLTVKISDFGLSVANVVSITLNAKTKVPIKWLSPETIKEKHFNLATDVWSFGVVIWEIFSRCQSEPYPRQSNKEAKEIIISGRKPMNAPPNTPPVFANAMDKCFTQNPKLRPTFGVLLKFLAPSETPPDELVFCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE43</accession>
    <name>A0A0N5CE43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycylpeptide N-tetradecanoyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE43"/>
    <dbReference type="WBParaSite" id="SPAL_0001613300.1">
        <property type="protein sequence ID" value="SPAL_0001613300.1"/>
        <property type="gene ID" value="SPAL_0001613300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001613300.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23607" checksum="CD3D0CCF6153887A" modified="2015-12-09" version="1">MCEKTKIHLGLNDLWRKYPNIFQYNTNNARRLIVGKLIENYVEDEKVCPHHVLHLLFQDKEMVNLIKNKKYTFKLLCKSSNYGQFIYLTLLVIIKKGKKFRGGLGDIITNMLKPPFYLKTNEEVSKFIENVLIYVCIRRSRLRRIDNCNIVLNFLEFNRIHTNLIFDAVEKEHEKDYRPHIRPIKDYELRNYEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEQ6</accession>
    <name>A0A0N5CEQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEQ6"/>
    <dbReference type="STRING" id="174720.A0A0N5CEQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001634300.1">
        <property type="protein sequence ID" value="SPAL_0001634300.1"/>
        <property type="gene ID" value="SPAL_0001634300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="352"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001634300.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="51698" checksum="87032F8F58754966" modified="2015-12-09" version="1">MSIAVTTTVSAALPQNSNNNSSPSTLNSRSPGNGVTTPVVPPVVVPSSTYSSYPGIDMGYQGGSLPDPSHYYWGNQHPIPGVYPPVHNGYPNPMLNMNGMNNDGYSRTNVSTSLPQVSSPAYPQSIQPPTTASTETEVVEIGKIYENSTENSNSYQTLSANHYQTSSSTSGQIPAPTPTYNHYHIPTTSDKPTINNLLELSSCHSQSLQSPVYSFPQSNIENISGVPQKPEPLTSIHNQLNNPHNFYQPHHPSLHNLQTSDLLSSQIPGDIYNIPPVNQSQSLHHQELLSNGYPPIPSSDYTNSLSSIHGINLSPNNHSVSGRNSSKSNRRMKSEIKDSDDDGKSSDDKELDRRSANNARERIRVRDINSAFKELGRMCAQHLNQANDKAQTKLNVLHQAVSVITQLEEQVRSRNLNPKAAAIMKKREEEQKIINTMSGIQNIAPQNAFAPHQVNGSDGDAKPPLQSNVSVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEV0</accession>
    <name>A0A0N5CEV0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEV0"/>
    <dbReference type="STRING" id="174720.A0A0N5CEV0"/>
    <dbReference type="WBParaSite" id="SPAL_0001638700.1">
        <property type="protein sequence ID" value="SPAL_0001638700.1"/>
        <property type="gene ID" value="SPAL_0001638700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057775">
        <property type="entry name" value="USP48_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24543">
        <property type="entry name" value="Usp-48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="105"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001638700.1"/>
        </source>
    </evidence>
    <sequence length="1063" mass="123418" checksum="486E5289B1305A9C" modified="2015-12-09" version="1">MMKNKVKRKFNLISKPPDKRDILTRELIHNSNISIVDRDSLFNLINLNSTFCEHDSNPNKKSNCKKYCRCLEGLGNDVWKKTYEKVVDEEEGNNINLRAIQEKPCGLNNTGNHCYVNSFIQIWFSYIPFREAVYTFEPINDFFPKDTKINIQDIILTLKKLFITMQITPFEEACALPLITLLKLDNEQNDALEFTTLFFATLERELGNHPNGEKLRNLLQTCLSWQQEQKLVCSCGYKSETSMEISSLHLHIEDVKALPMAISNYFRVERLEDFKCSGCLKSGFVEKRIKITKFPPVLLIQLNRVSYDYLGRNVKVKTPIEYPRLLRSSMISEGLNEDIEYELFAVMIHEGKETHCGHYYDLIKDPGSGKWFRYNDRIVEEVKAPGYDDEPTGKVKCDMKGCYALLYKIKSDDEPIPQPDDDLRDMIENELNELFKIQKEGTIWDRLWRTVYKKYYTIVSSIWNELKVSSSPIDEENMDDFVLLPTELIKEFSSCLYDSYSKRKVFPPDVILKPERDSTVEEIFEVFEKDIYQRKASSFVSIELCCHKKICLELILSGKIKVVNRKAAEDILSLLPVNVFLYKNNEDYLPYSLPSVDSICLECLKILIQKINYENSFKETERILKKVNNEYIKRIPEKILITWKDDVNNGYWVSKDELKNYRKLALLSIGEQFKVDDSTYFVGFANDVSSITNMDDSDGLCQLQDDEVLPKKGKHDSDLECFNNLQLCTQEKDKSLIFNGSLKCDHGNLSISKKRLYVTEEEWKQLVKPFMEVYTVPYQTSECRECIAIQNAEVSKRQDYVSKINSIKKTLGPILRTIENRNIMDDTASFSLGICKQFLKHLINFRNGDKADEITGICQECVLCEDHNMPYLSPEMKEYAEMLAPIDEEEWDLIQETISSVGFDINSKKIFLNHTETLSSYEFCNHCNSKALEDQENSKYFYPDGGTVVVRITRDDNCNKVEISRYGRRSNRNQLTLKMFSTETVYELKSRIATEIRCDVYALSIFNGEKELDNASTLEQSKVPQNNQDYPLQAIVYTSNGSQETVYEERPIEKGFKDTVLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG04</accession>
    <name>A0A0N5CG04_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG04"/>
    <dbReference type="STRING" id="174720.A0A0N5CG04"/>
    <dbReference type="WBParaSite" id="SPAL_0001678200.1">
        <property type="protein sequence ID" value="SPAL_0001678200.1"/>
        <property type="gene ID" value="SPAL_0001678200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF327">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001678200.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="29213" checksum="A4F6208BFED044FB" modified="2015-12-09" version="1">MEDTRERAYKAVAYSAVTLSFIAILAVGITMPIMYNFVDHIQAQSRKELEFCKVSALDIINEVSKRESKFTFESLTIANRTRRQTGGCESCCLPGHPGRPGPPGSNGKPGAPGEPGRPGPPGRPPIVCEEPEIPPCNPCPPGPPGPPGQPGNPGQPGHNGNPGRPGNNGPPGPPGPNGPPGEPGTPGRDGEKGDAGRPATSTPSIPGEPGEPGEPGPQGLPGDDGEAGRDGSPGQQGPPGPPGPIGPPGAPGVPGENGAPGEPGAPGERGICPKYCALDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHW0</accession>
    <name>A0A0N5CHW0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHW0"/>
    <dbReference type="WBParaSite" id="SPAL_0001742200.1">
        <property type="protein sequence ID" value="SPAL_0001742200.1"/>
        <property type="gene ID" value="SPAL_0001742200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001742200.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="77594" checksum="9F1EF6D2DE281E0A" modified="2015-12-09" version="1">MPIHATFADNPVINNHNIMLNSSIMVTNTKQFVEGIKKFIFIAENPNLTSNSGYGLSDLGFILLQLKESLVTIDQRCINVAPEFASKQFNGLTLLLKIVVILQGIVQNSIGQKSGSKITQLLSKKNNSTTSSIKRKASVCEADCIECIKIILEKVPPSWRIFLDNQHNLEIILHSINSPQLDSKCYSLEIILQLLDHENGFEQLFKSLTIVAARVGEYQRLILFTKQLKHGLHTNKLHIQILIAKFMNKLLLMAPSTNYKLLCQSEALIANYSPEYIRKLITTVNGPLVGLDLLNDELGIWLNLLTPIDKDPPQSTKSIDSSLYDNDYSYNMAFNSNTGKSRKNLTSLAKNVERHKYKKYNDVTPPSSNEHTINYSQNNNSLKKKHHDYDEAPLYPIQIPTTIQEKFQVPQNHRHHQSPFIMDPGKMRRVKSESAMNIEPLSEEDSDNDVNNFDLHNQNLGGLRNYKNIPSIPIKITSHSSTKNLNQYEHPSYTTPNRLGNGKVMSKSINDLSFINTSKNDHFHRHSGREGMSPKTRQSSINIVPASQMPHGGFSYLFPNAPVVDRVSSPSPLSPRPLSVIGRSGPSSPNYNNINNKNQGNVVYIPIQKQNTLERKKAGFLTKKESFKFGDSQVKGGILKTESMKKNPYSDEVKDALSQFDYLNDYEESSTITGSVGNPTKSTHTIYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI77</accession>
    <name>A0A0N5CI77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI77"/>
    <dbReference type="WBParaSite" id="SPAL_0001753600.1">
        <property type="protein sequence ID" value="SPAL_0001753600.1"/>
        <property type="gene ID" value="SPAL_0001753600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7583" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001753600.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10061" checksum="63CCB10074AC8514" modified="2015-12-09" version="1">MEPEKNVNLKTILFNDESIEADYLQNTISKSKDNFKLEEEFVYFEGNNPNGKYTCVYKLQVGEIKTFQEYQSIEGTTLPDVKYAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2J5</accession>
    <name>A0A0N5B2J5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2J5"/>
    <dbReference type="STRING" id="174720.A0A0N5B2J5"/>
    <dbReference type="WBParaSite" id="SPAL_0000030200.1">
        <property type="protein sequence ID" value="SPAL_0000030200.1"/>
        <property type="gene ID" value="SPAL_0000030200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000030200.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29751" checksum="93918AFBE8CBC4DA" modified="2015-12-09" version="1">MKLIFFAITFSFLHNTHEFFLRNDRYKRQAITGWDNNAEPGYLPDYRGDKYTDPQRIKDTQALNKPFFDSIGGEPVYPGGVPPKEGTSSSATGTNTYYQNQQYPSSSSSSSSSSNSGMSSSYSSSQNQINSQNLYSDETPESFTSEYPTQIQRDYFVPNTYETSTTNYGLLNNGYVSSTTGTSGQVLPGSYSTIGTSNQVSSGSYSTSGPIWQSANPGFLPDYRGDKYTDPQRILDTQNLNKAFFESIGGEPVYPGGVPPKQNIVTSSPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2M6</accession>
    <name>A0A0N5B2M6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2M6"/>
    <dbReference type="WBParaSite" id="SPAL_0000033200.1">
        <property type="protein sequence ID" value="SPAL_0000033200.1"/>
        <property type="gene ID" value="SPAL_0000033200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893622" evidence="1">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000033200.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26591" checksum="4F41CCE4E7F64B6B" modified="2015-12-09" version="1">MYSIFVILTLIKLVLSIERTMFDFGSITPSRLTPFDIEAYTKAAVIRQNQENAFIAHMSTLAAARRASIARDQIKNGTKQGVNYPKEDVNGIPELLQKFLIQREKDHLAQIQSIMLQGQRRGILGENERLVGNERSDQMIERFLNQNNRGSNVYQPDGLNSGTFNPFPVFNRGFPRERAPITVTSTIIDSPTKEETHLRRLSIPKTVTEKSSNDTIPLPTLDQLPVPVEDDRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B394</accession>
    <name>A0A0N5B394_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B394"/>
    <dbReference type="WBParaSite" id="SPAL_0000054600.1">
        <property type="protein sequence ID" value="SPAL_0000054600.1"/>
        <property type="gene ID" value="SPAL_0000054600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000054600.1"/>
        </source>
    </evidence>
    <sequence length="21" mass="2626" checksum="918CCCFCF779EBBF" modified="2015-12-09" version="1">MHSLHQFFFEKDTSKIFIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3E2</accession>
    <name>A0A0N5B3E2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3E2"/>
    <dbReference type="STRING" id="174720.A0A0N5B3E2"/>
    <dbReference type="WBParaSite" id="SPAL_0000059300.1">
        <property type="protein sequence ID" value="SPAL_0000059300.1"/>
        <property type="gene ID" value="SPAL_0000059300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20015">
        <property type="entry name" value="FH_FOXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000059300.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49279" checksum="95CBB1547136415C" modified="2015-12-09" version="1">MAGQDYTTAAMMPSYSTATLNGYNTYTYPYNAVSAAYATPYTTGNGTNYGAFQTNPAFFQNGQTLNSMTHSNIDMSEQSRADSNNSDNSFTSTTNTKSGEQTLTAAELARIKKNGYGQAKPPYSYISLITMAIQRSESKMLTLSEIYNWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDRPGKGSFWTLHQLCGNMFENGCYLRRQKRFKLQDKESKRNRRTIRSSDASPRDDHHQQQQQQQREVVTLKDDGMLATKQEVDNLNNSPTTASPSSNIENISTTNSPGTQLASIIPQQLKSESATTILQPIGTVISTSPTTVISSAASLPQMSSTTYPQQQHQQYTNPTSFQNIYCTPTTTTIGGDFCNTINASANQLTINSLMDSKTFFENNLYTTGNNIQYFAPMNNGNVLDYSSYTQSLYNDNGSINNQQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Z5</accession>
    <name>A0A0N5B4Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0000114300.1">
        <property type="protein sequence ID" value="SPAL_0000114300.1"/>
        <property type="gene ID" value="SPAL_0000114300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893781" evidence="7">
        <location>
            <begin position="19"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000114300.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="51322" checksum="99CF134E0DDE572F" modified="2015-12-09" version="1">MLLIIAILLSTLLYKAQSESDVSPMMGLPPYPKKPNFIPYFFDVHVRNIVNNIVSQSVLNTDSEDEDDFYGNFKSKLRLMLEEFKNNTCLQFDETNKPADKIGINFFVSDNDKNHVELSRSKNSPTILRLTRKVYEDPFKFRYFFAKALGLMPEIQRIDRESELTIFKDSIDESFYKDYEKSTCYYSHFFESDFDFKSAAMPIDNLGFRSPSKHPKHNKIYQSYLEPYYELMLKKGYDFSFSDYRQISYMYCDFSYEENECENGGYPYIYKEDSNPECKCPRGYWKDKCQTIKDFKHQECPTPNKITANPNYQEMTLEARSSNCYINITASKSTGKVQIYARKLECNNPYRCKYNRKIDSIEIKYRDDKGVKGISLFTSQFKPIELPALSNEVTILWIFGGNDFTPKFTFQYREVIPESKWPYWMDKSFDKMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5B7</accession>
    <name>A0A0N5B5B7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5B7"/>
    <dbReference type="STRING" id="174720.A0A0N5B5B7"/>
    <dbReference type="WBParaSite" id="SPAL_0000126200.1">
        <property type="protein sequence ID" value="SPAL_0000126200.1"/>
        <property type="gene ID" value="SPAL_0000126200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="99"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000126200.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37089" checksum="0733222F57E3966C" modified="2015-12-09" version="1">MLAALEDRRSKIFMRTYDPNVFIVTTNYAIKYFRKNYSNCREPDVVIVDEAGQMSLFNFILLAASFPKSKFVLFGDTKQLPPYIPMEYTPDEEYNILTTSIIEFLDFMNETPKTELSLSYRMHPYLLKLVSSAFYEEKLFTDIPEAMRSIVTTRLNMPSNCPIAWFDTKGYDHRSDMKTSTSNDTEAFFTSTFIRKLLDFGYEPSQLGVICMYKAQVSNLCSIIKNENITIDTVDAFQGNERDIIVICTSKTARNASDVCSNFLGDSRRINVAISRARCGLFIFGDIEFLARNASWNPVTSFFRRSRAVDYSYNMKYLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6G8</accession>
    <name>A0A0N5B6G8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase subunit e, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6G8"/>
    <dbReference type="STRING" id="174720.A0A0N5B6G8"/>
    <dbReference type="WBParaSite" id="SPAL_0000165700.1">
        <property type="protein sequence ID" value="SPAL_0000165700.1"/>
        <property type="gene ID" value="SPAL_0000165700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000165700.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9013" checksum="FF0DB1CF455AB70E" modified="2015-12-09" version="1">MNPAIRTYLQPLLKVQRTFLNSHEDFGRANLYRSVIGTYIGIYFLSKWNSQRKAKALAHEKVAQKENIVRDALGRCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Z2</accession>
    <name>A0A0N5B6Z2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0000182900.1">
        <property type="protein sequence ID" value="SPAL_0000182900.1"/>
        <property type="gene ID" value="SPAL_0000182900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000182900.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16955" checksum="BE825DDA9BE30437" modified="2015-12-09" version="1">MDSKANLFNKEGRKGGYRVSKNLTNINYQNHYTLQGGDVKKDVTLTNASYLNHGTLGTTMNRGYVPYPTALYATGNFVKATRLGSQKSLQHSPYPIPAVTGIVPSSSAYAEPQLSICTDDSVSSNATPLFLSPDYDISPKVEDNKKSNDKLSEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B722</accession>
    <name>A0A0N5B722_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B722"/>
    <dbReference type="WBParaSite" id="SPAL_0000185200.1">
        <property type="protein sequence ID" value="SPAL_0000185200.1"/>
        <property type="gene ID" value="SPAL_0000185200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185200.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12832" checksum="6AB5115CD8AF4F00" modified="2015-12-09" version="1">MGPTSLYPKGVSYSVCRNSMSEFYIFVINALKNILIPNNFCSLEMNVCKPGETPSILSCLQDLCLDGLPKILQDICKVIPADPDEAAYFIGLKPRPEEEERQKHILRDILKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B749</accession>
    <name>A0A0N5B749_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal_S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B749"/>
    <dbReference type="STRING" id="174720.A0A0N5B749"/>
    <dbReference type="WBParaSite" id="SPAL_0000187700.1">
        <property type="protein sequence ID" value="SPAL_0000187700.1"/>
        <property type="gene ID" value="SPAL_0000187700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="50"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000187700.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23066" checksum="2771429FCE5467FF" modified="2015-12-09" version="1">MAEWDTTAEGVTDAIVDAPEIKVFSKWSLADIEVSDISLVDYIAVKDKSAKYLPHTAGRWQVKRFRKAGCPIVERLASSLMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPVQVLVNAVINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQALWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7G4</accession>
    <name>A0A0N5B7G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7G4"/>
    <dbReference type="WBParaSite" id="SPAL_0000199000.1">
        <property type="protein sequence ID" value="SPAL_0000199000.1"/>
        <property type="gene ID" value="SPAL_0000199000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000199000.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="47014" checksum="2063C8E6CB50E0B4" modified="2015-12-09" version="1">MISVTVAAHGLRNRRTIGTHFKAYDSGRLLIEDDTNMEEVTKENDDFAILQNRKRGYFCSFISYIYSLFSKVCSYLLTFCNVYVPIWKLFKTIRYNEIPTRQDKYLVKNRNAPPLQNAFILRKIFAFMNVNELMKVAKVSKMWRNVVKTYSEQFDHIQFDQVKINLDEGQIIIFPLDTQRDPKKFTIQSLRELENNMKHIKVNSLFIRGMIKSESKIIMRLLNCLSLQPSQFYCLYCDFCIDAIVELKKFFTLNQQYINDIGFEECSPNEFMVDDMFIPSIQRLLNLRIINTTSYVQLGVTDKFLFEIIDNAEKTKLFKLQFLMINRPRFTVQAFIALMEIWYKYCKEDLMITLQNATFTMNDLIGQCHATTKLRIIDKRFVECNNFYFHINIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Z0</accession>
    <name>A0A0N5B7Z0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exportin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Importin-alpha re-exporter</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Z0"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Z0"/>
    <dbReference type="WBParaSite" id="SPAL_0000216400.1">
        <property type="protein sequence ID" value="SPAL_0000216400.1"/>
        <property type="gene ID" value="SPAL_0000216400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000216400.1"/>
        </source>
    </evidence>
    <sequence length="971" mass="109783" checksum="7A08EF4E70DB1945" modified="2015-12-09" version="1">MDNNVEMVLNALQGTLSSDKEIRQSAEMQMSQFTENAGFCCTLLKICDTRSGMNANIPEAVVTCAAVAVKNFIRYQWTGSSGTAPLDQLEREKIRQSVLEVLFGNSGDKKVRDQLLSSLTLIAKTDFPEQWQNLATVLSEALRGGISESAKVSVISMDELFKRYRYEMKSEELWREIRYVLTVCAEPITKFFVEVVKMVVECSEKRNYTPEQCKEMFDCIFYCSEIFHSLNSQDLCEYFEDNLKTWMEAFLALMKINMDFYPFSPSNEEDPYNKLRVSLCEIFTLFSQRYEEEFLPYMQPCVELIWEKFFANGNADNCDSLINASMNFLGAICIRPQYQSMFTAEGVLALLLRDIVIKNMVMSQDDIETFEDDPAEYLKKDLEGGDAHTKRRGAADLLKILSTDYPAQVTPIVQDLLKEFVGAFSANRKSNWLQKEITFSMITSMLIRGETARMGATKVTDFVNLDDFYTQYVRPEIVESLPDELPIITCSALKFAFTFRHKLQPLALKELVSGPVVGRLLASKNQIIHWYTGNMIDKILNTKTRDNKLLFTSSDVDTPALIGSIAQILELRSTSITPYVIKALMRVLSFMDDSTAAGADNIINALAKLSFTALKQSANPVYIHYIFECMCVVIKKAYSKVAGGIDKAVLPVIEHIFTENIEDYIPYALQISALLITQCSAAISRGENVNSDAYHGFMQFVLTPQIWQHSTNAPAGVIALEAYINAFPNQMFSEENVKKLFDIYNRLIGSKANDQHGFSLGNALLPYLNKYPSITVQSLFIPIFSRLSRSKTFKLQKNMMIFVCRFILVVGADEFVRSVNAIQDGLATMTMNRVFAIELTGIAQMTTSFERKMLILGMAKLFESQPHVISESFGALFNGVVKLIGASIKGISNVSSHVEVDEELVFDEDNFNNKFCRLSVSRPEEDIFKEYKQYHRIFAEAVSKLQGSGISFPPECDESLVLLKKYVETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Z3</accession>
    <name>A0A0N5B7Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Z3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0000216700.1">
        <property type="protein sequence ID" value="SPAL_0000216700.1"/>
        <property type="gene ID" value="SPAL_0000216700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF4">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000216700.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45132" checksum="E6F32CA63F4BAE6F" modified="2015-12-09" version="1">MEKKQKILYTLCLIFGIWHFGTQWTTTLLSFLQWDTTEVMSIVDLGYIQSFGSLMNVIGALALGQMTDSTGPKTIFIFAVICTSLYYCGLALCHTWIAFFILQVLRFGYQLDSTAEMYLATITTEKERTGTLMILTIPQAIAMFVGPYTASKVAVWTDLRTSQFLSGITMFVAIMPVIVFALPATHGIPKIAAARLRPQEYWPMITRNPALRESLILRGFLVGAYVCYELIARNFLLRQYMHGATDSAYVLIVMGIALLTMQFLVLPFLQKRFTPKALLQMALGTLLFCYLAVNFVTGLEQFLLINGIQTAAYAICYAESCTQITSSVESTDLGKATGLASMTQWLTHLIVPIYTSQLVQYFQFHYAFYTSALVIGCLLIYVSVVAKHYNARVRSLLPSLQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B821</accession>
    <name>A0A0N5B821_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ApaG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B821"/>
    <dbReference type="STRING" id="174720.A0A0N5B821"/>
    <dbReference type="WBParaSite" id="SPAL_0000219400.1">
        <property type="protein sequence ID" value="SPAL_0000219400.1"/>
        <property type="gene ID" value="SPAL_0000219400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000219400.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="90259" checksum="85CFD07BD76C431F" modified="2015-12-09" version="1">MSSDLEGLDVRILPNLKSTSDQIKKCISINLLQACQREVNFLRMIDRKAPILYDNNVIKNAIRRYEMFWLPMQASCPDVERIPPLDVHWVWHVHMLSPHNYEMDCKKICGKVIDHKLQSAEEIQKRYEQSVCSWNNFCHPEPYDFISSTYYSKNNNATSSPIPRRESYSTTSFSSLTSVYEKKSSYDILAAVSRQRNFNYQISLPHYTSPLFLKEAIDRYINFLLLKQTYDDKFLTPCYDFDLIWHTHQIHCLAYQRDCIAIFGHLLKHDDSVNDRTPNSKLLQGEAITKKLWGAHFKDGFWRRGCMYRGHEAPVFIGFEHQDMTNITYGHIHIPSISLKEIPIHRAQLRLKLYYGTKKITTFNADLSNRHVTKDSFSLLWQPSDANGDAISGNPSYSMTSIVKFPFETASPKDLSIELSLFDKLLLQKKDVIKLSGKINLESLLPSPGYKACQKNVQITLTSSNNSNIGKEYVAKINASCTVSLNRELELEAGDYIDTKIKKDSRLWSFIHAASLNKSVLENEVQVSMATHRLVDHRDGATYIVQIVHSATYLLSMIIVYDSEQRLLSMAHLIGSDSLPCKGQLDANLQFLPHLSAPEERIFLVSNRDGDFSIVKGSWSGYVKKNYSDKHKNCKQSHAGHLKVELFNLLRNTIQKLQLPAPDGSTLFIIGDAQARLSGKRFHCRSPMVAEHIASIFAVSTLFVLCNPDRIHDKSDSSHNMCHSSHKWPMTVASGYGKRIMYNDQQSSNNDWNSFVDITPAFLVSCSDICDGYNGFDGVAACGNCGGCGGGGCGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9F8</accession>
    <name>A0A0N5B9F8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin-14</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9F8"/>
    <dbReference type="STRING" id="174720.A0A0N5B9F8"/>
    <dbReference type="WBParaSite" id="SPAL_0000267400.1">
        <property type="protein sequence ID" value="SPAL_0000267400.1"/>
        <property type="gene ID" value="SPAL_0000267400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="95"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="316"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="551"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000267400.1"/>
        </source>
    </evidence>
    <sequence length="944" mass="109022" checksum="3587654035799B31" modified="2015-12-09" version="1">MDEKNIKLIGIIFFLIFCFCYILNINATTLICCFVSLIIGASIGSGIIVNADEIQGIIDRKLKKKYIIDEDMVNGSKKKDIKNNRYDENLLFYVEEELNEKIELFLERIIERYINSWYLSEFENDTAFIGEIRHHCCFAGRRILSLIKKTDFEGLIIEEVLPQILLHFQRMGNCDNEIKEDKSTLCEFFKDDSHYGLRGNLNCQRYMNVLSEKILRKIIDVKRISGKVGDNNSVNCTWPSKTGLYLLQDLVTNFIFSPLIEFLSEPDNINKLFLQLVDGSPTNDTNINDNKKEVMFLHGLEEQIHCTIQDSLLQVKLGKIIRDPRLLQTFEIFLEDFNGPLALLQILKNLDGIHKTLIKIEKVDDSEMVLREIEFDLHQIYATWKVFVNENEKEIIKLNTLFLNESMFKGLKNDLDNKNIHAIDKVIEEAYRKVYEILSKNFVIPFSQSECFFGYLCGSSPVDVDQFQLSNNALSIDSINGSNCGKIPENSLSFASFRKRVWSVMIPNTNDSNDDLEDESYELAPSVETPLDTAEYNNLGILTILKSSTKLSIRIEDIEMRRDSIASRTYYVYAIAVISTDISTSEPTSVEWTVLRKPEEFYILQQKLLEKHGSALTQFQSLPPKKSITSRDKIALLENLHVFENFLNDINHHSLLQRSDLFFNFLSTPDEFKDSLTLSELNPWRIVKKVPQKLSREKGQNLKSFILNSLANLLAPPSSNVYSYYGRSHSNFDTFSFNDNMSSSSICDSELLSTKYKNSSNNKNKNYSNMITSKNDGDNCIDECLSLSLNIDKKMKPNFYNTLLIFLLNITSLPTWILYPALFLEYLFSNVISSYITNYLTNQINLLLKPSTFSSIITSIHSTIFDSNYEVVTTEEKNLRRQLARRKFKDISLSIIPFYSYFKMDLKKYEHSIENIFNASQCQELNKQLVIVVLDKIIDNLFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9V4</accession>
    <name>A0A0N5B9V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9V4"/>
    <dbReference type="WBParaSite" id="SPAL_0000282400.1">
        <property type="protein sequence ID" value="SPAL_0000282400.1"/>
        <property type="gene ID" value="SPAL_0000282400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893962" evidence="5">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000282400.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16624" checksum="92FD6CA771EC6916" modified="2015-12-09" version="1">MCKSFIFLLFLFYCFLNLSNSVSLGGINQSVGVKGRLLCNGVPAEDVLVKLWENDHFNFDDLMAQSTSNKEGFFRLHGSNTEYSSINPRITVYHYCNSPSAICARKFSIIVPNNYIFKGEFAEDFYDAGDIHLDEKKKGEVKDCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9V6</accession>
    <name>A0A0N5B9V6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9V6"/>
    <dbReference type="STRING" id="174720.A0A0N5B9V6"/>
    <dbReference type="WBParaSite" id="SPAL_0000282600.1">
        <property type="protein sequence ID" value="SPAL_0000282600.1"/>
        <property type="gene ID" value="SPAL_0000282600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="801"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="734"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000282600.1"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127079" checksum="FF19E00164ADF7B1" modified="2015-12-09" version="1">MLDFGTLIAFNQSELDTIKSLSSFSFPVFHKYRTENDVGQLEVLFKAYHYLNKCYSILSNDPKFDQTKLFNLEMKLAHLCLVGGDEVRSLSIYQTLLNKNETLFSKSFGAFFGLGITYFQLKQFKFASEAFLKHLFIFEDEAVSVNAHCYLGLIYQLQFDFNKAVKHFTIAQNFSKEGYVLSKEEIRFSIAHCYECAGDSERARREYKNILDELPNNIPSTVQAAIYRQLGWLNFKAGKIKEASELLEKSQIINPNCGRTAYFLGRLNSEAKDKAHFAFTQYRQSFDKGESEADTWCSIGVLYRQQEQTVDALQAFTSSLRLDPKHSITWYNLGDLYEKHLNFHDALECYKTAVGFDFKEKEKVKKRIAVLEKELQFVSPEQLAQNSAQLIKPPPLKEAMQLTLPTEIRHTIQKAINKRITTHFEGGILWTSPELLLYTMKRAGHNIQLPNDIRISENLKHILSYNKDLLETSELQALRLIEEAFPKYRKNNIYNYGLSQIKCSEISNDFKDIKTEYVDESSNVGNIKNDTETNNESDVKMEPLEYILQKDQDCNVSSTQDEFPSYFSLLSGVSIPLSSTSDEVIKAASLRSTNLSEYVPIYKENEMVKLFEIPSEELSSSQLTPPTPLLQVETVREAHSIELQNFCYNASPITCIRGLTSTLKIDLGLFSTKTLLETVPNHDVEVRTQYKFPYDVNTNHAGEKSWEYYSKRSFTNVMSYAKYQAESFKKSMKEETEKLKNIPSGKYNNQGNNDNEHSGPQPTKRKKTSMSKEPHQEVKPSNIPMKTIKFGTNVDLSDPKVFSNQLKELGKLPAFCRLEASCNALTHIDHIIFGMNTVQLYMKVPGARTPAHQENNNFASININTGPGECVWYGVAYEYFPKVERMCRKRGVDFLKGSWWPAIDDLLEAKVPVYKFIQKAGDLVFVNCGCIHWVESTGWCNNIAWNVGPMTSFQMKTAFFSHEWNRLNGFKSLVPLQHMCWQFAKNVRFTNSKLYKMIRTVLIKSISYQKMLLDYLGTLSKIPKSQPRDKNEITHYCSLCEIEVFNILFVKENQGGVYNVFCANCSRKSNQQFDEFIVLQQTPLETLCEIFDLFQLYPTKHPLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA25</accession>
    <name>A0A0N5BA25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA25"/>
    <dbReference type="STRING" id="174720.A0A0N5BA25"/>
    <dbReference type="WBParaSite" id="SPAL_0000289400.1">
        <property type="protein sequence ID" value="SPAL_0000289400.1"/>
        <property type="gene ID" value="SPAL_0000289400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000395">
        <property type="entry name" value="zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000289400.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="87370" checksum="B5022447BCEC750A" modified="2015-12-09" version="1">MSFNNTNDYITSTSNSDASIKSAFKNIPIIEDESSSEKPSVIMKIGSNRSAFTTIYNPQIENNNNTKSMETDENVKEVHETKKQINKPGNIEISKILPPRIYEQGPSDPSSPVDQYKDECKNDSPFLTVDAMQRINLLSPSYAIDINKLCPNYQSNYATSDLGSSTRSSFSISPTTVQLNPLFANFRDSKRSTDYDTDSDYCSKDLLSPYSAFSPSPFTPSDAYSELPETPYSGFVSNDGRSPILSPLPFNSSTLSLHFNFDGQQQRSTSSLSTSRCHEDTSHSQQFFSNFLLPNNLSSISRERSKSEGEMLAESLNAFNESHMMSTLNVPDNQHRHRSKIAASNNIKKEHRIRNCYSPQTHYLEKNFLKPKFDDTIIKSTNIWDTIGNDYLFGNRSSSTPPPTTKESATLEATILAKEAAAFHNASNLLLSSKSALNLNILDKNISQLNFNDTTSTNYWIETQLQAINRAISVNSIPPSTSQHVPSISQTIAPTPQFLTPSMGNYASQLLALSLLQNNSLSISKSHSENDLSNSKKNFQSISQMNVMIDSKQTNTLTKTFPDSPTTTSSSTRLTPTKTSLIPPIGAIPISCGNEAYVCPICGQAFALADRLAKHIASRHKDPNIDPITIEANKIHKCNQCGKKFGRSDMLTRHLRLHTGVKPYSCNVCGQVFSRSDHLSTHQRTHTGEKPYQCPQCNYAASRRDMITRHLRIHSKTEENMSAEMISKINISQSTSNSEKEQLNIKTTLDVPTISLSSPMDTNSINNEEDFKNKAKIIFKSNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB08</accession>
    <name>A0A0N5BB08_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-lactamase-like protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB08"/>
    <dbReference type="STRING" id="174720.A0A0N5BB08"/>
    <dbReference type="WBParaSite" id="SPAL_0000322200.1">
        <property type="protein sequence ID" value="SPAL_0000322200.1"/>
        <property type="gene ID" value="SPAL_0000322200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000017">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001018">
        <property type="entry name" value="Beta-lactamase_class-B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00743">
        <property type="entry name" value="BETA_LACTAMASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000322200.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34125" checksum="E38C99D146C519B9" modified="2015-12-09" version="1">MLGSFRNYIDYTAGVGAYLISKFIKPSMAPNLTPLENISKLSPVVTRILGQNPGSFTLLGTNTYLVGSGEKKILIDTGDKNVPKYIDYLKEALNGGTIDGIIITHWHGDHIGGIPDVLKVVGKKIPIYKLKRPDVENEEQSQLYNYVEDGHVVKTEGATLKMIATPGHTKDHAVVLLEEEKTIFSGDCILGEGTSVFEDLYTYMNSLNILLSIDPKTIYPGHGPVITSPKDKITEYINHRNQREEQILKCLEGKEYMTSMDITNSVYTDILLSVKIAAWINVKNHLSKLLKENKITEISTDRFKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB12</accession>
    <name>A0A0N5BB12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB12"/>
    <dbReference type="STRING" id="174720.A0A0N5BB12"/>
    <dbReference type="WBParaSite" id="SPAL_0000322600.1">
        <property type="protein sequence ID" value="SPAL_0000322600.1"/>
        <property type="gene ID" value="SPAL_0000322600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000322600.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55380" checksum="770788024CFCDCD5" modified="2015-12-09" version="1">MVCQGTCGDLEAYEKMGIPPPIVDIKPKYTKLFINNEFVDGVNKKTFDTINPSNNEVICSVAEAEAEDVDRAVAAARAAFKLGSEWRRMDASKRGILLNKWADLIERDKTLLASLESLDNGKAYKVAYTVDLPLGIATIRYYAGWADKNSGQVIPVDGDFFTYTRHEAVGVCGAITPWNFPVFVALLKIAPAVATGNTVVLKVSEETPLTALHLAALIKEAGFPSGVVNVISGFGLKAGEALVKHPDVDKVAFTGSTAVGKLIMEFAAKSNLKKVTLELGGKSPNIIFDDVNIDEAVVQAVEGVMFNQGQVCIAASRTFVHAKIYDEFIRKAKNYVEAKKIGCPFDPTVDQGPQISTKQMKTILSYIESGKSQGAKLITGGERFGEKGCFIEPTIFADVTNEMKIAREEIFGPVMAIFKFEDEKDLVEIANDTIYGLAAGVMTNDINKALYVANSMKAGSVWVNCYAVLCPSAPFGGYKMSGIGREFGEYCLKEYTEVKTVTIKVPQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB30</accession>
    <name>A0A0N5BB30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB30"/>
    <dbReference type="WBParaSite" id="SPAL_0000324250.1">
        <property type="protein sequence ID" value="SPAL_0000324250.1"/>
        <property type="gene ID" value="SPAL_0000324250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000324250.1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7247" checksum="BABDE25AD2BF82C2" modified="2015-12-09" version="1">MSDSQHQVRLSKKRAKLKITSNGGLHNFQANCNTYIAGQRMLYLSQNSLISCKTPHPQNLSFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBU0</accession>
    <name>A0A0N5BBU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBU0"/>
    <dbReference type="STRING" id="174720.A0A0N5BBU0"/>
    <dbReference type="WBParaSite" id="SPAL_0000349500.1">
        <property type="protein sequence ID" value="SPAL_0000349500.1"/>
        <property type="gene ID" value="SPAL_0000349500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000349500.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12655" checksum="19990E8EB1B6354C" modified="2015-12-09" version="1">MQKKIINEARLFSKLHHPNVVRYYNAWVSKCVICKDGNNKSTPADNIDKDKNIDDVNSKSKSKENLDSYAGWEPSYAYKDNDYSSSDDSDNEDNDEESVGDSSRITPVSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCC2</accession>
    <name>A0A0N5BCC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000367100.1">
        <property type="protein sequence ID" value="SPAL_0000367100.1"/>
        <property type="gene ID" value="SPAL_0000367100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000367100.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11006" checksum="60722864749B97FF" modified="2015-12-09" version="1">MPYVLPNVVIYLENLVFKNGYVKKSSQIKFKYCPTCLMIVDDNDCHPIYDFPKELLEISLADNEDEFDSEDDAMRQYLQGILKEKLCYNEKVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD00</accession>
    <name>A0A0N5BD00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BD00"/>
    <dbReference type="WBParaSite" id="SPAL_0000389300.1">
        <property type="protein sequence ID" value="SPAL_0000389300.1"/>
        <property type="gene ID" value="SPAL_0000389300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000389300.1"/>
        </source>
    </evidence>
    <sequence length="2063" mass="229767" checksum="9F2C99C68A605166" modified="2015-12-09" version="1">MEGSQSLLLNEEAFKVCPDPKKPLFIYEWLRFLDKVLSATNKNDLKSCQKELISQLIGRINSGPGPSTRNLLSKCIGKIYTIGDSIDLFNTIAICNDILKGKEESSQQLSIKLTALSVLSALYESVGRLVGRSFEETFAIISKWIKSAESMVRAEILNTITKIILGLGNASTSIHKDTYKSLVKPYLTDRVLSVRIAAVNCLHALVKEYTTLHTMDIDAVATLLIKSLDVSNYNTRLAVADVFATLTKLAIKNTQAVNGQGQSNGNGKLWTIESSFNLLSDVFIRGGIGGFLKSTVAITNISSYSSSKEIRNGITLAYIKIIKTMGGRWLEKNQSFVITHLLSVASKIGPIASSDNPTQLQEALHMRRCISFIFRKTFGQIISEHTQVSVCKIFGTLLGEFISSYEVLSETNTETLPSVKHISSSQVCTVTLLEISALVQQIGSSVANLFTDASGIMEPVFASLLHPIQSTRVAASWALRCIAFAVPSLLTPLIDRCISRLEHMKTFSVAIDGYSCALASLLTASKLSPLGIPFSKSRQIFQLAEDLLRSASSTSNITQQKVKAAWLLLTSLILSDPLFVRPYISKLKIFWKNSFPKDKEEAEAENQRGDVKTWIFTLTSRSGALASMNAFYVSCKEDMNENIEKKLYNALESSLMTLAQVATLLKSHGAALRPFIFELKIRLYELLINMETGKYNSLNPTLLRELVADISLSDNSSSTTITSLSLSACSLMESNFLGGWLKTTDESTIEMEIHPNRSHLQVIDSLENDVFESLTYTKLSQEYWPELITPPVKALDLSIVVFSRLYPTLASKHKIQLTEHFKEVIKSWQRSPARQYSIQLNVLTALLFSIKCLSECRNAKMDNDNLRKTNFELISTYINHEKVPLRCLAIEFLSRMAQVTKDASYVAGIAQYCFDKLHTLKDEKSRASFGITIGVLHNYVGSLGSSQHLNTSVSITLALAQDPSSPTVQSWAIFALSLIANTGSGMFKAYVEPCLSLCLRLLLNVSSHHIDIIRSLGKLTSALITAVGPELQSAVGSAENIRSSFLVACSMMFENSDSFVKAEAIACLQQLHIFAPRFVELDWLVREICHLMYSPHLVLRKSSIACLKQLLQRESIEVKEHASNLVPQSMIERHDSKSDCILPETGLEGALFELLDIETDPEMVCNIKESIIFLVQATGGEHLNFWMIMVKDILASSTNEISLMNGEKDDGDKGQEEDDDSTFNVSSKRTEHAKEKLLPRWPARVFALEVVQKLMQLCEIERAHLDLALAKELQLSSSGKADYLVLHLSDLIRMAFMGATSNNTHLRLAGLTTLQDIIKRFAHVSEPEFPGHVILEQFQAQVGAALRPAFEQDTPSHITASACEVCSTWIGSGVVRDINDLKRVHHLLVSSLTKLKNTSNNITPLYNESTATLEKLAILKAWSEVYIVAIEKNNEENPLLHLVDPELNFLVVYWMAALRDAALLSLPPEYSNQLPDDGGSFYIAECVDSCKDYYRDVWPTILLASSIWLSKTNFELTSPQLPTCRNWKDLSKETRFDIIIGMCLEALCCVRNIGDIDNRVRLCLKSLHFMMKSVWFQEKLMSDVEKCIEIVNALHRIILTRDNLGTQKLCGEVADGIIKVVIRMKEKTNNGGGVYIGNEGSDGCFDTKRSLAFALLEFCLCLLVRQIPQINTALMNSKTMTPLHFKKYSKLPYEGHELIKIALQLLAQIPSLCHYRGTIIILPSILYMILGVIRESARKDSEQIIGDTPPGHVSLVSATAIQSLRTLLSNPIRDDDNIITDDNGNKIYDSEKDEIFQEWCTEIRSAMYSLSLMDTNLNIPVDQAIILLSLTVMITSVPQDFILGSQLFGKICRIFKSVITSDNVKVKLTALQGIISIFSKKDISKSYIKILGPLVTVELKKILDKANALESLPQDIHELDESDYLILPELCKILTTILDNISDEKQFQLTALLIQVLASFVIPTPEIKFKNTSKNGKQLNDFCLNQLTYLARSYTDNFKKCISVVPGLKMRIEDGLKHQGLRSTQQMQMAQMMAGGSRKSQVKASNVGTPKIKLATDFNTKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF8</accession>
    <name>A0A0N5BDF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BDF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000404400.1">
        <property type="protein sequence ID" value="SPAL_0000404400.1"/>
        <property type="gene ID" value="SPAL_0000404400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894406" evidence="1">
        <location>
            <begin position="23"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000404400.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68149" checksum="1F26D3900BFFECED" modified="2015-12-09" version="1">MIGKLSYLNVFLLFITISFIYCESLRPNNVAINEKLKHIEVDSSWLDKNGKKVQRVGLDASDAERVILNLLTEKKQFSASAHGNVAAAETSDGKRAQVQKLGDKGGIATVDGHKGQIKFKEDKEGKHALLKADSKYDLDTMVIGDMKTVEGTKFKATNDRFDFNLNPNTMDKNGGEGMLGFNDKEKNTKGNYAYTIKQNGKKTEAEITSKSLGDKDGFLDNLFNRRSDKYRCVAETPGISQCYDEQGKSVGKVVADKAGNTVVYNDKDVPIGTGTVKKIGDRSYEATISKNLFIARLKDARSQKCCKEISGKDCIAPIKLSKPKFSHPSRTDENGTKHLTWPDCFDMSIEVTLPKGVHIDKLAMKLDVNIQPIGKLRCMDVATCGRECFYCDWCKESRKLKLLENNDGNLCRSTDERTYRLTVKLCPPPEDPNFTMCSAFSKSVWQKDYWQKEGAVDVWMKFYERGSNRAQLEDEFFAQIDNPILGKAFKLAIIAEWLAANSLDQGSYQPSNAELLEYWVSKRNPDVLLACEHAVVDYEIEGAKVKSNLLFEAATTAGNIPNIFKDKKCSKFEEFQEKRFQEEARSYKQRTGGGSILSGLKNLFGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEN4</accession>
    <name>A0A0N5BEN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEN4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000445800.1">
        <property type="protein sequence ID" value="SPAL_0000445800.1"/>
        <property type="gene ID" value="SPAL_0000445800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000445800.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38665" checksum="83392BDD98D21CBF" modified="2015-12-09" version="1">MKKIEKDSFIWKIESFSLSQLIEDKGRISSFFTSKRNNTIKWSLTMYSKDLYGDNKDYISLWLKLEDSSCFELAVLCGFYVLSVDGEKKHKEVTSIRKLNGIFTVCPCHQFLKHDLLLSNDNNELLSNGNLIVGCEIFYYFCGISTANLSKNNNTEDTLDVLLDDIADLVKSSMFSDCDIKIEDSKINACKCILAGRSELFYSILAEQQYKTIPNTIKINDFCLDIVEKMINYLDTGKSPNMSEMALEMLKIAEKYNLKKLKLIAEESLIYNLSIENACEYLVCSELYSGEILKEWSLRFIYLNGENFFNSEKWKDVVSDHPLFVGKLFSVTFNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEP3</accession>
    <name>A0A0N5BEP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BEP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000446800.1">
        <property type="protein sequence ID" value="SPAL_0000446800.1"/>
        <property type="gene ID" value="SPAL_0000446800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000446800.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10892" checksum="F994337DE43044A6" modified="2015-12-09" version="1">MHEIASGLMDVLKYGMDRQGKHLLPGHIVMKRVMHKKLSHTSHKNQDQFDGPYTVISHVHEDTFIIRRCTKAGRLTGKEERVTADRLKIVPVHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEX6</accession>
    <name>A0A0N5BEX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KASH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BEX6"/>
    <dbReference type="WBParaSite" id="SPAL_0000454600.1">
        <property type="protein sequence ID" value="SPAL_0000454600.1"/>
        <property type="gene ID" value="SPAL_0000454600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058344">
        <property type="entry name" value="DUF8031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26081">
        <property type="entry name" value="DUF8031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8031" evidence="2">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="588"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000454600.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="83456" checksum="8C4AB811451D0C02" modified="2015-12-09" version="1">XNIHLIEEQLSKLPESSPVYQELKEKADNVKDEVEKIKNANKSFDEINSLLKSITNSSDDNVSLPDKISSTNNKLATLRDEVLPLILAIPFSNIPEVDDKINEKQHEINELIKYLKDKLADDQKTMDNLELGVSLIKCMSKLSQDADNSVDFSNPEESINRLSDILENLKDKLHSLKDVLTDKFSTNDENIIIKGIEIGNNDVKKITNYIDNLKKHQEEIKSLLDHKTNLSNKCIKDFVDADEILNRYNEKPQPYDVSIKDIKNIAPIINRLNYLIAQNEESVKLFSEKKLPIDDISESINNIKSKIDALKCLDDEISQDIERENALISRKITLNDSLKDLINRSNNVIEKADEPYSFDEIKNEIHMLEKKLDSAIVDYSVPLHVILHSSDSDASELKERLHDIFMALNEQKEKALEKLEQQKVVSHISEVLEKIKETVHDAETVEYDPNSSADDLRKVIERLESTNQSLLQKLDDDFNKISNVEDLNSQRNKLTEEKNKHLEELNNIKSKISERLDSIAELNELLASVNNNINKISKKIKEIPIDDLEHVIKCATDDNNSLDELISEIIRVAGKANKKDSPEVCDVVEKIKEINKKYSEKMKQAEIEEEAKRKTAEEQKQAQEEIEKLVAAPLNEENIHLIEEQLSKLPESSPVYQELKEKADNVKDKVEKVTSTKKNLDNVDNLLKPITESINEDIPLSEKVKETEDKLTNLKEEVKPKILAISWTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFE4</accession>
    <name>A0A0N5BFE4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine synthase reductase</fullName>
            <ecNumber evidence="11">1.16.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.16.1.8" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFE4"/>
    <dbReference type="STRING" id="174720.A0A0N5BFE4"/>
    <dbReference type="WBParaSite" id="SPAL_0000471000.1">
        <property type="protein sequence ID" value="SPAL_0000471000.1"/>
        <property type="gene ID" value="SPAL_0000471000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000059">
        <property type="entry name" value="5-methyltetrahydrofolate-homocysteine methyltransferase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="238"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000471000.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="75663" checksum="E3A03F74A5D6BE59" modified="2015-12-09" version="1">MHIINNDCFTIPKDFLIIYGSQTGQSESIAKQICDRSIFLGFQPRIFCTSQSEKDFYIEKEKFVVVVISSTGDGDPPENSARFMRRISRKNLPEKWLSNLNYCLLGLGDSNYSSFHFIPKKLDKILQKHGARNFIETGLADDQVGLELIVEPWIENFLSMLKGEENIKKIKMSEVTLNNDQTENVTIRNGSEKLRNEVNLRVPQPALEYLFSSVNEVKITDFSTIPWQNNSKFPGQGSSFYEADVVGVIKITDSDLNGVKEKREIHLEINTGSNELLKYEPGDSFYFITPNEKKDVDKLLSQLNILTIADQQLQFHIKPETKKSNPTIPEYLPNNASLRYIFTYCLDIRRTPGRPVLRVLAEYCKDENEKRRLLELCSAQGMSEFNNLIRNAAVTLTDVLVAFPSCKPNVDRLIELLPRLIPRPYTASCYHSLWKNRIRFVYSLIEFPAENGRQEVRTGLATGFIKGLNVGDKLMVSLKETSKFRLPPISVDSITDGYDIPLLMIGPGTGIAPFISFLQKLGSLKLEKNYNDYCNVPRYLFYGCRNLKKEFLYQNEIKTYEQLGILTKYFVCESRSESNIHSSPKHVQDLLKLNKQIVIDFLKIPNSRIYLCGDGIGMSKDIYQCFLEIIKEGYTLDNNEGIALLNELKKNERYIEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFV4</accession>
    <name>A0A0N5BFV4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFV4"/>
    <dbReference type="STRING" id="174720.A0A0N5BFV4"/>
    <dbReference type="WBParaSite" id="SPAL_0000486600.1">
        <property type="protein sequence ID" value="SPAL_0000486600.1"/>
        <property type="gene ID" value="SPAL_0000486600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040363">
        <property type="entry name" value="HMBOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006899">
        <property type="entry name" value="HNF-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044869">
        <property type="entry name" value="HNF-1_POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044866">
        <property type="entry name" value="HNF_P1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618:SF0">
        <property type="entry name" value="HOMEOBOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618">
        <property type="entry name" value="HOMEODOX-CONTAINING PROTEIN 1 HMBOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04814">
        <property type="entry name" value="HNF-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51937">
        <property type="entry name" value="HNF_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51936">
        <property type="entry name" value="POU_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HNF-p1" evidence="13">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="POU-specific atypical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="11">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000486600.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53087" checksum="DAA77C382CE31032" modified="2015-12-09" version="1">MHTNMRLFTVEQLELIRRLRLTGISADAVLEAFKTLEQFENNLESNRFQQAALAAMLMPGTDISMNFNKIPLQNSIGSNLLSSSILTNSNNQSNFDTLSQNPLLFKHLSVGSSSSISQNINNNSNNNNSISSCTNSTSSDKSPSFISEPNSSSPLSFPKAGEEIIKSTEDYPFSTTPPSSNGGRPIRSNRTPMREITTLDDPKELEEFIEKGEENCINDMRQFITQLSLRQTTVAQMTGVSQPYISKMLNGNHKELSLRCRKNIYSWYLNMKKHPEKLSSYLSDPLIRLETNNDGELIPQRRERYVFRPILIKILESFFLEAPFPDYSKRMEIASVCNKALLKEKNGNDLLNKEIVSPQVVANWFANKRKEMKKKTSEEVVSINCSGSINKQSIDMYRNNISPDGTIKSGGSTTEDSRPSSTGGEENNSPINLLIKNTNSGDFSMLMVNALQQQAVFHNAFNNSLQTGLVNTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHX5</accession>
    <name>A0A0N5BHX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHX5"/>
    <dbReference type="STRING" id="174720.A0A0N5BHX5"/>
    <dbReference type="WBParaSite" id="SPAL_0000556000.1">
        <property type="protein sequence ID" value="SPAL_0000556000.1"/>
        <property type="gene ID" value="SPAL_0000556000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="381"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="428"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="598"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="690"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="777"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000556000.1"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123716" checksum="A2E09C4C6B88EF64" modified="2015-12-09" version="1">MQPDTMFGYSIDFMRNKDEYNLIVGAPRAQSAGNRAIAKGGAVYSCQTGTNRCQEILFDRNGNERRLNGSKSLPIEDKSHQMFGSTVVASGGNVLACAPHYKYFFSKFEVIEPVGTCYYAQNNFEKITEFAPCRQEPARHGHHRFGYGMCGFSASIADEGNERLFINGPGVWYWQGAVFSQNIKNITDRPNTADGPAPHDHWQRGYSSAVGDFDGDKKDDVVVGVPRGKDLHGFVSIYNRKLHSIANLTDKNSQQGQYFGGSVGVADLNNDGLDDIIVGSPFYTDYKTVKDIKTQERKPQYDVGKVTVFLQTSVGTFDEGTSIIGTSQWGRFGYSVASTGDINGDGYNDFIVGAPYDGVDGKGAVYIYHGSKNGVVKKYAQKIEGGQIRGDLKTFGFSLATGKDIDKNAYPDIAIGAMQSGHAVILRSKPVIKVEGQVSSAKKNINLDNKNCMSEFGKIACEKVKYCVKYDGKLPAEHRNVDLKVRVQLDSKKPLSPRPFFSRRDIDRKKNVQISSESKNRNQPDVIEQVVPLHKGREHCDTFEVFIPDTIRDKITPINILVNYTYVEKRSLSNELDAALDTTTGASFETELMIDKNCGDDNTCTPDLQLYATTNKDKFILGSEDQNLIVNVSVKNRGEDSYLSQFFIDIPKGFEYGGVENYASTAPVSCSEFVDDELEKEEEDSKKKSKKSKKNDDKKKERKDDYYKMVCDIGNPLPENKDAEFGFILRATSVDPEIEDISVKMSVNSTFGEEARGNEKDNELIIKVPVEIKAQLDIVGRSNPEQVDYSIRNRTKGVRALFDNEVGPLVGHLFQVINRGPSIIDKSTVDIFWPSFGETGKHLLYLIDTPFVSDSQKVKCRVRQAQNINPESLTIGNEHNILSIVANPQAPKKSSQQNGSSRVKRDWEGLTHDELVRNQKKELKDAVLASKGRENAVEYRGSLHKGNVDCGALNCTQITCEIGRMAPDDYVLIEIFSRLWVNSLIDDSVYEADISSLALARITSLPIAPKYSPPPQIFSVTTDVNPTDPEQFAPDLPWWLYLLAILIGLLILALCILCLWRCGFFKRNRPQSEKARLVEGVDKGGYYADNHTRYNQPSMYDSRAHGDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIH6</accession>
    <name>A0A0N5BIH6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIH6"/>
    <dbReference type="WBParaSite" id="SPAL_0000576000.1">
        <property type="protein sequence ID" value="SPAL_0000576000.1"/>
        <property type="gene ID" value="SPAL_0000576000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000576000.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45956" checksum="9463C47DE4F829A3" modified="2015-12-09" version="1">MLRAITNVKKIPIVYPPPYPTNGTEVKYFYDKDLKDLLSTTKGYPDVEEIDEFFNQINKHTCLNFTRSEEIKENKIGIYFMITSYTDHVELSNDENKVTKVSLTRETYKDIFQIRFYIGLAFGLIPEIQRIDRDRELQIYDTNINARFKPYFNMSNYYYKFLKNTDYDFASATHFPNYFGSTGSGITYKPCDYRYEEMLKANKHFVYSDFRKINNIYCKCPKKNSCQHGGYYSKKDCNTCKCPAMFNGDNCEKLIETKIEGCNEGQTTLTALDDEQEVTIENIKEDCYISITATNSSKVVQIIVEWAQIFNIKGCVMNPRGEIKYRKDKGVEGLYIQHNVSESFELKALSSEVFVKFHDPFSKSSLVFFYRQVDQTEDFPDLTKTCKEKNTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ25</accession>
    <name>A0A0N5BJ25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ25"/>
    <dbReference type="WBParaSite" id="SPAL_0000595100.1">
        <property type="protein sequence ID" value="SPAL_0000595100.1"/>
        <property type="gene ID" value="SPAL_0000595100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000595100.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49782" checksum="E33AF53D007E9200" modified="2015-12-09" version="1">MSTFQCPNGYFISKFSSVFDGSERFYKFSCTKFGKEVILYDEICSTTEIETTQEGDMYLSCGSDQYTVGVELIENVHPGVHSWQLLCCKSNQILIRIDDCIDTKFINDYKRASSFSSGTQIIRKWQSMGESNDRRWWLQLCPIDILPSKIENINKDVRARRQVPIEWSRGRFPNTVSEYNPLFMEQEQLHESQRRKIFKTNQELNKENVLIFSREGLQTTSSPVNDGFPQMPIRLRHYSPTNINLNRLNILPKSTENPSTITTMSTTTSASTTQIPTTSKVYSNHQEKPTDALDYYDIYDDNFDKKKYLEKHNNGLLSAVSDIFQNLQDSLSLAQYAIPQEKFKLVLPEAPQPIIPSNYNGPPIKHNKPSPGNNEFLFSTDNDAFKFHINSDIKKPGPYPKIPNGIEGNIQRGNDNGQGPIDSILQTLGLCQNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJG5</accession>
    <name>A0A0N5BJG5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJG5"/>
    <dbReference type="WBParaSite" id="SPAL_0000609100.1">
        <property type="protein sequence ID" value="SPAL_0000609100.1"/>
        <property type="gene ID" value="SPAL_0000609100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF4">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894625" description="C2 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000609100.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33969" checksum="E81B8562163ED640" modified="2015-12-09" version="1">MYILIIFFTTFVSLTNSISQNHFWVVGEILSVQWKRGCLSAERCTNPRFQILSQQIDIEDIQRIDFPLHSTSTRNVIFNNYFPTGNPESLLMTIKIIGIDPLYNIPLDCDKSSNIRTFPIQNVNHSSTTEKTPSLIEFEGKCFTAIIQLKKYDTICPWCSEGRQLDEKDNKTISHTLALGEVKINQTTFIIILGFLLTVIFITTVSLSILLLRQRNKIKTKRRDVTICRYPQIPSTKIKIGVSNDEDYETIDDKEKLTSVYVKRNSCYSSGYQSSQTSATSIHSNHLVPQDYGSNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJJ9</accession>
    <name>A0A0N5BJJ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000612475.1">
        <property type="protein sequence ID" value="SPAL_0000612475.1"/>
        <property type="gene ID" value="SPAL_0000612475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000612475.1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3972" checksum="8C32938071CEFE83" modified="2015-12-09" version="1">LVKILLLFTLHQKNHQWLMLEQVLMVVNLYCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJW6</accession>
    <name>A0A0N5BJW6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJW6"/>
    <dbReference type="STRING" id="174720.A0A0N5BJW6"/>
    <dbReference type="WBParaSite" id="SPAL_0000623300.1">
        <property type="protein sequence ID" value="SPAL_0000623300.1"/>
        <property type="gene ID" value="SPAL_0000623300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904154">
        <property type="term" value="P:positive regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000015">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF6">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000623300.1"/>
        </source>
    </evidence>
    <sequence length="789" mass="89670" checksum="255A84C4A232A30E" modified="2015-12-09" version="1">MFNLCREKVRRMFYHAYNGYLDYSFPLDELKPISCTGMDTWGSFSLTLIDSLDTLLILGNYTEFERVVDLVLKTVDPDIDINASVFETNIRVVGGLISAHVLHGKVPNAKLPEGWPCKGPLLDLAVKFADKLLPAFNTDTGMPYGTVNLKYGVNKDETPITCTAGVGTFIIEFGSLSRLTGNDIYEKVAMNALNSLWESRSKIGLVGNHIDVMTGKWTATDAGIGAGIDSYYEYLAKGALLFQKPALMKQFKDSVNAINKYIRNEDWFLWVSMTQGTTTFPFFQSLEAFYPGLLALVGDVENAKSIMLNYNHILRQYGVPPEFYNLNKFEAHSGREGYPLRPEVVESLMYIYKATKDPTYLEMGASMVDTIEILAKTKCGYATIKDVRDGTIEDRMESFFLAETIKYFYLLFDKDNFIHNDGTESKIIATERGQCAIQAGGYIFNTEAHPVDPGVLYCCSRQKVEDMEILNSFSQNISFLKLMNIDDLSDWGEDEGDGVNEEESDQKNALSDELAELEALRKRSNLFENHKFSDIEYEVDGERKSVEEESTTEEETSNEEESKEEEESGEGFGISIEETKPSTKNTNSYINKEESNLVEEVNLEIKKMLVNYNKDKEASEKINDFIKRLKLLKQTYADIIEDSSNLYSRNLRETIKRKKKRREVSEIPQSQYLCFNCCWILDKPLDSFNFKAFLNEIYTKHLLPPGSYLPGPICLPNDPPYPSDKYFNDITELYDIPTFKQITNAIDGIDFTKFRYRSLLKENYELLSSPPPSFVSLLTGFGQVTTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJX9</accession>
    <name>A0A0N5BJX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJX9"/>
    <dbReference type="STRING" id="174720.A0A0N5BJX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000624600.1">
        <property type="protein sequence ID" value="SPAL_0000624600.1"/>
        <property type="gene ID" value="SPAL_0000624600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000624600.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56100" checksum="570DA481F05D73B0" modified="2015-12-09" version="1">MLKLNTLVRSSLKSVRNLNVPPPKLDFTPKYTKLFINNEFVDSHGGRTFETINPGNNKVITSVAEGDSLDVDFAVKAAKKAFDLGSEWRRMDASYRGVLLNRLADLMERDRTILATLESMDNGKPYPIAYIADLGLSIKCLRYYAGWADKNHGKTIPIDGDYFTYTRHEPVGVCGQISAWNFPLLLLTWKFGPALAMGNTMVFKAAEQTPLTALHFAALTKEAGFPDGVINVITGYGPTAGAALAKHHDVDKVAFTGSTEIGKIIMNDAANSNLKKVTLELGGKSPNIIFDDVDIDKAVDQAVHGVMFNMGQCCCAGTRTFVQASIYDKFVEKVKNKVEKLKVGSAFEEGVQHGPQIDNKQVETILRYVEAGKNEGARLVTGGSRINREGCFVEPTVFADVTNDMKIAQEEIFGPVFSIFKFDDEKDLVKKANDTIYGLAAGVMTNDINRALHVANNIRAGTVWVNCYDVFDAAAPFGGYKMSGIGRELGEYGLQAYSEVKTVTIKVPQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJZ1</accession>
    <name>A0A0N5BJZ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000625800.1">
        <property type="protein sequence ID" value="SPAL_0000625800.1"/>
        <property type="gene ID" value="SPAL_0000625800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000625800.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="19173" checksum="C22F24D1220C9DA3" modified="2015-12-09" version="1">MNALEKRQSIKKARKQLMTRREVYEISTNDGISFYNEQYNMNDNDAKMAKAALSNFKYLDNNKDEVLPFLEDEVSRTLLSMGRFKMVGPAKMCSDVLRFCGRILIQILTDRFNFYVKNCLTRKEWKKSIILFLHKKESKSDIYNFRPLSLTSHVYXVFVNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK31</accession>
    <name>A0A0N5BK31_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK31"/>
    <dbReference type="WBParaSite" id="SPAL_0000629600.1">
        <property type="protein sequence ID" value="SPAL_0000629600.1"/>
        <property type="gene ID" value="SPAL_0000629600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894414" evidence="3">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000629600.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51229" checksum="EDB7EDBD65310208" modified="2015-12-09" version="1">MVEKRIITYMAILCHIIFSIECSPISYKEKTCNKGTLYQCNCKSCWKEFEIRNETEKFLNWVQIELINCPNEQEIKTFDDLQIRKRIANWVNEECALVLDCNKIGITKRINEKDVIIGGSIECTPLGGQIKINVIGKGNHLTKENVVPPDTLIQILQAREHLLSYIIGIDLMSISTLSSNKVYPHQFGDLNGFHFDMFEDNNKNESEDDNYEDEDGYDDDGDEEEDYGQDGIHHHTQKINLDDDQTNNNNTLDNQTDLFMPSIDTTTSNNPIESTTKSYITSPSTQFTEEKEIVTTSTLLPSITTKAFIVSTTTSTIKTKLPNITLQPQLSPKIDEIPDDIINNNYDSKVYSNDKPSTTFTFNNISIEIPEWLTISLIVILTTLLLVLCVISCITYMFINCHSSVRKISKDKANKGLIIKKHEERNDVTRLEENSNVEKMLLEKVGTGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMA1</accession>
    <name>A0A0N5BMA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMA1"/>
    <dbReference type="WBParaSite" id="SPAL_0000704100.1">
        <property type="protein sequence ID" value="SPAL_0000704100.1"/>
        <property type="gene ID" value="SPAL_0000704100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894792" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="51"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000704100.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22911" checksum="1C09BFAC390B315E" modified="2015-12-09" version="1">MTKVLSTILFFYFFAKASSTTEWFGDLRAQYNPLPAREEPFYDVMYDDTVCPQGLKSKAIPEYVYFGAMVASFATNDKNDCLQSCVTNSKCKAANFFEPLKRKDKGFCELLSEDQYDNPRLLRPFKKATYYENVACRASADNNFSGISKAKAVIPVSRNEKRKHESILNALNSKDSKDYSLSMLKKIADKIHEFNSRFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMR6</accession>
    <name>A0A0N5BMR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANAPC4_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMR6"/>
    <dbReference type="STRING" id="174720.A0A0N5BMR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000720300.1">
        <property type="protein sequence ID" value="SPAL_0000720300.1"/>
        <property type="gene ID" value="SPAL_0000720300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="37"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000720300.1"/>
        </source>
    </evidence>
    <sequence length="845" mass="97035" checksum="9CFF06234838CFD4" modified="2015-12-09" version="1">MDQEIVDTESSGVVCRSTPFIEDSKSYKSSFPVYMAKWNPVHDSLVIASKKGDLCLRRGGYKKSWKVNIERIRGIYYEELGSLQKEFDMGTTLECIEWSPNGLYLAVAMTNGYLHILDYETGQVRYSQKFNFTITRMKWQWYIEYDAVKKFSQTFYESSQINVRFPNFYEEEESNRERFSGVMATKEFCTESVPKDLFGTILFIVTDKDLLIHALSCGIFPVAKFEAPFEQFGNFDSTSAVVNDINFDMSSRMLFVSYSGMAMAYPSYPPEIGVPEPEASEQSMGTNTHVVEFKIDFGSINSTVNIFLLACRWAHLYFSAIYIRSVFDYAISDWREQISTISNMFKASADDNNQVKNLSKELAKLIMFGASSPKAMYHFRFKIRPEGVRSIYDIIYTKFTALAKLINGPLKIGLLMVNDAHTRLSEETKSLGHNFLCERTNQLFKCHEDSVNIQALLRIVDDFQRDFEGERGSMLQLVRFMYSCQPVTSNFVVNKKKKVENTRILSTNYPLDYNCMVDYLVTDRIQPQHPESAFKKLLIDCGLPQYLDGDGIDEFIDTCFLQNYKQAKMNEYITLEKKNGNGKCDEELKFVDEMYCEIHGIDKELYREALKRNATIPGGIKTIFNILDKKTEAYLKNGIVEGKYCRFYNIEIAHPIEHDKFLIFPNGRMTKEFDIDGNVTRCSIDAQSTYVLHYLVFRKALGTASWNSLDSDGTVKVIRQIGTSDKISNEKSSDKDSQLTVITTGLEVRAKKSVVDCGINENRNIVGLIKLNESSNPDLNYPFIVDPNFGEVYIENNLDDYFVADQILIHKHFNIAGTISRDSNKIMCFNISSQKIEKVYKHFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPF0</accession>
    <name>A0A0N5BPF0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPF0"/>
    <dbReference type="STRING" id="174720.A0A0N5BPF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000777600.1">
        <property type="protein sequence ID" value="SPAL_0000777600.1"/>
        <property type="gene ID" value="SPAL_0000777600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007355482" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="18"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000777600.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="69391" checksum="EB4D9F6E12261C75" modified="2015-12-09" version="1">MFLYIFLGLSFILTSHSFYVPGVAPVQFRVGDPIEIKGIKLESTKTGLPYEYYSVPFCKPPKNKLHYKSENIGELMRGDRIVNTLYDVKMKRDIDCASVCQTSNIMSITTIDSSVLKKRIEEDYHVQLLIDNLPCATKFTDPETGEVFYDHGYRLDIVLKYHEPEPDVYRVVGFEVQPKSINHKSYSFSSPQQCTIDQSKGPQEVKDGKNSLYWTYSIKWEESDIPWASRWDSYLNMKDHNIHYFSILNSIIIVGCLAGFLSAIIVKTVRRDIATYNKNEEMEDTLEESGWKLVHGDVFRPPRHQMILVNFVGSGIQLIGMSGITVAFAMLGMLSPSSRGSLATAAISLFCLMGLIAGYHAGRLYKTLKGRNPKRCAFQTATLFPGIILCSGFILNFFLISKNSSGAIPFVSMLTLLFLWFGVDLPLVFLGFHFGYRKHPYHHPVRTNQIPRQVPDQPWYLKTIPSSLFAGILPFGAIFIELYFIFSAIWENQFYYLFGFLFVVFVIVFVVCCQIAVLVTYFLLCAENYHWWWKSFVISGGSAIYVMIYSVFYYYTKLNLIGFVPMVLYFSYSALIAFTVWIMTGSIGFYAAYYFLLRIYSAVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPK4</accession>
    <name>A0A0N5BPK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPK4"/>
    <dbReference type="WBParaSite" id="SPAL_0000782800.1">
        <property type="protein sequence ID" value="SPAL_0000782800.1"/>
        <property type="gene ID" value="SPAL_0000782800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000782800.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35001" checksum="25B12AEAD7AEEFE7" modified="2015-12-09" version="1">MSSSNSNMANEVVIKVIIKPNISFTDVSDSYLSQLKIEKTLSLDGKTLVNDLCKEIVEKCCLGHLVGHHQVFFQHSNLEYYPLHSYFPNMNAEIGSFCHLLEGILTVKILVPVESFGFIKMAKVDRVYDSLIKYLLSKMGDETSQSRDPLIQYITNVVKGCPIRQLPLETLIKVDEKLTHALQSSVRSMSEGVPQLPNKDNSLNLSSVPGNSIDNGGSSIPSLNEVDREEVPPGTIAKRRREIKFREEEVAFLEDWYELVEGARPDNCVLQVIADALNSISSRSEPNKIAGKNVFNWWKRRRNSEIESTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPW2</accession>
    <name>A0A0N5BPW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPW2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPW2"/>
    <dbReference type="ESTHER" id="strea-a0a0n5bpw2">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000793700.1">
        <property type="protein sequence ID" value="SPAL_0000793700.1"/>
        <property type="gene ID" value="SPAL_0000793700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="37"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000793700.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="66520" checksum="E1EBCE0050196C81" modified="2015-12-09" version="1">MINIFLLWFSIYFGYCFGSDFKYCLILLLTSLQKYAGKTVYEFLGVPYAKEPIGKRRFTPPLPFEKEDWDDEPYYNATYVRNGCYQNTRDFPLPGFNWTHPSSIAEHCLHVNIWKSASPNGGVLVVFFDVLHMRGSGTLDELNGGYLAAKTDLIVITVSYRLSIFGFGYLGEDGKYLTGNTGLLDQQMSLQWVYENIDKFGGDGKKITIAGFGSASTLATAHLFSTKSHKYFSSIFASSESITSMWSYNSREVAEKATRDVAYRVGCTNKTDYDIYKCLLKANPYKLAVAAEDLMFRGNFPFQYGFNVINYDNVFFNGNLITKIKNRKMKEDFIFFGSKSKYIGALYLAMFSDKYDFGFKTEGIFTNISYSSFKISYSQFKIFMSKINKHLGLKDYELKLIYEKYVDVKKIKKIKDFKSIIVKIVSDIYFNVGMEKFVYDLSYEHLSKKTYFYEFVRTSSGDRSRFPEWVLPRPGSEMEYFFGNPFTMSYKYNKKFIKLDQRVSYKMMMMMKSFVTTGKPGSKWYGFSTSSKNVFIVGDNNYCKDKSKKVSKTSVYTDKIKSLIQILPKEFNLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ56</accession>
    <name>A0A0N5BQ56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPW_WPC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ56"/>
    <dbReference type="WBParaSite" id="SPAL_0000802600.1">
        <property type="protein sequence ID" value="SPAL_0000802600.1"/>
        <property type="gene ID" value="SPAL_0000802600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105:SF0">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894957" evidence="3">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000802600.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24974" checksum="AC2FF587A3AE7D43" modified="2015-12-09" version="1">MHLYKTLLICFLLYHFNFIVNCHKNTNDHTTHLQKPYISVDVIDANENKKNNQNILNKPIVKRKFTEEDFRNMNNQYALEQSNEQIIKDLTEDVFDMSHPVYGGDRPSACEKRNSYFCPSRKNSHDDWKCIKLEDLCDSHPDCPNYEDENPTICMFHVLKIFEKRNDADWDKLPQLPQNRGRCFLNITGSKRIILNGVHYAIQLYLLFCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRB7</accession>
    <name>A0A0N5BRB7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRB7"/>
    <dbReference type="STRING" id="174720.A0A0N5BRB7"/>
    <dbReference type="WBParaSite" id="SPAL_0000841800.1">
        <property type="protein sequence ID" value="SPAL_0000841800.1"/>
        <property type="gene ID" value="SPAL_0000841800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001718">
        <property type="entry name" value="Elongation factor Tu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000841800.1"/>
        </source>
    </evidence>
    <sequence length="919" mass="104150" checksum="6771149E83D15697" modified="2015-12-09" version="1">MSIKINGELTFAEAFSKTGPENIRNVCIVAHVDHGKTSLADTLISSNGIISSRMAGKLRYMDSREDEQNRGITMKSSAISLYYNPIFINLIDSPGHVDFSSEVSSAIYIADISVLVVDVVEGVCSQTETVLRQAIQCRHDIILVINKIDRLICELGFDTSQAYKHIRMLIEHVNSCISQILQVYLLDDKWEEIDKEEERIHFDPVKGNVIFASATHGFGFGLEDFANLWTEKLNMSKDELKVLLFSDVYLGGGMKILNDAEAKGKKTLFEKLILDPMWEIYKCAFEKNDVDRLRELAGKMNITTKSKRTNEIYDEFMKQWMPLTKACVRAIYKCNSPKKCYENEDRLKNLLQVDCHPLSNDIKIADEESSRTILTIAKVFKFEDEKVGMCRVLSGRVTVGQKLYFLGDKNSRKNDSECEDDDDNELDSDEMSSVTITKLYIMMGKELVPVTSANTGQICGITIDNTFKSMTICSEFIKDGEICYNISHTEPLVHVSIMPTIPGNDEFEELKEALKLLTVFDSSVRVFEADNGELNLVTAGEVHLQKCIEDLKDLGQVNIDVSPPVVPFLETIIPETNLSYTKIVFNQMTECNIRGGMINIKLRSVPLPDEVCSIIQKNRSLLKKLREKKVESDDPKWMKFYNDFKSLCEEKLPGYKGTWWYKKSKEDVSKIVDKVWCFGPPKAMNNLLINNIEGDSNIQSNIWSASKTRSKWIDQAFTGGFDLTMTSGPLANEPLRGVAIIVEEFHMTEEEVDCSIQGQLISAVKGTIQASLKKHPLRLVAAMYRCLIQASPSVLGKVHTVISQRRAKTINEDINQTNGLFEIEAYMPVVESFSFCEDLRKKSSGMASATMEFSHWQIIDEDPFWIPTTEDEKEHYGDKGDSVNQAKVYMDNIRRRKGLLTDELIVVNAEKQRNLSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSM9</accession>
    <name>A0A0N5BSM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000887100.1">
        <property type="protein sequence ID" value="SPAL_0000887100.1"/>
        <property type="gene ID" value="SPAL_0000887100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000887100.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38526" checksum="819319C73524AF5D" modified="2015-12-09" version="1">MDKSSKNPLQDSFLNRSAKRYVHSIFGESVNFFWFFGQIHVKWIFVWAQLFLIFISVNLLLDCSAGNYTQCSPVWRNLFTVSDFLPTSNENLDRTVFEQNYYYLRAVAAFTFVLNCSCALFAMAGLFSAEKVYNKKERRSNSFNVHPLVFAIPSYFCQGMWIFIYFYWTLTNIKKHWDAVTFLYSRFFFISIIPYSGVWVMIIYCFCGSLMAIKFILRAARHREVDPELTITMNNTLYSRRGYYGDISLRSGKSDCSGGSVSARSIKNRRVFRSGRYRLPNPGDATHKRSPNKSLLTKVRHTGTKKHDISVRSNRTEKNLEIIQEEEASNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT94</accession>
    <name>A0A0N5BT94_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="SPAL_0000908100.1">
        <property type="protein sequence ID" value="SPAL_0000908100.1"/>
        <property type="gene ID" value="SPAL_0000908100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="207"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1437"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1482"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000908100.1"/>
        </source>
    </evidence>
    <sequence length="3858" mass="441064" checksum="E0E135795CEB6F3C" modified="2015-12-09" version="1">MNLYGKAGSILRQISKVPEFVSYRKTSSVMTLKTEDEKNMASGTKGITFYGASTTPNMGPIQSLIKKKMITKTENIYLNLFVLEDEMEKKSNDKKEVYMRDRIRAILSKNTNIAKDKVEKKKFSTGAKNFLSTVCSAVLTSTNGVNIKVGYKPFSYLEFLNFQKPGSIKNTVTFDDVKGMDEAKAELMEIVEYLREPEKYERLGAKLPKGVLLAGPPGTGKTLLARAVAGEANIPFFHKSGSEFGEISVGQGVKRLRDLFKEARCKAPCIIFIDEIDSIGSKRVSNSIDPSANQTINQLLTEMDGFDNSEGIIVIGATNRPEDLDKALIRPGRFDIHVNCSIPDLSGRIEIFKHYLGKIKHRNIDIEVLAKTTIGFSAADISNVVNQAALKAATEGCHHIMQKHIEDAIDRVITGPVRTKGKHPKKESNRNTAYHEAGHTSATLNTPYTTPLHKVTTIPRLGSLGHTCFIPEKDKCHTTKAEILAQINVMMGDRVAEEFIFGKDFKTIGASNDLKKSTSSTKIHTKEFCMGGNIGSRKYKSDICQKSDGKDVSPQATNKAGLKIDKIMNKSYARENSNLTKNEKDHKRSAQGFLKNRKFTAEEVQSIPNGKPPGRKPTKGPFGEMLEGYLASVLNRYVGEYLEDLNTDQLSIALLSGKVELENVPLKRSALSKFDIPIDVKSGVVGKLIVTIPITAIRSEPWIVKLNDVFIILKSSERQYLGKEQDETEIRRKEELFKELEEIHKKILLKRTNLFSGENDKQSQWWGNSIISSIINNIRLIITNIHIRYEDNKTISQDVIFSCGLKIKSINLHTTNDQWEEHYINGSNNLYTYKKLDIDGASFYWNTNETKLSEVETLDDLKNSFLNNNFNDSCYIIQPFELQIKLTKNTSKLNLTEETKPRFQLNVFPKKLAIDITVRQLIQMRALANEFKRFDRARKYRKWRPKEKVSGNSIMWWKFAIDRVIDSIKRKNITNTWDYAISNARDEIKKRKKHEVFKYFDLLNEFMDSQECEKEVIYMKQVERDNQMTYSILNITRDHVCKKIIAEVETYFALQKLDIDMLSTNTVFDVSNYNGVIDIPIEVDNEEKSSTLYKWVVSWFSNDESGVGESIELEEDQCIETDVKFPVFRSCKLPANFKKVENKMEKDLLESLNEMLDDSTIFVRDKILAVVNLNVESITFRILIENYKSSEYNCVSIDLSKVLIDVQLSAREHRTTLLLDVEDFNIRCTKTNKLESYDASKSISDIFDEAFLNKAAQVIFTVEQSKTNIEKYGDTKSNQSAISMFYSRFSPKTTVFHKLNAEFVPFTFVLDESSTEDLLNIFNLFNNYSENFDSSTNQTEDSFCNQVNLIYCHLKVPTIDVVLKTRRKFLFGQSFNTEESQLFGAITFDDVSFGVSKMEEYLTKYNISIKSLCFLDFYEKKFSKLLEIKNYRDKISTRSRSNSFPGNMSSSIKPRRKSSSFSDEHSITMCNGDLNGNQQNKSSEEFPMHTDKNDSEESDDNHFIVAIDHVHKNHHQFVSHYKEVEYNFGIQASYLDIGMNQHTWVVFQDIIGLIPENPHKHDFNSEDDLELQELLLQGLHELDPSFNLDKYQMDSKQCSRNDRLNHSKKILSVPLNVLLGMSFQEVKISMNLPQKELCLGVIHLNNAKCDIKFDINNEEIPMEVYLAVESLKIDNSIPDYNSLYQEALSVEKRNASNGNDSPIKVKILKYRSFDFDLERPYDAKMDIVIDESFEVTYLHLHRFFCLTTDFWVNYVDLIDKMSKKGVAGISDNANENLLTRVSVEANINCPVSVIVPLNQFSSRCIIMKMTKVEATNKFDLASQSKYMNDYVINRNITQDNYDCLFDNMDLLVEDLEIFEGESILVNSKKFSNCEIFLDGLNGIAFKSDLKSVLSKKKSAKIIFGRNLSCFISQNAPNINVIVIFENMDIILTTKFYKLLQGVLQYNLGDYTELDTNSALSENGMNSLSNISEDHLKQNINLSFRMQFTNVDIKLLTPSKSDNYWDNLGIVSCGNAILGSDSYVDCQFEISFIVYHAQLIDKRIDLSGNNLSEEVFSKVLLPKNDFDSSVRQAFLEMNVFFKNNDAPVVTFVLQETQLLVIPDWFLALKEFLLLESDFDVNSEEILCNIPILKDYFKKNVDNSKHENSLNTYEIKHSITMKTQFTDCDIVFIENLSDPKSLALKCFVTSVLQLNDKMGYLSAEFIIQKIQVSWFIFAEESNTNCIISTPFNIEIKLGAVANDISFSKPHYSQKQEITKHYITIKMDNCSFRLSYKDVLVAMNVINGCKRLLDTNLYQLHWAPVLKDEPTAFNTIKIKNINCAITDFSLWILNDFNGPTLPIMRLSSVKWKFVFTEEKFISEGILSIEYFNQRLSGWEPFLEPVEISSFNLEYHDRKSIYSEFKVNPKSHIDINVTTHLIQQLKAFSNEFLNIKSSIDSNFRSLCRKGRNNNTSYIIKNKLGSNINFTTEIDKLLQKDGKYRQNVKWSCVEAEKEIEFFLPVDRNHLYGSDYNSYSRLILSIDGYEELQPINIDTVRTYSINARKNVNSLTSKRLKYVKLLINISISDDGRKAIDVRTAYSITNFLNIPVMLKIDNSVNGSKEWIDVKISPNEDYYIPLKYIYSRIYCRPIFGGKNSLPLTTSDFSEVIFNDEYYKQNEPSSFSRFTQNDKKLYFMLYNHIDGKISNKTIPGLNISIYPPLFIRNQLPTDIDFGINGQNIFCQSGNTISLPNINVDEPVALDITTDRLKSVESLELSRSSILKLQTRYSKPIPITMVDEEKRKMIIYADISLSRNGSIIIVLWVTYWIVNKSGIPLIIRKNESFEDIAGQLLEHEQGNDKIPLMVSFNNDDEEVKRCNLRVGKSFLPDKNYFPEYSEPFKLTPGEQSLALHMKHQNKPTLIYNVGIEVRQGTGRYKNTQVVIFSPRYLLINRSSYTIYLSHIDDITFKRYNIIEPNSNLIWNESFEDNGMICIKRSDVKYWSQPFRIDQVGSYFITMRDIDETPNFVRAETTLSNARFCITFSNTEFYPPPIQIINESSIPVLYQQVSNHPVPSYLRSICKGSTKIDYAWDFIYGQKLLSLQASSYSSHSYDPTKSTVGPSLYYENYSFIFLDSSISGLIRSNTFNNLIEGLVLTVVDSNYVKLMPIDKSGTNLNQLWNFTSEGTIESVALNNYHPNSSTNFVLDLLSTEREFILVVGLRDKTRNKTQLWKFNDDGRFSCGLSNGYLMKSIQNYLTMGFSRNINTLVCSFKRIYQKEGTGILNVQCSHVGPTLVVRISFPDTIQPRESSVSSSSDQKIELNILIPNGIGISLINAAHEELFYGRLKDNQLNGAQNFNFFFCQSTEEKERLSKINENLSQDQEMMLYLTSSAMKIELNYTRKEHYDSFEYFKILFSNISINLDEQLLWKFIEFIQESGTAESVAQINLLQPPNIDLDDVNKISMRRCYFGNLILNIGQISLSVITIPTNVMEKKIQQIKQNFNIRLMSFENASITLPPFIQTHTFETITFLIECLKKFYINELYTQTFNIIVSLDAFGNPLGLATDIKDSFQTLIFDGNVSGFVSGFSYGVANSFSKVMSSMATGVGALITDKEYELKRRKSIKVSQNSNDKNPLTHLYSGFKGLGTGVIGGATAIVGNTMKETRNKGLIVGLVKGVSTGVVDTVAKPVQGVFDFIGGTATAMKEVAGNSHVKKQCIPRERLRLTRVCNNLCGLLQPYKVEYALAQQLISTKFTNFSSKSVLLEIEVYHEQKINNECVQLCALICTDKAYFLQKNNGNYTEIINILDFKNLSNSPLIPKRIEKVDENVKYTVIVASEFDSKINKENTIQIMVYSYEKAQILCDKLNRAKELYDRASKNISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTE9</accession>
    <name>A0A0N5BTE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase_Zc3h12a domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000913100.1">
        <property type="protein sequence ID" value="SPAL_0000913100.1"/>
        <property type="gene ID" value="SPAL_0000913100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE REGE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase NYN" evidence="1">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000913100.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41528" checksum="D7EE41B1ADCDCD28" modified="2015-12-09" version="1">MENNQSDSTEFYQQQVQRKLCRVLKNEYLFNSTCLEALPRVVVLDSCSFSKNSGISNKENINCAGLLTAIRYFLVRDIDVAVFMPVTYLNNENTTVSDVKLLMELRKFDIITFTPSRVTHLERPAFLNYDNLYVLHAAKRFGGMIVSSDRFTDILQKQQYTQYHNIIKHRRLDLQFIPVGRSIVRCGKDIFYKCLPNIELPTDYADYYQIKKKNPMFCMPFDEDYEKVAFRGRFWNKSRRLEIIRAIDGMLKNIESRCCIYDFAPSHTYKYPSLNYSLLTNINELSKKKQCLHDTQLISKSIGCSYNSQQPPQDKMSMIFKTKSIGDYNLEKPIVSSLYKSYAQKSVLDNVQYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTS8</accession>
    <name>A0A0N5BTS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000925300.1">
        <property type="protein sequence ID" value="SPAL_0000925300.1"/>
        <property type="gene ID" value="SPAL_0000925300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894845" evidence="1">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="178"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000925300.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="38313" checksum="F3661B1D04735F91" modified="2015-12-09" version="1">MHFLLVSLLYTNLIVNIVGGQVENSEQNIHKGEYGTYSLAHNRRNYRGEYTITEIRLRTGVLYQCNGTNYKQSNEALECLRRLQGQYPRVIYVFPPSILIPKPTPPPVHPQRKINPSLFPTLLPKPQKPLVIESPRLHIFKQFDIKKYLSRSHFSKSIYKRVWSGCDYRNYHRNYYKHFKDKVLLQINLLRKYHRVGPLKENYYLDLYAQDLANRMAKIGSEFYIASSVYGIAVEGMYYPAASTIVTHWYDEHLHYKFGSNRPVYRAQRLTQMLWKKTQYIGIGVAVRSKYLFLACYFYEKGNINGEFKKNVLDKRFWHRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU48</accession>
    <name>A0A0N5BU48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU48"/>
    <dbReference type="WBParaSite" id="SPAL_0000937100.1">
        <property type="protein sequence ID" value="SPAL_0000937100.1"/>
        <property type="gene ID" value="SPAL_0000937100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000937100.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9828" checksum="4ABA51135309BA80" modified="2015-12-09" version="1">MYFIIRYHNVNEYYPLIYTRPIGYFFCLIIGYLLCDTTELIANECSLRVIILVIHHLLFGMGCLYPLIIQKYGGLVVIRLFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV29</accession>
    <name>A0A0N5BV29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E2F-associated phosphoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV29"/>
    <dbReference type="STRING" id="174720.A0A0N5BV29"/>
    <dbReference type="WBParaSite" id="SPAL_0000969500.1">
        <property type="protein sequence ID" value="SPAL_0000969500.1"/>
        <property type="gene ID" value="SPAL_0000969500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000969500.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20222" checksum="162A49544D070EB7" modified="2015-12-09" version="1">MSGENPLIDDIKSIAKTSAESDFDFYCALEDDLNQKWVDDKLRKQKGLNSEEANEGENKDLDGLNGEYTDCDFKTDAVLSCPSCLTVVCYECQRHESYKNQYRAMFAQSVKVDFDKKLYIPVNSKMHSTELVSVIPENAKTDDIFYPVYCAHCKHRIGVYDNEEVYHFFEVITGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVM3</accession>
    <name>A0A0N5BVM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000987900.1">
        <property type="protein sequence ID" value="SPAL_0000987900.1"/>
        <property type="gene ID" value="SPAL_0000987900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="525"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000987900.1"/>
        </source>
    </evidence>
    <sequence length="812" mass="91527" checksum="0D9375C5246E105F" modified="2015-12-09" version="1">MSAPVSIINQKIDNDMPCTTNYSKDPSVVKNANISSGDNNTTPITTKSKTKIAFSSTLLNTFSQKSIQHSTNISYAKDTCKTKNVDENLLTIDKNNRVTLKNYTHKSELNTDLTMTNNSPKITSNELHKEYQYISKNDNFLRNTKSLHAIAEAVESTNLNPASSLIVSNPAKTLPISKSTTFQFFTPSPDVIPNRPSPFTKSETNIKIQQKSFNTTPNSMGKLMNFRAPHSIPHVWVSKRYPTICSDTCEGCQKTLGFVSSWEKCKSCKKKAHTECKRRIGNNCGLTLEIFKAVFKELHITQGQERWDSYRTSGGESSSSTNSTAPSTPAPNLINSVIPKQSGQGTSSITLSNITSEHFTFQDPTSFSQTFPRSQTTEPSILPTNHHVPSIILTDTNISGESTNKTGPLKSSLSTNEISSEEDKFLSTNNVSNLMKKDIPIITTTSATLTSTNDSEKTLKGVTFEDMSSLEGLNFGGDENSDRQGIYYRLSFKTASMREKNQKKGKKVYENIPEDAESNINSDAIEVLELIGYGRFGEVRRGHYFGDVSIKLLNMDHVPEAKQYETFLLEADSFLKVRHENIVLFLGYTYEQGNLGIVMSDCKGKTLYQLIHESLPTECLEFSQIINFSLQICQGMTYLHTKGILHKDLRTKNIFIEKNNRIVITDFGLFNMARLRHPPRKNGFFVSENWLCYLAPELIRVITPSAKPIRFTEKSDVYAFGTCCFEMFFGRFPFSECNWEVKMFFIGQGMKAPFCGNEVSREMKNILMNCWNYNPSNRPAFEDIFGNFGKLPKKKIMRSPSFPIQRSYESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVX1</accession>
    <name>A0A0N5BVX1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVX1"/>
    <dbReference type="WBParaSite" id="SPAL_0000997700.1">
        <property type="protein sequence ID" value="SPAL_0000997700.1"/>
        <property type="gene ID" value="SPAL_0000997700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895007" evidence="5">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000997700.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15485" checksum="96D02484BBA579FA" modified="2015-12-09" version="1">MYLLILFFLLINFYTLEGRYQYITVTGRFLCKGEPLKYIDVELKDDDLLDWELITTGITDYKGVFTISGKHEEFLPLRPYVEVLVACCKYEDEDFCEFNFFKKFVPFYKVTYFGSKTFYDFGDIEVAQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWJ1</accession>
    <name>A0A0N5BWJ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BWJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001018500.1">
        <property type="protein sequence ID" value="SPAL_0001018500.1"/>
        <property type="gene ID" value="SPAL_0001018500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001018500.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35024" checksum="0D17DC65990A3F41" modified="2015-12-09" version="1">MDQFGSSGSPQAPLSVFEPMSNFTATAQTPASTSHHNNVSNEPSSIIGPGSVFSSSVITGLGSMGPGSAVGPGSVFPFNGPASVLSSKLDQDKNPLSAAPASNRLDLPKTPMPIANNDFSIESSKILPPQSNIAMTVIGQSHSSIEVDVPLPTLQNIVSTVNLGVSLDLKKVAQSARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEDSSRLAARKYARIIQKLGFNAKFTEFKVQNMVGSCDVKFPIRLEGLCVAHAQFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKFKKDIDEAFKQIYPLLKNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWT6</accession>
    <name>A0A0N5BWT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWT6"/>
    <dbReference type="WBParaSite" id="SPAL_0001027600.1">
        <property type="protein sequence ID" value="SPAL_0001027600.1"/>
        <property type="gene ID" value="SPAL_0001027600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001027600.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8564" checksum="E82FDEFA6244836D" modified="2015-12-09" version="1">MTSDYCLGGKEYYLKMLGRNRLLRELMNDGISKITPTGDVKKIVTSIIKRYDLLKDISKDDKEDKEMFPMDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWZ2</accession>
    <name>A0A0N5BWZ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIT_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWZ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWZ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001033000.1">
        <property type="protein sequence ID" value="SPAL_0001033000.1"/>
        <property type="gene ID" value="SPAL_0001033000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MITD1 C-terminal phospholipase D-like" evidence="1">
        <location>
            <begin position="95"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001033000.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26579" checksum="479A79A20ADEC57F" modified="2015-12-09" version="1">MPDEIDEYILDARKFIIQGKGFEDDGKAKDASDVYLQACLTLQKALKELSQNDQRRKPITNVLSEYTDKIEKLRGCFISSKILNETVEINEDDTGYSFSKIFGRCIDDNITAVRIEDPYIKSKSQTINFTAFCEFLVKSAKNLKMISLKTGSSDCNDMLQNLKGSLNEKNIVLEINFGDFHDRLIRFNNGWEVDLGRGLDIYKYSPPGAIGFTDFSFRKCKKCRIRIFKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWZ3</accession>
    <name>A0A0N5BWZ3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein transferase MAEA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Macrophage erythroblast attacher</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWZ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BWZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001033100.1">
        <property type="protein sequence ID" value="SPAL_0001033100.1"/>
        <property type="gene ID" value="SPAL_0001033100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0265">Erythrocyte maturation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="299"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001033100.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44017" checksum="6CFD9A94CC025A68" modified="2015-12-09" version="1">MERLTETTCLETHLIKGIFETFNKHYRLNQKNIERMAIRIREPLKVCRKAMDDGDLEKAKRALALLKSRIETLSEEMTDNWIKEQELIKNFRERWLYINKVDIDEQRFTQQKFHRYLTEHLLRIGALKTAKKYAEKYNVENFANFESYSEIENVISSIDQKNLEPAIAWCAQHKSRLKKINSSLTIELKIQDALSNLQPNNKLEVLDALKKVLNENNYECSNSKISEIIGAIIVAGGCNIQKYNDMVNVKRYVQLRKLFITDASKIYGFYGGTPFSISLLLGICAYKSSKCSEQKDSKCITCRPLYVKLGKKLPTASRRNSIILDPITKEILNENNVPMMLPNGLVYGKKQIDKNSKDGEFFCQISNASFPVDACLRVYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXS5</accession>
    <name>A0A0N5BXS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BXS5"/>
    <dbReference type="WBParaSite" id="SPAL_0001059400.1">
        <property type="protein sequence ID" value="SPAL_0001059400.1"/>
        <property type="gene ID" value="SPAL_0001059400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="486"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001059400.1"/>
        </source>
    </evidence>
    <sequence length="1349" mass="154081" checksum="2BFFFB9B068648C4" modified="2015-12-09" version="1">MLRKNRFNGNDADDSDLDSNDELNQHYKIKPPIKRSSTASPGCKNRQKYYYRRRSDVPSVSNSYSYLTGKKNYRRKSSIERSSKSLNKSKSNLRKTNSEPNVEQVQNNQINLIKNLLDTLSIPIIRHQSTSAHDIWMTPRQSLVPDDYMSVTEDEYINTEIKELREAAESIQSLQRSLKLPISRTSDISLENSETFDDGVSGDSSKKFYKDNSLNLPTSTTSITTTHYGLHPRGVMQFLPSVKPNSLSPRMDTYRFNRNGAKFSIDSSSTDTSSNNETNSRSNSNNKLTPDSRTQSIISDGFIKFENDSISYNYTPKDLTENNSSISLPSFKNNEEIYFNSSNIKIYRTNEEGEMFQSTHTECGELYDSDKGANSIASVSRFSDLLKSFKNKDLLKDETLDDEINEDWDKSSTKFSNTSSYDISSLLPPLNKISMYGSQTLHPNLLQLPTINTSHSTPKLDQTLLQADKILWKKRSRASLRRHQDVRILAIRELFETEKSYVESLDYIVQKFMRPLKQPMEGAVIDSETIDKIFYKIPEILAHHQVLLAALYSRIKCVANGDYIIADVLMAHFKKVSMIETYIAFVNNFKAAKQAIHDARQKPSFDKFYRNFCKKNHSKLDLDSILILPIQKIPRYELLLKQIIKHTSVEHFEYEKLMLVKHYVHELAVKINKQRDDNDYETQNLLRYDLVALSTQNNDVKKGRCIFMTSDQMIIASFKNKANNNCFIPNYGKNIKNLFNIQHSNFLNENKFKLLMKISLNDVDICRDTLTLLNEVKKELKIVQEDSSILNKMMDLSKLLECPSKKELSLLIEECYLEKLKQKKNLEERMQFDSDLTSVDLQILTFDGIEKLNIQFGNADKRATWEKNLVESKKALINDSNINFEPPEFVTSLPLKLRNGLDLSVATPTFEKSIEGASNLWIASTDKFSGQISTININGVPTVESSTFIGNSTIVSIISVPAPKIRNNRKNRVRNLSSNFEKSIENAKKTSELLIDSSSSGESELYDSESTSISILAQQSTIWIGNEDGEIFVFNYHDNIKNKYKEKTIKLQIPIIAMVYVEDNIFVSCSSKYQNQFIYFERKKDMTWDLQKRNILKDICNSKIDCMIAVGKRLCFSSENYIYLLLNGNVKKIEKKTRIGCNSDETISYMSIQGSNLFLGMTKSPNVKLLNAFTFELITEFSISPIINKTLSVVENIIRQHKMGCLKITSMTCAKGQLFIGTSAGIILSTNVNFSKNNFIPNFNVCDIAHAGSCNFLICANISTFDLLKFPTKSRRMSLNASLLERIEEIYLVSGGKGIDMTYYNTNISGNQNDIISKLNNFSDGNRPSQLISNTENMDAINHLLFWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXT6</accession>
    <name>A0A0N5BXT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXT6"/>
    <dbReference type="WBParaSite" id="SPAL_0001060400.1">
        <property type="protein sequence ID" value="SPAL_0001060400.1"/>
        <property type="gene ID" value="SPAL_0001060400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001060400.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24792" checksum="65D3B135F5EADD51" modified="2015-12-09" version="1">MIKEDKIRVDYQKKLLEESEKLSEPAKEVFRKIETVKANMDITKKEEKKIISRILSKASPAIKQELKRILPKKDDFYRQQINKTNDKTYGIDPDLVQKYLDIKRKSNKTKLEIKNEQAKFIEEQDEETQKKFRDHLQEVDARNEAKQKTELELYEKLSPQAKEVYDKILAVRGNDELSYKEEKKEIKDIINQAPKNVKNELKVFKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXV7</accession>
    <name>A0A0N5BXV7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXV7"/>
    <dbReference type="WBParaSite" id="SPAL_0001062125.1">
        <property type="protein sequence ID" value="SPAL_0001062125.1"/>
        <property type="gene ID" value="SPAL_0001062125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001062125.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14878" checksum="98F6B3FA92912B24" modified="2015-12-09" version="1">MRLTPWIQAKEVVKINNDTIQAGEVVNFNNDNIQEENTSVVDVLPDHLKKAMFNSLYLWLKDIVAIAAVILFVLFIIRYCRRSEKIRKVFKFFFTDKRKAKHNVHEKLRNRDIEENQVSTNEQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY73</accession>
    <name>A0A0N5BY73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 10 (Fucosyltransferase) C-term</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY73"/>
    <dbReference type="WBParaSite" id="SPAL_0001073400.1">
        <property type="protein sequence ID" value="SPAL_0001073400.1"/>
        <property type="gene ID" value="SPAL_0001073400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001073400.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="41028" checksum="7C7C9F6ABF84BE65" modified="2015-12-09" version="1">MVTASKDIHFYNFRNNITTTDNSIKDTLQPHQIAIVTVIDGAVEYKYKQAIATVKCYSWHHNYTFAILNTQELPEFTYNCNQPEFFFRRHCIVANYAQSTIDADIMVVNPVHRIENYLPKGEEDILFYDRTHNSEIMAGSYIIKNTLYTRNFLKIFADYQYKKPKKNFFGDNVALHAVFAEFIGIVEHHNKYLRCMEIYNSIGNGLEENMLFVSCMRYILNLIDETPNDINYHTYEGGKIKIVRKLSKKRWSRDSWLSDYTFCDDELFHHGLKEKKIELRKNLFKRKFLADEKICKNSDFLKLWDCDKSFKTDCKTINDKLKVQVDRAHDKHMKYIKESNVTKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYJ2</accession>
    <name>A0A0N5BYJ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BYJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001084600.1">
        <property type="protein sequence ID" value="SPAL_0001084600.1"/>
        <property type="gene ID" value="SPAL_0001084600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="87"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="401"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001084600.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63232" checksum="320F4357B31A0CF6" modified="2015-12-09" version="1">MVGEVKIHKKNNSANQRELLNKSIYDIVNHLVQAHKNNKDVNLNRLKCDVARKYGLSSQPKLVDIIAAVPPEYRDVLVPKLKAKPIRTASGIAVVAVMCKPHRCPHINFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPFLQTRNRLTQLAQLGHSIDKVEFIVMGGTFMSLPDDYRDYFIRNLHDALSGHTSSNVEEAVYFSERNKIKCIGITIETRPDYCLPRHLNDMLSYGCTRLEIGVQSTYEDVARDTNRGHTVESVCETFHMSKDTGYKVVIHMMPDLPNVGYERDVEQFIELFENPAFRPDGLKLYPTLVIRGTGLYELWRTGRYQSYPPQMLVDLVAHILSLVPPWTRVYRVQRDIPMPLVSSGVEYGNLREHALARMKQLGTVCRDVRTREVGIQEIHSKIKPYQIELIRRDYFANGGWETFISYEDVEQDILIGLLRLRKCTDKVHRNELMDGCSIVRELHVYGSVVPVSSKDPTKFQHQGFGTLLMEEAERIAREEHLSKKLAVISGVGTRNYYRKLGYELDGPYMSKMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD1</accession>
    <name>A0A0N5BZD1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZD1"/>
    <dbReference type="WBParaSite" id="SPAL_0001112300.1">
        <property type="protein sequence ID" value="SPAL_0001112300.1"/>
        <property type="gene ID" value="SPAL_0001112300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001112300.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15609" checksum="2FBA7F32DD557D36" modified="2015-12-09" version="1">MIQYLDVLIILVLPFLSTFINYKIYVNATRTTSISNTLHVNENKILFKGIAIQSIFPFISQVPAISYILYYSATRNQVIVAEITLSSFYCIGNGFCIFLSLVIIKEFRNMMINDFRGTKIAVPIPNTVRTNRIKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZW1</accession>
    <name>A0A0N5BZW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZW1"/>
    <dbReference type="STRING" id="174720.A0A0N5BZW1"/>
    <dbReference type="WBParaSite" id="SPAL_0001129900.1">
        <property type="protein sequence ID" value="SPAL_0001129900.1"/>
        <property type="gene ID" value="SPAL_0001129900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF9">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="156"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001129900.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54325" checksum="1A0199E909C3426B" modified="2015-12-09" version="1">MAITSTIKFIPGNISEENFDTTNMEPGSLIFNAQFESGNLARVDVINKNEYDLFIRPDTYNDRQRLWFNFEVRNALPNQKVIFNFRNLSKKNILLKKGLASPVVKEPGTNTWKRFKSSKLFYTENISTANPNVTTNVLTIYYQFKNENTYQFAYCIPYTYTKLQKYLFDNEKAFSNIFRKQVIGKTIYKNNLDLITITNNVNSVQKKQKIIFITARVHPGETPSSYAMHGLIEFLCSNDSQANELRNNFVFKIIPMLNPDGVILGNYRSDCLGQDLNREYIEPSNWSSSTIYCVKNLVTQYANDPNIELQFCIDIHSHSQKTNSFCIGNIISKDSKNCDYQLIFPYMMAEGSSEYSLSNTVFDMEDKKEGTFRRVLASIVPDTCFVYTYEISYFSYNELDEGDASGCINYTQSDFENCGKNICMAILRYSEYKSHKRNINIDRSFESFLSNRALNDFKKLGRMNVRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C096</accession>
    <name>A0A0N5C096_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C096"/>
    <dbReference type="WBParaSite" id="SPAL_0001142600.1">
        <property type="protein sequence ID" value="SPAL_0001142600.1"/>
        <property type="gene ID" value="SPAL_0001142600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001142600.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14169" checksum="8EEC72DC8B268D9E" modified="2015-12-09" version="1">MSKFRNDTNQVLSEAALTERSVVKERNMLSRRLSECESILENHEKVFCQKFRRQLANKYCEIVTDLQQGNVKPPRMETGRSKVPSRYAETYLGELCGEPLSRVGMSSSKGNEGEKSYVRYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0L2</accession>
    <name>A0A0N5C0L2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0L2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0L2"/>
    <dbReference type="WBParaSite" id="SPAL_0001154000.1">
        <property type="protein sequence ID" value="SPAL_0001154000.1"/>
        <property type="gene ID" value="SPAL_0001154000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF25">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895144" evidence="7">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="8">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001154000.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20389" checksum="690CEF166B355171" modified="2015-12-09" version="1">MLKVLILCFSLLWCIKFGYSCSCAPITVEESWCQADWISYVQIIKTSYNKMSNQSEIGQDLYGIKYTVKHLETFKKPSKKKLSNIIYTASVSSLCGITDLSKGYKLYLSGFIEKKKRLTINICTSLLFNYDQNGSVLESDIKALKNKSYKTCKKEKKSGVSKRGQNISNIQKKNLTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C135</accession>
    <name>A0A0N5C135_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C135"/>
    <dbReference type="WBParaSite" id="SPAL_0001171300.1">
        <property type="protein sequence ID" value="SPAL_0001171300.1"/>
        <property type="gene ID" value="SPAL_0001171300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001171300.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="41611" checksum="2433AA3730D3B07F" modified="2015-12-09" version="1">MIFSKFYNTDNCTKQIEHFKVNHEDYGKRYAIIAVVDSIPPGKYKFATDTVHCYSHAFNYTYVTVEMKNEPEIGKMCKQSDIMFVRHCFLAEYLELHKEIDYVLFVDADTAVINPYHSLVEFAPRGNEEFLLYSRIFNYEIACGSFFFKNSNYSRTFLRDFANFYYKVPKSMYGRDNAAIQALFLEKFEKTRFLDERKICYEVWNKSQNWDDIWDFEACMMCLLEKASETPISTKLMTFDNGKVVVVGKESERRWIRDGHITNHLFCKKDFLLHGYKDLQSAMPYVGIDEFVFNHEECSNRSLANLWSFKNNSFVECSYRDELIGKRVTQVRNEFMRDLNDSGYFRKYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C212</accession>
    <name>A0A0N5C212_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C212"/>
    <dbReference type="WBParaSite" id="SPAL_0001202900.1">
        <property type="protein sequence ID" value="SPAL_0001202900.1"/>
        <property type="gene ID" value="SPAL_0001202900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001202900.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18497" checksum="3B15D017878A13A9" modified="2015-12-09" version="1">MITRSQSKNSNVPDILSDEFKQISCDLKKWKNLYNELEKNFEDLESDYRAAQNQITHLKNEATINKNKIKILKDEKIYLENALNNLEKMIEEKDEKIIELKKDVSMLRTVKDDEKENLNEINLADELKCLDIGKPKLSSTPVNFIFMYILEKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C215</accession>
    <name>A0A0N5C215_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposable element Tc3 transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C215"/>
    <dbReference type="STRING" id="174720.A0A0N5C215"/>
    <dbReference type="WBParaSite" id="SPAL_0001203000.1">
        <property type="protein sequence ID" value="SPAL_0001203000.1"/>
        <property type="gene ID" value="SPAL_0001203000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001203000.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18577" checksum="243026087D5577E0" modified="2015-12-09" version="1">MIESGPPPNPIHPCHDLPIFFEGSLDSSRYIDEVIEIFMAEMKKDNENISYIVFQQDGASCHAFIETMSHLKSIFGRTNSVSRNSDLKWPARSPDLNPLDFYLWRRLKDLVSKNRSETIEILKTQITDAIRNISVDELERVYISFVSRLVRCIEAGCGYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C223</accession>
    <name>A0A0N5C223_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C223"/>
    <dbReference type="STRING" id="174720.A0A0N5C223"/>
    <dbReference type="WBParaSite" id="SPAL_0001203700.1">
        <property type="protein sequence ID" value="SPAL_0001203700.1"/>
        <property type="gene ID" value="SPAL_0001203700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001203700.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="63508" checksum="31C447A334AD72E6" modified="2015-12-09" version="1">MIGIGECILLSITLFIIISTLFSKYVAIGLIVILTSLIIWKINSCSHYWKKRNILGPEGKFGVGNLLEIMNDFKNCDLKWKKEFGETYGVMMGLRPDLTTTNLDIIKEVYVKQFDKFIDREDFMSTSSKTCDSLLDNNMLSRRGEDWRRIRNLCSPAFTTGKMKMFVKFFNETVDRTIEILKKYETEDKEIDMKELCDGMTIDSIFKSTFGYKTDLQEDPNNIIRVYCRRLFDASIYDPEFLFMLLFPEISKFLRVYFGYHVKINTEHNYFRNLLSECYERRKKELERGENNEAPDFFKVLLQSVNDEDIENNDREIVTESATENQKRKGMSKIEALSQGFLFLLAGHETTASSVHFLLFMLAHHQEYQDRCREEILEVLGEKSIDYIDYDTVNKLTYLDQCVKECLRMYPPSGRINRMCVQKTTINGIDFEPGCLVSIPIFTMHYNEDVYPQPNIFDPERFSPEQKAGRDPLYYIPFGYGPRNCIGMRYAYISMKVYLARLLLKYKFKTCPESLPIPLEITSRGMTKPIEKLYLKVETISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3B6</accession>
    <name>A0A0N5C3B6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3B6"/>
    <dbReference type="STRING" id="174720.A0A0N5C3B6"/>
    <dbReference type="WBParaSite" id="SPAL_0001247000.1">
        <property type="protein sequence ID" value="SPAL_0001247000.1"/>
        <property type="gene ID" value="SPAL_0001247000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000169">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001247000.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39126" checksum="185490E12B70CB13" modified="2015-12-09" version="1">MSKVDRGGAQQTSLLDVLKKKMRQAREEAETAKDEADEVKRQLEEERKKREDAEAEVAALNRRIVLVEEDLERTEDRLKTATQKLDEASKAADEAERRMTLLEEELERAEERLKIATEKMEEASANCDESERVRKVMENRSFQDEERANQIEGQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKSLELSEEKALEKEEAFDNQIRALDARLKEIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRNLTARLKEAETRAEFAERSVQKLQKEVDRLEDELLHEKERYKSISEELDQTFQELSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4M4</accession>
    <name>A0A0N5C4M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4M4"/>
    <dbReference type="STRING" id="174720.A0A0N5C4M4"/>
    <dbReference type="WBParaSite" id="SPAL_0001290400.1">
        <property type="protein sequence ID" value="SPAL_0001290400.1"/>
        <property type="gene ID" value="SPAL_0001290400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001290400.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29197" checksum="9BBB18E4786FB866" modified="2015-12-09" version="1">MVTEDRDYRRRSDSYSHRDYSRSRDDRHDRDGDRYRRYNGDRYDDSRSADRYRDSRNPDRERSSERRRSTRDYDYSSRDDRYDDRSSSRRRDDRRDDERYSRSSRYDECRSSDRYSDRRSPDRSDRYSSSRRSGGTRFSDDRTPRGAFRGRGAPRGRGGRGGGRGNAVTLHSVVLENLNENCSSVDLMRYGLENAGMPDVADVLGNGVGIIGYHDRSKFEEVKNILRKENKIPLLNGGFSTLTVGREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4S2</accession>
    <name>A0A0N5C4S2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase A(2)</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4S2"/>
    <dbReference type="WBParaSite" id="SPAL_0001295300.1">
        <property type="protein sequence ID" value="SPAL_0001295300.1"/>
        <property type="gene ID" value="SPAL_0001295300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001295300.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14289" checksum="68AD3857A637EE61" modified="2015-12-09" version="1">MISFKKLLLLNIYYYLFLQNITITLCAIIKPYDRNKWYCGTDNLMHGIAKTVTINACTLDEYVQINKCCYHHDNCYALKLGKERCDKRFCDCMKVKTKPCKLLTYGFCFATEGYGKDAYNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4X6</accession>
    <name>A0A0N5C4X6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4X6"/>
    <dbReference type="WBParaSite" id="SPAL_0001300500.1">
        <property type="protein sequence ID" value="SPAL_0001300500.1"/>
        <property type="gene ID" value="SPAL_0001300500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001300500.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29576" checksum="83EE3CAF307E14F0" modified="2015-12-09" version="1">MKVIFKMQEDVYQMKRAIIVVFSGSLNTNQLLRQAHSLVQKRILFHKLGSVNRYYASSFEALWFYVKQVFLDPKYRNFKAYITGHSLGGVFASLAAIKVQVLGLKKSQDIYLYTYGAPRFGSYIFSANFNIRIPNSYRIVLGSDIVPHFPPCKKVKDRDLKFYKKITRKLKRKTISRPCDPRDLHGYYHHGHEIWYPTGTECSFVECTGFPKNEDFECSDGLVYDSKTFHENARDHELYFKYLISLADKIFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Y1</accession>
    <name>A0A0N5C6Y1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0001369600.1">
        <property type="protein sequence ID" value="SPAL_0001369600.1"/>
        <property type="gene ID" value="SPAL_0001369600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001369600.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9832" checksum="A16555B7FEC14EE0" modified="2015-12-09" version="1">MIPFHQEAELEKLDKQLEEKVKEIQNKVYCATKTDKRAGCIEMEFEQKRYMILKDRTDECCKRLDKLKSDKFKDKFLLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7L3</accession>
    <name>A0A0N5C7L3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7L3"/>
    <dbReference type="STRING" id="174720.A0A0N5C7L3"/>
    <dbReference type="WBParaSite" id="SPAL_0001392500.1">
        <property type="protein sequence ID" value="SPAL_0001392500.1"/>
        <property type="gene ID" value="SPAL_0001392500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001392500.1"/>
        </source>
    </evidence>
    <sequence length="846" mass="97421" checksum="6C672D13E3ED3C04" modified="2015-12-09" version="1">MQSDHEKRKQISVHGIAQVENVSNIKNSFNRHLHFSVIKDRNVSTPRDYFNALALTVRDHLVSRWIRTQQYYYEKDPKRIYYLSLEFYMGRTLSNTMINLGMQAACDEALYQLGLDIEDLQEIEEDAGLGNGGLGRLAACFLDSMATLGIPAYGYGLRYEYGIFKQTIVDGWQVEEPDNWLRYDNPWEKSRPEYMLPVNFYGRVEKDQNGKANWVDTQIVFAMPYDTPIPGYHNNVVNTLRLWSAKAENHFHLKFFNDGDYLQAVLDRNISENITRVLYPNDNMFSGKELRLKQQYFLVAATLQDIIRRFKSSKYGCRDAVRADFSTFPDKVAIQLNDTHPSIGIPEFIRLLVDVEGLKMQQAWDVCVKTFAYTNHTLLPEALERWPVSLMSNLLPRHLEIIYEINQKFMDEVAQKYPGDFDRMRRMSIVEEADSMGEKRINMAHLCIVSSHAINGVAALHSDLLKSQTFKDFYEFYPDRFQNKTNGITPRRWLLMSNPSLSEVISEKIGDGWITNLDELQKLKEFSDDPTFLNDIMRVKQENKQKVAEWLKIEYGIKVNPESLFDVHVKRIHEYKRQLLNALHVITLYNRIKANPNGKYVPRTVMYGGKAAPGYHMAKQIIKLINSVAAIVNNDPIVGDKLKVIFLENYRVSMAEKIIPAADLSEQISTAGTEASGTGNMKFMVNGALTIGTLDGANVEMAEEMGKENMFIFGMTVEEVEELQRKGYNSMDFINKNSELKQIVDQIDGGFFTPDEPRLLQDLANSLKYHDRFLVCADYESYIKCQDKVNTTYDDKEKWSQMALFNIASSGKFSTDRTISEYAREIWNITPGEIDLPAPYERKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8B4</accession>
    <name>A0A0N5C8B4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 13">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8B4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8B4"/>
    <dbReference type="WBParaSite" id="SPAL_0001416500.1">
        <property type="protein sequence ID" value="SPAL_0001416500.1"/>
        <property type="gene ID" value="SPAL_0001416500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="14">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001416500.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20833" checksum="A311F0065566FD4A" modified="2015-12-09" version="1">MFKQIFESALFDEVRRMDGRQLIYQVLNFGMIVSTALMIWKGLMVITGSESPIVVVLSGSMEPAYFRGDLLTLYYDRKKPIEVGDVTVFKIEGRDIPIVHRVIKVHGNNVDDLKFLTKGDNNQVDDRGLYLPGQNWLKQADVVGQPHGYIPYIGMITIIMNDYPQLKYAVLGVLGLFVLIHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9M2</accession>
    <name>A0A0N5C9M2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9M2"/>
    <dbReference type="WBParaSite" id="SPAL_0001460200.1">
        <property type="protein sequence ID" value="SPAL_0001460200.1"/>
        <property type="gene ID" value="SPAL_0001460200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001460200.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27420" checksum="E14CA6D4233ECB6B" modified="2015-12-09" version="1">MERLDKKNRGSDKTKPLVHFMDPGDKEPSAMSVESFFQANYAVIRSVFPNVEERESYREELKDNFQNLLIRLLYNSLYGTLKMPSHHCQDRDYLYMIQLELSAVLDRAEKARKPIENGIQSHYALIGEMKETIQLGFERKIAEYIHKLHCKLGYDESHGINIVQDYFFHHYKIGEEQFKEMVWRNFNNFINQQKYRDLFTIAGTQMKFNEIPKKKRTGPRGNGKKRKKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Z3</accession>
    <name>A0A0N5C9Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_Tnp_Tc3_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0001471900.1">
        <property type="protein sequence ID" value="SPAL_0001471900.1"/>
        <property type="gene ID" value="SPAL_0001471900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001471900.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14249" checksum="5A55994A53BD0E0B" modified="2015-12-09" version="1">MSYQTILQYFNEGYKSAKEISKISRIPIRTVYYHLSKIKNPETKISNKTKSRSGKIPEKYIATIYQWIKKNENISAREIMRKLKSEKNLTVSRWTVQRFLIKHGYTNTISENELTLTENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA28</accession>
    <name>A0A0N5CA28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C76 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA28"/>
    <dbReference type="WBParaSite" id="SPAL_0001475400.1">
        <property type="protein sequence ID" value="SPAL_0001475400.1"/>
        <property type="gene ID" value="SPAL_0001475400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001475400.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32995" checksum="0713931A6362A47A" modified="2015-12-09" version="1">MCQAALGRNNQCTAMSFASLIMACIKSPLNWDKVDINNVLNQGNILYERSVNYLRSTNYSIDGRGYLSVTNIIRETILFNRKVTFSTASCYSFTGRGKKVKRNEISFGFVSLSQALNRLVNEHQFLILIANERASSIIHHDGAFFLFDPHSMDQNGRYCSNGVSCMLMFNTLGDLIEHLQANQVCNNSIFDLNGINISVENISDVNSDISTTKKKKLSEKKKIQKQLNRLEKKSNDTVKKNCIDILKINEVFDNNLKKGFDLEKDEPMEIDICQKNTSQILMDFDVDIDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAB4</accession>
    <name>A0A0N5CAB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CAB4"/>
    <dbReference type="WBParaSite" id="SPAL_0001483700.1">
        <property type="protein sequence ID" value="SPAL_0001483700.1"/>
        <property type="gene ID" value="SPAL_0001483700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="610"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001483700.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="89436" checksum="0BFAFE3BD3B1C8AE" modified="2015-12-09" version="1">XEIKRKLLMASYSKTPKVGEGDVVGKDDSQNDLKSPLKKRGLCIVVSDSDENIESGDSDAEKLSISLSKSSLGTTQKYEIKNLYGLRNQISSIEMPKISETDLLRIAKNKKVKRTHNIPDESQNRQEDPEYDPKTLFILDWYMGKQSKYQKQWWKIKQLHMDTLICVKNGKFYRFYHMDAEIAHKELGLELHKTNKNGLCQVSFPIEAYGKRINELISLGHRVTTAEKVKQSEDDDDDFTTRVYDPAEEFDGVKVYEQTEDKNLAAVWVELNESGTYDYGITFVNTAIGNFYLTQFTDDCINSSLTTILSRFQPAEVLIEKGCPKNVVGLLRSYLPCSKVESLYQNSKFYDPEKNLFVDIVKILEGSRILDQDGALNDMFGGDNFYFTAEDIKSFDKYFDQYAALKGGTSFSSLEINEECNEIVEKADMYRKELDEYLFMLKRTMKSDKIEYLKDELNYYHVKVPRFLRGKVLSSLRKSSYKITDYLIYISTDIQDTVQKLVTVEDELIAIKHSFLKTVFETFNKKSEQWKRGIEKITYFDCVLSLATFSSTFRLKMSFPEFDFKSPTPYIDISEGHHPTLATNMHHTINFGNQNHTYMPNDTVFGKSKGVAMLLTGPNMAGKSTLMRQVATLVVLAQLGSKVPAKSMKLTPVDRIFTRMGASDRIFCNQSTFAFEMNETNRILRGATKHLLVVIDELGRGTGTIDGISIASATLEYCASKIGCITIFTTHFQKMCDIFKDHKDVFLAQIDCHVDSKSDDPTYDDVTFLYKIKDGACKQSYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAE3</accession>
    <name>A0A0N5CAE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAE3"/>
    <dbReference type="WBParaSite" id="SPAL_0001486500.1">
        <property type="protein sequence ID" value="SPAL_0001486500.1"/>
        <property type="gene ID" value="SPAL_0001486500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001486500.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10612" checksum="D2BD10EA6811CAB7" modified="2015-12-09" version="1">MELGIPTPASKQIWKVNEELFVVATITDGVSILKSFKPTSLKCSSAATIKFLALPKKTSTTIKNRSRLILDAIDLGTTSLKNIEKLSREKQLRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAY9</accession>
    <name>A0A0N5CAY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAY9"/>
    <dbReference type="WBParaSite" id="SPAL_0001505500.1">
        <property type="protein sequence ID" value="SPAL_0001505500.1"/>
        <property type="gene ID" value="SPAL_0001505500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895629" evidence="2">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="93"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001505500.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25956" checksum="FA1B8EFE2DF63C47" modified="2015-12-09" version="1">MLTFPLFLAILFIGCQTYENKETGGESASFNLRLNDVSYYSNNIGEGGSKFNLMSGYVENKDQQKRQARKRSAKSKASKKVSAKKPKKPLYKDINKLREKYFKPPLQINKTLSLELQDYVKKFIKNDSGLKPMVPQPTDLYYYCFSNEKYDPIGYWSKDAGFFLTYDYIYKDLIDLFYTKLLWKSSTHIGCGVYGDEYGVATYCRITPRGNIKGEYKKNIFNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB97</accession>
    <name>A0A0N5CB97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB97"/>
    <dbReference type="STRING" id="174720.A0A0N5CB97"/>
    <dbReference type="WBParaSite" id="SPAL_0001516000.1">
        <property type="protein sequence ID" value="SPAL_0001516000.1"/>
        <property type="gene ID" value="SPAL_0001516000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895894" evidence="2">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="3">
        <location>
            <begin position="364"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001516000.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="44743" checksum="0AC743C8D3D1FFEB" modified="2015-12-09" version="1">MVKFFLSTAILALVAQSGNACFGGLGGGNACCPPASNTCAPSVPKCQTTSYAAPPVPAPSGYAQPPPSYIAPPPPAPSGYAQPGYQGYPRPFGVQGPVQPSYPSGGINAGYASSIDSGAASAYVQQKVPSGGNYIQGPGPVGPAPVEPTPQVPQPGGGQVVQPGYGGEVTQPGGGEVVQPGGEVVQPSGEVVQPSGGVQEPGYEATHAPGYGGEVSSQAPTVVVASTEYTKEEVVTPSEVPSSYSGSQTTQGAGYGGGVQVTSSPSYSGSQTTVGGGYSGETETKSVVTEEGYEKEAVKPIVNQSKYEEQLPSTAAPAPSKEGYGGEETIKEKSGYDQGHENSVAPSQIGAVDYGEETNTSGDGNCEDPELRAIVEAAVNSHSDNLEAARKIEADAGSKFGGRFNSIVSNSEFAYVNWYGKRNCQLRVKERHTLTWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBC1</accession>
    <name>A0A0N5CBC1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="3">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBC1"/>
    <dbReference type="STRING" id="174720.A0A0N5CBC1"/>
    <dbReference type="WBParaSite" id="SPAL_0001518400.1">
        <property type="protein sequence ID" value="SPAL_0001518400.1"/>
        <property type="gene ID" value="SPAL_0001518400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST N-terminal" evidence="19">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001518400.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39696" checksum="B1FD344A4CE0F91F" modified="2015-12-09" version="1">MWRRGFCAGRRIYSTGIYLGGTSLAATVLVQEKDDRVDGVDVLSKARHITGPLDKTGLKPRLYQYQACPFCCKVRAFLDYYGFDYHLIEVNPLSRRELKFAPGQKKVPVATCSCLDKPLTESSLIISIFSTFLQRKELSIKDVVGLYPPLTQVEARSGKEVQTFPNKYFIMLEKDYKWNSEIQAAREEREWREWVDNHFIHIISPAIYRTMQESIETFIWFSKAGHWEDIFNFVERQSAIVVGAVAMYFVSKSLKKKHNIDDARKAMEESLNKWMAALGTSRTFMGGREPNLADIALYGAIQSFVGLDCFEEMKKKTDIEKWYNPMDKLVKERYGSKYLKNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBI8</accession>
    <name>A0A0N5CBI8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBI8"/>
    <dbReference type="STRING" id="174720.A0A0N5CBI8"/>
    <dbReference type="WBParaSite" id="SPAL_0001525400.1">
        <property type="protein sequence ID" value="SPAL_0001525400.1"/>
        <property type="gene ID" value="SPAL_0001525400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000664">
        <property type="entry name" value="MonoCarboxylate Transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="22"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001525400.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="62773" checksum="07AC6DFA630B199A" modified="2015-12-09" version="1">MTAITGRKPSRYVPIATDGGWGYVVVFGSFLIHVIADGIVYAFGVMATALMHHFEETNARVSIIVSLLVGLTLASGPIASAITNKIGCRLTTIAGAIVAAIGLMAASFSTSLEMIMVTAGAICGVGFGLIYCPAIVIVTMYFEKYRALATGIAVCGAGVGTAVISPLQEYLIQHYSWQFCMRVNSVLALLCVIAGLTFAPLEFKEVYDDEEDDDTPTENQVENINEEVTDKQIMKDNSEKKSLLDAKNMRPAISHQDISDASKTSNLKKAISHADSLHKSRSNTVTDATGYLNVKDSFYQGSVTNLPEYQENRDKFRSISSLHSRKSSHIQNDGKKIINEEDEKQLVSQSTDDDNDGNTLMDTLKSLTDFGLLKDPIFMIFAISNFLTSVGFNAPMAFLPSHGEKLGLAKEEASLIMSAWGVCNTVGRILFGIVSDRKLPFRFGKDLPRNRLWIYNISLIINGIVTACCFFFTSFYGIVAFGGFIGLTISSYVCLTSVILVDLLGVDKLTNAFGLLLLFQGIATFAGPPIAGMLADMTQSYIISFIMCGVCVAVSGAMLFGVPSLQRKLNRVPKDSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC30</accession>
    <name>A0A0N5CC30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spindle and centriole-associated protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC30"/>
    <dbReference type="WBParaSite" id="SPAL_0001543900.1">
        <property type="protein sequence ID" value="SPAL_0001543900.1"/>
        <property type="gene ID" value="SPAL_0001543900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001543900.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24287" checksum="B28C2468704008F5" modified="2015-12-09" version="1">MSAVSGVETVRETLRIVKDNYRLLLHISEKQEHLADRIDELEGRIRVMRVKNRYDSPPPSDTETSTLKIGDNNNEVFTTNGLSFTDSSDSEDDFKDASQALPSTVLDFKQKIGADYPCTLYYFNEDGRIEKRGPVTCAFMKVKSGYILEVTNKETGDDLQIICGVGGQSMYEVKKKDGYIVIRIKTGALVYSMAGIASILLKFVDGVAGSKVYKGLSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCP9</accession>
    <name>A0A0N5CCP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCP9"/>
    <dbReference type="STRING" id="174720.A0A0N5CCP9"/>
    <dbReference type="WBParaSite" id="SPAL_0001564900.1">
        <property type="protein sequence ID" value="SPAL_0001564900.1"/>
        <property type="gene ID" value="SPAL_0001564900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF95">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR C06G4.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="37"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001564900.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52752" checksum="606A1AE5810C6C9A" modified="2015-12-09" version="1">MQKEEIFEVLPPPNHEDSHVLTMAICYMLLFLIGICGNVAVMTTIYHVVRSQKTTIDNTLIYVIVLSCVDFGVCMSLPFTVIDQILGFWMFGSVLCKLHAVLENFGKILSSLILTAMSFDRYAGVCHPHRKYLRSKKLAITILVGLAIYALVTLCPLLLNFSARELILFEKETAPYKITRMRIEKCTMSNMSSFSFSTFTIYQCVLCYIIPLILVVYFYTRLLTRLRHHARQFKSSQIPLLRISVYTMMVSLFYFLCWTPFWIATTLAVYLEYVEEGQGSSAVPHFFVYAMYFIHALPFTNSAVNWILYGALNSQLQLKQRSSSNFRSEFTNNCLQSYNNAVNQTGGNKNNPTLSNNDNSFNNNSKTFDSISKKDSDKQHLQITYKFSAPLSLGTDSSYNSKGSATEMTTLLPNGLHKQSSPNNPFKKISSETSIEQIKEDEDDKNKDNLIVIGYDCDSEGTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDP0</accession>
    <name>A0A0N5CDP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDP0"/>
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        <property type="protein sequence ID" value="SPAL_0001598375.1"/>
        <property type="gene ID" value="SPAL_0001598375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001598375.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16596" checksum="7B69530EB8F2A208" modified="2015-12-09" version="1">FDGVIFIVVFDVVFGVVFSVFGLVVFGSSGTCGDFFVVIRFESEGFLVTFLVFAFFRVVLFRAGDFGVDFLFKVFFGVIFFPEETTFLLDVILDLACLLTRTSLNYFRSVSLRATIFDCISFHLNLLVMIFLNHFLLMNLNFNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDX0</accession>
    <name>A0A0N5CDX0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDX0"/>
    <dbReference type="STRING" id="174720.A0A0N5CDX0"/>
    <dbReference type="WBParaSite" id="SPAL_0001606100.1">
        <property type="protein sequence ID" value="SPAL_0001606100.1"/>
        <property type="gene ID" value="SPAL_0001606100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001606100.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="40481" checksum="5DC9A20C9EC76592" modified="2015-12-09" version="1">MKAFIRNSLIFFLVLAIFSILYQTTITVFDNIYYDTYNSIDNANTTADTSINHILHPHQIAIVMVIESASESNYEQAMETVKCYSLHYNYTFVILHQEKVPEFSYNCHYEDFMFRRHCIVANYAQKYKNEIKYIVFIDGDIGVVNPVHRLENYLPKDGEDILFYDRTFNYEIMAGSYIIRNTLYTRSFLKYFADYEYKMPKTNNGRDNVALQPVFVDFMGTVKYRNKYLQCMKIYNYAVGFDENMLFVSCMRYVLNLMDETPNDINYHTYEGGKIKIVRKLSKKRWARDGWLSDWKFCNDDLFHHAWKQEEIRKQKIVFKGRFLANKKKCKGSDFLKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE07</accession>
    <name>A0A0N5CE07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPASM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE07"/>
    <dbReference type="WBParaSite" id="SPAL_0001609700.1">
        <property type="protein sequence ID" value="SPAL_0001609700.1"/>
        <property type="gene ID" value="SPAL_0001609700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001609700.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37429" checksum="C86BA8B89976B56A" modified="2015-12-09" version="1">MLLEKKVLSSANGPSKVDWKIIHNIRLVSKFFNDFVSSNIDNLPKPMMTSLSISSTYNPDEKMHIEFLYLHENEYIKVEDVYIPSENNEQRLPEMENLLLKMNLKNVMHFEIVVTGETIIFDVLDRYLKFGTTVESLQINIQKCPSFEGFSRFIRKISQPIPVDFTLPMIDNSNNLCLVECECTKFVNPKMITNLYCNNKNLKRILVFSNCTNMEYELIKVIKEKQELCSGKNGCHSNCYLYLPLRNNSIHDVEIINNFPLNAYDISSPLEMDNTIISVEKCSKCAASYGIALSYRKSTYLNDTNCDYAFGRTFFIDDNFYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEC0</accession>
    <name>A0A0N5CEC0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEC0"/>
    <dbReference type="STRING" id="174720.A0A0N5CEC0"/>
    <dbReference type="WBParaSite" id="SPAL_0001621000.1">
        <property type="protein sequence ID" value="SPAL_0001621000.1"/>
        <property type="gene ID" value="SPAL_0001621000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="12">
        <location>
            <begin position="86"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001621000.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65560" checksum="3ADFAC0BFEE047E7" modified="2015-12-09" version="1">MAAYYSGNKAGFDGLDKDKIAKIIAENSGSKYTDFKTKQDEKLNKRVNSLKERISKLSDKEIREAEKKVDKYIMYHEQNRNLNYVMLHIDMDAFYAAVEMRDDPHLRDVPMAVGELSMLSTSNYHARKYGVRSGMPGFIGLKLCPHLKIVNCNFDKYRKVSHKVQEVFNSYDPNFSMGSLDEAYMDITDFMLTRKEANILERRRYKGDCVCKLPIVHSDDEEGICKVEEIKETCLKCRKKRVCVVDKVSFGITEAEVVKEIRFRVQQATGLTCSAGIAANWLLAKICSDINKPNGQFELKRDREEIMNFMSKLHVRKVNGIGQQTHGLLKAINIDICEDIYKNRGILKLVFSEINWTFLIRTYLGIGHTITESSKEDSKRKSISVERTFKETGDVGKCLSYLKGACEELIRSLEHQNVRGGRVVVLKCRKDTFERYTRSHTVAELVSNVDQLFAIGKDLILKEMNEAPVKYRLIGIGLSRLSFFDKDDDIDEELSSTDGESRGPQNYFSEKYDSADNDIVCLSEENIEIIEITDRKERNKNIASIDNQKKQSRKRPGTNLDLFLISSKKGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEP8</accession>
    <name>A0A0N5CEP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEP8"/>
    <dbReference type="STRING" id="174720.A0A0N5CEP8"/>
    <dbReference type="WBParaSite" id="SPAL_0001633500.1">
        <property type="protein sequence ID" value="SPAL_0001633500.1"/>
        <property type="gene ID" value="SPAL_0001633500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001633500.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19141" checksum="0A6A61B831698709" modified="2015-12-09" version="1">MQRYPLSIVMILTWSRNGNFVSDFWQWTDLPSFFVALALFTAAASLITAVFIQFSWFVNALGLCSLLIEACLGLPQLIRNFKRKSTIGMSVTMVLGWFLGDVGKTIYFIIKKTPFQFYVCSCLQITIDILILIEVIVYKKSASQTSHASSISSKSSSIVDLPETNDLRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEZ3</accession>
    <name>A0A0N5CEZ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DBF4-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001643100.1">
        <property type="protein sequence ID" value="SPAL_0001643100.1"/>
        <property type="gene ID" value="SPAL_0001643100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001643100.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43290" checksum="E8A8BC35E1B980C7" modified="2015-12-09" version="1">MAKSKTCLNNTPARHNLPKSYSEITPNCVKSNIQKLDNRIRDKENIKTTLISRPSSVVSLSSPKAYNIHPPFKKDFSLLKGKYVFVEIRSSSTRGKIMRSIEICGGIPLTSPDSKIPFVFAVSDNPALYKVKREDYKKSMEHVLKFCDRLNLCVYSASYLYSYFKELAQSKKSKDSDNKLPLPKTNVPINLRGYYIKVQHYKNPSAPFVKFSEKSENFLKMYMGDSAGRSAFHAISTEENKKKQDRKKGISHAREKKLKLDGYCEFCNIRVPDRFNHCQMDIHRRAINDRSSDFKDLDKYLGFFDEDFMLTFKHPNVKRNIIKVHHSINKGKHSKEHDVDDSLSQKYLETRYKVEKLPDVGNKGMVQDILNSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHX9</accession>
    <name>A0A0N5CHX9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHX9"/>
    <dbReference type="STRING" id="174720.A0A0N5CHX9"/>
    <dbReference type="WBParaSite" id="SPAL_0001744100.1">
        <property type="protein sequence ID" value="SPAL_0001744100.1"/>
        <property type="gene ID" value="SPAL_0001744100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001744100.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18868" checksum="BCE8CE10E65CA083" modified="2015-12-09" version="1">MNVSNIRLLFNSILKQNSITKIYIDGSFRQDLKCKSNAGIGVYWGDNDSRNISLKLVGNHTSSTTELNAALYALRQVKKLKIENAHIYSDSIYVVNSVNDWVHKWKENGWLTYGKKDVKHKELMIELNNLIEITGAKFYHVKGHSKHYGNEQAHDLAFKASQNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHZ6</accession>
    <name>A0A0N5CHZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001745800.1">
        <property type="protein sequence ID" value="SPAL_0001745800.1"/>
        <property type="gene ID" value="SPAL_0001745800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001745800.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19141" checksum="47BD82BCAD15B019" modified="2015-12-09" version="1">MCPIYKAKTTIILLIIILSFIISSEIIELKGYIKCETKDVSKNTNVELYKVSHFSEDELIKQTSLSTSSSFSITAQLYDEVHYYFEIKSKCGIKLFNSTCHKITRYPFDLVLEKELDTKKMIIDFSTIFLDIYYDGSVIKCTNKTHFPPIEDKGIIKTIENLFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIB7</accession>
    <name>A0A0N5CIB7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CIB7"/>
    <dbReference type="WBParaSite" id="SPAL_0001757100.1">
        <property type="protein sequence ID" value="SPAL_0001757100.1"/>
        <property type="gene ID" value="SPAL_0001757100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone H2A C-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001757100.1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6354" checksum="6A4F68FF6440CE9E" modified="2015-12-09" version="1">XARDNKKTRINPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIPSSLIPKKAAADEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIR1</accession>
    <name>A0A0N5CIR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001771600.1">
        <property type="protein sequence ID" value="SPAL_0001771600.1"/>
        <property type="gene ID" value="SPAL_0001771600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001771600.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12655" checksum="BF5B71A6BC3CDDFD" modified="2015-12-09" version="1">MAAQINRCIAQSKESKNYLWYAKHVILPNIVKSMAMGKKYYDVIKNRSSVSIKVLNFTRIILTLHLSFTPSFSKKQENWRNEIRMTSAKKRNKSDAIECIEILSDSNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CJ08</accession>
    <name>A0A0N5CJ08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CJ08"/>
    <dbReference type="STRING" id="174720.A0A0N5CJ08"/>
    <dbReference type="WBParaSite" id="SPAL_0001781800.1">
        <property type="protein sequence ID" value="SPAL_0001781800.1"/>
        <property type="gene ID" value="SPAL_0001781800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001781800.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31016" checksum="C604E7D967DE5C54" modified="2015-12-09" version="1">MEELCHNKIDITIITETKVKEGISKKCENSIISCGKSSKKCVGGVGFAISNENIIKHIKVIEHINFRLSYMIINIDKRKSLGIIAVYAPTNCYDDIDKDEFYLQLHSLYAKVRQMSTVTILAGDFNGTIDSQIIPKIKGRYSYDELNDNGERLINFCTQNRISIVNSFFKKRWWKKFSWIKPQSIEDNIKGRLCVKQLDYFLCNMKRIFTDVETWSHKKFDATVSDHRLVKATIKFPKKLCDYIKKSRCLQKKVLHYNINYEKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B265</accession>
    <name>A0A0N5B265_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B265"/>
    <dbReference type="STRING" id="174720.A0A0N5B265"/>
    <dbReference type="WBParaSite" id="SPAL_0000016800.1">
        <property type="protein sequence ID" value="SPAL_0000016800.1"/>
        <property type="gene ID" value="SPAL_0000016800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF368">
        <property type="entry name" value="CUTICLE COLLAGEN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000016800.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="32660" checksum="B734D9D9ADC7E3BA" modified="2015-12-09" version="1">MDSKDTSKHKQMRSIAFVAIVVSTAAVFASVVTLPMLYNYVQSLQTHLLSETEFCRVRSKDMLLEVTALQIGKRQNHRIKRGWLFGQYIADREGQFGGGRRTSGGSSGGNMGGGYGTAAVNSEPEQVCCTCHQGPPGPPGRPGPEGVHGKDGDHGKDGHPGKDAELIPAEPYEPCIICPPGSIGPQGPMGPKGAPGPKGSQGENAKPGMNGEKGPPGAEGTPGRPGRQGPKGSPGQAGRLIYVQGPQGIQGPPGVVGQPGLKGPKGAPGNSYPGPPGPQGDQGAPGKDGRAGAGGIKGKLGDQGEVGSCDHCPAPRLPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2E3</accession>
    <name>A0A0N5B2E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2E3"/>
    <dbReference type="STRING" id="174720.A0A0N5B2E3"/>
    <dbReference type="WBParaSite" id="SPAL_0000025000.1">
        <property type="protein sequence ID" value="SPAL_0000025000.1"/>
        <property type="gene ID" value="SPAL_0000025000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000748">
        <property type="entry name" value="RNA Binding Motif protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000025000.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10562" checksum="06AC61248B3002B5" modified="2015-12-09" version="1">MEGPVATEMASQPQKFSVYVGNIPYSANENEIGRFFSTVGHVVNVRFVYDRETRRPKGFGFCDFSDLTGAQAAVQNLNGSDFNGRTLRVNYANKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W7</accession>
    <name>A0A0N5B2W7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2W7"/>
    <dbReference type="WBParaSite" id="SPAL_0000041900.1">
        <property type="protein sequence ID" value="SPAL_0000041900.1"/>
        <property type="gene ID" value="SPAL_0000041900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000041900.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10575" checksum="C59A5D9075F4388D" modified="2015-12-09" version="1">MEHIFISQLIFVQFLFNFYTSTNISIRSVLLIDLLKEVDFQICYIASFVSPTHLLHYKKSTMDYYFKYNELNHANFDTSFVFFIILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2X9</accession>
    <name>A0A0N5B2X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2X9"/>
    <dbReference type="STRING" id="174720.A0A0N5B2X9"/>
    <dbReference type="WBParaSite" id="SPAL_0000043000.1">
        <property type="protein sequence ID" value="SPAL_0000043000.1"/>
        <property type="gene ID" value="SPAL_0000043000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893671" evidence="1">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000043000.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33415" checksum="7FC4CE78C215C08E" modified="2015-12-09" version="1">MYTIFIFIFLIKFLYANDLNPVVHLFIKDQPGDMDYAIDEVSCTGTILGGKFIITAAYCVFTMDHCEKNIMKDYKNLYIPGKRITVEYDSFCAHSRKECRENQRPKTVRVERVFIHKKYIKSNCKEGGLAILELSENIGDRKMAINFKNNFLPQKLLGFGFGYNPYKSDRTFTLQYDTFNVTKCLAPEIPEGTFCTDETRNNFCKGDGGGPLMTRDRILYGIVYAGTTCDYIIKVWKKKSEKESLRGHRNYLTSHFLNFICTIVQEDKENPVEGCEKYENVSNTEITTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B392</accession>
    <name>A0A0N5B392_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">(3R)-3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="19">1.1.1.239</ecNumber>
            <ecNumber evidence="4">1.1.1.n12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">17-beta-hydroxysteroid dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Estradiol 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Testosterone 17-beta-dehydrogenase 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:24614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:32712"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14929"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.239"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14930"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.239" evidence="19"/>
    <dbReference type="EC" id="1.1.1.n12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B392"/>
    <dbReference type="STRING" id="174720.A0A0N5B392"/>
    <dbReference type="WBParaSite" id="SPAL_0000054400.1">
        <property type="protein sequence ID" value="SPAL_0000054400.1"/>
        <property type="gene ID" value="SPAL_0000054400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047035">
        <property type="term" value="F:testosterone dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000231">
        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="26">
        <location>
            <begin position="10"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000054400.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="26266" checksum="A38291D6CDCE022B" modified="2015-12-09" version="1">MSISTLLIGKTAVVTGGANGIGKAICSKLVEHGVKVCVVDLKKENAIETAKLLGKENYGFGCDVSKLNEVESLKEFVSKNMNVTPQIIVNCAGITQDSTILKMSEEQFDNVIAVNLKGVHLITQAFARLAVANNTPASIINVSSIVGKVGNFGQTNYAATKAGVIGHTKSAAKELAKKNIRVNAIMPGFIETDMTSAMPPKVLEQICKGIPMGKMGKPEDIADAVVYLGSDMSKYVTGSIIEVTGGIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3B6</accession>
    <name>A0A0N5B3B6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hyaluronidase</fullName>
            <ecNumber evidence="6">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3B6"/>
    <dbReference type="STRING" id="174720.A0A0N5B3B6"/>
    <dbReference type="WBParaSite" id="SPAL_0000056800.1">
        <property type="protein sequence ID" value="SPAL_0000056800.1"/>
        <property type="gene ID" value="SPAL_0000056800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="38"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000056800.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="42326" checksum="C7B2366C2A479F1D" modified="2015-12-09" version="1">MPSQRTFNNLKYFFLLIYVLKFYVFPTKILWNIPSEQCERTNSTKIDFSKYKIETNYHCKFRGEKIIVLYENDVGLYPHLKNFSNGTIQYINGGLPQLVNISEHLKKLGQSIKNIITDKHFNGLAIIDIEEWRPTYDSNWSSKRVYQEESVRLVLKDKKFLNKTEAINLAKLQFDKAAFRFFYATLKMCKLLRPRAFWGFYGFPTCNENAQNRNWSFCFPEISNKMISFLKYADVIYPSPYIVPGQNYTVKSFFVREVLKETNRIVEEIMRLGYGKKLIYVYNKIEVDPFVAKPKNIEFFDPYYLCIVYDNCVLHNVDGVIVWSTSKNMKERCHYIKDYVDHIFGPHIKFLQLYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4G7</accession>
    <name>A0A0N5B4G7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B4G7"/>
    <dbReference type="WBParaSite" id="SPAL_0000096900.1">
        <property type="protein sequence ID" value="SPAL_0000096900.1"/>
        <property type="gene ID" value="SPAL_0000096900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000096900.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60510" checksum="D629C96598EBB240" modified="2015-12-09" version="1">XYFINVQVTSTSFDDIVIRVCDYLRTRPVKRKEVSKNVGSTFNLDKKKDRDSEKERKPIVCHFCREEGHIKPQCPKLKSSQDKDDKAVGKSNMKSSRVLEDMQSEYKRLLESFEQLQKENHVLRGKCDDYVSSKVLMEEADAQPVVNVRNADRIVRDICVKTKLSTKVNAIVADAMLDCGSHISIVSESIARVLGYRNNNVSDHKFYVANRSVMENLGEFKIKVSFEGDCDIFVKFVVLKDSQIESPLGRYRLLLGNDVLYGLKISIDFERFEISVMGRKIQSIWYKSDANFKTMFKAKPVMISRVAMCSKSELSDLEQDYGDIISKSSNDIGKLRISVPKLPLRNEPIPKVKRYVHSFKVAKEISKCIDEWCDMNVLVPGEPKLIMNLTTVPKKDYQNFVMGKDENNEDILEVREIVSTRVCLDARPINSMLENWNYPTKSLNERLVNLHGAVLFSKIDLRQFYLQISLHIDDVTLMGVQHPKTLQLFTFHRLPFGLKVSGNYAQYIIDQTLKEVNFNSDEEGAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5E0</accession>
    <name>A0A0N5B5E0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5E0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5E0"/>
    <dbReference type="WBParaSite" id="SPAL_0000128300.1">
        <property type="protein sequence ID" value="SPAL_0000128300.1"/>
        <property type="gene ID" value="SPAL_0000128300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000128300.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15438" checksum="9190F573278B1848" modified="2015-12-09" version="1">PKRYFIKDVLPERSAKEGRCRCVIISFFRGSYLIGSPSLPEYNGSALADKTGSIAVNINYRTRVFGFGRLRREKMAPGNMVLLDQQIALKWIHENIGKFGGKNDMITLLGHTQKIKRTNFDNSIYNAKKCPTILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5F4</accession>
    <name>A0A0N5B5F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5F4"/>
    <dbReference type="WBParaSite" id="SPAL_0000129600.1">
        <property type="protein sequence ID" value="SPAL_0000129600.1"/>
        <property type="gene ID" value="SPAL_0000129600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000129600.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39883" checksum="8DBF01FCE97D2B66" modified="2015-12-09" version="1">MAPPEKYSISDYGCKRTYSRFLQLVTSHLAEDDRVATILNSIPINWKNRFLKSIIQAGEESCLTSEGLLKLIEEEGTKEADSEPVAVAINKVFSIKFNFKEKNACRNLLNDIETALNGLISDQSKSELIPMFFVQLIPNKLKKEFKDSKLPTVEEIKKFSREQDLIFHNSSVFGFDSDKKRSLERKNSKNLDDKKDEKNHHKFNEIKNPRKQSDCSELRPIKKEKSYEIKFQNLSSNFDYSSIATTEALISDNSTCIKVGLDSCASLNSITLSDFEKLPEMIKNNLVIDKETYILKGIHNSESETLGYVETTISLPNFKVENEKIKFFVDPNAELSLLSYSFCKALGLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5H9</accession>
    <name>A0A0N5B5H9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5H9"/>
    <dbReference type="WBParaSite" id="SPAL_0000132100.1">
        <property type="protein sequence ID" value="SPAL_0000132100.1"/>
        <property type="gene ID" value="SPAL_0000132100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000132100.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8981" checksum="15C6B41EBBCE8FE3" modified="2015-12-09" version="1">MRHGFIPKDGDLVLQKIIHRKDAITSGKNQPIWEGPFKVNKNLYGNTYEIQRIGDHHRTRSAVYKVHADRLKCISNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5S2</accession>
    <name>A0A0N5B5S2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5S2"/>
    <dbReference type="STRING" id="174720.A0A0N5B5S2"/>
    <dbReference type="WBParaSite" id="SPAL_0000141700.1">
        <property type="protein sequence ID" value="SPAL_0000141700.1"/>
        <property type="gene ID" value="SPAL_0000141700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893779" evidence="2">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000141700.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="14614" checksum="F19E714092352F3D" modified="2015-12-09" version="1">MKFITIFAVLFLTIPMEVNGASCDQMAATGYCLNSMYRKIMCENCATKCDALGGSAACTLPTKTSACSDQATNCASLAYLCTNELYKNLLAQKCMSTCNTCDGKPATTTTTAAATTTVAATTVVTTTNATATNGTATNSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B625</accession>
    <name>A0A0N5B625_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NARG2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B625"/>
    <dbReference type="STRING" id="174720.A0A0N5B625"/>
    <dbReference type="WBParaSite" id="SPAL_0000151500.1">
        <property type="protein sequence ID" value="SPAL_0000151500.1"/>
        <property type="gene ID" value="SPAL_0000151500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019535">
        <property type="entry name" value="ICE2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10505">
        <property type="entry name" value="NARG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Little elongation complex subunit 2 C-terminal" evidence="2">
        <location>
            <begin position="594"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000151500.1"/>
        </source>
    </evidence>
    <sequence length="823" mass="94148" checksum="D788C11BBC853E34" modified="2015-12-09" version="1">MDSDSELQICEQPETSDLVDNRYSSDNLQKDYEEQTENSCDNIQTDINKGDEIPKVCPSFSKVNKTEDQPDCNNDLIAKSNVTSKFQNDNINITKKKPQGTNRKFLTPLMKNALKQSRQEVSLLDHTKKTDKKDQNITIAKNIDVVEKVQTKPNRVRSAICIDASDAPPMKMAKKPKPSNSLLNKITNIKQNSSSKSLLKTPVPATSGSSVESTKLNRLPSNLVISNLKKQYNCSKEEAVRKFVEKCRENNSKVDNASNAEENKLRVQADEMPWIPNFIFPDRNQFTSLSDADHKRYVAIIMNLINQNPEFRFVHNVTELKDFDNRLLSERKLFHKISFEAIDSKKKSCYRFKLPSWNKMIYSFTEARSKDLKKFSKDEYEVIDNYEFNSNIEALSLSTLRIHEESQGDGAVVNIPDLRKKCIFNSKTIHEKKKFYSVNSINADKNAEVISSTHDARILMDATTFSRLLIGKWGCDNLEYSFPINVAQEFVDGGLENIVTISKPIPSSPPSTRTLAYRFMKYVVKGAVDKNYFDIPKEAVNDTQNESEIDDFAPSSPFFPTSPTRANDDSTPNIIEHTNENKANDDNSYHRGKIYHILNLNTGTSDPNFNILVRSNCAEKDCFGKKLSVSHHVEYFPEIGAENLFPEEIVRNYIKCFFKDANHAVIFRVHSSSYNVLQKEFIDLHTLQNRVYNECLNIWKNGLQKVRNLLMKLMTVSGGEYLLEEDDNNFKLYSKTIPIEDDTENVQTELRKALQGSNQEDDMIRNGALNSSGIFNGVSYHVPLMWNFVLSRIPGSLPKRKKNVNQDTFHNNKGKHKKKFINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6F6</accession>
    <name>A0A0N5B6F6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6F6"/>
    <dbReference type="STRING" id="174720.A0A0N5B6F6"/>
    <dbReference type="WBParaSite" id="SPAL_0000164600.1">
        <property type="protein sequence ID" value="SPAL_0000164600.1"/>
        <property type="gene ID" value="SPAL_0000164600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000164600.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17986" checksum="33FB7359FDD2E27D" modified="2015-12-09" version="1">METQKKIDIDNLSIAQLGQFSKAAEEEINFLQESLEQLKLIRQKFINSRDTVKSVDPKEANKKYLIPLTETMFVRAKVPNPDEYLIEIGTGYYVQMNRQKAMEYFERKEKYLNERVQEVEKIINEKKATRQALVSSLQEKVAKQASTTNPQPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6H4</accession>
    <name>A0A0N5B6H4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6H4"/>
    <dbReference type="STRING" id="174720.A0A0N5B6H4"/>
    <dbReference type="WBParaSite" id="SPAL_0000166300.1">
        <property type="protein sequence ID" value="SPAL_0000166300.1"/>
        <property type="gene ID" value="SPAL_0000166300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000166300.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41079" checksum="9D930973557B5E0A" modified="2015-12-09" version="1">MTFEGKVISCKAAVAWAPNTPLSIETIEVAPPKEHEVRVKILYTALCHTDAYTLSGQDPEGLFPSILGHEAAGVVYDVGPNVTEFKAGDHVIPLYVPQCKECEYCKNPKTNLCQKIRVTQGNGVMPDGTSRFTCKGKSLYHFMGCSTFSEYTVVSDISLCKIDKNADLKKVCLLGCGISTGLGAVKNTCKVEKDSTVAVWGLGAVGLAAVMGAKMVGAKKIVGIDTNPRKEEVAKMFGATDFENPKNAPTDKSFQSYLVEKYDGGFDYTFECIGNVETMRQALEACHKGWGESCIIGVAGAGKEISTRPFQLVTGRVWRGTAFGGYKSKDSVPKLVDEYVSGNLKLDEFVTHSFPFDKINEAFDVLHRGESLRSVINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7X5</accession>
    <name>A0A0N5B7X5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">6PF2K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7X5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7X5"/>
    <dbReference type="WBParaSite" id="SPAL_0000214900.1">
        <property type="protein sequence ID" value="SPAL_0000214900.1"/>
        <property type="gene ID" value="SPAL_0000214900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001979">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF70">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="252"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000214900.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56605" checksum="B48D222A2C3EE565" modified="2015-12-09" version="1">MPIDKMVPQRKMTFIQDPTSDSPNEQVRVPNVISLVGLPARGKTYISKKLCRYLNWIGIKTKAFNVGDYRRKVCNFQEQGKFDFFNPKNEDGVKIRDECAKMAMDDMGKYLENNEGEVAIFDATNTTRERRRWLVNYCASKEIKFRVFFIESICDDPDIINSNITEVKINSPDYKGIMSEEQAKEDFLKRIENYKKQYEPIDDDIDDDLSYIKVINAGRSFYVHNVVGHIQSRVVYFLMNIHLLPRSIYLTRHGESDYNRIGRLGGDSPLSPNGRLYAEKLKDYFDKENVPNLRIWTSQKIRAVQTANHLKDIGAHVEYWKCLDEIDAGICEGLTYEDFETRYPKQFQERDKDKYHYRYPSGESYEDLVARLEPVIMELERQSNVLVVSHQAVLRCILAYFDNKNREELPYLKIPLHTVIKLTPKAYSCQIEMFKFNIEAVDTYRAKPTIPTVISSKNIIEAAIDKVTNKTVADEEERHIITNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Z7</accession>
    <name>A0A0N5B7Z7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Z7"/>
    <dbReference type="WBParaSite" id="SPAL_0000217100.1">
        <property type="protein sequence ID" value="SPAL_0000217100.1"/>
        <property type="gene ID" value="SPAL_0000217100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF5">
        <property type="entry name" value="PROTEIN CBG13296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000217100.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31387" checksum="C9A0E0C5EF0105BA" modified="2015-12-09" version="1">MAKVEVQIRRCFCCGLTPGTFFSVLYTLLIFALLTGLGCWGLSDTVNNGDKSHYTSCELEAQGKIRADNRKLVFHEGTTKVIVEDSTSYHCSFGLYTEELKYEKNVRYITLLVDVFLWAALIVASILCLIGLAIYNEWLLIPWILLMLIEVIRGIISVVFIFIFSYGNLARIATGIFFLGVQFFHVSILMVMIAKFQRMYNRNRGIVMDADKQYVPDSSRIYPVNNTMLSSTPYGDNGYNNYSPSQHYNNTHPYNVHDHMDYGHPQPVYYHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B889</accession>
    <name>A0A0N5B889_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B889"/>
    <dbReference type="WBParaSite" id="SPAL_0000226200.1">
        <property type="protein sequence ID" value="SPAL_0000226200.1"/>
        <property type="gene ID" value="SPAL_0000226200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000031">
        <property type="entry name" value="PaTChed family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF6">
        <property type="entry name" value="PROTEIN PATCHED HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="643"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000226200.1"/>
        </source>
    </evidence>
    <sequence length="1365" mass="154034" checksum="C8139BC2CC10978D" modified="2015-12-09" version="1">MKVQPEDGSSSTGEETSNSIFKFLNRYLIGNSDTENYSEKWKEEFSYNPSWCDADLSLQLIHAGRAKGNTIALYARSFFQLILYKLGSFIQKNPIKILCFGFLLFTCFLGGLKNVTIETDIVKLWVSQGGRLDEELNFLSRVQREASKVVVRSGRAADQLNEALKNGNFSNVLSSLSLTNNSIKPIIGKKKDNVAAAPEIPKGNGLGGGFQVVIQTPDYKGENALTKEGLLKHVELMKEIAQYKVNMYGETWTLADICFKTPAPSFPPGPLSGALSTLLEKIIPCIWITPIDCFWDGSKPLGPFPELNLGDDISSFITSLPKGNITWKNLDPTAVIKEVENLFDLGGIGSLFERAGIDKAYLDRPCIDPLDHECPKAAPNYFDKCKALEKFNLWNNNKPMDEKVILEPEIFTKTNNSELNNIFSGLIGRKKRETVVEDNKNIPDSDNKTSKSRDDDYYTYDTDDDEKEAAAKAKVKKDKETECQTYSKSLLKWMNYNKNKWNLFLSPEDMPKYPDYGKIMTGGCYGFGKKIMKWPEDLIIGGVQRDEHNNIKKAEAFQSVFLVSGAHDVWLRYRDKKPDVKPNLDHSIWSRGVANDIVQAWQRNFTQNLYKHPLNTIENKKRVFHPLASTSIADMLEEFSEFKFIMILIGYLLMVVYAGFAQYDWNDFWFSHKSTAAISFIGVFIITYSSIAGLGLATYFGVQFNAATTQIVPFLTLGLGVDDMFLLLHNYNNLLKVSRNNEIGLLMKETGMSIFITSTNNILAFLSGTILPIPALRSFCAQSGILLSFNLITIIFFFPALITLDLRRRKQGFRDFSILFPCVNGDSEKNVKEDLDKFNNRKNHKIDVHVSLNHDAPIYTLVGLLEKVYLPFLTTKIAKVIIVTITAILMSLGIYGLTNSTLGLELSDVLPEHTAPAQFLKAREQYFSFYPMFVVLKGPNIDFPNQQTKIEALRQDIAKSDFVIKQDGQPSEPYWMSMMQTWLRALQKQLDETIKKGFIDVNTGVIKKGVKLENDIYIARKMVCSYGNKFNCTGRIGSVKLIDENNIINPEGFYNYLTAWYHADNMMYYVSQAAFFPNPPPWNFMDRQDKVIPPAKPLAYSQIPFYMTGLTDTPPIVKMIKEIRHICDNYTDQGLPNFPSGIAFTFWEQYLHLRWHLFLAICTIAGCVFVVVSVIIFNPWAATMVMLIVVSMCIELAGFMGIFGVKLNPVSAVTLITAVGIGVEFTAHVVLAFLTSLGSRNDRMVSCMRHMFIPVMHGALSTLLGIIMLAFSEFEFVVKYFFVVLTALILIGIFNGLAMLPVMLYFIGPPSEITPMDGSNRLIIPESFIRRGRKTQIASLQLPLDKEPKLESEMSEIKVTKTNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8H1</accession>
    <name>A0A0N5B8H1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8H1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8H1"/>
    <dbReference type="WBParaSite" id="SPAL_0000234400.1">
        <property type="protein sequence ID" value="SPAL_0000234400.1"/>
        <property type="gene ID" value="SPAL_0000234400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000234400.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="50320" checksum="9DCE46F5550EC36B" modified="2015-12-09" version="1">MNNDAIRFLSASGPLLGPGFSGFPSTNLMNPGAAAVAAQAVADANNFRAAFAANQAQTLQFPGLYPQLTPDMKQDMLATAVAGSGMPPYMFDPSIGFHPYGGGFDGGRRKNATRETTAPLKQWLNEHRKNPYPTKAEKIMLALLTKMSLTQVSTWFANARRRLKKENKMTWSPRNRTGEDDDDDLDDINPNERPSSSTSDLFDCSIKEETSIDETSTPINETTSPILKTEGQSPKKSKIWSIADTITSTPSSTSATSTSHNENKLVSSPKDSTSISLSSSNMPFPSGVFSNGFPHPLMSTANQALPNFPFPQNGFLQWQQQMAALAAMSRQMPMGIRPEMLQMMQAFPQMQGNNLFHNMMNSNAVAPQTSSSSTTSSIPTPSSSVPLDSTTTTALAAAVAAASKNDVSDESLSKVHTSVPVNINNFTSNDDKKENGKSTTSKPSSPECNTNSQKSEDNTTSNNENSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8P3</accession>
    <name>A0A0N5B8P3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8P3"/>
    <dbReference type="WBParaSite" id="SPAL_0000241600.1">
        <property type="protein sequence ID" value="SPAL_0000241600.1"/>
        <property type="gene ID" value="SPAL_0000241600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF108">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="290"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000241600.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="99771" checksum="705878D9E52B3382" modified="2015-12-09" version="1">MDKFMKNNNQLIVNVVTKYPIKCIIFSLLTTIVFSISLLNAKIERDIRKSFSSTNSKADIELLRYLDFYGFKDVPKRAFLLIQAKDGGSILRSNILKKVLEIDSRITNIIEKEEIIKGDEINNSNKSTINMNSKHQQKKTTACYPLCNLNQPFHLFLKTLIPVLGKEIRLNTEGNGTQYNVDKTSDTLTYPHFKLMGNDIFIGLNLFGVVTSNEMFPNNRSNIISAETIILWYVSRSDTMKRVKEFKNITLQLFSESSLYKNQKNDNEIIYEIYGDEIANHEMVRGAIEATILMIIGFILLFGFVTFVFYAQIHPKKYVIYLVIGAILSPFLAAISAFGILVWLGNDLYVIMCVTPFMILAIGVDDAFILTSSFVNSSHIKDKKAKIEKTLASAGPSIAITSITNTVAFGIGFFTPAKQMSLFCLCTSIAVLLDYILTFTLFLPILVLISSTKVENQKKSTKKIGFIKKYVNFLSSLKGKLILIFTMAIIYLISSYHAFNIRQTFVPSKAFPSDSHLVTSLESIRKIFDSHFPVSIFFSNPPNISNVNEYQRFYEMINKIENLDETYGRNKSLLLLDKYEEFDRKTHQIYNFLGIVDNNYTLNYDNMKYFINNILKTERIKFDENNNKLLKLHITVMAKNMSEWSKRAKFYEKIRNILNAYSEFNGTIFDADSGVLDMILNVKSDLLGSITVSIISMGVICLFFIPNYVGIILIVISLTSICYSKLNIGKLVSNFIFLDLVGFLAWWGSDLDIITIVDVLIASGLSVDYTAHIAHFYFSSKGNYKERLTYALSEISLPMINAGLSTFLCMFPLIFIQTYSILAFAKTIFIVVGLGLIHGLFVLPVMLVLAPLGNESNENIIIDQDSIKISSIQPFISSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8T3</accession>
    <name>A0A0N5B8T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aldolase_II domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8T3"/>
    <dbReference type="STRING" id="174720.A0A0N5B8T3"/>
    <dbReference type="WBParaSite" id="SPAL_0000245600.1">
        <property type="protein sequence ID" value="SPAL_0000245600.1"/>
        <property type="gene ID" value="SPAL_0000245600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000245600.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27333" checksum="672249D017205861" modified="2015-12-09" version="1">MDLNDTEDMTKEIFTQLMTQFYNLGWMYGSSGGMACCNSNEEVIYSPSSVQKERLTPNDVFIYSRQTNSISYRPKNENIKESACTPLFNYIINKTKYQCVIHTHSKYSNLLTQLIDKKSKIDGNFNRDEFCMNNQEMIKGIINRETEKNFSNLETIKIPIIENKPYEHQLLPDVAVSLEQYPTSCAILVRNHGFFAFGPTWQRTKIMLECCEYLFELACDMITNDIELIKISKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B948</accession>
    <name>A0A0N5B948_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrotrans_gag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B948"/>
    <dbReference type="WBParaSite" id="SPAL_0000256400.1">
        <property type="protein sequence ID" value="SPAL_0000256400.1"/>
        <property type="gene ID" value="SPAL_0000256400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000256400.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23068" checksum="7022B1AD039CAA9D" modified="2016-05-11" version="2">MESFGNGFFNETASSGAVELKNVLKLEDYKGTSYTGYLKKLFTMRRIPKEDFPIQAIMQQNAERQSEMLECMSEDPTWEEIEQYVEEYCMINAKTWQSELVDVLKMEKQWGETPREFFRRLERSAAMLIGRKDPKDVLLLFASRMPKSAHKYLLQVKDFSEASLIHAWTQSMEEKKLLISEGSRGNAAVNLSQEVKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9M7</accession>
    <name>A0A0N5B9M7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9M7"/>
    <dbReference type="STRING" id="174720.A0A0N5B9M7"/>
    <dbReference type="WBParaSite" id="SPAL_0000274300.1">
        <property type="protein sequence ID" value="SPAL_0000274300.1"/>
        <property type="gene ID" value="SPAL_0000274300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000274300.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27609" checksum="768B48D15D5CF198" modified="2015-12-09" version="1">MESLPVAVITGASSGIGRATAIYFAGKKYRLALCGRNEEALNECVEKCLKEGITKDQVTTTIGDLREEAVGKKLIENAVNVFGRIDVLVNAAGILVNGSVDSTPITEYDRQFDVNVRSIIVLTQFALPYIKKTKGSIVNVSSVAGTRSFPNAAYYCMSKAALDQFTKCLALEVAPDVRVNSVNPGVIVTDIHKRAGMDESTYAAFLEKCKSTHILGRAGEDIEVAKAIYFLASDMSSFTTGELLHVDGGRNLMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9R7</accession>
    <name>A0A0N5B9R7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9R7"/>
    <dbReference type="WBParaSite" id="SPAL_0000278300.1">
        <property type="protein sequence ID" value="SPAL_0000278300.1"/>
        <property type="gene ID" value="SPAL_0000278300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000278300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16618" checksum="2564F3EB422F1A8B" modified="2015-12-09" version="1">MYNKIYVIFLISYQLFIFIFPITDIERRKLHLIVQKGDMNKDYMLDKIEIKNIIKDLIRSVPKYYPGTSPSLDAIEGVHVLSEDVFKKYDKDNDEMLSYRGTLLRKSEAIMFGEVLEKIVINLLHEIAQLPTPYKNFNPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9W4</accession>
    <name>A0A0N5B9W4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9W4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9W4"/>
    <dbReference type="WBParaSite" id="SPAL_0000283400.2">
        <property type="protein sequence ID" value="SPAL_0000283400.2"/>
        <property type="gene ID" value="SPAL_0000283400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000283400.2"/>
        </source>
    </evidence>
    <sequence length="968" mass="112348" checksum="BC5B47585713C9AA" modified="2015-12-09" version="1">MFTYSPKIRWLETSNYEYILTTSKHIKLFYTVEENDKSEVKEKPIQIKRLPGDIICSSDICNELFAFGNNRGCVYLTDLEDPLHRIVDIRPEYSNIDDCLIRDIKFNRDDPNVIAVTADSLHSEHPGSIVNVYDLGEFCHDNEGLPCIYNASFGHRVLSLNWLDSNRYLVSSANQMEIYSRNCNDEVVEKLIVEESITNVVVEPNQGNALACYANGKIYIYDLRRFRQPIYIIDTEFSTHENKTKHFIELGWNKNSHYDLSILYKGYPLYSVTSFASSDFCTEKPLLKSRKSYGKHDPGHPYIVLPIPLHQDDDIVSFDWHPSKKHQLITLSSRKKIFIDSIDLRGTAQICPTSKVVCTSFDNEILIRESYINIESKGQFDSKSGKKKKVNMIKDINDIMRQRAIKGFGYGESDDPLLSCITKCLQIIENDNDISKAQKRDLLNVWIWLSRMTTRGVENEIVNDKYRSRFPGMIEIAENGMGRDVSYSVGPRIKIEPKQKDTSSHGTSSSSDEDEVVIKYRFFQHPRRRDILKICGWPTVDDVTSQEYLSLKFEQDFSELPRSLTIAAFSGNLDLAKELSSRFVSEIEARDDHAKYLEVLKELDKILQSGVGKKLNNYDMLSEVRFYNQYLMALLIFVSVRKSKDNEKFKEIFELEQITFLDKIAFASLFLTDLEFFQECERIKETMVKKAQLSALIMMGLYNDQEVHQLFHNYIDRTGDIQNAALLLIIGDCTEEEIIYFDKRSLMLKEGETGVKERQKSIVNPDLFLYEIYAKRNVERSLIIIRCYMDLLNSWSLYLNRTFLGCLSKNVRSLNFTKDINDHFVSPTGNPVQVSICCNFCKEPITKDKTKVTQCETDMKHLSLYKRKEKKEDGRSMSCKNCRKPLPKCSICRFHFGTPMHEDEKINDETNSDNWFTWCTNCLHGGHKKHIVNWFRVFDICPVSGCGCLCIMRDRNVYKNYTKYKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9X5</accession>
    <name>A0A0N5B9X5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9X5"/>
    <dbReference type="STRING" id="174720.A0A0N5B9X5"/>
    <dbReference type="WBParaSite" id="SPAL_0000284500.1">
        <property type="protein sequence ID" value="SPAL_0000284500.1"/>
        <property type="gene ID" value="SPAL_0000284500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="69"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000284500.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28594" checksum="0300E217430D9355" modified="2015-12-09" version="1">MTTLNKETLNNNFSCEINNSSSILNINPTANTTKSYDKTENKIVEEKEVKNKKGIEVLKRYREKLFTSKMDEIIPNLFVGSLRDSIDINQLAKNKIKRIVSLMSYFSKQNHPHHSNIKVLKIQIEDKCCEDILTFVPMINTFIHEGRMNNEAVLIHCFVGVSRSVTVAALYILSVTTISYNSVLSLISSKRLSASPNIGFLMQLRKFSLDLRDNEYRRLMLENEDNEESKEKFEELFKNDKKATSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA99</accession>
    <name>A0A0N5BA99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RAD51 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA99"/>
    <dbReference type="STRING" id="174720.A0A0N5BA99"/>
    <dbReference type="WBParaSite" id="SPAL_0000296900.1">
        <property type="protein sequence ID" value="SPAL_0000296900.1"/>
        <property type="gene ID" value="SPAL_0000296900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002052">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="5">
        <location>
            <begin position="122"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="6">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000296900.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40317" checksum="EBA4662A4E9EFDCD" modified="2015-12-09" version="1">MATHFSHRPKRAAAVEAEILISEGANERVEKDGDVMEEEDELDVGYQKIEVLEKYGIDTKDIQRLKSHGFFTVESLVYVTKKALVNLDQFSEDKVNKILRQARKLVNLTFTSASKILEQRENLIKIRTGSRSMDRLFGGGIETGSITEIFGEAGTGKTQLCHMLAVNCQLPADEGGGEGKCMWLDTEGSFRSERIFAISEALNLNYQCVLDNITYARVYNSEHQVEILGEAAALMSTSKYSLLIVDSIMALFRNDYRGRGELADRQCMLGKFLRHLLRLADEFGVAIVMTNQVTATVDGSVQMGAPEKTPVGGHILAHASTTRACFEKGKKGKRICKLYASPALPEGECIFKVGDAGIEDYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAY7</accession>
    <name>A0A0N5BAY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAY7"/>
    <dbReference type="WBParaSite" id="SPAL_0000320100.1">
        <property type="protein sequence ID" value="SPAL_0000320100.1"/>
        <property type="gene ID" value="SPAL_0000320100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000320100.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50401" checksum="B11526AC88B76A37" modified="2015-12-09" version="1">MCSVNNYLFYFNNTIESVLDSKTLDLYYMIHKCASHVQSIFNIQFFFVVLFNILNLYVLYSKRSRNRNNILSMFTAIADIAIVLSLMLIFNMHDCQTKESGSFLCSIFKLLAGNGNSYTSISLTTLSIISNTATMSSTWGVLVISIDRLRAIRHPFKIVRNGIFKDVCVVIIFIVLFTLASNLTRYWETKIVINTSVNYDNFVLQYETVDYLKIILNGVRIILHIVIPLVLLTVINSMLIFHLKNRSKYFEAAKWNPSKRSFDSGVSQNKNTDCLSQIWSRNNGYKEFKITIMMVLLITFHITSFLPTMLYHLYFEIIVPIMSYYFKINIDKMSYPIHCDNGEIITTRKNLAYLTITILVFGKISNCLLLCNLPNAMYKMCGTMLSQKSLTTSLTTKCENSVVRKVSRPIASSRKVTKQENKSLIMPLNNFNQTTYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBC5</accession>
    <name>A0A0N5BBC5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBC5"/>
    <dbReference type="STRING" id="174720.A0A0N5BBC5"/>
    <dbReference type="WBParaSite" id="SPAL_0000333300.1">
        <property type="protein sequence ID" value="SPAL_0000333300.1"/>
        <property type="gene ID" value="SPAL_0000333300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000333300.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39501" checksum="2E18D9FC2E44DDDB" modified="2015-12-09" version="1">MDEECDHVRLNTFQLLFIDSPNQKESLKVAGNLLLSTTKKMLQDTTKLPCIECLKCITSILLDFNNLKPIPVNIFKEEEWPKELGKVLERIVKTKNIEYNYIKLVFKIVPQLFYLSNDSWLQGNDKFLTLIVSLCEVRLRMVLGEYDKIEEKEIDDVCDVLEFVVREIENGNYMDSLATKLSLLIQKSISFLCEWIHEVYIEKLTINSKCEEKIYQTIVDFFSIGGAEMIETRTLKEAIEALQSISLRYLKEDISKGRSLVCILTNCPSLPDTTLKFLLEYYNTSPDDNYKSKALKDLSIILEEFKDRCDFYNISSLKELKRLSLEMNDIKIKEIIENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDN5</accession>
    <name>A0A0N5BDN5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Importin beta-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Karyopherin beta-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDN5"/>
    <dbReference type="STRING" id="174720.A0A0N5BDN5"/>
    <dbReference type="WBParaSite" id="SPAL_0000411800.1">
        <property type="protein sequence ID" value="SPAL_0000411800.1"/>
        <property type="gene ID" value="SPAL_0000411800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000411800.1"/>
        </source>
    </evidence>
    <sequence length="898" mass="102411" checksum="7C4DA83A9B4DBB40" modified="2015-12-09" version="1">MAWEPNEAELRQILGLLKQTNSGDTMVQRNVQAQLVSLSEHSQFCLYLAYIMADLKDLNEPIRSVSGLILKNILLKYYQFLPNEIKNYVKSKVCSIIGDPSSLIRATVGIVLTTIYTREEGQWNQVLHYLVKLLQNPDYNLLDGSLGTLQKICEDSASKMNEKDIEIIVRPCFKFFNYQIPKIRSTSLSVVNNILLFNSNVIGERFDEFIVELFKLANDNDGEVIKELCKCLTLICETFFDRIVPQLENIMQFMIHKTQDSNEEIALEACEFWLTVTDHAENDKNILGPILPQLLPVLLKSIRYSQEEIIALKGDIEDDSQVPDKEEDIKPRHYRSKNHHSLNNSSRIPEIEKAEALLEKNPNIDDDEDMEEDEDDDDTNWTLRKCAAATIDVITNIFGVDCLPILLPHLKELLHHKEWEIRESGILCLGAIAEGCMSGITPFMNDLFPYLMESLNSPKALVRSISCWTLSRYCNYICQDSSSPAFQLLVKGLLERMVDSNKNVQRSACSAFANVIEEVGRGLLPYFSDIVMTLTQCYKIYQARNSLILYDCTGTLADVMEEHLQNEFFLQSVMPLLIERWKQSTDCDRQFFPLLECISSVALSLKEKFIPYGRPVFERCISLVNNSLNNLQKFEGQDGCFTYIDREIIVVCFDLLAELTDVLGEGMEKFYEEVNIGFLIIKAATLGNDEVKQSTFALVGDICKKCPRFLLEYKHQIAAILVANITNNNTSLVNNAVWAFSVMILILKEEIEMYLSYTVPVLTTILNCHKLERTLSENTAIAIGKLSLFAAPKMASCLPNFIRPWCLSLRNVRDSEEKVVAFEGIICLIYLNPTGILGDFVFFCDAIGSWENPPEKLRSQITAILNRFKEQIGLPFWNEFLSHCPEILQQKLKIFYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDQ4</accession>
    <name>A0A0N5BDQ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDQ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000413700.1">
        <property type="protein sequence ID" value="SPAL_0000413700.1"/>
        <property type="gene ID" value="SPAL_0000413700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894219" evidence="4">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000413700.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29775" checksum="A0BE3E926CB2A646" modified="2015-12-09" version="1">MIIYNLFYTFICVILFKSSYSILLKNICPKNMVFKECGTPCPEKCFEGPRPCKRMCVLDVCQCRKNFVLNKHGVCVRKSQCKKGIKSPALIEDCPENTVFSVNASACPPMCYDGERPKYCAMMCYDGERPKYCASQKLQNVCECKEPYAYNILGDCVPRHECGAISLNRCYGEKIYSLCPDRYEKTCATLKKSLKSISCGEPRCICRPGFVNIRGDCYKASICEKLRKKRRRQTKKLEYLMKKLNKYLRQKKMYFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDS8</accession>
    <name>A0A0N5BDS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000416025.1">
        <property type="protein sequence ID" value="SPAL_0000416025.1"/>
        <property type="gene ID" value="SPAL_0000416025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894424" evidence="2">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000416025.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23669" checksum="CB7BA4CEFD792E13" modified="2015-12-09" version="1">MNFLLLILNLFLLLFLISISNGYNLDQSNVGNLKNYLYYNVEVAKRDINRFNDILDRIKRAKKKTTTTERPQDLESLDDRKHQETTKATEKKSNKKNESKGGKKKKNKTNNNNDSNQNLESLNSGEFQDLELGKGDFSNISSPGEGTGGNTSNKTIKKSKKKDKGSQKHKKNTSTVPTNSFESGGKQKASNTKQITFLLDTNTEINGSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEQ1</accession>
    <name>A0A0N5BEQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000447500.1">
        <property type="protein sequence ID" value="SPAL_0000447500.1"/>
        <property type="gene ID" value="SPAL_0000447500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000447500.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20416" checksum="8FDEBB05CD678B52" modified="2015-12-09" version="1">MQLQDANVDKGGFNNIVEVADGVSELVTDSGNNKKKVKMKTETVVTSKPWEGYIMDCDDEIRTREASWNIEKLAVEGVNKPKDEKHSYNEPNLLMGCRVQIRNHKDRSKFTSKYGLKHIISGKRKKSYFVKCIGKKGKLKLLHIGDTKFDAPVGDCVSAEGRSKSSNDLYLIGGTAASNFDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BER3</accession>
    <name>A0A0N5BER3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BER3"/>
    <dbReference type="WBParaSite" id="SPAL_0000448600.1">
        <property type="protein sequence ID" value="SPAL_0000448600.1"/>
        <property type="gene ID" value="SPAL_0000448600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000448600.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13095" checksum="2D03729DD99B62B0" modified="2015-12-09" version="1">MVQLIYTLRKLGNNSIPRIKADFLKEFQITENDFENATDLTFEQFIRLGAFSDLFTVEGENIVFKISRLKRRFTPNQDEEQNQHIQNEPDETSERREEPNEEYYSSNVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH37</accession>
    <name>A0A0N5BH37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BH37"/>
    <dbReference type="WBParaSite" id="SPAL_0000528200.1">
        <property type="protein sequence ID" value="SPAL_0000528200.1"/>
        <property type="gene ID" value="SPAL_0000528200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000528200.1"/>
        </source>
    </evidence>
    <sequence length="1549" mass="174280" checksum="93F98D91D6F01D57" modified="2015-12-09" version="1">MEVISTEIKDVNINGSKNNLSNDSISTGNSNEYGVLTPPNIMSRQKSSQNCQMTTTVATTSTSPYSQYQPSSAFVNAKLAAGSSEVIHVSKSISTSFCENQQQYIHNQNPKRITTSNNLVATNINSPYYQPSGGITSNSQSLGENDINTFQLTDSIDNSIKNNSYMPITRHYLTNQKSNLSKNINNTCQVQNNTCYQNNYKTIEKSPNFEYTYCDNSIKNVETSPLPHSSTPLSSISYSSSTENAPVASMNETEVTIKSKLSFMKVSELKSECKKRNISSNGSKTQLLERLQPYEDSILLLNKEENDQDNVKSMPSINIGNQQHSINQVSNTTEYYVTGPSNEYITKQYDSQNTCHSTNFSSHINHNSKRMSSHSGNVSSFNSIDGSDGMSGIVIRNNQLQEGHLDMKILNNETIKEEYIDNGNSNNESYYVEVPTFKVSNSQSPQQYVKLVNQTGTVVGISQLSKNTPTNIATSSNLYKYHNTTVGSGSSQNNGMIYYNQISQQGKQNNQDSNLINSQSGKYSYKTISNNVIKSSNSTLNHQTLTRVSSDSEIYQQNTLSQMYTTSSNNQENYIFTNTITPNYQSDNNILHNSPFSNSNDNLPLNTTTTILRNSPTKQPILNIKGNDNTNNKAQNSVSFVVLQQEPRQRSTVSRNLDSYRVMPNPQNSNSLSSYISNGERDERNNYTNQTYPVQENQKDLQKTIDHTDTTHYHMGVKHAALSSSIINNNINDTLKNFVFKSFPVGDINKSFQEISSEVKKIFSQNGKNCMEKNEPIMTAEIMHVHEDMIQQQFTTINNLYNKLLNSQYQLKNYQNILIAANNFDVESIQRREKIYPTLSCLKELDTRSINRKYMKLYSNYENIYHNLKDGVKEHQTIVDNEEVLQDLAHVTQATEDIVRLIKQDSRTALLIVQLLRNFQVERSQCASRRNSFNVLLCEESDSKNLNEQRKDQRHLETGFFKGQPNCNQNDLFTRSDNQINGIDRSYQSNIKETKSGKDKIGVNTKNTSIYSNVDNTNSTMSGSQKNSNNKKNGRVINKAEPKTPNKAVSRRRAPKNTNKAKDEEKIVNDMSKAKKSTSSGKINDMEEIFKTVIKESSKCVTAIESKERAEETINEYVKNPPNSSPSTNNNINGINYTTTVMTNSSSVQSQIQQSNNNGTQVILINKDPQYGTQQQRNGGKKRVNTQSIQKQNNIQQKSPKVQQCAASLVDTIPQHIQIQHSSPILHQHLQPNSVEAMDNVSSQQYHYQTYQNDQNNHFSPVNVTTNCINGQFIQQQDHNQQYNNILNNNQISSTTFYAIPTNTITMTNQSTITNQGNGGNIVYHISDGHHQSQPQYSIINNTIDDNTNYTFATTTLQSSDNFSSSQIDQNGMIHDNTSTHWITSTQPTSHHQQNICNTSMDNTGTLDISTDSGIQHNISSVDINSSKSGDEINVLLDDSWYNNNQHRMYDSIQNNSQHSTNNNNRKSQTPSNTTTTSSSSSSTIIPTTTSSLDGSNIRNTIYSNSQSNNNMLGYNPNFSDSDSFNFDNNDINQQGDQNMDWVDQQLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH86</accession>
    <name>A0A0N5BH86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH86"/>
    <dbReference type="WBParaSite" id="SPAL_0000533100.1">
        <property type="protein sequence ID" value="SPAL_0000533100.1"/>
        <property type="gene ID" value="SPAL_0000533100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000533100.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38067" checksum="38AFE186AF300931" modified="2015-12-09" version="1">MFNNLLDELFQAQKDNIKENIQPEENDLSFAEEDNENSFLNISDPIEPSAKKVKIDKETFATRLPDTQRRYFKKLKETIISDGYDQIICQEAFDYLAKSFKVKYTPIETKLSTEDCLMLQITCGLSKNKILKIKSIIEKTIGAKIFPTVDEINNSWMEIKEDSEVKAFTLHSVKINNKIHILDGADDCNISNSNEIYGCYNSNIKKDLISRYETLVRSGKIDENKQAIDICITGDTGSNTTKICAFFKTTSSTNAHSNLLPLSIYKGSGAKNVLRKIASMFVDQINGLNELPIFSKNVKINWFLVADMKFIYNIMGNKTAFSKRPSPYCDKFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHK8</accession>
    <name>A0A0N5BHK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHK8"/>
    <dbReference type="STRING" id="174720.A0A0N5BHK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000544600.1">
        <property type="protein sequence ID" value="SPAL_0000544600.1"/>
        <property type="gene ID" value="SPAL_0000544600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000544600.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56525" checksum="5585E41F9FA3ADA8" modified="2015-12-09" version="1">MANFDAIFTIRSKQWKDEQRLLSVGRIPTKEEKERLIKAQMDELTELMALCEIPEGRSAVLPVIWDTRKADPLQDELSRTILGYIQKGVVLQPFTKGSDTDFNKWKDKLLNMLSGITATDYSFGLACEVCVKFIDIFIPESSDAYRFLTQVRPMFSDETGKLKVGTQLPALLEAVYLQMRSSATKSRTQMLAKRPYWDRRTDNMVKFIKKYEKYLQQRFDVTSIDAYLNDNPALMRSEVMNFCDAVPHIIRKEARIELGRDWRWNEFTNHFTEAESSLAYHNPNYKINKGDEAIDIDKTSDKYKHDNNKSHNNNRHKNNYNKDKKDNNYDKNRQKGKNNYTKHNGNKNNHGNGGNRERNNAKSNNNNSNNNYKNNSKTYIKGKGTKNGKQHSGTVQVNSVEEASMADYVNKLVLTSLANAKYNMTLMMACIMLILLPMTSATLPPSYEVEPCDQPMAPAFYALAKWDAKTATAAQFRVIPPACFPVGRYEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHT9</accession>
    <name>A0A0N5BHT9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab proteins geranylgeranyltransferase component A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHT9"/>
    <dbReference type="STRING" id="174720.A0A0N5BHT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000552400.1">
        <property type="protein sequence ID" value="SPAL_0000552400.1"/>
        <property type="gene ID" value="SPAL_0000552400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000003">
        <property type="entry name" value="Rab proteins geranylgeranyltransferase component A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001738">
        <property type="entry name" value="Rab_escort"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016550">
        <property type="entry name" value="Rab_ger_ger_transf_A_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000552400.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="58206" checksum="95DC6707B449DB7B" modified="2015-12-09" version="1">MNYLLPETVDVVVLGTGLPESMLAAACSRSGLTVLTIDRNSFYGSSWASFNFNSLEKWATSENCKKESTDVDVTLEEGEIFIPLVNDYLKDGINNITMNVEDKSDTNEITNLQKLQKDSRKFSIDLNPKLLLSLGQMVSILCDSEVSKYVEFVNAERLLCLKDVTSDAKSYRSFITKVPCSKADIFKTTSITMLEKRILMKFMTEVLNWHFHREEHEWKNILEGNFDELLEHQKVGEPLKKYIMDLIAVLRDSDKTGDCLDAISRFLISIGRYGNSPFLYPLYGVGELPQGFSRLSAVYGGTFCLDNDIDGFVIKDNEIVYVVAGGQKIKCKTVIGNGSYVPNKYFKKDATEEVVERIIVISEKSITDPEEEGTESKVGVINLASINNGVRCCLIETGFHGQTTPKGYYISHISSDKFSETFTNESLDKLYIKSEDDPTSSIIMKLQFSITKIDKLINSNELPSNFYVTPTTDSELDFRSIISQCKSLFKEIYPECDFLPEKLITPEDDTTQYNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIA0</accession>
    <name>A0A0N5BIA0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIA0"/>
    <dbReference type="WBParaSite" id="SPAL_0000568400.1">
        <property type="protein sequence ID" value="SPAL_0000568400.1"/>
        <property type="gene ID" value="SPAL_0000568400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000568400.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29867" checksum="70EAD5FEB819B302" modified="2015-12-09" version="1">MSNLTPCLYCHRLYSKYSLNLHQPKCFDNPNSKIQEDINNLQNKNFTLPNINDKNGKRRKKTPLNRSKSSSSNENKNSKKPNSYVNIYINNNGRRFSNGDNERSVIVKNSTSSADFTQEVIEKLQAIVINESTENILDRPGTQTLYSSQENCENHLMCFICGIFCESHIIKTHQEQCLIIWETIQKQLPLYIRSTPPKIVNVPSVDGTINITRHNQLAEASYKKCQKTKCNRCGKSFNFSEVLNHECQRFEPNFELYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIA8</accession>
    <name>A0A0N5BIA8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="6">2.4.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Core 1 O-glycan T-synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Core 1 beta1,3-galactosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIA8"/>
    <dbReference type="STRING" id="174720.A0A0N5BIA8"/>
    <dbReference type="WBParaSite" id="SPAL_0000569200.1">
        <property type="protein sequence ID" value="SPAL_0000569200.1"/>
        <property type="gene ID" value="SPAL_0000569200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000017">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="24">
        <location>
            <begin position="104"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000569200.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48258" checksum="09C022B3CB9A52BD" modified="2015-12-09" version="1">MRSSRKYQPLIILCIGVLIGILIGMMLTVNDGMVYVPTSLEEIEKKFSSDGEKQITGQGGYIDDGSVKTDDKESPESIFRFHLNESIHEKSKLNLPQLLAKKVRIFCWVLTGKQNHQKRAVHVKATWLKRCNNYVFMSSEDDPSLPAINLNISEGRNHLWGKTKAAFKYLYDNHYNDYDWFIKADDDTFVVVENLRFMLLSHSPFEPIYFGCKFKPFTKQGYMSGGAGYIMSREALRKFITEGLNDPKKCKQGESGAEDAEMGKCLEKIGVKAGDSRDDLGQHRFLPFGPTSHLVMKQTNPKFWFWRYMYYPIKQGESCCSDYAISFHYINANAMYELEYLIYHLKPFGVISSLAEKFILEGREDKINEIEKKMLTTAYEMSILTEGKDDFFPKTLDDLDKLISKKLYPDSKESNLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIM9</accession>
    <name>A0A0N5BIM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIM9"/>
    <dbReference type="STRING" id="174720.A0A0N5BIM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000580900.1">
        <property type="protein sequence ID" value="SPAL_0000580900.1"/>
        <property type="gene ID" value="SPAL_0000580900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000580900.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="89572" checksum="2119AC4A77DE661D" modified="2015-12-09" version="1">YTGELDQTKPFSELSGVPLEQHVEKIPSGYYDKLIQKEETPVIDDEKESKEPKESLLEKGKHLKDDIFGMFQKKYQDYPVSEPYTGEIDSTSRKNDLDQEPLNSCVSKYDIGYYSTVSKFSDVPIKTKKEFNDRTYNVEISNDVYNSGLSNEHCNVDSILLTKNNQLISSLNFNDQENNLTNKEGNNYSENLEIDGMPMEPRLIDNKIYHKKEQLSVYLTTPIADSKTIDIRKQKNIDESKFIRNKTDKSPQSTYKEGYSSTRFNHSDNIMKITDSFSSFQNVHQSNKSEKNKEFINNDMISDLKFSNYYNSKEKSSSSPPKRHVEFTSTYTDSIPLTKSPTNETTEPHTSHLYKSKQQGISIDPKSLKIVSKDDSPILFSERSSYYDTSIPSTSVVKNQSDISYSYLLPTTVEYSNLHNNLHPSRSLSPSFEVYLRKYDAKMRNRELVNIKPLASSTPIRNIENGNVYKLPSTDNTSFKKFVETYDRGSSENKHRRHKGWTTITQTTTITYSKRLNSTINRNGQNQTTATENVVISNLNSPYDNKNYMSSLETGKAIHDHITGSPPRIFERDENRRDIMLQTDPSYKGPLNHPINYSRLYHRSRSESRPQCFVTKNKFNNNRNGRSIERYHESSSIVPENHQIKRRFEYEQAVRNSPIELSGDSDHKTRASTEPLYSMQRIQRYDLDFPSSIPPPSSLHYQNSGLVERDKSLNNLYLDLPPIEEIGKTSFEQRYSFTTDVPIDNDFKTETENNRTTNAPLRRARTNVKHYCNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIN2</accession>
    <name>A0A0N5BIN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000581200.1">
        <property type="protein sequence ID" value="SPAL_0000581200.1"/>
        <property type="gene ID" value="SPAL_0000581200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000581200.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21361" checksum="AAB74861CCE8F9C4" modified="2015-12-09" version="1">MLNPDISNPVLIDFGSCYDHEANIPFNSISGTHDFSGLFLHNLTNGSIYDDITSLYFNCFTWATGEKFPWQNDNQLLKTPNYYIEERVRFLNRGYEPFQNSSINVKSKEILEVIHDAVINKESDYMAIKNKISQVYFYNSLVLSLSKDFKNLSLDREVIFDDNYLRNIPSDNFALLCSFQGNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJC2</accession>
    <name>A0A0N5BJC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJC2"/>
    <dbReference type="STRING" id="174720.A0A0N5BJC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000604800.1">
        <property type="protein sequence ID" value="SPAL_0000604800.1"/>
        <property type="gene ID" value="SPAL_0000604800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1940:FF:000002">
        <property type="entry name" value="PHAryngeal gland Toxin-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF15">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894376" evidence="4">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000604800.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="25788" checksum="4C6C1DFCF2E22D4E" modified="2015-12-09" version="1">MTSIKLIFVLTIFFTKCSIIKAAPGSPCTTKNDCGAGYSCVMLTSGNTFTNLCIQSCSSNTDCNGGTCSANPFGDPNDTTDKMCSTAITPNCITGQNAECVGDQKICSSYDLTCRLSKLNEICSSNVNCITGLTCQSGKCQTVTTTAKALTTTPVTCVDLVASGPNDCQLLASYCKNALYLSLMKEKCPKTCGFCSASVSTTTKAACADLSNSNGSSDCTKNAYLCTNSIYKSLMKTQCPKTCGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJW8</accession>
    <name>A0A0N5BJW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJW8"/>
    <dbReference type="STRING" id="174720.A0A0N5BJW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000623500.1">
        <property type="protein sequence ID" value="SPAL_0000623500.1"/>
        <property type="gene ID" value="SPAL_0000623500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000623500.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29333" checksum="0469E70536C939CC" modified="2015-12-09" version="1">MRLVIEKFLCEGSCSGVLISHRHVITAAHCILNNENSPYKYYDKNIVYDSEIVIGNFCNANTYVDGECINKEKVQKRGINRLLYNFKNGHRRYRNDIAVIELDVPVTGVTHVCLPFLHDDYKFDKSKTLIAFGFGTTKKGPSVTNAKFHNRLKRFIYTMPDSIANCSKLSAPVNSTESLCLGVNIHLGMCPGDSGGGLIQKTSDNRYILIGENSRSSSCIHKESTDMGIEKSNTFVLVEEYKDEILNFMHETKTYYFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK97</accession>
    <name>A0A0N5BK97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK97"/>
    <dbReference type="WBParaSite" id="SPAL_0000635850.1">
        <property type="protein sequence ID" value="SPAL_0000635850.1"/>
        <property type="gene ID" value="SPAL_0000635850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052860">
        <property type="entry name" value="NRL-GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521:SF7">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000635850.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39885" checksum="FBA1E0D3306D8684" modified="2015-12-09" version="1">MNSIDFTLIPIKVPIVEICGNVLALIFLILFFKHLIFQKHYHLNIRIFMIGLLIYSVFIIIARFLIFLGLMEGKFFLSTNLGSEKYCLVSFFTLRIGSLGYNSIFYIITAERIIASVRYKTYENEKSAILCIGVLLVQFLGIFMTIFVSVDRTPESQNNQLLIPCLVQKITGKTLSVLTTTFYILNILCFLAYIILIIVNNRLYKWSSSNSLGNILSMKYQILENLQFLNAFLPCIITYLIASIATSIIVLYYWSLLEKQNRSREDIFYGIEIIQLSDIVSTISFIIIPLITNYKLDNLVRFSRKKGNKISPSKTKSTENMNVNGKLTKLNENEVYFEQFKKQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKT4</accession>
    <name>A0A0N5BKT4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKT4"/>
    <dbReference type="STRING" id="174720.A0A0N5BKT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000653900.1">
        <property type="protein sequence ID" value="SPAL_0000653900.1"/>
        <property type="gene ID" value="SPAL_0000653900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="34"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="246"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000653900.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55693" checksum="4B3E755C11952544" modified="2015-12-09" version="1">MTNGMGFVVQRTFYVVSYFFLLLNLVNSIDMTIKLYRDLLRDYEPDVRPSIRHDMPINVTFTFTLTQLIDVDEKNQIITTNGWINQMWNDYKLVWDPRKYDNITQIHIAYDKLWKPDIILYNNADSEYTKSIISTNLIVNYQGNVTWISAGIFKSSCPLDVRYYPFDSQNCYLKFASWAYDGTKIDILLSNNSGGQSYYITSTEWHLNLVEAEKQITFYSCCDEAYPYIDIMISIQRRPLFYIFNLILPCVLISIIALLGFYMPSDSGEKVTLGITSLLSTTVFLMLVAEGMPPTSEALPLIGIYYGVTIFIVSLATTMTVFTLNIHHNGFQGKEVPSLLQYIAFKILAPIMLLRVNKYHSVTHHVKWFYNKYKKEELLSESNPYPQPKRKVNVPHFIPSSNNEESFEDDFICVLERLHAAMERNEFRLAEKDIRNTRQLEWQQVALVLDRFFLLLFMFGTLIISMAILFQRQIVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLI4</accession>
    <name>A0A0N5BLI4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLI4"/>
    <dbReference type="STRING" id="174720.A0A0N5BLI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000678000.1">
        <property type="protein sequence ID" value="SPAL_0000678000.1"/>
        <property type="gene ID" value="SPAL_0000678000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000678000.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56659" checksum="393BE9448C981DC4" modified="2015-12-09" version="1">MSCKIGVHNNGFERSISNLKEDVQIDNAKDNNITIVTEEKIGQNKKYTGWRAYIVIGVLFIINMLNYMDRYTVAGVLTQIQAFYSLNDSEGGLLQTIFIVFYMVFAPLAGFLGDRYNRKYIITIGITIWIVAVFASSFIPQNSFIAFLMLRGVVGIGEASYAIIAPTLIADLFTEQMRSKSLMIFYFATPVGSGLGYIVGSAVANAANNWQWGVRVTPFFGIICVLMIVFVIKEPERGLAEKDEKNASAFEGKNTSYWKDLKYLAKSKTYIFATIGSATITFVTGTLSFWAPTAIEYFYATKYHYKTLKDIPNDTKDNISFLFGLITCIGGIVGVTLGSLIAMWWKNGYYCFPKSDKSDALVCTVASVLAVPFLFLIFELMSVELIFTWITIFVTVLLVCVNTAILVDMTLCIIVPKRRSVANAFQIMISHLFGDASGPYIVGLVSDWIRGSDDTPNGHFRSLKYAFYVPNVILIISVVSFFLASVYIVNDKKKYEKEIGTIKETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLV3</accession>
    <name>A0A0N5BLV3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLV3"/>
    <dbReference type="WBParaSite" id="SPAL_0000689900.1">
        <property type="protein sequence ID" value="SPAL_0000689900.1"/>
        <property type="gene ID" value="SPAL_0000689900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000689900.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41199" checksum="79C99C037A0F1692" modified="2015-12-09" version="1">MVIQDQNENSHDPRNPSKTQMEVRPVSNIPSIELTSETEVSSSPNPSSRNNSTDGEDDNRLFLKIDEGYSRKGSSLSYDAVGYHSDAVTSISNQSSPPYSSSSENSPTQRQDLLNPVFNSNPVPEKHNFIGKGGSFNIFKSDNLLCPFGNSRRNSGINDDDGPESSFCQVPIKIASLGFVFSTLIMVVLLISYILFQIKHSSIAHNIESNEYAKLTFCILLIGVIYLIFSSFYVYGISVDKKKYLLPLIFATISFCVALTGATLSFIISTASEINEELTKQEIEHNAILEIERKLFLSSSDDGIQHLPLHPIKHGQNRISDIILQRVILVCIIIYQIFTVICYYKTYKYIEKFQRKDCHQSTHEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNI5</accession>
    <name>A0A0N5BNI5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rac GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNI5"/>
    <dbReference type="STRING" id="174720.A0A0N5BNI5"/>
    <dbReference type="WBParaSite" id="SPAL_0000746400.1">
        <property type="protein sequence ID" value="SPAL_0000746400.1"/>
        <property type="gene ID" value="SPAL_0000746400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="296"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000746400.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="58033" checksum="83022C9A54C4798D" modified="2015-12-09" version="1">MLRIELELKEKYMSEINKRFSTKDSYLLDSREQIKILQTQKNELEEKINRLTRVFKVMEKNTKKMACYNNSPLSLKSNITQKENIEEKNNLILENKSFEEYYDDFSLPNWFYEETSTVDNEKNTISTLTQSGKSHEQNRFAYVNDAKKMSNSSIFSVLKSECSNTKNNRLQSPEPKHHVSFIANPVYCHKNGDNVTSNQIKTSILCNRSINTPDFVSIKDGWIKNLNSISSRLHSFNNINYPSECCEYCKKSFNSSKAVSKCDDCGVICHSSCTIKVPTPCVPRNIFYKYGSKIKLSFPNICPQTFPMIPYIVVHCIIALEKYYPTIKNLYELPESKLEVSKLYNTFLYSHTIPILENFAAPTIVGCLLKFLRAFSDPIIPHFLWEKFEAAIHKINKDTLVSVIYDLPKPNLNTLAFLCLHWKRVAEKSYPNIKVGIYNISNAIAPTVVGFKTSPEIISLDQMEKEMESQKLLMLGLLQLSDAFWKQILSCPTDNITYRNQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNL9</accession>
    <name>A0A0N5BNL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNL9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNL9"/>
    <dbReference type="WBParaSite" id="SPAL_0000749700.1">
        <property type="protein sequence ID" value="SPAL_0000749700.1"/>
        <property type="gene ID" value="SPAL_0000749700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050976">
        <property type="entry name" value="Snaclec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991:SF40">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="185"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000749700.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35030" checksum="4A28E2FC23B2CC80" modified="2015-12-09" version="1">MKSLQLLVLKSFLYSFFIWITLIQSYALKNLEDTGCPSENYTLKEDQQCYKLYNETSSREDAAKLCGKDNAYLPSIDNDGAQQVIINLLNNTKDNFWLGLKCTNDTYCLWDDGHNLGEYRNFLDDTVNADVGGCYYVKADPSSTKNGEWIPISCENQLRNYVICQQASTTDEICRCPENYLRNAANNDCYRYVSTLMTFNRANENCENDGSTLVTINSNEENTYVLNLVLNKEETNNIWIGLTYVNNTLQWVDGSPVNEWTNFKDGYPNNDSGNSTIMLVGEGDDNSKWINVNSSVEYASICRFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNM9</accession>
    <name>A0A0N5BNM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L51_S25_CI-B8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNM9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000750600.1">
        <property type="protein sequence ID" value="SPAL_0000750600.1"/>
        <property type="gene ID" value="SPAL_0000750600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750600.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19803" checksum="1F6BDAB8DCDA822B" modified="2015-12-09" version="1">MSQLYMIPSNAITASKIIFVPYFKTLKIGWQYNSLMCQGVEKFVEEFLPEIRKNNPDVKFVLQRTHTPADPFVVGEYDWNRHRAKRVGWRTEYQILSIVEEFALGGDYRSGKRRGVKPRLPRGQEIWDRETMGHDIFKIVSKYKYDENIDGKLPKTIDHKHLLHKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNN0</accession>
    <name>A0A0N5BNN0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNN0"/>
    <dbReference type="STRING" id="174720.A0A0N5BNN0"/>
    <dbReference type="WBParaSite" id="SPAL_0000750700.1">
        <property type="protein sequence ID" value="SPAL_0000750700.1"/>
        <property type="gene ID" value="SPAL_0000750700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="84"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750700.1"/>
        </source>
    </evidence>
    <sequence length="862" mass="100301" checksum="D43F3E3C937B0F31" modified="2015-12-09" version="1">MPVVGSYVSHVDTHSSSSTITSQNSDLVRVNEESHTHRVESFNRHHNIELLKMERWKNFYYWNPLDNKWRSHEDCRNLPPEDIEKQSAIREFIGTEKNHCEVLILLLQCYHINLKEQKIFINDGDVNLVTQITMNTLIDFHLDFLLSLKQRMEEGVCIGEISDIVLDRFSDQKNMLKVLVSYTELCSSLEEMKRLYDVTIKKNAKFSAYCARLNADPHFKGRDYKSCLDLLAQRCTKYPLLLERIIKLEKNSELLGRASASAIAMRKFTSTIDENLKKCELNRDWESIRQKIDRNDFGIFDGDPFTLQDLIYQDPNDPRKVICISQAYFKPRGSHSPVKLLVILFDDIIVLFVMKHNNMYFFNFDNHQAVYCIKKTSLRPIERRDAFALIYNCQVHMDMLTIEFDSKSSMISLGKIFSEAKEKLEDIEKVESGNCGVLTYRRCSSANKGTCYANFEDTFGLDTETFKKYNLWWSRMETLFDDKKADDLMMLKYIQDRTVWYKDLKNHIAQMPFARNKQVSQKTVDAIINKFNDLNRIKIYDNAGYLECIRQLEMEDCKSLFDCWNNIFFNDNEANDIFKAKSVKRVSTYNGEEDKSFSKEILPYNRRHTVVFNAPEYDVKAVESQCDFSTFAAVRGDASRRATEKLLNENASMRAEIIRLRSDLASMTAQVESMKALKNLDIFLTSTKSEESTNKETKLTERKSISNDRLFTLGREFFGRNEELVQKKQGKLDGREKESKKSHYIRIDKDLSNLSACVNSSGKELPDTPDSSDFYNLPGAGCYATKISQTVDSTKEDGTIFQWPKPMPKEDSPKMDSLFSKQVSRSKSFFSFHNDNKSFLNTSNRSYQKNKENIFKINNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP01</accession>
    <name>A0A0N5BP01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YqaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP01"/>
    <dbReference type="STRING" id="174720.A0A0N5BP01"/>
    <dbReference type="WBParaSite" id="SPAL_0000763000.1">
        <property type="protein sequence ID" value="SPAL_0000763000.1"/>
        <property type="gene ID" value="SPAL_0000763000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000763000.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25124" checksum="D2D17DCE1B769669" modified="2015-12-09" version="1">MENIHFSDICGKHWEAFNAIEETEFGVSLLSSDVTFKIGTTLDTTLDSTFSENILEIVKNLSSLLNIKGSLDSGKFSDNTMSSRNYNRKKYNLRCIIEAIAGVMVPNSKELIIGSFKDYPYGKSYRIQEEKILDISENIIEVYNNSESKVQLLSTCMPYNQVVQYFNKISRCAYTQSKYFAASINDMKKRKRLERYDKEVVKNFVSFISTPSRTTVIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPB6</accession>
    <name>A0A0N5BPB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BPB6"/>
    <dbReference type="WBParaSite" id="SPAL_0000774200.1">
        <property type="protein sequence ID" value="SPAL_0000774200.1"/>
        <property type="gene ID" value="SPAL_0000774200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000774200.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23794" checksum="A03CEE3E65866866" modified="2015-12-09" version="1">XRSNGGIEHGRSDVGGDEVVSSCEGACRQKYSRKQRTRRPTLKLLTYNLKEGLQKEQRIVSLYKELDKTTYDIIGVCETHLREVKYQRWINGDEHHFGASEINEETKSNIGGVGFIIKAELAKTVTKVEIVSPRIAVLEMKVKRQPKPLRIIQVYAPHSGYEEEAIERFYEEIEELMKTPTYKTIVMRDYNAKVGIAKEEEKHVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQP3</accession>
    <name>A0A0N5BQP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BQP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000820500.1">
        <property type="protein sequence ID" value="SPAL_0000820500.1"/>
        <property type="gene ID" value="SPAL_0000820500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000103">
        <property type="entry name" value="Hypothetical LOC496748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="111"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="200"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000820500.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="48151" checksum="0B7CB125B91B5E54" modified="2015-12-09" version="1">MKESYYFTSDLSQSDGFNDTQFKNVKIHQFYGKKVETKKSNFKLYLLFCLSVFLVTSLVVKLIRIFPITNSSVIEKSSSISLMCDFNIPKDEQLILYGRTNNKEREFICQFLNFLNDFNKTYETIEEKKSRFENFLKNIEIMNEKDNVDDSVTFKINKYSDWSDEELKKLLMSDEEIQHMDTLPYTEDFYYDTEFLNNENKSNFDWRDRNVITPVKDQGKCGSCAFFANVAVIESVNAIKGRPLTRLSEQELLDCDTKDNGCDGANRVNIFQYAEAHGVVHENYYQYRGVQSECRNMTGRPRVYIHGYKYLGRNEDSWINYLENHGPFSVGVQVPKQMYYYSSGVFNPTEEDCKQKSMGSHAMAVIGYGEENGQKYWLLKNSWGQGYGFDNGFIKMKRGVNSCGIANYAYGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQX6</accession>
    <name>A0A0N5BQX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQX6"/>
    <dbReference type="WBParaSite" id="SPAL_0000828400.1">
        <property type="protein sequence ID" value="SPAL_0000828400.1"/>
        <property type="gene ID" value="SPAL_0000828400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894888" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000828400.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14050" checksum="D1A48D1AFF13D33A" modified="2015-12-09" version="1">MHFIKYFTILVLLAVQYSFQDDTTTYATTPGCMYDCGFDTTQGALSDSVTRKKRSSIKEKLVRAPTDYVYRKKRSSFKEGLKTVKAKAEKLAKKATDGAVKAFDKTKNAAEKMVDKANLAARKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR11</accession>
    <name>A0A0N5BR11_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR11"/>
    <dbReference type="STRING" id="174720.A0A0N5BR11"/>
    <dbReference type="WBParaSite" id="SPAL_0000831700.1">
        <property type="protein sequence ID" value="SPAL_0000831700.1"/>
        <property type="gene ID" value="SPAL_0000831700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="57"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000831700.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44020" checksum="9A110113130F580E" modified="2015-12-09" version="1">MVHFSNFKDDAVFNNLDIFTNTSINQEEVEKDVSEAFIDYLNFTEISEEELADKAKFFRQSHAQFAIKQLSWLSSSASSMESSRTWFCFWGVHTLRLLNYPISDKLAHNVITFIKSCHNKDGGFGGSSGQISHLAPTYGAIMALLEIGTEEAYYCIDRKAIFNFIKSLSVGDGSFYMHVGGEIDMRAAYCAISVASILNLDMDELFKGTAVWIRDSQTFEGGFGGLPDVEAHGGYTYCAVASLALLGKLDTIDLTTLSCWLQLKQMPYEGGFCGRTNKLVDSCYSFWQGAIFSILKNFTLIEPNFIYPELDAKALQAFTLFISQDPLGGLKDKPGKHCDLYHTCYSLSGLSIAQHYNSEDKIIGGESCLVENIDPHYNLSLKYAEKAILYFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRQ8</accession>
    <name>A0A0N5BRQ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SF4 helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRQ8"/>
    <dbReference type="WBParaSite" id="SPAL_0000855300.1">
        <property type="protein sequence ID" value="SPAL_0000855300.1"/>
        <property type="gene ID" value="SPAL_0000855300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="2">
        <location>
            <begin position="445"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000855300.1"/>
        </source>
    </evidence>
    <sequence length="724" mass="83665" checksum="E6787A0085E5324A" modified="2015-12-09" version="1">MIPNSIRKSALLNSLRYFNITADSHSSRKNALLKYNTPVNTSCTSISKYSNTTDINKSRFLNQEPFPVNGDSKESQQNIKEKSLNTGSKYSNSVIVSHLTATDIKVDLEKYYIPIKNSLEVRKRAFERLSDHKSPGILLSIDQLDSDLYDSVSYNDLLIEQEENFKKIEESKKILLKTTKKPDKKKRSKDKVNESVSKDEEDYYSDPTILKIWNESQEIPDTLDYNVNLRFKLFNKYLGIDRLSPSTLRKCNVRTHINKKDELALIYPRYRNSRSPTKPIGIKIIRQTVDGKLTKENYPLKENKHSGIFCHHLITEDNKEVILTTNERDAMAINEAKCSFIALSLPKGHILDYSIMPYLERFEKIYLWFPEKQQRHAKDLAIVLNIERCTIILEKNRPIELLRYGMIEDIKDVITNASKKPTVNNFKSLKDLRKDVKIELENNAEKVRGFANWVRFDPLNNYLGGLRPSEVTVLTGGSGYGKTTFICEYAIDLFTQGVRTLMCSFEMNEEKIMKWMLVQYASLPLYRDEHHSKIDIWLDRFEKRQLYLMFLKSSTLRDKDINEIFSILKENIIQCGIQHLVIDNLQFLIGLSTLNNERSTSMDKFNLQDRFIGLLRRLATDCGIHVTLVVHPRKIPGEAKVELQDVGGSGKITQEADNVIAIIRKTHPTDPAIVKKFLVILKNRYGGRRTTAEQLEMIYQASTYTHVLIDHNKVEQEDISSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSB1</accession>
    <name>A0A0N5BSB1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSB1"/>
    <dbReference type="WBParaSite" id="SPAL_0000875500.1">
        <property type="protein sequence ID" value="SPAL_0000875500.1"/>
        <property type="gene ID" value="SPAL_0000875500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894802" evidence="2">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000875500.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36131" checksum="613E830A6BA49E61" modified="2015-12-09" version="1">MIEVLFFVTTILFAFFSCSQDGRGSKNRVPGNLLLTSNFDKKTRHSSGLPSNKISQNVKKAYKQMKSKQLEEEKCNKEINEIQVEINNDCLNVNKNESSSKKSPTYKQTKNESAESLDKTQTFEEAITKSTEKLSIEIKSSDIPKTKRQRRKDKKALNTSQKVASGRLEKTCKDDIISIIKIENLFKKFSDSTKDPIEEVVKERSKVATKTQYQFREKPPPEPIDNESSLIILPPSVNIQKCADKNEPNKVIQPEMIKRTKKEQKMVEGTWYNKILDENTLDDVPSDWDENRRPKKKKKVKSNFDKEYDNIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTH7</accession>
    <name>A0A0N5BTH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTH7"/>
    <dbReference type="WBParaSite" id="SPAL_0000916000.1">
        <property type="protein sequence ID" value="SPAL_0000916000.1"/>
        <property type="gene ID" value="SPAL_0000916000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000916000.1"/>
        </source>
    </evidence>
    <sequence length="720" mass="83176" checksum="15802ABAA7A05F96" modified="2015-12-09" version="1">MLQDTKFVFNINGLKVDFYNMNTCDYYKVNNGMELSMKMNELEKYKTEETRYINVEFKEVKIFRLYFEEKKESTSAPCGFATSFSNYDGYYSSFSIAYNEGNNFGDVDYIRLFCTIELCELGLMFFDKYKNVDVLNNIHKVHMVEYAVLLVLQSSNNKLLMNNQPYHEVNIRLGLCPYINWIHKKGWIKYIPVDHIIDNGFFEEENGYGHIVVPYYYKNDDVGAFICGTLKQPSLPDLLVGIKLYNYTGYTGVIGEIDPLNEELKCQSSDNPHYHYHFGYLEKDTNYMSERIMEAINVRDKDSKYKFYAGQKVYIYKWDNIKDGIKNRNSILRLKNPFVFEDVSCIKNLKSDIQANILPTIGSVDSIQKHQKKNLFYRLIKSDEFYRKFSFKCLSKVEGLNKAHMDEFYSRSAVFSIKNEEKPNIIYTSTKNEIIFDRKNIENYGSYRCKESRVTRVFNKNVVTMDKVYYLPDENSELPLEDLKNSNKQYIGCIKQYESLGEIKKIRIEFGENVREPMDIDNFNTGNDKIDMKENLIIYKTPKDVPGVIVKCIYQTPADTTFYTKREIHFHIIGGTEAINDTRLNEMKKNIVTQGGCNTTAWIIGIVVTVVLFCIIMIILINVLVRKTEKEKLGNSSSMSLSSSKSSNRSKSGNNGSSGMGGVRNTTAGRRRNTYKSTVLKTSKNEKDSKSFTSSGGGTRNSTSSNFSKNYAKNFNLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTP9</accession>
    <name>A0A0N5BTP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTP9"/>
    <dbReference type="STRING" id="174720.A0A0N5BTP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000922700.1">
        <property type="protein sequence ID" value="SPAL_0000922700.1"/>
        <property type="gene ID" value="SPAL_0000922700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000922700.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9380" checksum="42A34C92C64B8B8B" modified="2015-12-09" version="1">SSVCSKCNGILEKGDLAVIAPNLGEQNTWHPACFTCKTCDQLLIDLTYCVRENSIYCERHYAELHKPRCSACDEVSFIFKNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU28</accession>
    <name>A0A0N5BU28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU28"/>
    <dbReference type="STRING" id="174720.A0A0N5BU28"/>
    <dbReference type="WBParaSite" id="SPAL_0000935100.1">
        <property type="protein sequence ID" value="SPAL_0000935100.1"/>
        <property type="gene ID" value="SPAL_0000935100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000935100.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55509" checksum="3842BA5EE11651CD" modified="2015-12-09" version="1">MGVRTNHWDSQPVYNPKTQSFSHFLEDLELRMKLDLVEDDNAKLAILKLKLPYEVRDVVNELISDKKVSTYAALALSLKIKLENEMGIMDSQVKLRTFKLDFAKDKFKSSLEDLCRTIKFAFPNMDSISLLTHTCSMVMNYVKGRLWDRLYNHSHRYESVSEMIMDLVSANQLLYDKEPTQGRSDAKFNGKCNWCGIRGHKEIMCKKKKSGEPKVDFNLRKDKFKPVEKENEKLYRICQTGQKNIVLPISINNVKSSGLLDSGAENLSNRSKEYSTIIVNNVKSSGLLDSGAEVTITTKSYMMKLGVNTTQSIKPLKLTVGNGATWTSIGECILNLEIANLIIRLPVYLFEEEEFNKACSEPVLLGIDFLESLSKYTINHINGQFIKFISEDKCENHIVDLKENKSMLRAQVYDTGNDALTDKLKEKFSNVFSENPGKIYVEPVDVLELMKKLPNIVKYSYNLETNDLIKNEVEICFNEKFCIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUW6</accession>
    <name>A0A0N5BUW6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUW6"/>
    <dbReference type="WBParaSite" id="SPAL_0000963400.1">
        <property type="protein sequence ID" value="SPAL_0000963400.1"/>
        <property type="gene ID" value="SPAL_0000963400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000963400.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35872" checksum="648E66B4B16A6CE4" modified="2015-12-09" version="1">MHKPPMDLLSLPGDFKIQIFKKLDWRNLKNLKLVCKDLYFVIEKNIRFLGRPKVYSLSITYDEIKISKVDYRFILTEDTWRGGLLKVVEFSNFTEIKELRLTNGLNGEYISIHYESYSSRDFSRYTFSTGLKNGRCYRDYPFVTIKNSRKFGILYDGNLLKMDSLGRFRLFEENGPCSVGKKIAMDFLTDNPMLEYEKAPTNVCKLIDIQITNHLLELRLLNPENTCVRKGFKLLFNKVYKYGVVRQKYYSKLFDKIKFNSNLVEKNNHDVYLISSSMKCSKCGVKHGNFILYDKDSKEFSITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUW9</accession>
    <name>A0A0N5BUW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUW9"/>
    <dbReference type="WBParaSite" id="SPAL_0000963700.1">
        <property type="protein sequence ID" value="SPAL_0000963700.1"/>
        <property type="gene ID" value="SPAL_0000963700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895030" evidence="1">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000963700.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18660" checksum="DD3308CF10DA347A" modified="2015-12-09" version="1">MIAFKNLLIFLIIFFYQTTEGKQLSEQYHLKFIGNITCDSPKGPLLFVGISKKEPGSTSENHPAQRIHAEYGKQFILQENFNETEKDNLYLDVRHLCLRNEESYSGKHCTIKLTSVKISFNDASYYGKKEGERELVEVKKDFNLSTLDKNFDSKCIESKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVC9</accession>
    <name>A0A0N5BVC9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVC9"/>
    <dbReference type="WBParaSite" id="SPAL_0000979200.1">
        <property type="protein sequence ID" value="SPAL_0000979200.1"/>
        <property type="gene ID" value="SPAL_0000979200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000979200.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15548" checksum="FAE4C78FD8B7D4AC" modified="2015-12-09" version="1">MDIYIFLISILLLLLVLCSYTPFYDIIFGKKNIKTKKKKSNREVLIDNEHLAPPVKIVPKFKAAKPNNIAKLSTSVPWHPEGKPKKQGKYKIYIHKNGALIDNDKHDEKRKNTDKQKPKDNHSKFTEIRVVKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWF3</accession>
    <name>A0A0N5BWF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWF3"/>
    <dbReference type="WBParaSite" id="SPAL_0001014950.1">
        <property type="protein sequence ID" value="SPAL_0001014950.1"/>
        <property type="gene ID" value="SPAL_0001014950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001014950.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8419" checksum="71B6106709218B82" modified="2015-12-09" version="1">MNRLHRHFPKKWKNLNFTSIVFTHKIDILGQLKMSLISIPSNWSLNNASKLCEHLDYVPFIVLSCIPMGYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXK7</accession>
    <name>A0A0N5BXK7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXK7"/>
    <dbReference type="WBParaSite" id="SPAL_0001053233.1">
        <property type="protein sequence ID" value="SPAL_0001053233.1"/>
        <property type="gene ID" value="SPAL_0001053233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001053233.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10160" checksum="22D42709AD4426A4" modified="2015-12-09" version="1">MVTFLDCALICEDTFFALPFPMFDLIDVDLASHILFQIIDMLSKSKALEILLFKRKKKLAKLILKANAYVDQNFITLFRKFEKKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXR0</accession>
    <name>A0A0N5BXR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ornithine decarboxylase antizyme</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ODC1 and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXR0"/>
    <dbReference type="STRING" id="174720.A0A0N5BXR0"/>
    <dbReference type="WBParaSite" id="SPAL_0001058100.1">
        <property type="protein sequence ID" value="SPAL_0001058100.1"/>
        <property type="gene ID" value="SPAL_0001058100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926786" evidence="4">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001058100.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17579" checksum="4D0F4A9173A68639" modified="2015-12-09" version="1">MEMTLVIRLVKLTKTSLTLVAVTISAPDAPSVEDDIHKELVKRAGELVKNVDKDWNGSYLEDENSYAVYMSNHDVLYTVSRTKFIEFFEHCDELLKVRCIYMCFDKQKIFKERFGIPFALRSIGFKMLNPDECPASIDKSSYVVMRYRLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY23</accession>
    <name>A0A0N5BY23_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY23"/>
    <dbReference type="STRING" id="174720.A0A0N5BY23"/>
    <dbReference type="WBParaSite" id="SPAL_0001068400.1">
        <property type="protein sequence ID" value="SPAL_0001068400.1"/>
        <property type="gene ID" value="SPAL_0001068400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001068400.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20747" checksum="7E47FD6EDCB77DBE" modified="2015-12-09" version="1">MESMDTNVEVHDPTECLKLRPKKSILKNKQISIDEESTRKKSNADERAHFDEMNILATLHPEGKDYGHMKIDEPKTPYHGYSDSEEDASSSSGHGKRRVSLVGAIDPEKLREGIYAAQINGSSGSLSAGDVEDLDDDEYLTEEQRAHKKEFEVKRRQHYDEGAALRRAKEILAKDEEEEEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY39</accession>
    <name>A0A0N5BY39_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY39"/>
    <dbReference type="STRING" id="174720.A0A0N5BY39"/>
    <dbReference type="WBParaSite" id="SPAL_0001070000.1">
        <property type="protein sequence ID" value="SPAL_0001070000.1"/>
        <property type="gene ID" value="SPAL_0001070000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000382">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="24"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="614"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="763"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001070000.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="97473" checksum="0BE90037FC6C7801" modified="2015-12-09" version="1">MRKDKKDDESGSGNPYAHLDKAAVLQEGRAFNDTPINARKCTLILSKLLYLLMNGETVGKTEATDIFFAITKLWQSKDTSLRRLVYIAVKDLSSVADDVIIVTSSLTKDMTGKVDMYRAAAIRALCKITDSGMLQAIERYMKQAIVDRTPAVSSAALVSSLHLLKKSPDVVRRWSNEIQEVVASDNHMVQYHALALLYHIRSGDRIAITKMIQKYGKSGMKSPLALCYLIRIAAQLIVAEGATSDSPMHKFIVSCLHHKCEIVIFEAATAIANMESTDSSQLSSAISVLQLMCSSPKPTFRFAAVRTLNKLSTDHPEIVSTCNVDLEQLITDSNRSIATLAITTLLKTGAETSVDRLMKQISSFVSEISDEFKIVVIEAIRSLCVRYPRKHVVMMQFLTPMLRSEGGFAYKKAIVDTIIAIIEENSDAKEIGLAHLCEFIEDCEHTQLATKVLHVLGCECPKLKNPRRYIRYIYNRMILEATQVRAAAVTALAKFGALCEDLRDSIIVLLKRCLLDTDDEVRDRATFYISILEQGDSANLTAYILNVLQVSVIGLEHALQNYISNGDFSSPFDLKSVPLSEKPITVEEHRRPSLAMEDVSAKEEKPKVSRQEMFMEQLSSIPQLSNLGPLFRSSQPIELTESVAEYTVTLIKHTFSEHIVFQFDCKNTLNDQLLENVSVEIEPLDDEGWTIDHRLPLSKLPYNEPGTTYTVLSLPESGAITGSFSAILTFQVADVDPTTGEPESDERYDDSFCLEEIEIGVHDHVQPVVKANFSSNWDELGEENEFEETYSLQNLSSLPEAIKNLQNVLGMGVCEKSDRIPPGKNNHQLLLAGVFRGGLEALAKVRLALDPQDNTVLINIVVRSEDEGVSQVLGAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYD4</accession>
    <name>A0A0N5BYD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYD4"/>
    <dbReference type="WBParaSite" id="SPAL_0001079500.1">
        <property type="protein sequence ID" value="SPAL_0001079500.1"/>
        <property type="gene ID" value="SPAL_0001079500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001079500.1"/>
        </source>
    </evidence>
    <sequence length="51" mass="6012" checksum="F6EE5703FE5A7489" modified="2015-12-09" version="1">MSIRAYSEEDQSWCSKHCYAPTRTTSRPPPPSWGPNDYLVAFILFLWMVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYH1</accession>
    <name>A0A0N5BYH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYH1"/>
    <dbReference type="WBParaSite" id="SPAL_0001082600.1">
        <property type="protein sequence ID" value="SPAL_0001082600.1"/>
        <property type="gene ID" value="SPAL_0001082600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001082600.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14698" checksum="5A84F67B67C168AF" modified="2015-12-09" version="1">MIGISESFAPCGLGVLKRYNITNAVTVFSGCTFNSHYEILGLSVPVAQFPTNVAPLPNTMNIFERILNLISYIVLKKVYSDSINIRNSTFKRFYNEGEIDLHNLFKETAFYIDNCDPLLSFGSPSTPKFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYZ6</accession>
    <name>A0A0N5BYZ6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYZ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BYZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001099200.1">
        <property type="protein sequence ID" value="SPAL_0001099200.1"/>
        <property type="gene ID" value="SPAL_0001099200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="24">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001099200.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17780" checksum="4F649AD18CF74F01" modified="2015-12-09" version="1">MDCKENDSQCLEWINEYIENYKTTDNFNRVARKLIPIRANKTSVLYELKVEKEHVNGKNTIHGGQIASLVDIVTATVVSLTIRDIPMVSVEIATSYLLPALIDEDITIEGIVLKIGRNMAFAEAEFRRKRDGALIAKGKHTLCLLNHLKKNDGKVISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C097</accession>
    <name>A0A0N5C097_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001142700.1">
        <property type="protein sequence ID" value="SPAL_0001142700.1"/>
        <property type="gene ID" value="SPAL_0001142700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001142700.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25519" checksum="9AD8F60BD1192735" modified="2015-12-09" version="1">XLLKIKFFILVKSRSHNTFKPQYDPGIAQYLHLLCYESYFVDGGRCIPTFATLEFAKNFGEKVPNSWHVAVGTDIVPHFSPCKKMKEKNFKFYKRIFDKRKSKPCDPYDHNGYYHHAVEVWYPLGTKSKYFICNGYPKNEDFDCSDGLVYYKKRLVEYRQNHSIYFRELLEEFASMFIYKTNEECYLLEDPKNVRKQLTQSFFLYPKHLIMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1F5</accession>
    <name>A0A0N5C1F5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Saposin A-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1F5"/>
    <dbReference type="STRING" id="174720.A0A0N5C1F5"/>
    <dbReference type="WBParaSite" id="SPAL_0001183000.1">
        <property type="protein sequence ID" value="SPAL_0001183000.1"/>
        <property type="gene ID" value="SPAL_0001183000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF11">
        <property type="entry name" value="PRION-LIKE-(Q_N-RICH)-DOMAIN-BEARING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895234" evidence="7">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001183000.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28812" checksum="8F1DF26FCD6A3312" modified="2015-12-09" version="1">MVVKFTFLLTLLFVFLKLSSGSNYPTHHHTVSYYECTIPPDYWCDSIESARLCGVLQQCETFNRDRKPIKISLMFEALCPYCQRFITNHLGPIYNQFKNYIHLELVPWGNARFMRNGQISCNHGQKECDANKLMGCALDVLHIKQALQFIVCIERSLSSLTVDASLNHCSGFIRSHYRVIKSCYTGPRGIELQRQAAKKTMSVRPNPIVEVPYILVNDYSPNLDGNNLNVNAITQLLQKWTNNKRQYMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2M9</accession>
    <name>A0A0N5C2M9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2M9"/>
    <dbReference type="WBParaSite" id="SPAL_0001223900.1">
        <property type="protein sequence ID" value="SPAL_0001223900.1"/>
        <property type="gene ID" value="SPAL_0001223900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895248" evidence="1">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001223900.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22079" checksum="8D651341E23D2919" modified="2015-12-09" version="1">MKSITEIFVFILLINLLLIKFNKANEHSIEEYTQKNCEGLIKKRDLIVSIINKLGAKDKNPLNATETLTALQIYFAVFNQVEDEIANCVKNEFISTYDAAAKNFDFTTFFNDINVLCKHILEMKDFIDSKLDEVKQIAGENLFENPHLGRYMIILRTAYYYDSKLRECVQKTLRFSYHKKIPETVNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2W7</accession>
    <name>A0A0N5C2W7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nop domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2W7"/>
    <dbReference type="WBParaSite" id="SPAL_0001232400.1">
        <property type="protein sequence ID" value="SPAL_0001232400.1"/>
        <property type="gene ID" value="SPAL_0001232400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001232400.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40398" checksum="005D59B8CDFB700C" modified="2015-12-09" version="1">MSIHEHEDDFLLIEDDGEQVQPQGDNEPAVVNPQVPEEDVAFLDVNALEGEVDLDAILGRYSRNLRSMGATVEAVLLLMEMGEEVSGLERKLLWAKESHITVLNSFENLTSIHDAGLAFIRRRAALLAAVGENPTVRQKDAIDTKAKSCVSKRLDYQVARTTEDIMSVYQSIAKIEATCLRIKHVFGKLSGRLSDKLGCLWIDGSVIPSPLSPASLIGLSSLQMLIVSGCDTLKLLLSSLDKNIPLKVIVSLCKPHKCLCKKHIRATSQLDLPFKIVIVPDRRYNGQAITQNATVRKNLFFHRMGTIYYKNSHWIKTFAECEYPEDIAEIQGERKEDALHGSFGIYFLNSIIFCLKYNFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3A0</accession>
    <name>A0A0N5C3A0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3A0"/>
    <dbReference type="STRING" id="174720.A0A0N5C3A0"/>
    <dbReference type="WBParaSite" id="SPAL_0001245400.1">
        <property type="protein sequence ID" value="SPAL_0001245400.1"/>
        <property type="gene ID" value="SPAL_0001245400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895374" evidence="1">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001245400.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45008" checksum="11ECE58C0362D342" modified="2015-12-09" version="1">MLIILYSLFLLFISTINGEVVPATKDNFDQLIKKHSVLIVNFYAEWCRYSQLLKPIFDDASEKIAEDVKKSVGFVSVNCEEQVDLAQKYNINKYPTLKIIKFGEVAKREYRGQRTAEAIAEFVTKVLKTAITHLRSEDDLEHKLDKTKNAVIAYATTPSKQFETAIKTASSFMDDCNVYIAFGDWVKNVTDKDPKFVFFEHKTGNKINYEGDHNDIESIKKWVTDVCVPLVREITFENAEELTEEGLPFLILFRKQGDVESEKHFIDAVKRELEDQKPYINALLADGKLFAHPLHHLGKSEHDLPLIVIDSFRHMYVFKEFSDIHKSEGKLRQFVLDLHSGKLHREFHYGPETEAPKAYEDPIPTSPPESVFNKLKPSEQRYTVLNKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4J2</accession>
    <name>A0A0N5C4J2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1758 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4J2"/>
    <dbReference type="WBParaSite" id="SPAL_0001287300.1">
        <property type="protein sequence ID" value="SPAL_0001287300.1"/>
        <property type="gene ID" value="SPAL_0001287300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001287300.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49059" checksum="CC23AE4BA2B6BEE9" modified="2015-12-09" version="1">MSTFNQFDANIPLPIPNFPGKLVIKNILADGIYSKRVNKPLSIMEPSINDLLTWYWQIELKSKRCPSEKKRRELILESIPDELLEDYSADDLDEKDSSALLHVASQFVKRKWLLEPLNKRFEMIGQNITISTRTNPYTYALKKIKNSAELLGFDDDVDNMVIQRFINLLPRGVVGKENLIQPRDMILTNWLTYAEKLDENHSRFKQVASAATTTTKSHIVKMKEIMLPKTEAKSDGKAEVKTEVKSEVKSDTKQNRFSMGNPNGATKKFFIHEKESDDVSATLIIDSGSSHSYLCSNTFDKLSDDTKKMLEKNDVHEVEVGDNRIKTKTFGSILLNISIPFVDAFNIPIKFFLIKNCNHNFLSLDESAKLHALSKLETERLEAIDVEKKSNISDKVPTKIKNKLDKLVYLTNDDYSRPPTSVHTIRVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5U9</accession>
    <name>A0A0N5C5U9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5U9"/>
    <dbReference type="WBParaSite" id="SPAL_0001332500.1">
        <property type="protein sequence ID" value="SPAL_0001332500.1"/>
        <property type="gene ID" value="SPAL_0001332500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001332500.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32474" checksum="AD46164F529A96AF" modified="2015-12-09" version="1">MDDLGKTRNSAGHTNKEIYNIDPPLSEGRGTQNQQEVHNNVQNLTIDKLLQRMELMMKVHIETMTSIQNSIKIQADNMLSLREKLDSKENLKKEKDESPSISQLPVNEDLEENATKETSQTIISYVNSVNEVKNKESKEESESDEIEISSKRNRGTPKGLIKRKPGKPKESTTRKKDTTDKKLFQKYADLFGQIFKICNSNNLLLNIHKSKFFHAELKYLAYTLNRNSYTQSLQCVAKLIRKATSTMTTFLDSLIECKVNWIEPLISTIYNNKFKVGDYFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5W5</accession>
    <name>A0A0N5C5W5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase_M13_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5W5"/>
    <dbReference type="WBParaSite" id="SPAL_0001334100.1">
        <property type="protein sequence ID" value="SPAL_0001334100.1"/>
        <property type="gene ID" value="SPAL_0001334100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF233">
        <property type="entry name" value="PEPTIDASE M13 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001334100.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="36689" checksum="8857D9F79E3C0619" modified="2015-12-09" version="1">MNVFVLIFYYFGLNFVSKGFIMNKIVNNPTRYDPELTSKSLREYVDFTVDPCDNFYKFACGNWIKDKEEKSKNKTSFFYTETSTNFLNFIDEAFDGRYNNESTAIKNIYNLRKKCIQLSEEKKKNCESKIQVFGSYAFSVLFIKKSRIEREKHGDYIIFENMIKRLKEEFRILIDDKKDIFDKESRDNLLHKLDEIELINLYSLDISSILLMENCYKNIGISENDSIEEVIKNLTLLSKLNHTLGSCGYYIFRPAEYSDYKVFFAAFYHPIMNIFFTTSNDLVEPWFSSYKKYIHYRMIKCSKKNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7P6</accession>
    <name>A0A0N5C7P6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anillin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7P6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7P6"/>
    <dbReference type="WBParaSite" id="SPAL_0001395700.1">
        <property type="protein sequence ID" value="SPAL_0001395700.1"/>
        <property type="gene ID" value="SPAL_0001395700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001395700.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53817" checksum="49C82CE7E9E482FD" modified="2015-12-09" version="1">MVAVPYAESKARIILRNINIPLVDSYCKNGKNYKSDKRMFRLRLSIKCGDKEILTPIVENLSAKMMNVEFPDEYIFDNVPSNFSLTISVLSLRPGFTIGKGNNILDKLTSTLTKSMGGNTYDKTSTLTSKYGTITPHFVYDYPEDQNDLLQNVAKVKLSLKDVNHISETVFRLKRNDNFSLESDLFPPLFGTISLSMILQPQSLLTPLKQGFATITLCLQQRTLRNVYCILKSGNLTIFNTAPLHSKDGTIEIPVNSDTVIHIDRRTDSIVLSAVVSKNEMIKEVIIDVNRNEEVLEWCKALSTQIVDTKIYGNASSKDYYTIITKGYRSLKKSNALQSPFSIYETLLSTHNTLQKKEPKKLERYDNLVDSGYISSTVSGLSNSTPHIINDNYHSTSSKSPKKLRRITVMDYFEKHSPGNSNFYGTVVTEKDRTLEKKNKNVTFDKNKYALPRCGELIDRANKLNSKKYLETTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C851</accession>
    <name>A0A0N5C851_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C851"/>
    <dbReference type="WBParaSite" id="SPAL_0001410700.2">
        <property type="protein sequence ID" value="SPAL_0001410700.2"/>
        <property type="gene ID" value="SPAL_0001410700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="2337"/>
            <end position="2372"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="2412"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2519"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2587"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="249"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="871"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2600"/>
            <end position="2614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001410700.2"/>
        </source>
    </evidence>
    <sequence length="2656" mass="306896" checksum="F32A444FDFD633D4" modified="2015-12-09" version="1">MTDLVYDNKNTENNISDENSFDDQLANSRVKIIREYLSKYEKELSQDLADTDKLINEGTEMEIPSDELEILKNNKEKIKEAVSKLQNEEKLMSTKIADAKENEAILNEWKTKKDLLLRFINENNKQLSNIKDNCKSTEIIQSLLPQLNDIEIEKATKKPLYEDIKKVFSLFKRTVPIPNLSLLKEEQHQLDEMWLDLDENLKKTKGFCNDSLNFFNDSETFKKWMADKDQLLSTIGRLSADSKYIEHQIALLERLNDEFENNKINHKQLNDLSSSLVQKSSNDQYNYIITAKINDINEQWNLLQTKLNQAKNNLIDCNRVCQEFKNNQINIKNQLLDTEKQIDRTTFSLTENPTDLEEVFYQIDDICTQGANIVEPLIIDSENLLKQLFEMSGDKDIWKVLNNDLDSSKERVDKLIEKVQNIKNLSNVSKNATLLNERIVEMLENPIIKQPISNDIISLKHQQKELSNFRNNEVKSIGDETTKILESCKGILKVADKTLPCYNIEKLIDNIQKSWQELNNQLEIRDREISTKIQSIGNYDDAFRSLCNWLEETEELVMNQYKPSADAKVLRTELQNHNFQMKMIEDKQPNIDGFLKLMDKFVESTVDENEKDALKEKADMIDSRYRALVDNCNDRRVALQDALMYSIDWTSKTTELKQWLDDVNKDLEVIGKIATEPEKFEEQLEAQKFLKEEIDSKRPDFEFLVKIFNPFADLVSEDDGIELENTLNSLSERYDDVGIRCMNCGKSLEEMKENINSFLADTNDLSSWLDQIERELKKFDEIPISTDELIAQSEKLGELVGTITERENLVSRVVEDSRELCMHTSGPEAMQLQYRIDALHQRYSKIASITDKKIDTMSTAIPLSEDYCVMYDDLARCLEKIEKELEHAEYDTISKQQELLQDLSKELFDNRNQLEVLNTKAIQLQGLSSEGKAEELKEQTKELQERFMELHDVINRKCERLNIASSRHREIFDELDNLLDWFTDAHQHILDSKPPTVDIDNLKAQLKDQKVFNDDIISQKIFLREILGEAAKYVKGVSDPTSISDNDDLNDKINKIKFLVDETSKLSEKRLEDLEEAYELCIVMEENFNDLNDWLDNMEEELSITDVNILSLKPEQLLKLKQQNSNIFAAIQTQKPMFEKFDKNVNSFIKLTSPEDAANLQLFADEVFTRYEDIANTVLKREQELNNNLEDSTLLEDRLNFMINNFENIAERIKNFDGIKAKPEGIKKQLLENEMIIKQIKSKEIPLLNLQEDATELLKKTPPNDLVSNEIAKNVDYLNSLWNDIIIASNKRDNLLQTALKTSEDFWNSYSTCHEAINNLKNNINQIPLDMSSDPNEIENNRIKLSTLLNDYTLFTPSMENMKFFGQNLSSYIDSDEKELVEHAISSIEMDSVDIGNLLNQLTNDFGQAIDKSTNYHTLFKKVMEFIINMEDIVYNLPPITATSIEDIQNELTNISNLRGQIDSNILLKEQLNSSAQDLLLTAQPNQIVAIRSPLNELNNRWNKIFTTISDRFHKLEKSLLETGQFSQAYDQIMLWIVKTTGNVDQIVVPTGDLRMIEINLSKINLIKNDVMAHEQSVLDLKRAGKSLISLDPSSENVIKVKLEELNKRWTDLNDTIDALISSLESAKNDASTLDQELDGWLMWLDDIESDLGLNKPIGGLPETARTQLDDFLVLNAQVEQKKDELNKLLDSKTNEGSGETWSQQQHNRIRKKWDNLKEKMKEKHDKLNKALEDAEKFQKDVDEISDFINYGENYVSMLPQISAIPETIQDQLQNHNEFNSKVENNKKKLGELSTKGSKLQFNCEKKDAIPIKNKLTTMRHQFDKLNNKSNERMKNLKNALAYSTDYVEGHKDVTKWIKDNSTRMKEDPIISTTGDRIRDQLEDENNFKNIVAEKNPLVNNLLKKGKSLEESAPKSEKGVISKMNNSLTRDWDTLNDALNHRFQLLHDALLQNGKFEEALNDVSGWLHVQLPQLEKDLEMERLYGDVDNVNYLIKEHNKLKEDINEHSTAFIKVQKRYQEIKNKEPDALADDIKNEIDNMVHDWGKLNTLVDEKDNILKDALTKAQDLDGKVNDLLTWIGKTDNNIKKNSTLKPSQHEEDFLREQIDNLEYTLEEIDSKEPDFEDLVNVGEEILQKVHPSAEIPVKDTINMITRRWDALKNIIKDKRDIMKESLKSFRDNEKLLDELTGFVEGKQHELDLVMDISNVNSLEELANRFSNHENFKEQLTVKQEPIENAIKGYKKALIAANIIHQNEPINQLKDSKTDKKVKLGLLPTTHSQKYFKGDKLNNSWKNLWMNSMTYEQALQERKDYLEELKRLENFDFDEWKERYNEWNDHAKGRVTDLFRRIDKNGTGKVPRDIFIEAILASKFNTTPLEMEKVADIFDKGDGFIDAREFIRVLRIDPKKSKPKTDEERIDEEITRQAKRCTCAQRFPIKHLGASKGTVSYGFGHNTSMKRMVRILQSTVMVRVGGGWEEIDSFLVKHDPCRTKGRTNVELFYSGVQPGTNSDQIREFVSKSPKTSTVTPARKNSGIENFKSPKQVLGYPTQGPVTKIREKTEKSIPMFATPKRPSISLERKAHVNLLQHCTSDSRIPRPTASLNSSSRSTSRSDLNFLTDSRPPSRCSDISDFSDRPPSRIPSLRKKKKSTSSHGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8P9</accession>
    <name>A0A0N5C8P9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ku domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8P9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8P9"/>
    <dbReference type="WBParaSite" id="SPAL_0001428900.1">
        <property type="protein sequence ID" value="SPAL_0001428900.1"/>
        <property type="gene ID" value="SPAL_0001428900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="2">
        <location>
            <begin position="222"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001428900.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="55101" checksum="5DE7FCBE547BABB3" modified="2015-12-09" version="1">MLYLEGSVVIFFDGSFKNEISFNKGRKILEKIIINKMMIPNKESVKLFCNIPIFEYPLTLNADNSCRDFFKIDKITGKFIYSEDIGYDDIIDIVVTSFSEEEKSSKLRKKVNTNVLIISDLSSLSGSKNKIHKFEKCLTKFSLNVYIFGAELNNQSCNTSQLGTYLLQIIPQERCFSLDRSDDFVKYFMAPVVRAINNKINFEIDHGCFIPLHGYVNHVRISDKFSIKKIIEQESSKPLKRGYLYKNDEGGKIESDYVIDAHRYGNQLIPFNFFDQPFHSIELDEKSLKLLQFAPRNDIDICYLEPPVYHYFIDKSDNDLAKRGEELIKGMIERDVVAIGSRTLSKNSKPKLVVMFPAISKSTSEPILITFISVFKESLKFSKFPLGEKTIESLTTREVALMDSYVDAMILESHDNRYKPENTADPFYQNKLSIILEKATKEDIYDKSYIEGILNLDSEKVEKCRNIEKKFSDHYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9H2</accession>
    <name>A0A0N5C9H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9H2"/>
    <dbReference type="WBParaSite" id="SPAL_0001455600.1">
        <property type="protein sequence ID" value="SPAL_0001455600.1"/>
        <property type="gene ID" value="SPAL_0001455600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001455600.1"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118444" checksum="00AAD1613A58AC92" modified="2015-12-09" version="1">MEKLRGRPVGSKNRKTLFRETRSKAASNRKSFPDIEDELPPFSLPDTSGLKRVSREASEKSENNEIKQKSTEKNNIENNDLKSNSVSVKKSLSNIEDELPPCSLPDTSGLRRISRIADEKSQNGELQEELNEKTIGDARTPAPKRLFSNIFRNSTIKCQESRKRKESSIGIRVSPRKIRKVCNSPKVQEVKNKTSQKTVPEKSIDLLNLTTESINDKKKNKANSKVGSAFERSSFEQNTEISNDNLDSEIVDEIEESDKTIETYKKKYESCRVMLIKERKKNESKRESQVKELELLKKQSFESSIALTKAKIENDKLKKECEKLKIALQNSNQVINKSQDIISQLRKKISEKDMQVAAVNKQIENYEQNQPSLRKGGKTFSRETKLYVFSMLERCISYENIDYTLKRSIKCFLNRELDDCISRRTFYKWTKEFKICSLCISGYLLEEFIKKNGKGVLFHDEATLKNEKLQIFVLCGNADGIFYEILLGAVEAKDKSTESTIEMFEKLIGSLAKVTKSFKFKFLQDTYNSIYGYLSNNIKTEKISYDSLSEIANRGKDPNEIRKYVTYSCVSYIGSDISKTIEKSLHNLSSGQETLNILKQLSKDLCIKSYAYRPIITAFRISTEDEERETSTSESNFTFIIDDDFQICKIIYQDINYTHNEILNYSKINNGMHELCKKVAPILQSKEIINVIAFTLYLHELFIFPIVRAGESSDIRQFLRYMKHLTEVIEIDQYSKLLDVEKIKAEFGDNYNIFKYEILNALSKMIKSVFEDNSVRSEKEKMIKVLKETVEDVKNKFINVYEKIVNEENYSACSIKTQTTIIAEHIFQKVRHNSSKSPYKDMVMKSAQVAASYNNMTEMLESISNNELDDIFDRVKVLTCVVENDFKDLSESVSKDKMDTCSKLTESCERRNTKLKVSKFLNEQLGAKETIKAMEEINEILAKLLSQNQKEKFLRHQLRLWKKDKNSIIEVPKMSNETDKYQRVYKQLQYCVNKFNDSIMSSITYQNYSHNDDEESSDESSGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9L5</accession>
    <name>A0A0N5C9L5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9L5"/>
    <dbReference type="WBParaSite" id="SPAL_0001459600.1">
        <property type="protein sequence ID" value="SPAL_0001459600.1"/>
        <property type="gene ID" value="SPAL_0001459600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="835"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001459600.1"/>
        </source>
    </evidence>
    <sequence length="900" mass="104103" checksum="203125D782B7A38E" modified="2015-12-09" version="1">MLPKSTDTIKNCQNVVKNKRGRPKGIKNKIIGKTICKKPIQKKSTSCGDLLSYNCSSIRSDEILNDENERALVPSVQKIDQVQVQKDTIFRGYDITESPSNTLQCKHNYNFVLNGFYHILANLNESLNNISNGNNENSPFYKNIIDRFLNPKNSTDNRSNKENSLNSSDRTPSNGSSSICSSPPRIISTYQYRKNETKYLLMSNCRSYESYEEFLENYDNQNMRINKVTKDKDGNVISAMLICRKSSDCRYKILLKKHVSLAENQSTDLQFPTISNIKEVYCEFVSDIEPHLHDGISEDTYFHKAKKCCLSSTQLNFVTSLRKETNLPLSKIVKLGRENEDVQLPKNYSVRQIRNKIKYVKHKQEVNDPSCSLLTFCDLMIFCKKFIPFHLINEINEKKCNKDGINFIPVGEETNPNEINPAYIYDCSTQNNYENIINRYDDFIEIENERCDMLESGNVSKSSKILIDSKKMKDFLVSESNDHKPYCYSFMFHETVSRSCFSIFFSTPTLMKILQSKTIFSIDATFKISDTDMKTIQIVVRHGDSYIPAGIIIATNESFDALDHIFYALHNVYKVSQNLRIMVADFANCYTLLSNGGGSTDISNNRYNKFLRGGCIFHFKTSVFKNKTFKSLSPFYQSQAKLFVNCFCNAVNRDCAISLIKNFKNFINGVTNKDEQNHLEEFHSYILKEFFLKNNENMIIYSKYLYGMSTNNGTEGLNSFLKRFNDYKRLPLNDSLYALLGYVSINSEKIIDIQRSTSLITDFKKKQIKKAEEYAYKKQYVKKVFGSQVIYLFPKNVCDLNVIDENISKYTNTNSTFTLDEYDVFIKSVNISTMLTIERIDKTKNHIQYCDCSIYRNHKYCSHSFFVSENEKGNYNNLIIPVNPSQKKSRKRNNKGWCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9M4</accession>
    <name>A0A0N5C9M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9M4"/>
    <dbReference type="WBParaSite" id="SPAL_0001460350.1">
        <property type="protein sequence ID" value="SPAL_0001460350.1"/>
        <property type="gene ID" value="SPAL_0001460350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001460350.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10744" checksum="F8410C0D9F059151" modified="2015-12-09" version="1">MNKITAWIRELEKLKETLSYRSKMKYVLSAVRHLKHHPELTEKYLKCKDTHEAYLKFQKTVLSALTKKMESQLPTKTKTDVPKQQKKIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9X9</accession>
    <name>A0A0N5C9X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9X9"/>
    <dbReference type="STRING" id="174720.A0A0N5C9X9"/>
    <dbReference type="WBParaSite" id="SPAL_0001470600.1">
        <property type="protein sequence ID" value="SPAL_0001470600.1"/>
        <property type="gene ID" value="SPAL_0001470600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900075">
        <property type="term" value="P:positive regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16478">
        <property type="entry name" value="RING-H2_Rapsyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052480">
        <property type="entry name" value="RAPsyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019568">
        <property type="entry name" value="Rapsyn_myristoylation/link_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574:SF1">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10579">
        <property type="entry name" value="Rapsyn_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001470600.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="67021" checksum="32E8FE1E54FDAE38" modified="2015-12-09" version="1">MGQRFARHLMYSGVKRYHQRSHLSAINKWQTALRRLRDAEDRFITLGYLAQAFCDLCDYGQMLHYALLQMELANSRQDEFMKSEAYLNLSKAYEKLADFPKSINYGKASLQHPSIDPRTPGYAYLSIATAYINSSQFQLSLSSFEQAMNIANQTGDKLLELQVCIGLGSLFTILKDLSKALLFLQNSLQILQSITVDHLHAKYKCVILYHLSIVMKLKGKLINAREACEEGLRLASETNNRAIYGRCLCSIADIFRELGESETMETITKSWARYESAYRLMNKINDKMGEVIVLSSIAKSASESRSHYTGQCECQAIQLNKKCLEIAKSIGCKHAMMKCQLRLQELYQQLSDEDSEENCKHSITTLIQEMELFCNFCGQRYGINNESLRALRCSHIFHEKCLHIYLSQQSEQTCPKCQCRAILNDNISIQTTSITSTSPIDYNKNSLNFSRYIKQKRSSSGLDETSIKMRIKNIKLPLQGHQEDILNELPPVPDELLFNNNCKQHTPTTVVQIQDKLQSPENDSYNKLNKPIVFPFPRRMTQSLNIREPSKSFENVNNLPKTNPNFNVIIENKPKIIHKQPPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Z2</accession>
    <name>A0A0N5C9Z2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0001471800.1">
        <property type="protein sequence ID" value="SPAL_0001471800.1"/>
        <property type="gene ID" value="SPAL_0001471800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001471800.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18547" checksum="61874568CFB91D87" modified="2015-12-09" version="1">MSDDFIIPKKGKTFKPTSQVQKNAIECYKKLVDVTEVNENIIRENIEFKKVSNYYVKGKKDKKVVCDKKKKVTNNSNDKIIKVLDDEFDKELEILTQIKKERVQICLQQKKNERIESEIVLESETLTDFSKLLYTPKDVHDLFTEMFYDIHRGISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBC2</accession>
    <name>A0A0N5CBC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBC2"/>
    <dbReference type="WBParaSite" id="SPAL_0001518500.1">
        <property type="protein sequence ID" value="SPAL_0001518500.1"/>
        <property type="gene ID" value="SPAL_0001518500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001518500.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37151" checksum="F00414A3728BF8B0" modified="2015-12-09" version="1">MTNIYYSIFLLTIDCICIPFCLMMTIFIGWSIKKTNVEFYTPFYVQLFLNSCCELIFFAFEYFLIRIPLFGFADDWYNSQKHLPGAIHGFAWYVYIVICIGQCNLMLNRFIVLKNPASNSSMSTFKSSLCLITFQFIFPIFMIFMPINCNLRSYYVNNNKTLVVEVEDQKISNFFLTVGSIVGIIICLFCITFGSWNIFLLKKIQNSKKYYEKRLKKEKPLLLSVCLQTVNFIVLTTAEILQYFAGKFNLDRLYAFTIYMYPLSEDMLCLLHPIILYITCHSLRKKFLNFWFRGLYKKIRGKKIAPLSDIKPMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC91</accession>
    <name>A0A0N5CC91_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC91"/>
    <dbReference type="STRING" id="174720.A0A0N5CC91"/>
    <dbReference type="WBParaSite" id="SPAL_0001550000.1">
        <property type="protein sequence ID" value="SPAL_0001550000.1"/>
        <property type="gene ID" value="SPAL_0001550000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="141"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001550000.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51466" checksum="EB3B6C851B912034" modified="2015-12-09" version="1">MRDSVAVVQEVVDKKSNCETLSELLQLPYYHGFLPREDMRRLLLKPGDFLVRLSQPAEGKPRTYVLSVAKESGKLKFPKLKHYLLTKNQKGMYIVEKKQFETIKELVENYWKGKQDGSNKNEIFLLNPVERKSWELNHSCIKTTKRLGEGAFAVCKLGKFTHPKKKTITDCAIKILKLEKLNKKQIKEFSKECRLMRKLDHPNIVKFYGLAAQQEPLMLVMELVRNGSLDSYLMKNVVEVKVKIKMCCGAGRGISYLHSLNIMHRDIASRNCLVDSEENIKISDFGMSVVGKEYDLDPTDKVPVKFLAPETLRNKKYYHKTDVYTFGILVWEIFSNGKEPYSGFTALEAIKKIVTESYQMPFPQETPDFIKECIYSKVWLQNPEDRCSMEEVIKILDKDYNNNNKEINVDFTEVEDIDSKSKLDLSIYQLPDVDDNKVNQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDF1</accession>
    <name>A0A0N5CDF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDF1"/>
    <dbReference type="WBParaSite" id="SPAL_0001589700.1">
        <property type="protein sequence ID" value="SPAL_0001589700.1"/>
        <property type="gene ID" value="SPAL_0001589700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001589700.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11027" checksum="C4715FE84C0E3BB6" modified="2015-12-09" version="1">MAFMYPQNYPECPLLLTEPAWYSDDYPEKEELHQLFEQYKKDRNTSLNIVPGTPNADAGNDTDDPTPSSSGPFPTAALRTDGNDEDEDNDGPPASDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE49</accession>
    <name>A0A0N5CE49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TMEM189_B_dmain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE49"/>
    <dbReference type="STRING" id="174720.A0A0N5CE49"/>
    <dbReference type="WBParaSite" id="SPAL_0001613900.1">
        <property type="protein sequence ID" value="SPAL_0001613900.1"/>
        <property type="gene ID" value="SPAL_0001613900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053335">
        <property type="entry name" value="Fatty_acid_desaturase_CarF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48230:SF1">
        <property type="entry name" value="LIPID DESATURASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="7">
        <location>
            <begin position="97"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001613900.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32661" checksum="FECB55D78D108B30" modified="2015-12-09" version="1">MTGFVQTSLREIDNDFYENEIIKRNLANNTNKNTTQQSNKHSGAKELASLYSKEKRLQEILSLILGLSLIVLNGFFLIRSINQISFSSLIVNAILGIFVADMASGLVHWAADTWGTVDSAFGKAFIRSFREHHVDPTAITRHDFIECNGDNFLIIIPVMAFVTYQHLFYDDDYLQECLSGQWFYFLLCIYVSMTNQIHKWSHTWKDINPIVKKLQSWHIILPRQHHKIHHIAPHACNYCITTGWLNYPLDKIQFWRGAEWIVTKLTGLQPRDDDLMWAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFL2</accession>
    <name>A0A0N5CFL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Germane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFL2"/>
    <dbReference type="WBParaSite" id="SPAL_0001664800.1">
        <property type="protein sequence ID" value="SPAL_0001664800.1"/>
        <property type="gene ID" value="SPAL_0001664800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035126">
        <property type="entry name" value="SCVP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17619">
        <property type="entry name" value="SCVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895798" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001664800.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15703" checksum="09AC82D89039477F" modified="2015-12-09" version="1">MQFFKFFLFAALIITINACAPTNTQSAATTTAPKRKRRSVDEDNAVVIKTTFDSINRTKAHQIEGLLLDKFASSLPAASSNIDRSTKLTNIEDGKLTTTITFHGSSNLCSKIIRLIKDTFNGNVFVKNTTIKCGNNETISIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFM0</accession>
    <name>A0A0N5CFM0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na_Ca_ex domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFM0"/>
    <dbReference type="WBParaSite" id="SPAL_0001665600.1">
        <property type="protein sequence ID" value="SPAL_0001665600.1"/>
        <property type="gene ID" value="SPAL_0001665600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001665600.1"/>
        </source>
    </evidence>
    <sequence length="43" mass="4698" checksum="3FA411EAEEA50332" modified="2015-12-09" version="1">MWRQSEESSEGVLGVFMAFTGSLVLPSLLTNILLALFAVIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFS1</accession>
    <name>A0A0N5CFS1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFS1"/>
    <dbReference type="WBParaSite" id="SPAL_0001670500.1">
        <property type="protein sequence ID" value="SPAL_0001670500.1"/>
        <property type="gene ID" value="SPAL_0001670500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001670500.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11254" checksum="700F9294BE55F496" modified="2015-12-09" version="1">MGDNTRTNKKAYEILSEKANYEKTESEIRRFETYLCVAIIEINLSKSSGKPLHNLSSDEETLNSVKQVSKELCLRNCVYHLLAVALNTFTQNRVTKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHI1</accession>
    <name>A0A0N5CHI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KTSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHI1"/>
    <dbReference type="WBParaSite" id="SPAL_0001729725.1">
        <property type="protein sequence ID" value="SPAL_0001729725.1"/>
        <property type="gene ID" value="SPAL_0001729725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001729725.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="8007" checksum="CBFB79576A2614C5" modified="2015-12-09" version="1">MADPWTTPSARDRFYYVVFSPYNDARFLSDFNGLDRAIYRRRENYVGQPYFIDSRDIEMSKKRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHK6</accession>
    <name>A0A0N5CHK6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHK6"/>
    <dbReference type="STRING" id="174720.A0A0N5CHK6"/>
    <dbReference type="WBParaSite" id="SPAL_0001732100.1">
        <property type="protein sequence ID" value="SPAL_0001732100.1"/>
        <property type="gene ID" value="SPAL_0001732100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001732100.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24791" checksum="C20BC02B471A6FF2" modified="2015-12-09" version="1">MFDPEYGKKIKCRVWRELKQGCPASPMLFNAILEFLYRNALLDDSLNPLPNFGVAVSGLQVVGISYADDTTLIADSGDSFKEMLSTFTYHFKRVELNINLDKSNYMAFKIEMENSFEIPPCTSFNYLGRELSFLERRPFIRQIKVKGYKALSVIRPTLRVVLLKARRFPFQSTIRSCYTYACQTWTLTKNVLYDIACLDRKFIFSCKLNKCGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHX3</accession>
    <name>A0A0N5CHX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHX3"/>
    <dbReference type="WBParaSite" id="SPAL_0001743500.1">
        <property type="protein sequence ID" value="SPAL_0001743500.1"/>
        <property type="gene ID" value="SPAL_0001743500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001743500.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39512" checksum="C218177CC049CBF3" modified="2015-12-09" version="1">MIDPNEGCSKCKQFQQNALDAYAIIKRMSTQKNRSAPELAEVVNLKKLNDEQAQYIINQRKVIERISNEKDELDSSNKHLKIKNEEMNSQYNDLILQLGDFRRKLEDITKELSETKKNNAEISKRNESFTKSMEQFVLCKKMLLTTFSIIQQIKSGQISGKLDKKSAAVVNNFDLDAAYNKVGLHNRSKKKNNKKVSVPVEKEDSDDDLEKLLLAEMDISSSEDEEEKVEPSVSQSNTVSAPTELVNRVENEQVPKKIVKPAPPRNIRKSTRVKGEPKKTEEPLQPVVEKVANINKRASNTITGRKTKSVKEQISNMDIEKIKEKYKSDMEQMKKNVEAIKKTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIA5</accession>
    <name>A0A0N5CIA5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase_II domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIA5"/>
    <dbReference type="STRING" id="174720.A0A0N5CIA5"/>
    <dbReference type="WBParaSite" id="SPAL_0001756100.1">
        <property type="protein sequence ID" value="SPAL_0001756100.1"/>
        <property type="gene ID" value="SPAL_0001756100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001756100.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13485" checksum="4D189095FC2DF751" modified="2015-12-09" version="1">MKVLGLQNLSSKIFKKIADIDKEQSNYDEEEIDVRNNLACLYRIIDYMGLSQSIFNHLTARISKLKDEILINPFGLLYHEITSSSLIKVDIKGNILEKGSTNYGVNNAGYILHSAIHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIS0</accession>
    <name>A0A0N5CIS0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIS0"/>
    <dbReference type="WBParaSite" id="SPAL_0001772500.1">
        <property type="protein sequence ID" value="SPAL_0001772500.1"/>
        <property type="gene ID" value="SPAL_0001772500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001772500.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37469" checksum="650A1F3FDC5EC217" modified="2015-12-09" version="1">MEIPIIDGIFLIFQIFGYILYIMLAICFVFKIINDSKRECDITSFLYHFIANSIFDIIQPLAIIVFQKSIHWKISIQFFLTSTWIKRVYSPICFISIVGLILGHLISVVNRYYALYHSITFKTFWTKKTCLRIIFLQYFIPIFIFSYSFFYEAKLVYVPSFDIYVFSLTGKEINIANNVIFVGIPVISAIITATLNIIIFRKYNQVIAKGSGKERSKRFLMLSYMVVTTICLIIFATEQLLRLYFSSINKNDGLVLISFTLYWIIPSLTILQPIMTLIMSKNLRDYFLSFYFKRFLGRNKQISSTFNLKTTAAVTKRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Y5</accession>
    <name>A0A0N5B1Y5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Y5"/>
    <dbReference type="WBParaSite" id="SPAL_0000008700.1">
        <property type="protein sequence ID" value="SPAL_0000008700.1"/>
        <property type="gene ID" value="SPAL_0000008700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000008700.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13688" checksum="8FCCE7CE85285E61" modified="2015-12-09" version="1">MVGEAIAPGCVEDVMLKVRSCHAEISGMNVERLIRDVKEFWDIDLIDFAYKHNFGPYPDFAAVVNFIRNIEGATLVPMRNRSGNFFVHFKRPDCLAQMVSMIHASKDKKRNRPSFRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B209</accession>
    <name>A0A0N5B209_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B209"/>
    <dbReference type="STRING" id="174720.A0A0N5B209"/>
    <dbReference type="WBParaSite" id="SPAL_0000011200.1">
        <property type="protein sequence ID" value="SPAL_0000011200.1"/>
        <property type="gene ID" value="SPAL_0000011200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000011200.1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4550" checksum="148BB209C597DC20" modified="2015-12-09" version="1">KTAFEAFIESRTPDFYANGINKLVSRWQQCVDSNSSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B256</accession>
    <name>A0A0N5B256_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B256"/>
    <dbReference type="WBParaSite" id="SPAL_0000015900.1">
        <property type="protein sequence ID" value="SPAL_0000015900.1"/>
        <property type="gene ID" value="SPAL_0000015900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF193">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="266"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000015900.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="99221" checksum="ED1EFF06A017BEA1" modified="2015-12-09" version="1">MKWWSLEPLLKLFFYKYGKFVNRYRWLCFIGPLIITPILSLGFLKAGDLLLDDPAYTFTPYNARWKNELKAFTDIWPMDENKFIAGKSFEMKRFVNILVRAKDGGDILRPIILDEIELLNQFIMNNVSVTTTDQQFNLTYQDLCLNYEWKCGGNEHIMMFKEMSKLGRVIDLKYPKGGNDDTPAYLGTAIGDVVLNETDNTVLSAHITQLIYFLKQETPEFLKYSSDFSYAIEKFILHRFQSDLIDLSFMHYQSLQDGLNENANSFGINFVISFTTLFIFSIICSFAVRNRSGFKVDWIRSKPLVAICGLFNTLIALLASFGFLMLFNVQYNVLNTIIPFLIIAIGIDDMFIMNACWDQTDPNLNVEERMAEMMEHSAVAISITNITDILSFFIGAFSSLPGINLFCIYAATAVIFCYTFQLTFFSGFTAIMGHCENEERHSIFLYKVKKSNNEKKCSKVHDLTLDNIRSIYISDDVLPPMSIDEEKHVPPNEVIPGKLFSKSIHQPNVLVKKVSQSTSIKDERIIEDGSAAIRRFFSNKYSPFILNNKIRFLTMTIYVLYLIGSIIGSSMFREGLEPKNLVTNTHYISKYFSDMTMFWEKGPQLHVLVKDKVNFTDPVQRGILLGLVNKFEHTEYTMSREGTVFFLLEYMNYLEQLNAEPENTDKIWNKKLLKWLKNTGAANQWEQDIKYNDNKTQIEAFRFTIAMRNMVTPNQHKLATKLLREIADECPLKVDVYHEAFPFADQYLIIMSSTLQNVLISLFCMISISFLLIPSFPSAAIIAIMICSISCGVFGYMTFWGVNLDAVSMISLIMCIGFAVDLSAHIVYAFVASPGINSKEKVTAALAHLGWPILQVNSFLYIIMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B260</accession>
    <name>A0A0N5B260_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B260"/>
    <dbReference type="STRING" id="174720.A0A0N5B260"/>
    <dbReference type="WBParaSite" id="SPAL_0000016300.1">
        <property type="protein sequence ID" value="SPAL_0000016300.1"/>
        <property type="gene ID" value="SPAL_0000016300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF77">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000016300.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47188" checksum="C0728F826472C024" modified="2015-12-09" version="1">MSGQTNFIIDNIISNINKSDDFDGDGTSTISSNVISLPFTCKVFAVILYTLLSFVAFIGNLMIIIIILYFRKLKNGTNMLIMNLAIADIMIALICMPFSYWHVIIFEDSKWIFGSLFCKLLNFFQATAVFSSSWTLVAISFDRCLAILFVMSRWNKLNRKRALYVIFIIWAFSLLMACPLYFANEIVPNGIDNIETCVEKWSLLKFFGSDEEKIVSMYNKSLFALQYCMPLLVLVVTYTIIGFRMWFSGVPGGDNCSHVVKNASNKTLLQERHESVKKLIPMVILISALYAGCWLPQNLLMNVLANDTEILTHPYILYMWWIAHTIAMFHSVVNPFIYYCQNKRMREGLRYLLRWLPCVSFSEFKLLSYPNQRGLCSQRMYFNMISYNVNSEKKPTMVVGSSQSKTSCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B461</accession>
    <name>A0A0N5B461_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B461"/>
    <dbReference type="STRING" id="174720.A0A0N5B461"/>
    <dbReference type="WBParaSite" id="SPAL_0000086300.1">
        <property type="protein sequence ID" value="SPAL_0000086300.1"/>
        <property type="gene ID" value="SPAL_0000086300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000086300.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12253" checksum="507916F454C6E2B8" modified="2015-12-09" version="1">MSSHYQVKIKEGCIHVSKSGTVDVTIGSTSVDASLGISSLNGHPNLSNSGCTANFGVFDIKFHGSLLDDIIDLFRKEIEKHFKGKIEEVICQEIEKVESDQGNKILESFPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4E9</accession>
    <name>A0A0N5B4E9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4E9"/>
    <dbReference type="WBParaSite" id="SPAL_0000095100.1">
        <property type="protein sequence ID" value="SPAL_0000095100.1"/>
        <property type="gene ID" value="SPAL_0000095100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000095100.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57076" checksum="CA0977E06F07F6A5" modified="2015-12-09" version="1">MLIIFKNYILFKLFLIDEKDKYFLEDYKEFMFECKQWQQKTPNNISYNVSIKPSSSKEIVFCIVLQLLCGIQISVFFTSMWQYIVSVVPTFSMHFYGLLIAIFSVGQAISSPLFGALSNKLGSRNKIVAFALLLMASGNLLYACLVNLKTDWVPVAAVAARLFVGVGNGILSVIRGFVATVGDKRKRSSNIAAGIGSFVLGVALGPTIPMMFSIFGSKGYKVMGMVINLFTAPAYFNVLLFLIMTIILIFFIDLSDKHLNLSDTASLISTADDETGSTRKEEVSKIRLIPTISCIFLYVSIQCVSTNDEVIAAPYTIAMYNWNSTEAVRYNGILLTFCCILSLIFYALIAWGPLLEADKRKVILCGLVMFIIYHAANMPWPFYGGPLKYLPENATGFDEVGGCLRSYEWCKDAKRVPLGVYIISVVIGFGLGYPLTSAPLGALYSDILGNCKQDFMHGVMEFFGSLARCFGPILSTYLFETTGYKYAMGLQIVILSLSFLLFVVFYNRLVPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4N5</accession>
    <name>A0A0N5B4N5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5675 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4N5"/>
    <dbReference type="STRING" id="174720.A0A0N5B4N5"/>
    <dbReference type="WBParaSite" id="SPAL_0000103600.1">
        <property type="protein sequence ID" value="SPAL_0000103600.1"/>
        <property type="gene ID" value="SPAL_0000103600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000103600.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13789" checksum="7D68F5715CFCEB5C" modified="2015-12-09" version="1">MVSSRARAGDDMFITCNIGCVPVINTKSGKNLICVRESFQGTTCKTQKKYGCGVGEHILKDYNGEVVSTAKTQGCFTERDEKILKERGVEIFKMNTEGTMTLDTGKRLMIMNGRRCNEDNCNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B565</accession>
    <name>A0A0N5B565_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B565"/>
    <dbReference type="WBParaSite" id="SPAL_0000121200.1">
        <property type="protein sequence ID" value="SPAL_0000121200.1"/>
        <property type="gene ID" value="SPAL_0000121200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000121200.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8545" checksum="12FEBD99CC20939A" modified="2015-12-09" version="1">MSITDVTYFLYIELLICWNFNLFVSIFNLHILTVYLLYVFFMFLSIYYFFYYLFRKHKYIKIYICAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B605</accession>
    <name>A0A0N5B605_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B605"/>
    <dbReference type="STRING" id="174720.A0A0N5B605"/>
    <dbReference type="WBParaSite" id="SPAL_0000149600.1">
        <property type="protein sequence ID" value="SPAL_0000149600.1"/>
        <property type="gene ID" value="SPAL_0000149600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF74">
        <property type="entry name" value="ZINC TRANSPORTER ZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000149600.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38152" checksum="E294811CEE6A350E" modified="2015-12-09" version="1">MSDIILQVVLAIIMLLVTIFAGLIPLKICKKLMSKDSTFSKSSSKIMTLLTCFGGGVFMATCFLDIFPHMLEEYEKVQNLLNQEFNYPFPYFFACIGFFLVYGIEEFSIKLFGIKHSHDHDVFEKPEKTSPNDIELCTTGDKNNIEKTNEDYYTLQSHHNAIDESVTYMTNSDPKESGILKTITFTFVMSFHSLLEGFALGIQDTKANIITLFVSLILHKGIEAFTVGLQITKSNTNRIKFVLITIILYGSMTPLGTLIGVAFKNANINETSKVILCNLLEAFACGTFIYVTFLEILATEKTKEKYPIWKLTAIFLGFSVIATFQALDGLFIEDESSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B619</accession>
    <name>A0A0N5B619_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000150900.1">
        <property type="protein sequence ID" value="SPAL_0000150900.1"/>
        <property type="gene ID" value="SPAL_0000150900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000150900.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16768" checksum="2D530633C845BDC8" modified="2015-12-09" version="1">MINTSFIFXACVKNKIGALGCSNEENPGNLTIPLIPVMPHNDDSGIDLSNDDSFVAAPAVPQMQGPPELGQYIMCLEECSMVEPLNIIPKSHRSKRSPVSCAFLMKCALAPPDEKANAAFKECEKEYNFNEKNRAKESCECLKNAGITSLSCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B702</accession>
    <name>A0A0N5B702_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B702"/>
    <dbReference type="WBParaSite" id="SPAL_0000183384.1">
        <property type="protein sequence ID" value="SPAL_0000183384.1"/>
        <property type="gene ID" value="SPAL_0000183384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000183384.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8779" checksum="33CB08EA101F8CE9" modified="2015-12-09" version="1">MERSSRNSRGSVGSVSSVHSDPGSFSYQSQGTLRRGSLSSTQNHKVSVRRRKGHGGRWSSRLGKMLSKRRSGQYRLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B731</accession>
    <name>A0A0N5B731_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B731"/>
    <dbReference type="WBParaSite" id="SPAL_0000185900.1">
        <property type="protein sequence ID" value="SPAL_0000185900.1"/>
        <property type="gene ID" value="SPAL_0000185900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185900.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15786" checksum="414A4A0DD07570DF" modified="2015-12-09" version="1">MNYLNVSIFIIATFLIVTGEFFFLPKHSKRHEWESKSTKDRKILRYAKDAVKLYNEINHSMLTLNQVLAARRIYEGDSKHYNLKILANNDCNRKMYGCTEEIIADIIKNNEHPHKLKISVRNYWRENNVNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B733</accession>
    <name>A0A0N5B733_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B733"/>
    <dbReference type="WBParaSite" id="SPAL_0000186100.1">
        <property type="protein sequence ID" value="SPAL_0000186100.1"/>
        <property type="gene ID" value="SPAL_0000186100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000186100.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15037" checksum="91BD30CC49434FFF" modified="2015-12-09" version="1">MNYLNIFIFIIATFFLIIEAFPGVYKVNEWKKTNPKRKKIEDLGKEAIKVYNKKHGPSALFNRVLKAEKQYNGYSKNYHLQILVLGKCDENTAGCLQTLDADIFKKHQNPDEPEFYVYKNSDENGINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B788</accession>
    <name>A0A0N5B788_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B788"/>
    <dbReference type="STRING" id="174720.A0A0N5B788"/>
    <dbReference type="WBParaSite" id="SPAL_0000191600.1">
        <property type="protein sequence ID" value="SPAL_0000191600.1"/>
        <property type="gene ID" value="SPAL_0000191600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF111">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000191600.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37733" checksum="9150E958D65B1454" modified="2015-12-09" version="1">MEEIVKVTSYKIRLYVYFIIVIIALIFGTVLFYYIEKDDAKNAYESYINRCTTTREVAIKNLNNEFMEKKQLLLMNNKIDSFIRREFHDNVVSFVKEIDKCHRKKESKKVFNFDMSKSAVFTFSILSRIGYGTVYPHNYAGHLFFLIFGLITIPIFISFYIELYEHILHNNQKDNDKNVPKKASRIIMAMIFLIIVGLSSILNHIFELTLIHKSITIGDHFLFFYDSISKIGLGSYEPDNSVRFLLVEVPLMIIGIAFFSLYVNTVEQFIRHDLPYIITKKFKENKFFKEKYLKYIVKDVEKRNLYLLTDYRNTKQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7J7</accession>
    <name>A0A0N5B7J7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3533 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7J7"/>
    <dbReference type="WBParaSite" id="SPAL_0000202200.1">
        <property type="protein sequence ID" value="SPAL_0000202200.1"/>
        <property type="gene ID" value="SPAL_0000202200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF8">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000202200.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38219" checksum="61D9ECC65E97D9EA" modified="2015-12-09" version="1">MTDPYACLRASSICVAGWSILFCLIQYAVLGWQVSYVKGLTWEYENRQVPFNHGLDGFAARFPGLYALYTETPERRRVNALFTIVVICLGLNFIHLFASISLLYGTIKKRPPAIWPWFCSVVPNIILTTAYAVLWWSGDVFNEQLTMSVAEFIMSIGINSICFVVILFYYFRLTGSMTSTVPAGFQSRPESRNMSRPPSQKGYRRHDPHFRSSSKERPFFSDWQLNDGQREIYPKGNVPPWRTEWDPEPPKQFVRQYRDSRRRIERESRSRERSRNKSLSPPRPLSRPQSRSQYKCVPLAYHPDDLQRSKSRSATQLHHGHRSRHTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8G3</accession>
    <name>A0A0N5B8G3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Lipid-anchor</topology>
            <orientation evidence="2 13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8G3"/>
    <dbReference type="STRING" id="174720.A0A0N5B8G3"/>
    <dbReference type="WBParaSite" id="SPAL_0000233600.1">
        <property type="protein sequence ID" value="SPAL_0000233600.1"/>
        <property type="gene ID" value="SPAL_0000233600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="15">
        <location>
            <begin position="14"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000233600.1"/>
        </source>
    </evidence>
    <sequence length="1238" mass="142201" checksum="1609CB5174B8891F" modified="2015-12-09" version="1">MFSREESRVRLGRIFNLLDATILEYQHPITGLFENNPTNFPNHAWVRDNLYAVQALWALYRAYKKCAYSDEEMENVKKIGYSCIKIMQSIMECMIRQADKVELFKLHQRPHDALHAKYSVINKKSVSGDLDWGHHQIDAVSLFLLTLAQMTASGLQIVRNFDEVAFIQNLVYYIEIAYRTPDYGIWERGDKTNQGITELNSSSVGLAKAAMHALREVGDLFSDGSKSSCIHIVSDEIEQCDAVLSSMLPRESFSKEVDAALLSMISFPAFAVADIELITKTRAAVLELLYGKYGCIRFIRDGYKTVLEDPHRLHYNNSELQNFENIECEWPLFLLFLIIDSYFNKDEEKLKEYWTRLDHCLVTDENNKDLNLVPELYRVPLNKVQAEKRDPKSQEREVGGLVPFVWAQSLYIICLLLRENLITAPELDPLSRRLAITEKRPPSEVQVVILAETLDVKQQLAERDIEVQTLDEIDPIFTVQPASVFQKILGRFGECNKLKLTGRPEDRDIGLLTTSILYQIGQKFVVFTPQFMDRKRSHLFYDIRILMDEWASELQYIYTSWNSANMSGRPLVVLVVSKHMLHNKDIDERNEDGLNSIEMKATVIDTILKIKNGYIDGSRVVMGHLHSFFRTTAISKLHLHDHYSHLINHSYINGSAHRSYLDKEEINGPNSDTPRREESGIKRSNSIKDRKPKQFNVVHETSLRHRSMIFDSNDVDLIQLRLAYNSAKMNSNNSIPSSPDKLIETLSDTRSSTSPMEIPANAPEFLASEYAASPFGEESWLTNHQKNELIDMSDNSLIDLLNETNILEEQASIIHCLWIKRGPNCQIYIKSHDASVSVRELTEEVYRKACIGREWTWVRISAGLLDKQMDELTKNVTHLMVRQKQLTVGSPSKTEEAITCPKTREELRIIIGRAYRDDKNGMTLAQEVIVALGSLVRTDPKLFIEMFRLRIGLIVQVMASELARIKHLGAEEASLNLLHLSPFEVKEMIHALLSGRLLEETSSRSSVGVGIREKRTGMESFRKQIEERKSLRRSLRSEVSKHDNIVNAKEESSDDSELDDDYQYGIWLRHRRIDGALNRVPQSFYATIWSTLRRFYRGITVGGHYLDWSLTQEMTTREIKFSLQVEHILNQIVEPEYREILVEAFMLLGNIDKLIQCAPRIDHSQPFELDRIVRVANALFVEHNREMNTIVMECCGSNNFCDGARGICQYFYDSAPAGEYGTAHYMIKALMDLFASDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Z8</accession>
    <name>A0A0N5B8Z8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8Z8"/>
    <dbReference type="STRING" id="174720.A0A0N5B8Z8"/>
    <dbReference type="WBParaSite" id="SPAL_0000252000.1">
        <property type="protein sequence ID" value="SPAL_0000252000.1"/>
        <property type="gene ID" value="SPAL_0000252000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000252000.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="87836" checksum="8EBD17B59068F4C6" modified="2015-12-09" version="1">MNDEDLMLQNMIDNYQREVLKKKQANICRASSAAKCISMVEKRKNLPTSSHSQPCLFSMVESKSSPTSQGPSAQGSCDDKKILESRSESTTFTQNSKLPSCFVIPSSQQQQQHNQFIQGTSGQNNFQQPPIYQFTGRDNTLRGEFFNIQNENKQLKIINNQLREKCIKLDNLTIAYDNIEKEFDRLLMKREKSEKVHEVTIEKLEKQIEILINENNSLQKMLEEKGKNEHQSDVNSMKIFINELMEIKERQNIEIEAQNATLQEQRNHIDMLEKALFNAQERYNLKERQLSEMAIVNKSLQKKLEEIMVRENDLVKEIKKLKRGNDEINEIQKLRRLIFVKEENISNLKKKLKEAEKSCGLQDETDEDGEYDDEDFEDPYIPSRSTSHTQKRFSNNNIHMDNLDDMMKEKSTLKQYQDEKDKLEQRLRYANNRNNERQRLFDDFNTQYHQDGCRNNNKTTRRSEMQNIYTLKQQQHIPSTISSNYSSQNHSRSLSSGNEFLQISIPPNPIEAYRDNLLRSIGSNNNVNHDNDYHLTNYQKMYRSHQQMPLHMSPKSSNYNSDNLTSEEYLESKRHEIPYNDDQSNFENVLVIDTISNNIQTTSPYTIENAINSQINIFTSPTSGNGVRRNNGRYQLSFKSSSSSSSTSNSKTNSVVISEPQTPTNNNINNNNNIIKSTSTKHVLLSEGTKSNSTNSMAHSKSSSEAENTEEITLDKIEIPHHTCIGKTIEIPNNSHYIHVQTNHNTLVPKTIIVNDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B943</accession>
    <name>A0A0N5B943_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B943"/>
    <dbReference type="WBParaSite" id="SPAL_0000256000.1">
        <property type="protein sequence ID" value="SPAL_0000256000.1"/>
        <property type="gene ID" value="SPAL_0000256000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000256000.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21858" checksum="791410BDD48C21B2" modified="2015-12-09" version="1">MANGLKKVGDKKSLLYYNYNLGENKCPNKGNLHLLNEISSFGIDGNSTMRDMSFDIKEVPRYNSKLSSVQSEKDSQKIVYNADTATTIPDITKSFKDSPIPISHSTPRISNNVSTNTIHEKANLDNQTPVIHKKTTPSIVNNFTPNDTTANQTNDSTSNIYYSILSNAAVTNRVHDTPVRPFNKETNLMDKIFGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAI7</accession>
    <name>A0A0N5BAI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4834 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAI7"/>
    <dbReference type="WBParaSite" id="SPAL_0000305400.1">
        <property type="protein sequence ID" value="SPAL_0000305400.1"/>
        <property type="gene ID" value="SPAL_0000305400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000305400.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11999" checksum="1F11086E196B5DC1" modified="2015-12-09" version="1">MALYVYCLIIILYWIYALLFNVIQKIYIKVMLYGKYFEKTFRKKNICSSENSSGQKSSSRFAKIRNLLQLFKKKDSCQIPDDDFMEEKDSNLLVNENDDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAP6</accession>
    <name>A0A0N5BAP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000311300.1">
        <property type="protein sequence ID" value="SPAL_0000311300.1"/>
        <property type="gene ID" value="SPAL_0000311300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311300.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71971" checksum="0D3548A0E4441E5C" modified="2015-12-09" version="1">MSGFPQCGESCVVWGEFTLSEEVVDSQIVSVLNQLEEGNHIPGKERFTEQEKEFVVIQARGVYTDKPEKLVENVLTIARIIKRAFEFGKLMMAEGQAVANNFNFCRMVKKFESKDGSDIKPFLEELDTAFMLDGVTDRNTKVNVLKFMTNEPVREFLGGITAAVDYENVEVQLRDRFSRKLAIQACAGAVRLMEINCKHDEFAMSCKEFRDLKKKLGVTGTRDLKEALYNYLSTNIESCQNFEDMIVAGETFLKLLSKRRGRKSPEKVEEVDKKPESQRFQGSCNWCGKKYHKENECWSKRNGKLKVTEKLEIGSTDVKINVMDKKNNTSLVIEEFMFGKVLKKGLVDSGAAVNFVKLSSYFDIQAGDPEVKLLPYKKRCLFGVKEVIPVGTCMLGILWRDKQLRLPFIVLLDKDVSQKYDSIIGVKLCLSLKLMCYGYLRRSQLRILLQKMVIMVRLNNIVIEDACEVPEKGNVLKESQNVLTLDVNEDLKESTVGRAQMPELDHELSSDGVQSGEKTCRLVRDKKNLDKPDALKRVMEKPLICYEDPGKKFLRTNTSDVAYDAGGCQEREIGEGKVENGPLLELSMKRRNFKKGRNTAVLDSRLACKLVSGNLCESTGINEISEGKGTEEAQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBQ0</accession>
    <name>A0A0N5BBQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBM20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BBQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000345600.1">
        <property type="protein sequence ID" value="SPAL_0000345600.1"/>
        <property type="gene ID" value="SPAL_0000345600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000345600.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43840" checksum="D4B977B71F411257" modified="2015-12-09" version="1">MFVVGSVDKLGMWLPQNAIEMSVDSDDSSLWTAKIEIDKNQLIEKIRFRYFTGYYLLSECNSNGRIIIVSLWESHIKARKFNLKLDDIGGVINVNGVHEFGVLEGRLLINHGWLVNKEQCEIYLRIHGEALKFFKERHKNKLYYIKVTPFDLRYKEEYSYIPSDKMMPFWRQSSFYVKTTDSIDEESNLQDNEKEPLPILPTFSNTDVAIISSDLPEYNDQPKSGLLFNNKDDYFVFRTTTSSIDNLAFRFDFFIEADNVMNAIKKNPTHPGYHRLATAICMPSSIIGTIGDMIVPILAPNQIPIGQITIDYLLIKPINNTDQYQSMEHTYARYWKKRKTVEVGHRGMGNSYTQKAVARENTVFSLEKAYRNGADFVEX</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC52</accession>
    <name>A0A0N5BC52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC52"/>
    <dbReference type="STRING" id="174720.A0A0N5BC52"/>
    <dbReference type="WBParaSite" id="SPAL_0000360100.1">
        <property type="protein sequence ID" value="SPAL_0000360100.1"/>
        <property type="gene ID" value="SPAL_0000360100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000360100.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33782" checksum="302E8FF3069718A6" modified="2015-12-09" version="1">MVVSDNITGGVRILNNGVKMPYVGLGTYKIVGQEAIDIAVKGALAAGYRMFDTAKYYHNEKELGIAFEKYLPEFNLTRDDIFITTKFWLSGSDNDSATKKHVKESLELLKTNYLDLVLIHYPKSDDCDNDDPRNYDHRKDAYLALCELYNQGIIKAIGVSNYEVFHLKNIPSYSDIVPTVNQCEFHPMFTRDDIRKYCKEHNIFFQAFSSLARFHDDVIKNKTIVEMAKKHETSVPLLLLAFALCQNVGVVPKSTSPERIAENITATKIKLSQGDVDVLNGLNINQHYIRCTGWLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCK2</accession>
    <name>A0A0N5BCK2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCK2"/>
    <dbReference type="WBParaSite" id="SPAL_0000374900.1">
        <property type="protein sequence ID" value="SPAL_0000374900.1"/>
        <property type="gene ID" value="SPAL_0000374900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000374900.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24670" checksum="4AC5570C8203114D" modified="2015-12-09" version="1">MAQEPQSPWSRWDPEGFQFIPSITTTVQSVLNRQYDAPASGGVSGSVYTTVMQPIQGTLQSQRLSPNQTNIVNCYYGFENTLERQVISCYKDLGCCDKGCCEDASWNVKYGFSVALIVIFSVIVLAAFAIWFVIWLINRSKDKKLREEIEYHSDQVNNPPVSNQVHMPSPYNSQTPYMPTTYNPEYYDHHQQDMVNSHHMHYQHGDDRQDCYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCN4</accession>
    <name>A0A0N5BCN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCN4"/>
    <dbReference type="STRING" id="174720.A0A0N5BCN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000377900.1">
        <property type="protein sequence ID" value="SPAL_0000377900.1"/>
        <property type="gene ID" value="SPAL_0000377900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08676">
        <property type="entry name" value="C2A_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04009">
        <property type="entry name" value="C2B_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF9">
        <property type="entry name" value="BAI1-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="142"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="682"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="916"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000377900.1"/>
        </source>
    </evidence>
    <sequence length="1206" mass="138134" checksum="E978897B3A75106C" modified="2015-12-09" version="1">MNMEAVTSNVASKATIISRKISTAGAWAGQQFSRAANFIKTQSMALNDDDNSILNDGSQIHKQVQASDNHFFEQFSPIQLTNEDSKNVDEQYTIAKITINENEKHMHELYVEAMYTIQHKIGNQTDLTQSQLAKYVQSAFEVDEKLHKSLIARAARQKAPLVLLNVQLIEGKDLIAKDINGFSDPFCMMGIVPGEKKTFKPVLNPEDIEVTPWDFEDLPDDSGLTQKVGKPTSPTSPNENNKKHRLSRIGGSFRRKLAGKKTQKTEDGEVTNIPAKVIKASSVQKMTLNPKWNEKFQFIVDNIQCDKFHLDIWDHDDDERSVIDAVTSLNEISGLRGLGRYFKEVTQSARAHSNESVDDFLGCVNIEISQIPPEGMEKWFELEKRSERSEVSGSIKLKLWLSTKEERVNSNDDETIDVKQHIQLIRQFALHEIRCSQQPVSSFSGLLPDPAKAILYQHAIQGDLTPTHQLMCQWLAYSAMIPIGINFHLLNDIAGRLIDKWTPLDLDKDEENMLACSFNDFDDFVKGYLISHLKNVNVLKKSQVDRFGEILKTYINIKDSSLFDRCVPFGPSKNTFLMECLVTASKDYFKWYFELSKDETNSCKILLKLIVHLIKGCQKIKYIEPFFKSNTEIDYTLTLYSNWDEMLEEYMAIEQTNESKSSLKQLFNNAHDGEEVVILSIMHLHCLIRDFDSFKPTSYKPKMMRSDWRYQFDRVVAKWIDIARIKAFSRVDLSCKLDSNLQLTSSEVKYTSSYVDICHIIDQLANIWEKLYVYDINLRADLLVKLVQFICKLVEYYIDKIMGELAQDGFCGDLQFYLPPALVSIFCATINNAEQVRRCLVIHDKLQLEELAEKFEKKIKKPAKFKEQIENDLDVCDRYIAEQIESTVFRFVVRCTDQMKKHVFHLAWSPTACPVDVSLKPMTDLLDAELSSIHKYLLHKNFLRIMHAQIGILIKLFNDCINENIGLEPIFYQRLYDAWGVLTDYFHADGKGLSLEAFDGMAGHRKIISILSLNKTPTVKIIEKYYSSLLKKQTDAQECKYGILNVRAYYNQKSQTLVVDIIGAKQIIPLDSNGLSDPFVVVELVPHFRFPLQIPAKTKVVSKSLNPIFNETFEFQVPPTQSPCAMIHFIVMDHDFLRSNDFAGEAFLELTEVPGFGNAQLSSTLRQFNLILIHPTDKFQEALSVLESRKDDKEAIDFLKSLSISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCQ2</accession>
    <name>A0A0N5BCQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein Di-Ras2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BCQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000379700.2">
        <property type="protein sequence ID" value="SPAL_0000379700.2"/>
        <property type="gene ID" value="SPAL_0000379700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000379700.2"/>
        </source>
    </evidence>
    <sequence length="226" mass="25264" checksum="CB922DC85E51C118" modified="2015-12-09" version="1">MCKKNYLNHFCIGVEVPSSVVSSSTSGRLTNESSTSDYRVAVFGAGGVGKSSIVLRFIKGVFNESYVPTIEDTYRQVISCNQKNVCTLEITDTTGSHQFPAMQRLSITRGNAFILVYSITSKQSLEELGPIILMLKEVKKEKVAEVPIMLVGNKKDDQSKREVSTETGQKLADKWGCGFIETSAKENENIFELFQTLLSKEKKRQLCLNMDKESEDKNMKKGCFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD95</accession>
    <name>A0A0N5BD95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BD95"/>
    <dbReference type="WBParaSite" id="SPAL_0000398400.1">
        <property type="protein sequence ID" value="SPAL_0000398400.1"/>
        <property type="gene ID" value="SPAL_0000398400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000398400.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17570" checksum="81A3CCC8A3001D24" modified="2015-12-09" version="1">XSSAFKEHTEGQNHQSRLNMLVNSGSSNTSTTSSRTNLVDQRSSSSSSNSSDSQMNGRKCNEILKKCKFCDFTSNNEHEQIEHISNHSHIFDLNTSTGTRNMKITTAEAPPCQSSKLEITDDCNEGNGEDSFSNDLSMKLLPKDSRLLCPECIFSTAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF0</accession>
    <name>A0A0N5BDF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000403600.1">
        <property type="protein sequence ID" value="SPAL_0000403600.1"/>
        <property type="gene ID" value="SPAL_0000403600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894324" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000403600.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21354" checksum="846634E753160785" modified="2015-12-09" version="1">MLMKIFCLFLLFTPSTSFYTNPNDSNELKIVTLSDVIQKHIKIKAGEDIKPGLPYQTINVISNLQPNNDLYKEKKIIIYDNNINNFKLNENQKEEMITNQEQSNTIKDTFPSNFGDSKSANFKKISRRSISNAVIESAHCEHMELIECDSYETNDMKCLVTATGMPCCVCTGKLKSLRKVKKWIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE10</accession>
    <name>A0A0N5BE10_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tyrosyl-DNA phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE10"/>
    <dbReference type="STRING" id="174720.A0A0N5BE10"/>
    <dbReference type="WBParaSite" id="SPAL_0000423700.1">
        <property type="protein sequence ID" value="SPAL_0000423700.1"/>
        <property type="gene ID" value="SPAL_0000423700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000423700.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52603" checksum="681E944D85C90061" modified="2015-12-09" version="1">MDDMHKTKKAKLANQDDIATISQGMHLNKLANIPYYNQIKSVCLKEFITTLQPKLSYHFTFYASESFLDEIYANYKIGLENTTLIIGVGRDIIKAVKEQEHENKSIKRKYVPMEPYASHHCKLSIFFDHENRPHVAIMTGNLEEDEWSSITQALYYAKGEEKAHDYESSKDMFLIDLLQYLESGYKNQIFFEETIQPLMNNLKCWSFLHIKDRLIFSIYDTKIPKFMKDYSINKIKLLLEENKEKLREISYFVVQCSSIGFMGISERKWLIDRFLKNITNGQLNSLNDLKIIYPSLDDVRNSINGYRNGNLFPYTKRNKEKQGKYINPCLHRWSSENLKRTLYLPHLKTYTAFDSNNEPIYQIVGSQNLSKAAWGEIDDYGTFVMKNYEIGVFTLDRKSMVIPYDIPLVKYQSDQQIWTGNESHMEPDCHGRIYVVSDDEESFIQYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE74</accession>
    <name>A0A0N5BE74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE74"/>
    <dbReference type="WBParaSite" id="SPAL_0000429850.1">
        <property type="protein sequence ID" value="SPAL_0000429850.1"/>
        <property type="gene ID" value="SPAL_0000429850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000429850.1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4554" checksum="C840DE81479350C2" modified="2015-12-09" version="1">MNNKNTSSVDKEIKTSKLFYQNMFIFITFISIFSKMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEY8</accession>
    <name>A0A0N5BEY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear pore protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEY8"/>
    <dbReference type="STRING" id="174720.A0A0N5BEY8"/>
    <dbReference type="WBParaSite" id="SPAL_0000455800.1">
        <property type="protein sequence ID" value="SPAL_0000455800.1"/>
        <property type="gene ID" value="SPAL_0000455800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000455800.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="52642" checksum="25BF7C6C6E8A120A" modified="2015-12-09" version="1">MNIDTHPTYESLCFIERVFKFLGKQNECDVADVYEKLDFGIYKAIVRYGKNLALDGRKSAKFAKKLKENFIDTTLDDGTEGKNNKLITFIDDLLYDSQFMDQKYLDLDKIDIGTLFKIYEPISSHREELLLQKAMYNYCRRSFTKKKLVNELSFFLMNNSLESIYAESNDYSQLINLAGRKIYSLHDDSRINHKFFCDWRLDDLMYTSGLTMILQYQKFCNVNASLTILEYIQTMHSRERIEKCEELFLLQEEIYAYHYEKKNEEYGPAYDNFVVTSVKKYPKFVNLLMVYLRRCGKHRTTQIDNSFIESLDISKLPKMMAIIYNEYLLFKKELNKGISNYPPYPSFDRFRETILKYADEITRFTLSPIIWNLLLKLESKYGSRESLKRSFFRGLESVGWSKEYYMKYLLCESSAFDDVFQLLIEKGFRVRCLKEELSILLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF89</accession>
    <name>A0A0N5BF89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF89"/>
    <dbReference type="STRING" id="174720.A0A0N5BF89"/>
    <dbReference type="WBParaSite" id="SPAL_0000465700.1">
        <property type="protein sequence ID" value="SPAL_0000465700.1"/>
        <property type="gene ID" value="SPAL_0000465700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000465700.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30869" checksum="5EC1103809EBE50A" modified="2015-12-09" version="1">MSISATTRFKKRLGEPKHTRGRWNCHDYFYNGEQVTENNNGKNNKDIVRLRTNTISSNREFHTPGEGIKNSEFVNPFPKVDDLVGSPSNSSAYMSIPSSQSQKYSASVSPCMSHISILSYDKTVNSFSMDMTDESDDENSTPLSDSFSYSPASSTCRYGKPKTVYSTLPRKIITPLIKTDNEDNESFCGSNNATPDYQNSPSIMTAGDLSSQFKFEKALKNTPMSEKSFKMLVNRNDDCPDIENKEESLDKNANVKLPTMISDKKNIDYKQSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFQ2</accession>
    <name>A0A0N5BFQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BFQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000481800.1">
        <property type="protein sequence ID" value="SPAL_0000481800.1"/>
        <property type="gene ID" value="SPAL_0000481800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000481800.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39626" checksum="68D23F9A671A2D68" modified="2015-12-09" version="1">MAKSDKVLDFVTLLFNLCWKTMKFPKSSRLTKVALIFKKGSRQSIKNYHPISIISHVYKSFIRIWMGRVNNIVNPQIRSYQMGFREKRSCIDAISCLENPISVRHEFNLPTILGFLDFFKAYDRVYKEMLFKILISSYNVPLHLVKILDSLYSSNYFMFDPEYGNKIKCRVWRGLKQGCPASPMLFNVILEFIYRNALLDDSLNPLPNFGVAFNRLRVVGISYADDTTLIADSDDSFKEMLSAFTYHSKRVGLNINLDKSNYIAFKIEMENSFKITPCSSFNYLGRKLSFVECRPFIRQIKVRGYKALIVIRPALPTVSLKARRFLFQSTIKSCYTYACQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHA6</accession>
    <name>A0A0N5BHA6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000535000.1">
        <property type="protein sequence ID" value="SPAL_0000535000.1"/>
        <property type="gene ID" value="SPAL_0000535000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="372"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="613"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000535000.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="88092" checksum="51FC686E4C06E3B2" modified="2015-12-09" version="1">XTSITSKGKVNIKRSFDPLLDITDRFGNKVNNDFCVTYNPYLSLKYNSHINVKICESVLSPKYLFKYTHKLNGDKISADVVETVESKDEVKLHIDGRYVGPSEAVWRIMEYPILYKDWTVVRLAVHLINEDCTVADEMNNGNNNCFKAEKGYKSTLLAFYNLNKNDINARKYLYNEIPEYYWFDLKTREWKLRHRQRRTIGRIFTVSPMNVELFSLRQLLLHVPGATCEGDLKIVNGVQWPSFRDAAIARGLLDTEDNYNELFEEACESAMPNMLRNYFGLMICYWPSFTRHYDTFIKFKNYLIEDYLMKYNGNEERAEAQAIFDIRNVLQSNNFNGYTDLPEVNFDVVEIDYVEDKDVLKRLGDENLKSANEEQRNFINRILNIIVNNFSDKRCFFLEGPAGTGKTFVYTTLYYLLRAEDKIVLNCASTGIAATLLRNGQTVHSMFSVPITLFDSNFRLSMLNKLRTTMLEKASLIIIDEAPMLSNPLWNVHFETVKLTRNMRVKEDEIDFAKWILDIGDDALQKNEDGEVDIPLNIQSTGNLVNDIFGDKNESILEKSNYAILAPTNAIVETINNEVLNTLPGDVEKIFSADSIRKDSDTNENYYNMPIENLNQLTPSGLPPHVLNLKVNAVIIVLRNLNIKEGLCNGTRLRVMKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEFPFTLARKQFPVRLAFAMTINKSQGQTLSKVGVDLTTPVFSHGQLYVAFSRVKSPDCLLVKTESDKAKNIVYTEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHI1</accession>
    <name>A0A0N5BHI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHI1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000542200.2">
        <property type="protein sequence ID" value="SPAL_0000542200.2"/>
        <property type="gene ID" value="SPAL_0000542200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="419"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="603"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="881"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000542200.2"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114720" checksum="4BEDC59052DC4D10" modified="2015-12-09" version="1">MNSRVSEYEFLDSTPYKKDLLIEEDNNSDLNYYYDVYNNKNIIHPNDNYLNTYSTPNTLKKFPISQSFYTPTITLAKVSIHKSESEKCTKKEGYQRLSTLPTPYNYHGILNQDKTSPSTCRTTISSQSSSLRSSLNDGGNVNSDYSNVTRNKNYKIPSPVNEMKYNSTLSGKSNNPKYIDSNNLETVGYVNDNKKISKSNSHLKYYTFSNEDFTFPKKFNTMVKVKPENDKYYYGDPKKEGTKRCLMFTGVFFGIISTLMAISFMVALIIVANQKNTSTPDKNIDIFNVLLHEDVKRANDIGDDLLKEWDGENIKNSIRWLSEKIHVAGTDNNMAVMNHIEKEFTELGLEVTSSVYDVLLDYPNYNKPNTISYCDKKNNCEVLSDGLSDVLGDGELASQLGDDYRSKVQWLAYAKNGTVTGSIVYANYGKLDDYEVLDKKNISLKDKIVLVRYGGNFRADKVNMAGVRGAKGVIIYSDPHEYAPLLKKDNETFPHNIYLPDQGAQRGTLLKFDGDPLTPYFPSKDYVMRTGSEEEMRKQNLMPSIPATPIGYGDAIKIFNLMDGPKVDIDGWNGSMDTTYRFTGSAQITLDVHSGTVKRKIKNVIGRFVGSEEPDKWVMLGNHVDAWVKGSIDPNSGTATMLEAARVLTKVSKTTGWVPRRSIVFCAWDAEEYGLIGSTEFVEEYMKLLQNKALVYLNVDNINGNNTLLVKTVPLLYRSIVDAAKKVPHPNPDDVKQGLNTLYDGWQHYNPKGPLSGDKSIPEVKNPGSGSDFQRFISYIGIPVLDLKMQGAPFMNYMLYHSMYEVPWTTENLIDPTGKVFSSLGSLWLELSRNIADSLIIPYNIEDYAIKLDDFITQMEVVLKTYEINKAMGADKYSEKINNLRDAVKRFNGKAILLQDQIEAIRNGNLGVTITQQRLINNILQDIEKSFIIEQGIYPERALYRHAVFAPNQHDSYSGKVFSLILDPATEYKNYINIGDKKEAERWLKVVELGFTKLQYAIESAILTMDIGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIN6</accession>
    <name>A0A0N5BIN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIN6"/>
    <dbReference type="WBParaSite" id="SPAL_0000581600.1">
        <property type="protein sequence ID" value="SPAL_0000581600.1"/>
        <property type="gene ID" value="SPAL_0000581600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000581600.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33419" checksum="4D7C6D1F8804DBCC" modified="2015-12-09" version="1">MGVQCIICLESCTASGTIHALYSTPCGHVMGKECLEKFKEHLNNNCFNCPFCRKEIMVNNCHPIHGFVPEVKNSVTKSENTCKKLKENFSFSKNFSENINGTIKIFDEHNGNILIAGEIPSLFFSDHFIKLIVTNGRKIYDISEYKLDIECSCLCFNKSENGVIEFCVGYINGIVELYRYKVYGNNLKVLNEKKLINFDFISILFGTRKINSVCFLSNDSIALSVGKGMIRNWNKREEWLSKTGIINKCVDNKSDYITQLKKTNCDDCLGIMNDKIFVFDNHSSLLFQLRIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIV7</accession>
    <name>A0A0N5BIV7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIV7"/>
    <dbReference type="STRING" id="174720.A0A0N5BIV7"/>
    <dbReference type="WBParaSite" id="SPAL_0000588700.1">
        <property type="protein sequence ID" value="SPAL_0000588700.1"/>
        <property type="gene ID" value="SPAL_0000588700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000588700.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12981" checksum="2C8E6DC7E4E4B03F" modified="2015-12-09" version="1">MPALVNRKGPILLHDNAKPHVSKMTLQKLCELRYETLSHPPYSPDLSPTDYHFFKHLNNFLTEKIFRNDEEAKTAFEAFIESRTPEFYANGINKLVSRWQQCVDSNGCYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIY4</accession>
    <name>A0A0N5BIY4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIY4"/>
    <dbReference type="STRING" id="174720.A0A0N5BIY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000591300.1">
        <property type="protein sequence ID" value="SPAL_0000591300.1"/>
        <property type="gene ID" value="SPAL_0000591300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000591300.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19098" checksum="8EC0D8DDD7BB50F4" modified="2015-12-09" version="1">MAGYALKRLMSEFKQLTMDPPEGIVAGPVSEDNFFEWDCYITGPEDSCFANGVFPAKITFPADYPLSPPQMQFTCDIFHPNIYPDGKVCISILHAPGDDPLGYESSTERWSPVQSVEKILLSVVSMLAEPNDESPANVNAAKIWRLERDEFVRIADRLVRKTLGLPVTQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK79</accession>
    <name>A0A0N5BK79_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK79"/>
    <dbReference type="STRING" id="174720.A0A0N5BK79"/>
    <dbReference type="WBParaSite" id="SPAL_0000634200.1">
        <property type="protein sequence ID" value="SPAL_0000634200.1"/>
        <property type="gene ID" value="SPAL_0000634200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04122">
        <property type="entry name" value="Rab14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000344">
        <property type="entry name" value="Ras-related protein Rab-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030702">
        <property type="entry name" value="Rab14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000634200.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24160" checksum="D1D248FB8E88C907" modified="2015-12-09" version="1">MNNSNQYNYNYIFKYIIIGDVGVGKSCLLHQFTEKKFMVDCPHTIGVEFFTRIIEVSGQKIKLQLWDTAGQERFRAVTRSYYRGAAGAIMVYDVTRRTTFNHLSSWLQDARNLTNPNTVIFLIGNKSDLDEQREVTFDEGKQFSEENGLTFLECSAKTGSNVEEVFLSTANKIFQNIQDGSIDLNQADSGVQPRHTLSRPTPSGARSDGNDCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKH4</accession>
    <name>A0A0N5BKH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calpain inhibitor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000643100.1">
        <property type="protein sequence ID" value="SPAL_0000643100.1"/>
        <property type="gene ID" value="SPAL_0000643100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000643100.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9635" checksum="96238457E133368A" modified="2015-12-09" version="1">MADKSAYVPPEAFTGNGGIKKDASDVDLDDVDFFAKPAAGQTEKKPITPPPVVIPPPPASSPAKTPEPPKKAPIVYKKSTTYQKTFAGPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKK5</accession>
    <name>A0A0N5BKK5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKK5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000646100.1">
        <property type="protein sequence ID" value="SPAL_0000646100.1"/>
        <property type="gene ID" value="SPAL_0000646100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000646100.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="34571" checksum="FD59187B155C2FF7" modified="2015-12-09" version="1">MPNIKVFGGSSHKGLTQMICSKLQLDVSKASLKKFANKETNVEIGESVRGEDVYIIQSGSGEVNDNIMELLIMINACKIASSCRVAAVIPCFPYARQDKKDKSRAPISAKLIANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPALLEYIRLKIPNWQDAVVVSPDAGGAKRVTSIADKLNIDFALIHKERKRANEVEKMTLVGNVEGKIAILVDDMADTCGTICLAADKLVEAGASKVYAICVHGVFSGPALQRLNNSKFEAIVVTNTIPQEENMKLCPKIQCIDISGILAEAIRRTHNGESVSYLFSHVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL50</accession>
    <name>A0A0N5BL50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL50"/>
    <dbReference type="STRING" id="174720.A0A0N5BL50"/>
    <dbReference type="WBParaSite" id="SPAL_0000665200.1">
        <property type="protein sequence ID" value="SPAL_0000665200.1"/>
        <property type="gene ID" value="SPAL_0000665200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000665200.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13602" checksum="49025EDD7D9E0A14" modified="2015-12-09" version="1">MEPYEDSEYIWTKRTFEDPRFYTASFGKRSSPPKVNLIDTKDNKQKQGKKMQIEEKRIDEGDEVMDPRFYSSAFGKRSYLYDDFQDSDPRLFSTGFGKRSYDMDDPRLFSAAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMN4</accession>
    <name>A0A0N5BMN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000717300.1">
        <property type="protein sequence ID" value="SPAL_0000717300.1"/>
        <property type="gene ID" value="SPAL_0000717300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894540" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000717300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16338" checksum="5289482E7682DE1C" modified="2015-12-09" version="1">MTKFSIFIQLVFLILIFEGVRYSLQKPAFSSDNLILSLNGEEIQDEDVNRNLNGDRQIVIIKRSIPGILFHRLPTDEDYEDDSIRKAPLTKRAFDRVDSGYFGLGAKKRKRSFDRVDSGYFGIYKKAFDRVDSGYFGLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN84</accession>
    <name>A0A0N5BN84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN84"/>
    <dbReference type="WBParaSite" id="SPAL_0000736300.1">
        <property type="protein sequence ID" value="SPAL_0000736300.1"/>
        <property type="gene ID" value="SPAL_0000736300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894577" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000736300.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15078" checksum="F782E77B25EFC1EC" modified="2015-12-09" version="1">MKLFIISVTFLTLFVTSLEGLKCHGLVKNFGNYSKFHTDTGEVCTSLSQYCFSVNGIVDTVKNVYIAGCDELLTEPDFKNLQLKCTGNTTININTASNKYAFTCCGNDMCNSSYTSKISLGFLCIIAISFFMNFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNM3</accession>
    <name>A0A0N5BNM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BNM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000750100.1">
        <property type="protein sequence ID" value="SPAL_0000750100.1"/>
        <property type="gene ID" value="SPAL_0000750100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750100.1"/>
        </source>
    </evidence>
    <sequence length="938" mass="105641" checksum="78CC0044F102AC41" modified="2015-12-09" version="1">MFSSNFQNESIENASEMLLTCINENRIDVLKSILNQLGKQQNYLSVLDGIHNEIGTLLHNAVVLNNIDAVRTLLSVGASPCIQNEENKTPYQCVENEDIKNAFIQEILQAAATSNAGKVCRLIASGVPVNAYDSELTRNTPLHWAASFGNEEIIKAFCDSQANVNAVNNKGETPLHDAVKRNDDKIVRILMDYGADVHHKDNNDVSPFDLATSKNFSSLVSLMSMNDVAQQLRRAESIVSGDLETASIITSDTATDFLDKTNNNQVNKKLERWTDLLWPQPQFLEIDKNIDTIQFPKDNRLKVYFSSSSEGNPRRLMQCIQTVSTVLASIHLEVEYRGHEIPDSPLEGRIICGLYDLGKGNGSYSLSISKLGIEVYANDYSGIKYGFSTLAQILRLHRGNAYMFSQRQNSVDYNDERQLSNKVLSLSNTSFIPPMEANVSLNNSFTGSTENNFTFVTPPGQIPCLTIRDFPDMEIRAVFQDFSGCRILNTETVLQMATKLSYCKINYLFVNFESRTTDTYQLPYTNRDLFHMTQVCEELFITLIPSLDFQTNYIELDDARGFIENFLNDFPLCKSVHFGENITSILLSNPQFLSTIQKRIKKIFLTIEITENNINQINNLPPYTILCLDAKFPFELESKLSARVNVILRHTISDVGFLTSSPELIGKKAILAEKLTYKTYVLGNIICDLSTGVEIMPPSLSYIPEIAITGISWNKSIDFKKYLFFMPRITAEHILLDGGLTVLFEQAMTLGKVEHEITKFSLGQHKLSSVINCPLNALKPSKNVISIFVEILLNPDNIKLDRLTPLVFKKARIELRKSMKALNDARKHLPYNFELALVLAEIQLVTELMTLLSRLGQSLCMYGNSENLRGVTYLSVGQLPANIRTDMANALLEIRTKFQHTWLSRNMASTLPNALKIFDNLFKALLPPNLQNYSNMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP68</accession>
    <name>A0A0N5BP68_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP68"/>
    <dbReference type="WBParaSite" id="SPAL_0000769500.1">
        <property type="protein sequence ID" value="SPAL_0000769500.1"/>
        <property type="gene ID" value="SPAL_0000769500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000769500.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23899" checksum="5C0727D9F0FEE95D" modified="2015-12-09" version="1">MCVFKKMPNVTFIQKYEINDEIGGKINNLIKTKWLPQTDLFGDKRITGFISHGGINSFSEAAYNGIPIIAVPLFADQTRNSRAMEMIGVGKKLSKFDIKDPNIVENTIKEVFFKNKNYHINAQKMKDILKNKPYNSTEIFIKHVDFACKFGIQPQMKMLGEDHTFIESYNLDIIAFFLLSISFTLYSIRKLAKCAVRRIYKHKIKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPV6</accession>
    <name>A0A0N5BPV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPV6"/>
    <dbReference type="STRING" id="174720.A0A0N5BPV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000793100.1">
        <property type="protein sequence ID" value="SPAL_0000793100.1"/>
        <property type="gene ID" value="SPAL_0000793100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF130">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000793100.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29558" checksum="E237AACF9993786F" modified="2015-12-09" version="1">MEINGKEEEDYSPPTFNFNMLKKYFEAYNNESRLMVERCEKFAKSGEEVEIFNIVKRMALDIICDTAMGVKINAIDEPNNPYLLAVEKDKTLSILKSFTQSIIKQKALEFENNKVELNDNTFLSNLLQFKQENKWTDEDMREEVETFMFAGHDTTSSLVSFLWWALVCHQDIQEKVYEGICGVFGEKERDVLPEDLPKLNYTDMVIKETLRRYSIVPYFNRAISNEIEVCGYVIPKGANFVFPRQHTNYNTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ17</accession>
    <name>A0A0N5BQ17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SH3b domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ17"/>
    <dbReference type="WBParaSite" id="SPAL_0000799100.1">
        <property type="protein sequence ID" value="SPAL_0000799100.1"/>
        <property type="gene ID" value="SPAL_0000799100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000799100.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16564" checksum="0C3756A97A27CD81" modified="2015-12-09" version="1">MFGQKPIFKLDDREEVEKIVDFKDNEIIRSQTYLLVEQLIEAVRGKRYDEDNYEVTRCGNGDKLDVTDKPLGDLERKSLLKKLKIGDRVIIRDHTSGKWDAIYSGGNDDAYIVKSLLKNAAYVVKEKKRGRPKKVHLQDIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQK7</accession>
    <name>A0A0N5BQK7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipocalin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQK7"/>
    <dbReference type="WBParaSite" id="SPAL_0000817000.1">
        <property type="protein sequence ID" value="SPAL_0000817000.1"/>
        <property type="gene ID" value="SPAL_0000817000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000817000.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13486" checksum="665D99758540782E" modified="2015-12-09" version="1">MYYGFSVFIEGNVTWNVSEINNVTARFKFYDETPRRDYKVLQNGRNFTMSKYVGGKPSEKDDLELRIDYNKSGTEANLRKKLKELCPNSENCIYKRKEYDSSDCMCYFKTIHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRN3</accession>
    <name>A0A0N5BRN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RT_RNaseH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRN3"/>
    <dbReference type="STRING" id="174720.A0A0N5BRN3"/>
    <dbReference type="WBParaSite" id="SPAL_0000852900.1">
        <property type="protein sequence ID" value="SPAL_0000852900.1"/>
        <property type="gene ID" value="SPAL_0000852900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000852900.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14357" checksum="FA981A7378339B9C" modified="2015-12-09" version="1">MDAIKVFFYYNGSLCKYPRIVSCASRILQKVEKRWQVVEKKALALAYAVKQFKYYIESKTTNVFIDQRAVLAIKSPKENQSKLRRYQMALATYNLNIYYKEGKANVLADMFSRNPEPKQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRP1</accession>
    <name>A0A0N5BRP1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRP1"/>
    <dbReference type="WBParaSite" id="SPAL_0000853600.1">
        <property type="protein sequence ID" value="SPAL_0000853600.1"/>
        <property type="gene ID" value="SPAL_0000853600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000853600.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25584" checksum="A6F6A55CD3663F01" modified="2015-12-09" version="1">MDFLSLPDNFQLQVFRELDWKSLVNLRLVCRDFYFTIEKNIEQLDRPKVDKLEVICNREKVEYFRYSFKKLYLPNAVSRWKNYSLENEEQYKSFLKERDFTEIKKLKFLKYWAPESNEVLINMPRGTESYDYVVNDYVEMVEINADKILEVISDEILVISPDEFEFDGYFFKISRNAEVLSDDIGNNNFEMVSFTIEASSNPDWERLTMIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS22</accession>
    <name>A0A0N5BS22_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS22"/>
    <dbReference type="WBParaSite" id="SPAL_0000866800.1">
        <property type="protein sequence ID" value="SPAL_0000866800.1"/>
        <property type="gene ID" value="SPAL_0000866800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="245"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000866800.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="54664" checksum="DDA7405D4C75944B" modified="2015-12-09" version="1">MNCLFDANVTSKSLLKYVNQMRKPCDDFYDYTCGTWLESVRKQSDVDKRGCLVENAHDFEEFKKKALRGDFDSKYPALQKINRMTEKCEVYTDSVRNDCMKKVKHFGFYAFLSVYMKKLTESFDYDHLYDMFEKIFEANKYEMENLVNEKQSYLTEGAKRKFIKRLSLLKFYRGHIERLRDTKFMEKCYSYFEYSPNTTINDMLKDIDSYSCVVPHDDKNMDICVDYVSKHLSGIVSLEDLVYKNAYYSYHSNRFMINPVIVRHPCFDCRFPKSLQYGCMGFLIGQELVTRVDERLRTYDFENLRIENHNDTSQYEWEYMKKKKCFEDEYAHDIKNNKMVIQNYTCLMNKVVADSGGLKVVYRAYKRYLQESNNDDKFLIPGFERLTFEQLFFMNYARTYCNDPMDKRKSGIIKDMDGFTGRVRLTMTLRNFEPFIRTFNCTHGTTYNKTTPLCKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS95</accession>
    <name>A0A0N5BS95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS95"/>
    <dbReference type="STRING" id="174720.A0A0N5BS95"/>
    <dbReference type="WBParaSite" id="SPAL_0000873950.1">
        <property type="protein sequence ID" value="SPAL_0000873950.1"/>
        <property type="gene ID" value="SPAL_0000873950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026112">
        <property type="entry name" value="AMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000873950.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12309" checksum="13718A0F2A8FE811" modified="2015-12-09" version="1">MFELVIERNSNLDDEYMKEICSFVKCEEDHEMDCWNPINVEGHCCKLCGQSIEFEIDKTNSVNQFMYIFGYTSDEYFVIRYKNGNVKITGTQDETKCLLSKEEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSX6</accession>
    <name>A0A0N5BSX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSX6"/>
    <dbReference type="STRING" id="174720.A0A0N5BSX6"/>
    <dbReference type="WBParaSite" id="SPAL_0000896700.1">
        <property type="protein sequence ID" value="SPAL_0000896700.1"/>
        <property type="gene ID" value="SPAL_0000896700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019322">
        <property type="entry name" value="TIMM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10171">
        <property type="entry name" value="Tim29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000896700.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21097" checksum="14D033DFCAF3ACCB" modified="2015-12-09" version="1">MATPAATVVAETIPKLPLMKRIGKRVTEYLIQLKNDYKGSLEDAIADSKAKPHKALALVSFSSFAVYAFVTNPSVRDFRNTMAQKRIKMAMIPPSIHNPVTVNAINEREQLWIQNRLRFIDCFLFTLVVRTTYDSTLRSSESQDSNLRDWYFNEIFKNIVDIGAFNRFFYLEKAMEDCDINDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTD1</accession>
    <name>A0A0N5BTD1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTD1"/>
    <dbReference type="WBParaSite" id="SPAL_0000911550.1">
        <property type="protein sequence ID" value="SPAL_0000911550.1"/>
        <property type="gene ID" value="SPAL_0000911550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000911550.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7911" checksum="818AB4E22AC02A83" modified="2015-12-09" version="1">MCHPLISWKSINIDHYFLERATTLSLSLLSFSSILYYIKGWLRLDGERNSLTCFKLLSLVHQNEKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU55</accession>
    <name>A0A0N5BU55_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BU55"/>
    <dbReference type="WBParaSite" id="SPAL_0000937800.1">
        <property type="protein sequence ID" value="SPAL_0000937800.1"/>
        <property type="gene ID" value="SPAL_0000937800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000937800.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22789" checksum="D4EA89FE37692511" modified="2015-12-09" version="1">XVPHRFIKYTVPFNLKHIVDNEIDKLIEMGIIIPMETPYLHNLILVRKSNDEYRPCLDMRPTNAVAVVDSYPVGNMHEILSDLYGNTLFSSLDIRQAYYQISIPKINQVRFGLYTDRGTYVYTRLPFGYVNSGQIFQRYLDRVLGSSHLRCFARAYYDDIIIKTHSGLDDHLIKVGEVMEALSSRKLSLNIQKCQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUT5</accession>
    <name>A0A0N5BUT5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUT5"/>
    <dbReference type="STRING" id="174720.A0A0N5BUT5"/>
    <dbReference type="WBParaSite" id="SPAL_0000960300.1">
        <property type="protein sequence ID" value="SPAL_0000960300.1"/>
        <property type="gene ID" value="SPAL_0000960300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="273"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000960300.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="57245" checksum="7F4F89BE8DE28406" modified="2015-12-09" version="1">MVPLQEMNYRFEYIKGKDNIIPDDLSRLDQEEILKDSSNLNKSQSDDEEKELLSLQKMRFDELWKREKKLEDEKCKMVNCLKVLTGEIEEIDDSSDEEDDEPSNKEQPLNKIDDDIPLLQKLYFGSEENFDKITMEEQLSDPFIKEAFEEKTYDKRKIIELNNQIMIEDLTGMGYVIMVPNSKIGTVLNIAHNLSGHYNAEKIFRWLKDVCFWKNMFMDIQLHVKRCKECMLGNDIHSKNYNQKSVIFSRPMQSISIDVCGPMNVISHTGNRYVLGIIDNFSRSRHGIPEEIHNDNAKSLVNNKLTSLYQMLNIKQTTGTPYYKKANVLIERAFRQLHNICTKLITKETAQDWDELLLPMTYFHNTMMHDTLKCTPYEIFYGRSCRTPITHVDRWELTKNALKAYKHVEDTIVECRDKENKKQGGKDFPSFEKGEEVCIRRPPNKDEKIIPHKFQSPFIGGYKVFEDLGSKLKVHKGTRGRCLIVHKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW05</accession>
    <name>A0A0N5BW05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW05"/>
    <dbReference type="STRING" id="174720.A0A0N5BW05"/>
    <dbReference type="WBParaSite" id="SPAL_0001001100.1">
        <property type="protein sequence ID" value="SPAL_0001001100.1"/>
        <property type="gene ID" value="SPAL_0001001100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001001100.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33929" checksum="839FC534332D25BF" modified="2015-12-09" version="1">MSENDAISSTSVASKSVAKTECNINNTSEIHNTPHINTTPKIEEPSSQGGDNKSIDKNQVCRDYLHNICNRGKNCKFSHPPKHEDKKDIENYNFCIDFQNNGCKRENCRFIHAPQYDVEAYRATGEVTIDLARAIAAVTKDDTINGVPICKEYQIRKCTRGPRCRFWHVNIKHEKLMREQYFKDQKFGRGFFNSQGHYMVPPMRGIRRPAPPSSSTYPDPIEFKRMHYDPQVGEYHHPNYGLVQNLERKLHEAHSEIVKLHEDLKRERDRYNNLLALFHRQGNTGWPQTPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW42</accession>
    <name>A0A0N5BW42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DZF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW42"/>
    <dbReference type="STRING" id="174720.A0A0N5BW42"/>
    <dbReference type="WBParaSite" id="SPAL_0001004600.1">
        <property type="protein sequence ID" value="SPAL_0001004600.1"/>
        <property type="gene ID" value="SPAL_0001004600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZF" evidence="2">
        <location>
            <begin position="356"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001004600.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="82691" checksum="5A486BD193AE92B6" modified="2015-12-09" version="1">MNHFPNRKSNNYQLNNAVVSSSRFPSNYPDNSLNNPNCMGSNNYSPIVYQQPNVYTPYAFNNCTSEFNNGYFQTSMSGIMPDSKSKYLSTIIHPSGGKSKSVMNTQRHLHMTGGNKKSRFFQANTNKVKGAQFHCDLCKVPCSDQKALDDHIKGKNHRRREALVNKNNDDSIKQGSVYKCEVCEVLCSSKDALISHVKGKAHEKQITNLKRLKLPIPQVNYNSVTSTKGPCYDPGVNEEKLDDSEESATKQVVGEEYIEEINCNITGKFIEYSCKLCECRFSDVNAKNIHLSGKRHHSSFRQKVNPSFNSEVIKKDEKKSSGKKVRAKNVKRNKQNDSRSSFLPKDILNHDPLYVMSFSLPVLYSLTLEDEKIYERCKQLSFSQNEMTKIDEMFTEVEKALANLSSVETDRCVGSVLKIKCIERVGILPCGIAINIDKEFDLNLVLTDYPTCKDFDYIVSNLPGELDKVSCSKWKIIPKMSESSILINSMDSVYSINLCITSPACRDSNISPSQAPEVLTFDSTNNILRKVRHFNWFEHYYGSDKDVKSTIQILRQISYKIPSWKVFNDDVYLMLLLFHTSISSLVEKLYPSGLLRRFFEMLASGLVVPKSFTIIDPCERDETNILKNLSQQVREDITNCAQHALRMMSFNKLPDIIFLEKKVEVNTNISGNCPGEVLDGNGTKYLTPYGNNEKAYCSEENTCANSVPLRKRKGDESITYPDVRRLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWN9</accession>
    <name>A0A0N5BWN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWN9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWN9"/>
    <dbReference type="WBParaSite" id="SPAL_0001023000.1">
        <property type="protein sequence ID" value="SPAL_0001023000.1"/>
        <property type="gene ID" value="SPAL_0001023000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001023000.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12092" checksum="3C900199B1ABD309" modified="2015-12-09" version="1">MSTSNEKLVWDWPLNHTEDGVFTSKEIDGKIGITVDCKIFKDKEVNVIVDKDKIDIHCLHEEVEKSGLVCKREISRCYRLPPSLDPKTVKHSLKNGELTITVEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWT2</accession>
    <name>A0A0N5BWT2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWT2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWT2"/>
    <dbReference type="WBParaSite" id="SPAL_0001027200.1">
        <property type="protein sequence ID" value="SPAL_0001027200.1"/>
        <property type="gene ID" value="SPAL_0001027200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="1">
        <location>
            <begin position="327"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001027200.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="85726" checksum="B3A5CA336017A654" modified="2015-12-09" version="1">MLKCVLELADKDLKPQIKAESLSIINGILGNVSSVLQRQIMRKILFSMGLENILPSLSIYKCTRLNEELKIFENGQRYEESIQLSKSGKHPLNIFSEAYMKLSMNKECITIFMEIIEKIASSSEVTKNDILKLYFTLNKEFKKEELSKENLMTDLLNNNTVCDKWAFDNESTAKSPKILGQNSYTFNDFNYEVSISSDLPNTEKENLGRKTIDVEVQTEGFQELSSNLLTVVDENKKLKIVMNKTKPPKAPPLPNFQKNISLTKEIPSLSVPKEKVVVNLESKKLLPPPPPPPLLLKCNGKNFQSTSKCTIKSSDLLNVENKLPLNVPPKYNKVKSTNVVSWTPIKINNLESGKTIWNQFVEPEFSESERNKLELVFEKPQKIPRRLTVAAFGKKPKDCLSPNKNNNRLLSKGLSEKRVLNLGIVLSRFKLKGVNLVEALDSERCSTFDIDLLSNLLLQYPTEEEKKYFQNIDETNTLNSIEAFIWAVSRKPHLKIKLELMVFEANFRVDSKNYIQKAEQCLDVCKKVYQNSDIQKFFYKCLQIGNFLNQGNYNGNAYGFTLTSFINILTFKGTVTNKSSSIRIVDLLVESKAFNTEEIKNFCDELEKVKSFDLNDFEIMSNKINQQLNAIKSKVESTESFMTTEEITFVFTNNINICSKLKQLVSDIKSLESDLQKYYCAEKMKIEEIISILLQAFNLLKKANLDYESNKIHSENHHKTQQSLGKSLSKLKEKIVKCDNRKNFVDLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX61</accession>
    <name>A0A0N5BX61_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX61"/>
    <dbReference type="STRING" id="174720.A0A0N5BX61"/>
    <dbReference type="WBParaSite" id="SPAL_0001039600.1">
        <property type="protein sequence ID" value="SPAL_0001039600.1"/>
        <property type="gene ID" value="SPAL_0001039600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001039600.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41648" checksum="BB4F39B4473C1E90" modified="2015-12-09" version="1">MDSFTSKILKTCNFGIGPISCHAWNADRTQLAVSASSVIYIFSIEVKKNQNTIDFSLLHTLLEHDLAITGLDWAPKTNRIVSCSQDKNAFVWTFDKNSNVWKPELVLVRINRAATCIKWAPLENKFAVGSGAKVVSICYYEKENDWWVSKQLKKPIRSTVNCITWHPNNCLIGVGACDFKSRIFSAYIKEVDEKPSPISWGNKMPFGQLMAEYSVSSWILDIAFSPCGSRIAWVAHNSTLSVVDSEVDVTKINSLKLKTLPLCSIEWIRENKLIGAGYDYVPMIFKVTDDGIPSYQGKADDSSASGKSQESEGVFNAFQKFQNIDRKGTEVVDVKTASAHQNAIRQIAPFSGRCGNYTEYTTCGTDGLVCLWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXB8</accession>
    <name>A0A0N5BXB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LSDAT_euk domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BXB8"/>
    <dbReference type="WBParaSite" id="SPAL_0001045000.2">
        <property type="protein sequence ID" value="SPAL_0001045000.2"/>
        <property type="gene ID" value="SPAL_0001045000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF44">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1278"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="180"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="503"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="645"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="881"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="933"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001045000.2"/>
        </source>
    </evidence>
    <sequence length="1565" mass="179925" checksum="B700B370E36FF691" modified="2015-12-09" version="1">MDPTNVVHNSPISYHHDTKNKEKRKKFHKNRHSHGANAPPSNVSIHHWKDMLNMSVLTSTYNDEDSKNSDDTEDIELGDDIGKIFKKRECSNYVRSMRESQRCGCGRLENEHSLAAIVNKRVPLSDTEGENKHDNKEEEWIKKDITKSTGRWSIKNDTTLIPTDAYGTIEFQGGPRPIKAQYVRLSFDTECSSIIHLLQNIWQIPPPKLIISIHGGTGNFNLQSKLSRIFRNGLVKAASTTGAWIITSGAENSLTRQVGAAIESAQNSIRNKTKIISIGIASWGLLKRREDFIGKNHTVFYRKMGNNAKSRFITLNNRHSYFLFTDNGTVGKAGSEVVLRRRLEMYINEKQTIVSGGRTVPVVCVMIEGGVYSIKTALQYVTSIPRTPVVVCDGTGRASDLISFAHQYIQDDNTLPDGLRIQLLSLIESVFQLTKDEAEHLMNDILSCVSQKRMLTIFRSTGENRKDLDHAILTALLKGYNLTSSEQLSLALAWNRVDIARSEIFVHGVEWNTNDFHSIMMEALVSNRVDFVRLLLENGFDMQSFLTIGRLEDLYNTDKGPTNTLYYIVRDVTKIKSGYRYKLPHIGLAMEKLIGNGFKSYYTSEEFSKKYNKYKNTQKIYNNKKKATDSLASVIFPFAMMKKNDSSNNINSTQWKNTIKSTITQNFQSKVKSVFINVDDNEVEKISQKNSSTNLSNLNHSIEDSPNFRYPFSELLIWAVLTKRHEMARFMWEHGEESMAKALVACCLNKNLAKEAREDYLDIEISDDLKRNADEFKQLSLDLLDCCYRQDDDKTLQLLTYELKYWGHETNLSLAVVANNKQFIAHPCCQMLLADLWHGGMRIRSNSNLKVIIGIIFFPTIFTLEYKSKEELMLQPQTAAEHENDLYDTSSSEEESSDSDSESSSSSESEDDHEIIKNKSFFGSSQSLHFPSIFPNKLRRSRKDTNRNRRQSITSITSNSKNTNLNKMKILNDSETSVDKLNKQKESSRRRMSSTCKEILDPTKLSYKEVQERRGSVQRNRTNTISSSYKKINSIETTAKPTIPLKSKQIKAKRKVYEFFFAPITTFWTWFLSFFIFMMANTYVLLVKTPLHPTILEWILFVYVLSYGLEELRKLFMSEPTRIRKKLTFFFSNTWNWLSSLAVVGFIIGFIVRSVSSSSLATGRVILAVDYSIWCLKLLDYLTVHPTLGPYITMVGKMTNAMKYHITLLFISLLSFGTVRQSILFNDENWSWVLLRNVFYKPYFMLYGEVYAGEIDLCTDTGEECVPGSFIPPLMMTVFLLIANLLLISMLMATFNHIFDEVNSFAKNYWLFQRYHQVMKYESSPVLPPPFTLIYHVYWVGKYMYHRNTFNICKLLKKLNIITDKTVRNAHFFDCSLKLFLTLSQVEKLHDFEEESMESLTLQQEHIKKTAVDSKIRNTSDNTDTILSRVTDITRSELSLKETVTMIEKRLLTVETNQVKLLDRLENIVDNLPNILPEYKRKEVTRMDTDSSSIPNDGISSRCDTHFVEGSTNENKRIGCRIGYTSITDTIDVENYMKTKEEETDVPDIYTEDDKYELDYEGYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXB9</accession>
    <name>A0A0N5BXB9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXB9"/>
    <dbReference type="WBParaSite" id="SPAL_0001045100.1">
        <property type="protein sequence ID" value="SPAL_0001045100.1"/>
        <property type="gene ID" value="SPAL_0001045100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001045100.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45549" checksum="6334BFAFF92CCCF5" modified="2015-12-09" version="1">MDLENLFKKLRSSLSMRKNVPLSQLIRECNSDWNIDVYTIYSEISSKHKSDLKDIASWLGSIESVIIKNTNNDDYIVNFKFGDEHADLRRYISVSKPKKKRTNKRHASNLLKGFKSWKDSGTSNCRSRTRQYSTSLNNCFRQRINTKNHEEKNYITTKSTNFVSTVSNAGKLHLNNAILNATFTNRRLENQRSPIKLENEIIEKFSNVSLDTTNRTTDNSLAETKVSKEINTYQTEDLFVKKDYKESSEKSYGEKISKSNKKYVPEYIFGQDAIKAMLKDRKTIVATNKNELKNNQDKEKIMDDVKKNDEAQQFPSMEVRKPFAVLQSSNQEYSHLYETSIPNEREVKDLNSKTYYDDNKKKERFKFHSERKIERKTKFSYSFPKPSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYL7</accession>
    <name>A0A0N5BYL7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BYL7"/>
    <dbReference type="WBParaSite" id="SPAL_0001086900.1">
        <property type="protein sequence ID" value="SPAL_0001086900.1"/>
        <property type="gene ID" value="SPAL_0001086900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001086900.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38099" checksum="2EA6C83B8625C52D" modified="2015-12-09" version="1">MYLRRCGPRKISSWPECQYPRQRFHADHFYICNTARGNRVGRRCEHSAGVIHETLHALGLYHEHCRFDRDIYLQIRHQNMDEGGIRNCLKVNYRDSNTYFLNFDYGSIMHYGSYSYSINNRKTFVTIDPNYKRTIGQSQRLSFIDIKTLNYHYCSDVCSHKIPCTNQGYFDSKNCARCKCPEGFGGTHCEEIARQRRGCRKPLIMVTYRTLKLDLRNRKKCVFHLKTMPGRKIVINIVSLNMFPYEDEQCLFDNSLEINYQLDKSVTGALFCSNDGNKLIISFNEHVIIYYRSEHIENYVNLLIKSIDYRQTKLPTRRLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYX8</accession>
    <name>A0A0N5BYX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRR containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYX8"/>
    <dbReference type="WBParaSite" id="SPAL_0001097700.1">
        <property type="protein sequence ID" value="SPAL_0001097700.1"/>
        <property type="gene ID" value="SPAL_0001097700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001097700.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16869" checksum="6D237F9E9DD89C3E" modified="2015-12-09" version="1">MMPRNVEVLELIRVHDIDNVMPKTIIKYMPNIKLLMIECLSYKERNSLDNFSKLECLTSCNYCPIRIPRTLKLLAFVFVYGHWAVKSDDLVFTDNVIKSHYEKFTKRISDNSDARDRYILFNDIHYWHLYKCAIQKYFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZE0</accession>
    <name>A0A0N5BZE0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZE0"/>
    <dbReference type="WBParaSite" id="SPAL_0001113100.1">
        <property type="protein sequence ID" value="SPAL_0001113100.1"/>
        <property type="gene ID" value="SPAL_0001113100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="233"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001113100.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45962" checksum="3C7FDFB1A7DEBF52" modified="2015-12-09" version="1">MTVVNILRSRFGAEKIGLCTFHFMKTIFKVFRNTGIMETFIKEKRAESEYSLSIGNIFSIYVLPYNRIHEKAGPIIDKIISFEDNIDIRIKWLEFKNYFLNNWSNIETAKMLSKYEQHTITTNDIEIYHASLSRYVKMGPSLGLRRYTEALLHLQLDTEIGIKQLEIERFKITSKEKEMENYRSNDLKYAPRLLQRIKMNDKNEAFDDYVKSRDSNRFLSAITKIRAVKKVKIEYGSCDDGSNDNENVHKQWFTDMNIENIILNEIGITFSGERSYLLNVHISTILGYESLYKIENKKLIDDGLKLIFENGLCKYENVFMPMNTAGVYKRGSHWILGHLSRSKNCFFIYDSLNSTSEDVAERIVSRIRNAHHINLSHSVSRNIPQQNNGYDCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZU5</accession>
    <name>A0A0N5BZU5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">APS kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZU5"/>
    <dbReference type="STRING" id="174720.A0A0N5BZU5"/>
    <dbReference type="WBParaSite" id="SPAL_0001128400.1">
        <property type="protein sequence ID" value="SPAL_0001128400.1"/>
        <property type="gene ID" value="SPAL_0001128400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="11">
        <location>
            <begin position="216"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="10">
        <location>
            <begin position="394"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001128400.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71019" checksum="5EF940C1328FD9F8" modified="2015-12-09" version="1">MSTNVTQQFHKITRDERARNLGRYPQFRGCTLWFTGLPAAGKTTISMRLEQLLSRVGIPSYVLDGDNMRQGLCSNLGFTLEERKENVRRVAETAKLFADCGIITLVSLISPTAAEREEARKKHEEAGLMFFEIFVNTPLNVCEKRDPKNLYKKARAGLIKGFTGIDDVYEVPTNPKLVLDAAGNTEHGCVERCFGLLYDHGLIPEDCALEYYEHGIKELFGNPQQIETYQKQIESFPSVDLTLDDLQWMQVLAEGWASPLNGFMRERQYLQCLHFGQIYDSYAKFDDNGSERYRPESNRSSSQSIPIVLAVNEQKCIEIGTNTQVGLKYKGKYLGVLENIEIYAHRKEERICRIYGYNDNRHPGISKIRQQGNWCIGGDLIVFERINYNDGLDDYRHTPRELREIFYNANCDAIFAFQIRNPIHNGHALLMRQTREQLLAQGYKNPMLLLHPIGGWTKDDDVPLNVRIKQHLAVLEEGILDPRWTVISIFPSPMLYAGPTEVQWHCKARIAAGVDCYIVGRDPAGIQNPDTGDFLYDPTHGSKILSMTPGLRGIQILPFRVAAYDKRLGQMDFYDDSRRDDFLFISGTLMRQIARNGQSPPQGFMGQKAWSVLAEYYQSLGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0M7</accession>
    <name>A0A0N5C0M7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-type protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0M7"/>
    <dbReference type="STRING" id="174720.A0A0N5C0M7"/>
    <dbReference type="WBParaSite" id="SPAL_0001155500.1">
        <property type="protein sequence ID" value="SPAL_0001155500.1"/>
        <property type="gene ID" value="SPAL_0001155500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004686">
        <property type="term" value="F:elongation factor-2 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16967">
        <property type="entry name" value="Alpha_kinase_eEF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.200.10:FF:000002">
        <property type="entry name" value="Eukaryotic elongation factor 2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047588">
        <property type="entry name" value="eEF2K_a_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="78"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001155500.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="80767" checksum="AC79190279BABA5F" modified="2015-12-09" version="1">MTSIAKEDMLHSEDDEVNSTIVGNSQKDLDDSSSSEKRQKYIKLWKTIARKAVDLSLKDPWAKYKIENAKTQKCIRYMYNALTKTWKRDEVYVKKQDKSFARGAMRECFRVKKMDKLCDETNWKLAMNYVCKRYIQEVDRSVLFEDVKLQMDSKLWAEEFNRHNPPKKIDIFRVSILEFVEEEGSPLYHLEHFIEGEYIKHNSNSGFVSDVVRMTPHAFSHFTFERSGHQLIIVDIQGVDDLYTDPQIHTVSGTEYGSGNLGTKGMALFFYSHQCNDICRSMKLTEFDLSRNEIENRINKYGSYISNPSTKFSIKAQLSLDPCESIVSFKEDAMERLRLRTISFNSIASHESFRSNDHSEKCACDNCSDVGGVNFTLDDLHETFTDKDSVCGESINDSENNEIVPSVGAMRRRRYYSGHSDTKSSQGERFQSAMRKFSKPAGFLLYNNSSDSILNSLKNSNSLFVLGQVHLDLARYYCIGRFNNNKKINNNTKSWDSCVRNEFRDDKIIYDKESAIFHLDIARKCGVLEAIKTIAEMAYDLPHDLMKDVDSSDLEKCGIFDCGGKIAFGFQMMELAAEMSDRNAIHFIASSYETGQNLPNNKQADWSKAMYWYEKALEYYALEEYDNNDYTRTKQDLTFVCPQYEILAKMAQMCNEGGFGLERNSLEAYNFYNEAAEVATEAMKGKLANKYYELAEMCDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0S1</accession>
    <name>A0A0N5C0S1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0S1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0S1"/>
    <dbReference type="WBParaSite" id="SPAL_0001159900.1">
        <property type="protein sequence ID" value="SPAL_0001159900.1"/>
        <property type="gene ID" value="SPAL_0001159900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="369"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001159900.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="72317" checksum="D343D209EA2D756D" modified="2015-12-09" version="1">MSKEIIESTKWEKGKPIPYLALAKTMEDIEDTSSRLDIIKKLATFFVTAIEFSPEDLPASVYLCSNQLGPVYEGLELGIAEGSLIKAVAESTGRTVAQIKNDLQVKGDLGIIAQESRSSQQVLFKPKPLTVAVVFDKLRKIGKSTGQSAMKQKIDLIKGLLVACRDSEARYIVRCLSGKLRIGLAEGSILVALSNAFTMYRLKCENKKVDDEKLKEIMAGDTLILRTAYCECPNFDRIIKYALEGGVNCLPEKCKLTPGIPLKPMLAHPTKGIQEVMKRFGKAEFACEWKYDGERCQIHKTKDGVKIFSRNQEDNTSKYPDIIASLPQCFSDNVVDFISDGEVVAWDVSSKNILPFQTLSTRKRKNAGDSEIKVTVCVFFFDLLYFNGEPLVRKTFRERRQILRDNFKEVPGVFSFATSMDTTDTDEIQKFLDEAVKGKCEGLMVKTLDEHATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGGYHGAGKRTGFYGGYLLACYDYDMEEYQTICKLGTGFKDDDLKVQYEYLNKLVIEKPRASYKYDSALEPDVWFDAEIVWEIKCADLSISPLHQAGRGLVDPDKGISLRFPRYLRHREDKTCDQATSAQQVAEMYEAQENVKNSDSTSYVPMEEEEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C139</accession>
    <name>A0A0N5C139_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C139"/>
    <dbReference type="WBParaSite" id="SPAL_0001171800.1">
        <property type="protein sequence ID" value="SPAL_0001171800.1"/>
        <property type="gene ID" value="SPAL_0001171800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001171800.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33834" checksum="CD049149253D2C46" modified="2015-12-09" version="1">MAGGMAIKVILKPILGLMDTRDAHSSELEIEKTLTLNPRTLVKDLCKSVMEGYNSGHVNDDFRVLACHSNFEFCPFRTFFHDTNAPIGSVAVLFEGMLTIKILIPLNLFYDCDCNPNTMTPDVVYEEFIKYMISRLGNNNSQVPDPIIQYVKNEMEGRSFKQLPSETLSIMDRELTHARQWNITSMSRSASQSPKRSISFASDPRDSSTSSGGVGSDVFQECIAVLDSIIDGVSGTTSSQKSHKEIQQGGRAKEGVIYDKEIELPMHELLYSRSHAHDFGRYACELNVLSGRTGSDKLTAGNICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C163</accession>
    <name>A0A0N5C163_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C163"/>
    <dbReference type="STRING" id="174720.A0A0N5C163"/>
    <dbReference type="WBParaSite" id="SPAL_0001174100.1">
        <property type="protein sequence ID" value="SPAL_0001174100.1"/>
        <property type="gene ID" value="SPAL_0001174100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895185" evidence="2">
        <location>
            <begin position="25"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001174100.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="74265" checksum="4B5722B17A80D97D" modified="2015-12-09" version="1">MHIFYNSNYITIIILSILFYQYQAIETNVKSDDSESLNLLQNDLISKSDIKQDSMVSSLTENGELNYFQKRQANLKSRQKKSKKTNSRTTSRLKITTKKKPLSGKISPRKTTPRKTTPRKATPRKSTPRKTTPRKAKPVKTTSRRTTTRKTSFKKTTKNPAILKTTRKMSSSNKSTTKKPTTTTKKRQISKVTKPSPIKPIIVQSTTRTPTTTTSVTTTEKPDDLSKYIKKTIDDINKLREKFNRKPLIVKDELVKEAKNYSDYFVNDVEDLEEYKDEGRLQYLCSIKDLDKFDAVKFWASNYDDKIIDKSEEKFEFPEFAQIIAKKSTDIGCAIKKAELFVGLFCRIQPTVDLGHEDYVEDENSKKTTSRLKITTKKKPLSGKISPRKTTPRKTTPRKATPRKSTPRKTTPRKAKPVKTTSRRTTTRKTSFKKTTKNPAILKTTRKMSSSNKSTTKKPTTTTKKRQISKVTKPSPIKPIIVQSTTRTPTTTTSVTTTEKPDDLSKYIKKTIDDINKLREKFNRKPLIVKDELVKEAKNYSDYFVNDVEDLEEYKDEGRLQYLCSIKDLDKFDAVKFWASNYDDKIIDKSEEKFEFPEFAQIIAKKSTDIGCAIKKAELFVGLFCRIQPTVDLGHEDYVEDENSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C181</accession>
    <name>A0A0N5C181_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BH4_AAA_HYDROXYL_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C181"/>
    <dbReference type="STRING" id="174720.A0A0N5C181"/>
    <dbReference type="WBParaSite" id="SPAL_0001175900.1">
        <property type="protein sequence ID" value="SPAL_0001175900.1"/>
        <property type="gene ID" value="SPAL_0001175900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046189">
        <property type="term" value="P:phenol-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="10">
        <location>
            <begin position="158"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001175900.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="59797" checksum="32949CA532BE527A" modified="2015-12-09" version="1">MASGMKFHYYKQKSVVSSSDSSEINPEDRLNSYKMRFRRSGSIGMPFVPEENIKTVKKEISLDGCHEEGLQLLTLIIKSQRNSNTLSNLISSIPSDVTIKHVETRDPRSGNQSEIEVFLELEWEDATTTSDIINDLRNKNLDVEEVSSTVNPKGSSVIEDPGSEDALSGSQWFPKTINDLDICSKRVIMYGAGLDADHPGFKDKEYRERRMMFAEIALNYKQGEPIPRINYTEAEIKTWGVIYRKLRELHKKYACKEFLDNFELLERHCGYSEKNIPQLEDINKFLKSKTGFKIRPVAGYLSARDFLAGLAFRVFNCTQYVRHHADPFYTPEPDTVHELMGHMALFADPNFAQFSQEIGLASLGASEKDLANLATLYFFSIEFGMCGCYSSDPEDSENFVENEENNLNKNRNLKVYGAGLLSSAGELSHAVSDKANILRFDPDRVVKQECMITCFQTAYFYTKNFDEAQQKLRMFTNNMNRPFIVRYNAYTESIEVLNNNRSLALAINQLRSDINLLASALHSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C255</accession>
    <name>A0A0N5C255_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C255"/>
    <dbReference type="STRING" id="174720.A0A0N5C255"/>
    <dbReference type="WBParaSite" id="SPAL_0001206800.1">
        <property type="protein sequence ID" value="SPAL_0001206800.1"/>
        <property type="gene ID" value="SPAL_0001206800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895220" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="551"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="846"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001206800.1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="134157" checksum="263B52EA1D65D2F9" modified="2015-12-09" version="1">MSRCNIIFVKILINFFLYIQLRNTTNRHLYVQSLNSSNYEFPKIINITTNTDLIILKCPGSDYGNEEGGSFSINPDEEYKLLSSKTQEFVWIYHLNGLSYKKEEEISCGKLKLNNTQNEVNWTYKLTWLLNSTISIKQLNITFKKYIKNECGNTGNYTILIKNRNENIIQMSNNSLNSVYKDDLIYVFNQNTSINDYVISEPCVIYAPYHILPNIEIRSLKNQDVISKNEKFVIIKKEFKEEKFDINLVVPDPKENKNFYSYEKVNITKLQFNEDGSLNEIGNKKLFNRSITVEGYTLLRIEYNCDYCINENGRNVSFQNFYFGPMKKNHVEELPEIINNDSKSLIKPNCSTDKISFGFLHTIKFGQLEIKLADLKNIYNNKKYNFELSKNSVTFTNETYNGVLQCMYYTPDNGIYILQTTFKDYKNSNFNHTNNQRKIIIVVITISIIIFLVTVIIITIILINKKKIKIYINKKKQRKIHSNIYKYWKKIQSLDFKEYANILKKEQYIPEDVVDRIAKIAISGGQLTKDLSDCTNNDTLVKSQLVHPKKISANYVTSVSPSRKYILSEPPIKNMIPQFWEMIYEEKVRVIIAFGYNKHENYLESFEVYWPSKECTYGNINIINYSEKETLTANSIVLNFYISKNDNIKVPVTIFYVNNWKENTIPENFQELVKLYEEVSYIAETSTVLVHSGNLNGSRTFLFAFFAGIVESFTNNKDFNEPMEVIKMIRNQKYGGFISTNEFVFLIFSIIQYFVDKKYLLESEDFSKYMEKFNTFIHGKYDFTTKNAIRYKNPLKFFVSLDFNNLNCLVNMTDKAGRLNEDEIKEKCKRTIKLNSYEKKYIKGSQREMSRNRYPEINCLDEHAVDYNISTNLNNPFDTIAMSNDMIYTNGKNIKRRLIMMQAPMENMFNAYIDLLYKNNVAVIIAINNCEGKKDNEKFDRYWPINSEKMTYGNYVLGQTDKYVDFEKGIDVSYYFIYNSDNRSLPEVTFMLLRFKDWPDKKSIPSDHTILCDMKLYGLDEANDRPLVIHCNNGIGKTGTVAYALYMMDNLSEDREFNPIQDLIILRQHRLDAVQTRQQFLIALLAVAHYCFPDIYLYDKNAFNNIKKLFTDIIETEDKIDERIVSNLRCNGKSYLSFEKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C289</accession>
    <name>A0A0N5C289_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C289"/>
    <dbReference type="WBParaSite" id="SPAL_0001210100.1">
        <property type="protein sequence ID" value="SPAL_0001210100.1"/>
        <property type="gene ID" value="SPAL_0001210100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210100.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21483" checksum="206B82C4C9D4305E" modified="2015-12-09" version="1">MKKKSDSIERLRKLRSKKGIAKKIGKSKAMESKKEGNKRVAETYSIGKLKKTVCSNAFQLILKGHPGVINSIEDQNLKNLIKSVREDSSPEYFQSINNFLDTELRVLELKNGGETSEIFTPNGSNNNPNMITTQESTTSVTNRNSNMASIPKESPTSVIDQGVSNNGNEQLLMASGSNIIIKNSGAVIFLHKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2K4</accession>
    <name>A0A0N5C2K4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2K4"/>
    <dbReference type="WBParaSite" id="SPAL_0001221400.1">
        <property type="protein sequence ID" value="SPAL_0001221400.1"/>
        <property type="gene ID" value="SPAL_0001221400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001221400.1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7687" checksum="4A1718FA23D35E4D" modified="2015-12-09" version="1">KKVRHTWPPWRNRLARSAVNRKVGGSRNDVIYIFDYLIITLFGVSFIPYIYTIHYIVNEFVLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2N3</accession>
    <name>A0A0N5C2N3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C2N3"/>
    <dbReference type="WBParaSite" id="SPAL_0001224300.1">
        <property type="protein sequence ID" value="SPAL_0001224300.1"/>
        <property type="gene ID" value="SPAL_0001224300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="408"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001224300.1"/>
        </source>
    </evidence>
    <sequence length="1476" mass="168470" checksum="8830C55A24C1C329" modified="2015-12-09" version="1">MAPPENNFHKNVQQKSIFIPFASYRRKENYHIYLKGISAFLSDSEECKIQRILELLPHQTSQDYILQFSEDSLETSPSVKHLIKFVETNLSNNDLYKPHYNQLLQDLRRTRHNPNIQNSFSKLIEECLDKAKVLDEHYYEQLAIDQIIMSIPIELQIKICINPTRPSLEDVKTVLTKEDRKRRILNYKSNTEIPKPPSNPTATNKNKDTSSQSTPLRFVPSDTIKSMEDGFSSCFGEITLNDLKITTSASLDSGAGNNYISQAFFDSLPLSVQSQLDPNVKILVTNAHGGCEKLQHQKLRFLLDPLSDVVTIGMKTLKEFSVNIFECEKVQQAPKENVPLNTLNYDEQIDHVCSVLAKEDGFDKFLKDNPKAYDKDQLLQPKIFTSIRLSKDYRPKRFPILPIKSHLIDKVKEKVEEEVRRGIVRKVTDKFGGERSFAVIVDNGPNKDPRICLALLNINKYTELKPYVLPKIRDLTIFNKSNFNVVSVLDISGAFNTIGLEDDSIPLTRFGLPFGIYEYVRLPFGWKKSPEIWIEVITKLLQPVESEKCSLTIYMDDLLLRSHVSDHGKLLRQIINILMNHNIQISLHKCKFFADSVPYLGFNYSISQGLSIPIDTVSGIVNLKVPSNRDELKRTLASLNYFSSNVAGFSMMAAEFYSMLSNKDSPRSTFCWDQVTTNKFKNLLTSFAKAIALKDVPSDITNTLLYPVANLNAISVIIAVKNSTNDISIIGIHNRVLKSYEKRYSLDQKLLVASIESLQLYSPVTTMYPVDIKVDSTELINLMKSQPLIYNAQTKAQKLLIQLYPYDLSFSKKDRDCQLPDSILKTIVESSENTNQHLEEDHLRRIYSEKELPSKRRICTLQELVEAYKDDPQAKLLLEYKINPNKIALSRIHPTFRPHVSKLSIEKVGDVNIIYLNSARYIPASLIPQAVKWLHRFHSSPSSTLRFCHGRIIFQSMSTHITQFYDECSTCMENCRNRNQIISSWPIPIMARERVHGDIFFFDSRTFLVLTCAYSNFVAIYHLNSMFASELVKKIDCYINTYSLIRILITDGGTPFRSEEFQNGMIDRNIIHRLSIAYRSCSNGIVEKSIQTIKQILKKARSDGMSLQNSLIFAAEAVNNMSKGENTTARQLFLNEPSLDVDIVLKYCPYETPFKKNCWFKYDKTSPWREGKVISKISKSLFKIKFEDKFHIRTIDSIKFKKGEEDELELLPEEINSNNDILNGNDLKKDDLNINCLRDDLPMNDILKDEDSNDDALSVDALSDVSKASTKTATNVIIEENNEDSIVSQKDVLKYIEMIQTRIVLASDGNKNIAAVACYVDGHVRAFKRTLPPNGRTHGKGELLGLYMAVKIAATLKTPPILIMIDAKYLMDIIDNDGLDVSDLEFEKRGYKNSSIWIKIRTLVQENPNLIKFKHTYTRKGNLLNEAADTVTKHQDPTIALEKFKESVNSVLVPTYDKNLLQLLDQMTIDTSTSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3D8</accession>
    <name>A0A0N5C3D8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3D8"/>
    <dbReference type="STRING" id="174720.A0A0N5C3D8"/>
    <dbReference type="WBParaSite" id="SPAL_0001249000.1">
        <property type="protein sequence ID" value="SPAL_0001249000.1"/>
        <property type="gene ID" value="SPAL_0001249000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF65">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="370"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001249000.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="68772" checksum="122D47A41B5015ED" modified="2015-12-09" version="1">MHQNDDFYFDRNFLKASVHLLHHFFPRRDYRAFFLIILTLLLSIMAEVAIYFIGMVPGRFFYVLLKIEKDKFLEIIWIASLIYFGKSVIVALTSFSTSLLYLTFRKNITNSIHKRYFKGITTYKLLNNSFEKIDNPDQRITQDVERMCKNLAEKILPPALICPFIIGYYSYQTYKTASIYGCCVIYTYFIVGTIVNKILINPLAKYTARVEKAEGNYRYKHVSIRDNCEQISLYRGQYFEKIQAGYIFEKLIKIQLIHCLWKIPNLIWKNFFDNTGGILGYALQYIPFFYFQDYGDMDPEILAQVISNNAFVYMYLINSFTRLTDIAIVFGDTAGILQRVEQLLSVCKNMKDNEYTKILPYNEEDENVSYVFRNVSLMTQYGQPILKHFSFTLKNGENLLINGVSGTGKTSLLRMLIGIWKNNCGEIFCNFNIDDIEIIPQNSYLPVGHLSLYQQLLFPSIFDNDSPDISQKEKQFYELFHDLNLMTTIKRINYITENPDFEFINHLTPGEVQRLVFIRAIIKEPKLVILDESTNAVGVAMEEKMYEILNKKGIQYISVGHRDTLRQYHNTCLTLTGCGDYELDVIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C409</accession>
    <name>A0A0N5C409_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C409"/>
    <dbReference type="STRING" id="174720.A0A0N5C409"/>
    <dbReference type="WBParaSite" id="SPAL_0001269200.1">
        <property type="protein sequence ID" value="SPAL_0001269200.1"/>
        <property type="gene ID" value="SPAL_0001269200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001269200.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43782" checksum="1839DFD3F0ABD044" modified="2015-12-09" version="1">MQRSLIFRRYKITVGSKLLSLERILQTKRNDFKDYQVSPIGDVKRYIIDCMKVVGTDSNHAKMLADVLVKGDNRGHYSHGINRLEMYMRDVKTGACKGKGEPKILNDFGATAWVDGNNLLGPVVGNFCTDLAIKKAKNFGIGLVSAKGSNHYGIAGYYTLKCLENNMIGISMTNTSPLMFPTRSGKTALGTNPISVAANGKDDDSFVLDMATTTAAIGKIELAKRKNIKVPNTWGADKTGNVSTDPTEIMDGGGLLPLGGVEGMGGYKGTGLSTMVEIFCGILSGGAWGPNVRRWMSTTKEADLGQIFIAINPKCFASNFENRVQDLIDTMRNLPKANKDGLSVEIAGDSERIHEIFVDNLGGIPYHPNQIINMNEISHKYNVEPFRLLGSVEKLVKNEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C449</accession>
    <name>A0A0N5C449_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C449"/>
    <dbReference type="WBParaSite" id="SPAL_0001273400.1">
        <property type="protein sequence ID" value="SPAL_0001273400.1"/>
        <property type="gene ID" value="SPAL_0001273400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895320" evidence="1">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001273400.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12386" checksum="DD2529AC69677AE3" modified="2015-12-09" version="1">MFAVRNYSFIFLCFLLSFNMNTKIVAFSIKRNFVLNAYRNGEYLNALPGQGLMSYEFQDYGVPVVDNSGKGTYGLRKKYDRNCFFSPVQCMTSFGNTPLDTQVGWARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4L7</accession>
    <name>A0A0N5C4L7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EST1_DNA_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4L7"/>
    <dbReference type="WBParaSite" id="SPAL_0001289700.1">
        <property type="protein sequence ID" value="SPAL_0001289700.1"/>
        <property type="gene ID" value="SPAL_0001289700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001289700.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30292" checksum="9B760B6CCA2B4AE3" modified="2015-12-09" version="1">MNSLSTELKNKKQYDSKLRDDKLVYFELYNLYFHVLENKYFEFEHSLKLIAEQVQKYPESISKQMYLLSYLASQCLSKLGTKIHNFNLLKKLLSFILELVLVAEKNSTDNNSMGKRVVCVLSPYVQYFSISRSTKSLGDILSRLIKVLIFLSDSNRSEFLSLVNSNYIAIKNLSECYPGSWVPYILKTSDYQSKMNKGPTNYQTYKDSFEDSILDSLYEPPLNGFEVKKYKLKNSYNIYEEMQAFRYKLKEEMKTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C512</accession>
    <name>A0A0N5C512_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TilS_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C512"/>
    <dbReference type="STRING" id="174720.A0A0N5C512"/>
    <dbReference type="WBParaSite" id="SPAL_0001303900.1">
        <property type="protein sequence ID" value="SPAL_0001303900.1"/>
        <property type="gene ID" value="SPAL_0001303900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001303900.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22401" checksum="B04C16B16324839C" modified="2015-12-09" version="1">GTLYVERHNRIARLIYEELCRKYKLKVPKVNEKIPLLLENDEVCLRWNYTIPASTSIYHRKPDLYLHLKKEGKIFLIEVSVNALKNILRQRKLKLARYSVNGEKLLKFEEVDTVKAGNNIKKDLESRMKCSVEIIPIIVCNLGEWLMEFDVYLEKLKLDVRMKQRMSAISIHTANRIIKRHLCVAPEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Q2</accession>
    <name>A0A0N5C5Q2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Q2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5Q2"/>
    <dbReference type="WBParaSite" id="SPAL_0001327900.1">
        <property type="protein sequence ID" value="SPAL_0001327900.1"/>
        <property type="gene ID" value="SPAL_0001327900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF56">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001327900.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26195" checksum="64247E631E9C1AE2" modified="2015-12-09" version="1">MAQHFQRRRAIVAPNENVKMKNLLESHTDIVQALEQQLRRPVSLNKLVKESKFTKREVKAIYRAFKEASPNALVQRDIIREAFVELFPRGDTEHYADMVFNTFDLDHTGMISFEEFIKSMSTLCRGTLKEKIDWIYKMYDPRNTGVISWERLFFVITAMDDLIGYDARPPVTREQRIHHTDEIFNKFDPQKTGLITKDQFTNLCLNDPIILNSISHLYTVLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5W2</accession>
    <name>A0A0N5C5W2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5W2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5W2"/>
    <dbReference type="WBParaSite" id="SPAL_0001333800.2">
        <property type="protein sequence ID" value="SPAL_0001333800.2"/>
        <property type="gene ID" value="SPAL_0001333800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333800.2"/>
        </source>
    </evidence>
    <sequence length="522" mass="61507" checksum="FC45F1ED83A12000" modified="2015-12-09" version="1">MILSDELAYDDSNSCSIVTINESTELTEKKFLKSISIKLYILIIIGIISALVISSLIGVSIYFYYKYHLIFEYIRIGYGLSTNNVSFLSEVENKSIPVLWKHPLVSHINCGALLNGDSSYIMKESKELKKLKYLPNTFSTLCEDIKKRGHYPDKPLSQEEADFPIAYIRTIYKDYLTLEYQFLLTYAPQNYYCFIIDKKQPADFHNKMSALAGCFKNVHIIQNRYQMDSNGININNAYYDCMKYLNDKNYKYVVVLNVSFLNIILFFFQLLQNDDMPLKTNREIVEILKIYNGSIDIEYADPRPFYNDRVNLSLDWSLGHLEIFKEGDPRKLDNKILSSQLEIQKGYNAIFYPKETVKYFVEELNLTKFFKQLDDMNLYANDEFGFQSLIANEYLNIPGRIDADCLKKDYFFKDSYMTRYVKWIFDGDCDESETRHYVCLQNIKTLHSIKKVPHLFVNKFKGEFDFGGLTCWVEYMYDRTYFKHYKPINKSFYENLSLVKYGNLKNHIKDKEQLCEMSRSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C636</accession>
    <name>A0A0N5C636_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C636"/>
    <dbReference type="WBParaSite" id="SPAL_0000188500.1">
        <property type="protein sequence ID" value="SPAL_0000188500.1"/>
        <property type="gene ID" value="SPAL_0000188500"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001341100.1">
        <property type="protein sequence ID" value="SPAL_0001341100.1"/>
        <property type="gene ID" value="SPAL_0001341100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000188500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001341100.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18580" checksum="18409DA71DA2331A" modified="2015-12-09" version="1">MANNIKDKIEEFFEEKKNEDDIESGIQKDVKPDDDGNVKVNKQDDHESDKQVDNKSNEYGDDISEFSDFSTEEHSYVEMLSKEQQNLLNKLNEEFETNYEIVYKKLIFKNKVNSKAGLIAMTNEVSRYRVLRDRLRNCASNVDALVQELEDTMDNLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C797</accession>
    <name>A0A0N5C797_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C797"/>
    <dbReference type="STRING" id="174720.A0A0N5C797"/>
    <dbReference type="WBParaSite" id="SPAL_0001381100.1">
        <property type="protein sequence ID" value="SPAL_0001381100.1"/>
        <property type="gene ID" value="SPAL_0001381100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="54"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001381100.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15391" checksum="4E76D10725A9522A" modified="2015-12-09" version="1">MFGRLLTRTLATAARGVSLPSLQSTTFKSAVVSTNIIQTNTLHSTSSCFSAHVPLTQKQVEARIKLVIGCFDKVKKNEFSMDDDLFKDLGLDSLDHVELVCAIEEEFNFEIPDGISDQFKTPRDIFQFICDKEDVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8A9</accession>
    <name>A0A0N5C8A9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8A9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8A9"/>
    <dbReference type="WBParaSite" id="SPAL_0001416000.1">
        <property type="protein sequence ID" value="SPAL_0001416000.1"/>
        <property type="gene ID" value="SPAL_0001416000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001416000.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48260" checksum="DD7892D37939B670" modified="2015-12-09" version="1">MPLLKKVERNNLIAFWLLGLCNNFAYVIMLSAAKDILEKGSEDGYSSNNETCVENEKDIKCTNISTGSVLLADILPTLFIKLLGPLCLMNIPYDIRHILVVLCQTLSYIIVGISTSIELGLLGVVFASLGSGLGEITYLSLASHFSNDVISTYSSGTGGAGIIGALVYAIMTDQHILNIPPNKTLFFMIIIPVIFLFSYSKMLKFSKNINQVGIFNNIDTHAYEPLQRESEEEMIDENTVVRNEDVDNITVTLSYEEKKSIILSMLPYMLPLVVVYFAEYFINQGLLEFLLFTCKKGFYLTLSAQYRWYQVLYQIGVFISRSSNNICILESRYLPVLAIIQVFNLIIFYEDAKNRFISHISIVMILVLFEGTIGGKAYVSTFSQVHKETPIKEREFSLSFVAISDSIGIVLAGFSAIPIHNYICHSKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8B7</accession>
    <name>A0A0N5C8B7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OCEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8B7"/>
    <dbReference type="STRING" id="174720.A0A0N5C8B7"/>
    <dbReference type="WBParaSite" id="SPAL_0001416800.1">
        <property type="protein sequence ID" value="SPAL_0001416800.1"/>
        <property type="gene ID" value="SPAL_0001416800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
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        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="358"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001416800.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="54410" checksum="6E67C72679819F2C" modified="2015-12-09" version="1">MQPATNDYQIWREPLIEVERGRCQDTAVFLKMTDQSQQSMIEAHLKNLPIFLHVKADQIYFEISKDGGSEILDVNTVRHNSNETEHGLVLNTRENRFEHCALFKGRLQIQATNKSIDQARAKAQRAKEQETTKTAVKLDLTNKEKRKSISAKVIGDRGSKDSVTPNKKHSPTMTSRYTGQTLTELNNQPMYLRVLHVVATGKFKSVDEIVKKIKTDSYGKGDVSPNSDFAEKLASIPKIIEEITDKSQKMITLKRELHGQIDKNWKWYTSEERANVRSMLSKRPDTDIVAPTRRSGMYTLSAPSSSSKNQESSKETKEPVSTKVSVSPQIEDGEIVEESSAIPPKKKEFLLTPNTTSEDYSTHFNDIKTSEEYEKYVHLHEKEYSEYLILHNYLKEIAKKFENFQKSLSETSINTKEHQKVLRSVQSNYEHYENDGEFLRKRQRHLDLRTRLEILANKIEEWDRREKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAH8</accession>
    <name>A0A0N5CAH8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CAH8"/>
    <dbReference type="WBParaSite" id="SPAL_0001490100.1">
        <property type="protein sequence ID" value="SPAL_0001490100.1"/>
        <property type="gene ID" value="SPAL_0001490100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895607" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="600"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="1141"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001490100.1"/>
        </source>
    </evidence>
    <sequence length="1396" mass="161819" checksum="765E743AF01514C0" modified="2015-12-09" version="1">MKSSCFNFVIIRLLILRAHNLTAPCYNYRQLRAHTSTAPCYTYLLLKVTSSSLQRQFMISSESDQYSYNIVKTVLCSLFDSLPESLSHQIALENLHLSHLPHKRIRKHLIEIVAKYFTETTTEDSFTTAYEEFTYIDPATLLSPDTTHNSTTTLNQESTHTDTHTTMNTTTQTATLNSYSWMSVKEFDPKENFDRWFKTFNLHLQFDGVEGDRRLIALQLKAGRQVREFIDEIPEAERTFEQVVERLKTTYTGSLSVESASARLISYRIDYRNFRSSLNEYVKLIERANPSTRRDQLKALVEERLMINLKESLSTYLRNHRRHNTHVDEMIEDLVLENDMQQRHHKKNQPHNFHHSPHNKQFQHPLSQKKVQDSCTIHPYSRHTNSECRQQIKQEPQCKTESSHINNSLIKMPAILNDKPCNVLIDTGATCTMVSPTFAKQLGANKNTTHEYITSAGNPFFAKKINIPLSLQIDNCHHETNVDNYVASRDFTDYQVILGMNFLSPLRCSISTHEKKAYFAQPITNFLLSAQNENLKDKEEEFKQLIRQKYASVEPTCEYDVGPGLFSTSPQEFLLTPPLGIKYYASPPSEEEDEIIQQMLRYDIIEESKSLTTLPHYLLVKRDEQGKPKLQNGKIRKRFILDCREINNKTRIVPFHSLSLQILLQQLRAFTFGSTIDLHQGYFQMILDEADRPHYAFKYKYKTYQFKRAPMGARNSPSFFQNNMELLLADIRTSYQAHTNIFIYMDDILILTNGSQELHLTVLEHVILTIHSKGGKISLSKCAFLRTSLKFLSWTFSYNKITPTISPLIRNKSLPATRKELYARLQCYNYFRLSIPQYSEKTSQLYQLTKGPKQEKIQWTPELSKQFYDLSQILFNEPTIYMYDENQPLILKTDGCNTGIGGFLCQRDQEGIIRPLGFFSYPLQKTKTPRSPTYIELLAISKGITTFRYLIQGKQLTIESDHRPIAGLIATSTSPKFMEHINTITQYTTDIKYINKHCNQLADFLSRLFENSRSEINNLQDAPQQPRRRGRPKKVQNTTALEKSQPRPRGRPKKLINPTTNNDGRYIEYESLPLDLSSIQKEDGELISSLEQGNYRGIKIETFNDIIITSDSKRPIITDEQTIQAILKICHDQTGHWNHIATKEIIQQVVYIPDLSTKCKAYASYTLPKILRTDGARYWTSKEVSEYLKTNQVIHSISTPTNSTGNAYAERFIRTLQSAIGKLLLDYPQSEWDTILPEAVYALNHYPRQGSTPFQRILQYAERFIRTLQSAIGKLLLDYPQSEWDTILPEAVYALNHYPRQGSTPFQRILRHKPTTVLQLAMQKSLSKDKLNEAKQVMKTLEASAYIPVKRRTKFQPRFEDQAHVKGISKDGKTLHLQRNDRSYIRPRRNAKLRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAP4</accession>
    <name>A0A0N5CAP4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hyphal wall protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAP4"/>
    <dbReference type="STRING" id="174720.A0A0N5CAP4"/>
    <dbReference type="WBParaSite" id="SPAL_0001496400.1">
        <property type="protein sequence ID" value="SPAL_0001496400.1"/>
        <property type="gene ID" value="SPAL_0001496400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895621" evidence="1">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001496400.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="44480" checksum="0872F4820B155AE3" modified="2015-12-09" version="1">MKFAISFIAISFLVVSLSGAETTSVIRAKRQSCGTSGYCGNVCCNQVPQQQQNNCQCQDSTATNCPCSITIEISQGQVQPQSGCSCQQQQTSCPCQGSPNCPCSITIEINQNCGCQQETTTTTTTTTTTTTTTTQAPLCDCPPVQCLCEPVTTPAPQNDCICNPCLCQPVTIPAPQNDCICNPNPCLCEQPQTTTTTTQAPLCDCQPVQCLCEPVTTPAPQNDCICNPNPCLCEQPQTTTTPAPLCDCQPVQCNCQQEPVQIPQNDCGCQQQVNCNPCEVQVQVEVQQDCNPCATQVQQDCNPCATQVQQDCNPCATQVQQDCNPCATQVQQDCNPCATQVQQDCNPCATQVQQAQPVYLAPTQVPVQSQTISCDSSTTCQCPTYYVQCAQQTCCLRYQYANRRMKRSTGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAY3</accession>
    <name>A0A0N5CAY3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid synthase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
            <ecNumber evidence="2">1.3.1.39</ecNumber>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
            <ecNumber evidence="4">2.3.1.85</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="67 68">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="68" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="62">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="62">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="55">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="58">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="58">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="59">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="59">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="60">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="60">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="51">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="61">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="61">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="63">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="63">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EC" id="1.3.1.39" evidence="2"/>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EC" id="2.3.1.85" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="STRING" id="174720.A0A0N5CAY3"/>
    <dbReference type="WBParaSite" id="SPAL_0001504900.1">
        <property type="protein sequence ID" value="SPAL_0001504900.1"/>
        <property type="gene ID" value="SPAL_0001504900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
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        </source>
    </evidence>
    <sequence length="2620" mass="291674" checksum="CD39BA2600AC3F85" modified="2015-12-09" version="1">MEKSIHNSENLSSSWERVSDMSSSNASTENIHASGDSTFWRGQDDIVITGVSGRFPRSENMAEFEQHLFAGDDLITEDDLRWTPGLFGLPNRHGKIKDLKKFDAQYFGVTPKQANFMDPQSRLLLECVGEAMIDAGLNPKDLRGTRTGVFVGCSASETSGALTQDPETVTGYTLTGCVRSMFSNRISYTFDLRGPSFSVDTACSSSLCALQLALDSMRQGQCDAAIVAGSHITLTPTAALQFLRLGMLSSAGACKTFDESGDGYCRTEGVAAILLQRLPTARRVYATVVHAKSNTDGYKEQGITFPSGERQAALLEEVYKEANVDPNTVTYVECHGTGTKVGDPQEVNAICEIFCSNRTPTNPLLVGSIKSNMGHAEPASGLCSIAKVILAMERGAIPPNLHYKTPNPYIPGLSDGRLKVVSEVTPFKGGYVGINSFGFGGSNTHVLLKAADHKVNEIKDKTNLTRILVYPGRTQDSIKEIFRNVENNKENLYLQSLLYNQIDMSPKDAPYRGYMLFNRKGTDEVVVDIQKVSQNENRPIWFIYSGMGSQWPGMAQGLMAIPLVDESLRASSKCLERFGIDVYGMLCNSDPAQYQNNTLNCMLAISSIQIALTDLILYLGVVPDGLIGHSTGEMGCGYADGSLSREQTMELAYYRGTSIMESKLPIAGGMAAVGLSWEEAERRCPKGVVPACHNGAESVTISGDADKIKEMVDELTKEGVFAKYVDTSGIPFHSPQMYPVRDAMLNAMKKAVLEPKERSSKWISTSIPESEWESDLAKTSSAEYHVNNACSPVLFYTALQKIPPNAIVIEIAPHALLQAILRRNLPKTCTNIGLVSSRADNELEFTLQALGKIYQSGGTIYPQKLYPRVPYPVPKGTPMIGSIWKWDHSQDWQVVDGKMLATCGGGQVPASASYNIDPFATDSQDVYLLDHCIDGRVLYPFTGHMVLAWKTLCKIKGVDFQSTTVVLKDINVFKATILSKPIRLDVVVTPGTGHFEILDEDQVCASGTIYIPDETQPPYYDNMENIETAPIADRIELDSDDAYKEFLLRGYEYKEAFRGIYKVCNSGEKGKLYWTGNWVTFLDTLLQTSLLAERNDTLRLPTRIRYLRIDPVKHLESVIDQDGLQLVELRNDISTNGCVAGGVECCELTSNTVARRMQISGQLYLEKVMFVKNVDDNAFNEFPKDAANLRSYKDSLKALLYEGLCKWKKAGVLDGFKNAKVFDAIVEELKKSGAKSNSEMTTSYIEESQYSLYRTLNDIFNETTLNKDDKAEEVVVNKVKSSYKIFDNDKLWAAAFIHDRIIKVVHDLIVENSAGHKCKSAVVNISTTEALKYLIKSIESHPLLEVDWTATGTNVNELDENTLTQLGVNKQTINFDSPDTKPGDGKPYDYMVIDKVLNQKEDPVAFIKKCGEFLRDDGFIIVNEYTRDFEFVSGVELLNGRELSIFGAFYTHDMLVKVFEEANMMLVSYQTDPSMLTTMYVIRRIPSEPRDPVVVNVDDVEKFEWIEDLKVKIEERLSEPDSKTIWLVSDKVRNNGVVGLALCFQEENLKNNRFRTFCDISVKKSNRTGPPAISLTSDEGKKIMKYDLHANNYKDGEWGCMRHLLVKDDDAHVYKECEHAFINTLVRGDVASLKWFESPNQFYDYFPNKTSTQDLCSVYYAAINFRDVMLAYGRLPPDAIPGNFADRECLLGMEFAGRLRNGKRLMGILPAQALATTVVVDTDYSWEVPENWTLAEAATVPVVYATAYYALVMRGQIKKGERVLIHGGSGGVGQAAIAIALSYGCEVFTTVGSEEKKQFLMKRFPQLKEKHFASSRKANFETYIRRVTCGKGVNVILNSLAQEMLQASVRCIAQHGRFLEIGKVDLSQNSALGMAVFLKNVTFHGILLDAIMDTTVGCKDDWLQISDLLKRGIASGVVQPLPYTSFSSEKAEDAFRFMSAGKHIGKVLMEIRKEESEKVCVPKPIKVKAICRSLCNPTHSYLITGGLGGFGLELAQWLINRGARNIVLTSRSGIRTGYQARCVHFWRRSGVNVLISTLNIYNESETYSLIQQCQELGPVGGIFHLAMVLRDCLFENQNVKNFRDSAEAKYYGTMNLDNVSRKLVSNDTLRWFVVFSSISAGRGNAGQTNYGWSNSTMERMIEQRREDGYPGIAVQWGAIGDVGVILENMGDNNTIVGGTLPQRMPSCLATFDLFLSWNHSIVSSYIKADNVNKKSSGSGNLLQTIAHILGVNDISQLNPDTNLGDLGLDSLMGVEIKQALERDYDIVLSMKDIRTLTLNKLQQMAENGGNGGDEKFVTTEQDLMNEKSKDAENNTVEALEKQLNQLFKLRVDVNDLEPEEILIKCNKVEEGPKVFFLHSIEGIATPLMNVMKKCSYPAYCFQATKDVPIDSIESVADKYITEMKKVQPQGPWRLVGYSYGACIAFEMATKLQQTDGENAVERLILLDGSHLYMQTYRDVYRKAFGVTGDTLINNPLFETEILVALTFRFANVDYKKYRMELLQLPSFKARIQKVVDTVMTTGLFKSPDTIQFACEAMRSKFIMADKYRPVRKFNGHITLIRAEQGAAREEDVGSDYGISQVSMDSQVFVVPGDHDTFVQGKNSSKTIELINTLVEKSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB75</accession>
    <name>A0A0N5CB75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB75"/>
    <dbReference type="STRING" id="174720.A0A0N5CB75"/>
    <dbReference type="WBParaSite" id="SPAL_0001513800.1">
        <property type="protein sequence ID" value="SPAL_0001513800.1"/>
        <property type="gene ID" value="SPAL_0001513800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001513800.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50001" checksum="E35B237AAB772050" modified="2015-12-09" version="1">MSISTIRRQMKNVACNYSDAQVKVREATSNDPWGPSTVMMSEIADLTYNPAAFNDIMVMLFKRLNDHGKNWRHVYKSLILLDYIIKCGSEKIAQQCRENIYTIETLKDFQHVEDNRDQGLNVREKAKQMVLLLKDEEKLKNEREKFQSTRRRFIQSGVGNVSNTTGVGRVSELEDARPSSIREEEIQLQIALALSKEEMKKEEDIRKGFQARLQHALEESKKDTSDFLPTDNNFTIPNTTTSAENNIEKKTPTNVIDDLLSLDFGESSVQNCQTLNSSPPTVNDPWAPIGNVPNNQNINVSNVNPWDIVTPNQPTTTDPWSTNNTNVNLLSNTDSTMSTNNDDKSLITEKNEPRKNSINVEHFLGPNSNLVNLDNLMGSTSNSTITRTSANPFLPISQQPINPFLAQQGTPLTLNELMQAEQRSQEKPNVQNSQNINNTFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB87</accession>
    <name>A0A0N5CB87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB87"/>
    <dbReference type="WBParaSite" id="SPAL_0001515000.1">
        <property type="protein sequence ID" value="SPAL_0001515000.1"/>
        <property type="gene ID" value="SPAL_0001515000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="82"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001515000.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39837" checksum="D79185D3E0ECCF4C" modified="2015-12-09" version="1">MASLSALNETFYNYNYDYDYQDDDYENILKDKKNFKLLIGSCYITYTLILIIMQSILFITFFKQSSILVSMPYRIMLHLGVYSLFQQICHFLSGNFLIFDLKLQTWYGYAIGSLSESSYIASVTFVFLLTINRFDVMFNEQIFPSINRKLFFNSLVIICHSFFILLFIFFLLPDFRVYYSPGCFCWKFEKPDNKHYIAFQVQNKTVVTLLTLSLILYLIIFIKVIMTRCSKSSQKQRVLSDIRILLQALFNYVTVVFLEICLLFSNEFFWEFDNGYSIIDLINVIICGNNTILTYIMSSDIREKTFETVCGCLTSNNKVNILKNSSNRNNTKSKHVNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBD7</accession>
    <name>A0A0N5CBD7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBD7"/>
    <dbReference type="STRING" id="174720.A0A0N5CBD7"/>
    <dbReference type="WBParaSite" id="SPAL_0001520200.1">
        <property type="protein sequence ID" value="SPAL_0001520200.1"/>
        <property type="gene ID" value="SPAL_0001520200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001520200.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20262" checksum="D5FB3EEE9CE17E11" modified="2015-12-09" version="1">MGDHHSFTLIKDDLVFFRGEKSLCSNFYRSPFTDPETGYRFLTVEHYYQFHKALYSGDQQSQLEILRTDEAYKVQRIGHQIKNLNRSGWEERKISVLYKGLKLKFSDPILKNKLREYYVSSPTNRKFIEISKSNYWGCSYKMVVNNSKNADLYGRNNMGKLLTKLDNELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC95</accession>
    <name>A0A0N5CC95_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC95"/>
    <dbReference type="STRING" id="174720.A0A0N5CC95"/>
    <dbReference type="WBParaSite" id="SPAL_0001550400.1">
        <property type="protein sequence ID" value="SPAL_0001550400.1"/>
        <property type="gene ID" value="SPAL_0001550400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001550400.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30281" checksum="7FC41BA9C3E8920C" modified="2015-12-09" version="1">MAFSQPRQSKNDWSDDDEECDMELDLGSTTIKKPMDGGSLWSNVITEQILEEGTSTTSVFCDKGFSRDIESYSIPKDVKVSAEEKKETLIFDKKKFCADLFSDFGTNNDDDTEFGVLGSGTKIPSSGHMKSNGRKREKAHNKKPYTKSGGNNKKTERYADKMILYYLPENCDNDTLVKAIAEGLSERCVDLIERSVYILGQERCREIFEMVRQTEMAGGLKTLDEKRRRSPGGIFIYHIKNHPEITKQQKKYVINPPKKKEEAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCM5</accession>
    <name>A0A0N5CCM5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCM5"/>
    <dbReference type="STRING" id="174720.A0A0N5CCM5"/>
    <dbReference type="WBParaSite" id="SPAL_0001562700.1">
        <property type="protein sequence ID" value="SPAL_0001562700.1"/>
        <property type="gene ID" value="SPAL_0001562700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF20">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE_C4-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001562700.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42726" checksum="0CFA749713857BA1" modified="2015-12-09" version="1">MGQSVSRTDYVWTYTKQPHLSRREAIIRDHPEIKQLFGVDPSFKYVVTACVLLQTLAAFLLKDSDWLLICLQAYFFGGVVNHALTLAIHDISHNTAYGNHRPLANRFFGIWANLPIGVPISISFKKYHVEHHRYLSEDGLDTDVPTLLEAQLFTTPLRKLLWLFLQPFFYAFRPLIIYKKAPTDLEIVNFIIQLIYDFMIYYYFGFKSLFYLLFGTFITMGLHPSAGHFISEHYIFNLDCTQETYSYYGPWNLVTYNVGYHVEHHDFPYIPGKNLPKVREIAPEYYDNLQKHESMIKVLYDFAFNPTVGPYARIKRKASIEQQVYGNNMLLPYIKGFFNYCGITFITNAIENKFLRCNKQLNKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCT9</accession>
    <name>A0A0N5CCT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCT9"/>
    <dbReference type="WBParaSite" id="SPAL_0001568900.1">
        <property type="protein sequence ID" value="SPAL_0001568900.1"/>
        <property type="gene ID" value="SPAL_0001568900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF10">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001568900.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="9009" checksum="029BFEC692D13C26" modified="2015-12-09" version="1">MIVREPISRFISGFIQICVLNIGLQQNHSNCFNCRKNMKCFIERLYNHTQNLNRKLTNTNIFIMYHFYPQSWYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD32</accession>
    <name>A0A0N5CD32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PABS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD32"/>
    <dbReference type="STRING" id="174720.A0A0N5CD32"/>
    <dbReference type="WBParaSite" id="SPAL_0001577800.1">
        <property type="protein sequence ID" value="SPAL_0001577800.1"/>
        <property type="gene ID" value="SPAL_0001577800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001577800.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43486" checksum="55A99DA574DFCDA3" modified="2015-12-09" version="1">MFKCSLSNYTHQILPYFIYKILSILYWLMNKKICLYTTFLTTLLITLYHLHQDIINNENYFSGVSYDEKNVKTIDKLCSITFQNTCYTIVDRYLEDGVVERSVVLNEDFRFMETSVQLIKPDGSDFWNSDTKLWKVNHSYIEGDYITILAAMPFAIRAIPTSFNTKGNLLEIGLGGGSLSMFLHTKYKNLNLTISEIEEKMIIIARKYFDVPYDKQNFHIKHEDGIKTIKNAATSNALYDIIILDACGTDDIIPCPSQPFITDDILNKIKKILKPTGILGINLLITNENNIYYFKHYMRKFLEKFPTCIYAYSEIELNYIVGCMQYSISNLEESEELFQKNYEEIIDQWNLPSFLKEIKMKLINKSRLETIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDC1</accession>
    <name>A0A0N5CDC1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF721 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDC1"/>
    <dbReference type="WBParaSite" id="SPAL_0001586600.1">
        <property type="protein sequence ID" value="SPAL_0001586600.1"/>
        <property type="gene ID" value="SPAL_0001586600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001586600.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16237" checksum="D2BE57969062D3B3" modified="2015-12-09" version="1">MKKNKRNSSYINPERNNFTENNISLIRQRITVKLKNYLEKSGCIWTRNSKEKNDCTMLLLNISIPSSDIIAGMVKLYIDEIHQVPKEFCNDKLTIIINFEEKNISDQSLKEKMEKKKKIIDKCLSGQSNKSSLPKKAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE01</accession>
    <name>A0A0N5CE01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE01"/>
    <dbReference type="STRING" id="174720.A0A0N5CE01"/>
    <dbReference type="WBParaSite" id="SPAL_0001609100.1">
        <property type="protein sequence ID" value="SPAL_0001609100.1"/>
        <property type="gene ID" value="SPAL_0001609100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895779" evidence="4">
        <location>
            <begin position="24"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001609100.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="78902" checksum="FC24BBC43168292F" modified="2015-12-09" version="1">MKTIFSILFHCFGMSFLINHVLATCPRNIKEPCICQNGDHEPLQIYCEGATSFNVILEMLKPVRNTIESLSVVDTAIPKLEENIFEGFIFKRLSLIHNDLHEIDENAFSGDLLESLEELEIRRNALEEIPISGISKLRYLTLLSLAENEITTIQDNIFLHYQSRATLQTIDLSMNQISVIHDNGFLGLENIVTLLLDRNLITEIPSKALINIPTIEQIGLSVNKIKTISDGLNLPVLKSLSVEANQIKSISPNAFSGTPNLIYLYIGSNQLTNIDEIVFKPIFNLKILALSNNPGIKEIGPLAFKHTPNLIRLELSQCGIRKISDSSFVYVNKLQILLLNGNALTYISNKLFTSLKKIENIDLKNNQLSTIEDGSFVKLKSLRTLDLSNNKLTYINDNLFQDSGIESSSQKQTNVYLYDNLWTCDSNLDSFRQWLRNHPYIKIETETSKPARCFNPPVVKGLELRKVSQSMLPPIVSEQTQRTINEFKNLVQQPVNVKNSETLSTSILTTTTSFISKKENSNINNNNKNILVNEKKIPTNGNAIPQLHAYPSPKITKITEGVGSDRNNMTNVDKENVSIASQPVNMVIIIGAIIASFIAIIGLIVIILYIFRTKKVYKRRGVGTVSADEFAHKKNNTMMSGQYGKDTSMYGNNFTLVPGFTAHTIKTPQNGNEYGNDNLNRQNFDPEGGYYLDRPWYWWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIK1</accession>
    <name>A0A0N5CIK1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIK1"/>
    <dbReference type="WBParaSite" id="SPAL_0001765600.1">
        <property type="protein sequence ID" value="SPAL_0001765600.1"/>
        <property type="gene ID" value="SPAL_0001765600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7584" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001765600.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17798" checksum="240D0730D616D621" modified="2015-12-09" version="1">VEGAWVTTIRVTSQSQRYYSDSTFTIFGYELVQLEYYCKDEENETPRSRLLFSGPKDEGPTATKLATKPTLRTLTFPTSPFSCMMGILRTETQDYMGWLVVRGDDTIVVLEIMDFELLVEDQPYGRLHSSKKLWRRRILELLRLPVNKIQGACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1W8</accession>
    <name>A0A0N5B1W8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF229 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1W8"/>
    <dbReference type="STRING" id="174720.A0A0N5B1W8"/>
    <dbReference type="WBParaSite" id="SPAL_0000006900.1">
        <property type="protein sequence ID" value="SPAL_0000006900.1"/>
        <property type="gene ID" value="SPAL_0000006900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000006900.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="78778" checksum="1AB99EA93EBC04BB" modified="2015-12-09" version="1">MLLIKLRRLYGRFPRTLILFICCTIITTILLLSIFISKEDNPYSILEYSKIDAKNIKVHLTNSTLTKFDQDKCIIPKLTLWSKQIREFYEEKDIIDCGKPTKEWILFKDQQLIINEDSYAHKNDFYCTITSIILIDDYNIKKNVKTIEKFPFTDFESDFFHLHCYSKIDYNKWNKYFMRAIVDKKNIQKLKKRSDDSLNVHIISYDSLSQMAFRRLLPKTIKYFEEAMEGIVLNGYNIVGDGTPQAFIPILTGKTEIELPVTRKTEKNPKYVDEAYDFIWNTFSKNNYVTTYGEDIFSTGTFQYRLMGFKNKPTTHYTRPSFQYTESYFGNDCFGETPQHKEWLDYSTSIVEAYNKLNISRFTLLHHSAMTHDFTTKGANCDEDLYNNLKYNFEKMKFENDIVILMADHGHRFAKFRQTHQGQLEERLPMLGISLPKKFRNTDKGKLFYKNLKNNQNVLTTPFDFHESFFDILSPPDISILNKEQDTTTRGLSFFRPINKERTCFQAGIETHWCTCLQWTNVWNKPLYQSAINETAKIFVDEVNKLLKPEISLCSPIKLDSILESKWLIPNSKMIHYKGSLDKDGFIPDTSGKTIISKALLKVKLSTQPNGAIYELTVPFNFDTTEMKINMWTVSHINRYGNDPHCIIDRIFKLATYCVCWDKVITNHKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2T5</accession>
    <name>A0A0N5B2T5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2T5"/>
    <dbReference type="STRING" id="174720.A0A0N5B2T5"/>
    <dbReference type="WBParaSite" id="SPAL_0000038800.1">
        <property type="protein sequence ID" value="SPAL_0000038800.1"/>
        <property type="gene ID" value="SPAL_0000038800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="152"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000038800.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46733" checksum="E59C1B9F9ADFDE98" modified="2015-12-09" version="1">MSNTIFLKGESNCAVCSDKATGVHYGVLSCNGCKTFFRRSIVKNKNYVCLGVEDCDVSKAGRCSCQFCRLKKCITVGMNKSAIQNCRDKIGYTKRNVKKRCTNNEPDDKNITNDYCGFQIENDSSDMPGFTQESIKIFKANFRKLKKLEDTFTLLLTRASLEAYPNLNVGINSPSIFARPVDVTYSHPIVQPTMSDEKYKVPFWRSRIITLYVDWAKTFKAFNKLPYSDKISLIVNHAPSYIAMCEAFRTPNHISDKIEHPDGHSFTHNFPEVFKINPNLNTLTPAMKLVFNFICKPFRKLKITTTEFAILQSIMLFDPDTVNLGFASQRNIMAEQKKHINTLLYYISKCYADEDVANQRFGDIILRIPTIRKVAIKISESLEFTDMFQCYKISSIVKETSMPDHINIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B373</accession>
    <name>A0A0N5B373_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B373"/>
    <dbReference type="STRING" id="174720.A0A0N5B373"/>
    <dbReference type="WBParaSite" id="SPAL_0000052400.1">
        <property type="protein sequence ID" value="SPAL_0000052400.1"/>
        <property type="gene ID" value="SPAL_0000052400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000052400.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="42920" checksum="49DEB6957BB185A0" modified="2015-12-09" version="1">MILTVIGNIYYDSLDNSDNVGTITDDSVNNKLHPYQIAIVMVIESASESNYKQAIETVKCYSLRYNYTFVILYQEKVPEFSYNCHYRDFMFRIHCIIANYAQKYKKEIKYILFIDGDIGVVNPPHGLENYLSKDGDDILFYDRTFNYEIMAGSYIIRNTLYTRSFLKFFADYEYKMPKTNDGRDNVALQAVFVDFMGTVEHRNKYLQCMKIYNYAIGYDENMLFVSCMRYILNLMDETPNDTNYHTYDGGKIKILRKLSKKRWARDGWLSDWKFCNYDLFHHAWKQEEIKKHRIVFKRRFLANKKKCKGSDFLKLWDYDKSFKRNCKVVDNYIKLYVDYAHRHYLKEIIESNITEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4A8</accession>
    <name>A0A0N5B4A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4A8"/>
    <dbReference type="STRING" id="174720.A0A0N5B4A8"/>
    <dbReference type="WBParaSite" id="SPAL_0000091000.1">
        <property type="protein sequence ID" value="SPAL_0000091000.1"/>
        <property type="gene ID" value="SPAL_0000091000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000384">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF399">
        <property type="entry name" value="BLOWN FUSE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="266"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="435"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="684"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000091000.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="88960" checksum="E837A557A8D9F5FC" modified="2015-12-09" version="1">MVHYNKYMNFIEAIKDSPNFRASLHDNELYLGGFRKRIEELITTIDHVLSLEEQLTAASGKLNICFSEVWKSMKNNDPVSDVTFSTVSEGFSKIMNTNGSIHESSFLSMRNVLINFLKGDLERLSETKSQFNSISSNLEEALTKKAGISRQKANELNEAKNSLTAIGTCFAHVSVDYVAQINLIHAKKCYILIEAIWKFLNEGTNYYKKSYKTLIDFVDREGQGISDTISHLKCNFKVMEKKMQDRHSVVPKEMFSHPAGLSLDPEVVMEGYLFKRSSNAFKSWNRRWFQIKDNKLMYSHKNSDTEQLRVMEDNLKLCLVRPAPPNIERSCCFELVTPCKSHMLQADSDLLCKSWIRALQRTIQHLHEETFQKPVKEVNIESEESEGQQLNDNNITNTYGCDSSESNNSTPRQDLQKYDIQDPPLKKFNNALSIREFYSHVRSIPGNTICADCGCLDAKWISINLGIIICIECSGVHRSLGVHVSKVRSLTMDSLENKQQEVMLSLGNDIVNSIYMKYYNSWSNDYPLITKDSSRSEREQFIKAKYVKKIFTERAPTSSNGIKIFDNNCDDNESEVTHQYLLLPTNETLSIKSFDRPESRLSCDSETTKFDHSGNDELFLPDKVYDVIKNNDIVKMLELLANGFDINSLIQGNTPLHIAVKYNNQAMIEFLILNGGKINAFNEDLDTPLNIAVTIGDPLLVYQLIKRNADKSIKNKRGLTPLECAMENEHANVVVLFRLVDLKDECTNVDSNNTMLDENIDDFLSNLQIQENEFKESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4S3</accession>
    <name>A0A0N5B4S3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otopetrin-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4S3"/>
    <dbReference type="WBParaSite" id="SPAL_0000107200.1">
        <property type="protein sequence ID" value="SPAL_0000107200.1"/>
        <property type="gene ID" value="SPAL_0000107200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF33">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000107200.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65136" checksum="F667510C12F0382C" modified="2015-12-09" version="1">MNEEGSIDMINNAWIYNSKAKNMLITSFSAFYAFIVILFALVLELAQVYDVENNEKTNSQGNFNHTIHYNYSDTTEGQFNNYKNILFGIYMYGGSLAIFIFFYIYLLFKKTPSINKCLNSVSSEVSIESVVTDSGSLTSHSRNVTHDRPSAGSLFERLGMVIFGIIGVVYYAFPLFIYVGDHEYKALKLLQDILSIIFFFIQMHFLFCNSSLNINSYHYLTKFGFMHLIATNIWTWIRYILIEETHMKHEIKDIVLADEELLTIYHNNNNSLYLESSKEGHSCNGASCVMEHFGAIMYTCIVEYSLICAGITFSLWRNMSICKNKDLTYVSRKQHIRIDCSNTTTGLFSGLAFFTTTLTCTAAFYSFQMVHEGQKAIVLFNATDLLQYSITIFVCCFAAWRMRFFQYNDVKSVAQRNQQYLDSLLLLLGVMGELLYSITGVVGLLGAKEFNSFNTLLIITHLVRLCQVATQSCLIYIAMHLKACTEGIPNKKKKPGKEIITFLIICNLSMFIMNMLETGHVGASEEIVNFYGKYSWIVLVRSFSPLTIFFRFHSAVCFVEVWKNVYSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5D0</accession>
    <name>A0A0N5B5D0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5D0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5D0"/>
    <dbReference type="WBParaSite" id="SPAL_0000127300.1">
        <property type="protein sequence ID" value="SPAL_0000127300.1"/>
        <property type="gene ID" value="SPAL_0000127300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF18">
        <property type="entry name" value="PAN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893762" evidence="2">
        <location>
            <begin position="18"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="205"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="300"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="445"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000127300.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="90493" checksum="048A5F712B188766" modified="2015-12-09" version="1">MYLVLFFLGILIKLGLSSRDPCENGSYTFTKATSLTIDKNPFKTSSANSRTSCWLSCLTDNECSTFSYNTNNGTCNLFVDNGLPFGSSNLIVTDDPADEFYQSLCIPSPSLCNTSSSFDRYPQYLLLGHSEKVIKQTSGLQECLRYCLEASGLYNINCRSIMFNYENNECILNSMTKNDYPNLFVPNDKNDVIDYFENNCIDISCANGESTYWIEAKYFRNITNSDTYVVYENTPKDRCIEACTDNECINEEGFNCKLMIYDDDTRECILSKGSLIGGDQIQDENYFYKEKICLQSDVKCNGNAFEAISNHYLNITSETLFDISLSTCLEACLKWKKTCTSVSYDKNNKKCHLQEKSRFSHPRLFIYDDNMIYFDNICEYDIITYIKHNNKKKEKVLTHGEGSFSPKFSSQIPVDDKIIKENNSGDGSSSLNRNTIILEGPLKTICQSDGIEVIANFKSPSDGSISIKDHSLKCKSTFSRTKKAILNIPYPSNEETNPDCPGSEEEPGKWTFIVVVQENTNNLQGIVDSNDQVFKITCDYTKQQHHSPYSIIHAANLHSNEVRNEVKNNEENYGDMYMGLYLNDKPVTKVNLGDEVEIRWIMESREKIDYSVESCIAERVDGPPPQPPPLQLYKYGCPDSKVKGHLITGPIQKINNGYSSTMKIFRFEGSKKVRIRCSINVCLDSCSKAICQDNDNSSTENFIDDNNVTSNSIKKRHSEMDQEKIITGVFSIIDSNILNNVQNMPLEDVKMTPKDYCFSKITFEGLAILIGLSFIHSITSVTIAIRKRFITKRTNDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B636</accession>
    <name>A0A0N5B636_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B636"/>
    <dbReference type="WBParaSite" id="SPAL_0000152600.1">
        <property type="protein sequence ID" value="SPAL_0000152600.1"/>
        <property type="gene ID" value="SPAL_0000152600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000152600.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24326" checksum="2F0335CB8E4270A1" modified="2015-12-09" version="1">MICCFNTQKNIEKKPFATTKTSTSSYNEFDILEEEIQDIRMIFYGYIDILMLLKLIAIVIILWECLGFYLAKQEFVMYGFIVLSISSFLLFCAIITAIQEENKKYILTIMILFYFKILLLILYLGIVVVTVYTDEFIPHVHKYFIQDSIEVIGILMLIIFFTTIQILLTTKAYRYFMLRDELYTIPSVKVHQIRPELAHVLTKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6L1</accession>
    <name>A0A0N5B6L1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TATA box-binding protein-associated factor RNA polymerase I subunit B</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6L1"/>
    <dbReference type="STRING" id="174720.A0A0N5B6L1"/>
    <dbReference type="WBParaSite" id="SPAL_0000169900.1">
        <property type="protein sequence ID" value="SPAL_0000169900.1"/>
        <property type="gene ID" value="SPAL_0000169900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005668">
        <property type="term" value="C:RNA polymerase transcription factor SL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000169900.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="90087" checksum="65ACC71BCCF3E19F" modified="2015-12-09" version="1">MSLECANCRSSDFYLEDGYYCCKECGAQTDAVDYQEVVTNVHFSHSAGKDAKEKVVDEKKSSKVGAKQQYFGRSFYNVDDFNECLDRIGTRLASSTQIIYSICSVLVEKCGASEDLYDVCMGLFQKYLATYKVAFCKEELNDGSEEIFSIQIRLKERELNRLIKERQKQANELMEKEINDRLMNLDLFGPIGNVEERERRQVDNFNITLKPEDYYRVRETSVSKKALTRAGHIYLNLDMLIAIIYMSLVYTGTHFIQMADLLRWQREGRFPVTQDHINDIQIVNYDNTSSTFKVQHQICGENLQKTNSSPLSKCNYSSMFLWQFLSLPRLVLPLDSFDELVGRYIYDLNLPKSFGSRIQEYRKIFNPLKNQNCDLWKEYFPLIDNCVDVVESQFTTEKGRNDSSNFYKITLPKTFVRQRLVDTSFIDIPIEVKAMALILFAIKQEFSFNNKDEFEKPNDNDCFYFVDWLKQLNFRTQLADGKSVDYVTSERNLYTFKCGDKKVYDHRGYQLSYMFNDQFDSKFDHQIPSKSRMFMNQKLLADGLEGVNYVPRESNNDGVLFTPIKFYGEECICENSLEHNDTVLLIKKDFSNYKLKDFKDIEEKGHYLFPPADGVNCLSTERKFNGEETRCSIYFSTQNLLTVYESIRDSLPKLFNQLLYLLSKVIGEWPHILYFAFLAVENAIVYREEFELFKTFLINNNGVVIGKHQKGNYCVAMYLNNSEGNFFDLKIKKYVEHINYSSSSDELVPKHFQSFSNSTIPHIGLCLKNHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B734</accession>
    <name>A0A0N5B734_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B734"/>
    <dbReference type="WBParaSite" id="SPAL_0000186200.1">
        <property type="protein sequence ID" value="SPAL_0000186200.1"/>
        <property type="gene ID" value="SPAL_0000186200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="359"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000186200.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="71719" checksum="7618ACDFC661D63B" modified="2015-12-09" version="1">XRTFEGSRDSEKFQTPLRTSTPIKPPLSLTAMTTAPTPTTPSSSWMSIPIFNPADSFEKWHRTFDLHMQFDGITGERRTIALQLKGGKEIQDHIAAMSEPKTYELVVESLRETFTGSVGVEAASARLVSYKFNYANEKFRKSLSDYIDLVEKANPSVPQDSLKSLIEERLMRLSRHLRLQRRHYKNTQELIEDLNFENEMQNRAHQRRLSSNKSDNFRRRTYPTLVNDRCKVHPQSNHSNADCRQQHPPKDPQPKNEVFHISKFSSQLIKMPASMNDERCTVLIDSGASCTMISPSFAKLLKIENSTSPEYLTTAGSPIIARKIQIPLMLRIEDCHYQTSNENFISPHEFPDYQVILGMNYLVPLKCSISTSNKTATFTQPSTSNFILAPPTDDIQSEEEKFKKMLKMKYQSIEPKSEFDVGPGISVYGSTIDLHQGYFQMMLHEQDRPYFSFKYKYKVFQFKRAPMGAKNSPSFFQSNMELLLADLRTRVQGHSNIFVYMDDILVLTKGSCQLHLTVVEDLIKIIHQKNRRISFNKSCFLRTSVSFLSWTFSRNTITPTISPHLLHKPLPITRKELYSMLQCFNYFRLSIPNFHERTKDLYQLSKGPRNEKVPWSQDLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7R8</accession>
    <name>A0A0N5B7R8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7R8"/>
    <dbReference type="WBParaSite" id="SPAL_0000209200.1">
        <property type="protein sequence ID" value="SPAL_0000209200.1"/>
        <property type="gene ID" value="SPAL_0000209200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209200.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53906" checksum="56735607EA6D1AB5" modified="2015-12-09" version="1">MDPYNHNVGNPSMSNKALPYSICQTISATSNYLLPNYTNQLGQIPSLSSSVTPCSETMSGGYTYPYESSYYQQQLISNNIYNNQGNYPLNKTTQTLRSINYAIENSLNPLMNTYQQPITENCISNSRNFQTQQWMQNHYFDSQSYNVATPSCTPSMMSNMSHTSITNANPQINCQTNGIESGRMTELKSIFKTESYPNSVVSFTENLDPSQDQFTEDCRKNILNNLLDDDIEVRSKAYKIIKYLSIEKENQARPFIMDIMNTIGIDRTNSLNLERLLECLCHLTYNSKTIGCIINSILDNNLVFIDTLGKRIVKDQFNRYGYGYYALSILHAILSLSGDISKILTKYTRKPFIMDRIFEYFNKILTISSVNLYDQSYYFERKEIIWLIECLKHLILDNDNMKEYSLSKNGVEILLKILKGSQREYIHYHALSCINAFIQSGSIKYVIEFVRNNLIDIAFSIVTTSSLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8P5</accession>
    <name>A0A0N5B8P5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8P5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8P5"/>
    <dbReference type="WBParaSite" id="SPAL_0000241800.1">
        <property type="protein sequence ID" value="SPAL_0000241800.1"/>
        <property type="gene ID" value="SPAL_0000241800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000241800.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37207" checksum="1BBCF0F6B396776D" modified="2015-12-09" version="1">MHGQIEAMDSAEIQWQKEHEEMHRKHANHDVMHAEILIIFIIALIFFQLILIWWKAKNFKSYQLVSLLGLWAIPFFVAITKYWYRFIFTWVIFTVFNIYLYRKTSQPHISGKIPRLVYKWFLFLHKMSYFLGVVGYLIMMLTLLGLNTIFSLKANDCLDAGILFLCYGLYYGVLIKDLAEITSEKMACKIGYFTSDGLPKKVLENNICAICGDKLNLTGQLLRTDKDFDDDNDAEAVHALSCQHLFHEYCLRGFVIVGKMATCPYCKEKINYSATFKNPWEKPHLLYGQFLDWVRYLVVWQPLIVLIVQGVTKFFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAF3</accession>
    <name>A0A0N5BAF3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BAF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000302300.1">
        <property type="protein sequence ID" value="SPAL_0000302300.1"/>
        <property type="gene ID" value="SPAL_0000302300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000302300.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50290" checksum="15ED677334898C69" modified="2015-12-09" version="1">MREVISVHIGQAGVQIGNACWELYCLEHGIQCDSTMPSDKSQGINDDSFTTFFAETGNGRYVPRAVMIDLEPTVIDEIRTGQYRQLFHPEQLITGKEDAANNYARGHYTIGKELIDLSLDKIRKVADNCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVEYGKKSKLEFSVYPAPQVSTAVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICRRNLSIERPSYSNLNRIISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATFAPVISAEKAYHEQLSVAEITNQVFEPGNQMVKCDPRNGKYMACCLLYRGDVVPKDVNAAIASIKTKKNIQFVDWCPTGFKVGINYQPPTVVPGGDLAKIPRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIDSGADEQEGIEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB16</accession>
    <name>A0A0N5BB16_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB16"/>
    <dbReference type="WBParaSite" id="SPAL_0000323000.1">
        <property type="protein sequence ID" value="SPAL_0000323000.1"/>
        <property type="gene ID" value="SPAL_0000323000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000323000.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25491" checksum="BE1DFC6BE7100564" modified="2015-12-09" version="1">MIFNIRYFSFAIIILKILLLFNNNAIYGLPLEKDTKLVENDNIEISKRDSDSVLVTVSEDEGEREKRRGGWKKEDRDVFRRHSRARNQDHRDSGRRRYERRGRHRDRRGHHHGHQGHHHCHHQHHHNRTTTTASETTTMPIVITTKTIETTAPATTQTTGIISTTQTTGIISTTQTTGTISTTQATGTISTTQTTGTISTTQATGTISTTQATGTISTTQTTGTISTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB54</accession>
    <name>A0A0N5BB54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB54"/>
    <dbReference type="STRING" id="174720.A0A0N5BB54"/>
    <dbReference type="WBParaSite" id="SPAL_0000326400.1">
        <property type="protein sequence ID" value="SPAL_0000326400.1"/>
        <property type="gene ID" value="SPAL_0000326400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000326400.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23809" checksum="63B62E4AC72186E9" modified="2015-12-09" version="1">MKSWKDLGEPSLDLLDTVEIKDVGANIILCLGALVIPVVLDNIEHTCKKKLENCAQVRVPNLSMSFDVSEDFKPCVMPFRKLKLNVHDLVKQRLEEECKLGYLRKIPSKQVSNASPIVVVPKSNDEIRICGDYTRINKFIIIPEAQDNISIKNILQLRKKNVRYLSSIDLKDAYKQFTIHGKNRELATINTPFGFYEPLRVVFGIASVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBE9</accession>
    <name>A0A0N5BBE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBE9"/>
    <dbReference type="STRING" id="174720.A0A0N5BBE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000335700.1">
        <property type="protein sequence ID" value="SPAL_0000335700.1"/>
        <property type="gene ID" value="SPAL_0000335700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000335700.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28593" checksum="2C50D2B82B6C536C" modified="2015-12-09" version="1">MNRFRYVILILGLFSYCCFISNILTLNFAVVCDANENETSLINYKPSEMNFLFSTIAIGNILGSLIVQYLFLNIGAKNTFCIYLGISLISTELIPIALKINYFFMLVIRFIQGISWAVSLPGMGTMTFSWAPLPESGIYLAILKTSGQLASLITMYLSSLLCSNNFGSSSIFYVHSLISLCLLIIYYVLYNDHPEDSKYVSTEEAKYIKHKKEGSERRGHSKEPVPYKKVFLNPTLTLGNITYFIYFLNMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCX9</accession>
    <name>A0A0N5BCX9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCX9"/>
    <dbReference type="STRING" id="174720.A0A0N5BCX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000387300.1">
        <property type="protein sequence ID" value="SPAL_0000387300.1"/>
        <property type="gene ID" value="SPAL_0000387300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF30">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000387300.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31596" checksum="414C680F4E48554F" modified="2015-12-09" version="1">MAISLFISLNKVAFEPTFNFNHAYELLQKWLDFFPYLAIGYVLLVFGGQKIMKKRDPFDLKYLVATWNLFFSVYSLISAYFLLPNILEIYKNEGVLPLYCKTGDYFTNQTTGYWSYLFVISKTYELGDTLFLVLRKKPVIFMHWYHHILTNFIAVLSYVRLTGWPRLSVFLNVSVHGIMYFYFAVTTLGIRSPTIVRKFITTIQLIQFAIAILFFTHLTKIILSGNKEGCDISEDSHFTGLLMFLSYFYLFGEFFYKSYIKPKKTIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDC9</accession>
    <name>A0A0N5BDC9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDC9"/>
    <dbReference type="WBParaSite" id="SPAL_0000401500.1">
        <property type="protein sequence ID" value="SPAL_0000401500.1"/>
        <property type="gene ID" value="SPAL_0000401500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000401500.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59259" checksum="207843B16173C8AC" modified="2015-12-09" version="1">MILKNYIKKGKKYFKRSVGEDETNWLSMLIASSLSFSAAVQYSVFFSSMWPFLTILDSNVTQSFFGYVVGAYSIGVMIFSPLFGYWSNRVGSIKYPLYAALISQLIGNIIYFNLENFSFGNKYWLFISRIFIGIGSSQTSLFKSYGAAASSKKDRTKALAIVTGGFSIGMTIGPAFNLMFTPIGYPGIRVFGININMYTLPGLVGVITNFVSIFIIFFLFKEHYAGVINKEEHYAGVINKEGKKTENYQNIPKADKIAIVIVNLTRFCQLLIISSLEAITSPLSLMIFGMTRLDSINACSVAHGFLGLNAFAVYFVYILFKLEKYFQFRNTIIVGICGLIFFHLSTYPYPFMSPVLVYNSTEYEDMKFFNETEPVGCDVDKFSWCNYMTMPVSPLYFFILYGSVIVGCDVDKFSWCNYMTMPVSPLYFFILYGSVIGISFPLINVSMNTLFSQILGPRRQGTQTGLVGFFGGLGQLVGPVIFTTLYSNYGPRVVWGSTIGMICVVLSSWIIFYRRMVSLKYETTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEN3</accession>
    <name>A0A0N5BEN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BEN3"/>
    <dbReference type="WBParaSite" id="SPAL_0000445700.1">
        <property type="protein sequence ID" value="SPAL_0000445700.1"/>
        <property type="gene ID" value="SPAL_0000445700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000445700.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10609" checksum="AA5A435143323626" modified="2015-12-09" version="1">XEMLEIGEKYKQERLKLMAEERLLHSLSVENVCNYLIHSEQYSAEILKEWCLRFIYLNAGNVFNSDEWKKVVTDHPLLVAKLFNIAVNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG11</accession>
    <name>A0A0N5BG11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG11"/>
    <dbReference type="STRING" id="174720.A0A0N5BG11"/>
    <dbReference type="WBParaSite" id="SPAL_0000491900.1">
        <property type="protein sequence ID" value="SPAL_0000491900.1"/>
        <property type="gene ID" value="SPAL_0000491900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000491900.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="62146" checksum="FAD3E5E386C45783" modified="2015-12-09" version="1">MQIVSAFPDPLPVEFNIDFSTFLDKVVRPYENIPLLFDPEANISYKFSELRFLVHRFIISFNKGGLKQQDVIASVINNSVEFIALFLACCKQRLIFCPLNTSYKTPELLSYLSKVNPVYLIVDQDFNKESSQILETIPSLKAIYQVENLMMGSPLINNENLYELTEFDNKTPALIMFSSGSTGVPKPVLISHRSLIYQINMFRSLKQNAIHDFLFLQPTDTTYGVLPYFHLGGLMVTLTMLIQSVKVVINKKFNEDIFYENIQKYQVTTLTIVPEILKIMCESEKIDNYDISSVKYIYYGSSKCNPSLVRKFKEKQPHVELFIQLYGSTEGGSAIFMMPKISEAHEKVNSVGVLLPGMQCKLVSIDDNESKNEVNVRECGELYLKSEMLMNGYLNSDESPIDENGWLRTGDIVSVDKEGFFYVEGRCKEIIKIRGWQVSPYELELAIVENFDNEIEECGVTLFKENDSNDCDEGSLVCLVVLKENKILNGEDVIKFVKDNFISYKHIQEPIKFVKCLPKTSNGKLLRHKLSELYNETSLIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG19</accession>
    <name>A0A0N5BG19_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BG19"/>
    <dbReference type="WBParaSite" id="SPAL_0000492700.1">
        <property type="protein sequence ID" value="SPAL_0000492700.1"/>
        <property type="gene ID" value="SPAL_0000492700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="252"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="421"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000492700.1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="156822" checksum="811EFAAA7B895E8A" modified="2015-12-09" version="1">MAPPDYKKFSSLEAFLKVAKARIQSLTEEEKKLEYVETSIPKDMLEKFCHALSEEDSDLEYSAESILTFVEELIKDGKDKEPLIYRCKDLFAIRLDANKDSANMDLLSRLVIGYRGILKTEKLALVQKLAMMRYLDLLPDRATDDFNRWVSNKIEPTYEEVVEFASNRDITFKRHKKTLMYKEKKMGEERGPFKKIAHNDEKAVKTITKSDHQKKENKKSTGVVEIVSMGNWCEKEDELPYATVVLNGNLVVKALLDSGASTNLIPKKLVEMLKDRGAVGELKVVNGRIKDVSGGMTDIYEEVELMMDIPGANVKEVSIIFKVMDCETAIIGRQFLREHKINAVDYEERIFGGLKIDISDIDVCGVLHDHPFLYKDKGVQKRKLEAFFSVKDMKPKRIIRRIKQSDREEVVQEIERQKSYGWLREAEDGENIENLNPLVIARKRSGKIRITQDLRYLNQFVSLDDETNIPSISTVMDIETDMLSFFDIRDAYHNCQIREDLQKWFAFEFEGKILISTVLPQGFKLSPYIWINAMHFITKPIEKYLIIYYDDVVNVAPSNIHHKINKKFLEILANYNIPISAEKCKLGTKRGIFLGYLLEAPIKISVPLERIQTLLNLKCPSTGKEIQETLGKIQYFARGVLGIAEKCNEFNKRRNDKNVNKKDLEEAWKSLMRSVAETISLRGIRNDCKELEIYIFCTGETINSTLKAKYENQPSEVVAVSGRRLKSYEQRYGKAEKILLAAKQILFANQILCCRFPIKIFSTVRGIEKAVNVEFGVANNTFSRLNTEISSFDKTFQYLKESLIKKEVLGEENFDEQVLEKEMEFVNTINYNERNNDLDKEELIRATALDNDALILKSYLDNKNLPQSKRMELPAHIRGKLEKMKKEHGCIFIEEKLFIPLELQGKLIQRLHQNHKSLFQIKKELNALYIGRGLLAKAESMVKNCEVCNRLQRNRNKKVTEWIKAEMPRERYHSDVGHYENHKFLLTIDAYTTYTTIVKIKSENIKHFKEAFSYTYSKMDCPMIQVVDNHRTLISNELNEYFSGLHVKLIKSIPEQHESNGLAERFIGMAKELLHKNNDKPITEAITIVNNILNSRIIDGNAVKDSFFGYRKSEGILDKYEKEIKVIGQSCWFKKKLDEREWSKGFCMERIGSNTFIIEEDGTDRIFVRRGDAVKLHNHRQGIKIKDEIEVANIMKERNITTLISVDGSTEKGKGCAVVIYGYKLPVACSAQTCEIKSLYYLIEVREKNIEHVAKEEQVMLMTDSDYAFRTLIFYLDSWKLNGWKTTKGKEIANKKEWEKIAEHVQEFSYLICKVKAHAGILANEEADLVAKRSAIHGDIVESEIFEGFMSNQKGMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGY3</accession>
    <name>A0A0N5BGY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGY3"/>
    <dbReference type="STRING" id="174720.A0A0N5BGY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000523400.1">
        <property type="protein sequence ID" value="SPAL_0000523400.1"/>
        <property type="gene ID" value="SPAL_0000523400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="286"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000523400.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45860" checksum="0DAAA8243D0DE0D7" modified="2015-12-09" version="1">MSAVIGPNPSSSTSSNGEAKPELLQKIEGQGSRVTAVHLLDKEDGVLSISDDRSVRIWLRRDTGQYWPSIVYYLSSTPICFYFDESSNELIVGLLNGSVSLMSITEDYNAINEKVCLQLHVNVVTGLAMSKKTQLVYSCSKDKTVVWSKIDNLQRCGSYIVSAQATALQYDDDFVFIGDSNATITILRILGESAQLISHLKGHSYPITALAWDVSRQQLFSASTDKLIIVWDIGGKRGQCYELNGHDHRITTLSFVDTSNKLLSTDCNGGLVCWDMSAKRMMTPEWRNSDKCDLCDVPFLWNVKVMWDRKVVGVRRHHCRTCGISVCGDCCNSTTTFPVMGFEKPTRICKTCNNRMKQFPEQYDLTPLAVSNDLKYGIISMHIHRDKKKMVTVGYDRVIMIWDISKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH99</accession>
    <name>A0A0N5BH99_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH99"/>
    <dbReference type="STRING" id="174720.A0A0N5BH99"/>
    <dbReference type="WBParaSite" id="SPAL_0000534300.1">
        <property type="protein sequence ID" value="SPAL_0000534300.1"/>
        <property type="gene ID" value="SPAL_0000534300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="93"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000534300.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45974" checksum="93ABB057D1ECE4FE" modified="2015-12-09" version="1">MTKIQGGDVVEIQGDEMTRIIWDLIKDKLILPYVDLNLHFYDLGIENRDITNDQVTIEAAEATKKYNVAVKCATITPDEARVEEFKLKQMWKSPNGTIRNILGGTVFREPIICKNIPRLVNTWTKPIIIGRHAHADQYKATDFVVPGAGKLEIKFVGDDGTEIKHEVFQFKGPGVSLSMYNTDKSIEDFAHSCMTYALDRKMPLYLSTKNTILKKYDGRFKDIFQEIYDSQYKTKFEGAGIWYEHRLIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYRQHQKGQETSTNPIASIFAWTRGLAHRAKLDNNEKLAKFASDLEAVCIETIEEGFMTKDLAICVKGLANVTRADYLNTFEFLDKLAENLNKKQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI03</accession>
    <name>A0A0N5BI03_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arsenite methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI03"/>
    <dbReference type="STRING" id="174720.A0A0N5BI03"/>
    <dbReference type="WBParaSite" id="SPAL_0000558800.1">
        <property type="protein sequence ID" value="SPAL_0000558800.1"/>
        <property type="gene ID" value="SPAL_0000558800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF1">
        <property type="entry name" value="RIKEN CDNA 2700097O09 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000558800.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38416" checksum="5A0214064B31B052" modified="2015-12-09" version="1">MTLNQVKSDFLNLLNKLDSNEKELFSEWVLSVLKKDVKYVSESLEPTNEISDEDILDSIASRLRDMVPVDATLTSENVIFQETGPDSDCKPNTTIHVDAFLYDDEFMEYMIEEGTIQPHYCVDCLSSNIQRKNFISHSLSTLQQRYIFNFLLPQFTSFENKIILDLGSRMGAVMYGANIYSGGKSKVIGIEMNKDWCKIQREIISSEKDLLKKNNDGIVDIEVVEGNILDYANILNSADIITMNNVFSFFNDKKEQKKLWKFVFQNLKSGALLVHNPKLDDEYFDHLNMDFNIYDVIEPLSFKSVLKKFSAGDKNIKADCNEIRIYKIKTPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BID1</accession>
    <name>A0A0N5BID1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylglutaconyl-CoA hydratase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BID1"/>
    <dbReference type="STRING" id="174720.A0A0N5BID1"/>
    <dbReference type="WBParaSite" id="SPAL_0000571500.1">
        <property type="protein sequence ID" value="SPAL_0000571500.1"/>
        <property type="gene ID" value="SPAL_0000571500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000571500.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31048" checksum="CC1377220FC7D6E2" modified="2015-12-09" version="1">MLKFIGQGFISRSVLKNVSIRTVAGGPNNPLIVERLQNEDKGIVLMKMTNPSTKNALSRLLVKQLIDNLDEIKFDKEARVVILKSDVPGAFCTGADLKERKLMPQDEVPKFVDKLRQMTVKFSSLPIPVIAVLDGYALGGGLEVALSCDLRIAGENAKMGLVETKLAIIPGAGGTQRLSRIVGPAKAKELILTAKIIDGKEGEKIGLVNCCVPNPDDKAMEMAKQILKTGPIASKLAKVAVDEGLEVSLNQGFTIEQQCYAQVIPTKDRLEALAAFAEKRNPIFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIR2</accession>
    <name>A0A0N5BIR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIR2"/>
    <dbReference type="STRING" id="174720.A0A0N5BIR2"/>
    <dbReference type="WBParaSite" id="SPAL_0000584200.1">
        <property type="protein sequence ID" value="SPAL_0000584200.1"/>
        <property type="gene ID" value="SPAL_0000584200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000584200.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="49032" checksum="135F051A48182A30" modified="2015-12-09" version="1">MEDISNKIESNAQFQFKIKNGEISIDCSKLINGDMEHIEYASKNYLTYKEEQLNMTCDAINSRGFGHATIRSRIERKYSLAYARNIYTSYEIIELILLAQYSKNNHYCYTVDSKHPELLEKMKQLEKCLPNVYVSENQYDFQSGGKYSSIGHFDCMKLLLNKRWNYMFILQNDDIAIKTNQQVLEILEAMDFPLDMAFHNQKKLIDSRFNHDYSWTYKDLNIFLEGDKRKENKSIINRNIEFHKGLVPCGMRYETVEYLAKKINITTFLNQLNTDLYGHDELTWQTLLADDILNIPGGISSKCIYIYHPRFAYLSRKVTWNSKDCATNMTHHLVCTWNVQILRLIGNYKGFHGYRFRGEQDFGAFKCWVNYMYHKNNFMVHENLNLWFYYNLQPSILQRKIMVKDLKSIESCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ47</accession>
    <name>A0A0N5BJ47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BJ47"/>
    <dbReference type="WBParaSite" id="SPAL_0000597200.1">
        <property type="protein sequence ID" value="SPAL_0000597200.1"/>
        <property type="gene ID" value="SPAL_0000597200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057772">
        <property type="entry name" value="SH3_Myo18a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24556">
        <property type="entry name" value="SH3_Myosin-XVIIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="218"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1664"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1402"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1576"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1664"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="313"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000597200.1"/>
        </source>
    </evidence>
    <sequence length="1690" mass="194977" checksum="52F674572A8267CC" modified="2015-12-09" version="1">MINNETLNSSQNSSFNFYGLQLPALDSVKASRRNVILSLSEINGYGFRWRRIQVPDKNSQWKLKQSVLLEPTDGCVGPPHVEEFHYKIYPGDILLAINNIDVREMNFRVLDNMLKNMNSDTIELIVENIPELADIKGFDDDSENVDNNDLNLTQSSLDATEYKNIPENNQFWLSHKNGYIMCELKERMENGRVRVLVGGKELVVDESDIDKANPHTINGINDVANLKYINDTTILHNIRQRLGAGLNYTDAGTRNLIAILKEDINSDNDLKRLIPKIKGVRRNDMPPHIYSKAQQVLRNIQSTGRSQGIVFTGGRGSGKSYQISCFIEYLINVGTWSKNFNPTIINDAICLLDIFGNSPSMFSVSSTNYVKLLSIPIENNGTMSGLKIETFLLDTEKLIASTNTLGTFHICSLFYNQMPNELRDQLFLDKIDKPKLLGGNNTNDIDSVFTWEKLQQVFLNTKFDESKKLGIYKILGAIFHLYQASATIGDCNRSNFVNVSNVEYAGKLLNVSVNDLYEVIFKGSLNNDKKPAVSSLMDRFKMSNKNQSGIDALGSFIKTLYQEMFNSIVGHINEVFTPKNSSTFITLLDYPGYNNHISLTNMDISSDLSDFINNYFNERILELSYDVHFKNAAEFYTSQEIDDVELNGPIISPSHITRLFDTRDTSSKTADIQARSNKKKGLIALVEEESMYPGGSDIGFVNRIHLHYDNSTIIRRGKDKKVFILSHLLDNFKTKYNADGWCRRVQPSKSANAVLPFLRLIVIKNEDFSNLFLPILRPNSDSNVQRMRRATQAINTESGNLKYGSGYFSSIVCQVDGVINCILRMSSIYMIHCIAPFIKTTFNNSRMNGNDKNYKPSMNDVMDVCFVRKQLKAIFILELVRGYNNSFPERMIYINFRRRFNCLLKDDGNYNDICDDRVCIRNLFTLINLPENVYRFGMSNLLLKSDVLNMLEEKRDTMLSSTMIEFQRMCKAYVYNIKRKENEVKESAISVIQKNYSKYKLTKNDPWIKLFYNVKPLLGVMQHEKQVTEEALKIKNLENENCSLKLSKIKLEERIAELEMQISMEMQNSDDIHKALQGVMDEKNVLEVALQEFKDIQKKSSSITESGINSTSPTPTEVVNNSIMEELNELRENELNYKITIKKLKAELDDVRRELDNVQSTNTMLVKKQESVNELEKKCQEKIENVLKEKENISKQRNDLNRNFEKQRSELQALKNENSELRLNNSKLRKDFDELKLSVASRSTNDLTSDNLQCKRELEKKVEELEDELEETCEKNDILNQNNNRLMLQIEKMKNQISREMEQRESEISDLRHQYNKRQKMFEEQIEDLNNSNKGLSNQNKLLEEKVRVLESEHSENEMRQSNYKFEYNNLLTLLRDKEALLAHERENSDSKKLLSKYKLLLEDAEHRITITKKTNVSLEMELADIKTQYENAISSKNTAENRNRQLKQDLASSEHEVTLLNEQVYKLTSQVKQLIEDKKEENILKNEMCETIQDLNSTIKRLQDEIQSMSSDINYHTKNCVDKHKYCIMELKVKELESKLELEHGLNQHLTAMNNLKCDEIEKYISLHESSKNTLDKERLDRKQLLEKISLLNEEISRFSKQDLDNKNKINNLELEISMMTATIQSVKSDLKLAENRANALNNVLESRIETFDDIEEEGEFDVNEDDINEVLDDDQISNSTKKKVTISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJV6</accession>
    <name>A0A0N5BJV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000622300.1">
        <property type="protein sequence ID" value="SPAL_0000622300.1"/>
        <property type="gene ID" value="SPAL_0000622300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000622300.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17928" checksum="733A01EAB519636D" modified="2015-12-09" version="1">MDSFSGEKETFPSYLQKINAYCRLSNIPDNQKLDTLIVHLRGRMMDLLMANENAKNTFAEAVNSGIFRHTYGWWYAINLLYARVLLYDGVYVYTKVFVKQKALRKLRSVGIKRSNPIVRLLEYSTTEVVGGERIALIVKDLEIIKRYTDVKGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJX7</accession>
    <name>A0A0N5BJX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJX7"/>
    <dbReference type="STRING" id="174720.A0A0N5BJX7"/>
    <dbReference type="WBParaSite" id="SPAL_0000624400.1">
        <property type="protein sequence ID" value="SPAL_0000624400.1"/>
        <property type="gene ID" value="SPAL_0000624400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000624400.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36958" checksum="3B510DD8DB6E3628" modified="2015-12-09" version="1">MLSLPQLVQLIYTIPLTIFYYYFTILLTYKIIIKKDSYFNNGFYPLILLKSYADLIDITNSFISIRFPRWDIASQFFLQITWLPYLFYMEICLTYNTMLFCSLLTSLNRFIAIKYPMKYNFWFSSRMLKIYFSIIISVGFILGCAVLTYHPYYQWSNGAQGYFVSFKNSNVGIFTVCYTFILYLPCAILAISLNVIAAFELKKYRRELSINMKKELPLFFYSIVSLVFFLLFFLYFLFRALHTIFYIPILQKIAIIAIPWIMDIQTFGLFYSSLIICKPLRHMVLFKEVDDNLVIQNKNLSKIKIISNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJY9</accession>
    <name>A0A0N5BJY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BJY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000625600.1">
        <property type="protein sequence ID" value="SPAL_0000625600.1"/>
        <property type="gene ID" value="SPAL_0000625600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="183"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="395"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="702"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000625600.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="124773" checksum="C6B72CADBE1AF52E" modified="2015-12-09" version="1">MTSQNKEQTEVFFTTNNNEVISSKEKNNFNIIRGKSFIIIIMIGGILFFIVGLLLINFGNEIFHPHAQYNDDPFNNVFQYLNKDKNRTSTGFLEPGLRKDNLNDIPSIYITHSPKNINLPIWRKNFISGNKSMPLYINSTSYTLSSIHTRSKGITLTPYLYEIFFQIYYDRILTEKNEPQYKYNSLVVNITIYLHCHKRTNIIKLNQKNLTLWDRSFKLEKISNGVNENIDLINVILNDPHETLEFVASKDLIPSNNYSLSLAYSVSLDHDDLAGLYKMTYRTNSSVDGIVLGTQLQAEFARRLFPCYDQPDMKAEFLISVRHPTSAKVISNSPPRLTETSGNGYETTYFYKTKKMSTYLLAVVVSFFRYKETMHNDIPIRIYTEPMKIDGVNLALETTKKLLKYYENYFDIKYPLPKLDIHTFPQMRVHAMENWGIITIRTDFLIYQKDVHTYKHRYETIKTISHETSHMWFGCLVTPTSWDLLWLNEGFATFMSFKGAEGIGSEKTLSDGLYYFDLQNACMDADQKFSNTHPIIPRVKNTKYIVKNKILYIKSALILFMIEEVIGEEIFRESLHQFIKENAYKNVNNQQLLETMEYVLEKRKGDNNLLPKNITLTKFVEDWILQEGFPLVTVTKNKDNSLHLVQEVMDSEHNINNRFANKWTIPIFIQDNVPENYSLKWIVTGENLTIHQYSLPLDPHCRGYYRIRYTDDIYDEFYHTLITNHTSISIPSRARLIDDAFTLAEFSYIDYSIPLKLIQYFTREKNYVPIAVFFKHFKNLKKIYGQESFFKQFTNYTNELLKCTYNYVNSKEFTNDESFVGFSLISDVTSYVCDNGDIECINESLKLFNNLKIICAQSRLSNSSCNTIPTYRKQIVYQAAARYGDKSAFDFLLRKYKEEDYATEKKIIRAALLCTKNEHLFLMFLKNSLFELDGMPLLGDLRQFVYDVYLFSSHGRIVRKLIMDKTYFEALYVKYKSIPVHFSYFFRFLNAYCDNDEQYEELKSFYQREDENVKQLGPAVMAEIKKNLVECQKRIKNRKSKNFKRLEEALFEIKKSYTIKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK92</accession>
    <name>A0A0N5BK92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK92"/>
    <dbReference type="STRING" id="174720.A0A0N5BK92"/>
    <dbReference type="WBParaSite" id="SPAL_0000635500.1">
        <property type="protein sequence ID" value="SPAL_0000635500.1"/>
        <property type="gene ID" value="SPAL_0000635500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF1">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894651" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000635500.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17537" checksum="5FF37A7C48F77875" modified="2015-12-09" version="1">MKFIVILLLTIATTFSLAKTECGTIESDYAPCIEKEKADRLFQNCCKMYAPEGCLPLCEYITDEFTSRSLIIEVLKSKKCSLKHISTVLFCASQNQDNRKCCEHLKLGDPTLGVGKRCLRFCDPSGEGIGALSKSDLTCIYNFNIPLYCGMSSIKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKI4</accession>
    <name>A0A0N5BKI4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sperm mitochondrial-associated cysteine-rich protein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKI4"/>
    <dbReference type="STRING" id="174720.A0A0N5BKI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000644100.1">
        <property type="protein sequence ID" value="SPAL_0000644100.1"/>
        <property type="gene ID" value="SPAL_0000644100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894733" evidence="3">
        <location>
            <begin position="18"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000644100.1"/>
        </source>
    </evidence>
    <sequence length="711" mass="79166" checksum="AE03F8574EBF6DB5" modified="2015-12-09" version="1">MLYLLLFVGYFIANTLAEDGFKNSVKWESHLKNGHIPPHSLMKHENQTIPLTLISTRKKRCSCGCNGCDLFPNRACCSPACCQGSAPLPLACCPPPPPPKPCCGPNYGPCCPATPQTTCCRAPCCEGRRPPIYEEEYEEPQPGFPVPSAPPSAGTCCPPVTPPVPPPPPPPPPPPPEPPIECCEEKPQPHVPQTCGCPNGNCGCGRPCCFYKDAQCCSSQKPCCPPVPDPLPCCAPIVLPQICCNIVPPCLRACPTCPCRKRVFLGKRSKRQSGVHCNACPAPGNVRASPKTGQSEFLSTIIEEPDSVANAPRAGKLFEASRHQRTKRNLCQACNNGIPIIKHRQKRSFDCVQCIYLKPRYDTTVNRPPFVGQGSLPQSPVPYPANPRDRVKRNGCLPYPGCLQVRRRSKRNWNSQYCEPCGGYHARKKRDAERDTCLREKYERDKQNGCKGSSAEFDEEEVEKENFRSKRQAYGKNGLLDLVKVLAKASTTHMVGPGGDTCLPFPQCVMAKRKRKKRSLSKLESYENALLNHRLKVMEHEEAVKRHKRQFYAPDQSANCVPCPAWVTLALAARKKRDVDNGVCEQTDDCLNDKEYKSFMKRFMRTTRKKRELKRPICRHCTGRETIHRTKRNFGGPTINASAHECTAFPACRTRKKRNFLDCNICTPDPGVKRRKKRMGDSAKCYPCPASEAASSQQVYQQPTARYVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLP3</accession>
    <name>A0A0N5BLP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BLP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000683800.1">
        <property type="protein sequence ID" value="SPAL_0000683800.1"/>
        <property type="gene ID" value="SPAL_0000683800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000683800.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20031" checksum="099BE82355C1D60D" modified="2015-12-09" version="1">DEAPKQFPKPKLFPKKVMVTVWWSSVGIIHYESMKPGETIDSKSYCQQIEKMHQKLSQKVPALVNRKRPILLHDNAKPHVSKRTVQKLRELWYETLSHPAYSPDISSTDYHFFKHLNTFLREKIFRNDEDTKTAFEAFIESGSPDFYVDGIIKLVFRWQQCTDCNGSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLR9</accession>
    <name>A0A0N5BLR9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5671 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLR9"/>
    <dbReference type="WBParaSite" id="SPAL_0000686500.1">
        <property type="protein sequence ID" value="SPAL_0000686500.1"/>
        <property type="gene ID" value="SPAL_0000686500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000686500.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33698" checksum="74D23D9E1D92AFC5" modified="2015-12-09" version="1">MILLYILLRWQTYFNSRVISAVAVVFSLAFGIYGLIIFFKGTIQFLDDNSDMTKEKDEMSNFYVQTDRFFKSGGVLIDMDTGETFKMQKPPHSNKSRFPDDVADRKIRVFPFCSQEYEFSIHYRQSFNIQVYLEINKKKYDLCVKDLTNEFEKRIITGVVFFLFGLLLTLTIIILNIKSMTNSCVNSNTNLGSAISSFLGVIGLAIGAIFITTSLSYFLEHVKLTSEEKTRAGLPEPKLNGKMTAGLVLLIVLHLVNIFINTVGAILRHKELKEIRERAFEIDFGKNRRSRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH2</accession>
    <name>A0A0N5BMH2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BMH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000711200.1">
        <property type="protein sequence ID" value="SPAL_0000711200.1"/>
        <property type="gene ID" value="SPAL_0000711200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="150"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711200.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49018" checksum="2882FFB01D503DCB" modified="2015-12-09" version="1">XQYVKGKDNAVADYLSRNDFLSITIKEEAFKDVFPDMVTPYDKPYIIENMKHHLSDEEAKKAKDGIFTLKKGGIRVYVPSLLREKLLKRFHNSVTLGNHLSLAKIGPKFKEIFYWESMNSDMNKIWTACDICNASKDHVGRLVETTKRHLPSAPGNWAILNADYMQVDDENILVIVDEYSKFAYAVVTKNQNGPTTRLQLSRCFTTLGFPLILRSDNGPAFISKAVQEYTTSIGVEQQFGSPYNHKSNACVERFNRTIREAIRVERLIAKQEKRNPMKLSDIAYHFTYAYNRSKHLTTGIAPATLLLNIPDNLTNNVSIHNGYSGILQLYKNTKTELKDNDTRRKGIQIKANDLVMKKINSRKDTSTSNKNQPTWDGPYNNHKSNACVERFNRTLREAIRVERLIAKQEKRNSMKLSDIVYHFNLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN54</accession>
    <name>A0A0N5BN54_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Metazoan SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Penta-phosphate guanosine-3'-pyrophosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">ppGpp hydrolyzing enzyme involved in starvation response.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESH1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN54"/>
    <dbReference type="STRING" id="174720.A0A0N5BN54"/>
    <dbReference type="WBParaSite" id="SPAL_0000733300.1">
        <property type="protein sequence ID" value="SPAL_0000733300.1"/>
        <property type="gene ID" value="SPAL_0000733300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="6">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000733300.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25230" checksum="84ACAF2932390BD9" modified="2015-12-09" version="1">MIGQTLRKLSQINLGRLPSCIRFINISSLPEFCVIPTAHQREIQKAVDFTEKYLKDRQHSISGETYTSHAVDVARTLFTDGDVYTPKVLIAAILHDVLQDNKVTKEQIVEEFGDEIAKIVEECTVYTSQSKSHEQDDQKLIANSTNNSLEARLVLFADRLTNLKHLEQIDPEKWKERDVINYYRRSYRLIHKCKDTNEKLEEKIRKICTEKFKTLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN98</accession>
    <name>A0A0N5BN98_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN98"/>
    <dbReference type="STRING" id="174720.A0A0N5BN98"/>
    <dbReference type="WBParaSite" id="SPAL_0000737700.1">
        <property type="protein sequence ID" value="SPAL_0000737700.1"/>
        <property type="gene ID" value="SPAL_0000737700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000044">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="197"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="225"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000737700.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="75900" checksum="F7FF2CA69822B183" modified="2015-12-09" version="1">MEVEKIAILDFGSQYGKIIDRKVRECNVMSEILPMTTTFKEIEKAGYRGIIISGGPDSVYAKDAPICDIEIFEGKLPVLGICYGFQLLNKYFNGKVVKESIRSDGQLSITIDNTYSLFNSLSNEEIVLLTHGDSVIESSLSSDFHVIAKNHQFIVGIKHKVKNLYGLQFHPEVDLTVNGHKILDNFLKLVCNLTGNFTMEAREKVCINEIRRIVGDEQKVLVMVSGGVDSTVCAALLNEALGRDRVVAVHIDHGFMRLNESQKVIKSLENIGVKVHFYEAYEKFINGTIDDCNGKKMKLCEIVDPELKRQIIGNTFIHVKDDVMKDLNLDSNIFYAQGTLRPDLIESASSLVSGRADKIKTHHNDTELVRELRKLGKVVEPLKDFHKDEVRALGVTLGLPNHLIQRHPFPGPGLAIRIICADKPFDEGHFKSTNDMLQNIMSLGKCTKTELNNNYKSIVELIHHRDLEVLLNSMCLNFKAILLPIRTVGVQGDSRTYSYVVALSSDTNDIPWAFLKSLAKIIPNIIQRINRVVYAFGKSFDSTDITDITPTYLTQENIKNLEIADDIVTNVLLGLNEDGSPSSEIKPSIHTIQQMPVIQIPIHFDRPNCNSQPSTKHSYVLRPFITNDFMTGIAGIPPLFSEDALLEMNRRILKNVSDASRVLLDLTSKPPGTTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNE9</accession>
    <name>A0A0N5BNE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000742800.1">
        <property type="protein sequence ID" value="SPAL_0000742800.1"/>
        <property type="gene ID" value="SPAL_0000742800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894579" evidence="1">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000742800.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24414" checksum="E58861029A9DA284" modified="2015-12-09" version="1">MKSKNIFCILTFLYIFNCNNAASPPNVLTCDKAKLPQSWLWTEGHGILDVGTAGMIPDGPDYCIDFNRTSTFVQIQYHIDLLNVSSNIINIKKDITTRENYSNNSCINQDDRIHYCFPLCSNSTLQDIATKNALLYRSAREAATNIYKDMYDDGDNYVVTVIKVSLDTKNPARLLQDVFLNPSYCSVYIGMQTIGLPYLYEIEIAKIYNSKNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP27</accession>
    <name>A0A0N5BP27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP27"/>
    <dbReference type="STRING" id="174720.A0A0N5BP27"/>
    <dbReference type="WBParaSite" id="SPAL_0000765500.1">
        <property type="protein sequence ID" value="SPAL_0000765500.1"/>
        <property type="gene ID" value="SPAL_0000765500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="69"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="300"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000765500.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58649" checksum="C88AA2DF87445ACF" modified="2015-12-09" version="1">MVRKLFDISLSTMCRTYVNGDLALLPENCKQRLIEFFCSHDQFFHDDCAKLISSPYFGSNLTEVNFYLSDQVDDLLLENLVQMNNHLTKISITLCPNITDKGILSLTAKQPLLECLELRCLQNLTSDGLKNVKSQNLFIVDLSGCRKVTSDGIFHLVYNNPNITKFYLNDCRSIDDQALYDIAHGIGDNLQVLELNFLQNMEDPAKSLLNLSQRCPHISQLSLCRFFEFSDDENEQECTIEGMELREVDLYGNYFLKLPNLPLSLTKLSLSVSGEENASNLVSKLLNLPYLETIHLQLNCEEMSNAAVEKCNGFLRTFIGGLGKKIINLHISCNRIVDEVLLLITNNIPNMTHLALNVKHINSYHLQRYFGTSNRAIIFKLRSLKLCRLKISYRALFAIARNAKCLEEFEASHMLCVDDRFLLILAQNCRFLRTINFNGCRWVTDKGLSALARNCKLTEVRIRATSCTDKSIYLLAQFCPEIEWIAYSDYSGRPKFSDKALQCLKNACVQRVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPC7</accession>
    <name>A0A0N5BPC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000775300.1">
        <property type="protein sequence ID" value="SPAL_0000775300.1"/>
        <property type="gene ID" value="SPAL_0000775300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM2" evidence="4">
        <location>
            <begin position="393"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="310"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000775300.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58852" checksum="B8826E74692FAE6D" modified="2015-12-09" version="1">MSNVNIIKLDKPQIIRTSFKNPTAPKLRECIDPFLTLAKHYLFEGNFEKAEELVKFFLPALKEEVIIEIPDVILRLFITKNVSEYRKINYGISEEEDDLLFDFLNCATDDNAFRSGKKFDLPELPRLLPKHFTKAHPNAPEIALNFLKQVNLFNYGKTRNSGFKFVLDDFVKGLDTNENEGGNNFFDGLVVIVSKISKAYRNKRFKLYCREEDVTNLFLSRDTVIKFMTAIFNSEANETGILTTTLDDKEFSDELHRIAGLLNAGDFVDFSLGEKLSTLELLFTLVVEMGLFSETCEKIKLDSRISHRSLKDKLREKQKLEEQINKLSSEISLFEDGIVDPSGAKMTRQLVSEKRKELRELKLALEEVDEAYQEMEYKKNGADYISWNRSPHTLGRDRDFNIYKLSTGFDFIYVMKPKNAKYSFSGEKYAKTYKPNCSVNDELISKLSPVMEMKCDGYRYFYVSSVEKLEELISLFDNRGVREKELLRNLEKIKNIAKLHIETYQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPW8</accession>
    <name>A0A0N5BPW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPW8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000794300.1">
        <property type="protein sequence ID" value="SPAL_0000794300.1"/>
        <property type="gene ID" value="SPAL_0000794300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000794300.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8788" checksum="24567E7E2BE4EC80" modified="2015-12-09" version="1">MSSSNKKNNNDEDIQDDYLIQSMIRNQHLSRENIASSQEDLRVMKASQAIICRNKGDEFVCNKLRRTSVPDFKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQS9</accession>
    <name>A0A0N5BQS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQS9"/>
    <dbReference type="WBParaSite" id="SPAL_0000824100.1">
        <property type="protein sequence ID" value="SPAL_0000824100.1"/>
        <property type="gene ID" value="SPAL_0000824100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF9">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000824100.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38147" checksum="08EC5C0F15631EB3" modified="2015-12-09" version="1">MFTEDNVIKSNNFENNPLVRDEKKPLLVFILNKYALNMTFNFLCNTKYIEGVHEQILIIALDVEAKEKLIEKYPNLHVLLLNIPCLHRPFNYGDGYYQSFYVLRAKLSLELLNHGYSFYMAQQDTFWRDSLLKIKLPPDADITFDSASSKVNLIAGGHYFTHPTEKSKNFFSTLSTDLSKFYAPDNAYMTLLCYRKIAKCDFIKINLITNWIWLFDNKLREEFKDPMLIQFDGHTELGGKLDFMKKLGFYFMKDNGMVCDRGVVEGRMKGLSKFNGGGELFNLMSFRQFSFYQNLIEIFYSNWIMEFIMNEIIFPYSFYFMISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR59</accession>
    <name>A0A0N5BR59_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR59"/>
    <dbReference type="STRING" id="174720.A0A0N5BR59"/>
    <dbReference type="WBParaSite" id="SPAL_0000836300.1">
        <property type="protein sequence ID" value="SPAL_0000836300.1"/>
        <property type="gene ID" value="SPAL_0000836300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF19">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000836300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16209" checksum="B4DC1935B63C7968" modified="2015-12-09" version="1">MENFLLKLKPFDKITFPKPIPGNVTSESRLLIKNNGHERVAVKIKCTNNKMFKISPVFSSADVGEARLIRLIFITENDVPMDGKHHFSIHVVPSPESETVCEAFNSEKGKNPLTIRIPIFFEKKFKRSNTEEKITYLYNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR62</accession>
    <name>A0A0N5BR62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR62"/>
    <dbReference type="WBParaSite" id="SPAL_0000836600.1">
        <property type="protein sequence ID" value="SPAL_0000836600.1"/>
        <property type="gene ID" value="SPAL_0000836600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894813" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000836600.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19286" checksum="17418F59BA32AFB8" modified="2015-12-09" version="1">MKFFISFLCLLGFINFSYSLKASSDSVAEIIRDKLLNEMETKLDRMKKIQILKDKFKDVNPNMEMGNYTQYVLTKPFVELGIKKNLRDVRALVSQIEEKLLPYLTQDFDKSKRPKRSSNVAAQPGLDKAASEAFCRTWDKEKFKRCKSIDFPDRRKIIAIPYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRJ4</accession>
    <name>A0A0N5BRJ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyltransferase-like protein 17, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRJ4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRJ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000849300.1">
        <property type="protein sequence ID" value="SPAL_0000849300.1"/>
        <property type="gene ID" value="SPAL_0000849300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000849300.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58116" checksum="559978A4605C3781" modified="2015-12-09" version="1">MVGVSNIATVTGINVVTKAKSVLRLSQNPSLQRIKTPRQPKLPNAAIEGLKAALTQCKRPPKQLQSEADNLYERYTQRHFPASREVIRATRSFVTMKLREAGMEELDASVYGKSINKGSKEYFNAKVAKALKQLNHTWKPLDFESEENAAAYALALLSSNFSEVYRVLCEFDTNKFVPETVLDFGSGIGSSFWACNEKFGPSVKEYTLVDSNQIISQFAMDIMRSDKGGEVLVHPNVNFRRSFVPSLQTKYDLVICHRSLIEFPNPDIRLELIKALWERTNKYLIFIESHMFDSFEAIIEARDYILEGAYTIDLKKAEPIIKEYGVTHYEINEILNNNKLSEFEKFCQIKSKFPDNVKLPTTLEPSHVFAPCPHDKSCPKLDMTVGKKNSCNFAVKYRDIRADGKKTKLENGTGNTSYSYVILEKGPRPKGQEFYPRLVKYTKGNKHYNCHGCTAFHGIQHYVISAKNKSLFQLTKGLNHGDKIPYKIEVEKTLSDDAILTEEEIFNLQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRM4</accession>
    <name>A0A0N5BRM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000852100.1">
        <property type="protein sequence ID" value="SPAL_0000852100.1"/>
        <property type="gene ID" value="SPAL_0000852100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894778" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000852100.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10968" checksum="19226F9785998C6E" modified="2015-12-09" version="1">MRVFKTLTLFIVILISKCVKIYAVRKTLKIYGAPQCLPQFTRPPVADNTEVKVTAIVGSSDGSQVYSQLTKTLPCDELITIEPYFRDKEIDKKSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS24</accession>
    <name>A0A0N5BS24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histone-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS24"/>
    <dbReference type="STRING" id="174720.A0A0N5BS24"/>
    <dbReference type="WBParaSite" id="SPAL_0000867000.1">
        <property type="protein sequence ID" value="SPAL_0000867000.1"/>
        <property type="gene ID" value="SPAL_0000867000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="240"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000867000.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46728" checksum="599E0E180834FDF1" modified="2015-12-09" version="1">MEDSSDEDEYFQEYYDEEFFEDLGTVTATDKILFVIGRNEDRTKYLVVTDDYGDNTPMSDYIKVYKVTKDIDELMKAKINRLNDRHCIISALARQNPDVPLRMNPFAPTNDDDFDIMVKCMYLSWSYYFTTTKSFRGNKVFIVNYVDDEWPQFVYENRSMSAEEGKFKNVPKIKGCTDCDSTPHENGCTEVKKWFIGIFGDLLDKDAYLPFFECSNDCSCFRQTKTICKKRISCLNRDRIPLVIFKTADKGWALAAGKDMEAGKLVTEYVGVIHDDDETSIRSDSTYTFNMDYMREPLEEKYGPNLKRDYRFYLIDSKRFGNESRFANHSCDPNMEVIVSFGTYKCPTYHKVFYFTKKKVPMGSELTVKYFHTPGTDVTNAVKCHCGSVNCMKFLPIVQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSF6</accession>
    <name>A0A0N5BSF6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSF6"/>
    <dbReference type="STRING" id="174720.A0A0N5BSF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000879900.1">
        <property type="protein sequence ID" value="SPAL_0000879900.1"/>
        <property type="gene ID" value="SPAL_0000879900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF8">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011327850" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="36"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000879900.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="68257" checksum="51F0381B765C2B6A" modified="2015-12-09" version="1">MSFFNANSIYYRSFISNMRWRLLLLVSFLVATGSASSYDEYDDDAFEFLAHDPHPTKPDTFASICMNATGGVYMTRRRICERQIALGSYKNAVNSTGWGFLEIETFPGYSYELQNYAAGYLEGVLTKLQIYYHYRNTIEGMCKNYRNYCKQLWLYLTENLDWLRSQATKKATTDKYWRHVNLTFTQLTGIYDGYIGRDPKELEANVRYDMTPILMIQLSGELFDLNKFFKKQPDPVRDDPDPGKCSGLVKVTDGNKDLLFSHVAMSSYSTMNRVMKLYKFGYDKKDIPGHTVSFSGYAGALSSADDYTLMSSGLAAIETTIAIFNETLYTDKYIKPVGQIHCWVRSYIANALASTAKEWTDIFAEYNSGTYNNQWTVVAYKEFKPNQELPKENLLWVLEQVPGYTMAKDMTWFLNKYKYWPSYNIPYFHEISVRSNFIEKGKQNNWWKWGASPRAKIFHRDQGKVKDIDSLKDLMRYNDYKHDKFSRCGCNPPYTAEAAISARGDLNPINGTYEVEGMGHRNHGSLDYKGTSYELFKKLQIHVIGGPTWGKVPPFDWRTTDIVSPHYGQPDLWKFDPVITEWDTQVEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTF1</accession>
    <name>A0A0N5BTF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FABP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTF1"/>
    <dbReference type="STRING" id="174720.A0A0N5BTF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000913300.1">
        <property type="protein sequence ID" value="SPAL_0000913300.1"/>
        <property type="gene ID" value="SPAL_0000913300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000913300.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17212" checksum="F6E0BF8EC828BD62" modified="2015-12-09" version="1">MGLNEKQKKLVGKWRLVKNSDNFGEYLDAIEIGMLKKTLALSISPDIVINVDPNDSSKWNCSVVSPFKNKTWNYTLDTKEKMDTVDDRVFYVTVTLTEDGEMIEKQEVVPDEPKVEIPSIITRYVNDEGHLVAKCEAKNVVAYRYYTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTU3</accession>
    <name>A0A0N5BTU3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000926800.1">
        <property type="protein sequence ID" value="SPAL_0000926800.1"/>
        <property type="gene ID" value="SPAL_0000926800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895150" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000926800.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15420" checksum="216EC28E359981D4" modified="2015-12-09" version="1">MMQLYFFSFFMLVLSNSVVPFLLCHNNCYSFENNNKYPEHWCDKFNLPVSGRCQTTSTEGCIKGHIEISDKVIYFQTCKNKSPVNFGFSQDGNCTEYSNSGEDNVLYFPIKNATRASMKFRACKCFSNLCNSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU67</accession>
    <name>A0A0N5BU67_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis protein NOP53</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU67"/>
    <dbReference type="WBParaSite" id="SPAL_0000938775.1">
        <property type="protein sequence ID" value="SPAL_0000938775.1"/>
        <property type="gene ID" value="SPAL_0000938775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938775.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10199" checksum="8DAA8E6108CE5965" modified="2015-12-09" version="1">LKTKVKFNSSSSRTLTTSLGKIKKTEVPERKKMKMISDAKWRRNKFKVLEASEQIEVYEGRNDKILQSNLVNQITRTVEKENMKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUS4</accession>
    <name>A0A0N5BUS4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUS4"/>
    <dbReference type="STRING" id="174720.A0A0N5BUS4"/>
    <dbReference type="WBParaSite" id="SPAL_0000959300.1">
        <property type="protein sequence ID" value="SPAL_0000959300.1"/>
        <property type="gene ID" value="SPAL_0000959300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="190"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000959300.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32196" checksum="B31B2B6238961382" modified="2015-12-09" version="1">MKAKTSKDTLSLPIMEDTKKENNNVLNSPNNQIATQVNMPQRPMETNMICGNVNEVSFNLRQPPTEDPDSTKYRMGNRTSYQSSSNAPHNNMRSVGRMPYRSSIYSFKNRFRNYFGRDYNPIDRPCDVIFEEDRENAEYYNNLDEIIVSRAGNAPKCYETWRDANFHPTLQNTITKSGYTKPRRIQAFTIPIIANGFDLICQSEAASGKTGAYLLPIIDEMLKSEWKSKNEPKTPYAMIIAPTRKLVIQISEYGRKLCEGTKLCCATLYGQKTKDFFKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV74</accession>
    <name>A0A0N5BV74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV74"/>
    <dbReference type="WBParaSite" id="SPAL_0000973900.1">
        <property type="protein sequence ID" value="SPAL_0000973900.1"/>
        <property type="gene ID" value="SPAL_0000973900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7381" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="189"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000973900.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38445" checksum="0C09094335007EB1" modified="2015-12-09" version="1">MDFLEYISENHPELRHKQIVLIITGHFDQFGFFKSDNKPQVYKTCLPQPHQKRSSIIKKKTKFSKDGILVRYSIKGRPSYKCNGRTVPSLKHLAQCTLKQRQIKFGPTCSRGFYKDEAPVCVKDILPEEKSLDDIFCEKPNTIYMAEFQKSLKYNTFSSKTWFSIWENRLSFMCFSRDNFYLLKSRFLKELNIYRIAHNAPPLIENLKMTEKAQLRAKALANFKKISPDPNKEYEEVIGSSEIFMAPFMIKRWYDECNRYNFRLPILTRKSKNFVKLIWKNSMYIGIGVVKSQCHIIVVLKFTRRKSKFTGYLSNVQKRIIKNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVQ5</accession>
    <name>A0A0N5BVQ5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVQ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BVQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000991100.2">
        <property type="protein sequence ID" value="SPAL_0000991100.2"/>
        <property type="gene ID" value="SPAL_0000991100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="163"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000991100.2"/>
        </source>
    </evidence>
    <sequence length="483" mass="55474" checksum="DA63563EAAF2C368" modified="2015-12-09" version="1">MVTLNNENDIEERNLHTTINVQNSTNHNTCGKRKHIFDLLINNKVCMVCINLVRWFPVVLVFGIVGWAYYAYVVILCFGVIDNLFKRIVFLIILHILTGLFMWSYLATVFTENGKIPEEFYLPYEVNEDVKNAGSNDIAKEIVRRYVKMHNLPIQNRLYDQAYRYCHQCSLVKPDRAHHCSICRKCILKFDHHCPWVNNCVMYSNYKYFILFLGYGLVLCFFVALSNLDTIIFFIKGISSHSGTLNSVGTSFQLIFLEFISIMFGISLSCLFFFHIYLISKNRSTLESYKAPVFTFGVDKNAYNISLKHNFAEVFGKKPFYWFLPINSTSGDGIVFLYNGSGTAIYAHEEATISLNNITNNSTIRVIDNHSENTLQTMGDTSNFGLKNENDTRINKNGSGIVYRTSTFTLSSKFKRINTESLSTSDEEEEEKSNYDNCLLEYDNSMGEADIKDYNSQLENGNKLRFTIRSGVQYSSISQSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVU4</accession>
    <name>A0A0N5BVU4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPATCH1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVU4"/>
    <dbReference type="STRING" id="174720.A0A0N5BVU4"/>
    <dbReference type="WBParaSite" id="SPAL_0000995000.4">
        <property type="protein sequence ID" value="SPAL_0000995000.4"/>
        <property type="gene ID" value="SPAL_0000995000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000995000.4"/>
        </source>
    </evidence>
    <sequence length="870" mass="100696" checksum="550CFFE8874F710E" modified="2015-12-09" version="1">MSDIMEDGDSPNITLAPKIAKTETGYDIVENDGKVGEPQRSVEGWIIFITNVNEEAQNEEVLDEFERFGTVKNIHLNLDRRTGYLKGYCLLEYETQSEAEEAIREMNGKEFLGQIINVDWAMMSKKDYVLYGHPVEIIEDEDNVGINKRAKKPYEEIVTDEKGRQRFHGAFTGGFSAGYFNTVGSKHGWVPSTFTSTKNKRTNFEGQKREDFMDDEDLGEFGIVSSRLKLKSDYNPINKDKRQPKFVANSLEFHLEGMLSLKNDINMGVNILKSMGWKFGQGIGGKMSRKNLEKMRVLERQKNGFDIEKVKEFDKFAPEFKFAPDDVTFPNVEIKKNRQGVGYKGLASNHPTSYGGEKKITSQISGNNVVFRGYAFGVGAFEQEDEDIYGMPDMSEYDFELTSKKDKKQNFSSNDAEFIKIEDTQKPRKSYYSDKVPYDFDCKHKPFKFDYNLLPENILKLKNEMSFDDKKTIFAEGEYKINNLPQKSLEKKESTEIKDALANCYPNNPMKRYRYNQFVNYTKKGILFPMPVGMSKSEYEEEINEFKQLLPGEMLDKYERLKQGVKPLAQYDYIEKMKEMVSNKFVKAGDAERDVSEPDTQKNSMLPAREIVRTVQEWHPAHVLCKLFNVKDPFPGSDIVGLLFNPNNFKHDSKDEWKKIKDNVSNVKSTVEFEGPSETNEQILEIHTNNIMDEELLKVKRDILLAIFDNIEKDDIQDNVERASEDFTSSFPSKSNVPNPETDEKVSTKPTVLYNDKNNISEILKGYEKIKDGKDCSMKKEDKRRKNKSKSKDNISHEKHHSRRSRSTSREKTKHRKRERKKHRHSKSPDSTKYDKKSKKKKRRRSPSSNSSSDEILSRVVNDYLDKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVW5</accession>
    <name>A0A0N5BVW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVW5"/>
    <dbReference type="STRING" id="174720.A0A0N5BVW5"/>
    <dbReference type="WBParaSite" id="SPAL_0000997100.1">
        <property type="protein sequence ID" value="SPAL_0000997100.1"/>
        <property type="gene ID" value="SPAL_0000997100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748:SF1">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000997100.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35982" checksum="3B2DEA352D280A7F" modified="2015-12-09" version="1">MVDVLDCFILIFQLLSSILYTSVAVFFATKISKKDKDGMNSFYIAFIIGFIIDQIELLKTIIFVTIPSFGFFTTFYRDNPIPRYTIGTLGYVCTFASLLGSFSLSLNRLIAILFPFFYKLRWSKHSILINIIIQIILPVIVFHHKYGKMDRLVLDKNTQKWVYSSENSETSKYNNLVATSFSTSILIVQISINCFNLCKLLIYKKKESNYLNYRANLSLAIYCTLGTLGNSTICLRYWIKFVGSFQENVSLKNFGQTLGTWTSVITTTSEPYLMLIFNSSMRKDFFNFYLRRKTSVTIISSNNIKPKVSRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW93</accession>
    <name>A0A0N5BW93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW93"/>
    <dbReference type="STRING" id="174720.A0A0N5BW93"/>
    <dbReference type="WBParaSite" id="SPAL_0001009600.1">
        <property type="protein sequence ID" value="SPAL_0001009600.1"/>
        <property type="gene ID" value="SPAL_0001009600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001009600.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="35229" checksum="D2FC74A85082E1A6" modified="2015-12-09" version="1">MWRSFQTSMTLLSPDVTFFLGDIFDEGQWSNKEGFERYISRFDELFRVTKNTARYVVVGNHDIGFHDYIHPQRESWFGKTYPNSTPVGVIELKNEIFVLVNSMAMHGDYCRLCHMAEMEIEKISNKLKNGIKQPRVSNGKEFIKKQKQPTVLMHFPLYRNNDMNCEGGNELNDFDIRKSEVFREKWDCLSKNATQFIVDRLNPKVVFSGHTHYGCKIKYDNFTEYTVASFSWRNNPMPSFLLVIYDNGDVKVNICFIPHENIVIFTYIFSVLLIVIYLFYVYYKRNFVNPNFSNIKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA3</accession>
    <name>A0A0N5BWA3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidative stress-responsive protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA3"/>
    <dbReference type="WBParaSite" id="SPAL_0001010400.1">
        <property type="protein sequence ID" value="SPAL_0001010400.1"/>
        <property type="gene ID" value="SPAL_0001010400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010400.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24609" checksum="04373576BD81FB5A" modified="2015-12-09" version="1">MNDKYKKKLEFKQIRDEKYEKEEMLIKVNETIISLNSLSVQPSTVKSKGSSEDKKNSDRARSLKRFSPYQSPRNYCLNEDIDDSLNRGRSNSFHCKYDDAKFISNKNCFRNRRHTLGSLDSLCSDEEKSPDTNNTNLISINPNETIFDNSSNTNSLKNGVNNIANNSCSFEMCKKPKYSEDADFIGEMDELSDYFNHFVGVEMKMSSLAESMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA8</accession>
    <name>A0A0N5BWA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T9SS type A sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA8"/>
    <dbReference type="STRING" id="174720.A0A0N5BWA8"/>
    <dbReference type="WBParaSite" id="SPAL_0001010800.1">
        <property type="protein sequence ID" value="SPAL_0001010800.1"/>
        <property type="gene ID" value="SPAL_0001010800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058265">
        <property type="entry name" value="DUF7959"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058830">
        <property type="entry name" value="LolA-like_dom_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25899">
        <property type="entry name" value="DUF7959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25897">
        <property type="entry name" value="LolA_1st_nematode"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895027" evidence="2">
        <location>
            <begin position="21"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="LolA-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="LolA-like" evidence="4">
        <location>
            <begin position="251"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7959" evidence="5">
        <location>
            <begin position="475"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010800.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="74458" checksum="F7C3B5629945E728" modified="2015-12-09" version="1">MRRIPIILTLFLIYSVLLNAYEIFCNHPNLPYNSNVTDKLILPVNYTVVTRITNFKNNETFKVIERNYTNVATWTLHSTNGLKKWILGEYSDFSIDNYTMKNENCEKLQSYQNIEVYGLSESIKKTFNITIDSINEIIQKLTHYSYDTSSLLENSRVINGVDSITWMGCKNITNNGYKVQVLIAHSGERTQQKPYDSYFSNPVPYEVSIIEYTDINKDNKSEVEIKSNVVLSIVELEKSSEKIKYDDILPPRMSFCKGFPNVTLPSNIPSDFEARYKIYNNVDNKVSNIAIFYNKKYQISSYILEDNFDFVVPFVGKFKGKDKYKKVQIIQDFTYGYEYILSTEYGTCLDVRGLSTDFINTGILNNLIYLKGPKDFMLTPLGNNFYYYGLIRTNMNQTFASYVSNNLNNGTIEVLYLNNDWEIPEFSGQILHTINYKSLDLNFKLELISFKNTTEESFSSINYDVSPCLEITSNSYYYIKIKNATTKVVQNLGLQNVYDGLSYVLSNTSQITSPLRFTNHFVRESGGDVMIFFSISKKLDISPSKTINFRNQTSIDEIITTFNKTLTLSEISFKIHNTILTIRQNSLMKVPKIIPDPDPSKFVGYTAASLFVSAFFSFAFGVLLGIGGIVFQWKKHRLSNLSYQIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWP4</accession>
    <name>A0A0N5BWP4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWP4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWP4"/>
    <dbReference type="WBParaSite" id="SPAL_0001023500.1">
        <property type="protein sequence ID" value="SPAL_0001023500.1"/>
        <property type="gene ID" value="SPAL_0001023500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="14">
        <location>
            <begin position="188"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001023500.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="42328" checksum="FA2EC8CE9741CAC4" modified="2015-12-09" version="1">MTTRRYNPLLDSWVIVAADRLKRPWSGEKEVKYDSVSLDNHKDISIDIPINNNPLAPGGIRDNGKRNPMYSGVYVFENDFPTFNKDKQNIINNHSEKDDLFVEENLLSGICKVICYSEKTNDRLSVMSIDQIFNVLDTWCDEFEKLKFEFDWIQIFENRGTEVGSSNMHPHCQLWAMNYVPSIPLKKDETQKIYFEKNGKNMLYEYMKKEIEKKERIISENDDWVVLVPYWALWPFETMILPKFNIQYITELSDSQKRSLAIILKIILLKYDLIFDCSFPYMFGVINAPSGKYFNKSKPHWQLHFHFYPPLLRSSTIKKHLAGFEVFAEPQRDLTPETAADIIKKQQNKEIEDLLKYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWY7</accession>
    <name>A0A0N5BWY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWY7"/>
    <dbReference type="WBParaSite" id="SPAL_0001032600.1">
        <property type="protein sequence ID" value="SPAL_0001032600.1"/>
        <property type="gene ID" value="SPAL_0001032600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894966" evidence="1">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001032600.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31426" checksum="811D8B7A7D4C40F6" modified="2015-12-09" version="1">MKLHIFFSILNVYHVYSRFCSDSKKGVCEVDDLGGWCYHNITSNEYNCDEQNFCGNKENLKGRTNFGGCYKSGDSEESSECCCNKGELCNLAMMVAQREGNNDLQKCYFAKEKSDEETIVYKECVEPYCLIFMEKDMIGGLSRVFHGCESKSMYKYKTLKDNNEADGNSSDWKEFESIAQNPRCIEMLNYVEENENGTKIACIDANFMDNGVEKKSKYCCCKGSDFCNENISWSYPTISLQVPIHDRNSSFKLLITSSSFVFTLIAFIQGCYLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWY8</accession>
    <name>A0A0N5BWY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWY8"/>
    <dbReference type="WBParaSite" id="SPAL_0001032700.1">
        <property type="protein sequence ID" value="SPAL_0001032700.1"/>
        <property type="gene ID" value="SPAL_0001032700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001032700.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43186" checksum="F7E128CE74BE7B0D" modified="2015-12-09" version="1">MHAQLNQLFRRLDLRRKTRKFERKRKNLSGSLSSISTQTSGFASMGSIESLSEQVLPNCLLFKILDYNDNVYDLVKLREVSREFKTYIDNRMSYYHFMDVKKGNINSIIGSSYTYGNWYFNNSKSLALRISRRSKVISKKNINCIPHFLEVIVDDQWSSTDVNRLLSLLRFFRKYPKQLILDAPIAELMVVSLSSIDVNRWYAFQCFMKITNDFEMRMSIINVNKRRQSVPINSLISIPNNNKLSNDKEITTNYNKNVFWPSVSIFTIRIFEKQEGHLLRLIDYNVKMDKFFDKDRLDKLKVEINEEPIDFPKLSVSSEISVYSHTSSNSLSSHTFSSNSLKRGVFNFRCWAGSCGFDSQFCQVIMSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWZ7</accession>
    <name>A0A0N5BWZ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWZ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001033500.1">
        <property type="protein sequence ID" value="SPAL_0001033500.1"/>
        <property type="gene ID" value="SPAL_0001033500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF4">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001033500.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38785" checksum="7C47C338FE18BA65" modified="2015-12-09" version="1">MNLEQEKFYSSVYVNVELISIEWRKECSINNRCTQQRFQLNSNIFGSHEFQRIDYSVYSKYTTKPIFLHSYYENFHPYDLIISSKVIGYDEFFQIPIDCDESTPVFAYKNLQQSGENNEALLVLVGKCYTAHVSVKYYVDKKCLKCEDNEIKITSSALSLKNYFGTNYNNLVIILITLIIIFSLSSIILIMLIIFHCRKIVKYRRMRRLIYPISPLAVTKDDKIFETEKKIKNEEDLVDKSIIISKNYSDIQNEVFYVNYQTNEVLNEYNTSTKLEKMESVSDWIVSKNNGTTYLSDYESYKQNISNNIDDDNLSTASTSLFGGVCGSNPGVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX07</accession>
    <name>A0A0N5BX07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX07"/>
    <dbReference type="STRING" id="174720.A0A0N5BX07"/>
    <dbReference type="WBParaSite" id="SPAL_0001034500.1">
        <property type="protein sequence ID" value="SPAL_0001034500.1"/>
        <property type="gene ID" value="SPAL_0001034500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001034500.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="72279" checksum="715B79A4694E467B" modified="2015-12-09" version="1">MIKSNEVAMKDSVRHRQILALKQLLNLNTPTISTLSSEPVWKVIVIDKYGQDIISPLLSVKQLRELGVTLHLLIHNKREPLPDVPAVYFISPTEENISLVCEDLKTAMYDSFYINMIYPMSRIQLENLASAAVHGGTMQQVQKLTDQYLNFIALEDDFIILRRFKENSSISYHAMNDPNISVQQMDALIDEIAKSLFSICVTMGVIPIIRCGKDNAAEQVAIKLDQKIRDCLRDARNNLFVQDSFKPGQMKFQRPILIIADRGLDLATMLHHTWTYQALIHDVLDFDLNRIVMIDKTGKKKDYEMCSIGDSLWKKHRGSAFPLVAEAIQEDLETYRKNEDEIKRLKHVMGIDNVESDDAAMILGNTTSKLQSAVESLPELLEKKRLIDLHTNVATTVLDIIKERKLDTLFENEEKILNRQAGDVNIKELMNNCSDPTDALRLCLINYLCSTTISDSELKEQTDILKQRNISLDAIAFAKRIRSFSNMNKMGEMHQGAGTKTVSMFSKLLNQSSKFVMEGVKNLVPKKHNLPLTQMVDNIIDTRPSVTGVSTADSDEYRYFDPKVMNTASKDMLKPKSGQLAQDVIVFQIGGGNYVEYQNLVEYAKTKGVERITYGCTELVTPKQFIEQMEKLGSKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX86</accession>
    <name>A0A0N5BX86_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="STRING" id="174720.A0A0N5BX86"/>
    <dbReference type="WBParaSite" id="SPAL_0001041900.1">
        <property type="protein sequence ID" value="SPAL_0001041900.1"/>
        <property type="gene ID" value="SPAL_0001041900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="799"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1640"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="1956"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001041900.1"/>
        </source>
    </evidence>
    <sequence length="1988" mass="230015" checksum="ADCE60F81F64654A" modified="2015-12-09" version="1">MSNDKKVQIATVKCCSAILRPFVDAFADKHMKYKREVMKTIKLILNALIKVAVSHTERKVRQCVLNCFLSTNDNFLYQLAHEQRVKTLALTLNDQDSDTRNASVALFAKLSQINPGMVYSRLRTVLMDNLSLLEYSTDSKTDIACGIVIAEIAERAPAFIKPYIDYVIKMIVRKLKVPNIEVDVLVALLNALAALCLIGGIDVVKNFEIVFPELVNFLSEGYSLGKRSGALKAMTYFCQSTAYVIDPYRDYPSLLPALFRHLKMEASANLRRQILKSLGTLGAIDPYMYKVFTGEISSTVSKTINITKPVPKLDGQQHYIITWMNYEKCTLDEFYPSVAIAAALHQLSDESQGNFRQEGAVALQHIFEFINESNVLPLETFVPQVIPKLIEVIGECQSTRTLTKFIESLGNIVAQCRKLVSPYTNDIFYLLRDVWGRELKTDKNHTLRGAVVEAIGKFGIAIGKHFTNYVNDLAPFFTEIIQIDMTSNKGLTKKALICIQQLSETLEPTIHLILPNILSILDKSSGSVGERYPKDVRKEALKTLITLAEKKALRECATMVIQAWLRNVDDTSFLSNIDDSYTNRIRELFMILLLLLARQLWVNFDCFRSSVEEKLDNIQINKEWRSRYNQLMKEIEIYQKGIERNRSGSIREPLRRSDTLMTLRNSVSSTRGGKLSENETTDPHWLYKLFKIDMRQTREEWLTWLDLFKLQFMKYSPSPAFRACHSIAYCNPALAKELFNGAFVAVWDKLSGDTQTDFLNFLVQVLKNSNEPEIILTILNLREFIDHCGKISVGLDKTLLRETADSVKAYAKALRYKELEIRNDLIKNNLEWSVDIYNVMISYGNKLNCTELALGMTEHARKRGIRVSGIWHEKLLQWEEALKCYGEEVKNITDEDEIRKNSMRQMRCYEALSQWQEVDNIRKKVFTVENIVQKPTPLNDKVACIAARCLWTLGSGEMDDYIKIINENTIEGSFLRAVSEFKHEKYDKTLEWVQKTRDMLDSQLATLAAESYERAYPIMLQVQQLTELEEAVEFKLRKHRRDQITVCWSRRFQGCKINLEDWQKLLLIRSLVLSEDEMFPMLVKYANLCRTEGKHSTSRKLLYGMCRDSKSTAVHRIEDLVLPLDKPPVVLSLLKTWKYDYSQLKDVEKKKEMQNRMLKISSDLTRYLEAEKDQSNCLKDVIVKNLAKTYVMSGDWISEHLAKPKIFDSYNFVESVWIPSMDSNFEDFRKTVQESIRYYGKALEYRPNWYKAAHKFAETNYLLFHDLYVEYKSRQQADNNKAGIDTSTEYSKRSSPQLRPPNFNLQQQNYTKPIYRHSEGVLHQYNNNLLSSNQKVLHTNNEMEDQHPQHQQPSPIKNIKTDLFLKMCCDQYKKVVSAYAIAINASDGSCLQDLMRYLIIISRLEDMTHVKYDNIWNEVNKVQADAWCEVIPQLISKLDKESTTSAAANFLEIIKNILIKIGRDHPQAIIYPLVAASKSRNKIQILEHALIINTELTRVAVLWPEQFHDSLEEASKCWFQDNNFIAMKNVLEPLHKQIQQDITTLTQKEQSFVYNYKIDLDNAWSNCLHYENTKQVKHMHAAWDLYYNTFKKLTNQLRNMQTLDMKICSPDLIAYRNFNVVVPGTYNPYSSKDPVMIKEVKRFANVISSKQRPRKVIMIGSDGEEYCFLLKGHEDPRQDERVMQLFGLINTLFNKDRRTYRRNLDIQRYSIIALNETCGLIGWLPNCDTLHSLIKDFRDKGKINISAEHTAMQSYVIDLEKCNLMMKVEAFKNALTATSGEDLRQTLWLKSPNSEIWFERRTNYTRSMAVMSMVGYLIGLGDRHPSNLMLDRLSGKIVHIDFGDLFEIATMREKYPEKIPFRLTRIMVRAMEVTGIEGNYRNTCERVLNLCRTYDDRLLAILEAFVYDPVIGNKLQSGSKAVNKQYTPPKVIPHTGTAEIERIKHKLIGRDFTFWHSYEVEGQVNRLIEEATSADNLCQCYVGWCPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXV0</accession>
    <name>A0A0N5BXV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4373 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXV0"/>
    <dbReference type="WBParaSite" id="SPAL_0001061633.1">
        <property type="protein sequence ID" value="SPAL_0001061633.1"/>
        <property type="gene ID" value="SPAL_0001061633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001061633.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11586" checksum="3A9FD6127B587ECD" modified="2015-12-09" version="1">MDRTQLGCRIGWEDLVIFMILEGSIYFTIILLLRGVWQNAGAAVCLNDYGQLIQSGKGYRLSVGKTLHLAEKLHNENVRNSLQSVTEKYKNPNDPESYGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0A0</accession>
    <name>A0A0N5C0A0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0A0"/>
    <dbReference type="WBParaSite" id="SPAL_0001142900.1">
        <property type="protein sequence ID" value="SPAL_0001142900.1"/>
        <property type="gene ID" value="SPAL_0001142900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001142900.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43789" checksum="869D93B47E7F0059" modified="2015-12-09" version="1">MESNLLFNIDRNIILKSDWDQWEETIKNKMKEELDEWSKIFAEKHLKTKEKITEIEQNKNDIIKSCTIEKKDPTEFLNAPAYAYNKTYILYELYKLENKYRQHYLKVMYDQLLNEFVKLKTNVVGNSVDNNQLIDQNVPMDISTKFNINDSVICRKKRKCVTIEPIKKVNTVSYTKSKCDILHQGLQKYDCYIEIGFQIISFARTCKEFAVNAFHDEIIITLKDQNDNEKKISFEAAKNNSMELTCIKDNLMTKYFLRLLIVGIEESIKRKKKDKRMNILVGGLRKCDITLLTQIENGTTLEKNLDNDEITILAKYMKYSNSACKIAFLENCTSTYIRKIAKNACYQITLNKNNYSKESYAYDDIECSSDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0V4</accession>
    <name>A0A0N5C0V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0V4"/>
    <dbReference type="WBParaSite" id="SPAL_0001163300.1">
        <property type="protein sequence ID" value="SPAL_0001163300.1"/>
        <property type="gene ID" value="SPAL_0001163300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895215" evidence="2">
        <location>
            <begin position="19"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001163300.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="79625" checksum="C5A5A503DCD8589F" modified="2015-12-09" version="1">MFCHITLLILPFILSIGSLEDSNFNLIFNILHYGSNFDGLGDEIKTSDRNYNLSLSEFTDINITTNNMDRIKVEKKKVYHIKYDKVSLPLSTNETLYGFTMDFSNKSSLKLLGRLSNFDIKHNESDNNITCQWHKCNVGIYFFHHDDVDKFDINNRSKEFNIDYLILFVIVPNDNKLYLDTVFYYGEVFLYHGCPVYNYIENNVNIEYFVDEEILRNEVVLPKYNKSYIFLPIFPRRNGETFFKCGYIKQPNVSTIDIGFYLKESYKVVEKLTNNNFGYTVKQRCPQLKSEYFHSYEYLHNNSSGVYERQLRRIKDNNYISSGNRVYYFNMENFNYSELFELKKFKPQKPYSVCIEDYADIKDRFIPILEKLNDIKEDSKTGILYQIIKPSIFNKTFEPKCIKKFDDGNDRNIINYRLDVIRNSNTAFDNQSIKNLIFTVNSIETYGGYFCALTPEYKISNSSNFKKQITYFIPENGTIFTLPNSQIRNLAEFSPPFAGYLEDYTTLTKISFFNITKNNEKLLLYKLTINGSKNINEELSPYVKNVLVLCEYITKVGTKISIVQHFLKHNSLKHQNELLKSNLGTKNYTKMTNSSRNSEENQWENSYNWQNAIIIIVLVLIIMSILVFFIFLAIRKANSQHMKNTSVNRKVHNREKTYLELKALLNKNDIPNFIPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1G9</accession>
    <name>A0A0N5C1G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CSD_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1G9"/>
    <dbReference type="STRING" id="174720.A0A0N5C1G9"/>
    <dbReference type="WBParaSite" id="SPAL_0001184400.1">
        <property type="protein sequence ID" value="SPAL_0001184400.1"/>
        <property type="gene ID" value="SPAL_0001184400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000274">
        <property type="entry name" value="Mitochondrial RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001184400.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28463" checksum="8C7488AD64D3FB3A" modified="2015-12-09" version="1">MTVKTETSKSAEGEKTTTPTSDPKQQVPEEPKNKKDESKSEVLNDENHINGQVVISRGLSGRVKWFNVVNGYGFINIDDDKGDIFVHHTAIIKNNPNKHLSSLADGEEVKFDVVSGRKGPEAANVTGPNDAPVKGSVHADYPHKLRRQMRANKKFYKKLKTGDDNKVTEKKYENSSDNAFENREKKTRQSNNGNRKFSKKREGESGQRPEGKSQYQNNEQRSSQNNGPKRGGSFGRGRRNGLRRGPTNLGPQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1K0</accession>
    <name>A0A0N5C1K0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein ubi-d4</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the requiem/DPF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1K0"/>
    <dbReference type="STRING" id="174720.A0A0N5C1K0"/>
    <dbReference type="WBParaSite" id="SPAL_0001187400.1">
        <property type="protein sequence ID" value="SPAL_0001187400.1"/>
        <property type="gene ID" value="SPAL_0001187400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001187400.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40297" checksum="11E19F2C5E3FBCE9" modified="2015-12-09" version="1">MSTNMISESAYSDCIKKCMQWNRRMQMQRRQSGPVIDQQTGIILKPTRLHRTITHRFHPDGPGKVCTYASRSWIKCDKPSADYIELRYFIKSNRSIGDVISTSNAVVTSTISTENSLPESPAMNQRQLQSMKYEETTEFEELPEEEVEELSDDDEYASKKKKGRGRGRGPRKSVGGPGNNLMNTPKQEPMDTTTSIGSTPEKRFICQACGAKYKSRPGLNYHKQHIHPDVDNVADPSIPDPVINISTTCDFCGGNKRRNKKTGKAEVLVSCHDCGRSCHPSCCGFTENMFTSFKKFGWQCLECKSCAICGTSDNDDKLLFCDDCDHGFHMYCLKPPLEKAPESDWSCDLCKNEYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1P9</accession>
    <name>A0A0N5C1P9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1P9"/>
    <dbReference type="STRING" id="174720.A0A0N5C1P9"/>
    <dbReference type="WBParaSite" id="SPAL_0001192100.1">
        <property type="protein sequence ID" value="SPAL_0001192100.1"/>
        <property type="gene ID" value="SPAL_0001192100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF13">
        <property type="entry name" value="INVERTEBRATE-TYPE LYSOZYME 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895208" description="lysozyme" evidence="11">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="76"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001192100.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15684" checksum="2E483791572DDD5F" modified="2015-12-09" version="1">MLLKFLLLTILLGFTYSDRCLQCIAKQESGCRRVGCKMDRGSLSCGYYQIKHSYYQDCGEPGRLPGESSEDAWKRCSDRYHCAASCVENYFKKYKPWCQGKSDCEAMARLHSGGPSGCYGSSTDGYWERVRQCVRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Z1</accession>
    <name>A0A0N5C1Z1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Z1"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Z1"/>
    <dbReference type="ESTHER" id="strea-a0a0n5c1z1">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001200900.1">
        <property type="protein sequence ID" value="SPAL_0001200900.1"/>
        <property type="gene ID" value="SPAL_0001200900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895213" evidence="6">
        <location>
            <begin position="17"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001200900.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="69378" checksum="8473724773ABCF55" modified="2015-12-09" version="1">MKYFILLLSIISLILCGKSKDKNKSKDKLVETPFGKILGKKITIKKEEVSEFLGIPYAYPPIGAYRFKRPIPLKEPAWKDTFNAIHKATACPQIIKLLNFKDYDELLPHNGTIESCLKLNMWVPKGKNLPVLVVLHDGFYSIRTASVDRYYGAYLALKSKSIVITFNFRLGFFGFAYLGGGQIIPGNMGLLDQQMALKWIRTAIESFGGNKNSITLIGFGSGGSSVSAHLFSDSSCGLFNRAIMSSGTITNPLNTMLPRYSELNTRRVALRLDCKGDDRQILACLQERPTMRILRAAQDVFQPVNYPIPYKFLPVTIDNLFFKGNLTEKIRRNKFNKNVDLMIGITPDEASLLMATELVTNSSSYNCNFFPSLPLSDKRNLCNMNATSFKEVVRLARIMLDLIPSEAKELFELYNDIPGLTYTQKSVRLLSDVLFNCEIYKFAVIYSEASSSNVYFYENRKRFSLSKWPSWTGVLQGDEINYIFAHPFRHPNRYNKKNLKDEQKYSEALISLIREFSKSGHPSNKGKKFKGPQETRALILDNKLDLKKLKTEYVLPLCPKVNRIIINARRRLQSGGPGTAPPSPTTTTTQATTTTKKKGILSKVKNWFKKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C268</accession>
    <name>A0A0N5C268_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C268"/>
    <dbReference type="STRING" id="174720.A0A0N5C268"/>
    <dbReference type="WBParaSite" id="SPAL_0001208100.1">
        <property type="protein sequence ID" value="SPAL_0001208100.1"/>
        <property type="gene ID" value="SPAL_0001208100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001208100.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54481" checksum="7C30C2657D7A1408" modified="2015-12-09" version="1">MNDGILYGGSRDQNSVFTDYDNLNSNSGVSNQEGIIFMNRFLRPNSIDTLQDVGEVGDSSVTLSSPLGSQISHQTKASSPTLSQDGNSLDLTFTSRPVLSHSHRKRYFSSDVNLTSDISYSKPQIKISKFSDHSFKDVVFKSDFLNKFLKKMPDEKLIHHVSEENVDAYRDAGYDIRITQKSGSFNARSITTNKNYKVIPLSSKAMSQFTAVATRLNEMKFCDKFSPSEYEEMKEMILPEGTILLDLPFTGTKSLLMPISNIEGEVSLYEYIQDRQATLSENDVRPIFKSICKLVQFCHEIGIVLRHMQLKKFEFTNDSCTKIRLTDPLELYVCKDFDDDFIGERHACPAYVAPEIFRRDKEYRGKQADMWSLGVLLYVMLTFRYPFFDKDVKGIFSKIIAGKYSIPGNVKVSSSSFQIITTLLRMRPEERLTIDDILQSKWLRINSKCLPKTPCLISTDIPCTPVVEVNASSTSSSTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2J2</accession>
    <name>A0A0N5C2J2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2J2"/>
    <dbReference type="WBParaSite" id="SPAL_0001220000.1">
        <property type="protein sequence ID" value="SPAL_0001220000.1"/>
        <property type="gene ID" value="SPAL_0001220000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001220000.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34437" checksum="4FC829672CB6B7AF" modified="2015-12-09" version="1">MPLIDVGYQCDEYNDDPINHFVNKDSKPYFLSIKNTELMCQDHIIYQSSPAGIALLTRGNNYNDVNEFRIRHLTKDTNLYAGDRLHILDSVKNQFAYMEDFTGYVVNYEAKCKLPNIKATLRLKVNGTVQKFKNNLDKKFGKIDTYVVDRREIKDIPIGCHAVPDEMKQPAFNNFYELLYSTSLLMFNETTQHYIEVNNTQSLISKTKYKCILNIKSRNSKIEKPDYIKETDFVINVIYEKTNKSTSFYNSTVAKISTISNGSTGSNNSTVAKISTILMALLVLITLQLPKSLLSLMALQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C388</accession>
    <name>A0A0N5C388_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C388"/>
    <dbReference type="STRING" id="174720.A0A0N5C388"/>
    <dbReference type="WBParaSite" id="SPAL_0001244300.1">
        <property type="protein sequence ID" value="SPAL_0001244300.1"/>
        <property type="gene ID" value="SPAL_0001244300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="150"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001244300.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42642" checksum="F4764084C2A22F41" modified="2015-12-09" version="1">MGLITMIREYDLFAKPLDDFRIKTSFGGIISVLSFLTIAILFITETISFIHVKTKESLFIDYTPGDTNVTIYFDIAFHKLPCDFLSVDILDQGGQSQENIIDNVYKMRLDSDGNLKANSEMVKLVVNNNHTIIPNLNSTTPLPPNYCGSCYGASTGCCNTCDEVREAYQLRGWSIQNLDNIEQCKNDPIIKLFTEREGEGCRVTGRAMVAKSGGNFHIAPGEGQSFRKTHMHVLKGISIDRFNISHTINHLSFGEGFPDKKLPLNNKVFIDENGGIMHSYYAKIVPISYTYVSNKYEVFSYQFSATHVKKDILKAQSGLPGFFFIYEFSPIMVRYEEYYESFGRYAVNLCAIIGGVYTVAALVDSFAYKSIRILKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4M6</accession>
    <name>A0A0N5C4M6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4M6"/>
    <dbReference type="STRING" id="174720.A0A0N5C4M6"/>
    <dbReference type="WBParaSite" id="SPAL_0001290600.1">
        <property type="protein sequence ID" value="SPAL_0001290600.1"/>
        <property type="gene ID" value="SPAL_0001290600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895399" evidence="4">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="37"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001290600.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23603" checksum="3F2E1B80E067DBB4" modified="2015-12-09" version="1">MISWYCVLSLILQLAYFLKSFRLNTNHGCIDAHPTEVHPDVTEFLGVPFALPPMGPLRFKPPKILTHDYYNYAGHCFNAMYPAKACLFKKKAVEFVGIDEWQPKNSEIHENCLRLNMWVPKNKTGGVIVFFNGRSYHSCFGPLPQYDATILSHKTGLIVVNVNYIDGTLGFAHLKRKKFVPGNIGLLDQQMALNGFMRISNILVVNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5B9</accession>
    <name>A0A0N5C5B9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5B9"/>
    <dbReference type="WBParaSite" id="SPAL_0001314800.1">
        <property type="protein sequence ID" value="SPAL_0001314800.1"/>
        <property type="gene ID" value="SPAL_0001314800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001314800.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15183" checksum="C37217DB6DEB097B" modified="2015-12-09" version="1">MIKKEKQILSRNDSTLTTDSVQSTGSTKSMPNEDNFDNINGNEDNSKVITNHNLKKFLGIIGKTRSEADFFNGKPSKTVIRTFQQQNIVKLPSLECDMETQNRINHYKEMEASFDKLVIDTMGGSRKLDYEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C600</accession>
    <name>A0A0N5C600_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C600"/>
    <dbReference type="WBParaSite" id="SPAL_0001337600.1">
        <property type="protein sequence ID" value="SPAL_0001337600.1"/>
        <property type="gene ID" value="SPAL_0001337600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001337600.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22568" checksum="4B94550659516FDB" modified="2015-12-09" version="1">XVTSKIDFRPIYLYEFKLGQTAAKTSRKINEVFGQGSTNKRTVQRWFQKFRNGDTSLQRRKGSRGVSVLENEKLKRMVERNPRITVRELAGELGVSIGTVFNHLKELNMKKKMDSIIPHELTPDKCLRRMETCCSLIPRNKNDPFLNRIVTCDEKWIMFDNRRRSSQWVDKNGSPKNFPKLKNSNKKLLLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C621</accession>
    <name>A0A0N5C621_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C621"/>
    <dbReference type="STRING" id="174720.A0A0N5C621"/>
    <dbReference type="WBParaSite" id="SPAL_0001339600.1">
        <property type="protein sequence ID" value="SPAL_0001339600.1"/>
        <property type="gene ID" value="SPAL_0001339600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001339600.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35673" checksum="610CD476E508F4FE" modified="2015-12-09" version="1">MNVPQSMAYAQLAKLPTVIGLYTSFLPTLIYAILGTSKHISLGMFAVVSLMVGTAQQGYYLNNNLSYDNITNIVGGELDPKSLGLLTPIQVTVTITFFCGLTMLIMSIFQLHILTVYLSDELVGGFTTGAACHVSLSQFTKLFDVHTKSHSGLFKFFKIAIDFFSHITKTNFAALIISVACLIVLYVGKEYINPKIKKRISYSIPFELFVVIITILLSYFFEFNKKYNVKIVADIPTGFPKPTVPKFPAFSSLIVDSMTIAIVIYAITYSCGRIFGKKHNYTVDAKQELRALAIPEIIAYFISCHPTSGAFSRSTINSQMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C627</accession>
    <name>A0A0N5C627_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C627"/>
    <dbReference type="STRING" id="174720.A0A0N5C627"/>
    <dbReference type="WBParaSite" id="SPAL_0001340200.1">
        <property type="protein sequence ID" value="SPAL_0001340200.1"/>
        <property type="gene ID" value="SPAL_0001340200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340200.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19556" checksum="F485D70E452C36D1" modified="2015-12-09" version="1">MNRNYPNTEIVGNVVVFGGRGSPLSNFYKSVFADKENRMYYSVEQYFQYRKALYFKDFVMADKIKEAKTPVEAKRLGGRVKNFDEKKWDDVKFDIMLEELTLKFQSLPFKSILEDYYIDTSTLIRRVFLENTGNMYWGGSINITTGRIQGKNYLGKLLNKLASQLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6F4</accession>
    <name>A0A0N5C6F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6F4"/>
    <dbReference type="WBParaSite" id="SPAL_0001352300.1">
        <property type="protein sequence ID" value="SPAL_0001352300.1"/>
        <property type="gene ID" value="SPAL_0001352300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001352300.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27119" checksum="CBD168A1C349F58D" modified="2015-12-09" version="1">MSVQTNVPSAEYLAFLEEGNGKNQQDKTVNSNPPKDKDKEKDPDKGNSPKKVNPPPSSKEGKNKKRKAFSLIEEYAKQLELDNRTPESFMLLKTLDCMPSKSLSYCFIMSIGFFQLYYRLNNSDKISDWRAKLDLKGNTQLDVPHYINYGVVSKNNSMLKIYNEDPPKHLRGVVFQITDGVNFPSMRIPNCKELLIIYRGGPIVGCLPPKLEFLGLERFKDSININWKLLLTGLNNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6X4</accession>
    <name>A0A0N5C6X4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6X4"/>
    <dbReference type="STRING" id="174720.A0A0N5C6X4"/>
    <dbReference type="WBParaSite" id="SPAL_0001368900.1">
        <property type="protein sequence ID" value="SPAL_0001368900.1"/>
        <property type="gene ID" value="SPAL_0001368900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001368900.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27578" checksum="0876D3F81F20C8D6" modified="2015-12-09" version="1">MTAWKTWQLTNICMLIKPTESMSRHEMVKKENVNGKVQFLCNNVYPDNVPTIGIIESKGLQERGKDKFLSKLASKAAERKGDPMITDLYAEASDFLCELKKLQTKDLHEKMLVKEAEKSMQMSMENDIINKATYEEVEAETKRREKEREKIQEEKEFYERKRLESLNKPKTLGAVGEGEMITCIDGQSRMFYIQKREGDEVISTRRKVTSNHVKEFTVVDQVSQVYVSEWTFQWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Z7</accession>
    <name>A0A0N5C6Z7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6Z7"/>
    <dbReference type="STRING" id="174720.A0A0N5C6Z7"/>
    <dbReference type="WBParaSite" id="SPAL_0001371200.1">
        <property type="protein sequence ID" value="SPAL_0001371200.1"/>
        <property type="gene ID" value="SPAL_0001371200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001371200.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36323" checksum="E364805E662F520A" modified="2015-12-09" version="1">MGAKDGSLDETLEHILKEIPSITTYILEDKSTISFKCTNNRHFDELVEVACYNLRDYTISKFLLPYDINFQNLEYIIIFLAVKKVFVIGEDLKVVQDIFKKLESVLLKTEVPIKLLEDQETQDVRGVRDTIAKKASNSEVITQLSNAMAMVVNLYILLKNMDIINDLSAQAALLCYTSGSVTASLRIYDYMQYITAPVAIWCIGQACSMGSLLLVAGAKDMRTELANSSTMVHQPSGGVQGTASDILISDKEIKYLGTRLNEIYIHHTGQPRKVISECFDRDYFMSVHEVLEFGLVEKVEPHNEITPSLGRNKTKRVSLNTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7D7</accession>
    <name>A0A0N5C7D7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRESAN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7D7"/>
    <dbReference type="WBParaSite" id="SPAL_0001385100.1">
        <property type="protein sequence ID" value="SPAL_0001385100.1"/>
        <property type="gene ID" value="SPAL_0001385100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001385100.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15573" checksum="2A607FE682597AEB" modified="2015-12-09" version="1">MVYVVNEKKRKYYEEEVDGNDKKRSCNGYEVLSKLTELVENIGTSNYIPQIKNCLDENYKIPSKKKCTKIFNPYMSNTMIINYAINNDLYINDNSFSPTKNIYCHNLSSGTFVYQFSMVRLLQWMMRTSNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7N1</accession>
    <name>A0A0N5C7N1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7N1"/>
    <dbReference type="STRING" id="174720.A0A0N5C7N1"/>
    <dbReference type="WBParaSite" id="SPAL_0001394300.1">
        <property type="protein sequence ID" value="SPAL_0001394300.1"/>
        <property type="gene ID" value="SPAL_0001394300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="80"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001394300.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="48394" checksum="0E73F68AA634A3BF" modified="2015-12-09" version="1">MDGSINGAWGELPELPYIGDYEPDVNTPQRDVPSDAFVDAFKKKLKNKSIKIKQFLDEHSDNLYLYVEQLKKFASSPGGLISDEYREKIWPVLARSYPSDFDYIKNSEDSESDSDYDTVSSTLDAEYDEDYIEPTIEMLQLHKDWKQVQLDVHRTLERFPPFIDQEKRNVLMEELTPFIVKVLYRNRKFHYYQGFHDVCLTIVLVVGLDIGYEICKSLTRKGVFTNYLKKSLEDSVMKQLELMFPIIYKRSKVIDKALKDSNMTCIFALSWPLTWLSHSLQNYEHIILCFDLFLSSHSLMPIYLSSALILSREKEIQECENDMGLLFGILNKIPKNCQIHEIIVDAQNLFQDYPPLNLKKRLMNEYLEDRKTPIPRPKDPIPRNYTYGFWVAAGVVGLAAFYFYIQNSVFNSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7W7</accession>
    <name>A0A0N5C7W7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7W7"/>
    <dbReference type="STRING" id="174720.A0A0N5C7W7"/>
    <dbReference type="WBParaSite" id="SPAL_0001402900.1">
        <property type="protein sequence ID" value="SPAL_0001402900.1"/>
        <property type="gene ID" value="SPAL_0001402900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001402900.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38259" checksum="51471CF01BD3F3FF" modified="2015-12-09" version="1">MALSNNGSLVKSEQSIDVSNSASSSNDFSNDAEGVWSPDIDQAFHEALQIYPPCGRRKIILSDEGMMFGRNELIARYIKIRCGKTRTRKQVSSHIQVLARKKARENQAKIKQEIKLPEAARRAAAEVAATIEAGSISKSASITPPHDYTNTKMLDIPVHIPAPNNPIFFSFNNISIPATGTPQPIGMGRISNSTNYLLDTIHGNEENFCAIPDDALKNKNLHNLKERIVASSKLVLCGFTAYIRENTGEQIDIVKINQVSDEPLESIKFDLIASKFPEEFRVLFDNGPPDSFFLAKCWGNLAFNLPSEERKANVIYAVDSFYDSLTKFDISVSTKAITFAKEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C853</accession>
    <name>A0A0N5C853_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C853"/>
    <dbReference type="WBParaSite" id="SPAL_0001410850.1">
        <property type="protein sequence ID" value="SPAL_0001410850.1"/>
        <property type="gene ID" value="SPAL_0001410850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001410850.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8767" checksum="0C1C82CD1A4A3352" modified="2015-12-09" version="1">MFNVINDRNVNICVIKVITPKPAIIYEECFENIRAIMIRLLGCILQQRESTMISNIPLKCFWYYNAQPTVWMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8W8</accession>
    <name>A0A0N5C8W8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8W8"/>
    <dbReference type="STRING" id="174720.A0A0N5C8W8"/>
    <dbReference type="WBParaSite" id="SPAL_0001435200.1">
        <property type="protein sequence ID" value="SPAL_0001435200.1"/>
        <property type="gene ID" value="SPAL_0001435200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000040">
        <property type="entry name" value="T-cell leukemia homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042247">
        <property type="entry name" value="TLX1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921:SF6">
        <property type="entry name" value="C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921">
        <property type="entry name" value="IP01054P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001435200.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="23115" checksum="50782FBFD567D924" modified="2015-12-09" version="1">MSINTSNYVNKNKSSETNDEKKVKENKKLSFGISAILNIDDEENHNHVDNHLPDDYKPLLDTKHDRINYFVPIKPKLQSFDTKNILLNFIQARNIFRQEKRIGHPYNSRAPPIHKKPRTAFTKEQIMILEDKFNNQKYLASAERIELAKKLDMTESQVKTWFQNRRTKWRRQEAEEKEVEDKNVKKMTITQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9A8</accession>
    <name>A0A0N5C9A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Not3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9A8"/>
    <dbReference type="STRING" id="174720.A0A0N5C9A8"/>
    <dbReference type="WBParaSite" id="SPAL_0001449100.1">
        <property type="protein sequence ID" value="SPAL_0001449100.1"/>
        <property type="gene ID" value="SPAL_0001449100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="555"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="322"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001449100.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="77755" checksum="84AD310FB2BD2838" modified="2015-12-09" version="1">MAEKRKLMQEIERTIKKIDDGMEEFDNIMEKMRDAISDNQREKLQDDLKKEIKKLQRLRDQVKGWVNCSEIKDKDNLLRYRRLVELKMEEFKDIERENKTKPHSKQGLSAEEKVDPREKEKHDVMDWLSTQIRSLQDHIDLTESKIELLANVDNGKRRKGKDDSKKGAKEKQAKVEEHRKHLERLKYHQSNLEVCMRLVNNEELAPNVIKERLQDDIEAYVEALGNDEDMESYDPDGIYDDLDLSAFNAHNIAGVHVATDEDHGKQENGEAKHLVLSNSEQLSPALQSPKQEDREKHANGDRKNSSSPAMVIKFVAPLKMPGSRQISGESSIASPPLPVTPPPPPSVPYNSVAAGKMTASGAKLSSENHVPSTPISSKQDKTSAPTTPSTPGLFSSVAAAGISSTPSVKTNVNINDENSAPTVITNDPTQSLDNLTRRRQIANGNGSINDILVTKGFGASMQSSSGNKETNSVSAQQQISPKDQSTMPVNSVISSDPGSEVIDNDIMEQAIAATQHMKISMNSGYHGPTNPMLSFHKSPPRLEDLQILIDLAFEKMPQQTDSEFARPYLPRVPVNSTIMSYPRTVHPTMETLDYYLRLGVESLFFTFYYMEGTRAQLLAAKALKKQSWRFHTKYNMWFQRQEEPKTITDEFEKGSYLYFDFERWLQKKKDSFLFEFQYLEDVDFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAM5</accession>
    <name>A0A0N5CAM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001494600.1">
        <property type="protein sequence ID" value="SPAL_0001494600.1"/>
        <property type="gene ID" value="SPAL_0001494600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="108"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001494600.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30844" checksum="41B48781ED79229C" modified="2015-12-09" version="1">XDDWKECELVSKIDQSCFKIKDGETYHIRASDAVKLSTVKVSSEFKDQQLWNIHNDEVVKEPQDPLESSDAESTTTAAAPLNDDNDPINYLPDRCVNQSEVDAITKDFVDDWIVASDAAEANINNHTSKGWAIVATNGTQVIIQGKKVHGNTSTQKLELEAAVKGLEFLRANSKKGLILSDSGFVCSSSQCNYDVTAFPDLWSSFKEKKGETRIVHVSAHSKIVLNEMVDLFGKCYAAGIVEKDMEWPCDLNTAVIRSQEFKELLNKLLKDDAADIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC53</accession>
    <name>A0A0N5CC53_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC53"/>
    <dbReference type="WBParaSite" id="SPAL_0001546100.1">
        <property type="protein sequence ID" value="SPAL_0001546100.1"/>
        <property type="gene ID" value="SPAL_0001546100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895669" evidence="2">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001546100.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39859" checksum="6FCCEB5CC25E8619" modified="2015-12-09" version="1">MIYSKSFLLSSLILFVGNISIYSLENFKPNDLVEHYLNYENRALTNTNLDELLRQDCSEGSNVYVPLGGRRKPQRRRKRRDRGRQEVLRKKQRLQRVLRQRKTQQKLRRMRQKKIRQAIQRRKRQQQAKLRMRRRRAQRLMKQRQAERKRKERERLRLSRTTVRPGITAKRVTRARQITTTRRSSRGSTKKFDNLSTRRPGKKSTRRSGRGSTGGSSNKSNRESSSKGSTLSRSRSRQNEPPDDEEDESTTDEQEENKPATEKQEEEEEETTTSEQNEEEFYDDEDEEESGTTLAEDDYEEQEGTDIATEPKKEENEEPTTTHPDDRNIRLPQVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCL1</accession>
    <name>A0A0N5CCL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCL1"/>
    <dbReference type="STRING" id="174720.A0A0N5CCL1"/>
    <dbReference type="WBParaSite" id="SPAL_0001561300.1">
        <property type="protein sequence ID" value="SPAL_0001561300.1"/>
        <property type="gene ID" value="SPAL_0001561300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001561300.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23637" checksum="7B298EA39F99C5F9" modified="2015-12-09" version="1">MSKGEVSTKYHRPWERLNMDIRGPLPITGRKNEYLLVVADDFSKFTIVILLKKMNTENIIYEINNQVFSRYGTPKVIRLDNAQYFVNNLFNEFMKSWNVEIRTSIAYNHYSNGLVERSNRTINEIIACYKAEENWDIVVPTVIGVYNNQVNTSTGQKPFEILHEKNKEQCHRCSIHDQSFKSTRGAYQSRRNHLKSKRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD40</accession>
    <name>A0A0N5CD40_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD40"/>
    <dbReference type="STRING" id="174720.A0A0N5CD40"/>
    <dbReference type="WBParaSite" id="SPAL_0001578600.1">
        <property type="protein sequence ID" value="SPAL_0001578600.1"/>
        <property type="gene ID" value="SPAL_0001578600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000064">
        <property type="entry name" value="Phosphofructokinase, platelet b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="55"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="444"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="15">
        <location>
            <begin position="444"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="571"/>
            <end position="575"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="616"/>
            <end position="618"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="704"/>
            <end position="707"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001578600.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="90818" checksum="9E67CD19D5540B77" modified="2015-12-09" version="1">MDQNSTNNGGEDVVGPLPNFPELERKSIFRKDSIVPVIGKEGHRIERNIYEGSNLAVFTSGGDAPGMNAAVRSVVRMGIYLGCKVYFIYEGYQGMVDGDEYIKEATWNSVSDIIQKGGTIIGSARCKEFRTKEGRLKACYNLIKKNITNLVCIGGDGSLTGANTFRIEWPDLVKELQDSGKITPREAAQNENIQIVGLVGSIDNDFCGTDMTIGTDTALQRIIEATDSVVSTAQSHQRAFVIEVMGRHCGYLALVASLASEADFCFIPEWPPSVNWRDILCKKLAEMRSDGQRLNIIIVAEGAIDLSGEPITVDMIKDVVKEKLKYDIRTTVLGHVQRGGNPSAFDRLLGTRMGAEAVLALMEMTPESHPSVISIDGNQIVRVPLMKCVERTQAVQRAMDEKNFTHAVELRGRSFQRNLETYRLLTKLRTPKMKNGVEELPSFNIAVMNIGAPAGGMNAAVRSCVRMGLYNHCKVFAIHDSFEGLAKGDFKEMKWSDVSGWVMHGGSFLGTQKQLPNENNLSKINEQLGKFNIHSLIIIGGFEAYNSAIILHEARKNYPNLRIPLCVIPCTISNNIPGTNFSLGSDTSINQVCEFIDKIKQSATGTKRRVFIIETMGGYCGYLATLTALASGADNAYIYEEKFDINDIKEDCEVIKHKMESGIQRYLIVRNEKANENYTTEFVMRLFNEEGKGVFSTRVNVLGHAQQGGNSSVFDRNMGTKLAAKAVDYVLSQMKETINVEKGEKNATSEDTCSLLGLRGRKYEFTPVTDLINETDFNVRLPKNQWWLKLRPLLRILAKHNSSYVVEAEEDSDSEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEH7</accession>
    <name>A0A0N5CEH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CD36 family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEH7"/>
    <dbReference type="STRING" id="174720.A0A0N5CEH7"/>
    <dbReference type="WBParaSite" id="SPAL_0001626500.1">
        <property type="protein sequence ID" value="SPAL_0001626500.1"/>
        <property type="gene ID" value="SPAL_0001626500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF103">
        <property type="entry name" value="SCAVENGER RECEPTOR (CD36 FAMILY) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001626500.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60434" checksum="F5109DBBB6672BF1" modified="2015-12-09" version="1">MYTASKSSILSYKNKNKKVYKKVGCSFSAFCGILLLIGGIMVLSLMPYFIEDFIRIEQQLVEQKSLFSKWKYPDYDITLNVWSYSVTNPDNITDGEKPKIVSKGPYVFDEKQYKKVLSRGNGTIKYRNFMNFFFNENKSCSNCDLENDHVWIPNIVYQKFVDAALNPAMQVASTALQLQTPFLDVKTKELFFVGYVDPFLSQICSLPFMSILCESLLNMPERIGLFYERNNTFDGEYIIRDGSQDKSRTLGKIIAWNGDNHLPPTWWSKSQASLINGTDGGLLHPYVSKDEKIYIFSTFICRSIYLVFEKEIDYHGVKGYRFVAPVELFDWSRKENEGFCHTNTKKYFKEQKDNCMPNGIMDLSRCLRGNPDIVSSMPNFFGADEYVQKSVEGMDTPNAETDQIFIDVEPRLGTLLRASRRLQINFAIRSGANISNFYYPKMKSNFVPVMSLRENVEIGKANLQEIKDRLYHIESLVYWVSLGSSIFGVILIIISIILFCSLRKSKKYSTASSIHPSSQTPPVILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CET3</accession>
    <name>A0A0N5CET3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pribosyltran_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CET3"/>
    <dbReference type="STRING" id="174720.A0A0N5CET3"/>
    <dbReference type="WBParaSite" id="SPAL_0001637000.1">
        <property type="protein sequence ID" value="SPAL_0001637000.1"/>
        <property type="gene ID" value="SPAL_0001637000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001637000.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40766" checksum="312E57484CA73083" modified="2015-12-09" version="1">MIADDSTGMVILTGNSHPNLAKRVCEILGNNLGSCVVYNKTNRETSVDIKQSVRGKHVFIIQSANKDVNNNIMELLIMIYACKTSSSKTITVVMPYLPYSQQCRMYRRSAITMKLVADMICKSGASRLVSLDLYKKEIQGFFSIPVDNLRSSPFLLQYIKENIADYKNAVIVAKSPGTMHKATSFADRLRLSIAVIHGEESQPENEEISKEDGRQSPPMRCSSSSASLEDVKKQSTSYELYPAAFAKERPPMNIVGDVGGRIAIIVDDIIDEAQSFVAAANVLKKRGAYKVYVVAVHGILSGDAPTLIEDSCIDQVIVTNTVPHDMQKMRCHKIKTVDVSIMLCEAIRRIYHKESLGFLFRDVTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF19</accession>
    <name>A0A0N5CF19_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SKIP_SNW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF19"/>
    <dbReference type="STRING" id="174720.A0A0N5CF19"/>
    <dbReference type="WBParaSite" id="SPAL_0001645700.1">
        <property type="protein sequence ID" value="SPAL_0001645700.1"/>
        <property type="gene ID" value="SPAL_0001645700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001645700.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24271" checksum="9A82A7E82D9E269E" modified="2015-12-09" version="1">MREMARKAREENSKIKKESADNEESSEDVKQRDEIRKERLEERRRERAIARKNPEKLERLKREQERDISEKIALGLPNTRNNGAGTGEVQFDSRLFGKSSGLDAGGINDETYAVYDKPWRPTENIQQHVYRPSKNVADPYGEDLDKVINTNRFVPSKGFSGTDGSTQRSGPVQFEKEDDIFGISTLFDAVKSSKKRTKDDEKDTTSSKKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFB8</accession>
    <name>A0A0N5CFB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFB8"/>
    <dbReference type="STRING" id="174720.A0A0N5CFB8"/>
    <dbReference type="WBParaSite" id="SPAL_0001655400.1">
        <property type="protein sequence ID" value="SPAL_0001655400.1"/>
        <property type="gene ID" value="SPAL_0001655400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001655400.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34243" checksum="2E0A1F60ACD8C86E" modified="2015-12-09" version="1">MQIVLKEKYSDYSEYSKLEVQPSSVVNNITPFSGVEDSPPNSVASSNGVVKNNNQRSTKISKEMTLEEIKQRRRSINAERQRNKRRDESPNTKERRRALNAQRQRERRANESPETRRKRLDANAAYQRKRRAEESPNTRQRRKSLEQAKRNSRKCRPSVDSTGTNTPIYENSNESSSAPISITSTSPVSIKKEFNEIPENHQTMVTINNNIPRHHPQTIGQIQQIQPQVMVILPSENNNPLISQEVLATTQNTIMPPITDGQTCYIVTSPLPQNSYVHSSMFLQQQSTNQATNLTNMSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFN7</accession>
    <name>A0A0N5CFN7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFN7"/>
    <dbReference type="STRING" id="174720.A0A0N5CFN7"/>
    <dbReference type="WBParaSite" id="SPAL_0001667200.1">
        <property type="protein sequence ID" value="SPAL_0001667200.1"/>
        <property type="gene ID" value="SPAL_0001667200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001667200.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50008" checksum="93CAF001486718F1" modified="2015-12-09" version="1">MNNQSSIETCKELILFLFTCEDLRYCLKSLSCVTKGTKGVLQERLIQQLETKETKKKAVKSILDKGHAMGYYSSSMPKDSLRRDDEVENGGTESDTNIPIKKLYFHKNVKNLSGWKVVSSRDRSGLSLFTFKLPNKVRNSLFCSKDSEPSRKCLMLRCVDISEKSDLPFDDCYPLGMRIFINSQEFTDLLPREIFYSNLDLKHRLNAPTNLNKALLKLSKTSRLEDSLQMKICFDRSLNIGSTFAFAVFSSTIKTVEELLIETTNKDNKRTVEEFKDDLEECLSRKKGIIVESIKVSLNSSITLEKIKIPFWGRNCNHIVPEDLETYIKINETTESWLCKYCKSPCTPDDIVVDEFFIKVLQKHPNINDIELFPGAKYKIVGCKEMLNIDNSKVIKGGRRSYNKIEMLMSDGEEDRSSFLILSSDEGNDGENSEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG39</accession>
    <name>A0A0N5CG39_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FtsH_ext domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG39"/>
    <dbReference type="STRING" id="174720.A0A0N5CG39"/>
    <dbReference type="WBParaSite" id="SPAL_0001681800.1">
        <property type="protein sequence ID" value="SPAL_0001681800.1"/>
        <property type="gene ID" value="SPAL_0001681800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001681800.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30150" checksum="445E67FB68A99C75" modified="2015-12-09" version="1">MVNILKICCQQRILNFNLSYSRKYSTRLLKNASIYCTSTSSEILDKNPSSLTFLRNVRTFSKNKEKKSKYSNDEENKNEENRGEGKENVVDIKFNPPRSFLIGYLVLSSFLFFVVYLYKERTTQYTGEYSLENFLQNYLPTGEVKRVQIFPKLKGMIVTLQDGAIINGKTVKNVNIAFKLDSSNNDPDNIIRRIREKEAIMNISESERIPVITNSDTGLYLASWGFMMALVLLPIVMFFKIRGNILKRMAQKAKAKNDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGM6</accession>
    <name>A0A0N5CGM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGM6"/>
    <dbReference type="STRING" id="174720.A0A0N5CGM6"/>
    <dbReference type="WBParaSite" id="SPAL_0001700200.1">
        <property type="protein sequence ID" value="SPAL_0001700200.1"/>
        <property type="gene ID" value="SPAL_0001700200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="7">
        <location>
            <begin position="308"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="6">
        <location>
            <begin position="451"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001700200.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="69415" checksum="98ED417191711AAB" modified="2015-12-09" version="1">MSSISKKIKKKEYELTRGFFQLLAENNADRLKPVVQIINSRPSNNGSSIGLRLSDGTFSFGAVFLKDNAIKKFELYELEKSQSVIKLIGFCSNIANNEKAKRVYLYIFDFELLEKDSPIIGTPKPHSGISVIFLALKDGKVEQGPLNKLNSQLQAKEVIKVAQSVKSVSSENDASIVPIVSISPNILQWKIIGTVTEKSEIRYFDTPKGRGEVFDFFITDKEGTEIRVSCFGYMAYKYNEFIELYSSYTIKGNNKAITLAKKGYNNTGHEYEIVMRDDVKVTRYKNEITLPPQKIDRVNLSKIKMFLGEYIDVIAVVHNMEEPVNVNGKNGVLNRMRVSLIDESGSLVTLTIWGDSCDEFTEDLLHKPIILKNVAVTEFSGIFNLTFGFRSRIIPSEDVDIVEDISEWYTRERGNIQISNISSSPTTINNNVTIHSVIVSCLNDNNIKEGYFNVIGRVGRVRENLVYKACLQKDCREKVVLQNGKYYCSKCNITLRNFKYVLMVIFKIYDHTGSHWVVMLNDVAERLLKKKASKVGGIIKAHGELEGCNIVVSNLVNTLHDFKVRFKIRSYKGRTVAKWCCVDVKPVSLTKYADCLKEWCKNAEEFCSKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHH0</accession>
    <name>A0A0N5CHH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHH0"/>
    <dbReference type="STRING" id="174720.A0A0N5CHH0"/>
    <dbReference type="WBParaSite" id="SPAL_0001728700.1">
        <property type="protein sequence ID" value="SPAL_0001728700.1"/>
        <property type="gene ID" value="SPAL_0001728700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="316"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="6">
        <location>
            <begin position="543"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001728700.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="68653" checksum="7AFB0CF97FFFEE6E" modified="2015-12-09" version="1">MSKKLQLLRNLMKSGSLTKGKVVNAYLLPRTDPHDSEYISAPYERVKYISGFSGSNAIVLVTNLIALCWTDGRYFDQATQQFEEGWHLMKQGVPESQSTSEWIALNMPKGSVVAFDPLLVSSSTAKELKDKLKGMNIELLPVERNFIDELWKERPEAKATKVRLLGLEYAGESVSTKIGNLRHELKEKKCDSIVLTLLDDVAWLFNIRGADIEYNPVVLSYAFITMDEAYLFIDKKKLPEGYEEHLKGVKVLDYDKVTEIVNEYHSKNKENASHKMWIPSETNYWISSVIAESNAYDANSPVQILKATKNEVELKGMRQAHIRDSAAVIEFLIWLEEELNSGKVLSEKIAMDKLETFRATKDKFVSLSFDTISAVNEHAALPHYKMTENSSLPLKASDVYLVDSGGQYLDGTTDVTRTVVVGDDIKDEFVDLFTQVLIGHIECATAKFPEGILGNRLDSFARHALWDNGYDFGHGTGHSFGSFLNVHEGPGSISIRHNNPDGRLKAGQMMTIEPGYYRTAHWGIRIENCYEIINCNVTSGATNFLTFQPLTLVPIQKKLIKKNMLSAKQVNWLNDYHRVVYDTMSAYFKNHNQEKEMSWLKDACSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2A7</accession>
    <name>A0A0N5B2A7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2A7"/>
    <dbReference type="STRING" id="174720.A0A0N5B2A7"/>
    <dbReference type="WBParaSite" id="SPAL_0000020900.1">
        <property type="protein sequence ID" value="SPAL_0000020900.1"/>
        <property type="gene ID" value="SPAL_0000020900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000020900.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18611" checksum="1226515569AD16ED" modified="2015-12-09" version="1">MPEVKLIVHDDSQVLERSILKGEITVGNQTVVQPYASLLATNGPIIIGEKNIIEEFVTIENLNENGEPLIIGDKNTFEIQSTFRGKSVGNQNLFSVRSTVGKNTIVTDSCCIGIKCTVPEGEVLQPQTVVYGENSARRTVCEKGQNTEDELDFLLKMFPKYHKSLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B339</accession>
    <name>A0A0N5B339_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B339"/>
    <dbReference type="STRING" id="174720.A0A0N5B339"/>
    <dbReference type="WBParaSite" id="SPAL_0000049000.1">
        <property type="protein sequence ID" value="SPAL_0000049000.1"/>
        <property type="gene ID" value="SPAL_0000049000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000049000.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15268" checksum="1645748249D0454C" modified="2015-12-09" version="1">MVRKRTASPASSGPVRRSSPPPTPAAAPAPNYSAPPAPVATPMAAGAAPKQPGLMAQMAATAGGVAIGSSIGHVVGNMISGSGSSNDNVQPSTAPAPVNYQQQQNYQNPCEFEYRQFFECSRNTSDINLCSAYHDLFKECKVRNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3D3</accession>
    <name>A0A0N5B3D3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3D3"/>
    <dbReference type="WBParaSite" id="SPAL_0000058400.1">
        <property type="protein sequence ID" value="SPAL_0000058400.1"/>
        <property type="gene ID" value="SPAL_0000058400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000058400.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31962" checksum="DC2A5979F4EEA2A8" modified="2015-12-09" version="1">MNPMYYDNINKCRVIESLYYPEPKKEVQPNVVIPTVEEVAEEVIEEKPKKVNKNIKKGVKFDEETINQTSTPVFSTYYLDQNLLQPNFFRKKVQSYYHENIPEQEMENIFEEELGTKLSDERKAKLLKDFQKAKEEYEKVLKKMRIAGLDECEQEIIDEGNGNDASMALKHTSKTCDVSAKESTYASMPDIKYCFGQNNVNSGYHYDKPTQVISKEVVPSSCISEDQYVYSDSQISIEESLTNVHQSTEDVFSKNYKMIQSEYHNPGLNNYQGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B467</accession>
    <name>A0A0N5B467_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B467"/>
    <dbReference type="WBParaSite" id="SPAL_0000086900.1">
        <property type="protein sequence ID" value="SPAL_0000086900.1"/>
        <property type="gene ID" value="SPAL_0000086900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000086900.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19215" checksum="CD6B9C4F82D8B8AE" modified="2015-12-09" version="1">MDIRKDDSSINSFPYKILHENGSIEDDGSTTYQYIFNNPLDINSSNNSESLYTDEFIKKDYEIFHDDDNMIQSQLNTNIENFLEKLPNMNPIAKPDTIQLPRKISEVRIRNIEQMALEEPTKINFRQKCLILYRNKTPKDYILISSIVILILGIIVLIFFLIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B591</accession>
    <name>A0A0N5B591_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B591"/>
    <dbReference type="WBParaSite" id="SPAL_0000123700.1">
        <property type="protein sequence ID" value="SPAL_0000123700.1"/>
        <property type="gene ID" value="SPAL_0000123700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893977" evidence="2">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000123700.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21031" checksum="9CD03E32C2BB2F89" modified="2015-12-09" version="1">MNFLKYLIILGLCTIQYSIQGSSSEEDSSSVSGKNDSSEEGSDLLPEVSTDSTNSTMNQENNKTDSERKSGAKKFFSKLGKGAKKVMKSEATKKIGKSIAMGGIKLVQSLMENSNEKKNKKKKEEKNSLLGGLTSLLGKKHKKTKENESEKKKSKDEEEKSGFFGKLKDKITDGAKKGLAKQMSKQMFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5H8</accession>
    <name>A0A0N5B5H8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5H8"/>
    <dbReference type="WBParaSite" id="SPAL_0000132075.1">
        <property type="protein sequence ID" value="SPAL_0000132075.1"/>
        <property type="gene ID" value="SPAL_0000132075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000132075.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8916" checksum="93306E7E614B18CA" modified="2015-12-09" version="1">MECLNAILSNVRTLKKKAGEFSEKTQCVKKYASKCLSISKEIKVLNDKTQQHCANFEPRLKSVRKKLVDVKMKTGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5X2</accession>
    <name>A0A0N5B5X2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5X2"/>
    <dbReference type="STRING" id="174720.A0A0N5B5X2"/>
    <dbReference type="WBParaSite" id="SPAL_0000146400.1">
        <property type="protein sequence ID" value="SPAL_0000146400.1"/>
        <property type="gene ID" value="SPAL_0000146400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000146400.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26252" checksum="A3B3F701C8AD4378" modified="2015-12-09" version="1">MNKINEKSTGVSGEMAIYVKNNINIYKLKIYNNRIAVVQQLNNKVLTTYIGIYAPTDDNNDETKNKFFAEVNEVIELSINEDKKNKDIIVRKPVILGDFNGYIGRNKMKNIHGGYYMCSEVNNNGIRLLELAMKLNISVINTYYKRRNSSRFTWSNTSKTQRSEIDYIVGERKLITNFRILTFSQFFVNSDHRAISCKYQIPKVILRRRKMKLNGTVDIDVANKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B674</accession>
    <name>A0A0N5B674_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YtxH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B674"/>
    <dbReference type="WBParaSite" id="SPAL_0000156300.1">
        <property type="protein sequence ID" value="SPAL_0000156300.1"/>
        <property type="gene ID" value="SPAL_0000156300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000156300.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8526" checksum="7CD21094A2BCAFB9" modified="2015-12-09" version="1">MDQLRKVTDECKNSVNSAADKTCNAVKNVSSDVCDKGSQVIENAKKTASEMVDSTKESLENTKKTISDKISPEKDGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6F2</accession>
    <name>A0A0N5B6F2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6F2"/>
    <dbReference type="STRING" id="174720.A0A0N5B6F2"/>
    <dbReference type="WBParaSite" id="SPAL_0000164200.1">
        <property type="protein sequence ID" value="SPAL_0000164200.1"/>
        <property type="gene ID" value="SPAL_0000164200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF33">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000164200.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22719" checksum="46315724F069DBA9" modified="2015-12-09" version="1">MEIVRTKLLEALLERNVVKFGEYYLKSGQKSPIYIDLRGLISSPKILSLAAESLCSQIKESNIQFDYVVGVPYAALPLATLVCDRLEKPMLMRRKQAKSYGTKKLIEGEYKSGGKCLIVEDVVVAGESIAETVEVLKNEGLECVDAIAVLDRMQGGTENLEKINVHLTPVLTLEYLLDYMISKNLIDQGKKQYIFDELAKPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6J7</accession>
    <name>A0A0N5B6J7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6J7"/>
    <dbReference type="WBParaSite" id="SPAL_0000168500.2">
        <property type="protein sequence ID" value="SPAL_0000168500.2"/>
        <property type="gene ID" value="SPAL_0000168500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000168500.2"/>
        </source>
    </evidence>
    <sequence length="1170" mass="135943" checksum="957AC98825449425" modified="2015-12-09" version="1">MSLMNEMIDNVKQLVKDKQFKDAIIQAENLFGYQVDDYNLFMFTANAYLQTENYEKCYEMLKKGIRMKPENKTGYAGILKLYLDKRIPGNNDIKKYIETLIKLDSKNTTKMDDIQKALKNLYIELKDFEALGKIIENDSTLVKELLEGDFLNQMSEDFFLICVRKIFISDEIDLRIENLIKIKEKILEFNIELDKKDYDKLMSKILDQEVKDKFQISLALALDLISFIMNEWYEVETISAKYLANLNRFYIMSSTDDCNTFISYQSTLELLKEFVNDDYSANSQLASKYLTVAKSPKATVFPLSAALLSLFCLTHNHLAADELIRKIFHTQGGREQLFDRTLYLYYGAYLECHWFLDSEDKVLLLDDSSLSNKAIFFSRLFQIECSAKENVDDIIDKSVKSFSNNQSEIRCIFEYLGRKKESKDVLKVQSKNIISALIPILCKRGFDVPISELNDIIASLKNLLNSYPNQSYLLFCIGMIIRNKYPREAWACFSSIFPKLYFNHTLTKAMIEMSEILVIPKSQIVNVMDSYYKYGPTDHTFIVKYCKILVHMKNFDELKNCLSIYFQKYANYNDTKDIISLNEYQQLKMMWAISFKELGLYRKALTIIDHVYKDDVNHLEEWVVIKLTCYVEDKKLLDAIKFYEDEAFLFISSNKIHGLALYSYLQLLTITPPFSKQKILCLKGIYGILYNPSISFEKSYQLLVSSARHYLFLELAFMNNTVIKEISLPLISDSNENLKSLCIDLAFNETLSILETCFDNDITISIEHLREIVRCLIIKYNQEKNAQYLEIALECLTSMEGKADDSMLFEVLLTKSIVLLFVKRFDESKKILRRLTEMNVKALKPWLLLFVIEVLSEKINNENVVKLVETCVTMNNDDPMVPIMVVIAALNNSHSGHDFECEAWECLFRQIVQSSIRGQTLTVVELFSFFRLMKPNQFDNNYCDSEMQDFWYAFKSHMVKKYINYGNEEDEFTGKFLRAFAALELNDINYAEEIFSEMSESDNELIKTVKALTLAINKLQHGGTKTDALDELKKAPLLKNVEKTLDNLNVSNDNLPTNIITLLKSVEENDTEMFKCVFTPKYASLILCYIYSKKLNVSNEIFEAMEKYPANILVQCNPYDNLDVKKMIEIEGGYSEKGAELVTESEGDKILLEKTLYLKLMYLKEQYETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6R2</accession>
    <name>A0A0N5B6R2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6R2"/>
    <dbReference type="WBParaSite" id="SPAL_0000174850.1">
        <property type="protein sequence ID" value="SPAL_0000174850.1"/>
        <property type="gene ID" value="SPAL_0000174850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000174850.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="49107" checksum="107F5AC1971A4D99" modified="2015-12-09" version="1">MPTRKRQFYARCNLLYIPYYCILMGSKTIFMNIPIYNNFHESYGHLIYIFAYIGEAIGTIFGSTLHFLFGYKLTFCYCSFVIATFYFVTLTSKPVLLLLSSFILGFFFGTLWLTTFRLLSFSASHPDATRFSVFFQLSNFLHVNILPLLFSHSLGPNNITDRLLGNDGNFTKFYQLILAKESYEILLICLIITLLGSTLIVFQPKLWKIVGIKVQILSNIYRLTLVDYIENRKELQKVVKVLYQQNRRNHLKRWLKDIIKSSLTKSHRYKFIYSSIGIILLTFYVIYVEWKSPRIDNPRYYLSKSLNTFGRAEETAENVARIIVIIFLSFLYGTLEYHIYCYYQLIAREFGLKAMLIPRITQFLFNAIAMVLFLEIPIILWLLITMFLTFISAVIFFHAEKYTIRGVCITKGINPASTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B789</accession>
    <name>A0A0N5B789_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B789"/>
    <dbReference type="STRING" id="174720.A0A0N5B789"/>
    <dbReference type="WBParaSite" id="SPAL_0000191700.1">
        <property type="protein sequence ID" value="SPAL_0000191700.1"/>
        <property type="gene ID" value="SPAL_0000191700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000191700.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38797" checksum="D254FD3704E0A99B" modified="2015-12-09" version="1">MVLFLPTKNTYDSYYRCDFFPLEHWQLEKKPSLGIGLLYIIPGSIFIILYIPILFVMMNKEFMKLSCYKIMIYLVCVDLMTLLHNSLLTGTFSILGSLFCEHRLLMFITGQTALFGWFAGCITVVVLALNRCLDVMMPTVAEKLFGGRRVYFWLVATTTYAACCSLLTPKASFTSKLYAWFFDPYFGIDVKNKIEKVDYSNWVHSINNISEMVCLGVLYTTLCLVMSVKYNLTKKVKISILQKNLFVQAGLICLANFIASTIYVYMQFYVVGVEIVILGQVMWIFSHGSGSVIYLIFNRNIRERLLEKYFFPFFKKSTNRRVVTISIMNKCTVMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7E3</accession>
    <name>A0A0N5B7E3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7E3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7E3"/>
    <dbReference type="WBParaSite" id="SPAL_0000196900.1">
        <property type="protein sequence ID" value="SPAL_0000196900.1"/>
        <property type="gene ID" value="SPAL_0000196900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000196900.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25123" checksum="428C9597C1DCA463" modified="2015-12-09" version="1">MAHTNTVATSGSGAPAAGGQGDNSFDYMFKLLIIGNSSVGKTSFLFRYCDDSFTSAFVSTVGIDFKVKQVVKGDKKVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWCTQIKTYSWENAQVVLVGNKCDMEMERVVSTERGRQLADQLGLEFFETSAKTSQNVKNVFDKLVEIICNKMAESLDKNPNQNPEKGIKVDQPASQKASGQQCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7G1</accession>
    <name>A0A0N5B7G1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7G1"/>
    <dbReference type="STRING" id="174720.A0A0N5B7G1"/>
    <dbReference type="WBParaSite" id="SPAL_0000198700.1">
        <property type="protein sequence ID" value="SPAL_0000198700.1"/>
        <property type="gene ID" value="SPAL_0000198700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000198700.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29537" checksum="C220FB0021C9DF09" modified="2015-12-09" version="1">MGSFGLRSAYGSFGRSTRMIFFTTNLLSIIFLIITLTFGIWMVITYSAYSELLAPSLYVDVAWIMIIVSLLGLGNSFFGYWCIIKEVRCFSYTYCVASIVISTMLFIGGMMGHVFVYKLYNQVPLSLKMLTSLRELYGMPGEEGITNSWDELQKNFECCGVDEKDNWRVWKTSKWHMHYKTNTEKPRIPDSCCKPGMLQHCRGQFLTQEHLYEQTCHSLLNNSLGEVTRVAGYISIGASIVILVPVIFAFLYTRLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B859</accession>
    <name>A0A0N5B859_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B859"/>
    <dbReference type="STRING" id="174720.A0A0N5B859"/>
    <dbReference type="WBParaSite" id="SPAL_0000223200.1">
        <property type="protein sequence ID" value="SPAL_0000223200.1"/>
        <property type="gene ID" value="SPAL_0000223200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581">
        <property type="entry name" value="PROTEIN CBG10435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000223200.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41137" checksum="D84F44AC8967F509" modified="2015-12-09" version="1">MSTNSEKIKKDFNDNLSIMGSMSMVSMTIALASELKVFNALAAVSSKDHPATAEEVALKGNYKPRYIQELLSTLACGDIIEVTDCGKKFWMIDEKKDILTNPTANPAMTIFPEIPVFGKIYNDIKEVCKKDGPLGMQYSAYENFYANMAAFSESLHKKYLESKIVPLSGMKEKLESNQKTECLDVGCGDGYHIVELAHHYPNAKFTGVDITKHAIELAEERLAKEDNKSLKNVEFINMDAAHLREDWSNKFDWITIFDACHDQCRPDLTLKEIQRCLKPDGIFTMIEIKGSSNCSTDKKTNPVGSALLYGISLFHCLPVGNSTEDALGLGTMWGEVKAVQMLKESGFSTVEIVPTPFFPMNIMYKCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B876</accession>
    <name>A0A0N5B876_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B876"/>
    <dbReference type="STRING" id="174720.A0A0N5B876"/>
    <dbReference type="WBParaSite" id="SPAL_0000224900.1">
        <property type="protein sequence ID" value="SPAL_0000224900.1"/>
        <property type="gene ID" value="SPAL_0000224900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000224900.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13186" checksum="48AA033227057D60" modified="2015-12-09" version="1">MASKYSLRLGNAFSVVYVTVPKMENAKTIARSVVEGKLAACVNIIPKVTSIYSWKGNIEEDEEYLLIIKTKKNLLNELKSQVIKDHPYEVPEFIALPIEEGSDPYLQWIDNQTKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8L5</accession>
    <name>A0A0N5B8L5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8L5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8L5"/>
    <dbReference type="WBParaSite" id="SPAL_0000238800.1">
        <property type="protein sequence ID" value="SPAL_0000238800.1"/>
        <property type="gene ID" value="SPAL_0000238800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000238800.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38358" checksum="EC7595D761376E6A" modified="2015-12-09" version="1">MKILVTGAAGFIASHTVLELLEANYEVLCIDNFSNSIEDENGEAISLKRVSQLTGKKIDFIKCDCTNIESLEKVFKENKFDGVVHLAALKAVTESVQFPLMYYQNNLTSSLNLLSLCSKYNIKNFVFSSSATVYGPPEHLPLTEDSRIGCGLTNPYGQTKYMIEQVLRDIAISDKEWNIVLLRYFNPVGAHQSGLIGEDPKGIPNNLMPYIAQVAVGKLPYLNVYGTDFDTIDGTGVRDYIHIVDLAKGHVAAFDRIKKMKKIGLETYNLGTGTGYSVLQMVAGMEKACGHKIEIKKSVPRPGDVAAVYCDPSLAGEKLGWKAAFGIDEMCRDMWNWQSKNPNGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8P8</accession>
    <name>A0A0N5B8P8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8P8"/>
    <dbReference type="STRING" id="174720.A0A0N5B8P8"/>
    <dbReference type="WBParaSite" id="SPAL_0000242100.1">
        <property type="protein sequence ID" value="SPAL_0000242100.1"/>
        <property type="gene ID" value="SPAL_0000242100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="62"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000242100.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36874" checksum="CB783FE05140DD55" modified="2015-12-09" version="1">MISKKTFIYKLICFLLLLLYFPHFYSVKSLKEPFIESRNVKITKYPKILCVILSHPTKETSTLNHIIRTWLAHCDKSLFITTTREKLHNRGGKMNIEVVKIISEGKKMDIWKKTIESLKIVYNMFFRNNKNQFDWLLKVNDNSFVVIENLKRFLINKDENRSIYYGFNSSSNDISNEIKYNEEYISGGSGYVISRGGIKKLVGKNFAFVDNCNEKEINGFEDIIIGRCFRKFGIEGGDSKDESGFETFLPPVLKKNYILKLSKSGEMYSIFPGDKYACEKLSQYPISFHNIVPENLYILYFIFYKSKVYDGQYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9A9</accession>
    <name>A0A0N5B9A9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Post-GPI attachment to proteins factor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9A9"/>
    <dbReference type="STRING" id="174720.A0A0N5B9A9"/>
    <dbReference type="WBParaSite" id="SPAL_0000262500.1">
        <property type="protein sequence ID" value="SPAL_0000262500.1"/>
        <property type="gene ID" value="SPAL_0000262500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000262500.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30379" checksum="41F4114F24FEA5B2" modified="2015-12-09" version="1">MALGDESLVTVRFSTLAKVVAFCPALALILCIITSMILHWDLVTSTHCGVYNFFPSVSAAIATYNPEKYIWRFLIAIHITPRYVFAFANRNLLIKCPLRPSSSISFFSALCNFSCALNVLEINFLLLLTTISSTDDHFLHKCSFIGFVTTAMIHMYLSTWLYNHSNRRRVTNFGEKIYQKKVLSVISCTLSLSFAMYFYWRHNTYCEPGIYTLFALSEYAYIASNIAFHFTTYYDFLDKRFTLSSSPSSFGKYETLLPTVVYKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9K3</accession>
    <name>A0A0N5B9K3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Survival of motor neuron-related-splicing factor 30</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9K3"/>
    <dbReference type="STRING" id="174720.A0A0N5B9K3"/>
    <dbReference type="WBParaSite" id="SPAL_0000271900.1">
        <property type="protein sequence ID" value="SPAL_0000271900.1"/>
        <property type="gene ID" value="SPAL_0000271900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000271900.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23104" checksum="BB65E059DB1CA23D" modified="2015-12-09" version="1">MSAENIEDLKNNMHQLDQIEIALSTEPDNADLLRLRSDLLEVITLLKDIIEEEGGNIDEILSTTSNSKSEQKKSSNEKPQKTEIEGEKEVHKKKKKFTNEGLSHRERNKMEWAKRMQKQVKREEKQKELEQIKEKEKSSWQNFNSKANVKGLKGIKRVGSIVSSGEGLRSSKAPKTSSITSTRLIYANNTFGNVARGNMDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9P1</accession>
    <name>A0A0N5B9P1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9P1"/>
    <dbReference type="STRING" id="174720.A0A0N5B9P1"/>
    <dbReference type="WBParaSite" id="SPAL_0000275700.1">
        <property type="protein sequence ID" value="SPAL_0000275700.1"/>
        <property type="gene ID" value="SPAL_0000275700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097475">
        <property type="term" value="P:motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097402">
        <property type="term" value="P:neuroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905485">
        <property type="term" value="P:positive regulation of motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904937">
        <property type="term" value="P:sensory neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000016">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF47">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="15">
        <location>
            <begin position="38"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="16">
        <location>
            <begin position="231"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000275700.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63631" checksum="307DC42299D9A07D" modified="2015-12-09" version="1">MFFLKKNLGIGIYFLILFTTSLCIVTVFTVPFNDDYSSNTNKCVPIRIKMCSDIAYNMTMFPNLLQHQKQEEAEIEINNFLPLVQVKCSEDLKFFLCTVYAPFCNVLPKPLPPCRHLCMSARNGCENLMNKFGFNWPTPLDCNNFPVDGLCVGENRTSSSNPSVSKYGHDKKTETNLIDFIDLECPKAMKSRSMNTYQLYISNRTLDQCSVPCKADKIFPMFFDENIRGFIRLWTSTWATISLCASAFTTLTFLIDLRRFRYPIRPILYISICFVGISSIYIIGMTSEGTYACSSISAKGTPLTTQGLDNLWCSVMAVVYYYCQIAGGFWWLILCYVWYLTSNLQWGTEAIEAISSYFHLIAWGVPFLLTVLLLIFPSVDGDMFTGICSMGNLNTNVLFYFVFIPLLVTLVIGLMYLILGIISLLRIRRYLKCKQSDIDTTSSKVQLLMIRISTFATLYTIPTIIFLASIFYQSKYFDRWLTEWYSLRCNHGDRHIFGFSTSRHNCPSDLFVSAPDPLLFYAKYSSQLLIGVICAIWVSSAKTIKSYTNAYSRLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAE5</accession>
    <name>A0A0N5BAE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000301500.1">
        <property type="protein sequence ID" value="SPAL_0000301500.1"/>
        <property type="gene ID" value="SPAL_0000301500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000301500.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59083" checksum="315583C9CFB1D2DD" modified="2015-12-09" version="1">MESGIIVPSVGIEDEGTFSSSFHSIEKEIIINKDAMKTNAKVSENPIQDDKEIIHKDTPLKNRELLIKGRRKRGKLRELINSSKKMYHQENQQLRNFNEDATSISEEKVSISNLIDKRSDKSIIFNSTNDTLNSSVNISDRNMEEMVEETNFNKISSDNINKPKLVNIFEDEQVKKEERIEKEIARKHTDVIFSNINNPKSPKHLDILRTMKNNSTVSTTPKSNVTPTSTTVRSPTDFISGIGNLFSAFGKGIGKFIGFEKDCKNKGYKDGTGRCVCPPFHFGSYCEQVNCANGGKLFPPSKSNPRKLQCICPNPEFINGEFCQYIKCLNGGTPVDGEGRCSCNNNWYSGNFCENYSASWTIVFVIPIIILIIVTFLCAICRLDLCPKRNAYIHESSAINSGRRRRRRRDNLNENYSNNLVSRLPPLDGEERERMVTEHFLNQCRMQRYISTATNTGGNNLSNQNSLTNFLSTDDSVKMLEPPPSYQEALSASPAPPLPVDITTAPRPPAYQTIDPNRRRPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAP1</accession>
    <name>A0A0N5BAP1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAP1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAP1"/>
    <dbReference type="WBParaSite" id="SPAL_0000310800.1">
        <property type="protein sequence ID" value="SPAL_0000310800.1"/>
        <property type="gene ID" value="SPAL_0000310800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000016">
        <property type="entry name" value="26S proteasome regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="210"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000310800.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46367" checksum="6CF0E71878596D20" modified="2015-12-09" version="1">MLLTENILEHIGDGSREDILKSKEEFKREEEEILIEVANELADKGRTDDLRLMIKKVRPFLVSLGKAKAAMIVRKLVDMCLTIEGQNGEIKIELCKECTQWADEQNRTFLRQSLQARLVKLYNDLGKYDEALKLSNTLVKELKKMDDKDLIVEVQLEEAKACYSLSNFAKSRAALTSARTTANAIYIVPKMQASLDMMSGILHAADEKDFKTGFSYFYEAFEGFDSIDDKAEALKALKYMLLCKVMLDSPDDVKSLLSQKLALKYSGRDLDAMRAVANAAKKRSLRDFNDAFMNYKNELQTDLVVRKHFNVLSDAMLEKDLCRIIEPYDRLEIGYIAKKINLPIDMVEKKLAQMILDNKINGSLNQACGILTIHGEEKVNSSYQTAIETINALGEVVDVLYERAKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAZ8</accession>
    <name>A0A0N5BAZ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAZ8"/>
    <dbReference type="WBParaSite" id="SPAL_0000321200.1">
        <property type="protein sequence ID" value="SPAL_0000321200.1"/>
        <property type="gene ID" value="SPAL_0000321200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000321200.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="24130" checksum="3CE709E8D80B96C5" modified="2015-12-09" version="1">MEKLDEENCGPNGTKPLSFFRTNIKVIKSVYLDVEEREAIREELKNHFDTLLYHPVGNNLYCCFIKWRAVISKCRFTFLIRIVKDAYELRLRNNFDLHCMDDWKQKDDEPVRGYNRRYRQRLIELYPDFMNKLYRMTNNRSDEANFLRTEIVGNYIASLKNELVDIMPIFKRNEKSLEIVMETAEYYEKEWAERKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB89</accession>
    <name>A0A0N5BB89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB89"/>
    <dbReference type="WBParaSite" id="SPAL_0000329900.1">
        <property type="protein sequence ID" value="SPAL_0000329900.1"/>
        <property type="gene ID" value="SPAL_0000329900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000329900.1"/>
        </source>
    </evidence>
    <sequence length="848" mass="98389" checksum="CCC7F70A3B0CE6C8" modified="2015-12-09" version="1">MTDQAIPFTFQQGEENVEIFLGAYEAAKKRWADQQKALVRGPNVTEASKTALVKKQTEELQRMLNFYNISERTTYDVPYEWENTTVHPRLEGITKLVLKYLLESKSYKPFLKGSDVDFYNWMTDVMDTIRITVVDEEGFKLANELCMSMTNKFIPRDSEIHLYLQKALRSRVDANGELRNGLMITDLFDEIWQELRNSQVSKKVQVLAKPPTWKYGIDTLGKFNIRYFGYLRQRLGVQNVGAHLDQNLALRKEYYLNYQELIPMAIRKEVRYDVTADTAWDDFITLHLNAESTLKILEDQEKKQKKASEKVKPKSKGNNNFIKNNNFKKFKKRFNNNRKVVNQGNQIGNNNNNSGNYNNNNLRKEIPIKNIIIIIIIKENQVQDMLTAVKLSGVIITCLLIMMMIPSVDARLLPGYKWESCGAPRIPNFYRLTDEYLATVPIRNTTLIAINEDCTPNGEQFPLVGIEVGDLFLQILISAPYRPKEFKYALKPKSYCGLPNAVFLLDSTPHAYIYKDDEVSKAEARETFDTLLKIRLAFLSRCPNWDVESSYETRKTPVVTVSPREEELMLAAIRKADQFQVTQKEGNRVSDNTRSKAIKRTEELLKEYDQLKEYTLTLETQVASLNVDKAHLMQQVRGKASELETSEINRIALSKNADEAKSLSKELEKTRREMLQLFTKEQYANAIETLKKRHTEDIAKMKAQYDNAIREIQTQLDKKESDFKIIGQTRDNLHLELKDINKQAIQFQGDLKQCQIDLQSHIEQLDRSKETLRLREIEIVEKDNKIKEFKKGGEVLGQKLRDQNNKFALAETEYHKMLNKVTSLEEALRNKDIEIANLDEQWKKTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBG4</accession>
    <name>A0A0N5BBG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBG4"/>
    <dbReference type="WBParaSite" id="SPAL_0000337300.1">
        <property type="protein sequence ID" value="SPAL_0000337300.1"/>
        <property type="gene ID" value="SPAL_0000337300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000337300.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19236" checksum="74C39AD014F74589" modified="2015-12-09" version="1">MVLFSYNTLSYGFLIIGIIINLFNKVASLECIQCDRVNNYLSPEELEIYQRQCQEGTLPKTPCLNDTHTHCIYSYFRQGDGTDKVYTERKCGTVNDIFGCTIYKSHRRLKKHLFGATGSLTNQRRRETNMFVEVCTLGCVGDDCLNSSSKINIVIPIIFVSTITLLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC39</accession>
    <name>A0A0N5BC39_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC39"/>
    <dbReference type="STRING" id="174720.A0A0N5BC39"/>
    <dbReference type="WBParaSite" id="SPAL_0000358800.1">
        <property type="protein sequence ID" value="SPAL_0000358800.1"/>
        <property type="gene ID" value="SPAL_0000358800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000358800.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30938" checksum="8655F91602846127" modified="2015-12-09" version="1">MLGPTILQKLQPMNKFYIHTGNLNQLGDLKFKRFKNSAEEFKACLEYLQLPENAGVDEHGVLLLNSKRLSEEPFERDDLKITLKVFLNDFDFSQIEKAVDGTLIELKTDNIEQLIVSFPPFTTEEDISEEEEDNLFLEKVIKIWRDLEEFVGTSKVTNLGVADFNVNQLKKLFDAATIKPCVNHFNIDSCCVVPPELHKYAGDNYIQLLTHNDPSPFPVAEAFKQICELKCTSPECCNTFKPTWAARYTTWVRRRSLMAAKGYIVEFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC87</accession>
    <name>A0A0N5BC87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC87"/>
    <dbReference type="WBParaSite" id="SPAL_0000363400.1">
        <property type="protein sequence ID" value="SPAL_0000363400.1"/>
        <property type="gene ID" value="SPAL_0000363400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894144" evidence="1">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="2">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000363400.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32298" checksum="8B096079B0537954" modified="2015-12-09" version="1">MRCINILSKLLVVLCFYILFHAYVHGYQFNVNYCIDKVEGDKEIDESNIKTGLEMISMRSCINFLYNGTCYMKKTNCGTECTAGCGKWKYANDKKCKACFDPYKKCNENCNKCTHRCEEWKKGNVKECKKSNSKSKECKVKYEECKKIKYKSKECREKYEECKKCKITCEECEKKYEKCKGDCENKCLKSELKCVRECKEVTLPFIRFFYNKGKENSDFNFNGSISLNKEEVYNMEIDMNCNKKPGCIAKKVLMYLGLIPTVRRRDRDYFIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCM8</accession>
    <name>A0A0N5BCM8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCM8"/>
    <dbReference type="STRING" id="174720.A0A0N5BCM8"/>
    <dbReference type="WBParaSite" id="SPAL_0000377300.2">
        <property type="protein sequence ID" value="SPAL_0000377300.2"/>
        <property type="gene ID" value="SPAL_0000377300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894082" evidence="2">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000377300.2"/>
        </source>
    </evidence>
    <sequence length="216" mass="22826" checksum="B6F421713091C5D5" modified="2015-12-09" version="1">MNKLVCLVLTVLLGLSMAEDVKKDAASNYGGAPPAFAPPPFGPPPPFGPPPFGPPMFPPFPFFPKPFFDSYYCSVQATFPLAVEKHNNPGDDVPSGGYGGPGPQGYGASQPQGYGSAPPQGYNAPFPRKHRHLSIMRQACRYSAATSWRSCNQCCQIASHGLTTSSDRIVGALFYFDPVAKNNQGHSPAGGSYGAAAPPEEGSKFVQCVCCAPRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCZ3</accession>
    <name>A0A0N5BCZ3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCZ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000388600.1">
        <property type="protein sequence ID" value="SPAL_0000388600.1"/>
        <property type="gene ID" value="SPAL_0000388600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="219"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000388600.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49502" checksum="FA0CC7AE2ED2003B" modified="2015-12-09" version="1">MKVVDCVGCKRSMSRNLETLQVDVVESIINPMREEKKLFISCFLSDGDVSKLLEEFKSAKNQKIESVESSLNKPTIGHVYVYRTDDEVTGVDRTITPVDSSTQTTKSAEYDNSVLSNIIRNGPRPYEYKYDELAGILTKAKDIISKEPVLIECPIPCAVYGDIHGQYSDLFRWFQINGWPSKTKSVFLGDYVDYGIYGIEVIGLLCALKIEFPNNIYLIRGNHEEEQLNRSYQFYHEVLLKFGKKKGEQMFGIFGELFSYLPLSCLIGKKVLCMHGGLSPKLKSLDSLREIRRPIKIFMRNTLACDLVWSDPIANRRDPAYIPNCRRSPGSSIGQLFSIKAIEDTLKTLKIDLIVRGHQVPLKGINSYADGKCLTLFSAPGYQGDNAFNINWGASLNIDKDFHITINKLRVTRKCRMNRIKVVSARNKFVKNVFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE48</accession>
    <name>A0A0N5BE48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE48"/>
    <dbReference type="WBParaSite" id="SPAL_0000427500.1">
        <property type="protein sequence ID" value="SPAL_0000427500.1"/>
        <property type="gene ID" value="SPAL_0000427500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000427500.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18801" checksum="A6F3750F85525481" modified="2015-12-09" version="1">MPHTGFEPVSSMCYAAQSWTTTQAERNNLLSVEHSIIRRLKLIPEDKWLIKEEDNTFKKLSNEDMYKEIGICNLNRHLAKLKIKFIYKKIDKNSIVQKCLCWYPHGTKKRISRPRDSYFDCFKRSRCVGKNSNNLTLTHLTRHKYNFILNNIVPYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEL4</accession>
    <name>A0A0N5BEL4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEL4"/>
    <dbReference type="WBParaSite" id="SPAL_0000443900.1">
        <property type="protein sequence ID" value="SPAL_0000443900.1"/>
        <property type="gene ID" value="SPAL_0000443900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000443900.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="62915" checksum="D34765331E6A7097" modified="2015-12-09" version="1">MEERNLFLSIINQNHILKTILDYLPIKDSCNLSLTCKNCLEMTRNIKKDGLTYYWNGHALFCTVDSETEIETSEIYPSDDFYIDYPFDLREMRKLKIIIFLRKALVSQEVMKSIGQKLNEILKINFNIQQLSFHFTNSSDAFFAQYLVKEIKNNNIKELEIYILYNFWTITTDDNIFENMVNLKKVRISLQNSFITGIDRRLIDAISLIKDVTLEVYFNNININFDITDISLQNMDNILPYVLSKNINLSITGSYYKLLNLNIFLRDFTFHNFNSLHGLRFDVTSIETLHEFGNYLPFMVNLKWLGIYFDIDNFDPNVNKNNTVYYYKSFKHLNGLKVIKIIFECKKKYNEEDNDIITLEEVEKNEKYKKCCQGELFCLLQNAPETVENLYISEMSELTSKMTCLLSDYFPKLNLLFLKKVPKCEDECLSNFKNLKIYVCHVMNEIKLPKSIKICMICTNYDLPYGDIQRTFIKNVKSINDDNKVFGYYRSLNQFKKEYTLNGILKAKIFLNYFHDYYTIMSYFDDILDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFH9</accession>
    <name>A0A0N5BFH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFH9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000474500.1">
        <property type="protein sequence ID" value="SPAL_0000474500.1"/>
        <property type="gene ID" value="SPAL_0000474500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000474500.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52214" checksum="369D57E5809105A7" modified="2015-12-09" version="1">MGNNNSSKFQRLSKRCLPSSTMSSSVIVSNSEKRCTDQCLKNKTKSMYELSTTANEAKNVRESKENSNHSLLVENKKNELVQNNTNETIKYSSDNEKKKNKLNKRQVCRSQTVKIQLDENVLDIDKKNNGVRPIIKSSSKTMPMIHSSSALNFFSSIRSDNSSITTNNTDTQLSKKSSLRRKSSSKSKDKIDSSLSLIKKGLKKDAHPVSNLGREIIISCFENPHADLGQRVIGRLYEKRIDYQKFIISFGKQNMRVLADQLKLLMENVVANLDNISTIENLSKTYGEAHVDLKVFGFKPDFWVGLADSLTVECVILDQATHSPTDVVAAWSQLIATIFSNIRDGYYGALRLHRIASRKNMLAKQTLSNDISTSNLQKTNMEPTSSIISEPYNNEKDSNLSDLPKTLDNNNDLSCNFIDFSHKKVIELTKNENQSTDHLLEEPNHVDITSPKPTLTRWKAIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH02</accession>
    <name>A0A0N5BH02_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH02"/>
    <dbReference type="WBParaSite" id="SPAL_0000525025.1">
        <property type="protein sequence ID" value="SPAL_0000525025.1"/>
        <property type="gene ID" value="SPAL_0000525025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000525025.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10690" checksum="6C3C137280DA73B0" modified="2015-12-09" version="1">MEQVSYFSKMVSTSLQCCDKVPLKNTPKVVEPLKLVEESVLISHKVDDNCKYSISSPNMGSQAPPNSPNVPIYLGIISKDEALEKAGDGHFYLYHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHC7</accession>
    <name>A0A0N5BHC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000537000.1">
        <property type="protein sequence ID" value="SPAL_0000537000.1"/>
        <property type="gene ID" value="SPAL_0000537000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7381" evidence="1">
        <location>
            <begin position="108"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000537000.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44647" checksum="8834E3B0523D5BA6" modified="2015-12-09" version="1">RNGEFIKTEVKIAENVLPFLDSKYQSSSFDLSKYESKSDSMYRCGTTINKKLEVVIKFAKVSKCHIKINAPNVAPVQKPCKVKPMVPLKHFCYLTEMNRYRRFCGKSNLIIVPYTIKTDGRKSLFKYNGKYYESMKQMSQVIIKHREIKNIGEVYVCNLGFKRNGEFIKTEVKIAENVLPFLDSKYQSSSFDLSKYESKSDSMYRCGTTINKKLEVVIKFAKVSKCHIKINAPNVAPVQKPCKVKPMVPLKHFCYLTEMNRYRRFCGKSNLIIHPILSDIAQRRADSVANYQRLRTDLSRISSNNPYNQYNELIASTSRGSSMLLMYILFHDAWTHNSNFDRPSERKWEMAKLMSSQTRYVGIGISSSQNTVYVCVKFTSDSIYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHL5</accession>
    <name>A0A0N5BHL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NOSIC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHL5"/>
    <dbReference type="WBParaSite" id="SPAL_0000545300.1">
        <property type="protein sequence ID" value="SPAL_0000545300.1"/>
        <property type="gene ID" value="SPAL_0000545300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000545300.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35392" checksum="4DBCA93222C653E2" modified="2015-12-09" version="1">MSVSDDNVSILEYDPATEGSGSTGTNRITKRKRKPKNNVDVVSVPPGEDAVALHIKLLKERENTMEGILGLLELGERVETLLKRTLWAAEADISILEMFSKMHDIHAVRQLYSEKHAAATREAVEEYGIQITPQIRDDLTKQVKASLPKSLDYGVLRTTDEVKTMLQSILNVGAISAQCCISGAGLIIFPAGVAVPNLRQLKIEHLSGAMSGRLPEHLRVANTLKHLRRAVTWSVLLHSAKLRIVIIVQDNRYDEKALIHTESFRKAMFQKRRGIVFHKGPATFKKFAVCRLPSQVRDDHIERKKSRIAIADHLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI29</accession>
    <name>A0A0N5BI29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BI29"/>
    <dbReference type="WBParaSite" id="SPAL_0000561300.1">
        <property type="protein sequence ID" value="SPAL_0000561300.1"/>
        <property type="gene ID" value="SPAL_0000561300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000561300.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28196" checksum="8056EAF282E4E27F" modified="2015-12-09" version="1">MSSNVPVVNNNSMPTSLFGGTSNGNDIIQNFGVXVYPPQLRITETNIGPILVAACKMESPGLLKKCAQLLLSPSTKLSVFVRLSLLDRCYLHEMLSTCLKMITRAENLIEMTQQQTYDCLSTKARSAMMDRLAFLLKKSGMPCHLCNRCKTLSGCSDVTWMCPQCKTYTESTANRNSVTGISTPNMLNTQNTNNLQIGNHGKITDQQNMGQMIHSNVSINQNLQQQPSQGIGQNPGYTIGSNAGNSPSHYKPGTMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI71</accession>
    <name>A0A0N5BI71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barrier to autointegration factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI71"/>
    <dbReference type="STRING" id="174720.A0A0N5BI71"/>
    <dbReference type="WBParaSite" id="SPAL_0000565300.1">
        <property type="protein sequence ID" value="SPAL_0000565300.1"/>
        <property type="gene ID" value="SPAL_0000565300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000565300.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10318" checksum="A08C1F433C52B471" modified="2015-12-09" version="1">MSPTKKFQNFTERPMGDKKVKAIPGVGNVLSKKFRDGGIVKAFQLYGMYLFMGKDDNEFKEWLKSQFHVDAVNIDQITESISEYARRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIL8</accession>
    <name>A0A0N5BIL8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyco_hydro_19_cat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIL8"/>
    <dbReference type="STRING" id="174720.A0A0N5BIL8"/>
    <dbReference type="WBParaSite" id="SPAL_0000579800.1">
        <property type="protein sequence ID" value="SPAL_0000579800.1"/>
        <property type="gene ID" value="SPAL_0000579800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.20.10">
        <property type="entry name" value="Endochitinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836:SF1">
        <property type="entry name" value="GLYCO_HYDRO_19_CAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836">
        <property type="entry name" value="PROTEIN CBG09520-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894327" evidence="1">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 19 catalytic" evidence="2">
        <location>
            <begin position="182"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000579800.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="52310" checksum="3DA87BB5B0E84CA5" modified="2015-12-09" version="1">MNIFCVVVLVFIFIFYVFCECPKHEVYGEYPKDGCKIARDPNKMPRSPIEKWFRRKIFNDLFPRANLGLGPHPCLPYSYEAFIIAARYFPEFGGSSQKVNGVDKEVIQKRDVATFFAHLIQETGENNYNYFNVSLPEDEALKCFYQGGLYHWFEGGQNSKFLRPNKTYTVEDGEYCTDKGRYCSETPDSKFWYPCNKKKKTIDGVEMNKGCYFGRGPLQLSWNYNYGQFQYWLHSQKIDVDLLNNPNLIMTKMDPPLAMLASMWFYMTPQPPKPSMHSIITGKWLSSLKNRKKGYKGSVFGPTSLVINNECSGEEIEEIVGGAGENRRIKAYKWFTSYFNVSAGPEKTITCKNMVENFEGIPHNHSWQPNWSTMWKSEPCDCTPTQYNGALPYYDPKVYGDKDYDVINEQNRLRCVYSMYKNPKRFNIDESNSPCIKFKVKLKLSKYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJH3</accession>
    <name>A0A0N5BJH3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="13">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJH3"/>
    <dbReference type="STRING" id="174720.A0A0N5BJH3"/>
    <dbReference type="WBParaSite" id="SPAL_0000609900.1">
        <property type="protein sequence ID" value="SPAL_0000609900.1"/>
        <property type="gene ID" value="SPAL_0000609900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23617">
        <property type="entry name" value="TFP_LU_ECD_Daf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF72">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894626" description="Serine/threonine-protein kinase receptor" evidence="14">
        <location>
            <begin position="28"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="267"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000609900.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="69255" checksum="86FAA3A90336C473" modified="2015-12-09" version="1">MKKFKNTVLFWCFLALILISNNNEVSGGLIKEYRTKVDQLQNGQGSQTVYIDEKGRSFIWCDSFRKNECLSGNVTECTTKERCYRENHEHTISCSAAYVFDTIDRFNFTIHDDALQAKGCWSQEHAHLECLDIKECVLKEKIRALDTNKSALFCCCFESNCNSQEFLRYEVVSLQEDHELNKSLIKKDNFMSQEELYHTPTTMILASIFILCTIILLCSPRIIRNIKKNIHETKEKEKSSVSLEIVDNGKKPLLVEKEKPRSCHKQIEIIEILARGRFGEVYRGIYNGQVIAVKTFNQDNAASWIKERDIFTNEFVKEHDSIVKYLGMDYIKTESSISYRILLEYHEKGSLNNYLNNHKLTFYIATKMMMSIINGICYLHEEINGGDDSKPTIIHNDIKSKNILVKNDLSCCISDFGLSTTCLNGRMPSDEVLQQVGTKRYMAPEILEGATEFSAFAFIQVDIYGAALVIWEILSRTFIPGMEKLSDVPRYILPYEDKVGLNPTIGEMRNLVVMKKVRPEFNEFIYKNTLSSKIVSVIEDMWDSEPHARISAGCAKSRITTIFEQFLPVPNSDGLFTIPDCADIISSDEILDYNSSAETTLMSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJR5</accession>
    <name>A0A0N5BJR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJR5"/>
    <dbReference type="WBParaSite" id="SPAL_0000618600.1">
        <property type="protein sequence ID" value="SPAL_0000618600.1"/>
        <property type="gene ID" value="SPAL_0000618600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000618600.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16971" checksum="92D5B826DC79FE00" modified="2015-12-09" version="1">MKVLTILIICINILSCNSYYYVIRNYYSSYWKVHAIVLPECLLDNGNKSKIVENVTATLQVQSSQTVSNTSTCGKNLTVAKEHVGDFYIKHGGMITVKYFYQTSEKSFIRKIPDDCEIRAWEDKKGNYYCRFEDINPNKTIITKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM05</accession>
    <name>A0A0N5BM05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Saposin A-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM05"/>
    <dbReference type="STRING" id="174720.A0A0N5BM05"/>
    <dbReference type="WBParaSite" id="SPAL_0000695100.1">
        <property type="protein sequence ID" value="SPAL_0000695100.1"/>
        <property type="gene ID" value="SPAL_0000695100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894515" evidence="7">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000695100.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="57847" checksum="241585F3FB831FE9" modified="2015-12-09" version="1">MLYYLKFKFSLFLFLIWIVISQQLCTLPPAFWCDNEEVALKCTGSLSYCQSYKKNVEENKNKISFKTSFGPLCSDSIAFIFKRLYPTILASPQALSQFDFEAVAWGVSKRLENGKIQCHHGKKECEYNTLFSCSHYRIKDEYKRVKFFICAMKYVVQYSKVKDIIKKCGPSKKIMSRYEGNKISYCVKGSEGKDLQNKAEKETAKIINPPIFIPQILIGNNDKTMDMQIYQLLLNEKPKMWKKQLENIKSGGQKINNCTTPPDFWCSTEKLSSDCFNNEMCIGYISTIQDKKIDFVMLYDPEEPVTQRMLSESFQNNFLENNAYYIKKTYNFEMKPKWNDWNRDECTRKVSKGCRNIAVYSCISKHVFDHKISTNLQICLMKAKLTRNVYAFDALKNDCRGKYLSIHKTIKTNIENCMKTNDFISAIKEYTDYIDKLTPDKVTKEPWLLINDFSLNSTQEYIPILDKMVCTWYYGYNHDRDFCGRCQYEESRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMX7</accession>
    <name>A0A0N5BMX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BMX7"/>
    <dbReference type="WBParaSite" id="SPAL_0000726000.1">
        <property type="protein sequence ID" value="SPAL_0000726000.1"/>
        <property type="gene ID" value="SPAL_0000726000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000726000.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18081" checksum="81AAEF503543A870" modified="2015-12-09" version="1">XTELRRVSDFGTFLRQEKKVTTTVMSILICFTLTQTPSIIPTIISLFGIKNKKLSIMTSILNLLVIFGKVLNFVLFCTASVHFRRRTITMLQGLLCRNYSKKFSNINNSYNYRIVENQSRNISIAGRNPSTSTTITRAGFGHKTSFINNNKTTKANPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNC5</accession>
    <name>A0A0N5BNC5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel subfamily K member 18</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNC5"/>
    <dbReference type="STRING" id="174720.A0A0N5BNC5"/>
    <dbReference type="WBParaSite" id="SPAL_0000740400.1">
        <property type="protein sequence ID" value="SPAL_0000740400.1"/>
        <property type="gene ID" value="SPAL_0000740400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF347">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="425"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000740400.1"/>
        </source>
    </evidence>
    <sequence length="774" mass="90977" checksum="3B866FE825EC1D73" modified="2015-12-09" version="1">MKKRRHSNMDRLRLHKKNHFSLAEKRRRSSSFASPFDAFSSINTLKCVSEHLFINCVLKINQENSENIIMDERGKLKEPPALSASRLLVPSNIMDNWNQHKTLFGDKIKILGNNFDNRQGFLKKFSLYLQVFYERSRLRYFIPIIILLAYSFLGGIIFYTIESPAERVALLEKEEYMNKEENKVLDVIMEIEDELKYFFIKAKNITVYYYYLHEYRKFAMNKLNQRIYWYALESYYLSDQEAFKSSLLHPTKPEPHWSGYFKKPYGQIYALKNYTEQLSLRCWEICAELTGKEKAKIKLKEALKLFHQWTGLEHILSPTFTFRNSMFLAVTTYTTIGYGNITPKTNKGRFAVMIYAIVGIPLVLMILHKLGRYILLALEYTWDMTIYAMEAVGGLKNGEKYKSKILDEERDSGIPVLVAMFVAFGWMFMCAAAFLFFEKDWDYFKSFYFFFCSLTTIGYGDVVPTSSDDMFIIFFFIIIGLSLVSMCINVVQLKLEQLVEEILLAMMEEYTGDLEFGFSGANLKARLGVVDMWKIWKRRRSRKKKEKVAKAKDIVVEDVKHGIEKKTSFVNKNFREMMPFGKRRRVDEIMQEIQKRLVQKNKAVQTDPVIIYRIDEKPFENKVCFANKSVGSSSLSLNKKPELGSIGENLDELPIKYKRDITYRHNQTEHEIRRRPVLPPSYGIQYPINEEGYQYNPTRRWTFVETGKAPKGAPRGLAAHYMYRDQQYPHSDELEYLVQEIDTRLKECRKKLLEKQKADALKNRRNTQTSETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNN2</accession>
    <name>A0A0N5BNN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNN2"/>
    <dbReference type="STRING" id="174720.A0A0N5BNN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000750900.1">
        <property type="protein sequence ID" value="SPAL_0000750900.1"/>
        <property type="gene ID" value="SPAL_0000750900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="68"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="286"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750900.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="55784" checksum="EB06FE178F7C3787" modified="2015-12-09" version="1">MWASIVKGKKRNGLKKDISNNKNHQLIERRLNRTNEKINTLKRNLWDYEVNKNVKKSFDIKMSADRIEERLYKTLLNSERYEKDVRPSLHHSIQTNVTFGFLLNQIVEMDEKNQILTTRCWLNINWFDPRLTWNQSDWGGIDILYVPHQKLWKPDIMLINNAVTEYFGSLVSTDIMTTSKGNVTWLFSALFKSVFHLNVKYYPFDDQECELRFASWSHQQSEIDLRLITNQGDLSFYMNNSEFSLLNMHAYREVLHFPTRNNVTWPTIVIKIKIHRRPLFYVFNHVLPCALISSMAVLGFLMPPETGEKINMCITTMLSMGVYLQSITESIPPTSEAVPLIGIYYLSSLSIVCLATVVNVITLNVHRSGSTNQGRSIPYWMHKFILVYLAKFLFMTIHEPDSVALTKIARTNSSIRKKSILRDLKKAKMLSDREKLDNEDCECLKKQENEDFSNPNFKNKNYVINIFKKLFLYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP80</accession>
    <name>A0A0N5BP80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP80"/>
    <dbReference type="STRING" id="174720.A0A0N5BP80"/>
    <dbReference type="WBParaSite" id="SPAL_0000770700.1">
        <property type="protein sequence ID" value="SPAL_0000770700.1"/>
        <property type="gene ID" value="SPAL_0000770700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF352">
        <property type="entry name" value="SYNAPTOTAGMIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="108"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="242"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000770700.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44557" checksum="026B557BF48015E5" modified="2015-12-09" version="1">MLESCGYFISCNPIIRIFTICLPFKSSPTGRENKNDSNTKLVTPPFVPISSSKVSIQPYNGDLKHILEKNDSTESKNTASSFISKKLSRTLFSSVSRDSSTSDTPIHPYGEIRYRLDYDFSTNKLAVTIVQCRNLPAMDRNGSSDPYVKLCILPEKKQKFETKIKRNNLNPVFDETFLFNIPFNELYNMTLHLLVYDFDRISKDDRMGQLLIPLEGVDFGTTTDKWSPLEKPESDNDSKDARLGDICFSIRYRPTTGILTVTIMEARNLKKMDVGGSSDPYIKIYLHHGKKMLMKKKTSIKFKTLNPYYNESFQFKIPPNILQNVYLEVSVWDYDKVSKNDFIGHVIVGSENITQQSITLGAHQQWGEMLITRRPIVRWHTLQAKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPW6</accession>
    <name>A0A0N5BPW6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fanconi anemia group I protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPW6"/>
    <dbReference type="STRING" id="174720.A0A0N5BPW6"/>
    <dbReference type="WBParaSite" id="SPAL_0000794100.1">
        <property type="protein sequence ID" value="SPAL_0000794100.1"/>
        <property type="gene ID" value="SPAL_0000794100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000794100.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25199" checksum="4DD798ED94C7CD93" modified="2015-12-09" version="1">MNIERVKCALSLFSKAICKVLDCTQYTTEIVIKLQNVIETTLIYICNIYSYEDVIVLGNGIFELSWLLPDKNMILDLLIDQIVVSIDNNISLKVILHLVGKLFDRLYHENTKSDAHNILLLVVSTMSKIKLINSFEKSIYVMRCLFCAGNPNECVRSQIFWNVLDIQNVSPGYRKYLFTSILNALDAVKIDKTFLINSMKRVIKGSSEEVIDINRLHAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQW2</accession>
    <name>A0A0N5BQW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQW2"/>
    <dbReference type="WBParaSite" id="SPAL_0000827100.2">
        <property type="protein sequence ID" value="SPAL_0000827100.2"/>
        <property type="gene ID" value="SPAL_0000827100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="202"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000827100.2"/>
        </source>
    </evidence>
    <sequence length="343" mass="39046" checksum="002CD59E400B704D" modified="2015-12-09" version="1">MHILYNSYYIKFVILFISFSKYYTLGSNVENFKSPSIDLVQNDLSSKNFINQDSLVHSISGNNEIKYLIKRQADGKIGQNKQKIAAKTKSKTKFPPKKPLPSKPKPQKPQVMKTTNVRTTKKPTTAKKPLSKTTIKPSFRTTTKKRLTPTKKTTLNKTTQETTRSTSTVTTTRKRRPKPKTTPKPDKYAHLKSKVSSLYIFTNILQILNEINDLRLKHQAQNLTVDPVLAKKAQYHAEKYAAQSIVPFYEDNSIKTLIYTTRIGDAFNPMSLWTGGSIFVDFEKPDQFEIDIPFTQLIWVSTTSIGCGISEDKSRSEILTVCLFYPKGNIPGQYSKNIFKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQY9</accession>
    <name>A0A0N5BQY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000829600.1">
        <property type="protein sequence ID" value="SPAL_0000829600.1"/>
        <property type="gene ID" value="SPAL_0000829600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894745" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000829600.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11200" checksum="F837505E37D0A89E" modified="2015-12-09" version="1">MNSLSIVILVGILINISYGYTHNCFETTTIKCTVYLEPGEAAYKTFLDSLEDSVRNRFDLLTGETDPDLIDKANDIIKKYVSQESIVSQLTIINLKFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRN0</accession>
    <name>A0A0N5BRN0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cir_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRN0"/>
    <dbReference type="WBParaSite" id="SPAL_0000852600.1">
        <property type="protein sequence ID" value="SPAL_0000852600.1"/>
        <property type="gene ID" value="SPAL_0000852600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000852600.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="17634" checksum="48857583F17A83CF" modified="2015-12-09" version="1">MTNITEEEWENYKKRVTRIESERARRREKEEARRLSKEKTRKSKEEERKELKDTFKRLPQGAQNYLKNRKRTNKQKAGQEVNKGNQREWHQLHKEEKEEFKRRHQSPRPGENYSQYYQRMEDRKRRIEVKRKRINNNEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRS5</accession>
    <name>A0A0N5BRS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRS5"/>
    <dbReference type="STRING" id="174720.A0A0N5BRS5"/>
    <dbReference type="WBParaSite" id="SPAL_0000857000.1">
        <property type="protein sequence ID" value="SPAL_0000857000.1"/>
        <property type="gene ID" value="SPAL_0000857000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894764" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000857000.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11133" checksum="98C30A2A7D4322B9" modified="2015-12-09" version="1">MRNFIFVILCSYVLLISLTTIRGDECDGETQSCKCCKLDCWHSKAEQATDELGHIPGENNEEEALNTLKLIKKCVTEKCTQLCKAQFRPRPFFNLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUZ9</accession>
    <name>A0A0N5BUZ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000966700.1">
        <property type="protein sequence ID" value="SPAL_0000966700.1"/>
        <property type="gene ID" value="SPAL_0000966700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733453" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="30"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000966700.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="41185" checksum="7184E1187BE15F49" modified="2015-12-09" version="1">MLCFIFIMFFYNCIESSIYMDDNINIREKKAIIIDRKKMFKSEIIRYHIDKSLDSQIIEAVLSYLNKKTCFSFIKTLREDKTDLKFEYGPNFNSSLGKTDNKTQIITIGAKNPSKVQVFRFVLRQFGMDFEHNRYDRDNYVNVYLKHVKQQYFSFFKQKPYYLASTYGINYDFSSIMHFSKREFTENFRISLEAKDKLMDATMGSSLKPSFNDIKLLNRHYCKHKCKIKLECFHSAYIDPLNCQNCRCLPFYTGTHCEKFSPNHYPICQRNNIFMVDNRKRLLALTLYGDCHYIFVARPGKRVLFKTAESRPKWYPGIGGPEEFIEIRYKSDKSVSNKILLGGVTHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVD4</accession>
    <name>A0A0N5BVD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000979700.1">
        <property type="protein sequence ID" value="SPAL_0000979700.1"/>
        <property type="gene ID" value="SPAL_0000979700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="155"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000979700.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33119" checksum="BCECAA2CF756947D" modified="2015-12-09" version="1">MENVLSSKNFINQDSLVHSISENKHQRKRQADKRERNNKNNSISKKRNKKRFQAKTPLARRSPVRKTPAPRPPNRRLPTKKPGSRPNPPKRTTKKQITPKKPSPGGPIKPKPSVKPKPKPSVKPKPQPPVNPPAKPQTAEPTTTTTTVKPDKHAALKTKTISDINALRRKHQASALNFNQSLAERAQKIADKSHRRLDDIDDDSVGLVFYPKRFEDKFDPLSFWTIGTQNIKYDNLDEHTVPLNFARLVWVSSKEIGCGISELDDNAGIITICLLSPKGGIPGRYPENIRRPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVH9</accession>
    <name>A0A0N5BVH9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVH9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVH9"/>
    <dbReference type="ESTHER" id="strea-a0a0n5bvh9">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000983700.1">
        <property type="protein sequence ID" value="SPAL_0000983700.1"/>
        <property type="gene ID" value="SPAL_0000983700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733535" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="42"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000983700.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="76257" checksum="A26E08E540230C41" modified="2015-12-09" version="1">MFIKKFNISFTILLILFLFISNKIEGKSTIKSEDSLIDQLIVRQTSNGLVLGRKSIPTDESVDGYVFLGIPYAKPPVGLLRFQVPEDPEKFDTIHNGRSYGNACLWNSTVTNQKPGYTIMSEDCLQINVFTNKKCLLTPNCSVAVYIHGGAFNFDSPMILNESMIIQNFASPGRDVVFVTFQYREGIFGFANFNYKLNLSVGTNVGMFDMLQAMKWVKKEINNFGGDPNKITLTGHSSGSVSASLIYVSPKSKGLFNQALFMSGTRPNSLFVDGNQNISRIIAIEAGCAFDITNWNDINDVEGVIKCLKNVDGFNLVSYQALVETFGLRLQGPYQDFGPNSFFEKNLQELVVPDVNLMTGTVKEEQSDGLVTIESNDNGIVFVNKQKIEILCELIFTMVIVENYKKSIEACVNEYSSDLYRAKHIIDDITFFLQHLRDAKVGAKTTSKVYLYQFNYSVPTGVIDLKNDGIIKPKDSPRHSDELVYLLGLHMGTFGDKERVIAKKFSQMIVDFINKGNPNSDEVKFDVFDPSLNNYFVIDFDDNYLMPGMENNYHRRADTFWNEIMPKIEGEVAFNVLEGKAIEMTPLINELEDGIIYTPIYYPQSYYINTTMPERGEIKSLLTTSTKPIVKMPESFGTVATISMVIFGILIVVLVLSCIKKYLKHLERRKYKRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWW2</accession>
    <name>A0A0N5BWW2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWW2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWW2"/>
    <dbReference type="WBParaSite" id="SPAL_0001030100.1">
        <property type="protein sequence ID" value="SPAL_0001030100.1"/>
        <property type="gene ID" value="SPAL_0001030100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001030100.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42383" checksum="167D178E372DECEE" modified="2015-12-09" version="1">MTINIESGLVIGSRFKIIEKIGEGGCGSIYTARDINTRIRVAVKTARNGTDEGNILKIEASVLKRLEGRNNVAQILAEGKKESFSYIVMTLLGSSIAELKSKCKTFTSSTLIRLSIQLLYGIKELHEIGFVHRDVKPDNICIGRKGGALKVIQLLDFGLCREYIITINGKATLREPRPSKVLFRGTPIFCSIDAGNGNEQGRHDDLWSMMYVIADLISPLPWRFLGTCREEITKYKMETKDEHIFPGYPEFVEITKYLRSLTYYKRPDYGKIFLVLKTVLASSGSLFSDPYDWELKNVVEASIEVDEPDSAYMNQPMQDRKSQRLGSKSCSSKTRTIFNFLRSKKVNVSLLPEDLKILEECYSLENFEKTNMCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXF2</accession>
    <name>A0A0N5BXF2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXF2"/>
    <dbReference type="WBParaSite" id="SPAL_0001048250.1">
        <property type="protein sequence ID" value="SPAL_0001048250.1"/>
        <property type="gene ID" value="SPAL_0001048250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052860">
        <property type="entry name" value="NRL-GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47521">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001048250.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38016" checksum="D9C9E19AF99CA4AA" modified="2015-12-09" version="1">MLEIGSLEWLTQNIHSTSIYRNAIINKKLDSSVDFIFIIIIIFSLFNLIILFFYNFGIPKYTAYHKNIKLFAILITTASSVVTLCHIVYCFFYLMNILTPIENFYLFATKLTFATFVGCKPIIFGYERSIAIKNALIYDKAGMNYIYIIISVFIPNYIPFVIMGVQNICALIYFQKLKHILNKQWNEEIKNKTSLSYRFQLTENVKTFNIVQVVLLGVSCVVMSAIPLFILADSHFFDINIASIFFDVSSTFITTFLLVFFGVLHTQMLKKIFCLYKLNVPRKSLTVSSIREINNKNTEIYFNQMRLEWNKYNLIALILEKSMHSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXS0</accession>
    <name>A0A0N5BXS0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXS0"/>
    <dbReference type="STRING" id="174720.A0A0N5BXS0"/>
    <dbReference type="WBParaSite" id="SPAL_0001059000.1">
        <property type="protein sequence ID" value="SPAL_0001059000.1"/>
        <property type="gene ID" value="SPAL_0001059000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000016">
        <property type="entry name" value="Derlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001059000.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27232" checksum="A43C09195BC8D2CB" modified="2015-12-09" version="1">MNEILQSISLIPPVTRTYLGLCCFVTFLVQFDIITPFHLYFNWNLIVKEFQLWRLISSFLYLGSFGFSFIFNLLFSYRYSRMLEEDSFAFRTADFVFLYLYGAVFMIVCGIFTNTIFLGQAFTIMLVYIWGRRNPDVRLNFFGALTFGASYLSYFLFFFSILMNQSVVGDILGISAGHIYYFLEDVYPREHNGHRILKTPSFLKRLFDPAPLAEVPVDERAGGMAWGANGDADDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXV4</accession>
    <name>A0A0N5BXV4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXV4"/>
    <dbReference type="STRING" id="174720.A0A0N5BXV4"/>
    <dbReference type="WBParaSite" id="SPAL_0001061900.1">
        <property type="protein sequence ID" value="SPAL_0001061900.1"/>
        <property type="gene ID" value="SPAL_0001061900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF151">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001061900.1"/>
        </source>
    </evidence>
    <sequence length="881" mass="97914" checksum="2EAD9C633B645FC8" modified="2015-12-09" version="1">MDIGKDSVKEDDEDYINGQSLGAETQSAPGDLAQLPGTSSKESLDFPLGQPIISNTPVNNDNSFNKDIIASYRSPGPNTSRITPRPKGHYRGTRENGFASGPPFPTTPRREPTWLSPEERQKKVQQIELIQKQFDNITKEAQCGIKDWRPKWIQRFANRKVMLILLCWFCTIQGMLINGLVPSSLSTIERRFQINTSTIGRIMQFYDFGYVLFCIPVSYFGGRHSKPLVLGIGLLCMAIGSFIFSSPHLITDAYTSTYNSEDAALSKCSSENSSSLFNMVNEQNTVNGTNSMHSPDALALKSCPSPENQPGTFRYVFLFCLAHFLHGVGATPLFTIGVSYIDENVGTALSSLYVGIFYSFAIFGPALGFITSSSFLQYHTDFLQPGQAFAIKNLDESDPKWVGAWWVGFQLASVLMLVAVFPIISLPKVLPESLQWHKNRLQEEALAGGQRKRTPECCGVPTSGKTAAVFGSLMQMDEASASNVLAEQMPALKSKNGPIWYQLWLDVRHIPIAIYRILSNGSYMLITLAMAVDGMVIAGASTFMSKYLEGQFSVAPSKANMLIGVIMVPMAGIGTMASGYIIQHYKFNCVKSLKFCIALLLASLLLTPMFFIYCDHDQLTGVERPYMDKNDKVFLNITLNDDLLPMSLRSTCNNHCQCLDSEYHPICAEMKNESQIPFYSPCFAGCEEKYDPQRKFYTNCKCVPQDVKQVKKGYCESKCTGLFAFLTFFAPFCLFTFAVGVPLISVVLRTVEYAERSFALGIQWIIVRVVGTIPAPVVFGWIFDVSCTRQHLDPCSGEHGSCMLYQNKLLADLFFVFSIIGQLITMVLLISVLIFFAGSMRDDPDPNVINQKTDIPSLLNDDDEKKDQPSENVPMLISNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYA9</accession>
    <name>A0A0N5BYA9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein D-ETS-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYA9"/>
    <dbReference type="STRING" id="174720.A0A0N5BYA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001077000.1">
        <property type="protein sequence ID" value="SPAL_0001077000.1"/>
        <property type="gene ID" value="SPAL_0001077000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000996">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF182">
        <property type="entry name" value="SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="138"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="469"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001077000.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="64877" checksum="EA25B95A6CC29381" modified="2015-12-09" version="1">MNSSVMTLQMNQMNENSWLTSPINNHQNAKIEFDMQYDRLSNDNNMFMSSPDSSKTSCNSDTMTDDIFAELETIDKERTKPINNYQMPYTIQKSMTIKEECNGQYYKTIPYQNSNINMQNIENNNNGVDLYRDLILRHLVQDINSTCMRLYLPNNPAVWTTQETTKWISEMCTQFRLKIPQNLFLSGRILLSMTQEDFLHKAPESGETLYAQLQLWKTAYDSCNQNVNILPNNFNSSLNTTTTITNNNQPNRKEVTISWQEQSPSLSNQKRPLYPNEEDITNKHYYQGSNQHLQHQLSPHQTNFVINSSPVPITNNNHQYCSSSTGTLSSSPEYGRNHNFEMYFSQNIPKNIQSNMISPPNSASSSSNSSVYNEEDEFSNLIQSNNQQMHYNSSPIAEYFQGNIPMSMSDQKHPLYNCENIKQTSNIINENCLNNNIEVFNNINVSNDVVKINQDQGNPTTYQRSSGTVHLWHFIRELLDQPNEYSSCVRWVDRNEGTFKIESSHHLARYWGIRKNRAQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKFLPPYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYZ9</accession>
    <name>A0A0N5BYZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transcription factor HNF-4 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYZ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BYZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001099500.1">
        <property type="protein sequence ID" value="SPAL_0001099500.1"/>
        <property type="gene ID" value="SPAL_0001099500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001099500.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47198" checksum="51B19269741F7B28" modified="2015-12-09" version="1">MSQRRKVPEGQLCDVCNDKATGYHYGVASCNGCKTFFRRTVVSDLKFTCQFNGNCDIDKNVRCACRHCRFEKCLAAGMDANAIQNDRDRISSSVKIKREETPSNPNMPYNTLVDSYNFKRELNFENCNPDSSIVENVQDVEIMNKLARIETLCNDLRKKAIADDLTAKEILPRPSLLYETSKLPDDAGTIFREFYPASMNDVQMWNIRELRLCLEWVKVFPEFRDLSSDDQFALVHNFAFTFNILNRVFYSIDNGEDKIVYPNGAYILRQPQDEVRIPGCRSIYHRQMDEIMIPLRKLGVDMKEFAAFKFILLFNPDASDLTQFAKALVEGTREKYIKILFNYMICKNGVNEGGSRYGKLLLMTSSIQQIIAQNEENMQVMEVFGHFWRINQFVKELCMKARENDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ01</accession>
    <name>A0A0N5BZ01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone chaperone asf1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ01"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ01"/>
    <dbReference type="WBParaSite" id="SPAL_0001099700.1">
        <property type="protein sequence ID" value="SPAL_0001099700.1"/>
        <property type="gene ID" value="SPAL_0001099700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001099700.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27539" checksum="0FD8C6CD1E0D2659" modified="2015-12-09" version="1">MANRIIIEDVTFHDNPSKFTDKIKLSIKFQTVENIESGTKFELVYVGEPSSRNYDQSLDTIEFEDIPIGIHTVTLEVDHPDVNKIPPKDLVGATAIILDCYYKNQLFSQTSWFVTVEYTDPELVENPPLTPVIEKLARTIDTDDPRTCLHTIKWNESDEILVVPNVPVKPDVNDGEEIVFSAADYTEEELKKLENEAELYESSEDDDESIDLSDEDILDEEEELGDMSKDENEEDETPMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZE2</accession>
    <name>A0A0N5BZE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BZE2"/>
    <dbReference type="WBParaSite" id="SPAL_0001113300.1">
        <property type="protein sequence ID" value="SPAL_0001113300.1"/>
        <property type="gene ID" value="SPAL_0001113300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF7">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001113300.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10945" checksum="9BD81F65DEE999FF" modified="2015-12-09" version="1">XKFLGFDGVFCMRMISAHAGDIMATELIVALWHNFNDRVRKSPIEMFEGGVSQSPSKLDANFKTWLLGQTRANPSFDGSNPTRGKKRRKSDGYFTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZT5</accession>
    <name>A0A0N5BZT5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZT5"/>
    <dbReference type="STRING" id="174720.A0A0N5BZT5"/>
    <dbReference type="WBParaSite" id="SPAL_0001127500.1">
        <property type="protein sequence ID" value="SPAL_0001127500.1"/>
        <property type="gene ID" value="SPAL_0001127500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09331">
        <property type="entry name" value="LIM1_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09332">
        <property type="entry name" value="LIM2_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09333">
        <property type="entry name" value="LIM3_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000011">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000017">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000094">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000141">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047944">
        <property type="entry name" value="LIMS1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047946">
        <property type="entry name" value="PINCH-1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038003">
        <property type="entry name" value="PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001127500.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41007" checksum="C4F1B184F5297469" modified="2015-12-09" version="1">MVANIGHEQNNMDELGARFDNLFCVRCQDGFELNEQIVNSGGQVWHSECFVCAQCLLPFPDGIYYEFDGRKYCEHDFHVLYAPCCGKCNEFIVGRVIKAMNLSWHPKCFTCELCSKELADIGFLRNAGRALCRECNEREKAAGSGRYVCHQCHAIIEEEHIKYRGDSYHPYHFKCTSCSVELDHTAREVGGNLYCLRCHDTMGIPICGACHRPVEERVITALGKNWHVEHFVCSVCEKPFLGHKHYERKGLAYCEEHFTKLYGSTCFRCGKSCGGETFTALEKTWCLKCFGCHLCDKKMDHKSKFYEFDMKPTCKKCYDKFPTELKKRISDRLKERNQIAVERQRRSMSPTFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1P7</accession>
    <name>A0A0N5C1P7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1P7"/>
    <dbReference type="WBParaSite" id="SPAL_0001191900.1">
        <property type="protein sequence ID" value="SPAL_0001191900.1"/>
        <property type="gene ID" value="SPAL_0001191900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001191900.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18123" checksum="C22D6218E3093975" modified="2015-12-09" version="1">MQEIDEIDSVVKDGRGVVGTCDPRKYAESRRVAQVFQELSDKVSGVNVPTVKKRRRMTGRFPRQEDLEGKTASPLRQSSDLKAKGCRFVGRVVSPSACVPQPSPVAQEDFCATTQDIKQESLEKKQESLEKNGKTKAPRTSKNSGDGASKSMHKAGRRKRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2I4</accession>
    <name>A0A0N5C2I4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2I4"/>
    <dbReference type="STRING" id="174720.A0A0N5C2I4"/>
    <dbReference type="WBParaSite" id="SPAL_0001219300.1">
        <property type="protein sequence ID" value="SPAL_0001219300.1"/>
        <property type="gene ID" value="SPAL_0001219300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001219300.1"/>
        </source>
    </evidence>
    <sequence length="893" mass="101485" checksum="BCA14E23740B8DF5" modified="2015-12-09" version="1">MLPRIFKRSDTKKQPAADNHQVFLNQYNALKSNWLQEQKNAKSLSSDEQHQISLIQNNALKMLINNLRLDEAKYLREYPVPTLTDNDMNLDLQPFEKELDATFRKEIGKDQLAVYYVPSLIAKDKGLIKSYYQQHLNNRDSSSTYTLLSTFENIVELMELDGHRAMLGASIHPPKQLGAPIGTYIRMFENYVLRLDGLRMDSNEMMDNAPLNNDRRRQFINGLDSNIRIIVPQPDYYTPWHAFTQAYSSGYSRLYPNKPLFGKAPHRNNNTFSTNNESGIETCENNAKAFKKIVPCELPKTDKVQEDQKFEIIRLRGDVELRDLYIKRNNEEIASLKEQLKETKDYLQTLSLSTTGAQNAALNLKDSHTAHIKEISSSAQEKLEQAIQLEKEKCEKQRQNDLLEWKIRADEIEKDYEKKKNEEIKIIKQIFDEQMTELKTSIGSIKTEAMDTGEPDVLLQKLEKQSQDIITLQQMLRIKQEHTTTASTITSEHCTAYNNFVRFIDNIKHLDLYNAMLTLPSSIASLLTFLSTLLGSRMISTVKQKSSNSHPKTRKIIKQPYHQPLTHNTTSSNWKFGDGPLLATVNSILHEAIAKVVIDIDNTEVLTLIDTGATINVISKVILEMIPSNSFKRLPIDNIVATSANGTKIKIIGKALLTLKLGKSKYVITCYISPDISHDLILGQPGLAEIGDLKISWTNGTVTLGISWTNGTVTLGTHTLELHNAYEMILPVDTLLNPKTHSILNPEVLSAPHLNEKDVFTIVNPRFKGNNLLMTYSQITPVLDGKVNLIIDNIGNNPVMLKKDTLLGHVTLIEQLNENELRITDDGYDSDEADIVDRLPPYPSKIKSKITSKNDFLQLVSLDTSELTDKNILDLKNILWKFRNVFHEFNSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2J7</accession>
    <name>A0A0N5C2J7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2J7"/>
    <dbReference type="WBParaSite" id="SPAL_0001220500.1">
        <property type="protein sequence ID" value="SPAL_0001220500.1"/>
        <property type="gene ID" value="SPAL_0001220500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895341" evidence="2">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001220500.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28040" checksum="AA0BEDA4531F3709" modified="2015-12-09" version="1">MKFLISFLYLSSFISVSYSLSDSPTIINNRVPYLKDRKEDNLGPIKEAFEEIVKDLLVFSKKIAETYKTKSVKDDDTSKANIVKAIQFHLRTINLIADEVDLKLLPLLQQASDKSKRPKRSPNVAAQWNGEIFWKHPSVKISPSYKKQDSSSFTTKDNSIKDNKVFELHYVTDLPYIPLGETVKIPEKLTPSKSDYHAHPGRSKPKTTNYVSMSVSMKEGGKHSPPKSPLPLSPNPIMMAPRTMIYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2U8</accession>
    <name>A0A0N5C2U8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2U8"/>
    <dbReference type="WBParaSite" id="SPAL_0001230500.1">
        <property type="protein sequence ID" value="SPAL_0001230500.1"/>
        <property type="gene ID" value="SPAL_0001230500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="90"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="128"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001230500.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50326" checksum="8351551EBF3D87B8" modified="2015-12-09" version="1">MYRRVRRQAIPMRGVQQRPSFIKRIGYAVKRNFLKLKAMMNPKLYQGDVLLTKDQSQSILQQLRNKFFKRGFRLPSFGFGVSNVTRIKRRVMSNLAYKWDGAIPFYVEPNINQQIVIKALLEIQRETCIRFKQVGSAKVQSSGIRYFVGQGCNSYVGRIYKDRFQDISLGQNCYDLGIIQHETMHALGFFHEQSRLDRDKFVTIVRQNINPQQMHNFDVVDVDDGLDYGLSYDYTSIMHYGATLFSINGQPTTVPNDNNYKMSMGVGDQASFLDYKFLNLHYCGRVCNTRLQCSNWGYIDPNSCTRCKCPKGFDGQFCEKVAVMPGDCGQPAFKATSSIQEINVKGFKNCYFAVSAPQGQRIAFKLVFSYISPGYVEACTIQNSVEFKYYKDKSITGARFCLKDMETVRVTQNNYLLIAYNSNRSDNEATILYKAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Z2</accession>
    <name>A0A0N5C2Z2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="13">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Z2"/>
    <dbReference type="STRING" id="174720.A0A0N5C2Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0001234800.1">
        <property type="protein sequence ID" value="SPAL_0001234800.1"/>
        <property type="gene ID" value="SPAL_0001234800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001234800.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34946" checksum="711F40297DAAB131" modified="2015-12-09" version="1">MFSDSSDTMVNNDSVSLITITTIIGIVVAGIAYFFGRRDDRKKVTLVNSEEKYNLKLIKKKEISHDTRLFTFALPSEDECLGLPHGQHVNLIAKIDGKTVIRSYTPVSSDDDKGFVNLLVKVYFKDVHPKFPEGGKMTQYLESLQIGDSIDFRGPQGLIVYTGHGKFDVSPKKNSPPVKKEFKEIGLIGGGSGITPLYQIIKSILKNPNDLTKMYLLYANQSEDDILLREEFDALAKDYPHKFSVWYTIDRANDGWKYSTGFINEEMIRKHLPSPSSSNGILMCGPPPMIEFACLPNLEKVGHSTENLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C308</accession>
    <name>A0A0N5C308_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C308"/>
    <dbReference type="WBParaSite" id="SPAL_0001236300.1">
        <property type="protein sequence ID" value="SPAL_0001236300.1"/>
        <property type="gene ID" value="SPAL_0001236300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001236300.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40053" checksum="D5ACE20A244CA254" modified="2015-12-09" version="1">MDNLQNSKRQSFLGLSQVNKNISVLSEYSSNTQFHFMKSNNSISSKFLDSKINLGKTNDFRNLNTIPFAKTRYSQLYFDNRNLNSRQKGINNATTGFKKNTKEKSSNKKPAYSQNDVDDVLIKFLDSEKDKTNGGNIYRGKLLEESLNNSVLCSQTDIDAVLKAFLNSKKTYDDSLSNESIKNLPFSEKCNSSDMSNVLSNQNISAKEDIPYDSLLGNFITTQTTDPESSVTDISKELLDSKTRMKKHGSDVIHIFDYSENILSKDILENFLSSNRWDLIKHPYVMNFIDNRLIKKHGSYFDFLLIYLNLLIPLYFATILPPLVFTIFGTIEIIFYVLYLFVSFHKYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C371</accession>
    <name>A0A0N5C371_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C371"/>
    <dbReference type="WBParaSite" id="SPAL_0001242600.1">
        <property type="protein sequence ID" value="SPAL_0001242600.1"/>
        <property type="gene ID" value="SPAL_0001242600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001242600.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44697" checksum="46006CDD887E8963" modified="2015-12-09" version="1">MNPEMNAEVNNDEEGIAIEYIKELEGYLAEAKNKREKLKNVVAKRSHDAKTLRKAARRCDEALKGVENSRKIRTTEILSCISEMERVSLESQELVKEFRKIEKVRKQSCNMEVGDNDEIVNVVEEDSFLTKMLEKIVLVGEETMKMMRVADVTKEESKSLDREIARLQFRMTLLKENEEMLKRLEGDLQDSDNGQPALEMECDEQNGNHINNDDFVNLMEKLDVETKGNVELQIEYKEIKEDLSNLEALSHKVDVLTELSEMSASQMMSQDLNEILKDFPELEDDIVRFKNSMSKLTDKKTSQLSVFNSLQSSHNENIKKLDSLRQERKRLQKTVTELKNEVDCLKEQAGDKAYMLDNSILDKLRLDSTMLEECINVTKQIEDERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3C7</accession>
    <name>A0A0N5C3C7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3C7"/>
    <dbReference type="WBParaSite" id="SPAL_0001248010.1">
        <property type="protein sequence ID" value="SPAL_0001248010.1"/>
        <property type="gene ID" value="SPAL_0001248010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733550" description="Metalloendopeptidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="44"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="281"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001248010.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45630" checksum="2C142B19A6BCF4E1" modified="2015-12-09" version="1">MTWNVVLILIFILENVFINVDQKISEKRAFTNFGETKYNRNRRNVMINQRLKWTFPIYYVVDRSISKIKVMKALYGIEKETCVRFKQVKTKIPGISTLRYYKGPDCSSFLGKNENQPWNNISIFADCNTVGGIQHETLHALGIDHEHSRYDRDYYLRMHFNNMFPAARESFEKASYVNSTTYGLSYDYGSLMHYGTKYYTRNGKDVMVPKDRLYRETIGSLERLSFLDIKTINLHYCRSTCFNRLVCDNWSYQDPNNCRCKCVYGYTGPLCNKFQYATNLCGQTLFVATKMARALRKTGKKNCVYHIKAPENNRVLLKIVSSKVYPNDFEYCHYSNSLEVKFWVDKSATGARFCGNDRNISITSKDNHIMVIFRSTWNKNKFNIVYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Y6</accession>
    <name>A0A0N5C3Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein hunchback</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Y6"/>
    <dbReference type="STRING" id="174720.A0A0N5C3Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001267000.2">
        <property type="protein sequence ID" value="SPAL_0001267000.2"/>
        <property type="gene ID" value="SPAL_0001267000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001301">
        <property type="entry name" value="Blast:Protein hunchback"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002883">
        <property type="entry name" value="Hunchback-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF109">
        <property type="entry name" value="ZINC FINGER PROTEIN 845-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001267000.2"/>
        </source>
    </evidence>
    <sequence length="923" mass="100670" checksum="C08D277C8CE063E7" modified="2015-12-09" version="1">MSHCFERSAPATTTTKENSTTNWHPDSLSIHTISDKRCSAESLFSNLSVDQLNTLTNSGNIFGALTSSLNQSPQSSATSSIYSPDSTTTKQNNMLDVETPNHSLMEGITASAKAASQTANLFKNEINEKEISENDIIDLEKNKQIQSDFMAKINNSFNFSSNQDIVKNDMDAMEIDDQEAANLLLNFSNSNSQQNVSTSSHSNGSYVTAPGLNPPTSTSSSSGTNGTGTFVCSICGFSCNSKFHHNSHMNTHSTHQCQNACGYNTRTLGRLKKHMLSCHSAENRNSSDTTTNETSILNSNIESTGDLAADVQSLVDSVNKVKDELLLDSSQSSALDQIKALTEKSTHIPVGSISSGDLTAALNSLASGNSNDDGLSSSFLDATSSAGNQLILNATNSISGVESPPAEQRRSSGKPKNYKCKQCNHVSTSKDEQWAHARTHIPPEKQLVCPKCDFVTEYKHHLEYHIRNHFGSKPFQCNKCSYSCVNKSMLNSHMKSHTNVYQFRCRDCTYATKYCHSLKLHLRKYNHKRVPDNNGNDDPENFGDSPNGSTNDVSRSLSESYAALADSALSAANVMNNNNNISTSLANSFMLPQIMNTSSPQLLFNQQNLDMNALLRLNSLNNQIQQANSVQGILDANVPCKLCDYIPFTKEDAVKHNIQHFLSNQQSSKPSFNLSSLSNNSLGQNNFSLKVEMPPLPPLKRLQRSGSEGDDEHMTNSPDVDSASGESNVSPLLSGKMSGDETNESVSSSRDGIAGIKRKKGMKLDEISQRLQGKSSPEIEGNSSGGEDNWSTSTPGSKKDLNISSKDDINNSSSQIIHQPIPQMGNISLSNPISAREPANINLIHNGLLAHLTNLQELNKLGSSDDQFKFICTHCKMGFADQALYHIHCGYHGYENPFKCNRCGHSSNDALTFNLHLLQGKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5V3</accession>
    <name>A0A0N5C5V3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5V3"/>
    <dbReference type="STRING" id="174720.A0A0N5C5V3"/>
    <dbReference type="WBParaSite" id="SPAL_0001332900.1">
        <property type="protein sequence ID" value="SPAL_0001332900.1"/>
        <property type="gene ID" value="SPAL_0001332900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895619" evidence="4">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001332900.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21053" checksum="98633835C683E9CA" modified="2015-12-09" version="1">MIFKIYFPILISYLVAFIADAKKPKCGANMVATKCPACTDTCSFTRSLPPTPLKKCYNKKKECKKTSDYACVCKKDYFLNDKNKCVKKDKCYSKPKTTKKPKTIKQPTTTTGQCPPNEIWANCRSACEPNCLDNIKKPKPCPRICKPAGCQCKKDFVRDDSTNTCVKREQCPQTTTPFPTTTRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C693</accession>
    <name>A0A0N5C693_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C693"/>
    <dbReference type="STRING" id="174720.A0A0N5C693"/>
    <dbReference type="WBParaSite" id="SPAL_0001346500.1">
        <property type="protein sequence ID" value="SPAL_0001346500.1"/>
        <property type="gene ID" value="SPAL_0001346500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001346500.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20714" checksum="D1250E080F4EA1FE" modified="2015-12-09" version="1">MPYDEGIFIKKEVVETPIDNVFKNSSFTSSFYELYRNSCGVDFKIICKGKTFNVHKIVLIAHSPVLRTMLVEHKETKECIENTLNIDWVEIPTLQLMINFMYTGTIPDTLSGDEFVDLLQLADRYNITLLHTLCQDRLIKLHLLELNVYELLKVSDTFTAQFLMDACIKMVILIFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6N2</accession>
    <name>A0A0N5C6N2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6N2"/>
    <dbReference type="STRING" id="174720.A0A0N5C6N2"/>
    <dbReference type="WBParaSite" id="SPAL_0001359800.1">
        <property type="protein sequence ID" value="SPAL_0001359800.1"/>
        <property type="gene ID" value="SPAL_0001359800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06608">
        <property type="entry name" value="STKc_myosinIII_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000003">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000006">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="13">
        <location>
            <begin position="855"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="738"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001359800.1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131019" checksum="004941BF8CF9D1F2" modified="2015-12-09" version="1">MGTDPLDDIDLNSLRDPAGIFELIEIVGNGTYGQVFKGRHVKTSQLAAIKIMNINEDEEEEIKMEINMLKKYSHHRNIATYYGAFIKKLPSSNGKHDQLWLVMEYCGSGSITDLIKSTKSCSLREDWISYICKEILRGLHHLHNNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNQAPRLKKGRKWSKKFDSFIESVLVKDYHHRPFTETLLKHAFIKDQPAERQVRNSIKDHIDRHRKMNKKDETEYEYSGSEDEESGPINGNQYREDRPSMIHNPGDETLRKGFQRIQENNRNAFELPGRHHLGGPSTRHNYLNGGLSSSGGGMMKNSSGNNSHGQYINDVKMRQPSIPGSHNGIARQQVGLQQYDQRQRQSNRPLSHHQMRGISPHFPPQQSHPAAPHLADLANYDRKRRSEREALNHHRSERDRSASSRQRNGIIPMDSHINSPMSRVGNVIGNNAIPFRKLSEPVGRPEDLDVLASELNNIGLSGNNGKAIIGGNGQMNGNGSPPPPAPPKRDASIASTMSMHDEQQSIKNDFDIDGENTLRGPNKPLPPTPNEDDFDDNEPGNDGTLMVNKKIIRYQYDDDLSLNYHTNQMPIIGNISMTSHYNNEGRTYDSSESQISVPSNQRHSSYGSNNISRIPTQQTSTINDGDEFGIEESLHQDIMKKQQSLDSQSIEEKSSEGPSSGTSSAIQTPLSQRDREKSFVGYFGGNSNINQPSIVQSAILNTSTARSSGGTINRPGRNNSDAQQITINLNPNSNINAGVSTDNDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYQLINRRRFEQMSVLEGQNILVTISGRKKRIRVYYLSWLKQKILRTEGTEKRNGWVNVGDLQNALHFKIVRYEKIKFLVIGLEDSIEIYAWAPKPYHRFMAFKSFGELGHQPLIVDLTIEESARLKVLYGSREGFHAIDLDSTKISDIYIPPNNRHQMTPHCIVILPNTNGMQLLLCYDNEGVYVNTFGKQTKNVILQWGETPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKKFSFKCFFSFSGNIIYLSKDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7B9</accession>
    <name>A0A0N5C7B9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7B9"/>
    <dbReference type="WBParaSite" id="SPAL_0001383300.1">
        <property type="protein sequence ID" value="SPAL_0001383300.1"/>
        <property type="gene ID" value="SPAL_0001383300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895482" evidence="1">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001383300.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38999" checksum="0FAD86FE46034830" modified="2015-12-09" version="1">MNLFYIKNIFIFFLYFELVKCQVPVKPLTTKYDQDIAKKMLRLSAGAYAIDPSSCINEAYNNNGNFIIFNNRTTTCDKGDNPCSYYSVIDDQNKEIVIVFRGTKTNDQLFREGISTLIDGTDFHDLGLVNFYFNRAHNILWDSVKKIFEDPKYKDYKVYVTGHSLGGALAALCAVRIRLENYRNSSDIYLYTFGEPRVGSSKFALNFDELVPNSWRVIHSKDIVPHLPACGKSSSVNLLQKLFKRISEPCDPNLEDEPYHHGTEIWYPEEMGENDTFMECTGTPKNEDFTCSDQFIYDLNKIKEYAGDHRHYFNHKVPAFGKLGCLPGMESEEEALSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7N7</accession>
    <name>A0A0N5C7N7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C7N7"/>
    <dbReference type="WBParaSite" id="SPAL_0001394800.1">
        <property type="protein sequence ID" value="SPAL_0001394800.1"/>
        <property type="gene ID" value="SPAL_0001394800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="262"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="793"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001394800.1"/>
        </source>
    </evidence>
    <sequence length="1093" mass="126679" checksum="3B5399BD312394FB" modified="2015-12-09" version="1">XDGSDVSLISEKQWERLGRPYMEYTTAWIDNTHSSVGFLGVTELDVSTRKLKGSKEKFYVTPGLTLDENGFDGSREYCHPARSRKGFSLKGRSPIEDGLLYITKNKRTTIPPEIMPIKGVNDIKNNRTTIHLWNFGTKPVNILKNTPICLAIQLKPDEVILAEDEYVAPEAHWEEDLPDKRRTTPLSDEEMLSIVNIPKPLESLILKYKDVFYEYEHDPGRYTGTIKHEINLKEDSKIVKKPLRKYRPEQEEAMMNILNDMLKDGQIEKSKSPWASPVLMVKKKTGDWRKVVDYREVNLITKDETSVLPLIEDILEKVSGKEVYSTIDLASGFFQIPIEEKSKEITAFITPKGLFQYNVTPMGLSGSPSTFQRVMEENFGDMRDSVVAYMDDIIIFGKKENHVNDVEKVFKKLREVGMKAKLKKCSFWKYKVEFLGHYVSKEGIEINPKKIEAIDKLTPPKNRKELRALLGATNYFRRFILNYAKNVAPLTKLLSEKEEYNWTEEQQSTFELLKKKLKEAPILAPPDLNRSFIIHTDASEYAVGAVLLQENKEDKKLRLVACASRTLNSIERRWQIVEKEALALVFAIKSFKYYIEGKVTDVFTDQRALLAIKSAKENQTKLRRYQMTLMAYNLNIFYKEGKANVIADLLSRNPEELLEEPHLTAVALKRDIQEECWKVRPPIELKWFKLSDEEIEKLQEKYKDQINIVDKVGYIKILGREKVYVPERSRNLLIKEYHSNIYLGAHFGNRRIAELIKRFYWWENMKININCEKCQKVKYSPNTTCEWEGTWDPPTRPWVRLNMDIRGKLQTTKRKNEYSLVIVDDFSKYSLAIPIRNIRSRTIMDTLIINVFSIFGYPETIRLDNATYFSSKEFYEFMEYSGITLIKSMPYNHASNGEVERYNRTINETLACYEADENWDLVSPIITHTYNNQIHTITNAVPYEVMFGRKKRPMEKNLCLLNHLNDSELQLDYEKLIASVINNLNKKQSEKEVHKSNFFKVGDAVLKRVMGKVGNESKLKEKYEGPYIVMNVDQNTGNCELSRLLRSGRISHITNRGRRMYEVAHVRQLKLYKTPPGGGEVQVAGGVGAPDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C855</accession>
    <name>A0A0N5C855_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C855"/>
    <dbReference type="WBParaSite" id="SPAL_0001411000.1">
        <property type="protein sequence ID" value="SPAL_0001411000.1"/>
        <property type="gene ID" value="SPAL_0001411000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001411000.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26265" checksum="F8DD9FC5F5CD5D95" modified="2015-12-09" version="1">MSSTEVSTKSKRGWKAFNNIGHKLTYSTTNILFWNNKDKKKNESSSSENNLKYFEVSSQNSSEYKKGSKNAGKKPEHTGRFERSPLVVHGVDTTDSSTDYLIESYKLSMRKQKELISDNTEGVSQRAQSVDRIFNNCSFKGEAFSVENLHPLYITKNKSSTEVNMLHNSFPVTQSIDKSYSDVLNSEEISQEILFWLKNQDTKAYKMEKHERLQAMLSGKCLIKFLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C876</accession>
    <name>A0A0N5C876_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C876"/>
    <dbReference type="STRING" id="174720.A0A0N5C876"/>
    <dbReference type="WBParaSite" id="SPAL_0001413100.1">
        <property type="protein sequence ID" value="SPAL_0001413100.1"/>
        <property type="gene ID" value="SPAL_0001413100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001413100.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43379" checksum="78337FA905F05946" modified="2015-12-09" version="1">MIKSSSCETLSTLVSVEDSTQSSEVIDGNVKIFDIQDDTISLVSSISTLDHDFEEHMHEEVIESFRSEAQKKVRMIFNFFPKLINFEHLPEWLKDNQFILSGYRAPADSLKYVFFSLIQYHNETINIWTHLVGCVMFISACIWMVSRPYNLVPTDVKWIFLPFFVGAILCMICSASFHLFFFKSEKFGTIFAKLDYSGIALLIIGSFIPWIYFTFQCHMKLVIIYITMITVMGMLAIIVSLFNKFAQPKYRPLRAGVFLTMGLSAIFPGIHLFLVESWEVIVEKELLKWNIIMGSLYVIGALQYALRIPERFFMGKFDYLFHSHQFFHIFVVIAAFLHFHGISRVAVHKMSSGSCEEQEIESGMTVWKKWFGTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8X9</accession>
    <name>A0A0N5C8X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8X9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8X9"/>
    <dbReference type="WBParaSite" id="SPAL_0001436200.1">
        <property type="protein sequence ID" value="SPAL_0001436200.1"/>
        <property type="gene ID" value="SPAL_0001436200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001436200.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43003" checksum="5F24E282B7FBEC79" modified="2015-12-09" version="1">MDVFELFSHTPLNIYINKIYITIKFITMEITILMGKEEKIVSGISSDTTCADIIYAMAHSSGQKGKFVLLAKFSEGEYKFLPNEKVLEVMKIKNFKNNLELRQIFPTIERSKSLNKNDKTINKSPLQYTQNSKIGNIMDDQRILNNHLYLQQSYAQKFSDKKLCEENNFRKNFNDHADNRPPPPAYRDVINQKYRSLIGNNSTLEKKQYKQRHSHVNYDLGILDVQTDVNSPITLLTNINRSCNHILKEQQALLQSLEIEFSSEEEKEFYQLLKQKSNLDMIVSQVKECNYEEKLINCKKESLGLQNQIKSVETNIQQMNDDIDHYNKLISRLEHEISVILEQDQNDYYNKPSSIPSVNRYGSNKASVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C948</accession>
    <name>A0A0N5C948_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C948"/>
    <dbReference type="STRING" id="174720.A0A0N5C948"/>
    <dbReference type="WBParaSite" id="SPAL_0001443100.1">
        <property type="protein sequence ID" value="SPAL_0001443100.1"/>
        <property type="gene ID" value="SPAL_0001443100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF6">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001443100.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16871" checksum="54B4391B0077AEF7" modified="2015-12-09" version="1">MHYYFPPKNFTDSCWLPDKSIGQIPCRTACFVLIEDTEDEFSPKAILRGCVDRLLLFGMDDDVKDAIITYHKSCRSTDRHLLQLISLSKDSQYVLMCTCEGKLCNDEDMRTTLETSSASKVIFLSPVRYIIFHVSIIAIILLKFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBM7</accession>
    <name>A0A0N5CBM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBM7"/>
    <dbReference type="WBParaSite" id="SPAL_0001529400.1">
        <property type="protein sequence ID" value="SPAL_0001529400.1"/>
        <property type="gene ID" value="SPAL_0001529400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529400.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62213" checksum="38B6025A739EDB32" modified="2015-12-09" version="1">MSENVSSYNDFLKNAIANSNSNVNNFLLFVKVAKDMNKGFEFSDSYSRLLRGKIKEITGELLYKLDKNREAYIYVNEIRVYVKYDFQLNEFHKELEVLSYRVADDHPFTPSKKLHVIKTKIDIGGDSSYEANEKEGDLERVYNDEKNLDFSLNVLVLLKGAMNETKVPNEFVFNLIVGDYLGNTMNCVFFKSDSSNSIYDSVEIGKYYNLSLSNAKTFLLKSSSRNFTTFDKGLALTFNSTKFLPASRKFQFPGIDVPLKDLECINDYEIDQQASVIGVVVKIDDISTYIYDGANVSTSRRIIYLTNGTTTVPIFLHGELAYCEFEVGMLVGVKYSIVRKHSAGGRILSCNRASCIVKDNLEEYKKVLTKVCDMDLDTIELPDVYTAPTVEEALSNGKFLIHIKGLPSFKIKPRKFLTMGRITFFGKFTISEKAKEYGPFAKVTIADSLVHISSITLFANRLSNLIQNLTGNFSTIIDNGTDGDVVLKNLLHIPMLFKIKISNYLGDGNNGEIIIRGNKIIEYVGVCPDGIYEQWTERMKRELSCFSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD30</accession>
    <name>A0A0N5CD30_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase cst-1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Serine/threonine-protein kinase which extends lifespan and delays tissue aging, probably by activating daf-16.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD30"/>
    <dbReference type="STRING" id="174720.A0A0N5CD30"/>
    <dbReference type="WBParaSite" id="SPAL_0001577600.1">
        <property type="protein sequence ID" value="SPAL_0001577600.1"/>
        <property type="gene ID" value="SPAL_0001577600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21884">
        <property type="entry name" value="SARAH_MST_Hpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06612">
        <property type="entry name" value="STKc_MST1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000605">
        <property type="entry name" value="serine/threonine-protein kinase 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024205">
        <property type="entry name" value="Mst1_2_SARAH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11629">
        <property type="entry name" value="Mst1_SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="14">
        <location>
            <begin position="462"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001577600.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58189" checksum="C9BA0A46E14F9D45" modified="2015-12-09" version="1">MDENMIKQDIKLDQDTLNKDPDEVFTIVNKLGEGSYGSVHKAVHKSTGHTFAIKTVKVGNDLQEIIKEISIMKQCDSDFVVKYFGSYFKNSDLWIVMEYCGAGSISDIMRIRRKTLNENEIAVVLKDALHGLKYLHDLKKIHRDIKAGNILLNENGRAKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIRESGYDSQADCWSIGVTAIEMAEGKPPHAEMHPMRAIFLIPTKPAPTLKNPKIWSKEFWKFTTRCLVKNPEERANASDLLEDPFITSAKDNNILLEMIKDSQNIAKSLPNVNQILPTTKTSYSDSTIKNDSTNSSTMIYKKTLKVNDYLDDKKNEYLDGTLVQEQQVQNKNNNAPISCVQYNDVYKTAMKAENNFKFIGNDGFVGTPRPIQHIETGNSENNYLYKTPSLVNNFHMFNLDESGAVGGIGSISTTSSEINIFNNFENDISKGYGFLKKMTTEELLQKKGNLEFEMDNELRDLQKRYQIKRQPILDAIELKKKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDH8</accession>
    <name>A0A0N5CDH8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDH8"/>
    <dbReference type="WBParaSite" id="SPAL_0001592200.1">
        <property type="protein sequence ID" value="SPAL_0001592200.1"/>
        <property type="gene ID" value="SPAL_0001592200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012023135" evidence="1">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001592200.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28656" checksum="9274B419D4407EE5" modified="2015-12-09" version="1">MLYYIILFFPLTSYAFFFQNSPCSCVQQNCPISPPCPESTVQNSVITPPSGNLYQLQYNTSPCFETNTDNNYGSNLPVYQEPLLITSSYSPINTYEYKEIPQSQPIYVSPGQMNGNDIDSYQSQKGYNIQDMTATVDNNYDNILQQEQRDSLSKGKVFTEKTSMDTVNKKKKAIHKQKTQFKSLCNNSKLARIMAESIVSDISISKLLISDAIAIAYKNTKANVICASGDFSYSILVQKEYCEATKGNVTCFAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEC9</accession>
    <name>A0A0N5CEC9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEC9"/>
    <dbReference type="STRING" id="174720.A0A0N5CEC9"/>
    <dbReference type="WBParaSite" id="SPAL_0001621900.1">
        <property type="protein sequence ID" value="SPAL_0001621900.1"/>
        <property type="gene ID" value="SPAL_0001621900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001621900.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42399" checksum="40FCC6753D453970" modified="2015-12-09" version="1">MDRKRKRRSGDIFKDDLRNIHGNVNKFNYICSIENFSRRLEKTGEPIESPICVVGSERTSEWYLSIYPNGFNEDYKEYVSVFLNLLKPDKAKAKYKLSILNDRKEERNIRNSKKVGEFDVNAENNGWGYSNFVKKNFLLNELNGLLVDDKLTILCQVEILNLGSENYDSPETSINVTIHQSKLSLDYSKMFESQLFTDCIVKVEDTEIKVHKAVLANRSPVFHDVFNSMSKNLQTNVVEIKNFHVDVVKKMLRYIYTDDISDIKNMASEILAIATEYRLDGLREVAVRHLCRNLNIGNICERLLLAETFSSDELRENCQKFIIGNPECLKTTNNLEEFIRNHPSLFKDFLFKVVQLLSTSNNNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEX2</accession>
    <name>A0A0N5CEX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEX2"/>
    <dbReference type="WBParaSite" id="SPAL_0001640900.1">
        <property type="protein sequence ID" value="SPAL_0001640900.1"/>
        <property type="gene ID" value="SPAL_0001640900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001640900.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="72428" checksum="E32D95E84BD90F4E" modified="2015-12-09" version="1">MSQYNCKTPSEVDFEGDQELSRLYKEALDSLGNEVNNENCNNQAKFNHLTNIRKRKIGSRKSRNKKDDSLEKTSCGGKGTYNHLNKSKTFLLGGGTKKPRRDSSKTTKTSEYLGKPTVPKMPSDLASSVNHYFNTTRRVEQISSSLPRNFVDGTGTFNPENDFETIWDITVNRVEDMDKELKKLRMELTILIDQYHNQLRVEEKYKDNVISEHEIFTRKLSSMNFTPDSLKVSPQLNEAIMMYECNERVVNNMRTKYLEKFIEHKAFVEIYKEFRAFFKNLSHYKKDYDNYLTKLQAYYNTMESTKKCFEGNCGLNDKIEMKRIRLSTSSSVFDEVNVNSSTSYGSCTYSTTPSLLCGKKSSIFTESNGDFLKNLYTSDNGDQSHGNILNDSYKPIDDIHFSMNARLPCDSNSNIINSNNCAGKSTNADNASRMNTNGKSKDEVTNDKLGTFVNVYNNVDSDVNDVTSFEECSTKQISVNDSNDGDVVITKVVDISESLSSTSSPLPPPPSTDVYINEEYQLQDSVSGESDTVSRKDMLSQIHSSIDEIDDLMCYFDVYGECMDNKCQNLHQIHKKLLVECINYCASSPTLLNAIVNEKNKSDDTLAYYVFSIFRKNKYNYEETIKKLDELVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFT9</accession>
    <name>A0A0N5CFT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFT9"/>
    <dbReference type="WBParaSite" id="SPAL_0001672200.1">
        <property type="protein sequence ID" value="SPAL_0001672200.1"/>
        <property type="gene ID" value="SPAL_0001672200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001672200.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50116" checksum="4C56C68CE21B6174" modified="2015-12-09" version="1">MSHQESGVISHIFTFYVKSFVKSYQFWIKCCKDNDSNILKKVHSVIEKGEHIIDETVTAIEDDIKGVVGSVLEKESRTQAVIQKNFGILVSTYKFNIIVLLLLSLASYFFYKKVQANIQRNSIQQLQSCHLVSSKSDSTQVGDKIKKDSNKKSEELSAKIKEIVHRLARADSATAYPTPKLTPEVRPFEPRLLKGESKNNNIDTSSICSGPETSKTESLAPDVLLSPIKPTVVPVQEAIIKKRVSLKEDKKSSKKNSKEMHNASNAFFDELNKASQETQGENSKKGKNSNVNNNQGHHQDLFPTELEEPTLGDALKEQKTMKNSSQKEEPFDIFGEHNLNQNKPQGLLTNNNNGLLEEKKISPKEDVYVFPAQNGNENSTKQPKTQGGKENDLLLDKTQSTGANNQLESVNSLNKDDPSSTTSSVSSTIDLKRGPKNSIFEALIDDMAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFY8</accession>
    <name>A0A0N5CFY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFY8"/>
    <dbReference type="WBParaSite" id="SPAL_0001676800.1">
        <property type="protein sequence ID" value="SPAL_0001676800.1"/>
        <property type="gene ID" value="SPAL_0001676800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001676800.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33279" checksum="0B9F9DF968FDF585" modified="2015-12-09" version="1">MTSYQDKCKYTQFRRELENVFSGIKILLLDKLENPNDYWVSVDLKLTKKDMDDDYNFSQANENFNKMILEKEKRRKKYEKVNKDEYEKIRKVEKRKSRKKKEKIVTLDDSDSSREIIDKTTCSNDSSKSLVSTKCKKSKKKRSCKKKNMKSSKTKNIKEKSISKKNKKRDLHSIKKSRYFPNLDDDVFYDESMSKSIKEGKSPNNNGPTNQDTSEVTLDTIISTNHVNQRNVSPQYELSLSKIDPKLLSSKNRSLHFHRNKTLRFIREACCNSRIVLFKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG65</accession>
    <name>A0A0N5CG65_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7585 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG65"/>
    <dbReference type="WBParaSite" id="SPAL_0001684400.1">
        <property type="protein sequence ID" value="SPAL_0001684400.1"/>
        <property type="gene ID" value="SPAL_0001684400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896056" description="DUF7585 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="2">
        <location>
            <begin position="53"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001684400.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25737" checksum="CFBA855A728A9A29" modified="2015-12-09" version="1">MFVKLYWLGAALALMPLPIQPQGPHDENLPLDVSENIDGPKLSVDLKAKKFSEIVLKSSNSTRFSCGEVTIKPGDVMSPMIGWTYNVKWNNGREDKTRINSNNMDYPLPETHSKCHNKTENLLIVSRDKENDTAVIINPRDVKNSYANQEFYYFITPKQNDGIQIIEHCGRYRGYKNSPHFNLPDHSDNSTINEVKKININESNYEKEEKIKVDLKLGDDIQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG77</accession>
    <name>A0A0N5CG77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG77"/>
    <dbReference type="STRING" id="174720.A0A0N5CG77"/>
    <dbReference type="WBParaSite" id="SPAL_0001685600.1">
        <property type="protein sequence ID" value="SPAL_0001685600.1"/>
        <property type="gene ID" value="SPAL_0001685600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001685600.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42800" checksum="23965AD35CCAF1E3" modified="2015-12-09" version="1">MDQKRKREINDISTDDSHNIIRKIYRFSFVYSIQKFSLRTEKTGESLTSPTFVTGWKKRSEWCLNETKKLRAFLRFSILNEKEDEENVVDDRKVVYFDKNNGFGIPKFIKKDFLLDKSNGLLVNDKLTILFTGVIAFYKSDNQNNPETPKQVTIPQSKLSLDYGDMFDSPLFTDCIIKIGDTEIKVHKAVLAARSPVFYDTFNTTLEKSQTNIIEIEDFRVEVVREMLKYIYTDEVSNIQNMASEVLVIADKYKLDRLKAISEYSLGNSLTTENVLECLALSDNYSTESLKDCCLEFILENAGWLARTKKWKKFVLAHPLLLERLNCDDSLFFSLPIFLNTSLLTKEISVNQVNTWFFLFLYKSQSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG85</accession>
    <name>A0A0N5CG85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 6 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG85"/>
    <dbReference type="STRING" id="174720.A0A0N5CG85"/>
    <dbReference type="WBParaSite" id="SPAL_0001686400.1">
        <property type="protein sequence ID" value="SPAL_0001686400.1"/>
        <property type="gene ID" value="SPAL_0001686400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001686400.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9885" checksum="D81228DD5F80D8A2" modified="2015-12-09" version="1">MSSEVGLKNSRKKCYTARDLFLECFEKNNESVSKCRLEYKNFEQNCPTSWVEHFIRKYKFDKYKEELKSGGFLVEDEKNAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG93</accession>
    <name>A0A0N5CG93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG93"/>
    <dbReference type="WBParaSite" id="SPAL_0001687200.1">
        <property type="protein sequence ID" value="SPAL_0001687200.1"/>
        <property type="gene ID" value="SPAL_0001687200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001687200.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20885" checksum="7ACB84FBFDB0F2FB" modified="2015-12-09" version="1">MTSYLREYILWYHNQKRLLLSTNGTCLPKAKNINELTYDCYLENTAINASIPCKLELYGDEDIGENLYMGDNAVDYIYNINDALERWWTQYLNLQSIYFNHTHDILNFAQMAWENTTKIGCAVKTCDTATLFICHYNPRGNIVGEPIYKTESSCYNDTDCKIFNEGFCNNITGLCQKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGR1</accession>
    <name>A0A0N5CGR1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGR1"/>
    <dbReference type="STRING" id="174720.A0A0N5CGR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001703600.1">
        <property type="protein sequence ID" value="SPAL_0001703600.1"/>
        <property type="gene ID" value="SPAL_0001703600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001703600.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13480" checksum="A597AF61F6363D06" modified="2015-12-09" version="1">MADLKQEKPVEDDAVRRIRITLTSQNVRALESVCDQLILSAKNEHLPVKGPIRMPTKTLRITTRKTPCGEGSKTWDRYQMRIHKRLINLQSGTDKLKKISSISIEPGVDVEVTVADSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH46</accession>
    <name>A0A0N5CH46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH46"/>
    <dbReference type="WBParaSite" id="SPAL_0001716800.1">
        <property type="protein sequence ID" value="SPAL_0001716800.1"/>
        <property type="gene ID" value="SPAL_0001716800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001716800.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9753" checksum="303AB4269AFC4F2C" modified="2015-12-09" version="1">MCTILKRKIKDVTLLEVAKTTTNVILVARSIFTGIMLLNFTMKKSIFSCIRLLLRGNTVSQDTTKDNNLVKEVDVYFKQLKDAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHF5</accession>
    <name>A0A0N5CHF5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHF5"/>
    <dbReference type="STRING" id="174720.A0A0N5CHF5"/>
    <dbReference type="WBParaSite" id="SPAL_0001727200.1">
        <property type="protein sequence ID" value="SPAL_0001727200.1"/>
        <property type="gene ID" value="SPAL_0001727200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001727200.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17060" checksum="6497D12DA6EBCDFC" modified="2015-12-09" version="1">MNPMHAWELEPVFGYPIRHPELYNKTKETEEMKNDRRKRQTTEATTTTTVKPDVNVTFEQLFSNISMTTVGNFSKYGKLDEPWLKFNDTNKLGLVISGNLSEVKYVNATTKKCMKLAALFKKYEDILPKGSHLDLILERVAVEGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHR4</accession>
    <name>A0A0N5CHR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BBP1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHR4"/>
    <dbReference type="WBParaSite" id="SPAL_0001737800.1">
        <property type="protein sequence ID" value="SPAL_0001737800.1"/>
        <property type="gene ID" value="SPAL_0001737800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001737800.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37332" checksum="C556B2AA90BBE0FC" modified="2015-12-09" version="1">MSSRNSIVISSFPEDEEQNSFSWLIGKIFCRPYWKESDGYTKTNTFITNSDSGYFDWTDSGVSRSSSFHLPTSRVWSDYDLCQGDDEDQENNNFMKQNSFEYIKPSTVVTKSTSILSSIFDYISNPFSIESPKRSNSLYQFNNTSKGFSNYSIDDNNNNNSVTGSLTKTFPTDCTSTLDKMSSIRKASETQISPVAEQHYRRLLSQISLSNCSLVRENEAMKERLQELESLLDDHMKHLKSIYFTLYKNGYSKLQFPDGDEVNLAQFEGLLLNFKKSPQPEEGYTEENNLDKHLVVEASSTGESSYSSRKLTNSFTELPPVKESYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHV2</accession>
    <name>A0A0N5CHV2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHV2"/>
    <dbReference type="STRING" id="174720.A0A0N5CHV2"/>
    <dbReference type="WBParaSite" id="SPAL_0001741400.1">
        <property type="protein sequence ID" value="SPAL_0001741400.1"/>
        <property type="gene ID" value="SPAL_0001741400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001741400.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19717" checksum="16FD7B59A7B0927E" modified="2015-12-09" version="1">MADEQKKKRTFRKFSYRGVDLDQLLDMNREQFAALLPARQRRKLARGLSPKHERFIQRILKAKKECPALEKPACIKTHLRDMVILPEMVGGVVGIHSGKTFNQVEIRAEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLNKLLYKRKIFFGLVRKVKLHNKSIYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CID8</accession>
    <name>A0A0N5CID8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CID8"/>
    <dbReference type="STRING" id="174720.A0A0N5CID8"/>
    <dbReference type="WBParaSite" id="SPAL_0001759100.1">
        <property type="protein sequence ID" value="SPAL_0001759100.1"/>
        <property type="gene ID" value="SPAL_0001759100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF12">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001759100.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63167" checksum="BC994881BDA629F9" modified="2015-12-09" version="1">MPLKIKEEEVYCLDFTRHDERFDPLEKTIPELIHSKDAWDEKDAIICDSEKTSLTFSKISQLMDQLAAGLLVSGIPQGSKILICSYNHYDAIICALACTRADIIFCLNSPKVSSPEYLHDLIVRGGFKGIILFKPGKDSDEMGSMLLDMYPEMKQCTRGKLKINNAPNLTHVILADEDHRHAGTFTLSDIYGKGTKDKIDKLPQYRNWNCHKLAAIQYTLGHSDKPKLVGLSHYQLINGAYTASFAIGINKTTKLCVALPMYRIPVFCLMVFTPFIHSSVTIISEPSPVPRLIFQSIAKNFVNCLLTNGIALKLLLRISIAQKVTMPSIKTCILIGEKVHKNILTDMVKQMPNAKQIACGYCLTETGSVPLLTDNTSNLITSVGKCLPGYEIDVRPIRGLESNKEIVGELFIRPFNATKFFGYAPTFDTCGDWVSSGDIVSVKTDCNIELISNKEDLIYDKDNKLVQHWKIEKCLSKFHEIKGIQVISICPGAPVVAVVIPRNVITEKNIDYFKADMITMLKNENIRVPEKFALVFDFPRTHARIKKRDIRDIIMNKQAIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIE2</accession>
    <name>A0A0N5CIE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4005 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIE2"/>
    <dbReference type="WBParaSite" id="SPAL_0001759500.1">
        <property type="protein sequence ID" value="SPAL_0001759500.1"/>
        <property type="gene ID" value="SPAL_0001759500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001759500.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21729" checksum="F591469FC6602BB3" modified="2015-12-09" version="1">MSFRLIIGDHGQADFHRLFFNLIMVGVAVKCVAVCKLNLMEQSKNNELVKFSLPSGNDTLPGVVRRRSSQKKSHSPSRLTIKDNGPSMEARSPGQLRRVDTLRQQLNVGRYAPKSRPVSAIRLPERQTGVRMSQKDVKGLERKPSITESIKNSHGLRKYSNPTIGQPNLQKPHRGVIQPFKRNKSCRGWSCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIY7</accession>
    <name>A0A0N5CIY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIY7"/>
    <dbReference type="WBParaSite" id="SPAL_0001779300.1">
        <property type="protein sequence ID" value="SPAL_0001779300.1"/>
        <property type="gene ID" value="SPAL_0001779300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001779300.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="13190" checksum="A92EB692F8DA1863" modified="2015-12-09" version="1">MESKPLFNIDHNIILKSDWDQWEETIKNKMKEELGECSKIFREKHLKTKEKITEIEQNKNDIIKGCSIEKKDPTEFLKVPAYAYNKAYILYEWYKLENKFREHYLKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2E0</accession>
    <name>A0A0N5B2E0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AIP3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2E0"/>
    <dbReference type="STRING" id="174720.A0A0N5B2E0"/>
    <dbReference type="WBParaSite" id="SPAL_0000024700.1">
        <property type="protein sequence ID" value="SPAL_0000024700.1"/>
        <property type="gene ID" value="SPAL_0000024700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="3">
        <location>
            <begin position="214"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000024700.1"/>
        </source>
    </evidence>
    <sequence length="966" mass="109140" checksum="D5150F0F0BE62B33" modified="2015-12-09" version="1">MPTLFNFRVPIFSRGRKTPDPLSCERIYDTKLSSDNLSKGISRTVRFDEGVSKDPNQLPPSVTIHSNINPQITPHQPTNVAPSNYINPTLQNVNQSKVNPNQQPPWNYVNGYETDKNTSSKNNYNNIPDSHNQHYSNMGSLPRNYSSSSRNSQNMSTPHHRANKLLQQLRSDDDCDYSENDEKLDAIQQANKISHQNYGKSHIGSGIHSSGVIFVQYNDETKRALLPPKLNSIEQLKNIFLKAFPYLSSQYLNLSYVKIYIQDSTDKSQVFYELDDLRDVKDRCILKIREQISGYQSPPPIRFTDKVPGTFDYMSEGEGDDYNTVYGRNSNYARLGIQSNYRPASAIPGTDGRMYSAQVTRRDSGVGKNTGSKFDPYYDPYFSDTSSTGVPQSPCMVPRSANATPTIDREARFRMETMEKQLQGLSSLVHSALVTKNIDNFGQKDISDLRKQILEFNNSSTDNCDILSTTGSIDMRNLDSCNTSICSSVTGNDNLIGDIRKLRKQIISYTTDIKQLKKQAQDLKKCNNDGLRDMKDRINVLLNNYVSNIKNNDIKIIEIEKNANDDPETENLRKDHISRMAYLHTNLSTFERNVENLRKTVVDGNKKLKMIEVENLTNTLTTLGRTAAQLKTDFPTLYGKIENKIKNDMECVIKNETFIKEEQNHIDNCLKRCKTLANMMVTMKKLAMVQDPAISNYTNKVQQNYNNSALFNPSKPPVPKLNVPSNTNNISDNKNYEREQSVESDKGKDDDDITIMAEPLPQNSHQQGVVNKGIPPPVPPSPKNYYAPPLGGEEKPPVSKKFSSNTHVLDSILDELSSNEMEPEEKSNIKLHLNGKEAPKYSLKNEKAKSPYENISSSYNNLNEQQPPSYSSLSNKFPNLSNNLTVTPSYTTHRNDKYLPTNNSSDSPSSSSYSPSISNSSVTCNSSDSSSLFSHNYNPSEYSLREKQKQLDCQFEQLQKLVPMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2E5</accession>
    <name>A0A0N5B2E5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="2">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2E5"/>
    <dbReference type="STRING" id="174720.A0A0N5B2E5"/>
    <dbReference type="WBParaSite" id="SPAL_0000025200.1">
        <property type="protein sequence ID" value="SPAL_0000025200.1"/>
        <property type="gene ID" value="SPAL_0000025200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000025200.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54346" checksum="9DF898D7FF4F3A16" modified="2015-12-09" version="1">MPIVKRSVSPVNVSSHRLAPSIKKDELECVANGTLANLIRQLSSLSKQAEQIFGDLTNEAIKIDHKATSLTQRVEKLKIKIESYEGNDDQDALQDIQYRKPFKSSNLIDQQTFDRQTLPIALQDLYNKCEPPPNLNELNEFRDDPKPALKYYTDPGYFFDLWKKQILKECEEMPKRKTLKNMSQSPEKKIKKRPTEGMDGVTRYDSEFAMPIYGTYKPPKILPSKLSQQPAFQPMSSTTSIRGRQPNFVQFPEEYQAPRALQSTIKDNDHFPAPPPGMSLQYNSIFTPSSQFLDTQSSTLPPPLFTSDSPNSLEQTLQNFKITDPIEEDEEEELPPPPNVMITSTLVSQVPSLPKLDLVPTEGSSAPPPPPPPPPPPQVGQIKLQTAAAPAVSFTSEKKNNENSENENGKENGGGPPTTRGNLLAEIQSGIKLKKVQRKEEKEAEKAAVDDTNDVAAILRRRMEHVLGHDDSSESNEDNDDEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2I9</accession>
    <name>A0A0N5B2I9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polo kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2I9"/>
    <dbReference type="STRING" id="174720.A0A0N5B2I9"/>
    <dbReference type="WBParaSite" id="SPAL_0000029600.1">
        <property type="protein sequence ID" value="SPAL_0000029600.1"/>
        <property type="gene ID" value="SPAL_0000029600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF43">
        <property type="entry name" value="INACTIVE SERINE_THREONINE-PROTEIN KINASE PLK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="8">
        <location>
            <begin position="295"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="8">
        <location>
            <begin position="393"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000029600.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="57504" checksum="4411234012349B72" modified="2015-12-09" version="1">MYDLTSLFQINNEIEILSSLRHNNIMNLICHFDDFKNIYLILEYCHNLTLRQFFRVRRIVLEHEARYLVKQLSDACQYLHSNNIIHRNLRMGTLYLTSDLSLKVGKFEVSKRICPNGNMDVESRRGVYKYMEPEFLTKEYLCKIDIWAIGCILYKLIYRKDPFRKQGQKNSTVKMSTYRLDLPRNGSEALKELITSLLHLSPNRRPDAKEILDFNFFTDAINVSAVPKSLCGRLSLFPCSMVAENVKDGSLSDTDRYAKLPRMWSRVKNVLDGSRSMNTIITSEYQKPALKSPCFVTRWTDYSNNNGLFYQLSDNSVGVFFNDKTNLIMDNFGERLRYRNTDGSEILFSRIGCPSDFQEKLHLLLQASKYMKENLVEACSTQDKETKFRRSPVLKKWLRTNKIIIFWLSDESLQFNFMDIHRKIILSSEEESITVIDKGMYTRSFTLEELEKVGGEKSLKPLLTMLESTGGMAYSNGQKLEVLSGNIGPDFFCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3D6</accession>
    <name>A0A0N5B3D6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3D6"/>
    <dbReference type="WBParaSite" id="SPAL_0000058700.1">
        <property type="protein sequence ID" value="SPAL_0000058700.1"/>
        <property type="gene ID" value="SPAL_0000058700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056709">
        <property type="entry name" value="DUF7807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF2">
        <property type="entry name" value="PROTEIN CBG16728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25093">
        <property type="entry name" value="DUF7807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000058700.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23553" checksum="E323AE8767B5172F" modified="2015-12-09" version="1">MSEDVENDFIDFKKFKHQRKYRCLCNCMHIKNGAFIMSLWAALMVFLNITVKIIGFTETDWNWMLLFLITDGISILSLIYGIKTEKPALIQPFVVLSLLTIPLLILLVMFFTTAIYDQESFAGHYIETEFTRKYLKNFQKYTSTDIKLQIKLSAIGYVIFLSTTALLHLWFSWIFFKCASYYRDCEEFLSNIKNKTTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3U0</accession>
    <name>A0A0N5B3U0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3U0"/>
    <dbReference type="STRING" id="174720.A0A0N5B3U0"/>
    <dbReference type="WBParaSite" id="SPAL_0000074200.1">
        <property type="protein sequence ID" value="SPAL_0000074200.1"/>
        <property type="gene ID" value="SPAL_0000074200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000076">
        <property type="entry name" value="Glutamate-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000074">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022272598" evidence="11">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="71"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="283"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000074200.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59404" checksum="503B1E220AC23956" modified="2015-12-09" version="1">MLFKKSLFIGLLLLIPVTLSMRASKLKYKKINQAVKFENDIEEEEEEYMDDRNVVYHGQSLRFLNFLRKINYDHREFPRNSGSSEPVTVYVSVVVNNVRSVSEVTMDYSLELIYREMWTDSRLAFDKKEFQNKKTLELHESYVENIWHADTFFPNSIQSKNPKERSISHRSLLRLREDGFVLYSRRISVVAECLMDLTLFPFDSQLCKLDIESYGHTIDLLQYNWSKHNERIALKLGSIRLPDFQIIEAYVTKKNETYATGTYSRLYICFIFKRSIGYCFLQLIIPSTAIVITSWVSLWMDNQTSFHDMISIILAITFLLFSYNEVMPRVSYIKAMDVYLGVCFCIVFLSLIKLSILRFMRERTFVPSEKFNFLPNFCKMMMATTNAASIIEKSQTRMNNVEEGTINDKEDLIDASKITLNPFLGREDTDNIQFPKISNSKHSKFYHITFKKSTIRIFHCLTQLGFLIGFTLFLIFYFAIYPYIHPLKIDAACQKEDAEFYAKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B465</accession>
    <name>A0A0N5B465_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B465"/>
    <dbReference type="STRING" id="174720.A0A0N5B465"/>
    <dbReference type="WBParaSite" id="SPAL_0000086700.1">
        <property type="protein sequence ID" value="SPAL_0000086700.1"/>
        <property type="gene ID" value="SPAL_0000086700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="11">
        <location>
            <begin position="174"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="357"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="304"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="388"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000086700.1"/>
        </source>
    </evidence>
    <sequence length="707" mass="81928" checksum="D2B51D86F8742CC5" modified="2015-12-09" version="1">MNTGESQSFIIEENNTNNLVARVPTAQDRKTPTYPTTEILPWALPGESLQKKEKNICCITYYIKSRGVVYVTNYRVHFESDEAPEDSFFFLLGNVARIEKFGFSSNTTRSNVYGIEICLKDQRKIKFAYPKQSVVRHIRRDFYQILHKMAFPISYNLPFFATIYRSIVSYELDCWNLYNPEAEYSRFGVPNNDWALCHINQNYTFCSSYPALLYVPKISIDNNYEFLNKIANSRSSRRIPVLSWMNSKTSAAIVRSSQPLVGFKLSKKYTDDEKYLQQIASTNHNGLWKLNIIDARPHANAQANRAKGGGFENYESCSLEFMDIQNIHAVRELIKKCRDVCAEYPEHEKLKDIVESTKWLSYIRSILRASEAVVNLVHDEKKTVLVHCSDGWDRTAQITSIAMLMMDPYYRTINGFAILIEKEWCSFGHKFSHRCGHGVDKPNDSERSPIFLQFLECVWQIYNNYSSYFEFNDRYLLFLADELYSCRFGTFLFNNECERIKEHHCPNTTVSIWTHIYNNYKDFVNEKYNHNLSTTGDSNSTLKILDYNKPLDVWRAYYSGPALESLEKLKEKRERLERESEEKNINNFSRKKSSFDASSDDNSSYSLVEVEDADDALCREFKRQNISFNISPSLNSNDYKNHHSNNHSTIVLYEGHSTFHKQSSPAIIPTRPAPPRPTPPRPSPPKLSTSNINAVKFSKITEASSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B491</accession>
    <name>A0A0N5B491_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B491"/>
    <dbReference type="STRING" id="174720.A0A0N5B491"/>
    <dbReference type="WBParaSite" id="SPAL_0000089300.1">
        <property type="protein sequence ID" value="SPAL_0000089300.1"/>
        <property type="gene ID" value="SPAL_0000089300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="3">
        <location>
            <begin position="825"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000089300.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="111022" checksum="DC61588E3FCD9F8F" modified="2015-12-09" version="1">MGLTKQQITANYSYRHPGNYYAHVFLSSYTRNNQPLKLLYNAQEFIKQKDLTRCYDSFLNFLTTDIMNIPTDIYPETAEIVIDVLKQTDAESDEIIDISFEILQYMVQCTASNMKLWSKLLVLFHIPLENRNFCCRSYSTELMKLVESCITQGTYSDDEEVIIYKLLQGNLNACDRERRSSAFNCLVKLIISKPNEQIPTEFLKKFLRDMAAHHDYIMREISVKFLEQLADKNLVGIEFYSIIKDLCKDSNVETRRIALRVIQKMAQKYGKLMVKSHNNFEISLNDEAFAILCGAFNDADTLVRAEAAVVIGKFENVSPNFLLQTLDKKLIPSMIKQDDNNKGRDSPYFYQWSSGMSLAEDIPCESKSEESKSYIPPQACGAFVTALEDEYMSVRKGAVTSLGILAKGQPNIACFALDHLADMFNDDIDQVRIDAITALTPLLVYGKISRDQLITICTVLDDALPDSRLTLHELLCKANLENADCLLLLYQRLQQSLARFPEDKLSIYKCFSFIGRSHYQFVPGILYKILDIDPVFKLTERTFQESSHVASLIMVLNATVECEVIASLLPDYMIRQYKSLHSSMPDLVPPIRAFEDESGFHYSGNYVTKLSKSVYEYFSTMFEELYNLLNLPNTPSSINAIDEHLEQFYKSMDFDESVSANMRFFNKFCKAIRSLKFMMTMNEEEKKTLLLVNNILHETKELEISFTSKNPRLHHYLIYIHFLTKIVEWTRCLNLPSDKIFFNIMLGLEKLKASNIYFNNGNGEMILELSDKFKKCCNIINENGIIDDGLVKNLIYDIVKNFKLQVSKDDISFNVDMRLRMANVEVPNKQNEKMRTAVLKMPVTIPYVVVLKHFSDYDLNNFCVKIIYPDGTVGYNSPRSYEFHRVDNDTVRLRTKLKILFQYSWNGIAYITVQNGLMVSRNMISNELRTNFLSEPGYFQPIRQFYCRDNFSETILGFTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B493</accession>
    <name>A0A0N5B493_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B493"/>
    <dbReference type="STRING" id="174720.A0A0N5B493"/>
    <dbReference type="WBParaSite" id="SPAL_0000089500.1">
        <property type="protein sequence ID" value="SPAL_0000089500.1"/>
        <property type="gene ID" value="SPAL_0000089500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="314"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000089500.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="78385" checksum="89E411BFB46B39C6" modified="2015-12-09" version="1">MKKQLSLLWSKQFLRFLFYNLIEKREANCGKGNSINVLRKADNTNISGLSLGDVRNSIQGLLKNFVKNCNTSPIPSPGINTLICDLYYNILETFQNIQLDILAAITSDDLILPALWSHINRDHRSLNFYFKILQQDKNLESPHCSVLILFSKATISILNLLDEKEMYEIQKPFSLNELCEIARFSNHFCFKATWNRVIKIEQPKDHPVYEAMYKLLNILYNRDWRRSFTSHHKKFWIAPDTKGTCIINMYENDDKEAKFIMTYLPHLIPLMDRVEYFRKIVGKEKDTCSSPAKSITIERTHIIEDGYRQLNGLNPKDLKNTIRVKFVNAQGLDEAGIDRDGVFKEFLELTLRQVFDPQLNLFHTTESNYIMPSPTSYFHEDHLQLFLFVGKMLAKSVYEGIVTDLKIAPVLLAIMTGKKLSAFDELSKLDPNLYKSLTYIKYYNDSDDIGDLDLTFSIDEQELGVIKTIDLIPGGRHIAVTNENKIRYIHTMAQYRVYVQTKEQNAAFVKGFTSVLDQTWLNFFSPHEIQFLISGNNDDINIADLKMHVHYYGGFHSQHRVIKWLWEILEKDLKPEERRLFLKFVTSCSQAPLQGFKHLYPQFSIRCVEYGDDDDPGDTIGSVVRGFFAIKKKSNNDRLPTSSTCFNLLKLPNYSKKSILLEKLRYAIHAGTGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B589</accession>
    <name>A0A0N5B589_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DOCKER domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B589"/>
    <dbReference type="STRING" id="174720.A0A0N5B589"/>
    <dbReference type="WBParaSite" id="SPAL_0000123600.1">
        <property type="protein sequence ID" value="SPAL_0000123600.1"/>
        <property type="gene ID" value="SPAL_0000123600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000123600.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21849" checksum="2B7D16FDC1AEFC95" modified="2015-12-09" version="1">MKRRQKIIGKKEQILNPLEVACESLLKKADQIRKVLKAVKEASNHGGMQLDTYDKSFLDKLDLKGLQLLLQGAVQATVNAGPLAYGEAFSTIIQKQRYGEDEINRLIKAFKQLLHQCSEALRVNEVAVSSDQVEYHMMLKSSFEVLQERLNEYFGEDKMKIMGDDIVNDDSDLMEDVHNASIHILDSIAGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5P2</accession>
    <name>A0A0N5B5P2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5P2"/>
    <dbReference type="STRING" id="174720.A0A0N5B5P2"/>
    <dbReference type="WBParaSite" id="SPAL_0000138800.1">
        <property type="protein sequence ID" value="SPAL_0000138800.1"/>
        <property type="gene ID" value="SPAL_0000138800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000138800.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10649" checksum="484376913DDF2994" modified="2015-12-09" version="1">MKNTSEKSIKGDTHVKSPYLTRENPCLQFSSVIELPYPKGSHIWITVLFQNYNDRKKFHIQIPTVKLEPMKSDEILELQSGDCTDNNSTHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6E3</accession>
    <name>A0A0N5B6E3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6E3"/>
    <dbReference type="STRING" id="174720.A0A0N5B6E3"/>
    <dbReference type="ESTHER" id="strea-a0a0n5b6e3">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000163300.1">
        <property type="protein sequence ID" value="SPAL_0000163300.1"/>
        <property type="gene ID" value="SPAL_0000163300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="33"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000163300.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="68110" checksum="B398A65E34F1253B" modified="2015-12-09" version="1">MVHLLVKSSPLLIFVFLYLFYLLLSKYKAYEYPIVITSLGKLQGKNLKLQDGHVANLFLGIPYAEPPIGTNRFKKPVKKLPWKGLLTVDEYQKTCFSHVINIQNIANYSEDCLFLNIITPDLRETKKLPVVIWIHGGGYSTGGGSSFNINDISNIFTKNKIIFVTIQYRVGVLGWLYIKDNNKSMHNIGYWDQAMALNFIYDEINRFGGDKDKITILGGSAGAASAGALTISPITNHMIDKVIELSGSFLSKWSDFDIKNLEENSQLFISKMKCKNNNFDNTINCLQNKGMEDILEINKDIYDNYNTLQFGAFGPTISGEFFPDSIISGIKRSKNIVSFSGLTTEEAGYFTILGKSKKINKMILDKNSIKDLNSSFLTNFVDEKILKYTFNINNKGIRNELVEKILDFYLYKKYNNESEIDTKIIAKIYTKILSDIQFNLPCLNLAILRNTLRHTNYFYQTSYYNPNWYDEGIKDFLNTSTHTSEYWYFLGQSSTGNFITSNNDEAFRKTFNDLLINFIKSERSSDNDVLNKYLMKKKGFVKLNDRMYLPDYFIKLDKNISFSDRLPFLERYAFWDELDTYYNLNLFIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B707</accession>
    <name>A0A0N5B707_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B707"/>
    <dbReference type="STRING" id="174720.A0A0N5B707"/>
    <dbReference type="WBParaSite" id="SPAL_0000183800.1">
        <property type="protein sequence ID" value="SPAL_0000183800.1"/>
        <property type="gene ID" value="SPAL_0000183800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000119">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like calcium-binding" evidence="14">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="484"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="577"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000183800.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="78427" checksum="C4F77B372C8DD18B" modified="2015-12-09" version="1">MVISRILIFIISTFLYVGVTGNTIIIPKTTIDKAPLSQSPCNLIEEGIAINCSASLLDYVNVEKVSLHPLLSDIDKICGKLNIYKKCTKNISKNCLEFIAPKQVHLFEYLCQFPVKDSIVSEKECFMKVQTEKYMTNCFDNITYFFNSSTSNSLFHHDNGIISNSTSIVEEEKDELCRVIKSTSDCYTQTNFLKECPKAGNVEHDILTFIADKISQKGNCGIGSYHTILRRFEELELEKSIGTCNENGTCTCIKGYRGNNKTMRCEDIDECSEGKHLCSQKCINTKGSYTCECYENIFKLGEDGKSCILIDQQTQPWLFFAHGQSIWNISDDGKNFQLQRSGLQKAAMIDVDIKDKKVFYVDIETKVIEKIDIDGAFPESVQTFEVDGVEGIAVDWVARNLYTVRKSDMFVQTLDGKFRRRLYKNIFTTPRALACHSLIGKVFGTDWSSNAFIASANMDGSNFKKIITDGIVWPNALTIDIYSNKIYWADAFLDTIQSANLDGSGRKTIISDPASVPHVFGMTIYNDFVYWTDWTYRGILKANKNDGSNVTVLAQTALLPYSIKIFHKSVQPDIKNPCDEMKCSQLCLLRENATSAVCSCSDGFTLGDDGRTCNSHCDNQTEILCGGSDPRCISKRYLCDGVVHCKDSKDEENCDPRLCLPNQFQCHDNKKCISEKELCNGVSECLDNSDELYCFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B725</accession>
    <name>A0A0N5B725_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B725"/>
    <dbReference type="WBParaSite" id="SPAL_0000185400.1">
        <property type="protein sequence ID" value="SPAL_0000185400.1"/>
        <property type="gene ID" value="SPAL_0000185400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185400.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13245" checksum="F0CF53B23AAF8F99" modified="2015-12-09" version="1">MIEAFPSIHKPRKLYEMKKKDPKNIKIVNLGRQSIDRYNKENGMHSKFVDVLEAQKEYTKDSSHYALKISTTMDCGSDGRLCLEVIKSDIYRNNRKPSEVTFDVHREGDVYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7L3</accession>
    <name>A0A0N5B7L3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7L3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7L3"/>
    <dbReference type="WBParaSite" id="SPAL_0000203800.1">
        <property type="protein sequence ID" value="SPAL_0000203800.1"/>
        <property type="gene ID" value="SPAL_0000203800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894081" evidence="1">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000203800.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="16770" checksum="8BF838E668402054" modified="2015-12-09" version="1">MSLYSKIIFLIAIYLTSFYGDIHACLPVLTTPTTTTICCTPLTIATHPRIPAPAGTPAANLDECAMLQRNSAAVCPLTATLTCTRASGTTTSEIMIQLLSGNNLIRNFQGTGTSITATVNCVNGVWTTTNAAGAVTPFAQISCSQLTVSGGDVVQTVPGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B842</accession>
    <name>A0A0N5B842_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B842"/>
    <dbReference type="WBParaSite" id="SPAL_0000221500.1">
        <property type="protein sequence ID" value="SPAL_0000221500.1"/>
        <property type="gene ID" value="SPAL_0000221500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035539">
        <property type="entry name" value="DUF5387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17361">
        <property type="entry name" value="DUF5387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000221500.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24819" checksum="F820BD32B28D1F52" modified="2015-12-09" version="1">MSTTDIYVEETRDNTDNIVVLEEDLISNSGGFFEGNNTLDKIHSDSKEDGLDLEVDDNEIIPEEPLHEVVQEETENDPEDVVEGTVTVMNVNGEVGLQNDVIVSKVVKQIETQVEVNEENEGLKKPADFPDYEEIRKAKDMENEDPQTTDVRDPNVVKSGEPDEDDWAKKNARSGKKVNDLIARFNNGVTFQGAENYKTSSSYKSDYGVGKGQGQIRQSVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8D1</accession>
    <name>A0A0N5B8D1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8D1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8D1"/>
    <dbReference type="WBParaSite" id="SPAL_0000230400.1">
        <property type="protein sequence ID" value="SPAL_0000230400.1"/>
        <property type="gene ID" value="SPAL_0000230400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000230400.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46634" checksum="268CE18F0BD81D4F" modified="2015-12-09" version="1">MDVMYQKLMKNFTYPLEMSCLFENLLNEENEKKKLEHQYLDKYQWPTFLQESSLSFSLGLDFNKWSQDYENVYFIHWEGNFRDSYTADYFHITLESFKTIYQKTCILFDMFNLKKGDILCMFSPAIIQLPIIMTSAISSGIIFAPMSPEHYRNNIEIKEYLKNFPMPPKLFITIDTFYNGEEWIDCKDILDKTIQSLKKYEDVKIIVIRHGGPHTGVPPPSYTHIGRRPNYNVSCLIIEGRDFRWGELMKNIKIPLTFKTFINKVKPSDIVLYVDCTYINCLQFSILTSLHKILLEKECPSKNLHFVGAPSDCLFFITQIYTLITIKKAFLITECYINNSERIKNIFSDYELNSAGVIYHILLEKEIIELINSLQKVFITSGDETSGLDKIVNKIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8G0</accession>
    <name>A0A0N5B8G0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8G0"/>
    <dbReference type="STRING" id="174720.A0A0N5B8G0"/>
    <dbReference type="WBParaSite" id="SPAL_0000233300.1">
        <property type="protein sequence ID" value="SPAL_0000233300.1"/>
        <property type="gene ID" value="SPAL_0000233300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF22">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000233300.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60528" checksum="0353282698EB1F7D" modified="2015-12-09" version="1">MLISSKILLKFILIILFFNLSTSLLHNNSHLKCNNTKAKNKKILFYVPTLSFSHVAFNQKIAKSLADNGLDVTIILPDIDPLVKVNFSNSTSRRRINIGLDNGIFPDTLWKNPGPYEDSSLLNPKILYKLIKVSSILTYGCYNLINNKNLIQSLINENFEIGFVEQYDSCGLGLFKTLGIKNIHWLSATNIYRLQPETVGVNYPLSYVSELFSPFGDIMNFSERILNLLTAIVTEGIHTYFSKMKVTDIFKIEFPKSMGKIDNVWNIASTSQSIIANNLPLLDFSSPTSNMIYNVAGITVDKTNNELDERFKKITQQKSYFFLVTFGSIAKTSDMPFIMRYSLFNAFEKFPNITFIVKFENQKKEIVKHSENVFLVKWLPQIALMKQKNYKGIITHGGWSSMIETLTYGKPMILMPLFADHGKNSKIIEQKKLGILIDKMNINLNTFSDSLTELIDNPTYDFNCKRYALMLQKTIPIEKEKLIYHVVKNSLKNNRNIYLKIKSPNIIKIYFVDLVFILFLLIYICKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8U6</accession>
    <name>A0A0N5B8U6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8U6"/>
    <dbReference type="STRING" id="174720.A0A0N5B8U6"/>
    <dbReference type="WBParaSite" id="SPAL_0000246900.1">
        <property type="protein sequence ID" value="SPAL_0000246900.1"/>
        <property type="gene ID" value="SPAL_0000246900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF375">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="499"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="844"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000246900.1"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119136" checksum="162D7B94C2D9D775" modified="2015-12-09" version="1">MSTSFFACAEVKKNVLNPSNIITSFGIPSFNDAARFPFKNLTVKIGILIPEDNNETSSSVGYHRTASAITVGYKDLLDGGFIDQDKLNFDFLFYQINCTGLLGTKYAIELLIVNEVDVIIAPPCDGLSNFISFVYSAYNRPVYLWGSTVNSLISTSNDIQTTVSTSISYNDYTYATTDVLNYFKWKYIAVVYMNHPFFNKCPQFQSDFIANALKDTNIIIQYVAEVNTSASSMTAVLKELKQYARIVVACIPTLKYKRQFMLAAFDENMINDEYLYIFSVVNNFVLNNNVSGVMAISEGEEMPNDGRDEDATIAFNNVFMIIKENKNQKTDLNIFTNQIKRYMTEWPVNCNDSLCLSNLNDSNFQSSSFAPYLADTMILYGLALNKTLSTEPLRYNDGVLIRNNSLHEFDGYSGSLTFGEDGIRMGIFDLVAFNSSSNLVFLFELYEGNEEQFTVEPLFETEEEIWFNRLNKKRPTDEPECGFTNNDCKNPFTQQYENFNLNREVNGNNVKKLHDENIIEDDEVNTIGYFYKEEIVVGKKFHKHLSIDNKIRSHLRMLREIDHENLNKFIGLTEYKQYVIPIWKYCSRGSLKDWALNANIDLEPFYIVSIMDGIASGISFIHNSKIGYHGRLTSSTCLLDNQYQVKITNFGINLLAENFQRTENEQLYTAPELLRTSSYSGTKEGDIYSFAIISSELLNKAPAWFDKYEEMLTHEIIMKIKKSRLGNFRPIIHDKYEEKWVKDITKLVKECWSEDPMSRKKIGVVKTIIKKAVKVKNINLMDYMFQKTENYAAELEEDVRNRTRELYEEKKKCDILLYRMMPKSVVEKLKSGEDVQPEYFESATVFFSDVVGFTNLCAQCTPLQVVSFLNQLYSRFDELIEKYDAYKVETIGDAYLVVSGIPIRNGNKHGEMIANMALGFMESLPSFKLSFLPDYRLNLRIGLHTGSVVAGVVGLQMPRYCLFGDTVNTASRMESNGMPGCIHMSSDMYGLLSELGGFEMECRGEVMIKGKGLLKTYWLIGNSNDEFRIVMKEKSSTNTNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8V7</accession>
    <name>A0A0N5B8V7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8V7"/>
    <dbReference type="WBParaSite" id="SPAL_0000248000.1">
        <property type="protein sequence ID" value="SPAL_0000248000.1"/>
        <property type="gene ID" value="SPAL_0000248000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000248000.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29398" checksum="18CB79543E3EFDB2" modified="2015-12-09" version="1">MEHKKGKTSSEEEEGKDDNNGTCQQKPSSPGPGSDSSKSSVTSEYTTAPSSLSSGKSSVICSYSTASSSKVSGKSSTTSEYSTPPSSKASGKEQEITPSITAEVEKSIVKRNEIFQKLATVELPNYKFYRLRDQDKDKITIGKSLSISTNVHQFKFSDNLYVDLYSVHFLNSEKKIDEKIRQSKKRDVVMKILYREIKNKSDLNNFVYDDHNLLYVKSGIFKEKKYEYCVDPDARRAVYVRFEKAKHLPIVLSNTDNTTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B902</accession>
    <name>A0A0N5B902_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B902"/>
    <dbReference type="WBParaSite" id="SPAL_0000252400.1">
        <property type="protein sequence ID" value="SPAL_0000252400.1"/>
        <property type="gene ID" value="SPAL_0000252400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000252400.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23971" checksum="E0515552A58F574B" modified="2015-12-09" version="1">XYILSTADRFTNESYTNTTLSGRQNLLQFIKEKLKPTPTDGASTSKQFATLKIGTIVYKKIVNAHKNNEQFHGPYRILEHLHGDTYLIGMVTRSNRKTGQIERCNARFLKLASLAIQNTLNDESHILDNDNHQNTRVTSFPQETIIKKGRGRPRKVLPTNNETPNTDEIIIQPKKGRGRPKKLVSMNNSNITTIDPQTQQPTRGRGRPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA94</accession>
    <name>A0A0N5BA94_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA94"/>
    <dbReference type="STRING" id="174720.A0A0N5BA94"/>
    <dbReference type="WBParaSite" id="SPAL_0000296400.1">
        <property type="protein sequence ID" value="SPAL_0000296400.1"/>
        <property type="gene ID" value="SPAL_0000296400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000296400.1"/>
        </source>
    </evidence>
    <sequence length="829" mass="95945" checksum="7B74E5A0864AAAB6" modified="2015-12-09" version="1">MNNKQCFKLASQYPIGVPKTAYRLGITILLNSIEQSYAQNILSLSEAEKITWLVTRLINLPDLTYTTLMEIVKNFTHNDKFIEFFKNDILNYEMRVSTKSKSNLEDGKAQEIKFAKSRSVIGYFLRGIEASECFSTPGQDFYVLDSFEHWRKQDDIEAYKPYIKISEFYADKKDVILNFLYSYISHFTKNPYEFPIYFNLPASKLICDIIPHDHIVSLINRQCLLMQLCPKNALPTKCVHMMKSILQEEYPTITKTSFLLMLNALRCGNYVEAESYGKRYFNEASLIIKDRSNLVTSFYIPEKKPLIYGPLICSRIYKLQKAKRNCQALIEEATTHSHASRDLIGVRACTLEKILSENMINNDLVAEAELLMVKYSMGKYGDTADKMFFIDGIGNDDNIDEDAALNQTIQELEEVYPVLHCKEFNFIINDHDKKKLEHCFEYDADPDDAEAFFHQMAKHFLYIKAIEWSKIGKNKHLCAKLFEIILESDFGSDRFIQTKLLKDAALVALSTMSLEKGYYKEALFKAGIALNSITEPLRNIPSLATEIHAQAAANAAISFAYSGNYDGALKVLKKYEEYFPKDSIGESYTQLRLTKLLIQFDYNFFKGEWETLRVLLEEINLYNYFEYDMRVGILDCCTNDVSQAISRLNNLIGNFSNQNATSLQYIRCLMVQGQMYLYIKNWEMAFDSFKKALRLAQDNGFRNLCTMLIRRMATSMLKVGRIQQAGALLMNHRSQMESELPVIEQALYHLTMYMHAECVGTPEAERYLTDAVRVLEPFNLPLLQTCIYRYLINYKKCHKKNSAHEVKVLEDKLKKFDLPKERDLPHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAW3</accession>
    <name>A0A0N5BAW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Orcokinin peptides type B</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAW3"/>
    <dbReference type="WBParaSite" id="SPAL_0000317700.1">
        <property type="protein sequence ID" value="SPAL_0000317700.1"/>
        <property type="gene ID" value="SPAL_0000317700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040384">
        <property type="entry name" value="ORCKA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864:SF1">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864">
        <property type="entry name" value="NEUROPEPTIDE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894100" evidence="1">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000317700.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17867" checksum="6489562646689DCF" modified="2015-12-09" version="1">MMTNSYCNSKNFLKLLLTFLICSSVVAAYYPEYGFRRQMRALDSIEGSDFGFKKRALDGLEGEGFGLKKRALDSIEGSDFGFKKRALDGLEGEGFGLKKRALDSIEGEGFGLKKRALDSIEGSDFGFKKRALDGLEGEGFGLKKRISKLGNRYLAFLRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB48</accession>
    <name>A0A0N5BB48_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB48"/>
    <dbReference type="WBParaSite" id="SPAL_0000325800.1">
        <property type="protein sequence ID" value="SPAL_0000325800.1"/>
        <property type="gene ID" value="SPAL_0000325800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="134"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000325800.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48002" checksum="DC4C0FB8FBECBACB" modified="2016-05-11" version="2">MPSHRCWIWRCKSKFLFNLYFIFLIQLTRLRIQQETREELSEGSKKSFDEHQKAMEQLVKLSSQIHGVKPPKDDDKFEMGPMENPSMYQGDMILNKHQAEYLLDEAKMRLEAKQANKTGPEAEKEIVDKLKKNRAFRKNAPTKWQFPIPYYIDGQVQHAVVDNAIKGIEKETCIRFQKSQSFKGRHGLRIFPGRGCFSNIGPISADNVQDVSIGQGCEWNGIVQHEVSHALGLFHEQSRPDRDDYININLNNVAPNQRHNYDKTTLAESESFGIPYDYGSTMQYDKKSFSANGQLTMIPKNPLYLNTIGQFDKLQFNDVKLLNTVYCQDKCKGGIKCSNGGYEDPNRCGQCKCPFMLGGPTCSEVAKNPPNCGQGNSLEATPQEKTLDIKGGKRCVYEIKGNGKKVQIRIELGIFYPSERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBG1</accession>
    <name>A0A0N5BBG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sidekick family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BBG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000337000.1">
        <property type="protein sequence ID" value="SPAL_0000337000.1"/>
        <property type="gene ID" value="SPAL_0000337000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2054"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="343"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="454"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="545"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="649"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="755"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="858"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="964"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1062"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1162"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1298"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1401"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1514"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1611"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1718"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1820"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2282"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2282"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2308"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2334"/>
            <end position="2347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000337000.1"/>
        </source>
    </evidence>
    <sequence length="2364" mass="267140" checksum="C43232166E9B25A6" modified="2015-12-09" version="1">MTYLWNICRCKIPNFIWIFLLYFLIVFLKTSSCNIVSLNSNDIYDKKEPRYFTPFIGTSLTLQCPLQLSIDDKVGWRKDDKSIDNNESYEITSNKLTIPFIEPKHTGNYRCYVETPHGTILSHIIYVYVKYFRKLITMPTSFYQKTIHKTKYVILKTPPVEASNEGEIKWTWHHNGQHITSNETHFISTLNGDLIILPSEGIFGNYIVEADYGSVKEVSNTYNVEEIKSKIPPDNKFFLIAKPHDVIVSQRNLTLIFECMPNSWKNIKIDWFLDGKIITLTKNERKSLKISQFNRTLTIYDPFVTLTRRNTVDSRSIKCRASSTIDDKILDYGEGKITLFEEPTIDTTIIPKKITLGNRTSLKLHCKILKGWPRPKYIWRFNGKEIITTHSGYLKIDSVSDKNLGVYQCDAVNIVGSDTITTIIQKNDDEEVKEKLTKKEGTFQRFHDDIKDSTNIYITKKPVSKAISSGNDITLTCELNGNGDTIWKFGDSIIKMNDNKYTITRKSLTIHSVQSKDSGDYTCLAKNLNGQIVDEASAVISVISSNIIEYGPSNQSMLIGSNIEMPCKLSQDYLTSSGVSVTWYWNNKIIPFQGDILHRMTIKNDNSLTINQVGPDNIGEYRCKVVTDDGKEEIVSAWLKIIEKPSMPHGVNVELINTTLPTKVKVTWQSGFDGNSPLIKHSIEMRTMGSAGIWSNWETIVENVPTEMCCSALIDNLKPSSTAEFRVIAFNRHGAGKPSIPSKQLFIPQQPPAAAPRNVAASARSSTSVMVYWQPPPSEQWNGDILGYYVRYRLAGYATADWNVKNVSNNQERYVLLEPLITWRDYEIQVAAYNDRGLGVYSTPPFVVTTLEGIPLQSPRNIDVDVINSTSINVSFDAPEQQMVPGQILGYRIEMWKDFYSSNGDIEPTRVIPLMPNYGRINSIITGLDKFGHYNLTILAFTSAGDGPRSEAIGVVTEQDLPGPVKGLKFDQVLFSSVTVIWEPPTEKNGIITHYIVRCWKQGSPETLRTFDMSPNETSVTIEGLSAQTKFIVDIVAFTEIGSGEVVEAKFESGVPPELPGKATSLRVSSITARTCILDFIPGFDGHTIIQHWHVEAQIGFSNTFIPIFNISAPRAKSFKITNLRPNTRYILRLIAENIKGYGEPSAPSDVFFTEKTVPEHPPEKVEAEPVMMNSIQIFWNLLPPSSWNGDLLGYVIQYRPLELTKPKNKEAKITANGFIEEEDYEDGADFEEEALKYYPGKWIEIRTQNTKISDFILSNLKAFTLYEVQVLAENTNGRSEPSPKITAKTYENIPSSGPKNIKINLIGGRSINVTWDEIDTQSCNGIILGYKINVYPEDKKFQKKFNKTIDIKGLDAKSYIITNLKPYTKYFIEMLGYTIVGDGISSIPLSITTPSDVPDEPLDVAFSYVSDTEVRLKWMPPENGNGIISGYSIRYWKYGTPDENAINTQIPNSIYWFTATGLHPNTTYYFGVQAQNENSGWGQESIVKVLTTSLRYPQPIPGMLEQNKEIMESPTEIHFKWVNPNLDNRSVSLEESPVRFVQIEYKSMNDDEFILLPAHIAVTKRSTSIGNLLPNTKYKARMKFIGDFEESPWSPETNWITTPQTDPLGYPSNFIVKPYQSTSINLQWDSLPKNKWNSDVIGYRIEYKEYPSNGSFKIEELPLSNKIPSDGIITHILGHLTSFKHYIVRIQAFNKIGNSQFTSPRFVFVGYSIPKQKINDLVGKSITPTSITLDWKEWNKLEDDFISGYKIRYVPLVDMLKKEERNVEEEILITEDNHIILNDLKKYTEYQISVCGFNRAGDGESSIVRLKTLEGIPGVVSNFKFKDIMTDSVNVTWDEPVEPNGIILGYLVSYRASESNGYNQDKMFRVKDNYVLLTNLTENIHYTVSIKAESNQGFGPPSTSEVRIGYGNTGTPNPPNKPKGLLKSYGIVLSWDNENNDSVKGFVIQGKRLSTFSNTTKEPSDLDIISSPIRIKRSTNTTINHLLGEWINLYNIDSIDNEYEINYEDLQPSSIYVFRVLLKNDIGVGNPSEESEHLLTPAFTKRVIFYKEWWFIPVTAAILALFLIILTIILCRLIVVKRKNKYTQKNKESMIGSSLNFVEGTRVNYELANVNERRNDLLPTRPNTHNSWLSNDLPDNTLYGSIHSGGDTQSRRSIMSPSVGLQALYGSLATDKITMNNMESSTMVLSSFKPPSPSTSFLPNLAGSVNEIYNRGRNEDIPVRSMYEESVCIDQTDRESLGYSTPTPLPTGELPHEQNYYEQCIRRVPQSTITYASSETYSLASSKPSNTNNHYYTTSYHPKESTFLPSQKNNDRQSSPSENLSSASTIQDPGISLRSSVPSSPSTKYKAANLPKNGLSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC24</accession>
    <name>A0A0N5BC24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC24"/>
    <dbReference type="WBParaSite" id="SPAL_0000357366.1">
        <property type="protein sequence ID" value="SPAL_0000357366.1"/>
        <property type="gene ID" value="SPAL_0000357366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000357366.1"/>
        </source>
    </evidence>
    <sequence length="52" mass="6346" checksum="4C1E84544A78AD69" modified="2015-12-09" version="1">MNLRYTMICLHLRNMIKKKLRKYQLSYHLKIIILCSVKHNLESLMQIESVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC77</accession>
    <name>A0A0N5BC77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC77"/>
    <dbReference type="STRING" id="174720.A0A0N5BC77"/>
    <dbReference type="WBParaSite" id="SPAL_0000362400.1">
        <property type="protein sequence ID" value="SPAL_0000362400.1"/>
        <property type="gene ID" value="SPAL_0000362400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1 N-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000362400.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="72424" checksum="FB343C7107A9D281" modified="2015-12-09" version="1">MPIKIAGSEELEKDKDVYYIQPLEGYCAKFKECQFEEGVVNVEGMIMKQQNNLKFFINVCHCVEIPPPLDDYTEDILSEKLDSNMEDVKIPMSVSELHACQTNKNEDALKVDVLINSSFYGSRVADSLFIRQFIIVVACELISEKHKITLDPSESIELKNKKHIGELMIQKVRKTPAEAGIKEIKDEKIILLDDENKGDGVTFDEFEKIVHGKEDLPNVNMYINQATRILKVNITLSEDVTKEEDIMVKMNSDRIVVIVHKKSKAAEMYSRFLMDYNKAKLKFDSTSRLLSISVPVIMPSIPLFGDTFVQSHEDEFMESSDMNFAMLTDVNSQRAIHTIINKSLNERLLLLICDRVCHEEREEIPKVIREFSKDLGIRKTNSLHFHFLLKKEKIPHYNIENFVGNSTMSLLYFIGEKAYPYRGPLDSKKDIYQFLMDREQRNMRKLKTYEDLDLFLSSINNDIDSNFYTLYLNFKNYKKCGPFGINSFENAVKSTDLEVVKPIKMEVEETKEILVIIEMRLSQVKHKQCPTLLLIHKGKYKEIPLIFSPRIIRKFIEYAVDNYYEIEDTWTKIGEPLTYIQLQYLVDEHNIQDLQYNKKFIAAAVIGGFAILLLGFSIFWALNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCG7</accession>
    <name>A0A0N5BCG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCG7"/>
    <dbReference type="WBParaSite" id="SPAL_0000371500.1">
        <property type="protein sequence ID" value="SPAL_0000371500.1"/>
        <property type="gene ID" value="SPAL_0000371500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894154" evidence="2">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000371500.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13891" checksum="6DFACD1420ABE41D" modified="2015-12-09" version="1">MTKFSAKVIFICLVILIIRINFSSQFPFNPNFQPGFQNSMVSQDYSNFMLELKVDKLIENDEQNFEALEKYITGINNTLETLIKLLEHLFTAPPSATSKPTKGTKSPKTKKPTKSPKSKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCT3</accession>
    <name>A0A0N5BCT3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCT3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCT3"/>
    <dbReference type="WBParaSite" id="SPAL_0000382800.1">
        <property type="protein sequence ID" value="SPAL_0000382800.1"/>
        <property type="gene ID" value="SPAL_0000382800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382800.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="28493" checksum="7B4702D60F70BF14" modified="2015-12-09" version="1">MDLDARIKAYRFVAYSAVTFSIVAVISVCITLPMVNNYVNNVKRSINSEISFCKTTAKDIWSEVNTLKNLQPHNRTARSGGYSEQPSVAAAGGGGGCNSCCKPGPPGAGGKPGKPGKPGKPGAPGAPGAPGKAAAAPCEPATPPPCQPCPPGPPGPPGPPGPAGDAGGPGEPGSPGQDGTPGPAGPPGPPGPPGNDGQPGAPGQPGPDGASEDAGPGPAGPPGPPGPPGNPGAPGNPGADGGAGPAGPKGPPGPPGPPGSDGNPGTPGAPGEAGGPGEKGICPKYCAIDGGVFFEDGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF2</accession>
    <name>A0A0N5BDF2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF2"/>
    <dbReference type="STRING" id="174720.A0A0N5BDF2"/>
    <dbReference type="WBParaSite" id="SPAL_0000403800.1">
        <property type="protein sequence ID" value="SPAL_0000403800.1"/>
        <property type="gene ID" value="SPAL_0000403800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19337">
        <property type="entry name" value="Wnt_Wnt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF77">
        <property type="entry name" value="PROTEIN WNT-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000403800.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42796" checksum="2727771FC102205B" modified="2015-12-09" version="1">MISFFYYHFYTPILLYLSSYYLLTHGTLVDEPAWWTSLHAFGSYNYKVNRDLRPSCMALEGLSPGQARICELFKDHMPAVNQGATLAMEECTHQFKNDRWNCSAPPTNHTTPSINKAGTREAAFTHAILAAAVTYEIGRKCRLGYIESCGCANTPKPNGLKEDWSWSGCGDNIDYGYRFSKDFIDVREKENSMANNEARGVSLMNRWNNDVGRKILKRHTKPKCKCHGVSGSCNLKTCWMQMPSIRQIGNILQSKYRSARRIQINSRGNMQIVAHVEKRGIEKSKKTRSQLQTELVFLQNSPDYCRSDNKTGTIGTEGRICNKDSQGPDSCDLLCCGRGYNSYIEEVETKCNCKFQWCCKVVCDICKDQTYIHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE92</accession>
    <name>A0A0N5BE92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-galactose translocator</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE92"/>
    <dbReference type="STRING" id="174720.A0A0N5BE92"/>
    <dbReference type="WBParaSite" id="SPAL_0000431500.1">
        <property type="protein sequence ID" value="SPAL_0000431500.1"/>
        <property type="gene ID" value="SPAL_0000431500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000431500.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45306" checksum="F027260080A8C1AC" modified="2015-12-09" version="1">MSLNNKNLTSSNSKDIYTFNSNCSEKSDDDSEKFNLTDGNWFLKFKNLLPIKTLSILFFIFHGTLSVCMLRYVRFRKVEYMFIAPVALMTGEFFKIFLSTIFLTIENKSLIDAAKILHLETMINWKSFLKTSIPAFCYAIQNLLYYYAISYLDATLLLVLQQIKILTTAFFTVLLLKRKLSTIQWLSMVVLIVGIILVQIKFPSIKNSNIVNNSTNPNNTIETTTHYYPLPNPLHIPPQIIGLIMVLTGTTIAGFVGTFLEKLFKSSVTSIWARNFQLSIFSIPVHLTTAFLSEYNKISTHGLFIGFDYWVILMAFIFGVHGMVVAILLKHASSILKCFASGFVIILTALVSISLFDKWPSYLMIIGTLVIFVAVYMYTKYPYRSKIRTNPTIVEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFV2</accession>
    <name>A0A0N5BFV2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 13">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFV2"/>
    <dbReference type="STRING" id="174720.A0A0N5BFV2"/>
    <dbReference type="WBParaSite" id="SPAL_0000486400.1">
        <property type="protein sequence ID" value="SPAL_0000486400.1"/>
        <property type="gene ID" value="SPAL_0000486400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000053">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="41"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000486400.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23808" checksum="8C6BAC2D1E0CF330" modified="2015-12-09" version="1">MSSSEQIISIPDNLEFSIDSFITPGCYEGDLSSIIIPEGLVVDRVKKLAHEIHSVLGDVPLIMLCILKGSYRFFTTLVDELTIARRNCSTSLTVEFIRAKSYEGTSSTGHLQIIGLESLDELKGKNIIIVEDIVDSGLTLHRLIKTVNDNGATNVWTAILLSKRVKRVKEVPENFVAFSIPDKFIVGYGLDYNQKFRDLNHIAAMSESGIVKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGA3</accession>
    <name>A0A0N5BGA3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitellogenin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BGA3"/>
    <dbReference type="WBParaSite" id="SPAL_0000501200.1">
        <property type="protein sequence ID" value="SPAL_0000501200.1"/>
        <property type="gene ID" value="SPAL_0000501200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000501200.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21212" checksum="DA0B21175D488456" modified="2015-12-09" version="1">XNICTKKFPEQYHKVTSITSKGKVNIKRSFDPLLDITDRFGNKVNNDFCVTYNPYLSLKYNSHINVKICESVLSPKYLFKYTHKSNGDKISADVVETVESKDEVKLHIDGRYVGPSEAVWRIMEYPILYKDWTVVRLAVHLINEDCTVADEMNNGNNNCFKAEKGYKSTLVAYYNLNKNDINAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGT1</accession>
    <name>A0A0N5BGT1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGT1"/>
    <dbReference type="STRING" id="174720.A0A0N5BGT1"/>
    <dbReference type="WBParaSite" id="SPAL_0000518100.2">
        <property type="protein sequence ID" value="SPAL_0000518100.2"/>
        <property type="gene ID" value="SPAL_0000518100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000518100.2"/>
        </source>
    </evidence>
    <sequence length="476" mass="55762" checksum="F619B470F815C492" modified="2015-12-09" version="1">MSQLRSTEDRSIDDCVHGFIPIGRLANLIIDTKYFDRTKEIHQTGMAKIVYPCAEHSRKTHMLGTFFLSLCVLEKLVKSQPNLKINKTDILCVSIAALCHDIGHGPYSHLYDGPFMNAVNKESNFKHEIASVEILKKLFQDYPDIKAEFDEYLEEKDYTFIYECINPKFPFMVDGKWLLKGRGKDKSFLYDIVSNVHTGIDVDRFDYFLRDSFFCSIKGSQFDVDVLHRIIDYSRVVYDSKLGYNRIGYAFKVKNCINAVFETRKFLFETLYFHKTCLSYEHILLKAWIEADKYLEFKTKKGDKLKLSTLYKDWELYSLVTEHVVNALIQFYPDDRLSKSRELLDRLRDRKLPKAVFYLQDDKLDGMEEKFIKEWIMENSKENLDEEKLFVKIRRIHSGKGIHKNPMDDVLFYNHKDIKNNNIVDEGIASKNKHKGTTEELPGGKVDAYIYTDYGIDTCERNAIIAAARQFEETFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGT4</accession>
    <name>A0A0N5BGT4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Akirin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGT4"/>
    <dbReference type="STRING" id="174720.A0A0N5BGT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000518400.1">
        <property type="protein sequence ID" value="SPAL_0000518400.1"/>
        <property type="gene ID" value="SPAL_0000518400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000518400.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26108" checksum="4E09FFBEBBB26EF9" modified="2015-12-09" version="1">MTCGLALKRPHDYEAYLSPDNSIEAKRSRGSAYCSPFRPQLGTLAASLPMNSALNLLKDNETKDNSIFAGIERSCRLTDQQISRFLNTEITALNKRKRLIAKRKDKNVEDSSCETPNNSSVKAVSAYTRFREAGSPSSGSDSDSDSLLIGGKRKCNRRGDSLNEQLYTYEEMFSIINRLLKQQEINLRSEYEVTIRKKLEEQHEQYCQFAEEQFQRNNKNDHSYSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKF7</accession>
    <name>A0A0N5BKF7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Raw</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKF7"/>
    <dbReference type="STRING" id="174720.A0A0N5BKF7"/>
    <dbReference type="WBParaSite" id="SPAL_0000641400.1">
        <property type="protein sequence ID" value="SPAL_0000641400.1"/>
        <property type="gene ID" value="SPAL_0000641400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300:SF1">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000641400.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="83439" checksum="EFC9CB5A512C99E2" modified="2015-12-09" version="1">MTTNKIKNLFYHVGLLSQLPEDLRPPSPSEKYSKSMSDNKKNGWKILSTLSNSFSNSFENKEYNDIIHEEGTSSSIDGSGSNEADDSLDFDQNSVKNLIKRILSVKSLSLSYKDSISSDIPNQESGYIHYDVFLGGSCGHTIWRRSLVIPYLNKRDISYYDPQRPVWTESMIYEEAIAKENSSLFLYVLDPETINAVSFLEIAYFASRKTPKLVVVFLDKKEWKGKAHPLDLPDRQRTCDLIELILTRHSVPLLTSINEALDYVDDMIIGDKEWKAAMKNKKQRLPFLKIQIHRSFLNFKKKIFSTNILFSFCKRNKSNFSNNYNNNNNEIDNIYYCKYFTILLLIETIILIVTLLTFSSYIFPTILSDLYIIFIFLILLIFINTSFIYGMSMIQRFIKKLNYNRYKIKEKSLILPNPPIMKTKCFVLNEHGERIVENGKSHSLLYHETIGNGKRNETNFQDITSSCNNKYNNYNKYDRNLKTKDIATDECFSKPKRQSITGSLIRQSPIGYDVFLSSSSSNELDWITQKAIPILEKFNLSHISFSNCVSEMKMPLLHSSSHILYYIPSYKTFLSGMIEVAYYIGQSDLHVTVCVPSEAECLLLNYNNNPDLDPQTIAAVEKRNDCYKMAFTYLKDMANRSQVKVYTNVEDAIKHIVLKEKRKLKLRKSHNFETLRNNKELELNSSNFVFDFENKLNCSMITGSQSEDQLSYFSGSLVNNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLH4</accession>
    <name>A0A0N5BLH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IRF-2BP1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLH4"/>
    <dbReference type="STRING" id="174720.A0A0N5BLH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000677000.1">
        <property type="protein sequence ID" value="SPAL_0000677000.1"/>
        <property type="gene ID" value="SPAL_0000677000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1580:FF:000001">
        <property type="entry name" value="interferon regulatory factor 2-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="5">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="6">
        <location>
            <begin position="366"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000677000.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="54996" checksum="0FFB0100A63755F2" modified="2015-12-09" version="1">MIHSSTNNSISTPLPRPTPTNALPSAVTLNLPQNNSTSSLSNAALQHQLLMFSKQHCFLCDYPRMPWAMCPDYTEPICRGCVNYEGAEKVEATIERVKQMKRAHMALLAFETPSPTAGTTANKFKESLTNGGLISGANPPGRFSPPAAIATRTPSSSATSIPPANNPPGATQPLPPGVPLHLAQFNQLSEVLAQQQRGLVATTRANNPFTGLEDINNLNQLRSISNLLHPSSATNNPFNLSLVGVPGLTTTTGNITNLFQNPLTSVTTNGLGHSQVPTIGSNNGGGVKREHPDDDIKLEAYAAKIHRGDNQTNSLSPISTNSPDNATFPPSLANVALLHRQARLDANRRRFPEIGNLPAFQRENVLRCTTCNQRLEDTHFVQCPSEDDHKFCFPCSKKYIRGNAASHEVYCPSGKKCPLPRNSTPWTFMPNEIATILGDDYDQFKKEKDNFLRVSTTTSAQSGKSSTSSSVSVSECEGQSPKSSISLTNGGTELLTNSVKQQNQAVTAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLR6</accession>
    <name>A0A0N5BLR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cystinosin homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLR6"/>
    <dbReference type="STRING" id="174720.A0A0N5BLR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000686200.1">
        <property type="protein sequence ID" value="SPAL_0000686200.1"/>
        <property type="gene ID" value="SPAL_0000686200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894482" evidence="10">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000686200.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47202" checksum="43262A3AA4112720" modified="2015-12-09" version="1">MSRIPYFIIILFIYCVLSKSDEVIRSEDIEFPSRLIDIELDNYEDIFFKAKIPENTSVSFSLTYHDNIVNVIPRNFTLTHKDNIKLIKIEGKKLKSISYIDVTAFQNYSTKNDTIEVIKDSFIRVRIFQSTTIDTLIFVTGWIYFSMWSFSFYPQIYLNFKRKSVVGLNFDFLFINIIGFVCYAIYNVFMFWHPTIEEQYQQKYERSLNPVLLNDVIFSLHALFISALVIIQCFFFDSGKQKVSYTCYCYSSFLIVAGIGSIYFPINNIINWLEYLNILSYIKMATTLSKYIPQILSNYRRKSVDGWSIGVVICDFTGGLMANIQMILQAMNTDDWTGFLGNPVKFGLGFSSMLFDIVFMIQNFCLYPKKQIKDIEELYYSTEINEPDTAESSLASSMASTIAFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM43</accession>
    <name>A0A0N5BM43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P27 family phage terminase small subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM43"/>
    <dbReference type="STRING" id="174720.A0A0N5BM43"/>
    <dbReference type="WBParaSite" id="SPAL_0000698600.1">
        <property type="protein sequence ID" value="SPAL_0000698600.1"/>
        <property type="gene ID" value="SPAL_0000698600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000698600.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15462" checksum="71FFEFB71C9F2E5D" modified="2015-12-09" version="1">MNPLKRKTEMSLSPHDEKIVASELESLAQNLGLPKGTTQDETISILYFYIKNAVAKGQLKKVVERKAKDEKVTVMSVNNVPLGMRTSGDKKIDTLAKIVRLKYLEQSRDIQESVNETINKAQALTADPKTNMSLAKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP84</accession>
    <name>A0A0N5BP84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S15a</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP84"/>
    <dbReference type="STRING" id="174720.A0A0N5BP84"/>
    <dbReference type="WBParaSite" id="SPAL_0000771100.1">
        <property type="protein sequence ID" value="SPAL_0000771100.1"/>
        <property type="gene ID" value="SPAL_0000771100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000771100.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17597" checksum="73F104998B6EB6FC" modified="2015-12-09" version="1">MIFVLKSNIIFFKSLVRFSYQSLKMVCMNVLADALKRINNAEKRGKRQVILRPSSKVIVKFLTVMMKHGYIGEFEVIDDHRAGKIVVNLTGRINKCSVVSPRFDIAHKDIERWTTTLLPSRQFGLIVLTTSAGIMDHEEARKKHVGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPA0</accession>
    <name>A0A0N5BPA0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPA0"/>
    <dbReference type="STRING" id="174720.A0A0N5BPA0"/>
    <dbReference type="WBParaSite" id="SPAL_0000772700.1">
        <property type="protein sequence ID" value="SPAL_0000772700.1"/>
        <property type="gene ID" value="SPAL_0000772700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000772700.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39590" checksum="34D39D4F37EF020B" modified="2015-12-09" version="1">MSSIKSSMESDGQFGAKKNIERDSFIWTIEKSSISRLTGKETKMSPFFDSKNNDTVQWNLQIHQNDVSSNNENYISLSLVLIDVNCIEVTALCSFYVLSVDGEKKHKKVMSIKKFNDDIRIHTCKQFLKRDILHRNDNKLFPNGNLIVGCEIFYYYGTINTVAISTNNNLNGSLNVLLNDIADMLGSSELSDCVIKVGDSEIKVHKFVLASRSEVFSLILTNEDYKSNPNVIKINDFRLEVVKEMITYLYTGKSPNMDKMACEMLEIGEEYKLGQLKLMAEESLLHSLSIKNVCYYLVCSEVYSGGILQEWCLRFIYLHAKEIIDTKGWGKVVNAYPLLAAKLLSIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPD0</accession>
    <name>A0A0N5BPD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPD0"/>
    <dbReference type="WBParaSite" id="SPAL_0000775600.1">
        <property type="protein sequence ID" value="SPAL_0000775600.1"/>
        <property type="gene ID" value="SPAL_0000775600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000775600.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="42271" checksum="EE26324CA14D7036" modified="2015-12-09" version="1">MMYYIIVFIFYIHFINGYESLVKHNQIIPPEVSTHLKIKICSHERNPLQHDVMLYFPEVVRFCASLHTNKNKRLLDREKQKTTFIEPKVVIKFQAINSTNQCSITFTGYQTEYRFSPDLGYYSACQKSISQYVSSLVDNESPVWTPTNHQCPIQDLPKTIEDYMACDLLTNNWYQLSFFSTIRFETYKNRLYHKHFSNYTANYIFKPDFIVHRTGDETEYLKTLVDFKVIHENCDIVKYLVKIDKDWSLPIKAYFEYRIVHNEKAKHFQKIGNGTIQHWYSGEFKMLKDPWKHELCIKFSWKGSRTKYRMCEVIADYNECPPILLTSNNKTKNNNFYCITFIILIFISYIMTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ60</accession>
    <name>A0A0N5BQ60_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ60"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ60"/>
    <dbReference type="WBParaSite" id="SPAL_0000803000.1">
        <property type="protein sequence ID" value="SPAL_0000803000.1"/>
        <property type="gene ID" value="SPAL_0000803000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF93">
        <property type="entry name" value="EYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="73"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="155"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="424"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="838"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="881"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000803000.1"/>
        </source>
    </evidence>
    <sequence length="1082" mass="122440" checksum="CEF0D7B70E14EE94" modified="2015-12-09" version="1">MILFYHHICQFLRKLYIIRLTGEIKVIIQKGKDDHYNVNKNVPYGNKYVKVDDKTKNDMIFEVKPQGVVKPAGTNVQLYCGDNGYSIIDKRKNIKKNVKWRKVHDIMPFSYKIDNNGILSINNIRIKDSGLYECIEQQVDGKFSPSKYVLLTVTQLVPRFDGKSYLLLQPISPEQWRDLSMNITVKPTIKDGIILYVEKNSGQYKTPENYHEIKLKNGKVVYDYDIGNGKFNITSGKEIQLNEWSTITIKNDENMATLTVNNENQITFENDGQKIYENIPSSSLYVGGKEIPDELRNGKITDVDHYFVGSISQITVSNKTFDIGSNVVRVHGTVQQSKICSPNPCRNNGQCHTANVLMGFVCHCREGYIGDYCEVKNNICNGNLTCQEGICSIINSEEKCICPYGRRGKHCEIEDTKFLDSYVKSIEFNGRTSFIKIPIKNINDDYSIQMNIKFSNLDDNQIIAHISDSGREKNKEYVNIGVEDNKFSVVQGTKISKKKKIDKTRLINDDVHKIEITKKNDKKIVTIDEKIILTGKIDDSNNVISSAEDINGYIIIGQIPPGLSRFSLKTLAEIDNSNLETIPNVPFGFNGCLINITFNGKYIPTTDIINYNSGDIKKCGEKEDGGLLYPSFLEDNYTILNEYNNVDSFMKNISTTSKTLESEITLTESKEDTDLNIISTTSLYDVYPHLNTVNNYRLPQSGETDDSVEKDVTKEVGDKGYEEIMDKFITSTISYDNSTMTDEIIDKKKEEITTSISTNDIISIDNTTAYVSIEEKKSSEIGLVLPTDSSSVEENNISDESYQTYSKEEDKYIIKTTPHFDVDFEDESLKEIPENVKIIDRCEYDTCGDNGICEEVNSTHIACSCKISFDGPRCDIFKPIEYAAKFNGKAFIVFSPEEFPHLTSEQIEVIELRIKTTHKYGVLLWQSSTYTSSEYPTDYISLGINDGYLVFSYELGGGAARITSRDIVSDGEEHYIKIVRKGRSGNIYIDNSPVVKGESSGILAMLNADSYIYLGGLPKPNEMSGGIHSENFVGCIAELYFNSNKIGLMENAIDGQNVLPCSEWPSPYVRKRWFKNRKYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQT8</accession>
    <name>A0A0N5BQT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3Beta_HSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQT8"/>
    <dbReference type="WBParaSite" id="SPAL_0000825000.1">
        <property type="protein sequence ID" value="SPAL_0000825000.1"/>
        <property type="gene ID" value="SPAL_0000825000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF55">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000825000.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41678" checksum="1E4D19E0AA01E48D" modified="2015-12-09" version="1">MENVKNVCIFGYNNFIGKRLESEIKESYPEINIKYWQLHKPSDENGNCKSIFWGINSISGAIQDCKLVYNIVDYKDWSIKPNIEKLKFYNETIPQTLVDECKDVEGISIVHLSSALSQSSSVWPTLQEKEKKIEELKLDSVPFKSYVTSKVNGEKEILKYSQSIPMIIVRSPPCYGEGDTSSIVTDSIKILKKYGYLPGMSRDNGSFEMCYVGNVVDAMITCGETLLQGNMVGEVIIVGDDTPTKNIRESVVDQVLKDGKEEIPSSSLLLTGLPFVVFYYLFVWFIRLLGLSNFFRMLPDYNYFVMYYRNWCVFDKYKLKYVVGWKPKYSKEEAFRRSSNYYNGLFSDKDLHFSWKPHKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRX3</accession>
    <name>A0A0N5BRX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRX3"/>
    <dbReference type="STRING" id="174720.A0A0N5BRX3"/>
    <dbReference type="WBParaSite" id="SPAL_0000861800.1">
        <property type="protein sequence ID" value="SPAL_0000861800.1"/>
        <property type="gene ID" value="SPAL_0000861800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF6">
        <property type="entry name" value="PHOSPHOLIPID_GLYCEROL ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="235"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000861800.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="52367" checksum="283BE8BA30287731" modified="2015-12-09" version="1">MIFFQGSFLGVIYDYLLLIFICYITRVITIAASIDFSYLNEVYFYIIDCIHDFLEADCPQTNFDIDPKKFTNIIDTRKYFKLICSKKEEKQTFLNNLVLKEDKEKDHFVFDTGNNLLISGIEAIIEDDVVTLLEHHPEYQRFQSPFNPDNLKGPLQKIIAYTIIIYKFTFLLPIRVLFITTAILSFIASWAYGNYRKLTTFELKWIGKFGCSLMLASVGSYVKFHNRENKPFAPGFIAANHMSFTDVFPLYTDVDLDDKNVLQVTGQKGKGLVKMFQQVVSSILPTHWLNRHMTSERRRFLEKILREAKTQALILIFPEGYCSNNRSVLQFRKSIFVDNVNIYPVVFKQNSKYNDIFWYEDIFGHLMLRQLTSLGVIYEVYYLPKVTKQANENEAGFAYRVSEIISSKLGTTPSLWGGEHIYKKDNKEKVKDDIRRAILFACKCKYNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS45</accession>
    <name>A0A0N5BS45_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000869100.1">
        <property type="protein sequence ID" value="SPAL_0000869100.1"/>
        <property type="gene ID" value="SPAL_0000869100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000869100.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19443" checksum="F07E0F27A89AD85D" modified="2015-12-09" version="1">MXGCDFNCFARNNFQLLKEGLVEEINEYRRIHGVSPLTTYSVLEEGARAQARKNNLNVPTWFKKSSSVGYLGAICKLDDANFVVKEMYDKLLSNYNWNGKDPKNYATKLSQLIWKGTERIGVGVNVKSSRICIILFFSPKGGVGSFKKNVFPVAKRHIHMFHLFANRKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS82</accession>
    <name>A0A0N5BS82_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS82"/>
    <dbReference type="STRING" id="174720.A0A0N5BS82"/>
    <dbReference type="WBParaSite" id="SPAL_0000872700.1">
        <property type="protein sequence ID" value="SPAL_0000872700.1"/>
        <property type="gene ID" value="SPAL_0000872700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000872700.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39812" checksum="948030151B8E1561" modified="2015-12-09" version="1">MFIVRNYFYYHLVLFIFFNEGNCRAFVNRSVNNTIDEVFNKVENILFNDVTIFCLILTGPQYRKSRASYQKKTWIRGCNSYMYISSVRDPTLPSIALRVKEGKNNLWGKIKYGLRYVFHYYYRKPFDWFMLADDDTYVSMTNLRFLLITKNTSLPFHHGYKVKWNHSDGRTVKYVHGGGGDVLSREAFKRLVRYSLNNPKKCNRRSNGAGDFELSYCLTNVGVHVSDGRDFIKRPRFNPTNPLMNLASTYNHKFDKTMFRLSEGRAKHGIRHMPDYPISYHYLPGEMMLAIHYLLNIVNVVGKMNSLSRRLTTINCSKQTFLNESLNYLHSEANDAYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSG1</accession>
    <name>A0A0N5BSG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 102B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSG1"/>
    <dbReference type="STRING" id="174720.A0A0N5BSG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000880400.1">
        <property type="protein sequence ID" value="SPAL_0000880400.1"/>
        <property type="gene ID" value="SPAL_0000880400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000880400.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="16363" checksum="EE395D5F119E16D4" modified="2015-12-09" version="1">MERQKPNIHNRYDNTDITDKQISDNDAFFSKTIGRCQHTDWDVCENVRLQELKEIRERSAQMEKTMRWWSDCTASWREKWKTVKKEKNEAREEVEQLKKQLESMIYLYEQEKEKNKQLEEKIFELEKISQKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTP4</accession>
    <name>A0A0N5BTP4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="4">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTP4"/>
    <dbReference type="STRING" id="174720.A0A0N5BTP4"/>
    <dbReference type="WBParaSite" id="SPAL_0000922100.1">
        <property type="protein sequence ID" value="SPAL_0000922100.1"/>
        <property type="gene ID" value="SPAL_0000922100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF20">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="19">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000922100.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23421" checksum="4A2D74473C02D1E7" modified="2015-12-09" version="1">MVLAAFSAIFQRDVKAIAAYSSITHMSFVLCTLLFISMSGKTASVLIIVAHGYTSTLMFYLIGEFYRVARTRMVYYFNRFINSSLFFSIAFAVCILTNCGTPPRLGFIAEFITFRNIEIIRLLLFIIICLLLIIFFIIQAIAFSTLYERHLLGGAQGRIGPTKVTFIAALQAVLDGVKLLKKEQIIPVHASPLLFLLVPGLRFGVIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTR3</accession>
    <name>A0A0N5BTR3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HYPK_UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTR3"/>
    <dbReference type="WBParaSite" id="SPAL_0000924000.1">
        <property type="protein sequence ID" value="SPAL_0000924000.1"/>
        <property type="gene ID" value="SPAL_0000924000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000924000.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14362" checksum="21ADDB86DC01E5A5" modified="2015-12-09" version="1">DSGSHGKKEDDDNSEETEEDKQSLEITRQTIQILSEIDAVVNPEKNDEINSNVRTINTSHKRKSNIYNSSLYQGDIMLAPNDALELIEEAEKVAREKNVDITSINAKIKTFAENLKLNLKGTSSENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU04</accession>
    <name>A0A0N5BU04_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle 14 kDa protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU04"/>
    <dbReference type="WBParaSite" id="SPAL_0000932850.1">
        <property type="protein sequence ID" value="SPAL_0000932850.1"/>
        <property type="gene ID" value="SPAL_0000932850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000932850.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14716" checksum="BEA7C62A2AC9ADDA" modified="2015-12-09" version="1">MWAVPIVVTDILSFKTTQQMVESEKSQESFQIKYVIWSPRLEEVRYFKKGKNDSNYEMSDKLPGKGILRNKKIFDENGEDKTTTNTYLASQYTKTKMEELRNERPLSKKQMRKLKKRERNKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU80</accession>
    <name>A0A0N5BU80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU80"/>
    <dbReference type="WBParaSite" id="SPAL_0000939900.1">
        <property type="protein sequence ID" value="SPAL_0000939900.1"/>
        <property type="gene ID" value="SPAL_0000939900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895015" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000939900.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="7846" checksum="704426A892CF3A60" modified="2015-12-09" version="1">MLIITFVFAIILLCSPVYSRPGYGRPMPEPMPMSGGYGGNSYGGSSYGGSSYGGGMGGGMPMGGGGFGGGSFGGGGFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVD5</accession>
    <name>A0A0N5BVD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000979800.1">
        <property type="protein sequence ID" value="SPAL_0000979800.1"/>
        <property type="gene ID" value="SPAL_0000979800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895054" evidence="2">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="111"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000979800.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28943" checksum="6DF89D1458B6E99A" modified="2015-12-09" version="1">MIIFCSNYFTTFIILSILFVQYQALDEGEGSGDNESLNLIKRDDSSINLAKREAIIGSIVEISETENLKKRAAKKSEKSTKKVSKEKAKKKTTKKPSSKKPKKKKPSKYDKMKNKIINTINTIRKKYQAQKLTVDKTLATVAQNYVDRYAGKSVKESDVKLSKNTSVGTLVYRNKYNHPYIPFAVWTLGAPFIDFSNPERFPAGLEFTQLIWASTKKIGCGISYRSASKEVITMCLLSPKGNIEGKFKKNVLKPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW86</accession>
    <name>A0A0N5BW86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRESAN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW86"/>
    <dbReference type="WBParaSite" id="SPAL_0001008900.1">
        <property type="protein sequence ID" value="SPAL_0001008900.1"/>
        <property type="gene ID" value="SPAL_0001008900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001008900.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="39596" checksum="39936B3EE13F92B7" modified="2015-12-09" version="1">MVFTDNLQSNTSLPVLSSEFCTDSFNTININNKKVRKEDEYIEVDFVLNIHNIENIVSNLKKYDIFDNDTLHEYITMFINLMKSLKSQKKVETKSISDTNLERRSKKVGTFLYIKDELIHCVTNNNTLSDNKKKLLSWSILKKKLLKNEMNEDGNQLTFNKLGSYKEVFKSYSDLSISSLDIDKKEKLLKCWPSDYHSLLLYVKGEMKILFDINKDYNELLRIIKIFKSKKESHKKNANAYKILIPLSIKNQYFGTSYKKAQLSLVYDKLGFSQQTTENIKNFIKYDKLTENTRYHLSKLELLFHQYELRIIRLFIKLNVMQKELLESRSKIHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWI8</accession>
    <name>A0A0N5BWI8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fas apoptotic inhibitory molecule 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWI8"/>
    <dbReference type="STRING" id="174720.A0A0N5BWI8"/>
    <dbReference type="WBParaSite" id="SPAL_0001018200.1">
        <property type="protein sequence ID" value="SPAL_0001018200.1"/>
        <property type="gene ID" value="SPAL_0001018200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010695">
        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088:SF3">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE FAIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001018200.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21398" checksum="56ADB0A1BA77770C" modified="2015-12-09" version="1">MDSEGSDLVATWNVPMSKKVYKIEFEHGTTTGRRVVRVDGEVIINKNWQFKLVGKETFRLENSICSISIDALGIFSYEYSLEVAGKTFEKFQEQQKKSLVTWYAYIVGIPARICLDKDSMEVWINGKKIETAGIFVDDGTETHFVFNNTDCYIKNCSSGKKKIGVIHKLFVNGKEINEDDKIDEICNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWN4</accession>
    <name>A0A0N5BWN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWN4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWN4"/>
    <dbReference type="WBParaSite" id="SPAL_0001022700.1">
        <property type="protein sequence ID" value="SPAL_0001022700.1"/>
        <property type="gene ID" value="SPAL_0001022700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895048" evidence="2">
        <location>
            <begin position="20"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001022700.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="77397" checksum="A35A7E6AB4ED642C" modified="2015-12-09" version="1">MNFINYLYLIFIFFNVVIAQPNVDFFTTGFHGYDNRQLPTNLVSTYNTYTTNQNPNIYSETREYDFNKLFQSSSFNAVPSSASSYYSSGAQGNDKNSFVKTNSVNDLPPINTANLAGQDPNVLAQYLKYVESVQNIGGDNSGQLKNQNSYSSSILNGNSQNHNTEQPLNTYLSSQQTSASSFQTPYTLPSTGYSVSSQSNVNYPSSTLTSSNPYPGQVKTQYVSPSSGQPSSDFSKNVKTSYNIEYPAQPVYTGYPTNKVSGISSPSIYSGQEVSGHNTISSSSQYQNSINSPYTISQGYVNQPSVASSSYSQLPSNPQKPYETPNTINPYSNQVSQKTSLYTNNGQYNVNSDVNSYSSSNVPIISPPAPKTYTYVPPQKPTAAPQVQITPAPVYPANNYNSNPSNYNVPASSSSTSYNYQNIGVRQNNNVQPVIYPNNPAFNGVSSSNTQQVNNVYSQSVKQPTQNIVYTTQSPIKIETTTTLKETNSYIMESNLNPEYSNNVVTNYVKSTEKEDNFYVPDDQKSIYENIEEDNYEKTNSLPSQGISYKNSSEVEEDNNDITSQTSIAALTQQIKRLPAVFYADSRDPNTQRIEHMLRDTYGLPLVTFYLDKIDDTNTVEKNLQTLTAHTGTPYLFICGTFIGSQQHIDNYKDNKQIPQLVEYVCGDQKHRHRSKRHDNTISFPKVMWTLDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWT8</accession>
    <name>A0A0N5BWT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide_cyc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWT8"/>
    <dbReference type="STRING" id="174720.A0A0N5BWT8"/>
    <dbReference type="WBParaSite" id="SPAL_0001027800.1">
        <property type="protein sequence ID" value="SPAL_0001027800.1"/>
        <property type="gene ID" value="SPAL_0001027800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001027800.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21406" checksum="03E6A131EEA074EA" modified="2015-12-09" version="1">MSICTLHNIRRCLFSLPSTNKTQAYAEKRIIGFSANQMYNVVNDVGQYSEFVPWCKKSEANKISDSLTLCDLTIGFPPLREKYRSRVTSLSPFVVHSVCADGSLFEVLDTTWRFGPGLSTDLDHTCTLFFSLTFQFKYSIHAQISHLFFDQVVKTMVKAFLKRAEQLYGPPSFNHFDSKVEIIDYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX11</accession>
    <name>A0A0N5BX11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanylate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX11"/>
    <dbReference type="STRING" id="174720.A0A0N5BX11"/>
    <dbReference type="WBParaSite" id="SPAL_0001034800.1">
        <property type="protein sequence ID" value="SPAL_0001034800.1"/>
        <property type="gene ID" value="SPAL_0001034800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="267"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001034800.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53342" checksum="F28BD55FD1952BB1" modified="2015-12-09" version="1">MSENDNNELERLRMNAENLSHCLHSLMSRIRDLETKNGDPPMKIGNNETDSSDCQVCSNETITTDEKSGLKKKIIVTERILTTKTFHSQPLNLSINNNLMNKLNDTSSEEITCENKFPIACNNEYLDNCNEKRIVKIPGNIAHKLDLEFVGGKYINKNDNLNLNTNINVGDVIEAIDNKQLTNRNQLLGYNDNLNLTVRSSKIGEGNTTFFKIMENSCCSNIGDICEVLDKNEDTFVVRNINNLNNIFTLPRSILHLNVSLIAPFPRRTICLVGSKSVGKNSVKQLLLKQYGHLFSTVVPYTSRERKNGEIEGVHYNYVTKEELQSRIRNDDLFEFGEFEHELYGSSKSDVRRLIRSGKIVILDITINGVKNLFNREFMPFVICIRAPPYQELVELHNKVYNTNKTDIEIKEIHNNSEKFYKYNKSSLFDITIVNRNHDLTVQRILLALDNLKNQSQWTPTSWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXG0</accession>
    <name>A0A0N5BXG0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXG0"/>
    <dbReference type="WBParaSite" id="SPAL_0001048950.1">
        <property type="protein sequence ID" value="SPAL_0001048950.1"/>
        <property type="gene ID" value="SPAL_0001048950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001048950.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12093" checksum="95BEF49BEE10CB2E" modified="2015-12-09" version="1">MKSLYAWTLLKNILLEVMKGKYHCKFRNTFICVFVRFLVDVLYHNQIIPHVNFPQADKKGHELICLQEFKYCLDYSFIEITFLKEIIIITMIDIQTSPKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXT5</accession>
    <name>A0A0N5BXT5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRRNT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXT5"/>
    <dbReference type="WBParaSite" id="SPAL_0001060300.1">
        <property type="protein sequence ID" value="SPAL_0001060300.1"/>
        <property type="gene ID" value="SPAL_0001060300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895010" evidence="1">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001060300.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22383" checksum="51A92707FCCC0BB3" modified="2015-12-09" version="1">MNFCLLLIFIFLNTIYGAIFKCLDNCECDDSEGVIHCHELKLTFLNLPKKPMENYRVLRLTDNNLEYLPSEEMLKSKFPQLTGVDVEGNSNFDCDSIKYYKRLTIFSDCTDKGIIESKKVTTTSSTTDASGDDDCDIQCKISNKAQEFANYAKRYWKKFVEKLEQFDRENKTWIEIKGVFKSFKNTLADVFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ58</accession>
    <name>A0A0N5BZ58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ58"/>
    <dbReference type="WBParaSite" id="SPAL_0001105300.1">
        <property type="protein sequence ID" value="SPAL_0001105300.1"/>
        <property type="gene ID" value="SPAL_0001105300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF11">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001105300.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54542" checksum="8461D052161CC98D" modified="2015-12-09" version="1">MDIKINIEPWITVVIGLLYLIFGFIGFVSNFTTFLMICFKRVYRLSAYTIMANIALADSVIMLLIGGGCGFYILYLDRKNIGLNKPSNSSMQATNEIYLLSYNLNKLNTIICFLLISAWISGILSYAILGMNRCVAIRYYGTKAKFFNRVSIAIISSILAWLIGTITAYFGTFPEPIIGLRSELWSITFKENVNNKRSKLYFYIIAFLNIISLSIQWICSILVLLRIRVVKEKINKNKLNQSSANRFKKQARLTFQFFYPSLLCTISSILFLSKPFLFGIFSNWHLIILHLIWIFNHLCNPFIYSYFNERMRFTYREIYHCSYIQYLVQKRRRFSTMGWTRRSHRYIGKSARNSVKSCRSTRDGNFVRNSLQMQSRDFEQLCEFMMRVNPLYDSSEGWQECSDEEESFNKRPIIKCTKKKKNKNDICKKEDQKELSNTGIESRSVVLHLGRDTVEQWVRFAKKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZQ3</accession>
    <name>A0A0N5BZQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001124400.1">
        <property type="protein sequence ID" value="SPAL_0001124400.1"/>
        <property type="gene ID" value="SPAL_0001124400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001124400.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9658" checksum="9A24D834F00B13AE" modified="2015-12-09" version="1">MFDFLAHFQNIQTHTILLITFCCIIFYAEAVTIVGAVDSETLLLLFASVLLSSVFDASFFISFSEDGSVQSYKNSCLIYVKKMNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZU1</accession>
    <name>A0A0N5BZU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutenin, low molecular weight subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZU1"/>
    <dbReference type="WBParaSite" id="SPAL_0001128100.1">
        <property type="protein sequence ID" value="SPAL_0001128100.1"/>
        <property type="gene ID" value="SPAL_0001128100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001128100.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="20578" checksum="AA6082269D13DF65" modified="2015-12-09" version="1">MCGGPKKKNPQTGRKGLNSAKSLPQAGNSFEGQKTGGSRPPPSGYNPAIPGPTPSKMGQGPPTPSMMQKQQQNFLNSPAGTPQPFGQPQDGFGQPPQQGFGQPQGFGQPQQGFGQPQGFGQPQQGFGQQPQGFGQPQQGFGQPQQGFGQQPQGFGMGVGSAYVPMNPMYPTVGAAVVTPGVGVGLGGGLFGGGIYGAGYPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Q4</accession>
    <name>A0A0N5C0Q4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Q4"/>
    <dbReference type="WBParaSite" id="SPAL_0001158200.1">
        <property type="protein sequence ID" value="SPAL_0001158200.1"/>
        <property type="gene ID" value="SPAL_0001158200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895154" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001158200.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14452" checksum="5C72C3DB8D1CF4F0" modified="2015-12-09" version="1">MKFLVLLCYLFLLVIKLKCYESVKTLIDADDQNKTPCSKGCYGMCFNKEYSRIQRKQCCNHKYCGCCDSSFHISKHSPLDEIHINSDKLVTDGNGQILEGYYVKTLSKDLVENSIEELNIIHSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Q5</accession>
    <name>A0A0N5C0Q5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZnMc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Q5"/>
    <dbReference type="WBParaSite" id="SPAL_0001158300.1">
        <property type="protein sequence ID" value="SPAL_0001158300.1"/>
        <property type="gene ID" value="SPAL_0001158300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001158300.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42087" checksum="50C1CA22030AB43D" modified="2015-12-09" version="1">MPLQVNDKSLDFLLDRTKRGIFKNSKYFLGKMPIKYSTTAPINESNLNKALKLIEQDTCIKFKKEEVIPETSQGFMYYVNPANFTFCGPQFPDKPQVVFLSKECNNNVGCHLRQTVLSLGLLRQFNRPDRDDFIKINVSNAYWYVYGGEILETTFSKDEIDLYNTSYDFGSITHLDPYEYINNSKPVMESIIPEYNNMMGQNYRLSFNDAKLLNLALCKSTCKGNKLFCNNNGYPDPKKCHCRCPNGYTGKYCQYIKELGKKCGNKKLVAKKSKQILKNSGEGSCNYLITSEKGTKIALTLISSNTTKIIPCFQKMGVEIKYRSDKGTTGLCLCGEFKNIALKSDDNTVLIQYNGKNDNDQFKLSYKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C142</accession>
    <name>A0A0N5C142_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C142"/>
    <dbReference type="WBParaSite" id="SPAL_0001172100.1">
        <property type="protein sequence ID" value="SPAL_0001172100.1"/>
        <property type="gene ID" value="SPAL_0001172100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001172100.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="37901" checksum="FD7CB21597370989" modified="2015-12-09" version="1">MIIKNYLYLLLLYILSIGILVTSLSNYTREIINCERDAKSKPCIPPYRNVLSRFRVNKKYKMNFCTITKNFSTMIRGILCFLDHPGYAKKYQTPISNTKWTYKYCDDYNFEEKTVDIAKNYTDGSVNKLMKSYTNIVFVREPIERFISGFVDKCLIAKDFIKIDPTYCYGCKTNLKCFVNRFYKRIKEQILFPKRKHTDTFDDTHFYPQTWHCQLNIYRQYYTIIKYGTTTESSKIFYKEFFELLKSKKIPQKQINFIKNGTINKHTPHSTSNKKITSRITNVIKNSPQILEKLIRIFYYDFIEFDYPIPDLPEPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2G0</accession>
    <name>A0A0N5C2G0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2G0"/>
    <dbReference type="STRING" id="174720.A0A0N5C2G0"/>
    <dbReference type="WBParaSite" id="SPAL_0001217000.1">
        <property type="protein sequence ID" value="SPAL_0001217000.1"/>
        <property type="gene ID" value="SPAL_0001217000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001217000.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="56149" checksum="598F14BDE6626C04" modified="2015-12-09" version="1">MQVPFIPNFYYISDEDLGSSNYDIYQSLFDGIPEDHPGYPPDCFLFVAAKLFNMNRADWERISSFCLNPNGLFDRHSFFVFLKIAAVQQANAEINEPNLKCDFPVTKYLDEDWKIPQDRLQIYQSIFDAKNKNDGKITKEDVYQTSKIRNFMIPKCCEDYFYLTDFDKDGYHDFPEFVAIMELIHKTLTMPNQDIQDNVQSYLISNTKVFPFKIIWDNLRNSGFNKETYETKLTAFVPGIRAIPIGDPTAEFQEKKMTLNCQNVELSRTAAQLKRDGDSYKILLNEQLQKIEEAVKRRDGVKLRANELKNQIRNLEQRQKDGKALIDEKKEHLENLKRSYDKQKEHLETEKVDLLRMRKITNNVVDYKNEMEQVIADLQQRKYELTNKLVSERDFLIQALNDHLKKKNSLYSNDRLLSLVDEFKIYKPYIDDRTAYMTACINALDNSQIPNIGKAFVRFQSTKDGIYEPASFPNSQDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2K8</accession>
    <name>A0A0N5C2K8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2K8"/>
    <dbReference type="WBParaSite" id="SPAL_0001221800.1">
        <property type="protein sequence ID" value="SPAL_0001221800.1"/>
        <property type="gene ID" value="SPAL_0001221800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895247" evidence="2">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001221800.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14921" checksum="3C098DB56DA0BB23" modified="2015-12-09" version="1">MNFLKYLIILGLFTIQYSVQSSASSEDSSSVSDTNESHENSPELLTEVEDKSDNNASTDLSNDTMSQEIEKTDSKKKSGVKRFFSDVGKKAKKIIKSDTTKKVGKGLVKGGMKLVEALMNSSDEEKKKKKKKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2S7</accession>
    <name>A0A0N5C2S7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP1_OBG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2S7"/>
    <dbReference type="STRING" id="174720.A0A0N5C2S7"/>
    <dbReference type="WBParaSite" id="SPAL_0001228700.1">
        <property type="protein sequence ID" value="SPAL_0001228700.1"/>
        <property type="gene ID" value="SPAL_0001228700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="1">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001228700.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12682" checksum="DE54B7CF97249513" modified="2015-12-09" version="1">MFSYSRNIRYLSTNLFLKKPVFPKKPKSEGDGKHFVDYRRVLCKSGNGGNGMISFFKGYRVPFGGPDGGDGGNGGHIIFKADKSTRDLSHLQSVIKAGNGEYGMGKNCHGKSAPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C361</accession>
    <name>A0A0N5C361_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C361"/>
    <dbReference type="WBParaSite" id="SPAL_0001241600.3">
        <property type="protein sequence ID" value="SPAL_0001241600.3"/>
        <property type="gene ID" value="SPAL_0001241600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF2">
        <property type="entry name" value="SIMILAR TO NOVEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001241600.3"/>
        </source>
    </evidence>
    <sequence length="186" mass="21548" checksum="2C484EA599E53D10" modified="2015-12-09" version="1">MNILRGKLCEVKQLVHTSLSMASGRWYPQPEIIVRNCSTDSVPEVSKKLQNLDKNKIAPCYVTSKKDDGNIPYELVPYKKDKNGRVTMRTSQRLFEDSLKKSEISYEVYEKLSKEERDIYMAHLKAIEDRALTYKDPKTGYIVMTVSQHLYKAKCCGNACRHCPYNQINATEEAKKSKKWNGAFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3R0</accession>
    <name>A0A0N5C3R0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3R0"/>
    <dbReference type="STRING" id="174720.A0A0N5C3R0"/>
    <dbReference type="WBParaSite" id="SPAL_0001260000.1">
        <property type="protein sequence ID" value="SPAL_0001260000.1"/>
        <property type="gene ID" value="SPAL_0001260000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="266"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001260000.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40237" checksum="6FD94482C261256E" modified="2015-12-09" version="1">MIVLSDNVIHLIGGGLGGALGATITCPLELIKVRLQSTTGIKGNSTKFNDVPGHSSKTSNAVKNNLSNGMTLPNFENCKNSEKNKFYKSFSNNNNKIRGQVKRFQILRVATAAREIMVNEGGWRSLYKGLIPLVSAVVPSKCIYFYTFHWALKNFNDSSIFIPNTVAAYMSASAVGGMSCLIVCNPIQVVRTRVQLSNGKMSVINCVVHTAKYEGIQGFYRGFVASSYGISESMITFAMYYKMKEKLHKFWENWEGFSVFGTNFSKDWCVHSVCGGTSKFVGVALTYPHEIVRTRTREMGTYKKIGFWHHIMEIYKEGGIRAMYKGIDVQMMRTVPNTAICLATYELVVKTLNQYYHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3S4</accession>
    <name>A0A0N5C3S4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3S4"/>
    <dbReference type="STRING" id="174720.A0A0N5C3S4"/>
    <dbReference type="WBParaSite" id="SPAL_0001261300.1">
        <property type="protein sequence ID" value="SPAL_0001261300.1"/>
        <property type="gene ID" value="SPAL_0001261300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="63"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001261300.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48573" checksum="FC48B69B49C37482" modified="2015-12-09" version="1">MNPTNIEESRNSHTESEELSQSEENNSTLLNPLNNTIPLQDNIRSFYDVVINETTTLRVPRRYQNITLIGSGAQGCVYSAFDSIQRIPVAIKKLSRPFLNSTHAKRAYREFCLLNMVHHRNIISLFNAFTPQTTYADFTDLYIVMEKMDATLQQVIQMQLDHERISYLLYQMLCGIKHLHAAGIIHRDLKPSNIVVNKHCVLKILDFGLARSAANANANMTPYVVTRYYRAPEVILGMPYQEIVDIWAIGCIFGELILGHVLFQGSDHIDQWTKIVAQLGTPDDTFIDKLQSSVASYVRQRPRIEGCKWEQLFPTSNFPADSIHTNLTAEHARDLLSRMLQIDPEKRITVDEALEHPYVRIWYDPVEVNTRPQGNYDESVDSEHSVEEWKTLIYEKIRQYQTENDIFTKLAPIQDDSANGAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3U0</accession>
    <name>A0A0N5C3U0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3U0"/>
    <dbReference type="STRING" id="174720.A0A0N5C3U0"/>
    <dbReference type="WBParaSite" id="SPAL_0001262600.1">
        <property type="protein sequence ID" value="SPAL_0001262600.1"/>
        <property type="gene ID" value="SPAL_0001262600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001262600.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23863" checksum="4695A5EF4E83ADE8" modified="2015-12-09" version="1">MVSTLDDTFDYLFKIVLIGDMGVGKTCVVQRFKSGTFIEQQGTTIGVDFTMKTMIVDGKKIKLQIWDTGGQERFRTITQSYYRSANGIILCYDMTCKQSYESLQRWIDDVVKYAVPNVSKILIATKADKEDERVVGYDEGLHLSSTHSMCGFFEVSSKSNVNIEKVFYKMAVRLKNQYESGLLLDEAGNSFSIKTNETSALPTTFNNCCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Y1</accession>
    <name>A0A0N5C3Y1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BppU_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0001266500.1">
        <property type="protein sequence ID" value="SPAL_0001266500.1"/>
        <property type="gene ID" value="SPAL_0001266500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001266500.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9067" checksum="776EBE76562ED9DE" modified="2015-12-09" version="1">MFSSIRNAQNIRKCVEHGETLHDITLSKEKLIDIPLGKFKEITSEINFKKWEVKGYIPDFNLVTFNIEGTKKASIFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C587</accession>
    <name>A0A0N5C587_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein VAC14 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C587"/>
    <dbReference type="STRING" id="174720.A0A0N5C587"/>
    <dbReference type="WBParaSite" id="SPAL_0001311400.1">
        <property type="protein sequence ID" value="SPAL_0001311400.1"/>
        <property type="gene ID" value="SPAL_0001311400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="8">
        <location>
            <begin position="453"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001311400.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="78306" checksum="20993A87886E9344" modified="2015-12-09" version="1">MSDSQYAPLTASLVKALTDKLFEKRKLAATDLEKQVREIVKNEQTKDLERVILILCSLTTNPNMHARAGGLIGIAAVAIALGKNSLPYTRTLIEAVMPSFMDHESKVRYYACESLYNVVKICKGNSLNMFDQLFDTLWRLSADTDQNVRSGADLLERLLKDIVKTTEGFNVEKVMVLIKERIYAEEFYCRRFIISWLKHMIDIPGFDIVVYIPELLDGLFKMLGDNMDVVRTFTENVLNQLLMKINKDNVGNINIKGIIDILVVHTKSSSNNVVGKRVALVWLEKLVTVSNIQLIFPHLPNYLTAVLPCLTTNETKASVINKKLMELNLIGSTLPIKEIVDVLLFYMSYENIETRVASLNWIQKLYSAVPSELFLFMDQLFPKLLSSLTDSSDEVLILAIDILAEVCGEKSVKIDDKELNIKDELTEELCYVSPYLLKFTTSLLDMFRKEPSLMNDRGVAIIRQTCALLGPDHIYKSFALLLVKDCDFDFISKMVSMLNMILNTTLECYDLREKLRKLETKEGVDLFLTIYRCWCYQPINVLGLCLLSQNYIHAADIVQRLSRVDMTVDLLVEIDRLIQLIESPILSHVRLDLLSINHQKPLAAVLSSLLMLLPQTEAFNTLHKRLQLIPLLSTTENSNGQEIRKYGREINFQNLLHHFDNTFVKRQNNIRAVHKNKLRQNLSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5G4</accession>
    <name>A0A0N5C5G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5G4"/>
    <dbReference type="WBParaSite" id="SPAL_0000928300.1">
        <property type="protein sequence ID" value="SPAL_0000928300.1"/>
        <property type="gene ID" value="SPAL_0000928300"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001319200.1">
        <property type="protein sequence ID" value="SPAL_0001319200.1"/>
        <property type="gene ID" value="SPAL_0001319200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009790773" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000928300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001319200.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8548" checksum="663DD45943BEFE3E" modified="2015-12-09" version="1">MKTIYIIFFLSFFIACGSYGSTPAVIEKNGLVGKCKKLKCKYKCMQEHKLGECNFSGTEGNPETRKAECICIAIPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5P4</accession>
    <name>A0A0N5C5P4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5P4"/>
    <dbReference type="WBParaSite" id="SPAL_0001327100.1">
        <property type="protein sequence ID" value="SPAL_0001327100.1"/>
        <property type="gene ID" value="SPAL_0001327100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001327100.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41652" checksum="EAEDE6B97ACA127E" modified="2015-12-09" version="1">MLLVNEVVEHKLDPQQKHNENEIHFPHDDETKALSITRYYEYLYGMLALSTKNNEEELLGTYFKFLSLVITNIYKRPEQEKERNEVLHRTAKQILLLLRFYRLANVNIRGNYDYEEYAIDIGTRVAYHKLRFSEIANSMIQEKYCFIPRFFTLTNENLRGEYLSQNRIIACCSICNNYDLNSFNVYFNVSMIPNFIKYSESLNTSQHIFGLLLGKQKEIGTVELCRILSFRENQDLFDPKNLKLVVNNIAARGYFIYGIICYNQSPSSLLKMPEIKYREYVNCGAFVINYFKHVGASLIYHFPRVDEEIWKPIIPNQPLLEYVVTHFTSCSHININHTVENGIIEHDRYIIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C611</accession>
    <name>A0A0N5C611_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C611"/>
    <dbReference type="STRING" id="174720.A0A0N5C611"/>
    <dbReference type="WBParaSite" id="SPAL_0001338700.1">
        <property type="protein sequence ID" value="SPAL_0001338700.1"/>
        <property type="gene ID" value="SPAL_0001338700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF130">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001338700.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="58791" checksum="AB4713D022B082EA" modified="2015-12-09" version="1">MIILPVIFTLLTLYIATNIKRIKTWWLERRRRIELAEKIPGPKALPIFGNSLSFMGTSGDIRKKLNEESAIAFKNNDPLRRYWIGDVLLIHGLSSEATKIIYDSTSEISKGRSYNFFSLWLGDGLLISDGDKWKGRRRLLTPTFHFNMLKRYFEAYNNESRLMVQRFEKFAKSGEEVEIFNIVKRMALDIICDTAMGVKINAIDEPNNPYLLAVEKYAKLGVIHFRSVFYKIPIIYYLFGDGFERDKTLSILKSFTQSIIKRKTLEFENNNGELHDNTFLSNLLQLKQENKWTDEDIREEVETFMFAGHDTTSSLVSFLWWALACHQDIQEKVYEEICDVFGEEERDVLPEDLPKLNYTDMVIKETLRRYSIVPYFNRAINNEIEVCGYVIPKGANFVFPLQHTNYNPKVFPDPYKFDPDRFLPENVAKRNAYDFTPFSAGPRNCIGQKFALNETKTMLIWILRRYKLTTKRNEDYVQSVPDIIQKPTTGIPIILVKRNIEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C650</accession>
    <name>A0A0N5C650_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C650"/>
    <dbReference type="WBParaSite" id="SPAL_0001342500.1">
        <property type="protein sequence ID" value="SPAL_0001342500.1"/>
        <property type="gene ID" value="SPAL_0001342500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001342500.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13771" checksum="E52ED5484FB50E57" modified="2015-12-09" version="1">MLSVVAINSVNVVFICEFENVIKLTLVLEVVSEDIVANCCETNVTKTVTIEGVVLLDVASNLFVDSVVVIIGCEDLGGFVLTLFFEAGGNISVSTVGFSLDVSKVLIKSDGGFICKNSFSAENVCVLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6A3</accession>
    <name>A0A0N5C6A3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CLD20 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6A3"/>
    <dbReference type="WBParaSite" id="SPAL_0001347400.1">
        <property type="protein sequence ID" value="SPAL_0001347400.1"/>
        <property type="gene ID" value="SPAL_0001347400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001347400.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14418" checksum="4496C8CEF00D4454" modified="2015-12-09" version="1">FDWYSFTNYAYFQIAVIIVPLCMGTFSLIAIASIKCCDCHWPRLRHSMIAGTGIIVYTLAGVLETLVCFNILDYYDFYGIKTYLIESKKIFVKGYLASAIFLFLSSFLAMVDACLLDARRFNIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6T5</accession>
    <name>A0A0N5C6T5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 30</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001365000.1">
        <property type="protein sequence ID" value="SPAL_0001365000.1"/>
        <property type="gene ID" value="SPAL_0001365000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001365000.1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3809" checksum="209F2DE0B844CA60" modified="2015-12-09" version="1">XLLAETAEPEMLQNRKEYCENQIYMFQFLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7G4</accession>
    <name>A0A0N5C7G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7G4"/>
    <dbReference type="WBParaSite" id="SPAL_0001387700.1">
        <property type="protein sequence ID" value="SPAL_0001387700.1"/>
        <property type="gene ID" value="SPAL_0001387700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001387700.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13124" checksum="6629670F1CE51931" modified="2015-12-09" version="1">MGTTMSSEPSSYKYYDKSIYTSKGSSKSPYSTQFSKEYWTRNKEDKLRNSTPSDRSAYQKMTYGEGKKDKFVSAFCDQPKTSISSSSSFSNNRIDRSPSNLFSSTSKSNQYYTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7G8</accession>
    <name>A0A0N5C7G8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Protein kinase C-like 3</fullName>
            <ecNumber evidence="3">2.7.11.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Atypical protein kinase C-3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interaction with par-3 required for the peripheral localization of par-6 and to form a par-3/par-6/pkc-3 complex, which is activated when cdc-42 interacts with par-6. Binds avidly to the phosphotyrosine interaction domain (PID) of a novel pkc-3 adapter protein num-1, which enables tethering and targeting of pkc-3 to the cell periphery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7G8"/>
    <dbReference type="STRING" id="174720.A0A0N5C7G8"/>
    <dbReference type="WBParaSite" id="SPAL_0001388100.1">
        <property type="protein sequence ID" value="SPAL_0001388100.1"/>
        <property type="gene ID" value="SPAL_0001388100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007506">
        <property type="term" value="P:gonadal mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000071">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012233">
        <property type="entry name" value="PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000554">
        <property type="entry name" value="PKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 24 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-0278">Fertilization</keyword>
    <keyword evidence="15" id="KW-0306">Gastrulation</keyword>
    <keyword evidence="13" id="KW-0334">Gonadal differentiation</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 24 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="29">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="27">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="281"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="28">
        <location>
            <begin position="553"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="23">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="287"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001388100.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="71781" checksum="14A040041613DFE7" modified="2015-12-09" version="1">MVNIESEEDIKVKVRFLSDVVILYTRSTLTYDTFVRLIRDACKIPNDEKCTIKWIDEEGDPCTISSPPEMEEAFRLTRETRDAELCIHVFKGCPAVPGLPCQGEDKYVYRRGARRWNKIYQVNGHRFHIKRLKSNTPCFICSGSIWGITGQGYRCMDCRLCVHKKCHRNVRRICDANLPPTKTEQEQKQAITEHAFIKEYKNNFKNDVNNGKVIKNYQSVGGISSGIENMAFDSNNQDIYMKGIPKVNDSSQLRGSLKEVNAVEQTMKVSGVSKKVTLDDFNLLTVIGRGSYAKVVQAEHKKTKDIYAIKIIKKQMFNDDEDIDWVQTEKTVFETASNHPFLVGLHSCFQTDSRLFFVIEFVPGGDLMYHMQRHRKLPEDHARFYSAEIILALHFLHTSGIIYRDLKLDNVLIDSTGHIKLTDYGMCKENIGPGDRTNTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMYEMMAGRSPFDVVAMNGDTDQNSEDYLFEIILEKQIRIPRSLSVKAAGILRGFLNKFPDDRLGCNPDLVVALNDMKNNAFFKNHIDWEMLEAKQIQPPYNPNVQSDRDLQHFDKQFTDEAPNLTIDDPNVIARIDQTEFEGFEYVNPLLMAKEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7X4</accession>
    <name>A0A0N5C7X4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7X4"/>
    <dbReference type="WBParaSite" id="SPAL_0001403500.1">
        <property type="protein sequence ID" value="SPAL_0001403500.1"/>
        <property type="gene ID" value="SPAL_0001403500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001403500.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7482" checksum="ADA1EB463DBE790C" modified="2015-12-09" version="1">WINIVKFTANMSFKIQDVDGDRNSWSRLLSPSLSYSLPSFLHGQAGDTTGTVNHKDKFKEIQLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8B2</accession>
    <name>A0A0N5C8B2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C8B2"/>
    <dbReference type="WBParaSite" id="SPAL_0001416300.2">
        <property type="protein sequence ID" value="SPAL_0001416300.2"/>
        <property type="gene ID" value="SPAL_0001416300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001384">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4178"/>
            <end position="4368"/>
        </location>
    </feature>
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        <location>
            <begin position="3597"/>
            <end position="3997"/>
        </location>
    </feature>
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        <location>
            <begin position="3599"/>
            <end position="3612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3644"/>
            <end position="3664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
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            <end position="3687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3688"/>
            <end position="3706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3736"/>
            <end position="3764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="3765"/>
            <end position="3777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="3800"/>
            <end position="3819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="3835"/>
            <end position="3850"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3864"/>
            <end position="3873"/>
        </location>
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            <begin position="3874"/>
            <end position="3890"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3891"/>
            <end position="3905"/>
        </location>
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            <begin position="3906"/>
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        <location>
            <begin position="3921"/>
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        <location>
            <begin position="3974"/>
            <end position="3986"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001416300.2"/>
        </source>
    </evidence>
    <sequence length="4377" mass="502656" checksum="AFA7B966DB29AF63" modified="2015-12-09" version="1">[encoded data, 4377 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8R5</accession>
    <name>A0A0N5C8R5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="SPAL_0001430600"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
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            <begin position="269"/>
            <end position="381"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="214"/>
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            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
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            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001430600.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46948" checksum="5158F1FE5B4A85D5" modified="2015-12-09" version="1">MNGRRGDEENSCSLLFNSSNITVRRSTNKNNSSHGISSNKSPQLLTHLDNSSITPHSNGSINKFLEGLSNMATTSTLMRKQAETQMKAVNCMTKWAVENDNAAIEDVMKKTNEVFKIFSDRLVRFSSEHETSVKVLKKIEQTEKAIKIAEKKLSQINEQEKKIEKDIKKYSRSSSSSFFKSKKPTDLAILHHDLNNIKNAKAVAKKELSDIQAEMEVIKMFRFRKGMEGISVAWRNLAMDLASIFTCQQELIDMVPAVSTEDVREMVYEGSSQTKSMIEDLKDKLRMTNPSNNDERISGRRSEPVRSRPQLLGECIRRGTPPPPYSLAIAPEHETPTPRRHSAFISPTSSIDSDYSSSSNTSSNNGLSERTPLRIPISPDGQIPNGRLYPILSPNPYKENIGNRNGGRLSIYSNHVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C932</accession>
    <name>A0A0N5C932_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C932"/>
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        <property type="protein sequence ID" value="SPAL_0001441500.1"/>
        <property type="gene ID" value="SPAL_0001441500"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895567" evidence="3">
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            <begin position="19"/>
            <end position="1108"/>
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    </feature>
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        <location>
            <begin position="905"/>
            <end position="929"/>
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            <begin position="956"/>
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        </location>
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            <begin position="962"/>
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            <end position="984"/>
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            <end position="1030"/>
        </location>
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            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
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        <location>
            <begin position="1071"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001441500.1"/>
        </source>
    </evidence>
    <sequence length="1108" mass="126570" checksum="C030854719E53D92" modified="2015-12-09" version="1">MFFKILNILSTIFLLSNCVVENFTDYTSNAILQRSFKYKLDIKFEIPKTSFITVEPDAKLFFYPAYEVNHGVNKSSIRWIGLPCTYESTSIFKDITGTENVKGSFSCNVNDDEKYFNGIFYSKQCLESLHPDCYPKPNVFLLNINDHKYNTIKFNRIKCRIQYINHYKGTGEVNTFIAHGNSLETKFTKTEGQENRKPTILRLITTSSIIETYNKHSPAGISCNYDETNKKVNCNNSNITDPNESDKFLKFHQYNQTYENNIDVKYGLEIPKNDEEEIEYELTLDFQKNPSDNSSLLGEVFFVTVDKEGKHSIKMFGGIIEFKKSGEKILLKTKKLHYISNECLRLRIEEEKNNDQHFTKSCIPFPNLVKITFLQHNSDISKKISLNVFSLTVLSNVTNPSTGKKETYTWKGTYADNKVNYYKSYTFNKNVFTISMREDILDSEEIGDGATEKHVDYTLNSYIQKGVGYNVDVDIKLTLSSITSAINFFPAFSRKILKGDKVNNFLTWIGKPCTMTNTDKTSIPKNRNPNDIVSKQVKCTVEDAFEISKDEDKFNGMFYEPVCLKKLHKDCWMNTLHLLINFGNNNSINDYIYITSLNYSFTAFDLLNGKVITTYIGHKNWELNAKHGIKKHSKIGILRLYTGKNFISDPSKEELNCVYSRGDQRSSCNNGEVIEKESIMEKVGFQNLLVSNNDIQIYGYNKKHKTINYKYNNYYEVTFEFSKITQSTCKVFMEIFIVNFNESGKIMLELYGGIIELDQEKYFNKKGIIYLKTNQLNFVDKNCTNNNDCPPIGNAIKVTFMIGNNEKCDNLSLKYVKILTLLKGNLKNLNNAKTEHEIAFQDSQSIEFAKTYAIYTSNRNTSVILNVNRTWNFNSQNEELILVDPVDLKKIDKLETCPKSHIYSIIFYICLSIGLIETVVLIVVILLIIRGCKKSENGDDDDFDIQEKRSAKAKNEVADINIVDEENPSDGEEQKDVNKEEGKQHGNYNKSNYKELQGGEKAAYNEGGNYNNEERDGECEDDNNDGVDDNEGGKDKKQTKGKKQAPTKGVKKAGNKKTSQQKKTTPGGKKAASKIKGKKAAGGKKGTPRKVPPKGKVKPRPAPRGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9D4</accession>
    <name>A0A0N5C9D4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001451800.1">
        <property type="protein sequence ID" value="SPAL_0001451800.1"/>
        <property type="gene ID" value="SPAL_0001451800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001451800.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32043" checksum="AC298969723B8A34" modified="2015-12-09" version="1">MHLFFLINTNPFLDIPTPKTPKMIEISGIGIPKPKPLCKEFNEILNRRNKTILLSFGSVAKSTYIDQEMKDEILRTIQSFPDITFIWKYETPEDGHGSGIENLVLSKWVPQNDLLNDERLTLFITHGGMGSTTEAAFSKVPALAIPLFGDQRRNGKLLERLEIGLAIEKEILRDSKKLSKKIFEVLNNKKYKINSIITAEMLQNRPISSEELLLKHVEFACKYGQLPRLDLGSKNMGVIEYYNLDITIPFISACFLLIYILIKIISKVGSKYFFKKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Y5</accession>
    <name>A0A0N5C9Y5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Y5"/>
    <dbReference type="WBParaSite" id="SPAL_0001471200.1">
        <property type="protein sequence ID" value="SPAL_0001471200.1"/>
        <property type="gene ID" value="SPAL_0001471200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057233">
        <property type="entry name" value="DUF7911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25492">
        <property type="entry name" value="DUF7911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001471200.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="67584" checksum="44C9C26F821ECB9D" modified="2015-12-09" version="1">MNIIKYISLNSFYSLILYILWFNLLTISNTVTLGKGKACREENIYQYSKNYSTPDLIFYGLTSDCQIFFSTLLNIDKIHDLKVDHKHQHCSPHYTKLHLVNYLGQLSILVTTLRHGNNFCTMNIEFPAIEFITSPFLFTYSLMSSLPFFACSSLPLHSGFLLQPSQSYIDPRVSDVIHFVGKNSTSKEIIELQFKITPEGYLVRHKQTRATNIFGKRQQRVLVTVDRRTGLLYSIGDTESMNLLGTCSLDPHTLPFGKNHLESNIYSLADKYSKVDSLSVDEKTIMLGIQKSRDVQKTRLLIGHLKERINFKCFISLPYLAQVSMVSKRTIDKLNEGQILTLEMELKEKQKELELKMVKEKFSHLNNTVKIGGPEERERKNNHSDNKNIIIESNDIKVPLTTIFPIPITITTTDSVKTQETIINNQEKENNKINLGKKEEDEDLTSKMEEELNNKIKLLENTNDEVKDLFKEEENNKEELTEFDSTNETVPNEGKIEYFDIDNSVKEPHDLPTDGPNIFDGSITSDDNSDNNNHNYPKLKDSLIPTTSKNNASLISNNSSPSNLMGVVKNHFISFFITFPLISLTLHSTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAB3</accession>
    <name>A0A0N5CAB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001483600.1">
        <property type="protein sequence ID" value="SPAL_0001483600.1"/>
        <property type="gene ID" value="SPAL_0001483600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001483600.1"/>
        </source>
    </evidence>
    <sequence length="29" mass="3278" checksum="2CBBE05833FD93C1" modified="2015-12-09" version="1">XEPKFRGERLSQQLFDEPVCVSISASKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBK5</accession>
    <name>A0A0N5CBK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBK5"/>
    <dbReference type="WBParaSite" id="SPAL_0001527100.1">
        <property type="protein sequence ID" value="SPAL_0001527100.1"/>
        <property type="gene ID" value="SPAL_0001527100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895911" evidence="2">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001527100.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11505" checksum="BA950AA72A2DFCF0" modified="2015-12-09" version="1">MKFLIFFLLTFKILITFEQSISCRLCIDVINEVKKLIDEDEPDIISKMATICDKVTFKKQPFDSICRKYVVRKGDEIIKYIEKYEEPNIVCSKLHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBK9</accession>
    <name>A0A0N5CBK9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBK9"/>
    <dbReference type="WBParaSite" id="SPAL_0001527500.1">
        <property type="protein sequence ID" value="SPAL_0001527500.1"/>
        <property type="gene ID" value="SPAL_0001527500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001527500.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60125" checksum="F14B2536E02C1EAC" modified="2015-12-09" version="1">MLIKYFTLFFNLFSLLYSYKILVVNPKFGYSHVNFFSQVADILTEAGHDVTVLTINIDPTIKHPGAYKAKIITYQSTKEVEDNFANMFDNRFLWTLSNSGTEQFKLMLKFINGVHKQSLRVFNDEELTEKIKKEKFDLGITEAVNVYILGMFKVWGVKAYVAGYSMSLGDDLYKLFGLPFPASFMPSLMSSFTDKMTYSERFENWFVHNFGEAVFYFLKDKMTLQSEFDEKFGVGFYDSDNIIGDSSFLVLNSNPFLDIPGPKTPKMVEVSGIGIKDPKPLDEYWNKILSLRNKTVLVSFGSFAKAIYMPDEMKNGLLETIKKLNDITFIWKYEEPEDGTGKDIENLVINKWLPQSDLLNDERLSLFVTHGGMGSTTELSFRGVPAIAIPILGDQMRNSKLIERQKCGIVMNKFELADSSKLIKNIKTILDDDTYKKNAKMVSRRLNKRPIGSKRLLIEHIEFAAEFGKLDMLDLASRHMGIIEYYNLDIILPVISGFIVFVGLIFFIIFRIVKKLFTKKLKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBX1</accession>
    <name>A0A0N5CBX1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Autophagy-related protein 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBX1"/>
    <dbReference type="STRING" id="174720.A0A0N5CBX1"/>
    <dbReference type="WBParaSite" id="SPAL_0001538200.1">
        <property type="protein sequence ID" value="SPAL_0001538200.1"/>
        <property type="gene ID" value="SPAL_0001538200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001538200.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35837" checksum="6F813F6BBE72497C" modified="2015-12-09" version="1">MTELTSKFINSYVTKFMHKTFQSLVTARDGPKLITKCQPSKTSWFQIEIDEIGSVASVIKQRVRNFPQSCNIVNIDFLLNTPDYGLLPLEQWRITVDRSKKNDGNIVTTEGFYDGLTILLRSIVVAARQTPCQRYLVRKQNEGKFVLAFKIYEGDFKPLFGDNTKYVDLGVVKTNYCHVCASLIYRQDFNYDPDVSDYYKIYDDSPLISKKNSKDCSEICIIEDVIVHIDNTGKSFVDESLYVTSSIFPILEKSETSQITTYGKSTSTFNDDVPKYRRRIMSEMSTTSSEHPIFNMSTSSNRTQKSEEISKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCR1</accession>
    <name>A0A0N5CCR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein PFC0760c-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001566100.1">
        <property type="protein sequence ID" value="SPAL_0001566100.1"/>
        <property type="gene ID" value="SPAL_0001566100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001566100.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="59860" checksum="6226087EB4113A34" modified="2015-12-09" version="1">MKLTSVSIPRNSKCLPPASTPRIIHEELTSESGTLSRKQSFASIVQNRQDYDENSNVILNNSHDTNEPMFQHEEQHVLPDDFDSFIFDTSSEDKLNPKIEEVVNKIHDWIQNEDKHKVYQKEDENDREDFFRWISDEERNKITEDILKCFHIEGEPMFQHEEQHVLPDDFDSFIFDTSSEDKLNPKIEEVVNKIHDWIQNEDKHKVYQKEDENDREDFFRWISDEERNNESGTLSRKQSFASIVQNRQDYDENSNVILNNSHDTNEPMFQHEEQHVLPDDFDSFIFDTSSEDKLNPKIEEVVNKIHDWIQNEDKHKVYQKEDENDREDFFRWISDEERNKITEDILKCFHIEGGGYEILTDVEVEQRYFAKNFDAIPLHLLLVHSTKDLLESLENVVRVPSAGEELYTIEDENFGAKFDVDVNYVETFPRVEIFRSPSYESVSSLDLTQSSYANSSFGYQTECDFDDLVNGVSEIEISHEEEPSMEDFLCEDEDVNVEFPESFFDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCT1</accession>
    <name>A0A0N5CCT1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCT1"/>
    <dbReference type="WBParaSite" id="SPAL_0001568100.1">
        <property type="protein sequence ID" value="SPAL_0001568100.1"/>
        <property type="gene ID" value="SPAL_0001568100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF37">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001568100.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54922" checksum="743E136A01A2FC76" modified="2015-12-09" version="1">MEENIAYLNESNISYVGEDNDDYYISFDDTTELISNVTDENVELQKIANYIIACSSYAYVFFAAIGLILNAYVITRLIQSALSDYDRFKRGCGFPLAVMSLSDLISILGIVANVSASLMTKFGWIQTPTHSISCKIIMYVLHTMTSFSTWCWLFVSAIRYMAVYHPLRQSTRWALGDLALYGILGVSMTLNFWLLFVVNSSYFMCTEISISKTVDFNRIFHIVEFIWSYVIPAALTLFMDIRVIFTKPPGFIEQFQYDKKKSKKTKFLHLSSRKLIEAPKCIHDDVRKTQSRKRSSIKRARCNVWRFLLIVTINQLLNAPDNVFKMMAIIGGNNYTGGNRSLIIHTIALIGRLMYFSQFCFNAAILSIIVYNHTTRPRKMLTYAEQFKKSTLNGYEKTSREYYNLSHEKADSQSALGLLSVSYGDEMLSKKVKNVKKLRKSSSCVIKSTQFKDISVKNNVKCNNAEGEININVPDSNSIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD53</accession>
    <name>A0A0N5CD53_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD53"/>
    <dbReference type="STRING" id="174720.A0A0N5CD53"/>
    <dbReference type="WBParaSite" id="SPAL_0001579900.1">
        <property type="protein sequence ID" value="SPAL_0001579900.1"/>
        <property type="gene ID" value="SPAL_0001579900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF76">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="218"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001579900.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48893" checksum="E1C23C735546A0DE" modified="2015-12-09" version="1">MTSHFPDDDFSRDSGFAFEDSRDSLYFQCITTETTTTETISIDTDSTDHIDIDIYQENSTTNITKSYSKGLTDVTKNYNNIQNSMHLSNKTDLKTFSCHVNRKRAFETSFINDDSIPRRKRIEISFENEVTQHESPKARISKTKSTSFIPTRKAAFSEFTSSLSISCLNEAHSSENVLNEEFVYSLPLVEKPQKPSSAYGSISGETLVNLMSTLGNNFQEKYILIDCRYPYEYEGGHVSGAMNFYTPENIENMFFPKDEYLAKCIKSKVPIFYCEFSQKRGPGMADALRAADRIRNRYPTVSYKEIYVLDRGYKKFFTEDKFLNYCNPVSYIPMLHPDYSSELEKYKHIHKSKTGKDRRERSIKLRTVRSSGTKRVLQFNTEREKKLEMLMAIPSVPPSNVNSDIFNEDSDFSQGINSFCSDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDY0</accession>
    <name>A0A0N5CDY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001607025.1">
        <property type="protein sequence ID" value="SPAL_0001607025.1"/>
        <property type="gene ID" value="SPAL_0001607025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001607025.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18949" checksum="858CBC4675D2F57E" modified="2015-12-09" version="1">LREAIRIKRQIKRANSKARLSDIVYQFVYTYNRSKHLKTGIELAKLLLNTGDSFISSAQIHNGYTGMIPLYQSLHKNVKREQIRRHGTEINVGDKVLKKVMFRKDAKTSHKNQPTCEDPYTVLQCFYLDTYEIQKINNNRKTRHSIEKVHGDMLKKISNDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG53</accession>
    <name>A0A0N5CG53_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosinase_Cu-bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG53"/>
    <dbReference type="STRING" id="174720.A0A0N5CG53"/>
    <dbReference type="WBParaSite" id="SPAL_0001683200.1">
        <property type="protein sequence ID" value="SPAL_0001683200.1"/>
        <property type="gene ID" value="SPAL_0001683200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896054" evidence="4">
        <location>
            <begin position="21"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001683200.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="74547" checksum="383FE6AC874AAF7F" modified="2015-12-09" version="1">MIIKEISFIILLFLSNNGVAQIREDCSDAPNEQIKEICLRFRRMDKMSREQYERQADNALWPPQAPGSPTFQRPIPIPATHRGNYAYDPLECMSLQCLCPFFNGRMMAPDHCVLPNGEPLKMAYRKEYRMMTDDERFRYHRALQIMKQNGQYDALGRQHRDVSSGGGAHSGPGFLPWHREYLKRFEIQLKMIDPTLALPYWDSTLDNYLPNPRDSILFTDLFIGATDWNGYVTTGPFAYWRTLEGAFALRRNVGAEGNLFNEEQINQVIQQTNVEYVLSYVTQTAGCPYPVNYGAIEYSHGAVHRYINGDFGPVPTSANDPIFYAHHAFVDLIFETWRQLRQPRWVRESAYPPDIASCTNPLHFSYAEMRPFPRLINRDGLSNAYTDQLYRYAPRPTCTLAEPACGSRYLFCDTRGYPHCVAKVRLGGMCNGLEGLDACYNGQCIFGRCVPGPTPAPFKPFIASTTPRPPVVLRASTKKAKGLVTETLRNITNAIRNSAQQNKNKSRTRVVGKEKFVNSTIVTFVDCFDKNPCCETWSLIGECSDNPKYMNLNCPMSCKKCKPSFSILDTCKDRHVSCKQWRSENQCSSSTGSHLSFLQENCRESCGLCRTKKSDTCAIPKRKRKLAEELNIHTNLTKKQSLKKDEINLRRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGY3</accession>
    <name>A0A0N5CGY3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Essential MCU regulator, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Single-pass membrane protein with aspartate-rich tail 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SMDT1/EMRE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGY3"/>
    <dbReference type="STRING" id="174720.A0A0N5CGY3"/>
    <dbReference type="WBParaSite" id="SPAL_0001710800.1">
        <property type="protein sequence ID" value="SPAL_0001710800.1"/>
        <property type="gene ID" value="SPAL_0001710800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018782">
        <property type="entry name" value="MCU_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904:SF1">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10161">
        <property type="entry name" value="DDDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001710800.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9760" checksum="328638622A701842" modified="2015-12-09" version="1">MFGFLGKLSGKILKLKPIVQNNRYVCKNFRQDTTIVSPPPFLVSMGGFKFVLAICSSLYLGSMIAKYGASYLEENEIFIPQDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH31</accession>
    <name>A0A0N5CH31_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5CH31"/>
    <dbReference type="WBParaSite" id="SPAL_0001715500.1">
        <property type="protein sequence ID" value="SPAL_0001715500.1"/>
        <property type="gene ID" value="SPAL_0001715500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001715500.1"/>
        </source>
    </evidence>
    <sequence length="1328" mass="154163" checksum="F56331D976344A7C" modified="2015-12-09" version="1">MTNSATEEKDSQGVKDDIVTKKEEPLTKNELEKEYDMILEETKVTLLEMCSIKTLKKNLMTRLILENIYPTRILDIHEIYEGKELQALSASRVENTDTVDNIVPKIDASIKLSVDKKDTLLVCDNKNSINSLDNNSTFIDMNLQDYPEFKEPMYFDDWVKIMERIFRIKTVTDEKMKIDIVMTKLGERGLWFTVDENSYPNCIAQLSSKFKKAPTDAQLLIEYGMMQFNLTTKDVEKVAEMTLKCYKNETEQRQIAEFTGKLITRAKTTFLQYVIREAATKSRLNDAVQMIIMALGDNMDKPREKKRCFWCNYPGHVENVCERKKKGLEKKDYYTENMQKHQRNNNKEVMLINSIDSANEPREGEVMLLSLDGIEDDIDDSKYMKVVLTRDNAVIECVAFKDSGADIPVISKKLANQLNITNLTDMKVKSFGGIVETKVANQLNPEVVVSMGNYESKLCKTIVEDTGYEMILSRNMLNEWKKYQHKVVINDKDVNNKDKHIKDIENKFNSIIAKDRFDIGCCTLKAPETDYKFKEMKKFVRYDPNKDIITVLKKDIQPLLDKHIISRGIPKYNLNIVPVKKSDGSYRICLNMQPYNEMVQKRSYCSPKVTYFFEHIGEYKWLSKIDITQAYLQIKWHENNKNDVGFHLGSELFILNRLAFGFVNAPAIWQELIDFMMQGLPCLSYQDDIIHVSNKSMSQHILEDHQILTRLQQHGITINFNKSIFAVQREFYLGRLLLPHGLSIADKYKHTLRNMKVPTTIYELRRLRGLVNYMAEFVPNLALMEKRLNRFIGGTPKSEGRKKVEISPEILADIEQIKIAIENAPVLAYIDFKKPFYLFTDASEEGMGALLAQPISDSINIKAPNLKLMRPVLLWSKALQPYKKITPIVVLELRAIAEALLYFRHVVFGRDLVIYTDHRNLISIIQHGTDPRYSKYIYTILSFTPRRIIYINGDGNSIADFLSRMPMHSTEEGGEIFTIENIDQNNEMPNFNIESNMSMEKLVELLFDETHLKMSHLSLNKLYPLVKNVLVQKVKKLRLIRRVMGMLRKKISNCTVCIKHNELRRKKLITDEIKKPFDRVDIDVLFFENHSIMIAIDTFSGFVTARILKSQNVQQVIEFLELEIFTKWGLPLELHCDNYKTFHAKEFKEFLFKKNIRVTYSIPGSHSTNQKVERAIRTVKSLFRKEIEQHGNFIKRIPQILFNYNAAPDEILQISPIDILYSFKVRTTPIENHEGMENLQSLELKLLDNQIKKLPTAVYVKDLLASSNRAQPRNKLIQLNKNVNESGRERILHQDRKIIPLLKCRWEATGSSTKDFKGERGEWSDATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIW8</accession>
    <name>A0A0N5CIW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIW8"/>
    <dbReference type="WBParaSite" id="SPAL_0001777300.1">
        <property type="protein sequence ID" value="SPAL_0001777300.1"/>
        <property type="gene ID" value="SPAL_0001777300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001777300.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14350" checksum="768EF97112EEC329" modified="2015-12-09" version="1">MTPGIFDSLTSLSKEDRLLLFNAFTHSISTNLKNLNQNFDENTSTLQGNIMDTQKFLVREIFDIKNQLNTINQKLDWLIDNRKQEIIFKNNHNDGKKNLKEDESHLEEIVEIFKKINNSLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2B7</accession>
    <name>A0A0N5B2B7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2B7"/>
    <dbReference type="STRING" id="174720.A0A0N5B2B7"/>
    <dbReference type="WBParaSite" id="SPAL_0000022300.1">
        <property type="protein sequence ID" value="SPAL_0000022300.1"/>
        <property type="gene ID" value="SPAL_0000022300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000022300.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39778" checksum="221F18FAEB6EF6DD" modified="2015-12-09" version="1">MSLSTFSTSQANLAIQILNEFIKNDDTSPIIYSPISLAIALSMAYVGSSGSTKEQIKKYLFDDCSDEEVHKNFNKFLINVQEDDKNNLKSVNKIYIKEGVKLLKLFTQTIEEYYQGQFEQINFSLPDACDVINKFVEESTNNLIKDIIKPDDLNDATYMILINALYFKCEWANKFDENDIIEENFHVNKNKTKVVDLMYNMNEYLFFKNNEYQLIKLNYKNNRQSMVILLPVEMCALHKMLPTLNGEQLFHMIDSLESKKVHLYLPKFNIESTHEMVETFKKLGLTIPFSDHSDFSLITNKAPLRINKIIQKAFIEVDESGSEATAATFVSDEVDCAAESEEPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2C0</accession>
    <name>A0A0N5B2C0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2C0"/>
    <dbReference type="WBParaSite" id="SPAL_0000022700.1">
        <property type="protein sequence ID" value="SPAL_0000022700.1"/>
        <property type="gene ID" value="SPAL_0000022700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF5">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000022700.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55573" checksum="C3845E346031A774" modified="2015-12-09" version="1">MFIYLFIIIIYYFYIPINGLINVSNFSLDKLLLNDETNDGLRYKLSTKFSVKANAVGDKCVSHFDCIHFNAGCAFDQQTKIGVCLYLCDSNRTNSKGSCNDREICKEEADSFTSKNLYLPLPMCIPVECKEDNHCDINEICQENYCVVKTVLAENITCSTNSDCVDEDTVCDRNEKICSSVQCSTDNECSNFNGICNVGTNTCIQIPQYCNNNKDCISKAYVCDTLIQTCILEDVSSNYHCRDHKDCQKESSLASICDKSRNVCIIPPTCKNNFNCQKTTGYCDMNTLTCNVKESNIVVFNRPPKFNTGKVKSYETEIQTQPKDFVCFSDQDCTVANYFCDKSTKRCRENKNEEFVEIANTISEMLTLKTSCVDVAGNCKKYVKNCLNPKYKSMMKYACSRSCNFCSDSIKTKKHYKKNTSPPESKVILNKIPKKVETPVCKDNIRFRHHVINCEDRKNLCKQKMYYEFMRVHCSKTCGFCKETPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2E9</accession>
    <name>A0A0N5B2E9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COX6C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2E9"/>
    <dbReference type="WBParaSite" id="SPAL_0000025600.1">
        <property type="protein sequence ID" value="SPAL_0000025600.1"/>
        <property type="gene ID" value="SPAL_0000025600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000025600.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10493" checksum="D106C4FCAE6833DA" modified="2015-12-09" version="1">MILRGSDGQSYWKETSELKLPKGGRVLSIIPKSLIAFSGIIVLFTYVSFQADANPDSKYAYYYNKLVRSSMGTLEEYSNPMRQIGKSENEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4V4</accession>
    <name>A0A0N5B4V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear hormone receptor HR78</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4V4"/>
    <dbReference type="STRING" id="174720.A0A0N5B4V4"/>
    <dbReference type="WBParaSite" id="SPAL_0000110400.1">
        <property type="protein sequence ID" value="SPAL_0000110400.1"/>
        <property type="gene ID" value="SPAL_0000110400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="363"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="593"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000110400.1"/>
        </source>
    </evidence>
    <sequence length="937" mass="101303" checksum="AADFE255B26051B3" modified="2015-12-09" version="1">MALVNAESQHNQKIQDIIHNQHSPTSSILTATSTSSEDSISPLNTPDRKLLSTTTNNINSFGIHNKTINHLKKDPTTSAFKTFQSSTPTSTSIGSGQGITSNNLSITLNQHNLPNATLSQINPLNLSAIDSRLLSVLSEEHQKQSSVGIFSTNLQSAFKTSTQQQQPQISSFGINHQLDKSNSFISSASTTPSTNLDPSTLMAAQLGLLNSPNALLTMMQAAAAQNLYIHQKQSEMNSGSGTSNGQVSAVSLLSSNNGLVRNNPGSLLGQQSNTILQQANILTKMYPSLYGSQPFLLNDHLESGTGIGSSVSTNSTISSHHSNPCNVFNSQLNTSNISCNTPRNITISNTQSTGGSMPRDMCIEPCVVCGDKASGRHYGAVSCEGCKGFFKRSIRKQIGYVCRGNKDCPVTKFHRNRCQFCRLKKCLAMGMRSESVQAERRPMNISNSSNNNNGSANNATPNNSLHSQNFNGLQSSNQNGRLNGLSDNLNLPSGNTSSEGVGNLLQASNQRSTIENGSLASNLLGFNGKTSNLSYMQGLLAIAKNEGSITSSCKGGNENRKDSGTYDSSSSSGISCNSPDETKLQIKRESIDEDENGIDMTSVGLTASASPLSSNGGGCSLSDDGSLIIGNVIDPDTAKFELLINQPIPQDLNIQFFCEAASRLLFMSIHWLKNIKVFSQRDIYVENTMKLKWCDIFVIGLMQCNQDFNLSVMLTAMGNHLNTCVKFGQLKPEKYDEVAEQISRLLTMIKKFDELKLSGIEFAYLKTISFTASDLPELMTTHVSRQINSAACTELYEYLNNNLNSSSSSVTGTIDDSHSETDCASSSPGTTSTSITSHSQGSCNIIDRYSKIMMLLSSLRWLKQSVLVELFFSGLIGNSSIETVIPYILSMDWNGILDNNQTSDNRISSSPTIKVECDDPSNIINNNNNTITQFVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B597</accession>
    <name>A0A0N5B597_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B597"/>
    <dbReference type="STRING" id="174720.A0A0N5B597"/>
    <dbReference type="WBParaSite" id="SPAL_0000124200.1">
        <property type="protein sequence ID" value="SPAL_0000124200.1"/>
        <property type="gene ID" value="SPAL_0000124200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000124200.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42666" checksum="B880DBAD8C8EB814" modified="2015-12-09" version="1">MLNPLFFPENYNYYICNKDELNYSVELLNQKPDIMAYVFLIAGIIFIVIYIPCILVMLKNEFYNNSCYKIMVFLSLIDVSAVMVNSVATGIFGILRLPYCFSPKLHLAIGSFGVSIWCATCATATILAFNRFLDTTHKSLCFKLFDGKKTFIWLILPIIYFLYFFFFTSPLAFSQIYMSWFFNPYQDYLELEKSRRNIDFNSIPHTINNFLIIIFMILGYGAMFLKLSRKSNKISTPSNTSLVLVKVQFQVFIICFFVFAAALLYVYMQFFPVPPIFAVISQILWSFAQGCGGVIYITLNPTIRQAIWRDLLDKKKLLTITHYLSKKKEMLLKEESLQKYDKEILMLSGYYYYFCNSYYHFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5B4</accession>
    <name>A0A0N5B5B4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5B4"/>
    <dbReference type="WBParaSite" id="SPAL_0000125900.1">
        <property type="protein sequence ID" value="SPAL_0000125900.1"/>
        <property type="gene ID" value="SPAL_0000125900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="176"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000125900.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47530" checksum="E67233A3F94C212B" modified="2015-12-09" version="1">MTSDICNIGELETSFSTKSSVSTKDLKNKKNIILTNDSECYASFRIDLPQCEQFLIEPSLGIIPPLSKKIVTISNCCKNEAGGVVNQLMTVYTKYVTECADCINFWTAAEDENTKKHYLTIMFPEDEDSGIENSIYDSNNINVSMNSLSTISFDNNTSSRTISESSVEDFFCEQSTPVILYHYDKCYTIDKTILQSKSKKFDRIFEKENEISSFKIPRPFVSEHVDEMINYLTFNFCNFSTTNIYGVLRLAFFYEIEELVMDGENWVEANFDYLNLPILYHFLTEFSRDNLISSLLEYVRSNFENLFRNDLFMEYDFVFFSKIFCEIILPDVDINRGVIMFMEWINYDYVRRLSYFKWLVSLDEMRFLSKNFIMNMGTTYFHFMSNIDFNIHYVILLTKACGCLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Z5</accession>
    <name>A0A0N5B5Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Merozoite surface protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000148600.1">
        <property type="protein sequence ID" value="SPAL_0000148600.1"/>
        <property type="gene ID" value="SPAL_0000148600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000148600.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25342" checksum="56B0B6E9972508EF" modified="2015-12-09" version="1">XIDETQNNNSNIANNTQTPAVETTTLVQTSSPVVAENSPVQNPSNIPESESEDTTSQSPSNPPLTLSTQPSEILTESGSGVEITTKNNDIQTTVIQSSVESSTSSGNLKNEEAAINNHSRPLQNNKFQKILTGSTPTFTTPSNEITTSPVINQETTTSISVPLNKSAELDTSTENTNNGQINLNNETITTSTTTVVPGSESKEFDNSNESGDLTTKLQDAPEVSTTATTTISNQIDTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B602</accession>
    <name>A0A0N5B602_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B602"/>
    <dbReference type="STRING" id="174720.A0A0N5B602"/>
    <dbReference type="WBParaSite" id="SPAL_0000149300.1">
        <property type="protein sequence ID" value="SPAL_0000149300.1"/>
        <property type="gene ID" value="SPAL_0000149300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000149300.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35978" checksum="3A97440D13ED3C0C" modified="2015-12-09" version="1">MVNKILGIDNSFINLELFEFPDGSIFESTNDDLSPKKNLKRCEAFIFVIDAQGDVDEALKLLSQEILEAYIINGEIYFEILIHKIDGINEEARMDTKRKIFQYIQDWMMEEEIDDIKINYHMTSIFDHSIFEAFSKIVQKLLRKIGSFESDHSIFEAFSKIVQKLLRKIGSFESFLDMFNQGTNIEKSFIFDLTSKVYIATDSAPVDMATYELCCDMIDVAIDVSTIYGKNKSGITFNEYSAAQFTLRTKQVLFMRPINKYLALLAIARTENCENESTINFNLKEFRSCVYDVFEIAKRKMSRKIEGNVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B620</accession>
    <name>A0A0N5B620_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B620"/>
    <dbReference type="STRING" id="174720.A0A0N5B620"/>
    <dbReference type="WBParaSite" id="SPAL_0000151000.1">
        <property type="protein sequence ID" value="SPAL_0000151000.1"/>
        <property type="gene ID" value="SPAL_0000151000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02667">
        <property type="entry name" value="Peptidase_C19K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF39">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="43"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000151000.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="67208" checksum="42E8A5DD8572B182" modified="2015-12-09" version="1">MNSLNSSVENGKSPNDKEKYLKEKKEMSPIDKSSSNNFASQPCGLSNLGNTCFFNSVMQCLLNTHVIKEYTLNVSKQTFLEVPKRDVYINDNKVSLEKMNIRVDAQKCRLTESFKKFYITFTSMKRVDPKDLFFEICAKADRFRGWAQQDAHELLRYLMDGLKTEEIDRFKRAIVNEFQFPISGKEAKPEHAQFARAILEVGRKPMIDRVFGGSLVQTLTCCRCKYVSSRLEPFMDLSLPLASMTATSPIVKPIINYGNNRHPEAKKAKKDNKMRNGLNRGNDDIDNDFVDEELEERKDDYDDSSASGHEDDNDIDGEEDNDSFDNFPINNNFNYSPNRLDRYRETLGDCDEQYCNNERSVYNCLKQFTSEEDLTGSNSYECEKCCLEFNKKKLKENPKAKKRMVEAKKKYLIYSPPVILTLHLKRFEQVHNSIIARTRKISGYVDFDFELDLSPFVAKHGQRIVPGEKRVLYRLYGIVVHSGGLSGGHYIAYVKTRRPIPYIKDFFDNAASYDDFMKEITERDEDKCLREIPGKYNELHEEFNKDGKWYYCSDSSVHAVDQDQVSKCEAYILFYERMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6X0</accession>
    <name>A0A0N5B6X0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MTS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6X0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6X0"/>
    <dbReference type="WBParaSite" id="SPAL_0000180700.1">
        <property type="protein sequence ID" value="SPAL_0000180700.1"/>
        <property type="gene ID" value="SPAL_0000180700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000180700.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20028" checksum="EF71484F6BF0C4AF" modified="2015-12-09" version="1">MKPLIVFEIGSGSGVITAFLRNLLEPAINFISFTSDINFNACRCTQETCSINKNEKNVDSICCDTLKPFFPRICNKIDLLIFNPPYVLTEDIPRCEEELCYAGGPNGRHVLDGLLPKLKDILSVGGRFYVIATKENDIEYLVNFNDDGHLECSVVGNRIRGCENLFVLMYKRLPLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7C7</accession>
    <name>A0A0N5B7C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7C7"/>
    <dbReference type="STRING" id="174720.A0A0N5B7C7"/>
    <dbReference type="WBParaSite" id="SPAL_0000195300.1">
        <property type="protein sequence ID" value="SPAL_0000195300.1"/>
        <property type="gene ID" value="SPAL_0000195300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="104"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="314"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000195300.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52026" checksum="524EB1DB56F096ED" modified="2015-12-09" version="1">MIFIIDKLKILNQYEIKNKLLLIIFIVIINLTATVNTGYITRYGIEYDHKTLNELLPEFTGKDSFFSKETNNDFGEDSKGLSRDKRYIISNESTIPGCNDDAVILGWLLKDYNYLQIPGNGHVKVEVEIWIQEVSKIIEITSEFEVDLYVTEMWNDPSLVFSHLSPCKSNMSVDGPKVIEQIWKPQGCFINSKDAKIHSSPVKNIFLQIYDNGNVWYNYRIKLIGPCSNMLKSFPIDTQKCSLFYESFNHNLAEVEMTWTAKPILILKEVKLPDYILIDNYTTTVRRLYPPGVWNELIATFTFQRLYGFYILQVYVPAYISVFISWISFYLGPENVAPRTTVGVNALLALTFQFGSVISNLPKTSDVKAIDVMILICMAFIFLSLIELALVGFLSGGPKKERIRINLTWLFPSLRQYYITAGQVDFVSAIMFPSSFLAFNIWYWFFFLGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B831</accession>
    <name>A0A0N5B831_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B831"/>
    <dbReference type="STRING" id="174720.A0A0N5B831"/>
    <dbReference type="WBParaSite" id="SPAL_0000220400.1">
        <property type="protein sequence ID" value="SPAL_0000220400.1"/>
        <property type="gene ID" value="SPAL_0000220400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000220400.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17644" checksum="31494723F68E1A1E" modified="2015-12-09" version="1">MDKVILTENGKRMRDKDGYRLRAAGIVTLPTDNSSNPKILLVSGIKNPSNFVLPGGGIEKEEDAKEAALREVKEEAGVICEIMWGVGEFKDDVKLQRTFLYILKPVRILEEWDDRRRGRTRSWIPLNEALEKIKPRQRIMIKAYVDRVTHSPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8A9</accession>
    <name>A0A0N5B8A9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Pseudopodium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8A9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8A9"/>
    <dbReference type="WBParaSite" id="SPAL_0000228200.1">
        <property type="protein sequence ID" value="SPAL_0000228200.1"/>
        <property type="gene ID" value="SPAL_0000228200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097723">
        <property type="term" value="P:amoeboid sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031272">
        <property type="term" value="P:regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF199">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000228200.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36811" checksum="ABB4602540EF340C" modified="2015-12-09" version="1">MVVEYTVTKVETNLSFSIEKMVTRVLSVAKDGQILEEIVSIDEIKELINATKHIFIQQPVCLEIQAPVTICGDIHGQFHDLLRIFYQGGFPNETSYLFLGDYVDRGKQSLETMIFLMCYKILFPDSFFLLRGNHECYKVNRHYGFYDEISRKYHSMDLFEAFGSMFEYMPISAIVGDKILCVHGGLSPELKSRECLMKIKRPVCPYNNSFVCDLLWSDPDLLTKGFSSSTRGVSYFFGTGITNKICEDLKIDLICRGHQVVQDGYEFFADRKMVTIFSAPHYCGQYANSGAFMTVSGELACSFTILKPFINTKKVSGPVIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8C3</accession>
    <name>A0A0N5B8C3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8C3"/>
    <dbReference type="STRING" id="174720.A0A0N5B8C3"/>
    <dbReference type="WBParaSite" id="SPAL_0000229600.1">
        <property type="protein sequence ID" value="SPAL_0000229600.1"/>
        <property type="gene ID" value="SPAL_0000229600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="283"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000229600.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70202" checksum="9248A24B5F84D1DD" modified="2015-12-09" version="1">MNRKSDIEKCMELISYEFTCDDIRHCLKRLSCITAGNKEVIQQRLIQKLKNKETQKKAIEAILYKGRVGCYSSNILEVSSEKDNKARNGFTDSETFIPVKKLYFHKNVKNLSGWKIVSSRDISGLSLFNLKLSSEMRSSILCSKDSKPSKKCLMLRCVEISKENDLPFEDCYPLGMRMFINSREFTDLLPREIFYSNLDLKHRLNAPTNLNKAVFKLSKTSTLEDPLQMKICFDRSLNIGSTFAFAVFSSTIKTAEELVFQITNKARRTVEEFRSDLEECLSGGKGVIIESIKVSLNSSISLERIKIPFWGRNCNHIFPEDLETYIMINETTESWLCKYCKSPCTPDDIKVDEFFTKVLQNHPYINDIELFPGAKYRIPGCKEKLSIISSKVVKGGENNNDTVVLESDDEIGDLLFGSLSSDESSGGENNEKHSPLIVNSNNNKIECIVLDDNSDDEQPPKVSKPRGLIICSPKVLVNKPKAKRSRKRPTPAVTHNPDVIDSSESSTSPRESPRCSEMSTLMGRVNIFTSTSVNASPSLLQQAPEFHQTSIDVFKDRIAKNCPIFTEVIKKLITNSNFYEMYISSKPEDFRIWKPIGISDELWELLTMPEVRSLFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8F1</accession>
    <name>A0A0N5B8F1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L39, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8F1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8F1"/>
    <dbReference type="WBParaSite" id="SPAL_0000232400.1">
        <property type="protein sequence ID" value="SPAL_0000232400.1"/>
        <property type="gene ID" value="SPAL_0000232400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000232400.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49623" checksum="0321E7B9D83796EC" modified="2015-12-09" version="1">MVFRKYRAVKDFSKNNTRIFKDILRAKNARNMPKFEVPEALREKKIKIYDPNFESFVSTPNPILEQFKNTNLNSMNINKPDIKDHPLYKKKECLLFESEEPFSDGVDQACNLTNAILRTEFPSIFHDALKKITIPKGFEDEVKDCILGGERFDPTLEKLPRRFDPVLFWIVHPRIHGTPVVKRGNIILANICRKFQILALGNDEMKETRVDFDAPLSGMLSLPGNFNNKPLVVRGCPHITLQNVSPTKLWSSLEIVKGTKDEKVPELRAIEATLDLRKENIYNEESIIVRSNFPLFINTIMYTMENSQKYPWTREQLGANVIMNCFGAALAQARRTTSQNMEIKTIDEIEKELQERPLVTKAIQLCDGKLDIAVFQLNSLLMNKKGIKNEVWLKSNLQLYKTKPYWENMDTVEELNMETVEDFCKLVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8I1</accession>
    <name>A0A0N5B8I1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8I1"/>
    <dbReference type="WBParaSite" id="SPAL_0000235400.1">
        <property type="protein sequence ID" value="SPAL_0000235400.1"/>
        <property type="gene ID" value="SPAL_0000235400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000235400.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29137" checksum="21511EC593B2621B" modified="2015-12-09" version="1">MVVSDLLKQIFISRNNNKVDDLTLLQLEILLKQGYPVYIHTILREDDTNMISIEVFSIHLTPIKEGMKTLPNIFLKNALNSFLYFSQFNAWLVSKVIPVNIKHNSRISLQKTLSKDIKDCIVEKKCFPLTIIDNNVVNVSVEYLKGNFPSDIKSKYPIAKEVYFNSLAPENSVAIFGNNYKFYCDHLLIIEKKLFLKEFIERGINFAKMPTFSHVILRFNKREKTISLLLLQKNKNKKMIDFRKHNSKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Q1</accession>
    <name>A0A0N5B9Q1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Q1"/>
    <dbReference type="WBParaSite" id="SPAL_0000276700.1">
        <property type="protein sequence ID" value="SPAL_0000276700.1"/>
        <property type="gene ID" value="SPAL_0000276700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000276700.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26838" checksum="22014EAB5BD4E2C7" modified="2015-12-09" version="1">MLKIEWISERRLSFALTIALTRELVIQIGEKERKFCDGSEYPCAKLMYLLPLDEVQIEICKAKLKKLSDGCLEFINSTSIECHVSQKNVKICKPYNVYYVVRHIGLAAFKQSTTRRSKNNKNSDTKQKTAGTSKKKSMSLKEKGKKANGAGGNGKKLSSDDGPKKKPSNCGVNNNEESPKMENGNNAVKSDGAPEGNVGDGTTTQNSNRKPNTFHKLLDVPNNAFDCPEKTKKNNVNSYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9R4</accession>
    <name>A0A0N5B9R4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in an early step of the mitochondrial complex IV assembly process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9R4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9R4"/>
    <dbReference type="WBParaSite" id="SPAL_0000278000.1">
        <property type="protein sequence ID" value="SPAL_0000278000.1"/>
        <property type="gene ID" value="SPAL_0000278000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000278000.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10756" checksum="950020DB479C6D9F" modified="2015-12-09" version="1">MASLNTQVYRGYNDPEVDSRPSTGRSCDKLRQELKRCIKESPCVQIDGRKAKDCLDARDGSVPSRCYDLLSNFSDCKRSLVDMRSRFRGRKGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA73</accession>
    <name>A0A0N5BA73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA73"/>
    <dbReference type="STRING" id="174720.A0A0N5BA73"/>
    <dbReference type="WBParaSite" id="SPAL_0000294200.1">
        <property type="protein sequence ID" value="SPAL_0000294200.1"/>
        <property type="gene ID" value="SPAL_0000294200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF3">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="396"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="620"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000294200.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="82659" checksum="F288C5ED940F438A" modified="2015-12-09" version="1">MVEEISNDGNWLEDFKKIGHSEVNGKKYGTSCAISIFGKCTSSEDFLNQIHHKLVDLTENKEQNVLTDKVDDPKKNSSINSSIEAASLKIFITLIKHYTRYAVSEMKQCKNVKGVPSEQRGFKISDKEHVIVINEILSFSGKNGFLLTKYYVEQFPHLLSRIDSFFDNLVDITENGNVHGGILNYIFLTKSFRKFITDVKLIEKYFLISPIDAEILKAVVNNNFIERDNEIIEMFRRIKRCITDLEFWQYHFEDAFNMKPTSESHSDFLVNIERFVKHYKRSPPLKGPLPFKNAVGYLYYTIKKRYVQKNINDNEMNDVAFTVISQHPHIKRRFLFELQKYKDTKAWIMWKRLYIPQCCFPVSFPFAEVNTMKSCGDDNLFLTLPEDVKVFFCSSSAEINNAIDTIYAADKEGFCAVGFDCEWSHIQHPQLVSLIQISFNNFCFLIDTIFGCKESIKKLFEALFYSNNLMITGLQPQNDLKVLLQEYNDIEALYKPKHVFCLSSLIIEINKHKSNKYDNENSDPSVAGNFDFFSSNWRDEVENLKNISSDSKEKVNEDNVVLASNDMDSETLKRQESVTEIDKSASDYCSETNDVEMKSDKCSKNTKKKKDKQLTEIEKFEKYILSLGLSKLCKFFFGKELDKTEQNSVWNRRPLRNKQIHYAALDAEVGCMIFRKLASFCQILEIDIEKIARELPSTVESTYRLLELYEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAX8</accession>
    <name>A0A0N5BAX8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAX8"/>
    <dbReference type="STRING" id="174720.A0A0N5BAX8"/>
    <dbReference type="WBParaSite" id="SPAL_0000319200.2">
        <property type="protein sequence ID" value="SPAL_0000319200.2"/>
        <property type="gene ID" value="SPAL_0000319200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000319200.2"/>
        </source>
    </evidence>
    <sequence length="360" mass="40446" checksum="6123E11313E17A2E" modified="2015-12-09" version="1">MVNKSSLGFLKKGLPFFAIIFGGVYGLQFFQKVRYDFRQVKKEEVSLEEVKEGLQEGGLRVKEKVTVDNIFQEINEIDTENWQNIRGPRDFESNEEYLKAKKEQQEVAVKIRKERKLVTSEIDNTSGKFDNKEEQEDKEKKEIDVTEIVTEEDKQLYYDEVVGCIIEFGISDNVETALLAAKRTYPLGVDAAIDWIIERSNQSDFESSSSESEDTDLDMGGYTSQPVSGDVLSQLNTLRKSLRKYKMVLVVNMALGMGKGKLAAQVGHAVLGTYKHAMKTPEGQTAISHWEKVGQVKVVVKGQDTEQLMDIFKASKDKGLWSYIVQDAGYTQIPPGSRTVVGIFGPVEDVDDVTGSLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB59</accession>
    <name>A0A0N5BB59_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB59"/>
    <dbReference type="WBParaSite" id="SPAL_0000326900.1">
        <property type="protein sequence ID" value="SPAL_0000326900.1"/>
        <property type="gene ID" value="SPAL_0000326900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000326900.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60507" checksum="AAFA84373DF23506" modified="2015-12-09" version="1">MLFKSFILFLNIFPLIYSYKILVVNPKFGYSHVNFFSQVADILTEAGNDVTVLTINIDPTVKHPGAYKAKIITYPSTKEVEDNFLNMNDNRVLWNLSCNGVEQFKMITGFINGIHKQSLRIFNDDQLSEQIRREQFDLGITETLNVYILGMFKVWGIKAYVTGYSMALPDSHYKSFGMPFPASFIPTLTSPYSDKMTYKERFQNLLAYYFGEIVFYFIDNKITLQKEFDQKYGVGYYNSRNVIGDSSFYIINSNPFMDIPGPKAPKMIEVSGIGIKDPKPLNEYWRKILSLRNKTVLVSFGTFAKSIYMPNDIKNGLLETMRKLKDITFMWKYEEPEDGTGKDIENLIITKWLPQNDLLNDERLSLFVTHGGMGSITELSFRGVPAVVIPIFGDQLRNSKLIERQKCGIVMNKFELADSSKLIKNIKTILDDDTYKKNAKMIARRLNKRPISSKRLLIEHIEFAAEFGKLDMLDLASRNMGVIEYYNLDVILPVITGFTIFIYLLFFTIKRILRKLFTLKEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB93</accession>
    <name>A0A0N5BB93_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB93"/>
    <dbReference type="STRING" id="174720.A0A0N5BB93"/>
    <dbReference type="WBParaSite" id="SPAL_0000330300.1">
        <property type="protein sequence ID" value="SPAL_0000330300.1"/>
        <property type="gene ID" value="SPAL_0000330300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000330300.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16614" checksum="258DE1CC29FE13ED" modified="2015-12-09" version="1">MSLLSRVAINGARSLKIYPSISCVRATSGVATKIPQFDALSNKPLPVDMKPAKEFMLEKYLTVAFMPFIPAAYFIHGPAMDMALAIGCSIHVYLGWHMVTTDYARPFLYGNTLAKAGRATAIIFAISCLAGLLHFNYNDVGLTKAFEMVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBV6</accession>
    <name>A0A0N5BBV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-actinin, sarcomeric</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBV6"/>
    <dbReference type="STRING" id="174720.A0A0N5BBV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000350700.2">
        <property type="protein sequence ID" value="SPAL_0000350700.2"/>
        <property type="gene ID" value="SPAL_0000350700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="56"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="169"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="778"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000350700.2"/>
        </source>
    </evidence>
    <sequence length="921" mass="107365" checksum="D5DDA7F0C4744966" modified="2015-12-09" version="1">MVGYFQAIPQSYPHTPPHHQNAPPPNSQGYYTPGCEYAQPEEEWDREQLLDPAWEQQQRKTFTAWCNSHLRKAGTGIEELGEDFQNGLKLMLLLEVISGEPLPRPDRGRMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNLKMTLGLIWTIILRFAIQDISVGELSARDGLLLWCQRKTAPYNNVNVQNFNTSWKDGLAFCALIHRHRPELLDYSKLSKNDPIHNLNLAFDIAEKHLDIPKMLDPEDMVYYDKPDEKSVMTYVSCLYHAFKNHQQHAELVPNSETAANRICRVLKVNQENEQMMEDYERMASDLLSWIRKWMPWLADRHDGMTLDDCRRKMDEFRNYRLGEKPPKVEDKGNLETLFNTLQTKLRLSNRPAFLPSEGHLVKDINLAWDGLERSEKGFEEWLLSEMMRLERLEHLAEKFRRKCLMHEEWTNGKEAYLTSNDWRCARVYEIKALRKKHEAFESDFEAHQERVDQIAAIARELNALRYPKIGPINDKCKEIVDHWERLRKLSEARRRLEEVEKVTEKIDTLQLSYAKRAAPFNNWLDSTREDLADVVLVRSLKEVDELLDSHNKFKSTLNAADVEFKEIINIEHEIQSLIDSYGLDRSIGKNPYTDITPATLSKKWSEVQGAVPRRDERLESEYSRQQNNDRLRQVFGDKANTMGPWLENQLEKVISIGMGGRGSLETAISQLKQIQNDIQPYKRHLDELERINQEMQENYVFDCKNSRYSMESLRVGWESLLTSINRTINECENQILLRDSKGIKEEQLNEIRSSFNYFDKDRVGLDEEQLKSCLISVGYNIRPGKDGDHDMERVLSFVDPNRMGRVPFDAFLDFMTRETADSDTIEQCIDSFRILAQGRPYITAEELRRELPPHEAEYCIRGMERYGKNHNTPPGAYDYVAFSKSLYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC10</accession>
    <name>A0A0N5BC10_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC10"/>
    <dbReference type="STRING" id="174720.A0A0N5BC10"/>
    <dbReference type="WBParaSite" id="SPAL_0000356000.1">
        <property type="protein sequence ID" value="SPAL_0000356000.1"/>
        <property type="gene ID" value="SPAL_0000356000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000833">
        <property type="entry name" value="AGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000356000.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60049" checksum="E742D2C117ABDEB0" modified="2015-12-09" version="1">MEGLSNNISNSGNSIRKKHPMTERNPNDFYFIKILGQGSFSTVYLGKEVETGSEYAIKVVKKTTILREKKAKHIMRERDIMIMLTFKTDDHPFITTLYSTFQDETNVYFAMTYANNGELFKYLQKLGCFDEKTTKFYSAEILLALNFLHDNSVIHRDLKPENILLSNSWHVMLADFGSARMLGDNEVANGNDDKKLETKKISSDRSSFVGTAQYISPEVINGDKFGPETDYWALGAIIYQMVSGNAPFKAVNEYNTLKLIKTLSYDFPQGFPTISKDIVQKLLVLEPSKRLGSHGMGGIESLKSHPFFNGIDWKNLTNSQPPELKPYLPASAGEPAFYSDVYCNNTDISPGLNDAQMARLMGFNEFLQDWQNERNETSEFPKKEESNVVAKESSVFNRKTLFARCEEEYDAMMKKQRLEHKYHRFVEDNLILKSGIIDKKKGLFARRRMFLLTEGPHLYYVDPQTMEYKGEIPWSKDIQTEAKNFKTFFVHTPSRTYYLFDPERKAEEWCQAIEAVKAKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCL2</accession>
    <name>A0A0N5BCL2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BCL2"/>
    <dbReference type="WBParaSite" id="SPAL_0000375800.1">
        <property type="protein sequence ID" value="SPAL_0000375800.1"/>
        <property type="gene ID" value="SPAL_0000375800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="16">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="336"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="698"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000375800.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="131257" checksum="8B4FAF013B36A698" modified="2015-12-09" version="1">MKTTIYFWRCTTLLYFLIYLTNSAKVLLHDSYVYKEELPYEYFSEGDKLNDGIDDHPNWEQESYYDEDKNPIVVSTVCNEGKKPSYIKNWIALPKIEKGPAKKLHLEISYSINNCSQSKPYCKEFFDVFYMPLNGGDNGKNKLRNKDNWMHLKNLNLHSAKITKGDQDFIVATIDYIPLSDGVIFGIREENTCSSILRIRIYYKVCPSQTLNQFQLPETVVGVDLYVPTFYHAGCVTNAIMLDSKSTPRNAFCKANGEWELLNDNTCQCIAGYSPNDSGSCSPCTKGSYKSTVGNGICKACPRNSHSYDNGTHICECDIDFYRADNEDPSHQCSQPPSSPVNVRALELKSSEATIIWSNPTYMGHRSDIYYSISCEFCDESKHCVKCSKSVTNSFDPERIEGKQITLKNLEPGRDYIINVFAHNAVSKKAAGNLHNKAIFTFTTAKPFNFKMNTPKLLSHLNNGTLLISWEPYESEKYYKGEENMYYQIEIRNDKDILLMDSIQTALKIENIDIYKSHIIKIRVHDPKKGWSQWSDELMVKNKYNKGGKFSNQQFERIPNDMVIGTGTEKTDTSLYMSITQLYSQNPRIFYIIGCLIVVLLILLNIFYFCHSKKNKKGDYFAELVKSQQSDIPYNLNMTPSHLYYGKQFDSQFLNGFGSATTFVDASVNKTYVDPSTYGDLSVAVKEFTKQIPKSNIFLTGEILGGGEFGDVQKGILHLTGSMKSRNTAEGGELVVAVKTLKKCVTEQEKKYFTMEATTMSQFYHENVLRCIGVVGTNYVEMIVTEYMINGSLINFLKSISPETYSKIKLAHMCLDVAEGMSYLHMKGYIHRDLASRNILLDQFYRCKIADFGLSRNGFNDENVELEYTNAMAKKIPIRWTSPEALEKGLYTAASDVWSFGILMWEIFTFGERPYYDWSHRKIYEEVIQGYRLPKPDDAPEALYRVMVQCWNQDRNERPTFVAITNEIKSYIRIYEDNRDYIANSPLYQCPSDVNYDVARDGSSNNNRMSHNNYFFTSRPSVSQISINASAHRMSNWDIARNSLGDLERQELENALAKFNIQYLIHHLYRMKIFSVAQLANLPLARLADMDITLNEQKQLAVVMDHIVTSRRAVTNVSRNLMSNQAPIVPQFSKTLNKESIDGGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDH3</accession>
    <name>A0A0N5BDH3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDH3"/>
    <dbReference type="STRING" id="174720.A0A0N5BDH3"/>
    <dbReference type="WBParaSite" id="SPAL_0000405900.1">
        <property type="protein sequence ID" value="SPAL_0000405900.1"/>
        <property type="gene ID" value="SPAL_0000405900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06416">
        <property type="entry name" value="GH25_Lys1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000134">
        <property type="entry name" value="Glycoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894211" evidence="3">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000405900.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24162" checksum="76B87D4F1152AE0E" modified="2015-12-09" version="1">MKSYFLTSLLILGSLQSALAVIGLDAIQTISTSTFKCLHNEGYRFFIGRVWESVGNYDYTGMQNIKNAWEGGMEHVDGYLFPCLSSGCAHAANQVEATINKLKAEGAKIGTLWLDIERYAWPADHNSNRNFITAMVNQAQSMGVTVGIYSNYNMWESIVGLDYKAHSNLPLWWADYNGHQDYTGFTPFGGWSKPSMHQYTGTVNGGCGVSMDQTYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFI7</accession>
    <name>A0A0N5BFI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BFI7"/>
    <dbReference type="WBParaSite" id="SPAL_0000475300.1">
        <property type="protein sequence ID" value="SPAL_0000475300.1"/>
        <property type="gene ID" value="SPAL_0000475300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="255"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="530"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000475300.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="100766" checksum="E78D5A872359092D" modified="2015-12-09" version="1">MSNNKIGTQLHKITFAEGTSWYRYNCKVEVLFPKGDRTRDLTRVNADGSGSPVAALEKRNGCKFAVSKAYEMSDYFGSKGLSYAYDGVSNFITNKPLKVMEFTINRDQLGTEFRTLFKNGACKVSFEEKPNFFKVDLANFIDSYGKEEDKVITNCLDLITTQQALNEKENGGAGYIQLKSGKSLTDSTVSTENEESDTGPGRVIIDGFTKGIKFVNIGGPCYALSIDATKNVYYKAESLDKIIKDEIFGGNVPRSSSEFSSRITDLNIKGVYVQTTHRSNGDVFKFRNDLHSGNANNTYLDTKDGSKKTIAEHFKDRYNLRLKYPEWPLFVHKVKKTVKTDEMKETVEELHYYPLEFRLTRWIRHPHQLNKGLIPSAHSTEKDQPISNXXXXYNLNVIGDENLFVKFGIHISPSSALLSSEFPENPKVMVRENQSVRVEGGKIKNENKPAFYSTSEERPLVVVYGNRCDGRTIDSFCQRYVARCRESRIYFNRPSLHSCNTDVDNGTSEEELMQQFTRALGKVSGSSTKPLLILIDEKKIKKSHTVLKVFEQIHDVITQHITYEIASKAQNQIVTLDNVIRKTNSKLGGLNFNVYMTEQSLEKFNIASKEVLYIGLDLSLAVPGTVKQDLNTSVGGWCANLGRKHGQYVGDYWYQDKKVDDAYLIDSKVLEFVFMDIMKKWKDNSHRPPTKIVFFRCGLSDAQFEKSLEVELSRLLELKPKVGKLFGVENFNCNYTFVFVSKQDNTRFYHINQDGIVENIQPGTFISKEFCVGPNIKIYSKTNPSCLGTAKLPLYYLAYDDNVKEDKFTVEKLEKVVNMLCYTYDIIPSAVSIPAPAYIAAQCVKRGNNNLIGFTKTNNAPFQEDDYVVYSSKLNYTNKELGKQRFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFK4</accession>
    <name>A0A0N5BFK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAGKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFK4"/>
    <dbReference type="STRING" id="174720.A0A0N5BFK4"/>
    <dbReference type="WBParaSite" id="SPAL_0000477000.1">
        <property type="protein sequence ID" value="SPAL_0000477000.1"/>
        <property type="gene ID" value="SPAL_0000477000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047620">
        <property type="term" value="F:acylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000477000.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46691" checksum="C4BD4D4DDE51E137" modified="2015-12-09" version="1">MANERKVYDKFKTNVLPLFNLAGIKVTIIHTKDADEMEAVASALDHEEADCLYVVGGDGTLSRVLTGIYKNKDGPLFPIGHFPGGNDNKGILSLRRNVFKSHDDVRLYCESGMAVIEETVAPVFPIKCEISIPVKNEPTTDDNEHKEDKENEEKFEVKTLYSVSGVNGGWFPMVEEHKQKLWYFFGTKRYFTYLWDGLKRFPGEIEVNVTHTKFCPGCKRCLQDVVVAKIEKKKFEREQNNRSVSWWRNLFGSGRKLGGENQNIPKSFSKEPLVVNEECGLPSDECIVSSGIDLIIENEIGSKGNGLNFLIGGSGYNRFEAIKDGWNRTSTGDDCFKSVNEKFYNEKASFKANTLEMTLTKMPNKWTQIWVAGEKIDLTEDFKKALVKIEATKQKFDMYLPKNIRLDLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFX8</accession>
    <name>A0A0N5BFX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide-binding protein G(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFX8"/>
    <dbReference type="STRING" id="174720.A0A0N5BFX8"/>
    <dbReference type="WBParaSite" id="SPAL_0000488700.1">
        <property type="protein sequence ID" value="SPAL_0000488700.1"/>
        <property type="gene ID" value="SPAL_0000488700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003559">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000488700.1"/>
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    <sequence length="354" mass="40536" checksum="1066BA414F04AAA9" modified="2015-12-09" version="1">MGCTMSQEERAALERSRMIEKNLKEDGLQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDYKQYKPVVYSNTVQSLVAILRAMGNLSVSFGNSEREVDSKLVMDVVSRMEDTEPFSEELLAAMKRLWADSGVQECFSRSNEYQLNDSAKYFLDDLDRLGQSNYQPTEQDILRTRVKTTGIVEVHFTFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMHESLKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICFPEYSGRQDYHEASAYIQAQFEAKNKSANKEIYCHMTCATDTTNIQFVFDAVTDVIIANNLRGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG75</accession>
    <name>A0A0N5BG75_STREA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="SPAL_0000498300"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="SPAL_0000498300.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20996" checksum="F657C3CF14162E6E" modified="2015-12-09" version="1">MIATNRTPKLQSLEHSSLEDVQFTTPKSIHRALDGKVNKSNVRSRIRNGLANPRKLFDGKSINRSTLFKQNNSDNMVKEAFDRCNVVSDSRGKISSCKKEDDDYIDLRCTETFLDEPTLEKSNEREKIDQLNNLLSYMEDLSTKDSKEAYISYRKNCTPPSRAGERRNGAIDYYNDNSAMEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHN6</accession>
    <name>A0A0N5BHN6_STREA</name>
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        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="SPAL_0000547300"/>
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            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="SPAL_0000547300.1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4853" checksum="0E8E2AF1417846DC" modified="2015-12-09" version="1">VIQKAHLIFIVWTSRGYVKVRKGDIVINRDILHSQFIVNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI97</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
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    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="1"/>
            <end position="20"/>
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            <begin position="21"/>
            <end position="183"/>
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    </feature>
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            <begin position="21"/>
            <end position="75"/>
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    </feature>
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        <location>
            <begin position="87"/>
            <end position="108"/>
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    </feature>
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        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000568100.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20720" checksum="5CA5BBA7E918D053" modified="2015-12-09" version="1">MLHFFLFLLFNFLYTIHTCGKKGKAPDIGKNERHRMESDKKRFKNNFIEQKSKSLDPNEQNVNGNNENKNGGVKTVKIKKVNVKSGRSLNLNEAKKSGSKRLLKGGPNNEVRVSNVAIVDIVENCKQNEKKVVSKPVTNRDEKTQKKTDKSIDTFKKLVNVPKDAFTSPESAKVPVNPSQYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ37</accession>
    <name>A0A0N5BJ37_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
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    <dbReference type="STRING" id="174720.A0A0N5BJ37"/>
    <dbReference type="WBParaSite" id="SPAL_0000596200.1">
        <property type="protein sequence ID" value="SPAL_0000596200.1"/>
        <property type="gene ID" value="SPAL_0000596200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000596200.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27358" checksum="F1445FD6AC517FCE" modified="2015-12-09" version="1">MTPKVEVKVDEPRKKISETFERGIRAVLLGPPGSGKGTQAPKISEKFHACHLATGDLLRAEVSSGSEFGKKLKATMDAGQLVSDEVVIDLIEKNLQRPDCQRGFILDGFPRTTVQAEKLDVMLEKRKTPLDSVIEFVINDELLVSRILGRLFHPASGRSYHTEFNPPKVPMKDDITGEPLIRRSDDTEEALRKRLVSYHKSTKPLVDYYQAKGIHYGFDASRPISEVAAKIDALCSKFCHKRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJI7</accession>
    <name>A0A0N5BJI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle 14 kDa protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJI7"/>
    <dbReference type="WBParaSite" id="SPAL_0000611300.1">
        <property type="protein sequence ID" value="SPAL_0000611300.1"/>
        <property type="gene ID" value="SPAL_0000611300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000611300.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11977" checksum="BBB7A45F281860FB" modified="2016-05-11" version="2">MRRTNKTGNPSKKSKASNADPTQYFHIIDDTKQNNSECRVTYSQFMANGKPVKTKEDRYRDEPICCVRITLKNYTDNKKVMKEILERSDYVIRTYLKKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK88</accession>
    <name>A0A0N5BK88_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK88"/>
    <dbReference type="STRING" id="174720.A0A0N5BK88"/>
    <dbReference type="WBParaSite" id="SPAL_0000635100.1">
        <property type="protein sequence ID" value="SPAL_0000635100.1"/>
        <property type="gene ID" value="SPAL_0000635100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000635100.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25339" checksum="EEBB14CD934845E9" modified="2015-12-09" version="1">MKPFEVYLFLYNGIQVLGWGSILLKSINWLGTSGTYEDLYKENVFALQVFQTAAILEIIHCAIGFVRSPVGTTLMQVYSRVFVVWGILYAVKSSQVSIGVPMLIFAWSITEVIRYSFYALSLIKTVPYALIWMRYTFFIVLYPLGASGELFTMVAGLNEIHDKKIFTLEMPNSLNFSFSYWWYVVILCLLYIPGFPKMYFYMFGQRKKVLKVDTTKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKE9</accession>
    <name>A0A0N5BKE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKE9"/>
    <dbReference type="STRING" id="174720.A0A0N5BKE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000640700.1">
        <property type="protein sequence ID" value="SPAL_0000640700.1"/>
        <property type="gene ID" value="SPAL_0000640700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026193">
        <property type="entry name" value="NDUFV3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15880">
        <property type="entry name" value="NDUFV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000640700.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10934" checksum="AD36B54CFCCCD3C0" modified="2015-12-09" version="1">MLVPRNILGNNFKRLLSGVKESISAAPKSTTGIEHADAFKQTGLRHKQDFKDYKCSEYLNFNKWSFYDKEVDMMSHRVSQPTNKKPDVAPKVTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL83</accession>
    <name>A0A0N5BL83_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL83"/>
    <dbReference type="WBParaSite" id="SPAL_0000668400.1">
        <property type="protein sequence ID" value="SPAL_0000668400.1"/>
        <property type="gene ID" value="SPAL_0000668400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894450" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000668400.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18652" checksum="C5288D2E229870F6" modified="2015-12-09" version="1">MDKLLISLLLLLNCFNFSYSKPQPSLDLDNLKLFDKIDELRDPKLREVAIAFMETLRLLDNPIKEGDYESLVQGNPIIAENEKQGLKMQKELSNQIFGKLGSITPQKFGASKNQIDDEEETFSPQFFPRNYDVYKDTGFKHKLKEILEILNKKFPQKTHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL98</accession>
    <name>A0A0N5BL98_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL98"/>
    <dbReference type="WBParaSite" id="SPAL_0000669800.1">
        <property type="protein sequence ID" value="SPAL_0000669800.1"/>
        <property type="gene ID" value="SPAL_0000669800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000669800.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12430" checksum="756A64F9FF57A7B6" modified="2015-12-09" version="1">MGDVKNPNEHYGKKYLLSLNKVTECYSYSHGFKDNPDMELHKVGCNEKNDKCLTVNVTINEAKASWLGCASDYCKITENPCNINNIVCYKIIIIESNFSFRLMAAKQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLK8</accession>
    <name>A0A0N5BLK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000680400.1">
        <property type="protein sequence ID" value="SPAL_0000680400.1"/>
        <property type="gene ID" value="SPAL_0000680400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894776" evidence="5">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000680400.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17445" checksum="62D0B0870434BF21" modified="2015-12-09" version="1">MFKSLILVAYLAFAAKAFIELNMSFQFNGILTCNNKPMGNQTVKLYKNKVLFGESELGENKTNSNGEVSIQDKQMIWTNTKVFIKIEHKCGLISNSSCISEDIFYAPKDGFKKVNDTYVWNFEQDLLIMSLLKPETNGEKSTRLITCKDTESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLL5</accession>
    <name>A0A0N5BLL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein TSSC4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLL5"/>
    <dbReference type="WBParaSite" id="SPAL_0000681100.1">
        <property type="protein sequence ID" value="SPAL_0000681100.1"/>
        <property type="gene ID" value="SPAL_0000681100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000681100.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23298" checksum="194DE2149B084CF4" modified="2015-12-09" version="1">MSNFKKIVKDKHMEEKIDFVEFIKSTKKLDLSDSEFPQSCTSKADSDETLKGKKFVDKEKERILKDYRKFSEDTIRVGKIINPKKLFKSSKTCSVFNAIESMDTKDSNEEKRHSNSNPGILNEEDDNIIRLPKFQNPNISKFPDKSEDKKNKSGCSPKNTTRVSIEKPLPEHPRMIKTMHTVDHEDGSIEAYFTEDIVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLV9</accession>
    <name>A0A0N5BLV9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLV9"/>
    <dbReference type="STRING" id="174720.A0A0N5BLV9"/>
    <dbReference type="WBParaSite" id="SPAL_0000690500.1">
        <property type="protein sequence ID" value="SPAL_0000690500.1"/>
        <property type="gene ID" value="SPAL_0000690500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000007">
        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF51">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000690500.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="81943" checksum="94F221B48BB8F7A4" modified="2015-12-09" version="1">MKKGKYIYLLSAINSPSTNDISDEGSGEGSRVNGAPASPPDDVAEKETSNGEKDEKDENTEGLCVDKHDLCKFWSNIGECQSNKDWMTKNCPISCNLCNGSAICIDRHRLCGFWTAINECETNAVWMLSNCALSCKACKGKPTNDISIKGNSNDIIFSESDCTFTPTNEEIVRRRHISISDVRNSNGKFGCVTPLPPNDCRKNLCYHLKFRTFDGSCNNIDRPLWGAAFTPFTRFKKAIYDDGFSAPVASFAAVRPSAREASRLLLSSSAEVTTKSNALLMQWGQFLAHDMSKTTMLNNQECATCTSNQGRCYSVMLSRADPTFGRFMCLPVARSTPICGSGTEMDNTREQYNENTAFIDGSLIYGSSTKDQFLFRKGAFLKTKIVKGKVFPQIDSNNNIVGGDDRANIFVGLAALHTLMVRQHNRIALAFQSINPHWDQDRIFHETRKIIGAIIQKITYREYLPRILGRRTRRILGPYNGYNDDVNPSIANEFTGCAFRFGHGMLQEFYPFLNENFDQVGGVPFNDGMFKSGHIINNGIDPLLRGLLTLPAKMPQRLTFAVTERIFGNSDLGSINIQRGRDHGIPGYVAWRDMCNLPKVKDFDDLNTTITSAVIRNNLKLLYKHVENIDMYIGSLLEDPVDGAIFGPTLICIVGKQFKALRDGDRFYYENRKIFTDEQVNAINNITLARVLCDSGDKMRHVPKEGFNQVKAEDLVDCTTLPVIDLSPWKTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMB2</accession>
    <name>A0A0N5BMB2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMB2"/>
    <dbReference type="WBParaSite" id="SPAL_0000705200.1">
        <property type="protein sequence ID" value="SPAL_0000705200.1"/>
        <property type="gene ID" value="SPAL_0000705200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="226"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000705200.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41824" checksum="E877FBE7C2870703" modified="2015-12-09" version="1">MNFLLTILLCPLVIIYIPLGHVTNVLAARGRLRKWSNSENLSRRESVDSFHSAKSHFSSSSGESIYETPHSSLRRGSSSSRTSSRRSSGSSSSGFSSRISSGSISSIFSDKKSSSGRFSGSFDKKSSSNSFTGSSIIKSSGTISYPIDRANSNSFSSKRNKGVSVCNSWGNIRHHRFSSDGANFYLKYRGFSIESYLSKSSFSNRIYNNVWSDCNYQCYWKNNYEEYKSRVIANINLLRLAHRSGIVKYNDNLDDMAQSHANLMAKRCTLFSQPSDMYGIVVGMSYYPAASVIVTKWYDENRKYNYLSNRPQPGTQMFTQLIWESAASIGVGVARSGEYLFVACYFYPKGNIKGQYRKNISRRRSRWHLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMF9</accession>
    <name>A0A0N5BMF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMF9"/>
    <dbReference type="WBParaSite" id="SPAL_0000709900.1">
        <property type="protein sequence ID" value="SPAL_0000709900.1"/>
        <property type="gene ID" value="SPAL_0000709900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000709900.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="39319" checksum="A3DC1B93A2C63EDC" modified="2015-12-09" version="1">MDTESDFPTFPLTLLPNEIIKVVLEKVDWATLYNLRLVSRFFNEMILRDFNRFNKPKMNEFKVYSQYEDNGKIKIRYFIICELGKKKIERLYSNEDERDVLVEEYLNKVNMKHIKNFDIAVNNYSPLFKIIIDSFDYGTSVENFYFIINNSPIFMDFYNFLKKLNYIGHIYANKLCLSHPEIPQNISLPILHTLRHLFIVECECTKFINRTMINNLFKYNKYLNALAIYSKTTSFEEDIIRNIKRRHDKCTHEPNNHKETTINLARRSDYNKEREFHRFFPCGTYPMSLDLPIFNSIKVNKKCNECNCNNGISIYFLHMDGYMKHSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH4</accession>
    <name>A0A0N5BMH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH4"/>
    <dbReference type="STRING" id="174720.A0A0N5BMH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000711400.1">
        <property type="protein sequence ID" value="SPAL_0000711400.1"/>
        <property type="gene ID" value="SPAL_0000711400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="711"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711400.1"/>
        </source>
    </evidence>
    <sequence length="976" mass="112441" checksum="0380D0CBB901B998" modified="2015-12-09" version="1">MSNKGNKRTGRHVSPSFSKEYVDESRNVSSYSTSSGTDDYVPSDHSESNMEVPRKRGKSESSGKESGKKGKKEKKGKHVTRREAIGRKITDTVGKIKKNEENKSSEASFSDILARLDQQKAAYKGGRSHDLPHEGGSNIPEGEIVADVGMLTIEEPTDKVGRILNIFNDLNNRVRKIEGNIEEMKELFQQQNSEIMEMLGGINLAIHEIKESRRFRSTVSRSKKVYHIWDEEHSLLCDLDEIYIENLILQAHNRYYGENGKRWIENRELQAFPNNNEIVKKAVGYMKDVGKFCKFVADILIPQEYLLKFYFPSKHTRRAKERLFSEEVVKSFEIAAKYLGSRIIIEERKKRLLDILWNSKEAFYEYDGKPGLYSGSQHLGIKLKTNEIPKKIKPFQMSHEKEAEVSKQIADMFLTVEFRGINKLIEQQSHVIPRIDRITEEAAGKRYYTSFDLKAGFHQIPLDDSGRKIAAFVTHEGVFQYKVMPMGLTGSPDKCAYDEETHLKNIYEIICRIKSYNSKINIAKCQSSRPSAKYLGFILNKKGIHPNPDKTIFTDTSTQGLGAALVQQDRPIAFASRSLKPAEKNYSIIKLEVFGLVYALKQFRPYIYGKHTVVITDHKPLLALLKNKELTGILQRYQMTIMEYDLTIQYIKGEANNIADYLSRESFMAIDAKENLYEEVFPPKTYPPYYTDKFINYYNDKEKEIIPSDGKVQTPTGIRIYVPELLREKLLSVDNEYVFVMVDEYNKYVVATCCKKQNGPTLLHILLKCSSLLRFPKMPRSDNGPAFIAKTVTDYLKSVGVEQQFSSPHNHKSNAYVERFNRTLRSAIRIYKNQPLTMVVPHFVYTYNRAKSLSTGLSLAQRVVNTPDRSVSDENIHNGYSGIHELIKNTKSQFEQDKIDRKGLQLNPGDLVLRRVMHRKDAKTSHKNQPIWEGPFKVLQHLYGDTYEIEDTRKHRKTRLAIEKIHSDRLKKYIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BND0</accession>
    <name>A0A0N5BND0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoporin NUP214</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BND0"/>
    <dbReference type="STRING" id="174720.A0A0N5BND0"/>
    <dbReference type="WBParaSite" id="SPAL_0000740900.1">
        <property type="protein sequence ID" value="SPAL_0000740900.1"/>
        <property type="gene ID" value="SPAL_0000740900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000740900.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="86031" checksum="DC2BC97C981919C4" modified="2015-12-09" version="1">MKKNKVSAAETYYFDTKSRFDESEVRLEKVRENFTALTKAIELLNKKIESKGLMNNIAKLDDANVIGSEDQEYIQKVSRNIVRATNIAFRKLKLLNDKYAELKNLKEKKNQDEVSRSFLNQSTILDNSFILEKTYIGETENLFTTNINRNKDFQNYLRKRCSKPVEKKFVKTLPFMQNVVIKKDEIDVESTVKNVKNMLEKCLIVSRTVNSSFSENSGIDVYLTKEDVTKIRQDTLNEAKEYAADFKATLEMTRKLMAAEMPKIDFNPPKEDIKEQKKVEGNGALPQKSIDRYAKPVEINKTANVFPNKQECIEKKNEVVNKTPTKVEESKITTEKNVELTGEVNADNSLSTKKDNETASLTKEVSNESTKGLFLGESDQDKNSTKSTISDSVNSPTLSTKSVFTSDKDSDSTTPRKTVFSENSGNLETPKSPLLSNTSTTTDTPKSLLFENVSTPKNNENSPSSIFGGSTKTPTQQGSFFGGTGTTTTPTKSSIFGGSPATPKQSVFGQSSFGGSQASGQSPFGGSQASGQSAFGGSQTSGQSAFGGSQASGQSAFGGSQTPGQSVFGGSKQSTPSVFGGSQQPTTSAFGGSQQSGQSVFGGSQQSGQSVFGGSQQTGQSVFGGSQSKSVFGGSAFGGSFGNTTTKPSQPNGGVDDGSNISTGFFSGMSGLGSQVSEKKNVFAQSAFGASNNAPKESSAFSFAKPPQTNAFQQNSNAPKPGFFSSNSSSSFGSSNTAFAKPAFGGSSTGSFGTPANTSTFGKSAFGQSSFGQSSFSSFANKTGSGFGGLSNSQQQSTFGNSSTTNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNL0</accession>
    <name>A0A0N5BNL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNL0"/>
    <dbReference type="WBParaSite" id="SPAL_0000748800.1">
        <property type="protein sequence ID" value="SPAL_0000748800.1"/>
        <property type="gene ID" value="SPAL_0000748800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000748800.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14539" checksum="41C7D0842A18642C" modified="2015-12-09" version="1">MKNKKSKNISSETLISSETSDYTSDNITSMVNNLNIGDTLKIDIRMEKVGYDLIVKESSSKINKAEPQNTSYANETKSQQTCPYGEIEELLNVENILDTESLTQMVKEASDIFERYKAEEECITTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP40</accession>
    <name>A0A0N5BP40_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP40"/>
    <dbReference type="STRING" id="174720.A0A0N5BP40"/>
    <dbReference type="WBParaSite" id="SPAL_0000766600.1">
        <property type="protein sequence ID" value="SPAL_0000766600.1"/>
        <property type="gene ID" value="SPAL_0000766600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="603"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000766600.1"/>
        </source>
    </evidence>
    <sequence length="881" mass="102548" checksum="4427006AFEAB3635" modified="2015-12-09" version="1">MIIGSEVIHASEMIIDYKNLSLFVCDRPLKHLSVTKNETKTNNVVASMSIVDDFQLKEIEDLKNEFYDVISFDKNRIGLSKLMAPTLKVVDSNLPKLPRYFLPSHQIPIVEEQISQWLNSGTIKEDFYVKYLQNLVCTRKKDGTWRVCLNCKPLNSKLQDYYYPSPTLKQIIPILSNGDWYTCLDLCQFFTQIGLDDESSQYLGFVALNGKTYKFTRLIYGLKPASSIAQRLINEVTHKFKNVVAYIDDLIVTTRGSFSQHIQDVRNLLIELREMNLVLNGPKCQFACKQVEYLGFKFDSNGMSISDHTTKAMKEYPDIDTHSKMHRFVGKVNYIRYFIPRLAELQKPLDEMIARPKSQFRYTSECQNAFRKIINSIVNATKLQLPDTSRPFTLVTDASHDCYAGILLQESPQHNNKLMPICYFSKRSPAKKKKVPALYMELKAIVKACQYFHQWIINTPTVVLTDHKPLLYVIKDNLDHKLYSYINELNIYNLTIKYIKGSKNILADTLSRAYINRISISENAETLKLQKFDNLSDEQKKEYFKQLHDDMAHLSYHKTYPLLRRRYNWKNIAKEYREYCEKCKVCLERDSPHAGKFKMTSISSSFPMERLTMDVCGPFRKSLSGNVHYLAAIDTLSRYLFTCPIPDTKTDSIIKALQEIIYRAGSPMYLKSDRAKYFESEKLAEFAKDHSIILEKGTAYKHTSQSLVERSFRTLHQLMSKSIEEQNYNKWDELLPKLTFIYNSSIHPISGRAPHDIFHGWSPRLPKDSHTSTDPRNLVDYEETTLQRLASFKIAKEMMVRIREQLSDQEEKEPTRLSTLTPGCKVYIKRPVTRTMLSQKHIKEWQPGFFLRRREGDTCIVSSKKGRQFKLHVDRVKEDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ41</accession>
    <name>A0A0N5BQ41_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RT_RNaseH_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ41"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ41"/>
    <dbReference type="WBParaSite" id="SPAL_0000801200.1">
        <property type="protein sequence ID" value="SPAL_0000801200.1"/>
        <property type="gene ID" value="SPAL_0000801200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000801200.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36849" checksum="9F78078D2685BFA7" modified="2015-12-09" version="1">MRIEYPGFIISKQGIPPNPKKTKVLADKEIFKNEKELRFFLGAAIYYRKHITNYSKIASILYEATKNFIWNDHHTTAFNNLKTAIINACTLSLPDSIALYAIMIDASIQGLGAALIQDNKPIAFTSRTLKKSEVMYAPVQLEAIGLVYALKQLTPYIFGKRTTILTDQSSLLSLMTKRDVSNILDRHKTYIMGFDLDIKYIKGTDNSVADYLSRKIFSIDITSTTANFTDAFPKLTNYLQLPYVVDNFKKYLSDKERELYPEGTISSRGKLRFFVHQKLRFMLLTVWYEHPLLGNHSGFDKGAPKIKDVFLLPNMDTDIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ87</accession>
    <name>A0A0N5BQ87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ87"/>
    <dbReference type="WBParaSite" id="SPAL_0000805600.1">
        <property type="protein sequence ID" value="SPAL_0000805600.1"/>
        <property type="gene ID" value="SPAL_0000805600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894704" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000805600.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11222" checksum="59A43223C5714362" modified="2015-12-09" version="1">MNSFAIIIFILTIPTLSSGFFTYNCEQYNNKTCEILLTPFDDLFKNVFLPTLDALTQFSVNFGITGYENDPKTILGQVNDDLKEVNQTTIASIYCYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQL1</accession>
    <name>A0A0N5BQL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000817400.1">
        <property type="protein sequence ID" value="SPAL_0000817400.1"/>
        <property type="gene ID" value="SPAL_0000817400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000817400.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="44041" checksum="0E3B4ECCB8D26601" modified="2015-12-09" version="1">MKAKISSGVSDREHEMYLSAIKKALPQHNKLLVTIDGTRKYLKKRSISLSNEAIYQEFTDGKFVIYNARRRIDEIFRMYAEEIVSYTEETLSSPHLKDTISGKIYRMMNNVNKDNFLIGLQLHFDGGNFNKTNKDYQIFLFSLRILNLPPGIRNKFELYIPLAIYYGIGKPPFELMEEAIIQSFKKFKLFEKDSTVVNGKEICYNVRVINFTADIIAKTDFLRMKHFKQMYGCSLCLTASTTLMKRAVYPSAMGCTLRTRNSMIDDVNYVLRNRYIIDNYHGHKENLPMFFDDIMYPYVITVDWFHSVLYRVFQNDMRNMLISGFYINNEEFIVSPLSDGSKEMIDYKIDNNKISRCFTRKLRKLECFGPYKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU56</accession>
    <name>A0A0N5BU56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU56"/>
    <dbReference type="WBParaSite" id="SPAL_0000937875.1">
        <property type="protein sequence ID" value="SPAL_0000937875.1"/>
        <property type="gene ID" value="SPAL_0000937875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000937875.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42698" checksum="768ADECC0B11ADF6" modified="2015-12-09" version="1">MDFIEYSFHIFNLTFGVLSNIIAIYITHPLNSKKGKCQVNILMIIQFIINIITSILSSTTGISTFIYDNHTFVILIFLKWLPYNFLLWRVIYIIILILIYVTIIFPVGILAIKCIVLVKNLKITGSWLFLVTLCCFLVNLLVGHAAYTISSEEIPNDIFVKFINTLSSEQIPNDIFVKFINTFKINSNLFSKDSMNIKNLIVPIIDLILYFVAVIIVIFVSLYKYLSYIKTFPMSERTKKLHIQFLKVNLLQSCIPFIITIPLPIIFYIFASVDCAYYNFLFGEIMLKLLCIIPTVNAITYIFLPSVNRMKFFSIFILNRNKLINLKAHSLSFIEPVQENNNQHLKTKKNRVIPFPLQGSRRISKISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUN8</accession>
    <name>A0A0N5BUN8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHC_N2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUN8"/>
    <dbReference type="WBParaSite" id="SPAL_0000955800.1">
        <property type="protein sequence ID" value="SPAL_0000955800.1"/>
        <property type="gene ID" value="SPAL_0000955800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000955800.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8894" checksum="C5C3388F44D2A24F" modified="2015-12-09" version="1">MRHLSFSITDNAEDELVNLWRRGMEELFLPQLVKNYTPARKFHNTIFNDILYREEQLDEAQQILVDPYAQIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV14</accession>
    <name>A0A0N5BV14_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV14"/>
    <dbReference type="STRING" id="174720.A0A0N5BV14"/>
    <dbReference type="WBParaSite" id="SPAL_0000968200.1">
        <property type="protein sequence ID" value="SPAL_0000968200.1"/>
        <property type="gene ID" value="SPAL_0000968200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000968200.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12603" checksum="54E974BC03B62632" modified="2015-12-09" version="1">MDNIIAMLPSWMTCFSTHMDFHGQQKAERIYEIIIVMSAIIGFFIGFFTQQISHMVFSIGFGFALSCIVVLPPWPCFRKHPVQWLPNVVPPKNEEVEDKPKDESEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVY1</accession>
    <name>A0A0N5BVY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000998700.1">
        <property type="protein sequence ID" value="SPAL_0000998700.1"/>
        <property type="gene ID" value="SPAL_0000998700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21749:SF6">
        <property type="entry name" value="ACTIVIN_RECP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21749">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895074" evidence="1">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000998700.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11859" checksum="DD1439F230B6295A" modified="2015-12-09" version="1">MYSRKYLLPCIFLVFLIHTSFSLTCYDDYLEGADPTTRKVSKCEKENCYRFTIKVDTSLVKTNTVVAGCSTYRCKLANTVNKCETKKLEGTTGEFCCCNTDRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW51</accession>
    <name>A0A0N5BW51_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW51"/>
    <dbReference type="STRING" id="174720.A0A0N5BW51"/>
    <dbReference type="WBParaSite" id="SPAL_0001005400.1">
        <property type="protein sequence ID" value="SPAL_0001005400.1"/>
        <property type="gene ID" value="SPAL_0001005400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="80"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001005400.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23980" checksum="C7263F2E0CA0F78B" modified="2015-12-09" version="1">MLLRYKMLYKNNLLVLEKQDTYWRIIIIEKVMENKSDAFDNIREKIKNKLVDYPDFPKKGILFKDIMPLFKDPGLINDLALAIATHFKKCNIDAIAACEARGFLFGVIVSIHMNVPFVPIRKKGKLPGECISATFTKEYGEDIFEVQKGSFKSGDRVLILDDLLATGGSMSAAISVVEKAGANPVNAFCLVELTELKGLDKLPKSTTFEAMIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWD7</accession>
    <name>A0A0N5BWD7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWD7"/>
    <dbReference type="STRING" id="174720.A0A0N5BWD7"/>
    <dbReference type="WBParaSite" id="SPAL_0001013400.1">
        <property type="protein sequence ID" value="SPAL_0001013400.1"/>
        <property type="gene ID" value="SPAL_0001013400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029153">
        <property type="entry name" value="CPG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053123">
        <property type="entry name" value="CPG4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37442:SF2">
        <property type="entry name" value="CHONDROITIN PROTEOGLYCAN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37442">
        <property type="entry name" value="F18A1.7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15481">
        <property type="entry name" value="CPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895233" evidence="1">
        <location>
            <begin position="18"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Chondroitin proteoglycan 4" evidence="2">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001013400.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36392" checksum="A15366E037E6878A" modified="2015-12-09" version="1">MLFSLLIINCFVFGSISFKLSPLDKRSFFDGENGGENTSGDLSINDIFSMDENVGTEEIYTGPDECLHYCNDEIIRIVKPAMSMSMKISEKYKTICEEYDSARMCMEKRPQCPSQKFFVTATSGVKYMCEEQKDAFDATIPCITDWFRYSNAECETLCMASNLINGISIKKIFQQDFKFLEAFDPYIAKISVNEMCRVAECMLSCYKQKLNTRCDGTAGSILAEVVLRPIADVQAVAGPISPIISSVLPLKCAFLHDPSIMNQLRIDERLSKEIAKKYRLQKELPQRNVEKNEILEVQDPFTYNISNDSPLNFYDDVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWM7</accession>
    <name>A0A0N5BWM7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWM7"/>
    <dbReference type="STRING" id="174720.A0A0N5BWM7"/>
    <dbReference type="WBParaSite" id="SPAL_0001022000.1">
        <property type="protein sequence ID" value="SPAL_0001022000.1"/>
        <property type="gene ID" value="SPAL_0001022000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001022000.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37508" checksum="0750CB65F1FB8AA5" modified="2015-12-09" version="1">MRPLLLKGHERALTRVRINLEGDLIFTSAKDRTLCVWFTDNGERLGTYDGHEGAVWDIDVTWDTRLLLSSSGDCTVKLWDVCTGKNLISMTNQVTTRSCAFSYSGNLAAYTTKKMQINPSILRVFDIRDPSHIIERQNYEEGSILFKKFKFDIDSESCIFSELDNVVTVGISNGTLEQYDIRNPTEAVNSTKEHQSNITDLQLSKDGNFLISSSTDKTAKVYHSRTLELLKSFRSGRPVNSAAISPTRDHIILGGGEEAMNVTQTSTNSGQFEARMYHLIYEQEFAKFKGHFGPINTLVFHPEGDIVITGGEDGYIRIQELDEKYKTFEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWS5</accession>
    <name>A0A0N5BWS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWS5"/>
    <dbReference type="STRING" id="174720.A0A0N5BWS5"/>
    <dbReference type="WBParaSite" id="SPAL_0001026500.1">
        <property type="protein sequence ID" value="SPAL_0001026500.1"/>
        <property type="gene ID" value="SPAL_0001026500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001026500.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15667" checksum="EB0075B38D17308C" modified="2015-12-09" version="1">MGYLKLSFTWHSIFSKLFSNVFKRKQQIKGVGLQDTTNEQKKSMNIQQLAKLSGSALLLSSKRTPMIKFNRKGPVLKFIPENFPISLVSSTVTPTSKNDFGQVGKTPRGSGIDESELPFRYRRSLIPEDECSIINNGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYV5</accession>
    <name>A0A0N5BYV5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BYV5"/>
    <dbReference type="WBParaSite" id="SPAL_0001095300.1">
        <property type="protein sequence ID" value="SPAL_0001095300.1"/>
        <property type="gene ID" value="SPAL_0001095300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31936">
        <property type="entry name" value="PROTEIN CBG18744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31936:SF7">
        <property type="entry name" value="SHK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001095300.1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="114355" checksum="71DBDC6D5851E8E7" modified="2015-12-09" version="1">XYNVQKTEEVTTVKSTVPTTEKDLTTTEESTLKYTMSSKLTTVVSTSNDIATETSTDSSTVIVSTLTPELSEIVTFTDVFKTSEELSTMLTSTLATTTSENISEIVISTLVTTTSEELTTIVTSTLTPTTTEEISTIVTSTPIPTTSEELTTIETSTLAPTTSEELTTIVTSIPTTSEELTTIVNSTPGPTTFEVITTIETSTLAPTTSEELTTIVTSIPTTSEELTTIVTSIPTTSEELTTIVNSTPGPTTSEDITTIETSTLAPTTSEELTTIVTSIPTTSEDITTIETSTLAPTTSEELTTIVNSTPGPTTSEDITTIETSTLAPTTSEELTTTVTSIPTTSEDISTIETSIPTTSEELTTIETSTLAPTTSEELTTIVTSIPTTSEDISTIESSTPTTSEELTTIVTSTSVPTTSEDISTIESSIPTTSEELTTIVTSTPVPTTSEDISTIETSTLFPTTSEELTTIVTSTLFPTTSEETTSISPLCDVKNGVWSSWKTIRECSDTCGSCGHTIKRRTCLSLQFNIPCLGDSEKVDRCNHKPCTFPRLSCCHGLKATVINKEIVCDSLPADEKPVLPSSCCPPGGIWGNWENWSSCNGNSCESCGKSTRTRECLTDSNKCPCQGDSSETKSCKYIGSWSEWSETIPCTDDCGQCGVRTLERKCLTTGTCACKGASKKTEICGFSPCVFPRDSCCNGIATVLSKQILCGPLPEPTIEEEPPCVSCCVVGGVWSEWVSEPCTDTCGSCGKQKKTRTCLSSPQCPCTGDSARSDPCNIEPCTFPRDSCCNGLSAMASTDGTNKIICGPQPIIFDPKPSTVCMPACCPKYGVWSEWSSQTSCDDTCGTSKRKQIRTCLSEGNGCPCVGSYTKEEYCSTIPCVFPRQSCNEGYKAMVINSNITCGPLPSLEVEEKKATLECNSMCCPKYGTWSEWQITKPCEDVCGSCSTETRSRTCLNEDECPCVGDKTQTYVCKTNPCVFPRDSCCGNYKAMVVNNELICGPLENIKEENPFVNSCDNTCCPNGGMWTDWYDVTVCGDTCGSYSNVTQSRLCISEYFGCSCTGNSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ75</accession>
    <name>A0A0N5BZ75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ75"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ75"/>
    <dbReference type="WBParaSite" id="SPAL_0001106900.1">
        <property type="protein sequence ID" value="SPAL_0001106900.1"/>
        <property type="gene ID" value="SPAL_0001106900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029978">
        <property type="entry name" value="LMO-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767:SF1">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="425"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001106900.1"/>
        </source>
    </evidence>
    <sequence length="1108" mass="125946" checksum="3248B342FF462F34" modified="2015-12-09" version="1">MNEGHRYDVMEATSVLRIHIYPDSTEEILTVVSPITVDTESYNNFGNKKKYNHFTSPSNTLSPDGSGNYYTDSGIDSSNFTSPQQIPEGFSPEKRRESSSIYFVPINPLQIPEEEEGEEDIISERTLSFPNLEDNKRIGDSYQLTRSQERTLESASTINSSEIDIPELGEGEEYNIEEESFHEDYQNVLLKEGTQTSQTLEKGEKQIVVVEAEASVSYLLKNTIQEAGIVEATVFPKAYASLQEKIKIYPITRKFQEVGFVPLYSLINYIRTNKSKELTSVPLYNIVDYIKHKKKIELEYSDIKDFVDIKEDNKISVTVEAAKENIGSVVAYRYPTSAQYIKIAYDINRKHNNSGSGVMLSSTGYNNTTNNLGKRTSIPLDEIYPSSKAFPQMNKHVYKQDIIRNNSITSVRSNAPDINGIIDIQMSVGKNYSTPSTGDSFGFYVRGGDKKKNESTLVVSHVKKDSPSDVCGLMVGDNIISINGVMLENLSLIKAERLYEESIKERNITIKIVREKKLKYGIKNEVVLLNKTPEIYDDNYFKRKGDYKISSSPQSDLGEELLEEEHNLHHHDNQQSHHSQSTAPAIDPIYRNSNKNDKRNGDILNIKTQQQHHNFQNSHSPSTSVINSTVLNFSPTSYTTSGVDSTHSFSPRSDSGASSSGGMSDYKVSRVESKKKDKIGKVIDFVPEVDRHHHRHPNTFKYSSNIDEIEQDYHAAGLTPIHDVDSQPKLIRNYNYNLIEKSSQSQDSSRPYGRREVTYLPPNRQISYEDDEIGEAGKDYISSNHHLETTQTLQRCPVVEMHPQYEKNNRTSKNYTNGRKDRTSGIRRSIERAGYNFTGEQSPPNGEEVDEDNESYVTVPSRVQSILKDKYDDDEDIYYDVKYSREDEDNYEGVKTAKNPYLKRQSPLVNDNKVILKPDEYILKDEESAISEGIVRYYDRDMQQIGRAYSYEESTTTSMTEDQDALRKLVRQQRLPAPGDPFSKNRLDADNRYENVSKSLEKQIKKHKQTIETPVKAVSGKKLCGHCDKTLGQGAAMIIESLKLQFHLSCFRCIECGIQLGNGTTGTDVRVRGRKLYCRECYHSAKFETGTENRISTTPSKMLNRIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZJ8</accession>
    <name>A0A0N5BZJ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZJ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001118900.1">
        <property type="protein sequence ID" value="SPAL_0001118900.1"/>
        <property type="gene ID" value="SPAL_0001118900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001118900.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="64052" checksum="B63626659D952EC0" modified="2015-12-09" version="1">MKSEENLSIIQVMKNDLVRKNILNMIPSIYDIYNLSMTSRQIASLIEGEIIKRNMMMYSDFQRITIKIKEGIRSKSNVYSLEDIEFEKDEYSCETLNEVNQFIGETIHQDNRISFIICNFVDKIKKREQLLFIKKLIRKMNLNMELRKNSTILNLWVDFSCDHYMILHALSFMNHENIRRIELSQNVFLSNYCSSDNNKNLNTTLFDGFPKFHELLIYGSLAVDNYNNLIENKNIIDVVLKELSSRKNATLILKLSDWGYHEIAQYIHMVLEIADKYDIKVKYDGDFISLLLCTKNNCLDIVEESINFPIKDFIFSVSITIENVKFFINCMKNLQHFKNLETLELKFMLFDIQKDFRKMNRLKLTYLSLQSCGKLKNVKFDFSDYLTEEDTSKIEIFKNNLENISSLMPNSIERVTIFNGFDLCKETTNIINKFMGDIKVLVVDGVSYKDEDCLNIFKNLRTFISFQNLPIQIPNTVDFLFIAHRDSWINTKENSMDKELLTTYSKKFSKKLQYLDDEYIFFNDIKKWNIYKKLFQEIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZT3</accession>
    <name>A0A0N5BZT3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZT3"/>
    <dbReference type="STRING" id="174720.A0A0N5BZT3"/>
    <dbReference type="WBParaSite" id="SPAL_0001127300.1">
        <property type="protein sequence ID" value="SPAL_0001127300.1"/>
        <property type="gene ID" value="SPAL_0001127300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001127300.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22483" checksum="1011B802DF6BFEF6" modified="2015-12-09" version="1">MSSGNENKENDTESKIIYPEDLISVEKEIRNLSFKRLRSVCKRNDIHLIAKKEILQNLLLEKLYEKQMEEYSQSAEEFAQALEGFTKMSNHEFPFAIKKFTPVATWSYNVENGTCSICRQDFTELCISCVVKEEKLKASGCKDKQQINCKIESSLGCIHVFHECCIASWIKRSPKCPLCQETWRKGYYFDNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C070</accession>
    <name>A0A0N5C070_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C070"/>
    <dbReference type="STRING" id="174720.A0A0N5C070"/>
    <dbReference type="WBParaSite" id="SPAL_0001140100.1">
        <property type="protein sequence ID" value="SPAL_0001140100.1"/>
        <property type="gene ID" value="SPAL_0001140100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001140100.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18645" checksum="D6BFD48B24214804" modified="2015-12-09" version="1">MFMVIVISILSLNRYYFYFALENAVCNNYITEKYWKRFTFDSVPIVLNRTIYTDVDIPNSSFIAIDDFKTSKQMTDYLHYFIKNPSEYLKYFEYRKENITVVPDSENDLNNGFCALCSKIRHHIEDNKVIEHVNPIYEDINKCIPKKAMLDFANNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0A6</accession>
    <name>A0A0N5C0A6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0A6"/>
    <dbReference type="WBParaSite" id="SPAL_0001143500.1">
        <property type="protein sequence ID" value="SPAL_0001143500.1"/>
        <property type="gene ID" value="SPAL_0001143500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001143500.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12418" checksum="3D071E087E991E7A" modified="2015-12-09" version="1">MFVKSSFIFIFCTFFYCFKLQSTYLECSNICTLLLAIIHLKIKKCNGRFDYIFGILLLIMIPKELPRIFGNKVAPTVETINQCMDISCLCTIDHNSFENQEIQWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0K1</accession>
    <name>A0A0N5C0K1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">START domain-containing protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PCTP-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">StAR-related lipid transfer protein 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0K1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0K1"/>
    <dbReference type="WBParaSite" id="SPAL_0001152900.1">
        <property type="protein sequence ID" value="SPAL_0001152900.1"/>
        <property type="gene ID" value="SPAL_0001152900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08871">
        <property type="entry name" value="START_STARD10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000008">
        <property type="entry name" value="START domain containing 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041951">
        <property type="entry name" value="STARD10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="17">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001152900.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33462" checksum="CFBF1EA34DE771A8" modified="2015-12-09" version="1">MSTVGTNNNFNTAKKSYKEQVVSKEEVRILEDNDFEKIRNLCQDNENWKCVYDNKNSKVWTLEVSDSDFLMYRVSTVFEDIKADIVYDVLHDPVYRKKWDKYMIDSKDIGMINPNTDACYYAVGCMPPFKSRDFVMQRSWLDMGNEKFICSHSICHKDYPPFPKFIRASVFLTAYQIVQLESGCKITYVTHSDPRGKLPIWFVNRLTKIVAPGMIKKLHKYCLSYTNWKAKHQEHFKPWRFPEQMLGLPKINLADCEPHIYDDALNIIDESNVNDIEKDLDSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0V0</accession>
    <name>A0A0N5C0V0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0V0"/>
    <dbReference type="WBParaSite" id="SPAL_0001162900.1">
        <property type="protein sequence ID" value="SPAL_0001162900.1"/>
        <property type="gene ID" value="SPAL_0001162900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="499"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="1022"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1292"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1292"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001162900.1"/>
        </source>
    </evidence>
    <sequence length="1311" mass="150320" checksum="FE1A16DFEF3A7257" modified="2015-12-09" version="1">MANIGQAWLSVKVYSESDGDLKQYIKRLERLWIVDGLTMDIKKKNALLAMMPESIVEYYEAVAEDDDSYDVAKEKILKKFDGSQSVIVAHNKLKVFKLDWREDKFEASLLEYGQLLKITAQSLNGEELLAHQISQVTQLVSSEEELFRRLLYKNDYSTYKELVSDLHTTLMGCRRMRAGRSILRSSNNLDGKGGYRFKGQCFWCNERGHRESDCKKKALGFPKVINGKDSGKENVKFMNTGYGSNNSSKGTTSAVKEFHDDDDVAGRSHLAIVKMKFKSNGDELNDRVIVPVMLDTGSTVNLVKDSVINNLGYRNKVKNNSVKLSSAFGDIYQAKGCVSMDIEYDGVKRCDDFLIVDDKCFKSNEGLYDAILGVCTMRDIGLDKFMKVLCKLDDKEEPVKMIAQQIQRNSQYYIPDELFLPVEDEIHELANDDKDLPDDVVQLWHEYKDIVSESEYDLGACSIEVPRKVLNGKEFVRPPRFRYNPVQEKELIKLVKELLYSGILVKKETTFVSNFIMVPSKDGIAPPRFAVDLRNLNSCTRIDSYPTKTASELYGYLQEALFYTSIDIAKSFWQLRLHEDDQMYYGVYTPLGTCCFTRVPFGDVNAMPYWQRIYDRIIREAIGDHGISYVDDLVVYSNSSREQHLELVRRMFDTLRKYNLKIRKKKTMVAQNSIKFLGWIISPQGRVPAKSNTEALKSRKIPKDVKDVKKFLGVVGFFRDAIPQFSRIALPLTEMTKDKNKDKFIWSQEADKSFKELIKLVTNPPILKIPEYHKPFHVYCDSSMLAMGAFIGQVDGSGKLRAVRYYSKKWSYVKREKTINLLELQAIAVTLQENVDILGLGKIYLYTDSKVAKAIIESSVDPMFARYVSYIQAYNIVVVKIKGENNCIADDLSRSVCGVGVLDDHCSDDVFPLPNELFIKKQKEDEFVMKLIADNKLVFLNGVAYKKVLRKEGEESKEILLPIMPRQLVQNYLKAIHDEFGHQGVNKLLLMVRKAYTWENQDRDIAEYVKLCKICQQTKGVQDKHPQFQAIDYPLVPWSVISWDVMGPVKPWKLYVVNVVDNQSSETLISGLLNVFSMFGLPRVIRSDNQASLKSQEVVNLMKKLNVRMEHGIPFHKEGNSLVERSFKTMEEIMKREKLESRVNDLHGLVWRTAWLYNSYPNLTTQKSPYEVLFGRPPHLPQDAPKADVAQVEKGFENFYVQMKIGWEIASQKSKDVRESLNARLDNAGVEIKQYNVGDRVWVYRNLNKTEPQWVGPYTVVSQDGAEVLVRKSNKGRNLRTHVKDLKLVLEDPNSENEKGDGVTYSQENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0W1</accession>
    <name>A0A0N5C0W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0W1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001164000.1">
        <property type="protein sequence ID" value="SPAL_0001164000.1"/>
        <property type="gene ID" value="SPAL_0001164000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001164000.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15459" checksum="F68EB9AD20EED5D8" modified="2015-12-09" version="1">MDPNVINLRLPSTRTNSQNGQENDDNNSVFAHADGGNSRDHSPSHHSSRSNDGRSNVSAYASGREGMFSNEGVGGGPTGQHPNPQLNVGGGPTDRGRNTLPVVGGGPTDQRVNELPVVEGGSTGQRVNATVDESVTKCRKRFYTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5H6</accession>
    <name>A0A0N5C5H6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5H6"/>
    <dbReference type="WBParaSite" id="SPAL_0001320500.1">
        <property type="protein sequence ID" value="SPAL_0001320500.1"/>
        <property type="gene ID" value="SPAL_0001320500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001320500.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25062" checksum="FF6E60EF5D96BBC5" modified="2015-12-09" version="1">MYLKTIFISYIHFFFTLICHRIKYILTTNMAFKDLRFSKNQLDSAGTFYELMLLILKNKGMTDSNKDTTIESECKTELLSKLDLEVLKEIREDIQKSLEDSTTKEIMTSFKKLYMREDPDALRIINLFKNLNEKTSDLEFLKRETKMLEGLLSNLNGKQVAGLYALLKWDAPCGAEAAILSRIVSSEKVNTGDEMIHMIQSITAMTVTANITKTTTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5U4</accession>
    <name>A0A0N5C5U4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nonstructural protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001332000.1">
        <property type="protein sequence ID" value="SPAL_0001332000.1"/>
        <property type="gene ID" value="SPAL_0001332000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001332000.1"/>
        </source>
    </evidence>
    <sequence length="40" mass="4626" checksum="EAA601E7CE5E2472" modified="2015-12-09" version="1">XAMFCGRNERKVVYSEDNVVVMKYVGSTPSSSIRIKYHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C630</accession>
    <name>A0A0N5C630_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C630"/>
    <dbReference type="WBParaSite" id="SPAL_0001340500.1">
        <property type="protein sequence ID" value="SPAL_0001340500.1"/>
        <property type="gene ID" value="SPAL_0001340500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340500.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21194" checksum="ACA617861D4160FF" modified="2015-12-09" version="1">MSENSGSNGNKPLYPQFPQYFTTNATEHYSKIEEREENKQIVTQEHTVHFQKMPVIQQGDKKTTNKINFISDSNREQETQHLKINNTIYHQLSGTQKITNESTKPDEKTSTKDENLYKTLFHHLAESDQLMAKKNEIINFVGNRLLEEALLLLSNGNNEALMQKFSKIHEKEFYSFIASCYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6F2</accession>
    <name>A0A0N5C6F2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6F2"/>
    <dbReference type="STRING" id="174720.A0A0N5C6F2"/>
    <dbReference type="WBParaSite" id="SPAL_0001352100.1">
        <property type="protein sequence ID" value="SPAL_0001352100.1"/>
        <property type="gene ID" value="SPAL_0001352100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF38">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001352100.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27433" checksum="C56F962325B09617" modified="2015-12-09" version="1">MSKEDHERQLETNLRNLALNGFPSYKKSTTNSKDYLLKRYTRATAINKTDPLQDYEGHHHEGFFNVFKPSAFLNVVGIPVVYEAIVLSPHAFISEILNPEFGIVNVLSPRAFVATILSPNALLSRILQPGFFRAEVLTPRALNSWVLSPDAFIAEVLSPKFLEAKILSPELFAIQVLSPRFITASVASGEIFAIHVLSPSILSPSVLGKNGMIVEVLSPHLLSGDHNDEHEEDHDKQKETNSTTFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C705</accession>
    <name>A0A0N5C705_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Craniofacial development protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Bucentaur</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C705"/>
    <dbReference type="STRING" id="174720.A0A0N5C705"/>
    <dbReference type="WBParaSite" id="SPAL_0001372000.1">
        <property type="protein sequence ID" value="SPAL_0001372000.1"/>
        <property type="gene ID" value="SPAL_0001372000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="109"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001372000.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21622" checksum="46E4404F47DA9C82" modified="2015-12-09" version="1">MDKEFVDDNNCEDEEDVDYTPESDPEEDVSDKEEDFDEDLKIEKLKNTSEENEEEKKVDSGSEDDDEIYNQLLNAGNTKCKVTTKISENTTESKNKSTKEDSIPTNKRSAKSSGLLDIAESMKKRKTTSISQCTESWKKYVTSTGISEELASFNKGKGGFLARQDFLAKTDLRQFEKEKDARNALRKTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C722</accession>
    <name>A0A0N5C722_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C722"/>
    <dbReference type="WBParaSite" id="SPAL_0001373700.1">
        <property type="protein sequence ID" value="SPAL_0001373700.1"/>
        <property type="gene ID" value="SPAL_0001373700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001373700.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11541" checksum="1C037C9DD6C2B200" modified="2015-12-09" version="1">MKVELTSMNSDNSLNSSLASVTNSNIRKRYEKPIKEVGKTFYCNTCKQTTSEREKVWFNLLVILLYLGFFFVTLLGISLIFRKPLCYILHGLLQYYTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7F0</accession>
    <name>A0A0N5C7F0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7F0"/>
    <dbReference type="WBParaSite" id="SPAL_0001386400.1">
        <property type="protein sequence ID" value="SPAL_0001386400.1"/>
        <property type="gene ID" value="SPAL_0001386400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF6">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001386400.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58098" checksum="4A1CD81B20316E04" modified="2015-12-09" version="1">MDEENVSLDQSSGQLSRADERVLLNTKMAFSLKKLKLNVEPTLVILSFCVGILITVVPLFIFWGRCVEVADQYSPVPVPKNIENSTLRCANIFTKNETFLRNSIEKDIAEMKIYMQLVGGIPTLITSPILGLWSDVYGGRKKVLTITSLGLVIYSCLQLYATIYYDKINIWYPLMIAEFLMGCFGGIATIFTSGIAILIDDSREEMNDGGIPMRIAITTAIQSLFLLIGNYLASYFMVPATVSITQHINSYIILISISFISSIVIFLYTIIFVKTHTVEINNNNNNESIRIWQTLGSVFSGLFDVLTMPRRGYLRCVINITMFLVLVDCMTSDPSLFVLLLKGSPFYWPDVNFTYYIMLKTATGCIGMTVIPIILSYFNIHGKDSILLLIGFIGATTIAFLTAFAGTNFLIFLTSGLYFFAAVTQPGFRTFLPKLVGEDQTARLFTLISLLYVIAPIISSSILNTIYERTFIEWSGFVFVLIGIINCFGVIGQFINHYLLLPIWKEDTVNYSILQNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7J2</accession>
    <name>A0A0N5C7J2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7J2"/>
    <dbReference type="STRING" id="174720.A0A0N5C7J2"/>
    <dbReference type="WBParaSite" id="SPAL_0001390500.1">
        <property type="protein sequence ID" value="SPAL_0001390500.1"/>
        <property type="gene ID" value="SPAL_0001390500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001390500.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28065" checksum="74BC7F35C49C35B9" modified="2015-12-09" version="1">MFVCGRQGISKIVRLSKFIGSTSKSVKFQGSTNFFSTSAKKENGDEATKDLKFSIKCKDDKRLTFDKYLEHVKNTLAVKEGEELKAPEGALKTIGEEYDILMSEVSELKDKYLRSVAETENVRKRGVRLVDDAKVYAIQGFCKDLLEVADILNLAIDAVPKEDVESDKKLKDLYDGIVMTKEVLLKTFNKHGLVPVNPDGQKFDPNLHEAVFQVPKEQANVPADHVAHVAKIGYSLHGRPIRPAQVGVVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7U1</accession>
    <name>A0A0N5C7U1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7U1"/>
    <dbReference type="WBParaSite" id="SPAL_0001400300.1">
        <property type="protein sequence ID" value="SPAL_0001400300.1"/>
        <property type="gene ID" value="SPAL_0001400300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895600" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001400300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="17073" checksum="16E98FFCADA49EB6" modified="2015-12-09" version="1">MILKNIIIILFIILFNIIDVENHLCKRRRPKLRVWGRIDCRNRLAKDMRIGLYQFNRFKYPKLLKEVPCRCEKYFDIRAEEISHSRTMPYLAVTYKYINGRFLCKPRAIVRLPKSYDNSPYKCVKIPIKIMLNKHKLGFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8C0</accession>
    <name>A0A0N5C8C0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Clat_adaptor_s domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8C0"/>
    <dbReference type="STRING" id="174720.A0A0N5C8C0"/>
    <dbReference type="WBParaSite" id="SPAL_0001417100.1">
        <property type="protein sequence ID" value="SPAL_0001417100.1"/>
        <property type="gene ID" value="SPAL_0001417100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001417100.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21927" checksum="7AA23D1082653CC9" modified="2015-12-09" version="1">MIKAILVFNNHGKPRLLKFYSNYSEDEQQQIVRETFQLVSKRDDNVCNFLEGGLLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLVFHVDKVHNILSELVMGGMVLETNMNEILTRVQEQEKFEKQEAGISAAPARAVSAIKNINVSQQIKDLKLPDLPSLTNFKNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8R6</accession>
    <name>A0A0N5C8R6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8R6"/>
    <dbReference type="WBParaSite" id="SPAL_0001430700.1">
        <property type="protein sequence ID" value="SPAL_0001430700.1"/>
        <property type="gene ID" value="SPAL_0001430700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019423">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srj"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907:SF16">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001430700.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="40068" checksum="9CC92BED1323B6DE" modified="2015-12-09" version="1">MDVPFFGPDYLITIRKLLSINDLVGTILGATVNFILLYVLYKMDKHEISNYKRIIILVTLTDFFLSLSNSVAMLSMETFNGYILTFTEGITFLISSKIWTYSCIFFHMVLFQLSFCNICITFFYRYLLLIHNYKMTNLQFFSTIICLIIWNSSSLVVLSFCIIPSDDPEYKKLINLFEIPYKNELKEYEREIIIINIFVIYGLIYNIQLFSTSSICVLIVYFSYYKIRKQLQLQKNSMSSKSISLQKQLNRVMFCHALVPMFLGFIPVLIFEASDYFQFNIKGLGTLLFFSIEWVPFVSGLISLTMINACRNKFLTIIRLRNYISPHVVPLQQYTLVYSKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Z0</accession>
    <name>A0A0N5C8Z0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Z0"/>
    <dbReference type="STRING" id="174720.A0A0N5C8Z0"/>
    <dbReference type="WBParaSite" id="SPAL_0001437300.1">
        <property type="protein sequence ID" value="SPAL_0001437300.1"/>
        <property type="gene ID" value="SPAL_0001437300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000147">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF451">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="934"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="973"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001437300.1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128233" checksum="45F4DF5C8C19B4F8" modified="2015-12-09" version="1">MSDSNFEIDVKDLRSLMELRGNEALEVINKKYGGIENLCKKLKTDSMNGLPNDPNEIERRRKFFGKNEIPPVPSKSFLKLVWEALQDITLIILLASAVVSLVLSFWKPPHEVSGGDPNDAEVEWIEGVAILIAVVVVVLVTALNDWSKEKQFRGLQSKIETEHKFSVIRGGEAMDVTVHDLVVSDVIRVKYGDLLPADGILIQSNDLKIDESSLTGESDLIKKSPETDPILLSGTHAMEGSGRMVLTAVGVNSQTGIIMALLGASGKDKKDDDEKNVPHSENLSNIKVPALSGSDIEVKKKKDSNASINEDAVSKHKSVLQGKLSALAIQIGYIGSIVAAATVVILVVRHCITHYWINQEQFKLSDLSYFVSYIIVGVTVLVIAVPEGLPLAITLALTYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQSYINEKFYKNDPPKWNLLHDKTKDLLVNCISINSGYNSQVIEGKVGEPRTQVGNKTECALLGFVLDLGQSYDLIRKNKPEDQLFKVYTFNSQRKSMMTVINLPDNKGFRVFAKGASEIILSRCKYILGNNGELKHFGQNELIDMTTNVIEPMASDGLRTIGLAYKDYVYENGNENEVVIDGTIDWDDEETIREGMTAIAIIGIQDPVRPEVPAAIEKCQKAGITIRMVTGDNINTARSIATSCGILKPGEDFLALEGKEFNAKIRDANGKVSQEKLDAIWPRLRVLARAQPSDKYVLVKGIIDSKYTKNREVVAVTGDGTNDAPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVTIAFIGACTVNDSPLKAVQMLWVNLIMDTLASLALATEYPTEDLLERKPYGRTKSLISRTMVKNIVGHAVYQLAILFCLLFFADQFIPGVTNGREAPLGSPPSKHFTVIFNTFVLMTLFNEMNSRKIHNERNIFKGIFTNPIFCTIWIVTFISQILIIQFGGYWFSTAPLDIIQWSICLGFGLSELIWGQVISTIPSTILPKSFSFGRGEVRPTSILVTGEYDATDERIPQIGDDKVSSLSQARPGQILWLLGLTRLQTQMRVVKAFQSNINSSHPSSLTTSASERIRNSFRRLRIAKERELAKASRAGGQVNVEEPEKNSTHIKLTVPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C900</accession>
    <name>A0A0N5C900_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C900"/>
    <dbReference type="WBParaSite" id="SPAL_0001438300.1">
        <property type="protein sequence ID" value="SPAL_0001438300.1"/>
        <property type="gene ID" value="SPAL_0001438300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001438300.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="57941" checksum="E2A9864CB9B8BA96" modified="2015-12-09" version="1">MLTSSIAGSVLLPTSLPLDASNFDQSDYSLFVAFGFVIAFILAFAIGANDTANSFGTSVGSKALTLIQAYILASIFESLGAALLGYKVTDTMRKGVVDVKVYENEPGLLLIGQIGILAGCGIWLLLATVFNAPVSTTHSIVGATLGFSIAFKGFVGINWYKIIKIIVSWFISPVLSGLTSLGISYGLKYFYQCFDKPYVAAIKSLPFLLIGTISLNVFAILFEGPELLGINELSGGKILILSCIVGILGYIIFYFVEKCYLKQMYDDILNGKTILKKNMEKNERDSVPERKTSDSKNAFSTDILSTDENISTKKNFSLNHKNCGNIRSNEECCEISDLKLDDNFKKEEGIIYIPVNNSLEEREEIVMGKVFSILQVLTACFGGFAHGGNDVSNAIAPIVSMFSIWRDGNVHQVEGTPIYLLIFGAVGMCVGLWVLGHRVIYTVGNNLTEITPIKGFSIEFGAAGTVLIASKIGIPISSTQCKVGSIMFVGVFDKSSKLDWSLLRSITISWIVTLPFTGFFSGFVAIILQWLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9B6</accession>
    <name>A0A0N5C9B6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YccV-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9B6"/>
    <dbReference type="WBParaSite" id="SPAL_0001449900.1">
        <property type="protein sequence ID" value="SPAL_0001449900.1"/>
        <property type="gene ID" value="SPAL_0001449900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001449900.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="78890" checksum="6B2AEF0B5943F218" modified="2015-12-09" version="1">MNNNGHLTFEFDKLEEYKTEQKEYINIKFDKIKILYLSLDGINDGTSPCGLEINRYYAGGYEISYSAGYYVGNNFDFLLPLWCKIQQYEFGLVFFDRKKRADDLNNVNEVHTVEHAVLITIKSSNNKMLLGTRRHHKVNIIIGLCPYINWVNKKRWIEFIPEDHIKDNGFFEEENGYAHIVVPYYKKNYNAEEFICGKLKQPTLPDLLIGYKLEEDDRNINIAGEINPLNEEIKCQSSDNPQHHYHFGYLETDTNYMSERIMDAMEIRNKDSKHKFYAGQIIYIYKWDSISDILRNPSIHVRIDNADVTKEASCIKNLKSDIKANILPTIGSVDSIQKHQRKNIFYRLIKLDDLYQNFIFRCLSKVEGRNKVHMDEFYSRAAEYSIKNEEKPNIIYTSSKNQITFDRDNIDNYGSYRCKESKTTKFFNKNVITMDKVYYLPDEGSELSLGDLKNNNKQYIGCIKQYESLGEIKKIRIEFGENVRKPIDIDNFSKTTDKIDIKENLVTYKAPKDVPGVIVTCIYQTPAETTFYTKRQISFVIRGGTKTKNIAIINTNKDKTVDEYVDNSTPWIAAIVATVVLSCIVVIMVAYLVVKRTKKIKIGNGSSSSISYSGSSSLSKSNSKGSSGMNGNKKTATGKPKNALNLIVIKMNKNGNDSKTSTSSSNVTGNSASTNLGKNHFKNVKFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAE1</accession>
    <name>A0A0N5CAE1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAE1"/>
    <dbReference type="STRING" id="174720.A0A0N5CAE1"/>
    <dbReference type="WBParaSite" id="SPAL_0001486300.1">
        <property type="protein sequence ID" value="SPAL_0001486300.1"/>
        <property type="gene ID" value="SPAL_0001486300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001486300.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14860" checksum="A3138438C9D806BD" modified="2015-12-09" version="1">MVCVKYVKYLISNGLKESDIGIITPYSAQKIKIEKYLNGYNIEVSTVDRFQRQQKEVIIFCFVRDNKTKDVGLLIKKKYMIVAMTSARRQFVFIGNTNMLFTDDKFEELRNILLNEGISIDAGRYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAX3</accession>
    <name>A0A0N5CAX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAX3"/>
    <dbReference type="STRING" id="174720.A0A0N5CAX3"/>
    <dbReference type="WBParaSite" id="SPAL_0001503900.1">
        <property type="protein sequence ID" value="SPAL_0001503900.1"/>
        <property type="gene ID" value="SPAL_0001503900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001503900.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10817" checksum="A8FD6348929E24FE" modified="2015-12-09" version="1">MPSRHTISNKVRKRPGLDLDQVQKNLLPEKREKLENQPFDEDLPGGGQHYCVPCDKHCASAKDKEKHMKGKSHKQRVKELAKGPAFTPKEAEEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBB2</accession>
    <name>A0A0N5CBB2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MchC protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBB2"/>
    <dbReference type="WBParaSite" id="SPAL_0001517500.1">
        <property type="protein sequence ID" value="SPAL_0001517500.1"/>
        <property type="gene ID" value="SPAL_0001517500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001517500.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="71324" checksum="77304B6F5AEF6B7F" modified="2015-12-09" version="1">MLGSCKKAVDMIEYLINSRNGENLRYLQENFDLLYDLDIRRREKKKSFTLNVDLIRNSFQQVKKYYLKNFTMSQGLNNDESNFEEMLNKIFFEEGMEAPIKKYTYVTTISNGIFYREYPNYPAMTINLKEDMEGFITKEGFLTPSDNEINVILYGDDIDTTKIGHNNKNGVVTHIGYKIYHKNIVTSQLKYYRTYSVSESKKVKKNYASYLKACVNDFKNTVIQYQNRQLSIKIIAICGDNEFLQLLHGYKLNWRDIGSNNCRCCFVDGRNWKYYRSVESIEGMIRPSDLSNGLPLNNHLISDPFHDLHEGIASYALYSSVCYSKILFSDLTSSYIYQGIMHHATLLNYDKPLKSILNEKIFLVELEEIDITKKGKLPLSGSNTLYILRCFYEFLKAYISYTNIEDNNDRIKANQLIIYLQSVLGLCYLSQDPEIDVGVLKVEWVKHTNIFFKSTYAVFGERYRQFTKMHNTLHIKYMIDYYDLQLFHFSTIRFESANARIKQLLLLSKNRRNISKTIITKSMYDSYLENFKEKEEEAFIADNRNWNYDFQNMDCLDISLNRCDAEESLLENIVYSINQSLESQNTTYDNDDETYQEESFYDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCQ9</accession>
    <name>A0A0N5CCQ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5CCQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001565900.1">
        <property type="protein sequence ID" value="SPAL_0001565900.1"/>
        <property type="gene ID" value="SPAL_0001565900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001244">
        <property type="entry name" value="PRK00216.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001565900.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32032" checksum="6AD2AF20D53ABA10" modified="2015-12-09" version="1">MNIMRSVRTLCYFSKNIPKVNYSITSIRPVKTHFGFEEVDENDKEKKVHTVFANVASKYDLMNDAMSLGIHRLWKDYFIQRLNPSSNTKMLDVAGGTGDIAFRALKLIQKRSGDGNVTVFDINQNMLDVGKTRAEEDETLDKSKLKWECGNAELLPFENDTFDLYTIAFGIRNCTHIDKVLKEAYRVLKPDGKLAVLEFSQIAKPISPLYDLYSFNIIPILGEILASDYNSYKYLVESIRKFPDQETFAKMIKDEGFEDVTYENLNFGICAIHTGIKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCS7</accession>
    <name>A0A0N5CCS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCS7"/>
    <dbReference type="WBParaSite" id="SPAL_0001567700.1">
        <property type="protein sequence ID" value="SPAL_0001567700.1"/>
        <property type="gene ID" value="SPAL_0001567700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="155"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001567700.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48862" checksum="0098D4C73EDC8401" modified="2015-12-09" version="1">MQDLKNTFIGKDKFSYQWVFENLLSEDEEFQKFLSFDDNSNKKAIVKASSFDLSNGKGCFSEVFKVTFVANDGSSYNTILKIPGSSHFNEAVNKSILIDDNGNKFESNESMQKTVVQLHNRECEFYNMVKFTDCPLPKVFKAVQWEPSSNSHGCLLMRDLGVKAKMQSFSESLTPGQVMNVVEIIAKLHAFTIKNIDRIKGYNMKFPYFSKDADSIVDTQIKKLKTKFPDMFGDLFERFLPYVSNEKFSKYVTVDCHTNFNIPALLSHGDIWTNNIYFKIDNNGCISNEVEALLDWQILNLGNPTLDIARLLMVSVNADIRHQYHDAFFDHYYNILTKELGDIPQPFSLEDFKKCYKFSQLFQTRHTILMISIFTNYIPKEDKNTITQKYKEEILMLRLKQAIEDGVHIIENDLKDFEYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDF8</accession>
    <name>A0A0N5CDF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDF8"/>
    <dbReference type="STRING" id="174720.A0A0N5CDF8"/>
    <dbReference type="WBParaSite" id="SPAL_0001590300.2">
        <property type="protein sequence ID" value="SPAL_0001590300.2"/>
        <property type="gene ID" value="SPAL_0001590300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF233">
        <property type="entry name" value="TRANSCRIPTION FACTOR ELT-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001590300.2"/>
        </source>
    </evidence>
    <sequence length="723" mass="78354" checksum="1E4549FA529FA8AD" modified="2015-12-09" version="1">MILSDLSNQQFAMKDLPTGQNLQMLSTMSSDISTQQTINLNPITSDNINSENSSSCLNIIMEKCSKDKSMDTSLTHDECTTGIDIVMKTDGLCSPKNDSESSTNPDSYLSNDSTLNGSIVRNNKENEKIEECTSAITPVSMDIPPSSVDSTLSQESTDVVMSQAEEIKSNFTINCNCSCVPVVMELKQKCDMLEEVLIKLADKGETRYKKMNSTLNQLNEYIKSGKCTSHDRIPHSASTSNRSSASPALTTASISSTHSIDSSKINNGLSKNSRKRKSKVNTNNALLDSENKSKMVSESIGNTGGLDLISSLAAISNNGINTGSFSLTSKLQSIDVSKTDPIMSIVKGLNAVQASNVNIPQDISSAIQSNNPSDSVNLVSSAASIKTDDENVNSILQYESTNEDLGERLSQLMEGEKPHKQIKKETSATTTLDKESSGASLISSIAGLTGAGDSSSWLPLMMNSPHFSNNENALQSIAQLMEGGKPIKKIRKKRSPKSKARTEDSENGDNVQNGVKSEFDPLADCSNIVSEGSITENDGQTICHNCGTNSTTAWRRDLVGNLVCNACGLYYRLHKTERPPHLRKDKIQSRFRKSKKDEGNTSMVSMDTSMNTTSQNDTTLENSTLNSSILNNSHNNSSLGQGTLNNLSEFSSTYINNPALNNASTLQYPQSFNNIFSMLNQQTMNDLLSGNFNNFSLFNQPKLPQATTHDLLSAANIASTYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDH7</accession>
    <name>A0A0N5CDH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDH7"/>
    <dbReference type="STRING" id="174720.A0A0N5CDH7"/>
    <dbReference type="WBParaSite" id="SPAL_0001592100.1">
        <property type="protein sequence ID" value="SPAL_0001592100.1"/>
        <property type="gene ID" value="SPAL_0001592100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19861">
        <property type="entry name" value="DSRM_STAU_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001592100.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35597" checksum="9028573F88E1A1B8" modified="2015-12-09" version="1">MDPEYGHHINPISRLVQVVQMAKEPDPIFTFIDERSVFRRHEFICEVTWKNFRCEGCGPTKKLSKRAAAEALLEVIGYSKPMKQPGKSLLKNKSEDKFECQIDSFDITKMNSENKKEEKNGNVVEGEKKKKSVSFNPTIYGCGPPDEEDYPRIEIVPLKEDSSKKYKKVGKNRCRMLNYDDCYKLANLTKEYLTLSKEERKERPFEYLECLSKLYRFKINVTKFPERYDEDKKVWFYFVLINLNLENTVVCNGSGHSDTEAIDNAAQNILELLKDIHRKSSDYNNEDQLSVDMCNDEFVSEQLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDK0</accession>
    <name>A0A0N5CDK0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDK0"/>
    <dbReference type="STRING" id="174720.A0A0N5CDK0"/>
    <dbReference type="WBParaSite" id="SPAL_0001594400.1">
        <property type="protein sequence ID" value="SPAL_0001594400.1"/>
        <property type="gene ID" value="SPAL_0001594400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001594400.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51196" checksum="5FFD529AE7F2FAD6" modified="2015-12-09" version="1">MLLKSHQSSKDIIITTNNLEDVAEESIPFLDGIARTEYIDKLSDQNPNNELTNILSLLELGDDINDIVPGVQQIIFDEDMTNERYRLMEVDSSLLDYFTNPSTELVFRGNFKDDLILCTNERTFKVRENNTSKTYLLFPEVKSAEFFSDSNCKTIHKTISQGVSRSILTLEEQKICNTKMIEEYFKDSQLKSFLSNNDTNQLSLQNKMITIHDLLNDIQLSEKQLMSCLEKLPIVVENGKYYWISDEYQKEFFSILINAFDDSKYKDLTIETIDFDLIRQVFPESVKDGVIEWFLKSFCKLDLENSLKYTLIKDKFILSCVKNIIQVVNVMKVVEFAKLMDETLPVGLEFDKTKHLKGLGVIHSSITGETLQYLDINSLSTDVKDRMKQLFNFSKKWECDDIYPFLLDICGDIKSCDEVLIKYCRSVRNGNSRTYVGLKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE00</accession>
    <name>A0A0N5CE00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chondroitin proteoglycan 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE00"/>
    <dbReference type="STRING" id="174720.A0A0N5CE00"/>
    <dbReference type="WBParaSite" id="SPAL_0001609000.1">
        <property type="protein sequence ID" value="SPAL_0001609000.1"/>
        <property type="gene ID" value="SPAL_0001609000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895734" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="405"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="478"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="551"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="626"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="699"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="774"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="851"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="924"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001609000.1"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121390" checksum="CFD1A66134B8E7B3" modified="2015-12-09" version="1">MRLWRSVTTFLISFAILNVAVARTSQNNKHDSSDDFEHRRLRDSTTATPTLPQNFYRENQERQALKCAQLGDGNYVFGCSERFWTCRGNTGFLMHCPAGLYFNPLRNQCQYIQNVDLCQNARLRDSLVPQRAVDEFSCKDKEDGFYTKGYCDGNYIRCIDGILYNHHCPADLEFDDKKIACVERKDVQHCRTVRRMSFNAHQKKNRSPCNGDECSKDSDEEVNCSILPDGTYPPTGSLCKNFFYKCTSGQSTFMKCPKGLYYSTETQQCDFMENINECEFVFSGAVKVKKTTIKHFTVKPHPIPPAKTMSCAGKADGFYTENPCTPVYFQCSSEFSFGQVCPSGFVFDIPSKTCVAFDKCRKMKMPKPEAMPTFKPTNVPVYTTTQSTHPVPQTTTAPAQSSPVDNFCDDKADGTYPLGCSNEYYVCNYGQAYKMKCAGSTVFDVETNSCDARTHVTACGGSKPVTEMPTQGSIVIKDTFCEGKSDGVYATGCTNEYYVCNGGYAFKNTCPPGLVYSVEDQACLYKKNVLACGGSPTQKIETTPAPTVQVDPFCSGKTDGYYSEQCSDVFYHCMGGFANKQRCPIGLFFDLEYEQCDHKEEITACGGSKSPATTTTPRPIPTEQVDTFCSGKPDGYYAKGCSSEYYACTGGYTFKMYCVDGTFYDQTENRCFVKEECPACGGKLPQPTPEKPNEFLPVDTFCSGKEDGYYSDKCSTTFYICENESGEKQTCPPGLFFDADFNMCDWKDQITACGGQKTTPPPLVTVTYPPVVVDTFCQGKADGYYAQGCAQEYYACVGEVAHKMYCQDDFFYDSKENECLPKDEASTCGGIKKVYEVVSDQSTSPDHGVIDTFCADKADGFYDFQCSSDYYNCFSGFGTKQTCPSGTKFDIQNQECNFPTEIIACGGSPSPKVEQPVFAPIEVNPFCVGKENGYYALECSGKYYSCLDEIAVQMNCPAGLVYDDKFQQCLTPEEAPACGGAGPTEFTPLPTMPSDVGVVDTFCQGKTDGYYSDECSNWFYNCNNQYGNKVLCPSGLMFDKTTNACEVKKYAVSCGGQPRPKPTVYTMKEKLPDDPFCVGKGNGYYARFYIFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEL3</accession>
    <name>A0A0N5CEL3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEL3"/>
    <dbReference type="WBParaSite" id="SPAL_0001630100.1">
        <property type="protein sequence ID" value="SPAL_0001630100.1"/>
        <property type="gene ID" value="SPAL_0001630100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895753" evidence="3">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001630100.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25314" checksum="7DB8732D444E8E21" modified="2015-12-09" version="1">MKLHIQFYITIVFFVVPGYCDNFKYLHTREHHAIDSSGLHKTCNTTKFNPCKNKSQCYYTNITSEYFCKCDKCYSGQFCQNKICNLINQKDTMKLNGLAFSDFVYLAIVGITFFLSIICSSIFSWRNDQYDKKIEHGHVIDASSSVLTNDNSIMQDIASSMNLEERKKNIELEDFIINNEFINKPYTDENNNLNVRNNLWDDLKTKLKNLNKGKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CER5</accession>
    <name>A0A0N5CER5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CER5"/>
    <dbReference type="STRING" id="174720.A0A0N5CER5"/>
    <dbReference type="WBParaSite" id="SPAL_0001635200.1">
        <property type="protein sequence ID" value="SPAL_0001635200.1"/>
        <property type="gene ID" value="SPAL_0001635200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001635200.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27491" checksum="C497464D5498186D" modified="2015-12-09" version="1">MATLEDKLLNGPTITYCSSSEDEDVGICNDDPNVDNSASSYGLSKNTGPKGVKQDYYEHLQLKKEEEKIKKDLLLIEAKKFNLSSSQNKEESDSEDELERLRNKRLNQLKQRYLNSVKTLENSDEYLTAIENSRNCLTFIHIYRKNCDSCEDVDTALSSLSIQYPDHKYFRIESCILPTSDKFKQNACPALQVYYNDSLVGNFIRFDNNFNDDIIPEKVVLFLKQHDILLSNTIEADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFB3</accession>
    <name>A0A0N5CFB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFB3"/>
    <dbReference type="STRING" id="174720.A0A0N5CFB3"/>
    <dbReference type="WBParaSite" id="SPAL_0001654900.1">
        <property type="protein sequence ID" value="SPAL_0001654900.1"/>
        <property type="gene ID" value="SPAL_0001654900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="343"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="780"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001654900.1"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118738" checksum="964B6C3FAE00BC89" modified="2015-12-09" version="1">MQKSNMAPPALKPFTSYLPRHGFVEYAQQHLRMYVPEENHVQILINALPEDIREAVEDLQPEIGEEVQTICNFLDELVEEEPKKEVLEEARNQLYSISFRHTDLRSLHSYIQRTSKLVATLFEQDCNSDLVEQIATFHCIMRMPKDLAAAFFKHLEKEKEVLCKEPLHNWATGNKTSIHQRLVPGKGDKDTIVEKKRDTPKIIGPSHWTIKALISNVKLSTTMYLDSCSGFNYLSMKLWKDLGEPSLDLLDTVEIKDVGANIISCLGALVIPVVLDNIEHTWFIGCESIEKKLENCAKVRVPKLSMSFDVSEDFKPCVMPFRKLKPNVHDLVKQRLEEECKLGYLRKIPSKQVSNASPIVVVPKSNGKIRICGDYTRINKFIIIPEAQDNISIKNILQLRKEDVRYLSSIDLKDVYKQFTIYGKNRELATINTPFGFYESLRAVFGIASVPALFNNALADLIDPIPDTYRYFDDIVVISKTESGHRAALSQLFQVLEENNIVCNRQKSQIMVNSIDFLGFCISSDGTIQASNKMKGSILDSPTDSTSLRGALAKMSYARLFIPDFAKLAKSLYPKKNEKFCWTDLKEKQFQQLVQAYHQAHSLHMIEDNINTLFIDVDHDNEFVGFAVSWIKDGKPFLLYSNSRVLQGSQKRYSPALRLLLAVSIAAEELESILLYNNIVVYTPSVDIKKMFDSFASFDECISNDSTFVRLMTKLTPFQIQWEVKKKNLNSVSDVPHFLIASKDAESETILDPKLIIDEYTNDKTYEECQTAQKNLNKLISSLPKATFSSERIHIDNMVYGKSKICVIYDSFSRLTKAFFIKSYASKEMIKCVEKWIEEVGTISILVSDNHRPLISSEFDDWLKDHNIYHIRSIPYRSISNGLVERAQTITKINSSIGADKLTNCQRFEMGKANDTSVSFHDKYTVQVTALNGSGWYKVKYDDDDWEECELVSKIGQNCFKIKDGETYHIRASDAVKLSTVKVTGEFKDQQSWNIHNDEVVKEPQDPLESSDAESATTAAAPLNDDNDPINYLPDRCVNQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFB4</accession>
    <name>A0A0N5CFB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFB4"/>
    <dbReference type="WBParaSite" id="SPAL_0001655000.1">
        <property type="protein sequence ID" value="SPAL_0001655000.1"/>
        <property type="gene ID" value="SPAL_0001655000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001655000.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10031" checksum="3C561D5D5AFF2046" modified="2015-12-09" version="1">MYSTNFNKIAQIIILMCFISFAVINCEKNFKIFNEFKNAPIRAKRSGLSVGASEKLFDQVHKQSVDNAKEKVSDSYKPPQDPHSYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFF0</accession>
    <name>A0A0N5CFF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFF0"/>
    <dbReference type="STRING" id="174720.A0A0N5CFF0"/>
    <dbReference type="WBParaSite" id="SPAL_0001658600.1">
        <property type="protein sequence ID" value="SPAL_0001658600.1"/>
        <property type="gene ID" value="SPAL_0001658600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001658600.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28203" checksum="0B2F7C633AAE6F66" modified="2015-12-09" version="1">MGSRERDYRRRSDSYSRRERDYSRSRDDRRDRDHYGKSGRDRYDDSRSSDRDRYRDSRPSDRNRDRDSDRHRSTRDSDYSRSDRHDDRSKRRDDDKYSRSSRYGDSKSCDRYSERRTPERFCSSRRDERFGDERISRGSFRGGGRGFTRGRGGRGGGRGGAKLHSVVLENLSTECSAVDLMRYALDNVGMPDFTDALGEGKGIIGYHDRNKFEEMKSVLGKKHEILLQSGGKTSITVGKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFH9</accession>
    <name>A0A0N5CFH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFH9"/>
    <dbReference type="WBParaSite" id="SPAL_0001661600.1">
        <property type="protein sequence ID" value="SPAL_0001661600.1"/>
        <property type="gene ID" value="SPAL_0001661600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001661600.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="76860" checksum="1B3E6861C8A8FE8A" modified="2015-12-09" version="1">MFNISEMDIVNQLKSIVLKDEFPCFVDIILFLCLELLGIFAIFGNALLVLVLLRNKYLTKPSFVLMFSLAVADVIHGLVTTLHFYPPILLKKTIFPWIAVRIWNILDWTAWGITLTHMAAMCLDRLTAIMLYARYNQIITLQRISRFTIICWTIFLLINILFFIFNFCCMITPIKAHSYYSFSYKNDDSTEYTYKDVNIFVYLYTPLEISAFCILAISNPITLVQLYRQHKRKVALRINFQASAMLLEMSVRMGSKHISNELKDIAGRKSSRQQQRILFQISVVAVIFFSYMTAYYLYIHVITQNSKWLSVFHSFFYSTTHMINPIIHFSFNKEMRSHLRKLLIEFRFIRFLQIILNSSTSLSSFQNSTSTKYDKKTSSFNQIDKNTCDIISYNDDTKILNDTFKKERLFKTESSKSTKISFLNSEKTSMTSDGMTKIPGIIKITQIQEGFESKDENKYVLRKITANDKKSHKLENYRLNETDLSLVDTLVLKVSQKHSINEGFVEDEERNNLKRSITLSNDYNKYQKNNYDFDVVNYDEFNSQNCHFIPKSSTYTSLTTRKRNEDYFSYNLMNDKQHKKFTIDNVVNKLKIKERDDIGEHFMEEKNKNNPRDGDKNSFFSFLPQKSNINGSQSFIKNDDEITILEQIDEFEVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFR2</accession>
    <name>A0A0N5CFR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFR2"/>
    <dbReference type="WBParaSite" id="SPAL_0001669600.1">
        <property type="protein sequence ID" value="SPAL_0001669600.1"/>
        <property type="gene ID" value="SPAL_0001669600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001669600.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10667" checksum="78233E9CD3FA30B3" modified="2015-12-09" version="1">MGKRKSETNILIDDGVEDEKIKSKKWFEEDIYSNSSKNDTNSFNEWCFVLPCCMDEEESSDFGHHVSVFMVGLIAFATFFCVNLILILVFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGV6</accession>
    <name>A0A0N5CGV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NARG2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CGV6"/>
    <dbReference type="WBParaSite" id="SPAL_0001708100.1">
        <property type="protein sequence ID" value="SPAL_0001708100.1"/>
        <property type="gene ID" value="SPAL_0001708100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001708100.1"/>
        </source>
    </evidence>
    <sequence length="826" mass="95914" checksum="53806448898D03E0" modified="2015-12-09" version="1">XDDESVKISKSELKQFVEDLDTPNIITDVIVVSPNCEISEDSSSSASRQILSSTPKDYDSEHNSGKQGRRFVQPSPEEYKFYDFSNSASCIHGRGLMTKDEQDQFITQTEMLVQLLLQFIVCYHFDRIDDKYGKMYKDMLNNLLCQQACSSSNSLLRKVRNIYSAVNHYQTLTNLRVDEFNHQLMFPDTLHHTSFKPVHVYSGIVLATSDALMYPKLLPFQKFYISSVQGSVFSRSEINLMKFALARTKESQKQFKNTKSPKYVSIIEKYFPLRTTEQLRWRISSARNSKNKEINSVQFALQNKISYFEDYTKKHSEFNGIIRASFDVGQVLCPLHWLEKWMPEWLRVLKTKIMQGEYSKTFPNLTIPRNTLSEVTKPQNVPTSSVVPVGPKVIIPQGINITQPIQIIQLNEIPQVVKVPVINECSYQNSVDQVKINNNQGNEELKNNSGDRIIDPLEIEKYIAEMQNLKNQKKRNRRNNAYGARNVTDDDFANEPFREYQTSLVPSSQVSTDPTLKNYSRHDLHKIRFHLGMKKQEAIQSGTWDISKDVYDPDEVSEACVKVDEDKKRKETENAERRKRRYNLSKKISNDDNGEGRERKELKLSSNQSQKEDDPYKDLSKLQKKIKRQNDGKIAMYDPFYHNEAMKKISVIIGEDIQQKFSLHKGMLIELEELLNQYGNDQKKFIEKLEQSWGSHFEFMTQLVSILLDESNLTEEMCTNPTRVAQTNALEIIRMIYIYCHHSRGKISARNVFRTIEKEFQGEGNEIMIGKRLLEIFKKETPIYNYLKRFVQLDIDIEDLSDEEEFIDAAGGDIDFSGDENNLLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI44</accession>
    <name>A0A0N5CI44_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone deacetylase 11</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with HDAC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI44"/>
    <dbReference type="STRING" id="174720.A0A0N5CI44"/>
    <dbReference type="WBParaSite" id="SPAL_0001750600.1">
        <property type="protein sequence ID" value="SPAL_0001750600.1"/>
        <property type="gene ID" value="SPAL_0001750600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000009">
        <property type="entry name" value="Histone deacetylase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001750600.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38580" checksum="C0AF9B30704339DF" modified="2015-12-09" version="1">MSGNEEDKVSNKAIIRDSSLVPQVSLTDWPIVYHPRYNISFFGIEKLHVFDTKKWGKVINRLIEKGMITMDTIVQPNEAKQSDLLLVHTEDYLKSINESSHVIGKCVDMPPLSLFPHCILESAILRPMRYQVGGTVAAAFLALDRNWGINIGGGYHHASSNSGGGFCIYADITLALTFLFDSNRIKSALIVDCDAHQGNGHERDFKTDNRVYILDVFNHEIYPHDFEAKDRMDRDVRLKCGTEDEEYLRKLSKELTATLGEFNADIIFYNAGTDILIGDPLGLMNITPQGVIERDEMVFRMAFNSRTPIVMVTSGGYSKKSSTIIADSILNLYNKGFLKRCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIK0</accession>
    <name>A0A0N5CIK0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MRG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIK0"/>
    <dbReference type="STRING" id="174720.A0A0N5CIK0"/>
    <dbReference type="WBParaSite" id="SPAL_0001765500.1">
        <property type="protein sequence ID" value="SPAL_0001765500.1"/>
        <property type="gene ID" value="SPAL_0001765500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001765500.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32372" checksum="C0160C695476AE89" modified="2015-12-09" version="1">MDQIEKYCLNSVSCMLMFNRLVSLIKDFIQVVNNSTFQVDAVNINTENILDNKSDVLELKINKNFVQLDKTRKTIGKKNLTKRIKRLSNNIMKRGHTSLTVDPIQVDNDSINKKPKLTRKNKNFFRLEMRKLFPYGKFLNPLPVNCEHYWLKHKNKAVPIYKLVLKLQENKNDIILYLSQVTEIAAIFQSEDSQVLSYNILSSLENSLTYPLFFSTEAFGWEEKKAYKKDNKQISLTKLVYYQNLIAMRLLLNPLHHGALLFQLFVVNAYTTIKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Q8</accession>
    <name>A0A0N5B1Q8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Q8"/>
    <dbReference type="WBParaSite" id="SPAL_0000001300.1">
        <property type="protein sequence ID" value="SPAL_0000001300.1"/>
        <property type="gene ID" value="SPAL_0000001300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000001300.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25146" checksum="BDF6CFC64EE7EC67" modified="2015-12-09" version="1">GSINTQLEKFMESVKRKEKDETENNERPSGENPFIEGLSILESGNDQIKTSVDKPTIINEELKDMVYQMRERCFEVDGKDRIENMRLRKFLDDNTIKRKALELIQNEGTFCKFVADILISNSQILKFYFPSQYTRKNKDQLFGQDIVKAFMITAKYLGAAIISEFKHYLSHGIHLVNTRTGDKVKRKANVTFFELSHKPTFFSEEEIVSQENDVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1T1</accession>
    <name>A0A0N5B1T1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1T1"/>
    <dbReference type="WBParaSite" id="SPAL_0000003300.1">
        <property type="protein sequence ID" value="SPAL_0000003300.1"/>
        <property type="gene ID" value="SPAL_0000003300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000003300.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21071" checksum="A99B6C2BA3D48D1A" modified="2015-12-09" version="1">MHGKIYTTLFCICCLINLIICGLLIYIMSKSMDNSEKPEWAIILSFSIFIFFTIALMVTFVVWRRFKKDILLILCVTFTVGQCLCMVVSGVAFYVDETYPTKDALFTSNPYSWLEFHRFVFLSAVILLLPIYVCQLFVINRHSGREYMAMPTSEITGSDYIVRKNTPYINSQKKYQRKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2F2</accession>
    <name>A0A0N5B2F2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2F2"/>
    <dbReference type="WBParaSite" id="SPAL_0000025900.1">
        <property type="protein sequence ID" value="SPAL_0000025900.1"/>
        <property type="gene ID" value="SPAL_0000025900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000025900.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14757" checksum="2C52A38EE31A3668" modified="2015-12-09" version="1">MINIFLLFNDKFPRFTSFFQEPLKMNSRFKLLFLIITCFLITQGSGFFFFQRPEIIEVKNGNGRPNLIRLKKNTEMEDFCNEDYALECLTFPEVLDIKYCLTSICSKCYKMNNYKKIVNICKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2H2</accession>
    <name>A0A0N5B2H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2H2"/>
    <dbReference type="STRING" id="174720.A0A0N5B2H2"/>
    <dbReference type="WBParaSite" id="SPAL_0000027900.1">
        <property type="protein sequence ID" value="SPAL_0000027900.1"/>
        <property type="gene ID" value="SPAL_0000027900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893780" evidence="2">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000027900.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25844" checksum="8186D3B1777F1549" modified="2015-12-09" version="1">MIILSRISLLLIALILEARISYADDYEDWPPGELKAAWYTVPIINLTEYKNRIKERHRQIDERVEQLIKDEPRKYKEIMAKIKANNGTGDGKKGDVAKPGTNPQVNITNPASTPQNPVLGVESNTPSVPKFQVHATTGASPSNPNTNQATPSNNSTEAPLPSTGTKTGDTSYNGSTNAPPSSTLNTNTAPPSTRNTNAPPSSTFNTNAPPSSTQSTNKVPSSTTTENNASATEQTGAETYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2P1</accession>
    <name>A0A0N5B2P1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2P1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2P1"/>
    <dbReference type="WBParaSite" id="SPAL_0000034525.1">
        <property type="protein sequence ID" value="SPAL_0000034525.1"/>
        <property type="gene ID" value="SPAL_0000034525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000034525.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28845" checksum="42484EEA5EC79A3E" modified="2015-12-09" version="1">MQHFNFSLSYRNTSVFGEADTLSSGDDEIIIAESSLPWILLLSDNIISEETGKDAILSNVLLWIFKEWKNFSLTKDNAGLRWYSQNRKYLRSFNGLVLYKNRICIPDSLQSKVISILHNDHSSFSAMITRFRKDINCPVCQANRKKPSRTHSSWVSTYPREFVHCDIMYNGRQTMLVFVDSFSNFVSIYPLSSIHKTKIVELFRKFMLTYGQVKHFVCDSGTQFQNLPEEFNCIVCPPEDHQGNGKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3E4</accession>
    <name>A0A0N5B3E4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3E4"/>
    <dbReference type="STRING" id="174720.A0A0N5B3E4"/>
    <dbReference type="WBParaSite" id="SPAL_0000059500.1">
        <property type="protein sequence ID" value="SPAL_0000059500.1"/>
        <property type="gene ID" value="SPAL_0000059500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF6">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="110"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000059500.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43293" checksum="2171A5AC9D7FD838" modified="2015-12-09" version="1">MNPPKKESDEFIKYAEHKDLFTIARAHWIQLFKVNMQHTVIAQTFINIAEQHPHLKPYWTFMRTSRPFDTIDVDSLDDDLESLDEDVRQVVNSGTLQDSSTFITANLKDNHDHKFSNHISTVQAAMTILMDNIDDYKSFVKVIREFGSYHFFYEAFEPHFELFHQHFMAVIKKLLANTTEEVDDKIEESWNALFEELKENMSYGVALQRHIYLKTAFTIDDILVVEDDWHKIEEYGLDKLGNLIYNRMIVKYVIILKDMDISLPIDINVEYKKIKQISHQIIYALQTAIKNYSIEDGFANLPELVTDFTLNYTLVTICPMVFRKAFNDAFIHSLSKLIGNDTMKECKIHTWGKLYRILEQAIMTNIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3T1</accession>
    <name>A0A0N5B3T1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Post-GPI attachment to proteins factor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3T1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3T1"/>
    <dbReference type="WBParaSite" id="SPAL_0000073300.1">
        <property type="protein sequence ID" value="SPAL_0000073300.1"/>
        <property type="gene ID" value="SPAL_0000073300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF15">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000073300.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33252" checksum="4DBABD1B334A40D5" modified="2015-12-09" version="1">MSKENLPIPNSLSLTSRTFSPKSPPPSSFSPSDWMLYFNSKFVILAATLFPGVGCYACIAYTYLFQFDKVVNFASDHCNGTMSYIPPVSYSIGVWKPQKFFWLSVLMLHVPPRIIYVELCNKFFLRGPNSSNPDNYYFHILLSMHRFLMHLEIWALVGVSIFDIEFNFLIHAIFFGFWLASFNFNMLFSVILQYQSGINETDSKYYTLFKIKRLMFIVGCPISLTASASYVYYLKSCKDLAYVTFSITEYTTVGMNSLFHLLSYIDADKMSLDIAVVPSVPGKTKSKMCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3X6</accession>
    <name>A0A0N5B3X6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000077800.1">
        <property type="protein sequence ID" value="SPAL_0000077800.1"/>
        <property type="gene ID" value="SPAL_0000077800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000077800.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11214" checksum="71FF455E6A5B306F" modified="2015-12-09" version="1">XNITTRGVLTAFPNLAVIVYRDCKFTRSVQLPGSIRIIICCTRICQCNLGKIRGWQRPYSVKCGPNVIGGPASLYFKTKEDFLCFGDYSGVSRIRHTQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B460</accession>
    <name>A0A0N5B460_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage_integrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B460"/>
    <dbReference type="STRING" id="174720.A0A0N5B460"/>
    <dbReference type="WBParaSite" id="SPAL_0000086200.1">
        <property type="protein sequence ID" value="SPAL_0000086200.1"/>
        <property type="gene ID" value="SPAL_0000086200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000086200.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19360" checksum="62971C77FB2CADC0" modified="2015-12-09" version="1">MREDNDHSLKNISMKLTTLLAISTGKRVSEICNIFLSNTKLDTDIVVRLPKTKNSEKNIPNHFLTIISYPEKALCPAATFYEYLDLTKDIRGKSDQLFIAYEGKKKGEPISKDRLSKWIRLYLEKANIFTNPHSIRSNMSSQCALSNIPIKTIIEVTLAKMILDHHKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B479</accession>
    <name>A0A0N5B479_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B479"/>
    <dbReference type="WBParaSite" id="SPAL_0000088200.1">
        <property type="protein sequence ID" value="SPAL_0000088200.1"/>
        <property type="gene ID" value="SPAL_0000088200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000088200.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11716" checksum="F7FCF1253AE69935" modified="2015-12-09" version="1">MILIKFNIFILFLYIIISIWSIKIEEMNGNINDNFLQQHIRVKRRIRGIRIFLRLGRLALRGVRRRVRLLRRGGYIYENNNMYGYNNYYGNNYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4U5</accession>
    <name>A0A0N5B4U5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4U5"/>
    <dbReference type="STRING" id="174720.A0A0N5B4U5"/>
    <dbReference type="WBParaSite" id="SPAL_0000109400.1">
        <property type="protein sequence ID" value="SPAL_0000109400.1"/>
        <property type="gene ID" value="SPAL_0000109400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="EH" evidence="6">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="722"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="907"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000109400.1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117298" checksum="29F300E589926BC6" modified="2015-12-09" version="1">MASGFFNEVHDREHAIFFLTTAKGGNVISYQDAIQFPLKFGLNIMIIEQAAILSDFFNGGSVFDWKRFCTFAYLCRAIKQGYILTTPLDLKWRQVPIPNLEGIKQQLFSMGMTFGNIIKPNIGVYQPSTPTPFDERKSGENWNLSANLKAKYAQRFNQLDTQRKDYLDPNVVTRVLRESNLPNHVLAKVWEFCCGCGPISRGRFIAAVFMAEKLAEGYTLPSVLPDELASVITGMPITYSPSTVQTFHQNQHGMTFEEKRMDNLKRSEAVLQPRREALLEQEQAQKALLMRKQEEERLRREQEQQELARQKLIESLKYEVKELDGKKKDLTRLVERLSEENLNVQHEIEKAEFTLQGIEENTKELSSEFQKDVETFRNMTQAHTDAKSNFEKCVHDIDKYTKEIHLLAQEIAQNSHEMLQLKSRFASTPELVQLEETKNELSQDIEYLKNEIEALKEVASNDEIFEAKAQHLEKENAQKFSTLNSTLMIAAENYMEKYNELNTKGTAKGMVNLDKLYQMAKEGKPIVAFPNAVQGSDMSNIDTTFAPSSVYPNPFSDNKNEENIDPFANVEKIDDNYNYGDPFSTSNKNGENEDFFGGDPFQSALVNNDNQFSEPWPEEVKESNLFGDNNTNDKRNNQNINGGDDSATKVTTINSTIEDPFAAAEENSKPLTNGSVKKNDFPSSNVFDSFQDTTSTSNYQVEDPFSNKNISSTSDKFVGNDSNIRCYKALHNFEAPKEDGEAISFSINSLCMTNQPENGEWVYGVIDDKVGYVPTNYFKLVGDFSTDTETVKKVEKLIEDGLNRHGTQDPSHSDDTGGNYIHIFSEDNKKFPTQDSVGESIYPEARMITPWKYEFNGESCFIKQGEMLPVIEQLDVQTKVLHNGREILIPKALLSSVEGIPVKTDSSGKMKNSKSSSSVQYSYGKSGVGETRSLQELQEKIRTDLTFSDTKASRTEEHLAKLHSPRSSQNKIECASKIAVAEYDFEPRSDDELRFKKGDKIIVIDTTDGSWGRGYLVNSADTTPMYFPMNFVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5C5</accession>
    <name>A0A0N5B5C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KTSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5C5"/>
    <dbReference type="WBParaSite" id="SPAL_0000126900.1">
        <property type="protein sequence ID" value="SPAL_0000126900.1"/>
        <property type="gene ID" value="SPAL_0000126900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7381" evidence="3">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000126900.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="22318" checksum="39276336172398B0" modified="2015-12-09" version="1">MNCNLKIFFWILVELNFVNCQIVTVQYFHKLMRGKTFFSYKKGNYLTKEDMIDVILRDYSNLPICCLYLQEVEVEKYFKKYIKRKFLTPEPLLNSITKPQKWPCSTKKSCPSKYKIFVLYIGGITYYEVNGLAFRSLYYAQNYVLGKRNRRVRFGNEHSVSFNKKEPPTYVRETKRKSRERSRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6R0</accession>
    <name>A0A0N5B6R0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6R0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6R0"/>
    <dbReference type="WBParaSite" id="SPAL_0000174700.1">
        <property type="protein sequence ID" value="SPAL_0000174700.1"/>
        <property type="gene ID" value="SPAL_0000174700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052630">
        <property type="entry name" value="TTC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091">
        <property type="entry name" value="TTC17 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893845" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000174700.1"/>
        </source>
    </evidence>
    <sequence length="1074" mass="123953" checksum="106DCCB3984A6EE1" modified="2015-12-09" version="1">MKLICITAGIILSLFILFLSVSAVTHWQINQDGTVIQPVSNSPYQMKTPQSLNKMMEQIKNVDMLITNRENVKREIAEIQKKLDKDIPDLEDQIRSTDGDCISSRDLESTESSDVGFALLAAGKIEEANNVFREEVNKNPGCELARKKLAYARCYLKLKAALESSHRNLMSIFEKYDRYKERLSFVQELQKRVSDNMLDEEERKQSMLVADFFSYGTIDYSICKPVVENNKMAIKCKVSDWQNYNATVFMKYINTFTTEFELRKNKKKADSTKQNKGPIYVEQPLSIEEIKLSDKFYRSLRKFANIDTKDLFEEIGFQKNGFVGKYKFYNENDDFEMKSRLKSIQGKEFDNSIFSILHTKGRILGTPKEISDVAKEAVTKYLNLDGKLNHPLPWLEPYCKKPDPRIIQSPDKYMRDELYKVTGLNPNEVPLVEVGQRIKTLMDNNFKPFWLLANLAAMYFRAIGRIGDAYNCLKYTVEHEYEAYDNGYTLFHFYDINLFMPLFNYTAQNSMTNSQELLKQMNEGEFKKHLDNNPYYLYLYNLVHLTAYRENANFNKIKKSLLKIVHLKDPQDSILTSNAIECLEILKCLEEFRKSLPTNKYYLGCCDKNDNVYCLPSTNYCFAPSKYPIGLCCSSTDTSKKLDGLSRLLYYILPGKMTNEGKKRVPLMVSDPISLAIINAANKKIEKEIKAEEEKFDINSQAAYEMPLDYGGYDKNLFFKNTRFVKKQMHKFKDSIVVFDAPEKEVNVPLEELTSLWKNIDGEMVRDLKNIKDRREILHYDLKFLNKIPEPFSEQVKKGMIYLKPPVDEETLTTFCYMYNKNPINIDQPVSTWVSVTAKGINMEDYLDLNMVVPGIANLEPVCPGIENDKDDISKLTLDYLPAFLYRDQFYFYKPEKALKDTLRSLGNEGEKIEHVAARLTLAMRVSKMSSKTAENQDSGVHWTLTTASTLYWRVKGDAVNAVKCLRHSLKNAPSNMRDVALINMANIYHQAGFYHSALYAGGRALEISPELVAIHFTLANIYASMGDNDRALKFYYSTIALQSNFQPAKDRIRAIVCQNKDNSFELIERLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B730</accession>
    <name>A0A0N5B730_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B730"/>
    <dbReference type="WBParaSite" id="SPAL_0000185800.1">
        <property type="protein sequence ID" value="SPAL_0000185800.1"/>
        <property type="gene ID" value="SPAL_0000185800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185800.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15041" checksum="317A2932469FD7FC" modified="2015-12-09" version="1">MNYLNVSIFIIATFLIVVETFPSFHKQRELFKMKQKDPKNKKIIKLAKQSVAHYNRKYNMNSRFAGVLKAKKEHTTDSSHYVLVISTMTDCGGNELVCLEEIHSDVYKNKKNPTHLSFYVHKEGSPDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7L9</accession>
    <name>A0A0N5B7L9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7L9"/>
    <dbReference type="WBParaSite" id="SPAL_0000204400.1">
        <property type="protein sequence ID" value="SPAL_0000204400.1"/>
        <property type="gene ID" value="SPAL_0000204400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000204400.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20810" checksum="6127C61505D47CCE" modified="2015-12-09" version="1">MNEKISNDYCNRSEQSSLSITTTSNPTTNTTTSNTQDIRIIQEKTSNCKPTTAILTLIQFIISTIQLLDITLNLILKIHLFIHYEALISMFALWTLSMVWVIFTLIMFGGIIFNNGILILSFILFNIFFTLLSFGLFILLIFEKSNIYSIFYVFFIFIVLQLTTNYSWSFFNELCEANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7V0</accession>
    <name>A0A0N5B7V0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7V0"/>
    <dbReference type="WBParaSite" id="SPAL_0000212500.1">
        <property type="protein sequence ID" value="SPAL_0000212500.1"/>
        <property type="gene ID" value="SPAL_0000212500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000212500.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15761" checksum="52FC5A73ED80B80A" modified="2015-12-09" version="1">MPEHYLKHLSAPVTFGRMVADLLLNKEQQQFFKMVFRSQRASNRRPMPAKYIRRMRAILEYAGASVIQEEERDEYMACLYAGLNDRSLNMKKSGRSRNVRMYIIDGLKIYWEDEMELLELMKEKDGTTEAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Z1</accession>
    <name>A0A0N5B7Z1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Z1"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0000216500.1">
        <property type="protein sequence ID" value="SPAL_0000216500.1"/>
        <property type="gene ID" value="SPAL_0000216500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03670">
        <property type="entry name" value="NUDIX_ADPRase_Nudt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF8">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000216500.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30560" checksum="BDE4537A8D9EDF8D" modified="2015-12-09" version="1">MISTINKNCLVTSKPYLFSNVFRIKIPENLSKWSDKWDEYNPPDYTSVEATYKSWSDDKELNDTNYKWNEIDGKINRKSFMGHYQISTDNRPLNPIGRTGLRGRGILGRWGPNHAADPIVTRILDGKLQFVAIKRKDTGEWAIPGGMVDEGENVPTTLKREFTEEALDNIPSNYVEELFNNGIHLYSGYVDDHRNTDNSWMETSVYLFHDTKNLLSSVNFKAGSDARAVNWITYSESLSLYADHKKYLSLAYDKLKKVLQSTLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B864</accession>
    <name>A0A0N5B864_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylosome subunit pICln</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B864"/>
    <dbReference type="STRING" id="174720.A0A0N5B864"/>
    <dbReference type="WBParaSite" id="SPAL_0000223700.1">
        <property type="protein sequence ID" value="SPAL_0000223700.1"/>
        <property type="gene ID" value="SPAL_0000223700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000223700.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21679" checksum="F7AF382C9BA9BBE4" modified="2015-12-09" version="1">MITLQEVLAPHEGVRFTEENVQLFYEVERISNGTLYIGERNITWIEDGRGRGIVIPYQALVTHGISNDISAFPDRCLFLTIDVSKINFIAQSSMENMNDDDDECECIYLRMVPANDSLNIIFQIMTECQEMNPDEEDMEEEYNSGFQTLNGESNGWCDGTNSESFSEMSELGMDNYNRLFGDKKNDSMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B928</accession>
    <name>A0A0N5B928_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B928"/>
    <dbReference type="WBParaSite" id="SPAL_0000255000.1">
        <property type="protein sequence ID" value="SPAL_0000255000.1"/>
        <property type="gene ID" value="SPAL_0000255000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000255000.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28052" checksum="0EA49CCE6036BE20" modified="2015-12-09" version="1">MKYQFNKCLGNKQGQIKEKYMKDLLKKYNCKLESIGDTTVKVDGSSISYSYKTVKKLDSINPKDLDQVDYSQEIRFSDIKDLNEKICKDSCKISKIKCKNYGIVNPNGCKNCICPLFYEGKYCEITKKGKIPAICGTEYLKASSKTRTKTLNLDNRSKCFYKIKPTSTKKKVVVTFKPNDEYLHTSCDGQGFEISYYNDKSRTGVMPCGEFKTFNVTGSRGATILIYSENLFAPPSSKMTMEYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B968</accession>
    <name>A0A0N5B968_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Forkhead box protein fkh-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Forkhead transcription factor family member fkh-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Transcription factor. Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B968"/>
    <dbReference type="STRING" id="174720.A0A0N5B968"/>
    <dbReference type="WBParaSite" id="SPAL_0000258500.1">
        <property type="protein sequence ID" value="SPAL_0000258500.1"/>
        <property type="gene ID" value="SPAL_0000258500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
        <property type="entry name" value="FH_FOXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00077297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000258500.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33381" checksum="22BB68AF67DD37F8" modified="2015-12-09" version="1">MASKFSIMDLCPDLANTNHSTPSSPESDSSVDKQHSVTLDDLSDTRSSSNITKDSGITSKGIDDSRNFDLSPSTSPDGVDVLEGGEIPENSDSLSSNKKPPFSYNALIMMAIRNSKEKKLTLSGIYDYIITNYPFYRDNKQGWQNSIRHNLSLNKCFVKVPRNYDDPGKGNYWMLNAACEDEIFIGGSTGKLRRRPSGFNRGRFDAFKSVQIPSYPYNLSGSQNSLIFNNPQNPLINFSTPLLYYNQPQVNGTIGGGRILPQVSGPIPGQIPGTLNQNNINQLLSMYASAAFQLPFKEKQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9I5</accession>
    <name>A0A0N5B9I5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9I5"/>
    <dbReference type="STRING" id="174720.A0A0N5B9I5"/>
    <dbReference type="WBParaSite" id="SPAL_0000270100.1">
        <property type="protein sequence ID" value="SPAL_0000270100.1"/>
        <property type="gene ID" value="SPAL_0000270100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="282"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000270100.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="63674" checksum="3E8E4F5481157B9B" modified="2015-12-09" version="1">MKIEKSYIWPRGDFSVNVDHSYISFGPSHVDTFKLALQFISYHGYYNRTPYITFGDWHHIAIQKMLLTDDIAVEFFISAKHLEEMDSDNEKSIINKDDLMEEVVINSDLSIPLKNHDDKNIKIGRTKILFLALVIVMSGYKNFFSNECQNIQSFRIIHEYIKRNLKQFCSILLLCNPILMKRLIKESHKPVECIDGSTKIHIEHLHNFDIVFEGTIVDLLENVDERSILPQKCWNILSRKIVTTFGGNEIRFDEIVYVVDMILQQDMFAIHDLPADNINDHPKQFNHFEQCHKKFTPSLGKKYRKLVIVNWNHIEVFSSPLYSGINLKLTNGNNRSSYIFYPQYACSVIISDTYDCLPIIIGPVKDIIFINNVHNTSISVITYRIIIKNCSNLTIFLSSYTSPIISSDSKGIKLAPYNVFYSNLEKQLNASKMSLLPYDKNQWSKPIILDELFPQSMCNSKNNGTDKKVEVYNILSPDSFYIQPTLFDTDFNSDFFKYFRTKTIPPKFIKSWETSLKKVYQNNKDNFSNTMDALSKRDIQYLLKKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9N6</accession>
    <name>A0A0N5B9N6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FSA_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B9N6"/>
    <dbReference type="WBParaSite" id="SPAL_0000275200.1">
        <property type="protein sequence ID" value="SPAL_0000275200.1"/>
        <property type="gene ID" value="SPAL_0000275200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="2">
        <location>
            <begin position="1596"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000275200.1"/>
        </source>
    </evidence>
    <sequence length="2166" mass="246917" checksum="D6FC0BC1D2E6140B" modified="2015-12-09" version="1">MTLKHFNYSTDLYKCNYYNEIKNNNDQFLIKENRKNAIIALLSHWQTVICSHVTLVDNHVAHKFKKVPEEDVLTEIKKLDKNDLKNGHHDSELSSGRVIIDMDTPITSPSKNTVNKNNELLSEKNIPVFEHSISRIQRGSIENNQSTKRPSHSRNGSALNTKEVNKEEMDLYHYVKTAANELKHKNKKRLSETISIDSIVNGMELLLDVFFWSVYHQLQLEKSVFDGFPNKKVRTNIKINLYEFKIEVAERKARKNKNDEVFSSISTHTILQINNFRAPGNFTINAIKDMKQFKLNKLDFSMEYEAEIESIKLGADIATVGFTNEILLLVLSLMENTDIPADARKSFASVMATSNSSENNWAVSVLDKLNDYQRGLSRKNVKGKRTAIRMDIRGMATLKTVVLESVFNDLLLSIPFHDISLTHIHTRNDLAKAENKEVIRSDAVTLRIKKGNLRLTERADTSFNKEARDILTCTLKESTFNFKRSINSIDTYTERSFIKIKLGDVNGYIPMHAQFVHEMVLKHGPQLNEQFNRLSIHQIKPSYATNFSPIPINTMPDGSNNTAIEESYLGPKNSFGIEDVNKVTIKREKNQQLSKKRAWTFIVDFDVKLSTILLNARLLPSLNTQYKLSRASANGTIGKDINFEFKIFEHGMLFEVVNTNINDTNDYSDTFALPLPHIYVEGNQQSSTANEILSNKTNITSNLTLKEGNYYDITIEVGKIEHSFSTDLLNQILFAEQSFRSELTHVLKRISRMKMQPSDEGLSNPNNSSNTSNPPFFNINIKGEGIPWCQLTASTPTSTAIRFTLDNPTLTLTNRYKIASDTSNKITNPWIGRAKIQVNVKLGQFYKNAMFEEVDSELQELATFMTQISAQNEEISLVSPNNYVFSLNRPILYIKSTAIDKAILLWLNYKNTYDFWRKERDKFYSSTVDEKDEYDMLRNDVNETESSDMNLNLSLSIQNGLYVCMPLFSTDCNDNLSALLISLQRSEITVSIKKELACAADFNSFKISFIENFDEHSLSDSWLEKNTGDSNHSNFCYFPHGSYKLFSSASKPKENERAKWVLSIKSHMKGMTIDFSDKIGKFLSLLTQTFSNFGNFDDFDVNQESISVIGDDEINADLSDSDEEFHSLGEREDRTRWLERKMHQKSILVTDLMQCHLDEIKIEHERRKLHKLELAKFKQFRKSVVEKIKKRAGASKSLKSDSSYSSQNDFRNSVKNDKYKQSLLHNNLPKIEEGKNDKNYIVEDNEKIDMSIDVQLNIETGQCILRCNPVKLPSFNTAQNASKLPMKPSSKNLNHIVSNAQEDKYSMKLSIPSVGVKVFYTSNDPLTSKPSDIAKIFKDEIKERKSHKNGCFYLALELAHMPQETIVTPLLADYLEQVIEPLPQHFFESSSPGPHSDVLSDGMPIVAIDTSGLPLDVLFHLNVQSSTIRFEGQQFRNNAADCLLTLPRLTLMVSTRKYNELDRTVAGIHISAMLSNFSLSIYSPHQQSTSHDALSLGLDSLSVCVSRTKNPPTPEEPNRIQLVITTTIGVANFNYDLRRLSELLAFPKPWYRKILVKRIFLGEYAVNINERRFSSSTINISSERFPLTKENKNEEELGGNNKHIESKVKFVASAVYSLQWKELKVKAQMSNTMGNTEWNALKGTIRGNFDINSDGQRKFNIMFKLDSSMLQANGGAISGNIGINKLLIALKHGKEEKKPPKNCLKLQLGFFESQIEWMSRTIFVGRFTEPQIDINDEWKTEYDVYDDETSQSFCFVNIAGSWKDLQMIITKNTIGDFIKITSKLHNFFNEQLSSSRFVWGSEYDLGKLHGDPSIDSISLSDSDNGSISEDFSESSFNFSSKRYWHKIMDILTLLQVQKPDLLSFPTKSNDGTIIGGTIELDAQKASVACMHGDMNATEWALFHLSEVGAFFKTWTKCCFMNNEETETGVNIEQKLDLKLGNHGIHGMSISECKGLVCRVHQARNFSLDNNSTISFCLKSIIGDALRNTSLHFPDKIEPKFKHKVVEMFILPAFEAVLNTVQKQHSKKSHDTNQVVDCSFICDFHDLVSLLPDPNSQLGFLPKLIQSYKIDDPDQQHGDKIIIHSKEGSRDTRIYECHTWHVDPRLQFLNTNRSKWNSPVIDDILKMLKIYDYRKTIPKFLQRGVLDNADAIIALLIKEILNLAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAC1</accession>
    <name>A0A0N5BAC1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAC1"/>
    <dbReference type="WBParaSite" id="SPAL_0000299100.1">
        <property type="protein sequence ID" value="SPAL_0000299100.1"/>
        <property type="gene ID" value="SPAL_0000299100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000299100.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17324" checksum="736B5A708B9394AD" modified="2015-12-09" version="1">MMPEMQMEKQNDMQMHMKNKMWMWFHTSLDDTVLFSDIIIKDVKGMIICCFIFFVLSIAHEFLKYYRWSFENNNRSHENLSYFKRIFSINSGIRTILFTIQVTLSYIIMLIVMTFSIWLGLAVIIGTGIGYLIFGSRIHKRNRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBP8</accession>
    <name>A0A0N5BBP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBP8"/>
    <dbReference type="STRING" id="174720.A0A0N5BBP8"/>
    <dbReference type="WBParaSite" id="SPAL_0000345400.1">
        <property type="protein sequence ID" value="SPAL_0000345400.1"/>
        <property type="gene ID" value="SPAL_0000345400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="112"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000345400.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32454" checksum="269C1453A517D722" modified="2015-12-09" version="1">MEAYVPFVYRRKKDYGSAKEFAKEVSKWMHAQKKANEYQNTAHQMAHQNAHNAMMMSFNLNQQGMEQGMGNFFGVGQNTVHFNIQAPRDPNWLRRYLWRLDSDVRVTENVIVASYSKRLLAELLDFFIFFFIKLGLLFLIVEVGYLDIQEYERFLTDEIDIQNLLDLSQGLLPADLLCKFISSIVEATMISFGLSIFPRGCTPGKFVMGIKIIDCVSIQPNQEIPGSYTIVRTEGVSFAKALARSFIKNFAISFFYPISCAAYVFPYNRAVYDVVAKTLVVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC95</accession>
    <name>A0A0N5BC95_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC95"/>
    <dbReference type="WBParaSite" id="SPAL_0000364300.1">
        <property type="protein sequence ID" value="SPAL_0000364300.1"/>
        <property type="gene ID" value="SPAL_0000364300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000364300.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="30051" checksum="98D712D8F0B163AF" modified="2015-12-09" version="1">VIIKEIKNKNVNFNKQFYIIIVCKLTNEIIYIITIFTFVKLPKWGFYSNFLENNNWTATTFSYILATQQTTFMFFITLLISINRYIAIKYLLLYKIYFSKSKIVIILLSFIILSTMIGLGNTPFNAKYEKLELYGYFIPIFKSKNVIYYHIFYQIFLFGIIYIATCIFNIMAILTLKKHKQIGNKYKKELYYIIYSIFTFITLFIVEVFFVCNIIRVKYEIKSFANVIYFLHTVAFDLTTVGDFYFLIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDI7</accession>
    <name>A0A0N5BDI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDI7"/>
    <dbReference type="STRING" id="174720.A0A0N5BDI7"/>
    <dbReference type="WBParaSite" id="SPAL_0000407200.1">
        <property type="protein sequence ID" value="SPAL_0000407200.1"/>
        <property type="gene ID" value="SPAL_0000407200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="200"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000407200.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46130" checksum="127ACAE716980B41" modified="2015-12-09" version="1">MSDDVVRKEKQQFKDFTLLDWILLLLLICSNFTCPLAFSCISPFYNTVAFTKGLSLSECGIVFAIFNFLGIFASPVIGPLIPKIGLRILLPSGMIITAIGTLLFAITINIQSESWFFIVSLVLRLVQSMIETFVGLGYTLGPFIGGLLYDAGGYILPFIVLGVILLICGILSIFFIKVDKDESFIRLNYTIYYKLVKIPDVWIIMGSAIFAGIAFQYHDVTLPEVLKEFNLSSSQIGSFFLLMGVPYAILTPIYGFILDKYGGGSYFIITGSIFSIVAFYCFGPAPFIPFKRNLVTLIIMSIFEGISVGGLYIPCFTKSLKTLVKDYHFPENLETSSLLSGIFGMCYSFGAVLGPSGGSFLVDQLNYEWSTFIYGTAMLIYLFIFIFLYYIPRNLRKNKVKNIEENLSTIVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDM0</accession>
    <name>A0A0N5BDM0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDM0"/>
    <dbReference type="WBParaSite" id="SPAL_0000410300.1">
        <property type="protein sequence ID" value="SPAL_0000410300.1"/>
        <property type="gene ID" value="SPAL_0000410300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000410300.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="39560" checksum="E0BA23E69AD3EFAB" modified="2015-12-09" version="1">MAFSNTTSIIEIIWMVIQILTYIFYLLIIIYICKKKDSRNLTHTFDVSLRTHWTANFLVNFFQFVTIIFYQKIPYWSGRNYYFVDNRIIYKLYPIMFYGPITSCVIGNIIIIFNRFFGIMYPLIYKNKWNLKVCYIFIIIQIFLPLILYSYTFNSVVELIIDYEFDRSYFDIESPFSRIATNITLGIIVILSAIISLVLNLIIWIKYKKFFEVKVKDQDVVQKFSYFIYTLILSISLFIFTIQQCIRFESIFYNDQEQRNSLSLWIYWVLPFITTFQPYYLVLCSKSIRSDILHTHGISYVKENYCQRSIFTRNGTTNRTIPNKTWISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDY6</accession>
    <name>A0A0N5BDY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000421400.1">
        <property type="protein sequence ID" value="SPAL_0000421400.1"/>
        <property type="gene ID" value="SPAL_0000421400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000421400.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16461" checksum="371B7F23DF90B7E6" modified="2015-12-09" version="1">MLQFFKKCKFNTIKFYIYFIILLILLYLGGIIFFKDIWKTNYDKNENICMKEKLNAYKNLESEMIKQQERVSLGFTSKNIFKNTVINLFEKIDSCHRTNESVKESQLNSYQTAFFIFSLLSIPIFVLLAVEIYELMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF02</accession>
    <name>A0A0N5BF02_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBM49 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF02"/>
    <dbReference type="WBParaSite" id="SPAL_0000457200.1">
        <property type="protein sequence ID" value="SPAL_0000457200.1"/>
        <property type="gene ID" value="SPAL_0000457200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894483" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000457200.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16171" checksum="C346DF39F0509002" modified="2015-12-09" version="1">MFLKLFTAFTIILISRSLTTNVDISLENNKEFNVIVEGTLSWNDQNVKNVKGELQKNDKTVTSAKYEQNPSTIYLTAYKYTTDSLDAFSVKFGYDVADSGLQGELVKKIPENCINVNSDVNDETLNLKDGDFTCNLGYVYIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF46</accession>
    <name>A0A0N5BF46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF46"/>
    <dbReference type="STRING" id="174720.A0A0N5BF46"/>
    <dbReference type="WBParaSite" id="SPAL_0000461500.1">
        <property type="protein sequence ID" value="SPAL_0000461500.1"/>
        <property type="gene ID" value="SPAL_0000461500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="122"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000461500.1"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118509" checksum="0F70731208A62894" modified="2015-12-09" version="1">MLTELNVTCSSSTTSLTSVDKLSSNNDENLDTGNKVVFRKKEKNENDRGNIYMVIYECKVESKKKDMDLKRGSTIKVVKTEKRDDGLIEAEVNGKSVLIPEEYLVEAVREKNIIERNELEYDELTSRIGSGAYGTVYKAKYKGEFVAFKTSINKMSNPNKMPKELEEELSILSMLKNRNIIKLIGECRTIKSMGIVIEYCAGGTLSDIIHKKKINDELCYILYLKQISDGMSYLHNDSKCKYLLIGNEGYNVIHRDLKPQNILIKEAICEHEGPSLFDGSYIECKKCQNTYVGNVTLKIADFGLSKLRSQLKDNQEKHLSIQGTLPYTAPEVIRGICLKQSDVYSFSVIMWEMVHKKIPGTGWNRDNIFFEIGNNEFHLEFEEDCRDLYRELFNLCNDKNDPMHRPSFQEISESLSKYQDIVIKERKENTTIPGCREVKESTSQINCILEKLRQRVKEEKRDLETVIKELRPHIEQLMNTKPELRKRSDITKDMIGFPEDVRIGCSWNSSNTMSKLISRNDFIERNKDQILLNKNLIPNRPSLDNINDNDSFNNNTNRDSNVTLTDDNIGDLQRKSAIRNVKISPSNSIGDIYGSVCEKGENYVYDVDCIEVIKYELIEAIPHDKIIGSSTSTINSSFEQSISGDSDDIDKLTATNDFSVNKRSLSEASTSRINSSYSSNNSTPKKHRSHLLNKFKNLIKPNKGCNKNKESSKFYDTSTLSSTNDDIRESQISFDDGRITKTNKYNKRSNTTMSIGNSYIQVHGKGHSRNASSSSTVSDNNIYVNESPESGVWECDSNKCLGKYNLESFTYKQIDPIYYQREKIKKECEKGKDNKFTYNVFRNHDYVSAETTPVIENRKINDNEDKIFEKGYILANQGYKSLIEAGTSKSYNNILDSESNVSSIIKKFNGDSQKPFIPNSLKIHHHNSHKSHSSSPINSIIEPIPTRTTSLDHLTILNGDIEPPEIPSHRKNTLLFSSKIKKDNIENNNIYNNTCKGETYIENESYNEINLKVPQIPNKLPIRSRQVKSSEGIRISHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF67</accession>
    <name>A0A0N5BF67_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF67"/>
    <dbReference type="WBParaSite" id="SPAL_0000463500.1">
        <property type="protein sequence ID" value="SPAL_0000463500.1"/>
        <property type="gene ID" value="SPAL_0000463500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894184" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000463500.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25199" checksum="251A9305FDE83DB5" modified="2015-12-09" version="1">MNTFLTFLLTFLFSLIYGIFEDEPHPVPAKDLSLACDICHVLKVGKDGKLKCVKRNRCCDGLNSYTSCLINPCLHYRKSCKRSKHCIINNCRSSGCYAIYYDENWIEIDSQYCNSQEKLKLKSYQIPKEADGNNRIKIFPQVSMKKFYHDIKKDKPGICDKNLQNEGEILKICTDNCKNDNDCPGQMKCCNNGCASLCTLKYKKVEKNFLNIEIVVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFM0</accession>
    <name>A0A0N5BFM0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HABP4_PAI-RBP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFM0"/>
    <dbReference type="STRING" id="174720.A0A0N5BFM0"/>
    <dbReference type="WBParaSite" id="SPAL_0000478600.1">
        <property type="protein sequence ID" value="SPAL_0000478600.1"/>
        <property type="gene ID" value="SPAL_0000478600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000478600.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26687" checksum="E6C4DECE5730A5B6" modified="2015-12-09" version="1">MKPIKEADLEKLLGIPNVDPDKLKNQEEENVAMVATNYLAQNNSSSIEANMGQHDKDSQYQLHHTSNQQQSILAPPQMQSNNDPSSSKKDLNFAEDYYNSDDKNDNSLQNGEGGNDHQQVQQQSQGTGGSNKKNGNGHGNQGRKRHAPQGKGGNAKKQKGNNENNAQDRSSSQTRGHAGNQRGNMGGMRGGRGGMRLPYQGQSNNWQGIHPPPLLGHGGTFNGNKNNSYGTGGGRRGPGLNKRVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFZ2</accession>
    <name>A0A0N5BFZ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clu domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFZ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BFZ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000490000.1">
        <property type="protein sequence ID" value="SPAL_0000490000.1"/>
        <property type="gene ID" value="SPAL_0000490000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="342"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000490000.1"/>
        </source>
    </evidence>
    <sequence length="1248" mass="141920" checksum="D560FAAC8C23CBBB" modified="2015-12-09" version="1">MAKNKLNMKNKNQMNEKAVSGENKKVQDKIEEKINEKQQCDSGNESNPVTPSHEHGEECINGCENDKLVQVKISLPNNASFEATLSTKEPSLELFQVISEREDCCYRTCYQLVTKGIRLDTFTELEKLVNLENGDVIEFVQSDYSTREARDHVRRMCDILNINDISTYVLNKNGSSFNYMGNMKTNVEPDSKEGQMLAVPYDYVLPGAKDLNYSHLVPDMTNKQMKAFNYVGISPFNPPTPQRKLKGDVLYIYVETLEGKCYNITCSYKGWFVNSTSGYKFNSEQSPQHPSIYHELPDLLMSISLGFKKVWPKALKARIDMHVFEKLEATFPSFNWVVPSFEATQDYFRSEDETQIQKTGFEDLLPGGIRDWNEELCNAKDMPKKDFRERLDKDRLFYKSYSDFVKVAVKGAVAIIDGNVPSLNVSDDFKTQMFLYNSIFFSLGYDSKDHYASFGGNDAAHTISNNDLKGAKAFHALDKDGLYNLGLCLVDYKGYRVVCQSIVPGILEREQDADVNYGSVDFGKTVRCDETFAKPLEEVAKEMNSMPHTIVTVNPEGEEVKTKVFTSIETKGLVGKDGRNYVLDLFRTFPPDVNYIEDAKVTSMCEKNGFPKYCKHKVPCLRPEFIETFINSRTEEFFSSLGSAIKENEILKTSKLAFASILEKLCQGDELETEEQTTEGRKVFKELLKKIGSYSDSSIDIRFNNDCYYPGIKFSEDDDIEGHKDLLAESAEYLAFKVIPTFVQELLDTNPSTTPLDGYALSYNMHAKGINMRYLGYIAMLAEGIDKERFAYDLVVGEILARSIKHVFRNYATELPRSYTGSAIVHFLNCVFGNVEYDSKKSLKVKKGKKRSNSNDNNDSQGWKELTTSDVWKNIADDSKKTFDYSLIYKNFDDLCKHMSIKKNVILRRFSKMVGLQFVAKTIKLDGKKLPFSENDLYNMVPVIKHLEPHAKDAYQFQRIGERLVIEGKIEEAQSYITESLQYMNYVYSGLHLDMAASLKIIAKLDYITNNSSSAYINLQKSITITERVRGLDYLFLIHDYITLSLYAFASKDVGASLQYLYRARYLTNVIFGDGHPILATIDGSLSIILYFNCDYDNSGKFFESYMEVIEKNKLKKNGAEKKGITEVDIKTALICRLAASGYAIRGLFREAIKIEKIVYQIYSSFFGKNHGKVLESGQILKDYTEKAVNLQRKLNDAHGNGADIKIGDIISHDIREITHDKMVGFLNVVNGVYFITQDEINTVSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG08</accession>
    <name>A0A0N5BG08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG08"/>
    <dbReference type="STRING" id="174720.A0A0N5BG08"/>
    <dbReference type="WBParaSite" id="SPAL_0000491600.1">
        <property type="protein sequence ID" value="SPAL_0000491600.1"/>
        <property type="gene ID" value="SPAL_0000491600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000491600.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40258" checksum="5D0D721BCF6962C8" modified="2015-12-09" version="1">MHVFSIPWWIFFGTLFSGLTIIGLLGNVIVIIIIGFDKSMRKSCMNILLLNLAVADTLNLTVSTVEWIHLILKGYQEFIFPPIFCPISRYLECVFLYSSIMTQLIVCVERFIAIIYPIHARRLCTTRNFIKSLISMWIFVFITASPYLFVNVLSPTKKICFTSGLREKWFIAFKWVEFSSLYLFPAIIFLILYSKVAKSLWKNNSQLYEGSRTSCINHGINDTLKMRRNVVKMLVACVIVYFICYSPIQGLFIAKYLLNISLVPPYEFVLIMNALAMTCSACNPLLYTLFSKKFRKRISEFLTCKSCNGRYKFKRMKRNKNGVKAKSKETNVSLSYAYCLENDKNVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGQ3</accession>
    <name>A0A0N5BGQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000515300.1">
        <property type="protein sequence ID" value="SPAL_0000515300.1"/>
        <property type="gene ID" value="SPAL_0000515300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000515300.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="75118" checksum="EC1E1BA54BE5FC3E" modified="2015-12-09" version="1">FGANGHIARDCKNPLPGGVVVDEEYQALMNQLNEANVDPSTYVMYAQQGLVTPTAPTTASPGQFPPAGGSLATNYPGYTPNQNQQIAPGFGFVQNNPQNATAATYPQPPIDMSMFYAPPPPPPPSSGSVMMGYGDSTGGLDSIESMKQAALAYAARQTAANDDEVNRSSQYRSQLSESKKKIASPEQLENFFQDIGLNIIETMEYSACFSFIGRSVERKSFISMLEDYLKSHNVDNVMSILLPIIILRDGSEFFKILEMLSRPVRINGNFFNSFLKILISMEVLQTRMLEKIFKFFERSTSKDEMVKIPCNIYVDLLRGTGKIYEEEKVYNTIISNLRYDKFDTVYRNELASFIYKFIEDDALHNELYRELMKWIKRNDLDDCENFRLALLESIENVQPDPVVAQLECFHLIKKINIFGCKSTIKIVDYTAMMLASDNRDCIAPFLLILRQNFRFEKFKEPADFEEIVCKMFRIIMMLVRASRKIGIRIVFNVLKGSKDKKVTPADFGIVNDNTGEELIYIDGEDGNNIDEEDKVKETALKRRFSEFEYLLSILTVNESFYCHFSKGAAAIWQLMAKNIRHHPELFDEDCKFISMLINCDSFRTKYEKAMKYIAVCFDVVEESIVQQMGRYILVGLDAHSCYDEVYSNLMGKKEKDDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGR6</accession>
    <name>A0A0N5BGR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BGR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000516600.1">
        <property type="protein sequence ID" value="SPAL_0000516600.1"/>
        <property type="gene ID" value="SPAL_0000516600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000516600.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12267" checksum="856EC8D82FCF520B" modified="2015-12-09" version="1">XKSKVVEDGIFCHFLASMVSGLATTIISMPVDIVKTRIQSMRVVDGKPEYSGMADVVKKVISKEGFFALWKGFTPYYMRLGPHTVITFIILEQMNSAYNKHVLGVKGGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGW4</accession>
    <name>A0A0N5BGW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGW4"/>
    <dbReference type="WBParaSite" id="SPAL_0000521400.1">
        <property type="protein sequence ID" value="SPAL_0000521400.1"/>
        <property type="gene ID" value="SPAL_0000521400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894340" evidence="2">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000521400.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10012" checksum="82C6ACE95DF82636" modified="2015-12-09" version="1">MHFIKYFTILVLLAVQYSFQDDTTTYATTPAYMYSYDYGDSSFGTTQESPLDYVNREKRSLKDKLKDVKSKAKNLVGKAKDDSRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHA8</accession>
    <name>A0A0N5BHA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase_M16_M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHA8"/>
    <dbReference type="WBParaSite" id="SPAL_0000535200.1">
        <property type="protein sequence ID" value="SPAL_0000535200.1"/>
        <property type="gene ID" value="SPAL_0000535200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000535200.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18681" checksum="07FAED0499EEC31B" modified="2015-12-09" version="1">MDSQRNTSYTSKMISFPLRSIEKNYAFEELNETGIKIEFVEEGKRNGGLNVFSKIESYGEIEDTDLQKTVAAFLFKNVEKSYRNFSNFISKTKEEFNLTETTLEKIKDTFYQYYGLLFYLKVNICMVNEFHYPETALMPLVMEKKISKDIYDKWPITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHV1</accession>
    <name>A0A0N5BHV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000553600.1">
        <property type="protein sequence ID" value="SPAL_0000553600.1"/>
        <property type="gene ID" value="SPAL_0000553600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000553600.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25707" checksum="577A17279387C1B7" modified="2015-12-09" version="1">MYSLVIWFIIIPFIGNTKGCKIFFLRDAYYELELIINTDIVTRTNLSVYAFVGRSYKHPPSSRIPPHERTRISYLYGVKLFDNKTSTDFFSVKGENSKFESITKRSIYSHPNCNNYTLMKEDLNNCNGPPNFVAIYSTGIKKKNQYEIKNLYIQTVLRDEKDYKGNNIGLPRHEETFDMGEVEYEGTVDTLNIFDKVNGKIKASKRREMDPVDYILMNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHX0</accession>
    <name>A0A0N5BHX0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHX0"/>
    <dbReference type="STRING" id="174720.A0A0N5BHX0"/>
    <dbReference type="WBParaSite" id="SPAL_0000555500.1">
        <property type="protein sequence ID" value="SPAL_0000555500.1"/>
        <property type="gene ID" value="SPAL_0000555500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000555500.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31349" checksum="86219C39196CF514" modified="2015-12-09" version="1">MKYGQLVVGPAGSGKSTYCYAMQQHIRAMNRTCFVVNLDPAAEEFKYDCHLDIRELISLDDVQSDEELALGPNGGLVFCMEYLMNNLDWLEEAIDAAEDDYFLFDCPGQIELYSHLPVMPKIIEQLKVWDFNICCCFLLDTHFVLEPNKFISGALTTLATMVSFELPAVNILTKQDQLNDEEKEIIDDFLENNVNNIIENGKYTKWDIKHKKLTQAIADVLEDYSLVKFQPLNIKDEDSLGDLLLVINNNIQYDENQEVRDIYPEDDDGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJY0</accession>
    <name>A0A0N5BJY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJY0"/>
    <dbReference type="STRING" id="174720.A0A0N5BJY0"/>
    <dbReference type="WBParaSite" id="SPAL_0000624700.1">
        <property type="protein sequence ID" value="SPAL_0000624700.1"/>
        <property type="gene ID" value="SPAL_0000624700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09515">
        <property type="entry name" value="SAM_SGMS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000624700.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54609" checksum="B32D14B94775495F" modified="2015-12-09" version="1">MGKVVQVLSKPPEEWSFMDVHCWLVDQGFSKYAELFSQKHKIDGCTLMELNEKDLKEPPMSIPCLGDIKKIIKAINMLKSSSEYGYDGKDSQSSNPEDPPANLTISSEVKSSFAENDGYIVESVAAYKTISKRDIDTDDLFEEIHLLSREDIIRHVESPDTHSKAIWKLVIAFLYCSLSLWITSFVMVIVHSRVPDMKTYPPLPDLILDNLPLIPWAFEVCELIGVILMSVWFIVLFFHKHRVVIMRRMFSLVGTVFLLRCVTMLITSLSVPGHHLECTAKEYESLSDKLQHAFHIWSKLGMSIQGVRTCGDYMFSGHTTAITLLNLLITEYTPDSWYLLHTSTWVMNFFAIFFILAGHEHYSIDVFIAFYISSRMFLYYHAYAYNSMNLNTTDSRVRIWFPLGWFFEAGGQGRLSNEYEWPIQLGKIVLFFRKSKRSLSPIIKDIDKKFTFNDYDVNPNNKIRNRKNKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK48</accession>
    <name>A0A0N5BK48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK48"/>
    <dbReference type="WBParaSite" id="SPAL_0000631300.1">
        <property type="protein sequence ID" value="SPAL_0000631300.1"/>
        <property type="gene ID" value="SPAL_0000631300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000631300.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35700" checksum="A0BDC1A4DBD6810E" modified="2015-12-09" version="1">MPFRLPTGSHRQANFHHLLRLAHFKDPEEQFREAKMKIEKVRLFQKYPYENNMKVMYMQFHRAVNVASENMQQEFKKRELQHLCVVKKKKAMIKDKEDEINNLKSLLSRYRQCGRALNENIKELESYSQQSKESLLLCQAKLNSTNLKRPRDCNNKINYQKPGFDASQASFNLQKRRKPQTVRRSKSSDLISFERPNTRDSKSKNYLERSIPIFKFSKSSFKFKDSNASESYGGSCAATMVEDVGGTTGLSLCTLILQQCLTDVECNAADVTLSICKLYSFTCVADTTTMTPTTIDGTTTITIKSSATTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKU0</accession>
    <name>A0A0N5BKU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HEXIM1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKU0"/>
    <dbReference type="STRING" id="174720.A0A0N5BKU0"/>
    <dbReference type="WBParaSite" id="SPAL_0000654500.1">
        <property type="protein sequence ID" value="SPAL_0000654500.1"/>
        <property type="gene ID" value="SPAL_0000654500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000654500.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32989" checksum="A35338C9A16AA332" modified="2015-12-09" version="1">MPKKMKSHEGGVPCKVEPSSISYGSLSENDAEDMDVVYQERRMTGSSSKKRNGHPLNNRIITRNGVAIMKRRRNIVLKRNSRVRGSRRNNQDGIYDSHQILTPRNDVTLVVPRAPYNTNSFLADDIEDREKAKSHDSFYINPNYRFRCYSLGAVNLSTSLDNPGSDDTSASSDYEDITEFNREYDNIFMDRLNSLSKTQLASEYITLEARNSELNAEMTNYYNENMFLKRKLKEQGIQYEDLMEEILPRKRTFSGNSDTTDSTLPKTNESDEGTFYDCKFASQSPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKU5</accession>
    <name>A0A0N5BKU5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysacc_synt_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKU5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKU5"/>
    <dbReference type="WBParaSite" id="SPAL_0000655000.1">
        <property type="protein sequence ID" value="SPAL_0000655000.1"/>
        <property type="gene ID" value="SPAL_0000655000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000655000.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18510" checksum="B481992BA9EB7E44" modified="2015-12-09" version="1">MADLVTQLTAPPEDYINDPSIELAWAMKASERASIHQNLLLSCDTKTLKLNKNQDDIYKSFREIFPDLNIEMVTEEQLKGDNKKKWHDFCESFKEIDEYNMGALLRMDVKTIYSPDNTIIVPRIQFLAIEAARNIEGLNDKYKESISRDYQKASSDGTLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL43</accession>
    <name>A0A0N5BL43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL43"/>
    <dbReference type="WBParaSite" id="SPAL_0000664400.1">
        <property type="protein sequence ID" value="SPAL_0000664400.1"/>
        <property type="gene ID" value="SPAL_0000664400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000664400.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17916" checksum="7A6D3DF328C9E387" modified="2015-12-09" version="1">MKVFEILTVFIIISISYIVRICAKTVQLTVHGTPICRHKYSPPEKISNENVTAKLKHNKFSAPLKSKSLPCDKKITLSANVQYSNIRDKAFYVTYTYSNSSTNFTEIIPTDCKKDNVYNGPNYICDFGELNPNKYERERKQEYEDILDNMESGAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNQ9</accession>
    <name>A0A0N5BNQ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ITM2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000753600.2">
        <property type="protein sequence ID" value="SPAL_0000753600.2"/>
        <property type="gene ID" value="SPAL_0000753600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="10">
        <location>
            <begin position="153"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000753600.2"/>
        </source>
    </evidence>
    <sequence length="296" mass="34907" checksum="EBD6F9836EFBE736" modified="2015-12-09" version="1">MEVSETDNINNDTKLTLEEKNLLADATNPNIKVPYSPKMISNDYSDFDPKRMSSGNRRNNEKEFLPKRLIYVMKNRVYHDPRLAQICAMILLLWLLIALLISGILMYRYFIYKPTYCGWYSTDFISNGLPAHLEQNMEIDSDGLYEKIQVPQFGLNRKTIYIHDFRKNVTAIVDVLEQRCFLKPLDHNIIPMPKVFIDLINQLQEAFPDNEKHYPRVVKETYRVGPRISVENLLKLDSVMITRHCLSKDVFHLQRISRSSEQLYYFRRKKRGSPNSEILRFSEYQGNNVIQDEIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNW9</accession>
    <name>A0A0N5BNW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNW9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNW9"/>
    <dbReference type="WBParaSite" id="SPAL_0000759700.1">
        <property type="protein sequence ID" value="SPAL_0000759700.1"/>
        <property type="gene ID" value="SPAL_0000759700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894616" evidence="4">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="163"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000759700.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33787" checksum="1B278D31F1B77B1D" modified="2015-12-09" version="1">MILKYLLRYFFILLVITYFVSCNKQNLETSDCPSLLKFDDDGLHGALFSPNYPSNYSDGDECEFLIKVPENYTIELVVYEFKTESCCDTLYIYNGAGDTLLKVLQGDVAPGTIINSNNQSEVFLRFMSDLTNTYKGFYIEYRGIPVDKIENPTTINPFDKNECPSTTLKESVAGISSPNWPSFYPLDITCEYLLEANSTASYIYLEFITFSTESCCDYVEIYDNNNGDDSSKFMTQVKGTNIVQTVFTSTGPYMFIRFYSDLTNNDKGFNAIFYSVPFPTFYIHKPFEKRNITKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPC5</accession>
    <name>A0A0N5BPC5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPC5"/>
    <dbReference type="STRING" id="174720.A0A0N5BPC5"/>
    <dbReference type="WBParaSite" id="SPAL_0000775100.1">
        <property type="protein sequence ID" value="SPAL_0000775100.1"/>
        <property type="gene ID" value="SPAL_0000775100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894725" description="GDT1 family protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000775100.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32936" checksum="21347E329515F4D1" modified="2015-12-09" version="1">MVNCYFFIFLSICLVLLPQYTLSEKRGSSEELKSVNYDDNFKQVKTVDLHENAKEVDGKKNMDEDNGFISGFTGSFLIIIVSEIGDKTWFIAAIMSMRYSRLLVFSGAISALAVMTVLSVFVGWLMQVVPGIIVFWVSTGLFAVFGAQMLYEGFKMSSNEGAEELEEAQAEVQKSELDIETSNLINPSLEQGMSVGANEKTNSMKNSFSYSTIVFMKAFSLTFLAEWGDRSQIATIALGAVKNALGVILGGFIGHSLCTGIAVIGGRVIAQKISVRTVTIIGGFTFIFFALANIVVKFVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ97</accession>
    <name>A0A0N5BQ97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ97"/>
    <dbReference type="WBParaSite" id="SPAL_0000806700.1">
        <property type="protein sequence ID" value="SPAL_0000806700.1"/>
        <property type="gene ID" value="SPAL_0000806700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000806700.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16489" checksum="CF373CA7340C0044" modified="2015-12-09" version="1">MLFTSILVPGIGGKECNKHIEYRVIGQVVENVKETKVNCTEGYCTHVSVNIYNIFTGYEWGCRSDMERMLGNLAIISPGMTKEIEKIEGTCNNLTSYTSSGAINNVDYEVYVNCFINSSTNRSRLSIANISNLIFFSIPFFIAKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRR3</accession>
    <name>A0A0N5BRR3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRR3"/>
    <dbReference type="WBParaSite" id="SPAL_0000855800.1">
        <property type="protein sequence ID" value="SPAL_0000855800.1"/>
        <property type="gene ID" value="SPAL_0000855800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="245"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000855800.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37103" checksum="A7FA1EF6F24CE215" modified="2015-12-09" version="1">MVSIKDEVVDEITIKLIIRPNLNISDAGDPHLSQLKIEKTVSLNPKTLVKDVCRKVMEEYYLGNLVDDFQVFVQHSNLEYYHLSSFFPSMDAEIGSVGRLFGDRLTIKILIPVKSCGFIRMAIVDRVYENSIEYLLSKTGDVKSELQDTIIQYLINDCSIRYLPLETLLQMDEEITRALQPDVRSMSGDAVPPEDKDDSLKYAVVVGIAHEELGINIDDLQICSSGNSTLSPSKVNREEVPPSTRANRRRAIKYKEEEVAFLEDWYDTLGGTPPDDCILQELSNVLNAISGRSEPNKIAGRNVFNWWKRKRTRERKEFDSISKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRR9</accession>
    <name>A0A0N5BRR9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRR9"/>
    <dbReference type="WBParaSite" id="SPAL_0000856400.1">
        <property type="protein sequence ID" value="SPAL_0000856400.1"/>
        <property type="gene ID" value="SPAL_0000856400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000856400.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="62765" checksum="75F93E84301C15AD" modified="2015-12-09" version="1">MEEKRITYVSVHYVKCTIFSSTNIRLSKINNSRSLQNERYDYRDIEKLEVDISLEGPHLLEENMKEGGKKVSELLRKIPHIKALHLKFLQRPFAEYLFQFFIKEIRCHNISILKVFFNDQLKCLYHNIPTINNSTFFKNFGNLRVVQIVVIYEILHSDIKELIDAVSVIKGVTIEIIHKYSFDNVKECLYKRKCINNNSGCICESKSGVLDIISYVIHKQIYLSIPKTKPNLFNFIEVFPTMTTLDFGFLRKLHIKLFSYIELREFAEFLPHMSNLEVLSLHIQVNTDSMLCQFASIPQMARSKWVKLCPEMNSSDSTLFDNLIIKESKSHSYKSFQNLKKLRTIQLTLDIFNASVGHLVFESYRKNPPIVKKYKRLYNIEIFSFLSKAPRTVENLYLCRIPEFKYLSSYLLNEYFPNLTFLCLGEIYNYEKECLVNLKNLKIFVSHYKNVFVLPENIETCMLCINYYSSNEELQLNRELFSQYYKYLKHFTKEYTLNGSIKGKIFFNHYQDYLSVKRYFSDIEEMAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRY1</accession>
    <name>A0A0N5BRY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000862600.1">
        <property type="protein sequence ID" value="SPAL_0000862600.1"/>
        <property type="gene ID" value="SPAL_0000862600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000862600.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19135" checksum="641B58E55D9D9172" modified="2015-12-09" version="1">MVVGRTAAFAKRRQSFATSHGSHSKTSNAFIAKRTSDNDENESKANLKKSNKKRQSVVLRKNLSTVTRYETIRSSGGSKYARRHSKLTSANTRNSFDFATAVIQAARRASEANPQNRELNSTETSGFQKNNYPLCNNLYENCIEKSEGSSKSNSSSINLEASTYVTPWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS11</accession>
    <name>A0A0N5BS11_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS11"/>
    <dbReference type="STRING" id="174720.A0A0N5BS11"/>
    <dbReference type="WBParaSite" id="SPAL_0000865700.1">
        <property type="protein sequence ID" value="SPAL_0000865700.1"/>
        <property type="gene ID" value="SPAL_0000865700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000051">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="153"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000865700.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51589" checksum="9B2E8760A24E1D86" modified="2015-12-09" version="1">MVKQNKTSNTNKSFEEKNGTIIVSINDPVINELIKQPYYHGFLPREDINKMLKKCGDFLVRLSEPVPGKERAYILSVRIKPQKGSVTITRCLNHFVIKKTPDNRYQISKAAFKSVVELINHYSESKKSVSCGNDILLKNPVGKQPWEFCHSQIKVTKKLGEGAFAEVHLGTYDENLSGRTKNVAIKLAKLEKLTKDQIKEIMKEARLMRKFDHPNVVRLFGIAAGQEPLMLIMELCTNGALDKYLQKNTLDIDRKMNMCCGAAFGIEYLHSLKIIHRDIAARNCLYGGDGQVKISDFGMSVEGTQYKMDPKCRVPVKWCSPETIVSKVYYTESDVYAYGIMVWEIFNNGTEPYSSFSNYEFIIKVIKEDYRMSFPDEMPKNFKECILKRCWEKNPKERASMSEVVECLQRETGICRYEAQKEQLIDDIESKSTHEQRPNNTVDKTFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS66</accession>
    <name>A0A0N5BS66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS66"/>
    <dbReference type="STRING" id="174720.A0A0N5BS66"/>
    <dbReference type="WBParaSite" id="SPAL_0000436700.1">
        <property type="protein sequence ID" value="SPAL_0000436700.1"/>
        <property type="gene ID" value="SPAL_0000436700"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000871200.1">
        <property type="protein sequence ID" value="SPAL_0000871200.1"/>
        <property type="gene ID" value="SPAL_0000871200"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001147000.1">
        <property type="protein sequence ID" value="SPAL_0001147000.1"/>
        <property type="gene ID" value="SPAL_0001147000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF14">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000436700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000871200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001147000.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22542" checksum="C0DD977443800C4D" modified="2015-12-09" version="1">MVDRNGKTKVPGVCADFLPPLDDKMYYSILEKSKHIKEVLNLNDEIIINILDGEKREKVPCNIRNEKTSSRQPVIAKCSVCGLVVQHPSRIKEHSRTHTKVKPFECDICNEKFSRKCSLNLHIKRKHSQVKDFHCTWECGKSFPSVALLNEHVRYYHGGMRRYKCTVLNCGSLFVRRQQFLRHLKNVHNVVNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSS3</accession>
    <name>A0A0N5BSS3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neogenin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSS3"/>
    <dbReference type="WBParaSite" id="SPAL_0000891500.1">
        <property type="protein sequence ID" value="SPAL_0000891500.1"/>
        <property type="gene ID" value="SPAL_0000891500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000891500.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23624" checksum="1C1A8A5B1A370843" modified="2015-12-09" version="1">MIIDEIPPEENVSKSSIYNPGNSLFEDCKDIDDIDIGSNVSQNHVYSQGTSLFEECKENDSDIDANDFDEYPMEPTSNQIYPVNTSNQYYQVTSPTVSNVPNSAYVTVNNDNTSRKRLNPSNRPQNSYTPQSPSSSTSRVPSSKPYYRQPPQSQTPPPSRSIRYNNTTSFNNPSFQNYTSNAKQTQNFDLERELKEIDEMNDAIDKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSW7</accession>
    <name>A0A0N5BSW7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RLR CTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSW7"/>
    <dbReference type="STRING" id="174720.A0A0N5BSW7"/>
    <dbReference type="WBParaSite" id="SPAL_0000895800.1">
        <property type="protein sequence ID" value="SPAL_0000895800.1"/>
        <property type="gene ID" value="SPAL_0000895800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RLR CTR" evidence="1">
        <location>
            <begin position="844"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000895800.1"/>
        </source>
    </evidence>
    <sequence length="1021" mass="119965" checksum="163CE328DD891307" modified="2015-12-09" version="1">MAFESDFILDINDLPLSHFYTYKYEIIEYFMLPNSDEWLRKLISKAKTEHDILEITKICTKGRFYTCKKYYEMYDPHHDKEFIMNALKVLPVDIKNHAILKDIPQFSLSLYSQLFLKKYDERVFEKILLCTKWHDIYERFNSNSKYQVFCEKIKKEFDRYPGCADYLGCLFLRELPFIDYFKNIENNWYYDLRVAYAESDLNRAILMQFNPDFFPFLKGIKMKREAEEKKRRRLLGESLQIDNIKLPDVPKTLRIQSKYLDYLPEASKKAVGTLEASKKAVGTLQPLKSYQLELVSSVDNDTKNHILWIPEKAGKISIISHIANNHFQLHCKEQQLTRILLLVPHFKYVHDYKNYLRGLCSDLLNVDGIADYERSFTNINSILAHDFVIMSGQMFLDLLKVNNPDYKLYLQDFSLIFMDHCEISLEGHPYCSFIKFYNENNYKKPKLIGITESLGRHLENNEDNSMNALCDLCYNFSASKIDIVKNNADDFYKDVSKGFQEIVICLSTPNFFIQVINRESYTIEKEISNVLSKLLGDENFEELKFPGIEDTGTYYGYCDNVIQIIQQQSDENIKKSLLSAIDFLSCLSFTLSIHNVIPTEYSFENCVSTLRRWSQNCDESQPLSKKLLESYNRILQSRNDPKYKTIIDEKKLSLVRLEHIIKQSIKKNFKSKIFIRVSSEIVALTLDRWLSNNDFMEKYNCIHTYVINVSDQDPQNEEEDTIYHDRIRKFKDGKINILISTDVSQNDIDISTLDCFISYNCPITYTKYIGNFKTTDGYPKNMALIVTEGLLELDDQKLFEKDRMTNCIVRRLRKMSDYEFQSLIEERKKSNDIRNKNYVEVMKEYCNKNENAVYDISCSSCMTYLCSSKDVGIFENITNIIVTPDIWSKVTYVIDKHYKYTRAFMRVGLVCCKVCKKNNGVDDIDENNTLGTVIKLRQGFVIKLAPKNLFFTDTVTKEQHYKRGWNAVETNLSLGNEISEDDFLEYCQESMCRDPEMHLIFMKKMSNYISVCRSSVYHKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUV7</accession>
    <name>A0A0N5BUV7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUV7"/>
    <dbReference type="WBParaSite" id="SPAL_0000962500.1">
        <property type="protein sequence ID" value="SPAL_0000962500.1"/>
        <property type="gene ID" value="SPAL_0000962500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000962500.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26032" checksum="5ABB631D5EA39BA9" modified="2015-12-09" version="1">MFFKFSDTAYGQIRRIFNDEELAEELRKENFDLGIVEAFHFSILGMFKVWGIKAYVTGFSMSLEDTMYKYFGMPFPASFIPNHMSPFSDKMTYKERFQNLFAHYIGETVYYILNPKTALQKEFDKKYGVGFYNSYNAIGDSSFIVINSNPFLDIPGPKTPKMVEVSGIGIKDTKPLNEYWNKILSLRNKTILVSFGTFTKATYMPEDLKNGLLEAIRKLNDITFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUZ6</accession>
    <name>A0A0N5BUZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000966400.1">
        <property type="protein sequence ID" value="SPAL_0000966400.1"/>
        <property type="gene ID" value="SPAL_0000966400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000966400.1"/>
        </source>
    </evidence>
    <sequence length="40" mass="4605" checksum="2467BE461BCC8DF0" modified="2015-12-09" version="1">MDQNMDPDNFGNNYKIIKSLNFQFLAGGYGNNMRMGHGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV43</accession>
    <name>A0A0N5BV43_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV43"/>
    <dbReference type="STRING" id="174720.A0A0N5BV43"/>
    <dbReference type="WBParaSite" id="SPAL_0000970900.1">
        <property type="protein sequence ID" value="SPAL_0000970900.1"/>
        <property type="gene ID" value="SPAL_0000970900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="342"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="718"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000970900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="102797" checksum="E21110DE88EE10E2" modified="2015-12-09" version="1">MNRFDDKKRVGVSSVSNAKILETLAKKREQLKLVLNNSSKGKSSSKCQQKRSVFPEKKQKSTKLDDGEFIAEEDDDYDCYISDEDRPEEKMEDIVADSSGEEIVENFVEPVRLKISKDKSGEIEYEVTSELPIHAIQSSDDEDMQPVKKNLNKRKLTIDSSDDDRVKSPIKSKKKEGSRKVKCLKTEEVDDDVNDKNYSGMFNNCSDSDDEQNVYRTYSDSELKQKTIDFFNHASIEDIRSTPRISDKMVNVIMSMRPFSSFDEFQKTLNAIPRGNQAIEVYFDYLENRGIIEKVLDDCTGKAKEMSKRLQDMSTKEVIQQPASLTNCVLHDYQQIGLNWLVQMHKLGYNAILADEMGLGKTIQIIAFLTYLKESGVNGPHLIVVPSSVIENWQNEFSKFSPTLKILCYYGAMDERKRLRREAVKGTKNIDVLLTTYNMITSKEEDRKFFKAFSIHYVVYDEGHMLKNCNTTRYRSLMKVKGKRKILLTGTPLQNNLIELISLTYFVMSKMFLNYCDDIDQLLGQFQIRTQCGKRTNTVTSLKKEFEKENSEEDRTPLTVDELYESHKIEQAKLILSPFMLRRLKTEVLQSLPKKNQEIVYVNLKPLQVEMYDHCLSDIRRAHLTGDGSSVGGLMQLRQIANHPLLYRWIYNDGLCHKIAELLVMHNDTYKKKNPVYLAEDLGFMSDMAIHKLCLTTTQTTQYALEDSKFLESSKIDALDKLLPKIKSSNEKVLIFSQFTMLLDILEVYLEIRGYHFRRLDGSTPVMERFQMVEEFNKDDDIFVFLLSTRAGGLGINLTAANNVIIHDIDYNIQNDKQAEDRAHRLGQTKEVNIYRLIAKNTVEEPMLTNAENKLKLQENVTGDNSENTIDHKLVEILLKDAFEKKDSLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV76</accession>
    <name>A0A0N5BV76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV76"/>
    <dbReference type="WBParaSite" id="SPAL_0000974100.1">
        <property type="protein sequence ID" value="SPAL_0000974100.1"/>
        <property type="gene ID" value="SPAL_0000974100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="154"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000974100.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34502" checksum="A9DB12DC7B673D03" modified="2015-12-09" version="1">MGEYNSENNFQAASKPEVYKTCLPSLDNPKSKINKRKVKFSEDDISLTFSVYGKPSFKCNGHKVPSLKKLTECAVNKTKIISGSNCQRVFNGLGSSACSHDKSNHKNVCQEPSIIFLNKLDPKFRQHSFSNKVWVNIWRNNYEYRCYSHRNFYLLRQRFMLEINTYRSAHRSPPLTEDYYLSKVAQDRAEKIASSGKVNTEKNEDYEEIVGVTDIFMAPFMVKQWYQEVNKYNFVTPFLTRNSKNFVKMIWKKTTYLGIGIVKRNCDLYIVLKFKKRKRKLIGLLSNVRTLKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVL8</accession>
    <name>A0A0N5BVL8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVL8"/>
    <dbReference type="STRING" id="174720.A0A0N5BVL8"/>
    <dbReference type="WBParaSite" id="SPAL_0000987400.1">
        <property type="protein sequence ID" value="SPAL_0000987400.1"/>
        <property type="gene ID" value="SPAL_0000987400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="41"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000987400.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31822" checksum="1182F991C27D3E38" modified="2015-12-09" version="1">MNLDILSATIALVSSLLLSFYLYKTTKHTKFHSVDKKCSIKGLKNLGNTCYINALLQALASSKYFTEWIMGVPINESSAEVPFIKSLKEILIKMQECDNDNLSASEVISALSFHRWNLSIGSEQDLFELLNVFYTTFEEEINTIANSTNAFKRILTSSLFSSTVKEPINSLVTRAFTKNLSYKQLPFFGSICTTIRCCDKNCSHEEVKIDPVGVISLPIPRDTFLNTLSLEFLLRNYFKSEIINDASCDKCIKEKNKKASGIYKKDAFGKVSLIKINGNFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW59</accession>
    <name>A0A0N5BW59_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Tu, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW59"/>
    <dbReference type="STRING" id="174720.A0A0N5BW59"/>
    <dbReference type="WBParaSite" id="SPAL_0001006200.1">
        <property type="protein sequence ID" value="SPAL_0001006200.1"/>
        <property type="gene ID" value="SPAL_0001006200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000102">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="51"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001006200.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55388" checksum="9B049E06BD8C401B" modified="2015-12-09" version="1">MFLLTTFSRSLQASSKISACVSRFATPNLITFEATRCLAVPGGKTSFKRNKPHLNVGTIGHVDHGKTTLTAAITKVLAVQKGAKYKKYEEIDNAPEEKARGITINSCHLEYETDKRHFAHIDCPGHADYIKNMITGASQMEGAILVVAATDGPMPQTREHLLLASQVGIPKENIAVFLNKIDEVSDNETKELVEMEIRELLNEFGYQGDSLPVIYGSALSALEDKNPEIGVESIKKLLNVLDTQFVIPKRESNTEPLFAAEHIYTIQGRGTVITGKLERGTLKRNDKVEIVGYDREGIKTVVSGLESFRKTVEVAEPGDQLGILLRGIGPKDVRRGCVLLPQGHKHVVTDRVKAQLYILKPEEGGSKMPIANYFTEHVFSLTWDNSAVLKVIGKDFIMPGEHGEVELLLSCKMFIEPQQRFTIRKGNTTIGTGVFLELLEPQTEEQKSTKERRKLMKAEMERLGFNPYGEMMERRVKPDYTNSPKDNPMAKAFETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWR4</accession>
    <name>A0A0N5BWR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SWIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWR4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWR4"/>
    <dbReference type="WBParaSite" id="SPAL_0001025400.1">
        <property type="protein sequence ID" value="SPAL_0001025400.1"/>
        <property type="gene ID" value="SPAL_0001025400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="4">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="322"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001025400.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57530" checksum="A2212C314A301D99" modified="2015-12-09" version="1">MNGEPPISNLEICNFINKLIERNGLDLLTSSFIRKQLKEKYKFNFDPFKKLIDSLISGVIQKRHEKENDNDSHTHDSTDDEIDFSDIAEKYSTKNETKEKSPSPKSFESSESSEDDGPEDRDYVKKKSKSSKSRSSKTNSVDSDNEVFDGNDMASAIKRRRAAANIKKSVIANKTKSSSSATKRSVASSGFTKIMMVSDELFAITTKKYMRRSDVVKYMWDYFKSNGLIDPNNKKMVLCDEKLKALTGVSTFQAFGMMKYIKNHLKDAEDLDEETRSIILKDLGVEETKIDKNDKTESKKKSKSVVSDKSGANKVPKKGKSSFSRFCVLSDELSNLTGQRYMTRSDVVKFMWDYFKGHNLMDPKDKRMVIVNDQLRPIFPQKRIQAFVMMKSLKNHIKDPNLLGPEHMEAITALHNELEEKRKKAEEVNSIVDVEEKHSYINEERLKKESENIVEKNKRPNVFSVGSGYQSVESDDEEDDDDPYGSSSIPFKVSKIEENKSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX25</accession>
    <name>A0A0N5BX25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX25"/>
    <dbReference type="WBParaSite" id="SPAL_0001036150.1">
        <property type="protein sequence ID" value="SPAL_0001036150.1"/>
        <property type="gene ID" value="SPAL_0001036150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001036150.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8862" checksum="3842CE0694093014" modified="2015-12-09" version="1">MSDRYRKICNVFLLFLSLQFGGITKWIFCDFPTMHLSRLAMSPLTNICKSVYMDSLFTRKKKVTSIIRIQKHNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY59</accession>
    <name>A0A0N5BY59_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BY59"/>
    <dbReference type="WBParaSite" id="SPAL_0001072000.1">
        <property type="protein sequence ID" value="SPAL_0001072000.1"/>
        <property type="gene ID" value="SPAL_0001072000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="31"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="6">
        <location>
            <begin position="725"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001072000.1"/>
        </source>
    </evidence>
    <sequence length="1259" mass="143346" checksum="E8BF6FFA0E9224CC" modified="2015-12-09" version="1">XISNISAQNVDVDSYCDSFTFPNMGSVLDNRFIVWKSEGSNLYLQEYSTERDLKSSSLCINVAPSVIVPGTQISFSQNCLTLTIVTQFAICSLDLPLSEDMVDELKCTSALHYFYISSENVLKRVYNFKNQAAFAVKACVASPTGFSPHVVVCLNVKNEVIVIKVPKAGVPNGKVEETNLSSTGFLEYFTRPTENKKVVDLHAISTSEDTYVLTLHNEAMVKLWSTNSCTVVDRINVCEYFRTSLSSINNIYIKTATLNKEKFAVIFARSICEKSFIGLFSICSDRFDFCCQSFITSQSFDHQDFIVVPAGKTFDLGVDLYILSRKPNNYTVDDDIPVRQPYIIEKCWINTKIPHETAETVSVIPVVNAYDVPFLNDFTMEDDSSEQTSFYKRVVFDKEVFSSEVVQKAVAINCKMNKKDVPLEDYLALRSLIKSYIKSPKFKQDAMGTPGQKRVTDNLVSHNMEIALLNFWKKLLQTCYELQYVANEAIGLWKAENVGLVGSILNNQLTVISNGDYVLSQIVTNVLKKSGLKSIPFSQLAKNIEKQKKGLVAVNVIEKSKNVKFLETLHDELSQSLYLLTVEPSELTTVISTSEYIGSSFTVELLSSTLRNLIGGRTYFASRLLDIYKFIPKCQGNKLVKENETIKKQLDQIRNLYGVLFQTLTLPLRIGRESHSPNITLSTSFFKYMQKHKPTLMMKPMVFPESTPFSLYLSNVLYATVYSMYPASLSSAFLKYFIATDKFEYLVDFIGKCNNQAPELKYSNLLCNGLACVASGKVSKAFNNIILALNGINTKDLALNNLLKQLMPSVEYGESLVYIEAIELLIRYFMFKNYHEISIQLGKYATESVDLPENRLSSVYNLLFSVYLRKGDFLSSLECLKNISSADDRSKSLRLIVGILMEPKNRPSFISLTTGQLSLSIMEYLEERANDCDDLMTAGDDYLFNVAFMARRTKYLRSAYNMYHYSCKLGQSIDSWQQLQKRCKALSEAKHLLSLSSEEKYLNVKEDLSVIYSRHCLNTYKVTEEDIMKQLMLSEARLALMDIYQTNSIPPEDKDILERELVNHNLFDMAWTIIMYFGTSPKRFFKTVTEQCIIVEASGSDTPPEWVLHNIKNLKDCIEMEGRHYMILKCYLEQHLSANPCDSEVLRVIFYEFLRYNFPAPEWFVEIFTTKNLPEYLRCLLEYNEIEKVHSTLLTAIDKAIHDVGVHKKHNPILPVTVIEQFLYLAIKGGFNKNASDVEAKVLEYFKKVRTIQTALKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYW2</accession>
    <name>A0A0N5BYW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SPT2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYW2"/>
    <dbReference type="STRING" id="174720.A0A0N5BYW2"/>
    <dbReference type="WBParaSite" id="SPAL_0001096100.1">
        <property type="protein sequence ID" value="SPAL_0001096100.1"/>
        <property type="gene ID" value="SPAL_0001096100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001096100.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37739" checksum="0BDA067E73CDC93E" modified="2015-12-09" version="1">MDAFFADILGDAKAVSQKAGTTIRRNVGDDFRGREKFYSGLIKKNTNLCNNNVTELYSKGGKGYENAKSSISKTTLPTKSDKSTQGQNLSFNELCQLAKTNKKPSDNRVRKTSLKKDKNLDEINKNITSPPKEPKVPKLIIRKTDYTIKSKESDVPKHKEHSTKSKMENMHVKQKPSDKEISSKDRNKHISTTIKRKAEDSGLPSKSITTKVAKIPHKSLDRTYIKDKKDYKESRHLKSYAYELTEDSEDSMDDFIDDDNDDLPTRTEFEEALRSVSRYDKDRWRKNELSIKEDKMTSSFSDIRKEEKKSLKIALKEDLKEKIKGARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYY6</accession>
    <name>A0A0N5BYY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYY6"/>
    <dbReference type="WBParaSite" id="SPAL_0001098350.1">
        <property type="protein sequence ID" value="SPAL_0001098350.1"/>
        <property type="gene ID" value="SPAL_0001098350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035126">
        <property type="entry name" value="SCVP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17619">
        <property type="entry name" value="SCVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895191" evidence="1">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001098350.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16455" checksum="297480F837A11F1B" modified="2015-12-09" version="1">MFTNISFFHILLIYISTIYHSVDGESINYHEVNKLIEDESYNTINKESIVVIFSTYLSEIPHNKIKLLVGEIEDLVEENVRNHGMGISYFGNISINTYLKDEKLMIHYRTEEGSDVCNEFEKIITDVIENHYAIKNGNVTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD5</accession>
    <name>A0A0N5BZD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZD5"/>
    <dbReference type="STRING" id="174720.A0A0N5BZD5"/>
    <dbReference type="WBParaSite" id="SPAL_0001112600.1">
        <property type="protein sequence ID" value="SPAL_0001112600.1"/>
        <property type="gene ID" value="SPAL_0001112600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001112600.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="74749" checksum="C58541E376471158" modified="2015-12-09" version="1">MYPIFYKNIFNFNVFYSKVEVHDRKINKIIYKNSNCFFEKFNIWNDIVYNYVKPLKKFEKCKKIHDKKYYKFFNEVITVMKDDLHCYCSCMYTKNSFELNATQYILIEESIKLNCDIFHLRCYNLSGKIIYDDVYFHINKLYKIPKESTPFLEKNFSIPIRNKRYDVHIYVIDSLSHYHALRALPKTRKFLKEKFNGIEMEYLNAIGADSRHNAYGFLLNKQNIDVDDFFFLSKTKKSDFGDLDLCKIHLDNKTYIQEYYRRMGYVTLSAEDFEHSGIFNYPECVGFKKEPGHHTLKPLQVLSLHPIMSKLVKDKFEEKCYHHGFHMMDYMSDFLQKYENNIKMSLIWQTNLLHDEINPIFAADETFYKFLKKNEKHYKNSFNILMGDHGYKMSSFSLSDIGRYEQKNPYFLITIPEELRSNKQLIKNLKENSKKHISHFDIYATLLDILTNAAKDGFKMLDKQRKFPIKNDTIKGLSLLRPLPYYNRTCYEMFIPPQYCLCKPKFELLPSSMVKERDNIEKNFIKALNNKLILGNLTDKCSEMKLDRSEKFTIQFARNGNSKIVYQVDAVTIPGKARYQAMMNKNFEILNNEIIRFSVYKHQAEPCEKTSFYRIYCYCKSLLTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZI5</accession>
    <name>A0A0N5BZI5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZI5"/>
    <dbReference type="WBParaSite" id="SPAL_0001117500.1">
        <property type="protein sequence ID" value="SPAL_0001117500.1"/>
        <property type="gene ID" value="SPAL_0001117500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001117500.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14285" checksum="71A81DBC1FE47D29" modified="2015-12-09" version="1">MKNPVVATKVNLYLYCLCRNEKVLLTMESIGNDGALIESYFYNKEESCDDTLNIFAQISANYLPYLKITLNHTCFPRAYRPVVTFNAFQQCERNELEKYFFGSINSFVTLNCYETKFLKYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1B3</accession>
    <name>A0A0N5C1B3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1B3"/>
    <dbReference type="WBParaSite" id="SPAL_0001179000.1">
        <property type="protein sequence ID" value="SPAL_0001179000.1"/>
        <property type="gene ID" value="SPAL_0001179000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001179000.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39601" checksum="28993F3B4D7BEF0E" modified="2015-12-09" version="1">MDEYNYNNTDEYNFNYTENYDYYYNFDKFDYVAPAPPNPPKLTKIEIGLIHLILPIIFIILQIMILVVFYRHSKNFESMSYKIMKHQGQILLIQQLGHFCTSYIIIFSINPKSLFVSVIGSMINGCYISNVMFILLLTINRLLIMYKIDSFPKYVDKIFRFGILLCYLCAISFFIFLMLPSYRIGFDLTYFEWYSSEYIDRHIGNQLYIVIQTQIVLFTLGIASILYLLIFLRIIFLRLQSRNSIIIPEDAKFLLYAILNFFSIVFLEIAWSKLSVYFSYSDGLVIVPQILYIFVSGSNTIFTFCFVSRVRKNIFHSIKLRKQITTTKIRIIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2E5</accession>
    <name>A0A0N5C2E5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2E5"/>
    <dbReference type="STRING" id="174720.A0A0N5C2E5"/>
    <dbReference type="WBParaSite" id="SPAL_0001215500.1">
        <property type="protein sequence ID" value="SPAL_0001215500.1"/>
        <property type="gene ID" value="SPAL_0001215500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="435"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001215500.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="79680" checksum="FC13D2FC64131E5A" modified="2015-12-09" version="1">MRGGIITTVSWRKNILAFTNCEGTRIYDFRINQIVTKLDVEPDISRSPLLTYQPIHLWLNDKTLIVGWLNCLTYYKMREHNIVKGIEILKKVDIAKNYKLEDNFMIGGISYMQNDIISEKNPEIILYGMYKNDTLNRYDSTTSLNAPAPSIVTTNGENFVGKVNVKIIKCLTRTEFMVTAEDIIDMNGVLPNQLHRLKMFGMPYDKEYYLLGDRCLIKAIATTLNERLDWRVENDLLFEAVEFARQYKSLLDRESVIHVGRKLMEKLLRDCDYITASDHLSMICNKDKSEWKYMFNIYRMEGILYLFSYAMSNDKPILEKEYYQEVIEDALNKNATIFRRIVETWDKSLYNYKSIIEKLKLILSKIPNDNTPEVNVIRKHFLLSMARLSTYDKDYELAADIYINACDKFIFNWIGQNNVYSVIKERLPELMNISINDTIQLIFDNEADPKSVLFELRGYPDYQLDFLLALFERGDGAEYGNLAVELFVRCRKEKLLNFLQTNDNYIIREATNICRREKMYEELIYLLSRSGFESLKEAIEIIVNEFNDINRAIRFCKENHGDGELWGYLLSFCNQTPQIVKDILEEAGTSIDPLTIVENIDEKLEIPELTLSLKKLIKACEIEIDNMELGLKILTKDINQKYDSCISKKPAFVNIVPGTNYDEPIVVTFDDFNNSVEDVGDFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2N0</accession>
    <name>A0A0N5C2N0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C2N0"/>
    <dbReference type="WBParaSite" id="SPAL_0001224000.1">
        <property type="protein sequence ID" value="SPAL_0001224000.1"/>
        <property type="gene ID" value="SPAL_0001224000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001224000.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="46156" checksum="C89A3F2C2EBFD508" modified="2015-12-09" version="1">XQTIFKIYTGTLLERIQDKIENCVSSSQAGFFRKRNTLNQILQFCTIIQTCREYKKDLYAIFIDFKKAFDSVNHSWLLYSLPINDFDEELVKRIEALYRSPKATFSTGINNSYTTIEVKSGIRQGDTLSPKLFILLLEIILKNAQHDLDDCFKNEESNLVKVMIDGTPTVSFKLEFADDKVIYTYDQKLTEKIAHVIEYHARKTGLELNKDKTKIMATQYKKKLDNPIYEVVSNYKYLGRVVSMDLNGDNNDFNERAKATWRTRFKNKELLNRADYKNKLKIYNCIIRPATLYSIESMRPTIMLINKFVSLEKKVLYSIFKKEIHLAMCIKDIILDRMEKARKPFDVYVEKDWKRPVGRPPKRLLSLVPDNSATRKQHDRKAKSSLNVNIYKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2P6</accession>
    <name>A0A0N5C2P6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exported protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2P6"/>
    <dbReference type="WBParaSite" id="SPAL_0001225600.1">
        <property type="protein sequence ID" value="SPAL_0001225600.1"/>
        <property type="gene ID" value="SPAL_0001225600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895344" evidence="2">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001225600.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14309" checksum="98893C714DF418A2" modified="2015-12-09" version="1">MNFLKYLIILGLFTIQYSVQSSASSEENSSSVSDTNENHENNSELLTEAEDESDNNALTDLSNDTMSQEIEKTDSKKKSGVKRFFSDVGKKAKKIIKSDTTKKVGKGLVKGGMKLVEALMNSSVCNIVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2U1</accession>
    <name>A0A0N5C2U1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2U1"/>
    <dbReference type="WBParaSite" id="SPAL_0001229800.1">
        <property type="protein sequence ID" value="SPAL_0001229800.1"/>
        <property type="gene ID" value="SPAL_0001229800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="49"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229800.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35905" checksum="DD2975290044C7D4" modified="2015-12-09" version="1">MENSGYYQGDIKLSKLQAEYLIDTVAEIAEGLGADVSDIIGDAETRKKRKIDTRPNFIWDLKVPYVVDYRVDRNLIRKALDKLQSETCLEFIEYSGYIPSGEAGLKYFPGDGCYSNVGRQSLNELQEISIGPGCNFIPTIQHETMHIEIKYLKILINNVKDFAIENFLKLQLTDALDYGVPYDYGSAMHYNSHSFSKNGQPTMLPYIPMYEKTIGSKSEATFLDIMVLNLYYCEDICLNRITCKNNGYQDPNSCERCKCLKGFTGRDCSEIERNSLCENQELFADGTQKLLYVDGEKDCVYHIISKSRNKFRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4B9</accession>
    <name>A0A0N5C4B9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4B9"/>
    <dbReference type="STRING" id="174720.A0A0N5C4B9"/>
    <dbReference type="WBParaSite" id="SPAL_0001280000.1">
        <property type="protein sequence ID" value="SPAL_0001280000.1"/>
        <property type="gene ID" value="SPAL_0001280000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF47">
        <property type="entry name" value="ZINC FINGER PROTEIN HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001280000.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57560" checksum="79DE97BAB301A376" modified="2015-12-09" version="1">MPYRSELKRPDLKGQFPCSVCGKVFCHSSSLSRHRMQAHFKSYTCSQCNQEISSSETLRSHMFRIHQISRMFMCRCCNWAFADKTSLHIHMQSMNKDGNPGDVYVLARSSTEAGSFRNEMSSDGESRTSNASSPLTMRIQSPAEASEAKGTLPFSAENLGLDFGKTFFGNDKISNNIKSSIFPQFNEGMDMLMKLKNQQPQIGKTPTVQDLLGQNSLLNCWLATNPLCQNNIFDLSNPNLLNLGKLSSLPVSGKRPEGSVTAEIVNNGNNRKDEISVKTEECNSESGKSDILENSPSKTSPSFLDNLFNKKLAVFSGNDDNNQSTSRTNKRKARKPQQLKDTSFNSSNGDDELEPQAKISNLSYLVEHLNSNSKNDDKLNENQEQHSPAISDSHTCESGQNNSTNSCSLDKCDNCKSVQKQNIVLQEENNKVRRRMSKIENAVYKFEKAIKEYSNKTLPENMKSEMINLVDTCFKACTDDETISSSDNYDSSESTELLGSGIFGAPLFTPLNKISSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4H4</accession>
    <name>A0A0N5C4H4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4H4"/>
    <dbReference type="WBParaSite" id="SPAL_0001285600.1">
        <property type="protein sequence ID" value="SPAL_0001285600.1"/>
        <property type="gene ID" value="SPAL_0001285600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001285600.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9605" checksum="5B52094EF15E219A" modified="2015-12-09" version="1">MHKNIRAIRISNPSIETLHFLFPCAFFKALPTPRATPAPGCPRCNLIHSLPTPRATPAPGCPRCNLIHCPCHSWKHGYSPVYFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C530</accession>
    <name>A0A0N5C530_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C530"/>
    <dbReference type="WBParaSite" id="SPAL_0001305900.1">
        <property type="protein sequence ID" value="SPAL_0001305900.1"/>
        <property type="gene ID" value="SPAL_0001305900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001305900.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36225" checksum="E5B9B10C35B3683B" modified="2015-12-09" version="1">LKISKETCLKFKQTKNPRKALFSYQPGPFYETNLGKRREIPHRIFVAKGKEEIGKTIRETLRALGVDYEHNRYDRDKYIIIHRNSIKQRFLKYFIVKNSTSTFNIGYDYRSVMHFSEDEYGIFGRRVITAKNKLMQNLMGKTQDLTFYDAKLVNKRYCRFPSQIHPPCHNYGYSHPKSPICKCPSFADGIDCTGVIANNHFCTAGNHFYAGLVTSTTDLKVGGNCTFYIHTDYGEKIRLKLLFHNNRRRHRTCKDFRSVEVRYKSDLAASGILFCPDNTPILIKSEAHLVIIQSHFPPEQTKLRIIYKQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5K8</accession>
    <name>A0A0N5C5K8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5K8"/>
    <dbReference type="STRING" id="174720.A0A0N5C5K8"/>
    <dbReference type="WBParaSite" id="SPAL_0001323500.1">
        <property type="protein sequence ID" value="SPAL_0001323500.1"/>
        <property type="gene ID" value="SPAL_0001323500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF16">
        <property type="entry name" value="FMRFAMIDE-LIKE NEUROPEPTIDES 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895397" evidence="7">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001323500.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19802" checksum="1DEAD8BB1A1177AF" modified="2015-12-09" version="1">MFMRLFILLVVACIATAVFGGDEEKYSPNTSSVSLNILPDQFLSDVEELSQYGDEINKEDDEGIEKRAPMDRSSMIRFGKRDQLDRAMVRFGRSPMGRSSMVRFGRAPLDRSAMVRFGRAPLARTSMVRFGKRAPLNRAMVRFGKRAPLDRAMVRFGKRAPLDRAMVRFGKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6S6</accession>
    <name>A0A0N5C6S6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6S6"/>
    <dbReference type="STRING" id="174720.A0A0N5C6S6"/>
    <dbReference type="WBParaSite" id="SPAL_0001364100.1">
        <property type="protein sequence ID" value="SPAL_0001364100.1"/>
        <property type="gene ID" value="SPAL_0001364100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001364100.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25880" checksum="764581FFC9445A56" modified="2015-12-09" version="1">MEDVEFIKREELLKSNGLISNDELTIICRAQIYKHFEYENYGFKERSIDDQLSQLKLDNGETLDSANLPDFTIKVGGTILKANKKILASKSNVFYDLFNCKPKSLQIPIVEINKYSVEAVKLMINYINGDDISGIENMASEIIAIADEYQLDILKYKASLYLSLNLTIKNVCERFMLGSKFSSKQLCASCRTFITNNYEALIQNKNWKNFVINNLQLVEKLSLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8G7</accession>
    <name>A0A0N5C8G7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Decaprenyl-diphosphate synthase subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8G7"/>
    <dbReference type="STRING" id="174720.A0A0N5C8G7"/>
    <dbReference type="WBParaSite" id="SPAL_0001421400.1">
        <property type="protein sequence ID" value="SPAL_0001421400.1"/>
        <property type="gene ID" value="SPAL_0001421400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421400.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45179" checksum="F0569030CF1AF802" modified="2015-12-09" version="1">MEFVKRAGTTFSSSPILFLKNYSSFIGGRSNIHSSWIKYGSKAAASQQLETTTNNLELPDFIREKLDDLQSEVVVSLLTHDNKSIESVTSPINSSIEKGGNFRRNLESMARHYFNKKGKLFRPKVSLMMANAMNQHTGNGELISLNQYKISIVSEMIHTASLVHDDVIDKSDVRRGNPTINALWGNKMAVLVGDYILAKATQQLCSIGDPLVISTMAKIIEDLVQGEFMQINGYNSSNENNAEERFQHYLLKNFYKTGSLFAHSCKSVAMLAGCCEKDQINAYEYGKSLGLAFQLIDDVLDFSATSDTLGKPAGNDLKQGLATGPVLYAAKKYPELNVLINRNFSQEDDIKKAWDIVMNSDGLEKTKELAGQYCLEAVKIARSLPNNFQMSERLADVAINQINRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8H2</accession>
    <name>A0A0N5C8H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8H2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8H2"/>
    <dbReference type="WBParaSite" id="SPAL_0001421900.1">
        <property type="protein sequence ID" value="SPAL_0001421900.1"/>
        <property type="gene ID" value="SPAL_0001421900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421900.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11930" checksum="44F373B91822872E" modified="2015-12-09" version="1">MSKEIKNRNANNKTGTKKTISKKKKDPNAPKKALSAYFLWLNDNRETIKKPGMGVADVAKAAGLIWREMRAEDKAKWEKKAEDDKRRYASELENYKKTKEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8I5</accession>
    <name>A0A0N5C8I5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8I5"/>
    <dbReference type="STRING" id="174720.A0A0N5C8I5"/>
    <dbReference type="WBParaSite" id="SPAL_0001423100.1">
        <property type="protein sequence ID" value="SPAL_0001423100.1"/>
        <property type="gene ID" value="SPAL_0001423100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF139">
        <property type="entry name" value="SEMAPHORIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895577" evidence="3">
        <location>
            <begin position="19"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="4">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001423100.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="76165" checksum="567FF1E275461B05" modified="2015-12-09" version="1">MCFILFSLLSIFISCIYGNTYEIVPDNIFSAGHLLYNSLKLDPKSASLYVAGKDSLFRLWIYNINDTSSESLYAKKVLVTEKDDKEECIKLGNSELECANWIREIFQTSNGDLIICASQAMKPNLMRLNGLSLSTIDEPTISIGVCSTHANTNTTAIYVEEGNPDGLPAIYSGIRTGLSQENHLIYRPPLIKNGKEIFSSMRSVFTDSKWLNEPQFVGAFDEGNYVYFFFREIAVEFEGCGKTIYSRVARICKNDLGGKNVMKQVWTSFIKARLNCSLSTGSFPFYFDHIESIFKVKEDNDVYFYASMRTAESPFQASAVCVYSLNQINQLFNNGILMEQPNVNSLWVQTPPENIIGKRPGSCVSDSRVLSDSDLHFAKNHLLIADSVSGGEPLIFDRDKLYSTILVDTFDKENGNVIFVHVPADQEIIKFSYRKNENGHKIVRKLVNLKISTFKKVNALSILPNEYLFIADDDKIAQFRLAQCDAYDNCASCASDPYCSWNIIREECFFTEKHYKTTVGWISGSLNVDKCNTRIKGIEKVLYPGDSYILKGKINSIWKKNGKLLENDSENLVFTKNGGLLIFNATSDQTGTYECLLDNIRISLYNIVVDNEKCTQPKSIEQFRSIQREWCKKFDSYKTNLAKWQSWYDKNAHCPRVPEELNGKMVPPLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8J2</accession>
    <name>A0A0N5C8J2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GCV_T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8J2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8J2"/>
    <dbReference type="WBParaSite" id="SPAL_0001423800.1">
        <property type="protein sequence ID" value="SPAL_0001423800.1"/>
        <property type="gene ID" value="SPAL_0001423800"/>
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    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001423800.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30851" checksum="2572E42F090A7734" modified="2015-12-09" version="1">MLRSHLLSFRKLISVKGNDSFSFLQALLTRDLRELEKNGNGVEFSLLLNAKGRIVTDLLVYKVEDEFLLEVDCNMVEKMSKLLNMYKLRRNVYITNSSKNVNFSLEKITSNPNAYLDPRIHTFGTRILCDESTNFCINKEEEKNYHLRRMIFAIPEGNSETENELPLNMNGDLMNGIDFDKGCYVGQELTARTNFLGVVRKRLLPLKFESTSISNSTDLFNENNKKVGKLIKRIDNLGIGIVSVDKIGKEVRCNDESVLVLQPEWWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Y6</accession>
    <name>A0A0N5C9Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tnp_DDE_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Y6"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001471300.1">
        <property type="protein sequence ID" value="SPAL_0001471300.1"/>
        <property type="gene ID" value="SPAL_0001471300"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001471300.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19878" checksum="3838FA83FE0BB47B" modified="2015-12-09" version="1">MPNAPKLRYYKKKQSLNEKTRRVIMSTYYENKKVQAIKNNMLLNIILGFILNIIGCLLNYLRTEIEEAMIHNTIDKKFIEYGMLGILNETAAEKLKVKEFETPSCILRVMLTTFGRMANIIGTMKIFKGFTQFLSEKRRLKLRLTTEKFIEDGEGQAEFSEFFNECCACCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA29</accession>
    <name>A0A0N5CA29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helitron_like_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA29"/>
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    <dbReference type="WBParaSite" id="SPAL_0001475500.1">
        <property type="protein sequence ID" value="SPAL_0001475500.1"/>
        <property type="gene ID" value="SPAL_0001475500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001475500.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45886" checksum="BD1C1B1358474067" modified="2015-12-09" version="1">MVKALESVQETKDFTEKRQKSKKYLKKQKLFPARDEEIIPNEHYLGTLSVSCEHCQAMFYEKETKYKQCCEFGGVKEYERLFNNFPKFIKDLFIGEDEESIYFKKHCRRINNKFAFASYTGQQRDFKTSGPLTFVLHGEAKRVINTAVPENKDNLSYGQLYFYGPDVAEDIRNKNANAFNEISVISNLTHIISKINMLALSYKHFGDYIREQELKHKNENKAVPMYKLVLRPPANKNDRVRNLPEVTEIAVIFQSEDGEVPDYNVLLCNKTGKLETLSHYSPLKDPATYPLFFPTGAFGWKEKTTYKKGNEQRSLTKLVYYQNLIAVRPSFNPLHHGGLLFQLFVVDAYTAIERDRLNYVIKLNKELKQKNNKQIEDLLEDYLIGDEDNEEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAV0</accession>
    <name>A0A0N5CAV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CAV0"/>
    <dbReference type="WBParaSite" id="SPAL_0001501800.1">
        <property type="protein sequence ID" value="SPAL_0001501800.1"/>
        <property type="gene ID" value="SPAL_0001501800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000080">
        <property type="entry name" value="Zinc finger homeobox protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000064">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000081">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="1280"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1361"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1473"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="1602"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="1282"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="1604"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="325"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="845"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1103"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1553"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="885"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1149"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1554"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001501800.1"/>
        </source>
    </evidence>
    <sequence length="1918" mass="213929" checksum="418C8C8583E065DD" modified="2015-12-09" version="1">MNLSKSSDQSNAGNHYNFHNNPNDIMQQLLAEPYSMLLNSDFSQMFSNASNNSIIMSTPSSRNSSKTLKCPKCNWHYKYQETLEIHMKEKHSDIDVDCLYCTLNSPHPKLARGESYSCGYKPYRCEICKYSTTTKGNLSIHMQSDKHLHAVQEIPINNLNMNTNNSGNHNSLNSLLCSTTPSLDNDPLSVTENNFQCLICGNFSSTSVTKMLRHVEEDRSGTTVGDINVIGGLYQCNLCPYSTNLKANFQLHTRTDKHLQRVQIVNHMRESNQQFVLGPSTLSSLNTIKSTVQVRCRCCQELFSSSSAFKEHTEGQNHQSRLNMLVNSGSSNTSTTSSRTNLVDQRSSSSSSNSSDSQMNGRKCNEILKKCKFCDFTSNNEHEQIEHISNHSHIFDLNTSTGTRNMKITTAEAPPCQSSKLEITDDCNEGNGEDSFSNDLSMKLLPKDSRLLCPECIFSTESPASYQAHISSNQHLEEDKQLLEYFLKGEKLDRVEVVVRSQYKHCCSNCQLAFKQESDLNIHKIEHLFNVQYPCNKCSEVFDSKVILEDHISNNHFYCELCDINFEEKHQLITHHQSLSHLERAKKMLEEKSSNFSLSDEVKQALSKTPPSCEEDSLSNTGNYRCNICSISYGGPSALDAHLNSLSHQLQLNRLPEMVSNGEICPDVPLYTTPESNNDSNCKSIGQTLLNEKAFASMVIEHQQQQNAFAMFNMLGGFNSIVNNNGGTVPKSSTHPIGENSPQTMTTGVDFLKMLDQFGLDTILSHLNFTYDLSILRTKIARLSKETVGDICQVRCDTCQNEFSSLLSLKMHYQQVHSTDIPTTVIENFTEKLKFNLELLEDKENSQEGQEVIGQSSTPTSPSNGNLKRKVSQSPGGEMNQNDGTAKRSKEDNCKIENNDNLSQNSSTSSSPNLEHNKNDNIEGSSVNLGNTNSLNMDINTQMNMMQMLVGMPCFNTQFFNMINNQEISSNTLLGGNNPLAPSTSSLSNSLNSFVGLSNAGACSPQKRARTRISDDQLKVLRQYFDINNSPSEAQIKDMSIKTSLPEKVIKHWFRNTLFKERQRDKDSPYNFNVPPQVSIDLDTYEKTGEAKIVSLKDDNNLTNISTNIEDDDDGTSSPTNEDKACNNNNKGVENNLKSSVSLKPKSINNLSTTDNTTTSLSSPLSTSNLPVNVPSQLPNQNSTSSSSSSNSGGGCGSNTSNTGTPLSNNILEAYANNPFVTAAMNPFALFFQNSLRNPNDLLPGLNTFNVPSGNITSPSTGNINSNINSTASMVMTSASGRRANRTRFTDHQLRTLQNFFERQAYPKDDDLEMLSKKLQLSPRVIVVWFQNARQKARKIYESHPGGDNAERFVRTPGCNFQCKRCDLVFQRYYELIQHQQKVCYKGDRQALKSDNKSVEEGLSEEDRAEIGNLDSLFNMTNSESGEIKKMSNNNIGGMIPDELLKMFSRDKRDTDGMLKLCKNKEKESLFRKRCPSCSTIFTSKEQLINHITTSHADQPHMFLLLNVDLLPDVVGEENDETTTVNNTTSLTTDPLAFLSTFPLNLASLGGVQNSNSNEGNNSEGDDNTIEYSLGNSVSPASYNRSPRDSSVQRNSPNSIVNNSKRFRTHLTPQQVHVMKCIFNEYKTPSMPECEIMGSHIGLHKRVVQVWFQNARAKERKNKNNTDDGNVNFLNSNLNRCDLCNINFNQSNTSLQDHIFTKEHIQKIKLTCDESGNSDGNNSNTEFPQLNTFLENLQPSKQNSNINSGGGIKKQVSGVNFDSMAFPINFMNTLTGTPLPNVFCDPNIFGTPIDMLQVSKSVVKQIKESINNGLSSTTFTQDGLPFSSLETVVSSQDFKLSKSLDIEVGWACPKCTNVFQSEAYLKNHQSILCQGCTDVFKLIQTHIECIPCDLKFGPQAEFKTHCESSSHIGNRGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB77</accession>
    <name>A0A0N5CB77_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2 12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB77"/>
    <dbReference type="STRING" id="174720.A0A0N5CB77"/>
    <dbReference type="WBParaSite" id="SPAL_0000923200.1">
        <property type="protein sequence ID" value="SPAL_0000923200.1"/>
        <property type="gene ID" value="SPAL_0000923200"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001514000.2">
        <property type="protein sequence ID" value="SPAL_0001514000.2"/>
        <property type="gene ID" value="SPAL_0001514000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12083">
        <property type="entry name" value="DD_cGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0140">cGMP</keyword>
    <keyword evidence="9 12" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="200"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="318"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="473"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="734"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="479"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000923200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001514000.2"/>
        </source>
    </evidence>
    <sequence length="784" mass="88678" checksum="CD30D20EA084A1B3" modified="2015-12-09" version="1">MSQSASATARQAGSGHHGTSIRSFFSKLRKPSGSLSSSNFQVQVGNRVYDASELQKLIPQMEDAIDKKDRLIRQYQQSLEQRDQEIKELERQKKYFQGECDKLRSVLEQTTANAATPLSKNNSTSGSGESQKCTIETVNENQKTKDPKPEKEGHSSRAKKVAVSAEPANIDQNRTVTLQHHAKSAGAKQLIRDAVQKNDFLRQLEKEQVIECVECMYEMRVKAGEWVIREGDPGDRVFVIGEGQLEVSRENQVLSTIGPGIVMGELAILYNCTRTASVRALSDVLLWVLDRHVFQMITMRMGMERHNQLMNFLKKISIFENLNEDRISKVADVMDQEYYAGGHVIIREGEKGDTFFIINSGQVRVTQYIDGDHTPREIRVLKQGDFFGEKALLGEELRTATVTAMVPGVEVLTLDRESFLKLIGDLEELKRDYGDSNRRIVVNSSTILPVIEATSPEKAAIDKELVNVQLRNLKRIATLGVGGFGRVELVCVNGDKTKTFALKALKKKHIVDTRQQEHIFSERNIMLELRTDWIISLYKTFRDTKYVYMLLEACLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKSIVYRDLKPENCLLTNTGYLKLVDFGFAKKVPSGKKTWTFCGTPEYVSPEIILNKGHDQAADYWAIGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPAERLGSGSGGVNDIRKNRWFMGFDWDGLRSRTLKAPIYPKVTHPADVSNFDNYPPDQDVPPDEFSGWDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB85</accession>
    <name>A0A0N5CB85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein roadkill</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB85"/>
    <dbReference type="STRING" id="174720.A0A0N5CB85"/>
    <dbReference type="WBParaSite" id="SPAL_0001514800.1">
        <property type="protein sequence ID" value="SPAL_0001514800.1"/>
        <property type="gene ID" value="SPAL_0001514800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03774">
        <property type="entry name" value="MATH_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000003">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001514800.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46197" checksum="0B9684507A63CD90" modified="2015-12-09" version="1">MDVDGGGQDDVVSDGPGQQFQSHNQANGIRPGSPSSSGGNGGGSIAAENWCNTQVKVIKFNYMWTIDNFSFCREEMGEVLKSSSFSAGTNDKLEWCLRINPKGLDEESKDYLSLYLLLVQCSKSEVRAKFKFSILNEKREETKAMESQRAYRFVKGKDWGFKKFIRRDFLLEESNGLLPDDKLTIFCEISVVCETVNINGFSTATKVKIPSPKLTEDVGNMLESSQFSDCIIRVDDIDINAHKVILASRSPVFQAMFNHEVRESQSNIVEIKDFHIDVVREMLKYIYTDSSPNLEKMAGEVLAIAEKYNLDRLKIMAEQSLCNNLSAENVCEYFVIGEMYSADALKTNCLEFINMNATDVMNSENWNDFVINHPLLLERLYRNLVQLHRPPIINGSGNRKRPKMSYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBE7</accession>
    <name>A0A0N5CBE7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBE7"/>
    <dbReference type="STRING" id="174720.A0A0N5CBE7"/>
    <dbReference type="WBParaSite" id="SPAL_0001521200.1">
        <property type="protein sequence ID" value="SPAL_0001521200.1"/>
        <property type="gene ID" value="SPAL_0001521200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895646" evidence="1">
        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001521200.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="65933" checksum="41167593CD1C307B" modified="2015-12-09" version="1">MNAIVTIVFLIFIQSIVCEDDKLKIKPIDMRFYDEVNCGRSDYLNDFESSFKQSDSSYGFRSMVNSGIPWMARIVDHNKTTICNGILVTQLHVLTNFGCLKGIEELIKQQTEYNILYGHYQVRIGEQSSRDVCDSDSDGILNCSSKVLLRYINVLHLPHPVLDDDLKYGVIELNRPVTAIPHACIFQYQMDFLGLEEKEEVENVVSLMWGMDNDDNLDNFELSAYFYKETFDYKNKRFANSFGCKIREDYLMVVEQMQTLMWKSKLKGAPLLRKVKDNQFGVYGIGEDTCVKNFNKEIKHVQELFFVTFKSAQYFLFHSLNEVNHDEENVGNEFHDISKFYDKDTCGKIQKENIPYNTDSFTNEVSYPWILTIVKGGRACMGTLISKMHVITSYECIYSTLEVEPKRKFEVHLKGVLVIQSKKYCTYWRRKGSIIIFGKESPHSCYNYDIQYREVYQIFSTNSRNYKELSVILVLKEPFNDIPHVCIDEKLDPLNDNEILKKYLVYYNTALLDDLKEIVFLAKYPLTKVSESQLSLNDHEISVTDDNYKYICGKSTGSSIFLETHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBJ7</accession>
    <name>A0A0N5CBJ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001526300.1">
        <property type="protein sequence ID" value="SPAL_0001526300.1"/>
        <property type="gene ID" value="SPAL_0001526300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001526300.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36897" checksum="097156D178AD92F0" modified="2015-12-09" version="1">MSEILYTDGYKNTSNSIGNAINYIFVGWSYIIISFIAIVLQILTFIAFFDSRIYYKSVAFKIIFSIGFTSIFQQIAHFISGFYIIYRCDNDNLFGNIVGSLLQSSYMTSIALNTLLSINRFDVLYSGEVLPTFNRKLFYKICYVIIYFYFMANVIFCNIKKFRLIFNINEYTWMFVKSDEGRSWGNVIESYCNYTLLTVSSILFAASIRKIIYLRSLTSIGNKVKYYDIKVFLHAIFNYLFVLVLEICWGNWGNLFYLHVLFVIMINYLYIFVCCSNTIFGVILIIEIRKGIKKLLTRHNKIQRTIIAFNQVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBZ8</accession>
    <name>A0A0N5CBZ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBZ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001540700.1">
        <property type="protein sequence ID" value="SPAL_0001540700.1"/>
        <property type="gene ID" value="SPAL_0001540700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001540700.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8506" checksum="60FE61B2481D1753" modified="2015-12-09" version="1">MSGCFVSVKFIFLVLVATFIFNDLQVEGRNFRMYHPKIIFRFNDAVKAYNDGTKIVYHQPYETFNFQRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD49</accession>
    <name>A0A0N5CD49_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Two pore potassium channel protein sup-9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD49"/>
    <dbReference type="STRING" id="174720.A0A0N5CD49"/>
    <dbReference type="WBParaSite" id="SPAL_0001579500.1">
        <property type="protein sequence ID" value="SPAL_0001579500.1"/>
        <property type="gene ID" value="SPAL_0001579500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005408">
        <property type="entry name" value="2pore_dom_K_chnl_TWIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF249">
        <property type="entry name" value="TWO PORE POTASSIUM CHANNEL PROTEIN SUP-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01586">
        <property type="entry name" value="TWIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 13 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 13" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="106"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="198"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038061-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001579500.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38664" checksum="4B15D381A5946C2D" modified="2015-12-09" version="1">MGLEFFVNHNNDVNEINASNSHIEETNTRLGFGFLVIFIYLLIGAIVFVKIEGPVERIQYEAYKEFRMAWEDKLTNLGMKLEDIDNLFSNIKDAALSGVWIEKNQTSESSWTFGQTFFFCGALISTVGYGRISPKTHYGKLFTIIYCIIGIPLTLSFISALVLRLRQPSNYLKNKLSSKLSHVFHNFQIQYIHLAVISIIVLISAFIIPSYTFSQIETDWSFLDAFYYCFVSLTTIGLGDYIPGDSPNQSFRELYKLLVTVYLLFGLSVMMLFLATLYDIPQLNLTKFFITKNSEYVDLNKDDNITNVYNKYKEEDDETGGIPINQYPYSIQNTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE05</accession>
    <name>A0A0N5CE05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE05"/>
    <dbReference type="STRING" id="174720.A0A0N5CE05"/>
    <dbReference type="WBParaSite" id="SPAL_0001609500.1">
        <property type="protein sequence ID" value="SPAL_0001609500.1"/>
        <property type="gene ID" value="SPAL_0001609500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001609500.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="92351" checksum="56005693FA3E3B06" modified="2015-12-09" version="1">MPKTGEVVYLQNNTINDTSFVYNKNAISDGDKNLTHSSRSSIENNSPEVNENFNKGIERNSSSSMDMLSEEDAYDEIFEDDLLPLDQLAPYLAHLESQHYYRVEETDDLIIMEDQGDVIYEEVVLLRSTLNQLLGLTLCYQHNDRLNQDAIFINEIEKNSVAGNCKKIQVGDQIIQINGINVRSRSQAMAEFSKQNLQVTMLLARSFNMELNNINNTNNLSGQTGDETIKALPKNIFSKNRFLSRNQGNLSPLPEQSISLECDVEDEILTDQNSNNSALEKDSGLSRGTDSDPDIYTVPYDNLDNANIFSKISPPSITSIPQQNRFGMTNNEISSANTTKFEKNLEKELENLHLEMELIKKDCDNLISMSTIFSLPKALTKRSINKSIIPGMVKSPILQRPLPTPGGIINKTHLIGNSSLPNSPILSVRNGGKKYPHFANIIEETSSAYNTGNDSCRSTPNKNDQINFIDSTLHQLNSLNKHQLLAGDSATTMGPYLTSVIGTSPKTGHLKSLSITNNHSLDSQRNNKPQKEVHFNDPPTIIINNEKNEKEEGTYHTVKNHSKFRLPKYTIKNQVFISKPIRVGTMKKVKEGIEYRPGETTYARPEDLAETIKLQQQALRKAIANKEVIHCSNSLPSSPIIPNHSKVSDRVIKHITQKQSNSLSLAQKVKSSQTADPVNYEWKVKRRSDGSRYIIRRPLRTHQIRAQREEQLNKERTGISTDDDAGSEMKLGKFWTREERKKHLEKAKAHKQRQLQKLIDQEKNIPDQTIVNLSNKKMMKKKGQQVFDKFVTIQEFLTHGSRDPNCPVIEGVLSVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF97</accession>
    <name>A0A0N5CF97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abdominal-A</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF97"/>
    <dbReference type="STRING" id="174720.A0A0N5CF97"/>
    <dbReference type="WBParaSite" id="SPAL_0001653600.1">
        <property type="protein sequence ID" value="SPAL_0001653600.1"/>
        <property type="gene ID" value="SPAL_0001653600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001653600.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7061" checksum="E1D7CDFCBEB4E4A8" modified="2015-12-09" version="1">AHFDASAYNQAAASAAVSSSLPSAVYQGNYHGTGVPNASAASNFLNGSSFATFHSVNPFAATLHTSTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFJ5</accession>
    <name>A0A0N5CFJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFJ5"/>
    <dbReference type="STRING" id="174720.A0A0N5CFJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001663200.1">
        <property type="protein sequence ID" value="SPAL_0001663200.1"/>
        <property type="gene ID" value="SPAL_0001663200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001663200.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="42053" checksum="F9AD32A2FADE3994" modified="2015-12-09" version="1">MKNTTPEDQIKRSRMESMNKNGEVISDGKKKPILSYAEVAKKRENSKHRDSKEDSQEMRKSIKEMNPKERYDYFSKDRGKIFRFDVKPWMPTFEIDLLIEKKLRPLTQVWSKTKITDIESKKTWRQASKIMIIATKVLKSYDTRKVDYDGTSVEDNRKKGKVKTIEQVRFFTKSKISTLKKRVAYLNEKKRRDRIRMRFRSKPSLKSLVDTTPLDIEIDKSEIEKYLIDLFSKKDCEVPEPESLLNKWVEYSKNTTSIDEDSKPNFNEEIFNECLKWSRSWKAPGTNKLYMKIFKVLNSCKIFLMEWIKAVYERRCNLTDEDTRGRAFGIFKKGNIDDPKNYRFINVTNSHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFT3</accession>
    <name>A0A0N5CFT3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFT3"/>
    <dbReference type="STRING" id="174720.A0A0N5CFT3"/>
    <dbReference type="WBParaSite" id="SPAL_0001671600.1">
        <property type="protein sequence ID" value="SPAL_0001671600.1"/>
        <property type="gene ID" value="SPAL_0001671600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF4">
        <property type="entry name" value="PROTEIN LET-99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="79"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001671600.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="85258" checksum="1A53778D7180261E" modified="2015-12-09" version="1">MVTLVKKLRNSVLMSSFNSEGHTPKKRFSINEIGGRRKIEDRYSTFETREQWISQKDIDGLKSGKFRQTRSFVIIGRLFKYGIPRTVHTRMLKSYKDSFTGREAVLFLMTNIVPRVYDPKPGTDYRNISISLLSYFLREGFIIEVGKGYSDDSFKDSTSKLYCINENYTFPEIPFDFNPTESSRFDQSAFSTKRGVFYGNTRQRMISLSQDSGFESTMPTGSPELSPNTTNVIENLIPEYISCNTIERCSLVNIPTEIELSPSNNDDDEKVSNYSKNDFSSTSNTITYPSTSYSNLVVINSDSKVFETVHSNRSRTSVILYTDQDNFEIFYDSDTASDSGEREIFAECGQNGHSLTHEMIYGVALRGFLREIVGSEVRRKLLKQLNYSCSDLRRNLENVDLHQIVSVEPDMDVIPRIISSMESMAVSNDSKKVVVDLSEYDNILHMTEADQLDHFEGKPYLPEDFTRLILKMAFFYKSDNKRIRMLLKTCRQNGRTILKEFKPLSSEFIASIPEDFDWTNEENSFLFERDTSKILGNGFLTNDIEEEDAGEFLDLISSLLLLLPSYIRRRIQLFVKYMVTLEKSNTIQLKAQVPNRYFLLRDFSNILVDSSSKTVCVWITTFFLDNYSRIFTFPPKIQATVSALHKTSPPRPTRKSHEDGKLCTDHECYRCFQYVNKQLRTQLTYIITNPNLTSTVRKKELETFKSRYPYIYYEVFPKNTTKLSKRLYSAVKSIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGE8</accession>
    <name>A0A0N5CGE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Str_synth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGE8"/>
    <dbReference type="STRING" id="174720.A0A0N5CGE8"/>
    <dbReference type="WBParaSite" id="SPAL_0001692500.1">
        <property type="protein sequence ID" value="SPAL_0001692500.1"/>
        <property type="gene ID" value="SPAL_0001692500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="165"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001692500.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44513" checksum="24E8E5B1FCEA407C" modified="2015-12-09" version="1">MICKIFIFLLTIVSSIFFYQFFIDDHGLKVSDYKYQDPPALTGVLEENNLLCGGDWLLKGEILGPESIVIDGDYLYTGTHDGKVVKIRNGVIEDEIKVNPLAKNCDGRNISVCGRPLGIRKLNKDELITVDPTKGVYVINFNDKTAKLVFDVNTKVKNKKPMFLDDLTIYNEEEIFVTDASTKHDYNNILKIIFEHQPRGRVLKINIKTGEASEVATGYYFPNGIQMHPDGDSFVVCDFNTVKIWRYYVNGPKKDKAELFIDNLPGNPDNIRLSKSGKSFYVALAMKRSIEKPSIFDKLNNGYFARSIRNFLASTLTDWLIIKIENIVTHPGTLFLELDLDGNIIKSYHDNKGRTLPGVTEVAEDDKYFYMGSFYVDYLVRIPKRQSPIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CID7</accession>
    <name>A0A0N5CID7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dystrobrevin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dystrophin family. Dystrobrevin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CID7"/>
    <dbReference type="STRING" id="174720.A0A0N5CID7"/>
    <dbReference type="WBParaSite" id="SPAL_0001759000.1">
        <property type="protein sequence ID" value="SPAL_0001759000.1"/>
        <property type="gene ID" value="SPAL_0001759000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16244">
        <property type="entry name" value="EFh_DTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017432">
        <property type="entry name" value="Distrobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038204">
        <property type="entry name" value="Distrobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="426"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001759000.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65785" checksum="373D11815AE95FD4" modified="2015-12-09" version="1">MWNGSMVSMEGDSNQSNIIPQTEGYMNELQGLIEEMRQQDFDSIRFATYRTACKLRFIQKKANVHLVDIWNMIESFRENALNAVPSNSTLKFSRLELLLTSVFHNLNKRLPTTQHIDTDKSISTLLSFLLGAYDRQHNFRLTIFSIKIALSVLSAGKLVDKLRYIFSQISDSQGIMEWDKFVQFLQQILALPKAVFEAPTFGYNDNCPEQCFQKDAKTNLNAFLDVILSESCPPCLMWLPLLHRMASVEHVYHPVVCDSCQIRSFTGFRYKCQRCSNYQLCQNCFWRGRTSQNHSNEHEMKEYSNYKSPTKQLAHSIHKSLQCIPLTGKSKNLELDSKLQRPLDLSNIIPVMPNFNKHQVHDITSDWSNNLPPGTIGNSGNLDDEHKLIARYAAKLSGRQSYRDKKSNNNLLRYDGVDSYNEKMIIAQLEEENSEMLRELAAIERQNNLIDSNGQLSGLKEKKFELENKMRCMQNTRKELMHQLEQLMKQLNTSEPGRGYKSMSQMPESLTGVNSRITNAFREHSLPTSNRRSMSQIPASQLQGDLLQAADAITENVSEFIHELDMANDEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIH8</accession>
    <name>A0A0N5CIH8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIH8"/>
    <dbReference type="WBParaSite" id="SPAL_0001763400.1">
        <property type="protein sequence ID" value="SPAL_0001763400.1"/>
        <property type="gene ID" value="SPAL_0001763400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001763400.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34126" checksum="0A1CD4E43F668D34" modified="2015-12-09" version="1">NYTSTSEDSALEKEVTQATDISEAPREDALMSSIRNVLSASNSETVESCASIANNTDTAPKNSLFQTLKSTLGDNIDMKVYQQAILEIKEILNSSFITVEQFQKIKSKIGCFDDPNFLAPVFQPDVYSYISKDRFTSADGYLFRASDLLLQLTAFLSTYVGTSSETSESLFTVSSLKSAVDLISQARMILAVRAINPKLKCPLIHHSPSVTTIHSDGLKRFILLDNEDQSKLLASQRGNATLNQLANKRPYSRISQESISSLYGSPSIQPPNVPTPQESQQVNGLVTPVDKILQRNVDILSYKDGVKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIP9</accession>
    <name>A0A0N5CIP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA_synt_1c_R1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIP9"/>
    <dbReference type="STRING" id="174720.A0A0N5CIP9"/>
    <dbReference type="WBParaSite" id="SPAL_0001770400.1">
        <property type="protein sequence ID" value="SPAL_0001770400.1"/>
        <property type="gene ID" value="SPAL_0001770400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001770400.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21634" checksum="1BA6DC14072873AB" modified="2015-12-09" version="1">MLDSDYKDKFTNKYFAILQKRNVRFGILGLNSYYKTKLENGNPISMGEFFELLSKCEVEPDVETFEILGDYFVKRVESLVMSNQIEKARSVISSFENERKEKLIYTLATHLQPRAKTSQEYLMNSIFEKTIINDAQLNAALEYAHSRLKEIFNEEEFSMEFEVQVQNLEQSTFSAEIIGEFVANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W6</accession>
    <name>A0A0N5B2W6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel subfamily K member 18</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2W6"/>
    <dbReference type="STRING" id="174720.A0A0N5B2W6"/>
    <dbReference type="WBParaSite" id="SPAL_0000041800.1">
        <property type="protein sequence ID" value="SPAL_0000041800.1"/>
        <property type="gene ID" value="SPAL_0000041800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF317">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000041800.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="84876" checksum="7D7994579F68B10B" modified="2015-12-09" version="1">MICGVAVYAIFGAIIMQNLEAKPMVEEQNSNKRGTRELAKNEDNEILKINRHCLVEELQKSINTMCSESKITLGDMLHSIDSCYHVMVNSKSVDSLHIIEKIIHNTETGKDEVVLFEEWSFSDSILFAFTVITTIGYGNVAPKTFGGRMFCIFYGLIGIPFTLLAIADLGKFISEVMVSASNVYNVTVKKVRKKLRRYKNYRYLKIFTRQKKSKNPLDSNKNSIYINPEHVEDLEGALNYKEDVNEPLTLPSSTKKLNKSYNSKESIVNYDDNASIVEYEDGERKENDNSESEDDENDNAYSNQTCSLIGLFIIYIIIGAMMLSSYEPEMTFFNAIYFNFVSLTSIGLGDIVPKSQEYMVFTIIYIAIGLALTTIAIDIAADYLKKLHYFGRKIENVASVTIWFGGNKLTMRQLVKNLGDQFNLPITTIRNLNLDDFVDKAIKVEAGEIETLRPPPLQPENIKTLDESVVFADGSNDWIPNDEDDFNDVYVEVEQPIILELSPKHATPVDNNITLPSPEEVIHIKTPTPEPKSPTPPYIPTPEERIPTPPKVETPEPEIPPLKTPSPVMKKEPLVDEYMLNQKRRGYSEDAWRRYQEYQKQWQKLRQVKRSTGKSPNRNFSSVVEVATNELIKNRKTSDTSHLSSTNNNSPSSTINNVKKRSLQSEVFRPSSRNHLSSSSTTKANEGARKRSPSTNESRKVDSKKSVGFTNSSIKNDKDTSLEGIKTGTSSTPVKGKPPSITSLSTRLPKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2Z1</accession>
    <name>A0A0N5B2Z1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0000044200.1">
        <property type="protein sequence ID" value="SPAL_0000044200.1"/>
        <property type="gene ID" value="SPAL_0000044200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000044200.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47182" checksum="9EB33AF8D4F30AD8" modified="2015-12-09" version="1">ICQSVFDNDELTEVIRNENYDIMISEYLTVCPGFLAKHWNIKKNIYTSAMTNNELLYDYYGLYFPSSYVPTMFHHANDVMTFRQRIANFFDYHISRTFFKYITLPKFQNIYSSKNNGTYVSMEELTRNVGAFWLNTLPFIDFPSPITSKIHYIGGAGIPETKPLDSKWNDVLSKRKYNVLLSFGSIAKSYQMLDEYKVGILNTISDLSNITFIWKYEKDISTLPIKVPSNVILADWIPQNDLLNDERLNLFITHGGMNSIVEAGARSTPIICVPLFGDQKRNAGMVQRLGFSEYYNKENLKDSEMLKETILKVLNNKRYKEKAERLGKLMREVPFKATEIIVKTTEFICNNDNIPEMNLHGSNMGVIEFFNLDIIFILIVLFTTISVFIYHLLKKIFTFKIKYKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B359</accession>
    <name>A0A0N5B359_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B359"/>
    <dbReference type="STRING" id="174720.A0A0N5B359"/>
    <dbReference type="WBParaSite" id="SPAL_0000051000.1">
        <property type="protein sequence ID" value="SPAL_0000051000.1"/>
        <property type="gene ID" value="SPAL_0000051000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000051000.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="36336" checksum="ED2B7BC2C1286660" modified="2015-12-09" version="1">MSFFKSEPEKCKVFLSIIDIVIADSIRTNFVVLDGTFINLAEVFNMKDQEIVDREHVFLKHSLRAIKFLHKNGFIHGNLSITSFWLKFNPKKEAISIHHYKYIEEILLADLEYCIKIKDNADNSEIKKISEQRMLSKPKSYKYCALGLHKGEKMCMKFDFESIYYILVELYEKKLPWDKFCDDETLIRREKERMRSPTYDFFRNIPEHLAEIICFIDKKSPDKVPDTEDIKKRFYHYLKKKSFYDEDNYILGDSDYTRAAEHYRLIRKRREESKEPFSNSIYEEIIGEDKKQKKVLPIKQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3B0</accession>
    <name>A0A0N5B3B0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3B0"/>
    <dbReference type="STRING" id="174720.A0A0N5B3B0"/>
    <dbReference type="WBParaSite" id="SPAL_0000056200.1">
        <property type="protein sequence ID" value="SPAL_0000056200.1"/>
        <property type="gene ID" value="SPAL_0000056200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01218">
        <property type="entry name" value="PH_Phafin2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037871">
        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000056200.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34309" checksum="A706CCAD12E94762" modified="2015-12-09" version="1">MSYSQQRSNLEANDRRIAGIEALFGNTGIRLKKEGRYLIGEGVLMKMCRKKPKQRQFYLFNDILIYASFGIDKKHFNKQHIIPLEKVQLIDLKDEDNKKNGFVIRTPNKSFAVYAATNSEKNEWINHICKCIAYLQRECGKKLATDFAAEWIPDKEAIVCMVCSKTVFGIIHRRHHCRACGKVVCGRCSNNTWFLPNISSKEVRVCDECIVLLREGKKIIPYAHGKTDKSNNDYLRNSHNIPIQSLNETTLSDSSDDDEDESSNNKNVNKTLRNYVYKNPQDPFDDYPSSDISHTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4K5</accession>
    <name>A0A0N5B4K5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4K5"/>
    <dbReference type="WBParaSite" id="SPAL_0000100700.1">
        <property type="protein sequence ID" value="SPAL_0000100700.1"/>
        <property type="gene ID" value="SPAL_0000100700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="599"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1435"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000100700.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="167546" checksum="8A32A1969297305C" modified="2015-12-09" version="1">XAFSGLSNGPRSSNRGHNGFLFGNPSKRRGSTGSNRESLLGNRQKSSNKNRKRQRNNNPRRKAPFPVHEPFRRIWQQTLIAELKRLYPSTATTNTSPTKTPPTAKLRPRSTFDSVREVQSNNSQVSTSNIPTPTTYVSETSLNIQNMSENTTSIQPTIHGTTVMNTQSWTTIKEYNPAEDNIKSYLQRLNLFFDMDNITEDRRKSIATLTKMPASLLNEIEQLPQTESQELKNNFANLRDYLHKVYGADKAQKNAQLRLRTFRIREQPKFIAEDLRQYEQLLRTTHTGSPDELLNRFKSHLLDKIRNDNLFNKLLNTTYESITELILDLEATMLVYQNRSQQLNRPQKTFQDRSNFKPTRNTKLICTWCQKPNHKEDVCRYKASGKPKIESRCTPNFTQSNKTDKVDTLMTEAKSPNRGLIGKAYKIQVTLNDQPILARIDLGARTTIISQDTADKYHIKYDSNKENLTLKVLNDGIIENVVVAKNTMLEDELLLGTNIIDKFNQFTVNKDFITIDGMDVYLTDTLHKSDHNTNLQHKIDQLLNKYKHISSSSELDIGECPIPIPNKKLNGKTFRKPPRFTYNPKQEELLKEYCLEMLEAGILIRQDTSYISNFVLVPPRSPEGTTRFAVDLRRLNEITVPDPYPTKSSNELFNYLSTAAHYTSLDIAKSYWTLKIPKEDIKYYGVYSPLGVLCFTRLPFGDINAMAYWQRIYNQIIREVLPHNAISYVDDLVIYTSAEQSEDQHLSLVEKMLQQFERYNLKFNSNKSQICKPTIKFLGWKVSSQGKIPDPSNVNSILNRKVPDSIKNVKSFLGATGYFRQSIEGYAQLALPLTNLTKLKSTFQWTPDCQRSYDTIIHKLSTAPVLMLPQFDRAFHIYCDSSMEAMAGLIAQYDNNKRLRPIRFYSKKWPYFKRQKSINLLELQAVCYTLLGNSDILALSDIIVYTDNKSIISIFNDSTDPQFTRYISYISSFKVVFKHIRSCQNNVADDMTRCEILEQEIQDIDILNVDPILIETESKVEQSDYLKKRNETFINAQKKDPYIQSLISKFPNIDTNKFIILNNILYKKVERKNTELSKDVLLPILPKNMVHEYLTSIHDFLGHFGIQKTILFAKDSFYWEGMEDDITKFISSCEACQLQKAVRDQHPAFERILVPQEPFSIVCLDIMGPLKDGQNKIYVVNTIDTTTRYWIPYLIEDQCCDTIIAGLISNVITKFGAMKYLLMDNQSSLKTPQFQQLLNKMNIQCIYTTPYHKTGNSLVERSFRTMENIVSTLIAAEKKHDKKVNINFAEIIPQTALYYNVFPNMTTKMSPYELLFGRKPHLACSPPTPPVAQIDINPNIATSYYLLQEGWKLASEISMKVREQANKKLENADKSTTTYQPGDKVIIYRPNAASKISTNFTGPYTVKYQEGKIVYLTKSTRGRPKMVHVHDIKPFMGREGSSKTSEKVSSDVPITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4V5</accession>
    <name>A0A0N5B4V5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4V5"/>
    <dbReference type="STRING" id="174720.A0A0N5B4V5"/>
    <dbReference type="WBParaSite" id="SPAL_0000110500.1">
        <property type="protein sequence ID" value="SPAL_0000110500.1"/>
        <property type="gene ID" value="SPAL_0000110500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000110500.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="31835" checksum="FD423A78434269AF" modified="2015-12-09" version="1">MESESRIKAYRFVAYAAVTFSFVAVLSVCVTLPMVYNFVSHVKKQMNTEMTFCKGSAKDIWSEVNQLRTFVIDPKNRTARSAAYDAGVGGGGYDAGKGGHSSGPAATAVSAASSSSAVDTSVCDGCCLPGPPGPAGPPGKAGKPGKPGAPGISGNPGLPPVQPCEPATPPPCHPCPPGPPGPPGPPGFPGEPGTPGLPGKPGEDGTPGENGPRGPPGPHGEVGQPGPSGPPGDPAANEPPVIGEPGPAGEPGNPGPQGPTGPPGSDGPDGPAGPKGPTGPEGDMGPPGPQGPPGEAGEVGVPGEKGICPKYCAIDGGIFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5U3</accession>
    <name>A0A0N5B5U3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5U3"/>
    <dbReference type="WBParaSite" id="SPAL_0000143700.1">
        <property type="protein sequence ID" value="SPAL_0000143700.1"/>
        <property type="gene ID" value="SPAL_0000143700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF94">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893932" evidence="2">
        <location>
            <begin position="26"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000143700.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38573" checksum="A8799CB8FB54A295" modified="2015-12-09" version="1">MSTSFKKNYLFFIYLLVVISSFISGNDECPDEMRPLGKCINDLCPYESECILSQCCAYKTSNITTLLPNNTTNLPSTENEIDYCVDGTEAIGACLGQYCPPGYICLENVCCVDNTDSYEVEDELVNENVTQGYEIINYTENYSSEKLITESTLPVTTEIDNLIVTTEEMLTTTPEAVNNVIEKTIISKNVDIKINTTNHCPIGESIGECISGECPQNYECINGMCCKLSENINCKDVFTDCKKHLCEKEEYFEFLTLKCGRTCQRCHQQKFVKVKKVVSTKSSGKSKEKSKNTSVKKTKTRNLKCQDSRNDCEEWMREGFCYSPVYTLEQKKAICGVSCQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Y7</accession>
    <name>A0A0N5B5Y7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0000147700.1">
        <property type="protein sequence ID" value="SPAL_0000147700.1"/>
        <property type="gene ID" value="SPAL_0000147700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000147700.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35749" checksum="7BBA522E0BA47F4C" modified="2015-12-09" version="1">MQHATMIKNIVQKQVLLKECEKKCVKSTKKYSTKCANITLPFIRFFYDKNKKNSDFNFNGSTSLWKENVYNMEVDVSCNKKAGCIAKKVLMFLGLIPTVRRKDRDIYITVNYRNIYRKYQMYYDKLYDVPLNTNYDYSSIAHFADNYGGSSSEPTFDLKRLSDSGIKLTGQEIRPTFLDLEWLYTAYCKNKFAPTVKCEKGFPKSDGSETCVCPTGFTGKTCKDLQYQNKISCPGTVIHVGDKSGKKELNFNEKKNCTVQLIAPSEKRIRINVDTMECVNNNPCFEDDCLQIKYRPSMTNTDLCLCGTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6D8</accession>
    <name>A0A0N5B6D8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF862 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6D8"/>
    <dbReference type="STRING" id="174720.A0A0N5B6D8"/>
    <dbReference type="WBParaSite" id="SPAL_0000162800.1">
        <property type="protein sequence ID" value="SPAL_0000162800.1"/>
        <property type="gene ID" value="SPAL_0000162800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000162800.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30768" checksum="A01AB2119567BB85" modified="2015-12-09" version="1">MVRAPVRLNVYDMYWINEYASTLGVGVFHSGIEIYGVEYAYGGHPFDFSGVFENTPQEAEELGENFKFRESIIIGETDFSASDIKHIVKQLGQDFKGNAYHLICKNCNHFSAEFAKILTGVEIPGWINRLASISQSIPFLEKMIPQEWLTPVALQESIDNKQSLGESVPGSVITKQIPTKTASLNYPINVDYAKEATEEGEYSSNGKGINRQNGSSVWKLFQRRDSSYSSEDTSSGRTNSPGPSLQKFWNSLKNIANEEFSLGQNQPTSLPASTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B764</accession>
    <name>A0A0N5B764_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3 8">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B764"/>
    <dbReference type="STRING" id="174720.A0A0N5B764"/>
    <dbReference type="WBParaSite" id="SPAL_0000189200.1">
        <property type="protein sequence ID" value="SPAL_0000189200.1"/>
        <property type="gene ID" value="SPAL_0000189200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF64">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="10">
        <location>
            <begin position="190"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000189200.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32144" checksum="4D1D695CBF51572B" modified="2015-12-09" version="1">MYEKVSSNSGSNKSIADYQYHGNVAFIGGGNMAKAMIHALIKKDFMPKSNIYISVRSPETCLAWQEDGFENAFTSNEEMFGISNTTFQVVFICVKPQMYNSLLGELKKSYFSNVNGVVSVMAGITLEQLYEDFVSLNYHKSIIRLMPNISCQISKGVSLLTCDNVNTDPAIKDATKCMAKCMGECHEVHESIFDAAGTLNGCSPAFIFVVIEALADGGVRNGLPRHLALKLAAQTVAGAAEMVNQTEIHPSVLKDKVCSPNGTTIAGIAELEKKGVRSAFIEAITASTERAKAMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7B5</accession>
    <name>A0A0N5B7B5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7B5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7B5"/>
    <dbReference type="WBParaSite" id="SPAL_0000194100.1">
        <property type="protein sequence ID" value="SPAL_0000194100.1"/>
        <property type="gene ID" value="SPAL_0000194100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="109"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="431"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000194100.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75084" checksum="47EAC7702EEF59BE" modified="2015-12-09" version="1">MGILSTLRRPIKFSTITYRSINTQKTLQLNILQAQRWFTKPFHVNSLRSTFKLFGLSLSCGIALYRETNCYSKNFIKKEVESKRNSISEYNATFHDLWIILKPVLHYLLGAIICVIGAAYVDINIPLILGKLINGVTEILKSQDVGNFDKLHPLGIKLLGYYLFQSLLTFGYIFFISVMGEKMATNLRVQLFNHLIYHDMTFFDKQRIGEICDRLNYDVQEFKSSFKTVVSKGLKSLTQAGGSAISLYFISPKMTLCTIIIIPIVVLIGKACSAFLKELSKRAQAQNGKVSSVATEALGNIRTVKAFAMEDITIKNYKNELEKNQSLNIKLGGGIGIFQGATNLFLNGVVLGVLWGGSQLVIKKEMLAGELMSFLITAQSIQKSISQISVVSGGAVRGWSALSRIFEYLNIKHSLVPGDRTIPHHSLYGSIKFDNVTFSYETRKNHVVLDGIDLEIPYGKVTALCGNSGGGKSTIASLIERFYDPIDGKITLDGYDLRDLNPHWLRKLIIGYISQEPILFHGTIEENIRYGKPNATDDEILRAAELANADKFISSFPDKYKTMIGERGVTLSGGQKQRIAIARAILKNPPILILDEATSALDSESERLVSEALKNVTKNRTVLIIAHRISTIKNSDNIIVIKDKKVVEQGTHQQLMRKKGNYYKFVQAQDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8U1</accession>
    <name>A0A0N5B8U1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8U1"/>
    <dbReference type="WBParaSite" id="SPAL_0000246400.1">
        <property type="protein sequence ID" value="SPAL_0000246400.1"/>
        <property type="gene ID" value="SPAL_0000246400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="1">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000246400.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19082" checksum="55E4FB6D362E1CAD" modified="2015-12-09" version="1">MSSVKITTNNELDDNYRIKKSIIRYKRSKWVLPIKYHISQKLNVSVIKQAIKVVEEETCVTFNESNKHIRIKRGINFKKHHSSCHSYVGMRRIKKKYLYCFQKMALEIKHKNDTSVTGLNICGNTKTPIIVTSEGTSVLVLWYGKKDDHSFNLTYQEIDDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8X3</accession>
    <name>A0A0N5B8X3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VHL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8X3"/>
    <dbReference type="WBParaSite" id="SPAL_0000249500.1">
        <property type="protein sequence ID" value="SPAL_0000249500.1"/>
        <property type="gene ID" value="SPAL_0000249500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01847">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="von Hippel-Lindau disease tumour suppressor beta" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000249500.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20660" checksum="5BD08EA09B16E6B9" modified="2015-12-09" version="1">MDGIEIYDSILACGHKSPNSIDPVRIVFRNTLRKHICIYWIDHNGKFTFYGLLPSRKNLTIDSYTGHLWCVRCFETGNLIKLKLTHENGSSYLKEVPSIDELHNYQRNFAVFYPVEEVKSLRDILLTYFSKLPQESSIESLPLPDGITENIIRCSQFTKNFHSQTRREVSMAMMERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B911</accession>
    <name>A0A0N5B911_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B911"/>
    <dbReference type="WBParaSite" id="SPAL_0000253300.1">
        <property type="protein sequence ID" value="SPAL_0000253300.1"/>
        <property type="gene ID" value="SPAL_0000253300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836:SF1">
        <property type="entry name" value="GLYCO_HYDRO_19_CAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836">
        <property type="entry name" value="PROTEIN CBG09520-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000253300.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15265" checksum="EAEC106FCAE1015A" modified="2015-12-09" version="1">XGAGENRRIKAYKWFTSYFNVSAGPEKTITCKNMVENFEGIPHNHSWQPNWSTMWKSEPCDCTPTQYNGALPYYDPKVYGDKDYDVINEQNRLRCVYSMYKNPKRFNIDESNSPCIKFKVKLKLSKYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9E4</accession>
    <name>A0A0N5B9E4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9E4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9E4"/>
    <dbReference type="WBParaSite" id="SPAL_0000266000.1">
        <property type="protein sequence ID" value="SPAL_0000266000.1"/>
        <property type="gene ID" value="SPAL_0000266000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="52"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="164"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="167"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="326"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="354"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000266000.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45341" checksum="C2EFEDCD22E0F062" modified="2015-12-09" version="1">MTSTYSRIFHPKFLGALAAGSAGVGLVCFYDQNKNCKINKGCVDPEVIKKLEAAYAKLNGPEAKDCKSLLKKHLTRDTLDHLKYKKTQLGATLLDVIQSGVANLDSGVGVYAPDAESYNTFAELFDKIIQDYHGVDPNKKKQPPVDMDLNKCKEFKPLDPKGKYIISTRIRCGRTLNGYPFNPLLTEANYKEMEEKVRRSLESVSDSELKGTYYPLTGMTKETQNQLIKDHFLFKEGDRFLQHANACRYWPTGRGIFHNSGKTFLVWVNEEDHLRLISMQKGSDVGAVFSRLIRGVQAIEKVVPFKRDERLGQLLFCPTNIGCSVRASVHIKLPKVSARKDFKQICEKLNLQIRGIDGEHSESKGGIYDISNKARLGLSEYEAVKQMYDGVKKLIEMEEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9K7</accession>
    <name>A0A0N5B9K7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Late expression factor 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9K7"/>
    <dbReference type="STRING" id="174720.A0A0N5B9K7"/>
    <dbReference type="WBParaSite" id="SPAL_0000272300.1">
        <property type="protein sequence ID" value="SPAL_0000272300.1"/>
        <property type="gene ID" value="SPAL_0000272300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000272300.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="61282" checksum="A5A5777E519CD64F" modified="2015-12-09" version="1">MDYSEIQDICHKDEERREFIEHLWDLRCGYNNVGIRNVIRRAETMRCKPGTYDIFHKRKFFHSICPDQCLATNLPLGGVIQKFSVCGRYLFLTNVDYSQFIVYDYVGCDNIFNGVAQRPFDKIFRLRHTYNFIKPGLEHVRLHLIRSIILNSPGGKFIILASVRPYTPLDHGKFTHYRTNDSYVESKLFDVFTIYTIDIENNRIADEYSFIQERIKQLPISVFNCTIAALALSSQVIHILHIDKETGKLTLLLKLGRDIHQDDHVYIGAEMHKRERFITGLKQKVLSHVVTKIAPNCLQKLMTQLEVYKTMQLHSVQVISEHELFIKFTCIDLAASYSQKNNCNCAPLHIIYNWVTCEVLKSIKNDVLGLNKTLIDNYVATHHTCNTPTNFMDGPLHSFYPIPEFANIIKDEGLCIPIINSFCCSRSPYLDYETFRLGCGHSNAFSQDAARLKIDVDFLKFYDLVTKGEHKVVRNRNDTNRDNFPAVYLFHPTDPFFIIVDAEEKRRYCYIFVPRNSDIDVINRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA28</accession>
    <name>A0A0N5BA28_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA28"/>
    <dbReference type="STRING" id="174720.A0A0N5BA28"/>
    <dbReference type="WBParaSite" id="SPAL_0000289700.1">
        <property type="protein sequence ID" value="SPAL_0000289700.1"/>
        <property type="gene ID" value="SPAL_0000289700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="159"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000289700.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49226" checksum="0ED58983A983A838" modified="2015-12-09" version="1">MPFSRSYLDTRNDATDRVSQQNNYNSTIKPTSTKNGKIIRKWRYHEGRNRFFCDGRIFMSKEVSLLFLTLFLIITITGLFLGFDGPYLFKNVSPIIPIAVCILFIFVITCLLKTSLTEPGIIPRATSREVMEIDRQNEEEGLGRSARQPKTVTINGINFKLKYCNTCRIYRPPRSSHCSICDNCILNFDHHCPWVGNCVGLRNYKYFYFFIVSLAILDLLILGSSIAHIALVSTAKKAFIESVKETPVSIFISGTCFLSIWSILGLSGFHTYLLATAQTTNEDIKGTFDKKLRPGTRNPFSQGNIFINYFSALCGPEPISMLDARGVYDPYSTITSVSNLPVFMPTLNINNENDNTSISQSVSVNSMNQLNSIYVIPGQLKNNSQMSRHNNESQKHFGNGLNKSSTKKNSLKHTVKEGNYNNNDNDEFSHSIEIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAF4</accession>
    <name>A0A0N5BAF4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PNP_UDP_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAF4"/>
    <dbReference type="STRING" id="174720.A0A0N5BAF4"/>
    <dbReference type="WBParaSite" id="SPAL_0000302400.1">
        <property type="protein sequence ID" value="SPAL_0000302400.1"/>
        <property type="gene ID" value="SPAL_0000302400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055121">
        <property type="entry name" value="HTH_69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22979">
        <property type="entry name" value="HTH_69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn-helix" evidence="1">
        <location>
            <begin position="161"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000302400.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="66788" checksum="CCDDE3A72756D1A2" modified="2015-12-09" version="1">MSTERHSLVVLKPIIRSPTHNVIRIEREQDLNTDEILHIAGGDHAGVIVNKFTGTYNPLEEYDLLINFSVWLTIPGEKSDEKRQEIRYIKFVFNDGIEKELQHEYAEKIFKDIIISFPRDYLTFIKRMLRTMENNYEEIKMIEIDMKFADEDEAIEMPNDYDSEPSYIEVTSGHVQELLEHAFPNSLKVCDMANALKCTEEEINNFLMELTQKSIVEKVENADNEWIRVEKRHIDQTIAFKKQGENFDGKEQPTIAIITSLYSEKKAIDTVIENRHTFHKYRASGESNVYTTGNIGPHRVVATKLPGIGDGNFNAYISASGGTTRLLGNYQNVNHVIILGAAGAVLNFSNVFDSNVNSVKLGDVVVSNSRTFSDKESPSYVYANKYTTDRNTDEYNGYISSLWHPSDTILAQIASQTNDASLMNDWETFTQEIIDTLNESSEDNCFSKPNEADVLKVPVGGGNFVAIPHQNPQRTTSKVHVGPIGGMRPIIENDNDCSKNMANDSINTEYIKTIYYNLKEKFAKEHQLKAIDAGAESVISAIQGSCIGSWSLVRGITDYQNGMSRSGRVWQPYAAARAAGLVKAILERLPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBF2</accession>
    <name>A0A0N5BBF2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBF2"/>
    <dbReference type="WBParaSite" id="SPAL_0000336000.1">
        <property type="protein sequence ID" value="SPAL_0000336000.1"/>
        <property type="gene ID" value="SPAL_0000336000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894037" evidence="1">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000336000.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23558" checksum="9AEC31BBF8B0D613" modified="2015-12-09" version="1">MYCSTLYCILLIYFLEVNFIKADDSKPCTKGGNECNIIQNAKCLKQVEKIFDNLKGDFCGLTCEKDKEKEQCGEDVKCEEMDDIENNKVFSCVKKVECINDAFCKAINPDKPECNLFTLKCFNPNPPTTTNSMTTTTTTTTSTTTTTRKIVTTPSIVDKISGGGPYSCEAHLKYCTDPIWFDLMRDMCPKTCGYTTGTGTGGTAGGEDVYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBV8</accession>
    <name>A0A0N5BBV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotran_1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BBV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000350900.1">
        <property type="protein sequence ID" value="SPAL_0000350900.1"/>
        <property type="gene ID" value="SPAL_0000350900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="57"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000350900.1"/>
        </source>
    </evidence>
    <sequence length="1483" mass="169098" checksum="E441E66A33D9C3BD" modified="2015-12-09" version="1">MMVDEVNKRESDCLLSVRGKKLLENKDERGKNPMTDVNNERRKSRIQKEGKKISIPRTPGTAASLDMLAYALFDPHDCILCPAPYYKKYYEIFTTKNSINLIPIHFEDINTPKLSRSLFESAYLKCKKVKGVLISNPHNPTGSVFSLDQVREVILFCEEKGITLIMDEANAFSVYDKDGKKEFGSILKELEKGNKYKNIFWTWSFSKDMLLPGLRFSLVYMEDRKTYECMDKLSNYNTVNGLTQNFAEEFLHDGEWFDEIQKTKNEELMSNREMVMLKLRELKIPFVKPLGGFLIYFNLSHLDQGILLKFLEKDVYFEHVGGEDFDGYEKGWFAISLSQKKEDLYDVMDKMGNIIKDFCDRKTLQSQRSVSYIMADDVMKEVFQFLDHSKESDREVVRKISQSSDNHLPPNDDSDKYLNKHHKDFIDHIVNECNLSKTEKSTNPQTSTPNNEEKRISPDANAESQQKDKILSQSPATNQENVTKICEDSKPITSLDCDGEKVDGKSSKTEISHSHTPNSDGIDGSSRCTKVMCPICESERKKEKVDDKVIKTGNPIDLEEVFQIKLGERIDNVKNDWIADMVRRHSQRRSKSHEVIGRGITKIDEEESNRELSNDNTKVQLDDNNKVSSEKDLKIDDNMMENGKVIVGRQVLDDGKVGEKRVLQNKIPLEVIFSDRESGNFVKDDVSPDDRVINLGERKNVIKEQVGGENVKGDSLEDGLLTGNKNKGTVIRKEDNFMTLDSDTLTIDSISDIKIEDGDIIIVEEKKTIIEGGDSDKNSILLDYIFNSDNNNKGISNDGNISENRLPSNGRKVIECEKSSSYTVRSIDNTKRQMNGTKTKIDLNQIFLNDGDQKEFKDKVFDNMYVLTKEENYRESINVPSTATITFRKTETNVEAPFDHQERKSKLHTQLIEPTMVSYLSTEELNVNEDGTKIYTESSYDTEIDLKKDEHFDGASVHFMENDSEKLYISLENNKINDEVYMGIMKEKSVQLRGDKFGNVKEELVLTPTSDEEANTSFSYIKIPDTKTTLVIKDNGKSIPQKDDKTKSFTPIDLSIIFNRKKSTSENIEDDNKDTTTKNDSCCEENETAFEGSFSSSNGGRRYLTHEYRKVSSYHVPHSGVEKKIQKKNTSTEGYVVTDDGKSCDSGFTGDKIDNEVEVKVNDKDEWYDDVKRRDVRRCISLKDGSGRRSSNESDNSNDNKSKEWIQDWERTNSFKDVNKKESRERLTSFTEVTVDLSDIIGISIKDNGSELGDSAYLSMSPEMRKKDKRDSGYCRDSSLSSDTRKSYTPKRLSYTYDISSDGMITTPNDAINFLRDCKKDNKYDGAIPNQWNLTNEVIENDSVNKQKFIEYCVTKNEYKSIPPTVNYQPTNDIILDVKLIQKQHGSAVGYYYPPLKDSKSYITELHLVPTRKKDDGGGDCSMVSISDRSNVVSVRNGDGKGVSNENGEKAKKTWYVTSVKKTPRPAFCVSGSLTIDINLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC18</accession>
    <name>A0A0N5BC18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BC18"/>
    <dbReference type="WBParaSite" id="SPAL_0000356900.1">
        <property type="protein sequence ID" value="SPAL_0000356900.1"/>
        <property type="gene ID" value="SPAL_0000356900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF24">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG MIG-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="10">
        <location>
            <begin position="325"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000356900.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61725" checksum="8DD32A98A892D30B" modified="2015-12-09" version="1">MVNKIYYYFDGNTPYVSEFEKPLNEITLGDFKKHFKRRGYRYFYKKEDDDIQKPVKVELFDDDTILCPSGKGPIELFLLPSPENEPIKVQDMSHATLTRKNVHRFSGHGSDYWKKTYKPHLDTPGTYLPSITDIDNSGGQRVSMVTTDYDTSIMYNKLGKNISVDPYTTDTEFTFQSEDDEVYGGGRRKHHKGEYRERKPRQNKRKIKNESVVSTTLNSSLTSHSTPCIDTVYLNLADHSFLGMKVVGNDGXXXXSIQRQMRGMDKTYIEKDIEEYNNGLLQENLSPSMNELSCMDATSINDENSSTKLTCFMDPSIIIHRMIMPNNGITIKDRVWLKITVPSCIIGKDLVCWLKKNVRGLENKKKSHSYAAWLLHQGHIRHMIGHRKFTEQSYYVFNEYYGKRIAMNEMMRAKNESNTDITYCRTSSSNTQGRNENESKNHDSRNNFSPPITSVNDSKEVTINSSNSNTKKLGKGPIEVPVVNNDYATMLDMDDTENTFHDNLYHVVPEYKKSIDQIAKHKQTTSPSYDISKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC54</accession>
    <name>A0A0N5BC54_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC54"/>
    <dbReference type="STRING" id="174720.A0A0N5BC54"/>
    <dbReference type="WBParaSite" id="SPAL_0000360300.1">
        <property type="protein sequence ID" value="SPAL_0000360300.1"/>
        <property type="gene ID" value="SPAL_0000360300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF49">
        <property type="entry name" value="NIM1 SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000360300.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="64678" checksum="238DC956584D7C33" modified="2015-12-09" version="1">MIKGNTSCYQDILKNFENKDTINNTPFSSNSSTSSSKTFSNKMYHNRSVSSPVGNRKPNIPNGTEGTVNTPGQKKHSIALSNTSSDSSTFSTDISMGRHRTSSNKITKMNNPDDAINRTVLKNLKYHNSKNIIQAESHSVDEDIKGSHTNPYPFSRAISTQSFALGLRSNNDSTYSNGQKNIPQMTLYERTLYLLANDPAQQKEVALGKRIGFYRLGKELGAGNFSKVKLGVHVLTKEKVAIKVMEKSKMDQKAQRLLEREIESMEILHHPNVIRLFECVETLSKTYLIMEYAGGGELYNYVHTKGKLPEDVAKPIFAQLISAVAHMHSKNVIHRDIKAENVIFSQPGWVKLADFGFSCKIQENVLLKTFCGSPPYAAPELFKDQEYYGPGVDIWALGVLLYFMLVGVTPFRGDTVSDLKQTILKGQYNMPDYITTFAQHVINRMLDINPQRRMTIEDIKKTYWLSEAKFVDSYVQCSLQPDEKELKSSPVARTLWNQLHEYGITKAMMNDAAGKGARNAIIGTYRIVLFQAQSIEMDKQRVKVRDHIIQLAEKKKRDEKRQQQQSRACSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCU1</accession>
    <name>A0A0N5BCU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BCU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000383600.1">
        <property type="protein sequence ID" value="SPAL_0000383600.1"/>
        <property type="gene ID" value="SPAL_0000383600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057086">
        <property type="entry name" value="GBD_Irg-7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057085">
        <property type="entry name" value="Ig_Irg-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006582">
        <property type="entry name" value="MD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324:SF2">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23623">
        <property type="entry name" value="GBD_IRG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24415">
        <property type="entry name" value="Ig_Irg-7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00604">
        <property type="entry name" value="MD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894305" evidence="3">
        <location>
            <begin position="20"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="1930"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1444"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000383600.1"/>
        </source>
    </evidence>
    <sequence length="2117" mass="233810" checksum="37D6AEC5891807D4" modified="2015-12-09" version="1">MYKFYCLFVLAILTSITNADEHLNRLKLANAFAPLNSNDFLDIENLAANGPYLSCPAGWTGRFCESPICTNKSVPSMPTDTSSILIDKMNFQSGCVGSIEFPVDRSMKYVMITAHSDQGSPTINLTDSNGQIIPYVSVYNSPGQAVSSYANLVPGAFSVSVDNGNTPTSFCIVSINSASQLVVSGGFVSNSNDDTPHDGVSGASEYFTVQPLNLPSPGFIGSVKIRKNGNYNPDWVAVLTTRFGCGYAYYAGMYTCNEKDSEFMYTIDGIDDNGYPFRRSNTFTCLAPYNPPTPPPVTQPPPTECMNGGTIVGNTSTSVYCICPEYFTGQTCQNVACVNGGISINSGLACDCPTGFSGLNCQDVVCPDAHQTGFGTDYKSLIIVVRLSQTIKSKIELMISSMQMNDLIWSINNKDVYHSFVLVTVSDGGITSKNDFRDINDFYDNLRALENSPTTATGCTDTIVGGIESVFDTQLIYNKSPIYVFTDVISSPDEDYLSVMHRNTARKFPIHIFMITDSSNNCGFDPMNSGFEVLEYVSRRSGGLAYQLPTNDFVHFYQWVQSSTAFQMNMVLFGDYRNCLMKGYTTFFVDNTDKSVFILATGTNLTLTITRPDFQVISPLLNAHNGDSYIWEIYNQDLMIGEYLAIFSTVGGGTYPCSYRVMTESKYELFLGISNEVTNDVSFFDPVYQRASHLVAQLGGLQNNINDPLRLFAEMTIYSTDKFGNVVPVYFSNGIYRDQCDYQLYFGAYSCRVPDQELMITVYADDLNSNTIQRSIPAVCADIVLTPAPPGTCQNGGVQNPYNTSQCICQQNWSGQYCDQINCQNGGQQFNGRCNCPTGTGGMYCENIKCTDRSTNVQFINEERSLVFIVNIEYSMQQAVNELNNKLPDLIRDLQGVSSTFITQYILIAYNSTYNVGQYNGTYSGDFLTAFNNVAQMPLLSDPKANCNGQLMEALSLAGLYNQKNQPLFFIFTDSDYLNSDFAQSSYNNILINLESLQSTINIVIPSTKICNNGDRTTTLSADLTSLVEFTNGDVMFTVTPGDYLSYIPTIHQSGRFGAFSSLDCSINPIIYYLPVDQWSQSFTIAAHGSNLQISVSDSYGNDATANYLNQILSDSSNMINQYIIPCDSKREISRKQYCYNLQTSRLAWGDAQLKCHQTKGSFLFDLFSPQKETFFDGQIGTIGVWMGLRRGSDNIWRWDAPDGVKSIQLGSYSNWATPPVSGDGLDCAYLQKDATGQSKWYRDACNATYNFICQKHKYGQVISPDMDSANLLPAGIWKVKINGTGQCYFNAMIQSQIQVFYGFVNDIHEDIPQSVANLGSSTNRYIATATGLDPINTESFVNNVDGNLNYAFMYKYNANSTRPATMLTPVTFQRREECSYVSVSQTFACPDKGSSILSHEYFVKFSGVDQFGNLFERLSTSICASPITKCMNGGYLYNGQCICPPNYTGSRCGTVLCFNGGQINEAGTCTCQQEFTGVSCETPMCELKHPQDFGDNHKTLAIVIEQSYGSTSMIKYLIATLKNTVQQITQKNQLWFSNYILVPFDQTKNSGVWAPVVASSNINDIINGLKSIPSGQCADSMPCPSGSSCHRPIYRVMNYLFSRSDFNKPNSQVLLFTRSGAEDYDYYDLFTQMQQVKPVINVIIPDAASPCGQGFDTPEARGLTRLAALGGGNVHVMTSRQVATQLLPLYFPTLYTTNLVEVIASTRNCTNDEAIFQIDSTANDFTISYVGGYDAQLKLYGPDQKQITLPTPVVSSDTNKIYVIKADSSSYLKSGTYRLFTKTSSQFCNALIHVNSSLEVFTGYAAVTDHMNGATQDDGYFAPIGKIGVKNVLMFHANNLNVGQLTFVQLYSERGLFFTSEIKKRDACSYEYYSTQTFECMFGNFEVAIYGVDDKGNNFRRVTSGSCLDEMPERDPPAAFCDLGLVKQDFLFVMDTSVNKYFSNLKSSAIGIVGKYYVQGLNNTRVGGISVADQSTLNFNLSQTTTSDGLFGYFNTFQPTNLTGQNLASAFYLARSVATDSNSGYRTDTSVKHTIVYLTSNDNYSGDDALQAYKSLKRSGSWGLLTVGLNVQSKAPIEVLNGNTCMYVSSDADKFQTNAVNFVQSHSCRRFSRCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF3</accession>
    <name>A0A0N5BDF3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BDF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000403900.1">
        <property type="protein sequence ID" value="SPAL_0000403900.1"/>
        <property type="gene ID" value="SPAL_0000403900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000042">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012655669" description="Metalloendopeptidase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="113"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000403900.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60772" checksum="495F4C532D7F2429" modified="2015-12-09" version="1">MNLFLILVLSPTILSLSLLPIPDISANAVKKQYDSFSEKFLLPQDFDLAESTPVRQPTEKEMDEMQNGDLFEGDIMGVPDDEDPTLYIQRDLPLGELDAFDHIFRTPYHSALNLATYPDKLWVDGKVPYMLEEGMTPSQRAAIAQAFEEYKSKTCIRFEPRQEDDEDYIFIKRNKGFGCSSYVGRAGGNQTVSLEIGKCFSKGIIAHELMHSIGFFHEHSRTDRDEFVKINEDNIRPGMMRNFEKYPRKIIDPLGMPYDYESVMHYHKLAFSKNGKATLIPKDDNAEIGQRYKLSDVDAKKINKLYQCKEYSIKPETTTDEPDEIITTRKPKTTKKPEKERFTRWPTKKQKTTPSPSTISPTSTTTEYIITEETTTTEKAVETTTKMEETTRDMEITTSSIGTTTKLNKKNKEKCEDLNAHCTMWEQLGHCQHSTKYMKHYCRKACNFCDTNISSETSSEVPEEKVVEGEKVIVTSTSYPTTRKPSISGKKPTIKACVDKNLFCGYWAKIGECKTESKFMKIFCKQSCHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF6</accession>
    <name>A0A0N5BDF6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF6"/>
    <dbReference type="STRING" id="174720.A0A0N5BDF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000404200.1">
        <property type="protein sequence ID" value="SPAL_0000404200.1"/>
        <property type="gene ID" value="SPAL_0000404200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000404200.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13425" checksum="6FDB905AE8A6B7E2" modified="2015-12-09" version="1">MSSCGRAKGRRPSLNDWSDSMKSHQSMDFEHKGDNGNNCNALIVEICEDEPNNSNNPVDFVFVTNGVTLKDTLGPYLKSRGISMDKVDCMLENSNTPIPDNSEAIYLVGRKIFVKGMFNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDH9</accession>
    <name>A0A0N5BDH9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDH9"/>
    <dbReference type="STRING" id="174720.A0A0N5BDH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000406500.1">
        <property type="protein sequence ID" value="SPAL_0000406500.1"/>
        <property type="gene ID" value="SPAL_0000406500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047822">
        <property type="term" value="F:hypotaurine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000406500.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60606" checksum="A62EBBC7425B7418" modified="2015-12-09" version="1">MVKVCVIGAGASGLPAIKCALESNFNVTCYEKSNDIGGLWRFKPYPCPDEGTVMRSTIINTSKEMTAYSDFPPPEGAANFMHNSELLKYFRSYAQHFDLIKHIKFSTIVVNIERHEKFDHNGKWKVTAKDIETEEVTEEEYDSVMVCTGHHTTPYWPEKFMGQDYFQGKIMHSHDYKDFQEFVDKRIVVIGIGNSGGDIAVELSKCAKNVYLSTRSGSWIINRVFDKGEPSDQVYLNRFNYHVRKLIPSYVENGLLERKVNQRFDHGRFGLKPNHRFLSAHVTVNDELPNRIISGTVIIKPNISSFGEKEVHFDDGTFVEDVDVVIFATGFSFTFPTIENGTLIDVKDNIVELYKYMYLPRLSPHNTLCIIGLIQPTGSIMPISEMQCRVHCSVINGTIILPSQSEMIKDAYKCNKRNMKIFVKSRRHTIQVHYVEYMEELGKILNVRPNLLKYLFCDIKLFKCLFFHGLYPYQYRLNGVGAWSGARDAIIGAEERTFNCTRTRKTPETMKSKPICKIHLCRIVCFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDV7</accession>
    <name>A0A0N5BDV7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pol polyprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDV7"/>
    <dbReference type="WBParaSite" id="SPAL_0000418500.1">
        <property type="protein sequence ID" value="SPAL_0000418500.1"/>
        <property type="gene ID" value="SPAL_0000418500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000418500.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11203" checksum="AC078E081FDD944C" modified="2015-12-09" version="1">MYENIGDTISSERKKAIDYQIKTKKIINETNLRKGTLIMIQRGKSSKFNSEFIGPTKVILDNEDSVQIRHPETKRLTTVHKEQIKLLKNQSQAQMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDZ2</accession>
    <name>A0A0N5BDZ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDZ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000422000.1">
        <property type="protein sequence ID" value="SPAL_0000422000.1"/>
        <property type="gene ID" value="SPAL_0000422000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000422000.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31973" checksum="8CBBCC1F49DA44CE" modified="2015-12-09" version="1">MEHIQNKIHVAIFVSVFIIFIYLLTVSQNNKLSINKFEESSLVPIYFNEDKLLPELFEIAFGSGKNAGTQDKFIRETLHSLHNKKNYFNETWKLYSIIENPLDRFAATFINNCLNKSNKIEDNVCYGCMNNPTCVVNYLYKNLKKLISLQNHFYNPNEADRMFMPYYWRCNMQRDFNLFQMFNFTNSTLFNAQFQKLFQKKNVNHKDVASVMRRIKEVYDSDVNESVFNEKKSHIIKSLVDNHNVLLQFMSIYSTDYQYFNMLFPKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEF1</accession>
    <name>A0A0N5BEF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein bicaudal D</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEF1"/>
    <dbReference type="STRING" id="174720.A0A0N5BEF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000437700.1">
        <property type="protein sequence ID" value="SPAL_0000437700.1"/>
        <property type="gene ID" value="SPAL_0000437700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000437700.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="85754" checksum="BD9D89283EB50D5C" modified="2015-12-09" version="1">MEKELESLRAEHARLSAALKEATAEKIQAAQVGLKTVEEKEKVELKLTQLEERHQLTVMELENTKQQLQNFREERSRAALSGISEEESLLKETSSRESHLKETIANLENEKKNLVIEIKNLTDENKRLNQLYTESIEKCDQLEAQKKKYHNELKEVKIREQQLSADVNELEEENISLQKQISFLKLSQVGFESAKMEVKRLAEEVEDYQMAIEEANNLHTLVQKQLEEALQQAQQEREQKLSYKNELEFLKMSEHKNHLDMLLEMHDQPGNNVSALNRFELSYTEGSGDDSLGRQLMGTGNDLFSEISNDANKKVQQLETKLEEQKKSINDMKKAYVRAILPVLKELNVSSASENIDLDYLQELCNNAVSRLNEVNTAKSVEKELEKKVEQIKNNVREVILFGGKKYAECVVAKDLLISFGKQMNSLYKNLVGDQELESNRHVQEITNKLSSLGVYDFTENGKEESKVKEVKEGEEEEEQVVQTEEQTQIVKPLKSKLYLQEVEKVLGGKEQLATFINEKDCQEDFVFGTDESFSKVMEYTQDLVKITTRTALNAVNSKTKIEDTDVKEIISQNMKLKSQLATKREQIVTLRTVLKSNKTTAESAIASLKEKYDTEKAISHEIINRLRKELKILKEEAATFASHRAMFHSKNEELKEELKSAKEMQRMAEEEKKTVSALLRMAITQKLEAKQRLENMEIDRERQSFKRERGNKSFKSPNTGGQESKEVKTVRYPTSNNSTPKSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEI2</accession>
    <name>A0A0N5BEI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEI2"/>
    <dbReference type="WBParaSite" id="SPAL_0000440700.1">
        <property type="protein sequence ID" value="SPAL_0000440700.1"/>
        <property type="gene ID" value="SPAL_0000440700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000440700.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42282" checksum="9B5EF3748D54A72C" modified="2015-12-09" version="1">MENGNSTESVYFILKVGKYLPFVYLNITYVELIIHILLSLLSYSLYIFIIYSIYLFQKNDSLYKSVFYKITMVLGVVEILGHILQFLVFYEVRISPLVEYFALHSPPAWQFTVIINGSGFGLISQATYSFYLSLIRFFAVYFPLSNKMVQEKCFYISHALTVFLCGTVILCSPIYYGNYIIDKDEIMYTENKSTGTYQSRSLFLNRSNRHLYTTTLTGGCTIIAVITNAFTYIKFNKKKSTTFIDSASQSIQNKNGRSMNLFVICLTVKQLLFLLFNILQAWKPILYPNDNSIYHISQGIKPWVMHINFFFSPYAMIYFNKKIRLKLINTILCRKINENNDTKTAFFNTHHVTSKRQQIKLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFB1</accession>
    <name>A0A0N5BFB1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Entry-fusion complex component</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFB1"/>
    <dbReference type="WBParaSite" id="SPAL_0000467900.1">
        <property type="protein sequence ID" value="SPAL_0000467900.1"/>
        <property type="gene ID" value="SPAL_0000467900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894275" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000467900.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12441" checksum="36883B235EF4561E" modified="2015-12-09" version="1">MIILFVSIAFLSTIISHLIICSTEKPKANSTKVLRNQEDLMKYDINKFKNVDNFSQKEDQNACENNEENKNSQIKTSEPFEVPCFIPSETYKTQLKENDYEMIVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFS7</accession>
    <name>A0A0N5BFS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA_13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000483900.1">
        <property type="protein sequence ID" value="SPAL_0000483900.1"/>
        <property type="gene ID" value="SPAL_0000483900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000483900.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="71677" checksum="1876B033E45EB299" modified="2015-12-09" version="1">MPAKSKNSYLNLKFAKVTREQAMKRNELCKNLQVLLKKKNFSGVEEMFNNLLDELFQAQKNNIKQSLQPEENDSSFAEEDKENPFLNVSDTIEPSAKKIKIDKEIFSTRLSDTQRRYFKKLRETIISDGYDQIICQEAFDYLAKSFKVKYTPIETRLTTKDCLMLQITCGLSKKRLLEIKSIIEKSIGTKIFPTVDEINNSWIEIKDDFEVKAFTLHSVKINGKIHILDGGNDCNTLNSNEIYGCYNSNIKKDLISRYESLVKSGQIDKNKDTIDICITGNSESNITKICAFFKTQSSTKAHSNILPLAIYKGSDAKNVLRKVTLMFADQINNLNELPGSSKNVKINWFLVADMKFIYNIMGNRTAVSKRPCPYCDKFVGKQLWEDYQDSCDKAIENELYMTDPVFTNIPVERIIPPMLHIFMGLFTDLFKKMKNTLENPTSKTALVKLQKELESINVCIKDYWQTFSGNHIKKILNSSTILFEKFTNEEMDAFNLSEYKEIFNTLSLIQGLCIADELTETQQNELNIYIENLKNLYKYSTVTKEFNVTPNCHILVDHLVEFVGVYGTGSYFSEQGIESLHAWLNNHSSCFQSITYKPTEQCKRMFYLMRVANNCHDSRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFW1</accession>
    <name>A0A0N5BFW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFW1"/>
    <dbReference type="WBParaSite" id="SPAL_0000487300.1">
        <property type="protein sequence ID" value="SPAL_0000487300.1"/>
        <property type="gene ID" value="SPAL_0000487300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000487300.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24738" checksum="75F17ADF722A96C4" modified="2015-12-09" version="1">MENNSLDANRRRLRSGRILSINDKNEETSDTDMEPHDNTRKRNYPEDEKVKDQKVKSKKNKTTDSAKLNEEKTNVSDEDQGQEGDDKQCTFTRSSNVSSEESSQQENVASPFEEEGFFSSQSSPTATNQQPPEPRTLPPSQALQIDTEGLRVTPDFDITTTDAEILKNISSGMRNAPSRKKRTPKKNKLLNYLSKPFKFTSFMSSLKRDSGYDDSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG96</accession>
    <name>A0A0N5BG96_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG96"/>
    <dbReference type="WBParaSite" id="SPAL_0000500500.1">
        <property type="protein sequence ID" value="SPAL_0000500500.1"/>
        <property type="gene ID" value="SPAL_0000500500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000500500.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19776" checksum="5E1D57A61C152ABA" modified="2015-12-09" version="1">MSKRINRSRRSDQYAGCEKRIVDLLSSSEASNFIEIKDNNEVVLKDGDEIVASEGDNSVVVEENDNKNCNPNVLEDDNDKKFDPIVLGDDDDEKCNQIIPEGSDDKKCDSRSKYGRYGKMTDKYFLCEGCGFQISRNGTSAIRNHIRRRHESWWHEFLSNENEKEKNNILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGC6</accession>
    <name>A0A0N5BGC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGC6"/>
    <dbReference type="WBParaSite" id="SPAL_0000503300.1">
        <property type="protein sequence ID" value="SPAL_0000503300.1"/>
        <property type="gene ID" value="SPAL_0000503300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000503300.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17151" checksum="9B9CFE7216C91AE0" modified="2015-12-09" version="1">MNNNFQRHSSQSNYSLNVDTYTGGYYTQPQKSPLTKPVDQLAYEIPSNKYARNPWSYAPEFLKVFSDLRVHEGGKAVFDCILIGTPRPKVCWLFNDEKLTFKDVIIEDTADLCRITIPYVRPYHYGTYTVLCENEVGRAVTSGELLSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH46</accession>
    <name>A0A0N5BH46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH46"/>
    <dbReference type="STRING" id="174720.A0A0N5BH46"/>
    <dbReference type="WBParaSite" id="SPAL_0000529100.1">
        <property type="protein sequence ID" value="SPAL_0000529100.1"/>
        <property type="gene ID" value="SPAL_0000529100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="201"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000529100.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="75601" checksum="23BBFBDB59DF225C" modified="2015-12-09" version="1">MKSEDIFNNHIYINPCSYINQHHLDIIIEEGENDSYSSYYQVSKSADSINFNEYGVGHQTLNKSETEINKHKNDVIKNHFLKTPNKSGCTLIDIDFEGILKLIGGCNRWQILIFLIISLHQIPRAMFNLGVIYMMYQPDHWCKIGNFTKESVDNHMFLINTIWDWSTILESGLLYPIIDNENYPKVYKHDQCNFYSRNNDEIFEIFKDINFYNINNTIYSKDLVNSSVIKKCKSWEYDTSVMKETVVTKFNRVCDNNWSRAHVHLSYSIGYLIGCLLGGFISDKYGRKTTLLTFTFLATFFALLLPSTIDFESFLIIRLLLAICNEASNLAAYILCMEVTGVKYRAIVGCLLQIPWALGYILLTFMAYISRSWIFIQYFTTLLSAISILFIYFIPESPRWLMVIGKVYNAELIIRKASKINKKSLPSDLELVTHKGKNPLISKNKKLNFLKLLMLSNMAWKNGIVFFIWSSAALVYYGLVIVISDQSKPDRLIFSGNFFLNNTIAGIIELPTLGICLFLMRYGRRKAEMIMFISTGISLIMSMIFIIMEDPKTSFTFLMLSKMFIQGAFNILYIFTAEIYPTIYRNSAVGVSSMIGRVGSALSGYVAVSFDFTVPYIPMSIFAFLSLIAGAMVMFLPETKDVPLPETIWVSITFVVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHS8</accession>
    <name>A0A0N5BHS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoporin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHS8"/>
    <dbReference type="STRING" id="174720.A0A0N5BHS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000551300.1">
        <property type="protein sequence ID" value="SPAL_0000551300.1"/>
        <property type="gene ID" value="SPAL_0000551300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="761"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000551300.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="102541" checksum="F40403E7A09A1A69" modified="2015-12-09" version="1">MKDLQVYLKPSLSNYPTHIKGLFCSIIDRNELVIGYDSSVNCGWALRDKELYVWRDDLTANGQSGTGERNTLESLQAYKLNAPITGLVFSDKHVAFYKNSAYPTPSVIVVAPEGNVRFWPSLEEKAVSLSIPLDGDVVVEVFFKVIDDSSSFIITTASGDVYQIPLLPVNETKIATGKLHVVKLNSKHGTGLTSRLSRSLFKGDAEKNNYLKASFFTEDNETLHLEDLSLIQVFSSTIRGYNVGKCSSIWEFDAGSAVAKEFLKHYEGVLTIDEPGSLHTRTHIIDAFGDNSCIYVLFTTRPKVSFSSTVALYLGRVALPEDFRDGISNFDWLSPVNLPSSIVQTISNNNGWDKIKIAYFQQTGLFIYCRDIIANFKIETQTFKSVSIVYNCHLELKEKCFGYKVIGETLVCFAELDGPAYIRLLPIGFEASFVEAKKMDQYLADILKPSRSKKPLYKLLYSGFLNFCQFYQDDPKVDLLEEFKNTGTIEERGSTVVDMMRSLVNSSPEVDDGSKKTSGSRKSRGIKSSKTKDMFGIQNQLEDKLALCKIFIAFIKNQGLESNVCLGKTQHLADVVEMMELLQCASAIFEFTSPESTPYIYEVIHSCVNQRNERDQSLSVIQTFYKFITEVDEIFGHSYVFLETILKSDRDTEVIDKAMEVIGIISCILDRIKSYRSEEWALVVRTSKVRSWTSRHGFLGNLLKIQKLMSGIIDDVATRRSVLKSFKSFYITIIEFILEEQAGVKDIVNSYLIRNLIEIGFIDAGITNAEKYCDFKTLIAYAMGLDESDRVATLEKYKKKFASKNFEIALYDYYRENQMLTELLNEKSPNVDDYLKSYDAINWMRHVDNKEYGKAAQCLFNAASGLQANSKREMLLLLGKLSCYCEREENVNLINEFNSQLYGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI61</accession>
    <name>A0A0N5BI61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI61"/>
    <dbReference type="WBParaSite" id="SPAL_0000564500.1">
        <property type="protein sequence ID" value="SPAL_0000564500.1"/>
        <property type="gene ID" value="SPAL_0000564500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000564500.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="52107" checksum="FA4E28AB35A8AF13" modified="2015-12-09" version="1">MELAPSTDWFSTNTSDIEALGKFFSDPNLEENWNDENIKKVQLAFIHLYDKRNCNLKLLETLYPLVKDHKKFPVAVAKCYRSGNLDSATLHYYLSHFIEDYRIGNLLTFYNFIKYYFPVKARQILKHTKIAEIDGLYYDKSISAVVFNHEQLSKPLIFDNELSLSFFLLIMYELFANPQKNGERFWRTFFRLIFGCKMPRCGLPILYNAFFESIPPKPDDWEKRASEGGNPKKSGPRPGRPPKKRKYDETEKMSADFLATIEKDTINCGDVPLNIAFNSLTNQFNNATSIASIEYWKGKYEAERLKNLSLEERFNKYAEQRDAEINELRTKFDDFTKQITLKFERTKKEYEIKEKELAKKQASIKLLKRPDRQSHPTVVVFPKRPILSQKGSFRFGNQSTSPMIPFMKVRKLNDSIYQPTSDVATHPPPRSIARGSNLHRSSVEESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIE4</accession>
    <name>A0A0N5BIE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIE4"/>
    <dbReference type="STRING" id="174720.A0A0N5BIE4"/>
    <dbReference type="WBParaSite" id="SPAL_0000572800.1">
        <property type="protein sequence ID" value="SPAL_0000572800.1"/>
        <property type="gene ID" value="SPAL_0000572800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894420" evidence="4">
        <location>
            <begin position="28"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="5">
        <location>
            <begin position="36"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000572800.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="87248" checksum="1DFF75ACFDC9FCE9" modified="2015-12-09" version="1">MRKEIFLYIKNIIILILVSLLSGSICTSRIETGKEDNNVIFNDISTDKSLIINLNNIESYLDHLKILSTDHNNYVVVGGRDKAYNISIQTGDVLTSYTWISSKKDQEECIAKGRSEEECHNYIRVLSPEVSSNRTLICGTNSFKPKCRVIEGNMREEAGNIFQFPGIGIVPYDPSFESTFIRDGDELYTSSVTDFDSMDPLIYRRNVTVSNQSDLGIRTVKDDERFLNSPHFVGSFMYGEYIYYWLREEATECDNCDPIIYSRVVRMCRSDRGGPRRYANEWTSFVKARLNCSISGRYPFYFDQIESISFVKESKTIYATFTSSLAGIAQSAVCGYDLTMIDKIFSTSPFMGQLLQGNLWRYKKELNINYKPGSCINNSKNLSDNEVAYAKRNTLVKEVIPNKFKTAQVTTMGHGEDRYMAVAVEHGKEDILYVGTDNGVIKKMIVKNSNEENVIENIMEIKVSTKPIKDLLIVKDYLVILEDGIIQKINLDFCLTLSMSCSKCLDKNHISGCLWNSKENVCFDKSNLKTNQSSIFTEKSSCPDFLLTTTEESLTNFIPSTLLDVPKDRTMESIKEEKEYIKRSGFFSNEYSFIIIIIFISLLVIIGFLLVIIILRKRDPSDGDKSEKSLSIATSSLSNDSSRNSDYMKRSTSTGVHDIIDAYDTNPYGKVVNIRPIMTATPFIPPRLIDSSIPDSMTPRLSANNDEIALQIDGHSTLLRTSRSQHYPIIGDNHSQYNQPYVTNLNKLPSSTDNSYHSSTLKSDKYYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIZ5</accession>
    <name>A0A0N5BIZ5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIZ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BIZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000592300.2">
        <property type="protein sequence ID" value="SPAL_0000592300.2"/>
        <property type="gene ID" value="SPAL_0000592300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000592300.2"/>
        </source>
    </evidence>
    <sequence length="553" mass="62286" checksum="3DED94229F985047" modified="2015-12-09" version="1">MTSSLRNDETFKHLEKLYHERKANLNLVNFFKNDPHRFNKFSRSLTTPDGAFLVDFSKNLIDEDIFNSLINLAKSRGVPEMRDAMFKGEKINFTENRAVYHIGLRNRDNNSPHIDGQDVNKDVNDVLKHMKQFCSKIISGSWTGYTGKKITDVVNIGIGGSDLGPLMVTEALKHYQVGPNVHFVSNIDGTHLAEVLKKINAETTLFIIASKTFTTQETITNAESAKEWFLSKAGDPSHVAKHFVALSTNAPKVKEFGIHESNMFAFWDWVGGRYSLWSAIGLSIAVFIGFDNFEKLLEGGHFMDKHFKETPLENNIPVILAVLGVWYINFFGCETHALLPYDQYLHRFAAYFQQGDMESNGKYITRDGEKVDYNTGPIVWGEPGTNGQHAFYQLIHQGTRIIPADFIAPINTLNPIRSGLHHKILLANFLAQTEALMKGKTPDEALEELRSSGMPQESIDKILPHKVFTGNRPTNSILLQKITPFTLGALIAAYEHKIFVQGVIWNINSYDQWGVELGKQLAKVILKELNEPGDVSNHDSSTNGLINFVKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLU0</accession>
    <name>A0A0N5BLU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLU0"/>
    <dbReference type="STRING" id="174720.A0A0N5BLU0"/>
    <dbReference type="WBParaSite" id="SPAL_0000688600.1">
        <property type="protein sequence ID" value="SPAL_0000688600.1"/>
        <property type="gene ID" value="SPAL_0000688600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000688600.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31766" checksum="4BA41FAAF029598B" modified="2015-12-09" version="1">MIGSLTANDRVNYVNKKQDNVHSIQNKFKKVNLRKPLNLRTTTGRKLLHRRTTPRGTALRKTSPRKPLTPTTTRKVLPNNKPSTKKSVLPTTRPQQKPKTTTTRKTQTSKATKSSTIKPTIDKSKTSPLMTTTSVTTTPKHNDLSKYINKSINDINELRVKYGRKQLDVDNQLAGEAQNYSDNYVKNNGTLEPSENEGMLEYIYFNNELNNFDAVNYWARNDDNEEIDDSWEKFLHPEFGQLIAKNATHIGCGIDKTTHFIALFCKIHPAWNADEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM01</accession>
    <name>A0A0N5BM01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vigilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM01"/>
    <dbReference type="STRING" id="174720.A0A0N5BM01"/>
    <dbReference type="WBParaSite" id="SPAL_0000694800.1">
        <property type="protein sequence ID" value="SPAL_0000694800.1"/>
        <property type="gene ID" value="SPAL_0000694800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22417">
        <property type="entry name" value="KH-I_Vigilin_rpt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22411">
        <property type="entry name" value="KH-I_Vigilin_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="369"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="439"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="511"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="585"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="657"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="727"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="803"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="876"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="955"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000694800.1"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140289" checksum="94F3DA12C389AAF2" modified="2015-12-09" version="1">MNGQSEFTFDSPSQPTTGFSLENNENTGKKNNVTMNGEKKDKVVMDYSTDFPSLPTAPTKSAGGNQSAWGKQPVLKSTLVTEFIKLSSNERAARGFAKNDGSVPTETKKCKEIASETGCKIDLSEAKDGSLSIMITGKQKNVTEAQGRLIRELQTQGVREIKIPKEHYGFIIGKEGSILKKLENEFYCRIFMPNKEDNKDFIKITGPGNFADACADKILSISSERSKQTSENLEVEKQYYPWIRGAYNVNIERWTENGNVKVNIPPPNVDSNKINVTGEKEAVTKVVNEIKKIYNEKKEKIKTVTTKIPRSQRRFVLGNKGSGIQDILKNTDCIIEVPAEDDDSENITIHGTEDKIILALSAVYTRATSIISTEIKAPQWLHKYLIGPKGGNLQNLFPSREKLKIEFNDNSTIFLEGPPQEVSNGKQILSDEIDKLLSTMDSQVVKVPIAYHRHLVGKAGTNITKLRDEFDVNVVMPNENTNSEDIVVEGKKDGVKKCIDQIKEVVKKMENEKSRDIIIEQRFHKNIIGNKGESINKLRQQYPSVSIGVPDASSKSDIINIRGNKGEVDKVHAYLTKLQKELIESNFQESVPIFKEFHKHIIGKGGSTINKIRDETSTRIDIPLDGSSDDKIVVTGKKENVKKAVDLLTKIQNEQSNIISVNVPIPSKAATRFAYTGRRLLADIEKECENVFFSLPKDKNEKIVIRGPKEYVGNAEKLVNELLNTLNEQTEEASVKAQSSFHKFLIGKAGGKVKKIRETYSTVRILFPDEKDEKSDIIQIVGKKDEVQAVKKLLEQQIEELKQTVEDTIDVDRVYHKHFVSRGSEVLKEIQTSNGNVQIYFPKISEQSNTVTLKGSKDCVESAKARIEEIVEDLKAQVTIEFEIDNKHFRSILSNRGAAIHDISKQYNVRIKFPERNVVDEIKEDGKNLANIITITGNNAKVNDAKNDLLALVPITKEVTVSREHHRSLIGRGGEGIRNLQQTYNVNVSIPQESEQSDIITVSGVANKVDACIKDIEERIGEFEKIAADRQLRSYKVLISVPAKYHQKLIGRRGAAVNEMRNKFDVQISFPKDGDAPDMVTITGYEKNVNECKEEIEKIVAELDSMFSQEVELDPRFHPRMIGTGGRALRKLCDDFKVDIRMPSKTDENPSLVVVSGKNEDDVFNCIEELKIQEEDYVELLIERGQYYTPTTNQSSQEASKSSRTVQITGAPWQMDNEEQFPSMSSNTQPANSTGAPVLSGVWGARLSRTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMX5</accession>
    <name>A0A0N5BMX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMX5"/>
    <dbReference type="STRING" id="174720.A0A0N5BMX5"/>
    <dbReference type="WBParaSite" id="SPAL_0000725800.2">
        <property type="protein sequence ID" value="SPAL_0000725800.2"/>
        <property type="gene ID" value="SPAL_0000725800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000725800.2"/>
        </source>
    </evidence>
    <sequence length="457" mass="54486" checksum="BED8AD22935FBE35" modified="2015-12-09" version="1">MPMEAENMMRKKEYLLEMCHDITVFSNEKHCFLYFDSMIKMSMKQEKEIIKRDSNVLIKPFKNDLDCKKLLEGEKAYIDKVKKKRIVYRESNVPMDCESIYKRGFNKNKILSTIEKKYSLAFALNVYKNYEVIELKLLSIYSPNNHYCYMVDSKNPKLYNQMIQLEKCLPNVYVPKIQYDMKSNGENTGISHFQCMKRLLKTKFDYVFLLQNDEMPLKTNRELIEILETMNFAIDMKIIINKHSINRRVDHKKSWKFKDLNIFLDGDIRKENATIMNQTIEFTKGLVTTGLPRDSVDYLINKLNITTFLKQLNTHLYGNDKLTWQTLLSSDILNVPGHVPRKHVMNYFSRPYYFSKLVVYAGARCPTGSFHHSICSWGVEAIKDLLDVRHYFLYGFREDFDYGAMMCYGEYLYNKTNFEEYEKPDLWFYYNSPSSIYKRLSLTHNMSLIEDYKRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPQ7</accession>
    <name>A0A0N5BPQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPQ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BPQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000788300.1">
        <property type="protein sequence ID" value="SPAL_0000788300.1"/>
        <property type="gene ID" value="SPAL_0000788300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000788300.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="55037" checksum="2EC85C3468B970CF" modified="2015-12-09" version="1">MKREPKTKNLDSPGIRTEKTSKSCNYKYDPYSRPLPAELFNVGYPEPPSMNPLFNNNNENVPHVVQFQPISNFSMNCNYQNFARGTKPTLNSRFSTITSYDPNNSGMYNPFNMSTPWNPNLINMGCHIPVSSIYSQCTTMNQHQKWRIIKTGSATLMNTPNFNSQHDAKMLRVSTTSSKIDKETIINIMFRRTSREKHMIAVQYYNLYNETLASRFKVKIKGKLYKVLKLVMECEIQRNVKDLYKALEKEAIDNAIIIEIFCGKSKQYIMELKELYKEKYGKSIREIIRERTDSGYQRFLLGLVKGERDQGALNLDHVEEDVERLHNDGKGIHKLEDEKFLLDILYKRSFEHINMVINRYQNLVHKDIIRVIKEWFYGDLKVMLLMFFDYLNSPSYYFSKLLKNYLEDFEDNEEEIIRIFLNRAEVDLEIIQQEFNENNSKTLEHQLAASSIGSLRQIFLTMLGHAIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPT9</accession>
    <name>A0A0N5BPT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000791400.1">
        <property type="protein sequence ID" value="SPAL_0000791400.1"/>
        <property type="gene ID" value="SPAL_0000791400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000791400.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="46577" checksum="754CB5658974671D" modified="2015-12-09" version="1">MTMFFEKNINPLIYTKISYWRGIETLKKTTLMIVGEKGTGKSTFANKLLKAGAKNSDIKMFPQKSINFIHYSLKENKWQCPFEKKYFELTKWGSRLGRTFTKYNTTICYKEKNEFLDQYNIIDCSTFESKTNKIVKRNITVTESENVTSNDSFIKQSNIPSENEGIISINEMNEILFSRMDVITVILDNKKFSPTLNNLIESVNSFGKKTLFILNHSDKAKSQKELELKKEILRWYTMDKVNTDTSVRIHCSSFAEKSRIEEVKLFVDSETKKIYQWLDFFKATTINYRVEDILKDFKNSVSQLLMLFIMSRKDKRFINKDESEYQTYINEAQKLANINNLPFDNEFIKESFTYTELPPEKKCVITMFNSDWRQLPEIEYFIEDEKHLDKIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQM6</accession>
    <name>A0A0N5BQM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">40S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQM6"/>
    <dbReference type="WBParaSite" id="SPAL_0000818850.1">
        <property type="protein sequence ID" value="SPAL_0000818850.1"/>
        <property type="gene ID" value="SPAL_0000818850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000818850.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7762" checksum="645BFF091A33D4A9" modified="2015-12-09" version="1">MYRRCVKYKNRCDGFRATYEEGDSIKLMILVRNLNEDKGTGPRKQKTTTKNPKGVKEKPGRRSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRD4</accession>
    <name>A0A0N5BRD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000843500.1">
        <property type="protein sequence ID" value="SPAL_0000843500.1"/>
        <property type="gene ID" value="SPAL_0000843500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895033" evidence="1">
        <location>
            <begin position="19"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000843500.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35856" checksum="6E5A91D6F673E8D3" modified="2015-12-09" version="1">MLVKLLPLLLIIFQATKSDSGKVTFGKNTCGFYKVNNDEELTFEFDKLEEYKTEQKGYINLKFDKIRILHLSLDGINDGASPCGLELNRYDDGGYKISYSAGYYQGNNFDFLLPLWCKIEQYEFGLVFFDRKKGADDLNNVNEVHTVEHAVLITIKSSNNKMLLGTRPHHKVNIILGLCPYINWVNKKRWIEFIPEDHIKDNGFFEEENGYAHIVVPFYKKNHNAEEFICGKLKQPTLPDLLIGFKLKEDDKNIDIAGEINPLNEEIKCQSSDNPQHHYHFGYLETDTNYISERIMDAMEIRNKDSKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS61</accession>
    <name>A0A0N5BS61_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="WBParaSite" id="SPAL_0000870700.1">
        <property type="protein sequence ID" value="SPAL_0000870700.1"/>
        <property type="gene ID" value="SPAL_0000870700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000870700.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36847" checksum="5843D8EB59A18C41" modified="2015-12-09" version="1">XWFVHNFGEAVFYFLKDKMTLQSEFDEKFEVGFYDSDNIIGDSSFLILNSNPFLDIPGPKTPKMVEVSGIGIKDPKPLDEYWNKILSLRNKTVLVSFGSFAKAIHMPDEMKNGLLETIRKLNDITFIWKYEEPEDGTGKDIENLIISKWLPQSDLLNDERLSLFVTHGGMGSTTELSFRGVPAIAIPILGDQMRNSKLIERQKCGIVMNKFELADSSKLIKNIKTILDDDTYKNNVKMVSRRLNKRPIGSKSLLIEHIEFAAEFGRLDMLDLASRNMNMIEYYNLDIIFLVIFGLFILLTLILYLIFKVVKKLFKPKAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTQ5</accession>
    <name>A0A0N5BTQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BTQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000923300.1">
        <property type="protein sequence ID" value="SPAL_0000923300.1"/>
        <property type="gene ID" value="SPAL_0000923300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="82"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="842"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1385"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000923300.1"/>
        </source>
    </evidence>
    <sequence length="1484" mass="173892" checksum="FDC11C8D31A09F06" modified="2015-12-09" version="1">MSNTDRNIIKSLLTVPEKLMKEELNSNNYCDKVWILDLPYKLCTLISQIDSNEVVVGFKDNNGIFKKKNVKKQLTQSVSSNHYVDDMCNLSELNEASVIACLKARYINANLIHTYSGLFCVFINPWTSSVSKIYTKDVKDFYKNEFKVEKILPPHIYYVAMSAYDGILSGNKNQSILITGESGAGKTENTKKIIEYIIEASDSSSSKCNKMQNDLINSGIVLEAFANAQTIHNCNSSRVGKFIKLDFDKNGKLNNAKINCYLLEKSRVVFQNLGDRNFHIFYQLLSDGVDKKRKMSLGLKKPPNEYAFLSHGKIKNDANLNDKEDAQSTINALLMLNFTEEDISQIFEVLSIILLMGEIKFGERKGLDISFVESMEYVKEVCRLSQIDSSKFVDALTQPTIKIGDKLIRKNQNLKKTLSSVLGLSKLIYDKLFNWVVDRCNEILLNNDSNNYSSSFIGVLDMAGFEIMNINSFEQFCINYTNERLQQFFNHFMFIKEQSEYLNEQIEWNEINFGVDLQPSIEMIEAPMGLLTLLQEECVVPNGNDISMLEKLTKTLDGEIFQKARQSVKNNNNSHFTIKHYAGIVGYNIEGWVEKNRDTVDNNVLEIMGTSNHSLLKIFFKNINNANNNTNKNSRTTTTVTSLYRESLHNLIEVLHSTNANFIRCIVPNYEKRAFLMNETLVLNQLRCNGVLEGIRICQRGYPNRMSFNDFINRYKCLLNYNSKEIQNSLRRQVGSKNRDAAVILCNYIPIDKEGYQIGKTKIFLKIGVVSQLENLRKKYLFDCISNFQGICRWFIEQKILKCKYNKWDAILTIQNNVKQYIYTNQWDWWKIFLKVKQIIPIKQNEKKIVDLINQNKQLEKELEEMKILLSEIEKEMELLKRELSILQKDLETKDDTYNELKIEFTNSEKLLCFMEKRFDEQQSTLSKMQSVLKQNERSLEKLKQEKELLEKEICQLKESYHTEQTLRQNFESEYEEYYNKYETLEKKHSQLLENSKNYIECLHSMEAKLDEQKDLSQKQNNKIVDLQNTIVELNDNINKLDSILNSERHLKRKIEDLKDDMEEKLEDLRDKLERSKGREETLKNQCIEKDRKIEKLENKIDQKSEYMDECINELKKMHKETQQEMKNQLDEYRRKCSKLEQDNRTLKIRVADVDDINEKSIIEDTDSYSSYKSNSRLGSRQPSLQSISYQSSTSNMTSSRYSTRSSLLRRRETEPDIFMAASMVSNENLSTYGSLNRSPSFNSSRYTSNDMGKEKKICNLEKQIQNLNQENQLAKRELEVYKTNLVDMERRNSSLKNQINAMTIENNNLNNKIERQEDEILMYEERLKKYQKEANIWKQKYEEMVDESRKELLMHRKKSEEKLKEICFEYSKKLHSYSTSDRNKIKIQEELDETKALLDSTKAQLYEVKKHSKSQSILGDNWENKYRSCMTEIESLRDENASLKNKVRRQYKEIELLTQQNEIKEECAMFEKKVDSFQERVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU29</accession>
    <name>A0A0N5BU29_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU29"/>
    <dbReference type="STRING" id="174720.A0A0N5BU29"/>
    <dbReference type="WBParaSite" id="SPAL_0000935200.1">
        <property type="protein sequence ID" value="SPAL_0000935200.1"/>
        <property type="gene ID" value="SPAL_0000935200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000935200.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46636" checksum="208AFEDCE51C1027" modified="2015-12-09" version="1">MLRAQVYDTGNDALTDKLKEKFSNVFSETLGKLDVEPVDDLELIKELPKIVKYSYNPETNDLIKNEVDKMFEQGILVLDNDVEYISNFTLARKKNGNVRPCMDLRRLNSAVKARVTILPEFNDIIRKIAGKSSYFSLDFSNSFLQIPISKRMQKYLAVFTYRGIAKFTRLPFGYINSTYIWNNTLENILGPIYSLNIVSYVDDVLGFADSHEELWNLASRILSSIEKHGGKLNVEKSKFFCSEITYLAHDWGCFGYRPTLTATKRLVEYPRPKNRTETRRFLGMIAFYRRHVKNLYLDAGPIINLVKKSSEFTWTTQCEESFNLLKHRLTSREILSSPRFGDLFILFVDGSQHGAGSMLMQYKSKEHEVADKGKYEFKDMNLIAYFSKRFQKGKLAKAAFRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUC1</accession>
    <name>A0A0N5BUC1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUC1"/>
    <dbReference type="STRING" id="174720.A0A0N5BUC1"/>
    <dbReference type="WBParaSite" id="SPAL_0000944200.1">
        <property type="protein sequence ID" value="SPAL_0000944200.1"/>
        <property type="gene ID" value="SPAL_0000944200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000944200.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18592" checksum="EBA34735EB8FE562" modified="2015-12-09" version="1">MTLIPFLKQIEISHNTDIFIGIHGSGLTLKQIEISHNTDIFIGIHGSGLTHLLFLPDWAAVFEIYNCDDPNCYSDLSKLRGVKYFTWPKHLINEGIKPVFAKQPKDIPHKKFQNYNIDEEIFRNEFIKIKEYVRRHPLFVEGQRKLRRMSILKQDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUD0</accession>
    <name>A0A0N5BUD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUD0"/>
    <dbReference type="STRING" id="174720.A0A0N5BUD0"/>
    <dbReference type="WBParaSite" id="SPAL_0000945100.1">
        <property type="protein sequence ID" value="SPAL_0000945100.1"/>
        <property type="gene ID" value="SPAL_0000945100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005277">
        <property type="term" value="F:acetylcholine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF13">
        <property type="entry name" value="VESICULAR ACETYLCHOLINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="34"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000945100.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="61427" checksum="5A86867D6E048599" modified="2015-12-09" version="1">MGGFNIPILNRDTDWVKEWIERTTKPIEVQKKLVLVVVSIALLLDNMLYMVIVPIIPKYLRDIHAYEETYEDYTNETRTLQNGSILVLQSGGHVDYLNEEIELGWLFASKALLQIFVNPLSGFIIDRIGYEIPMIIGLVVMFSSTAIFALGRSYGVLFFARSLQGFGSAFADTSGLAMIADRFTEESERSAALGIALAFISFGCLVAPPFGSILYSMAGKPVPFLILALVCLIDGFLVFMVIQPKQRIVDTNGIIKSEEKKNGTPMWRLFMDPFIAVCSGALIMANISLAFLEPTITNWITESMPDTPDWMMGIIWLPAFFPHVLGVYVTVQILKCYPHSSWILAAIGLAMEGISCAVVPFMTSIWELIIPLSTICFGIALIDTSLLPMLGYLVDTRHVSVYGSVYAIADISYSLAYAFGPIIAGSIVHNVGFLALNILICVLNVGFTPVVFMLRKVYNYESINGNGQEVHKLMNVEKPLIPERPSPPNSNNQGKFTGSYQYNDGWDEGYGGIGSNKYSDKMDNLTSDGFQLQQQQSNQHSYSNTNDPFNVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUR6</accession>
    <name>A0A0N5BUR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000958500.1">
        <property type="protein sequence ID" value="SPAL_0000958500.1"/>
        <property type="gene ID" value="SPAL_0000958500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894885" evidence="1">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000958500.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45247" checksum="7DEF998136CA6F1E" modified="2015-12-09" version="1">MKQLFSISFLVLLYLIQSTIEAKSSRYKKKPPTKKPSTQRKLPSYVQCYKPIKYHFEITKHDRFYVEGFIDDINDKTFLKFHEENNLIEGVGINFFSNNKEDKVELSYDDKKPTVVNLTKETYDTIENIQSETFLKFTKEKYPIRNVGINFYSNNKEDKVELSYDDKKPTVVNLTKETYGYRHLVGYYLGYALGLIPELARKDRDSDFYPYYENQISKYNDFSFNDYKRLNLLYCKDICKKSKTCGNYGYYGNNCDSCECFYPFHGKDCTLYHERHSECGKDITIKAYSKAKEKKLKNISLGECFYIIKANNPKKKVKLTIKRFKGVPGRYKLEIKYRKDKGAEHLKINGDVTWFKFPPLSSSVIINFVSYSPGNELELKYQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV23</accession>
    <name>A0A0N5BV23_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Dishevelled</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV23"/>
    <dbReference type="STRING" id="174720.A0A0N5BV23"/>
    <dbReference type="WBParaSite" id="SPAL_0000969100.1">
        <property type="protein sequence ID" value="SPAL_0000969100.1"/>
        <property type="gene ID" value="SPAL_0000969100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000203">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="12">
        <location>
            <begin position="86"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="11">
        <location>
            <begin position="537"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000969100.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="83365" checksum="EBCB0A0E8EBB00DB" modified="2015-12-09" version="1">MAQAGSSHDDSSQITQPTSLASSITSSSDQEDANTVIEKLSERMASMNQESSGAFSDGDGLSDISMGNIPVSGTLKQNAGSGSQASLVTKVYYHIDDDQTPFLSEIPVPPDRCTLADFKRVLNKSNYKFFIKLVDPEINMEVKRELKDDNELIAKAETNNILYLLTSEGSTVSEVTSHNSRPLKSIHNVPAPAPNGGIFGINSIDNVYKQARHAFDNSMMTTDSESFISSIRPVDDYKHSYNNKNNRLLMGYGRGVRRNHFDDTESEFRALSDDESRVSTSTDITSVSRQHLYRRRKNRKKYRQPSRASSFTSITESSMCLDVITVTLNIDTVNFLGISIVGQSSARGDNGIYVANVMKGGAVALDGRIEPGDMILQVNDISFENFTNDQAVDVLRGAVARKGPIKLTVAKSFDSGAKNCINKPNIREEPVRPIDTEAWIQHTNAMCELMKKGVGMPSILEGSEGAPTPVPGQRGPYHNVVVNNGRQSGSLATSNDSDGTPSTVIGMTANQHHIPQQPLRLSVGLDHRQIIRAMAMPNSGLDIKDRTWLKIPIPMCFLGSDLVDWLVEHVDGIRDRKEGKKFASELLKEKLISHVVNKNNFTEQCYYVFANSQDLLNDGGYLPPPPPGITNMGTLSQNGQWTSNHHGPPSIISGYASMPISPFPGQNMIIPPRVPADLHSQASGTSNDGSSSSEHRRVKQSKVILPPAPSLNSVPAHYASTGLLLKNGVPSRIDQMPSDLSGSRQSFRIAMNNPYEFFIDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV97</accession>
    <name>A0A0N5BV97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV97"/>
    <dbReference type="WBParaSite" id="SPAL_0000976200.1">
        <property type="protein sequence ID" value="SPAL_0000976200.1"/>
        <property type="gene ID" value="SPAL_0000976200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000976200.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23714" checksum="4B647C9169839731" modified="2015-12-09" version="1">MTIQELITPSNSNKRLPYNLECGTLKSIGSRVKYNNNNNKQSIEVGKNFKNYYYYCSKAHLVMDTKISEDAIKTLPKTETEKGFYFKATNDAYFGKHLLSNNETLQRSNANGRNLYYNTNRNCTTSTDDYYSYQRSETLSTTPNSSNESSLDINTNLSESNTTNKVFCMYIKSFVIQDYTDAVKIFHYNKRMIAKNLAKSYKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWB6</accession>
    <name>A0A0N5BWB6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWB6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001011500.1">
        <property type="protein sequence ID" value="SPAL_0001011500.1"/>
        <property type="gene ID" value="SPAL_0001011500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001011500.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30197" checksum="559680423F8C55BB" modified="2015-12-09" version="1">MLRNVLKIISGNKQVRYCTLVRGSASNTPNTEKPLPPSFYKIDETKRDKLANFGRYIAQCLPKFVEQVQFAAGDELEILIHPSGVIPVMTFLKGHHSAQFTNLSFVTAVDVPTRKNRFEIVYQFLSIRFNARIRVRTYTDEIAPVESITPVFKGAEWYEREIYDMFGVWFNNHPDLRRLLTDYGFEGHPFRKDFPLSGYNEVRYDPELKRIVYEPTELSQEFRKFDLDTPWETFPKFKDESIAAGYQIVETGGTAAEDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWJ3</accession>
    <name>A0A0N5BWJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BWJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001018700.1">
        <property type="protein sequence ID" value="SPAL_0001018700.1"/>
        <property type="gene ID" value="SPAL_0001018700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000216">
        <property type="entry name" value="S-adenosylmethionine-dependent methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001018700.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31517" checksum="CEB795A4E554BA25" modified="2015-12-09" version="1">MSKPELSGPPELYYNEVEAKRYDCNSHICQIQRDMAQRAIDLLELPDSISGIILDIGCGSGMSGEVITENGHDWIGIDISPSMLKIASQIRDVEGDLIERDMGSGLPFKAGCFDGAISISAIQWLCHSNSNDQKPRKRLLRFFQSLYGCMARGSKAVFQYYPESDAQANLIKGAAIKAGFSGGTIVDFPECQRRKKYYLVLNTGGVQNLPKALNENVEVEDEVDQCEVIESRSFNLHGNRKRKAPKGSKDYIIAKKERMRKQGKDVRHDSKYTGRKRKVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYW7</accession>
    <name>A0A0N5BYW7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYW7"/>
    <dbReference type="WBParaSite" id="SPAL_0001096600.1">
        <property type="protein sequence ID" value="SPAL_0001096600.1"/>
        <property type="gene ID" value="SPAL_0001096600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001096600.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21377" checksum="848A22F3DD8727F9" modified="2015-12-09" version="1">MNPNNSETFRRFNVVESTYYPDSKQVEPAPIESIKEKETLGGVATENENTQKRGVKFDEENIFETKAPVFSTYSYDQNETDPNFFKKKLQSYYYEAQPLKEIGSSTENGENSSTNSEDKEEIIRDFLKAKALYMQAYERMRLAGIDEGMLDIFGEADNVETPSMPNFVSSKCDVSAKQSTYVGYMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ06</accession>
    <name>A0A0N5BZ06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ06"/>
    <dbReference type="WBParaSite" id="SPAL_0001100200.1">
        <property type="protein sequence ID" value="SPAL_0001100200.1"/>
        <property type="gene ID" value="SPAL_0001100200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001100200.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9706" checksum="E51900EBC860E1D2" modified="2015-12-09" version="1">MTEVKENNPTYSLEVVYQCAMPFEYYEYSRKNYSTQSSQTLVKDVEGIVITDNDVTDVDELNDVIPDKWLHITEDDTDDIEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZJ3</accession>
    <name>A0A0N5BZJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BZJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001118300.1">
        <property type="protein sequence ID" value="SPAL_0001118300.1"/>
        <property type="gene ID" value="SPAL_0001118300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001118300.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22387" checksum="AC09D63DB8BA361D" modified="2015-12-09" version="1">MDSREEQSFDDPSNLYKVLGVQRNADDDTIKKAYRKLALKHHPDRHHGSDSTYHAEKFQYINTAHKILSDKGKRRIYDAYGMKGVQFWEGHNADTLPNFIFKKWFKPVFYVAFLLSCCCFFCCCGCLCCCGFCCNFCCGKYAPKDPLGEDNDYDFERNNEEVNTQRETVSETVSVNEAETIDKRQKKDDESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZS2</accession>
    <name>A0A0N5BZS2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BZS2"/>
    <dbReference type="WBParaSite" id="SPAL_0001126200.1">
        <property type="protein sequence ID" value="SPAL_0001126200.1"/>
        <property type="gene ID" value="SPAL_0001126200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1191"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001126200.1"/>
        </source>
    </evidence>
    <sequence length="1275" mass="146159" checksum="1E800CCB8D300854" modified="2015-12-09" version="1">XLYPYFGSLRSSMDTIRGSKKDVDGVVPLTHYLTKGRIDLDVTTVKCFFQRNMKAIIRRVPSEREREDNRAELKDIFSMLVESPTGNALSQIYEANKTKYSRAKFESVVNITLSDCLMMLANQTDHNALRNMRQESGESIMHFNNRFHLKMIEIYPEYNGRVTEEFSGVEAIFSPTEIRTRTQIFNDYVSAIKKNIADKIPYVDGPSKCLRYAMNKAIGIEANLRDYEERTKERVNREPTNKGFNWNGNRNQRRAAFSYQVTTNQNPPLVCYNCDEKGHGIKHCKRPMAQCSFCNGRGHLLKYCWKKKNQQGNNSGRSFGWKQNLHAMTIVIAIIMGTLMPQTECAVVTRWFQPLYVGDFMNETTSPTCTPSYTPMILHNEQLFTLTAPYEMIPANKGNYKPCPCDTSRKGFLLPGERCISFSYLNVDDKEAKLKFSYGVFDKILKREDGDRLQWAVLSQYMLEKRRGDKLMKLDTVTKQLVERLTNKINDAQEAEELEKEVQKALKGFAAEILAARQKQQQEEKQRKEEAVKLAKQQVALKNQRDQEERQRNELPEDTIIQDKGSTVSGSSITTPRENTEIPQSIDVSTIFRHYSKPEVTKSTPTEASFDETLLQLQQVNEVIENTFINKETPRRNTIIGDTQYMTMGSYQTPLTSRKATRILINTDQPPKPKPIVNSNNEQTLANLMEALSQKDESEYITFDPQVTSTVLKPKRFQINDDPISEKITKFKDSVKKIADMTQNLKETDLPSFKAEVETAIRNIDGMDVAKVFTLTLMAFCGVYIKRKGWNYVMTSILTRLKQTPDGRTALNPEDGTRRAWEQSRLDNSVLNTNGSAKSNTKKETGINRKGSTVTLCDEDEAIAKLLETRGFSFAFKVITNNGQTENPIVVLKIQGMLMKTYVDDGSELSLISKNRWLQIGQPDLEKSDVFAKNTNGDIPIVGKLRLLVEIPDRKKIEETFYVVENLTTEVLVGRSFMKNFKSYRHDYNEKNIYFGSHKLPIWFNSNDSRLVLKTNTEKVIQPGKDCLLYLKANKHSSIPLCIQPIKGVNQIKNNETQVQIWNTGTKAVKLTRNTPICLAVQLQPDEIFKAEDEVIAEEAEWEAELPDKRLETPLTNEELMQITDIPIEIQPLIRRYKTIFYEYQHDPGRYNGPIQHQILLKEDAKPKQHTLRKYRQEHVDAMMEIVKDLEANNQIGKSKSAWASPVVIVKKKSGELRKVVDYRQVNLLTKPEVSVLPLIEDMLEKIAGKETYTTIDLAAGFFQIPLEEKSREVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0P0</accession>
    <name>A0A0N5C0P0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0P0"/>
    <dbReference type="STRING" id="174720.A0A0N5C0P0"/>
    <dbReference type="WBParaSite" id="SPAL_0001156800.1">
        <property type="protein sequence ID" value="SPAL_0001156800.1"/>
        <property type="gene ID" value="SPAL_0001156800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="1">
        <location>
            <begin position="885"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001156800.1"/>
        </source>
    </evidence>
    <sequence length="944" mass="109279" checksum="AE34783D400B33D8" modified="2015-12-09" version="1">MIKASSRLSLLQYGIKLSDLTWYTISINANDYIMCLVKEEKSKSVILINLNSKEKIIYETSADSIKMNCFKNILALKNNSTVQVIGIGEKKNIIALNMPFEVEYWNWVGENILAFICKDNIYYFDIYKSNRPFISIARNDILKGYIIVDHDYNEATNYSFIVGLKQDINIVYGKILLTNQKITQYFDGTAGCFFKYKRTDLSSFDTFFAYINKNTTGCYIKILQLNNDVNKNIIKEICQINVSFSLIDLKSSDIPKALYFCEILGIFYIVTREAKVIVYHYDKRKEIGRKELTRKLVITSYFNRKNNAIMVFINDGYLYSFQLENVLPFLVSCRDVDYKTISNVFRNSLNLNPPSSIESVELKFEKLIDSKNYIDAGRVAGNDRSDKLRNINVMKRLLSFKSIDNVSECFEIYMKCLMNRSSLNHQETQLWIQYLICTENKFLIDDCIKKEKIEFTDDIGNDLLPYYPDLAIKVFANAGSFMTIVEYLLYINDENELKKFMTNYNLNSMFMDMFNSLLQSNPESALKFTFFLIDQYSESSKFELLDIITNTLVQNSYFDQAVQCLLGNLKNDSQRESNLQSKLIVLCLKYYPTIAENIFKSQKYTFYDKAKIANICKRMGLPHLALWNVEKIDEICDLLQQIKYKDDEIFDYLSHAPSEIIISCIKRLAEGKESYMVAEIIVNRYYQMTGDERFYKLIGISKNTEPTYGSDLEPKSITNNDYCEKLYPPLGKDCFNNNSTSISDQIRHIHLSKNNLPNFNSQTKPNFNGFSSNISTNSSPMVSHFSVDETLKNTSGKMNDDIKKIVNCDNDRLNGTKDYCNNKNNTTKHEQNEEKESMNEIGKNNLTPNDNCLLKDEISIEVQDNCVEEKNINTIKPPISSPLPSNESLLNEIRNGIKLKKVPKEEINNRISTNNESKNDINFILKAGLESRRKYLLEDEDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C122</accession>
    <name>A0A0N5C122_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C122"/>
    <dbReference type="STRING" id="174720.A0A0N5C122"/>
    <dbReference type="WBParaSite" id="SPAL_0001170000.1">
        <property type="protein sequence ID" value="SPAL_0001170000.1"/>
        <property type="gene ID" value="SPAL_0001170000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001170000.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36993" checksum="FA0FBEC30570A334" modified="2015-12-09" version="1">MVIGVVEIIQLSYLIPSLILMMFVACILLHKILKQSKTFQNEFYPMVCYRTFNDILYNVCILFMLKFPSWLIMPQYYLDSVHIAPIYYVLAASTFCAIFVHSIFLSVIRYVAIYYPGKYTRISSSRTSIILCCLLFLISFGVGLPTLAFPSKYIYNNATNTVLPAYAVKSITYYNFGYAIVFYGSTVILSAIFNVANLIGLSKNNKKNKNKRSENVFAFYTLFTLFTTSLMEAYFCCRISGNFFGNQKLLAIANYSVIWIGDIGTLGHFYFFVFINSEIRATIKEIFCKVFGIKYAPSLVKTTEIIKSIYDSKSLRSKNINRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Z3</accession>
    <name>A0A0N5C1Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Z3"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0001201100.1">
        <property type="protein sequence ID" value="SPAL_0001201100.1"/>
        <property type="gene ID" value="SPAL_0001201100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001201100.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29880" checksum="369B74840C7E9B10" modified="2015-12-09" version="1">MWNFYVLNQEGEKEYAIVSNTVFNKTNKSYGHLQFFKRDLLFNIEKRILVNDTLLLGCTVFYFCGPKNTVSTSTNSDISEHFITLLNDFNNLFESSKFADCAIKVGHSEINAHKCILASRSDVFDSLLIDKHHEFEPNIIEINDFSLEAVKEMVKYLYTGKLPNIDEMALEMLAIGDNFKLKQLKLAAEESLIRSLNIDNVCDYIVQSGLYSTEILQEWCLRFISLNPKIVENSVEWKKVIADHPSLVPKLFILFANVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2E8</accession>
    <name>A0A0N5C2E8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetochore protein SPC25</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2E8"/>
    <dbReference type="STRING" id="174720.A0A0N5C2E8"/>
    <dbReference type="WBParaSite" id="SPAL_0001215800.1">
        <property type="protein sequence ID" value="SPAL_0001215800.1"/>
        <property type="gene ID" value="SPAL_0001215800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001215800.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40323" checksum="036B2E305BE333B2" modified="2015-12-09" version="1">MKNDINSEDKVCNDDSCPKEEVVVTKLSYSKSQWYQLRELARSIKPAQEATDELRKQIEMRVKVRRKKFQIEGEIQCIKINIESLEEKIEAAKLRIKEMKVKREKVLKEKEAIENRITCFKKDISIIDQEYSEMKSTYILSRTRFTKLRTELFLRRRYMISELLTIYKFDIGVKYDSNSNSKFYHKPCSCGILDYIHGYQHLPTIKCISNHSEQEIVSAINELVHLLIIIGEILGFVYRFELTFHGLYSTVKSTVNNEIIRLTDVFSKTNRDKFIIGYGLINKNIAQLRSDVGLATRSERTLLNLQELLCFLASHDVNDGSGKERCAINDPFNIIAKSRPTKKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C362</accession>
    <name>A0A0N5C362_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C362"/>
    <dbReference type="STRING" id="174720.A0A0N5C362"/>
    <dbReference type="WBParaSite" id="SPAL_0001241700.1">
        <property type="protein sequence ID" value="SPAL_0001241700.1"/>
        <property type="gene ID" value="SPAL_0001241700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001241700.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23895" checksum="4563CB069D88366E" modified="2015-12-09" version="1">MEMKLPPFHGFNMEESSLFMDIEASVKGLEPTFPYQKDKRITVLNGYQFDFDNSARHHSPSSDDSEKLSAIYSSGFTLNRRVTKNCTHFFNQTNCKRGIFCLYMHDNSHQHLFHEICPDLMKGICTKLHQCKKSHTLFPHQMPVCSHYLNKKCNSKRCTYGFLHVKHSDDTKYCENFNNGLCINGDNCSYRHVYQEHLIKRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3E4</accession>
    <name>A0A0N5C3E4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inhibitor_I29 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3E4"/>
    <dbReference type="WBParaSite" id="SPAL_0001249500.1">
        <property type="protein sequence ID" value="SPAL_0001249500.1"/>
        <property type="gene ID" value="SPAL_0001249500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895284" evidence="1">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001249500.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12238" checksum="8A41B7A733F32CB8" modified="2015-12-09" version="1">MSFKLYLPIIVVLLVAFSLNCYAEYEDFFASYSQVVTTRKPTTSIDIEGLERVFPGFKDWWYEYMDVKREAPVFEDSLVDNLKKRSNIDKKLVPTHESNLRSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3S6</accession>
    <name>A0A0N5C3S6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3S6"/>
    <dbReference type="STRING" id="174720.A0A0N5C3S6"/>
    <dbReference type="WBParaSite" id="SPAL_0001261400.1">
        <property type="protein sequence ID" value="SPAL_0001261400.1"/>
        <property type="gene ID" value="SPAL_0001261400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="356"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="356"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001261400.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62133" checksum="BD9F7DBB9CEEE09C" modified="2015-12-09" version="1">MISLQRSPSTNSTTTGVSDNQHHSNGFDPHQLLQAAVASSQNLNVVNTSSSSQTNIGGPKLSPENLYLISNIQHRFNNHLNSLSTPEGQRFLGTLLMGSHMMPQAHGDLGNLPAPNTSPNSSLVPNNNLSNVVSSSTIPNTNLLTLELALNNNQSVHTLYQHNFCVWPGCNHPCESLAAFLTHLASTHRTDESNNTHIKNQIELIENLEHKITKEKQILHAMMNVIQLKSSLTDSIPPTFINSFPNQNGSSIRSSNNSINESPLISPQSQSNGDTSGNNDKTAFSITTQLNNLSNYPFGNGNSSSTNGILNSSNQAIKEESRQTSTPRKRVSDKSILPMQADIDRNREFYKNNDVRPPYTYASLIRQAILESKEGQLTLNEIYQWFTETFAFFRRNAATWKNAVRHNLSLHKCFTRIEQNVKGAVWTVDDQEFYKRRPQRTNGVGSGSVIKSKPSTPKPENSVSGSVLEMENIQKILNGSQTDLNFDDMNPLCILSNAALKINAMHDESPQKEIEKLVLSQNGNMPKVDVSRKVPKSRTPLPLISKTETNDDSRQVDNVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Y0</accession>
    <name>A0A0N5C3Y0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Y0"/>
    <dbReference type="STRING" id="174720.A0A0N5C3Y0"/>
    <dbReference type="WBParaSite" id="SPAL_0001266400.1">
        <property type="protein sequence ID" value="SPAL_0001266400.1"/>
        <property type="gene ID" value="SPAL_0001266400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001266400.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20016" checksum="7208D1EFFD969314" modified="2015-12-09" version="1">MNTTEDMKYSYQIKPFTSENSLEIRTMIKDLADYEKLGSQMILTDADVKNHINTGVLKGFVVVSTKNNNEKIMGMLLYYIAYSSWKGPYYFIEDIYVEPEYRKQNIGQKLFNEVIQLAKKNNIKKIAWHVLKWNTPAINFYKKMGAENLTEIEDRQVFNMDEKAIQNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C496</accession>
    <name>A0A0N5C496_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C496"/>
    <dbReference type="WBParaSite" id="SPAL_0001277800.1">
        <property type="protein sequence ID" value="SPAL_0001277800.1"/>
        <property type="gene ID" value="SPAL_0001277800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001277800.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21370" checksum="C6DADC489AAF84FE" modified="2015-12-09" version="1">MLFGCCYSDSYSSLSNVFIITIFDIFINSTCTGYFVKLYFYDKSNHIAALLAMIFSLCLTFSIISNILNFIGIVKKRSVLMIPKLVLSVTIISLVFLYGLSIGYLRFTNSILFITFLENQTNVELFIGKNKIKIGEIILFSCTLLFFIIQLYFYKIMYKCYKRILEHEVRLDVITKIFMLMPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4K4</accession>
    <name>A0A0N5C4K4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF104 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4K4"/>
    <dbReference type="WBParaSite" id="SPAL_0001288500.1">
        <property type="protein sequence ID" value="SPAL_0001288500.1"/>
        <property type="gene ID" value="SPAL_0001288500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001288500.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10496" checksum="A3365481CFBA574E" modified="2015-12-09" version="1">MNAVTKSGVILNIDNDRAEKLIKIHIDWPKLDLGTPREKTPDTVSGVLELFSRFERLEDNLVCSCKITRSLVDKVERISETYMKYFIFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4S1</accession>
    <name>A0A0N5C4S1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caenorhabditis elegans ly-6-related family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4S1"/>
    <dbReference type="STRING" id="174720.A0A0N5C4S1"/>
    <dbReference type="WBParaSite" id="SPAL_0001295200.1">
        <property type="protein sequence ID" value="SPAL_0001295200.1"/>
        <property type="gene ID" value="SPAL_0001295200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF1">
        <property type="entry name" value="RE49668P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001295200.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27126" checksum="FAB6A00538B19617" modified="2015-12-09" version="1">MNIISIVPKENKEVVKRKMINKNEVKLKSVVMVNKTFVRLFYFFVIINAFPILSVNCIGCFVCSSFNKSNPLCEDSFNSTLVLSKSFYQFQHPINITKNTRHHSKFSGPIVDDINSGGNNEYDGKIANYHQHCWAFKKNRQGLFPADHCIKISGVRSDDPSISMIIRTCALDSGTLTSDTEIVRISHCGHFKYSGKQYSGCVSSCETDGCNIGSSIKNSSLMTLYLTIFFGLVLYSFTYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4Y3</accession>
    <name>A0A0N5C4Y3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4Y3"/>
    <dbReference type="WBParaSite" id="SPAL_0001301100.1">
        <property type="protein sequence ID" value="SPAL_0001301100.1"/>
        <property type="gene ID" value="SPAL_0001301100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001301100.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35399" checksum="1501972617818D89" modified="2015-12-09" version="1">MAIVSSLILGYLKLHFYVLGDYVVLFLLPLSRPPSNDFIHTSLMGFSIFLIYFNITIPTGLIAARFYIVCTKSGFKKNSVIKVLGFCIILTLLQAISITFPFNKHVSSDIISNAIKKYDIESYMLTESTVALGLEVTDSKFISLVIFVPIYFTVNYLLIIYFVRKYKVYIKRHKDLISRQTQKINKEFMTILVVQTFTPVCLTGGPILVIIILFMIQKIYNISFFLNNIIHLISFIPSVNGFLFAILLPSNRKLILSTLNKIADTFMCRKSNQINNIRPSNVFSKKSTKISDSKTNSKQKRTHQQNSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C506</accession>
    <name>A0A0N5C506_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C506"/>
    <dbReference type="STRING" id="174720.A0A0N5C506"/>
    <dbReference type="WBParaSite" id="SPAL_0001303300.1">
        <property type="protein sequence ID" value="SPAL_0001303300.1"/>
        <property type="gene ID" value="SPAL_0001303300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048413">
        <property type="entry name" value="Htt_C-HEAT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001303300.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="65051" checksum="FDEAEBABBCBB14E2" modified="2015-12-09" version="1">MNILIECDDIELKKLEVNVKLAFNITANCFNTFKELDERNELSEPERKAIKSLLRCSVMYEFSLIPTSSQICNFEPKVTLTKDKILFKSISIHMLNSIDVVTDFSSRISWLGWKDRRQFEDFWMSLFGVLSSTPCGEELEKGDKEVIQEQLASSTVAIDALTNNLLQSFLFPKQGDTISSKYPVRLPILNVEKEEYTFSKQCNYIVDILRNKTFNPLDDDMYVEKYDLCQVTLYHIWVVTKVLEKTGIKNEINEINLNDEVNMMLPKSVSSYMINMTDDLDTNSSLKALLDNFSHWFSKGVQNMPLNLLTATTRSIVLLSDLFDDVSTYRSIYIQLKPLFETEEYKRTPIGGYILYYLLKYFSIVGIETFDEEQSESETIHFITSIVEKEIQSTCLFTKYCIYSGTIFLCQSYTTDKLASLIELISENLYKEVTNVMFNKLPDFYQDRIFQMIFSIQNLGLETKMLTEKNTVKIIMNTFNDKYISCNMLCKVTRLTMQLISYNNSLSKALMENLHLFISKIDKNMNIERVKCALSLFSKAICKVLDCTQYTTEIVIKLQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C561</accession>
    <name>A0A0N5C561_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inactivation-no-after-D protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C561"/>
    <dbReference type="WBParaSite" id="SPAL_0001309000.1">
        <property type="protein sequence ID" value="SPAL_0001309000.1"/>
        <property type="gene ID" value="SPAL_0001309000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06669">
        <property type="entry name" value="PDZ5_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06671">
        <property type="entry name" value="PDZ7_MUPP1-PD6_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="266"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="399"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="566"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="784"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1539"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1695"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1795"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="2001"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001309000.1"/>
        </source>
    </evidence>
    <sequence length="2078" mass="231630" checksum="69227E1333F07F92" modified="2015-12-09" version="1">MSSQQVATLLRQQNEVVQLVVGRSISCADAADTLKNESNIEQSPDIWTMPTKSVIFGSSLENEINNRLALVNKYNNNKIDNNLYPNTSKILLSTTTSDDSPSSSHLMVDEKNNSQTTNVGNHDITVIAEEDQLDINKTLHNQSSSLQLKNDSTSNNKEKNLDNSSPEERMNIIENKNDVNHPTDGEYKSKNDDDNKIDAVDNTETFSCQKLKLNTGEKKTLGGKSISKLLGDSDVKANTISKKLPSKVMKYFHRDQWVEGQYEEIEVEIERNPILGLGITVAGYVHREEEINGVFVKSLVKDSSAAISKKIKVHDLIASVKGVDCQNLSHAESVKLLVNSGPIVKLKLIRFSSESPQAKCLKMLQEQENNAKMVDIQANLIKAKNYWQERLGSDYEILTVTLIPDKYDDGGLGISIEGTVDVVDGNQLCPHHYIECLRKDGPAAKSGCLKTGDELLQLNDKILYGESHITVRRVISKARNEFKAIYLVVGRKATLFCDFDRTLSGCLPEAYNLLANYNDDQIVKAKSETQLLKFDENEFCSRPALIRSQSLQYTSGLAIWNCVPLVVTINKDSKGLGFSICDYHDSTHPNETFIVIRSLVPGGVAQADGRIVPGDRLMFVNSEDLSNCSLVRAVEILKSAPYGPVRLGIAKPVPVEYSNKIAHLPLISRSERLLAKSNSPRVNRRSYKKRICFDDSVKSNAISCDDINISDEQSKSFSTLQYYPYSNYYDRLFYAHYRLHSDDNRYSIGSSPCSSRSVSPCFSPSTRGSLYENEFYLPPILERTIKILKGPTPLGITFDTEVDKSINGCVVKHIYPKMAISRDGRIQVGDYIVRINSEKFRNVTSSQAKIMLKRLNYIGNQVTITYITSADAKLWKEKYGQESDNQIPMINRLSPKVFPKFYQSPFMNNNNTEMNNFCTTESNSVTSIISDSQFDISRSECQNKIPSVMSNSSLNKIISRMDDSEKNISNFKNYERPSFEGKMNTIDRVPNDNLITEKNYESMEDFSNELISKFGDSFVEDIINEIYEIMRSYERKEEEVTSPLSPKSNDFDLDYEISVLTKAYDKASHVIRELRRDYSLSYTGSGTSFNSLKEIISSSEVGETSPPINNIGSPTSQLSNLSIGVVPSNQTQSFTKNLSKNYIEGFPSNSIKNSNNIDKVNESGMMSKDEENCGKIKNILSNRNDILSSSIDKKCFSNREIPPDSKELGTFKGEDIEFIGKDRNIDDDNGSSTIKKDVRDDEKEPIISTTEKTIKNSIESYLINDKIMGRENKDSITNLSEVEDSGIKKEINFDKQVMVSSNELDDSDKSSDDCNKFNTTQLMRSRFWGPPRCVILNREANKSFGISIVGGRIEVSQRGNSQNSANTVSGIFIKSVLPDSPAGKSNALNMGDRVLSVNDVDLKDATHEYAVKVIKNAVNPVKFCVQSLQTFSPQNFKNRLNASMNKELILHNPPEGISTNDDVVFKQIGKPQLGQTNVVKGTKSIDSPKDNIASLKVREKDSAAFLEKTPTDREEEDIFGYTNDKVQRKYKDLPGKPIIIRIKNIPSGGIDLSLSENNEDNTKKSIFVMGITSPSSLSLENGDELLEINGHVLLQMNRKQAQEKIQQCMKDVELSLIILRCKESPVGEKYQNEESQKVNESSDRPLFNNSIDSQQAFIQSNTPNLICGENLLTKDSISGKMGERHVVIETGKETLIEIDKDGKGLGLSIVGGSDTVLGTVVIHEVYSDGAAAMDGRLKPGDQVLEVNDISLRGVSHDHAISLLRRTPSRVRLLIYRDVNLQHSLLDPTQIYNIFNVELTKKPGRGLGISIVGRKNEPGVYVSEIVCGGAAEQDGRLMQGDQILAVNNQDVTSLMQEELATLLKTCNGIVNLKIGRWKLTETTNRVHAATPPTYAVSKVNKNKQINDTKKDEKRSSENVGYFVNHNERNDVPPPCPQAKNNITNIPLNDENHQLSPILHKDLSPVTEEPSSCVEGKTTIEDGENKIIQLLPNVHEEGSEDLLIELKKIPDQQLGMGIGKRSRGILVTSLQPGSTAAEKLKVGDRLMAVNGQKVTDQLSAVTFVKASGERLFLQIARPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5G2</accession>
    <name>A0A0N5C5G2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5G2"/>
    <dbReference type="WBParaSite" id="SPAL_0001319000.1">
        <property type="protein sequence ID" value="SPAL_0001319000.1"/>
        <property type="gene ID" value="SPAL_0001319000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001319000.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14744" checksum="B1FBE52488D7DD5B" modified="2015-12-09" version="1">MSVLQTLIVNSCDTLKLLLSLLDKSVPIKVIIPLCTPHKCLCEKHIRATVSLDLPYRVAIFPDKRYNARVITENVAVQKNSFFNRMGTVYYKNSHQIKKFAECELPDDIAELEVERKKIRSSAVEGSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C640</accession>
    <name>A0A0N5C640_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GDNF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C640"/>
    <dbReference type="STRING" id="174720.A0A0N5C640"/>
    <dbReference type="WBParaSite" id="SPAL_0001341500.2">
        <property type="protein sequence ID" value="SPAL_0001341500.2"/>
        <property type="gene ID" value="SPAL_0001341500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="601"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="692"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001341500.2"/>
        </source>
    </evidence>
    <sequence length="1159" mass="134468" checksum="74F789FB7382B2E6" modified="2015-12-09" version="1">MCAYSMKEVRKFLNITNEFYCKCKNISKTRHICEGLKDFIFNHPCNKIIMYYDLINKNILPLTDPNLSTYTKNQIAKRRKKRSPTNYEIQELKIQLNNELRRINSLSTPIQPQVSCDYALNQICLRHIACHELWNIFRRSCIVDSQNNCRMTSLAHCWQSYEGISWTGLGNCTCYDKNSDCHWIRLQTNYNKCISEIHSRSMSNVLYDAKPFTTIPPNILYATTSAPLTTSMKRLNDHFKETKMSFNTTKYLETKKHSSDHFNNYNNKEQMFSTITPTKMPLQQPLYDYETFKYSPTSIKSIYNNTNYYDREHFHKTTDDYKNNNDQNIIPTNKESQILPPIYRNISKDYRISNSTVINEKKLLENFQSANYTLDNKKNVFKNDYSKGNTKQTEINKNYKNGLTNIRINGQPFIPPKHQNPIHFKLPPKDEEKKMTGSVYDSKNYQLYSKIHGTPSYDHLQSTSKSIYRNLTKELNQTINLSINDDSKILGYNNISQSLINDKQHQPLNVTEKQIIKDNYFKNIENKEFNITSYFKKTPILPVSEDSKNMKYKSSSNDMDNIEKMNLKEMNVFNNKSNRINVDYNNIITLLKSQPAKLSSCQEAFQLCSQDENCQWLFSSIQMKCKSGDGNGENNCNRQQCAKAIKNLATSPQRSIVEAMMFCQCAPNDKECETLQQWMYPPCLYDGSIPNCKEVISSCLKDRSCKHLSKSYFHSCAVSNGSCKPGTYQMNGCRQAVIKLRGSVIDTLCHCEDGDNKCWSHRIELIPLNPCLQKAKDDYAMKGLMPTKPSIIPHDIQLPLKQKNKVINETEKINLSGIINSSTSIYDSKKVVENKNLIEKINISSKNISNTLNITNKEDTEKIMYDNFTIPTDEYHTQEPPSTELGCRLRNFNGDWVEVFKGTIFRQYTDWYGRCSNWCECLGNNTQICKELPCLENDVCIHGSNIMNFGEKLYIEGRGACTCHMGNFICDTPRELDINFQPGLYILAGFSKQELQMFKENVPLEILEKSGLVSDEKMLAKDIASRLQYSLERIMPTGTMCRIIIIEEYLKDEIVILRLQWYGMNIYNKNDTEYGWHVGSLEKVCSPYVKQVARNFLLNMAERYQLVLSSVKQIRVVDLLNELPSVSSGTFLLKNYNVIILFYFPLISTFIKIYFFYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6E7</accession>
    <name>A0A0N5C6E7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6E7"/>
    <dbReference type="STRING" id="174720.A0A0N5C6E7"/>
    <dbReference type="WBParaSite" id="SPAL_0001351600.1">
        <property type="protein sequence ID" value="SPAL_0001351600.1"/>
        <property type="gene ID" value="SPAL_0001351600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001351600.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="24719" checksum="159BDDF8936A40C3" modified="2015-12-09" version="1">MVANDLNNSLEKVFLSDDTGKEMVREKRQARGPRNRQKQKKLTQRQRRFRARQRQEAQRARIRKQQRLRQIRQRQRMEKQRRLRRQRLQKQRLQRQAAERRRRERRKQEEKRRRERQKKRLSTTRRTTTTTTKTTTTTQATEAPTEGSDTGDQTYYDEEPQAESEYYEENPEDNGGEQPLEEEQYEYEDDAEGGADDAADETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6I0</accession>
    <name>A0A0N5C6I0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6I0"/>
    <dbReference type="WBParaSite" id="SPAL_0001354600.1">
        <property type="protein sequence ID" value="SPAL_0001354600.1"/>
        <property type="gene ID" value="SPAL_0001354600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001354600.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18883" checksum="3616D9CBAAAA054D" modified="2015-12-09" version="1">MGASKLVQKLDSISKNLSRSDHGRNKNVYDNTPTIDLRRGYCVDLKRSVKIFLETKLTDVGEVTLLQSLNGSIGALLYCDDMCYNNMMTAATKSGQLCHVGYRLLIPELEDKSKVGNLLSFSFIPTIDVQKDYRLYIMEVLKHFHNFVLTFKGKEFKLNVHLIMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Q7</accession>
    <name>A0A0N5C7Q7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Granulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Q7"/>
    <dbReference type="STRING" id="174720.A0A0N5C7Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0001396800.1">
        <property type="protein sequence ID" value="SPAL_0001396800.1"/>
        <property type="gene ID" value="SPAL_0001396800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00799">
        <property type="entry name" value="GRANULINS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895495" evidence="5">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001396800.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55460" checksum="3723B35E6D2D14B3" modified="2015-12-09" version="1">MIFLNRYTITTFFLLISLVYSENEICDDTRYICPTGDTCCKLGNSTYGCCPMPSAVCCSDHEHCCPHNTVCKEGRCYSENKKSISGFKLKLALLVKENDNEKNIYKNISKHTCDDKITECPDDNTCCQVKPYGYGCCPLPNAVCCSDREHCCPHNTTCINGMCRKNNDKFISAFKLKIYSNNKERFNKNYKNELSNICEDKKTECPDDATCCLLNSGEYGCCPFQDAVCCNDHLHCCPFGFKCNLKEESCEDNRTGKKIPLVKKISGRNITTEHNNDAENICPGNKYECPNHYSCCRQANGSYNCCPSTQKCNPVTGKCVNKGFVRGALKNKSVKAKKIYLKKAYNLKQGFIRCFGRNYCKQREICCRGYDGFSYCCPKSQGKCDPSGFGCYESGYEYDAETGKAVLKTEIGEFYSPIVNTTVALKKNLDNSTVCDDGTICEDNQTCCPYENEKEPLEYRCCPFKNGECCRNSCCASEYKCSSNGKCLKNNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7W1</accession>
    <name>A0A0N5C7W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001402300.1">
        <property type="protein sequence ID" value="SPAL_0001402300.1"/>
        <property type="gene ID" value="SPAL_0001402300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895505" evidence="1">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001402300.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="57512" checksum="3A257E294EA7837F" modified="2015-12-09" version="1">MNVFIFILYTCVLFSVSQGFIIEWWEKIFGRSKDNSSKPKHNDPNSRILYKFLDLDVKPCDNFYKFACGKWIKTMEKEYGNFGSFNHRTDTFDKFANGEKKYNDESKMLSTLVYLRDKCSQDLPNDKVYSCGNEIFEFGKYALSSVFLRRNIKNFEHNNGNLSVNQIYLNIKEQFILLIDEKEHLFDLDTRRYFKDKINHLKLATSFDDHHLSNVEHMENCYYNSIGINYNDHISTILANINNLKALSQNDDLTTCRGKIFQISKFMPLIVYGNGLYDPNQNLIAINSGLVNEPSYAWYFKYPLNYGYLGNIMAHEMLHGFDSNNYNRTLANKISDYKVSQMSMENYEKKASCFVDQYNKQIESKTNMYIDGSRTLAENIVDNGGLKVAHRAYMKFRERNNHKNSPVKDFEQFNDEQLFFISVGRNFCEHKNKYILEQLINGDNHTPSEIRTNMMLSNYQPFIDAFNCPVSSKMNREHKCELWKSQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C898</accession>
    <name>A0A0N5C898_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C898"/>
    <dbReference type="STRING" id="174720.A0A0N5C898"/>
    <dbReference type="WBParaSite" id="SPAL_0001415000.1">
        <property type="protein sequence ID" value="SPAL_0001415000.1"/>
        <property type="gene ID" value="SPAL_0001415000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001415000.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15626" checksum="5E46E25E03C417CE" modified="2015-12-09" version="1">MVSLKKLAEKFMMCRVPVMTTKRRNHGRNKKGRGHVKFVRCTNCGRCCPKDKAIKKYVVRNIVEAAAIRDIVDASVYDQYALPKLYHKLHYCVSCAIHSKVVRNRSREARRDRNPPPRFGQRTTFQKPVAPGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8D2</accession>
    <name>A0A0N5C8D2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA_mis_repair domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8D2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8D2"/>
    <dbReference type="WBParaSite" id="SPAL_0001418300.2">
        <property type="protein sequence ID" value="SPAL_0001418300.2"/>
        <property type="gene ID" value="SPAL_0001418300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="211"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001418300.2"/>
        </source>
    </evidence>
    <sequence length="792" mass="90377" checksum="8ECDF2753C4F5C9A" modified="2015-12-09" version="1">MGVIHRLPQELIDLIAAGEIIAKPFNAVKELVENSMDAGATEISIIIADGGLSSLQVQDNGCGIDKDDLKIVAERFTTSKLKSTDDFKKMQTYGFRGEALASISCISNLSITSRTKDSNVAFSATYVSGKLEGAVKPSTGKIGTLVTVKNLFDKLNVRKVSFKNSTDERNRISDVIVRYAIENPHIAFAFKSNSNKVSFRTTGNNNIRDCASVLLGPSIGNSLIEQNFSDKRLHFECKLVLTKPKPPRVSTYKKDMEGNKRIFHIFINKRLVECSSLQTAINYTFNCCGKVCSFISVSLKIDPDRVDVNIHPSKKDVIFLNSEQITQRICEYVKNYCRDEADATMELVDVSQKLSLYFGALECDRTKNNGSSMSQGICQSSQKDISNNSLMEVENSSKISESTDINYKTSHLEDKKNDQDKVQSISEDQKLHPHEPTAKKLRLTEDVNSDLQPSIMDFVTHDDNLKNTQLNMESFGATSNKQKQVNQLPPKKIYDHYKDRTNTVDRKIPEFFHKDNKDDFRRLSISQNIELISINDHTQVTELKDKPDVLNILLRKFNLNSLKILTNGVFQHTDEQLKEIFHRFTFVGFSKDLDYILIQHNTSLFRLKFEAENDDDLPYLEDLLKCYLLLTNTDVEDESVLTDIEEGIEFLMTQKEMLWDYFGILLETKNSKPYLSAIPFLLENYIPHYEALPGLVYNLIGGVDYSDELRCIHQMCCILSDFYIPKTKFCSKVEAENNIYCLNKRIEQWQEIVKEILIPLIPKFYPSKNLEANKAVYKVTDLLDVYKDFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA10</accession>
    <name>A0A0N5CA10_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 38</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA10"/>
    <dbReference type="WBParaSite" id="SPAL_0001473500.1">
        <property type="protein sequence ID" value="SPAL_0001473500.1"/>
        <property type="gene ID" value="SPAL_0001473500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05804">
        <property type="entry name" value="StaR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001473500.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52939" checksum="8D231FDC137E863A" modified="2015-12-09" version="1">MGEWCAKNLKDVQGWKEDGLNTTIVNNETAKLLDASIRQLVSLRDCDQLGGLVKTITNMLSNEPNAVLPRIFALAVDVLGTNKTWYVNEEFKDKIKKVINDTDKYGNEREKLHCNALEAMAVGYTRKALYYYECILGQYPNDLMAIKLSQQLYFFTGQPYEMTSSVSRIIQKWSKEHIMYSYLLGMQSFGYEECGNYRNAEKTAKEALSLRKEDTWATHALSHVYEMTGQYEKGIDNLNETSFYWRPCWILECHNLWHLALFYIESGKFEEAMTIYDQSIKPCLIKNNSILDACDASGLLQRLEFYNFNVGQKRWDELVSFVLPYTKGNMYPFNYPLMAIALGHSSNENHLKDFINLDIQHAPTCGETAFYVKEVSIPIVKGIDRYLKKDYTKCLDFMYPIRYSFINVGGSNAQRDIFTQIMLKAGVKSGTDSSKEKAKVIFEERRQLYNLKNAQYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA97</accession>
    <name>A0A0N5CA97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA97"/>
    <dbReference type="WBParaSite" id="SPAL_0001482000.1">
        <property type="protein sequence ID" value="SPAL_0001482000.1"/>
        <property type="gene ID" value="SPAL_0001482000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895652" evidence="2">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001482000.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12212" checksum="C49B1C8DA014454F" modified="2015-12-09" version="1">MKFLVFFLLSLNVLLTCQEQEYFLCNTCTNLFDDMRKILTYQDGIKTTNDMAVICHKIASKKGYFYSACKTLALHVVDIMNIKKVDLKDTTSFCSDLGLCPKNDSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAB7</accession>
    <name>A0A0N5CAB7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAB7"/>
    <dbReference type="STRING" id="174720.A0A0N5CAB7"/>
    <dbReference type="WBParaSite" id="SPAL_0001484000.1">
        <property type="protein sequence ID" value="SPAL_0001484000.1"/>
        <property type="gene ID" value="SPAL_0001484000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001484000.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="63812" checksum="D5B0891965D42C3D" modified="2015-12-09" version="1">MKLSHEVREELRRYDADKIDTFAKVTSILENKYDDKSQRDDTRKKSRNFQIDFRPNHTLESLKKLCQLLKRGYPDLSKKELLAQTIDTMMIRLEKKFRSLAERLREQKRDFENTSDLIHTVHGLLKDKTKYGYQRDVKDRNDSDVTCFNCKKKGHKKNQCKILRKKPSFGDKSDGKLIVRRIDICTGKGIIVSVSINQVNDLSAFFDPEQIKVGENQEWNVIGTGKTTLTLGNDFLKKTKGYEADYEKGTFKTIRGECVQLIRTQIGEEKELKNAIRRIAIVDEESAHLEAKFKDDHDYVFSKNEWDIEKCTVKAKEMCLVENKSFPKVVGYVNIPQKQSIINEFGKTVNFVSNARRRKKVIGYFLKRFKEWKKKSSALEIELRGIIMALNHYMDLLTGSRLTISCDHKPMSSFVKNSKCTKVIDILETINSFDIDIKYKNAASMKPADSLSRQYVRRIVLTENDKLITSRSDNGTLMKIFKSFHNNIGYLDYSRTISLLKLRINYDGIATNYINYLKSYEKCMAVNNKSYKNKVDMKIVTIKLPSEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAZ9</accession>
    <name>A0A0N5CAZ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAZ9"/>
    <dbReference type="STRING" id="174720.A0A0N5CAZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001506500.1">
        <property type="protein sequence ID" value="SPAL_0001506500.1"/>
        <property type="gene ID" value="SPAL_0001506500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001506500.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10859" checksum="5F9AF5C1E2727682" modified="2015-12-09" version="1">MATQLALFASIILPLFISWLGLYNQWIPEINRRLPVFFINSLGYIPFVVVGGLGMYALFSVAYGVATFNDCKEAQKELMDQVAEAKKELKKRKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD04</accession>
    <name>A0A0N5CD04_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nkap_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD04"/>
    <dbReference type="STRING" id="174720.A0A0N5CD04"/>
    <dbReference type="WBParaSite" id="SPAL_0001575200.1">
        <property type="protein sequence ID" value="SPAL_0001575200.1"/>
        <property type="gene ID" value="SPAL_0001575200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001575200.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30741" checksum="31A6F07766112B2C" modified="2015-12-09" version="1">MDKKDYNSKRSHSKEKSYRERKSRSHSSEKHHHHRKESKDGQHDYWEKRRREREKIMRKPRRSIWADSPTRSEIKEIEREHKKIKEINKKEMEEFDEQIKEVVDNAGNVDIDFTEKISSSNSLVNDNVSENKGDGDDVEVIGPVIPSEVSTKFTTTSGITNYGDNISRNEGAAFAAYISQGKRIPRRGEIGLTSNQILEYEKAGYVMSGSKSLKMEAVRIRKETQVMTAEEQALMKKHNIEAKKEEEKKIMEQFKLLIQKKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDB5</accession>
    <name>A0A0N5CDB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDB5"/>
    <dbReference type="WBParaSite" id="SPAL_0001586000.1">
        <property type="protein sequence ID" value="SPAL_0001586000.1"/>
        <property type="gene ID" value="SPAL_0001586000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001586000.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28035" checksum="2DBA07D5FC39C114" modified="2015-12-09" version="1">MNAEFASTIVNAISEQLRGFKEYCTQGNTLILTKLNAIEKDIKIIKEHIEKSSGEKTQNSEHVRIFSLPTTKDAMSANEEVLSECKTSHDNAFDEHFRHLKDERDKAFSDLDMYFDTAVGVKSGGKEMTSFTLSSNVLKDVECRLYVKSEDDGKPTEVGQVLCSLTVVTGGKILEIDDKGNSSKYKVRLNNKYMNEVSKKDGKKYIAIIFSEKSFDHIDGSRLKEFYLKFADKESGTDFYEKIKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDN2</accession>
    <name>A0A0N5CDN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDN2"/>
    <dbReference type="STRING" id="174720.A0A0N5CDN2"/>
    <dbReference type="WBParaSite" id="SPAL_0001597600.1">
        <property type="protein sequence ID" value="SPAL_0001597600.1"/>
        <property type="gene ID" value="SPAL_0001597600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001597600.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30422" checksum="3DF34B6CE404B3C6" modified="2015-12-09" version="1">MNECNIVLIKKPSSISNDISSFRPISILQTIFKIYTGTLLERIQDKIENCVSSSQAGFFRKRNTLNQILQFCTIIQTSREYKKDLYAIFIDFKKAFDSVNHSWLLYSLAINDFDEELVKRIEALYRSPKATFSTGINNSYTTIEVKSGIRQGDTLSPKLFILLLEIILKNAQHDLDDCFKNEESNLVKIMIDGTPTVSFKLEFADDIVIYTYDQKLTEKIAQVIEYHARKTGLELNKDKTKMMATQYKKKLDNPIYEVVSNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDU0</accession>
    <name>A0A0N5CDU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDU0"/>
    <dbReference type="WBParaSite" id="SPAL_0001603400.1">
        <property type="protein sequence ID" value="SPAL_0001603400.1"/>
        <property type="gene ID" value="SPAL_0001603400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001603400.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18892" checksum="A55F52E2413E00D5" modified="2015-12-09" version="1">MKHLNIIFILSIIFYISIISNCFKFTCVGKDYKAPCYIYMNPYGISFRYKVLKELYDFDYWIYYKVETMVKESCTRSKKLGDVNNYIRKKVPHSVILSICYRLGIYTKCRLNTILVLSPKLSNKRKCRDFIGMIDRHEHKGDIGLRMPQLRRQSLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE32</accession>
    <name>A0A0N5CE32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE32"/>
    <dbReference type="STRING" id="174720.A0A0N5CE32"/>
    <dbReference type="WBParaSite" id="SPAL_0001612200.1">
        <property type="protein sequence ID" value="SPAL_0001612200.1"/>
        <property type="gene ID" value="SPAL_0001612200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001612200.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9258" checksum="7EF18CE4A43DD26B" modified="2015-12-09" version="1">MCKGTQAALESNENFENEERRRPESTLNNDKLRKAVESNPRTTVKKLAKKLDISRRTDFCHFKWIEKTKKFGKWDLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEC8</accession>
    <name>A0A0N5CEC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEC8"/>
    <dbReference type="STRING" id="174720.A0A0N5CEC8"/>
    <dbReference type="WBParaSite" id="SPAL_0001621800.1">
        <property type="protein sequence ID" value="SPAL_0001621800.1"/>
        <property type="gene ID" value="SPAL_0001621800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001621800.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43378" checksum="441E58449913697B" modified="2015-12-09" version="1">MNREHERESDVPIDDSRDIHGNVNKFDYICSIENFSQRLERTGEPIESPTCVIGSEQESKWCLNIYPNGFNRVYKEYVSVFLKLLKPDKAQAKYRLSILNGEQKKKNARRSRKVYDFDVNGENDSWGYKDFVKKDFLLNELNSLLVNDKLTILCQVEIVNLESENFDNSVTSMNVTTPQSTLPLDYSKMFESQLFTDCIVKVEDTEIKVHKAVLANRSPVFHDVFNSMSKNLQTNVVEINNFRVEVVEKMLKYIYTDDISDIKNMASEILAIATEYGLNKLKDIAVRYLCRNLSIENICERLLLAETFSNEELKENCQKFIIGSPESLRRAKHVEEFIRNYPSLFKDFLFRVVQLLSTSSNNSSEEISNIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CED2</accession>
    <name>A0A0N5CED2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cirhin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CED2"/>
    <dbReference type="STRING" id="174720.A0A0N5CED2"/>
    <dbReference type="WBParaSite" id="SPAL_0001622200.1">
        <property type="protein sequence ID" value="SPAL_0001622200.1"/>
        <property type="gene ID" value="SPAL_0001622200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001622200.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="74069" checksum="AE7EC8B72764589B" modified="2015-12-09" version="1">MTKSSKRVGRSEIIVEQSNLYLSEGYTTSSLCINTSIYKLCAIRRLDNTEQSISVIEFWNVIEMPNMVLEQSIPLINVEIEACEWVGNYAVCAATNGMVYQVNPFTGVTTSCQICPSAIWCIKSMSDSKFLLGSDNGIVYLCILDREDNDKILIKSRINIDMETRILSIAYSSEVSIIGVGILDAIIFIKLNGNTEIKRYTVKLPKRDLTVEVLVWSLAFQGKTLVSGDSLGRTCLWNSKNGSLLKIISSHQGHVLALAVSGTDIFASGTDYRIQVISALTSQEKKFDYATKGQRIIHSNDVRALAAIDQWLVSGGAEHELYVSKKHEKTKTFGSINQTRVAKDCNKILFAYSTYVEIWLRGDTDFDESKKIGNNYTLMNIPKNVLRIDSPKKRFIVNAEISPNGKYISILTDKMTFVYKICLEEKKPVVQVLALPYKSNSIILEDDVVIWSNGNFSISKYNFNEKKEVSLAHVENSFCLTKLVKNTSGSLVVGRNNRNQLIVFGREKCEDVFSTLNVTHSITDFKFIKENVIVVSTSSSSHSLMLYNLDTLEQIGSSISYEALFGKDQNGFIDGLEYSAKNGKLVVVSENNWKIVSGLSQGSPVLESLNLQTVEKNSNKKCYIVPKWINDKHSENVLFLSYSSPRGMPSNVPTNISRYGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFF4</accession>
    <name>A0A0N5CFF4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFF4"/>
    <dbReference type="STRING" id="174720.A0A0N5CFF4"/>
    <dbReference type="WBParaSite" id="SPAL_0001659000.1">
        <property type="protein sequence ID" value="SPAL_0001659000.1"/>
        <property type="gene ID" value="SPAL_0001659000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="197"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="719"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase epsilon ,catalytic subunit A thumb" evidence="18">
        <location>
            <begin position="944"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001659000.1"/>
        </source>
    </evidence>
    <sequence length="1251" mass="145001" checksum="2130A59C9C4852B8" modified="2015-12-09" version="1">MDGSVEVGSRENDKNYVQRRERINFRNDIDAKYGYQIYTESRPKIAWLVNVQSSELIDENNKDIVACVDYYFLEESGERFKICYPYRPYFLLATVGGFEFGVASYLEKKYMEFIKVDIIEKENLDLKNHLSGVKSKYLKLSFPSVSELQRVKKDLMPIIEKNKRRIASENEYKSLLAKHLGNIDTHEIGEAVDKIIEIREYDVPYHMRVSIDNKIFVGLWYTVVGRDENRLPSLKRNYDIIEPAEPVVLAFDIETTKMPLKFPDSDFDQIMMISYMIDGLGYLIINRTVVSADIHNFEYTPKPEYPGEFTVFNEEDEKALLMRFFDHIIVSRPSIIVTYNGDFFDWPFVDARAKHYQLNMREIIGFSKDSQGEYKSDNCLHMDAFRWVQRDSYLPMGSQNLKACTKAKLGYEPVELDPELMVTMAIEKPQILANYSVSDAVATYYLYMKYVHPFIFALCTIIPLGGDDVLRKGSGTLCESLLMVEAFHNNIVFPNKLVDDERKITPDNRVIESETYVGGRVEALESGVFRADIKTRFCIVPEAIEMLKEQVKDTMKFALNVENGIDLDNVVDFEEVCKEVEGQLDKLRETPNLFEYPKVYHLDVGAMYPNIILTNRLQPPAIITEEDCMACVYNTPDAKCKRDMNWVWRGELMPCTRTEYDRIIQQLENESFGKPPVPFHELPKEERMKLEKKRVQDFCRRAYGKNHVTRTETRTTRVCEREHGFFVDTVKAFRDRRYEYKEQLKKAKGELAKTPSDDLNGIRAGQSRVVLYESLQMAHKCILNSFYGYAMRRGSRWFSMEMAGIVCHTGANIIQEARKLVEQIGRPLELDTDGIWCMLPSSLPENITFKLQGLKKDKVTISYAGSMLNALVKDKFTNHQYHVVKPDGDCEIKSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNFDGSLSELKGFELKRRGELNMIKLFQENVFKLFLKGKTLEECYKCVAKEADYWLDVLYSKGVDMSDKQLFDLISENRSMSRKLSEYEGQKSTSITTAKRMAQFLGDEMVRDAGLACKFIISQKPLDAPVAERAIPLAIFQTNRKTQARFLRQWTKDTAITEENVDIRNIIDWAYYIERVGNTMQKIITIPAALQGIPNPIPRLPHPEWLDNIKKEKQFQINQPKITSIFKKIPKPIKDIEVICTGENVDKENEGNCHRKRGRSIVIDNNVQVMENVPTSKKQKTIDERKTILKDGFKEWVGIKIKKSKSYYYTLFNLKNQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFV7</accession>
    <name>A0A0N5CFV7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFV7"/>
    <dbReference type="STRING" id="174720.A0A0N5CFV7"/>
    <dbReference type="WBParaSite" id="SPAL_0001673900.1">
        <property type="protein sequence ID" value="SPAL_0001673900.1"/>
        <property type="gene ID" value="SPAL_0001673900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001673900.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49605" checksum="3537254BF1DB30BC" modified="2015-12-09" version="1">MDSSGNSKKKWTDEERNALAEKMDKELDDFINNLAAQKKDNEKNAPKKEFNYDEWEKDISQHPAFMTKLPEDGNSEYNEYIEAIRALKYDVGDTPEEIILDAEQHKTNGNKHFKLKKYRWACEEYTNGIKLKPNDLELMSKLYGNRAAANYEIGNNRSCQRDCIWALRLDPTNFKCITRMTRSLLNVNKIYEARDWLEKNLEYLKTLDGIKPLPNNWDEDVLSLKEEIGKKVAIKQRDERKERLLMKKKLDENEKYLKAFKKRNLKFVYPTVDLDNVKGFDLESLEVNISQLSTKECVQFDSDSKTLLWPILYQYPEIALTDVMKSSSEETIFELLLETLSQNWLDETPWSIYKFGSIVITFECGKKRGYLFRVNIKEKLSEILSKEELFIKGGLPVFQIYTETYFNNNFIDKGKNYYQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG26</accession>
    <name>A0A0N5CG26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG26"/>
    <dbReference type="STRING" id="174720.A0A0N5CG26"/>
    <dbReference type="WBParaSite" id="SPAL_0001680500.1">
        <property type="protein sequence ID" value="SPAL_0001680500.1"/>
        <property type="gene ID" value="SPAL_0001680500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17301">
        <property type="entry name" value="PIPKc_PIP5KI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF101">
        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001680500.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62315" checksum="FEAA835BB699248F" modified="2015-12-09" version="1">MSGSIVEAKVKSSTTTFPVYEIAPTEDLSPTPNTLNASNNQFNESKEKQKLGHRRIDRQGEVSYKKVPTNALMGAVQLGITNSIGSLANKPERDILMSDFQEILSVAFPSEGSIQTPSHQYNDFRFKTYAPIAFRYFREMFNIKPADFLRSLCAQPLRELSNPGASGSVFYVSSDDKFIIKTVQYKEAEFLRELLPGYYMNICQNPKTFLPKFFGLFCYQSLGKNIRLLVMNNLLPQTITLHDKFDLKGSTYKRYASKAEKAKKSPTLKDLDFNEIYPDGILLDQAVYDSVVKILERDCLVLRSFQIMDYSLLLAVHNLDRATLEEFEGEMNDGHEGEGNYNSQDTISSHTSLIRLEKWKRIQAQFNSSLSSAEQGIPAMNSKGEHLLLFMGIIDILQRYKLIKKLEHTWKSILHDGDSISVHKPDFYKNRFQKYIFQTCFKRSESGPPTMKSSHKFRSLVQSYLAMRQSPITRSNRSIPTSSFAIDERDEDEIDSRKISIDHGPALYPSRSSLSHRARKVERLFASSAEPSDVSIRFNNTESFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH19</accession>
    <name>A0A0N5CH19_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH19"/>
    <dbReference type="STRING" id="174720.A0A0N5CH19"/>
    <dbReference type="WBParaSite" id="SPAL_0001714400.1">
        <property type="protein sequence ID" value="SPAL_0001714400.1"/>
        <property type="gene ID" value="SPAL_0001714400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000145">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000276">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF93">
        <property type="entry name" value="GALECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="151"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001714400.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31445" checksum="85C78948F542F2BE" modified="2015-12-09" version="1">MTQEGSYPIPYRTKLTEPFEPGQTLTVKGKTAEDSVRFSINLHTAAADFSGNDVPLHISIRFDEGKIVFNTMSKTEWGKEERKGNPWKKGEDIDIRIRAHDNKFTILADQKEIKEYDHRLPLSSVTHMSIEGDILITNIHWGGKYYPVPYESGIGGNGIAVGKSLFINGMPEKKGKRFYINLLKKNGDIALHFNPRFDEKAVVRNSLIGGEWGNEEREGKIVFEKGHGFDLKVVNEEFGFQVYVNDERFCTYAHRIDPNDINGLQIGGDVEITGIQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIT3</accession>
    <name>A0A0N5CIT3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Virulence protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIT3"/>
    <dbReference type="WBParaSite" id="SPAL_0001773800.1">
        <property type="protein sequence ID" value="SPAL_0001773800.1"/>
        <property type="gene ID" value="SPAL_0001773800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001773800.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23967" checksum="BCEE34D27A3444A6" modified="2015-12-09" version="1">MRYINDLRNMTTSQLQTTPATGAYKYKEFEDVRGLYAPDVKAIIMERINDLLRSGQLVYERVEKPNSIAIRIGINGDSDQGSTKFNFQLEVKENNHSVNNLSILTIWFGQDKTNLIHHFMKNPMQQLDSIIENGWHVVINGSKTKVIFQPFIVADYMVLYSFFGLKGAASSYNCIQCERWASGAKNRLNVLSYEITDKFQLRDVNTVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIY2</accession>
    <name>A0A0N5CIY2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIY2"/>
    <dbReference type="WBParaSite" id="SPAL_0001778700.1">
        <property type="protein sequence ID" value="SPAL_0001778700.1"/>
        <property type="gene ID" value="SPAL_0001778700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001778700.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19824" checksum="928C499BDE2B25E8" modified="2015-12-09" version="1">MVCYMQTSSSQDSKVEEVYDQMKEIMSGFKKLYPLSRNNIIIGGDFNAKIKCTIRRGKFSNSAHLENNERGTKLELWTESENLSITNRLVIKKTGELDYFLIHSAKRASFIDTRKIKRFNIRSDHKPLLLKVKFGKQDTKQYSTRKKPRIFSLDELNQDIINKTNNKALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2G0</accession>
    <name>A0A0N5B2G0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2G0"/>
    <dbReference type="STRING" id="174720.A0A0N5B2G0"/>
    <dbReference type="WBParaSite" id="SPAL_0000026700.1">
        <property type="protein sequence ID" value="SPAL_0000026700.1"/>
        <property type="gene ID" value="SPAL_0000026700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000026700.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27019" checksum="8F2BC6B6DACF9004" modified="2015-12-09" version="1">MGNPTPTAPPVSDIDVTMLSPPPYSQIDTNTPSNNGIIEDQSLTGPPPSYFEIFGEIRQVEDPKGFFTYVGKVFRVIVNTLLVTILLSLFNIVPISMIIIGSLNIGNCRIEKYIPIWLICFGVTLLLRSVLQLVIKKLYGPNVLTAINESNSSVLYTLSLIGKILNLASLIFFIWGLQMISANIGSVNFFKKDGKKYCDHLTFILSTVIVFFIAAILALFFCFMVCCCGCLCFLNIGNRRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2S9</accession>
    <name>A0A0N5B2S9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2S9"/>
    <dbReference type="STRING" id="174720.A0A0N5B2S9"/>
    <dbReference type="WBParaSite" id="SPAL_0000038200.1">
        <property type="protein sequence ID" value="SPAL_0000038200.1"/>
        <property type="gene ID" value="SPAL_0000038200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="230"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="432"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
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    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="SPAL_0000038200.1"/>
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    </evidence>
    <sequence length="773" mass="88954" checksum="3C78568B29C97F43" modified="2015-12-09" version="1">MSTLKEAFEKAKPKARIQYGEYSFVQFPSEYRIPDVIKNLPKVSAQKDQRNNERNSTSQFPQNCSGHSLDNGPLVQTFYINTQQKPTNPPTVEPQNYVDDNYDDFYDDSIDFSDSNNQSSTNSNNTLNITGSSDNNVSKEYNPIDDTIRHNNNISNNNISDDYHRFDDSTIEGECEDDIYDEEVTFLKSDAKEFANGHELLPQDKLQEMNKVLNEVFGYSSFKEGQKEAIIAGLLREDVFVLMPGGSGKSLCYQVPAVIDLGITVVVCPLKGVFEDEVAMLTKLGVPVQSLTCNIDKNRYSYFYEQVLSGEKKIKLLYVIPEIINGSENFQQFLLDIHEKGMLARFVVKDAQCISKFSHNFRTDCTGLNCLRDNFQNLKIPIMLLSSATTPKVVFDVISSLNIRSAKIFTSSFERSNIKYDVIHRTAKSQDTLLRKIKNIFPEGSGIFYCFSKKDCETLHNSLKDYGLTSVIYHCGMDDRSRREAQQKWMSNEVQVICGTTAFGIGVKKRDVRFVVHFCMPMNVESYYNESGLAGRDGLPSYSAILYSYLDSVREKKLIADNNNKYNLLSKDKPIRRSIQFYKVNQILWYCESIHECRRKFLLQYFGEKYDLDGCLRDSKTVCNSCEISINRVPRYKFFDFTTEAERILKTTIDYTLTMKQMSDCYRGRVVKKRNSDDVVQPVEIFGKGSRLTEEDANRFIIRLITDDYLKEDVKVIEDDNFTKITGYLALTSKGRKFLSSTERSKIHIYIEMKQVKRRKTTKYDLVPNDESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3U7</accession>
    <name>A0A0N5B3U7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3U7"/>
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        <property type="protein sequence ID" value="SPAL_0000074700.1"/>
        <property type="gene ID" value="SPAL_0000074700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893688" evidence="2">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000074700.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16296" checksum="51B4FF159F82B25D" modified="2015-12-09" version="1">MKFFISFLCLLGFINFSYSLKASPDSVGETKRDELLNEMETKLERMKKIQILKDKFKDVNPNMEMGNYKQYVLMKPFVELGIKKNLRDVKALVSQIEEKLLPYLTQDFDKSKRSKRSPNVAAQAGWDNDDGDIIYLTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4C6</accession>
    <name>A0A0N5B4C6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4C6"/>
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        <property type="protein sequence ID" value="SPAL_0000092800.1"/>
        <property type="gene ID" value="SPAL_0000092800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893741" evidence="1">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000092800.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40010" checksum="CDB0CD9864F43CF1" modified="2015-12-09" version="1">MYKIIIILLLVHCIIDNINGCIPIGMPNCDCQQSPDCGGCLSKTYYYNYDQPSSYHQQYAYPTLIETSNQLPSPPPYPFTNNINQEPVIESNFPGMDSYLTTIPYSIPKQNTPEYFEADRILASSIKKINNEDAYRHSQEVSLLEKNAIEKDDDVTSSFKIETTSLPQDSAMNYPTADVSTNVNTGFEITVKKEVNTTSESYNNYYQKTNIVNAGNTLPDPSTISPIPYDPKDVIYKIKHESKVKDTEIPLQSMYYGYKSYPILRSSDIQRESNFTFKNYLNTICNGDVISKGQESSLKIALDRCNNLKCSGMNIKNITSGSPLKTIPFLEVVYLSKINDKMSLQGYSCFTSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4E1</accession>
    <name>A0A0N5B4E1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4E1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4E1"/>
    <dbReference type="WBParaSite" id="SPAL_0000094300.1">
        <property type="protein sequence ID" value="SPAL_0000094300.1"/>
        <property type="gene ID" value="SPAL_0000094300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000094300.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="59525" checksum="8C7EAEDA545C4669" modified="2015-12-09" version="1">MDRKYDVFIESERGTGKKLGYILPIINYISMIQESDGCESTDVPVAVILMKDMDVCKEVELKISKLYPNVKIGHLFGYSKDINMINEIYKDCDIIIASIVRFIKVIEDDNFSSFKNAISKTNFIVVEESEELVELFWDNYLKLLCCDFFNRKAPEQIRIFSSCGLVDLTPEMFMKKYAQDDYVIMKFQNNVDCPPKESTKPFPAFDAPDIHKKENVFGKNFQDFVNYSDIIVSRPQHNIIVNNFTNNQHFTSNRSYNRHSFPVIYDGYGTNNFVDFLRPRHIVDTFSNNYCNLYYQEQKRVQQSPITPLEEPRIISQFHSDQNYPDYLIEEVEDNELDSLSFMDSFTSTGILRKLGVLKINIFDSFNKLLEILKSIFEMDNTFKVITFIKRPEGCKYASYYCRCHGLNSRAITRVHDTDNAKKNLQFFEATDGAVLFVEDKYKNSLIRNLRAHVVITLNLPDTEDDFEEKIRYLGDVNGNGGLFIIMGTRDTVNKEWIKRRMNNMKRGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4U9</accession>
    <name>A0A0N5B4U9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4U9"/>
    <dbReference type="WBParaSite" id="SPAL_0000109800.1">
        <property type="protein sequence ID" value="SPAL_0000109800.1"/>
        <property type="gene ID" value="SPAL_0000109800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893774" evidence="2">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="94"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000109800.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38714" checksum="3141E694B5C39045" modified="2015-12-09" version="1">MSRKTLLPVLLFIFLNIFKVKTGTYDEALSLIAYNLSASAYADDNEENIMQCLKKSYPNENANILHHSTFQCDDTNSDTCGGIYANLPDIDTTVIAFRGTKQSLELIVEAIQSLEDFVEYDCLQQNVISNCGYVNKYYMKASEMAYKTFINETINLSSLMNNIVITGHSLGGALATLLALKLTLNGVPGDKIHVITFGEPRIGDYNLANTISQNVPNLYRVVHYQDIVPHYPPCSSDNNNGCMPISGKPYHHPQEIWYNQNQKMTKGVYVTCNSTNGEDNNCSDKYISVIQSLLHGGWENEHMEYFGYNIRSYGTQGCNEAGKAKIFFFQILFVISSYVFYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B511</accession>
    <name>A0A0N5B511_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cnd1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B511"/>
    <dbReference type="WBParaSite" id="SPAL_0000115700.1">
        <property type="protein sequence ID" value="SPAL_0000115700.1"/>
        <property type="gene ID" value="SPAL_0000115700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000115700.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41151" checksum="F41D862E795A53D4" modified="2015-12-09" version="1">XIFECDSAIEVINYTSMALTSDNKNQIVLFLLALGQNLRFDKFKESPGFDKIICNMFCKIMMLITNYGANGINIVLSVLNGSGNNKTITSADFGVTSDVTEEELMDMDVNDEDGNDVDEEDKGEETVLKRRFSEFDYILSFATIFEYLNPPTNKVKDIAKLMVANIKNHRESLDEDREFISTLLKCGDFPIKYLEALMYVGEYFLKENNSDVNEMGKHIFLEMFSNLDYNREEIIALLVDNILSKDDVSYNALRTIHVIVKKCPYEFSSHIDYYLKRTSDQCTKFEPRLLRVFFKILSSLSISCSEEQVGTQISSLYEKFDQYLKSTDNNSFRVALSANIVRICELIRKDPEKYSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5C1</accession>
    <name>A0A0N5B5C1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Foie-gras_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B5C1"/>
    <dbReference type="WBParaSite" id="SPAL_0000126600.1">
        <property type="protein sequence ID" value="SPAL_0000126600.1"/>
        <property type="gene ID" value="SPAL_0000126600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000126600.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50063" checksum="56E21F087DF4CEAA" modified="2015-12-09" version="1">XVVDETGDSGKPLLIEALFNVSITFTGQDKIIFEEFIIELEGLFASENYTSLEIVMYSSFKLKKFFLKYPVFYKQCQFLSIGSWGTFYDLIQVGVYLSADKFNGCLIVNEFGKFDLIEAFLQFKSKCPNPAAFEVYISQLTLILESTEYSESEKYALIYELILQIFAEFPELKEEFLELEIGTFGSIYMLQEISVQYYRMKEIKKLFKGKPKCEFVSALYSCLSDSKYQLSMSNKGYLKILFDKFSVIIANDTLTYAEQIKAISYQYRQFIKTFGYLQETILSFEISAEFGTFGDFIAMFAFGESQECWPEDFLTFPEVTTEVATTEAATTEASTTVPVTGDCSTASSVVLQVVGTQSILYTSAMTSWSTWAAIEKANWKTFCDKIYANYVISTTMTEEAKVTAIIADINAYVAFYYYREEHVHSIQLGTWGTVGQLCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5T1</accession>
    <name>A0A0N5B5T1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5T1"/>
    <dbReference type="STRING" id="174720.A0A0N5B5T1"/>
    <dbReference type="WBParaSite" id="SPAL_0000142600.1">
        <property type="protein sequence ID" value="SPAL_0000142600.1"/>
        <property type="gene ID" value="SPAL_0000142600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF48">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000142600.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7946" checksum="140E7D9D0A7883A5" modified="2015-12-09" version="1">NVFIIVLDSLSHSNFIRKLPKTLSVLINDYKSIIFNGMTKVGDNSFPNAVAFLSGKRIMTPGYEDEINIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5T3</accession>
    <name>A0A0N5B5T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5T3"/>
    <dbReference type="WBParaSite" id="SPAL_0000142800.1">
        <property type="protein sequence ID" value="SPAL_0000142800.1"/>
        <property type="gene ID" value="SPAL_0000142800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF55">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000142800.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="85691" checksum="4D32E7B4C387AF1D" modified="2015-12-09" version="1">MNLDQSTYSDFLESLHLRDHSILEIMRKSFLQNGNTFFNVSTVSKDCNEDMDLIVKTINESVYFDIFGNIKINFNNSIMINIVLPMVDSMGKIPNGILLGNFISAGLKTECESINAIVPNRTRPIEGAYGRASINIPQNGTKYTGTCVLGKVFTWDICLPKSCQSHNDMLNVIRHFKISKNASEVSPICDVGTFADNVEMNYKGYIVAYLMLFIFSWSILASVIDLFIVPILKENDSAILHHKLFKFIQTMSLYTNVKTIMKLPKKVVPPKKEDGSKTKFVRSEIISILHCIRAISIIWVMMGHSLGFIMLVIVNPKDMYAIFGDYSKQFLTNAYFSVDSFFFMSGLLLSFMFFKQLKRNRRHTLSFRNFVMMYIHRIIRLSPSYYMAVAFYTWVFSPYFLKGMPLYLLESLKGSDSCNEYWWANFLYINNYVDVKNQCYLISWYLATDLQIFLFFPVILVPLAINVKFGLFVSVLVLVLSTAANIFEVLHYYFPPSDFSYGWMDPRMKDYTDYTEFMYDAPWIRCQIYIIGMLVGYFLQMKKSLKIPFFLNILGWILSLAIMVADVITIRDWVSGKPMDLFPRAMYSAFSKMGWGVALSFIVISCFYGHGGIINRFMSWPFWAPLGKITYSTYLIHLMTITYVIGGFEGQFVFLSVWNTFIYIILPIIVISLFFAFFWSAIFEVGVGRIEDLLLDRRGTKKMNVNSTKEDIIKKVEENHISEKINDGWRYSIFSINNPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6H2</accession>
    <name>A0A0N5B6H2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6H2"/>
    <dbReference type="STRING" id="174720.A0A0N5B6H2"/>
    <dbReference type="WBParaSite" id="SPAL_0000166100.1">
        <property type="protein sequence ID" value="SPAL_0000166100.1"/>
        <property type="gene ID" value="SPAL_0000166100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000166100.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27365" checksum="87BEE8083BE60DE4" modified="2015-12-09" version="1">MFFRSFTTKSSINLIAKCNNISRNFIRSMFIQTQETPNPLTLKFMPGKSILKDNSRTFDFTSVSEAKKSPLALQLFRIEGVKGVFFGEDFITITKQSEDLHWGVMKPEIFATIMDFLNSGKSILNEDFVESDEITDTTILPEDDDTVAMIKELLESRIKPMVQEDGGDIIYKGFEDGIVKLKLQGSCTGCPSSQVTLKSGIKNMMQFYVPEVVDVIEVKDEEDDIIEKELEKLEDKLKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6W1</accession>
    <name>A0A0N5B6W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6W1"/>
    <dbReference type="WBParaSite" id="SPAL_0000179700.1">
        <property type="protein sequence ID" value="SPAL_0000179700.1"/>
        <property type="gene ID" value="SPAL_0000179700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000179700.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="34461" checksum="92B78DE12B976A6D" modified="2015-12-09" version="1">MKFETNFDKYDLSNVGKMEECYKKVEPLLYNSNILGVIEDLRYYKEKNVRNHTEDDLSSCNDKIFYPQEILDPYLGIKGWYDSKENTFYINSDAIKEPSFSKDYPTPLNFGGVGYTIAYEIVHAFDNKNYKLKLRGDYENKYNVTDWSIKNFQNRSDCFVEKYGMQNESITNKNINGTLTLNENIADNGGLKLAHRAYMKYLKEIGGKDIEVPAYNQYTDEQLFFISAGRKHCTYKSKDKLENQKKTDKHPPGEIRTNMALSYYKPFYDAFKCSYNRKMNLKGKDKCELWKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7X0</accession>
    <name>A0A0N5B7X0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7X0"/>
    <dbReference type="STRING" id="174720.A0A0N5B7X0"/>
    <dbReference type="WBParaSite" id="SPAL_0000214400.1">
        <property type="protein sequence ID" value="SPAL_0000214400.1"/>
        <property type="gene ID" value="SPAL_0000214400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000214400.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19026" checksum="C98BBFEA5F9E9D8C" modified="2015-12-09" version="1">MGKIVKADKKKWNDVEVDGKLLKDPEFANLVSVEESCDEPATKKSKKDVGKNDMKKGSGSSKNKDDEYFDDYVNEELANQDSSRTELERKNGSENKVGNREENKNEGKQMTKDSGKESEEISDEELEDEELDGEESDREIDEELEGEEVFDEEIDEEAEADEEETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Y2</accession>
    <name>A0A0N5B7Y2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRRNT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Y2"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0000215600.1">
        <property type="protein sequence ID" value="SPAL_0000215600.1"/>
        <property type="gene ID" value="SPAL_0000215600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051295">
        <property type="entry name" value="LGI_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367:SF318">
        <property type="entry name" value="LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893925" evidence="1">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000215600.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47752" checksum="5EB12FC0299701A4" modified="2015-12-09" version="1">MEILFLIYFIILLSFISPDNFCPDGCFCQEDESLITCFGIDIERIPSNWPTHYKKIHLIECQLTTLQKNAFRRWSQLEEIRIERNQKLDLIDKLAFKGLKKLREIHILHNPKLTILLKSAFSSIQNEMGLNIHISNNSLEIIESGAFKNANNIRNLKIQEKCFTLQEESLGSITQIDFIFLSGLCSIKRFAFTNTSRVHSFNILNSKFSILPQAFSYLNHVFQLSIFDSTITLISENSFYNIKTVGTIKIEKNTIDVIEGRAFVGMENVGSIIISNNNIISSLSTPETLLIDPGSKIEFRENNVNCNCEIIWMDRWEDKSFAEENYCGPNEGRKSVFFYRPPDCHLVSLESLSSKNDRIPDDKKNKTPEIENFPPSKLLTNYVTSGYTPITNLKYNLSLIIPLIFYLIINVSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8E8</accession>
    <name>A0A0N5B8E8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DSL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8E8"/>
    <dbReference type="WBParaSite" id="SPAL_0000232100.1">
        <property type="protein sequence ID" value="SPAL_0000232100.1"/>
        <property type="gene ID" value="SPAL_0000232100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894125" evidence="6">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="7">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000232100.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="62746" checksum="A80BED49FF3258B7" modified="2015-12-09" version="1">MEEFKMLFMIVLSLLHTIIGQMNVEMEIVFNNKEYEQLCQNYTTNIHIIISVDPRNNDQNSKTVLAQYLTENLYKKRIKANFQGNWTNLSKTLHTVIQSQCPIMMLKDFVITIPQHLDSSGNIWKYPSYPSDINLTFNFTCISGSYGPTCTKFCESPLDSNLHCDSNGKLICNDGFKFRDEDKKYCIPICFESCNKSGGKCISPGVCLCNDRKAREDCQICEESCLINKGISNNNLISNSDCFYNGVSIPNNKIREFLCELVLCNNTKIHIIENVCTSNNCRVQKTMCSSVKECVPFEKYPDYCLSGPCSMKKKQYFCDMISSNCTECLSFTKWISEGMKRKTKNNLYFILNDSPIENKIKFSDFIREIFLLLQKAEMFDIFINFDKIIVNKMNVLVLSIYSPSTSEKEAKNQVEGILRFSQNRSLVMRRFNKYDLVEEKFQKESITKDEATMSVFFSILSYNYIFFGIFIFFGLLICIFIFFIILLLRPLFCSREKLNNVDILVVSGPVISEEKRHLIRIKSILRNNSPPPKYKEKETTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8F7</accession>
    <name>A0A0N5B8F7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8F7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8F7"/>
    <dbReference type="WBParaSite" id="SPAL_0000233000.1">
        <property type="protein sequence ID" value="SPAL_0000233000.1"/>
        <property type="gene ID" value="SPAL_0000233000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000233000.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14105" checksum="6EBE2A90650F44A9" modified="2015-12-09" version="1">MDRKNLLKLITSACCYRNVILTMLKFRVESLYSMKKVLTKMGLVTPFNDKSNFTGITSNVGFWFENIVQKVFIDVNEKGTKVEPEIPSIVLNHEEEIIVKANHPFLYIVLDNEKILFSGIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Q1</accession>
    <name>A0A0N5B8Q1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Laminin subunit alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B8Q1"/>
    <dbReference type="WBParaSite" id="SPAL_0000242400.1">
        <property type="protein sequence ID" value="SPAL_0000242400.1"/>
        <property type="gene ID" value="SPAL_0000242400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000083">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000388">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="18">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="419"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="511"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="557"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="603"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="649"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="749"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1356"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1402"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1447"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1495"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="17">
        <location>
            <begin position="1567"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1776"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1937"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1984"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="2031"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2639"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2833"/>
            <end position="3002"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3008"/>
            <end position="3177"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3244"/>
            <end position="3418"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3424"/>
            <end position="3604"/>
        </location>
    </feature>
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        <location>
            <begin position="2239"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2362"/>
            <end position="2393"/>
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    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2487"/>
            <end position="2521"/>
        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
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            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="485"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="532"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="557"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="559"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="603"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="605"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="624"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="649"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="669"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1356"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1358"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1470"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1495"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1497"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1516"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1795"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1956"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2004"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2031"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2033"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2052"/>
            <end position="2061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
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            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000242400.1"/>
        </source>
    </evidence>
    <sequence length="3607" mass="404303" checksum="E308A29796F11C72" modified="2015-12-09" version="1">MREILIYQYLLILLPLTIYGFLEPPQFNLAKHKKIVATSTCGELHGKPYREIFCSLASSLPYTPYQQMTSAIDGNPFREARAEHSFLREGQSCDICEANTTLEHPASNMVDGSNAWWQSPPLSRGREYEKVNITIDLGQEFHVAYIYIAMANSPRPATWVLERSTDSGKTFKPWQYFAEHNSDCARYFGYSSLAPITEDDSVVCSSEYSKLQPMDNGEIYINLLENRPGRLNFSNSPVLQEFARATNVRLRLLSVATLHGNLMDVHRGNDPTVTRRYFYAIKEIKIGGTCACHGHAKTCDYLDKARSDKLICRCEHNTCGDRCDMCCPGFEQKKWQLSRSGQFFECEKCNCHGHTNDCVYDEELDRINGSLDIHGKYSGGGRCLNCQHNTKGVNCNECVDGYYRPEGKKWSDIDVCKKCTCDPSKHTGRCSEGTGKCECLPQFTGENCDQCAPGYYNEPECKPCECFYQGTVGNVCLPIGDKCPCKANYEGQFCDICSPGHFNLTSGCEKCDCDIDGAANGECDLTTGACKCKTNYGGEKCDKCAVGYYNYPTCTFCQCDPSGTEGGMCDSTTGQCLCKIGFSGDKCDQCEENYYGYPNCKPCNCDSSGSNSTQCHQTTGECPCRENFAGRVCDKCVPGYYAYPDCLPCNCFAQGSKGKTCDSKGNCHCKENFQGKRCEKCKDNFFNFPICEECNCDPDGVTKDFGGCDKVSPGELCECKSNVIGRTCNKCKETFWDLKRYHEEGCISCGCDTTGTLSGLNLCDEKKGQCKCKLHISGRRCEKCKDGFYNKNDINFLGCQSCKCNLAASQGNTCNAETGQCHCKPRVTGEKCDKPIEKHFFPTLWHMQYEAEDGKTPDNKGVRFSMDSEQFGNFSWRGFVVFSHIQEEVHLVVDVMKTSVYKILAHYHNPTNVDNEVSVSITPYSLVSQEQPQQSFESVISPSLMPTTKVINPDNKPIPISHGRHIIKLKTKKRLYLDYIVLLPSEYYEGHNLKENVDEICKKDQKPDEYCVKLSYPPMGNTIKADKPGEILDEITFNVPNSGEYVVVFTYNYDRPEIEPASIWDNEKTFEGVVNFVHCPYQTPCRELAVHSGTPTIFNISNNGEYKINMKYVKQKDLEIKGIELVPLNEWKDSYLNVHHVCISLNNKCIDQSYPDAQSGIVTEIEESDGNKPILGEKLPFEIAKKNKVSVMSLDNSQNTIEINGIVDKENYYNFIVDYYNPNGKERTLNVLFNDNNEHTYDAKLTINYCPSHSGCRSIVTFDQGQLYQYVKDKYSLTIIGEEDLYEPIYFDAVTAVPSQLFNQNLLKLQPLDVGKEFTSKCSENFFKNDPESVDEYCKEKIFSLAIDFNGQAQPCSCSASGSLSFNCQEYGGQCSCKPNVIGRKCDRCAPGYYSFPSCIKCNCGPNESCDEYTGQCSCPQHVEGKSCDKCVKYAYGYDPLIGCQLCGCNKDGSEGGELECDPLTGQCLCKDNVGGRKCDSCLAGFYRFPYCSECNCDTRGTTSDICNSETSECICKKNVGGRNCNHCLRGTFDLTDKNPEGCSSCFCFGTTDSCISSMFNVYYEEFDNFAWKSDDVNGIVSGNNGEITYTPSEDKSPNSVYLIYSIDSDNDYTGIYGQLISYYASTTPNDKDRVFNNEPDIRLIGEHGIAEAWLPSQPADPSKRFVVSIQLLPEFWVTKDGDHVTRADLMMILVKLKEIQVKVSYYERPLKAHIYDFKMTRAYPEEKNGFFTVSRSTSVEKCECPPSYTGPSCQECAPGYYRIKSGDYLGSCVPCECNGHSGNCDKDTGICQDCLHNTMGDHCEICVEGFYGNATSGTEYDCLSCPCPLKENGENFAIGCDVHENGLPEKCYCKEGYTGEICDRCDTGYFGTPFRSDGSCQKCFCNNNNNLTVPGSCDDVKGFCNYCQYNTSGLYCEECEDWFYGDAVEAKNCTACNCVIEGTEECDKTSGQCVCLENVQGETCNECIPEAYGFDSGEGCKMCNCAEASSSKQCDLKTGQCACMPGVTGLHCDRCMQGFWNYSPEGCTKCDCEADLSKGTVCDVNTGQCHCQPGATGPRCDQCIANFLKIPEYGCRQCDNCVFSLRDMLDVMEGTLQTVVETVDSTPPAALVGAKLSKYDKEYKIYDPLIQKLITQKDNETFLNELAEVEELKKNSSLNVIRTNMTLNHLTEYIESIKSLINETIELNGDAKYMYQTAKNIVDGIREIPTLFMTKQNIENREYLIKGASNILSTMKSNDDFENRKDKINKELDEIKDKINDVDRRTSKNKDLKKSIDNLGKEIDESSKLTNEQLEQLINVSSIVKQLNKTLNENILFRINAAIKGLNDGNQNLPIMIANIDKKVNETKKILDEYTNISTQLVDLKKTLQTYIDDLKNENDKISRKKRAINSNQLNVNVIKLERQSNEVKKMFENTKRVSGNAVEAGNVYQNITEIIRNADNTITKALDTCETGAKNSDGLENVVKEIKEENGKIMNTINTIRKDILNDIELKNHKIDGNLDELKEKVDNLKESVDKHKDIHNEPVDDEEFIKKVAETKKSLDDIKNDLNSIIADSDNVVEATNNFTNECSRINQEIRGTKAQVSELTKMSEPTIEKMKSFEKKITNFTSHLTTAQAKLAILREKIDIARNMANRIKLGAHFERGSSLELNVKGKTQDVAGFSDISFYMKTRSLSGLVMYFGNIGTSSSIEYIAMNLASGRPKVSINLGKTPIEVTLNTMVNDNNWRFYRIERVGRSISIHVSKPMSLENDETKQLILPSDKHVLNIDPSRGKLLLGGITDEVLPKKIVSKDFIGSIEEFRINNIYNSLWSYKKQTNVTGALVRPIFKDELTSDGVSFDGNGYIALPHEKWDVTKKTAFTMSFQTYVSNGLLFFLGKDNDYLMVKIENGYIKLLINLGSGDIEISSNKNNYADGHWHSLRVDRLDRKARLTVDDVDKVEGETLGSMSELKYDKLYYLGDVGYDTKNKYQVIPFRGCIKNFKIENNFVDLRKALSSKGVQMSCPTQIIRLATFTTPQSSIKFERTLIDKNIEISLKYKTVQNKLTLFTLEDANNSENEMNFVIDNGYLYLLLGGEEFGKSDFISASDGNWHIASLFIDRDSLKIFVDDILLKTTEKPEYIGDNFKEVSLRIGTNDEKCDPKYCIGDLIFNQKLINLAEGVVNDVKLQQCSVVTANEECISTLKPFTSSSENTSAEKQPVSSEEVIYTLPSDEDDNIPLTETTLPSVVYDSESCYTLGDNTGENRGIRFGLEQYSRVEYDESPELLSSNSMAISVMVKPTAANGLISYISNPSTTEYLSIYLMEGFVHFSYGNENNNIDLKSKINILDNKWHTIRAEREKNVGILQIDGKTENEGQTAGDMDILNLQSPVFFGGLSTDVQATYSKLFPNMTIKFTGCMSDFKLNEKDFTEKTNKIGVKNCSEANEIGMFFGPSGGYAVLNQDFSVGSNFKLEFEIKPRTKDAILLSIGVDDAFNFQLINGTLKLTVSTGNVQESIEFLTPYSGYFCDGQWHNIILYKNKNLISLSVNGKSKFLFLKGKKKTGGPVKDVLYLGGIPKDIKPRGLETTSSYHGCVRVSTFDKKSKRARKQINILDRVQHFGDIAPNLCPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9B2</accession>
    <name>A0A0N5B9B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">M20_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9B2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9B2"/>
    <dbReference type="WBParaSite" id="SPAL_0000262800.1">
        <property type="protein sequence ID" value="SPAL_0000262800.1"/>
        <property type="gene ID" value="SPAL_0000262800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="209"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
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        <ligand>
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            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="418"/>
        </location>
        <ligand>
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            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000262800.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52762" checksum="806A4F449EA4EDB5" modified="2015-12-09" version="1">MTNQIDNLFKHIDSKKSHYIERLRKAVEIPSVSAEAEHRKDVFKMIDHAQKELETLGAKCEQIPNGKQTLPDGQVLDLPPVLFGTYGSDPKKKTLLVYGHLDVQPARKDDGWDTEPFKLTEKDGKLYGRGSTDDKGPVLGWVNALEAMKELGIECPVNIKFVLEGMEESGSEGLDEILIAHQNTFLKDVDFSCISDNYWLGKNKPCITYGLRGVSYYCIEIQGVKQDLHSGVHGGVVHEALNDLIWVMSQLVDNDGKILIEGLDKLVAPLTKEEEELYEKIDFDVKSYADDIGAKKLISMDKKQILMNRMRYPSLSLHGVEGAFYGPGAKTVIPSKVIGKFSIRTVPNMEPKEVDKLVVSYLNKLWSKRGSPNHFKPIPLQGGRSWVGDTKDANFTAGRNALVKVFGVEPDYTREGGSIPVTLTIKELTKKSVMLLPIGASDDMAHSQNEKINVSNYIEGTKVLATYLLELGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9S7</accession>
    <name>A0A0N5B9S7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9S7"/>
    <dbReference type="WBParaSite" id="SPAL_0000279700.1">
        <property type="protein sequence ID" value="SPAL_0000279700.1"/>
        <property type="gene ID" value="SPAL_0000279700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894012" evidence="2">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000279700.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19809" checksum="2B6806B87956F92F" modified="2015-12-09" version="1">MHFIKYLTIFFLLAVQYSFQDTSSSESSLSSSEENELEFAKSQEMPLPNDVTLVNDVKPKKSLVKKLKDNVKKQKESVKSALKSKLDKANIKKGLEKTKEKVSDTFEKGTKTLEKAFGKMKKGLNTLLKKKNSGKSDSSENDIRKKRSIVGKVINGFKNVASKGTKKVKEALRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Z6</accession>
    <name>A0A0N5B9Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Z6"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Z6"/>
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        <property type="protein sequence ID" value="SPAL_0000286500.1"/>
        <property type="gene ID" value="SPAL_0000286500"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000286500.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="30308" checksum="C656E8BA9D77CB1C" modified="2015-12-09" version="1">MEEKSKIEEAEKLKNLAFCGVAISTVATLVCAISIPMLYSYLQAIQSNMQSEIDFCKARSGNIWKEITRTQVLTKVTGGRFARKAGYGKGRYSFGDEFRFLHDPPLGGGCCGCGVSGPGLPGPPGPDGMPGADGEPGAPGRNGPDGPPATPAPRFEFCFDCQPGPPGPAGRPGPKGPPGKPGSPGSDGIPGNIASSGEPGMPGEPGEPGRPGNPGPPGEPGIVLDTPAPDGPPGPPGPPGAPGTPGQPGEAGVPGSDGKPGEQGDPGQNGPPGNPGQNGNEGPTGPQGPRGSCTHCPLPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAJ5</accession>
    <name>A0A0N5BAJ5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAJ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BAJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000306200.1">
        <property type="protein sequence ID" value="SPAL_0000306200.1"/>
        <property type="gene ID" value="SPAL_0000306200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000306200.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="81810" checksum="85D62009D5CCEF18" modified="2015-12-09" version="1">MKDVYIPPLQGNSSVNNDINFTKFLNDVTEATAFDADILFLNRKAQELRKVNSIGGPSSKMLFHINKKSFPRKKKDISIPERLLPQLQKALAEEVETYVLKKNPHNLSLYFQKVIDNNKEISNNQIWRKVLYFFNKPIPNKYKTTLELRNSEEFFERLMQFSITYLQKEFKEHMENVVSKNLKLAKRGGRPGNEYLIEAFLNVVRLKCYVDVEDGIFGSHPIWQVIFCAFRIGDYELVGRCVEKISNKGSYKKIIDILKRSIENIKLSKDEEESLKAEYDEEISKSRDPYKKAIYGAFLNKEVNEVNDNLENWLWSKLISVYVCKDDGKTKFVELQKLIKEECGENYFVDDQRNYTKYFGVLWLTGQFEAAIDILYRGEYLIEATHIAILCHEAEFLLILPNLSDEMLLPCNYLNTYLYGLNFPKLIIYYMQRFEESDVLSFIAYGQFLKNFETSSNENLFAVCVSRVLCDNDIQRDEILGYLNEDGTVTEGILHRYGNVCATEVITQTAKDLNFQGKRIDSVKLYILIRDVDMASKILCELLGSIIISKGRNRSVVLDFASWFLKLTSKREYKINDDETSSTLQLLLDLGTFFEYAQEKRNREAITYMQQFEILPQYIDSVQKAVDAYHTMTTEIRMILPDIVLAYVNCLVEQINDQNDETEKIFLKEMGQALFQYVGRIPYKFPPHIHTKLLQLFGFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAU1</accession>
    <name>A0A0N5BAU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAU1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000315500.1">
        <property type="protein sequence ID" value="SPAL_0000315500.1"/>
        <property type="gene ID" value="SPAL_0000315500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000011">
        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000071">
        <property type="entry name" value="Potassium voltage-gated channel protein shk-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000214">
        <property type="entry name" value="Potassium voltage-gated channel protein shk-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="118"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000315500.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58902" checksum="02F769F8CA0AF07C" modified="2015-12-09" version="1">MIFRKIEQILHVHPEKYRTRGAVGSRRSTPCKKDSSNNRLHIRSASEELRQRSLRSSSDSASINDSNNSKQLEELSIPIPTDIIGNGGRKKSDTEYWNPLTSHNHISDNSNIKWKNEEVITINVSGMRFQTYESTLARFPNSLLGHPAKRARYWNSKTQEYFLDHSRYCFESILNIYQTNGDVRRPELVPLEIYLKELKFFEMNEEVMENFWVSEGYEKPVEQIMPNNPIQRYLWELMEYPDSSVPARVLAFISISVIVTSIVSFCLETLPDFRDASETLTETGYSKWNNPFLILESLCIVWFSIELFLRFISCPSKRVFMKSFLNIVDFIAIAPFFINLIWSEGNKNNSSTTSFAVLRVLRLVRVFRIFKLSRHSVGLQILGKTFRASVQEFCLLIFFMVIALVLFSSAIFYVEQGEADTRFTSIPASFWFVVATMTTVGYGDLVPTGTYGKLVGSLCALLGVLTLALPVPIIVANFKHFYRQECRLAAMRVSRQIDDASRYNESDEDYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAY4</accession>
    <name>A0A0N5BAY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000319800.1">
        <property type="protein sequence ID" value="SPAL_0000319800.1"/>
        <property type="gene ID" value="SPAL_0000319800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000319800.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8111" checksum="1AEEEFBA9B1B6A8D" modified="2015-12-09" version="1">MCNPAIIRSVLMCVLVKRKLQTGDEDYPPAVSTGRFMTEPNVNLLNYFTIKQNYIYINTVKTLSFYMINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBY5</accession>
    <name>A0A0N5BBY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBY5"/>
    <dbReference type="STRING" id="174720.A0A0N5BBY5"/>
    <dbReference type="WBParaSite" id="SPAL_0000353500.1">
        <property type="protein sequence ID" value="SPAL_0000353500.1"/>
        <property type="gene ID" value="SPAL_0000353500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000353500.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="55752" checksum="17A329AFF1DD443A" modified="2015-12-09" version="1">MESLTNFVCNLLHINHKNRDDDNENNQVWPRTLSLSPLEHIYGLVWMPKNVNTYERELLYSIHSLPFYFGSLLEDDDVQVQLLINCGDCFLTNPPQTTYNTPPSTSLLSRIKFFNTRRSYYTFSHYILTALGTNDIILKANIIFKRNTFVLEKLPDIDIHTFIAENNLNTISKPWFIEKKQIISGRGIKQAQPFLLSIDERRRYFRLGIFERKVLCLDSRRKIPVSVLSIEAYDRELQKKLINEANLLRNFGNIHIEKLWGLCCDDGECMIVLEEVVYGSLVPYLRTGNRNEGQLINFCYQISEGLRYLEDHDFILYHFNIYYLYITYNYTIKISLIGSSKEELIMSSPKELYEYEEAVIWLPPECFERNGTFNFLSLSYIFGNVVWSIFNNGMNPIFDMSKENRKSTTSLSGSKNFTFSSKGCIKKNYLKKLEMFQTSIPRNIIKNVLFKCWDVNINNRPNFAILCKEIKKLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDB5</accession>
    <name>A0A0N5BDB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDB5"/>
    <dbReference type="STRING" id="174720.A0A0N5BDB5"/>
    <dbReference type="WBParaSite" id="SPAL_0000400100.1">
        <property type="protein sequence ID" value="SPAL_0000400100.1"/>
        <property type="gene ID" value="SPAL_0000400100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000400100.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="55469" checksum="64D45C57052C449E" modified="2015-12-09" version="1">MISYNSIFIVLSCLFISAIYVIYINYDTEVLVEYPNSYKTIKSIKIKQDKRVPDKLIHKNYTLWKPKDFNLDCSKVISGDINYINMVRKNRFTIKEIPKDYKYDCDSIKSRGFYPKVPLSDIEANYPIAYARNVYNNYHMLELEFLVSYAPQNHYCFSVDIKSPELYMQLTSLSNCFNNVYISQTRYNMSSGGIYQALSTYECMKLLKNKKWNYLFILQNDDFPIKTNREIVEILIARNSSLDMEFCNPEPFIPYRINQNASWEYKSLNFFKEVEMNEYDKKFLSKKIQFSKGSYASGIPRDSIDYILNNISISKYLNQINTAGKYGEDEMVWQTLFSDSFLKIPHYVERNCLSTEYNEQIFMVRDAIWPDRKCKSDIIHHNVCVYGIEMLDQIKYMRRLFGYRFLPDHDFGAALCFAEYLVDKAYRMEFNKNDATFYVNLPSTKYQNANQRTKNEIIKNCTLKKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDT3</accession>
    <name>A0A0N5BDT3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syndecan</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDT3"/>
    <dbReference type="STRING" id="174720.A0A0N5BDT3"/>
    <dbReference type="WBParaSite" id="SPAL_0000416400.1">
        <property type="protein sequence ID" value="SPAL_0000416400.1"/>
        <property type="gene ID" value="SPAL_0000416400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001050">
        <property type="entry name" value="Syndecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030479">
        <property type="entry name" value="Syndecan_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915:SF1">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00964">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894129" description="Syndecan" evidence="12">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Neurexin/syndecan/glycophorin C" evidence="13">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000416400.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36353" checksum="100838F73BFBFF84" modified="2015-12-09" version="1">MNKLFFPIILLLITGLIVFGEIKNGNGYNKKAALSGKHNDIEIEGSGKDDYRGLPNDKNVGPNVDMEIESSAISTDDEDGDVVEEGSGYIPPEDPGKKVSISSVPITHDRDEEKDIRSTTKTIIDSFTKSTTTTTIKPSIIKDVVIEESTTKKVDTTTEKFPKDIIHEIHPDDEDQGNDDIGDSEDDDDDEDSEDDIKIENVVVEDNNVHETSTHPTTTTTSVVTEKPYVKTKGTSRPEVKYTKSPPVIYDDIEQFFASIHILTKPGFLAVIVGGLVIGILIVILFIMFIIYRMRKKDEGSYALDEPSQPPHYSYAYQKAPTKEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDY9</accession>
    <name>A0A0N5BDY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000421700.1">
        <property type="protein sequence ID" value="SPAL_0000421700.1"/>
        <property type="gene ID" value="SPAL_0000421700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000421700.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17262" checksum="81D5C6AD876737A9" modified="2015-12-09" version="1">MQNIILNKFNMYAEKKMCKKKLEKLRCLKECHKRKKTLLHLALKCYKPLPTLHEAKDLEEDETVPVNKNETNKNETKKNPSSNKITPTTNNNVKMMENDNEEYLKKEHTIKSFFLKININSYKIRSIVGSIFLLSSCRGSSSIRIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEP7</accession>
    <name>A0A0N5BEP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEP7"/>
    <dbReference type="STRING" id="174720.A0A0N5BEP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000447100.1">
        <property type="protein sequence ID" value="SPAL_0000447100.1"/>
        <property type="gene ID" value="SPAL_0000447100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="168"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000447100.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44792" checksum="46C8C139A7B07B30" modified="2015-12-09" version="1">MNSKDFNDLSFEKLSLGSGGDYDDEEDDGNVDDNFFYENESFYSVSGEDESKDTLNSWSHNITKPSRWKFRDPKSCLNKNLVSKCKTPSDYYNLFFDDEMIDFIVQETNRYGPTKDSAFIPTDEVEIRKFLAVIIQMEYVRLPKLKDYWSSDPAIGGHAICSSVMPRSRCKTLFRPGENVCIDESLVPYRGRISFRQYIPSKRYSYGIKIFKICSQHGYTHNMIIYAGKQDQPRKGTVAEDVVLKLLDDLLGHGRTLYTDNWYTSVPLARTLIKNKTNLVGTIRKNRASLPKSVTSLKLKKGQQVAAQTNDGILVLKWHDKRDVLMLSTTHDDLIDENGKPRVILDYDVGKAYVDISDQMASYSPYIRKTIKWYLRILFFVVIQAAVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEY1</accession>
    <name>A0A0N5BEY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NRXN1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEY1"/>
    <dbReference type="STRING" id="174720.A0A0N5BEY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000455100.1">
        <property type="protein sequence ID" value="SPAL_0000455100.1"/>
        <property type="gene ID" value="SPAL_0000455100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000455100.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8089" checksum="6A0FDE7256A97A28" modified="2015-12-09" version="1">MFMSHRLSKYDFDESLETLPHEGDYYDEDSEESTPICGKSGLCNCEKGNESVVDCRKENFGTHKHPLDTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF97</accession>
    <name>A0A0N5BF97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF97"/>
    <dbReference type="WBParaSite" id="SPAL_0000466500.1">
        <property type="protein sequence ID" value="SPAL_0000466500.1"/>
        <property type="gene ID" value="SPAL_0000466500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000466500.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16240" checksum="03DFE2A7DCF04259" modified="2015-12-09" version="1">MKQDFLTKQRGPKNRVALPRIFDDACHWDTWLLKDRGTVDCDGFCYKYQEALNNSGSYSYVTIRACFTQMFSTIAPVSAIDMKSPGHSYCSEQIKPLDCLADTNLIDYQCWCQGDYCNSGSKFSVSSIFIIFVAILFLFFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFE8</accession>
    <name>A0A0N5BFE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIR Superfamily Protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFE8"/>
    <dbReference type="WBParaSite" id="SPAL_0000471400.1">
        <property type="protein sequence ID" value="SPAL_0000471400.1"/>
        <property type="gene ID" value="SPAL_0000471400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000471400.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14470" checksum="978700B3DE5A95B0" modified="2015-12-09" version="1">MYLEDKNYYRKNKLIDRQQSLEHDSNAAFGPAIHTFESEHSCQLRCITTCAMHHLPDLNMPRWICPTENKEQIYNEESYGQYESSYISTNTSVFSNQTLILFIPLLVVILVILIILVLRKSSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGU6</accession>
    <name>A0A0N5BGU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox protein 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGU6"/>
    <dbReference type="WBParaSite" id="SPAL_0000519600.1">
        <property type="protein sequence ID" value="SPAL_0000519600.1"/>
        <property type="gene ID" value="SPAL_0000519600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000519600.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="37450" checksum="2DD9AD35B40B4A15" modified="2015-12-09" version="1">MNDNYYLNDKKLFYDPNSFFKLHYNQRSKSYNIDNREPHQDRIFNYSPNYDNEDYSIFKRNAISHSTLPTKYFSDYTNNNGGNRKFIKKSFNNSIRFAPTTTTIDGANRLHSRPLNSSDPYLKDLYSNDSSQWKLHHNNNFRSFPFFKKNENERYRSYDNISSNQKSRPINLYNNSPRNLFRYIYTEPRHEVHQNHLNKHTGDMLNVDYANRKESPNFYNITPILNNDCEEIYNHKENGISRRKKSITKQYMVYFCCLSFKWPPWRIEPLMEEDTKNNKMRGPINSQLTRSRDKYNGNNIKLTRQLYMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH28</accession>
    <name>A0A0N5BH28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRP15-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH28"/>
    <dbReference type="WBParaSite" id="SPAL_0000527300.1">
        <property type="protein sequence ID" value="SPAL_0000527300.1"/>
        <property type="gene ID" value="SPAL_0000527300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000527300.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16780" checksum="437747ED6D6CE746" modified="2015-12-09" version="1">EENKVDVAIPEETNFVNEVLPVSIGETEDNGLTNEVEEKNIKKNGRMGNFFKKTFSMDNMKKKFGKTSKKAEKKLKKGFNVMKNLAKKSRDSFNKLLKKGKPSSSSSSDSDSNEDENDRKKRFLKLLLPKQVSSQIKDIGGHVLNHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI46</accession>
    <name>A0A0N5BI46_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI46"/>
    <dbReference type="STRING" id="174720.A0A0N5BI46"/>
    <dbReference type="WBParaSite" id="SPAL_0000563000.1">
        <property type="protein sequence ID" value="SPAL_0000563000.1"/>
        <property type="gene ID" value="SPAL_0000563000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF494">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="229"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000563000.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="70958" checksum="DCAD7C675418BC5F" modified="2015-12-09" version="1">MKRNKGLSGGGRKFHDKARSLPSHKNCKDAKQKEIHVPKSSGSNPGKDSKKKSFSKEILRMEETQKEVESIYPIKNVSQSQLKRLSEFTKKCGDCKDGDKSQNYYKTLLISYLDLIIENYDGGCCTFNASKLVTLPIFNDVCHRVSEIFSSESTLLMINSETKNENFLILSDLHGCFDVLVYNFNFNYCIPKNKVIILGDYVDKGPDDAFMCFLLFLLKICWPDKIFLLKGNHEVRDMNRQKKFPNNCGNLLGDPNTFYLYNFVFERMPLAAIWNNTVYLAHGGISQWMNGREDINSIKRPLKLNRTLKTRLLITDILWSDPYRKTYNKKDNFSKFFAPSKRGCGYAYSKEGLENIMKYINVSKIIRGHQTSNEGFVEEYKNICYTVHSKPSSCTTTAYGSACQLSLDANNNAVVKQLKYKLDMDKNVIIKALEKFKNLWKNSKVSPYTFKQKCPYCLDKEEYHNELGCQERILVTHAQIMMWMSNYKTSTTTEMILGSKVNKKLKNLTRLLSRFPVYLDFCVWSKIGTSIRPINVIDDKENELVEAILKKIEKLEDKSIIKSNPKLTVDVLPFLLLNQSEIRKRKNYNFTSDDEEDDEETFDEKDDSEEDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI73</accession>
    <name>A0A0N5BI73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI73"/>
    <dbReference type="WBParaSite" id="SPAL_0000565500.1">
        <property type="protein sequence ID" value="SPAL_0000565500.1"/>
        <property type="gene ID" value="SPAL_0000565500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000565500.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21398" checksum="A427549E0B538B51" modified="2015-12-09" version="1">MSSTTVNRNSKKTKKTSTSGTKFDLEEIVAEVTKIKEQLKIMEKDFLAAEKLAKSTEPQCLKKVLSENKDITNVLTSTRIIRIILASSSPLSMSALAGLLIYVQPMISSSYIESQDVAVTFLGVIKDLYWDEIVKTCGMPVNSSMKIKEKNRIKNAQKARDLLVNVATNATAARISSNTSACTFKTCVNTFITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ06</accession>
    <name>A0A0N5BJ06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ06"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ06"/>
    <dbReference type="WBParaSite" id="SPAL_0000593400.1">
        <property type="protein sequence ID" value="SPAL_0000593400.1"/>
        <property type="gene ID" value="SPAL_0000593400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="2">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000593400.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14057" checksum="41349AD2296E976B" modified="2015-12-09" version="1">MLSKRDIRAMMLYEFKRGTNAAKTTQEINKTFGENLVSPSTVQRWFKKFREGSEDLENEKREKPESVLDNDVLREVVEANPRTTVRELARELNVSKSTVSRHLQEIEKTKKLDRWVPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ81</accession>
    <name>A0A0N5BJ81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ81"/>
    <dbReference type="WBParaSite" id="SPAL_0000600700.1">
        <property type="protein sequence ID" value="SPAL_0000600700.1"/>
        <property type="gene ID" value="SPAL_0000600700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894363" evidence="2">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000600700.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11641" checksum="2A0788B8E55E5B20" modified="2015-12-09" version="1">MVSFFIKTLLATIFFVFTASHPVAEKAFDSSLSSALENKKNEELSSFISANNLFGVEKKKPAPKKPAAKKTTKKGKVTTKGKATTKKAATTGAATTEAVTTEAATTAAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJC9</accession>
    <name>A0A0N5BJC9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuropeptide-like peptide 36</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJC9"/>
    <dbReference type="WBParaSite" id="SPAL_0000605500.1">
        <property type="protein sequence ID" value="SPAL_0000605500.1"/>
        <property type="gene ID" value="SPAL_0000605500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21525">
        <property type="entry name" value="Nlp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000605500.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8293" checksum="D9E0B945D6FACA99" modified="2015-12-09" version="1">MAIDLKQKLDFIDFFGPIAVWICFFSVVFIISVTCILWCCVTEDDDSTVFAKWGMGPKPKHKREQKYGANNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJE3</accession>
    <name>A0A0N5BJE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJE3"/>
    <dbReference type="STRING" id="174720.A0A0N5BJE3"/>
    <dbReference type="WBParaSite" id="SPAL_0000606900.1">
        <property type="protein sequence ID" value="SPAL_0000606900.1"/>
        <property type="gene ID" value="SPAL_0000606900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000606900.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22996" checksum="3B520A021AC5FD0A" modified="2015-12-09" version="1">MFTGAVISWNLVGMILWCMSLVEITDIDREYVESILDPRMFLNLQGVYEKYLIFKVISVKGRIASLFTMITVGIIGMTVIYTTYRINKIMAMKKDQLSLRTQQINRQLTISMLLNVSVSMMLDVLPVGIILMAAYFGIQMYGYAHIFFFTFEYQPLVNMVICIIFVKPCRNEFLRLFGIKKNSVIILKSGTYPVTNVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJU1</accession>
    <name>A0A0N5BJU1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJU1"/>
    <dbReference type="STRING" id="174720.A0A0N5BJU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000621000.1">
        <property type="protein sequence ID" value="SPAL_0000621000.1"/>
        <property type="gene ID" value="SPAL_0000621000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000031">
        <property type="entry name" value="Oxysterol-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000621000.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="89306" checksum="5B1DDC1D0EDD0319" modified="2015-12-09" version="1">MSSSKNSQAGSVSSINTSFNSFTSDNNGTTVTILKQGWLQKWTNYIKGYQQRWFVLDSKCSLAYYRTQSEVNHTCRGSINLQEARIVSEKNTNNITISASTQVFHLKTQNETDRKNWINVLEQARHQAICQAESEDDDLAIGSIECDFKPAIENFYKKLNDKINSVKKYEAKLIKHSEALLQSLNSLDSESDRKKISCKVDKLKESARKMALEGESFVDEANREINKLSRAILHGQEQRKQLQTQLEALAKQHSKLEKAAQFNSQKSFASKKSSIDSAFSSSNKEHISQDIIDMDDHPNTNEYYDDDSDDDLFEDACETFNRGGTKSSRKQQEDSNLFDAKIVSKHADNNQQTHLQKVCTNTTSSSKTMNGTIRVRRTKIPEKQNKPLNLWSIMKNCIGKELSKIPMPVNFNEPISYLQRITEDLEYADLLDIASEKDSLEQLAYLAAFASSCYSSTGNRTTKPFNPLLGETFEFDRTDDLGWRSITEQVSHHPPAAAHYAEGSNWEMYQDFLLTSKFRGKYLSVQPIGATHIIFKNSDNHYTFKKVTTTVHNIIVGKLWIDNHGDMTIENHKTGDTCILKFHTYSYFSREPPRKVTGFVKDKKGYVHWYISGYWDKYIDIAKVTKQPKSKDTSNGTIPIMETGEMRRIWSINEPLENSEKMYNFSQLTVALNEEEDGVAPTDSRLRPDQRLMENGDWDEANKVKNLLEEKQRGVRRKREAEAQRAMQLGEPYKEYEPLWFEKAQDPYTGSVIHLFKHEYWKCKENQDWSKCPEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK66</accession>
    <name>A0A0N5BK66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRICHOS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK66"/>
    <dbReference type="WBParaSite" id="SPAL_0000633100.1">
        <property type="protein sequence ID" value="SPAL_0000633100.1"/>
        <property type="gene ID" value="SPAL_0000633100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000633100.1"/>
        </source>
    </evidence>
    <sequence length="810" mass="89886" checksum="919A3B5A915D45AE" modified="2015-12-09" version="1">MKSVPQLEAEPRGATAQLSLVGDPLTDNLNRNNNWKNYSTVTTATGYDRTIRFGIPSQSSNVNPHSMSHDIDHGSNPNLSRQTSVSHISNASYSGNPNPSQTTSYINNNYSNGVKSQPSQGPRIQQQQPQYSPYPATSIASTAIHHPQREVKIKTPSVSTDERDRSKSIHSVHSSTQPFSSNHSKNSKDSLTSNVPKRNRLQEFLGFLRRNQRACCGICCFLFVIAIIVAVVLCAVLIPSYQREFSFQWAPPLSLRSSGIVEATSIKLTIDDSNDQARFDMSGRVPFKGNYVTVYDFKTKKAIIYDPLLKNGSRTLYCFVMSFGSDKLKDISELRKAAHNSQSLTSQTTGWEEQWHYVPQNVNNVLQVSYVNPGIPECNGARLVELKSVGSNQKNLKCTDCFDFCLPEYGIENDLIQSQSKLNILNRMCFYFFVPEWQTFAQGYNTNNVNPNLNNPQFSSYQFNGNVQNIPYSTNPQMGSNYGNGQFVGNPQNNQFNGNQNSQRYGGQGYNGNIGQFGVNSQLYPNQQQQFNNGNGQSSNYNNGMGGGSIGTPYYNNQQNNNPQNGLYNQYNPQQNGQTNIVTRNNINNTHPESKWISVNPNSIVEQITNTTSNIWSGAKETFNAGVNQAQGIQETLGRGIQNVGSGFQRFGSNIETGISDMRQTISSGIDSAGQGLQNFGQNARTNLQSFGQSVGQGVSDGMDNLQSGVADIHQQMRQQFNQMKQQNSVGPSYNTQSSENNDHNTVQYLLRNQYSGQNPQNNGNYLPNSQFDSPSQSMNNFNNNNNNLSPGMAQYSQSNHNLKNPLAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKT5</accession>
    <name>A0A0N5BKT5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKT5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKT5"/>
    <dbReference type="WBParaSite" id="SPAL_0000654000.1">
        <property type="protein sequence ID" value="SPAL_0000654000.1"/>
        <property type="gene ID" value="SPAL_0000654000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000654000.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="90356" checksum="1E100A27D5F0CE1E" modified="2015-12-09" version="1">MNVERLMIDLDVSQLEKIQEDLTKETNGKKEELRQMVGRRYRDVLDASNTLKLLTDISNKFCNKLSETESYFKSSNSEQCEKFGYDNDKIMKAKFSSKFLAFTSLIPKLPLGDGLSNVYLLLLLEKIYNHLIVEKSVFTSKDVEDVLNESKKRIDNERENVFSKLSDDLGTNQNIKFCCNQLLAIGLLSVTTLDDYKEHFFNSKLESIKQSAATGENITEIVRQIHITIKAYLQIFGHDGFIYSLTSEIKNPNWRPKIVNEIMNDQLYSVTQYLDSLIVNINNSVNIVDRGECSNEEFKKEFEQFITRLSVEVKPLLSERCQSFIDSEGIVDFMQNLVDNLISDFSKITSPKYIYYSLFENNLKQRFYQVMEEELYKFSEKFLEKTKDINLKPQNLFTKWKAKFDELVTTGVSHDLNETIEEFFIYIQSIKNNVNKYSAIDIDDNSSQIYEVFSSHVLGMIQNLCKTLLSIDNCEVDINSIPENSSITDIDFWLDRFRILLGIIQHEPPTLSECMGDDFRKIRECNNILIKSTESCLCIFLNYSIVHIECESGLLVMIQKSKSPMEWLESLQKFEDVSIGESGKIKVPVSLNIYIYNFLSKITYFLNEKGFGHLLTRGTTSHLNKIIGDIILLRMEECIRVCSSSMIILLQLLLDSKILFTMFLNEKFLSVISKIESRINPIDLELASEQITKNSSLFIQKTYMLFGLLQIEQTQGKDVMKSTQGQINITELYPRFEDVDFLPSLPRYTKSKKETSRIRDPEPVDQNIRLVEKFYSFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL86</accession>
    <name>A0A0N5BL86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL86"/>
    <dbReference type="WBParaSite" id="SPAL_0000668650.1">
        <property type="protein sequence ID" value="SPAL_0000668650.1"/>
        <property type="gene ID" value="SPAL_0000668650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000668650.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13221" checksum="F3BFFF01282C9C43" modified="2015-12-09" version="1">MFVILHLDQKLDSFNEYNASDVKTYGYQYDFYSRLHIFPTIFSIREFGQAVGLSFNDHKILFKWYCKLNFLLRLQYRKKCENDGYYDLRPGSNCVCPSGCAGEFCDKLIIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLE1</accession>
    <name>A0A0N5BLE1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLE1"/>
    <dbReference type="STRING" id="174720.A0A0N5BLE1"/>
    <dbReference type="WBParaSite" id="SPAL_0000673900.1">
        <property type="protein sequence ID" value="SPAL_0000673900.1"/>
        <property type="gene ID" value="SPAL_0000673900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000007">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000673900.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34770" checksum="C176D574B5CB326B" modified="2015-12-09" version="1">MPNQQRRQPTNSSRHPLSSNNIPSREERYRHHYRYYPYHETEISCCMKYSVFGFNVSFWILGFALLAIGIWAQIEKTNPYTQLNRLSKFYLDPSMILIIVGAIIFLIGFSGCVGALRENTCLLALYSTILGLILIAELSLAMFVYVSRDYIEGEYKLKLDDMIKMYRDDPDLQTVIDWMQQDFQCCGINGADDWDLNIYFNASATNLKSEEAGGVPFSCCVHSSDHGLTNYACGHGARLNKQNLVKAIYIEGCLPKLQLWLANNFIYSGTFLVIISVTQIMGILFAQCLRADIFAQRDKLMRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM07</accession>
    <name>A0A0N5BM07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM07"/>
    <dbReference type="STRING" id="174720.A0A0N5BM07"/>
    <dbReference type="WBParaSite" id="SPAL_0000695300.1">
        <property type="protein sequence ID" value="SPAL_0000695300.1"/>
        <property type="gene ID" value="SPAL_0000695300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000695300.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23240" checksum="4FDC88314FF65BC7" modified="2015-12-09" version="1">MMENFHFDNTIRFVKLRAPVQNIEQMESMIFKFTESLGHRSQIETVYFNSFNGVLKIRQYKNADNYGELISYAKLPCNSRKCVGEMKYATLDNCLETTSVLSLALGEKTGINILRRQFEKDCIIINLDHVEGLGHFMSLKYILDKSKDISDEDAFKTITDIMSKHFNYTKKDLLPVSTYADLLKCNGLPDSDYDEDHTSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNZ2</accession>
    <name>A0A0N5BNZ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNZ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000762100.1">
        <property type="protein sequence ID" value="SPAL_0000762100.1"/>
        <property type="gene ID" value="SPAL_0000762100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000762100.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18716" checksum="C623AE16D613072F" modified="2015-12-09" version="1">MKSDDIRKHILKYILNVSDIENMAETCRSLYWLISEDKIGRDIMWLDDDHDLTIKFKWGLKNAFELPLLERVNMPKENYGCTKLEEQSRYYGETIINGNGIFFKIKSSIETYIPEESIYLAQKMAEELMINHQSRRDVETLHLKMNATVSNVHYYLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPJ9</accession>
    <name>A0A0N5BPJ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spc7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPJ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BPJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000782300.1">
        <property type="protein sequence ID" value="SPAL_0000782300.1"/>
        <property type="gene ID" value="SPAL_0000782300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000782300.1"/>
        </source>
    </evidence>
    <sequence length="803" mass="90054" checksum="7D0CF26C47C27E07" modified="2015-12-09" version="1">MSDRKNSILKQTNDGSSSSLGTPENSVKRRVSFSSKRVVQRFDKTDLTVRFDTLMEEEIECSALSGSLNPTKAPMSNGRPMTACGSPENSALEGLNTTFDVLATSPGNISFVSTRTPNTPAMNTTRCVFGPFGTNTPHIEVLNDSETNDDMDISFARTPMKAHTENSTLAVANNNIVNMSVTSPEELAFEKENNISMGENNFSVSRDTSNAHQSSNNNKASTSYKILPNSYIYRNSPAYVFGGSDSGTTDISDHSTPFRRRSLNSTRSGRSNGLRRSLLEDMSFSVEGVTTSPDKENLSNVYDVDNIDETNLSQSFIRLASPARTSEVPEFTQISPIANDFVNDNSLINASVLGSSVKRNEMEEGQGHASSFNSDQRVFNNSCNIVDKDILNVNPSTGDISRNLTTLEDKSQSFINDSKVVSALDNAPLTESFNEKNCDTMDGHSSLLSIECSEKVPLQGDQCETLYNNTTINFNKSDHCKDRTIVEKHSGTLHTILEEEETQLFDKTISIDEVVARSEELKNAYIDRLNVLESTDTASQDHESDMFNETSGFSTDPDMSIWNRSDSVAHSNMFENDCEEPGSPLFTKKVETDEQNNLSTTDVTMRTVGESFLSSEFYDITKAKEGLDFINPVTSVIYNGNYKKFDVNYQLRLAIAFVQSILYNEFLRQPMLKDFVHGFEKSAELKNFMVRAETPLNLDDLYDKVLDLEDIGEIIDDLRQVNFDVYKTAADRLEVFFDTIYDIYFLLLDHLSVYQQKQIKYNDKVCHECFRIFNEINEIKKLDDGERKSLSDLLNYIVPKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ40</accession>
    <name>A0A0N5BQ40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Voltage-dependent T-type calcium channel subunit alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ40"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ40"/>
    <dbReference type="WBParaSite" id="SPAL_0000801100.1">
        <property type="protein sequence ID" value="SPAL_0000801100.1"/>
        <property type="gene ID" value="SPAL_0000801100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008332">
        <property type="term" value="F:low voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000120">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000206">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000008">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF230">
        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="364"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="693"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000801100.1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="116773" checksum="5C1F8B0C9B85DABB" modified="2015-12-09" version="1">MDFDSFLHAIVTVFQILTQEDWNMVLFNGMAQTTPWAALYFVALMTFGNYVLFNLLVAILVEGFQESKEEEKRQLEEEARKRAEEEEKERNKELELLIAKTTSLNFMIKSNTKEAICTCSKDILNKESSNLTSKNTLVVPNSRPRAFSSSIESSKEFTSNEIEDYCSSNNNDEFTSDRKKFNDEKIYINDNNLSIKKKNTSKSQENLLTENFKDDNHEYCKKLSKTDKMYDSAKEVYFSETITFLPPINSNNDKKSNEKNVDKEMGRPRTSSWCGIHTLFNPQCPIHSRRALIEAYARDKLIQASQELQQVLVEEERKAEERKNTFCRKIYTKTCLYKRKDHSLFLFSTKNKLRINCLRLTQKKWFDYTVLIFIGINCVTLAMERPSIPPDSLERKFLTITGYIFTIIFTLEMTLKVIANGCLFGKGAYFKDGWNILDGILVIISLVNIIFEMLVHIDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGHDVSNVITKADCLSVTGNKWVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDMQPIENHNEWRMIYFISFLLLVGFFVLNMFVGVVVENFHKCKEALEAEMREKARQKRLARKLKRQQFEDHCALRKRQKEKSYPYWYNYGPARMYTHNIITSKYFDLAIAAVIGINVISMAMEFYLMPPGLRYVLKALNYFFTAVFTLEAAMKLYALGIKTFFVEKWNRLDIFIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIARVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSDDHPCDGLGEHAHFKNFGMAFLTLFRIATGDNWNGIMKDALRDDCDPSDHCDTNCCVDPILAPCFFVVFVLISQFVLVNVVVAVLMNKIDPNIDIENDNEFERKQLTVVALEKQIIDLEQKMFEDGRLEIPESVYTPQIDMNVASDSIEKIEDVNISKNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS06</accession>
    <name>A0A0N5BS06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER lumen protein-retaining receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS06"/>
    <dbReference type="STRING" id="174720.A0A0N5BS06"/>
    <dbReference type="WBParaSite" id="SPAL_0000865200.1">
        <property type="protein sequence ID" value="SPAL_0000865200.1"/>
        <property type="gene ID" value="SPAL_0000865200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000865200.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24690" checksum="3774412FB1132BEA" modified="2015-12-09" version="1">MNAFRLAGDLCHLFAIIILLFKIWKTKSVSGLSGKSLVLFALVFTTRYLDLFTTYISLYNTIMKIFFIASSYATVVFYYHMFKHTANSEQDNFRVEILVIPAAILACVINAQFTPLEVLWTFSIYLEAVAILPQMFMLQQRGEAETITAHYLFCLGLYRGLYILNWVYRYQTEQFYDPIAIVAGVVQTVLYADFFYIYFNKVIKEKAKMALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS76</accession>
    <name>A0A0N5BS76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS76"/>
    <dbReference type="WBParaSite" id="SPAL_0000872100.1">
        <property type="protein sequence ID" value="SPAL_0000872100.1"/>
        <property type="gene ID" value="SPAL_0000872100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895089" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000872100.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12210" checksum="AD68F65BECD49C49" modified="2015-12-09" version="1">MHFIKYFTILVLLAVQHSFQDDTTTYATTPAYMYSYDYGDSGFGTTQGSKSVTRKKRSSIKEKFEKMKAKAEKLAKKATDGAVKAFDKTKNAAEKMVDKANLAMRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSH5</accession>
    <name>A0A0N5BSH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSH5"/>
    <dbReference type="WBParaSite" id="SPAL_0000881800.1">
        <property type="protein sequence ID" value="SPAL_0000881800.1"/>
        <property type="gene ID" value="SPAL_0000881800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000881800.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="60247" checksum="F303DF67D46A61F1" modified="2015-12-09" version="1">MESEDSINPLNNEVESTPDQELTPAQIIANNTEILSLIFGHIVNFKERRNIELTCRKFYEVCNNKSLCSYFPLEEKSRLHFSMRHEEVDAIINIFGHKMTINIPKEFLFNENNMDIFGRFFRKYLSKVNTLIIVDMSLKHVDFFMNLNCFEKIKNVSLYSRASVNGGDVILSKCSTLNPVNLRISTGYLNDITIEKIGQYPLPDSIETIRLNYSSLKWLLGKMETKKLGSFGNLEFECDEPLSFFMNEINKKEIYLKSITYFKNISCKVYNFKTIPYIEEFNNILLENNIGLFVTIRFNDIFREIFSNEFERDSKAAEHVRNLKNPENRFLAQEGVYLNIKKLKILDIYKERCFCPFFSTELKLMTEDILRMKRLSLFEMHFSLFDNSNDFEKLCTSLGRIQTIRIHDCGKMNIRSLYVLSAYAKNLKNMSLNGVNDKSITTSIILSHFKTLDSLEIIFENLYDAVLVFNDLMEFDNASGSVTFNWPKIQHLNIICNRPNFEEEKLINEVKKNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTW8</accession>
    <name>A0A0N5BTW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000929200.1">
        <property type="protein sequence ID" value="SPAL_0000929200.1"/>
        <property type="gene ID" value="SPAL_0000929200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000929200.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18805" checksum="D91316C13904615D" modified="2015-12-09" version="1">MGSGVSKKSKSSSNKVATTTPMEKEEKVVIDKIEKIYPWPDISLGANPIYPDNHVHHLRRTLELNEKTYQSWVNAISDSEQEDKSYKTTTKVKPIKKVKKIKKKIQRTKNSVEPTKNLIQMEKYSNRYNRTFDKTNKPGPFTFTRVPTPPSKFLSSKNYQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTX3</accession>
    <name>A0A0N5BTX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTX3"/>
    <dbReference type="WBParaSite" id="SPAL_0000929700.1">
        <property type="protein sequence ID" value="SPAL_0000929700.1"/>
        <property type="gene ID" value="SPAL_0000929700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000929700.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16706" checksum="C9B975D5426A4940" modified="2015-12-09" version="1">MVLINPSLIIIRIKFGTTVMVVVFSKIILDTPKNISIFGHNPLRISNRLCALAQYRSELMNEDNKLLPDRDKQSNEIIFYTPYGYGMYAIKILFDDTYFSHKKLNRKAAEVGNRFAGLLSYDQQYVGFGLSRSASGTYACIKHSSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUD4</accession>
    <name>A0A0N5BUD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BUD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000945500.1">
        <property type="protein sequence ID" value="SPAL_0000945500.1"/>
        <property type="gene ID" value="SPAL_0000945500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="708"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000945500.1"/>
        </source>
    </evidence>
    <sequence length="1494" mass="172766" checksum="98E53E64C7B36AFB" modified="2015-12-09" version="1">MDDTTTISDMEVSLNSQPKSSSPSAGKSRTNKRVSIQFDPNRSIIAAGVSERLLNQPGLENVKLYIEEVKSAYDNAAIQNKETLEKLDKLKKKFTEVKNAYEKENLQLKNSIRMSDCSRVELTQEIKLLKRHLSLKDQCDSEVKQKLDETLELYDKLKEEMEEIEEENSRLKDTVVLLDSYDMKIKEYVDMVSILVQDKEILELRLVGLQKELQKQVQMSSTSKDMELDVYLCKAKLRQVEKRYNNILKNLENTKTEKESLENNVKQLRDTIYALEIDLKFFQDQVIDQVKEIEKQQNQLKKFELENKNLNITINDMKEEFTDRERAYLVNESVLQEKLSAMTTENKEYIERIAQEYKSEKERLLQKHKEEIELLNKEHEKAIAEIYKKEETKIDAMKKQFNEQLDIVAIAATSRSEDKIKELKNQVKEHEITVNNLKHENRGILEEKHKIESELKDAEEIYTQTLQEKISECSELSKTLSHTKDELNRYDLCMRKLEKDNADYKTRIETIFEPKIDSLTEQNRKLEEQFIEKYTLCNILQAQLEEKIREIEILKVQKNNTFQQGSQNVEVQGVSPTTDQLLHELSEYKRYALELQESYNSLKANFDSQVQIINDGKLYTDFITKKLEEKDLIIRGLEDKIKEVGIISKNIVDTELIQKQTSINNCRKMDNKNTLVCKNCEKLAKDISILDHKAQDLISQINFMQTQINGLNIQANSYSDKIEQLEQQIEVYEDERLEHETKENDMKERIKKLEYDNKKISKEINCLKEQLCKVNQELIIKDQELSRHHEQLLKLEIEKEKLKREKFEQHLNDGQSNGDSMISKEVYETILSDSEMLINDLREFVDRVSVTLESLMNRPFPTLPEVDYPSMINIAKAVVQLIELIPSKEINDNTISNAISPHIDELNNKIRHLEDRLCENNRSWESFYKIEHDCRMSFEEKLKAAEEQINRLTMQLLEEKGIEEIQKTVAESAMTIIPPELLSSVPIGIKMKISILAAKLSTKMLDNDALLRANKEIADTNVLLQNRVDYYKEKLESIENNCKNNPLSNTFVSSDIENCKGVEKETFKNSNDLIEDIFDSQVDVPLISNTESLSSTGSIADICSNNEKQNVGTDDESEELCNKSNMDLVSLQTENEEVYYAVTFEKVNDIMLEASINNIDKFSEKDVLSISTVDAKFLKKDEKSDSTMTFDLKIEENEVMTLKVPISLVTSFSIEEKNENVTSDEGTDGSEVFNEISKDVKPTEEIKKIKSIDNQDFSNSTKIDIDDKEKLKNKMFNSEKNLDENNTYHNPVSKEYETMAIESKKSRSKINDQVTLTPKGGSIKEVTKKPPIVKKVVSNTIELFDPFEIPKLPQRDEDNIFDEIFAQDSKVDLPTITTKKKSTLNVEKKKTIKKALIGNDIFTNFNLPDIITTPVSTVPKGNKVNLSSSNSKGAFVAPDKVSLNREYTVPKQSSDVLLHHRSETPKDFVPVDFKKEPPKSILKPRALSKPKYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUI9</accession>
    <name>A0A0N5BUI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000950900.1">
        <property type="protein sequence ID" value="SPAL_0000950900.1"/>
        <property type="gene ID" value="SPAL_0000950900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000950900.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32562" checksum="093163C62DC828F6" modified="2015-12-09" version="1">MTFNFTCYVCLDQMNPNNMIAISCGHVLCGSCYDTMYIRRGEERICGLCRHRFGSGLKLFLDEGTTKTNEITYQGTSTNDYLNLEKIKKLEKDLETEKCITESLEFELKEKQLEIIEQKTIALALQREIEDNHEKINRLSKKISEIEIKPVTKKVVNDPEYLWLSNDPDEDKTKFHYKQEHDNKKNDIKISNNKFNNEKKRFNEVKNNEKNSYDNIRYLKELLNEKEKKLESVMKDKSNLQQVIEDLKKENKILHSNNDVLEKELIRKGKTTRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUK8</accession>
    <name>A0A0N5BUK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein K</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUK8"/>
    <dbReference type="STRING" id="174720.A0A0N5BUK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000952900.1">
        <property type="protein sequence ID" value="SPAL_0000952900.1"/>
        <property type="gene ID" value="SPAL_0000952900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22433">
        <property type="entry name" value="KH-I_HNRNPK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="275"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="468"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000952900.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61543" checksum="7B2F09DDF48748B9" modified="2015-12-09" version="1">MYQEPTPKVEAPVSPDMKRRSPTNVLSNELIDSINAESEIPVNQAKRTKQDDENLLDANDQQQTPSIVIKQNIKEEEIEPKIEDTTIESQVHFNIGINQNNGIVNDISSGDRDNQKDIKEEFGNQQQEDLEVKEEEDSNQKTSDMGEKLQVGSENSPTSQQHQQEDQNEEQKDDQQHDASVTTTTPGGGNENSGKGSNSKYEIRLLLATRMAGAVIGRQGSVIKNLRTEYNANITIPDKKMPERVLTISASFDNIMKIFDVVLPRILEEQRNTTDDNEIRMIVHQSQAGAIIGRGGSKVKELREKSHAYLKVYTDFCPRSTDRVIQITGNQEKIRTAVSLIIDYLKTIPIKGNIQNYDASNYNPSHINSYGGYPGPMMGRDILPPYQLPHGRGIPIHSRGPERSYYDPGYSYNGPPMYNCNTKRSGGSGGGGFQGPPPQYNRPPPMDYVGISRSGGIPPPPPGGQDFTIQTNQVSIPNNYCGLVIGKEGSKIKQIRQKSGAKIDVEPSNGSLDRIITIQGTYSQIQMAQYLLQSCIKNQESTGAKRTYGGQRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUL0</accession>
    <name>A0A0N5BUL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUL0"/>
    <dbReference type="WBParaSite" id="SPAL_0000953100.1">
        <property type="protein sequence ID" value="SPAL_0000953100.1"/>
        <property type="gene ID" value="SPAL_0000953100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000953100.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="26548" checksum="52CE60740D6BF113" modified="2015-12-09" version="1">MTAKLRQHSLSSVRKLQELLHDCNLQLAAYRNAVQGIGTSADGVALRKEIDACARACVRSCESTKNCVLPQLRHDGELSVEFTKHASQFIGCVSACVVEMKRCTAMEATFPITNFAGNTSAGPSTSGTGVPSGTPTVVPTTSGQTPSNPEISGQNNSGVPGGITTNTTGNGNGGATTSGTGTSSSIIQQIVPTTSEQHIIEMEQMLETLENLITVHFSTTETNPTDKVTPRRRRGASCRPQCVCSKLKTSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUL2</accession>
    <name>A0A0N5BUL2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BUL2"/>
    <dbReference type="WBParaSite" id="SPAL_0000953300.1">
        <property type="protein sequence ID" value="SPAL_0000953300.1"/>
        <property type="gene ID" value="SPAL_0000953300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="388"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000953300.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54906" checksum="8150FF4C5FDCC321" modified="2015-12-09" version="1">MSTNESTRVNQPITKDKASTIRNYSTKPRLVYKTVSGVNGPLVILSDVKFPQYSEIVYLTLADGTKRMGQVLEVTKKKAIVQVFEGTSGIDAKNTVCEFTGDILRMPVSEDMLGRIFNGSGKPIDKGPPVMAEDFLDINGQPINPHCRTYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNDIAAQIVRQSGLVQLPGKDTSQQSFAIVFAAMGVNMETARFFKQDFEENGSMDNVCLFLNLANDPTIERIITPKIALTTAEFLAYQCDKHVLVVLTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLSTIYERAGRVEGRVGSVTQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTREDHADVSNQLYACYAIGKDVQAMKAVVGEEALSADDLLYLEFLNKFEKTFISQGNYENRTIFESLDIGWQLLRIFPRELLKRIPVSTLDKYYRRQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV44</accession>
    <name>A0A0N5BV44_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="STRING" id="174720.A0A0N5BV44"/>
    <dbReference type="WBParaSite" id="SPAL_0000971000.3">
        <property type="protein sequence ID" value="SPAL_0000971000.3"/>
        <property type="gene ID" value="SPAL_0000971000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17100">
        <property type="entry name" value="FERM_F1_PTPN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06706">
        <property type="entry name" value="PDZ_PTPN3-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14541">
        <property type="entry name" value="PTPc-N3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF4">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="31"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="908"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="1217"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="808"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="669"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="723"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="833"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000971000.3"/>
        </source>
    </evidence>
    <sequence length="1317" mass="149502" checksum="98940B75EDD04624" modified="2015-12-09" version="1">MRFGTGSYNVRHSEGLNPDTLRNTSNTKQTLSCTVYFLDDTERSFTIGKGSIGQEILDKVFEHLELVERDFFGLQFLSFLDSQAEHPRMRWLDPQKSIKKQMVCPPFHLYFRVKFYVSDPSKLAEEYTRYHFFLQVKRDLLEGRLLCPESSAALLASYAIQSEMGDYNINDNEYIDNFKIIPNQPCDLSKQIKELYKLHSGQTPAIAEYNFLDHAKRLDMYGVDLYEAHIEEGIQILVGVNSYGICLFQNGQKINAYPWCSIMKLTFKKKVFNVVIRILNELNEEEDKAFFFHIITSQSCKLLWKSCIEHHTFFRLIAPPIPPPKSIFSLGSRYRYSGRTEFQTMEEMKRRARVERAFLRANSRNNFGRATITGVGVRNCPSTCQQNSLEQANERDFNSFEATFDDADGGEYNLKGNNSIYSFEKYDNDYIENSKNMNSITSYTSWVAKMFPSTQWKKKQCQLRKNFTLNKSLRINNNDSSTSNSSITSFFNKLFPKLESNRNNIAGRDDYVGNDCLKMLNHRKVDEFDGLNYKQSGKSESVAPSPSNTLNRKVPNIKTHYSPVKIQEIENNSNMAATKQQLYDDKKISLRQNINQQYNKNALDDRLRRVSQGRETTFSASGNDEDGIRYCSGNWTVPQHNENYDSGFSNSSNGCGYYQQSINTGNDASLPSTLNNSITSSSSSRSPIHNSSINTKNCQNNSITTMHQNNNSTGNNYKKPNVSSNSSSTASSTSSAYGTAGSYSSNNSHHNNIMYTNPSNSSISNHTLTRSSNNTPRINNSSTNPSNSSPYKNSPRIQQQSGIVLNQMNGYSPRSSVASYSSYTSSNGLPSTNNQSYGGSGSNGSNNNHISNGTLTSNKSISKNLSSSSPVRQVSSLSQRRSPSSGIKPINCSLANNYFSNPEDNLVTIRMRPDIQGKFGFNVKGGSDQDHPVIVSKVASGSSADKCYPRLNEGDQVIMINGEDVTHWTHDQVVRFIRSAKDTPTGELILNIKPNVYRYGEHEEPTSFNVPEVKHVADNIPKKDMLKQSLRILQENLRNGMCVEQFETLYRKNPEMTMFDSKSSCNVTKNRYRDILPYDETRVRLQKSVSGDYINASHVNIEIPSSGIINRYIACQGPLPTTCGDFWQMVWEQSCSTIVMLTTTIENDRVKCHQYWPRLHDSQDYGRLIVTCIKERETPHCAYREMSIKDIQTKEERRVSQMQYTSWPDHGVPEDSKHFLDFVEEVRKTRHGSVNPMVVHCSAGIGRTGVLILMETAACKIEANEPIYPIEIVRKMRDQRAMLIQTTEQYIFVCDSILKAYDHGILKPISEFHKSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVA1</accession>
    <name>A0A0N5BVA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVA1"/>
    <dbReference type="STRING" id="174720.A0A0N5BVA1"/>
    <dbReference type="WBParaSite" id="SPAL_0000976600.1">
        <property type="protein sequence ID" value="SPAL_0000976600.1"/>
        <property type="gene ID" value="SPAL_0000976600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894902" evidence="1">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="167"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000976600.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32451" checksum="81B65E301C1FBD68" modified="2015-12-09" version="1">MNFYLLIFLLFFQEISSAPCPQTPGFLLAPNDKCFKIFHGRHGYKKVHESCSQQGGILSGFVTDIETHGFNIIMGKHFRKIKEKYVDRGFTCHNKYDPCTMNSNHNETVTNKIEFLTDNFPCRGVMDIKKRTFHCVDMNYEENIIYACQKNSPHIKKCSNLDYEKYTDGNCYRIIGDFAVSKITAKAICKGASGTLPIVSNYFESHVIDELMKKIQHPTWLDFSCETSDASSCKWSTGEKMQVNHIGHFNLKDKNLCGYIGEVNSWSADHCDTQKRVICQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVP3</accession>
    <name>A0A0N5BVP3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Long chain base biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serine-palmitoyl-CoA transferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000989900.1">
        <property type="protein sequence ID" value="SPAL_0000989900.1"/>
        <property type="gene ID" value="SPAL_0000989900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000049">
        <property type="entry name" value="serine palmitoyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="99"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000989900.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53512" checksum="63F7974970583011" modified="2015-12-09" version="1">MKSIQADESTFADIIYTFFQSHYAIETLLLGIIVYMLLFRKKAPKKEIAPTLSDEEIEQYINEWEPEPLVPETPNDHPALNPRFIEGKMGKYIKIDNKEYINMATNNFLSFVGDKRIEDVAKKTISKYGVGSCGPRGFYGSVDVHLDLEKDLAQFLKTEETVLYSYGFATISSAIPAYAKSGDIIFVDKAVNYAIQKGIQASRSRVEWFDHNDMNDLERLLKAQEVLDKKDPKKAEKIRRFIVVEGLYSSTADICPLPEILKLKWKYKVRVFIDESMSFGVLGKAGRGITEHFNVDIIEVDMIMASLENAFASTGGFCAGRSYVVGHQRLSGLGYCFSASLPPLLATAVSEELKIIQSEPEKLQLLKANSKTLFKGLKMIFDGTEFSIKGSDLSPFLHILYNGKQSDADKKLDNLVDSLFCESIIVTRTRYLDKDEKFHQDKSIKVTVSSDFSENDMVNILNTFKKALNNCKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVT3</accession>
    <name>A0A0N5BVT3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVT3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVT3"/>
    <dbReference type="WBParaSite" id="SPAL_0000993900.1">
        <property type="protein sequence ID" value="SPAL_0000993900.1"/>
        <property type="gene ID" value="SPAL_0000993900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="7">
        <location>
            <begin position="404"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000993900.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="82347" checksum="6D1FC77E5F264AA4" modified="2015-12-09" version="1">MTVVLNINVNANEKNSKEPLENKYADPEGFIDEEPAIRAREELADKMPKKNKYEERCVVVFGIPVIGSERVQKLSNVLKKIISSTSDEFEETIPLSPEGGTKGLLFIEYPNKDIATKAADLLNGYVLDKNHTFKAMTVTTSRSIQKPDPNWKKPEVREYVDAGNVYSHLTHKKCLDQFGVQYCGSRERDAAQLGVYWFQREQEPVLADSEANRANWSELPFRWSPKGTYITTLHSLGVQIWGGPTFNRIQRFSHPQPIFVDFSPQEKFIVVFSYPFSSSQGSKSNSVCCTIFNIMSGDVVKQFTALQLGLTREDPKPTWPIFKWSHDDKYCGYVKRKSDSAILFNTDDFSTSDTLPLSNVSKIEWSPINNRIAYYCQENIKTSAPAEIGIMSYPSKDKLRAARVFNCSKAELFWHTSGRYFAVISERYGKRTVKDNEVKYFNIVTHVDIFDCSVKDIPLLNLTIDDQFKSFAWDPSSDKFAILCGTSIKTTSFIYNVEKTKHVPTLLLKLDEPSIHNTLKFSPFGSWLVIAGCKNIGGGSLIFLDCSTNEPSKMKTTDHSDMTSCKWDPTGRYFVSICSKPRSDNGYVIYNFQGKVLYKAQHDILIRFDWRPRLKLDGHENRVAEVKKNFKKFTSQFDEEDRIEKDAVYRDIVVKRREIYEDFKKIREAYLKQYALEAPIRKELRNGIDTDKLFENCEYVNQEVTVVVRSSETSEPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW12</accession>
    <name>A0A0N5BW12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW12"/>
    <dbReference type="WBParaSite" id="SPAL_0001001800.1">
        <property type="protein sequence ID" value="SPAL_0001001800.1"/>
        <property type="gene ID" value="SPAL_0001001800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431:SF3">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431">
        <property type="entry name" value="PROTEIN CBG06927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001001800.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40865" checksum="230AF24C8783D703" modified="2015-12-09" version="1">MKLYNLFILYKYNWIKFLYFIITLFPIRNVVSEKVLHDFCPNIYSEQIQNCVLPVSQYAKILHQQNGKSMDTEFNQAFSIPKVGKEVFHELCRLIRNFDTCIFKLRKQCPNHITINLIDASYGYLCNEAYDVFLNSAECLMELDLQPNIKECHDETLKEIEAISGTSAITLHLKLDRMCNALNFFSSCVRNPIKEKCGNDAWHVIYQVLKYTTKTLMPGCTFNSNYHTQKHHVKNIHTHENINNNNHNIEKQNVELDNNNKNVVTNYTMNDSRMKNSNDETSLETTHRKNIEDGIKNSKASVNNILNKNLMTNHKKSQKENLYQNKNISSYKNTNIISNLIITIFIIFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXC8</accession>
    <name>A0A0N5BXC8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXC8"/>
    <dbReference type="STRING" id="174720.A0A0N5BXC8"/>
    <dbReference type="WBParaSite" id="SPAL_0001045900.1">
        <property type="protein sequence ID" value="SPAL_0001045900.1"/>
        <property type="gene ID" value="SPAL_0001045900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001045900.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47610" checksum="5D785A1FAC67ADD4" modified="2015-12-09" version="1">MAKIDSCRKNLYVHFTGGFLSLSVIFIILLEFCNTNESIPEEYMSTTQIIEYYKYPSETVRVRSDDGYVLEMHRIPHGRMNFNDTKTTRPVIFLQHGLLASSSDWVMNEPSQSPGFVFADAGFDVWMGNMRGNVYSREHEKYSTYSRRFWRFSWDEMAKYDLDAMINYILDVTGQESLYYVGHSQGTTTMFSKLSEDEMFRKKIKKMFALAPVGQVGHIKGLMYTISELFKSHINLFEKYFGSMEFLPSSWYLKMASRLFCSGKLTNPLCQNVMFLIGGPESNQLNVTRLTVYLSHTPAGTSTDNIAHWAQMVISKKVQKFDFGSPNKNLLHYNQTIPPSYNFSNIFNDVYLYWSESDWLADGIDIKEGILNVLPNIKLSKCLVDFNHFDFIYGLRARVEIYDNIIEIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYG0</accession>
    <name>A0A0N5BYG0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BYG0"/>
    <dbReference type="WBParaSite" id="SPAL_0001081600.1">
        <property type="protein sequence ID" value="SPAL_0001081600.1"/>
        <property type="gene ID" value="SPAL_0001081600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895050" evidence="4">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001081600.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31352" checksum="D6D0C6A14AB5997F" modified="2015-12-09" version="1">MKFVKFSIILLVLTVSVTHGQDNDFMNKAIQNMKERFGQVKVRLPDFIVTKVEEPDNATLTXRTCRQNMTYTECGGCERTCLNREMACTMMCRPPGCYCNSGYLLNEHGSCILESDCPQPESAEPVDPPAVIVDDSKTCPKNYTYLECGTCNDKCGGPVMCTRECKKPGCYCVVTASLDNDNNCILKSDCPNEDPKNKLPRSKMIIKILGKRPRRCKDTPIPTRKCKKNETWNKCGNRCEGTCKKEDKMCIEICGPGACVCSTGFLRNDDGVCVPKDNCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYX7</accession>
    <name>A0A0N5BYX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYX7"/>
    <dbReference type="WBParaSite" id="SPAL_0001097600.1">
        <property type="protein sequence ID" value="SPAL_0001097600.1"/>
        <property type="gene ID" value="SPAL_0001097600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001097600.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="62923" checksum="32E0D8D9CC1CA7FA" modified="2015-12-09" version="1">MDNIDEKDILFGLLNINLVRKTITNHIPSFSDINNLVDVCKFMNHDLEKEKIERSIFSYGDCQNIRITCNEEYDEDSGVPELSDIEFREDILSEDLLNRSRTFFGETLHNGNCVSYFIDPSIKEWKEEDHVGFMKKLTEELNLKCTTRKDINSLEFQFGFRNNAGYIILDALSHMKHDNITRISLPVGCFTSPSNKYNMIDGNIFSGFPNLSELSLTCPSPHSNYYDLIHHKDTFERFVQQFSTVKNPTIFFKSLKHNDTMCPNNLNEIINTITKYSVKVKLGIDIDCPRFGGQCENCTDTIGFFSPIKQYITTAYSTVRYHKQLLHSIGILETFKNLSALHLRFTLDDINFNFLASDGQKPGDLGFKNLNSLKSVKLEYSRNLNDHDSSVLNLFYQFFELTCSMMPRNVEILQLEHVPDMDDATAKMITRYMPNIKLLKIQCLSYKESDGLDNFSKLECLISYDYCPIRIPKTLKVLAFEHRKYTVRRDDLVFTDNVIKSHYEEFTKRISDNENRFILFKDICQWNSYKYAIQEYFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ07</accession>
    <name>A0A0N5BZ07_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ07"/>
    <dbReference type="WBParaSite" id="SPAL_0001100300.1">
        <property type="protein sequence ID" value="SPAL_0001100300.1"/>
        <property type="gene ID" value="SPAL_0001100300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001100300.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14057" checksum="A32F08EE7885F394" modified="2015-12-09" version="1">XLQNTIKNSGYAKPRKIQAFAIPIIANGFDLICQSEAASGKTGTYLLPIIDEMLKNEWKSKNKPKTPYGMIIAPTRELVIQISEYGRKLCEGTKLCCAMLYGQKTKDFFKHIKSNSSSTIHMMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZT8</accession>
    <name>A0A0N5BZT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZT8"/>
    <dbReference type="WBParaSite" id="SPAL_0001127800.1">
        <property type="protein sequence ID" value="SPAL_0001127800.1"/>
        <property type="gene ID" value="SPAL_0001127800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001127800.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13648" checksum="6F7686889BAEA0A8" modified="2015-12-09" version="1">MIELLPEYDSPVAAEDCSPSGVGVVNVFLQKYFSQKITMKLSSRIALLAIFVAIIMACLVTYGNAENATIINTTGRYNQNSTTTTSTTAKPTPTPEGEQSSAATGLSYSGSNSIILSAFCAISIILGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0A4</accession>
    <name>A0A0N5C0A4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0A4"/>
    <dbReference type="WBParaSite" id="SPAL_0001143300.1">
        <property type="protein sequence ID" value="SPAL_0001143300.1"/>
        <property type="gene ID" value="SPAL_0001143300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="485"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001143300.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="82574" checksum="55A5E53DCC8D493A" modified="2015-12-09" version="1">XASKIDLTNSFFQISLHKNNRHHFSFTAFNQTYQFCRLVQGARNSPALFQRSIEQLIPNIENAQIFTYIDDLLILTNSTPEHHYESTLQVISSLDARGLKINISKCEFFRDSITYLGWTFKGATYEPAVDSVYALMKKSRPTTKKQLYSRLQSINYFRMMSPLFTKYSKRLHSLATSKSSKDLVEWSPELIDDYDNLLKCVFASPLHLMPTNEPYTLKIKVDACQTGIGSSLIYVTQSCDIPKPIAHYSFKLPVTKKDRSPTYLELLGIKKSLDYFHFFIVNANSTVIVESDHRPLQFIHKSSEKHLTDLIQCICAYDIKITYVNQSSNQLADSISRLFSSNNVILKKRGRPKKVQFLHGEVDQFDSLDIHVLELQSNEKSLLDAVENNTPWEGVHVKRRGDDVIVTSTNQIVIPENIETINKILFLSHDKSDHYGIERTLQTILASTFIPHVRKYVSDYLANCSICQSTNPAPSKPVDSNCNYNFHFPWQNVACDILGPLKETSKKNKHIILFTDIVTKYRIAAPLPDTTSSTIMNVITTIIQTHGPMKLLRMDNAPYFKGIEKSLSEIGIMSSFITPLNSSGNAFAERHIECLQHTLTKEMLSQSGKEWDDLVGLIVYYYNISSKQNQPSPYELHFSRLPVSPLSLRLKASSFINNKEKEMTNLPSTKTAYYKKKSTRKLEPKYSDPCQLQSISNDKKTALLITHDGRKLRRSSRNLKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1A1</accession>
    <name>A0A0N5C1A1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1A1"/>
    <dbReference type="STRING" id="174720.A0A0N5C1A1"/>
    <dbReference type="WBParaSite" id="SPAL_0001177825.1">
        <property type="protein sequence ID" value="SPAL_0001177825.1"/>
        <property type="gene ID" value="SPAL_0001177825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001177825.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="31276" checksum="4827D586C280401B" modified="2015-12-09" version="1">MNNQYVIFCINLLYEIPSFILLVIIEIILLIPSNRKIFYSSFFKIIFFNGLFDILSFVTFTIHHRLPNYGILVEFYNDLFMKEVDVRSVEFLRSLSTIGQLIGMFFLCFNRFTSVYFQVRYDNIWRYLLPVYYVTVTVLPILLTFPILLDKMIYKPFDRSNISFGFKGRWMTYNARWYNSYMVTSILNLLFLTLCAIINFSTLFLLIRYKRSAESKVQDVGSNHTMNFSMEKKFFLLAVVCFTGQLIFALSGVSYNLIILLFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Y6</accession>
    <name>A0A0N5C1Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Y6"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001200400.1">
        <property type="protein sequence ID" value="SPAL_0001200400.1"/>
        <property type="gene ID" value="SPAL_0001200400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001200400.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13249" checksum="91494C332F98DA4B" modified="2015-12-09" version="1">MLQLPMFSDCVIEVQGLQIKVHKCTLAGRSEVFKSLLTEEGCKSSPNIIKINDFRPEVAKEMVNYLYTGKPPNMNKMTLEIFDIGRKYGLEQLKSMAEDILFRSLSIENVYYYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2D3</accession>
    <name>A0A0N5C2D3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein kinase C</fullName>
            <ecNumber evidence="20">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interaction with par-3 required for the peripheral localization of par-6 and to form a par-3/par-6/pkc-3 complex, which is activated when cdc-42 interacts with par-6. Binds avidly to the phosphotyrosine interaction domain (PID) of a novel pkc-3 adapter protein num-1, which enables tethering and targeting of pkc-3 to the cell periphery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2D3"/>
    <dbReference type="STRING" id="174720.A0A0N5C2D3"/>
    <dbReference type="WBParaSite" id="SPAL_0001214300.1">
        <property type="protein sequence ID" value="SPAL_0001214300.1"/>
        <property type="gene ID" value="SPAL_0001214300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007506">
        <property type="term" value="P:gonadal mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000071">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012233">
        <property type="entry name" value="PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000554">
        <property type="entry name" value="PKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15" id="KW-0278">Fertilization</keyword>
    <keyword evidence="14" id="KW-0306">Gastrulation</keyword>
    <keyword evidence="12" id="KW-0334">Gonadal differentiation</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="27">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="25">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="244"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="26">
        <location>
            <begin position="516"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="250"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001214300.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="68379" checksum="2EEA003E461EBD7A" modified="2015-12-09" version="1">MVTKLKNNKIKLKIKFLSDVFIVWIENTLSYENFENTIKDICRISFDEKCTFKWIDDEGDPCTISSPIELEEAISVTSENEDNEMCVYVFNGQPIIPGMPCKNEVDGIYRKGAKRWKKFYYNNGHRFYGKNPTYKTQCLVCKTYIWGISLQGYQCIDCKISVHKKCHSNVHYKCKPNTVATEKDTCTRYFSSNQAFFNEFSFDKENITPKDINSFSKCILNHRNSENHILKVTGTSNKVTLDDFNLLTVIGRGSYAKVVQAEHKKTKNIYAIKIIKKEMFNCDEESDWVQTEKSIFELASNHPFLVGLHSCFQTDLRLFFVIEFVPGGDLMYHMQRHRKLPEDHVRFYAAEIVLALHFLHYNGIIYRDLKLDNVLIDSTGHIKLTDYGMCKTNIGPGDYTNTFCGTPNYIAPEILRGESYNFSIDWWALGVLMYEMMVGRSPFDVYEMDLNSTQTAEEYLFQVILDKQIVIPRILSVKAGNVLRCFLNKFPKERLGCNINLEIGLEQIKNNVFFKNFIDWGMLEAKQIQPPYDPQIQSDRDLQHFDKEFTDEGPNLTIDDPNIISSINQTEFEGFEYVNPLLMAREDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C354</accession>
    <name>A0A0N5C354_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C354"/>
    <dbReference type="STRING" id="174720.A0A0N5C354"/>
    <dbReference type="WBParaSite" id="SPAL_0001240900.1">
        <property type="protein sequence ID" value="SPAL_0001240900.1"/>
        <property type="gene ID" value="SPAL_0001240900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2420:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000002">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000008">
        <property type="entry name" value="probable glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="267"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="568"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="682"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001240900.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="89767" checksum="54B4F759462229DB" modified="2015-12-09" version="1">MAIEKDEVKRLLSFLELSMPKIEETMKNEVISQTIASIALKGEQFDKNLPKSVKKLIYTLATHLQPRAKTYQEYLMNLIFEKKIINDAQLNAALDYAHSKPKEIFNEEEFNEKCGIGIVYTTEMIHDVVNEVFESFRNEIISERYAYNTGKLMGLIRNKLKFADASEIKKYMDTKILELLGPKTEEELKGIKKKKKVVQEKCNGNDKANVPKEKVVEDDSSESIEELMKTRAHFHKPGENYSTDGYVVTPNTMNLLKKHLKETGGIVQTRFPPEPNGVLHIGHAKAININFGYAKAHNGKCNLRFDDTNPEKEEERFFHGIEDVVSWLGYKPDKITYSSSNFQQLFDWAVVLIKKGFAYVCHQKVEEIRGFEVKMSPYRDRPIEESLQLFYDMKHGKFPEGAATLRLKLTLEEGKVDPVAYRIKYVPHHRTGDEWCIYPTYDYTHCLCDSIENITHSLCTKEFQSRRSSYYWLCNALDIYCPVQWEYGRLNVGYTVVSKRKIAALINNKIVSDWDDPRLFTLAGLRRRGVPAEAINKFVAKLGLTGAQMVIDPVYLDAVVRDYLNINAPRTMAVLEPLKITIENFSELDLGDSVTVQDFPGDNSRKESHNVAVSNVIYIENTDFKLEQEKGYRRLTPDQTVGLRYLGIVLKFVKEIKNSVGKVTEIVVRGEKLTNDNKPKAFIHWVAKPKIVEVRLYNRLFKHKNPEDTEQVPNGFLSDCDPNSLIVIRNAMVDKYLEQVKVYDKFQFERIGFFSVDPDSSKNKIIFNRTVALKEDAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3H7</accession>
    <name>A0A0N5C3H7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shugoshin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3H7"/>
    <dbReference type="WBParaSite" id="SPAL_0001252400.1">
        <property type="protein sequence ID" value="SPAL_0001252400.1"/>
        <property type="gene ID" value="SPAL_0001252400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001252400.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19602" checksum="A0A3A56738E365AF" modified="2015-12-09" version="1">MNQLFSNMKSRFMNTFVFKKDDNDSFGKSEIRIKRQLSNKKNEMVIGRQYNSDPTTNPGLAAALKNVSKLPNNYYSVPKGILATRSITRSGSSDDEKSQCAVRPRSRTTLSEKANTLENSVLVNKKKPKFSYGKQIITSRKLRASFNKPKFVKCRSLDSTNMMSVKKGDLDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3M4</accession>
    <name>A0A0N5C3M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3M4"/>
    <dbReference type="WBParaSite" id="SPAL_0001256500.1">
        <property type="protein sequence ID" value="SPAL_0001256500.1"/>
        <property type="gene ID" value="SPAL_0001256500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001256500.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10372" checksum="051EA0E9E9FFF204" modified="2015-12-09" version="1">MNFLYEAKLASKESRNNSLAFVKVVKEMYLEKNKKEESKQNNKLLNKVKNSSTDNNYGVNKVFHETYISLLESQLDKQEVFYGKKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C441</accession>
    <name>A0A0N5C441_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C441"/>
    <dbReference type="STRING" id="174720.A0A0N5C441"/>
    <dbReference type="WBParaSite" id="SPAL_0001082800.1">
        <property type="protein sequence ID" value="SPAL_0001082800.1"/>
        <property type="gene ID" value="SPAL_0001082800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001272600.1">
        <property type="protein sequence ID" value="SPAL_0001272600.1"/>
        <property type="gene ID" value="SPAL_0001272600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="4">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001082800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001272600.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32566" checksum="21AF4675902D724D" modified="2015-12-09" version="1">MQEVLSEFLFSEDKDSGVILYVDDIFGYACSIKDLGELAIKVVKKLHACGLKLNKEKSRLFATNIDFLSFEFGQREIRPSSDYIKKIMNYKVPTNTTQVRRYLGMVQYFKNHIENASITLIPLYDLLKNENNKVFNFSEKCVQAFNKVNEQLSSRPVIAPPIFGLPFELMVDSCKDAVGAILFQMQEGEKKVIGHFSKRFKEWKKKSSALEIELRGIIMALNHYMDLLTGSRLTILCDHKPMSSFVKNSKCARVMDMLETINSFDIDIKYKNAASMKRKSNGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7I7</accession>
    <name>A0A0N5C7I7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7I7"/>
    <dbReference type="WBParaSite" id="SPAL_0001390000.1">
        <property type="protein sequence ID" value="SPAL_0001390000.1"/>
        <property type="gene ID" value="SPAL_0001390000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001390000.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18753" checksum="3CD42622CBA3EB98" modified="2015-12-09" version="1">MEKGISIGAVLSPSSNDSFKNSEEDISPHISRMERKFRLLGLEAEMDKIDALFLSLSPGITEAYTAEFGDPTNYTTFVNNLKKRYDGRQTRLWIETTLADMKLNERSSKFEEDLGYLCSLVRKTMPNCTDKQRLEEMKRRIHTKLTPHSDLWKFVIMSSYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Q6</accession>
    <name>A0A0N5C7Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAX-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0001396700.1">
        <property type="protein sequence ID" value="SPAL_0001396700.1"/>
        <property type="gene ID" value="SPAL_0001396700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001396700.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="72492" checksum="47B53E3AC5466ADC" modified="2015-12-09" version="1">MYQPGQSQLMRMQQNPQNVQLQHGQPGTPIQIPQPGTPLSQGHGQQIRHQQMQRPGSGVNPNQMMGGNVYQQTQQIGNPRTPQMQHTGTQQQNFHPQQQAHHQQFNIVQQRINQGQPRSPMGVFQNIHTQHGMKQQIPNPASVGSISNQPRTPQNIMNPGSNAPPSNQNLNINPPSNQGINMNPSSNQGINMNPSSNQGINMNPPSNQGINMNPPSNQGVNMNPPSNQSINMNPPSNQGINMNPSSNQGMNMNPASNQGISHNVPSNQPMNISHPPNQTMSMNPSSNQSINMNPSSNQQMNMNPASNQPMNMNPASNQPMNMNPASNQPMSVNPPSNQPMSVNPPSNQPMSVNPPSNQPMSVNPGSNQQMSMGSSVNMPMNHPGSGEQIYNMTPNQGMYHTANPQMVNMMNQQKTSPNFMVQRQHPEYNNATRNEDGRDMFDIDNRIQPVYRKKAPEEGLMSQSNYPSSYEYITTDPIACIKVAILKDLRISLKNVNDTCARLVEIRLEEAKRNIEAVPTMEKENIEEDEFNDAMDDTTIMLDENMEIKSMSQECKDAHNLYVDAMNNFFVIVDRIESHINVLQEATKIQSRLDRMFNGEPKMGSDKESLSYLQYGYGYAEYMTSMKEAINNSMAQVADLLSDFRKAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Y8</accession>
    <name>A0A0N5C7Y8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001404800.1">
        <property type="protein sequence ID" value="SPAL_0001404800.1"/>
        <property type="gene ID" value="SPAL_0001404800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001404800.1"/>
        </source>
    </evidence>
    <sequence length="1422" mass="163538" checksum="A7B34685090AC8CC" modified="2015-12-09" version="1">MYQKINLVDNGKIDEKNTINEDNPSTKQGGEVRTAVTGISPFYKSGIEQTKAEVRYGSSQNLQYQSGDYKVKESQEHNRMTIIDPKVNTNSNIPASQIFQQKNLVGDFPSQHTKRSFMNLDPLEQKRFKSLERRPVTTTNYLQESVERHREMEASKLKDYLKATEKDANKPWDKPDWPGPKQDHSESLRELEQMKHAIETLQKQVYFTRAKSMSDLRSKPMPNIDNNDQTNVHARSRSQDPGWLIRLRKNRYLQNVLSNNTPQSLSGRTISADNIDKTSSRMSLFSNFSSKNMSEGLEGLPEKDKDLFASEEGRPDKGGDPIIWNHKKQLHLSKYTSNIFYAADNGSGKSHIQKLKNVYFEQIKQDQLKHNRHKTSPLTNNLNRNSSTLSHHLRSQLVSPTLPNIVEVPREEGGSEGEDERNSLHSINLHKNILERRTTFEEVEEIKREIQGPNHTPTFSISQKSPYQKTTLGDSNSSSRVNYQKQQLILPEKVSQASQPSHIPQKQPEHEFHERIMSPTIDRQLHIQTQNLPKPILKQNYKTSTQYQEQETGYSYQHYQDAQVHQSTTSTLNPGGIQKSMDKSQHLDPRNQTISPQPRSVSTTFEMLDEEERIRIMHENLKKHRQRSSSQSRVPKYPVASFNGPFFNLEEISRNNLTNNHHTPYTREQEIPIIRQNNEYNQPIYISKQHTMTKEISTSEMELNNDTKFTDNDNPIHNNGVVIWPPLPTKSNEERSRPSSAMAKSMYDPERRREFERQKQLEYEAMSKREEEKRKYIEKQLKAIQIQQQKLFEQQQKMMENEKYVEEGKNFQEYSNKIENQQIYQHEVNELVKNSMHESYISPSDQHNLRIYETRPISAMSVDNPLFTTGNGISPNSNPTWKRTYVLDSNEKKNIEKNEIITSDVLLEKDQYDIDILKRRETFIEKPDKPPEIVRIGKRWQPPPDEPYIWPQLRKPLNIDAEGISRGNSNVYSPPQDNADEYKWAPIVNDPGYKKENKNFTPQNSPPISPVRFGGLQTLDEVNKRQTKHLIKPTPDGSHRPSPVFKAIRHTPSGGFYPHAPNGIKIVKRRLHQSHSNLTDDPSYGTEEEDIQIIHERNFHGIDSPSRRGTPMGRSQSVHDLGREQEEINDWEKIYDLPAHSSTIQGKDIPHNVNLKKRLALFESQANLIQQKYAEKANHERRTSEITLISSSSGGYHQQPSQTVDSTHSNHSGSSYSRKQHTSYNQGQSSQQPLQHTSTGSGLLRRVDSRTGQSYGSIQHLNQQMTTQVPIVKPRNSRNHLQRPASVTPMMASEPTVRRVPSRLAQAQVSPIPPSYNTARPYVPKPLPDGYRRPLSPLSGYLAVSPRSPPPQNPGQTKRMAQQLMQKAVSAQNVIHGGRQSVPVNLMRPLPTRKSHHGNTLIPPPIHRQPSSLISPNGSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8S2</accession>
    <name>A0A0N5C8S2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8S2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8S2"/>
    <dbReference type="WBParaSite" id="SPAL_0001431300.1">
        <property type="protein sequence ID" value="SPAL_0001431300.1"/>
        <property type="gene ID" value="SPAL_0001431300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF26">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001431300.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20268" checksum="293C497C4394286C" modified="2015-12-09" version="1">MKEFPLELNFKNNILFSPSGNATENYAVELKMKNTTKEKQAVKVKCTSNDMFRIAPPVSVIKAGETLSVTLTYNGSKPLPEDNKHYFVIYSLVVSNDDPPRKIFNNDKDKKTECMRLFAFFKKDEGDTKNDDKTNKKEDNKDEKKNDKKEDKDDKKEENKDEKKEEKKDKKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8T8</accession>
    <name>A0A0N5C8T8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AcidPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8T8"/>
    <dbReference type="STRING" id="174720.A0A0N5C8T8"/>
    <dbReference type="WBParaSite" id="SPAL_0001432500.1">
        <property type="protein sequence ID" value="SPAL_0001432500.1"/>
        <property type="gene ID" value="SPAL_0001432500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="130"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001432500.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32789" checksum="98E9BFC0FED8FBB0" modified="2015-12-09" version="1">MSNLIHINLFPYSLSGRYYKKWTTKDNRLVPNAWLSFMFLAIDVAIALVVLILIYDFGIRQFITPTIRGFSCSDTSIRNEFHANTISAKHLLFVTLALPLGVIISSIYINNLQRNVALTPSVITAQVSHYYLHYLIIYFFMTVGLEIIKCQVGRLRPHFVTVCQPDLSICDKNPNAWIDDVKCNTTDRRLRNIRTSFPSGHTAAAVFSTLYIFGFVTTIIKSKTFEAVLFKYGIITCYSVWTIICAITRVTDFWHFTSDVFCGAIFGAISYYVLFNIIPSFFPSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Z1</accession>
    <name>A0A0N5C8Z1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Z1"/>
    <dbReference type="STRING" id="174720.A0A0N5C8Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0001437400.1">
        <property type="protein sequence ID" value="SPAL_0001437400.1"/>
        <property type="gene ID" value="SPAL_0001437400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="391"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001437400.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="86813" checksum="C39CF9E3F8E32D4A" modified="2015-12-09" version="1">MSESNNDDKDNTKNSQNDDSTSDKNDAVPKILSLRNLRENDEFKQLCFDNSYNDKRLSSNLEGPSNRRTPINEGDERLYPFNVSNSLRSKNNSPLIKDSESKSIYRNAFMSLVTGNLEKNGNNGYSNDILNNQYYDGSQKVKRYEYPDDMTTGHKIYSHFPYPEALSDTFQGKLEYPMGNVTHHYIGIRCMESQQIDNGFSNEVNDCDKDTLIKYLCKNRIPYPNGICQGISIACGLKVLPNYVFDNIKTSYITTICLSNNLLTSIPESIGLMRNLKYLDISYNKLVTLPKSLSKCYNLVTLDVSNNLIVQFPDNLGLLKKKLEVFSIYNNPLRHDLMHVLTSSDPGKVMLEILQKRFYSKQVPPPRRDWHFLTQVKTGDNHPNLPFISVMTYNILSYKYLFNNRFNYCPDEELKWEYRKAVVFEEIFHYSPSIVTMQEVPKGDYESYFHPKLCENGYDGLFFPKSRIKKTKDELTQHVDGCAIFWQKPLFSYVLHFDIEFKSMVDELFNDDDEMSRRVQAFDNVALIVVLTIKGEQREGESETTAVPNGIYCRPLVVATTHIHWDPDYADVKLIQSMLLMKSLYDRRRYIANQLRCDIEEIPIIVTGDFNSRPNSSVLEYIRRKQLPKDDDGLMLFKNCEKLNRISSNPRDFHYYHHGLKDLEMVDMSRYQFTNFTPEFADIIDYIFFTSSTISACGIIEPPSAEWIKNSEVIGFPHPHFPSDHIPIVANFYINNNDNNGIIPNPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9A7</accession>
    <name>A0A0N5C9A7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9A7"/>
    <dbReference type="STRING" id="174720.A0A0N5C9A7"/>
    <dbReference type="WBParaSite" id="SPAL_0001449000.1">
        <property type="protein sequence ID" value="SPAL_0001449000.1"/>
        <property type="gene ID" value="SPAL_0001449000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="282"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="831"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001449000.1"/>
        </source>
    </evidence>
    <sequence length="1138" mass="130281" checksum="639295D83ACECDB4" modified="2015-12-09" version="1">MAEEPDNNEILGLFDNSTQQPAEESADDQLINALLHNKKSMTLSEQGMKAVSKIFSCKRISHETIESITDRMGVHQDLQFLAPAFSTPYYSKLKMRSVDSNLAKMQDHLLQSVCMLSHNVEAATGDNKSAVLSALINIKYVVDGLSDIRREVAFRNFSPKFNKGLPSVPLDMEEKVTRMDSSERISILPKHAEALFKNVADTPQDLLSFIQRENRKRSYNNTANIEPERYVIINPNMPPNTIHQCLPFWQKIAPTDTVLLDYIINGVDIGILCEPTQHKIGKNKFSSKEEEQFIENEIKDLLRSNSIKEHDNPKWISPLMVVTTSKMRLVLDLSSLNDYIQHFSFKCESIKDVTDLLEPKAFLTSIDLSAAYHSCAVRPHQTEYLGFRWNNKTYIYLVLPFGASSAPRLFYRITNTLTATIRANGIKMTRFYDDFLITHTDKDLLTRHTEYCMNLLRAAGFSINEKKMIDTLKEELRLPQDKLDNIIKAARHISNLKRVVARQLYSLLGMIEFSSYANFLTRIKARPLQRAVNKCIGFPPNYNRYVNITTEIRQGLAWYINNIEATNGLRYNQDHASIEVYTDACNVSYGGIVYFPDYTSQSVQGYFTDDLLSKHINEKELMALSFTCFGLLQNTYNKIVNIYCDNTTTLALVHNKGSVNKIFLSSETEKLLDFFYEHRLYINLYHIPGSYNQVADRLSRTMPVTLQGPTEATLTIKAREEIKEFLLNKFNVIISVDLFASYENKFCDKFVTLFDDNRAFRRNAYSFNWQGLIDEEVIAFPPCNQVLRVLRKAGTDKCNLWLVALILCNSNEEPKAQSGTFPNFLQVALSDMDPEVSQSIQQSYSVNTQKSYSTHLRNYLNFCKENGIKDEHFSFKNLTKYLSKIATSAAPSTVNTIKNSLVAIAKLRKVTFSSHEKTLLSKLIKGIQVNNYNHDIQKYMTFDLDIILRHIENNPASMEMSIKDLTFTTITLISIVSPQRMNELARMSLDHMTLSDAWANFTIPGRSKNSTATHKFHRMHIQKYANPSLCPLTALSLYLKRTEPIRTSQNLWISYFKPHKNVTGTTLGRWIYNYYLTAGLDIGRPHNIRGAAASKYYEIAGSITNMIEAINWASEHSFFKFYHKEIGNNFGATVLSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAD3</accession>
    <name>A0A0N5CAD3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAD3"/>
    <dbReference type="WBParaSite" id="SPAL_0001485500.1">
        <property type="protein sequence ID" value="SPAL_0001485500.1"/>
        <property type="gene ID" value="SPAL_0001485500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001485500.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63796" checksum="972BAA953DB24DEA" modified="2015-12-09" version="1">MIDDSFIQYLSQCMQSNHAPGIMAAYREVLDGSRPIEDKRDVTFRDKYHCDITINSSNFITVSDLIPDDDHDAKIYNSNDVTKLEINIHAKKVKKNSFYKVKCSIASKINKVLSSVSCVNELSLEFFGPEFVYNHIQDIIMEIKNDYISMLSINFKKNDSPSIFKPEKPLITNEKFLHGFKNLKCFQIEKHMFGYTMYDVTSIDILSKIKGLSLHLNGFSNFYPSSPDTSEKVSLNGVLSKIIKNKIYFSLSTGKFESEPRFMSWLEDSDVSSLSLITSIEIMNFTVMNLHKLTKFLPYMINLQSLKIGIVEVGPTFNMENRNLSYIYKSFKNLKQLKTIVISLAYSEDGCDLFSRIFKEIGGTINNGADQDMYQKDIIPFLSMAPECLENLYLNGKFNITNEITSKLNKSFPNLSFLFFGSLRNAETKSIEVFENLEMFVNLSPFTFELPKNIQLCMVGADSRTSNTEDFPDFLHNLSKASYSDVDSNIPKIFARYKKCFEHYRGLKCLKREYDLYGSVKGKIFFNSCYYLLKFKECIGEICNLDKLSNLEMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC75</accession>
    <name>A0A0N5CC75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC75"/>
    <dbReference type="STRING" id="174720.A0A0N5CC75"/>
    <dbReference type="WBParaSite" id="SPAL_0001548400.1">
        <property type="protein sequence ID" value="SPAL_0001548400.1"/>
        <property type="gene ID" value="SPAL_0001548400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041428">
        <property type="entry name" value="PHsplit_syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18012">
        <property type="entry name" value="PH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001548400.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59462" checksum="CF09F2776CC05593" modified="2015-12-09" version="1">MAKNRSNTSLDVVHSGMVLISDGKGRGKLSKLLLTKELLYIQIPTETSNNNNSSIPTVTQQQQTSNAFDSGESTTTRTITIQKRSNILGISIKGGVDETATLPIVISKIAPNTPADECTQLFIGDIILDINGISVEGRTHDEVVKILKDIDTTVTLTVKSCPQIAPILKTANSEKVKTAHSISDIFTEPVPFKSVLKSSVSVNDIKSGNKNSDEPILQGDGKDGWKTINKLPLPMAQLSRYLWGTDKIRNNAFELRTVDGRTSNIIHCEDKKAVEQWLKQIQGHINNLNHKSMKISNKFLHTSEKIQYIGWADERMSETFCDDIQIRWKSRFIILKGTDFCIFESPPLNSDDLNNKCLFMYKIIETAMKTAIPKKDRRDCVLEIESADGGKHYLSFNSPTQLQTFESTYYDTIYKSIKLTQCKTFACSYLGRPSGLVIHIVNGISLYDIPTKQYIWNYKFSSLENSSDDGKIRLHLVFKKIVNKQKEVIEVRDIECDQVINLIMTLHSFYIAKIMGVYPDYLKVMPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC84</accession>
    <name>A0A0N5CC84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC84"/>
    <dbReference type="STRING" id="174720.A0A0N5CC84"/>
    <dbReference type="WBParaSite" id="SPAL_0001549300.1">
        <property type="protein sequence ID" value="SPAL_0001549300.1"/>
        <property type="gene ID" value="SPAL_0001549300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000064">
        <property type="entry name" value="Small G protein-signaling modulator 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="409"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001549300.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="88595" checksum="7938C04F17FDD2AE" modified="2015-12-09" version="1">MIRTRGSVIKSADSFLNTSSPSGREFVYSLHQNNKLTLLYGKNNVSISTFDDNKMLKGYLSLHKEFSGYIIVKWTPNELMNLNNSQSTAGTSTSNSSSSLTQTTTAFPFTSSPYPIDILVLTKHIISFNMKTIAYIHVHQNDEMGISTVVFVDTDGSQQASFSFMNSKNLIQFIGTLETCLNPFFKLDPPMYENKETQEKSLPKLKKKTTNSVSKASSVNSEDEGKQNQVNDYVFRIVLNSQMKNKLPDKGSGKMKHQHTAFSFSAPSNNNNLSNFRSFEIPKSAPAFIPNENISNANQSQENLLPSEGDNKMNTSQDNVTTNISNALISMKQHILSRAFLGWLNYCKHVKTVRKHLLGIVNVQPIKWYDEEDANDNNIVTKEYWKYLRENKNDNSLWEIFIGKVYHYGIASEVRKEAWLYLLKVLSWEEEIEDKIEIFKENYNRDKLSWLEIENIVIQRDKEAFISARLRHFNGSGVHDDDDSECTSINSHQYECTSFEEAFGDEIDSGGYKGRNHIYEDTQSNDKNQEEEDLINNFGTNLHRIEKDVERCDRSNQFFKKSANLKKLKRIMCSYVWRNLEEGYVQGMCDIAAPLLVIFDDEVIVLECFSKLMERMRLNFPQEIGMDNNFLYLRHLVEVTDPELFSMIMAHGDFTHLYFSYRWFLLDFKRELNYDGVYRLWEIIWASNIGGLSKYFQLFFALSLLTANRYIIIENAMDFTDVIKFFNDMAEKHDTQKLIDIARAHLKDFRKFTIDNCINYQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDG4</accession>
    <name>A0A0N5CDG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad21_Rec8_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDG4"/>
    <dbReference type="STRING" id="174720.A0A0N5CDG4"/>
    <dbReference type="WBParaSite" id="SPAL_0001590800.1">
        <property type="protein sequence ID" value="SPAL_0001590800.1"/>
        <property type="gene ID" value="SPAL_0001590800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="504"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001590800.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63292" checksum="EAEF28434D349506" modified="2015-12-09" version="1">MFYTQFMLAKKGPLAKVWLAAHWEKKLSKAQVYETDVVDVVNEIMQPKVKMALRTTGHLLLGVVRIYSRKTKYLLADCNEAFLKIKMSFKSGEEEHMMSEISSVSGASSSLPEVMQDFDITIPEFNEYDLQKQMRINQSRIDDITLKEDSVPTTTGFDISEDFGGDDFGDRTLGLRFGESDAQEIERHRERSLSNHSALAGPMADISDIKSVEDLRDSVHIELGPPGEFGDVFMSESDLIGEIESLKEPGAEFEEAHVPMEAEPSVGDGTLPQLDSFNLEPLHPSQIEIVSKAPKTKKKRRLIIDEVKILSGEEMKANMSDFSATVQPLDLAPPSKKLMRMVEYGQTDKLFNNPLMKDMVDGELQNFYKMCCVARTKEDVYDGASVATDLELSDDIDLAELPSNHAIEGFDEFAEAISPSMTPLQAMENLDTTLIHEEEISKGDKELDKRGEIKSPEAKRRKSRTVTDKSFIEEDEEGDEGIRCSRRTHAILNSINNKLKHSENNEIIFTDLLTKSSSRRTIAQKFYALLELTKNLAIKVEQDEPYGEIKIKPGPQLAHILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDL6</accession>
    <name>A0A0N5CDL6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ELM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDL6"/>
    <dbReference type="STRING" id="174720.A0A0N5CDL6"/>
    <dbReference type="WBParaSite" id="SPAL_0001596000.1">
        <property type="protein sequence ID" value="SPAL_0001596000.1"/>
        <property type="gene ID" value="SPAL_0001596000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="6">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001596000.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="55721" checksum="68AF64D0590463BE" modified="2015-12-09" version="1">MEENNTNGTSETDLEPIIESPDDVSKEPTVSDEEMEVDGEELGSDGINVNVKTRSRRKENNEPFLALDVFNGNKSGTNLLLQIKQEIRLGSQYQVDESLLRSLDIMYNNPKLRVEKKFEGEILWNPNDPKFDDEKTLNVIDNDRKYEIPLEKTLYKIQKMNFDYDKILEEIPVKEVKEEIWTPEEIIQFKYCFQRFGKQFHKYKVILTTKPTKAVIERYFNYKYFDKYRSSYSLNEPLSHVDMALKLVDKPFLIMQDEAECSNCKYKTKCYIKLEEEEDVLCEYCYNYKKYNGELPDGEKTRHISEESFNHDSLKIKVNGVRRKLLEVFKSNADQNDENYLFPLSEKSPLQRHREFVQKHIEKRRFFDQFMVEYEKLWKIINRYKTYLEGEIKYPHFGTHFFHVVNRELLPSAGRWVEWESSLQECIFDLCQTFQFNIPLVERELRGLVSAEMLAEFIKFYPRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDZ9</accession>
    <name>A0A0N5CDZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDZ9"/>
    <dbReference type="STRING" id="174720.A0A0N5CDZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001608900.1">
        <property type="protein sequence ID" value="SPAL_0001608900.1"/>
        <property type="gene ID" value="SPAL_0001608900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001608900.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="22295" checksum="286C66D5CE46E7D7" modified="2015-12-09" version="1">MARVIILRKDDDILSTKEIRQRLHRVRFDKNLGNENNNVRRVVLPRTPKHFAWATTKKNEVPEFTFRMQDQWHFEGDNIALRVTFNGVPKPAIYWFKDQQPITASMKTMINNGDNSSELIIFTAEKSDAGFYTCRIENNLGIRESHAQIYIKGEEQTRCVRVMPRRNYLSERLYRPMYHEISYYSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE47</accession>
    <name>A0A0N5CE47_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE47"/>
    <dbReference type="STRING" id="174720.A0A0N5CE47"/>
    <dbReference type="WBParaSite" id="SPAL_0001613700.1">
        <property type="protein sequence ID" value="SPAL_0001613700.1"/>
        <property type="gene ID" value="SPAL_0001613700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001613700.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31776" checksum="427F713AACBF842A" modified="2015-12-09" version="1">MPHANKPVVEVTHIDDYQVNFILSNTDLSMANSLRRVFHAEVPTLAIDWVQMDNNTTVLHDEFLAHRLGLIPFLSDIKVDKIRNFRDCDCVDFCKQCSVEVWLRVRNDDTATRSVTSDDIVSADPEVVPAAGKYLKPHYKGDFTEFERLYGPILIVKLRQGQELVFRAFVKKGIGKEHAKWNPTAGVTFEYDPDNALRHTVYQNPSDWHKSEHTRLPEEIYEATFDALGKPNKFYIGVESSGALKAENIIINGIKSLRKKLVDLKDCLEKEHINSTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEC4</accession>
    <name>A0A0N5CEC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEC4"/>
    <dbReference type="STRING" id="174720.A0A0N5CEC4"/>
    <dbReference type="WBParaSite" id="SPAL_0001621400.1">
        <property type="protein sequence ID" value="SPAL_0001621400.1"/>
        <property type="gene ID" value="SPAL_0001621400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="79"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001621400.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44155" checksum="BC5BDB73224B0D57" modified="2015-12-09" version="1">MLNVNKPVEVAVIDEIQMVRDDQRGYSFTRALLGVPAEEVHLCGEPAAIEIIKKMLDPIGEHVEIINYDRKSPLKICDYALEDISNVQKGDAIICFSRKAIFYYAKKFRDMKIPAAIIYGKLPPKTKLAQAAKFNNPNDPTKVLLATDAIGMGINLNIGRVIFESLYKSVGGLIENYNALQIAGRAGRFGSIFEEGKVLTLKNKDLKSLKEILEKPIENISKAGIAPTFEQIETFSYHLPTATLTNILDIFTSICSVNDTYFLCDFESIRDLAKLINPINLPIGVKYVFCCSPLKVDTTLSSVSFVKIARKFSSNQPITYQWLCDLIKYPFQEIRTSNDIDILTEKYDLIILYLWLSYRFPEMFPDYLEVKELEREADRLIQNGISMLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF08</accession>
    <name>A0A0N5CF08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CF08"/>
    <dbReference type="WBParaSite" id="SPAL_0001644600.2">
        <property type="protein sequence ID" value="SPAL_0001644600.2"/>
        <property type="gene ID" value="SPAL_0001644600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF164">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="98"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001644600.2"/>
        </source>
    </evidence>
    <sequence length="217" mass="25767" checksum="3766E2AF5E4075D5" modified="2015-12-09" version="1">MKDKDFLDKGTKKNYLKKLEYMKHDFGHFENLADTQLMEKCYSYFNFSIDDGVDGMLYNIKNYEYFIPNHLRWRCTRYIKFKQSYNEFEFLKLVGNSAHYFFPKNTFTINLPFLNYPYFDVKFPMALNYGSIGFIIGHEITHAFDNDGIEIDYSGKKNKSIINEDSSKNYNEKADCFVQQYGNEIDKNSGMKINGRRTLDENMADXQRHLIVKLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF79</accession>
    <name>A0A0N5CF79_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF79"/>
    <dbReference type="STRING" id="174720.A0A0N5CF79"/>
    <dbReference type="WBParaSite" id="SPAL_0001651700.1">
        <property type="protein sequence ID" value="SPAL_0001651700.1"/>
        <property type="gene ID" value="SPAL_0001651700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037689">
        <property type="entry name" value="BAG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334:SF6">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001651700.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45376" checksum="EADA38FEED277BEE" modified="2015-12-09" version="1">MRPGNFSTNGEYTRTIPVRTSPRPSEEFQQQTFYPQQGQQGQQGQQYNNQPFYQPNQSSQPTYYQNQGYTVPPQDYMQNQYRNSYMSGDGKTKSVPIKITKTSSVSSNDSQNSGSVNNEKPVNVAQQKDNSNENQNDNKEIKIEIKTDPPVPKSTDPPKVPSIVVDGVCINPNICVVDIEEKPSTDDSKKKRTKAGKITREASIDDFNSSIIDVLDDTEARVEKLREQATALEQEKEQLLDILKHIKLNIDLLKGEGDKEDVEVTSARILKRCEAVTVSVNTPRNPTQAKALAEINELVEKACLRIPENIEEAKECLKRYSNACNQDIPDGAIDHKFEAKVIECTADDQKKVKKKLANIIKQIDVIQKMKEKKGDVKENDSKTDTENVTEVKVDHVNNTKSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG74</accession>
    <name>A0A0N5CG74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG74"/>
    <dbReference type="WBParaSite" id="SPAL_0001685300.1">
        <property type="protein sequence ID" value="SPAL_0001685300.1"/>
        <property type="gene ID" value="SPAL_0001685300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001685300.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15726" checksum="657D1575B5FBC9FF" modified="2015-12-09" version="1">MLENEIVARKCLLCNKISKNMTKKRIIRKYPKYLFVELTKNIMDEDSESMGIDFISTKDSVYVNEFFTPNTPYKLKGFIAYERFGRRTGHYVTYIRYEDKWHCLNDSQKPKEIDENELPTERSTVLLYEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH01</accession>
    <name>A0A0N5CH01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH01"/>
    <dbReference type="STRING" id="174720.A0A0N5CH01"/>
    <dbReference type="WBParaSite" id="SPAL_0001712600.1">
        <property type="protein sequence ID" value="SPAL_0001712600.1"/>
        <property type="gene ID" value="SPAL_0001712600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000082">
        <property type="entry name" value="Glutamate-gated ChLoride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022268042" evidence="11">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="269"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001712600.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="61317" checksum="E8B37FDA8230BE14" modified="2015-12-09" version="1">MNSKIIYNILLLFLLFKSIISKKLPIPCKRTIFSRRTTNYKAWREQMIICELLVDNKYKKTERPNGMTAYNRTAGPVLVKTSMWVESISAVSEKNMEFVAQFRFQQRWYDERLEFMRQNGFKKDDYLNVERDQILWQPDTFFQNERNGWYHTLDQENKFLKVNSDGLITYNRRLTLILACNMHLKKYPMDKQKCLIDFASYAYTTEDIIYEWDINGVTISPTANGALPNFEIESFEMASCDSITNTGKYSCLRVVITLNRVFSFFLLQLYIPSAMLVGVSWVSYWIDWKSTAARVPLAIVTLLTMITQSHAINSNLPPVSYAKAIDVWIGACVVFIFASLIEYAVVNYMGILDEHRQIKKIASNHTRLTSVVDTNRIINKNKNENRIDIFNEPNLNNKKSTKKSKIASSIRDRRRTTFADTPIYHDEGLDIDEEIDTNKFYTESEDIYDYSMQKLPDLVYIGQRKKVELVKWCSLLSSRKRAERIDIIARLVVPIAFFIFNIVYWNFYLNDMMMQSFDGSKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH67</accession>
    <name>A0A0N5CH67_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH67"/>
    <dbReference type="STRING" id="174720.A0A0N5CH67"/>
    <dbReference type="WBParaSite" id="SPAL_0001718900.1">
        <property type="protein sequence ID" value="SPAL_0001718900.1"/>
        <property type="gene ID" value="SPAL_0001718900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047822">
        <property type="term" value="F:hypotaurine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001718900.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62571" checksum="CF65047D19F1D854" modified="2015-12-09" version="1">MVLGKKEVLIIGAGASGLPSIRFALLNDVTPVCFEASNDIGGLWRFKPEECDESSVMKSTVINSSKETTAYSDFPPSPEAPNFMHNRKLLQYIRDYANEYNLLQYVHFNHRVIGVKRSPTFDDDGKWIVSYTDDKNNKKERTFDGVLMCNGHHAHPHFPEPWPGQDKFQGKIIHSHSYKDHKGYEDKTVVVVGIGNSGGDIAVELSRIAKEVYLVTRRGAWIFNRLYTYGVPIEFAFSRRIDMIMRPIFPIWAVNLLLQKRMNEKMDHVTYGLQPEHSVLSAHPTVNDELANRLANGTVVIKKNIKSFTERNVIFEDESIVEDVDAVIFSTGYSFNFNLIEDGRLIPVENNNVNLYKYMYPPSLAYKNTLAIIGLIQPYGSIMPISELQARIFFEALTGKVKLPTEKEMMQDVIFKKKEMAARYVESQRHTIQVDGPAFMDELADIIGCKPKPFKYLFSDFPLFKALIFGPNVAYAYRLEGNHQFKGARKALLEVDHRATYPTTHTRFIKEDVWSKSYLLKCFGSIEPFLIFIGLLTLLKFILDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHQ0</accession>
    <name>A0A0N5CHQ0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5CHQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001736400.1">
        <property type="protein sequence ID" value="SPAL_0001736400.1"/>
        <property type="gene ID" value="SPAL_0001736400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001736400.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="34211" checksum="0810872458CFBA4C" modified="2015-12-09" version="1">MSDDFGRLISKMQSTKSTTTDNTKTMSYFLTSKKKTKSYKFHDRYTFSQTTDRILESSCYHIEGLVCNLCKYTKELDLAHLPEIVFANNELQIESNDGNYINFNTFDSIKMIDNSKYPDFKVSMSDAWVATRKQYKDLKISGKPFDWSYTTFYKGTVSENATVVETTEEIDIEKLKRRDPILEYDTFLLYEDELHDNGLSKLEIKYRIMEECFLVLQRFFLRVDDVIVRVIDTRLYHDVQNPYLLREWTFREQHVRDMSEECLENIKNEDYLAVNLPLIDRTMEQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI89</accession>
    <name>A0A0N5CI89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI89"/>
    <dbReference type="STRING" id="174720.A0A0N5CI89"/>
    <dbReference type="WBParaSite" id="SPAL_0001754600.1">
        <property type="protein sequence ID" value="SPAL_0001754600.1"/>
        <property type="gene ID" value="SPAL_0001754600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001754600.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25299" checksum="7363819B78573A6E" modified="2015-12-09" version="1">MASGMWKKLLRPKIEKISSHQAFIAAYTALKPIWLEEQSKAIKLSPDEQRQISLKQNDALKTLIFNCGLDEKTYSKNYPVPLLTNNDLNLELKQYEKDLDDTFRKEVGKIIPLLKEHTIHGVEKYLATFDKALLSLAKTQARKDILDRLSVYYVPTLIKLDKGLITYYNQHLNNRDPDESYTLTSTFMDIIDLMERDGHRARLGEAIYPPKQMNNVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CID1</accession>
    <name>A0A0N5CID1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Collagen IV NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CID1"/>
    <dbReference type="STRING" id="174720.A0A0N5CID1"/>
    <dbReference type="WBParaSite" id="SPAL_0001758400.1">
        <property type="protein sequence ID" value="SPAL_0001758400.1"/>
        <property type="gene ID" value="SPAL_0001758400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1090">
        <property type="entry name" value="ALPHA2(IV)-LIKE COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="10">
        <location>
            <begin position="704"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001758400.1"/>
        </source>
    </evidence>
    <sequence length="945" mass="92815" checksum="27C1B9A6826F2A47" modified="2015-12-09" version="1">MKGDMGIPGIPGKDGFPGLKGERGLDGAPGLPGLPGLKGESGFPGLPGMPGEPGPPGQTVVGPPGQPGFPGLKGDSGLPGLPGQPGLPGLKGNAGFPGAPGLDGPPGPVGSPGQPGFPGEKGEPGLPGLPGFPGAKGESGFPGAPGQPGSPGLPGLPGTKGNAGLPGFPGLKGEPGFPGAPGQPGLQGPPGHAGLPGLPGLKGNAGFPGAPGADGQPGFPGMKGEAGFPGLPGPKGDQGLPGFPGPKGEAGFPGAPGLPGKDGLPGLPGLPGMKGEQGQPGFGIPGAPGEKGLPGIPGKMGRPGPQGPPGLDGQPGFPGLKGEPGFPGQPGFPGQDGLPGLPGEKGDSGIPGLPGAPGPIGPEGPRGVPGIRGDKGDAGFPGLPGMPGKDGFPGLKGERGLDGQPGQPGYPGAKGEPGLPGLPGQEGLPGFPGIKGEPGFPGAPGLPGKSIPGPPGPPGQPGYPGKDGLPGFPGIKGESGLPGLPGLPGLKGESGQPGFPGQKGEPGLPGLPGQRGLDGPPGLPGRDGQPGFPGEKGNSGYPGPPGLPGQDGLPGLKGEPGLPGFPGMKGEPGFPGMKGDAGYPGQPGLPGKDGLDGPPGLPGLPGAAAQVMAGPKGDPGLPGVPGIRGEKGLPGLDGPPGPSGPPGYPGQKGDSGYPGAPGLPGEKGEMGLPGFPGLEGPPGLPGQPGISGPPGQPGQNYKDGFLIAKHSQTTEVPNCPEGMTKLWDGYSLLYIEGNEKAHNQDLGNAGSCLPKFSTMPFMFCDLNNVCNYASRNDKSYWLSTNKELPMMPVNEGEIREFISRCAVCEAPTNVIAVHSQTTSIPNCPDGWDSLWVGYSFAMHTGAGAEGGGQSLASPGSCLEDFRTTPFIECNGARGSCHYFANKFSFWLATIEDSKQFSTPQSQTIKSGGHRARLSRCQVCMRSVDNQPQQQYAQDQYSRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIN1</accession>
    <name>A0A0N5CIN1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIN1"/>
    <dbReference type="WBParaSite" id="SPAL_0001768600.1">
        <property type="protein sequence ID" value="SPAL_0001768600.1"/>
        <property type="gene ID" value="SPAL_0001768600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895998" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001768600.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18466" checksum="9F0F27BDA5958540" modified="2015-12-09" version="1">MVFFKALTVFIVCISIFRDIISKSTLCKYGKTMKECNVLLTGYIECSLCKNKKNRHVKIYLDERYLVEWIDADCNQLFFIPKYLEEPHKEDYKASFYLLCNSETEKVVANKTPKYMEHLKTVKTYVYMFETIDLTTTKERNNRKRRNGLKKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Q9</accession>
    <name>A0A0N5B1Q9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Q9"/>
    <dbReference type="WBParaSite" id="SPAL_0000001375.1">
        <property type="protein sequence ID" value="SPAL_0000001375.1"/>
        <property type="gene ID" value="SPAL_0000001375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000001375.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32134" checksum="674E0D5C1D8144F7" modified="2015-12-09" version="1">MMARCFYRKLRLYSQPKDIITDNAKYVNSAHRGNSYVESYVHTLEDFGIKLKRNNERKIWSTYINEAVSYINTSVDPDIASNMTFVNNSCMQFCEGKVNPLIFLEYMKCILSGIDDKEKVSRSIRYLEFSSFAKIKAQLVNDGRSIKTVEIDDLYNSFVKTFGRKTRFSNIVNLITNGKSYSDASDLCTEITLAKKINGCFRCGSKHHLVKECKKKAKKVGNFADSLSGSEESSENDTIEVNAVQIVKKTILPDNQVPKCVQRNPSKIKFVAGVSGGRFKITGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B536</accession>
    <name>A0A0N5B536_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="12">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="12">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B536"/>
    <dbReference type="STRING" id="174720.A0A0N5B536"/>
    <dbReference type="WBParaSite" id="SPAL_0000118300.1">
        <property type="protein sequence ID" value="SPAL_0000118300.1"/>
        <property type="gene ID" value="SPAL_0000118300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000118300.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="46784" checksum="780F8400E55257FF" modified="2015-12-09" version="1">MFFNKFSLFNSSSKVIQHFCRNLSLQEHVSFSLLKKNGIPVPSFALAKNPEEAFKIAKDLPGSDYVVKAQVLAGGRGKGHFTSGLHGGVHIVYSPEEAKAKASKMIGSKLITKQTGEEGKNCNSVIVAERLFTRREYYFSIMLDRLTNGPVLIGSSKGGMNIEEVAAENPNDIITLPVNIEEGLTDNMLEKFVNDIEISGKNSDKAKDIIKKLYTMFIKDDATLLEINPLAEDVNGSIVCMDCKYTIDENAAFRQKELFSEQDLSQIDPLELRASKSNLNYIKLDGNLGCLVNGAGLAMATMDIISLYKGVPANFLDVGGGATTEEVTEALKIIASEGNQVNAILVNIFGGIVDCSNIAKAIIATAKDINIPIVCRLQGTNVITAKALIAHSGLKVFSCDDLDEAAKLAVKLSTIVKLAKESSLDVSFELHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5J2</accession>
    <name>A0A0N5B5J2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc transporter ZIP9</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5J2"/>
    <dbReference type="STRING" id="174720.A0A0N5B5J2"/>
    <dbReference type="WBParaSite" id="SPAL_0000133500.1">
        <property type="protein sequence ID" value="SPAL_0000133500.1"/>
        <property type="gene ID" value="SPAL_0000133500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000133500.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38667" checksum="E7C1386F528FE4A6" modified="2015-12-09" version="1">MLEGAATLLVFSCSMFIGSYVAGLIPLAFTLNENKVRLLSIFGAGLLIGTALSVIIPEGVVALYSIQEETHTLYPNPINNSNNKIKKDDNIVKNDVNNVISGNLLKKREAFHQEVSITEDKNYGKKNFNDHFHSHKEYHTQEIGLSLVTGFMFMFLVDHITNLTSTANSPLLRNKVTATVGLVVHAAADGIALGSAAASPKNGIQFIIFFAIMLHKAPAAFGLVSFLMLEGLEKFRIKKHLIVFSLAAPLAAIITYQILLFISTESLKDSSTTGILMLFSAGTFLYVATVHILPELQATKKGTGELIVISSMSPGHSHSSNTPQFQTKELILLFIGSIFPSFLNHQDSRQHLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B791</accession>
    <name>A0A0N5B791_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B791"/>
    <dbReference type="WBParaSite" id="SPAL_0000191850.1">
        <property type="protein sequence ID" value="SPAL_0000191850.1"/>
        <property type="gene ID" value="SPAL_0000191850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000191850.1"/>
        </source>
    </evidence>
    <sequence length="52" mass="6272" checksum="1FE5D16F1006CD75" modified="2015-12-09" version="1">MIVIIFNSIIINSILYLNLRRIVIDDYRNKKFIQKFNVFKKYCSSLIAFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B793</accession>
    <name>A0A0N5B793_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B793"/>
    <dbReference type="STRING" id="174720.A0A0N5B793"/>
    <dbReference type="WBParaSite" id="SPAL_0000192000.1">
        <property type="protein sequence ID" value="SPAL_0000192000.1"/>
        <property type="gene ID" value="SPAL_0000192000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF2">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000192000.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18954" checksum="16AB9F22A9C362EB" modified="2015-12-09" version="1">MVIESDSEGNYDQAIQTVKCYSWHYNYTFVILRQEKVPEFSYNCHYEDFMFRRHCIVANYAQKYKNEIKYIVFIDGDIGVVNPVHRLENYLPKDGEDILFYDRTFNYEIMAGSYIIRNTLYTRNFIRFFADYEKKMPESNGGRDNVALQAVFVDFMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7F4</accession>
    <name>A0A0N5B7F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7F4"/>
    <dbReference type="STRING" id="174720.A0A0N5B7F4"/>
    <dbReference type="WBParaSite" id="SPAL_0000198000.2">
        <property type="protein sequence ID" value="SPAL_0000198000.2"/>
        <property type="gene ID" value="SPAL_0000198000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000198000.2"/>
        </source>
    </evidence>
    <sequence length="852" mass="89172" checksum="51BF352AD59E5F81" modified="2015-12-09" version="1">MLYKNIPSPSKNCGEIEKKRLEEIKDTTSSKTMVHQIDGKGNVTTILVPKRFSRKGSPGEGDDNNTYDERKNYFPTIIDKFFLTKNLLRLSNYLRKASTFILILTLCTVVMFNSYKIMELNDRILILEEYVYDSKKTIGEKDQKIISNDFEVDILDDSEKNNSKRLVRSHRSYNSVIHNQRSYDGNKDKCICPPGPKGEPGEPWWSKSPESQKHMRAFISQIWNPKFVGKDDRVIPLDRQLRRDLRTMGFLYSPDGSRIQVRGIPGPPGPPGPKGLRGYPGFPGPIGFDGPRGFPGAPGMKGEAGERGPIGPPGLPGPQGLPGTVGDIREAISLLGKDSPYKVDKYNGNLSPPVYLTGPPGPPGPPGPQGQTGKAGPPGPKGDRGLPGFDGESRMGPKGEQGIPGKPGLPGLQGERGHPGLKGDEGKQGPRGEPGPPGQKGVQGHRGPPGFTRHTSKSDSQYVAVPGPPGPPGPQGPKGDRGDEGIRGSDGADGIPGKMGLQGPPGPRGEKGSKGDRGIKGDQGIQGPPGPAAITRSDSNSKSQTVIQGPPGPPGRDGRDGEKGEKGDSGNKGLPGPPGPQGPEGPPGKKGKRGKHGSVLEHMNEIVSKVVPVIERHLNITLFNHVKEAVKGIKSGPMGPPGKQGEQGLPGLPGPRGPQGLPGHVGEKGERGSIGAPGLPGSPGESLSYIGRESQTIIEGPPGPPGPKGDTGAPGSLGLPGPPGPMGLRGPPGSPGVEGKQGKIGPPGLKGDIGPRGNPGPSGPPGSPGERGPRGKPGEQGEKGEQGIPGLDAPCPTGPDGLPMPYCSWKPSDFDENGNVVSRVNSDKKYQTAVIMVDDDSDTSSNTDYKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B819</accession>
    <name>A0A0N5B819_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B819"/>
    <dbReference type="STRING" id="174720.A0A0N5B819"/>
    <dbReference type="WBParaSite" id="SPAL_0000219200.2">
        <property type="protein sequence ID" value="SPAL_0000219200.2"/>
        <property type="gene ID" value="SPAL_0000219200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000219200.2"/>
        </source>
    </evidence>
    <sequence length="132" mass="15530" checksum="41E8DBEA0BD6B3AA" modified="2015-12-09" version="1">MYDNSCYQRLIIMIHIYICIYKAYILRKIYLYLIIQLNFFFISRYLKMTNFNEAAEQVKHLKTSPTNDELLHLYALYKQATVGDNNTPKPGMLDMKGKAKWNAWVEKKGLSKEDAENEYISLVESLVAKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B860</accession>
    <name>A0A0N5B860_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B860"/>
    <dbReference type="WBParaSite" id="SPAL_0000223300.1">
        <property type="protein sequence ID" value="SPAL_0000223300.1"/>
        <property type="gene ID" value="SPAL_0000223300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000223300.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15427" checksum="6E125D237979CAC2" modified="2015-12-09" version="1">MIPQPMILPQHMPILNVQHGIPLQVGLPIHNSIPMPVQLQSQILSNNIVARGRPEIGGTIESIAATQNMINTPDFARVSLLNFLNDKDNFHAQGCGYDGIREYCHDALNLCKGGCRDFGNSVGIHDCRCVPLGYANILASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8G9</accession>
    <name>A0A0N5B8G9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8G9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8G9"/>
    <dbReference type="WBParaSite" id="SPAL_0000234200.1">
        <property type="protein sequence ID" value="SPAL_0000234200.1"/>
        <property type="gene ID" value="SPAL_0000234200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000234200.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="59424" checksum="16F9BA700E031E32" modified="2015-12-09" version="1">MSLNERNRSGEENDRMKQYKNAGKHDDLRRRRAECSVELRKQKRENDLMKRRMITDTDLDSHADEIEVENTVDSISNIKKESKVKITPEEAVRILSNNPTLDQMRETFEAIRRLLSRTKSPPVDEVINAGLLGALVEGLKVPDHKVQFECAWSLTNVVSGTSAQTVAGVEAGCCPLLLELCKGSDIALADQCLWAMANIVGDSHELRDYTIGLGIIDVLEYMNSHIGNYKVETVRTIAWTLSNLCRHKQPHPPLDVMKKIFPLVLSMMQFNDKAVVQDACWALSYMTDGSDDQIMIAATKECIKILVAMISSNRDSCVAPALRVFGNFATGNDYLTQLVVDSGILKKVLANLIANEKPVIVKECAWLLSNILAGNQQQIQAVIDAGLLLPILTIFKRGDFKSIYEASWAVSNLVQGGTSKQIFELWKVGGLEILCLPLRGSVNNDVFVNLLDTIYGVLNTAREYYPEVFTEMKDQIEECGGLDTIEHLQQSESEKVYQQAYRIVSEFFNDDEEDDLVDENDQQRSSFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B971</accession>
    <name>A0A0N5B971_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B971"/>
    <dbReference type="WBParaSite" id="SPAL_0000258800.1">
        <property type="protein sequence ID" value="SPAL_0000258800.1"/>
        <property type="gene ID" value="SPAL_0000258800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1654"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1848"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1940"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1984"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2154"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2182"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1664"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1856"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1873"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1940"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1958"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2156"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2191"/>
            <end position="2205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000258800.1"/>
        </source>
    </evidence>
    <sequence length="2859" mass="327582" checksum="9D3F4BBBFB1D9DAF" modified="2015-12-09" version="1">MVIGCSASKIFASSQQSQRNKSINSPLHWSKSYSPEKSVGSSPTSDSLHKSNKSIFEVSPSMSSENKSHKMRHRKRSPERREEKITTTRHLLIFAPKDSLNSTSKVEKFFSKYGYIEEVKKLDKRGQYIVSFEDIECAEKVFEKRKLDYNGEDIEVEYCYPDKSYTSSPALLSEININGKANGYEEFESNNESKHNDHHSKSRVHRSTSNSPKNAESHRNILKDKSHNKLSNSENIPTTSKIIDNESLTPQSQDSESINIMMKGILRKDVKELYTMTPVLKTYKYADIFCHSASRILYVTFPYSTIIDNEVKRQFLQFGAILDISVVKFPNNAYALIEYESMRAVAEVIEFFNEYFGKKQSDICKKYEPFKISLSKANWGRHLISNILWLEFLPSGTTLKYLTTKLKEVFKETIIDIHFHGINREAVVVFDSNESATNAFNAFKQSSIILNPSNKEGFVRTACDYSSSKNLERFIISVNKLHNTLKEVDDIVIGSDENLITFNLIQVILPTDQQQPPIDTTIKTESYPISSEEDEITTVIVKKEIKESLSASPYITSSPVSSMEDSELIKKDKHKKISPTTKSITSKSEDKKNEKSQKLLKRKLSKGSDNEGQPDYYNKEYKKSIKKCKIIGGAVPVSPVSRSSKDNTPKPCTSDSEEGSVISSRSRHSTSRHERKSKSKRREQKNSYDKHISSSHVSNVSLSSQYFGESCSNSRIHYETSSSGRRRRHYNDPPHHNDFGRHRDYGSYKTSRDDYRSYDRKDNNDRSGNYKDDRKHSRDDRGESHEKEQNKNQDDKNKKRDKKSKKHKKTRERHHIRDSDKEIQDHKKSHDHSKNSASSSSSSSSGKLCDKHLNNKNHDTSSNILNEQYNDKVTKSHTITTMKEDKRLLPIGKSHHHVKDKCKENVKSDKIKVSSKKGGQTSISGAEEISDTDEEVQNIIERRKDVPLSKNDEKVDKTPMDECEKKGEDKELDDSSLRNFNDDIPQPIEGSPSISKDSGNQSSSETPLNIYYSDEIEPTHVHPFTADKLLTDCINIANKDEKQYAIPNFISPTSTSDSIHENQDIIDEDNNAEFVHDIKEDDVSEDIIKQEYTKIDPFDVDETQLIPLEVEIHDEFGYLIYKGKKTEKSMNYVELPPLSPIPEYQLSRECEEIYSKIKQELENDYEYKNNMYELKINNKGIRKVDMNPNSRYNPEEVSELLRGREAKYEGTLDNLDGNEEIHDNEEEVCDENGVEEAEQLNPDGTKKKNTLPRFHPIKNKALAFKMYGKFISDSSAYRQKFITFMNTFSDLFNDEDHDDINIYEDEDDDSHNYPPSFICNFNNLYDVDSNDVSDEENDNEEERDDISVTSNTNDNIMIIDNNISVEVEKINNEVVVDSCDGADNEEKNNEQIIEDDIFEEDIYKHIQMEEDYLNENIINDNDNNCSMNLPNNEVSEKEQQEMIKKEFSGYDIEDIENQIRDKEIIDVNEEVKCISPSEVNEDNEDNESVSSDSQEYSFKNPTYSTNIIELVDVYQSLISESSDEVIKSDEKLQEISGNNSEKLTLVYPHYFNSKQFSNTLGVESENWKKSKIGIASNNTVISILQGDVEYKYIDENNDIHQVPNNEIRQYYDNNGVEISNDDGSSNLQNDIDEAQDRVSKCGYVKYYNNQELENDISGSERDSSSSYERYYSNNSEKSYPSIYGLPEGSVNGQSNVNDKYYLYSSEENSQETTCGEEKEGNEIYHDTRDYLVKEKSHKNVSDDHLMSSEPINEMISNTHGEEFNDSMKNDGEDVSNSNREKFDKKLCEKYDSIGDEEQYKDINMDVEVKEECDFKEVTSNNDYIDYNQINTNEEKSKDCEVNDNETHNENIKETDYGSDDEINQSSQDEEINSNDYDAYNNSSYESNESDDDCDEEHHSPTIMGIQVPPKVFISNVGVNIGLALNTVSNEFDDCKEYDGTEIDIPSLDDYDEEDENNDNISIYDNNDMVVGNDNEVKEVKDNEVEELEGEEGDDGDNDDEGEEPDDKLLLSNHVEEINDVMDDKNLISLLQNTFKRNYDGFGDDILYNEPLYKRKKLEIIPAPHSVIEIEDIVNDDGGNTLSVFVKNHNLIEEGGVDDKEGNSEIDSITSSEYHTSDLEYLSTEENIFNFDRQYLESRGMTFDNTTPTGDIFYETSSYDDNSSNSLDGSDSQYNLHQSSKMDVLSDVSPDEADRMEVETEDEKTSTDTIMCENINATECMIREATTKPSNNISIPLLATFTTKSANINKFTEIPIDRKCVKRYCIKTRLEMDDSDTEEVNYENYEIYIKDINHMEELKKSNNVVEDNEVINGDGLIRHRRNDDLHEYLARKQRVVANYENSTVLPINNDDNKNEDSNKVQLIDDNVNINEESNKKDVIVNNNLVAKGSDNICNLVSKKESNLEQMLIVEAPDKEAIEALNSLSYLDEKEINEESIDDTSFLLDVIENPSDFGDSIGSELLEDDIEKLLNDEPTSPKKIKTEYVERSDINNDTLINGYSDKEKISSSEGNEKDNIIKEPEMNVDEIEVKEESIEMKRNNDMIIIGGEVKENEKENMIVEVIEEKDEENKMIEEEEIKFNEGTLTIKTDSLSSSLIEPLINNINDNVLLSSLKNTITENEENVVECDIENNKTQEKNECSGKENIIIQQNGYTSLPLSDKGNNYKLYVNTFGITFVNGTVLFELANANCLTSCPRICLQLKKWLCKLNLFYISGMKEILNDFIVTHTHPNRLNPKNRNIRISKKIVSKEYYENIKKTLLDSSPNVLNLICGASGYNKEDYEVEETRLNNILNYCKKNGLYSGLLWQSAVSDYVAFFIPSCDILDDQFKSAQPQAFCKVKTGSMSYFYISIAPANLFRSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9J4</accession>
    <name>A0A0N5B9J4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9J4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9J4"/>
    <dbReference type="WBParaSite" id="SPAL_0000271000.2">
        <property type="protein sequence ID" value="SPAL_0000271000.2"/>
        <property type="gene ID" value="SPAL_0000271000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="46"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="245"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000271000.2"/>
        </source>
    </evidence>
    <sequence length="444" mass="49982" checksum="F28E79CCDE891B00" modified="2015-12-09" version="1">MREVISVHIGQAGVQIGNSCWELYCIEHGIQPDGRKKEDSPIDDSFKTFFSETVARKYVPRAIFVDLEPTVIDEIRVGEYKNLFHPEQMITGKEDAANNYARGHYTIGKETIDNTMDRLQRVAENCDCLQGFLVFHSFGGGTGSGFTSLLMERLSIDYGKRSKLEFSVYPAPQVSTAVVEPYNSILTTHSTLEHSDCSFMVDNEAIYDICRKNLNVARPSYENLNRLISQIVSSITASLRFDGALNVDLNEFQTNLVPYPRIHFPLATFSPILSTEKAYHETLSVMDITNQAFQKDNQMIKCSMEHGKYMAVCLLYRGDVIPKDVNAAISTLKTKRTIQFVDWCPTGFKVGINNQPLVEVPGGDLAKVPRSVCMLSNTTAIVEAWSNLNAKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYHEVAIDDNDGGDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Q8</accession>
    <name>A0A0N5B9Q8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Q8"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Q8"/>
    <dbReference type="WBParaSite" id="SPAL_0000277400.1">
        <property type="protein sequence ID" value="SPAL_0000277400.1"/>
        <property type="gene ID" value="SPAL_0000277400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000056">
        <property type="entry name" value="Zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF133">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="150"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="485"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="757"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="485"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="600"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000277400.1"/>
        </source>
    </evidence>
    <sequence length="895" mass="100246" checksum="D942809BB1057D67" modified="2015-12-09" version="1">MKAYTKPSSYINNYYLLSLLFLCILPTESLRPFIHRRFQDDTAPKDFKDYKLYRINPRNQENLEYLKDLFAHDSPYELDFWQPPTHIGGLVDVTVNPEDAKIFGRDLDSKQLDYSIAIDDLQTAINEERNVNTSSDPLYMKDSGYLRLDKYNTFDNIEDYLRKLELDNPELVNLIEIGKSHENRSLTVVKIGSKRPYGCKKLGFWIDAGIHAREWIAPATALVFIDKLVKGYNDDAVIRNYLDNIDFYILPVMNPDGYVYTHTSNRMWRKNRRPAQCKKNYFHTICCGGVDLNRNFDWFWASSGSSSDLCHETFHGSSAFSEPESRAVRDFLEKNAMKSFISLHSYSQLWLIPYAHRRRSYPQDYATNLRPLALRATKAINNLHGTKYAVGTGADLMYEASGGSQDYAKGVLKIPYSYLIELRPKNSMMGNGFLLPESEILYTGEETFEAIKVISDELIGQYGKPKDSACKVKLIIPSKKTTTTEVPTTTTTTVPTTTEEITTTTEEPTTTESTTTTTTEVPTTTTTTEIPTTTTTTEVPTTTTEIPSTTTTEIPTTTTEVPTTTTEIPSTTTTEIPTTTTTEELTTTEELTTKEDKTTSVEAQSTESESASTESSSASESNSSSSEEASTELATSPKPVIEVKSYSTEKVTEKSDEETTTIATTEGIKATTDGVEKVETQKTENPITDVPENNNNNFETTEMKNEITTEKVIDESTIVPTTENIPKIRKVIENQVKKVLKNIEEVDKEDKTNEVLQSTTIASKVPDEESSNAEHSFLGSSTQKSSTTTESQGQTEAKNIIVEEETTPEPSTTTTTTTTTTPEPSTTTTTTVAPSSTKKYVVKSKKITKIPVKALKKPGHCKDYGSYCKWWKIHDLCDKPRVRQLCSLSCLPECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9X8</accession>
    <name>A0A0N5B9X8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9X8"/>
    <dbReference type="STRING" id="174720.A0A0N5B9X8"/>
    <dbReference type="WBParaSite" id="SPAL_0000284800.1">
        <property type="protein sequence ID" value="SPAL_0000284800.1"/>
        <property type="gene ID" value="SPAL_0000284800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="9">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000284800.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31233" checksum="9E7BC1EA03D247A6" modified="2015-12-09" version="1">MNETATISAPNRDILRTGEDVISEDEARKRREQLNRRPSYRMILKDLETVTDKSISKKDSTESDIVVVTNNASKLSPQNIPTLPTPVPVLPLKMDGTNSYVSPIVSGPQQQCTSSSTELRMPSLLSDPNVVTGSSLNIIPPSSIPTSVVSNPTGIMLPLNADLLHLKNINDSLALGPFTGVANNNGDWQPGLLNYNSPSNHINSGPASASSKSSIGIPDGDDSTKKRQVRLMKNREAAKECRRKKKEYVKCLENRVSVLENQNKALIEELKTLKELYCQKGKPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA01</accession>
    <name>A0A0N5BA01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BA01"/>
    <dbReference type="WBParaSite" id="SPAL_0000287000.1">
        <property type="protein sequence ID" value="SPAL_0000287000.1"/>
        <property type="gene ID" value="SPAL_0000287000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="2107"/>
            <end position="2238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000287000.1"/>
        </source>
    </evidence>
    <sequence length="2340" mass="273740" checksum="A536575DDC2886B1" modified="2015-12-09" version="1">MDHSGLDHNYHGSSHHSTIRENYLSEKSAKWKQLQSKRYSEKRKFASVYDGVKEEMPPEHVRKIIRDHGDMTSKKYRSDKRVYLGALKYMPHAILKLLENMPMPWEQIRDVSVLYHITGAVSFVNEVPKVVEPVYIAQWATMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLDAIQMELDPEEDGVVAEWFYDHKPLHKELRFLNGPSYKKWQLTIPVMSTLYRLSDQLLSDLVDDNYFYLFDLKSFYTAKALNVAIPGGPKFEPLVKHLNNDDEDWNEFNDINKIIIRCPIRTEYRIAFPFLYNNLRNVLPVVASWYHTPNVVFLKPDPALVQDLPAFYFDPLINPIVSRDVKRTEEVFDIPDEDEDDFCLPDDVVPLFSEAPLYTDNTAMGISLVFAPRPFNLRSGATRRAMDVPLIKSWYREHCPAGMPVKVRVSYQKLLKVFVLNSLKHRPPKPQKRRYLFRSFKATKFFQQTTLDWVEVGLQVVRQGYSMLNLLIHRKNLNYLHLDYNFNIKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLNNVDAYQLADGLQYIFAHVGQLTGMYRYKYKLMRQVRLCKDLKHVIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRFSKGVAKTVTKQRVESHFDLELRAAVMHDIIDMMPEGIQQNKSRIILAHLSEAWRCWKANIPWKIPGLPTPLENMILRYVKAKADWWTNSTHYNRERVRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFSPIPFPPLNYKHDKKILILALEKLKESYSVKNRLNQAQREEIALIEHAYDNPHDALSRIKRHILTQRSFKEVGIEFMDLYTHLIPVYEIEALEKVTDAYLDQYLWYEADKRRLFPNWIKPADTEPPPLLVHKFCQGINNLTNVWETKNGECNVILESKLEKMYEKIDLTLLNRLLRLIVDHNIADYMTSKNNVVINYKDMNHTNSYGIIRGLQFSSFIVQYYGLVLDLLILGLRRASEIAGPPQNPNDFLSFQDVETETCHPIRLYIRYIDKIWMVLHFDADLTKDLIQRYLTEYPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSITTIEWENSFVSVYSKDNPNMLFDMCGFECRILPKCRMETEDFTHRDGIWNLQNEETKERTAQCYLRVDDDSMQKFHNRIRQILMSSGATTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPARFPPVVFYTPKEIGGLGMLSMGHVLIPMSDLRWMKQTDSGGITHFRSGMSHDEDQLIPNLYRYIQPWEAEFVDSQRVWAEYALKRQEANAQNRRLTLEDLDDSWDRGIPRINTLFQKDRNTLAYDKGWRVRTEFKQYQILKLNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLYKGTYFSTWEGLFWERASGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESMVMDLCQVFDQELDALEIQTVQKETIHPRKSYKMNSSCADILLMAQYKWPISQPSLLGDTKDISENKTMQKFWIDVQLRWGDYDSHDIERYSRAKYYDYTSDNMSVYPSPCGVLVAVDLAYNLYSAFGNWFPGLKPLIRQAMAKIMKANPSLYVLRERIRKGLQLYSSEPTEPFLTSQNYGELFSNQTIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLSQLAKWKTAEEVAALIRSLPIEEQPRQIIVTRKAMMDPLEVHLLDFPNIVIKGSELMLPFQSIMKIEKFGDLILKATEPQMVLFNLFDDWLTSISSYTAFSRVVLIMRAMHINPDKTKIILKPDKTSITQPHHIWPTLSDEDWMKVELALKDMILQDYGKKNNVNVNSLTQSEVRDIILGMEISAPSKQRQQIAEIEAQTKEQNQLTATTTKTTTKHGDEIVTVTTTNYEKATFTSRTDWRVRAIASTNLHLRTQQIYVNSDDIRATGYTYVLPKNLLRKFIVISDLRTQIAGFLYGCSPPDNPSVKEIHCIVMPPQWGTHQLVNFSSHVPRHEFLRDLEPLGWIHTQPAESSQLSPVSVVTHSRILSNNTEWDGERTICMTASFTPGSVSLASYKLTPSGFEWGKQNLEKGVNPKGYTPSHYEKVQMILTDSFLGYFMVPVGGIWNYNFMGVRFEAAMEYDLILGNPKEFYHEDNRPLHFHNFKVMEDEKGVCGADNENFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAS0</accession>
    <name>A0A0N5BAS0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAS0"/>
    <dbReference type="WBParaSite" id="SPAL_0000313450.1">
        <property type="protein sequence ID" value="SPAL_0000313450.1"/>
        <property type="gene ID" value="SPAL_0000313450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000313450.1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7778" checksum="5BB79EDB2B7055DB" modified="2015-12-09" version="1">MKLFSYVNETVYIKERGEYITECCRGPRLLYISSFIRFLKNYQIPLTWLDILYRHTEYYLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBH4</accession>
    <name>A0A0N5BBH4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBH4"/>
    <dbReference type="STRING" id="174720.A0A0N5BBH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000338300.1">
        <property type="protein sequence ID" value="SPAL_0000338300.1"/>
        <property type="gene ID" value="SPAL_0000338300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862:SF0">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000338300.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37207" checksum="2BC713470D49AF5D" modified="2015-12-09" version="1">MEKSLVYAGIEGGATTLQLMVMDENGNILGEWQKEGFNFAITGIQKTAERICSYIEEIKKENNLLFSFAALGLGLAGAEDNEVNDKLVKHLTENYSHISSYFYATSDSIISIASCFKESGIVLIAGTGSSCRLLKRNGIVHYVGGWGHLISDGGSAIWLSINAIKLLFDLEDGLKEVQYSHETLKKIILNHFKLTNHVQLIDAIYGVNFNKANVASLCQILALQAPTDPIVEMLFYECGQELGKHLVAIIKNVDKEMLNNIPVLIVGSMFKSWNLIKKGFWLVIEGNQKKYGYTKITLYQQNSSPAVGAIRLATKNAGLKFEKEIPLKIFDERTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBU9</accession>
    <name>A0A0N5BBU9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBU9"/>
    <dbReference type="WBParaSite" id="SPAL_0000350325.1">
        <property type="protein sequence ID" value="SPAL_0000350325.1"/>
        <property type="gene ID" value="SPAL_0000350325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000350325.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8020" checksum="3038DE616F52FE68" modified="2015-12-09" version="1">MEHLPYLWCYCCKKDIPFIHSDNINQEQKSSIHIYQEATSMDDTYVHGSEKIFISLIVRILQIYIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCH4</accession>
    <name>A0A0N5BCH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BCH4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COPINE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Copine"/>
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        <property type="entry name" value="VWA"/>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6687"/>
            <end position="6880"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
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        <location>
            <begin position="1395"/>
            <end position="1406"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="SPAL_0000372100.1"/>
        </source>
    </evidence>
    <sequence length="6919" mass="786872" checksum="D2EB2F3B40A15175" modified="2015-12-09" version="1">[encoded data, 6919 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCX1</accession>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            <end position="151"/>
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        </source>
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            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
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        <source>
            <dbReference type="WBParaSite" id="SPAL_0000386550.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19154" checksum="BA9F2369A1006F56" modified="2015-12-09" version="1">MAKRELPKEAYCETEISDEEYYFDSLNIDSDIESDNDCSDSSSDIVPVKRRLSQLVMSSDSEVEENDENENSNINEFTTWRNIVGPNVPVHCTEPIDFFRLFFTDTLLETIVLETNKYAKNKIEQQRLSDRSTWNNWINVTKEELAAFLSVIXXXXXXXXXXXKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Intestinal threadworm</name>
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        <lineage>
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    </dbReference>
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        </source>
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            <dbReference type="WBParaSite" id="SPAL_0000387750.1"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD72</accession>
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        <submittedName>
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        <name type="common">Intestinal threadworm</name>
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        <lineage>
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            </authorList>
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        <property type="gene ID" value="SPAL_0000396200"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
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            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000396200.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20986" checksum="3B7C1DC6C93AD864" modified="2015-12-09" version="1">MYNKSYSLPGDINNVTSDRHSVSEKMRVNKVTITILLLYLLTSVITLFLHLPISTITLIIPVLAVPFTVWAIKYDVRPARRISLNSTCTCLCLKLVSIVAYYVIFERNKHVSKIKEANYARRVALLDEKNKEYDMKVIFMAGIILGETLIFILYAFIQWHRTAFKKNKKRNRIDREVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE22</accession>
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        <submittedName>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000424900.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="65241" checksum="F7D82C7EBC13F2F8" modified="2015-12-09" version="1">XSPPKRAPTHTRSTYNLRSNKDNMEKGISIGAVLSPSSNDSFKNSEEDISPHISRMERKFRLLGLEAEMDKIDALFLSLSPGITEAYTAEFGDPTNYTTFVNNLKKRYDGRQTRLWIETTLADMKLNERSSKFEEDLGYLCSLVRKTMPNCTDKQRLEEMKRRIHTKLTPHSDLWKFVIMSSYDNESDLVREVASYAKLLSPLQAPEDKVFKTLPPKEKIKGNCSIHPRAPHDDSECQVQKNLKNQPFQSNFVKKEIENPPSQNFILKQSSNIRKADIRIPVSFVDPQEERAVSAIAYVDGGAQVSIMSSKLAKRLKLEILPSKYKSLRGFTQHCQETSGSVNVILCLSNLQIQCSFEILEQIPDKLSEAFIGNDVLAFVEASVIYKEPKGIQINDIFTPSVCPPEPKPTEPSISRIEANNHSVKALRIEGSPKSRPSRIPRLKRLLSPNQQQHRYPKNQLPIQSTPQDILEIRNTSTTTNITISNQIKLGGIIGPKIYSHFRPPPLKEETPILAEEKCIKLAERFYTINKNKFLLKDTGPCIVNSVTPYMIQYHKSEKSRKVSRAHPQHVETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE36</accession>
    <name>A0A0N5BE36_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease K12H4.7</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE36"/>
    <dbReference type="WBParaSite" id="SPAL_0000426300.1">
        <property type="protein sequence ID" value="SPAL_0000426300.1"/>
        <property type="gene ID" value="SPAL_0000426300"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894360" evidence="6">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000426300.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29034" checksum="3811652877EC5E52" modified="2015-12-09" version="1">MFKFGFLLLGFFILITSSWVSSKSPRKIPGALRFLNGRPYAGFRGHRFNIPKEKREAFEKKYNEADYEFYFTQILDHFSSNDSRTWNQRYFFNDEYYQDGGPQFLNIGGEGPESYMDVTYPELPFIMWAKELKAMVFSLEHRFYGKSRPFTSQTVPALTYLTSRQAIEDIANFIRSMNIKKNIKNPKWIIFGGSYSGALSMWTKRIHPEIIHGSISSSSPAQVTLDFYKYMETCEASFYKNGSYLCGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE64</accession>
    <name>A0A0N5BE64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallothionein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE64"/>
    <dbReference type="WBParaSite" id="SPAL_0000429000.1">
        <property type="protein sequence ID" value="SPAL_0000429000.1"/>
        <property type="gene ID" value="SPAL_0000429000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000429000.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="8580" checksum="6CA886BF49B768FE" modified="2015-12-09" version="1">MVCRRGQCFCCGTCGCSCCGSSGCRCTCCGTSGCKCCSGLGCKCCSASGCKCACCGTGGCTCCGPSGCKCCKPSGNVKIQLTTACECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE82</accession>
    <name>A0A0N5BE82_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE82"/>
    <dbReference type="STRING" id="174720.A0A0N5BE82"/>
    <dbReference type="WBParaSite" id="SPAL_0000430600.1">
        <property type="protein sequence ID" value="SPAL_0000430600.1"/>
        <property type="gene ID" value="SPAL_0000430600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894447" evidence="6">
        <location>
            <begin position="19"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="51"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000430600.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="65233" checksum="2245BE1D391F97ED" modified="2015-12-09" version="1">MIIKIFTLFLTFFHGTIHQNLNTSLGTVKVGIVLPNTDPTLVYWQGYPNSAAAVTRALEVARENNTLLERVNFEFVWTMNECIASEAAGQLFNLTNVQKIHVLFGPPCYGTANVAMNIATYYNLPLYLFGTSSLQEITEISSYKVVTSVMPSYSDFVIGLARLLIKFEWTNVAIVAYESADKLGRCGIFYNQADQRITQGFEQINVVYQRNMVNFSPDNLKKVTDDIKKLTRVIVICMDEIDKLRSFMLAAYDNGMNTSDYVYINCDVDMDIYVNEENKNAMVDYKLPPDGRDEEALSMYKWMFHLHFSALGGISSEYNNFRVSMPKLMREPPFNCTTECEKYNASSAYAPYLFDSAYLYFISLGLALNSNGTNPNATAIADNGTLVTTYSTGVFNGMTGAFQISKNLTRDSRLSFSTYFNNGLNVTRWIYFIVVGDDAEFNISFTDPATTIFAVRGGVTPLNVPKCGYQDEFCQPSFIEKSPVGFAFIIVGGVIIFVVILVLMIYLYIMKKKEEEKQNELWRMYFGSVIKYSDYKGSIVQLQSKRSLLSTSQTSTKQSFKDKAEGKHQLYVLHTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEK2</accession>
    <name>A0A0N5BEK2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEK2"/>
    <dbReference type="STRING" id="174720.A0A0N5BEK2"/>
    <dbReference type="WBParaSite" id="SPAL_0000442800.1">
        <property type="protein sequence ID" value="SPAL_0000442800.1"/>
        <property type="gene ID" value="SPAL_0000442800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000442800.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30175" checksum="F0BB838375EB48FA" modified="2015-12-09" version="1">MKFIETIRLHDINIKTNDLVNCENGKIVQLSNGNYVEAEFLIFLKNNNSIDIYYHKQNFDEKKVISKELVVNVNFLNRLNVDSFEVLLTKGILKISIISGNEMRIVFASIENNSIKKVNKFESTLIHGKYQGYTKHSLLVDNQKGSFILATGRIVKFKNNFLSNGDMIYMDPIGNINKVTVQYSGNNCKFIHIHYENVAEICDNGIIRSRKFSLKMLRKDENILSYTNKINLQLPPNKLESFGWMEHFISKQNRISVTIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEQ7</accession>
    <name>A0A0N5BEQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein Vpu</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000448000.1">
        <property type="protein sequence ID" value="SPAL_0000448000.1"/>
        <property type="gene ID" value="SPAL_0000448000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000448000.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12089" checksum="DB7A22C2023A9AA2" modified="2015-12-09" version="1">MAIADDLEVIIRYSRTEIFLLIILVVLYFDIHYFTRTRAVKIIEELDKMDRDLESGKNIIINFLDSQQSVNAAPSEVPSMVDPAVRSSVASGVSTHQSADPSAYKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEU9</accession>
    <name>A0A0N5BEU9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEU9"/>
    <dbReference type="STRING" id="174720.A0A0N5BEU9"/>
    <dbReference type="WBParaSite" id="SPAL_0000451800.1">
        <property type="protein sequence ID" value="SPAL_0000451800.1"/>
        <property type="gene ID" value="SPAL_0000451800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000451800.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="62099" checksum="30DED193DDD438E0" modified="2015-12-09" version="1">MVLLRRQRKVLKTINEEGVRNIRLGELSGDDFILEFSSTTFTNVIPDYEVMEDKIDEVTDVYDEKILDYCEAAQRMLKIQRKSLKAAVLQKNSKVKIPKTPKRGKNVSKIDKMHETIETRKDRMTKKNLFVNSNLSDDATGTSTRGIVVTNKACGTIGIHQNAENIPTTPHDILAASKRKRNTSERAMLLVQQGSSLRRADMKKKDLLKEKAEKAKREREERARRVEERRRLREQEREEILKEKREKEERMKEFRNHITKPGTPNDKCFKTPTSTVSRPKIPIKDIVDVSPIQPMEGIETSTSSYKTIVDKSCGSFELVYQTPEVARKRKNFSSRRSDSSPSPSRKNHRICYADDLTPEVTFNYCKDKTLCSDAVEQNQFRDFEKRMESIQLTNIIASPSMNNTVFNTSLTRDVQYEITPAKVPLPSTVDDYNIADLSEGDGTDDEDNPRKTIPKWAHMEHLRPALKEQHKKFKSRPLSEILNIFGKVNEFKVEDIFKNKEYVRSSSAFWSSPIHNPTHGRAIYQQLNGSVVDSSFFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEX9</accession>
    <name>A0A0N5BEX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000454900.1">
        <property type="protein sequence ID" value="SPAL_0000454900.1"/>
        <property type="gene ID" value="SPAL_0000454900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000454900.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20591" checksum="1292686C556DD3CC" modified="2015-12-09" version="1">MMRSNSYFACVLLIRILILIFLVVSSVLILVGPGLCLLYKPVDAVEEYDCYSFSVFDWYSFTNYAYFQIAVIIVPLCMGTFSLIAIASIKCCDCHWPRLRHSMIAGTGIIVYTLAGVLETLVCFNILDYYDFYGIKTYLIESKKIFVKGYLASAIFLFLSSFLAMVDACLLDARRFNIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF63</accession>
    <name>A0A0N5BF63_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF63"/>
    <dbReference type="STRING" id="174720.A0A0N5BF63"/>
    <dbReference type="WBParaSite" id="SPAL_0000463100.1">
        <property type="protein sequence ID" value="SPAL_0000463100.1"/>
        <property type="gene ID" value="SPAL_0000463100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14699">
        <property type="entry name" value="bZIP_Fos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000463100.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44619" checksum="FA8294F67DB6EE1C" modified="2015-12-09" version="1">MSKRTSSVISDGQSFSNDDYNSAESSPNQTGDFNGGSQSISGQRKRYRHFSGSNDQLRGSNKEPSEEELRKKENRRQRNKIAAAKCRQKRIDQLKSLGEEVEYLKIRNKAVEAANLKLFEEFEKLERILREHRCHMSDGDRKALEAIFSNPDFKKLADELRSGTNTKSESLSEQLQKAVTENSTTDKQDQQNAMNSNISVHNINENGEHSKNSNHNNNISLNVKQENVSSNSCNGEQIYNSSKESLYDRDFKATSIESSRTKIDQVLSHTTIADSYDRNDVKDENNKNHHGSKIPTRQSSTTLETPEKKYIQSLPRPSFFPEKFSTTSVELPKDTIKDESNPFFENNFQSDEKVNLFTLGNDVTGLTPIANNIQYPTLLDTPTPMGDKEFQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFH5</accession>
    <name>A0A0N5BFH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin family repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFH5"/>
    <dbReference type="WBParaSite" id="SPAL_0000474100.1">
        <property type="protein sequence ID" value="SPAL_0000474100.1"/>
        <property type="gene ID" value="SPAL_0000474100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF8">
        <property type="entry name" value="PROTEIN CBG16761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000474100.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44827" checksum="DC232E2C6E543033" modified="2015-12-09" version="1">MGEDDYSSETTGGQRKKWTLEKLRGGESILPQQAGSNKFDSQRGMTAPGMPRWNVTKDKSLGYIEPDRRSENVLRAQCGTNQYATQAGQTAIGSGRNQVPKVVYKKEWETIHDKEGEKILPKQSGDYGYASQAGCALAIGTHRNQVPNITGRMPNDRRTHGVLCYQYGTNIFASQQGMNAPPGVGAVRQATINIEGLGFTEDNLRKGTIDTPWYSGQNKFATQAGSGGFMKVRDVIPHTQGGKEIDEEKKRLSDGIVPLQSGTNKLASQRGMTGFGTPRNILTRNGWKKEWIEEYEAALKEWEESKPPGSASSVDPFGHYKKKFEERELSKASSGKSLNSVEKQEEKIEQQEEKEEENHEEDVEEEEENDKENEENQEGEEEIDEEEEEEYEEEEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFR7</accession>
    <name>A0A0N5BFR7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFR7"/>
    <dbReference type="STRING" id="174720.A0A0N5BFR7"/>
    <dbReference type="WBParaSite" id="SPAL_0000483200.1">
        <property type="protein sequence ID" value="SPAL_0000483200.1"/>
        <property type="gene ID" value="SPAL_0000483200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012204280" evidence="9">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000483200.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20595" checksum="FB434E34BD7CE2CC" modified="2015-12-09" version="1">MVRYILISLIIKILTINDNVEVETTVVLSNKTSNEECYAVSESKNPQGPLVPCNFLDTRFVECLRLISKNHTKDALCKKDVRTGGMAKVNVTCSVLPCIECSGNREFVREVSCVAYSGHYFLTTLLYSVFLGFFGVDRFCLGYSTAGVGKLISFGGLGIWWLIDIYLLVSGNLMPADGSMWEPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGI9</accession>
    <name>A0A0N5BGI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000509366.1">
        <property type="protein sequence ID" value="SPAL_0000509366.1"/>
        <property type="gene ID" value="SPAL_0000509366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000509366.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9138" checksum="CE919775D18E8D9C" modified="2015-12-09" version="1">MREQNEEWTTPESKVSKTFAVPFFGFLFADVMKRKTKTWGIYLRKGLRYCLNISGDRYLERGIDTYLDIKDQRKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHC8</accession>
    <name>A0A0N5BHC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piggybac transposable element-derived</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000537025.1">
        <property type="protein sequence ID" value="SPAL_0000537025.1"/>
        <property type="gene ID" value="SPAL_0000537025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894520" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000537025.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14442" checksum="F35943DD752CD8C2" modified="2015-12-09" version="1">MKWYLRIFFFVVTQAAVVNAWNIYQLNSDSKIKIVDFKRQIVASMLKLERPKMSRVHHILETVTGKGRIPRRRCVECYQQLSKKFGSNVARQKAKQVKTKCSKCKKYYCLECFQRFHTKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIQ0</accession>
    <name>A0A0N5BIQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BIQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000583000.1">
        <property type="protein sequence ID" value="SPAL_0000583000.1"/>
        <property type="gene ID" value="SPAL_0000583000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="99"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000583000.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28853" checksum="6DE09FBDA28991C5" modified="2015-12-09" version="1">MDSPYLYKLLYSDKNQIDNLENSITQLPNLDATQDDNLFQNLSPADLSIDKVNLNPVDLPPLTPLDSSNSVSSLSNVNNVPSYVKLDSQLSVEQYIKENDISIICSTDGSCESGRGLAYYIKYPKGEIEKSFRAGNNSSAQYLEITALHQCLVELSELNNKNEFPSSSKILIITDSDYGARALSTDLKKWLSCGFQKTDGKKLTHENIIKSSWELIVNLDSTIIIGKVPGHKGIILNEKVDTMARRAAVRPVKQAVSFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJJ1</accession>
    <name>A0A0N5BJJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BJJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000611700.1">
        <property type="protein sequence ID" value="SPAL_0000611700.1"/>
        <property type="gene ID" value="SPAL_0000611700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000611700.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9942" checksum="0727FE6B5743250F" modified="2015-12-09" version="1">MHHQPLNHERAINLSILIVSGPGSTPGGALPSIPLSFSFATILPPEPKDFRFREDLPFPLPTSYLNLKIFNPNINNNIWLSFFVTTSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJJ3</accession>
    <name>A0A0N5BJJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BJJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000611900.1">
        <property type="protein sequence ID" value="SPAL_0000611900.1"/>
        <property type="gene ID" value="SPAL_0000611900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="645"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000611900.1"/>
        </source>
    </evidence>
    <sequence length="1476" mass="168425" checksum="AADBF2120BDA6A01" modified="2015-12-09" version="1">MVKRRKIQDNESSQGDEDRCNYQLTNSNTNTANGGEDGGQHQAEDISPRHRKKSKKSTMLTWGDREKSKLDIWLDHIKDRLRRFSRGQSTLVSWTLIPDEEVRLYAEAISGKELLAKTFKENISNFLQKERLSYIQNLRELSPKASRRNKSEVERRISLEYPNHYQEFVDKVQDINPVETPRVKRPCIKKTPERDNMTVTQPGLIPNINNELAEAIQDDTQQKDKPEERFDLVNSSSQEISPEIRRPPAKRRRDNQQSPVFLNISEELTEAPTQASTPTPQFENELNDTSLLTALNISQENNHSNQSGEGIPKERVYKSRVFPEETTLSSQDKAKLRRKIREGITFGHVLPQETKPKRVNPLLEMNTQQRFKYFLDKKSLPVCKRWDVNRRIPIDEINHLGYNELQKLIEKLESPTCSQNEYIQVNRAWPKIATAMMHTAQSYSGTNKSDFNLKQSKIVRRKKRMIRLSQTLHKAWKNRLNPSGKDKKLLAKMRIDAKEKHLNVKGLLKKVREEITFLEHKEKKEAEKAEGRKIRSMFDKSGSIKTVLQAGKTGKVPVKEKEAVKFFRNLLSQKITPPQLAIDEWVKSWEGRPITHDLDQVGQFLKSKLKYSRPFKTPGPNQVHPAAFKRFDSLARLLLAKVTGLLSGKFSLTEEDMTAQAFLLPKTDPPSNDPNDYRAINCINADIKYTNAVAYEYIYKNCFQYIATNQCAAFKGIPGTLHAMMVNYAILEQNPKATSVLYVDMKKAFDSVSHTAMKKAVNALNIPKSIKKHISGMLGLGGFTISNIIKDRRMKNNRVEIKQGIMQGCALAPCLFVVGMDIISYQLNKESKLVIGKSLTSLPEDYVDKLNHKFQNEQNTRIVVESARETDSDSVHLIKRADIESTNHISFVDDVKLFAKDNATIKKLKEIFESVALQLGLHVNAKKCGVLYNKKSDDQVRLEDIDELADCYKYLGIPELGRGISIDQLEKNLIKKITGSVSQVFKTKLNLGQKIKWYNSSIAPAVGYAVTHAFPAVRARSLPSLCQRLDCLVIKLLAGNISDSEQIAVRQRTTIISRLYCNPDSGGLGLKPLLCVAYESLTRHVANLWMNPINERVKGLNIQHELKGGKKTPLKQFDDLLKKILKVKCTYTKSGIILEGVYYDDVNGFTKAVTQLIKNWNNSLWYNKWIQKLDYAKAYHSLGLKMPWLKKAAVSDLEANLVMSSQQQSLPGLNWHINKRNNIFNKKCSLCQKVLNTSHILGSCDSKIARLKYTARHDAVLAAVTNSILKCLGAKYMPLQELRLLRENQIIGKDWSIGFDVPQLVEVGQIRENYEQVFGNENGCSNPVKKIAHNRPDLVLINHKLKKVILLEVAIVGNPRLIQQQVEIKNVRYMKNSQEVIGPDNYLLVNRAFNMSDHFKKKYGSEYEVEFVPFILGAYGEICPGFQEVLMKPLTVLLKQQHMKAMIANASRTAVVNTAYNLRFWLSIMESEVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK76</accession>
    <name>A0A0N5BK76_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK76"/>
    <dbReference type="STRING" id="174720.A0A0N5BK76"/>
    <dbReference type="WBParaSite" id="SPAL_0000634000.1">
        <property type="protein sequence ID" value="SPAL_0000634000.1"/>
        <property type="gene ID" value="SPAL_0000634000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000634000.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49819" checksum="554D8B1FCFC2F787" modified="2015-12-09" version="1">MREVISVHIGQAGVQIGNACWELYCLEHGIQPDGTMPSEKTSGTVDDSFTTFFSETSQGRYVPRAIMVDLEPSVVDEVRSGTYKKLFHPDQMITGKEDAANNYARGHYTVGKEIIDQTMDRIKRVADNCSGLQGFLVFHSFGGGTGSGFTSLLMERLSVDFGKKAKLEFSVYPAPQVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIARPSYSNLNRLISQIVSSITASLRFDGALNVDLNEFQTNLVPYPRIHFPLATFAPVLSADKAYHESLSVMEITNQAFQPENQMIKCQTHSGKYMAVCLLYRGDVIPKDVNAAIAQLKTKRTIQFVDWCPTGFKVGINYQPLTTVPGADLAKVPRSVCMLSNTTAIVEAWARLNNKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGADSNDGGEDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK78</accession>
    <name>A0A0N5BK78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Stress-associated endoplasmic reticulum protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK78"/>
    <dbReference type="STRING" id="174720.A0A0N5BK78"/>
    <dbReference type="WBParaSite" id="SPAL_0000634150.1">
        <property type="protein sequence ID" value="SPAL_0000634150.1"/>
        <property type="gene ID" value="SPAL_0000634150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000634150.1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7019" checksum="11F5CA84592DBE36" modified="2015-12-09" version="1">MAPKQRITAANNAFHKNINNRGNVAKSLKPQEDKYPVSPMLIGFFLFVVCGSAVFEIVRTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKM4</accession>
    <name>A0A0N5BKM4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ribonuclease P/MRP protein subunit POP5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKM4"/>
    <dbReference type="STRING" id="174720.A0A0N5BKM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000648000.1">
        <property type="protein sequence ID" value="SPAL_0000648000.1"/>
        <property type="gene ID" value="SPAL_0000648000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414:SF1">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000648000.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16756" checksum="9D911E6266C35F78" modified="2015-12-09" version="1">MVKLKHRYFLIEIVFEDNYSKATQYDIIKEIKDKVLELYGDYGLGTLNSTFGVSVSEVGKGLIVVKVGIESVNFLKGSIPFIVKAGKASCVLKILLEAASMRSINKKMVRINLDQLYDQLNNAKSFKERMEVQEGIVKVSGSNAERVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLV2</accession>
    <name>A0A0N5BLV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLV2"/>
    <dbReference type="WBParaSite" id="SPAL_0000689800.1">
        <property type="protein sequence ID" value="SPAL_0000689800.1"/>
        <property type="gene ID" value="SPAL_0000689800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38613">
        <property type="entry name" value="PROTEIN CBG03211-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38613:SF1">
        <property type="entry name" value="PROTEIN CBG11062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894592" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000689800.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38438" checksum="7AC798A8FB614A42" modified="2015-12-09" version="1">MKPFWSLLFICYISTITADESSDEEVVNIACKRNPSLRFCRTPQTNDIRKSEPNFTDKDELIIPPPVPKDVEIQLDSYEDDVEQAKRAKKYHRRLQKVTPPPARQNILFTILPTLQKKSSNYCAINEYTFATTCAPGKKLRYDLQLFCDEFSRTCGIPNINEYESKRVDKEYYPEGYGQKQKNGHFGVGNSFAMGIGVIPGMTLVGSRGAEVGKLPFLDSIGGMMFNKGTDIGLLGERVGRGPERTMDALKSGIPSFGLNPDTKAADERAQNAALRSLGIPPIPGLAKALGALNKNGKKRKFNGFEPGYDALNKHAIIATGKSDGNNVNLPGGMGTVEYMEGVGMGIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM35</accession>
    <name>A0A0N5BM35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">FoP_duplication domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM35"/>
    <dbReference type="WBParaSite" id="SPAL_0000252800.1">
        <property type="protein sequence ID" value="SPAL_0000252800.1"/>
        <property type="gene ID" value="SPAL_0000252800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000697900.1">
        <property type="protein sequence ID" value="SPAL_0000697900.1"/>
        <property type="gene ID" value="SPAL_0000697900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000252800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000697900.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23232" checksum="35573BA9BDCC056E" modified="2015-12-09" version="1">MSVKSEQFRHLSSGSSRARKPSQSGSQRKGRRSRGNGRGVQSGRRVQHGNRVQPNRRVQNGKKLKPGRRAQSGKKVRPGRRAQSGKEVQPSRRVQHGKRVQSSRKVIGRSSGRGSRSRVRPSGGVRESRQGYRGKGSGIRSLSEAGNKLLQEEAEVEDVAKEIQYPDDEEYISVSVEDEDCDDDSDNDDIDDDDSNDSLEYGIYYSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMS7</accession>
    <name>A0A0N5BMS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleoside-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMS7"/>
    <dbReference type="STRING" id="174720.A0A0N5BMS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000721200.1">
        <property type="protein sequence ID" value="SPAL_0000721200.1"/>
        <property type="gene ID" value="SPAL_0000721200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000721200.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13824" checksum="A7A9B45B48DBF00F" modified="2015-12-09" version="1">MCILNCGIFNLCALRDAIRIRKGMSLLSVVSHFVYAYNRSKDRSTGLSPAQILLNIPDRILHDEAIHNGLSGIYELIKDTKDQFTDPEQSRSWIKFNVGDLILRKFMHRKDASTSMKNQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNP6</accession>
    <name>A0A0N5BNP6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNP6"/>
    <dbReference type="STRING" id="174720.A0A0N5BNP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000752300.1">
        <property type="protein sequence ID" value="SPAL_0000752300.1"/>
        <property type="gene ID" value="SPAL_0000752300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF355">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894877" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="445"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="813"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000752300.1"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114612" checksum="4259DB9A97709A5F" modified="2015-12-09" version="1">MFCIFILIFNFALTTKSTTNVAFLRNDPNVSVACTVGIDHASSSGQCQNDISLKIGAACETSNNALGTVNACEYVYNENAKIIVGPGCFDEDSQITVLSKHWKVPFFSRSGNVWTNYNNTVYPNTIHVSFSNVIQYADSLKKFMDKFNLTSVCFVGPRERTNFHYQSLHVSVNNYFKTFFNNITTNAILIDESQLSSFSPSDSGLIGYIKLIVIDAGFDNLKNVLQEMEIPDLYRNGYVFIILCYQHSTVCGSNIGQFMSDYSIVLLSPYFENYTNIDLLMSQYFKDSYNRYRGVEYLGAYISCYASCMVTKLDKTLDGISVTNIMKGKQINSLLGNYAFDQMPSILVTQSFSQYIGANNSFIDLILTKPITTNCEKNKCFQLELVVNNDVFWHSQLESPLTHCYLTKSCINYLVIIICVVAAVAFLVIVSLIYMVRRQRHLNVYRMNWKIPKNQFKVIENKVSNSKNKQGNTTETLSSKRRYIHAYAIVETTKAEFLQLRQLKKIVWSKPEIKFITELKKMSHDNLTNFLGVNYNDSEKFYVLSTLTDRASLEDLVDDPEFTLDMTFKSAFIRDILKGLQYLHKSYVGYHGLLNIQTCLIDANWVLKLSNFGITNILHNLIRDEVLKNIELINLHFYQTISPENLQGCNFGINYPMGTPTGDIYSFGIILFRLTYRYGPFDGVNMVPKDILKGIVNNTIQPVYEETLEENSLLDLMKNCLKYNPLERPTLKVLESSIRTILHSTRSNLVDQMININEKYAQNLERVVAERTNLLIEAQQQTDRLLSEMLPPSIAETLKNGGTVEPKLYESATVCFVQIWEFAKFMEENSPPEVVQFLNDVFNMFDEVISSHDCYKVETIGDTYMVVSGVPKENEGKHVFVIAEVALSLRSHSLHFKVPVKPDWKLTIRIGFHCGPIAAGIIGLKAPRYCLFGDTVNFSSRMESNCPPNQIQVSEPTALKLMENPEYRLIKRGIVKVKGKGDVNTYWLNEHFHHGEPPPDPKPNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPN5</accession>
    <name>A0A0N5BPN5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromatin assembly factor 1 subunit A</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPN5"/>
    <dbReference type="STRING" id="174720.A0A0N5BPN5"/>
    <dbReference type="WBParaSite" id="SPAL_0000786000.1">
        <property type="protein sequence ID" value="SPAL_0000786000.1"/>
        <property type="gene ID" value="SPAL_0000786000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="337"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000786000.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="63149" checksum="B1F5493AF2722EDB" modified="2015-12-09" version="1">MYTFEIKVTPLPIGILFYIIKFLWMDKFVTKATLGKREPSILSDGEITDIIETPIKKLKLDTTIEESICNENCSTPEPLQSSPLKNINDESFYTDLTPGTTSVSDVKRKKLSKEEKEIRRQEREKMKKERELMAEKKKLEKERIAREREEERARKKKEEEEIRKKKEEERQVKEIERAKKRQEEEEAKKKREEERLAKKKEREEMEAKKEMERLAKKKEEEAKKLAKRQEEEAKQKKEKLQSQILLNFLNKATPQEKEKDDDKNNKENCYVEIAGFQPFYVKEGTIMAPINRREMLSGDKYDDFLKFTIKDDYPDYLKLIKKRSFKTYVEKIPTKAKYYMFADSYRPPYFGTFRKRSKTITGRRPFAMDEKLDYEVMSENEWEEEPEGDECRSDDETDEEIDSDDDDDEKEFFVEPGYLSEGEGQSEAEDGNSDDKVTKISNKKRAEFVKKEWEQTIQDKKKKTKSKKLIPVIFGPSYISSKELDYNNLPPGIFRSIIFDWSSLPDNEEVVKNENSEINKEQQLSIPKISTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPX3</accession>
    <name>A0A0N5BPX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPX3"/>
    <dbReference type="STRING" id="174720.A0A0N5BPX3"/>
    <dbReference type="WBParaSite" id="SPAL_0000794900.1">
        <property type="protein sequence ID" value="SPAL_0000794900.1"/>
        <property type="gene ID" value="SPAL_0000794900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="1">
        <location>
            <begin position="55"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000794900.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="56718" checksum="AE4EC70C7089F683" modified="2015-12-09" version="1">MTSFYETATSGMNFDRFVEDFTNDSAISKFQQHYWTAKQLIYTRLGKKEDEHVTAADMEFDVKLNLFNSIKETTKSLHYSMDTLHRSYVNLNDNVRYINYLLRSNIKYEKERLRMVFEKYTHSFDIISMLHKKLIGKTCKIYTDVKTFNERAVGDCSQTIEMADKSRIEYRGSLLWMKNISEELDPDANSQMNKFRTAQQVVKRCKSKLDKLKEDTEQKVELLDVSRNHLLSSLLIEYRDGFQTFYSNGITELNNLLEQLDGIDNYEIDILKILNDPVGKVLEEQEEAKKSNVNEEKDKKINDDEEIKTGDDNELINMNDEEECDDLIRIESPLGILNEEPEITVDDEWKSVPLTVGPLDELININDNIVEIPKLSPPPRYGEESKKHVSWIKRIKTKADDILESIPTTTSNLLGDFDSTPTSKYCPSLVMDKQETLCNLNTDREDSNINSKWDDILKQLDNFPNSMNLTSSTEREISDKKDDLINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPY6</accession>
    <name>A0A0N5BPY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BPY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000796200.1">
        <property type="protein sequence ID" value="SPAL_0000796200.1"/>
        <property type="gene ID" value="SPAL_0000796200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="971"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000796200.1"/>
        </source>
    </evidence>
    <sequence length="1456" mass="167020" checksum="DCE5F2D0327F9A7A" modified="2015-12-09" version="1">MFNQIVSLASYRGGVPYDVFFANELFLREIDTSDTKAITTFIYCQTEETRQEFYQIYPDLREVTWDNIQEFVCDQAKPTQLSMSEVLSMFHKETRKTDEPADAYAIRLKAMLREHLSAPTIDNVVMMKMHSQLPRDVLPDLVETTQVKLSDVVKVWDIFLRKLRVKASQSTGQNSYNHPSRSSHNDGSFRRSNPNGYGNMKFSQPVHQDTYQRSGWNSNLPNQQSIPNKRTNQSPARDSQLQREPGNQDHVYRAPKPCYTCGIIGHYSTNCPSKVVQQKSINLPDSFTKAPLIYECVSIADEPQIVLVDCGAQGNILGADKIHNFLSYGVTYCEDMMAQGIGEITQSIKASVTLPVYYIGTQKLYSALFYFIEGSETIINHETAYHLVIDILSSLDEMVSSKLLTCPHIYDETVIYPKLEAEITFISPPESKLSRPYNLNAKGKEILSKHLAKELRLGRIRYISNPIISSPCCIAMSDKPRVCNDSRYVNKFLTNVDVILPTIEEIQCAISDTQFFTKFDLSDAFKQIRVSENQQYISTISTFLGTFVSDRLQFGYRPASGIFHNLLSSVMSHIPNKIHFIDDIIIIGDFETQRNGVLSFIDVCAKYNLKLNLSKCMFFQDQVPFLGHVLTKGAIIPDITRTESLSKISKPITGDDMKAVLGRFSYVGKFIKQFANVTAPLHPTVEKIYHWSQVREKHWEMLLEAARNYMKLHYPPKDVELILQFIPTEFSFHVEIYFLEEKEKKLVNVVMRKMKNHEIPYSLIEKELAAISEAIVSANHLIQSRQVKIVSHSKMVETLTKQPLDLMKNNSTRLQRLLSPIILSNLPIQYISRPLQQVDVPKLIIKNLNIKNDRSVNTHQTVTLLRSYLKGELQKIIKLPHSIQELLPKLHLVQDLICFDFKPLVSKQIAEHGASWIHQLNHSGETLLYEELNSKIVFKGLSTIAKETVKNCLMCQKTRINVRKQPRSWSPALYPRHRGHFDIGYFEGHTIVLLVDAYSNYLHAAVIPNKKPDTIIAFFEPIICNQYPYRILVSDNEPVFRSKELIQFFETCSIYYEYPVEVMNSIPYTPTTNGLAEKYVGLLKRKLVKGISQNMSFKQSFKWSVDSLNNTINSRTKHTPARLYYVNNQEPVHDLFPSKLITVEEKHVFFKRRGESSKVFEEGTIIAQLGSRTYLIKDSEQNEIFVSKDFVHFGKECPTIKFKPLEGLENTFLMDEENPIFQASSPSPPAECVENETDERLQDEASEPLWKILECEAEGISLKNEDEFYDFVDKLPQDASYLMIDGSTYQGAGIGLYGVLGENDIVLSVRNYLRGKSTSPRLEVEALHSALRLITYFKIKECVIFSDNSYCVNAINKHWLWKWVETKTTSKKKNVPAYLSTWTKIAEMWSPKFLMVHVRGHKIAPHNIADRLARGESVELEISELPFQRVKRIYFPIEGTQEYDLRRIAISQSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR05</accession>
    <name>A0A0N5BR05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR05"/>
    <dbReference type="WBParaSite" id="SPAL_0000831100.1">
        <property type="protein sequence ID" value="SPAL_0000831100.1"/>
        <property type="gene ID" value="SPAL_0000831100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000831100.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20076" checksum="1C7AA47EC7B0BC0E" modified="2015-12-09" version="1">MIPSRKSTTASLSPINDEQPPKVSKPRGHIICSPKVLVNKTETKGSRKRSTSAVSHNPDVIDYPESSTSLHEPPKRSQMSTSTGRVNLSTSTSVNSSPSLLQQAPEFQQTSIDIFKDRIARNCPIFTEVIKNMITSSTFYEMYISSKPEDFKIWKPIGISDELWELLTMPEVRSLFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRE0</accession>
    <name>A0A0N5BRE0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C76 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRE0"/>
    <dbReference type="STRING" id="174720.A0A0N5BRE0"/>
    <dbReference type="WBParaSite" id="SPAL_0000844100.1">
        <property type="protein sequence ID" value="SPAL_0000844100.1"/>
        <property type="gene ID" value="SPAL_0000844100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000844100.1"/>
        </source>
    </evidence>
    <sequence length="986" mass="112461" checksum="7A76BF78DCC8C972" modified="2015-12-09" version="1">MDFVNNLLKKVSKIDIPKNSNCETANTEHHNLRRDFVRSKHVIILNGDVKSSYIFVTNEIVQSIIVKNNSEIIQLVKTKKNKKSCAGGMVIKNNYVPINSNSTTFCKILRADKCQAALGQNNQCVAMSSAALIMACIKSPLNWVRVDINTVLNQGNILYERSVNYLRSTNYSIDGRGYLSITNILRETILFNRKITFSTASCLSFTGRGKKARRNEINFGFVSLSEALNRLVNEHQFLILIANERASSIIHHDGVFFLFDPHSMDQNGRYCSNGVSCMLMFNTLVDLIKHLQANQVCNNAQFQLDGVNISVENLSDNNSDISTTRKNVKGRLSKIVKKEPLHLSKNKSNKKVNSKLNEEISLLKIRYDKCKKLNEKKKIQVQLNRLEKKSIATVEKNCTDTLKINEVVDNNSIKNSLVNNEEPMEVDICENNVSEKLIDFDVDIDTTLKEIIVVENKIKKCRKLNDKKKLQMHLNRLHKKMSIGTVKPESNDNFNLNKVLNCDLNKNVTINNKESMEVDICEKNISKDPIEFNVDIESTLRQVKNTKKKIKACKSKPEADKLRMQLVRSRKKLPESLKIIAKSDKLNDGNDEISVIKDVLVNFVQLDKTRKAIGKKKLTRRIKRLSSNIIKCVDVSLDKNSQVDSIVKALDSIQVANDSTKKKEKSKKSLKKQKLFPARNEEIIPNEHYLGPLSTGCEHCQAMSSTFMLHGEAKRVINTAVPENKDNLSYGQLYFYGPDVAEDIRNKNVNAFNEISVISNLTHIISKINMLALSHKHFGDYIREQEIKQKSENKAVPMYKLVLRPPANKNDRVRNLPEVTETAVIFQSEDEEVPDYNVLLCNKTGKLETLSHYSPLKDPATYPLFFPTGAFGWEEKKTYKKGNEQRSLTKLVYYQNLIAVRPSFNPLHHGGLLFQLFVVDAYTAIERDRLNYVIKLNKELKQKNNKQIEDLLEDYLIGDEDNEEAAKKVRELNFLAVTLVQEDLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS83</accession>
    <name>A0A0N5BS83_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS83"/>
    <dbReference type="WBParaSite" id="SPAL_0000872800.1">
        <property type="protein sequence ID" value="SPAL_0000872800.1"/>
        <property type="gene ID" value="SPAL_0000872800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000872800.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="43031" checksum="5A94C68E52930E44" modified="2015-12-09" version="1">MENRTEYFIDKVGYYIPFIYPYATSIEMVIHTTIIVISYPIYIYILYQIIKSWKVSEELKSIFYKATIIEGYIDITCHILEYIFILRKFYPPFVRWFLKIQPPVWFFMIVVNLKEYMLIVQLYYTAFISFVRWITLHYPVQGYLILEKYFWCFNAAGLMIGCFVLLQFEVNKQPYKLDTAIMPYSDNQEIGFIGFDVLISFNQPMFLIVSILSAIFTVPALMINIFTLIKIEKLKKSVTDVSDTKGVNKKSQKRMVMYVLIMSMNQFIFMGSRIVIFINPKIGGYDKSILMMFYGLRPYIMHFVCLTSPYALLILNKTIRQKVIKSLGFIPLLKKLKHRSTVKRTVSKAVSRTLFVNRKKNSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSB4</accession>
    <name>A0A0N5BSB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSB4"/>
    <dbReference type="WBParaSite" id="SPAL_0000875800.1">
        <property type="protein sequence ID" value="SPAL_0000875800.1"/>
        <property type="gene ID" value="SPAL_0000875800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000875800.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44090" checksum="8D01CB7EAEC63262" modified="2015-12-09" version="1">MFNKICFLCLGILISIILVSINSLHIGWSPLKALLDAGSGITCPSGNKAYIHPILGDLQPCSQSLNFYNKSSCPGKGIVCERFPILIPGFQDFCCWEDAITEEEELVIDEKTSSPDAEEELKETEEKTDLNEVLLPVILRPKTKKVKKISSSGKSSKGGTFKKTKKSKKTTTTLPPTTPSESEEEEVTTTTHVITTTIRQKPRRGLNCQNPEDSALIDFGNRLRDCYYQPCPRGYRCEISKELRRYICCGKEASLFLPPGMPPLPNPVPLIPRPFRPGGMNGGANGAPYFDDEEKKRAIGGGMNIMDNLRRSNIRQSPRKQKNSGKQDSNNGKNDGDLKQSNRNRLNEVTSQDDCSEDGHCGGDSSHLIDNSNPCTMDDCSPVIGTHELPCNNCYGPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSF3</accession>
    <name>A0A0N5BSF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BSF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000879600.1">
        <property type="protein sequence ID" value="SPAL_0000879600.1"/>
        <property type="gene ID" value="SPAL_0000879600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF9">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000879600.1"/>
        </source>
    </evidence>
    <sequence length="1234" mass="140062" checksum="42AD3F12273A41D6" modified="2015-12-09" version="1">MGGSGSTPIDNDHLIDELIFEASIKTKRNELAFRLVDRKRFFPQSGKNNAYLLQAWKASDEDAIRIHLSAPGVYAMALEALNVKKGLSFLNIGSGTGYFSTVVGFLLGANGINHGIECRENITEYAKEKGGQTLLSKETTLFDWCRPVFVTGNAFNIDENCVNRYDRIYVGAKVPEGKKLFFPKLLKINGICVMPFRNGLFKVTKKSEKCFEFKFIARVSFADLFPNNSEDSQPLILPEMKLPTLATAAVVAMRKRLREKVSEKVKVKMILKTLDKDENKPRRVRSLMREEIRREENERFDRLNRIRLHRAQRAAGGGGPGDQGGQNQNQQQQQQPNPPVQREPTAPNENVIINLDDNGIPIDDPFEIRDEDRRGDQFDFLEIFGDVDFNIRFRSPTPDPRPAQGGGGTTAPPVSNSNNTSNEENNSTSTNSSTPFSEYSDDDRTQSHSEIYDSEERMDDDSSSINKEEDAKEVKKSSSNAATTTKEDKKDPFLDLGTFSDFGDEDNDDDSHNHRPSRGGGTIRVEATMALDFEPDERRARAFRHIATLERQNIEERLRDRERFYENREREREANGLPSRRQGGGNQIVANILAPEPFLDRMRHMRQTINDLQRHALFHVDHMLRDNLLNRINRGTTSRSNSNNNNSSSNNNNTNTTQPRIPRPPQIIASRQGIDINEYIRRARDQRRLRRCLYSYDQRISLQRLGGWTGPNNHIDEGFFADAEDVSSSDQQTSSGNRGRNAMRPIRGYRRAIPSSRGGNMVGSIDRSEGSIHPSLIFEPGEGFEPARPNPVPYQSRFSPTSFPSSIMVDELDQEYGTQVVSIHDGPYQTQITVERRELNISSDEEVDTDNDNENNDNQSNNEDDNSSSINEPDAKKSKNNENCPCSCECHSGKEQQTSEDVKNEHNIQSDDTTDINDSKSDDVKSNLRKRKREKGEQILVKETEMKEAKQGKDSPPIKKSSESNSSSTIERVVVISPNEENPVCRPLLPQDGNEEKQEDDSVPSTSTKISAMKHEQSCDKQDPSTNESFNERVELARRRIRARVAAGTQTSPSREGDDNVRRGVDAQTNTEYSPNRVSYEPGYLDFERNFFTSRGWDPIPLTDPIRDTVVRGPNHTLSLVPRYIPPPESNRHRGSGHGSRSYLRRSIHAVDEEMNRRLQQMQRTLRGPFATARRVANLGDLDDDSRELSNEESERVNQTREQREDITDFCTKYKALIEEMNLSSTMFNELLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU69</accession>
    <name>A0A0N5BU69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase from mobile element jockey-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU69"/>
    <dbReference type="STRING" id="174720.A0A0N5BU69"/>
    <dbReference type="WBParaSite" id="SPAL_0000938900.1">
        <property type="protein sequence ID" value="SPAL_0000938900.1"/>
        <property type="gene ID" value="SPAL_0000938900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938900.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27723" checksum="15BF029BE8435110" modified="2015-12-09" version="1">MCFDNNLIDDESSVKLKIDGKEIEKVSQFKYLGKIISINEKIYKNTLPKDDNSWNSFLSERIRGGWISFHKHKRLLLDHSIALEKRINLYVQLVRPSILYSCQCWNLLKTQYLRLQSNENKMIRLISRKSILDHINIKELYNSIGLTPIVNVVFRLKLRFIGHTVRQKLNKPAKMSLQHFPYGFKRRKGRPPLRYTDCLKSRSLWLRDCLDRNLWKSTNSQINLLDRLYLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUU4</accession>
    <name>A0A0N5BUU4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUU4"/>
    <dbReference type="WBParaSite" id="SPAL_0000961200.1">
        <property type="protein sequence ID" value="SPAL_0000961200.1"/>
        <property type="gene ID" value="SPAL_0000961200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000961200.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22228" checksum="F3189C11FCCDE8F1" modified="2015-12-09" version="1">MEIWFGLDRFTQEMDDYNVATVNYREQETIHRSFFEMKTGETCARISRKLAFPTSVVGDTFEVAYTKEFFMNYTNGKWIKESENKCPNKGNLHLLNEISSFGIDGNSTMRDMSFDIKEVPRYNSKLSSVQSDKESQKIVYNANTSTNIPDTTKSFKDSPIPICHSTPRISNILPTNTIHEKLNLDNRTPVTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV98</accession>
    <name>A0A0N5BV98_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV98"/>
    <dbReference type="STRING" id="174720.A0A0N5BV98"/>
    <dbReference type="WBParaSite" id="SPAL_0000976300.1">
        <property type="protein sequence ID" value="SPAL_0000976300.1"/>
        <property type="gene ID" value="SPAL_0000976300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="284"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000976300.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67778" checksum="5E605EF04673EA50" modified="2015-12-09" version="1">MTSNEKPTLVELNPDSTLIDREFESYRLAFSNNKISYTTLPNSVLNCERSLKLYSFLHLRLYADQNNIFLDSFAPCIKVYTVLRDGSIYSLEYDEDSSKFINCTRVFEHFLKEDNEGWEIPKDDNEDYYNKYSELDNYPYSLYVVSNEYVVASNGKTDVFVFKKGESKWDSIYREELPKNAIVVDARMDGNDKVHILTKTIIEKNECPYNVEGISTFLCSLRWIKLKIENESFTKSDEKIIYAPGNVEFCTFDSDFESVIIQSTMEPFIEYVKVENDELMDCLDGRKAYSWEQNESKIFLEIALTSPLSNDDISVNLTNNTLNILAKGTDIFSETLVEEVVQSSIVYNSNGGVLKVEFDKVKKGEWSKLVAESNLQKESSVPIEGLDEKFDSFNIENNAIFTKREECDDERLENTFIYWVDFKSEKITYQSSLITDMPLFSQKFSPTSPTSICLSEDVDGVIWSFPPKKSNKKIFHKSTFNALGYIQASKSKRKYTIASPQCSYVSIIETFKNIHVYWCSEQLSTEGLVNRKSGQRISKIAKQNVICLTKESYDDYDSKIVVTDDIFGCICLEKFIIVALKDELAVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVD9</accession>
    <name>A0A0N5BVD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transferred entry: 7.6.2.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BVD9"/>
    <dbReference type="WBParaSite" id="SPAL_0000980200.1">
        <property type="protein sequence ID" value="SPAL_0000980200.1"/>
        <property type="gene ID" value="SPAL_0000980200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001370">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="880"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="89"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="412"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="800"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000980200.1"/>
        </source>
    </evidence>
    <sequence length="1406" mass="155490" checksum="9DBB3426AC298C40" modified="2015-12-09" version="1">MTIKNDNKKNNQNGKKKKDPATALDMDSVPVNEDEEDKGFLYEPSLLSKILNYFLCNPSANVPRMVSAKPVTLFGLFRYANKIDIILLAIGFVTTIFSGLAQPVMAIISGRITNNLLTYPSTSWEFRIKAYENVYIFLGIGVFTLFNNFIQFMTFSTVCNRIVARIRKEYLRSILRQNAGWFDKTQAGVLTTRLNDNVDRIREGLGDKLGLLLRGAWMYVSAVVIAFSYEWRTTLMMLGVAPATCVCMALMSQLIGFSTMNELMNVGQAGAIAEETILAVRTVQSFNGQEERIEKYRNALLGAIKHSILSGLWSGLFGGLFFFILITYLGCGMCYGGYLLSVGIFGSPGDVFIVVMSMLLGAYFLGLVSPHLTVLLNARVSASTLYNTIDRVPPIDCYSKKGKVIENVIGKVQFKNVHFRYPTRKDQKILHGIDFEVNPGETVALVGHSGCGKSTSVGLITRLYEPEEGSVTIDNVEVRDLNIDWLRNIVGIVQQEPILFSDTLAENLRMGNPNITHEQMIEVCKMANAHEFIENLPDKYETLIGEGGVQLSGGQKQRIAIARTLARDPKILLLDEATSALDTQSESIVQSALNNAAKGRSTIVIAHRLSTIKTADKIIVFEKGNIIEQGTHSELVKLNGKYAQLVKAQQFTNLDGEEDNTRGGSEDGESRVYRAEPVDYRGNNSVRSSISSIQSSIRSGRDAFMRADANNQSFRVQSALLSDMVAMDPQYALNAINELEELDESQKESSANILTVYKEADGYYGLLLLGLGIAILRGFELPGLGLLFTHVFRLFQAITIAYFAACGAGTFITQLLSSVIYAYTSGHLTLKYRVLAFSNILYQDASFFDKKINSPGELITRLAADVPNIRALLDGRMLQILYGITSIVTCIILSYIYTWQVSTLGVGLLIILGVSQITLSLLIQNKTKELMKNDEAGKISIEAIENVKTVQLLTRCDFFIHIYNKAVTLKKKNEFQRSKLEAINYAISQTFQYFILTVVYAIGIHVIYMGHKPPQDVFQGVIFMLLGSVAVMNAASYFPEVVKANTSAKTLFKIIRSKPLTGDHMAGEKHQIRGNIMFDNIKFTYPARKNQIVMNGLHFSIQKGQTVALVGPSGSGGAVRLDGNAASYFPEVVKANTSAKTLFKIIRSKPLTGDHMAGEKHQIRGNIMFDNIKFTYPARKNQIVMNGLHFSIQKGQTVALVGPSGSGKSTTISMLERFYDPSGGAVRLDGKDLKSLSLYYLRTQMALVGQEPRLFSGTIKENICFGLKNVSQDKIDEALELSNSKNFISLLPEGINTEVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDKARLNRTCVTIAHRLSSIQNSDLIVYIAEGQVKESGTHNQLLAKKGNYWNLIQQQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVH5</accession>
    <name>A0A0N5BVH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVH5"/>
    <dbReference type="STRING" id="174720.A0A0N5BVH5"/>
    <dbReference type="WBParaSite" id="SPAL_0000983300.1">
        <property type="protein sequence ID" value="SPAL_0000983300.1"/>
        <property type="gene ID" value="SPAL_0000983300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000983300.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42844" checksum="0B0188440BDB110A" modified="2015-12-09" version="1">MNTSSIIIDQISFSLNFLKEINKQSGDSFICSPISLILPLVILLFGSEGNTRNEIKNVISPDLSISQIYNYYSVINEKLKYEDSFITLKTFNKGYITSEYEIDAKYKDFIDTFFNGSIEQMPFSNISHSIEKINDMVSNSTNGNIQKIIEANEISYGMKFILISALYFKSDWHVKFVNTDTKITQFYVSQNESKEVLLMSLENKFNYFENDLFQMISLPYLGKNMKMIIILPRIRYTHDNFIEFVLSTNNFTTALNSMKKEFVKVMIPRFEIQSTIDGTSILKNLGVVDAFDESKANFNGISSNASLYINDVKQKTKIEVTESGTEAAAITSVRLSLYSGGDVNNGEVITFRADHAFSFYIIDDKFNIYFSGIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVN8</accession>
    <name>A0A0N5BVN8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVN8"/>
    <dbReference type="STRING" id="174720.A0A0N5BVN8"/>
    <dbReference type="WBParaSite" id="SPAL_0000989400.1">
        <property type="protein sequence ID" value="SPAL_0000989400.1"/>
        <property type="gene ID" value="SPAL_0000989400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="74"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="336"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="80"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000989400.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54140" checksum="32C16C323B3E8EA1" modified="2015-12-09" version="1">MAEIFELDLSDNRGIPIDDAVEMEEDFEYIDVADGQIEAPPPSSSYMEDPNCVGFELDAASVNPPNTKVGPEDFELLKVLGKGGYGKVFQVKKTSGADKGKIFAMKVLKKATIVKNQKDTAHTKAERNILEAIKSSFICELLYAFQTGGKLYLILEYLSGGELFMHLEREGIFMEDTASFYLSEIVIALEHLHKQGIIYRDLKPENILLDSKGHVKLTDFGLCKEAIEGDQVTHTFCGTIEYMAPEILMRCGHNKAVDWWSLGALTFDMLTGGPPFTGENRKKTIDKILKGRLALPPYLSVEARDLIKRLLKRNMGSRLGSSPEDAEEIKAHSFFRHLDWQMVKNRQLEPPFRPTIVNEEDASLFDTKFTQMTPVDSPCDTTISMSVNPFEGFTYVAPSVLQSNAPTKTTRSRRHVTTQHDGSKLVQTLPTIASSSNLASNSGHMPVLGEESMEIGNTPRQSESQVPLHNGIHSFGFGGYNSHMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW11</accession>
    <name>A0A0N5BW11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PAP2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW11"/>
    <dbReference type="STRING" id="174720.A0A0N5BW11"/>
    <dbReference type="WBParaSite" id="SPAL_0001001700.1">
        <property type="protein sequence ID" value="SPAL_0001001700.1"/>
        <property type="gene ID" value="SPAL_0001001700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF34">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001001700.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45139" checksum="EDB678FACC4CEE72" modified="2015-12-09" version="1">MVFSNLLKGINIVILFIKGIKMRRLILGSIRKCILPIWESFDIGFDPRKNGYEKAELSPSLNETFFNLDVELNLGLRGKSMNKNGNGEKVSLQPKKILFVVILQVLAGFLNWIALAYIHDHSGRIALPDIVFSFIPEIKWALKIGDFMVTICSGSIIFLFIFHKHRIILIQRILFIVSSLYIMRALSLICTQLPSGYYDNYSSCQSQISPENRTLKTFFQRVMGQASAIGFQDNDSKMLCGDMLFSGHSLVMMTAVLSVSYYSPTKYKFLKYIIGICAIIGMISMIISRVHYTIDVLFAYWLTIGLFTLYHSFCEIETYRERKNSIIGRLWISKIIGWLEENIPAGKITNEFEIPFIKKYNKTGHSKSSIDVDKYNDIHADDSTSKTSPSSVTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW44</accession>
    <name>A0A0N5BW44_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cnd1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BW44"/>
    <dbReference type="WBParaSite" id="SPAL_0001004800.1">
        <property type="protein sequence ID" value="SPAL_0001004800.1"/>
        <property type="gene ID" value="SPAL_0001004800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="7">
        <location>
            <begin position="1099"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001004800.1"/>
        </source>
    </evidence>
    <sequence length="1371" mass="159454" checksum="041488AB4A79A81B" modified="2015-12-09" version="1">MDNFNFLMGINDLHERNDDDFYKVHEILSDKACENVFDNVDICVDSETYSLQDLCMIFDACYSTIRSTNIFLRIKALDRILEFGHKQFNVIDDYLNDLQHSTDYPVLEQQQKFISNDLLMIIYAANNIMSRLEDSHKEMYSLVSVNKIGGSEKKATGDGLIPEINELRSRFIEYVTNIFKNMSEKPRFLSIVEGSGYLNEVCETTVSILIKCMDHKRFGYKDEKDDLVRIFRSFAFINKCLKSPETIGFELSKMFEDSQVFCSFTNFHFIDAMCDAEESFSDAANCFEDIYVKLIECFSEKAPTDLLKEGCSKVFISSLKSLTERRPKLMLKNISKLALVLFADCNYMYKNCILSILGQLVIKWDEIGDHENIKTRRFFVEKILSFVEDKSSLIRSKCISILKSIIEKRTLLNDSLSDIGVIRVLNKSLMDEQTSVRKVALQALREVLQKNSYSETLSYNFAYEKYLKALTKFETVTSTSFSFNENDILKDVTTLYSTYNETKNLSKYSPVPLDYLPPLLDDEERINYCASYIRERNIDLTIPLDINKVSNDIYNSVKEYLENDGTDLETNLMTRQCFSEIVHFYNKLSFIRQMEDSLDKILSIAFTGSVYEVKEALSLLCIFKQFGIDNSISSFRKICRLAFRKDEDLQHEVFNCLISVCISEHGDIDTRYRSTLQNVMELLIGDEELQPGVEEAITKLIICIDTTNYFKQKEFMNKKMFELLYNKYINSEEYDSTNRLAAMRLIKILSRSKPTMVKERLDDLKNLFMSEANPSQFHVEILEIIYRCGKNNHDLTDNKCLLLHFNDDLIKFLFSELQKNFDSQNYALWISIMQKFVAIVFDVCYETTFIISEFFQVCLKKLEFHLKDQACLEQLHDDIVELLGKGDDLTMAAALKHKIESTKKFICYRNKKVDLVAIRLLEFIAEVGLRFTVYNDKTFVQTCSSILDTLKKLKNNVKKSARKFEDFNGEIGNLTILEQQILNNEGIFHISENVEVQDEAFDQGLPSDEYFKSIAINNANNEAFLEGRILERMMHIAIFICLSEKFKKDEDDSTNCFSKESVNSAFMALARLALINDTICSRIMVILFDRLSKTESHTKINLLITITDLLIRFPNNVDPFSGHIIKTVLDEDIRVRYTSLSIVIFLILKNLLNFQKSITDVARRLLDKDDVISSIAQYFFQELMKEDKEIMKIIPELVSELIFRRHEISFNEYQSIVYFVLSLVEKDSISDYLINNFCDRLKSNTSGDEVQRVETAKRLIYSISLLDITEKSFKYISMALPNFSSFILIEQEICEFFKIIVDDVEKLHAKTNLEDIKDMCSKFLYFANRLIDGDSDNVAENEEQQQEYYKEIVERNKKPSRRRRALPLNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWP7</accession>
    <name>A0A0N5BWP7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWP7"/>
    <dbReference type="STRING" id="174720.A0A0N5BWP7"/>
    <dbReference type="WBParaSite" id="SPAL_0001023700.2">
        <property type="protein sequence ID" value="SPAL_0001023700.2"/>
        <property type="gene ID" value="SPAL_0001023700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000014">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001023700.2"/>
        </source>
    </evidence>
    <sequence length="663" mass="75646" checksum="8F2EFABA588AB998" modified="2015-12-09" version="1">MEGPLSKWTNLVHGWQYRWFVLQNDILVYYTSREKMLRRQQRGCIRLRGATIGIDGVNNSLFTVSVDNKIFHLQGRDQNERDKWVRALEKTIHNLCGYYKPAEQDPLTLLNEKLLEADNQLKIAMEEVHILESIEETSTNERKEKIREILKSGNILLDTIRSSVIFLQMVKSQIDSNGKHKARSGSLAPSNNGTDDDKSVSPVAAIKHEEKEIVDIVPPMSYSSSEDEDEFFDARSLNGEKNYSSFNSEKRISVSSIPIDESAMRVYNQTDVEPDWGDSNEDFDKIYENNEESDLGNVQQQHGSVLMHLLSQVSVGMDLTKVTLPTFILERRSLLEMYADFFAHPDDFVGGTDLETPESRFIAVVRYYLSAFYPARKSGVAKKPYNPILGETFRCRWTVPGMELSGEKTTSGPFPGSDKNQLTFIAEQVSHHPPISAFYAEHPGKKISFNGFIWTKSSFLGLSIGVANIGFGTVTLHDYDEVYKLTFPSGYGRSIMGTPWIELGGRIEVSCEKTGYTAEIDFLTKSFFGGKPHRLTGSLFRPGVKKPILTLRGEWNGIIYGKPLNGEEYVFVDVKAKPEIKKECDPISKMGDRESRRLWRHVTTALFRNKINLATNSKLWIEQRQRDEAKKRKENGETWNNIFFKKQDDNWVYDNSLGKRTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXT2</accession>
    <name>A0A0N5BXT2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmodium vivax Vir protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXT2"/>
    <dbReference type="WBParaSite" id="SPAL_0001060025.1">
        <property type="protein sequence ID" value="SPAL_0001060025.1"/>
        <property type="gene ID" value="SPAL_0001060025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895149" evidence="1">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001060025.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22828" checksum="12AD7ED341DD7ED8" modified="2015-12-09" version="1">MNYRFLFIFFHLLILLNIIYHNSVVCEEKLLQVNTFSDLLKGGLNGGKKIKNNDKTVPEVVEESEKLEEEEKIEEKNPLIISDNNFPPKYNVFCVPNSVSLKDRFCYGNLDAYIIGCAHNNYPLHLASFCFGFKHLCSKVNFPNDGFCDKEYEHYSKFCKIDDRDSCSLDTKVYCDYANGNGTRDDEVSRLAYGCFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXW7</accession>
    <name>A0A0N5BXW7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BXW7"/>
    <dbReference type="WBParaSite" id="SPAL_0001062900.1">
        <property type="protein sequence ID" value="SPAL_0001062900.1"/>
        <property type="gene ID" value="SPAL_0001062900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001062900.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="76226" checksum="4128E3A5891B570D" modified="2015-12-09" version="1">XTNNVEEEMAVETAKTTDSLVLDECISIVHVQEEVSSSEDQMVVLDKSGNSPVSDHMDVETHSSSTPSRISNNDLPVKSNLDRSTYSNSQNVSRICDVSHDSTNSSRNVGDDVNCVNRSTVFDDSNSCMASNVTTCTLLPEYSSSSLQINDSVSNSTSEVGDATVSGDVLAVMNDLKHNVSTLSDSCSKKTDGTYLDLLDKKIDGTFTRYNEEINSLQEQLREQKEINSNNYSHFTKIKSELDQALEKLASNDKEFAKTKSEYETEISMLKGSVDELKKVLSEKNKEVSNKRIDVLKKERDSLEKELKNKTANSSDLQKQLTAANDTLQKYRDEIVNHENSIKNINASFGNCQKELSEIKISIANKDEVIAKLEKTVADLTKEKEEFELTVERLTVENDKITEENEKLNDVNNRLSKDLSSIESQVRDAEQKAGESKMEQGDTSNEFGKIVTGSINDSIGSSTSSFNDSVRGTMTVVIEGLKDDYGKLLDKVNKIALDKTPQKENITKITAEIMSSLKEIQKELSQERMKMNNILSEMNKQHTVYPDGSHNSWKNEELFNLNEIIPSIRQAIHKLSEVNNSKLSEGEFKQKLDLLSRENADISKNCEDLRMKCINLESSVDNITEKERKMAKELLSLRIKNMEYEIKLGLLTPEAAAEKCCDPEYSIEYFQKVLNNVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY72</accession>
    <name>A0A0N5BY72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C76 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY72"/>
    <dbReference type="WBParaSite" id="SPAL_0001073300.1">
        <property type="protein sequence ID" value="SPAL_0001073300.1"/>
        <property type="gene ID" value="SPAL_0001073300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001073300.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33098" checksum="D2F80AE154B37129" modified="2015-12-09" version="1">MEFVNNLLKKVNKIDIPKTSICDFTDSVNHNFVHDFINSKHVIILDEDIIVSYILNTNGIIYSITIRNNSQADDLVKAIKNKKSCAGGMVIQNDYVPINSNSANFCKILGANMCQAALGHNNQCVAMSSAALIMACIKPPLNWGKFDINNVLNQGNILYERSVNYLRSTNYSIDGRGYLSITNIVRETILFNRKVTFNTASCYSFAGRGKKVKRNEISFGFVSLSQALNRLVNEHQFLILIANERASSIMHHDGAFFLFDPHSMDQNGRYCSNGVSCILMFNTLVDLIKYLQANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYD1</accession>
    <name>A0A0N5BYD1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYD1"/>
    <dbReference type="STRING" id="174720.A0A0N5BYD1"/>
    <dbReference type="WBParaSite" id="SPAL_0001079200.1">
        <property type="protein sequence ID" value="SPAL_0001079200.1"/>
        <property type="gene ID" value="SPAL_0001079200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895047" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="559"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="924"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001079200.1"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122272" checksum="451D9310B146DD85" modified="2015-12-09" version="1">MLLRILLLIALLNLINGQQTNSTLSPSLLNTTEIMENFDMPSYSKRAPFPFNGPITVNIGFFIPKGDIEYEESIGYYKTASAITIGLQELIHAGFIDTTKVNFKFYFRFSNCSVVQGTKTTIELLQNDNVDVFFGVSCKELSDFMSVIGAAYETPVYLWGPTISTYIASSNQFRSVISTSISAEDYSNCVRCLVEHFNWTKIAIIYMNTNYSSVCTEMQTNLVNTVLTTSNIVVVYSGQINSSKNSMNESLLAISKVARIVVVCIPSNEVIRKLMLTAYDLGMTNEEYVYLHVDVNDTVLENSDQAIPIWNDSIGVSDNRDNDAFKAFKYSLFIDKMIENNVNMTKFARNISLGMLDYPFYCNESECLENAVDPNFHYSTYAPYLADTVILFGLALNRTLSTTPLLYTNADTLKNNSAYFFNGFSGAVFLDNNTVRSGYFYVKYIGNDSKRQISMIITKNENQTYFTSEYSNTSESEMWWNRKGSARPSDTPLCGFLGDKCPKTFWEEYLVTIIIASVIFITILIFSIIVIIFLRRSRIRQQRQLDMLWLINYEDIKNIKTNERIYGKSIASISESQKSLNRDIEVTDNENIKNRLSLVEGEDRRHVAYRYNDETVVGERFRGPAVITAAEKNHLRTLRNIDHECLNKFLGLTESPTHVIAIWKFCIRGNLKDLLRSKMGEIDPYFVVALMNDIAFGIKYIHTSKINCHGRLTSACCLLDSNYQIKLSNFGLPFIRKNVRRTYEEQLYTSPEILRSQNLLGTKEGDIYSFAIISSELLNKSLEWPGDNLGSTKNDIIMRIKNSQNGAFRPIINCQVTERWIGKVIMIIKDCWNEDPLKRNKIEDVRKLIKNSMNNKKISMMDYMFNKMENYASHLESEVMGRTKELMEEKKKSDILLYRMIPKSVADELKSGRTVAPEYFQSATVFFSDVVGFTNLCAQCTPLQVVSFLNQLYSRFDELIERFDAYKVETIGDAYLVVSGIPIRNGNRHGEMIANMALGFMESLPSFKLSFLPDYRLNLRVGLHTGSVVAGVVGLQMPRYCLFGDTVNTASRMESNGMPGCIHMSSDMYGLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZV8</accession>
    <name>A0A0N5BZV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZV8"/>
    <dbReference type="WBParaSite" id="SPAL_0001129600.1">
        <property type="protein sequence ID" value="SPAL_0001129600.1"/>
        <property type="gene ID" value="SPAL_0001129600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001129600.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59861" checksum="29B3640F9947E854" modified="2015-12-09" version="1">MGIFFYKVALSEQDFEYKDSSKYDGIFYVGYKEINDDKYISLMYLTKSTEQYLLNIVVCPHETWISNHSLSEYIVDKSNTIPFLKRSRNDGRYYYYKINCCGETSKIFLKCGHINQKFMPSIDVGYSWGLTVKENLLHSKSSFTFNFEYQDLTINSENNLAYNELGSLLHPSLVVYYVMPPSDNGFGFYSTVIGRYKNDSKLYFGQGIFVLFLNEYKTLDKEVRDMAAKLRTDNHIVTGYSFNIRPQFLVPNIETTLRLTVNGVVQKFKTAKNSESMDTYTVDVRGMENGQVGCHAVPDNITHPGFKDFYEKSYPTYLYIFDENKDEPIPVNDTKSLVSNSTYVCFPDLKDRDDENFLKLAKKYIKIKKFKIHLIESYDSVRSTGLDKSTHSDKLTHSNESVDSSKSNDSTKSKSTIWIITGVSVGVLLIITLILLAGLIFYRKRLVKKKGIKNSLSSGKSSSASKSSNTIKSEYYVAGIQNKAGNGGPKNIMNKKIVSNENLKISSQNVKRSKEVRSYEVQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0P9</accession>
    <name>A0A0N5C0P9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0P9"/>
    <dbReference type="WBParaSite" id="SPAL_0001157700.1">
        <property type="protein sequence ID" value="SPAL_0001157700.1"/>
        <property type="gene ID" value="SPAL_0001157700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001157700.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="38437" checksum="ACD886145626FB03" modified="2015-12-09" version="1">MKFLDYFVYIFFVYIVYCIHDKVNEKSDIMKFKRLCKSISITKNNEFCIPPYIDYEFKYRIVKKYNLTFCQMDKNLSSTIRMVLGSLILNNGTYSNVTISDESWFKYYYYMKNLRRKKLKNVVAEFFNTNKTELFLKNNKLLAIVRDPIERFISSFTSKCVVEKPWKIHPGNCLKCSDNVTCVINNLYKKLKEISLDQSKLKYHDYYTQHFVPQTWNCEFSKYQKYYKILFYEDSSEGLKKFYESLLKILKKIGVSEKILMILKKSITTKRSFNATHDKEVRKNIKNIIYSNPILLRKLVKMYLNDYVKLNISFPEKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0S3</accession>
    <name>A0A0N5C0S3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3 10">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3 10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0S3"/>
    <dbReference type="STRING" id="174720.A0A0N5C0S3"/>
    <dbReference type="WBParaSite" id="SPAL_0001160100.1">
        <property type="protein sequence ID" value="SPAL_0001160100.1"/>
        <property type="gene ID" value="SPAL_0001160100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001160100.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79243" checksum="34A66DE7358D77BC" modified="2015-12-09" version="1">MSTKHVHVSVCTLNNWSLDFDGNVKRIIQSCREAYERGAKIRVGPELEITGYSCLDHFNEIDTETFAWESLKKIVDASINMRSLLIITSMPIRYKLTLYNCAIAINNGKIIFIRAKQSLCDDGVYREGRYFNSWKMAGEYVTFEIPPEYTFTQTSVPFGDGILKSEDGVTVGFEICEELWTCQSPHKMLTLENVDIICNPSASHHVLSKSSHRLNQLLLGTTAKLGGVYLYSNFRGCDGERVFFDGMSSIAQNGKLFCQIDQFSIEDVEVADAIIDLDDSRNYRKNIASNRNASSFSITNPYINFPLNLLGADEKELSEPIEPKILSEVEELSLGPPTYLWHYLRRSKQAGYFVPLSGGMDSASVATMVRLMCEQVVNCRKRYIEKYGPDKSDPSHYYMGEIVNCTGKELCEKILFTCYMGSKNSSNFTRESALSLANDLGSRHSSVLIDTIVDSCLSVFNTIYNFIPSFKSTDNREIMALQNIQARIRMVLAYLFAQLSLVGEKRPGNLLVLASANVDESLIGYLTKYDCSSADFNPIGSLCKSHLRSFLNYVISTYNFNSLTRITNSPPSAELRPLVDGEVAQTDEEEIGLTYDELSTIGKLRQPRNMGPYSMFLKLSHLWGKKMSQEEVANKVKLFYRRYAINRHKCTVLTPSYHVTTYSNDDHRNDHRPFLYPDFKMQFDKIDAAVKERKERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1L8</accession>
    <name>A0A0N5C1L8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1L8"/>
    <dbReference type="WBParaSite" id="SPAL_0001189200.1">
        <property type="protein sequence ID" value="SPAL_0001189200.1"/>
        <property type="gene ID" value="SPAL_0001189200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001189200.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8717" checksum="3DCDFBBBC04118F1" modified="2015-12-09" version="1">MIRLLIIFHIIIFFTFSLPIKFITNDSIPLLEIGKTISGSPIIAIEHGESNPIKEDSIIGKDSENDPISKLLNGPKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1S4</accession>
    <name>A0A0N5C1S4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1S4"/>
    <dbReference type="WBParaSite" id="SPAL_0001194400.1">
        <property type="protein sequence ID" value="SPAL_0001194400.1"/>
        <property type="gene ID" value="SPAL_0001194400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001194400.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16039" checksum="93B2E688A735F688" modified="2015-12-09" version="1">MQPAEIPEDDWVTLTMLGDYMKVTNKSNCKKIDFIPMIWRNDTMFTVRDDPITFPAATANYDSCPCNEWEYGFVVDGIIFYSFYETKVKIKEEKLHFWHPEVSRYLTGDETSDGPGAEYIGWPVLVQEIGNSVENKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C214</accession>
    <name>A0A0N5C214_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH_Tnp_Tc3_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C214"/>
    <dbReference type="WBParaSite" id="SPAL_0001202966.1">
        <property type="protein sequence ID" value="SPAL_0001202966.1"/>
        <property type="gene ID" value="SPAL_0001202966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001202966.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17212" checksum="EAFBED6A717B206E" modified="2015-12-09" version="1">MGFTMEERLFMALDKPSPAISLVTRNFQKLMKTGSVNDREHHPKRTVTHKKNSLVISRMIEENNGKISTRQLASDTNMSRSSVMKVLKDRKLFPYKKRYVNEMRPEDSVERLTFYLKTKGMVEEGLFIGPLLVFSDEAYFHLTGHINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C231</accession>
    <name>A0A0N5C231_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C231"/>
    <dbReference type="WBParaSite" id="SPAL_0001204500.1">
        <property type="protein sequence ID" value="SPAL_0001204500.1"/>
        <property type="gene ID" value="SPAL_0001204500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001204500.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43441" checksum="F3860813E4620A1D" modified="2015-12-09" version="1">MNFEESLKLITQLRQNHQKEDALDYFKNINISLLPLHNTKLLLIYGHYLSNYAISMSLNSTSYLKKKSLWKSIIKLLNDMFDTLDNIENYEEKFNVLLMICNICSFYKEFDDDLLVESCYEYGYMLKNNIENPKNINSYSKERRNELLDYFENIEYTFVMRNYKKGNEDDINIKENNSNNPQLTRSKTLSFGGLKEDSPLWINGSIDQAIVQKKIHNKKLFRKNTLINIDMFNDPSAPAVQLIKKRVQEVEKDIDNYEKIPDKDVDLNDTYQLDKFSPISNEDKDINESTNDITFNENDSLFGEDNNNDNSKKSFSLQDFRQKALDDSSGNCSPIESINSSHITLSESFIEELSRNAPSSRRRSKITVSPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C247</accession>
    <name>A0A0N5C247_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C247"/>
    <dbReference type="WBParaSite" id="SPAL_0001206000.1">
        <property type="protein sequence ID" value="SPAL_0001206000.1"/>
        <property type="gene ID" value="SPAL_0001206000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001206000.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="41045" checksum="9A61AA719308841A" modified="2015-12-09" version="1">MVPAQDSEGNNDHLLLDYLDGNFRHQTPCVSGDVKVHRFNYDIYIDVMRDNYWTNNIKIHEAFEKSFLEFVVGDDYKHLSEEALLTATQAFLLAKSLNGKHNLKEYYSVKQESMGFFGKIKSFFNSKESKKYVSYQKLEDYFKEMTNFEITNDGEIIRQGSEIIKKKIQEFAKVNYKESCRRKNEKQRIFSENGTPNQIIRKYLDRKDIIAEEIEYKEVYLVHVCKQEKPKEIHSDFKLDEICYEKMPVVLNDESLMFADRKNYLSHFSSKRSCSSLFSIKNLKSPYHKAEMDLYDSTTNAFMERVSYVFARLSTGWFGHTLQKYKFYICIGAVFLFVFGTTIALAVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2D6</accession>
    <name>A0A0N5C2D6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2D6"/>
    <dbReference type="WBParaSite" id="SPAL_0001214600.1">
        <property type="protein sequence ID" value="SPAL_0001214600.1"/>
        <property type="gene ID" value="SPAL_0001214600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001214600.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8070" checksum="EA819CC30E6DA485" modified="2015-12-09" version="1">MQSFLKIVSGDFSSNGRSFTYDYNKWESTRSFTSTKITDELDFLLDSSNWTIPIVMDINFFIVYSVYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3U8</accession>
    <name>A0A0N5C3U8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Disintegrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3U8"/>
    <dbReference type="STRING" id="174720.A0A0N5C3U8"/>
    <dbReference type="WBParaSite" id="SPAL_0001263400.1">
        <property type="protein sequence ID" value="SPAL_0001263400.1"/>
        <property type="gene ID" value="SPAL_0001263400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895524" evidence="4">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="227"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001263400.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53614" checksum="22A3D8E2C728ACA8" modified="2015-12-09" version="1">MSLLLYVFLLIILFISTNFCITNVYDNLDNSLEKKYLEVGMYKDYDLDIRDYQIDLVIEKTNEFLEKAILREENSTKSVIIQLSYDEIKTIKFFSKIQIISQISGGYKGGNILFTNKNFAKNSHEVVGFSFGLFCNSLPFNIIGILVDVTESTVSFENVLARRILHEIGHSLTAIHDDNEDYSYNIMAPLEIIVEHENNTLFSNPSLKAMSRYVFKSCKNYLVDINVKNCGNGILDKGEECDEGHKNFNVNFKCCNKFCKLKQSAKCCDNNHDCCFQCKIAPSNISCYPKVLYQCIDESFCDGINPICPKPKNLPDNTKCLKNGGRCFNGKCVDKCKYVDENYVHCLCEEDNFRCYQCCKETNDGVCKPLSKKIPLEEGSVCSMVNKNFRCNNESKCVYNLSSNYPTNYDSKRKKWSNYYFQNTITIIFMIFLPILVFCKARNNYSQFKISLNNEEIVKTYRQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C459</accession>
    <name>A0A0N5C459_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C459"/>
    <dbReference type="WBParaSite" id="SPAL_0001274400.1">
        <property type="protein sequence ID" value="SPAL_0001274400.1"/>
        <property type="gene ID" value="SPAL_0001274400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312:SF8">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312">
        <property type="entry name" value="ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001274400.1"/>
        </source>
    </evidence>
    <sequence length="928" mass="107576" checksum="39AE55E78A15EEF9" modified="2015-12-09" version="1">MDVKIKRYSDRLNIRGFDSWEAVLISDNYEEVDKALSKLKKLLSKKDRIIEILDDSKEKSGVFYVLIRLMLNKALSNELSQKTIVLKILQETISIIANCCFFSMTACMCLTKTAPNIISIFDKLLNLPQKGDSVKAGILRLIGNLLETKKAFPTITSNLPFMEKLASFINSEEVKLQRNSIRTFKILCKNGISKRIIDCNAVAELASLIISDKFDLYSDDILFMLSFLARTVPKDTGRQLATPECSNFLFNILLEQKSEEYKYEKWIEPICSFLNRSYEIRESIGRVGLTKLILEGKNCISFLRILTFFAQDAWGRVTLRENGGLDIIIENLLCSESINEKILLIQSLKNLIHDTVGISYLCQSQKFFETVLIHVNSYITANPLDCKLELKDKSENIIQKDSSPFHTINANNVLLSNFYNQVYTRSGYLISNRASRSPSGHSRSNSLSPTRSVFSSPERDILDFEFEEGDEIMEMQESKDSLQQQNSEQMVVFGEFFLMSWQSHDENNHKYLARSEIIEMWVNYLSINLPCDSKAGRAMKRLARSCNIISNLLKLKFHILILNVLIRRSCMMHLLAKECKHCTKIHRYGKDLYRDFSEHVDTDYGWSYILIDLKQSNDDLKINAMIASVALIRTVKRRRNYFETYKPIKKLIEKCKVILFNQENFDMDNSLGEPNKEILFQIMISFGTLISKNTFDKLFFIDDIYKECNDLIDNGEISKESNCCSVPVSQKEGIEYICFENSTINECIIIEKDILCKNCTFYQAMFSSSFIEAQNKKFKFNFNEVISEMVSWEDFKIFIHYCSGCTDENCLVIKTPQTYVSLIYLADYFSYEFLTNKLIQFGDTLQRMFSGEDLKYIIPLVRQCPHIFSKLSVFFFINFLCYTEKEYMFEIFNSLINNPELTEEFFKELEKFLSKTFSTSSLTRGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5F7</accession>
    <name>A0A0N5C5F7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5F7"/>
    <dbReference type="WBParaSite" id="SPAL_0001318500.1">
        <property type="protein sequence ID" value="SPAL_0001318500.1"/>
        <property type="gene ID" value="SPAL_0001318500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895389" evidence="2">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001318500.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18978" checksum="77DF3DF26D068F5C" modified="2015-12-09" version="1">MKSIALVFLIHFLLTEFFGLTRCLFLKSRDSLSTTNSNGGSFPEIVNYLLKRKSTDSTSKGNSKSEKETNKRKRRPRNKKESYEDRMLKTLAESLANLTSNLASFMLDVNSRLNNVPTIPSSKTTNSTTLTAVSTTKKNTKSPKKPKSPKKSKSPKKPLRSKPSKKSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5J2</accession>
    <name>A0A0N5C5J2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5J2"/>
    <dbReference type="WBParaSite" id="SPAL_0001321900.1">
        <property type="protein sequence ID" value="SPAL_0001321900.1"/>
        <property type="gene ID" value="SPAL_0001321900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895392" evidence="2">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001321900.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18701" checksum="4594B6A6EE865B06" modified="2015-12-09" version="1">MKYLISFITLAIANFFVLTDTKFSYDPFADLANLARSKWEPISKTGRSLIAAIWAIDNYNNDNKVKYKLNKLIIVEKAVQPTLKLRIFFTACTKAGKKRKGRKGKKTCDYFRATFEKFPTTISPVIWVRKLSRKDERPSKPSKKNYNKTSKTYKKTRNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5T1</accession>
    <name>A0A0N5C5T1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5T1"/>
    <dbReference type="STRING" id="174720.A0A0N5C5T1"/>
    <dbReference type="WBParaSite" id="SPAL_0001330800.1">
        <property type="protein sequence ID" value="SPAL_0001330800.1"/>
        <property type="gene ID" value="SPAL_0001330800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001330800.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="40074" checksum="C2C2C0B5BD188663" modified="2015-12-09" version="1">MISAKDLQNDIAQYYKGDYSEFCVTTFDIKAAHRNFKISEEQGALLQFKTEVGVFKPTCLISDLNASAFLFQETLHKHTLSFKYLRFFADDGLLFTKRSEHAQDLINIFKILLDIGWQISYDKLQLMCKQVSFIGLLISSKGISIPQAKIDEYKRFNKLKILAALKIFIHTISFHPSMLPEFSILTEQFYKMKTFKWDEKAEHNYNRLIELLANTLYLQYIPNQITHFSVTAAVNNRAITSAIYWHSENEKGLLDLRGRTLKAAECNYIEYNKILLAVKEILEANKKIVYEYPIQVIFNKQFIAKFLEKHSEFFTTQNTFQRLRLAIEDFNISYKVDKIRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6R4</accession>
    <name>A0A0N5C6R4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calpain-15</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="SPAL_0001362900.1"/>
        <property type="gene ID" value="SPAL_0001362900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000010">
        <property type="entry name" value="Calpain 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF382">
        <property type="entry name" value="CALPAIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="14">
        <location>
            <begin position="210"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001362900.1"/>
        </source>
    </evidence>
    <sequence length="799" mass="91553" checksum="32B7B3B2D228B179" modified="2015-12-09" version="1">MYPILSNFGDLNVTNEWSCPSCTLLNPINVPVCGACGCNIPNLGMRVVNINSSSNLPPLSAFTSMVRNLRKSTSSMISHNINKFQRDVLSNSNNKEFFEKNWKCIKCAFINERSKIYCEVCNYDRGTLNFSNGEYNICHNCDFHEIYDLGKKYCSFCLGKLSRINETNKSNCNSETSTLLEYESLTHEQSRQIKDIYKNIYDDCVKNNVPFIDDSFPHSKKSIGENIISYHGRQLPTHIEWLRPAQIFTKDGCSYRWAVFRDNNLLTTDIEQGALGNCWFLSALAVCTERFEILKKIFITPNYEHNGIYILSLCIDGMWKSIIVDDFFPCSPVNKRQIFAVGRRNQLWVPLIEKAFAKAYGNYANLSAGTSAEGFSALTGCPTQQIDLQNEMFKECSDILWVKILSAKEAGFLMGCSAGNQFISDTEYLNVGLQKQHGYSFLDAVTLSNGKKIVKLRNPWGRFVWNKEYSYNWKNWNINEKKKLLPYGNEAGIFWMPFESFCKYFTSIEICKIRNNWKEIRIPLKTCYDWSSSFALKTVKIIVTEDTEATFVLHQSNSRSKNSLHDLLIVIHEENTFYGGPGKIVGYSEQSLLPFVVTEDVFLKTGIYFVTYFSFYDYGNEFKISKNDMSKKCDLIISIHSSRTLHASVLPASFLFYQRSLANFVKTYGKFEAPSNANVIFYTMKKTSCGVITYVENIDKNRCAFVKCKVNNHINLLRTRQSASTYDVVPPNSGMIIHVFTQMEPSQSYSIGYTLKCYLQYFQKGIINKDQPSNLMNNHNNPNLDKPHLLSLHSPFPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6V9</accession>
    <name>A0A0N5C6V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6V9"/>
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        <property type="protein sequence ID" value="SPAL_0001367400.1"/>
        <property type="gene ID" value="SPAL_0001367400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001367400.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28396" checksum="430FA97BF0A651D8" modified="2015-12-09" version="1">MIPRRGSFQLDELDDDFGYVKKQPMSGIQVENNKRIYESTTYTADDNILVYEPIECTPNMCANPYVLLRFFELAALFAIHWLTQIVCGRDDCTMILNEFGYKAHAQGLVLAIDMLLAVIIVIIIVCYSLNMHKAYPDIILSIEKVHGTLGFVLLIICGIIGSIYAAQTAWDRELNRIGRATAGVRPQWIAASCLEFVLAFVYLADYIGQKKEGYPFSYSINTSKDRSKIEAERKQRMIREHKLRQQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7I8</accession>
    <name>A0A0N5C7I8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C7I8"/>
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        <property type="protein sequence ID" value="SPAL_0001390100.1"/>
        <property type="gene ID" value="SPAL_0001390100"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="DUF7583"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001390100.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32910" checksum="8C27DF8CB14B7480" modified="2015-12-09" version="1">XDKTEEISANDTSIKVKCDTTYLNIGYLIKVKYNGIHAGVEDLDSTDSLRGNFSKGENSISFVESNNGTTVISCIYKTLDGSITTTTKFVNKDTIALNAQRLADQILNNITSQHNKTKMLELATMEKTFVKQIDKIKEESEENQKSALQKFSDKVGKTKAISLIVGVILLILIILAVPVVILYKKWLNPFLIMLKHKRKYPNVYVFWDNLTNESFDNYCKIIKDKKYLSDKVLNRKVIQKVEGGEEVDIGISHLFDETLVDCYKNLFRKIQAHYIYTDAEKRKYILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7U3</accession>
    <name>A0A0N5C7U3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7U3"/>
    <dbReference type="WBParaSite" id="SPAL_0001400500.1">
        <property type="protein sequence ID" value="SPAL_0001400500.1"/>
        <property type="gene ID" value="SPAL_0001400500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001400500.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15058" checksum="5D8F57339160D793" modified="2015-12-09" version="1">MTSIAVTIAKTFRIKFEFKKNAMSSFLEELIRSAEVIHSNKTVTETKAVMFFIQGISFKCKEDLITNNKLPTMAECREFALEKDLRYDERSFFYEGKDMRTNQTNFRMYKGSKSKELVKDNKKMVHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C942</accession>
    <name>A0A0N5C942_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C942"/>
    <dbReference type="STRING" id="174720.A0A0N5C942"/>
    <dbReference type="WBParaSite" id="SPAL_0001442500.1">
        <property type="protein sequence ID" value="SPAL_0001442500.1"/>
        <property type="gene ID" value="SPAL_0001442500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001442500.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11050" checksum="42DF9C5B51A7D1AE" modified="2015-12-09" version="1">MSRPYKINFHRPMCFWNANEVEAWLKIKKPKLALRYSGIFINNYVTGRVLVDLTEADLAEIGVNNHEERQELLVEIKKGRLTSDLDEMMKLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9P9</accession>
    <name>A0A0N5C9P9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9P9"/>
    <dbReference type="STRING" id="174720.A0A0N5C9P9"/>
    <dbReference type="WBParaSite" id="SPAL_0001462800.1">
        <property type="protein sequence ID" value="SPAL_0001462800.1"/>
        <property type="gene ID" value="SPAL_0001462800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895580" evidence="2">
        <location>
            <begin position="20"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001462800.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74013" checksum="218D238EA0E81C55" modified="2015-12-09" version="1">MVINCLVLIFLSLIAPVYLQQTTTLPQLSEEEFAKKLNEKYYDGEALNIPIGEDAVHDLQKHWSEQAISGLMAAVSSYKMHLMKKDAKNELENCSKQAYNIKDHAKCVSKALETIESKKRNRWTVFTGKSKKVSSKIVVERSKRDISNYKIKKMDSYKLKDKTDQGVLTTLAKYLQETIRIVKNKNETKSWRRVINEVKTMGKEIEMEESIQEQNMKKFGNTISKNLLKKIKDEKDAKVYQEKYEKVKDIRLPLKFLREAVKIGMSLSGANTSNFDSKTIKLLSPRFLSLVPDQTGNDTVNLLSPSLFSLHSDGSNDEATFSLRKLLGIVTPNDQDAWLDFIVEAAGVSDSIEDKQKLLKEKRKKEMVGMHGEKLYFTKENVTKRYGDEEKRKIEVFEKLSSTYSKKQITDLDKKGFALMSKSQMETVYGSGSPYNSSEALQSLADINEKNFLEIVIKTIRDIADGKLESNYDIKRGNRRKRAIVGSPFVLSPLTFAGTALSQAVVLSPLVLSPITLSPAVLGPIILSPWVFVPLVLSPRVLSPLVLSPLVGSPIILSPLVLHPLILVPGVMNPFVLSPFVLSPFILSPQALTPVILSPFALSPLILTPMVLSPLVLSPFVLSPIILSPQALFAVVLSPYALSPLVESKLIASEVVLSPSWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAR4</accession>
    <name>A0A0N5CAR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAR4"/>
    <dbReference type="STRING" id="174720.A0A0N5CAR4"/>
    <dbReference type="WBParaSite" id="SPAL_0001498300.1">
        <property type="protein sequence ID" value="SPAL_0001498300.1"/>
        <property type="gene ID" value="SPAL_0001498300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001498300.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13756" checksum="942FA5EF1FB85BFE" modified="2015-12-09" version="1">MLMYVYSQEASNIGDIATELLEIGDKYELDGLKEIAENSLCESLTVENIFQPFILSERCSAGSLKKCCMDFILQHGECLTKTNGWREIVTRHPFLLESLFLKLLVRRTSRQSTTEDKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBT2</accession>
    <name>A0A0N5CBT2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ethanolaminephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBT2"/>
    <dbReference type="STRING" id="174720.A0A0N5CBT2"/>
    <dbReference type="WBParaSite" id="SPAL_0001534600.1">
        <property type="protein sequence ID" value="SPAL_0001534600.1"/>
        <property type="gene ID" value="SPAL_0001534600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000016">
        <property type="entry name" value="ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF71">
        <property type="entry name" value="FI05338P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001534600.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48735" checksum="9EE5C62EDDEF2B25" modified="2015-12-09" version="1">MGIFDYKYLNSAKIHGFDNYKYNCIDNSPISVYISHPFWNWFVNFYPKWLAPNLITLIGASLVMGCYFLVSYLDPHITRNSYKNVEDPIPNWFWLLAAVCTFLGHLLDGTDGKQARRTGASGPTGELFDHGLDSYATVPFTITIFSIFGQGIYSTTPQRLLGVLISVQLVFIVTHWEKYNTGVLFLSWGYDLSQYGLVLFYLFTYFNGYQYYQYEPINGYTFVQIFEIGFYLSCFISFLMSFYNMYKAYFIELSGKQKNFYEFALPMVSPTILFTSSVIWANLSPSHVIVLSPRIFFWTVGTVFSNVAVHLIISQMSCTRTEVFNKLTIAYTIISFLCISGVFGDHELNILRISGIIFTLIHCHYGICLVRQLCEHFKINAFNLDYLNKNDSKRNQRTSLKVYSFPEGVKRYRLLSNCEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDB6</accession>
    <name>A0A0N5CDB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autotransporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001586100.1">
        <property type="protein sequence ID" value="SPAL_0001586100.1"/>
        <property type="gene ID" value="SPAL_0001586100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001586100.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="55343" checksum="9A059A8011F42655" modified="2015-12-09" version="1">MIKDNRKNYIFFVIFIGFIFIPLFESRLYFDKKEYGKILNKRQTVVSSNANATGQGDKVNTNAEAEHYKNSEGVIGVNTSSTGDASGSGQTGVNNQAYGSVGEKEVGAVGNSGALGADSESQSNINAGIHGDRWSVESFQHAKGQGVGDTGAASNGIIEMTNGTASSPYNSNNTQSSAGATGSLSSSSEIVSSQVLTWDAILLQLVGSAVAQGLYNAQANVDLGAGNANNGVQVNGIVSGDNLNGGLVNAQVNGNALMNNSNHELVGNMYGSVNGTGTSNLVGASNLQSNSSGVSNSVQSFGDGKVHSDGYNQITLNSNTNTTNSQNIEGSYGNMIVNSTATGANTNMTISGGLKGNTGNDSTTAIGDGNILSQGSDASNSSMLVHSNLNPQGDINLIVNGDGQALSSGGETGSLNMVSNGNVSNTDGVLNIGTASGSGSGTGGKVNVTGNNFLNINTAGASGNSYMGVQAEGAGNSSASSQAKLSINDGSGPPRDSSAQGTVSATGDTSKVNSYSVITDNNGVQSLINQQTASSSGKGSSSASASNSAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDD1</accession>
    <name>A0A0N5CDD1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pru domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDD1"/>
    <dbReference type="STRING" id="174720.A0A0N5CDD1"/>
    <dbReference type="WBParaSite" id="SPAL_0001587600.1">
        <property type="protein sequence ID" value="SPAL_0001587600.1"/>
        <property type="gene ID" value="SPAL_0001587600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="59"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001587600.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21308" checksum="D0E63037658D4DBA" modified="2015-12-09" version="1">MSKSRDLSLSPSEKDSKTLISQDDSLREASLNRKKEILSYKNSSKKKFILFHESPQILRPNRQMYTIKAGRTRMIRNISETDKVKLVCSPTPGIIRLRVDSKGFLLLTWENRITRKREFEFRPIPSTCCFKKIKECNDGYVVIFKDKMNKNVEFFWIQEKDPEIIENFLPKVNQILQMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDZ5</accession>
    <name>A0A0N5CDZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fam20C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDZ5"/>
    <dbReference type="STRING" id="174720.A0A0N5CDZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001608500.1">
        <property type="protein sequence ID" value="SPAL_0001608500.1"/>
        <property type="gene ID" value="SPAL_0001608500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="266"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001608500.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="60245" checksum="72D0B3D63E60A3D5" modified="2015-12-09" version="1">MQTLHFHTNRIFLLVAIFFFIIFIIIAHHKLLKLIDENDQGFYNSRRNLYPNNKGSGGEKHYGEQASFPKQGLPHINEEIVDYKSLFVERLIDTDVVEKIQNYMKEIDFKQLIPNECPINITLEDHFKMTNHNKTPKDDSWEVFYSKISSCNLYQEGSYMNELLHDLNSMEIKSVHIMEGGTQIKLLFTFVNGKQAVFKPMRFGRDYETDENHFYFGDFERHNAEIATFHLDKVLGFRRAIPTVGRVVNLTSEILEKAEKYFKKTFFISPGKNLCFVGKCDYYCDTTHAICGSPTLKEGSVQVFLPDDNAVPRKHIRSPYRRTYSKKRLLAPWQTNMQFCNWNVKSKRRFAHGRKILDMIDLHIMDFLIGNQDRHHFETFDIFNDAQPYYIHLDNGRAFGKTTYDDEDILLPLRQCCVIRSSTLIKLMTLYTGDKGLTEELHESMSQDPVQPILAYKHYTSMERRLDYVMKKILECLDKNSDNPGNVIMAEYHNDRVAMPRDGEHLDDDDVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEB9</accession>
    <name>A0A0N5CEB9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CEB9"/>
    <dbReference type="WBParaSite" id="SPAL_0001620900.1">
        <property type="protein sequence ID" value="SPAL_0001620900.1"/>
        <property type="gene ID" value="SPAL_0001620900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1233"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1783"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2533"/>
            <end position="2619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001620900.1"/>
        </source>
    </evidence>
    <sequence length="3605" mass="421055" checksum="FF96AAFE5B07508B" modified="2015-12-09" version="1">MYKENLNKEIIGKISFQFNPPAGELKLDDLKKSFGIGKLEARVPHFGIGKTTCKFKYSRDIFIPYVGSSLSYSLNVVGRNINGQRRLISSPERDRKSKRKDIINIIMGELEDVDMNVKYCLSREKDIIDFPSWNNQLNGIESRVVRMNLVEYDDVVKIILDEIYDLWPKWNLRARGIIVKRQLQNFRKIVIEKCIYFDKCPFWRNEFSFSKIKCDIECKTRIHYFINHNFFEHIKKNLIFDWENFFENNNVHGGRSLEELVEEVDNFIMKSTRITRFHWPLSICKTLLKYSQEWIHWMGEKSEENIIKFFNGIASLQRHLLIEVIKENFKNFLKYRSSDSTNSADNGNQCLDDSDNELILYNVVKQISILGDEIPRCETKLFPDIFEKNKFINCGCDVNLPLFRIRFHDIFVPFEKEYIELRKRVDILLAENLESDEWKKLCLDCLDYQQRLKIKGSTTFSESIMVNYIAKKVKLQDNTSDMIGELRRHMDDYLSMQMKDIIDFYGVASSKLYGKSEIDQICSIAQVKEKDLPILRKKLDDVKKAFIVVLDLDMANETIFLKLSNILHLPKNLTLLIELIQNILNVDQEDIENQIAIQAKEMYEEVSALDKEVHFARKKYVNIRYHQEISRVVARFEDAERRLKVIIEKFPILQKRMEVLDLEPLNIDVEKLLKRTSVFRVFSSINYKISQFYEKSMCNLVTEINFKQFDDNLIEMNKNLDYLRNEKEKYNDLVLTNVIDVVFGRMEKMINECNEALPILKMLCSEGIKDRHFTKIFQSTDNPDITKENLTVKKLLELNLIEQVNVCEEVTEIANKELRLEETLKQMQQQWEDLETSSFNTILSDGVTQGLLNEHIIKTQTIISSPFAEAIMDQLNNWLKILFETSDTLKLYNSCHQKWQAMEPIFVNEDIVYQMPDEWRLFQNANNNWHLISSKVINCKQAIKIVESNVKEDLHKLLDDMNSIQKGFEKYLQTRKINYPRLFFLANTELLEMLAKYRNTKSICNFLPKMFSSIYDLTFNTRGDITEIINENNEKLVLCRPIHASLSKSHLEKRLNELEKEMTWSLKNNLKKLINNNGINFDKPEQVLKENLDQICLLYYRLSITMCIENGINNSKINTSVNTLLNFRKFCQNLLSVNDSMWSKRKLLLQSLVVEIDEYVNICRQLTDSEVYLVDHLLWKRELRYYWKNDNLFIRILHLNIIYSYEFLSITQLITPTVQTKKLWRHLLYSQTKSYGNIICGPPATGKSESCKTLAALLGRHSFSFNCSEQVSRSQIEDLIAGTVLSGTFLCLDEFNRLPTDTMAWFANHVIGIYQSISSSSMKYEIMGNEIVLKSNFLIAVTLNPDKIGRYPIPDNCTSAFKVIIATSPGLLTICESYMKMNEFKSYQILAKNIVSTLNILESLLTPMKHYSFKLRTIFSIITESVRNKKNKILEFDAVKMAMIFILKPFIIERDSKIFETILRYSFHEKIPNRRNSYIFHDEEKINKTFSMFTKELPFKLSGKCKQKCFEIVEISRISKSLLILGRSLTGKSTILKIASEILSQTEEKEVIIKTFNPSRFSQDSIFGSFRQKYNDWHNGFLVEMLISGLGSNQELWIVFDGLLDSQWAESLNSLLDNNNKLNLANGESVFLKSNIKIFFETDSVEKIAASTISRCRVIDTNDIGIDLSSNLIDEEEHKPIMKIVSLLKFPNNYIKNLFYIQFNSILNAYRNFWASSSYNTLIFEIQYIFQNLIIPKQDYLKNFNIEKIKMPKPLHSQKSPTLIFDNSDLNQLNSILSKLIFGNHFLILTGTFGSGKTTFLNQFASSLDVSLWEVYKFDMTIETTATIFLDSLLQTKLFRVTKNHYTVPGNRNILIIINSLNLVNDTSRNSIWEFLRCCYDRKIIQHVDGSECSFENVYFVGEYSTRYVNDIVEKIPQRMRRYVLPLSFPDISEYKRPESTLRLLVNKLSSLAPDNPIIFNEIRYFYRYLSENQKNAYRILSDYFGECDDEGNDFVIFKNENKQKIEVLLNSLKDYLLKKRKDFTKLFQIIEFPITDTICRRIAYLWKIFLVSNYYSIIFTSYNSWDIETVSFACYIGQINFELIYPDISSAHWDVILKKSIYTAVVEDKKILLYIPDNIYDKRTMDVIIKDVTQLVNEGLPIDLFGPKAINELADSFYMRNSIKASSDKLENQEISEVEQIKATTNEWMKYKCIQKLLKLNLKIRFAVRDDTNGLGDLRSIKDYFIVEDWRKWTDNDFLDIGISILEESGEFSDGQSSNFVHRMINIHNVIRKVDHSISSKHFIDFCKTYCYLCKKMRIGIETLDKRYKAGIKRIVKADEQMNFLQQELLRLQPELLRTSLETSQLICIIEKETIEVENMREVVAANEFKANTAATNAQSLKAECENDLAEATPALESAVDALQCIDQKDISMLKAMRYPPSGVRLCMEAICILLEEQPTKIQEPGKKPTFDYWVTAQKLLSDMHFLQRIKTFEKDKIPLKVIRKLRREYLSREDLDPENIGASSAAAEGLCKWIRRIDTYLKISEFIEPKKKKLREAEALVKSEMKLLESKRKALIEITERLQKLSDQFSQMSQRKEDLIENISNCEVKMGRAERLLNALNMEKVKWRDKITELKQKSEVYKYNMLVGGAIMEYISNWESNRKQEVINEITNISGSKEIFKMSMFFDPTSKYLNCQKDLINTFSIVLSSRKVPLVFDSQGAVGRNISYMVGEELITIDCHDKNLCEILKNCIIDGKIILIDNVINPIPLVIHQVCNKQLFIINEGKMLRYNNEMIPYNDNFHVILCSSQKVNQFSSDFLSYLCCISITINEEIIKNNLTEVLLKVIASNQMSRKAILDKSNFELSNKLSDIEENILLLLAKSKDLENEASIDMLNEMKTITLKIQENKKEIYLINEHLTQITNSYVSVINHTIKIIKISMNLPIINGLYTRSLNFLIDVFRDALINVTSDIKETNNDQLRDDISKYFVQLFGMALFKPHQQIFEFVVSNLPNFDFFDSSSQMNLDKLFYEYEKFVKLSSKQNNELFENLKKIYNLNKPVLFAYSSSISSDYLLQSLHQLSMSVNINRKCSIISIEEIDKIKWNKYFENGDWIIIENCHLGTPQNISQLTLILKNLSNNLVKNHSDQFRLFATISNDGMTEDCALFDNITVVAMDQVFTIKSFLKFCYTNKVICEIHDNTETLVFRQTLYKLCIFHYVLIERSKYGIYSWFNEFSPTFTDFISMINLYKENMTIINHDYLESIYQNILELTYQGKMSDENDLLTFTVLAKWIFIGLNKFDNLIIENLLNIDISHPSEVIASKIDNLNFCQSLHLSGLNKRIPEIFLQQEIITHRDFLLKIIGKSSKVLKMTDIFKRGNQNNNITENDDLAFILEKVPSSYKLKNLKHLDYVGFCITNEINFLKTKIKDSSKHFLRIQYLESILLTKGIRKIDLRKILKPISIIEAVKLDFAKKYDCNIEEIYCYGTIKEPEDKCHVLELQGCYLIGCTYDVKSQKNMYTLKELSSADRASTPIESIYICLKNVSTNFLNALSKKVIMSELGLNKKHQENHQSKVFKEMYFQLYHFDNVLNEYIQVLPVMIHSNIPESHWSLRGVKLLTSSPKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEM5</accession>
    <name>A0A0N5CEM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEM5"/>
    <dbReference type="STRING" id="174720.A0A0N5CEM5"/>
    <dbReference type="WBParaSite" id="SPAL_0001631300.1">
        <property type="protein sequence ID" value="SPAL_0001631300.1"/>
        <property type="gene ID" value="SPAL_0001631300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097524">
        <property type="term" value="C:sperm plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043401">
        <property type="term" value="P:steroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF45">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="143"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001631300.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48379" checksum="BC0F15D29EC5D683" modified="2015-12-09" version="1">MWFYENISKSFNGIHVYEINIDSARLLFICIFFFFLLKFLKAHSSSSKPLITISKNKNKEDGGVVSIQDILQNCSILNEKYVAPLLWGKNGHIQTGAYGILGHSELQRTYNERCFVVLDDNTTVVYDIFEPTSSSSHGKNITLALCPGIANNSESNYIRTCVHYAQQHGYRIAVLNHLGSLKDVQLTSNRIFCYGGTKELKAMMFDLFKKYPESKFINIGFSMGGNITTRWLGKLTEELSDRIICGMSVNQGYCAVRSSSLFHDWENGRRLYNYIITEKVKQILWKHYDMAVAPHVKSGLIDEAKIWAASSNVTLDEHYHRRVYGFKSVDDFYEWCGSLKSIPNINIPMVFVNAEDDPIVPETLYKLVQDICEKKNNLAHILTKHGGHLGFLEGKSLKPNSVTWLDRFIVQYADASVIAYYSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEN9</accession>
    <name>A0A0N5CEN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEN9"/>
    <dbReference type="STRING" id="174720.A0A0N5CEN9"/>
    <dbReference type="WBParaSite" id="SPAL_0001632600.1">
        <property type="protein sequence ID" value="SPAL_0001632600.1"/>
        <property type="gene ID" value="SPAL_0001632600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001632600.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13225" checksum="73729CC76AEE17CF" modified="2015-12-09" version="1">MSKDKEKIGESEVCSEEVETSEGEESGDEVYEVEYIIDVKVANDGTCKYLVKWKNYSHLDNTWEPIENFCDRQCVDDFWEARRKLALKRIKEFDKKFNGKFDTTNFFKGTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFN3</accession>
    <name>A0A0N5CFN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFN3"/>
    <dbReference type="WBParaSite" id="SPAL_0001109200.1">
        <property type="protein sequence ID" value="SPAL_0001109200.1"/>
        <property type="gene ID" value="SPAL_0001109200"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001666800.1">
        <property type="protein sequence ID" value="SPAL_0001666800.1"/>
        <property type="gene ID" value="SPAL_0001666800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001109200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001666800.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18570" checksum="46F1FD7D82F6AB82" modified="2015-12-09" version="1">MAVVDESSRRLRSFSDSCDFRESRVISDSKITRRRKNYKRKEVPSDDTTVPDSFLSDNSFKAESARENGTYVEKELLSSTKNEERIERYFDDTLVHTEATSKVHKLGKNVKRREDLEKIKDSTDKVFFDMANNCKDRKSLVYFCNTVASFCAFVYQNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGS7</accession>
    <name>A0A0N5CGS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGS7"/>
    <dbReference type="WBParaSite" id="SPAL_0001705200.1">
        <property type="protein sequence ID" value="SPAL_0001705200.1"/>
        <property type="gene ID" value="SPAL_0001705200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048634">
        <property type="entry name" value="SecD_SecF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF102">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="347"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="963"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001705200.1"/>
        </source>
    </evidence>
    <sequence length="991" mass="113138" checksum="D402C2F3F1E80B58" modified="2015-12-09" version="1">MSLKIEKTTLPNEDQDQERAIFILSTKVDNEKDLCNGNDFLLTPRNKVNSLPIHGTEKVYIFNGSKAEKFLLFCKQHLRLRNLFYWLGVGIASYPTAFIIASIIIASLSMGMINIQLKDRTNDGYTPSTSRAKYETDVYKEFFGAVGDTLPTSLIIRAKDGGSMHRLQYLEEADKLLTFLHSNLSVPYPSDDNPTEYIKYQDICGAFCDSNIIIHYFYLSLLNEYNKNLGGKKINKLTYPRSKISGYIFPLEKNFFGVEKNHYTEEEIDKDEELRNLKNITDFDYIQMILAPFLGNKSSPENENKMGVWDLGAYHYLQNTYKSNYIDVVSIGAKIVDYEMNKSSQKTIPYFAFGFSVMFLFVFFTVFSSSIYFNALDLGKILAAFGISICPVLAVTTTFGCLTLLGFRTNSVMLIMPFLIMGIGINDSFLIVHSFLKPAYRKLPSTDLLGLVFEDVGPSITITTFTNVITFAIGALTPTPEIALFCLATAVALGLAYIYSLILFGPILYYTSKCEIMRNSEKECTKKDSKFIECLKRIFKKLRVLYCNIISNHWFATLLLIGSGVYWYFAIMGTLNIQSRLDTEKILPKDSPLVEPHKLIAHVVWNEYYPVTVIVNNPPDIRSHDDVRIFYEMVSDFENLDKCKGKEFSMVWLRSYEKYVEDSKLFIPWDYSGEDEDNGSNSNNNGTDEKLNYKDLRGFLKSPIEKGWNAFIKLKNSSDYLSNNPIESFWFLVAYHNIDNWDDRIDIMLKWREIADNYPIFNVTVWESNGMFVDQMLSLKTLTIQTTIVTLLCMTIVCAIFIQNPIAVLFAVLSIASICIGVLGFLSWWHLDLDPVSLGAVLMSIGMSVDFTAHVCYHFQLKSKKILKGTQITKQPMNSTKEKLHHTIDSVAWPMMQGGISTVLCVMPLICLKDYIPLVFFKTICLVAIWGLFHGLVLLPTFIQYIPRCWIEWSCYRYINKSSSMPDSSSTAKESLEVSLESNEKQQQNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGU0</accession>
    <name>A0A0N5CGU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGU0"/>
    <dbReference type="WBParaSite" id="SPAL_0001706500.1">
        <property type="protein sequence ID" value="SPAL_0001706500.1"/>
        <property type="gene ID" value="SPAL_0001706500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001706500.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31982" checksum="5A9AF2BA2A2797A1" modified="2015-12-09" version="1">MTFRSVRDENSHVIQNRYNEKSAYFECDQDLSRFLKMSDMRDLDYLHVSGISDNMNIFGILNRSFQIGTKTGVLSISKLSNKDCPSFRTFIRKFLSVKEIVIRHICAPLMGSEDVCSLLSSLSSLNTIEYIKIFECHNTIILSADFVVNLLKNNPNIMYLDIGSSNIEFSESILKEFFTMEQPHIMENECNNNEITLALYFGGELKKIHDILRKDLSKIENVMKEVTSNVLFPEEYKVYVSKLDCKYCLKNRHKIMRRVVVQNYEDTCQRLDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGY0</accession>
    <name>A0A0N5CGY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Voltage-dependent anion-selective channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGY0"/>
    <dbReference type="STRING" id="174720.A0A0N5CGY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001710500.1">
        <property type="protein sequence ID" value="SPAL_0001710500.1"/>
        <property type="gene ID" value="SPAL_0001710500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001710500.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31490" checksum="645C43CD38A1EB81" modified="2015-12-09" version="1">MTQPKYGDIGKSASDLLNKGYGIGTFKIKVKSGIAKDKPYEYKTSTIHNFKSQILDYNINLKCNLPNYNMVLSEKWTPNNTLTTGLELVDYFFKGLTIHLESNYNFMNSNRSASIKTDYISPSYRLQNKINLLGRPILNSTFVVGNKDAIAGVQITTDLQENKIKAYNVAISRIYSNSEVNFFIKNDANVCGSFLYKTAPNLDLGGEVSIKQNLGEVYYAIATKYCTSNDMVIKAKVNNDSCVSISVKNKITPYLSLSGATQFPIYSSSNTSYKIGLGLEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI13</accession>
    <name>A0A0N5CI13_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI13"/>
    <dbReference type="WBParaSite" id="SPAL_0001747500.1">
        <property type="protein sequence ID" value="SPAL_0001747500.1"/>
        <property type="gene ID" value="SPAL_0001747500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF14">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001747500.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32964" checksum="FE6F08FD585E6448" modified="2015-12-09" version="1">MVDINLIVEIIQLIYKIPSMLLMTLTTYAIIKEIKNKNAYFNKQFYTIIVCKLTNEIIFVMTIFIFFKLPKWGFYNNFLENNDWTATIFYILAAQQTTFMFLITLLISVNRYIAVKYPLLYKLYFSKAKIVFVLLSFIMLSTMIGLGNIFFDARYKKSDLFGYLTPTLKSKNLIYYQMFGQIFLLGNISIATFAFNVMAILALKKLNKINNKFKKQFYYIIYSIFTFITLLFVEAFFACRFIAVKYEIRSFARIIYFLQIVAFDLTSVGDFYFLIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI43</accession>
    <name>A0A0N5CI43_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Thioredoxin-related transmembrane protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein disulfide-isomerase TMX1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Thioredoxin domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="19">Interacts with ATP2A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI43"/>
    <dbReference type="STRING" id="174720.A0A0N5CI43"/>
    <dbReference type="WBParaSite" id="SPAL_0001750500.1">
        <property type="protein sequence ID" value="SPAL_0001750500.1"/>
        <property type="gene ID" value="SPAL_0001750500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02994">
        <property type="entry name" value="PDI_a_TMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000117">
        <property type="entry name" value="thioredoxin-related transmembrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 25" id="KW-0732">Signal</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895990" description="Thioredoxin-related transmembrane protein 1" evidence="25">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="26">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001750500.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27455" checksum="0D07EC2931A10120" modified="2015-12-09" version="1">MNKVMKISYLFFLLLSISTFVSCSKKSKNLITLSEDTWKQILKGEWMIEFHAPWCPACKDLQKSWNSFADWSRDLNIKVAEVDVTTNPGLSGRFLVTALPTIYHVKDGVFRQYSGPRDKTDFIGFVEEKKWKNIESIPSYKNPDSPQMNVVALFFKLSMAVRDLHQQLVEKHGVPAWGSYALFGFVTLAVGCVLGFIIVCIIDIVFPTGGAPTSTDSGKKEKKEKKENAKDDGKKKTETKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIJ7</accession>
    <name>A0A0N5CIJ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001765200.1">
        <property type="protein sequence ID" value="SPAL_0001765200.1"/>
        <property type="gene ID" value="SPAL_0001765200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001765200.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="47229" checksum="66ACFB73390724F6" modified="2015-12-09" version="1">XNPPTAQAMENEVARAAGISSLNRGPLSLPELSPITNEESNENQKIKPIPLPSIEKSGETSRSFKSDESSESLIDSSEITFGNPPPKSDEKIKPNKSDEFDSNSKSKEHINVEIEPPLEPTDEEISSLSRNHKKKKVKVEEVDSGDSGIIPQNSGLRPVAPPSEFGSTGGFGSGFGGGSAQIPSGFGFGGGMGSPLPKPSKTPSSPVNEKTIGMETNKDENDDNDGDGGDEEDKEDTAFGRPKGPSPDDGSSEGPPKPKGPNFNQEELFTGDSAFNINSKGPTGDGYGPPISSGAAVPPPVHGINYGGGAAGIGGMGMVESYTQNPPTTVKPSALLNILNKADQGINQAITHFERGSPVETAAIDILEVALGSQRLDSQAKLLGHVDRTFGLDNLQRLQRWANTGGALDMLKEQFAKIAKNYRPPADLLPTIPPQLEYLFSPSNNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B273</accession>
    <name>A0A0N5B273_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B273"/>
    <dbReference type="WBParaSite" id="SPAL_0000017600.1">
        <property type="protein sequence ID" value="SPAL_0000017600.1"/>
        <property type="gene ID" value="SPAL_0000017600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000017600.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="19636" checksum="DA50CBF127D01B83" modified="2015-12-09" version="1">MGSGYNNGGYSSGGYAGGGYGSMDYPMGAGGMHGGGMYGGGMGGVLGSVAGMAAPMLMSGMMNGGGGAMPPMMPPMGGNTGGLDDNDITPPRGSNHNDHPSDKIDNKISNDGDVVKNRQNDIIKQGNGLGEQIQGQRPANNGNRRGWGLLRGRTNDIINQGAGSNGLGGQGTQANGNHLGLNGNRGKMIFQKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3G4</accession>
    <name>A0A0N5B3G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuropeptide-like protein 31</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3G4"/>
    <dbReference type="WBParaSite" id="SPAL_0000061500.1">
        <property type="protein sequence ID" value="SPAL_0000061500.1"/>
        <property type="gene ID" value="SPAL_0000061500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893690" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000061500.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7148" checksum="0441C29A9239C284" modified="2015-12-09" version="1">MNSKIILLLIACIIAMVSAQFYGPGMYGMYGRGMYGGYGRGMYGGYGRGMYGGYGRGMYGGMWGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B464</accession>
    <name>A0A0N5B464_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B464"/>
    <dbReference type="STRING" id="174720.A0A0N5B464"/>
    <dbReference type="WBParaSite" id="SPAL_0000086600.1">
        <property type="protein sequence ID" value="SPAL_0000086600.1"/>
        <property type="gene ID" value="SPAL_0000086600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000086600.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="65051" checksum="1A9A7D302D6C7C24" modified="2015-12-09" version="1">MNADDSFSSINGSDFDNLEDELNNDEKELDYYALLNVPRDATIEDVTKAYKHRCRIFHPDKHTDNEDKAEAEKLFLQLRNAFTTLTDPKKRAIYDAVGLEGLDICGGEIIEISNVSDDIRKEFEFLKRLREQELMLARVHPSGLFFVKCNCSGLFRRLKEERFLPTFTGISLSQNVNCSITMSDKIGLQGRVKAFNGRGDGYFRIVWNKSYSQTKDIENSVEIREDSISYSFKFITSVFSKSYISVQPTIEYLPYVGSFNPSLSFIYLQQLRSNVQGTIAYTLGTEISTLTTSIVISELNDPKFVANISLSPVNPNARFVYYKRYAENDALYEAGCTFSFMGCTPSLNFERKLGKFSKIGCGIQFSYPALMLIANFKIKTGLSTYQTQLVLCDDKEDISRAFIYGTLLPYIGFYIVKSVFYKPIEKFMRIFGDNTNDSQVYSFREQEAVKTCHLMRSTAERIASDEDRKHGLVIIEAKYGEMMNYGPYSNQYPIAGDKLIDVTIPLQAMVNDSQLRIYSNKSHLPGFYDPCPGKPKMLKVSYKFRDEMHLCTVADECPLNIPLSVHRLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Z6</accession>
    <name>A0A0N5B4Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0000114400.1">
        <property type="protein sequence ID" value="SPAL_0000114400.1"/>
        <property type="gene ID" value="SPAL_0000114400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="6">
        <location>
            <begin position="138"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000114400.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="57133" checksum="0B4E7C4C57CC8069" modified="2015-12-09" version="1">MLFRIRLKSQLYVLNLFEPDVLNLFATLKGYPDVEEIDEFFHQINTYTCLKFEKSSYDFKGIGIKFVLTSYNDHVKLSNDESKVTYISLRKETYKDIFKIRFYVGLAFGLIPEIQRIDRDRELILTLFETLKGYPDVEEIDEFFYQINNYTCLKFVKSPYKDVSTSIEIKFVLTDYKDHVVLSNDEKKPTYISLTKETYKDIFQTRLALGLIPEIQRIDRDRELQVHDNDINDAFKLFYRKSNYYYKFLKDTDYDFASATHFPTYFGSKDSNPTYIPLECQYKGMLESNRHFVYSDLRKLNNIYCKCLKRNSCNHGGYYYKKDCETCKCPSMFTGDKCQDIIEIKEDVGCNRGETTLIAEDREDEVIIENIKEYCYISIKAKNKSKVVQIIVEDAKIFNIEGRAINPRGEIKYRKDKGVEGLYIQHNVSEFFELKALSNEVFVKFHDPFSKSSLVFFYKQVDPTEDDSTKNSKQLIESCKTKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6A8</accession>
    <name>A0A0N5B6A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6A8"/>
    <dbReference type="WBParaSite" id="SPAL_0000159700.1">
        <property type="protein sequence ID" value="SPAL_0000159700.1"/>
        <property type="gene ID" value="SPAL_0000159700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000159700.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23991" checksum="C53D2D83FEB764DE" modified="2015-12-09" version="1">MFHRTICRNVILSNSSIRFCSFHRGGSNYLRPNLDRKPETFQLDHIQQRLNYTVPEMFKNKLDFTFYHKSVVLDDQIRNVKKYGLQSSMSYISHISVVGQSLFPHIHTEIISIVPILEDGTIHLRWRICYISWLSLFLNFKYFNRNYRIKNLKWYDGLSVFTVDGDGLVYNVTLQRIEQNREAEKRPMDRLKSKIWAPILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6K2</accession>
    <name>A0A0N5B6K2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6K2"/>
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        <property type="protein sequence ID" value="SPAL_0000169000.1"/>
        <property type="gene ID" value="SPAL_0000169000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="195"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000169000.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="62450" checksum="41AC1C688BDFC7E7" modified="2015-12-09" version="1">MVYKRFVPDPLSTHGSINDNEKNAYSVRSEDCDAGDLLVSYDHKTKYYDVEFGKQKKLADDINEYMEVNNCKSFVCIELKNSENIRIPSLLLSYVSCFVERILSDKHTTLSFMKAKEFGEKEMKIMMDFIMTGKLRYKIEDLVDLFSIAHRFEMPSVCTILETSMLISLKSNKLLLPIYLNYSAEYKNIISTKTKILLLEMVNYYFNEFITRQMFLKLTPQALVMVMSSDILKVSSEMDIFRIGVIYMSKKEIYGVADPIFNCIRFNHCGSEKIAEMKKELEKLNKTYLSYVFGCFSRESGRNMEGHDSQNSNYVFQRNFNQLSSRNTVNPKAQETSKCLESTIQYMIEELETKKKANQVTYNMIYRLKKEEVNNAKPPQRFKVLPSVPQFLMKMRAKGLKKQNSTNKEDSNDVITINPYQDIPRYNDRLFSSESMYEINKFKNVFDKNYFGEEVVEKKNTDENKNIVSEKIKRNPYYYAFKDRQQRRYTVDSINEINNLDFFNENNSNYEIGQPNLQEYLSTVNTPKKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7D6</accession>
    <name>A0A0N5B7D6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2513 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7D6"/>
    <dbReference type="WBParaSite" id="SPAL_0000196200.1">
        <property type="protein sequence ID" value="SPAL_0000196200.1"/>
        <property type="gene ID" value="SPAL_0000196200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000196200.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14993" checksum="6F81E5A2F163D91A" modified="2015-12-09" version="1">MSYRIKDVSTRLIKPTLQDIPLKELYEVISKWDDSWEHDGSVSIFDEGIAQYLLTDMLSHLKFYGAIFLDKLSLKCRLVPESEAPVDVLEEEYENHITFVYNGTGSVSEMEIAEKIKLVLRKRGFRFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7K1</accession>
    <name>A0A0N5B7K1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7K1"/>
    <dbReference type="STRING" id="174720.A0A0N5B7K1"/>
    <dbReference type="WBParaSite" id="SPAL_0000202600.1">
        <property type="protein sequence ID" value="SPAL_0000202600.1"/>
        <property type="gene ID" value="SPAL_0000202600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="64"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000202600.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51577" checksum="61DE6CB39F7EFCB8" modified="2015-12-09" version="1">MVTIANSNDSQSDISCAQAIEVFEKLNYYFVDEPVIANHKRAPVWLGIIIAFAYSMVIIFGAFGNILTIFIVLRNKSMRTVQNFFIINLALGDFMICTITAPITFFNISFTFWKYGNALCKFVSSIGGFNIFLSTFSITAIALDRYFLVIFPTQQQRQKFFSIVLFALIWIISLLLSIPIVIVSSSTMFYEVEYCNLTLYLCNENELAWEKMPFSKLSYTISIIVIHYAFPIVSMVFAYTKIASRMHERFVHRNNTKLIGEDANNRRKHVAERQRRTNFLLASLVLLFAVAWLPFNIFHMLLSLKVITYSGTLFALCHLMGMMSACLNPVCYAFFNQNFRNELFIILHKLKLRKNSNVNVVNRNDYSATVKKSTIGNTNNLHHKSVSTVVMPDNSLKISIDNKSKNRSISECAPDTIPMVPISSHQSTTEVTTSLVEDEKIVEEGEIEILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M6</accession>
    <name>A0A0N5B7M6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7M6"/>
    <dbReference type="STRING" id="174720.A0A0N5B7M6"/>
    <dbReference type="WBParaSite" id="SPAL_0000205100.1">
        <property type="protein sequence ID" value="SPAL_0000205100.1"/>
        <property type="gene ID" value="SPAL_0000205100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000205100.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15843" checksum="A3BDAF3F5130106D" modified="2015-12-09" version="1">MFNNEQKAEDNLLQSNSLNFTLSSLINEEIISSPQTTSSLSSTNSNEVQLLPSTSNLLDSTFKTRRKIKFDPKKEVPILENWYKTIKYPKSDQLKDFADYLNSISNRSLDDRITLENLKYWFSYRRVKEKKGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B807</accession>
    <name>A0A0N5B807_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B807"/>
    <dbReference type="STRING" id="174720.A0A0N5B807"/>
    <dbReference type="WBParaSite" id="SPAL_0000218000.1">
        <property type="protein sequence ID" value="SPAL_0000218000.1"/>
        <property type="gene ID" value="SPAL_0000218000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15739">
        <property type="entry name" value="FYVE_RABE_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000005">
        <property type="entry name" value="RABaptiN (Rab effector)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="190"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000218000.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43845" checksum="3477E64FE6A28585" modified="2015-12-09" version="1">MSEEENVETSSDSGGVTSTENDKQTSKSLEKKESIIVNNVHQPEVPVINNVENTIKKYQSDLSSERLYRIELETQMSENVIALEKKFKENEEKYKKLVERVNLMEKSYAKNIGTLRDELAKSNSVSNRLESDLLDLGNRYRNLLGINKKNAAKMREEDIDLPNDLNELQFYTLQLREQLIEVQSAREHEVNNLKAENTFLEDNIKDLAKDREELHSMLQIKENYEKCQHHIAHQKQIIKTLEVALAKERESTKMLENKLMESRQKCINLQVELDNSETVQRDFVRLSQSLQIQLEKIRQAEQEVRWQFEDDVDNCNGCEALFNKQRIKMHCLHCGKIFCGSCLSQSVATGPKGRKVRICQVCNTLLNRESAPYFSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B829</accession>
    <name>A0A0N5B829_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B829"/>
    <dbReference type="STRING" id="174720.A0A0N5B829"/>
    <dbReference type="WBParaSite" id="SPAL_0000220200.1">
        <property type="protein sequence ID" value="SPAL_0000220200.1"/>
        <property type="gene ID" value="SPAL_0000220200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000220200.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49683" checksum="036DB3717A4B3483" modified="2015-12-09" version="1">MFQYARNIFFIDSFRNVSTRAQIDAQIRALERTFVIDGGGPISKIDVCSLPANSPSEDNFAIGKCLTSDAILCGVFDGHGGYACSRHVSIRLFDYLCAAVLQKHVVQENIPLAERLKWFLTSTPLRVPQESEEKHRKNVQSFYNSFIKNHSGQYTVRKAIQSAFIALDKDIEKGALPDSRGIFSKQGASIAATGSCATVAHIRKSNLHVANIGDSVAVLGIKSHEGISSRQLSRLHNPDNADEVKKIRQEHPQNERGTIFKNGRLLGDLIPLRAFGDVQFKLTKDLQKIILSPLGYKIPSGLLTPPYLTALPDVFYHQLTPNDKFLIICSDGVFDFLDADTTVRIVHDHRCGIETLTPYNPQANSTLGDVVRDLEERRTGAHKNPIDKNSATHIIRHALGGVTKSLDEQYANLKTQLTHPQGVARSYRDDMSVIVVHFNESYLDPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8T5</accession>
    <name>A0A0N5B8T5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8T5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8T5"/>
    <dbReference type="WBParaSite" id="SPAL_0000245800.1">
        <property type="protein sequence ID" value="SPAL_0000245800.1"/>
        <property type="gene ID" value="SPAL_0000245800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000245800.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29635" checksum="34BD227B43F1EC44" modified="2015-12-09" version="1">MEHKSKTSVTVECTPAFDFSNCFRNQAMQKMGVKMPTLTSTGTTIVACIYKDGVLMGADSRATAGNITADKACMKVHKITDSMYACGAGTAADLDQVTKMLSSQMRLLELNTGKSARVVAALRHVKQYLFQYQGYVGAYLLIGGVDPTGPHLYTVSANGFTLSRAYSAEGSGSYAAISVLERGFKFDMTKEEAKELVQRALEAGMHGDNASGNSLNLVDITMNKTEFIGPIVPDFCKRPEPIELKYDFKPGTTHVLKTKVIKYDVIESMECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8T7</accession>
    <name>A0A0N5B8T7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8T7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8T7"/>
    <dbReference type="WBParaSite" id="SPAL_0000246000.1">
        <property type="protein sequence ID" value="SPAL_0000246000.1"/>
        <property type="gene ID" value="SPAL_0000246000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000246000.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51732" checksum="CA20C3DB74F0E09D" modified="2015-12-09" version="1">MASNTNECFLEEQLLLPQNISNECHTNKFMIKESIKDSPFGYIYKGSEFNQKRDIILKFISKNGYLMAREISQLISTWNDDKAKISSPAGNAKPNKNMFLDILEVQWNNEAKNCFMVMGKKLNNLVDLVGKVSKYDGWKGFYYFGLKTLAYLHQQGVIVNNLKTTSFWYAPSGDKGSYENEYDKVFIADYEFWCRFEDENKTCVLDPQILELSKQRLNSRPLSLTYCSLSRQKGEPGCAKSDYESLFYVYLELINGKLPWSTFPNNEVLVRNGKTAMRTPSYREFGNLDTRLYDILYIIDRMSPHKVPNISKLYNKFVGIVKTVSIQGQPQNADENNYFMVKVNAIKASKFTKEEPLLIDYYGKQNEILKKKPRCVQLEEKKSRLKNPYEHEVINDPFEEKLKILNNRRINDLKNVYINREKPKSRPDVSTTDIDTNLLQTKTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9H0</accession>
    <name>A0A0N5B9H0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9H0"/>
    <dbReference type="WBParaSite" id="SPAL_0000268600.1">
        <property type="protein sequence ID" value="SPAL_0000268600.1"/>
        <property type="gene ID" value="SPAL_0000268600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000268600.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16260" checksum="56D68A49860090FC" modified="2015-12-09" version="1">MNDSIIDLISNTKIPPTPDVLDKGYWDTMEGQALKSAKRWARDVLISLTSVILLIIIIISVSCIRAFIKSRNDALLHDPEERWIKSMSLDGRLSLMDSNLYKEQAKLLLVNIDEKEDIQNLFEKIEGNCRNGIKIESVTEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA03</accession>
    <name>A0A0N5BA03_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA03"/>
    <dbReference type="STRING" id="174720.A0A0N5BA03"/>
    <dbReference type="WBParaSite" id="SPAL_0000287200.1">
        <property type="protein sequence ID" value="SPAL_0000287200.1"/>
        <property type="gene ID" value="SPAL_0000287200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="223"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="1">
        <location>
            <begin position="476"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000287200.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="62209" checksum="3A82C655635D706D" modified="2015-12-09" version="1">MAKRELPKEVYCETENSDEEFCFDSLNTDSDIESDNDCSDSSSDIVPVKRRLSQLVMSSDSEVEENDENENSNINEFTTWRNIVGPNVPVHCTEPIDFFRLFFTDTLLETIVLETNKYAKNKIEQQRLSDRSTWNNWVDVTKEELAAFLSVILNMSTIPVPDMKYYWTKKHVGNIPFFRNTFRRGRFLQIFWMLHLNENVSSDTNDVRTRIQKVKNFIDYIDDARTGYIYAMLPYYGSVSTECLIRPDLPVSSRIVLQLYHKLLTANPKAKGYHIFTDRYFTGIPLAQELLKLNCYLTGTLNTNRKYVPAMIKKPALTKNNTVAAYRSGDILLLAWKDKRIITILSSYDTSATTTIERRVKQGNTISIIKPTVITNYNMNKGGIDKADQLASSYCFMRKSCKWWRKIFFWGLEVSAINSYILYKVSTRRENRTPMSHFMFVRKLVEQLVGDFRDGASSKPGRPSTSDKEERLNGKLHILRHCEDVKSKDCIVCSNRKIRGGRRQTNYFCDTCNRKPGLHIGDCFERYHTMEKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA35</accession>
    <name>A0A0N5BA35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA35"/>
    <dbReference type="STRING" id="174720.A0A0N5BA35"/>
    <dbReference type="WBParaSite" id="SPAL_0000290400.1">
        <property type="protein sequence ID" value="SPAL_0000290400.1"/>
        <property type="gene ID" value="SPAL_0000290400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000056">
        <property type="entry name" value="Zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF149">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894035" evidence="13">
        <location>
            <begin position="20"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="140"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000290400.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60062" checksum="E201207B68056BC5" modified="2015-12-09" version="1">MYHCLFFLLSFLTIGILSSQQKYSLHTLKPETQKQVDFLKHLEVNGTSGLLDIKLDFWQAPTAPGRIVQVMIKDVDAESFNKMMDTWEISHNTTISDVEKIIKKRAAEAEERALFEKAFKDSTIRSQSSSRRRVNLSHTQYHSFGSVINYLNTLAISFPDRVQVQPIGTTHEGRQIPLIKIGTEKRTNKPAIWIDGGIHAREWVSPSVVLYFIDQLVNEYEKKPFIRNLVDSIDWYIVPLLNPDGYEHSRSSTDPETRLWRKNKSPQSCITVNSGFFAPPRTQCCQGVDLNRNYDWFFGQYGSSTDPCSEIFQGKHAFSEPETRAVRDFVYKLNGQIKAFLTFHSYSQILMFPFGHQQRTYPSDVDDLRSTANRAADALRRVYGTKYIVGTGADTLYPASGGSEDWAKGKMGIKYAYLFELRPEESVYDGFLLREDQILPTARETWEAVKVIATQTLTTFPAGGFVSQVTQFHKNNVASFARNDDNNFTSTCRDLDALCKYWADNGACPNWPSMRERCPMSCGFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA93</accession>
    <name>A0A0N5BA93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-related protein M-Ras</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA93"/>
    <dbReference type="STRING" id="174720.A0A0N5BA93"/>
    <dbReference type="WBParaSite" id="SPAL_0000296300.1">
        <property type="protein sequence ID" value="SPAL_0000296300.1"/>
        <property type="gene ID" value="SPAL_0000296300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000296300.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23854" checksum="4CD1F84DAD4696E8" modified="2015-12-09" version="1">MQKKPPEDDSKLPLYKLVVIGEGGVGKSSLTIQFFQKHFIDYYDPTIEDQYIQHCEVDGQWVIMDVLDTAGQEEYSAMREQYIRGGKGFLLVYSVTDERSFQQASQLYKQVLRVKDSTEYPVLLVANKIDLVSQRKVTEAQGRKLAEELKLPYIETSAKDPPINVDAAFHELVRIVKSFPSEDDDNLTLGNTGLSGNLSKKKKGKGKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAG9</accession>
    <name>A0A0N5BAG9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ethanolamine kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAG9"/>
    <dbReference type="STRING" id="174720.A0A0N5BAG9"/>
    <dbReference type="WBParaSite" id="SPAL_0000303900.1">
        <property type="protein sequence ID" value="SPAL_0000303900.1"/>
        <property type="gene ID" value="SPAL_0000303900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000303900.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="46187" checksum="5F8198F9B24B724F" modified="2015-12-09" version="1">MEVENNFVNFDGSFNSNNLTVLLEKYLSYKYFVENSNSWRYQKVSGGYSNTLVKATNVLTNKTFLIRLFGSYTSSPEIINKINLINIYLGENKMGPKLYGVFPKGTIEEFLPGRCLTRKELHSYNITEQIGYHMGQIHQLELPFIKSPTFWDDVEEWLNKLQKEEEKILQFYDKSKNKCDDETLSQKIGFKVKRIEESGNSFLQIYIQPALFSSTKTIPETTSVKELREEFELILSKMNKSKCPIVFCHNDLHEGNIMYDEDKNTILPIDYEYSSYNYRGFDFAQTLNHYAWEYAATNKFGYNIFLDEYPNTQQLEIFFKNYKKTNNTTSSVEELINESILFKEIPHFVWCIWGLEKHFSLLCEQKTELSNVSSSFDRLSLYYYYKNNSHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAM4</accession>
    <name>A0A0N5BAM4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAM4"/>
    <dbReference type="STRING" id="174720.A0A0N5BAM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000309100.1">
        <property type="protein sequence ID" value="SPAL_0000309100.1"/>
        <property type="gene ID" value="SPAL_0000309100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="209"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000309100.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32906" checksum="8101D14411B7DF8C" modified="2015-12-09" version="1">MGNDKGFDVKKFAIDLASGGTAAAVSKTAVAPIERVKLLLQVQDASDAIAKDKRYKGIVDVLVRVPKEQGLGALWRGNLANVIRYFPTQALNFAFKDTYKKIFLEGLDKKKDFWKFFAGNLASGGAAGATSLCFVYPLDFARTRLAADIGKGSTREFKGLADCLVKIAKSDGPIGLYRGFFVSVQGIIIYRAAYFGMFDTAKMVLASDDKKLNFFAAWGIAQVVTVGSGILSYPWDTVRRRMMMQSGRKDILYKNTWDCAVKIIKNEGMSAMFKGALSNIFRGTGGALVLAIYDEIQKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAN3</accession>
    <name>A0A0N5BAN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORC3_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAN3"/>
    <dbReference type="STRING" id="174720.A0A0N5BAN3"/>
    <dbReference type="WBParaSite" id="SPAL_0000310000.1">
        <property type="protein sequence ID" value="SPAL_0000310000.1"/>
        <property type="gene ID" value="SPAL_0000310000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000310000.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="65386" checksum="D98582065EC04B99" modified="2015-12-09" version="1">MEKLLEQVQEALESPDGFDNLDEVIEESINTEKGDLISTIVFERGFCDVTRRLNNLSENLITICSSDQSFDIPTFNKLLLTNINNIFSSSCSSLTDMKHLHLTADRTKKLYIVIKQTESFPSTTIDKIITTLYELKLPVILICCVSTNRDSLFLKCSRSNYLLLDIKYASVNSPEVIFDKIWSKIQLNKDIPFIFSNQIIDKARESYFNYSYSIKDIQKYLELSIAFHFNKINNGHVIIDKSNDFSSYKDAFIDTLLLLHDMTKGYYSQKSIWYLYSMIYSNDGNIFDNTDGTEFFRWLSVWNVWGREKFIECLENIEVIINESDCEFLKCLHDDLKMLLERLNTLDKRIEEETKNQQTKFNNIGNVEVKKANNKNKIRINKDERQRILRDKMEYKKNCDLFSKDKKDIFEFLSRFFKMTFSHMYSVKGFSYYFIENISFIQRLIDPPSDYYIDIDLNHLLNNSDQYFNLNTNDKLDVPLSYKLLQSLTNIHTTKPISIEKWKQAFINDCSSDERIDVRFRKTLKVLKQLRVIKDASENNVEKIVCLQHSYTFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAR8</accession>
    <name>A0A0N5BAR8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="4">2.4.1.132</ecNumber>
            <ecNumber evidence="4">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2 4">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3 4">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="4"/>
    <dbReference type="EC" id="2.4.1.257" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAR8"/>
    <dbReference type="STRING" id="174720.A0A0N5BAR8"/>
    <dbReference type="WBParaSite" id="SPAL_0000313300.1">
        <property type="protein sequence ID" value="SPAL_0000313300.1"/>
        <property type="gene ID" value="SPAL_0000313300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF2">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="5">
        <location>
            <begin position="197"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000313300.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48961" checksum="3D06AD8581BBD032" modified="2015-12-09" version="1">MQIVIIHPEQWNGGSDRCTMALIRHFAKAGHHVIWYTTMIDDYWKDEDFSGIEVRNLNIPCHPGDWWSQNAALGLYSIFDNINPDVAIIDHSASCVPIFKWRFPKCKVLFYCHFPQQLVTPSRFFLYRWYSNLVSLLESHLFEAVDVIMLNSNFTASTFHRVMPNISKNKLKVVYPPCDVDAIAVQGKPISRLSRGKNERYIFLSMNRFWPEKRLDIIVEAAYLLKQRGYNPIIKIAGSVMPHIPESKIYYEYLLSMSEKLDVNDIVEYVCSPTESEKFALYRNCDTTLYTPPNEHFGIVPIEALEQRRPVIVCDSGGPSETVLEGITGTKIKEPTGELLAEAMINHMLKESWDHLDKDDMYQYQRERFENEFSAKGYGRRIDETIKEMMIEKELIEIKTQKNDTITYPKSFNNKNLRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAX5</accession>
    <name>A0A0N5BAX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CIA30 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAX5"/>
    <dbReference type="STRING" id="174720.A0A0N5BAX5"/>
    <dbReference type="WBParaSite" id="SPAL_0000318900.1">
        <property type="protein sequence ID" value="SPAL_0000318900.1"/>
        <property type="gene ID" value="SPAL_0000318900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="129"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000318900.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37612" checksum="26D154984F3132F6" modified="2015-12-09" version="1">MLSRSSFLFRRLATKASDNIPTVVPKDESKKQNKIKKKEYKAKVSKATLSLFGNRPAAPTSLAFPNKKGEEGYDPEVPIKELVNDGPKIIKEELSKFIHEASSSASIEKIQLIEDIGILRHGDTKIEYQFKKESDMDKWGTGCDSDWGKGFSTCSFKLTDDNTAVFSGNLVTQIPRDGKVEKAGWASIKTIETNAFMKKKYLSRWSNYSHLIIKCRGDGRSYKVMLHAPGHIDLTWGDTFSYPLHTHGGPYWQIEKIPFSRFFHTVYGRIQDVQEKVYLNKVSSFSIVLMDKIDGPFNLEIDFIGVTHDKSHQEKSAYESYELPIFNSQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBC7</accession>
    <name>A0A0N5BBC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000333500.1">
        <property type="protein sequence ID" value="SPAL_0000333500.1"/>
        <property type="gene ID" value="SPAL_0000333500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000333500.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11949" checksum="C88F010D8CE6A0CA" modified="2015-12-09" version="1">MFVTVDGELLMKYLNIIVFLTLRQDSWYSSSSKQEPTEEFEAVEEEVLIEEFQYFEGDGDVESMMKDAVFVAVEEGVEVAVDPIDIDEVLLIDIISVASLVQIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDD7</accession>
    <name>A0A0N5BDD7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDD7"/>
    <dbReference type="STRING" id="174720.A0A0N5BDD7"/>
    <dbReference type="WBParaSite" id="SPAL_0000402300.1">
        <property type="protein sequence ID" value="SPAL_0000402300.1"/>
        <property type="gene ID" value="SPAL_0000402300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000402300.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27008" checksum="3A96190293A33A5D" modified="2015-12-09" version="1">MDSDGFVIVAKRRSCKPKLKIDEMNFIYPCTIEISFKRTNENVCRAINQLTKDKYINMFLTLLEKILNGDRISKIKCYGIGHFGELDGSGTYQLALLILIQKHYNISVTIQEPILNDVEINYINNYPFFEYISGDDLTSIEISESQNDYVLFFIPHGEDEMYEGILKTHNNEKQRQKMIILGNVLDDISITYKNISNFKYWKEYYDVCKKHILPTYSKCMGAFNNTCLMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDV8</accession>
    <name>A0A0N5BDV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000418600.1">
        <property type="protein sequence ID" value="SPAL_0000418600.1"/>
        <property type="gene ID" value="SPAL_0000418600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35017">
        <property type="entry name" value="PROTEIN CBG16223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35017:SF1">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000418600.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14805" checksum="28B4713AF373F0C8" modified="2015-12-09" version="1">MPCCLETIGKKSCEEMLRTKPYAFEEKCENDPDFAIIQCCHTCQTNVQEFGLRVFNKGKKSKECFDRHAKKFCLQFLYRLGAWSTMKSNEMSCEGDSLPLAFRICRKTCGFCDRRLYKNNNISNHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE72</accession>
    <name>A0A0N5BE72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imm40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE72"/>
    <dbReference type="WBParaSite" id="SPAL_0000429700.1">
        <property type="protein sequence ID" value="SPAL_0000429700.1"/>
        <property type="gene ID" value="SPAL_0000429700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000429700.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="11019" checksum="016837299EDA8761" modified="2015-12-09" version="1">MQFNIIEYPNNGVITKNYDNWEELMVFLRGEMEEDSPTFGYYWIDIDGNLNYLSHNNDYEDMFRSCKKFDQSIINIVHTNFLDYISNNAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEE8</accession>
    <name>A0A0N5BEE8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEE8"/>
    <dbReference type="STRING" id="174720.A0A0N5BEE8"/>
    <dbReference type="WBParaSite" id="SPAL_0000437400.1">
        <property type="protein sequence ID" value="SPAL_0000437400.1"/>
        <property type="gene ID" value="SPAL_0000437400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25143">
        <property type="entry name" value="Zn_ribbon_IFT122_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="8">
        <location>
            <begin position="318"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="11">
        <location>
            <begin position="582"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000437400.1"/>
        </source>
    </evidence>
    <sequence length="1171" mass="134698" checksum="392CFDD92558DBCE" modified="2015-12-09" version="1">MRNLFYLLFNSFYLFYRSTIYDIAFKPDGTELIAAADCKVLVYDASDGTLLKSLKGHKDIVYAVTYSHTGELIASGSADKSVIIWNDIHEGTLKYSHNESIQCIAFNPFSNTLISCSISDFGLWQQEDKNVSKYKVFSRCCACAWNSTGEIFAIGMFDGTVSLRSETDGELLHTIVRPGGEPVWALTFASPRLDYTQPSKGKINYAPIYYPGEMLVVTDWARKISFYNIEGQNVPPNEKELEFDVFSIAYMCNGNFLIIGGMDRNILLYTREGTCLGCVAIMDSWVTVIKVRPKTNTIVVGCVDGGIACYQLMFSTVHGLHKDKYAYRLNMTDVIIQHLSKQINTRINCGDLVKKVAVYNQKLAIQLTDKVNIYNQVTGDKENEPLDYRLVERINQNFECSLLVICAQHLILCQEKRLQCYDFKGLRQREWIMDSLIRYIKVIGGPPGREAILLGLRNGLICKIFVDNPFPLIIYQLKNAVRCLDISQEKKKLATVDENGVCTTVSLQTKEVLFSEPNSSSVAFNTENENLLCYSGNNILNVKAYDFTPNSQKMQGFVVGFSGKKVFSLHLYQMSTIEVPLTNHLYQYLEKHMYKEAYDIAILGVTENDWAILANDALENLEFDIAKKAFCKIKDCRSLMLIYEVEDMLNKGHSKPELLGYILAHQGRFREAATVYQQNNLEMNALDMFSELRMFDEAQEYMLKASVDTQKAIIRKKAEWAKLSNNMAIAAQMLVDSEDYDKAIQIMIDNDWLDMILQTLRKIDKGNTELLKTIGYYLIKREEFSVATSIFTSINDVRSLLNMHIVARQWDDAFAICQHNPQYTDIVYLPYARWLAEEGRFDEAQEAYKKSGNISEAFSVLNTLAINALKEKRYMDASYYHWKLATTYLVKSQTSPKYIEKFYEYLRNADIYYAYDTVYKCTTEPFTSVRKENLFNCLRYLILNYEDTPYISRFAILFSFTELCKEFKAYKTTRLALDQLTQLNYPLHYESQIHYSFIDIRAAPFTDNEDLLPLCFKCGLHNPLLGKKSCAQCKTEFLYSFFSFDILPLVEIKISDDITDEEAVDLISKEAGDSGVNTSSIVHSQEKTKDIILTREQLLILDKTNCFIQKWPKPLRYRYFVNVLQEINITQCDECFKFFLLDDYEEAILENECCPFCRKKIAIFNDNDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGG5</accession>
    <name>A0A0N5BGG5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGG5"/>
    <dbReference type="WBParaSite" id="SPAL_0000507100.1">
        <property type="protein sequence ID" value="SPAL_0000507100.1"/>
        <property type="gene ID" value="SPAL_0000507100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF16">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000507100.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30905" checksum="0B23ABF379CDDDB1" modified="2015-12-09" version="1">MCFILMVFFPPVTGYMQVFMEPSYNWTVFYALMYYFTYCQFFLCAYIAFIRFILIYFPLKGTDILKKTFWLFVVLLLITSYAPTWHLWFCKTYFGPIDKRYTKGYLIFSISYKKLEWMNVSNSKNSIIYYFIFLTISFILNLTSLIKLIFKNLLSSVGKKKSVKGNVSMLIYSLIVMVVQLLFISLNCVWYFTDPNTPDMSIYHICQKLRVYVYHLMCLLQPYALILLSKSTRNILKNIIINSFKTRHQSGSTKIQINRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH27</accession>
    <name>A0A0N5BH27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH27"/>
    <dbReference type="STRING" id="174720.A0A0N5BH27"/>
    <dbReference type="WBParaSite" id="SPAL_0000527200.1">
        <property type="protein sequence ID" value="SPAL_0000527200.1"/>
        <property type="gene ID" value="SPAL_0000527200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894510" evidence="2">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000527200.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32656" checksum="91C068E748BD5322" modified="2015-12-09" version="1">MRASLICFLLFIIYGLSNGSVLGDEIKRSKRQSPLSRAWEEALPGVQPFWEKYSNGPYGIVIRGWQFSRCASEQWTNYVVNVSNIVIWPDYPRFPGPIFFNVTMDVNEDLPVGKIEMDLEVRHAVTNKQGSKGWQVIPCQGWNMIDGCDGVGSCRYCDMLDKCQETVNSAYKYVHDKKATDFLKNNKLCPPPKGHWTMTFSKVFSVDDLPKSFFGPLQSNEYWLTFSFTDGKDKKLGCARLWVDVCKYHLQDKQQKCLRDPNAFKNFINEISSQAEQLRRRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHJ5</accession>
    <name>A0A0N5BHJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000543400.1">
        <property type="protein sequence ID" value="SPAL_0000543400.1"/>
        <property type="gene ID" value="SPAL_0000543400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894618" evidence="1">
        <location>
            <begin position="21"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="3">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="352"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="448"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="636"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="806"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000543400.1"/>
        </source>
    </evidence>
    <sequence length="935" mass="107597" checksum="C5BBA14BAA1FE3A3" modified="2015-12-09" version="1">MLKLLWILAVYSIYICSCHGSDDYKKQFKYFYNDYNCSNYKFHESFPRKHNVKSNTEIIAIKCPTEHIEKEKCSNLKGYTYIIIYFKSSSDVKESLIFGSKEGRRYDWRIYDIKKNEKKKIINCIDVMRGDPRNSLTVKWEHSISRNSGSEIDIKRKEDFNIMSHTYQDSILRMNVKEKTFVFGAGLSYREFNSEHSRIYKGDVLFTFNANEINSEDVEFQEPIGITQVYHPPPFIDIQNDLTIKVNAKNKEWCLVEPHKFPFTLKIKLAFNGTTSQPNFFDYENITVSYLKYSKDNKLREIKKDILKPNSPNTRNILLNESAIIKLNYFCDNCIEGGIDIVQNMIIGKKFDFENKVLPSVEYLYDKLNFEANCSMNLNIFTQLKAVSFDDELIEVQALHGANDEAKGNFSLSNGVVKFKNTNPNGIIKCTYIYPAGEFHTSQTYKSFKDEEMPSITYVYDKLFFKPNCSMSQGKSVTLKTVLFNNEKIEAAKLQGTGGNQKGNFKKDNKFVVFTGTNPNGALSCTYQLPYGEISKYQKYKSFKDQNIPPFTYPRGGLRLTPNCPMDQGDSVNLKTVSFDEERVEVSDLNSRSDKRKGNFKSDGKFVNFLGTNPKGKLSCVFKLSYGEVSTNQSYGYFSNINHPIIRYASDQLVIRPNCSMEPEKNVNLETILFNDESVEADYLQNTDNNPKGKCTCVYKLQFGEIKTFQEYQSIEDTTLPDVKYAYDQLNFNPNCSREENTYTQLKTIKLNDKTIEVEGLNDAELIQMGNLKPTKNLLLYTVQNPEGKFSCIYKVPIGEIEKSQNYKPISNETLPVVEYSYNDLGYNANCSRYLNSFTHLRGIQFKDDKTTVVSLQRSRVGALGRLKLEKDFVINTEKNPNGTLRCLYDVPIGEVLVIKEFRTFKTGDEENSSKKMGYVASIIFGYMIVISMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHN1</accession>
    <name>A0A0N5BHN1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHN1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHN1"/>
    <dbReference type="WBParaSite" id="SPAL_0000546800.1">
        <property type="protein sequence ID" value="SPAL_0000546800.1"/>
        <property type="gene ID" value="SPAL_0000546800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000546800.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24495" checksum="4781436EBBB3BBC2" modified="2015-12-09" version="1">MAIPIGEDPLNQTPIIGYDEDFEEEILPVYRPESLSSICKMTKFSPREIRVIYRAFKQGCPTGVVNLKEFQNIYAQFFPHSNSQKYAEFVFKTFDKDKDECLSFEDFVKGLSMISRGSPEEKLAWIFDLYDIHKKNCISPSDMLTVVHSIYELLGNGYFPPVNKTSVIDQVIDAFNKIKEGNNQTITKDQFISKCLKNPEILKTLDLFTTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI59</accession>
    <name>A0A0N5BI59_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI59"/>
    <dbReference type="STRING" id="174720.A0A0N5BI59"/>
    <dbReference type="WBParaSite" id="SPAL_0000564300.1">
        <property type="protein sequence ID" value="SPAL_0000564300.1"/>
        <property type="gene ID" value="SPAL_0000564300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000564300.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16746" checksum="7C0E841B6C5AC264" modified="2015-12-09" version="1">MASFYKHPERARRKETLHNIPFKKTWKNLLLIQVGAVGAGKAKTFENDLYDYVNISIVSNSFLREQIRRMMSVITAYGYGRMDKSTIKYLLERPKPSNFFDMDIPVAPPQGLFLTDVVYDPSLYMRPIPYFNNELNSAELDDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJL2</accession>
    <name>A0A0N5BJL2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA 3'-5' helicase Q1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="STRING" id="174720.A0A0N5BJL2"/>
    <dbReference type="WBParaSite" id="SPAL_0000613700.1">
        <property type="protein sequence ID" value="SPAL_0000613700.1"/>
        <property type="gene ID" value="SPAL_0000613700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000613700.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25731" checksum="2FBC6EB180BB333D" modified="2015-12-09" version="1">XSATMPEEGFNGIQTLLNKKGKVVLRGSAFRSNIVIVNINSPDVFELTNILDSVKKIMDLKKYFYPNEKIKGICVASTREAAKTATHLFNSYGILAIEYHSKIKEFTRSEVFEKWQNEDIELLVTCDSNLTGLDPKRCDYIIHYSLPMYISTYIQEIGRLSRDGRIAFALLYTTSEVNKVYKRRSAGKKQDIDEANKRLSDIASQSSESSVQRQRIQNLYLKGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJZ6</accession>
    <name>A0A0N5BJZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000626200.1">
        <property type="protein sequence ID" value="SPAL_0000626200.1"/>
        <property type="gene ID" value="SPAL_0000626200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000626200.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42206" checksum="D3D46C8A8F2B826B" modified="2015-12-09" version="1">MYGGKIDSRRKTKSSDYCHNISSPVDRTVDSCHSCLTMRKFPHKLYALWITATHPRRICSLYSCYVSNSTLIMLVDYLFNFMYGQVLPDQFSQAIIKFLSPTMDEYPLFILIYDAESALTSNTLSEFFSSYRIGFHSNLQPSNTQKITSIKYRLKSNGRNEGHINSLHKTFQKADLLNILPSQRLQWTTIALNTPLSRTKNSNGGNQFLLPAEKYYLDWSVILLKLPTFEECAPSSLHTSYTLSNSILLSNNKATVKVPESSLTTPSFFPPECQHALDESLDKSHVEIYLNSLQPSINVQKVVINVDCDYASDTASYDWYEREFDKKGKYPHSNLWKQIADLMPSSYWAYHCIRDVFPLHVIIRKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKE4</accession>
    <name>A0A0N5BKE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKE4"/>
    <dbReference type="STRING" id="174720.A0A0N5BKE4"/>
    <dbReference type="WBParaSite" id="SPAL_0000640200.1">
        <property type="protein sequence ID" value="SPAL_0000640200.1"/>
        <property type="gene ID" value="SPAL_0000640200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000355">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000941">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF405">
        <property type="entry name" value="PROTEIN CBG12249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000640200.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59068" checksum="87DC716DED94235E" modified="2015-12-09" version="1">MESDGIIRDNSLFTAKTMRLYIALLLMMGLFCSTVLRINLGMSMVCMVNSTAFVNETVEIQKQSFDVIDSVSDLKKYVCLKKTVINEKIDMGYHGTFLWSPSMQSALFSANFYGGIITIIFSGYLADIFGAKSLLLMAIIDCSIISFLSPTIASISYLLFFIGRMIMGLGEGFVIPTMSSMAARWFPSHERSTVAAIYTSGNQLAGILGLLISSKLCSINFLGGWPLIFYFFGLLGIIWSVLWLVFASDEPQTNKWASENEKKYLKEITQGQIKKIAGSAKFHKPSIPWKRLILCGPLWANLLAQFSFNFGISFIQSFLPTYLKDILLLPLDQNGLFVMIPYVAQLIPKNIFAIISDGLKKSGILTPTMACKIFQCFGNFGTAIAFIGLALYVDCTTKVLFALLLVFYGVAFSCGVSGFYTSIISIAPPYTGLMTSICMIFGMIGNATSPNVFSILNQNGTPEEWSRMFMAVAIINIVAGVVFLLFGSADVQDWAESRRSSRVEDIQQNAIKLRVSTKRKRTVSDVTVDEITMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKF3</accession>
    <name>A0A0N5BKF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RalBP1-associated Eps domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BKF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000641000.1">
        <property type="protein sequence ID" value="SPAL_0000641000.1"/>
        <property type="gene ID" value="SPAL_0000641000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="170"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000641000.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="65144" checksum="05959220AC76BEE8" modified="2015-12-09" version="1">MSNALKEKLVLESKTNLCTNIDWNQKTDKEIVDCKNPTLSNEDDKNKTFLFSETKSNEMKGSSSIDSTNDNSNSIDDFSIDSENKDFGFRKESTNINTSESEDDNYYDSSSFSSSDATESETERKNLLCDEDDLEHENGDAVSNVPSPPPSISTPRPSPSPTIFIMTKEQKAYYEKCFLHLQTACNGPNYRASLDGAVEGNSEIVMDFFEKSRLPPEELSRIWLLSDVNEDGFLNLEEFSMAMHLVVLRIKGGIKIPQSLPDEVRPKEEEPRENEFNESLTSSTTCSSNMDDESKKSWRQFDKNSNNKEGNINFSCEINGKENNLKLDNDGTHNSNKIIDDSSMMSNFSKTPPLIVDQTPRAKKLSSSPTSVTKSSTPVLISPIIDNDLIDHPLPPPRPLNLKPGKGHGRSASLDTNALNAIINENASMDLMIQEDVLSSLKTKDICKSLLTDKEKLLLKDNFNGENICKCFKDASAQTDTLTNTDFDRLAKQLDNLLKSTPSGDNVFSQKLDEPFLDESNLTFEERCHLLRKFNWQLEKERSTLIQIRLQLQLRLEEIEKKYSDEKQINSRKPTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKH1</accession>
    <name>A0A0N5BKH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3707 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKH1"/>
    <dbReference type="WBParaSite" id="SPAL_0000642800.1">
        <property type="protein sequence ID" value="SPAL_0000642800.1"/>
        <property type="gene ID" value="SPAL_0000642800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894513" evidence="1">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000642800.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22802" checksum="64CC710BB891C840" modified="2015-12-09" version="1">MMLIIVFLVFIKLLECQRVDNYCKLYQDFYYKPNTCNYQVIRTNISQIYCPETFCLYASGYIQVSRFKIFEGKFYGCPSFLRYIGGVLNIDSEIFDSSISKCQNMNSCMEVNYKLPTTPGETIIDMTLCCNNENEQKFHDPPPVVIEPCNSNCSNIRNEQIILPVVDCLPVVKNNINNLKISNIIFILSLILMFLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL31</accession>
    <name>A0A0N5BL31_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL31"/>
    <dbReference type="STRING" id="174720.A0A0N5BL31"/>
    <dbReference type="WBParaSite" id="SPAL_0000663300.1">
        <property type="protein sequence ID" value="SPAL_0000663300.1"/>
        <property type="gene ID" value="SPAL_0000663300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000663300.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18899" checksum="D093F83C77BB7AE0" modified="2015-12-09" version="1">MAFDFKKAFDSINHSWLLYSLAINDFDEELVKRIEALYRSPKATFSTGINNSYTTIEVKSGIRQSDTVSPKLFILLLKIILKNAQHDLDDCFKNEESNLVKVMIDGTPTVSFKLEFAEDIVIYTYDQKLTEKIAHVIKYHDRKTGLELSKDKTKMMATQYKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLL4</accession>
    <name>A0A0N5BLL4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BLL4"/>
    <dbReference type="WBParaSite" id="SPAL_0000681000.1">
        <property type="protein sequence ID" value="SPAL_0000681000.1"/>
        <property type="gene ID" value="SPAL_0000681000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF6">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894692" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="324"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="435"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="539"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000681000.1"/>
        </source>
    </evidence>
    <sequence length="1411" mass="154844" checksum="F78FBE745C532098" modified="2015-12-09" version="1">MIPLFGITISFLFYTSALSLQCNPTQSIKKVNPDDPFSYLYCNLEGLFTVKMCSPGNIFNTEKAECEVMGKNDDPFLRPQNQAPDDICMGGVPLTRLSAPVVCNPSISSCPDGYVCNIYSKTGTAYCCKNPNYEVEENRDILCPGNQVTYYDDNALPKTCLLNKKGSCPSGFGCTLIADTTTRCCGQSFGCPTNSAGLVNSMTGGFTGCDINDKKSWPHGFVCKKSAKFNNDILCSDTSTIANDICNGGIPLRRKKKCHDKYPCPIGFSCENGICCPTFPECPVGEPLNKGTMKCSDSAPCPEGFDCVSVTNTTYCCPSSVFVCNLPKENGFECSNNPPITLRYYFDRSTGICKPFKFTQCGGNSNNFINKETCENFCQYTQCNKGGIPHRQYPSNTYCSTLINQNINTCPYGYACTNSILNNNAICCPIKENICNEEVTAGTPCYNLQVSILRFYYDSEDGKCKPFQFFGCNGNNNRFLTINECEDTCVLTFANVCNGMAPLIAPNHELATCSDDFPCPDGYTCNSDGNCCPEQQLACQSHVSLGSTCSKFKAEKAWYWDEEHAECKQFLFNGCGGSPNRFFSKSACLEACTKPVGECPSGMNPFRSEGMIQECTLNVASSCPNGYSCVTSTTDVSICCQSVAKCPSPRKPYIIPGSDSFVACTPDSKTCPKNYECLESDKVNGFYLCCSSNNSKRISNSNNGLSIKTSPLRQKISEHLTCPDNLESNGIKCKINGKNECESGYTCMGNGLNGVCCKGIPTCKRNLQAVFLAPKQVQLCGKGLFGCPRGSACAISSVKGINICCKTNTFFGNKGSLVPKCKGNKIPFYELGSRTPKLCEIGSKNTCPKDYICQETSNDEYHCCPAPDQCPNKGVAYIINGKALACNIEVNNCPSGYKCEGEPETAICCKRPLDVTSCPDNRNAYTMAGRPLVCPKGSKTCPNGYSCLSSINDDKIHICCEDKMSNQLNEHPKCFQGEPYRDIFSQQTFKECTREFNTCPVGYDCDESTVRGKWICCSTNLINKQYEGYCPMGQIPYVGMNSPEPPSCHMTLTPCPTSGAYTCVYSAQKQNSYCCAPLEAAVFMAPQKPTPIPDNGEINFNGNLDNEIGCPTGTRPLLEFGMPKRCSVLDVCPNDYNCKQNKHDASVWQCCSNVIIIDANQLTNTNPIDYNNNYQFPGNNFNGNEQGIFPSNNMNFMNPIKGGQLVLRAGMSSLDVEELDASKGCPNGFSAINNKCKKMYYLGQRGCQVDEQCSLTTQYAYCNKEYCACPHDKLIHNAKCVDTCPLGFLNIAGRCHDITTVMLMDSVDERKNGTIGGFCLSTVVAEEQCLVKNSFCNEKSITCQCKPGFELEVNFDDINDKGSCTEFEESKFTQERLNDYLKPHNQEPELFYVMEMRDDEEVVTSVAPQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPI6</accession>
    <name>A0A0N5BPI6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPI6"/>
    <dbReference type="STRING" id="174720.A0A0N5BPI6"/>
    <dbReference type="WBParaSite" id="SPAL_0000781000.1">
        <property type="protein sequence ID" value="SPAL_0000781000.1"/>
        <property type="gene ID" value="SPAL_0000781000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000781000.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28971" checksum="22C07D1D69CF632E" modified="2015-12-09" version="1">MISKSKNLLLFDVDGTLTESRKKILDENKKFWIELSKTQTLGIVGGSDFGKICEQMDLSEEELCSTFSYVFAENGLDGRIDGKEIPKQSIVKFLGDVKYQNLINYIFKLYSEIDIPKKRGNFVELRNGMVNISPIGRSCTQEERDEFYLYDQEHNVRRGMVEKLKEKFSEYELDFVIGGQISIDIFPVGWDKRYCLKYVDGQFENIHFFGDKTMPGGNDYSIFNDNRTIGHTVTTPEDTINQVKDIISKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPP5</accession>
    <name>A0A0N5BPP5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPP5"/>
    <dbReference type="STRING" id="174720.A0A0N5BPP5"/>
    <dbReference type="WBParaSite" id="SPAL_0000787000.1">
        <property type="protein sequence ID" value="SPAL_0000787000.1"/>
        <property type="gene ID" value="SPAL_0000787000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000787000.1"/>
        </source>
    </evidence>
    <sequence length="1158" mass="132600" checksum="A71122ED361BC32E" modified="2015-12-09" version="1">MKQSSLMTFFSKTPKGEDGDSMVTGSVAEKDDNPKTPTRSKKPTFGSDSVTNFDDSMSNLKSVKRSHGDVIAEPDDSPLSNLKSTQKRRRVYIDSDSDVDMMDTENDSGKNKKFVDAYTPKLSRALSKTTINSTKKTDISSLNKEYDRLAKLKVPDPSEIDLIRVAETKEDNPNLDDILENGPVNPEDNFVHLTFDFLKPENIRDINGRRPDDPDYDKKTLFVPEKFIQEQTPAHRQWWRLKVHNFDVVLFFKIGKFYEMFHMDSVIGHEILGLTYMRGKFAHSGFPEASFGRYADQLISLGYKVARVEQTETPQMLEERCKKTKVKDKVVARELCQIGSIATRIYTPIDEFTRKGNYEEREDEKYLMAMYFTPKERDTFNFGVTFINTTVGTFYLSQFTDDNVNSGLRTLLSHFQPTQLLIEKRCPRKIINLLSSVLPYTQFEYLIPKEEFYDPEKTFYEMTDDKYFGANTDEWPELFRRFIEESPSAIPKVKKSYYECIKSFGGILFYLQRFLIDVDMISMRNFTFVNPQDSDQIIDSIKSTSNHWNKRCLVLDGDAIYQLSLLPPLRPIGVKNVHERRERKINLFSTINNCSTTFGKRLLKHWIRTPICDPLELGKRQSSVRLFCEPRFSDLARSISKKLKGLPDLEKFLQKNHANASKYRKESHPDGRAVMFESKKYDKRKISDFVGMIRGFGVIVDVVDILKKSGILDEEDSAIKDMFGGDFDFTHEEVNSFTRSFDQDEALKEGMIIPNPGVDDDFDNAVEEVDKYCKELNQYLERLMVQMRCPKLRYIKTGKNRYHIEVPADSVNRVPSGFNFHSKTKAFHRFTSEESLDLVEKLTAAEVKKETIRRDLSRKIYYYFDQKREQWDRGVKKISYLDCLLSLSIYSLTSGLEMTLPEFDYDSSAPYIDISEGYHPLLAMNMDRAIKFGNSRPTVYIPNDTVLGKTKGVAMLMTGPNMGGKSTLMRQVATLVILAQLGSMVPAKSMKLTPVDRIFTRMGASDRIFGNESTYAVELNETNRILRGATKHSLVIIDELGRGTGTMDGLSIAGATLEYCASYIGCRTIFATHFQSLCTAFKDHKDVFLAHMACHNDSETDDPTDANITFLYTLTDGQCTQSYGFYVAKLAGLPTRMIKNAYAASLRLAHTDADMICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRG5</accession>
    <name>A0A0N5BRG5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRG5"/>
    <dbReference type="STRING" id="174720.A0A0N5BRG5"/>
    <dbReference type="WBParaSite" id="SPAL_0000846400.1">
        <property type="protein sequence ID" value="SPAL_0000846400.1"/>
        <property type="gene ID" value="SPAL_0000846400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000846400.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46504" checksum="BD6C228453C78A29" modified="2015-12-09" version="1">MPIILTRPPSQPSRTSEPRKFQKTFRKNRLWRILVLTSFQLLTAIQAEMKTKEKSLAMVKKVLNQSKMNHPLVAAIIENVGTCSDLHFKAPSFDESLYSLLHSKKRSGQDATLRKATDFILQTAAILFNFYESDKGPEYKKLGIAGVANLKHAADIITYLRRARIRMLAHASMEQINSFINPTKGRPLHTIKSNEYRPTGRQYAYSEGRTGHVLRNNFSKISIQQYVENWHNGADIIIKQPLAKARVKNNIITSMEEEKAIDKEVSNMLSNGSTIAVDNPVWILPIFAISKKGRDDKWRVIIDIVDLTSAYHSIAIMPKYIPYTAIQWKAKTYGFRVLPFGCPISPSIFYRCTDQICRFLRSRNIKLNCFYDEYLLINENSNQLLEEVDLTIRTFTSLRFAVNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRT3</accession>
    <name>A0A0N5BRT3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRT3"/>
    <dbReference type="STRING" id="174720.A0A0N5BRT3"/>
    <dbReference type="WBParaSite" id="SPAL_0000857800.1">
        <property type="protein sequence ID" value="SPAL_0000857800.1"/>
        <property type="gene ID" value="SPAL_0000857800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000857800.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38454" checksum="C71179DE9448503A" modified="2015-12-09" version="1">MASSVPFKKPKDAGVLLKQFSAYSMDEKVNNFKRYLQDYYKYDSKEIPLELSTEQMEMAYTKIGFERDKAYMRIVLMGQLIDQDTLKELLPINRNNIEDPFNEVIYQKIISLKKAIEALESTTSPEYPDLCKYIVNRLKEQLYSNCISDFNVYQEITESITQYIAQNGIESHKISSLPKKSKDEIYLKMNEKFHSVVRCNRFDYVEKPEDYNRMIESQKINISSDEEISLEDEEEDSSICDGEEEYEEIYIDENSQDDDNIASVSNDKDSGEFKDNKSTEDCESPSKTSSTSKRTAEDGSDIEIVGYGKCAKFSNESNSAHDEIECIIISDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS48</accession>
    <name>A0A0N5BS48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS48"/>
    <dbReference type="WBParaSite" id="SPAL_0000869400.1">
        <property type="protein sequence ID" value="SPAL_0000869400.1"/>
        <property type="gene ID" value="SPAL_0000869400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000869400.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18886" checksum="27803E7B619129C5" modified="2015-12-09" version="1">MRNYQVLKDGFVTEINQYRRLHNALPLEESQSLNKFATARAWVSCLNNPSGLKYSPKIGHLGLRHYIVHGNIIVKNMYEKFMLGYNWNAKRHVGRYDKYAQLIWKDTKKVGVGVCLKYGDIHVVIAFYPRGCIGDFSANVQPIGPKHIHMFGVFGRNSETNRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTZ6</accession>
    <name>A0A0N5BTZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTZ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BTZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000932100.1">
        <property type="protein sequence ID" value="SPAL_0000932100.1"/>
        <property type="gene ID" value="SPAL_0000932100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894946" evidence="3">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000932100.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22734" checksum="32394CAE646E9678" modified="2015-12-09" version="1">MTNLLLVVLIIVFVSISSVQCRDIRAISIKDEPPYPVSRGTPLSKNLNLICVNGHKVGAKCICKAGFSGEFCQNKMYCQDFNRTSDGSCEACMENYEGNFCDTPICKHGTVDKSVQKCVCTEPYSGEFCTKFVKADVLLFHNLKMRNFGPLGFLFIIPMALVYYCCERESKKRKVQRYAKILEGEEFEVSHEAVKNILHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUB5</accession>
    <name>A0A0N5BUB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BUB5"/>
    <dbReference type="WBParaSite" id="SPAL_0000943600.1">
        <property type="protein sequence ID" value="SPAL_0000943600.1"/>
        <property type="gene ID" value="SPAL_0000943600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="9">
        <location>
            <begin position="775"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1441"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000943600.1"/>
        </source>
    </evidence>
    <sequence length="1535" mass="180262" checksum="92518923F5D15830" modified="2015-12-09" version="1">MSHIDKQNQLISLLKELHKNNENYIFEDNFLLYLKPSKHDIIKDRLPFNCYDNENDVTNLPPHIYDVARTALIRSLVSKKDVSIILNGGSQSGKTYNIYKCLKYFSKFSLNKNKNFNCDVINSIHLLIRNLCCIDSITEIPLLYKVNISINGISGIELRNVLFNGYNKLICFNENVKNFNIFYTMFYGMDENDKERFNLKNKEFFLLNNTLLDKKEKQLCRNEYNNLKNCMLNILGFTEEHFETFQSIICGILNIGNISFYTDTNSDQKIVKLCQKPEILSITKLLKLEISEIYNIFNYKKYGNNIEKALDLRDGLIEILYKKLIDWVLMRIENIYNDKGNSSIYMFDYKGYTSSGYNEYDEFCTNITNELYMNIFLSKYMEFYLNNNGMVEDDISLTKKTNENCLNILVNDKKNLLTILNDECIFPLTSNSALIQKFDLNFIDQNCYLNSRSIKTFEFGIKHFFGVQYYNVSDFLLQNKRNIYNWIDDIFLKSEDSTIVSMFHVQPDIEERVNQKFVASEIVESLKKNIISKLSKTENIFVFCLKPSLKRNSKEFDCNFITKQLKSQGLLDLLKIKSNNFNHRYHITQFLNEFKILLPNNLMKEQNDNQITNNILINQGSKFTNDYLIVNNIVYLNENLAKQLEWRKYKHFMRCIIKIQALYRGYKARKSFQSKKSATIKIQSYFRGWNARKFIVKKKYEIKEKLMKENDNCKFVAKSKDICIPIGKTTDTYELKLEIEEEYEKIPIKQDILSIIPISIEEFTKKYIKYHKIGVKREVIFAPFLEKENEIDYRESLRVFKIILEFMSSEKISNFFVKNIIETGISNIKLRDEIYIQILNQTYNNSSKKEVDRILILLLVTLNSFLPSPFLFPVLLNYFDSQKSTLQILFTQIFYRHLSISQLQTSRKYSAITTYEMITFSKKQPLCIRINVSGVCMVSIQIDSLSTIKEIVKNCLGKMSIGNVNGWNVDGEFIKNEMIIKLEEKDYIFDIIYMVENDMINIIKNEKFTFPSTMKRPKHNEESSDTFEASQTNGKNIMIDEMGNNVGKRSSFSNDNLLSPRTLRRVYIVEEKNVPERVKIFDDNNNNDISKLDENGNNMECVNMSAKSLEKEIYSPIRYTPILEVDDDVEDLIDNIFNNAISEGNNNMLRSSIEKTLVKNIQGGIENIKEVPTNAFNKQNFYDYHDYETSSSIYNTLSTSKVTPNIDRHSKVEESSMALSMMELQTLVKLGEKKSYISDNIQSDHSKNEGAILVSPKLYNLILRKELFFPCEITDKYEVDLIYLQIINDCKENNPYRIEKKERNAINNILRYNKMSLNDIDMPEKIPFKVKDDIVNCARRWPLYFSRVYYVEKITEKGNEKYQLHVSENGIYIVEIIPNFTHSPYKIIDTISYDEIADTYFEDENIFSIYLYNNINFKFLTSNESEEIRKLVHIYLNPILEKPVYVHAIAPFLSNNNELLSFDKGSQIQIINDNYYHKSTIPNHGNRWLFGKCNNSVGWFSTEYVSMTCTEDDSYVTPYFDHQQVSFPLKSYKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUE0</accession>
    <name>A0A0N5BUE0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUE0"/>
    <dbReference type="WBParaSite" id="SPAL_0000946100.1">
        <property type="protein sequence ID" value="SPAL_0000946100.1"/>
        <property type="gene ID" value="SPAL_0000946100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000946100.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="60398" checksum="8D3B217CD3DB0DCE" modified="2015-12-09" version="1">MDLKKYYLINHIKLKIHQSKVVKKLINFFQSNPLITYIFVYFLIAYSKSLLDDFVAPQHVAILSTTHYEDDKTVTILLNAHRHFDTLHPYVCISRNKTSTKLSYALTVHAFHPINVCKWTAFISKCDVIDNMEKLELSMHSDIINNAVSLPIRKAYSKKGKVMSCFSPLFYNERWQLMIATLEIFKELGVDKQIYYIQSMVHDVFQALDAYKKKGYVEIEPWSKINLGKEFELGYDVNHELDWRNQASAHTDCFLKYKNAADFIMIGDIDDVLFPRMGRSYFEEFTYFSKIYPSAAGFIYDRYNTEVSANKNVENFRMDNLLSSSIVLNEWEDGKYVVNTSRIDTAWLHWPGRIKYGYHMQTIPNEKNVMLHFRRWKIKELINGTETLIEKMSKSKSSLFNMQIYDIIEKRMVDKIERNWKKNYQSVPELRYLPKTMHYYTTIAKCYNKIFYSIDKTPTHCPGPIRCDIPEIPGLKCMVAHSKHFKTHFTKNNIILHYLDGILLQKTENGCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUG7</accession>
    <name>A0A0N5BUG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUG7"/>
    <dbReference type="WBParaSite" id="SPAL_0000948700.1">
        <property type="protein sequence ID" value="SPAL_0000948700.1"/>
        <property type="gene ID" value="SPAL_0000948700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000948700.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13708" checksum="9409DD5CFBE5EC4B" modified="2015-12-09" version="1">MCNDVVMNKPSSQVIAFLPQGNNHDNASTFKLNLFDKNTKLYSGHRLHFVNDRDFSNKTWDIERSIGYAINYEPKCKVPNLNATLSLVINDVVQECDTKIDQKFGRKETYTFASTETINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUQ5</accession>
    <name>A0A0N5BUQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterogeneous nuclear ribonucleoprotein M</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000957500.1">
        <property type="protein sequence ID" value="SPAL_0000957500.1"/>
        <property type="gene ID" value="SPAL_0000957500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000957500.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17194" checksum="D91E3D0348B88667" modified="2015-12-09" version="1">MCTLYFALNDPTMSNVLLRNLGAMEALEIEFDAYEAKRNMDILNRLNMKLHKFMMICKHLHILDQCTRSPVVDVKVVAQIMGTNNIRGMNGMQNGMNHGMPGGGNGNMHNGINGGTFSRGDMRNSFRGPGGPMHPGGMPNVAGMRQSYPRGINLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUS5</accession>
    <name>A0A0N5BUS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUS5"/>
    <dbReference type="WBParaSite" id="SPAL_0000959400.1">
        <property type="protein sequence ID" value="SPAL_0000959400.1"/>
        <property type="gene ID" value="SPAL_0000959400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000959400.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18664" checksum="FC62DC5B464FA182" modified="2015-12-09" version="1">MEAQKANIRAILKKLSDYTRSKTSNTPKELFGVIIEEIPEDDKDENMEVEENKIEFSNKVSNKGGENIDFDVAMECLNALLLNVRTLKKRAEDFSQKTQCVKGYASECLRISQKIKILNDQTQPLCAKFEPRLKIIRKKLADIKIKTGEELEFERRRRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUS6</accession>
    <name>A0A0N5BUS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUS6"/>
    <dbReference type="STRING" id="174720.A0A0N5BUS6"/>
    <dbReference type="WBParaSite" id="SPAL_0000959500.1">
        <property type="protein sequence ID" value="SPAL_0000959500.1"/>
        <property type="gene ID" value="SPAL_0000959500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000959500.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46948" checksum="DCBE383610690C81" modified="2015-12-09" version="1">MDSNYFSHGTLEQDIRMENMKQASVTITVNGISYCQVASICDIESRKFNFTGDDKIKWSLKLCPIDASVTGRNFFDIYLNIEESSYEEIITLCSLSVLNVGREKKNRYVEMFKFTSNNFTWQQPISIPKEIILEYKNNISRDDKLTFRCDVFYYCKKINNFDTSKTAHVKNPLKTLSNNLYGILKSSKFYDCIILVNSYKIYANKCILAGRSKVFDTMLKNKRDESELSIIEINDFHPSVVEETIKYLYTGTFPNINEITLQMLRFSKIYKLDELKFMAEESLIYSLNNDNIYGYFIASELYEAKILQEWCLLFIFLNAENLVKTPQCKEFLVNQPFLNNKISQFVADDDTYIIMENVKAFLLNEDPNKHGYHGFTLAVGGKSDPHAYNSDGAGYVMSRREASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVL4</accession>
    <name>A0A0N5BVL4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RPOL4c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVL4"/>
    <dbReference type="WBParaSite" id="SPAL_0000987000.1">
        <property type="protein sequence ID" value="SPAL_0000987000.1"/>
        <property type="gene ID" value="SPAL_0000987000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000987000.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22962" checksum="00E2F1ABF861D0DF" modified="2015-12-09" version="1">MVEIKLFFKVVCPCFFGHIDDEVPLMNDAIESTDSQMNYSLNERETQSVETPNSRKSSKRTFNNSRYRKNEVKRDDETERALNEILDRTRDRMININEFREEINFDKFRSMIDNEKYMEEINAHDRLSKDIIKQDCLLEPTINDDNLIELLTKANGLSIEESEDMKKMLSCFNDKLKTVSAFEFDEPLVVYMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA1</accession>
    <name>A0A0N5BWA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA1"/>
    <dbReference type="WBParaSite" id="SPAL_0001010250.1">
        <property type="protein sequence ID" value="SPAL_0001010250.1"/>
        <property type="gene ID" value="SPAL_0001010250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895229" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010250.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15758" checksum="D40489CF055A67AD" modified="2015-12-09" version="1">MFLRYFILFFVVWYSLISANSSGNQEITIGKNRLPKRSKILSRYGRAVLSRYGKRSNHYMYEYFKKRQNFYPIYGNSYIISPWSSFEVDVNCIKFCMNRGCTHCCRSKDSPRDINCLEKAGFFLQGTGEYTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWJ7</accession>
    <name>A0A0N5BWJ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001019100.1">
        <property type="protein sequence ID" value="SPAL_0001019100.1"/>
        <property type="gene ID" value="SPAL_0001019100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001019100.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="55537" checksum="1BC666D58DDB5BD4" modified="2015-12-09" version="1">MDFQEEKFTNFFQLDSTQNLTSLKYINEDNIKKLDLEEIFIQIGYLRKENLFLRYYKTLYESDEIKKVLDQLEATSKELRKQSEHEKKYLENIYQHSVKTVLQQKGEWDKKSKESNSQYKLSLENLQKSEKELENNKQKNNNNIKILEIFYEQILRLLALYENGEIKLKDNYGYNLKNCSELIKSFKQLLLEQGTFHLARNKWINGRTLVIYSQCQIAFGIKKWEKILTEDLYNEKDRYFICAESKNNFIAAIQNLESCQIYMGNKITFPFVTKKQTSESLDLLTIFFEDVLNDTNARKCLDIFKKLHSDITNLIQWFNNVISEQIMKDLEKNCTEIVKIEEKLHEETKGIVSNKYKDINQKIGNYKKEKWEDEVKKLKSMKFINYDMTMIMNLSKPDDYKNFKNFSLAKEQNLVFNVQQKINQLEAQKIIFENIKKKEIKTQENKLENELTQRKTNKGSYNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWP9</accession>
    <name>A0A0N5BWP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shugoshin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWP9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWP9"/>
    <dbReference type="WBParaSite" id="SPAL_0001023900.1">
        <property type="protein sequence ID" value="SPAL_0001023900.1"/>
        <property type="gene ID" value="SPAL_0001023900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001023900.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52645" checksum="D2F283CDEAEBD6B9" modified="2015-12-09" version="1">MNFEDISLDLNSYVPLGKEFSSERSIDVSEERKKKKLERSKKLEELLLLGGDDDSPSRYSNAELLKITKRKKRTTDKVIKTDFSILIEGKTTETLNEDSCAFFPPETPVKNEKKITDKILVPGTPDDKNIADNPKRNLKRKITFDDALCDEYEQNTAKKICIDIKVDKKISEEKSSNEIQSPSEEGVTEVKKEDTVTELRRSPRKKKIDCLMKTPDSKKNNTKKNSDIVHETPSFKMKTTRRKSNDICKISMLAQTNPIAKTPYTRSQTSSNFQIVDCSSRSNSSFSVSSSSFSKTKMPKSTSLSLLTKTVSRSRSKNNIKIKSKAPTDFSGLFINNDIEKRYNIRLNTIFKEVKKGEISHNDVYYGKNTNRTNIFSDEVIDKLRTSPRKKAEIAKNRTGRTIETNNQLNFSHQLLNTRNHSPSDYDKKQLKLETGSFFVKKALSSPTKASQRKIEKLKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ30</accession>
    <name>A0A0N5BZ30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ion channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ30"/>
    <dbReference type="WBParaSite" id="SPAL_0001102600.1">
        <property type="protein sequence ID" value="SPAL_0001102600.1"/>
        <property type="gene ID" value="SPAL_0001102600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF322">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="326"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001102600.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57754" checksum="F69C8ABD8484DBCF" modified="2015-12-09" version="1">MGSTAAGVTFHSYNQLIRNATLHTERSKSIAPSNVEPENLARGVKWDECPLRGDSDGDTECDDKSSTSNLTLLQRFLKLLKILLPHVGLNILLLSYITFGALVFMWLEGEHELTSRKTKLHDILTLYQKIINETISVCQSPNSTYVDYKYVDSRMRPLLSQLSRTHEFDDRFTDDGQLWSDSEEDMTTRWSFAAATLYALTVITSTGYDHITPATDPGRIFTVFFGLVGIPLMFITAADIGKFLSEIVIRSYGKFLDFCTWMASVMDAIKDYIFEVDDDDSLRSQKMHKKSNARKGMPLDGDEDDEDDRPQLPIASYFALIIGYCAIGSLTFNTFEKGSVWSFIHGLFFSFNTITTIGLGNIYVKSNLYLALCVTYVIIGLAVITASLDLCSSTLKRTFTRLHYFGRKIRGARRGIANMSDDIREAMRIIAALKKTRPSKDRITLEDLKRFLEVQEQLLRQPYVPYNVHIFKWIEDTYFQYLDDNGSLSEKSLPLQKSVLNNEQVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ77</accession>
    <name>A0A0N5BZ77_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ77"/>
    <dbReference type="WBParaSite" id="SPAL_0001107100.1">
        <property type="protein sequence ID" value="SPAL_0001107100.1"/>
        <property type="gene ID" value="SPAL_0001107100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733464" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001107100.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44572" checksum="ECD6805431BFC1BA" modified="2015-12-09" version="1">MKQILLIFLFISLCVAEDILDIYKRDLPDEWPKPHKRMSNTIKYYADSESITPVEYVLRDMNDTLCITFIRQNNKIIDSGINFYKSNSKSYKSNSKSDIILRDSKSKPTDIYLKESDLKYNKNSLLLLYIGLALGLIPEIARYDRDNYVTVNSNNIDSKYISYYKKTKSKTTYSTSFDYGSAMLLNSSFGSKNNKATYTYKLSPHYDSTIGNNILFSHNDNKRINILYCSKKKCDKYRKCQHGSFPQKQCKRCICQQYFHGKLCEKLFSNDKKMCGNQQELKSYSSSRKSLKKTNIRDICLYKLKSTSNKKKVEVTVKSLVYDGNVPCDGRSGLFIYYRSDKSVSPLYLCKNSSNIVLPASSTTVYIAINSPFDVKSSFEISYKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ92</accession>
    <name>A0A0N5BZ92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ92"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ92"/>
    <dbReference type="WBParaSite" id="SPAL_0001108500.1">
        <property type="protein sequence ID" value="SPAL_0001108500.1"/>
        <property type="gene ID" value="SPAL_0001108500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="78"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001108500.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44919" checksum="75A5DBA37FBC2C06" modified="2015-12-09" version="1">IPDFVEIDKLNEQLLLQWVHENHGHIGYNKMLHLTRNYVEEGEIQNLSGKIVKILKSCLPCQMKHKAYSREVTETPVVATAPGQLLAMDILGPMNETERKNKYVLLTMDVFSRIVTLIELENYKLDEVSTKLWQRVFLQYGYYHTVRCDNSGNFKNQQLEDWLANMNIQLDHSSEYHHSGNSLAKKYIGAAQQVIFKLCHNNPTQWDMCLKLAEFTLNTSTCSKTGYSAFFPMFAREPVLPLTLLTNKIPYAMIENTPTMAHLTAQLKEIFEDMHELRIDEELNGKTTKAGCKSRQWFLNTGYIELKVRDAILIMVHRKPGISTKLQPTYDSKIYHVVSISIDYVRIKGEGDRKSMVLHRTLIKKISYSTPNKGGSSENGENPTDIGKGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZZ4</accession>
    <name>A0A0N5BZZ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein male abnormal 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZZ4"/>
    <dbReference type="WBParaSite" id="SPAL_0001133100.1">
        <property type="protein sequence ID" value="SPAL_0001133100.1"/>
        <property type="gene ID" value="SPAL_0001133100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF1">
        <property type="entry name" value="PROTEIN MALE ABNORMAL 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001133100.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32467" checksum="922115B7415372A8" modified="2015-12-09" version="1">MFIVNKLKFILLYSVIWLLIYAYLSEESIVVIKRLSKEQCEKNPCLNGGKCVPGNIGCTCSKGWMGKYCHRRCRNIYKSCDRWAMEEKCEVVRSQTNFFDINCAVSCNTCIPDPSIKLTPIPLAPALEPVQFILGSWYSQASKGLRYPTDMYDGAYEETINFMPAEVPMFGPPSLNVTSMSVVGNDVRLSHGFLTLKPNSNPLEGALLSSSNEGLNIVELGTLSNNALTLNITYMQVHPSMDPSILPLGGTRRFKRVGQNLEMTVAKLFSDNKVVQFKKIFRKLKNFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0B7</accession>
    <name>A0A0N5C0B7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0B7"/>
    <dbReference type="STRING" id="174720.A0A0N5C0B7"/>
    <dbReference type="WBParaSite" id="SPAL_0001144600.1">
        <property type="protein sequence ID" value="SPAL_0001144600.1"/>
        <property type="gene ID" value="SPAL_0001144600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF2">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="425"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001144600.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="59205" checksum="D4D92FC6371BF5EF" modified="2015-12-09" version="1">MKNNNPKTSRQKLNISLLRCQQNNKPPLKESSFGGNVEKNSNKSQSTNYRTKEYRNLNRLQYTPTVPSIQKESTEVTARQIPMKTDKKSSNDINNSLYFINHFENPQQDKVKSSFSLSQSSTITDPYSKDKKKVIPKQERSKTLEDSTLNKNKGMLDTFYERSLKILKPIALKYSDLVLSTPEVVNYTINVNVCPKLKDIVGYEVNEAIFDRNLKDFIIPELKIPLKKHESDFLATRKHVIKLDPFFRTSFNANINKCRYKDVYCLEKTRVRLQSTPGAVNDFIHANYVSIRDYIDNYKMICAQGPLPSTIIDFWRMIMQEKCQNIVMLTQCFETVGKIAVKKCEQYWPLEVGESMTYGNIKIRNIKVTKLSPDIQVSDLEVKDDTTSLNTSHIIMANWPDKSTPKVDFTMFILLQQLVRTSPSVVHCSAGIGRTGTLAVIDMIMARLSIDCPPISLAAMVQNLRLYRHGAVQTESQFSYVIQVMLQLAQSRGIISEKDIATWYMKNELPAGVNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1H8</accession>
    <name>A0A0N5C1H8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1H8"/>
    <dbReference type="WBParaSite" id="SPAL_0001185200.1">
        <property type="protein sequence ID" value="SPAL_0001185200.1"/>
        <property type="gene ID" value="SPAL_0001185200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001185200.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26911" checksum="67E3B9481C8A3C29" modified="2015-12-09" version="1">MADIPYEELLDLPINGVQLNERNNEEQEIVILENNPEINFSNDEMDLVIESVLNRYSRTLKEMSSTVEAVLLLLELDEPVTSLERKLLWASESHIHLLKFYIRRKNELLASLGEDPSSNQQVELEARCQASVSKQLDYCVIRTTDDLTTVYQSICRIEGITVQICVNGFEVVMFPSTIALPTLSALRIKYISGKLSGILPDKLKFLWFEGSIKVSETSPLTLSGLSSLEILVVNTCSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1R6</accession>
    <name>A0A0N5C1R6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NBPF</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1R6"/>
    <dbReference type="WBParaSite" id="SPAL_0001193600.1">
        <property type="protein sequence ID" value="SPAL_0001193600.1"/>
        <property type="gene ID" value="SPAL_0001193600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001193600.1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4739" checksum="B8DE8FB367A150AE" modified="2015-12-09" version="1">NRIQLQELPSKLTPNEHIETDSVEGAMENHSLTSIAFEENLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1V6</accession>
    <name>A0A0N5C1V6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1V6"/>
    <dbReference type="WBParaSite" id="SPAL_0001197600.1">
        <property type="protein sequence ID" value="SPAL_0001197600.1"/>
        <property type="gene ID" value="SPAL_0001197600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895316" evidence="1">
        <location>
            <begin position="19"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001197600.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="79128" checksum="8785D521B5355AE1" modified="2015-12-09" version="1">MKFNTLLFLLNCLYFTRGLKDGLENNLIYCDFDNDDLCGWINYKNYWKITENVDLDAIHSINTSPTGVGSFIYIQKDPSSDDPGYLISPEITTTESSNIKIQFYYRKNSISPILDVCVTKGDITKLRCLESISDKGLQQWIFKNIRLPNQIEPFKIVFRVRNMQSIMDVVAIDQVNVEIVPISRNGVRGIKSQKSNNDIESEQKVNNNQKLTSLGGGEEKKLEVEEKKVFGGNVNSPSIPSFNYGEFPSFAQGVDIFRPPESIRGCLAVRCSFMNNNCFWSLDSGWRRIDGTLAIDKIGTESITSGAFLVPLASFFEFDLWMSNSATVSIIQAYDNHEEVLFSQKGMSSNGWHRFRIPLQAGFAPSIISIKANINKNDFVTISNVKLVNSNGEEITCETVQTEPTQKIAVKQIINKNHLTNSNSRISVQRDQPILTRLNGMPVILPTPIAMTPIKPMRYGNFERLTSLQQVNSIYENTKTLKPRIYPSSLKTSTESPDAAFSNLMKLSQQIPNEWRQKIINTIIPEVNPNQKDLFVQKGNNNEELNMGKLISTISGQPVLENQLKHLAQRFGFTGINDPRAIELFQKFVNNPILNKKMAEIIKGEIMKTDKSLVNVKTSVPPIIPVNVDVKDFERVFKEQITKDSFKNLQKDQEISDDLVKNFASIVKLPPSHKDDQEALTRSNLDFVVHNALSHADNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Y2</accession>
    <name>A0A0N5C1Y2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Y2"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0001200000.1">
        <property type="protein sequence ID" value="SPAL_0001200000.1"/>
        <property type="gene ID" value="SPAL_0001200000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001200000.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21192" checksum="F801A0DBA18D5BD7" modified="2015-12-09" version="1">MTGTKKPLSKEEVAALCGEKDESTKDFYFQQTMLRIKDPRKSLPFYTKVLGMTLLKQFDFPEGEFSLFFLAYKPKEEIPDCEEKRAHYALSTHSTIELTHNWGTENDDNFEYHNGNKDPRGFGHIGIVVPDVYQACERFEKEGVKFVKKPDDGKMKGLAFIQDPDGYWIEIFHPCNIVKNPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C237</accession>
    <name>A0A0N5C237_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 72 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C237"/>
    <dbReference type="WBParaSite" id="SPAL_0001205000.1">
        <property type="protein sequence ID" value="SPAL_0001205000.1"/>
        <property type="gene ID" value="SPAL_0001205000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001205000.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42112" checksum="74A0BDDA37398677" modified="2015-12-09" version="1">XNLDNSSSNEVAPKRKSNRGRKSKKFLAEQAAATAVASKRKSSSPTPVGDTLSVAEDNVLENHDDTSNFETTSKEANKEDIKTEVMTSEKEDFEEDDDESTDTESSDAESIDFSKIETVAKGRPRRANAGNRMELLLTKEEKELMAEAPPEYQDYFNKKDDANITDGENDLFSEKDVDDSGDEVDTDFLDSDKSDDELDGDEAEKNILAIERNERRGLKRKYKSTALDIPISAYTVPPNVLSPEEHEKALEKSLKIAEENIASLQKYQAMEIETKNKRFNKNKKKMRPTDVDIIIKKGGERLLHLAVEPIHNVPKKGERLICAISGKPAKYFDPLTEIPYYSIEEFKIIRKMYEEYLNPVEGDFKNLKVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C279</accession>
    <name>A0A0N5C279_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C279"/>
    <dbReference type="WBParaSite" id="SPAL_0001209125.1">
        <property type="protein sequence ID" value="SPAL_0001209125.1"/>
        <property type="gene ID" value="SPAL_0001209125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001209125.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11016" checksum="61054C0A51F45A02" modified="2015-12-09" version="1">MPLTIKQWEFKSVNKRQDELLCIRVKDERKMCSVATFEAINGRTNHWRHGREKVNSSTENINNYHNYSDFPMPDQRTDSLPSENSSQAKSQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Y2</accession>
    <name>A0A0N5C3Y2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ultrahigh sulfur keratin-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0001266600.1">
        <property type="protein sequence ID" value="SPAL_0001266600.1"/>
        <property type="gene ID" value="SPAL_0001266600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001266600.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13031" checksum="48B50947FDF8FBEE" modified="2015-12-09" version="1">MLGGCWGAAYNGCSGNSCGNAMMSPCQSRQCMAFFSSPAYQCRPGCTTPACCRSVVPNPCANCAQPQSSMNQMVQMPQMNIQIKSPPRCCPCCMPVCSKVCVMSGGCNSCYDYYSDMGYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C479</accession>
    <name>A0A0N5C479_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C479"/>
    <dbReference type="STRING" id="174720.A0A0N5C479"/>
    <dbReference type="WBParaSite" id="SPAL_0001276300.1">
        <property type="protein sequence ID" value="SPAL_0001276300.1"/>
        <property type="gene ID" value="SPAL_0001276300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="588"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001276300.1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125527" checksum="90137994B05C4FEB" modified="2015-12-09" version="1">MPIKGVNNIKNNFTTIHLWNFGTKPFNILKNTPLCLAVQVKPDEIISAEDEYIAPEANWEEDLSEEKRSSPLSDDEMLNIIEIPKQLEALILKYKDIFYEYMHDPGRYTGTIRHEITLEENSKIVRKPLRKYRPEQEEAMMNIINDMLRESQIEKSKSPWASPVLMAKKKTGDWRKVVDYREVNLVTKEETSMLPLIEDILEKVSGKEIYLTIDLASGFFQIPIAEKSKEITAFITPKGLYQYNKVEAIDKVIPPKNRKELRTFLGATNYFTRFVLNYAKIASPLTKLLNEKEDFVWTEEQETAFNSLKTKLKEAPILAPPDINRSFAIHTDASEYAVGGVLLQEDQQDKRLRLVACVSRTLNSIEKRWQIVEKEALALVFSIKSFKYYIEGKTTDVFTDQRALLAIKSAKENQTKLRRYQLTLMAYNLNIFYKEGKANVIADLLSRNPEEILSEPQLAALVLKKEIHDEQWKSLPPIRLEWFKLNEKEVEELSNRYKDQIKIIDKIGYIKILGREKIYVPGKVRNRLISEYHSNIHLGAHLGSKRIANLIKQHYWWENMKINIDCEKCQKIKFAPNITSHWEGTWDVPKGPWIRLNIDIRGRLQTTKRRNEYLLVIVDDFSKYSLAIPMRNIKSETIINTLIIHVFTIFGYPEALRLDNASYFSSKEFEEFMCNSRIELIKSVAYNHNSNGEVERYNRTINEIIAFYEADEEWDLIIPVATLTYNNQIHTTTKAVPYEVIFGRKKITIERNLGLLNHLDNKEIQISHENLIAEIITTLNKNQEKKIVNKPEFFKVGDAVLKRIFGKTGNEGKTIGKYDGPYKITFLTAMDNPAGPLPYDNLYLIEALQECTQLIVSWDESGEHDNSLFHLRNHVSRIKDCERAIYTNFYRKLAEIIHEIRGPVQEPTIHNIPLLRRQFFQTAGITSQEFESLTKQPFDVFIKRYEFENSFEFPTYNEVTFKVATVAMLMHPRARRATLRRSQSVQTETDNPLVAVSQLNEQPPPRPSINHTPQQAPAPRQLTRDDQQHQKNNLRPRILNLRPASFGIQPIMVLAPPPTPNWGATPIAGNINGPQGNAPLPTSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4G0</accession>
    <name>A0A0N5C4G0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4G0"/>
    <dbReference type="STRING" id="174720.A0A0N5C4G0"/>
    <dbReference type="WBParaSite" id="SPAL_0001284100.1">
        <property type="protein sequence ID" value="SPAL_0001284100.1"/>
        <property type="gene ID" value="SPAL_0001284100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001284100.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56563" checksum="A5604A7EE6F07733" modified="2015-12-09" version="1">MFISSPTGFCGKKDVYHNKQLIAIGSFSEIYKCLSKKNGVVALKIEKSNCYEISSELLFYHTCLEQNDVEANFSSFLAPVPYILDEGMLGDKKFIVLPLYSSTLSNYIKEYKENCVMSSEEVRIIIKQLLQAISYLSIFRVSHNDIKGDNIMLRFPQSVNAVVLVDFNSASFIYEKNTSPVSIIQRGTPAFCGFHYHEGELPTFKSDLTSIVFNGIYWLLGELPWTSTESDIYKSKMSFLKNPSMVFNKLKIKEKNLIELIWRKMLEIKGIEVPNYHNILEHIDKIGKIENSPIITSSFNDTMVAPLNNRLYNLLLSDNKSFPFNFQNIRNTMNDFDVIQKKNIPQIILVNYQSFNHQGYISFIDVSKGKHFNIAKILPEDCGKIEIMLHGLIRSFKSLKENKIKKLNVFLIKKPFFDFLRNLMNDGENTSDINDKIKKLVDELRTLSTSFILVDIILIKIDMNNEILKYCADKINKIQNSDILTQQVLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4M3</accession>
    <name>A0A0N5C4M3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4M3"/>
    <dbReference type="STRING" id="174720.A0A0N5C4M3"/>
    <dbReference type="WBParaSite" id="SPAL_0001290300.1">
        <property type="protein sequence ID" value="SPAL_0001290300.1"/>
        <property type="gene ID" value="SPAL_0001290300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0939">Gibberellin signaling pathway</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 14" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="15">
        <location>
            <begin position="545"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001290300.1"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125896" checksum="C62634F9A2EB47DA" modified="2015-12-09" version="1">MMDSINNYFFQNSLLDRTMGPLNGGSSIIIAHPQLQVSSGNYTGGGVHTNINNIVPTGVMAGLSNNMLVVESTAGSLGLTDLPTLKELAHRFYQSGDYHNAERQCLSVWQAEPSNVSVLLLLSSIYFQKKEYEKSLQFASIALTKNPGLAEAYCNLGNVFKEQGQYKEAIENYRHAIELKSNFIDCYINLAVALVSKGDLEQAVAAYSTALQLNPTLYCVRNDLGNLLKAMGKLEEAKICYLKAIETNPSFAVAWSNLGCVFSNQGEIWLAIHHFEKAISLDSNFLDAFINLANVLKEARIYDRAVATYLRALEVQSLVSNPGNSIAVIYVNLASAYYEQGHLDLAIETYRRVIDLQPCQPDTYCNLANALKEKGFVEDAELAYNQALQLCPTHCDSKNNLANIKREQGKIEEAIALYRDALTTCPTFAAAHSNLASILQQQGKYQEAIYHFREAIKNSPLFPDAYSNMGNALKEMGDIASAVQCYTKAISIDGGFADAHSNLASIYKDAGNYSEAIKSYRTAMRLKGNQFPDAFCNLVHCLQIICDWDDYDFRMKQLVAIVADQLNKKRLPSVHPHHSMLYPLSHEQRKQIAERHANLCWDKVQVYHKPPYNYPPRNCLKLGGRLKIGYVSSDFGNHPTSHLMQSVPGLHDRNKVEIYCFALSSNDGTNFRQKLSDEAEHFIDLSNLTCNASAADFINKLGIHILVNMNGYTKGARNEIFALKPAPIQVMWLGYPGTSGASYMDYIITDATTSPLELSHAYSEKLAYMPHTFFIGDHMFMLEHLKERVIVKDKSAAILSDKDNVTVCNATNLEPLLSKVELVPKVIETEVPHAPENEVKKTEVKMQILEVPTTEPLKDMIERREIVVSVEGVRVQNGLDTLSRTHVKAANGEEVPDTIIVSSRTQYNLPSHAIVYCNFNQLYKFDPKTMDCWIEILKKVPNSVLWLLRFPYHGEPNIIKYCVERGIDGSRIIFSNVAAKEEHVRRGQLADVFLDSSICNAHTTGMDVLWTGTPMVTMPMETFASRVAASQLMALGCPELIAKSRKEYIDIAVRLGTDVDYLNQIRAKVWKARTTSTLFNVKQYCTDLEGLFYEMWQRYEEGLPVDHITSIKQYSPSNTYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C517</accession>
    <name>A0A0N5C517_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C517"/>
    <dbReference type="WBParaSite" id="SPAL_0001304300.1">
        <property type="protein sequence ID" value="SPAL_0001304300.1"/>
        <property type="gene ID" value="SPAL_0001304300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001304300.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19498" checksum="8C1D394C5399C557" modified="2015-12-09" version="1">MFHVTAARIFIHPVLVKYLFTMVQFAICISKIAKTRFSLRRPMYEVGITGTVACKYPRLGSGFTAYVSEKPNTTKEYRPIAKFSGTYWEKFYIHKIFFSWRIPKNLYIKFFYQCSKIPSHCMQMIIKPIPSHMIFQSGTLTQFFNLGTFDVTGKSSFQGTCLRMTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5L4</accession>
    <name>A0A0N5C5L4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5L4"/>
    <dbReference type="WBParaSite" id="SPAL_0001324100.1">
        <property type="protein sequence ID" value="SPAL_0001324100.1"/>
        <property type="gene ID" value="SPAL_0001324100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001324100.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39344" checksum="410E03E757CE6429" modified="2015-12-09" version="1">MKSKSLTALLIPFFGLILGDISYIIQTDDIKLNPYYLLISDIAFGVCGGFTAIMGLINSYNVRYTNVSERGIRISRYEATIAFAGTLGSFTSGVIREKIGYTNVFILILCIHLVCIIYTIVTLKMEIQNIELSSSNDEITTMKNFFKNLIKPLSVDGMEKKILVLLFIILAFELFIYGGINDIQFSYFLYKFAWGDKKFGIFNGFLMLFSGIGTLIIYPFLTRQFNIPSHIMAVIGMFNKIIFLILSVIITSDSWIYIIIIPNLMTRFVATGLRSLASINTPVDEQGRLFSMIELTQGITSLASSAVYNSVYPKTLSFFSGFMYILTATTYIIPLLITFKIHKMLNVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5M2</accession>
    <name>A0A0N5C5M2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5M2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5M2"/>
    <dbReference type="WBParaSite" id="SPAL_0001324900.1">
        <property type="protein sequence ID" value="SPAL_0001324900.1"/>
        <property type="gene ID" value="SPAL_0001324900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001324900.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26304" checksum="CB71718E057BA743" modified="2015-12-09" version="1">MNRKERFIALTERLYVGYAKYVEFFEKEIERLEEELERKGNDKIKEQKQLEESSLYNSDKVNNNINYVDRALKEVDDGYEYLTNCRNESDGKINYDIKKELQVNNSITKTHIIINEYKSSCESLDKLRLENELELQKENYKIYNIYAEKILVLYYQLKEEESSVMVSSSSCNTIEKDIFNESGKLLSDSPYEDLIVNQNKNEKSTENTKLYKKSRGKLSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C673</accession>
    <name>A0A0N5C673_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C673"/>
    <dbReference type="STRING" id="174720.A0A0N5C673"/>
    <dbReference type="WBParaSite" id="SPAL_0001344700.1">
        <property type="protein sequence ID" value="SPAL_0001344700.1"/>
        <property type="gene ID" value="SPAL_0001344700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895">
        <property type="entry name" value="PROTEIN CBG03177-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895640" evidence="1">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001344700.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="45006" checksum="D1EB0B5FBD4F60C7" modified="2015-12-09" version="1">MLASKSFTFLLFILVISLSLLQASGIRNKRQCSCMQQQQPSCSCSQATQKSYTSQVQVSCGCQTSSVSTTQAPCNCNTQAYLITPIKQCMNNCQSTCQKTCQSSSSVSNKNACPAACSKTCQITCIKFSIPTAITTTTTTPSPQNNIFLISIQKVSCENNCQNTCGRNVQCNQQCLGICACEANCQTSCTSNKIASVDSCIPACQNACTNSNQQKEIQVQVGSCQSSCQNQCSSSDSSNICQTQCNNQCKCQNACISSCTEQNKPSQYCQSSCQNTCNAINAYVVSLPVASTQKPVDECNSNCQNKCSQKLNPATCITICQIQCDSQYETTTTTTLAPINYECTPICINTCVSSCMQNTQPQAQSQCAPRCNNACQQQCEQELEVSAIVISCTQTQTSSCSCPQNYSPCASNTQCCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6G5</accession>
    <name>A0A0N5C6G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6G5"/>
    <dbReference type="WBParaSite" id="SPAL_0001353225.1">
        <property type="protein sequence ID" value="SPAL_0001353225.1"/>
        <property type="gene ID" value="SPAL_0001353225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001353225.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11510" checksum="4033E1DB9755A2EA" modified="2015-12-09" version="1">MKAVRSKMNQMIMENQKKKKLAVEGSHSTPEQTPRDQLNIKVGDPVAVFFPKKNKFEACWKTDYIVVNITNDEGESLKIYCKKKNKSKGRPLVRSINEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Q4</accession>
    <name>A0A0N5C6Q4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">JNK1/MAPK8-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6Q4"/>
    <dbReference type="WBParaSite" id="SPAL_0001361900.1">
        <property type="protein sequence ID" value="SPAL_0001361900.1"/>
        <property type="gene ID" value="SPAL_0001361900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001361900.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="51145" checksum="9CBFD4A8688D6BA6" modified="2015-12-09" version="1">MDIDTLLNESPPPCPSICGRTNNSLICGPCPYGTKTFFGNKNSLCIPCIEKLSWFETCFLIFYFAVPFIINSKKVILNYFYVDSLSRWKYYENVEVYEDEKTFKLEEFDTSKDDHNSKDDDNKIENDTEEEDVIDEIEELDVIDRQSMSESDYEYEKRTIKENIMAYLPFIEHLIILILETLIPTLASIYLIPPSFSFKVYSCRTDDLRDWYPYFNSVPEFSKDTNFFTRRSKSCSYEIVFPLFSLPVLYSVISLFVYVLTRTSIYLLSRFRYTLASSPVHVGLWVLPIQLFLHIFFGGIIYTYFPFICIIYSFRQYSHDLEELSSPFLSSLYNELKSNLLFLFKIIFCTLIYYLAFFSMFSKYHESRLDFFTAAIFSIIPTVMFPQLKKFFKPFLKDKEANYQQHNGEDFFNSEEMLQLREALRERRNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6X8</accession>
    <name>A0A0N5C6X8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C6X8"/>
    <dbReference type="WBParaSite" id="SPAL_0001369300.1">
        <property type="protein sequence ID" value="SPAL_0001369300.1"/>
        <property type="gene ID" value="SPAL_0001369300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001369300.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="45735" checksum="117AF7F10AF4C53A" modified="2015-12-09" version="1">XGIISTYHLKNSDQDNLANHGNLNHEYRAIINNDISEFLSQNFQKESKTDVVLGEKRQAEGMRARRRRQERERMRRRKLQQERLRHQRQKQIMNRMRQQRKRQEQQKKRRERKRKEFARRRRQRRMRQEAERRRRLERIRQEQERQKIEEERRRSSTTTTTRARTTTRITTRRTTTVRVTTTRPPITTESHVTTTTKSRTTTSAEKQTTETTKSQTTALSKKQTTETTKNQPTTSPNKETSSTEDESKATSELLPTPGVTSSTRNGSLHHITSDIEEEEKQYSNEQFDQEQDVIESDDEYDYSQVDEDYKKDGDTKDNTEEDGDYKNENYDTEDNEDYEEDDDTMNNTEEDGDYTNEDYDTEDDEYAENDIDATIQEEEDKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7S8</accession>
    <name>A0A0N5C7S8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7S8"/>
    <dbReference type="STRING" id="174720.A0A0N5C7S8"/>
    <dbReference type="WBParaSite" id="SPAL_0001398900.1">
        <property type="protein sequence ID" value="SPAL_0001398900.1"/>
        <property type="gene ID" value="SPAL_0001398900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="71"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="252"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001398900.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46852" checksum="A61FB09D900D13FD" modified="2015-12-09" version="1">MSDNREESYEENNGFTEAGEHCESYGDNMVIVGNYDEVVESFDAMGLKDELLRGIYAFGFERPSVIQQRAIVPCCGNKDVIAQAQSGTGKTGTFSISVLQSIDTDLPETQALIMAPTRELAQQIYQVIVDIGYYMKVKVHACIGGTNVRDDQRILSSGVHVVVGTPGRVNDMIARKFLKTDNIKMFVLDEADEMLSMGFKEQIYNAFKALPHNVQVVLLSATMAQDVLEVTKKFMNDPIKILIREEEVTLEGIRQFYVNIGKEQYKFSTLCDLFNIVSITQSVIFCNTRRKVEDLAAQMKEQNFTVSFMHGDMDQQERNVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPVKRENYVHRIGRTGRFGRKGVAINFITDADQRQLQDIEKYYSTRIDEMPENIANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C865</accession>
    <name>A0A0N5C865_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C865"/>
    <dbReference type="STRING" id="174720.A0A0N5C865"/>
    <dbReference type="WBParaSite" id="SPAL_0001412000.1">
        <property type="protein sequence ID" value="SPAL_0001412000.1"/>
        <property type="gene ID" value="SPAL_0001412000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001412000.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10601" checksum="B9C14D84C8C160E1" modified="2015-12-09" version="1">MVSAFIGPKLSAFLMFMSGAGVAFLGILGAFFYSKAVTLFPDLHFPEHNLDPTDSEIEIKYYEKATQCWIATAMYAVTFILVLWQSRYNTVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8C5</accession>
    <name>A0A0N5C8C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8C5"/>
    <dbReference type="WBParaSite" id="SPAL_0001417550.1">
        <property type="protein sequence ID" value="SPAL_0001417550.1"/>
        <property type="gene ID" value="SPAL_0001417550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001417550.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9922" checksum="58A9303C71F6239F" modified="2015-12-09" version="1">MTITNIQHSIYTNIYKQSRTLNISTVNFEPYSFNKIHLNMYILRYSSLTIFTKNRQTIKESINKIFFCRFSQIEVRSLNEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C938</accession>
    <name>A0A0N5C938_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C938"/>
    <dbReference type="STRING" id="174720.A0A0N5C938"/>
    <dbReference type="WBParaSite" id="SPAL_0001442100.1">
        <property type="protein sequence ID" value="SPAL_0001442100.1"/>
        <property type="gene ID" value="SPAL_0001442100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="299"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001442100.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43729" checksum="E29278D8B4FFBEA8" modified="2015-12-09" version="1">MGKFKFTARPKGEYKLYGETYASATTIRTWYSLGGNQENNQNVANGFVAPRQPAIQAPQDSGPIIEEVNSDEEMSMVEKLSTTMNNTTITDDFNIEPTEEEPYTILDLDDNPRCSTAKRDRGLRNFDRDFFYGGPDVSAICGEGSVSSQLWTSGNKGVVHFEDVPSSGNGRGSKRNCPTSREVTFITPIRPSDRRYTPPLENKHQGSNNLRRNKSRSAGNINDPDLMESPESEDLDYSDEEDDDFSEADDVEVAYSEDDSSDLDDNELESVREGVRKFHKNAIAKNVKFIDKLRKEGKNAQGINRFSSSSALQIPRAPFHRLVKEIYQDITKQHCRLGKDVIDILQCVSEEYMIDCFKMANVVTAARQKVTLYPRDLRAARKITSMAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C979</accession>
    <name>A0A0N5C979_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C979"/>
    <dbReference type="STRING" id="174720.A0A0N5C979"/>
    <dbReference type="WBParaSite" id="SPAL_0001446200.1">
        <property type="protein sequence ID" value="SPAL_0001446200.1"/>
        <property type="gene ID" value="SPAL_0001446200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000061">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022264526" evidence="11">
        <location>
            <begin position="34"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="50"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="261"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001446200.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="47576" checksum="0ED4A78DD192F49E" modified="2015-12-09" version="1">MRNICGTLKSMKKLQLKLILIVIYLWQLPNTQCQYENYKYCSNETDIIDHLLMDTAQHYNRHQIPSYPVTVKIELWIQEVTSVSEMTEDFEIDLYVNEYWEDPALQYDYMRPCKRNLTFDYNMWDEIWIPNTCFINTKSAEIHSSPFRNVFLMVFPNGSLWSNWRIKSRGPCEVDLRHFPLDSISCYLTFESYNYNQREVHMIWHPEVPVSLSKNITLPDFDLVHFNHVAITKEYAAGNWDELTVSFMFRRRYGWYLLQGYIPTYMTVFISWIPFYLGPKAIPARTMIGVNALLAITFQFGNVIRNLPRVNYVKAIDVWMLSGIGFVFASLVELAIVGYVTRNDEKSTYKISNGTKKRRKKLSNKINCEQLDLLSRILFPGVFTFFNLIYWGVYMKGLRNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9G2</accession>
    <name>A0A0N5C9G2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9G2"/>
    <dbReference type="STRING" id="174720.A0A0N5C9G2"/>
    <dbReference type="WBParaSite" id="SPAL_0001454600.1">
        <property type="protein sequence ID" value="SPAL_0001454600.1"/>
        <property type="gene ID" value="SPAL_0001454600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001454600.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20498" checksum="C3A3C7D05BB9AE17" modified="2015-12-09" version="1">MLNIKQTTGTPYYKKANVLIERAFRQLHNICTKLITKETAQDWDELLLPMTYFHNTMMHGTLKCTPYEVFYGRSCRTPSHVMLGKQHNSLFDKDVDRWELTKNALKAYKHIEDTIVECRDKENKKNGGKDFPSFEKEEEVCIRRPPNKDEKIIPHKFQSSFIGGYKVFEDLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA60</accession>
    <name>A0A0N5CA60_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA60"/>
    <dbReference type="WBParaSite" id="SPAL_0001478450.1">
        <property type="protein sequence ID" value="SPAL_0001478450.1"/>
        <property type="gene ID" value="SPAL_0001478450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001478450.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10714" checksum="B88CD02B80F63902" modified="2015-12-09" version="1">MNFFKWLRTSAVTCCCNLAIWFRKACCRCLLLHLAAGALAPGLLAPGPLLLGLYLLTINLLSSPKLLEIKDPSDSDTKDLRIISSEFSSTGLTMNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAJ1</accession>
    <name>A0A0N5CAJ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001491300.1">
        <property type="protein sequence ID" value="SPAL_0001491300.1"/>
        <property type="gene ID" value="SPAL_0001491300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000344">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00697">
        <property type="entry name" value="TMPROTEINSRA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001491300.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32847" checksum="0ECD7715444A457D" modified="2015-12-09" version="1">MVDISLIVEIIQFMYKIPSMLLMILSIYVMIKEIKNKNVNFNTQFYIIIVCKLINEIIFVITNFIFFKLPKWGFYNSFLENNNWTATTFYILVTQQATFMFLITLLISINRCIAVKYPLLYNSYFSKSKVIFILLSFIILSTIVGLGNILFNARYIKTDPYGYFAPSLISKNEIYYQIFYQMVLFGIISIVTCIFNVVAILTLKKHNQIGKKHKKELYYIVYSIFVFITLLLVEAFFVCTFIAVKYEIQFFIHTIYFLHVVALDLTIVGDFYFLIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB41</accession>
    <name>A0A0N5CB41_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB41"/>
    <dbReference type="STRING" id="174720.A0A0N5CB41"/>
    <dbReference type="WBParaSite" id="SPAL_0001510500.1">
        <property type="protein sequence ID" value="SPAL_0001510500.1"/>
        <property type="gene ID" value="SPAL_0001510500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001510500.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38317" checksum="58E79BE82BB1BC87" modified="2015-12-09" version="1">MSEIVKLRSATHFQCHTSTAAYNLKKKKKILICKNTKIYDRYVIEKVVNGGNYGQIYLAVDEANRKNLILKVVHENYEPELLIMERNILMKLRGKPNIPLLLASGNYKDYVYIGLERLGKNMSEIRNLQKSKVFSPISVVKIALQAMSALELLHNNGYLHRDVKPENLVIGGSPDSISTIYLIDFGMARKYLDGNGKIRPSRKTVGFRGSMRYVSIELHKRYEHTPQNDIWSLFYSCIELGEGGLPWRSYANEDDILAKKSTIKPQELCTIMPKCFGDFGSNIGNAPYFECVNYQKLYKTLNSLFSKIEMDNHFFEWTKRASIYTTLKSRIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB84</accession>
    <name>A0A0N5CB84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB84"/>
    <dbReference type="STRING" id="174720.A0A0N5CB84"/>
    <dbReference type="WBParaSite" id="SPAL_0001514700.1">
        <property type="protein sequence ID" value="SPAL_0001514700.1"/>
        <property type="gene ID" value="SPAL_0001514700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="147"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001514700.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54631" checksum="CCA73E07863DD6C5" modified="2015-12-09" version="1">MCIVFEKNNITENEYNEKNKSYVWKIIKTYMNPFTILYKIQIARYYGNENDKKNANYLMNLPIGLPITIVYILILFSFLILIECGVLISIRNWIGTVRSIINESNNTKSRRRRQTFDSKTTTEEDINNNLDESCFISTIRPNDEPTIIMEHAKPYLRDVNLQRGLNFDVFPGECYCWYIKDDRERESIFNFMTGNIKKKEGSITIYDRDVNTRMRMGYSPSKNAILPFFTPFEHYKFFALLSGFRKSKLQSINMLNLTGLIQCRHKQLQYCDSNQKRRLVVGISALTQSGALFLDTPTEYLYKQGRNEIWELISILLVEKEESIVITTNNLEECNELSSRFGYINNGYVEYNVLSWSDVYSFGEQLFLRYGKLIVQPINCNDNVNDVNNLTKTDTTSITINTTSSTIGTKVDDDSDEDEEDEDDNKTEDEGDNVSGYCGIRSSLTVPHIIDYVVTNNSLEQIIFKIQNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC20</accession>
    <name>A0A0N5CC20_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC20"/>
    <dbReference type="WBParaSite" id="SPAL_0001542900.1">
        <property type="protein sequence ID" value="SPAL_0001542900.1"/>
        <property type="gene ID" value="SPAL_0001542900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="27"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001542900.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45960" checksum="402E00B8C6828C31" modified="2015-12-09" version="1">MHNRKYESKKVVLSPRQPPPYSSKLPKIPYYCDSELDNMKTSSTRRTVSYLIKVIFRQIERYTCLKFERNKTDQVKNSIGINFLLSNNSNNTVSLSNSSNCPTNVTLTNGTYMNTTLLSFYIGIALDIIPEVRRPDRDIDVNVTMDNVGEEFVQYYNKTNSSYITYLNDTEFDFRSPMFLGPDFGSKNNKSTYEVLLYKEDQYPFGRGRVFRHNFYKYIFYYYCNGSTIQNKCKYGGYSYPSNKCKCPEHLSGNFCTEFKNDSVIFTNYTKPVFLKANFTRKHYSVNLTNTIFYLNITSEHGYNVNATIKKITFSKTNCSSFGSSLEVLIRKDKGAAGIYLCRNSTNSKLPSLSNEVFFILDAKNENIFFNVTYRAVSRNKTRGKFEKALKNQTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC69</accession>
    <name>A0A0N5CC69_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC69"/>
    <dbReference type="STRING" id="174720.A0A0N5CC69"/>
    <dbReference type="WBParaSite" id="SPAL_0001547800.1">
        <property type="protein sequence ID" value="SPAL_0001547800.1"/>
        <property type="gene ID" value="SPAL_0001547800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001547800.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="32919" checksum="787457C7069A2724" modified="2015-12-09" version="1">MGAVMAEVGEVNEALTPIQRRRLQDRKEWEAFWKVKKLEAEGTFFPTMRYYAQRAFDFPATFVRENIVEPLHDKYKKPYYHRRLNRVPEIDQCGVNDMACFYEANEQYRLDKMVDGNILDILKQRVERCLNYDERNVNKCAKVIEDLEESELNFFIKYGEMGSEADCRDVYMKQKHRMIWERRHPEIMAERERLYKEHKEQLKAGKFDYSFWKKGMFFEDKKNCEAPYDFSLSKSTLEGDRPLSKDWKYYKKVNEDPEFEKEQGKTSNFRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDX7</accession>
    <name>A0A0N5CDX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4604 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDX7"/>
    <dbReference type="WBParaSite" id="SPAL_0001606800.1">
        <property type="protein sequence ID" value="SPAL_0001606800.1"/>
        <property type="gene ID" value="SPAL_0001606800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001606800.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11179" checksum="E99AEF427106D8D9" modified="2015-12-09" version="1">MEDDKYLLEYTAEELAKKTQQKNQLPLSKKDQPTEVSQTVERGNNLDGDNFFDDGKKEDAKKLPKDENGKQLPKDEGENVEKPSKRQPKMLPFKDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEA2</accession>
    <name>A0A0N5CEA2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHC_N2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CEA2"/>
    <dbReference type="WBParaSite" id="SPAL_0001619200.1">
        <property type="protein sequence ID" value="SPAL_0001619200.1"/>
        <property type="gene ID" value="SPAL_0001619200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="4">
        <location>
            <begin position="659"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="5">
        <location>
            <begin position="2127"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2465"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2665"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001619200.1"/>
        </source>
    </evidence>
    <sequence length="3056" mass="357416" checksum="BF5B76F1A0577B76" modified="2015-12-09" version="1">MDFNKCYEEKLAKKFPNIVGTHTLIKIKYTGKSLIYIVSKSSILENLFGKTFSFHKLAPGYIPKYLTRQRNKKLHEKPNRLVRHKLIKWYIDACIEEAQIKKLFATSISIDGAYAIAWYIYVKKYPLNNVDNVQNFYHMYSVSKPDYFISEQSSSLISCCSNVTSESELASNKLSNFTSGIIKECQIWINTAERISLIESKRDMYTSLIKEWSSKVNKLKLEVPIRKKRFCLIKTSSYTRSLIRNFIEKRKCLIFEWTKILNFTNNQYQTASDIKILIYEDIVKFKKALEEDLYVSIGDINTRVAEIGFEHEMTRAVHHTIVKYLEGLRSGDGIIYVECLVVNHELHLQNDKIKEDLKAPIRELCRLNHVKISFEDIEEWENLCENIIDNYLNGNKIFQSSTLNDYSELVLYENSDINNEHSISTEFYVYYYKLKQKLRFNNGFVKSGPFLINMANVISMIEKKIDEKLKLYNDIMIDNFRNDSLILLEKFSLINKCLSLRSLKLELMLKNRYEVIKMRQNVVGEAIDQLALLFESMHNILELLGFDAFEEVRMIEIVSLRLQLQGKFNEHEMFFQRRINIFHQFVKNQQSVIKNEVYFVMEKLKIINTFSVPGEVDDYIKSIQEFKPILEKLLNNIKTLNIYEKAVNFSESKFYQCEALNEHIISLGKLYNLTAEFFKYQNDYHNRLRYNANVNEAKMKAEYFLEQLNDISLLLEGYRASRHFCVQLQSDIEKFKHTFPIIEILSSNRFQERHWIKISNIVSIDFSEYINATVKEICDLNLYNFVHLLKPISFVAEREGIINDQLVKLDDFWSTQNIVLEMNDFWKLYLPTNLNIIISAASEHVSILKSFIKNEKLDSGFKSPFSLKNEQWLKQLSEILDITSKWKLCLSRWKKLAPVIKHNINVLYDEFREFRKCAKYFKLLEKHVKEDSLVLKFKDGKHVKCWIDLAQKHLSELMIKFRKFLNDIRKSSIRLGLISDVDLLLLLQEKPVDEFLKNVRKLCFINTKEIKLTSNGKNLLVKSLDDQEIIIIRDEINFIENHTKLSLVEKILSLEKVINNKLCELACNLSKKTDSRSIVSSIEEERYIPRISKILYDRFSKKSSSESSFNYLLTDRNHLKLLSKGDRKEVSIIINFIPILNYEKRHLNISLNFASSWSQGKIPIIRGNCYNGRLVVEQLQFLTFSGVHFVNCHKFISEDAISHILGALRQHSIILVLENYEQLLPNIRSLLFNKLNKLLTNEPCPRLVLISSYPTKEENIIQGHFFIEFTNNGDQINNNRECTNSSIMKTRNSSSQQNSNTGASVAQEITQSPTSIGRRLSSFSITNIPRHSICIIKSPKSVAENLSSFLSPSPSETNKSSGIRPNNFSKAFQRKCSTSSASHSSNDSKIFSFQDINLQPVDRMTIARINCIAFIGQASKLTLKEMMKNHDYSCKWIYFDAMSSYQLLHSSTEFGEPAEGYLLETLNYIQNSSSSKENFLIFCGSRHFTDQFPLFSPLFTKSITLLSEKERNMVSEDVLDDISISNANNEIKNYNYPGPYLTLPDGSNYLIPSNLKIFFCLPGISDINKSDVDWIKRCGVQTIMLQGLVDQTLYDSWIECIPKINEFIRSPEHIEVIVSTFESIIQPLWNFVNPPNYASPSLLMEYVVGDLIEGIKSVTSFNYGEVLRFIVTSVAMNYIIIYYSSENDITLFNKQIIMYGEEAENNFMIGAQLPDNISDYKLSQLEFCKWIEWKNEITFKSILDKELSLSEIVVTYPHFDRLLSFALRAFKSMKKHLLINGPKGCGKTTFVKRFIKFFDDDPLKYNIIWLNTTDRLNLTKVQSKFYAIIDEMEKNSDVYETIVIIDNFTFDEYIISLIELFLDQYTIVLANGTTKKCKIAEKVKFIIVMQNKSDISCIKKYDMFHELFYIIPLNFLRPQEIEEIIEEVFEWHLSIRSFSSEYQSLVESLAKTFIHIIINKECILPMAMKIVKGIMFSWPETTPDFDCFCRLFVHETLRVCYDNLDNEKDKDELLIKIDNSLKKYCQSSFEILFKKEDEIKDINIDSLSGLNEDEHVSFSTHFHEKNETLKVSKSFRICELLFTEISNGIDVIEGIPYGLLYNLVDFTSHMNNLVYELYRSNNIKKPMNLIVTEYIANQCQRIMRICRMSNEHMAIVGERGSGRRNCVKLANFALVGHIEYIYLSTISIEAFQESWRSGIVKCIENIASKNVITILLFYFEDEDIQNISYHSFLMIKQWFETYDIMEFITDDILLKLGEKIVESEKGLATQEQANNIRLPGQRKCRFLPVEAIKDIKVLKYVLSQRFSDFVHAIFLIPPGSEKFFKWCTINHFPPLKLNDVSIIIEKQLQDLLEKPNDKDINLLVKIISKICSSTEELVNNIHIPSLKKIFNVQTKSYFHVTSNFVQIFNKKYDKLFKKYKEFEIAISTLNMIDELSRIGGNINNNDLAKDLDNEELTYLMLSRERNKKREEYNKIVEYLENLESEKALLLKEILNHQTILKQKVEEPLIQIDNIKKVLLSTDYEEFRKLSFIKKPSAIVRDVVDGIRILLQPSYKPTKNTIQNWNSCQPFLRSKSLIDKLCNFNTAVVDYKLLGSLKRYNKFNIYRINQIVDESKVAYHLCKWLLATITLIETEKKLVDNKKNIIQMTEKIRDLDDKIYDYQKKKEDIHKRLQYLENETKECEHEVSRLRKQLDYRVRGSKIINNIYFLINNWKEKLSLVSEILRNLRGNSILYSSFRVLTSFLGSDIKLRALNIWKSILQDYGITYSDNFTDVDYFLKEAFIGTSWKMEWPLICPETPKKESSLITKQTDLLKSKILKFYPQSVVIDFALFNQNNDYNNNSNINRSKKCDNDYFKILLDNDNKTALQSEINSAIELENLWMNKSLIIDTLKVLRNGNQLILLNIPCVPPICWMHLIEREIEICNKQDELKKNEEERKSIFNTSTEIILQFNENRISVNKQFKLFMISEKDINSIELSFLRKVWPLTINEGMDLQQSSDYILDEEIVENLTCESETFLLRKMTDYSANDILESQEMTDQIIFHGRSFSISQQSRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEU5</accession>
    <name>A0A0N5CEU5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEU5"/>
    <dbReference type="WBParaSite" id="SPAL_0001638200.1">
        <property type="protein sequence ID" value="SPAL_0001638200.1"/>
        <property type="gene ID" value="SPAL_0001638200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF4">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895765" evidence="1">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="190"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001638200.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34004" checksum="5799DF660069BAB9" modified="2015-12-09" version="1">MMKKNSIFLCLLVSALYIFSSSYAKTDNLPPCDSIPKLLCCTDRVLEKCLGGCIDYIHSKCPHKLYKFERIPSHEKNDNEDKSIEAIPSEETYRISKTSKEIKPKLFGSSPKIIKAPIEQEPITAPKQVVLASPSFTPKAGGDYAFLNPKYPITEVSDKDLSPECGTEQSQPPYSPCISRKTVDELFLSCCEQHVPKNCHSLCSYEHREHVAAETLIQAVQQEGCDLKYMTKILYCANQNRDNRKCCSSLGLDAPDLEVGSRCLRMCNISPSGDSLSVLNEKDLVCLSNMNIINYCARAGIRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEX4</accession>
    <name>A0A0N5CEX4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEX4"/>
    <dbReference type="STRING" id="174720.A0A0N5CEX4"/>
    <dbReference type="WBParaSite" id="SPAL_0001641100.1">
        <property type="protein sequence ID" value="SPAL_0001641100.1"/>
        <property type="gene ID" value="SPAL_0001641100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001641100.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34064" checksum="F06B12CD95C29DBA" modified="2015-12-09" version="1">MKEETIEEETDDKESVGFIQKWIDSSKSDEKESSPGSIKSSLKKDDIEEECSLIDEEGIIDDMDPEEMDPVLLIRKYKELKTKYAKDSSKKSVTPEIDMEKVKQAQKEILTQQFNMPLDDVAKWDPDNPASTYQFMDLNQLVNEMILPNGTYGTEYMNSFNINPVAFNQPLNDPWNIMSAFTPGQNFFPPEHQMDNLFSNINTTLPSGGSPSYFQNSSFPSFDRTPQIPPTSISQTSIINNQTTTSSNTTQQQNNFPISSTDEFNIWNPLTQENNETFDSWMKHTGIDKIIDDDEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFA8</accession>
    <name>A0A0N5CFA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFA8"/>
    <dbReference type="WBParaSite" id="SPAL_0001654500.1">
        <property type="protein sequence ID" value="SPAL_0001654500.1"/>
        <property type="gene ID" value="SPAL_0001654500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895786" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001654500.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15484" checksum="BD2D036C518438C9" modified="2015-12-09" version="1">MKVFNALIIFLIISISIGFGSAFDIKVDLNPRCLCAKGEKVQTRLRLFNKYDPFYIFSKTVYGTCNRTQHLVLKDIYGGVLDTEAEVYHPLCKKIKTRMPVEKQCRYLESNDWYSYHYSCYEKNAKNETQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGB9</accession>
    <name>A0A0N5CGB9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exported protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGB9"/>
    <dbReference type="WBParaSite" id="SPAL_0001689800.1">
        <property type="protein sequence ID" value="SPAL_0001689800.1"/>
        <property type="gene ID" value="SPAL_0001689800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896061" evidence="2">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001689800.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22896" checksum="447C6AF8CCF9EB3F" modified="2015-12-09" version="1">MNFLLNIIFFINLSFLKVNCELSSFSSSKFGSKTPIEDKDSKEGKNKHNVKISFIRRRSSVRRKGSRKSVKGGRQHINDISDSNHLSGPMISKELYAGKKCVNYIVWHKVWCKCDYKCFADDHFLELKYRLIEELNRYREIHKMQPLLKDITLYKKAQKHAKNLAITRSLRRDNDIRTGLLMGIVYYSAASVMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGG5</accession>
    <name>A0A0N5CGG5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGG5"/>
    <dbReference type="WBParaSite" id="SPAL_0001694100.1">
        <property type="protein sequence ID" value="SPAL_0001694100.1"/>
        <property type="gene ID" value="SPAL_0001694100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895900" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001694100.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12752" checksum="AFEEA7B39C53BD9C" modified="2015-12-09" version="1">MKILTIAFLFAALAGVTFSNPQMSNIFSGSLCSPCKFLFQEVKKVMPTVNTDAEHQFKETVKETCDKNSHAIPLLEKVCTQVLDDLLEEVVKDVEILDEEINPEKICKKIRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGJ7</accession>
    <name>A0A0N5CGJ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGJ7"/>
    <dbReference type="STRING" id="174720.A0A0N5CGJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001697300.1">
        <property type="protein sequence ID" value="SPAL_0001697300.1"/>
        <property type="gene ID" value="SPAL_0001697300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001697300.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28684" checksum="34276D5739E09064" modified="2015-12-09" version="1">MLRIIEVHSIRYLSWSPCLLKDHYETLGVKKDASRSDIKKAFYELSKKYHPDMNPGNQEKAVEMFQMIKKAYEVLSNDFSRREYDETIRGPSRGYSDVSSERFTQNRRHYTDLDLDLKDLESFQRAARSRRGHHEKYDMPDEFFAKFGGKKFKSNYVEDEIPFTFNYKDRETARREAEELKILKEIEEEKAKSRYPLPTFEQLLRQQEQKKYEERRKYNLVALSVVGTVLCGVLYSRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGZ3</accession>
    <name>A0A0N5CGZ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Amiloride-sensitive sodium channel subunit beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGZ3"/>
    <dbReference type="STRING" id="174720.A0A0N5CGZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001711800.1">
        <property type="protein sequence ID" value="SPAL_0001711800.1"/>
        <property type="gene ID" value="SPAL_0001711800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1081"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1212"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1212"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001711800.1"/>
        </source>
    </evidence>
    <sequence length="1235" mass="143199" checksum="5982D5B0B96B8A0C" modified="2015-12-09" version="1">MPSKLNRLFQRVMSPNEVHKNSGERRDKRSQSDKKNITHSSPISKKTVVEIKNPVQRHSSNSTYIDTPNIDVRMATPGDIEYIDFEMSKELSLPTERPQSGNDNFVCPNDPSDEYSNDDDDYEEPTVMAVLEGSNIDGIRHIRSTETPKVRIMWSFVITVFVFLAIFQIVTQMRMYLNTPVATNIEALYPPKINFPTVAICNNNQYRLTYLTGARLLNRKSSSEKYEDNTTDIFDKALFLAKDIDAVKFLRNAAHWKSRMILKCELPNGTRCRISDFQAVWTLTGLCWAINTDPSNPIEITGAGNNNALKLLLNVERYERIENCNKKVRTESLPGLKILIYNQTDVPISSLDGVNVPPGYTMDIPFRMVHRVKIPGMNCIEESHEAKVKGKNMGDLSSVKACPIRRQMEDIEKKCLCSMRRSYDPNPVQNISFCNVEQYFKCVQPLVKKNFASGIARKECKASCEEIDYIAWQDMNELPSNIFPKLIEAEDEEDEQDIEDIETEDEFLTNDDSKGDEHFSCKENQYLDDGTVLRIKREAQRAYEKQTRYQEDIQLRTRRLIERFRDATDIISKLKWGWTVKNFEGVYERLLKNVECYGNMTSRHGDILNRIRDPNILSEGIKAAAIFRILDAKSFIRNATKYKTITDLKRDYIDKVEDTLKQVNDYHEMLLTMSKIYNEDQYQYKISNKLERMERIKELINQYESGKLQRRIWGDKMQSRNMRHFFDEDLYDSWYNIIIKDLDITILNSISKIEHLGEKIEGSWDSEGNIEFGAIVLFGDANDENKKILQSFIADVFPCTMENVRNETISMLNIYRKAMQNFQSAYTNLFKKELPEYLENFEFGDKFIKENFAQVNVFLHKMNIEYWKQESTYSIWSLACDVGGALGLFLGASLLTIIELIYLCIYYGMCKPKFWKNNRLINDTLHATKECSCGMWKKSQQKLRNIHEKNSYNFCVCCVKNGSKNKEENFEKNNSLIWFDNIIKNIKHKKSYGDDYEFNTTGMTESQLRYRNEKNLDPILTESLLKKEDSPVEFQLDDIYYNDMFKNNKNILCEFARKSDLNILEGNNGCLLVCNEEENDSGDKVKENKQNEVDNEHLSSISNFHEQSDTNYDKEKENDILINDEPSNPTNDIESVLLQSTEEESLKSIINSNENEINDTLNDVANEEKHELSEDTSHSLDEDLEILSNIPLLVLASPKFLGNEKSNIVKENSEDANKITDDVDLSSESDKSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH72</accession>
    <name>A0A0N5CH72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH72"/>
    <dbReference type="WBParaSite" id="SPAL_0001719400.1">
        <property type="protein sequence ID" value="SPAL_0001719400.1"/>
        <property type="gene ID" value="SPAL_0001719400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895876" evidence="2">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001719400.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36554" checksum="E8E987E14C7BEA79" modified="2015-12-09" version="1">MMKSFIKITIFIQCLIVIVRSQQETENTNNFSYVNGELEVFNGVDGNCTDSKYIFITFLFNKLTYGQFNGCLDTGIKIINNAITSRLDILNVFSYIYDKNKQFFDIEKICLYEKNIKLTKLSLTGKMTMYLFCSVNKITDTSIQPCIKSPSHSMETVKCGSDDSNILCREGSCGMYQRIIFDRKKNVTFSAEKIMCTHQIISFLCIERQKYRSYVTFDQSIINASSKCANYENFLYLVIDRYYSFYWLIQCYNHSVNNFVFPNPPDLGNTNDLDGITNSGQSLLQEFYLDFFIKLPQTLILFTFLGFIIVLFDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHG6</accession>
    <name>A0A0N5CHG6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atx10homo_assoc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHG6"/>
    <dbReference type="WBParaSite" id="SPAL_0001728300.1">
        <property type="protein sequence ID" value="SPAL_0001728300.1"/>
        <property type="gene ID" value="SPAL_0001728300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="1">
        <location>
            <begin position="316"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001728300.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="47211" checksum="13228739F77AF560" modified="2015-12-09" version="1">MERDDVLKIFCTDDFKEISDDEIKAANKWICSVLLEDLNTLVAENDESIQNFVFNLFESLLNKHGEDLESDSMFKKLKIFYRLFVNTSARSEIFKELSLKKLEIVHWLAILRFEDLLPETTYAICCFGKHIYNKYLLEKEFFRFINDLTTICNTNSKDHVHNSLIAFFWKLFEECPTFLSESFQSMGMRDYIYILGILIELTDNNYDTESTYVKVHENNIYFMVSLLERWCHDNFKEAETLRLPLHLMTILGTLAIHKRNYSDNVFTNKEILSSIKIILMNILGVEDKKGQIPGTSERFRALCNKDDDFVPLNDLKISCLRLVTNICMDNGVNQKNAGDVGLLYPVLQCSFDRTTLDVALRKEWSVICIKALTDKCEENQEFLRDIKNKLSSPVVESLKEKTIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B206</accession>
    <name>A0A0N5B206_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B206"/>
    <dbReference type="WBParaSite" id="SPAL_0000010900.1">
        <property type="protein sequence ID" value="SPAL_0000010900.1"/>
        <property type="gene ID" value="SPAL_0000010900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733375" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="35"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000010900.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="45205" checksum="40D7913E0A3CEDD3" modified="2015-12-09" version="1">MIFILLLFVLSNLTFAIDLENSLLENNSLIERKKRAILRRKHYIWREKEITYFVSETLNNHLIKRALSRISTETCLIFKRVYNRRDALFLYLPGSIYETNLGRRKEIPHKVYLPELNEDIRKILRGTLRALGVDYEHNRYDRDKYTKIDEKLINHKFMKNFKKNFRGSATTYGTSYDYRSIMHFSESECGNSGRVIKPKDKLMQAFMGKSEYLTFYDAKVLNKVYCNYPRIRHPRCRNYSYQSPRLPSQCRCPSFVHGPDCRTPLVNHNLCTRRNRLFARKERNIAFLKVGGRCIFYIYTEHHKKIRMKLSYFDNNIRNHTCTERNSIEVKYRNDLGVSGVLYCPSQNSLEVVSHGHIILLQSRLPAREIKIKVEYWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3C5</accession>
    <name>A0A0N5B3C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YopX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3C5"/>
    <dbReference type="WBParaSite" id="SPAL_0000057700.1">
        <property type="protein sequence ID" value="SPAL_0000057700.1"/>
        <property type="gene ID" value="SPAL_0000057700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000057700.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16809" checksum="B3FFE19FEE664C93" modified="2015-12-09" version="1">MTSKFTNYDYPDDDKLAHCFSNIKKTISISSNEKSLTQGYVKEFDIINECGIIVSIKDGKEFYITPETFFYNIYGVTILSLYSGEKVLFDYSKSNDIKIIINVYSCDGKEDIRNNLEDQAWEKYYEECGDCIWCGKSCHDGNHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3H4</accession>
    <name>A0A0N5B3H4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3H4"/>
    <dbReference type="STRING" id="174720.A0A0N5B3H4"/>
    <dbReference type="WBParaSite" id="SPAL_0000062600.1">
        <property type="protein sequence ID" value="SPAL_0000062600.1"/>
        <property type="gene ID" value="SPAL_0000062600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="14">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000062600.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34065" checksum="16A33FB6905B2F47" modified="2015-12-09" version="1">MYLNKTLKKFFSTTIKNMKNIEKISVIGSGVMGSGIGQVSAQEKYNVIIIDRNEASLHNSKIVISKSIDKVAKKKFCDNLHDREVFKNEVLDRIKFTTNLKYALCGTDLVIEAITEDINDKQKLFKIIEENTKDDTILTTNTSSLSIARISENLKNKQNFGGLHFFNPVPVMKLLEVITTDKTSNEVLETLMNYGNRIGKVPVKCKDTPGFIVNRLLYPYLFDAIRLYENNIARKEDIDKAMKLGASHSMGPFELLDFIGLDIIDKIMQQYPEKHSKVLKELVKNNQYGIKSGEGFYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5C9</accession>
    <name>A0A0N5B5C9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5C9"/>
    <dbReference type="STRING" id="174720.A0A0N5B5C9"/>
    <dbReference type="WBParaSite" id="SPAL_0000127200.1">
        <property type="protein sequence ID" value="SPAL_0000127200.1"/>
        <property type="gene ID" value="SPAL_0000127200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="234"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000127200.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40312" checksum="27B0BC04A26ED146" modified="2015-12-09" version="1">MTTERLSTIILEPSKISPENVEHRDHNNVESDVEFNLKINQITDEIHKQKEPVVLDWMREIIRFPLTTDACLHEKNIPKNRFQNILLYDLNRVRINDVNRGNDYYHASFVDGYDKQNRYILAQAPFDEDTEYDFWRMVVTTSPSMIVLLAATMDGDKGTAYIPQFWNVKKERKSYGEIVVKTINVAHSKNWDVYSLELSDKQNTKGVKNPVINLLHYKKWISDNKVPEYILDFRAFYQLKKAETEVKKIDGPIMIVCPTGTHRAAFFAAMDIIMDRINQEKRVGVKSTVQIVTKQRYGSFVFFEHYCNLVETIVKHCMASNIVDLHMLAEAELKRSNNNNKKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Z9</accession>
    <name>A0A0N5B5Z9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Z9"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Z9"/>
    <dbReference type="WBParaSite" id="SPAL_0000149000.1">
        <property type="protein sequence ID" value="SPAL_0000149000.1"/>
        <property type="gene ID" value="SPAL_0000149000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893810" evidence="5">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000149000.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35618" checksum="D0EB9AEF7EBD6E66" modified="2015-12-09" version="1">MLFNINILIFISFPLFYSVISGPNNCKPAGIYDIENNTVTEYLGIPYAKPPIKELRFMPPEGIGEFKTNETFNATIPARTCPQFIPPNIFPYNFSGFSIWYPPRNNVSEDCLQLNIWQPNITTGGVIVMIHGGAYYSLSASLDLFNGSVLAAVARSVVVTINYRVGALGFARWKNGVNITGNMGLLDQQMALKWINKNIYLFGGKNDSITLIGEHAGSSSAIAHLFAKNSSGLFKGIITASGTLENIWATQPNEYIENATMLLAQNLSCADKEDVLKCLQNVSDPMAFVNSTMIVRKQMGLSFGFPFAITQNDSKFFEKNISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6B2</accession>
    <name>A0A0N5B6B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6B2"/>
    <dbReference type="STRING" id="174720.A0A0N5B6B2"/>
    <dbReference type="WBParaSite" id="SPAL_0000160100.1">
        <property type="protein sequence ID" value="SPAL_0000160100.1"/>
        <property type="gene ID" value="SPAL_0000160100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052669">
        <property type="entry name" value="SL1/TIF-IB_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32122">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32122:SF1">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000160100.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="66471" checksum="89715BA6ABBF0D29" modified="2015-12-09" version="1">MALKRKHNSGVLSDEGSSSELEVTEDPSETITPSSFRRGNVWNLRSKNCYEFLQKSFDEITLSPPDRTYGSDAILQKIFIQQLGKAILFNSNPEDPKRLICYEYPVHIIRDYDLNDSELFSMLEMFLTSFGNRYYKPNYVRVKKKFRKPSKIAVDINKNYFSHSMYIWIRDKFDINTAIYQTHNKTRSPFLSVAIQQSYHTSFVLSKKSMYEDAVLCFLGLPLVKKEFCQTKKLKKGHYSRIENFLYLWSKILPDVFNFMIYCFMKNHLSEEKRNIFFTHMLNFCENLSSYGHMERDVLISCIFSVLTYDLQFRPEIAYDKYRKIEIKDVYRNRNSMIKYDAFLNVSLFLKWRNEEGDSDKLPVYLFEQLKEIVKDGNILEFMPIFEIFIYLICKYDLVSEHLDLILNAVKNYPTVMPRVTKRFCQEKQHQIAESIERSLDPSADLHSSHESWIKYLKFKSTQLDDNTDIEVLLQDIKIIVRLLDYGKWRKKHKIWKLFDKFFFIKNDKDPCLLEKFKIFFGERKNWWFNFHSIKVSSKTEVIRTKILNCIGELYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B739</accession>
    <name>A0A0N5B739_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B739"/>
    <dbReference type="STRING" id="174720.A0A0N5B739"/>
    <dbReference type="WBParaSite" id="SPAL_0000186700.1">
        <property type="protein sequence ID" value="SPAL_0000186700.1"/>
        <property type="gene ID" value="SPAL_0000186700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="7">
        <location>
            <begin position="183"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="8">
        <location>
            <begin position="343"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000186700.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="70698" checksum="EFE7514B9FD52232" modified="2015-12-09" version="1">MNHPNHCSGGIKRPKIDESYSEYNNLCSSELGRFMFTQNSGDRCQNENNIENIPTQNLIKHITSQQGLEFSNIINPLGLSSISSHEFKNENSNDHDSFLEALHDNDHNVSDATTLPHNESLNSTKHSLHESAIEENNKCFPQIYSLLKPTSSLLDIKNFPIPGGLTKETMMEYIKNRNEYDCRINIRSIVVGQKSYGEEKRFLCPPPIIELKNQAGWSKFRNSIDNFMHGKLLMFSDELQKGNFLTQLALQNDGSKIAGSAVLEKLDKVKQMSIEFDESNTLALLKNVYFSNVSQTLKSTKIIANLFFLYGIDLGTFETEKIRIISKPSKKKSNAVRNDTRHLFIESGYKIALFTRMRSQLVHTKYVHVKNGSFVSSPIQWSCLEIFIIDEDKTDLNKDGNCGNFFAKDGNLCFGNIVKIFNDEEGIGLPPLRIMKPDKQYIDIQEHLNIVNMNEPVCQLQKICLQDYHNPTKFISLINDTLTFCDAVIDEKDRNKLQVTDSCILQIVSAKENEYTFYHSSGIGPFPLTPVPVVKGVTETGSDSEYRIELYGSNFAPNQTVWIGSEKLETVMKTSVNMAAVPTREQLEMFREQKMNGDKDLTIYIVREDGIVYPTDKPLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B777</accession>
    <name>A0A0N5B777_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B777"/>
    <dbReference type="STRING" id="174720.A0A0N5B777"/>
    <dbReference type="WBParaSite" id="SPAL_0000190400.1">
        <property type="protein sequence ID" value="SPAL_0000190400.1"/>
        <property type="gene ID" value="SPAL_0000190400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000190400.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15951" checksum="428473D5B4FF5DF6" modified="2015-12-09" version="1">MAADASNKRTTVLVQNLEKQCSDFVISPNLIKLLSGFTAAITFGFGIKSALKYTKDVPPEELTRVKIISGAGFATKALATATILTVSGFTLVVLGVSIALNVNTPKQFGSRMKELFGDSLKISNTDPNVKKYDTLTELFEDVSSKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7G0</accession>
    <name>A0A0N5B7G0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7G0"/>
    <dbReference type="STRING" id="174720.A0A0N5B7G0"/>
    <dbReference type="WBParaSite" id="SPAL_0000198600.1">
        <property type="protein sequence ID" value="SPAL_0000198600.1"/>
        <property type="gene ID" value="SPAL_0000198600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="265"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000198600.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42848" checksum="39FB9C2C8CB9B344" modified="2015-12-09" version="1">MMPSLQNYQPRQIVKNLPQYQPQYQPQIYQPPQQQFPQQPQYPQQYPIQRQQQQQSYGIMKQSPIPQLMQYNLQPSQQQQYINSNVNANPHNISPVQVSSEGVVRDRIYQQQQVQPQFSQNIPKISPPIYRSNKIVKVVEKISSPQFQSPTYTQEGSFSLPDAPPPPPEKFLPESEYTPKIRVASESKVKNYMSTNFKSHDDISSKVQPSSGFEEKSIIRTTTPQGHVREKQPAVKIIEEEKKVSSHLSLSKGTSTAVNDVFLKCCHRKNVSPKCESRCNFDIINKKILTQMFLGSDPCPQSYGRDLFSCAAQDGDHTDCCRKMNVTRTTAGEKCLAFCKMTPDTNFQADVTYLPCWSVLNDIKQCFKNAIIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7N5</accession>
    <name>A0A0N5B7N5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7N5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7N5"/>
    <dbReference type="WBParaSite" id="SPAL_0000205900.1">
        <property type="protein sequence ID" value="SPAL_0000205900.1"/>
        <property type="gene ID" value="SPAL_0000205900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000205900.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30610" checksum="FEBD80DA6078FEFF" modified="2015-12-09" version="1">MMAVRNNNSVPCTSQYVKNDQSKLYNSRVQNNENNLQYNYNSTGNDDVNKGDKNNSLYNNNISSVGPSHIEITTEQLLKYDIQIFHAQSSDGTGQKQTIPCKRVIFETGQIGWMPLSMDQLMEIINNPPKEIPEQIQGNVNANIVSTSAPVVVQVVTSPLNNIPQSQIMETHNTENCDIDDKTIYVNPKQFERIMKRREARMKLLQEGRLPKERQKYLHESRHKHALKRVRGEGGKFDTGNESLIGDEESLSPNTKKVCEEEGEDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B858</accession>
    <name>A0A0N5B858_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B858"/>
    <dbReference type="STRING" id="174720.A0A0N5B858"/>
    <dbReference type="WBParaSite" id="SPAL_0000223100.1">
        <property type="protein sequence ID" value="SPAL_0000223100.1"/>
        <property type="gene ID" value="SPAL_0000223100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="4">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000223100.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="53133" checksum="48BA051111D932CE" modified="2015-12-09" version="1">MQRGAYQMGPSQMPPNGMMMNSIPPNTGTPPLQHSNYGMQGQMPIHGQPPGGMGPQHQMGQQINLESKIYDMNRRLCFFHTANIPEQDWAAWWNAFAFEFFDDLAKIQLHLYDENLPPQKYIFGRAIIPKFFKALFEGGIREMYIAPRMPCREGISNNYPLIFLDCDNALLHTKHERPAMLDVQTDIRFLMEFSLDMSGYRIRNWTLELKHCYYFNWKDQNQKNDNMILDKLKLGFAHLGLNQHALNTIKMASILEPMQILFSIHKTQGIQPKECVGHAVMQYHLKTQQNQRIQEQRMAQQRAGMAGPYGPGTLPPHMMMGMRPEETAPPPKKTRKRNKRNATASSGGTTTDPSESSSKKKSDGGSNNVKSTPINNNLIPATTPNGSQMPQAPYNDLMVVGEPTVMGGDYGSGDERKISRVENNPININDPSHQQQPISNQPMMQQNFQGMPNQQQSGSPQSQQQNLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B888</accession>
    <name>A0A0N5B888_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B888"/>
    <dbReference type="WBParaSite" id="SPAL_0000226100.1">
        <property type="protein sequence ID" value="SPAL_0000226100.1"/>
        <property type="gene ID" value="SPAL_0000226100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="151"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000226100.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49422" checksum="29398E6085F9CC1A" modified="2015-12-09" version="1">MTANSKLEESYIDKTNIKVDCILKCLEDKCSKYRETKGDSKVVKINTFDVSNGNGYVSRILKTTIFFDDIKKEPFICVIKVPSAENFVKLFSGTTGKFDEDWECTKLKSLAMFHNNELKFYKNMSKKIGEITLPVCYGGFDIVIGSQDGAIIMEYLTSSSGCISSHETLNIFQVKSVLNELLKLHVYSLTTGKEEKKIFKHKYGKEHSKIYVSLFNSHWESIKNVLSEQFINELESNYTKYIEHYINIYHYYIYKLPFISGNYSVLCHGDLWINNLMYKRDLKGHLTNDIYAIIDWQTVYEGSIGVDLARLLVQCTSPEDRHKIETTLLPKYYEDLKKNSSLNDKDFNMTYDMFMHNYNICLIDQAFHNITMISLIITELEKNEDIYNFNAKKDGLCLRLYWNLKDAFEKLEKIGTEFLNEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8D3</accession>
    <name>A0A0N5B8D3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8D3"/>
    <dbReference type="STRING" id="174720.A0A0N5B8D3"/>
    <dbReference type="WBParaSite" id="SPAL_0000230600.1">
        <property type="protein sequence ID" value="SPAL_0000230600.1"/>
        <property type="gene ID" value="SPAL_0000230600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000230600.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="36607" checksum="D7A2FF3CD41A9261" modified="2015-12-09" version="1">MAPIRVLVTGAAGQIGYSLVLQIAKGDVFGKDTPVTLVLLDIALMKDALEGVKYELIDCGLPNLYDVECCVTEEEGFKDIDYAFLVGAMPRKQGMERKDLLAANVRIFKSQGKALAQYSKPNVKVLVVGNPANTNAFIAAKYAAPTIPERNFSAMTRLDHNRAAAQVAIKSGVTVGNVKNVIIWGNHSSTQFPDVKHATVTKDGKTIDAYTAVNDTAFLQGQFIKTVQSRGAAIIEKRKLSSAMSASKAACDHIHDWHFGTKPNEWVSMAVPSDGSYGIPRGVVFSFPVTIDGATKEWKIVQGLELDDFAKEKIAATLKELEEERDEALKACEESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8W1</accession>
    <name>A0A0N5B8W1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Guanylate cyclase</fullName>
            <ecNumber evidence="3 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8W1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8W1"/>
    <dbReference type="WBParaSite" id="SPAL_0000248400.1">
        <property type="protein sequence ID" value="SPAL_0000248400.1"/>
        <property type="gene ID" value="SPAL_0000248400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF363">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893936" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="538"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="878"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000248400.1"/>
        </source>
    </evidence>
    <sequence length="1103" mass="126620" checksum="8340D6270E0C6161" modified="2015-12-09" version="1">MNISYFFLLVTLSSVIRTQKNLNLGFIFVGTDSENGDLLGFNLSAGIVPIVLERIRNESLLPQYNFTIYYHIDNCVESNSTGSAYELITNDKVDVIFGPTCSANAIRASLVARFYNVPTFIWGLVSTTQFSNIERFSNVYSANPLYFSLALTALDVMKTFNWTRFTFLSVPRSNRRCSVMYQDFISAANYFSYKTTMVYSFESSSPPLDREFDAFINETIIRARVIVSCFDRDEWKRAFLLKMYDRGLNNSEYVHINMEYTSTAFDSDDYDSDNNPIPFYMDMNTPTDGRDDDALKMAKRMLILDTQRDYFKNKEFDQEAIKRVKEWPFYCDACDITGKVALNKYARYLGDSIYNWAILLNKSLTNDSEDVFKNPNILRKHCLETIDGYTGKMTFDSNCIRLPYIQLTGIDGYGKQRAWFNYSFTSINTYERTDSVSPDTFAMTIFENWGKSIPLNEPICGFLHNLCPINFLKVYYKEVIIFGIIIIIIILAIFSGIIWYILKVRKRKEEELNKWKIPMIKLQNYSKNNEINKSVHSIASDHTFNSSKLGAVGRENTDTYSFYLYNGELVVGKKHKVNFYFTKDDSIELVNILSMDHKNINKFFGMCIDGPIPLSIWKFCNRGSLHEILQTDIPNFDEYFMISLANDIFQGLSYIHSSSINFHGMLNSKICFVNDRWQVKISNIPLKHLSANNKISKINLLWRAPEDLRQEFSIGSKEGDIYSFGIILSEIVSKGNFWNLEAREENIEELIYLIKRGDPSSIRPEIIAPPNIEVNPGFIILIKDCWSESPKNRPPLKQIEKLLKAFNSNGPKNLMDHVFRLLEEYALTLKDEVNERTKEIVEEQKKIDLLLQKMLPIEVANNLKLGKTVDPENFDNVTIFFADIVKFTILASKCSPLQVVTLINDLFTLFDNLIESLDVYKVETIGDGYLCVSGLPTRNGNLHAKEIAELALGFLKICHTFVIPHLPREKVTVRIGCNSGPCVSGVVGLSMPRYCLFGDTVNTASRMESNGKPGKIHTTESFTKLLNMIGGYKIEPRGEVIIKGKGVMNTFWLIGRIGENVTYFNEYNEIKNEKKPETVEDVTNVKQGMYREFDKKNNLENNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA81</accession>
    <name>A0A0N5BA81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA81"/>
    <dbReference type="STRING" id="174720.A0A0N5BA81"/>
    <dbReference type="WBParaSite" id="SPAL_0000295000.1">
        <property type="protein sequence ID" value="SPAL_0000295000.1"/>
        <property type="gene ID" value="SPAL_0000295000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF296">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="13">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000295000.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55481" checksum="F858E4A87EE15B2E" modified="2015-12-09" version="1">MTKNNMGLSEIFNSSGKDSRTGRLITIILPHLALYTIIFFYLLFGAIIFTKIEYHNDRQQQINKMQDILKIYYKTYNEARILCPDVVEVDPEGFKKHIFDSLSKISSHMLGKNFVLQTDEGNLLEMLEPRWNSLSAVLYALSILTTTGYTQVTPLTSLGQLFSILYGLIGIPLMFFAAVDIGRFLSDCVLFAYPKFLNIIGRIKKFAGLENMNNKKTIYGPSFCSSEIKTLADLKKSKTKKWLKARNKKRRTNKEEDVKKNEKSLPLSVNAAILLLFCTLGGVVYIVGGGSQKTFIEAFFVTFNLVANLTMSEMPTDISNVMTLVYIAFFVIFGLAVLSMCAELAATELKWLFWKIHYYGRKIKFKRKKAYLSHDEVKELLKIIEEVRQKYPHKEVITTLDILEYIKEMKAEVFFGNSEIFVSSKRRSTCAFMPTSFDALKFADENEIDGTSSETSESSLDYDETTSNKYRDIIVKVPEAYIASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAH2</accession>
    <name>A0A0N5BAH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAH2"/>
    <dbReference type="STRING" id="174720.A0A0N5BAH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000304100.1">
        <property type="protein sequence ID" value="SPAL_0000304100.1"/>
        <property type="gene ID" value="SPAL_0000304100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF4">
        <property type="entry name" value="PROTEIN LET-99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000304100.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="88532" checksum="428CBC43CFFA43C1" modified="2015-12-09" version="1">MLKYTIESSVDRNEYVSTIGKENDKPTTKRNPFKATTMWNDIENTFKKKMPLRKHRAYIWHYEDSFTGKEAIDFMIEMLPKLLVKDKEVSRESCRRLLQLFMDKKLFYNVRNEMDFIFRDGLTIYKFTSNIPEHNIKVKRSSSVNENTIRRISLRGGDIKARRLEDKVSTITGVPRPSLSHQDLSCIASSSPIVVQNSLDFKSSIDKNHHKQNISVCRSQSVTVNNSGPTSLNVLKSCDSSRRFPVRDSIRTMNIENRFTKRSGKEMHVDGEVRSQEDISSWRICILSFLREYLDPKGLSCLLPSHIDDIHVAFNCEKIGSKGIVKCFNQGEEMSSHVLKMMRFLARYPFDTKQFVDSNNLYVGIELDTYRNILTELKNNKTILPSRFNNLLFEIFKIYSNEEYLDTNFNNGESIFKRLGGTPLSRVVTRNTNRVFNPDNFLRNTKRSSFNSFEPKKSRRPIPFRVLQDDENNANTENAKPFKCDAELPGFAKSRLSCDLTVMEEMLSPYFSPNTARNLNSPYKGNNKIDDDILTDLFKYVLLLLPSQTRRKLHIIIRFMNRISLNHCLKLSKSSTNRIVILKTLTPLLIRCETDDDIKANSKLIAFIMDKESILFHVPEQLVRDRESYLCFPESAHIIRDKAFKPIPNKTVELPGFENIIHSPVQYCEKIDEKDFNKQAKESEKYLEDILNEYVNNKLFSETERRKKLKEFKKWYPEIYRKHFPDDMDDVESQTSKGTQSFVKRVRDFVRRTGQPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAU3</accession>
    <name>A0A0N5BAU3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAU3"/>
    <dbReference type="STRING" id="174720.A0A0N5BAU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000315700.1">
        <property type="protein sequence ID" value="SPAL_0000315700.1"/>
        <property type="gene ID" value="SPAL_0000315700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF62">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="15">
        <location>
            <begin position="161"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000315700.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="32406" checksum="154596B4B36A47B4" modified="2015-12-09" version="1">MRIGFIGAGKMAQALAKGLITSGRYEAANIITSSPKTDGKMLDECKFLGVNTTYDNTEVVETSDVIFVAVKPGNVAKVAAEIAPIFERKKLLVSIALGITIRNIETLLPPKSRVVRVMPNTPCLVGAGASAFSMGSACYDGDSTLVQDLLSTVGYAVEVPEVLIDPVTGLSGSGPSYMFSVIEGLADGGVKMGIPRDLSIRLAAYTLLGASKMVLETGIHPAILKEAVQSPAGSSVYGIHEIEKGNLKATLMSAVEAATNRSRATGSDNLPRHSMEMRGNVYDSSTYTKPYGIPDTLNTNSLKLTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAW8</accession>
    <name>A0A0N5BAW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000318200.1">
        <property type="protein sequence ID" value="SPAL_0000318200.1"/>
        <property type="gene ID" value="SPAL_0000318200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000318200.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7443" checksum="BB49CEA90932E546" modified="2015-12-09" version="1">MAQPSEISKYTIDVISDTASNIGLSFTEAQIKAIVFAINNGHSAKKLISVLSLGVSEETNSSSVPFNENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCV1</accession>
    <name>A0A0N5BCV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">PKD_channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCV1"/>
    <dbReference type="STRING" id="174720.A0A0N5BCV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000384600.1">
        <property type="protein sequence ID" value="SPAL_0000384600.1"/>
        <property type="gene ID" value="SPAL_0000384600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000207">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="16">
        <location>
            <begin position="109"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="15">
        <location>
            <begin position="418"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000384600.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="74521" checksum="1121D69F364F1CEA" modified="2015-12-09" version="1">MLTSSSSNGYHQFRNNTTPESEESIDMTTNGMRKEESFVNYDILLNNMDDSKREFATRLRRHLQFFFMDPMKKFQTRRQMPFKLALQVFKIVTITIQLILFAELRVSHVDFIEDTSTVMRHKFLQNWSDERDVVSYPPSAGRYSVFDSIDIFEHFAFATNAYYSIQNQTFASFSYDTSWKGISFYNSTITFQTPLYDIPPMSLCIEKIANVQINNNNYEFDVSPKRECNFLNYTTAEIIKLRENPQYMKDLLVKRNLTLTPEQSLSISKVLLMFNLRTIHYSPANKDQTPECYLIKVTISFDNTRHTGQVFIDLNSVISYEQICNGRVLKAPVISWDSIIVFVIDIIVLLFCFFSFILCLRALIKAHLLKETTMAFFEQNVGKKMPITDQMEFVNMWYLMIVVNDILIIFGTICKVTIEFRDFDNDLFTFTSIFLGSGALLVYVGLLRYLGFFNQYNVLVLTLKRSIPNILRFLVCAIILYGGFLIAGWVVIGPYSLKFRTLSKSSEALFSLLNGDDMFATFATINDSNSTIKVFGTVYIYVFVSLFIYVVLSLFIAIIMDAYEIIKERYKRSEKGETSVLKEFLSSAECVDASDPENRHLFSPDALLKLGGPLFHEREILYQIYEGLYNFGTRVKRRIWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDP6</accession>
    <name>A0A0N5BDP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BDP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000412900.1">
        <property type="protein sequence ID" value="SPAL_0000412900.1"/>
        <property type="gene ID" value="SPAL_0000412900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000412900.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7779" checksum="E99CE8EF806CACE0" modified="2015-12-09" version="1">XMIRCHFSKLVLKKLSELKYGALCYPPYSPDLFLTIFDLFDHLDVFFKDKLFKNQESAGSDFSDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDV0</accession>
    <name>A0A0N5BDV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDV0"/>
    <dbReference type="STRING" id="174720.A0A0N5BDV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000417800.1">
        <property type="protein sequence ID" value="SPAL_0000417800.1"/>
        <property type="gene ID" value="SPAL_0000417800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001349000.1">
        <property type="protein sequence ID" value="SPAL_0001349000.1"/>
        <property type="gene ID" value="SPAL_0001349000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000417800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001349000.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35179" checksum="930CE1EEDAB4B0F1" modified="2015-12-09" version="1">SVGLVVGEAFKLLLSVFFLTYELKSFPKAMKALYISTFVHWKDTLNTGIPAFLYAIQNLLFQYAISYLDATVLLVTQQLKILTTALFAVLILKSKLSGVQWISMVVLIIGIILIQWKVPESKKSDSVVGNGTEIAKVVKEDFYPLPNPLHIPPQIIGLVMVFIGTILSGFSGIFLEKIFKKTSQSIWCLNFQLAAFSVPVFFCVSVITDSSKIDEKGLFAGFDWWVIAVYFLYGLHGMVVALLLKHASSILKCFASGFVIASTAIVSIFLFNIIPNLLLIFGTSIILLAVYLYSSFPYKKKSDITLPQKCDNSSLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDZ0</accession>
    <name>A0A0N5BDZ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000421800.1">
        <property type="protein sequence ID" value="SPAL_0000421800.1"/>
        <property type="gene ID" value="SPAL_0000421800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000421800.1"/>
        </source>
    </evidence>
    <sequence length="865" mass="98950" checksum="BBCB579D9D372B1C" modified="2015-12-09" version="1">MKPDDIGITKLTKRYRECNLCGKQYNLNTSSNTIYIHACRHKQFHDILRRELGEAKFQEKLNNLPKNFRFEDYVSEDSNKTDTSNQLKSPTEDSSGSSGSVTRKRKLLDHTIVGTPKDLVPSLPVTRNMSTRLSENLASKTNSDTQSKDNYLKDISLDSKRINVDKIKCSVDDAPGISDYLPDGFRKVIKTDVLGLTKLISINHRICLGCNRKFQSSCGVTSLYKHCIRHPEHRAILKKNLATTAYINALKNAHIPYTEDDIKDEHGHLMIAAEESPFFTSNQSLSDLLEKAKSYDCLNKSSNSTIVENNDIVNVLTDGTSTLKNLIMQPIENQILETPVKKPSYSNKEFKSLLHKFLKTSGLSLESLERDGFSQLSSLFRYKNVNQLVKEIIDTNELKKCVDRKILENIENYTISIEEYTNNDNIAAIIKIYYLDIDSRFISQNLGIISFKDDMEVNEFEKIYNRITVMLEKFKLKLTHATPLVSRGTIFSRRFSVRSGISEIPCLRHEIIKCILHIQSTSSKIFSVLRKASKKFSLYKYVVDNEMEVSSKLKEIKGVKAPTGWVDIYNILAFGALNITEAIVFCQEFWPSFVLTNEELEVVYRFITISQPVIEALNLLTSDSMNLTSYLKTIVDISSKYDNYEILPVKGDLTKLLQTSNAVSINNSSKLNEYTHLEAFEISCEPVSIDLTNEDILDLFSSLKSKLCEEFLDLTNKSKENALICKALLLNTEEAYNPKYGDISFWTSIESLFSSSFSNFDNDTSKNRISFDDGNITSAHLYRNLLYNYDSEYLNEFWPSQKNVLPLMYSEYIKALSIPVKQNRLNKSESLFDWIKSSNYRNDDVSSDMYFTPNDNYCQEIIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE09</accession>
    <name>A0A0N5BE09_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="4">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE09"/>
    <dbReference type="STRING" id="174720.A0A0N5BE09"/>
    <dbReference type="WBParaSite" id="SPAL_0000423600.1">
        <property type="protein sequence ID" value="SPAL_0000423600.1"/>
        <property type="gene ID" value="SPAL_0000423600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.240:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058549">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="B12-binding" evidence="11">
        <location>
            <begin position="604"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000423600.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="80971" checksum="04D2F5E5F47F820D" modified="2015-12-09" version="1">MLRLNKSIFSKNILHFSRTCSTPVSLDPQWSEMARKQLKGKDPESLIWHTIEGIDIKPLYTINDRKSDFSSNIKELPGQFPYTRGPYPTMYTQRPWTIRQYAGFSTVEESNKFYKENIAAGQQGVSVAFDLPTHRGYDSDNPRVSGDVGMAGVAVDSVEDMKALFDGIPLDKISVSMTMNGAVIPVLAMYIVAGEEQGVDQKLLAGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIFAYTAKHMPKFNSISISGYHMQEAGADAALEMAFTIADGLQYCQTGLDAGLNIDQFAPRLSFFWGISMNFYMEIAKMRAARRLWATLVKERFNPKNPRSTMLRTHSQTSGWSLTAQDPYNNVIRTTIEAMASIFGGTQSLHTNAFDEAVCLPTRHSARIARNTQIILQEETGICKVADPWGGSYMMESLTDQLYNKAYNIIKEIDEMGGMAKAVASGMPKLKIEEAAAKKQAKIDRGDEVIVGVNKYKLEKEDPIEILQIDNNKVRSQQCAKLKHIRETRDKARAEAAIQRITDCCKNGGNLMEAAVEAARARVSVGEMSDAMESVFSRYAATNRMVSGAYISSFGQSREIEAVVHRVSKFAEKEGRQPRIMVAKLGQDGHDRGAKIVATGFADLGFDVDVGPLFQTPREAAQQAIDADVHVVGASSLAAGHLTLVPQLVQELKKLGREDIMVITGGVIPPQDYDALYKSGVSCVFGPGTRLPDCANEILDKLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEC7</accession>
    <name>A0A0N5BEC7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEC7"/>
    <dbReference type="STRING" id="174720.A0A0N5BEC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000435000.1">
        <property type="protein sequence ID" value="SPAL_0000435000.1"/>
        <property type="gene ID" value="SPAL_0000435000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="29"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000435000.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45824" checksum="E285861DBC4A645F" modified="2015-12-09" version="1">MSLFNDVPVAPPIEVFFMNKKCQDDVDPNKVNLTIGAYRTEEGKPLVLPVVHEAEKRILADASLNHEYLPVLGHEGFCNAAAELVLGSNSIAIKEGRYFGVQCLSGTGSLRIGAEALHDMIGLDTVYVSNPTWGNHNAVFKKGNFKNINKYHYWDTENRKIDIDNMLKDLENAPEKAVIVFHGCAHNPTGMDPTHEQWEKIAEVVKRKNLFPFFDIAYQGFASGDPDADAWAIRYFVDQGLEMVISQSFAKNFGLYNERIGNLTVVVKDPKVITGMKSQISLIIRANWSNPPAHGARIVHMVLTNPDLKAKWFESIREMSGRIKEMRAALRKHLEDLGTPGKWDHITQQIGMFSYTGLNPAQVKHLVEKHHVFLLSDGRINICGLNTKNVEYVAKAMDETVRNISNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BED0</accession>
    <name>A0A0N5BED0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polo kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BED0"/>
    <dbReference type="STRING" id="174720.A0A0N5BED0"/>
    <dbReference type="WBParaSite" id="SPAL_0000435300.1">
        <property type="protein sequence ID" value="SPAL_0000435300.1"/>
        <property type="gene ID" value="SPAL_0000435300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF93">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLO box" evidence="1">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000435300.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35173" checksum="8F44A0DBF7689909" modified="2015-12-09" version="1">MEGCVDFSGGNYGIENTLQKGFRVVRHFLGSRIVEKIEIDNTSGNKNVPEEELKIDIEGKSIFLSKGVCRFVDHLFKNGPKRISSWEMGRNAMSCSRRPKHYISRWIDFNEKFGLGYQLSDSSVGVNFKDNSRLVVDGSMENYQYIDKNGARVCFDYDKCPTNLGKRCKLLEYFKNYMENNLLAEPPAEEHENIEIVDTGTPILLKWKRNDKCICFILLNGVFQINFLEDHTKFIISIPTSSISIIDKDNKLKTYCLEGLINGGVDAFTEEKMFYIKKVIDEWTSLKRRHEGNDDVVVAKKSNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEQ5</accession>
    <name>A0A0N5BEQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid-sensing ion channel 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEQ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BEQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000447800.1">
        <property type="protein sequence ID" value="SPAL_0000447800.1"/>
        <property type="gene ID" value="SPAL_0000447800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000447800.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36226" checksum="CB0B7F51BE1F2934" modified="2015-12-09" version="1">MAISNYDDHGIGRCFIFENKKQKFGAFSRVGKEFGLSVLLKNEISDIKNHFRKVYGYPPYLSIQYQILNPKDKDNHQLATFHTDVLPLGYEVNIPITIAKEIKNKNISNCLDYNTEDPDSLYTFGTYTYDSCYTTCLKKNHLTQCQNIIPFQPNLLMCGKEKPCKCDDLKCFDCLSDSLFPDNLNNDILHPEFKDKCSCPPPCESYSYRTNPTYSKLHAKNMAEMLRLTGSEEDLEDDISANYVILNFFIKEHTVLTKKEEVVYRSANLFADIGNTLGLLLGLGMINIIEIFFCLFLIIIDRIQYFIKFRRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFH2</accession>
    <name>A0A0N5BFH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFH2"/>
    <dbReference type="STRING" id="174720.A0A0N5BFH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000473800.1">
        <property type="protein sequence ID" value="SPAL_0000473800.1"/>
        <property type="gene ID" value="SPAL_0000473800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF243">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000473800.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49179" checksum="06303254EFC5F0C5" modified="2015-12-09" version="1">MYRKEISRKVEENKSLNSVIDTQKKKVNIKLPNMSSQSTSRSSNSSHLTESKNEIQAINTSSSNNPSEPSTTRKTISKENSVEKRRARLNMPLLYRMYESQSEDIRGTISGPETPDFHPEEVAKTLRNALGGITTDDKTIISAIFLHTNFQRQMICKAYESMYEKNLISDIEEETGGFFMDLCIALLRPTHVFSTQLLIESISLKNQDINITVEIACTSTNSQLRVIKETYTSTTNRNLERDIVNKIEGVCGKYIQALFSKTRDDDDTINGEIIKENLNIIAQSSNFFDDLGRNPDLFTKLFVTPSFPSIREMIDTYDGKKDPGKDFESMLRKNKIIHAEIRNIILTIIKISRSTQIYFADKLHEAISGARADHLTIIRIVVMRSETDLADIVEEYSKKYGHSPLHWLQKTCSGDYYRLLSAMLTINTVNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGI1</accession>
    <name>A0A0N5BGI1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGI1"/>
    <dbReference type="STRING" id="174720.A0A0N5BGI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000508700.1">
        <property type="protein sequence ID" value="SPAL_0000508700.1"/>
        <property type="gene ID" value="SPAL_0000508700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF54">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894323" description="Sphingomyelin phosphodiesterase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="16">
        <location>
            <begin position="52"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="565"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000508700.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="68805" checksum="662CE60CD448EFF7" modified="2015-12-09" version="1">MKSYLFFILIFEIFCHQVYSSVISRNPKEFNEIQEKIVRDADELMKNNYSKNKFRCKACHLLVDLAQKMIAYGKTVEEIEEGVIKLCEKLNVENNYVCNHTVHQFSPEFVYVLVRTIVTPQEICGAFIADCGTAENPLNNLWPFKIPDNKPPVKPWPIVKKPQSKLRVLHLTDIHLDRDYKVGSVANCNIGKLFESFTFCCRAYPNIDKKRQRDNNKTIPAGYWGSPYDCDIPFRTFINAMEHLSKNDKFDYIIVTGDLEAHDIWDYTRVKTMTNILNISAVLNEYFPNTPIYQATGNHEGVPMDSMGSHTMSEYNNFGPSWLYKTFARAWKRDLPPSTQNDIKFRASYSVKPYSGLKIISLNTVYCSIMNLYNLLNQTDPDGTLEWLSKELLDSESKGEKVHIITHIPPGIPYCLKGWSFNFYRLVNRFENTIAFLGMGHTHQDHFEVYYDNDSSTGRPTNINWIAPSLTTFSFNNPAYRVYEFDGNYQGSTFTVLEAETYYTNISEATQTNPPVWKLEYKFTQEYGMPDLSPKSFNDLIVRLEKNETLFNMYHLNYYRNYRKCDEKCKEDFICSMKSARSFHSKSFCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGL8</accession>
    <name>A0A0N5BGL8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGL8"/>
    <dbReference type="WBParaSite" id="SPAL_0000511900.1">
        <property type="protein sequence ID" value="SPAL_0000511900.1"/>
        <property type="gene ID" value="SPAL_0000511900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000511900.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="35070" checksum="FFBB5E72FCB655C5" modified="2015-12-09" version="1">MLESTKKNIFYIVTCTYLPNLGQEQADPATSSFQISQSYNLTDLQELKSTLQYYGSFDLTKTKFLVVDWDEIKSLKNESLPVVYINVFYPENTITNDINSKKRISRWRLECSLSKCTFGLKFIFNNTHYSDLSEYNSNINPDYSFMIMFMVKTNKISLKTLSYGGHNYPLFYCPTKYWFTSESNIIFKPHKSIENTKNFIAKQSKEILLPIYPQTINAEFFICGMIKQPMLSDIEIGYDIKYTSEKSIEIIKNDNKAYEICKIDKIDDVHFTFAFMDFEFNYDNKRRFIKKSKEVKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI34</accession>
    <name>A0A0N5BI34_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibulin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI34"/>
    <dbReference type="STRING" id="174720.A0A0N5BI34"/>
    <dbReference type="WBParaSite" id="SPAL_0000561800.2">
        <property type="protein sequence ID" value="SPAL_0000561800.2"/>
        <property type="gene ID" value="SPAL_0000561800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000017">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017048">
        <property type="entry name" value="Fibulin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF27">
        <property type="entry name" value="FIBRILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036313">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01177">
        <property type="entry name" value="ANAPHYLATOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894296" description="Fibulin-1" evidence="13">
        <location>
            <begin position="23"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="485"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000561800.2"/>
        </source>
    </evidence>
    <sequence length="909" mass="101513" checksum="DF6F993A51C8F200" modified="2015-12-09" version="1">MFSIIFGGLLLLFLQSLTLIYGSELTRCCAGGSRHYKETNSCHGLRSEGSSIACSRTASICCLRAMMDNSCILGLKNAQEFEYCSIDKNELGAPLKKECCDCCLLAKDIVERGEDCLAPIGFSTPCLSSFNKCCGNSTNTNNFEKKFQKEETKINKISKGNQKDRCKNAKCEHFCNDRRGEDVECSCKPGYDLAPDGYSCIDMIESLNKRDFPLSNYKYGKREHAYNNCPIGFISNPVGKCVDINECDTLFHICYLPNMQCLNVPGSFSCVCLPGYYWSDVGSTCLDIDECLLLLDNCLESQRCLNVPGSFKCIRTLSCGTGYALDSETELCMDVDECNLGSHDCGAMYTCRNIQGSYRCDPKKCASDEVMNPKTGECVSITCPFGYLATDGKCQDINECLTPGVCKQFEECINTPGSYRCQEVGNLCEPGTRMDKATGFCQDIDECLEGTHTCGSQECINTVGSYKCICKAGYEFNKTSLQCEDINECEKFKGHVCSLHAVCENTIGSFKCHCNPGYESAGDGKNCVDVDECALGIGNCQQRCINTPGSYQCVCDRGYQLKSDNTTCEDIDECASYENTGNELCMGECINTIGSFKCSCPPGYQVMEDGIVCKDIDECAEKKCPKDNICVNTLGSYKCHKIKCPRNYYHDKQNKNRCLRSSDACRGLSTSQCKKIPLHITWQYMAIPKHVNISSSRTSIILFSLKGPSNSNNHVQYELNVKEVLTDKEHVIPAVRSNFLIQKGNHINSAVVSLRDSLDGPQEIHLEMVLRLSINGNFQQIHVEEGYSCLKKCYPTDVACKVNTTLEILYQFRSIPTIRYIPMYGLEVARIGSRFLPPYTVEYILEPQNLSYFKVEQHNFWGILKLIKPINGPQQIEIKIHIYAKSRSQILMGHTIAIINLNIDNYRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI42</accession>
    <name>A0A0N5BI42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI42"/>
    <dbReference type="STRING" id="174720.A0A0N5BI42"/>
    <dbReference type="WBParaSite" id="SPAL_0000562600.1">
        <property type="protein sequence ID" value="SPAL_0000562600.1"/>
        <property type="gene ID" value="SPAL_0000562600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000562600.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11353" checksum="1863D572B9E28699" modified="2015-12-09" version="1">MISIFDVASRFHQIPLKEKSRFLTAFNSPWSVNKFTTTLMGLSGSPGTFQRVMDFIFRDIKYRLLIYIDDIIIFSNDEEEHIKTVSEFLHYIVNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIH2</accession>
    <name>A0A0N5BIH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BIH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000575600.1">
        <property type="protein sequence ID" value="SPAL_0000575600.1"/>
        <property type="gene ID" value="SPAL_0000575600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000575600.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25710" checksum="E77B86A8A1989912" modified="2015-12-09" version="1">XIFTNAPETNQEGKPKEYILSTADRFTNESYTNTTLSGRQNLLQFIKEKLKPTPTDGTSTSKEFATLKVGTIVYKKIVNAHKNNEQFHGPYRILEHLHGDTYLIGMVTRSNRKTEQIECCNARFLKLAPLAIQNTLNDASHILDNDNHQNTRVTSFPQETIIKKGKGRPRKVLPTNNETPNTDEIIIQPKKGRGRPKKLVSINNSNITTIDPQTQQPIRGRGRPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIX2</accession>
    <name>A0A0N5BIX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIX2"/>
    <dbReference type="STRING" id="174720.A0A0N5BIX2"/>
    <dbReference type="WBParaSite" id="SPAL_0000590200.1">
        <property type="protein sequence ID" value="SPAL_0000590200.1"/>
        <property type="gene ID" value="SPAL_0000590200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF59">
        <property type="entry name" value="CUTICLIN-LIKE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894321" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000590200.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27361" checksum="E58FECA5C36F2D96" modified="2015-12-09" version="1">MRSAGGVFFIFLCYLMEIGFGDYTKLINTEIHVVLEPLKYILPRNMTPSDINCKFTIHKESCKNPSMSEFDTIFWHTTVCLKWKCNEPKLTIKVNKCWTGSLHNPIFIIGPDGCTVEGSMVKSPLYNLINLNEAQSYGRLSVRLYGKNYIHLGCSISFCHICDKVCIDRSQPICDDHKSDEELKNRRVWSQLPHVLNYCDPVKDEHFLELLTSSTSRKSLLTIIFISIIYIINNNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ07</accession>
    <name>A0A0N5BJ07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate sulfotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ07"/>
    <dbReference type="WBParaSite" id="SPAL_0000593500.1">
        <property type="protein sequence ID" value="SPAL_0000593500.1"/>
        <property type="gene ID" value="SPAL_0000593500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000593500.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="27609" checksum="AAF13E91B8706452" modified="2015-12-09" version="1">MKGKDYLLKYQFSDCGRSKRYISATKMALTNKFKKADELFKEWNVLMIVRNPIDRLISGFMQLCYYRTWLKKNEDYCYHCNKNITCFVDRLYNELVNVANKEKIPNQFNDYHFYPQTWQCEYYKYKKNYNYLKYPSKDKNIFYGNLMKELKKSGVALEHINFLSNKVKTFNTFHTTTGKKDTKNYKESLFKNTKLIRKICSIFYYDFIEFGFEFPKACEGIPVLVNNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ23</accession>
    <name>A0A0N5BJ23_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ23"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ23"/>
    <dbReference type="WBParaSite" id="SPAL_0000594900.1">
        <property type="protein sequence ID" value="SPAL_0000594900.1"/>
        <property type="gene ID" value="SPAL_0000594900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000594900.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="49045" checksum="396354D6DCFD2AEF" modified="2015-12-09" version="1">MNRFRKSDIFTDVTLCNSIRAHKCFLAAKSKYFEKLFTNESNKNKDKFDFPNISDDAMNIVVDFIYTDEINVDKNNAEEVLIAAGEIQIEELINYCQDICNKQIDKSKRLRSENIISKNYKELYLFGGLSWSRNEGYITAPTEIYNLNESSRKNKEQYLTTIDNKRTLNRFGNALAKFGNTVYAIGGQNHDEILNTIESIEINSLTSFWKKTTANFCFNSKYLESVTIDDKVYLFGVNSNDYRNKNFHKMFYCLDLNSLTMNPLSSFPINLYTPSPAAVDKTIYVVSDDIDNSVQTSWIRKKSISEEGSTFFRIDTRLKDWESLPSTKYRKFEGCMISSNNMLYCVGGGYPHTCEIFDIRGNRWKEMANATSASYYSKLVLLDGKIHKIGHSCFNEMYEPTIDEWIKTERIRYPRFGFNTTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKW9</accession>
    <name>A0A0N5BKW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKW9"/>
    <dbReference type="WBParaSite" id="SPAL_0000657200.1">
        <property type="protein sequence ID" value="SPAL_0000657200.1"/>
        <property type="gene ID" value="SPAL_0000657200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="86"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000657200.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26061" checksum="6667E8A29907A109" modified="2015-12-09" version="1">MISKELYAGSILSNNKFDKLVNNSKGESIEDLTKYVHSKDYNQKKLPLSRSISVRRQPNSRRSSSLFSRRHSLAHATIQLKYRLIEELNRYIEIHKMQPLLKDITLYKKAQKHAKNLAITRSLRRDNNIRTGLLMGIVYYSAASVMVKKWYDEGYKYDYSQINGRPGFQGFTQLIWKETRYVGIGIATNKFQVWIVFKFFPKSNINGRYRSNINRPSKHCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLU7</accession>
    <name>A0A0N5BLU7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLU7"/>
    <dbReference type="STRING" id="174720.A0A0N5BLU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000689300.1">
        <property type="protein sequence ID" value="SPAL_0000689300.1"/>
        <property type="gene ID" value="SPAL_0000689300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="6">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000689300.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16279" checksum="F09D920DBB0B775B" modified="2015-12-09" version="1">MGRLFIEHLGGKRMYVCKKCNTYLTNKEQMISSRFTGSTGRAYLFDKVVNLEYSEMQARNMITGDHFVRDVSCKVCKTKIGWMYEFAFEESQQYKENHVILEKKLIKEEKGFDDPLNGGDGNEVHQTITSTESNSSTSSSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMD4</accession>
    <name>A0A0N5BMD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G2/mitotic-specific cyclin-B3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMD4"/>
    <dbReference type="STRING" id="174720.A0A0N5BMD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000707500.1">
        <property type="protein sequence ID" value="SPAL_0000707500.1"/>
        <property type="gene ID" value="SPAL_0000707500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="239"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000707500.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54255" checksum="810E239AFE61F5DF" modified="2015-12-09" version="1">MNFTKKPHSNQLPTQHSLTNASLIKIPTLNNIPRQVLGEIKDSKLNKGQSFNNVSAQQSQPLKRLSQHNYNHIPSKSSMNRSFEAYCDDFDDEETRLGFPENSKAAASKLQMLSSQNTNTSGYISENDVSFSSVDASKTSFSSMDISFGNNGFDTTASSIAAKEEKDKEIVLENSSPDDILKPSGLFLPSVAEEITIVEEFKKDIWMYERYRGRNTSLPHRFLDHQRDLNNECRSTLVEFMIEISNEFNLSNQTLHTGVELMDRYTSKHQCPKSIYQLVGMTSLFISNKLHEVDAVFLRDFVYACDGAFTEEQFFEMERNIFYKLSFTINIPTVNFFVDFIENFIKRGEVYSQLLSMVMDLCLINDFLSSGDRAETAAACIAYANAVLNYPIWCEDLRTITEINGHQFKEKLYFIAMDIKNFKKRSENPHLLGVQSKPGDYLIRKYKDDNLCSVLDYDVPIKVIQDFSKNHNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH6</accession>
    <name>A0A0N5BMH6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rep_fac-A_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH6"/>
    <dbReference type="WBParaSite" id="SPAL_0000711600.1">
        <property type="protein sequence ID" value="SPAL_0000711600.1"/>
        <property type="gene ID" value="SPAL_0000711600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor A C-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711600.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19707" checksum="51CC3E162982141D" modified="2015-12-09" version="1">MIQEEEARHQRQQEEADPNNGIIKVRNIDEAKEVIALRRGNVHFELRGRLVSVKPGMTYQACLKEFCRKKVSWENGFYQCSKCGAQSTRFYNALLVVLEILNNTDRHSIVAFDDVARRFLGRDGQTVAAFEGKYGEKLARDEVVERFLGRGYTFVINATCLTRWILSTATPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH9</accession>
    <name>A0A0N5BMH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000711825.1">
        <property type="protein sequence ID" value="SPAL_0000711825.1"/>
        <property type="gene ID" value="SPAL_0000711825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711825.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7636" checksum="82DDF341C98A0EB7" modified="2015-12-09" version="1">MNYNSYSFSKNGEPTMLPYNPLYQMTMGSKSEATFLNIMVLNLYYCEDICLNRISCKNNGYQNPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ50</accession>
    <name>A0A0N5BQ50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ50"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ50"/>
    <dbReference type="WBParaSite" id="SPAL_0000802050.1">
        <property type="protein sequence ID" value="SPAL_0000802050.1"/>
        <property type="gene ID" value="SPAL_0000802050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000802050.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11362" checksum="C5E46459BDFF76D4" modified="2015-12-09" version="1">MWKSAQPPVKKQINFTTKIHDWKDRHERDGLTGFAKMVPRNSIIYRAICTYKAQNIGELDLEPNDIIFVVELLPDDYAVGVLLRNGEFGVVPLEKIAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQY7</accession>
    <name>A0A0N5BQY7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQY7"/>
    <dbReference type="STRING" id="174720.A0A0N5BQY7"/>
    <dbReference type="WBParaSite" id="SPAL_0000829400.1">
        <property type="protein sequence ID" value="SPAL_0000829400.1"/>
        <property type="gene ID" value="SPAL_0000829400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000829400.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35915" checksum="E2D385469DD66930" modified="2015-12-09" version="1">MERIPYLSNFMSEKGCIIPENFQSSKILDIKNMKKMCKTFNKGVIEYKKSQSFCIEVPSPISMANYEFIENYIYCKIFKRIRNFNKNKPGFSDTVYGEILNKGVQRILEKFCLKNNDTLFDMGSGIGLLLLQASATTNVGKVVGIELVKEEYDFSVQLKDVFMHVMKFGNFKFQENIEFINGNFFENDNVTKICSEASAVFIHDISFQPDTLNRIRSDIFYNLRNQVKLITVQDHYGRFRLTPSKIYSIEAILTNRDKINIGRHLSYCSKEQFLHYYEINRTQLNQYKEKLRIVDERRRTRNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR33</accession>
    <name>A0A0N5BR33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000833700.1">
        <property type="protein sequence ID" value="SPAL_0000833700.1"/>
        <property type="gene ID" value="SPAL_0000833700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000833700.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58596" checksum="7AFB881A46C65952" modified="2015-12-09" version="1">XLDYTIGEVKKSVNGTKDEPKKYKNETVVKEVFLFKLPLPDNFDEFGNPGSTEIKFFYNEQEISEIRLPEVSSKNFVLKEANVNVTSCSLKNCAMGALFYKNISGALPGPPDFPKFHKIFYVAYEATEKYKFLFLKFLGNFNHKDKLNVIACPHETWISEHSLLEYIADKNNIIPFPEKNESDKYYYYYKLNHYQNTSSEIALKCGHIKQRNMPPIDVGYACCSKQKSELGLRSLIFPNYLNKKSLTIDSNNVLSDDEHGSLLNSSLIAYYILSPDNNFNSNSIVFGRYNSNSKLYSGQSVLALDKDDYKIFSILINSGDNENTYYFHSQFLVPNIKATLRLKVNGVVQEFKTAKNSESMDTYTVDLGGMNNGLVGCHAVPDNITHPGFKDFYEKRYRTELFVIDKSTNMSIKINDTKSFVENSTYKCALYNGTTNYKNLTEKYIKETEFKIHIIKSSNLEGSNDSNKSTDSTKSKSTIWIIVGVSVGAVLIITLLLLAGLIFYKKRLLKKKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRH7</accession>
    <name>A0A0N5BRH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TNFR-Cys domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRH7"/>
    <dbReference type="WBParaSite" id="SPAL_0000847600.1">
        <property type="protein sequence ID" value="SPAL_0000847600.1"/>
        <property type="gene ID" value="SPAL_0000847600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894843" evidence="6">
        <location>
            <begin position="27"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7 9">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000847600.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="53491" checksum="CBC97BDCB8EDA208" modified="2015-12-09" version="1">MGCFDILSKLLVVLCCYILFHAYVHGYKFNVNYCIDKVEGDKEIDESNIKTGLEMISKRSCINFLYNGTCYMKKTNCGTECTAGCGKWKYANDKKCKECFDPYKKCNENCKKCTNRCEDWKKGNVKECKKSNSKSKECKVKYEECKKIKYKSKECRAKYEECKKCKITCEECEKNISLNKEEVYNMEIDMNCNKKPGCIAKKVLMYLGLIPTVRRRDRDYYIKVNDDNIEFKYKKHYSELKNIALDFIGYDYSSIAHFGDSYGALTNTKTFIRKQLNDERVKLTGQEVRPAFLDLKWLHNTYCKGHFRSFVQCKNSGFSKSYETNRCECPTGYTGRTCEDLQYQNRKLCPGPVIYVDEDSGKQELKFKAKTNCTVRLYAPVGRRIRIHIEKTYCTNKDPCFENDCLQIKYHTDMANTGLCVCGKFENSSLTTKGTSALVQYTGKRTNYYAYLSYHLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRP2</accession>
    <name>A0A0N5BRP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NPCBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000853700.1">
        <property type="protein sequence ID" value="SPAL_0000853700.1"/>
        <property type="gene ID" value="SPAL_0000853700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000853700.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="33473" checksum="CF38F4998B9B9085" modified="2015-12-09" version="1">MEHLDRQNVVKLRVTFIDEEVKFLRYTFKMADCCDLESQWINYFPKNKEEYNHFLKEKDFTGIQELEFFKHRIGESVKLLEIRPDDIEFDGYFFKIYERVENICDDMGDFEPVGRSITINMWSNPGLEISHYDSYLKSNFFKEHGFFGENGLELITVKFILDRLTGNPDLKYKNISTDSERPLNIKVSECLFNDGYFNLENRCSSKKITIVFSKVYLFFTVIERDFYKEIFEEIKFRNNLVEIVDNGEEFRIETGMDCKSCQTKHLNRVVYSGDDITLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS71</accession>
    <name>A0A0N5BS71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS71"/>
    <dbReference type="WBParaSite" id="SPAL_0000871650.1">
        <property type="protein sequence ID" value="SPAL_0000871650.1"/>
        <property type="gene ID" value="SPAL_0000871650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894781" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000871650.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9149" checksum="5B5C7525C8591906" modified="2015-12-09" version="1">MNFIKSIKTNIFIFLIISTLCFQLIENTPEKVEDLTRVRRGMPFDATLRLGEKLVNLTGRGDHDPSSKHGGTGPNSYGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU49</accession>
    <name>A0A0N5BU49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU49"/>
    <dbReference type="STRING" id="174720.A0A0N5BU49"/>
    <dbReference type="WBParaSite" id="SPAL_0000937200.1">
        <property type="protein sequence ID" value="SPAL_0000937200.1"/>
        <property type="gene ID" value="SPAL_0000937200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000937200.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="67874" checksum="5E4196DB80123DA8" modified="2015-12-09" version="1">KMAPMNHIFYMDDLKFYAENGKDLKDMFITTKKIGKELGLDMNTSKSAKIQNVDDDLLLNETKRHADNVDELELEFIPEVKNTYAYLGIDQKSLDNSKVSIMRIAEKIDKLNHELFNSDLAVKQKVQGYNSISIPVLNYIANNMLGNTKFESTLNQIKKVFKDKLIKCLYKAKIRQQNNLRECIFLPHEKGGLRIKDPVFEYKFSHVTTALYLIFRPDLRGITQNLLSWTINRRRTIFKDMMHILNEMFPGLTIKDIKINYLDDGKTKMRFKDYTWEDMDTALEDVKHLLLNHHYECILNDISTKNTWGRLQKNMLDIQYPIFKSNIKNEMMRTYFAISENQVLLRSHPTNAKKGKSNVCRMCKQYPETLTHVLTSCDKILSTFGKERHDFVTRIIWRELIKKFNFKYVPGLKLYENEDYKLLWDYKHEIEEKLHHTKPDTTIIDKKKNGVTLIEAAISMTELMTTQKRIKEIRYTMNGEIEITHENYKNIIHANNLKDVLLRNGYYDKHTNTKESIGHPFRVCIRTENHDQANFCPFTLQEVSVLFEFALGHLRYSLIDVPSQSNSPPDMVIDVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUE8</accession>
    <name>A0A0N5BUE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUE8"/>
    <dbReference type="STRING" id="174720.A0A0N5BUE8"/>
    <dbReference type="WBParaSite" id="SPAL_0000946900.1">
        <property type="protein sequence ID" value="SPAL_0000946900.1"/>
        <property type="gene ID" value="SPAL_0000946900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF300">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ephrin RBD" evidence="7">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000946900.1"/>
        </source>
    </evidence>
    <sequence length="876" mass="103271" checksum="11FFE633CE57A65D" modified="2015-12-09" version="1">MNGNKNNDDNYQEYISKKNYDINRNDKVNYFLFEWYSKNPKLHATINKSHLEFENFTDKKNYLTIKINASTIFRFTCPGSRIYDKLGVKKNSDNDQSNYLYENTKIYNVSKRSFLRCELSSTSKFIGECTRNNYKKYFDFIANKHNTNFTNDYYFITTSSGYLSGLHNKKNGLCRTKNLRLNLKILKESNLNDISKYGKEDNEGKNLKLNNYTLNRQQSEEVDHDVIDFKQTEKKGTMYLKINYSDDLFKMLEEYNNHHMNLNAKQFENNGIQLSPTSNEDDIITSEEYDLLFNEASDVLSDVDRKNIQIFKEKQYKKFEKEKQIEDPIDDLKLYESFRLHKNGYILSDKDDNESSEYYGNKEGKHINHLMKEKHFMTMEKIISNKTYPKFGQLTSTYDRVRIFDSPFAYLVINKEVNRYCSYCLQPPIYGKKLMRCGACEFACYCNKECQKLAWKTHRGECRRLKAVFPNLPLTEVLFLSRIIDKVLFIERHGDHFGWERHRKFSDLMAHKEDIINDEPKMEHFKKLLKKMDTYRKEEMISEEKFFDIFCRATINSHSVHTNAGTEIGIALDLGVSIYDHSCRPNCSLVFEGFKVCLRPLTQSANPYDRNCAYISYVDVGRSRYRRQIELKKKWYFDCRCERCIDPNDDILTSLKCRNKECDEPIVTHELDKVRDIECPKCKTICKSEDVKKGQELMKILPSSVDPSLKIDEIQNFLDEAKTILHDKNIYVSRLMTAVLHMNGTLQGNIEFIQKQVYENYKMCFPSMDRHNGFQLLHIVKSLIEQGKRQEAIPYAFDAMTIFEVCFGMQHPYYLQTLALWTFLEKNINKTDEELYVLMNFNSNTSIDISQYVADIKLDPNDATKVTSQNESIKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUK2</accession>
    <name>A0A0N5BUK2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein C6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUK2"/>
    <dbReference type="WBParaSite" id="SPAL_0000952300.1">
        <property type="protein sequence ID" value="SPAL_0000952300.1"/>
        <property type="gene ID" value="SPAL_0000952300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000952300.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10237" checksum="A63184C577B962D4" modified="2015-12-09" version="1">MTLMNSFYVGASPAYQALGLHNGFAGYPTSDSRVASRGSQLSGGPPQHFPSAASRHLASEPQMATAISSQFVESFYAGAQPQHNHFGYDGFAGYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUY2</accession>
    <name>A0A0N5BUY2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUY2"/>
    <dbReference type="WBParaSite" id="SPAL_0000965000.1">
        <property type="protein sequence ID" value="SPAL_0000965000.1"/>
        <property type="gene ID" value="SPAL_0000965000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000965000.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67379" checksum="8E43820C188696E9" modified="2015-12-09" version="1">MSTKEIFESEENKLLEEGNNGGSVTATTTSASSITTDNIIDDDAVALLEGDYDNETNKETKNGTTSTYSSSFFNYDEEFELDYSEDELLRDDEPVVTSTKNDPKKQDSISEMKETDKAKESSESVTTSKETGNNKSEIPIDDDKKSSESKEGKAANGKRNPITFGGGSKKTNKHHSNKKRNFDKGPRYDKSKVILRTSFVGPNNCQPIQQRMMVNNQNFQNPRRFNGPQMVNNSSFNGFPNVNPFGPAAGQQSAIMGMNQRSGIPPTGIMGNNPFGPNPGMAFPSKTMMSGINYGQPRSMMPTMAAAAAPPMTGINMMGYQYSGQMLPQGIYTGGVVMNPTMQIDWSKLADEFSGAAERGIRSRRRSRHSSCSSYSSSDGSRRSRSSRDSSSDSQRRHRKRKSSRKDRKSRKRDSRRRSRSYSSDRKRKDDHRRKDRSRSEERKRRDKNNKKSNPTLECAKIVGVDKDYLRKVEQQQKLREEVLRKKRNNEKIDPKELKIEEVNPENVLKAYLVVSIEPSPKTEAWSFGNPKEKLTVIAKTVGKVKKVWKKGEKMICIIFESHNDATKFSHTYDGKTVNGTKLDVRLDKCRLILSKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV26</accession>
    <name>A0A0N5BV26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV26"/>
    <dbReference type="STRING" id="174720.A0A0N5BV26"/>
    <dbReference type="WBParaSite" id="SPAL_0000969300.1">
        <property type="protein sequence ID" value="SPAL_0000969300.1"/>
        <property type="gene ID" value="SPAL_0000969300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="305"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000969300.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47605" checksum="0DA76895874A2675" modified="2015-12-09" version="1">MDCKELETSNTGIKEQCDQLEGKTCSDKVSEHEVVPRKIPCLNSEITEDIKSIVPESPSNSPQLKCQTDGKVVDMTTKEASIDGDENNSSNSDDTSKSSPIIDAEHVKESDRSSEACEKLAKDIIDKGVDEILAEFYTLNHGIEDADLELFFNFVNMSRNRYRDIILKDTTRIILEDEENDYIHANYVSTPSNSKRFICCQAPLEQTTEHFWKMVLQEGSEYIFMLCHIVEDGLQKCHPYYPDEVGGKLVVNKLTIENSELEEHPAEHGLKVSVLKIYEDGVLKKTVKHWQYVSWPDRKVPLLSETIFYALDNMRVSDKPIIVHCSAGIGRTGTVVFLENLLEKINNGDIMKETPANVLEGIRKQRVMSVQTPMQYLYTHRLLLNHLLKERKIRETPELQRFFREYDEEYDKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV73</accession>
    <name>A0A0N5BV73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV73"/>
    <dbReference type="WBParaSite" id="SPAL_0000973800.1">
        <property type="protein sequence ID" value="SPAL_0000973800.1"/>
        <property type="gene ID" value="SPAL_0000973800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894899" evidence="1">
        <location>
            <begin position="21"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7381" evidence="3">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="238"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7381" evidence="3">
        <location>
            <begin position="345"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="539"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000973800.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="80758" checksum="4A121A09091FB750" modified="2015-12-09" version="1">MNFIKCLIFYTFFIVFETNADEVVFEVGRRSLRERNFLYFDNQSHADQHELLVHISKAHPELVDKEITIVIVGYYNNEKRFIRYSLPETFKACVPEPNKRKLSIPTRKTKNSVKGILVQYSIDGQPLYKCNGRTVPSLKQLAECALKQRRLQFGRTCSKGFYKDEPSVCVGQIRPKEKSLEELFCEKPSTTYMFNFQKSLHDESFSNRVWFHIWKNRFNYECYSRDNFYLLKIRFLLEINTYRVSHKSSLLFENAKMTEKAQRRAEEIAQIGKLISDPNKEYEEIIDCAEVLMVPFMVKKWYDEINKYKYRFPLSKGRNKNFVKLLWKVTRYVGIGVAKRFCHSHADQFELLQHISKAYPELVHKEVNILIVGCYYSKEKRYLRYNTPETYKACVPSLNQRRPSISRIKKTNTSKGILLRYSINGQPSYSCNGKRVPSLKHLAKCALKQRQLQFGPTCSRVFYEDEPPACTRQKRPKEKSLEELFCEKPNTVYIAEFKKCLYDGSFSSKVWFNIWKDRYSYECYSMSNFYLLRKRYLLEINTYRVSHRSSLLVENAKMTEKAQRRAEKIAIHGKPVPDPIKEYEEIIDCVEVFMVPFMIKRWYDEINKYNYRFPLSKGRNKNFVKLLWMKTRDVGIGIAKHSCDVCVVLKFTRRKNKFKGYRNNIKRRNLNQLSLFKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVW1</accession>
    <name>A0A0N5BVW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVW1"/>
    <dbReference type="STRING" id="174720.A0A0N5BVW1"/>
    <dbReference type="WBParaSite" id="SPAL_0000996700.1">
        <property type="protein sequence ID" value="SPAL_0000996700.1"/>
        <property type="gene ID" value="SPAL_0000996700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000996700.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55229" checksum="709C6969EEE0C84E" modified="2015-12-09" version="1">MKVFSLSYLLFVYHFLILLCGIFVNLNGTLAEKKHEKFSIKIRRGQFIFDETDGQILPNDYEFLLSPDAEDDIPDRIYEDVFPDLPPHDYVLRGKYMGLVETKFTTPKPITTKFPHTKPPIEIPKNFKGQKDRFIWLNSLHDTLFPDDTQTNNNNKNSKKIEHNVPVKIKSGGQERDESKLHIQQVTTDLDIKKRVEEKNNISVSLKSKNLTGAVNELIKNNKKNGIDTLTNDYNDNISFNDALKLAEIEAKRVLEEYKRREEEEKVRKQEDKKVNENIKKLIQSSTSSNLISNKEYSTVNKLYNDSETSISTTSNPNSVANGNNINDILLAKLSDLTITTTMKPLTTKSIITTKISRNDNLSENTINVPVKSGKTSNNDITLSASFTVQSGKIEATTPLTLEKIKSTIRSQDFVVTSTKKPLSNISHCPTLNAYRDGKPHPKTSRFCQTIIPGIPNNNTCKCRYLVGSRDSNNCPSSFLYLCKPSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWG6</accession>
    <name>A0A0N5BWG6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proton-coupled zinc antiporter SLC30A5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 30 member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc transporter 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWG6"/>
    <dbReference type="WBParaSite" id="SPAL_0001016100.2">
        <property type="protein sequence ID" value="SPAL_0001016100.2"/>
        <property type="gene ID" value="SPAL_0001016100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000035">
        <property type="entry name" value="Zinc transporter 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="23">
        <location>
            <begin position="403"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="715"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001016100.2"/>
        </source>
    </evidence>
    <sequence length="789" mass="87522" checksum="AB1701CFE671D32C" modified="2015-12-09" version="1">MLAHDIFKKDRDRKLTNSKSSSYFGLLILAKILKCIGIFFIDILERSIHCITLLWLVKILASVILIPIQKPLSSGKSLSRLRGSIHARIGQLSLLNALVEVFWFYGITFCGPLRSILVFEHSSTVILVALTSFIKGTETTSKTRGVFCLIIGFIALFFMDPDTTIESNHPESHGHHSGLNYFFYKFLSMFGFADHKGGIFLLMIASLVKIYHDSSFRLLAVEIGGPKRLYAINTLMTGIFLSPLAILAYLSSSNIVDGYFSFFTLLIMATLFTFILDFYIESLCFQHVADPVNASARWSPITMFICSLILAYVWYQPFEDLGGTHMISGGVVITVFLFCCSSYLLTNQHTQKSHGGYFIGLSPSGMPLFTTGEAFLQKTSRSVWLFLQDTLKDILSNADSRRIFYFLCANLAFCGIEFTYGYLTNSLGLISDAFHMLFDCSALIMGLVASVLSRWPASKGYPYGYGRIEILSGFINAMFLVVIAISIFFEAIGRIMDPPEIKTDKLLFVAVAGLCVNLFGMYAFHGDHGHSHGGGSHGHSHSGNANMKGVFLHVLADTLGSVFVIISTILIQMFGWTFVDPLCSLVLSMLILGSVYPLLKDATVTLMQGVSDEEVSEYEVCLEKILSIEGVLSFSRVNFWQLKGGNNVISIHVQVKDEVNEQTVRCMIEKILNDEGIKECSIQIEKNSFTKRIQTTCPNYEFIPPTKKGQFLRTVEPTEDHCHSHSSNHGHSHGSENVHSRKGEHGRSHGNGHGHSHDGGHGHSHDGGHGHSHDSGHGHSHDSKHGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWS8</accession>
    <name>A0A0N5BWS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWS8"/>
    <dbReference type="WBParaSite" id="SPAL_0001026800.1">
        <property type="protein sequence ID" value="SPAL_0001026800.1"/>
        <property type="gene ID" value="SPAL_0001026800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001026800.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44992" checksum="28C8163BD1F98812" modified="2015-12-09" version="1">MSSTSKPIEKSDSKKNKTTGFFANENDLITQQNSKQIDKHQNMGYSKNMETGNEKCRKEQSKVAKELKKGKIKELKREEKKYKQKTYEISNDLITQLKKRMEMKKVSKVGAKEHGNIFQTNFPGNEYDCKSESMSRELISHDKNKLNNKNIERRKSVNVETCIEIDFLAIPSLQKNRTFSNQTFNEKKTLSKSGNEKFHRYALYDCKEEYEKHKKPYMSPNNKNNNWQIYDDYGNPWWAKFKVGPVSKLLVPQKNDEDITDDKLVINTQAILQVKEKRLIYSEPQEEDGFNDVYGPIRDLALFNDTQYGKTKIWWISLRNVIHMNLLVSKRKKLLTKESFSKVKKMESFNEKDPITIVRYIKGLPKKQQITQQIYQQVPVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWZ1</accession>
    <name>A0A0N5BWZ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWZ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BWZ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001032900.1">
        <property type="protein sequence ID" value="SPAL_0001032900.1"/>
        <property type="gene ID" value="SPAL_0001032900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="15">
        <location>
            <begin position="217"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="16">
        <location>
            <begin position="524"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="17">
        <location>
            <begin position="626"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001032900.1"/>
        </source>
    </evidence>
    <sequence length="725" mass="82788" checksum="A24AA077A01AACA5" modified="2015-12-09" version="1">MVSCEQQKKVDSPATTNSKSTHTETLPIVVRKSSLPYTSLLVLAFSGYDFEKSLLVLDEGDKNQTGIFVGGQWYTEDIDVAKFIARSSNKRALLLGNNFSDSQLIENVLSACSLNTPIPDSVCQSLANSTTSTVIPKKTTLADLALFVRLVNDKKLMEFVYFKNLYNKVLGDKVFESVHKFVGKVDPSKVEKIETKPKEKTKDKGKFVELPGAEKGKVVVRFPPEASGYLHIGHAKAALLNQYYQQEFEGQLIMRFDDTNPAKENAHFEDVIKGDLEILKIKPDRWTHSSDHFDMLLELCEKCIKEGKAFVDDTDADTMKVEREARQESKNRNNSVEKNIEMWEEMKKGSEKGIKCCVRMKIDMNSNNGTLRDPTIYRCKPEAHIRTGNKYKVYPTYDFACPVVDSVEGVTHALRTTEYHDRDEQYYYICDALGIRKPFIWDYARLNMTHTMMSKRKLTWMVDEGIAEGWDDPRLPTVRGIMRRGLTVEGLKNFIVAQGGSRSVVTMEWDKIWAFNKKVIDPIAPRYTGLLKQDLVAINVLNQKEEINKEIDLHPKNPSVGKKFVTYCPKLYLEQEDAKSLKVGDVVTFVNWGNMNVKNIVKDGDIIKEISIEYDANNTDFKKTLKVTWLSNSEKSKLVNLICNEYDYLISKPIIGKDEDWKDFINRDSHKILEMLGEESLKNLKKGDIIQIQRKSFYICDEDYNEKSNTLKLIAIPDGSSTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX55</accession>
    <name>A0A0N5BX55_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmodium variant antigen protein Cir/Yir/Bir</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX55"/>
    <dbReference type="WBParaSite" id="SPAL_0001039050.1">
        <property type="protein sequence ID" value="SPAL_0001039050.1"/>
        <property type="gene ID" value="SPAL_0001039050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894972" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001039050.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16821" checksum="0AD2801A06CAF46A" modified="2015-12-09" version="1">MKLITKFIYLFNSLILCSCGSEEEYRDFLMNKSNFFHNLIFDIGYGVRKCIENQNFYPYEKIFIDRSDKNYTNDMVTGFFVLFSFFLLCFFVLSVIYDIITSPIYITLALRRWYKTIVEEERRKKRMKSYQNRDELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXT7</accession>
    <name>A0A0N5BXT7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXT7"/>
    <dbReference type="WBParaSite" id="SPAL_0001060500.1">
        <property type="protein sequence ID" value="SPAL_0001060500.1"/>
        <property type="gene ID" value="SPAL_0001060500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001060500.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24099" checksum="1DF91FA7EBC864A8" modified="2015-12-09" version="1">MCDDGHGHGNCCHYEIGDKETFEEGMRYDLNQCIDFNKTITLNESIDGSGKLIFKDFENRHDKVRFVESDCDEELLFNITFSGHVKVSGMTLIGNLDESHPSQMKIFKDKENMTFDDVSIKSDFECSLKQDNLAIVDYALPATKFSNCKTISIYFPSNFGGETTILYYIGLRGSFVHETREKIVIATYEARAQLEDHKAELPETNLSRNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXV9</accession>
    <name>A0A0N5BXV9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXV9"/>
    <dbReference type="WBParaSite" id="SPAL_0001062250.1">
        <property type="protein sequence ID" value="SPAL_0001062250.1"/>
        <property type="gene ID" value="SPAL_0001062250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001062250.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19493" checksum="2F5386D2EC815301" modified="2015-12-09" version="1">MKYYIFIVVTVALRCYCRYYYTHDNMHNPFHEPLTDEQWQRIYEIENDNTITRTQIIQNVFDYLKRQVENLTVNAQKQIESNLTAAAFEELVIFNNAFSASPLMNMHVPSGFFTVFRKDVNGTQKYLDYNYAILKKSSKDLSIHLDQVEADILNKTYKSHNFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXX9</accession>
    <name>A0A0N5BXX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXX9"/>
    <dbReference type="WBParaSite" id="SPAL_0001064200.1">
        <property type="protein sequence ID" value="SPAL_0001064200.1"/>
        <property type="gene ID" value="SPAL_0001064200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001064200.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11266" checksum="E47347464A9AF6EF" modified="2015-12-09" version="1">MNTNIIQDTLNDSKNLLMPVIATLLSCTKPMICSNYDKSQDASVELLGVIKNLYWEEILKTCGMPVNSYTEEDELKRIKSAQKARNLLVDIAMNVTGAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYT6</accession>
    <name>A0A0N5BYT6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BYT6"/>
    <dbReference type="WBParaSite" id="SPAL_0001093400.1">
        <property type="protein sequence ID" value="SPAL_0001093400.1"/>
        <property type="gene ID" value="SPAL_0001093400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF375">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895332" description="guanylate cyclase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="549"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001093400.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="85217" checksum="B5CF2171A8D8959B" modified="2015-12-09" version="1">MFFNFLFLFFCISYFNCQNNVTSQSTTMNKLNVGMFFPRNSSTQIYWQGYQNSAGAVLEAFRDAKKNYSILNNVTIEYYWVYNECVVSSTAGYFFEMITSENYSIDVMIGPPCTDTAPITGSIAAYYNFPVFLYGLGSVFNSFNDTTLYPTVTTVMSTYNYGARGLAEMIIKYKWTDISLLYMQSEKYLYMCEKFGTEFDNLISKTYDNANIVYKRAISNFTSSNLDFIADLVNRVSRIVVICLEEQDKLRSLMLAFFDNGMNSNEYVYINADVDMDYYVNHENMLLLKDYSNPPDGRDNDSYSMYKYMLHFQYSIQGGMSSKYNDLRILMPQLMGEAPFNCTTECGIYNVSSVYAPYLYDATYVYYACLAKAMADNKDNVPFKELARNGSLITQYSVGTYQGITGEFSIDSLFIRSATVTLGTYMNDGANVSNWVEAFVNNKNYSLKYLYTDPKTTIWESRGGEQPLNEPKCGYTNTNCPYDFIKKNPILFGLIILVCVIILIIVILLCLYFYIQKKREEEKQNDLWKINYNLLIKYEDHEKSMSMIQSKKSLVSAGQSSAKLLSKHNLEGRHRLFVYMNEYVMARIHDYQYILTRKDMAHLRSMRMMDHDNVNKLVGFSLNGPTLMSIWKYCNRGSLAEILTNESININIDGFFVYSLIKDTVEGLNFIHRSSIEVHGNMSSRNCLINERWQVKLSDYGIPFLRTFEEQKPEHLLWTAPEILRCDISHPNKESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYU8</accession>
    <name>A0A0N5BYU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase_H2C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYU8"/>
    <dbReference type="WBParaSite" id="SPAL_0001094600.1">
        <property type="protein sequence ID" value="SPAL_0001094600.1"/>
        <property type="gene ID" value="SPAL_0001094600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001094600.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="16034" checksum="7A7B4D32E89495A9" modified="2015-12-09" version="1">MFNTGGFYDKLEEQKLIKYVHEYLDHASFKRMKHFLELRGQEKIINNLAGKIRRFLQSCLLCKKSNSNTKRTGLEFTHVNLEYPKGRLCALCRSINNKLEYRWDGPYIVDEVSDDYVRVKEERGVWNRTHVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ05</accession>
    <name>A0A0N5BZ05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">REJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001100100.1">
        <property type="protein sequence ID" value="SPAL_0001100100.1"/>
        <property type="gene ID" value="SPAL_0001100100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001100100.1"/>
        </source>
    </evidence>
    <sequence length="55" mass="5795" checksum="954A08D1C35FE105" modified="2015-12-09" version="1">XDVEPFAWNNIISSISSVSSSVMWSHLSGITSFNSSTSVTSLSVITIPSTSFTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZS1</accession>
    <name>A0A0N5BZS1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZS1"/>
    <dbReference type="WBParaSite" id="SPAL_0001126100.1">
        <property type="protein sequence ID" value="SPAL_0001126100.1"/>
        <property type="gene ID" value="SPAL_0001126100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001126100.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9465" checksum="A34AE5F8B836781A" modified="2015-12-09" version="1">MFNFDFKFLSPYSYMLRPIENAFSKVKSCVRSRLRNNENGVLSDIIMSETNNITSTDCNGYFRYIYNKYYKLWCGTSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0V6</accession>
    <name>A0A0N5C0V6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0V6"/>
    <dbReference type="WBParaSite" id="SPAL_0001163500.1">
        <property type="protein sequence ID" value="SPAL_0001163500.1"/>
        <property type="gene ID" value="SPAL_0001163500"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001356600.1">
        <property type="protein sequence ID" value="SPAL_0001356600.1"/>
        <property type="gene ID" value="SPAL_0001356600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001163500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001356600.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10154" checksum="22AB2A923720D777" modified="2015-12-09" version="1">MIVVSGNMSFCKVPPGIEDPTDLCSQCVSVGGTTDNKKKEIFLFVMGLLAPIIRQIGEHFPDTGISEFLRSAAVASTAPTDTTTTMGDDKEIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C187</accession>
    <name>A0A0N5C187_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UAE_UbL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C187"/>
    <dbReference type="STRING" id="174720.A0A0N5C187"/>
    <dbReference type="WBParaSite" id="SPAL_0001176500.1">
        <property type="protein sequence ID" value="SPAL_0001176500.1"/>
        <property type="gene ID" value="SPAL_0001176500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001176500.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13353" checksum="4CD813EBDA1A2453" modified="2015-12-09" version="1">MTVNGLKNEVLIKDMSLTSPSACCNKTGKIIICDEDSIPEEIMRKTLADIGVTSGSFLDIDDFFQQFNLVLCLHHSDELGELEFEDISSSYGEDHMVSSGKRGAADTIDEVAHDAKRLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C240</accession>
    <name>A0A0N5C240_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C240"/>
    <dbReference type="WBParaSite" id="SPAL_0001205300.1">
        <property type="protein sequence ID" value="SPAL_0001205300.1"/>
        <property type="gene ID" value="SPAL_0001205300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895217" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001205300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16499" checksum="F3463E5D09232DA7" modified="2015-12-09" version="1">MNFNFYILIVISFIFNIYYASAIKCQTLHDTSKHLNDRIKFEYRTVECSGLCYRKDDANFNKTLGCTTDPVNGIENMHNATIPRCFIEYKGNYVLCLCNWDNCNIMKLEFLQDEIIKHNNSSDKLKISLTILITIIMTLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2I8</accession>
    <name>A0A0N5C2I8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2I8"/>
    <dbReference type="WBParaSite" id="SPAL_0001219600.1">
        <property type="protein sequence ID" value="SPAL_0001219600.1"/>
        <property type="gene ID" value="SPAL_0001219600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001219600.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9167" checksum="7EB8B28718F5AE6A" modified="2015-12-09" version="1">MPLISTLYINVYYYLKFQRNVSSLFAEIVLMLIEKGYAIFCPITLVFFIETYRTYFKNLLCIKNKISVKHSSSKAIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2J5</accession>
    <name>A0A0N5C2J5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2J5"/>
    <dbReference type="WBParaSite" id="SPAL_0000615800.1">
        <property type="protein sequence ID" value="SPAL_0000615800.1"/>
        <property type="gene ID" value="SPAL_0000615800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001220300.1">
        <property type="protein sequence ID" value="SPAL_0001220300.1"/>
        <property type="gene ID" value="SPAL_0001220300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009790771" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000615800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001220300.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18634" checksum="E0A674DF6DCC5E99" modified="2015-12-09" version="1">MKFLISFLCLLTFINVSYSLGGSKRSADAEPQWNGEIFWKNLAKNLELTIPDNVPQWNGEIFWKQLMKKLGKNVEANKPQWNGDIFWLNLLEKSQKGHPPVEPQWNGDIFWLRALDDVEKVYPDAEPQWNGDIFWKKALTKILEKISKIPKEYVADTKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Z4</accession>
    <name>A0A0N5C2Z4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HIG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Z4"/>
    <dbReference type="STRING" id="174720.A0A0N5C2Z4"/>
    <dbReference type="WBParaSite" id="SPAL_0001235000.1">
        <property type="protein sequence ID" value="SPAL_0001235000.1"/>
        <property type="gene ID" value="SPAL_0001235000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF17">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001235000.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14822" checksum="35077E559F182648" modified="2015-12-09" version="1">MFKSYFKNVFCRVAECSTTHHDGEGNHGEKHHGFVKTPGVPAMPLDIGYKSGKDTQGSRGYVASDGILSNPLVPIGMGLTCLALLGMFKNSMAGNKMGTQKFMRYRIYAQFGTVLAMVAGLVYAGSTFSDKKKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C357</accession>
    <name>A0A0N5C357_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agglutinin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C357"/>
    <dbReference type="WBParaSite" id="SPAL_0001241200.1">
        <property type="protein sequence ID" value="SPAL_0001241200.1"/>
        <property type="gene ID" value="SPAL_0001241200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001241200.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16010" checksum="C289933F9E3032FF" modified="2015-12-09" version="1">MDQQQKEVCIDFYTDDNNTSTAIELNSQYSMSTFGQEFHPYSRTDYYHASASHRIKELYNIALAKSDNTPNNINFCKIVKSEDQTQVTVAITEFSRAYFVKKSNGDWIFLERSNDGKHNTMYIMDREKNGNSVKVMCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4D4</accession>
    <name>A0A0N5C4D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4D4"/>
    <dbReference type="STRING" id="174720.A0A0N5C4D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001281500.1">
        <property type="protein sequence ID" value="SPAL_0001281500.1"/>
        <property type="gene ID" value="SPAL_0001281500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895545" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001281500.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12222" checksum="425466856F4502CA" modified="2015-12-09" version="1">MQSYIVLTILLTVFAAIFIANAQQYDESSIGFSPEKRAMRNALVRFGRAGMRNALVRFGKRSMDNEMQEFALKRNAAPQPFVRFGRSSNLPIEGYYVPYNSLYGNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4F3</accession>
    <name>A0A0N5C4F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein Skeletor</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4F3"/>
    <dbReference type="WBParaSite" id="SPAL_0001283400.1">
        <property type="protein sequence ID" value="SPAL_0001283400.1"/>
        <property type="gene ID" value="SPAL_0001283400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895335" evidence="2">
        <location>
            <begin position="21"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="3">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="3">
        <location>
            <begin position="161"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001283400.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="60484" checksum="63265818DEF6982B" modified="2015-12-09" version="1">MAKQLYSLFCSLIFLGLTFSSHIDNNYVTNTYDSQYGVYIGDFSNLLGANISGKVYVVNETALQVLNFTLNDNISDLYFWLDKTDHPTKDGVKVPTFEYGISELGKYNLEDNDRVVLNLPKRFKVVNFKSLSLYALNTDTNYGSVLIPDNLSPPKPQFLGQEFKGSRYSLSSGPILITDRKTIKIFGFTFDADKAPDGYFFAGKGTNVASNSGAKIPIKGRDTRENINPMNERYRGGQDIVLELPDDYDIFSIDWLSVYIFRFSVDLAHVPITNISQKVPPYVPAQKTYGENIDGEPWRVTSLLGTQSRTNFTFQLGPSGGMKGYANMMHSRPPKNVWYVNGYLCEIYLKRGETYNFIVEGGNEVKSQEYNNALYISEDKYGGYERLSNNEKQDSVIIAGGEKMAGRRCEWIQDNENDSPNNYDSFASYKKTLKLSCNTKDKPVSFSYTPTAETPSILYFNSYNNYNMGSKIHIVDELPTDIEDIHEEPYHHDAWLEQQSVRKSPRKTNSTPVNSFTHIIYIVVGVIVYQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4I8</accession>
    <name>A0A0N5C4I8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRR containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001287000.1">
        <property type="protein sequence ID" value="SPAL_0001287000.1"/>
        <property type="gene ID" value="SPAL_0001287000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001287000.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8947" checksum="947AA063621CF533" modified="2015-12-09" version="1">XDISIVIDLDYEEEISRLSVLKQFILISNNRVNVSKTCFRKLIYPKRQLEMLAESDPSFDLSNRPVVVSQVTKNYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C643</accession>
    <name>A0A0N5C643_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C643"/>
    <dbReference type="STRING" id="174720.A0A0N5C643"/>
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        <property type="gene ID" value="SPAL_0001341800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="6">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="5">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="7">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
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        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
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        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001341800.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="66290" checksum="FE997691E360FAF2" modified="2015-12-09" version="1">MYQKGYGTMQKSRRLQNNGSKILKDEENQTLFRLCGPNAISLAAGVCQLLRSSPKPNSVWEVVSPGVIVFCKDYERRLYCLRLYCLAREELIWEQIMYVNFMPEYLWNKKNMLVFEGEKCMFCLNFTSDAEAGIFYDHFQRRLMKEKENAAKATKSQDIKLQSTNQGSVISHSTGISAMGAVPFYSPTQKTSTLFGNGKDEKKGKKKEKGRKICKEDISFPSNFQRIAHIGFDQHSGFQHTVSDSSAIDDSVKDVIKAAGFNPDNMNHDEIKFAKEFVSNYDPFDPNKYRSSSNDPFNAWGDVPSINRYSTSQTNYHESSYNPPVTHKKNMAPVPAYNVKSNTPNYYNSNQYPHNIQTSQPVQGKYYNDFNNSTQRTTPAPPPPIRKDINNFQNEISGKATNNDMMPIRTAPTAPKRPTNMPPPPPVKSNRPPPPPPVLQSLNPISTKQSPAPTIPSSGGSCAPPPPPLPPPGLLKNPTSPQKPQPPTNNGRGDLLAEIQNGKTLRKVEQNSSEGGKTNNTRDDLLAQIQRGTNLRHVESSDNEVQNRKSSTNIYQAEGIAGALARALEERRKNMVASDSEDSVSDNDEWDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7E1</accession>
    <name>A0A0N5C7E1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7E1"/>
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        <property type="gene ID" value="SPAL_0001385500"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="286"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
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            <begin position="192"/>
            <end position="206"/>
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            <end position="230"/>
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            <end position="245"/>
        </location>
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            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000046392"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001385500.1"/>
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    </evidence>
    <sequence length="303" mass="29379" checksum="32B8FB0F0E45CCDE" modified="2015-12-09" version="1">MDLEGRIKAYRFVAYSAVVFSIVAVLSVCVTLPMVYNYVHHVKRSMHTEVQHCKESAKDIWSEVNTLKRIPIINGNRTARQAGYDAGVSGGSASAGGSCDACCLPGAAGPAGAPGKPGKPGKPGAPGLPGNPGKPPVQPCEPVTPPPCKPCPQGPAGPPGPQGPAGDAGADGQPGAPGQDGAPGQPGPKGPAGPNGNPGAPGPDGQKGADAVSEPVLPGEPGPAGEPGPQGPAGAPGQPGAAGAPGQPGPKGPAGPNGQPGNDGQPGAPGAAGEPGQPGEKGICPKYCAIDGGVFFEDGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7J4</accession>
    <name>A0A0N5C7J4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7J4"/>
    <dbReference type="WBParaSite" id="SPAL_0001390700.1">
        <property type="protein sequence ID" value="SPAL_0001390700.1"/>
        <property type="gene ID" value="SPAL_0001390700"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001390700.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57117" checksum="B690BC0687A0D45F" modified="2015-12-09" version="1">DDINTRTHLRGIQKLQRINGMTQEIYAKQDEKILNKNSYVDEDQSTQPLYNENQYPRKMPLISDEPVFSSDDRSQVIKVKHRKSSSPPSNYQPEAFFEPSKEDIIKRPVSEDTIDKIDEMMDKVKSRFFVTQNNNNNNNNNNVLENEKTLSNEQKTITTDDESVKKERLERIRARWAKLGPIIKSRVNRLFSKARLSQNYSIGKEIRRFSTTTPKTFELDKKQYIESNFDTFTEVNHNDRPVLHSVKTMTDDKFLGQNEIKNLGTYNHIIKRPPIAKPTFGNELVNLGNLDNEGDLHNRLSNNFGEQRRTHYKFVNKVSSRPRLRIRRPGNPPTAQAMENEVVRAAGISSLNRGPLSLPELSPITNEESNENQKIKPIPLPSIEKSDETSRSFKSDESSESLIDSSEITFGNPPPKSDEKIKPNKSDEFDSNSKSKEHINVEIEPPLEPTDEEISSLSRNHNKKKVKVEEVDSGDSGILPQNSGLRPVAPPSEFGSTGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7P0</accession>
    <name>A0A0N5C7P0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7P0"/>
    <dbReference type="WBParaSite" id="SPAL_0001395100.1">
        <property type="protein sequence ID" value="SPAL_0001395100.1"/>
        <property type="gene ID" value="SPAL_0001395100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895540" evidence="4">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001395100.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10480" checksum="87402322C894558D" modified="2015-12-09" version="1">MIVVLLHIILILIQLCESESIIKTQHGDIQGIEKTFPEGVVTEYLGVPFARINSKRKRFMPSSELRKPEWKGVFHAKTKAVSCYQHLIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8E9</accession>
    <name>A0A0N5C8E9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8E9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8E9"/>
    <dbReference type="WBParaSite" id="SPAL_0001419800.1">
        <property type="protein sequence ID" value="SPAL_0001419800.1"/>
        <property type="gene ID" value="SPAL_0001419800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF118">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="468"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001419800.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="72574" checksum="4436775C17872173" modified="2015-12-09" version="1">MKKHVVLRNKLMIWFIIIMVFVFLWITVTLLFFIINDNFKVIKEYKEIKENVDTFNGHKIQVVVGHYISSPTKKAKINYTYEELNANSYNPQKGYGSDGLSVHLNKQQQSLGKHLFEINQFNLVASDLIFANRSLPDQRRKKCRNIKYDNNLPDTSIIIVFHNEAYSTLIRTITSVINRSPLKLLKEIILVDDFSSRTFLKKELENFVIKQPIKIKIIRSKVRVGLIKARLMGANEAIGKVLTFLDSHCECTIGWLEPLLQRIKDNRNNVPCPVIDVINDETFSYQKGIDIFRGGFNWNLQFRWYSMSSKVFKERTDSTAPIPTPTMAGGLFSIDRDYFYEIGSYDNNLDIWGGENIEMSFRIWQCSGRIEIIVCSRVGHIFRKSSPHDFPKGKSSNAVIFENLARVAEVWMDDWKYLFYQTSNLAKNISKRIDVSDRIELRKKLKCKNFEWYLKNIWTDHFLPMPNDRFGRIIHGESLENNKESCLHWYTISKGNKRPKMHNCSMVHFDSTEIWLINEKGQIRSDENVCLSASPNGGSGTDYQLQAKECMDYDIEYWKFDTTYNNFVHLNSGLCLGKPSKNQFNESGNIIANADEYIPKIDKCNYQKNQEWSIIDFKWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C917</accession>
    <name>A0A0N5C917_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C917"/>
    <dbReference type="STRING" id="174720.A0A0N5C917"/>
    <dbReference type="WBParaSite" id="SPAL_0001440000.1">
        <property type="protein sequence ID" value="SPAL_0001440000.1"/>
        <property type="gene ID" value="SPAL_0001440000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001440000.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="35258" checksum="7114F17D15001C83" modified="2015-12-09" version="1">MKSTYELNEYDRDPEFNHCYEKNGFAVIQNFATDKECDELREEMRRIVNDMKIDEHPKSIFTTTDNEKHLSDKYFIDSVDKISFFFEEGAFNEKGEMVVDKFTSLNKVGHALHEKNEKFKKFTFSEKIKKICKVMKMVNPRIIQSMYIFKNPKVGGVVTEHIDRSYLHTNDGEQLLGFWIALEDVTFENGCLDFYPSSNNEVKVTYRFSRDLSDPEQKLIHVGKKPEFDKECFTYAPVKKGSLILIHGDVVHKSKPNKSEISRNVYAFHVVDRNRDLEWPKTNWIQETDDYKFSSIYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9E8</accession>
    <name>A0A0N5C9E8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9E8"/>
    <dbReference type="STRING" id="174720.A0A0N5C9E8"/>
    <dbReference type="WBParaSite" id="SPAL_0001453100.1">
        <property type="protein sequence ID" value="SPAL_0001453100.1"/>
        <property type="gene ID" value="SPAL_0001453100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001453100.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="17039" checksum="3F5295AB2C693F9F" modified="2015-12-09" version="1">MSKNLYDILGCHQSNSTEQIMQEYRKLAKKFHPDKCSSDEAEHFKNIQYAKDILTDVRKKEHYDLYLKLGNFMPLKDWMDNLEHFQQSLHWRTPKPQQSLAMKEDKGEIERGNEVSNLLTMSSGSSWRRHNNETINAFRNYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9P2</accession>
    <name>A0A0N5C9P2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid-sensing ion channel 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9P2"/>
    <dbReference type="STRING" id="174720.A0A0N5C9P2"/>
    <dbReference type="WBParaSite" id="SPAL_0001462100.1">
        <property type="protein sequence ID" value="SPAL_0001462100.1"/>
        <property type="gene ID" value="SPAL_0001462100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF244">
        <property type="entry name" value="DEGENERIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001462100.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="55170" checksum="A308E0429C84F921" modified="2015-12-09" version="1">MSLKEIIKDFSNWSGVNVVTQAYYSRNKKILFLWILFMISMLTLTILLIMQKIFVKKIETKVLTTRRVNEDFFPKISVCFNIHNKYDEDSIFDSDPEFKNEFYGKKFSTEMKTNSFHDPEMYINNLQRNFRISYKKSLTGQDDLTKISVIECTYLGQNCNKFMTIINYDEHGIGRCFLFENKKQKFGAFSRVGKEFGLSVLLKNEISDIKNHFRKAYGYPPYLSIQYQILNPKDKENHLLTTFHTDVLPLGYEVNIPITITKEIKNKATTNCLDYNTEDPDSLHESGAYTYESCYTNCLKKNQLAQCPSVTPFEPNFMMCGKVKPCTCNDLNCFNCLSDSLFPNNLNNGNLHPEFKDKCSCPPPCESYTYKTNPNYSKLHAKNMAAMLGITGSEEDLEDDISANYVILNFFIKEHTVLTKKEEIVYRSANLFADIGNSLSLLLGLGMINIIEIFFCLFLIIIDRIRYFIKFRHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA59</accession>
    <name>A0A0N5CA59_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA59"/>
    <dbReference type="WBParaSite" id="SPAL_0001478400.1">
        <property type="protein sequence ID" value="SPAL_0001478400.1"/>
        <property type="gene ID" value="SPAL_0001478400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895604" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001478400.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10121" checksum="8A7C17273B9B8973" modified="2015-12-09" version="1">MNFKLYLPIIAFVLVAFSLNCYAELEDSGSDVFYSAEEGLLPETKNTNTQTILDPVSGEDDEFFDAQEVVKRSPEAPTIVRGGHDYDLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAN5</accession>
    <name>A0A0N5CAN5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal_L16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAN5"/>
    <dbReference type="STRING" id="174720.A0A0N5CAN5"/>
    <dbReference type="WBParaSite" id="SPAL_0001495500.1">
        <property type="protein sequence ID" value="SPAL_0001495500.1"/>
        <property type="gene ID" value="SPAL_0001495500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001495500.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10770" checksum="7447B1952914D456" modified="2015-12-09" version="1">KKQAFYDEFPHCVHLISNEREHLSSEALEAARICANKYMVKNCGKDGFHMRVRKHPYHVVRINKMLSCAGADRLQTGMRGAYGKPQGLVARVGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAQ0</accession>
    <name>A0A0N5CAQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5CAQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001497000.1">
        <property type="protein sequence ID" value="SPAL_0001497000.1"/>
        <property type="gene ID" value="SPAL_0001497000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="291"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497000.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="80833" checksum="B4D8D896CFAE09CA" modified="2015-12-09" version="1">MEEVQYPNNWQYRRSVKRIYWNSGMASTGPEAKNQKVIERERKKRQRRWTKIEAKLYATISHYRANNVELYVKEFQDIVNKIIDEKKHENVCGIIKLMEQKFGPMPKTKSLKEEVIDTTIVETRKVNSKISLPPFCISNYNLAQIFLSRCIVDYLKPRWLRTSSRKMNSQHLIMKIKLSEDQYERTPSIFPTIHSFFQSSMYKIRQDPIDEVDFWRPFYKVNKFNINDTHSDFPKYSDEILSLTGNELKPYLLLNDTQMSQLTYPLPYHINNRNQFIQTREFYDKVTSESPFFTIDCEMVNTNEGLGKLARFSLLDQYGSILMDTLVKPKGVVTDYLTKHSGIYPGMLDNIDVTIEDVQEYLCKVLPPDAILVGHTLNCDLNALGVCHPYISDISALYNYGRRIVNRISLKNLVGSYLNVSCQDGGVHCSVEDSIVTMNLYKQKLKYGLGYGNYHYGTKEQTVNFKKRNEDSESSSDSSIDIPVKREKVDNEDTGDGVGSDEDNEGKEEGFVPVKKESTCNRCKRVITVPCLIPGCPCFENAQSNCIKCFNETHEAPKNKDTTPIEWKKPINGDDVTEASDSVNLTEYLDGKGNIKHGHHVLFAGRGFSQWVEKTKHIDVMERDNYKDETAFLTDIGSTVWQYSSLAVSLNLENEKETPDSINAAIKSIINGLSINALFVCVLETPSRKCLYLKSKIRKNFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAQ1</accession>
    <name>A0A0N5CAQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAQ1"/>
    <dbReference type="STRING" id="174720.A0A0N5CAQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001497100.1">
        <property type="protein sequence ID" value="SPAL_0001497100.1"/>
        <property type="gene ID" value="SPAL_0001497100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="253"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497100.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="67889" checksum="96DC033BB587B2E9" modified="2015-12-09" version="1">MVVPQEKNKFNNIGSIHGDGYSALPKSGSFGHCKSLPHVKETFPLEPRKTVELTEKEKNFVRSLSCSMGGNDRQGAGLPGQLKFRPVIGDGGNHPHCHDFPASPVSHFHQPHHHPSPALHPSAALPGNICMGMPADFVQSFLQGPFAVSPLPPCYINNGCMGPFLPGYHLPAAYHHPGDGSFKYTNVLDSLLPHNPISSVMDMLTPPPEKTSFNESPSGGGPMYKVSKKSLSSSNGTNNNNSQNNGSGGPLNNNSKLLEEFRNGRAQNLDLLSIKDDIYAFATDQHGSRFIQQKFDAAPASTRDVVFESILPHTLNLMKDVFGNYIVQKFFESGDRNQRSQLLDMVRGHLVELSLNIYGCRVIQKAVENAEDCDVQMILSELRVGNKVIKCMVDQHGNHVIQKVFEHVKPDSLNFIIDIVKTCCDELPIVSLAKHNYGCRVLQKMLKHLLPHQKEFIVQQLQSHLDELLVHQYGNYVIQELFKSSSTVVKHYIVIFIKADLEKYSMDKFASNVIEKCLIDGDQEQVKTLVTKIFEVPFEDLLYRMIGDQFGNYVVQKMLDVCDVQNRKKLIAAIKPKQAFLKKLPFGKHILAKCSESQSSPQKDKEASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAQ6</accession>
    <name>A0A0N5CAQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cas1_AcylT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CAQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001497600.1">
        <property type="protein sequence ID" value="SPAL_0001497600.1"/>
        <property type="gene ID" value="SPAL_0001497600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter TMD0" evidence="3">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497600.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23073" checksum="A86F37F5EC08F595" modified="2016-05-11" version="2">XTKIVDFFSPNITLSQSLQTFASCYQNNLMVIIPALFLFIFFPILMFALHKSKNPKLEVCSPVGGRITIGIILITITAVQFFYNTYRKWYSSKNIPLSWIYSTGVRYISLCFALFLTLACRNRGIVTSGVLFNYWLLLLVCSIPEFIGKYNYYFDKSDIFKNLFNNKFEEFGSADDNLLQYSTIQNILFIIYFPLLIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAR1</accession>
    <name>A0A0N5CAR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001498000.1">
        <property type="protein sequence ID" value="SPAL_0001498000.1"/>
        <property type="gene ID" value="SPAL_0001498000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895625" evidence="1">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001498000.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="58422" checksum="3F78331A31E47157" modified="2015-12-09" version="1">MNVFILILYTYALFSVSHGGVIEWLQDTWGVLKKLNFEFWHKHPASRILYEYLDPDVDPCDNFYKFSCGNWIKTLEKTKGNSKSFHFDSRTRNFDKFTDEFYEGKYNNETRIFPTFLNLLEKCKELPEDEIYYCNLEIFNFGKYALSSVFLKKNKIKSEENGDYDTVENITMLIKHEFRSLIDEKKDDFDEETRNNFKYKLDKMEFVRNFDNFDLSNVTLMEGCYDNIGINYNDHIENIRKAIKRYIKMSDNDKDGLNSCMVKIFQPNEFITRYVYANAWYNFKGNFFTMNSDTLNEPSFSKDYPYSLNFGYFGNAIAHEILHAFDNENYNRTLEGDNKNYFNVSQKSIEKYREKSDCFANQYGMQKESTTNRSINGRFTLAENIADNGGLKIAHRAYIKYLQSNDGSSSKVHGFEQFTDEQLFFISVGKNFCEYTSKDNLEILMNTDDHSPPEIRTNVLLSNYKPFSDAFNCPVNSKMNPEHKCELWKYQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB42</accession>
    <name>A0A0N5CB42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bestrophin homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB42"/>
    <dbReference type="WBParaSite" id="SPAL_0001510600.1">
        <property type="protein sequence ID" value="SPAL_0001510600.1"/>
        <property type="gene ID" value="SPAL_0001510600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001510600.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15113" checksum="FA3587D62862E5EF" modified="2015-12-09" version="1">MSVKLITSLASNIFLFGFNGLFQLFSIVINFYLITLQRVLLSLLIIFGEIPVSRHEPMSERKGLFIYRIIRNYVNLIQYVRNWLGRWYNNDILKAAPIPILYEDDEIDESFFSSDKESVSSVFGDSECES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBJ8</accession>
    <name>A0A0N5CBJ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBJ8"/>
    <dbReference type="STRING" id="174720.A0A0N5CBJ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001526400.1">
        <property type="protein sequence ID" value="SPAL_0001526400.1"/>
        <property type="gene ID" value="SPAL_0001526400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001526400.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35836" checksum="080BBEA14464DC2A" modified="2015-12-09" version="1">MDRMVFGNLINNMTLYGTPGMPNDIGERLRFQQTVLQNLAFWQNYNHYTSAIMAAQNFLPPSPLSLLTTTTPPQILISSNSSSIHKNRVRSISGTPKDDLEETPRNKNYREMIKCNSCDKCFKTRKEHRQHIILHHERRFECERCTKTFLTQGLLDGHINKKHSPDDGKKIKNVNEKYCKQFQCKICDRSYETYYNYKEHLAKHDGKIFKCSVCNKLLSGQSALSRHTKIHSKPHECIICKDRFSSAYDLDCHFSYYHSSIKRFRCQFCNRALYNYSGKLRHERLCLGTNTNDKNIKEGEEKENND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCV2</accession>
    <name>A0A0N5CCV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CCV2"/>
    <dbReference type="WBParaSite" id="SPAL_0001570200.1">
        <property type="protein sequence ID" value="SPAL_0001570200.1"/>
        <property type="gene ID" value="SPAL_0001570200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF4">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895698" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="628"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="735"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001570200.1"/>
        </source>
    </evidence>
    <sequence length="1537" mass="169887" checksum="67AFE1CC4AFDEC9B" modified="2015-12-09" version="1">MGCISIILLLVVFFYQCDCYCEPGVRCDECELIENDDVCYVEDSKVPNFYCDVEGNSVKLSENSYFYCLNGRWFLKYCENGAVFDIKNSECYKELPLYKKKVKRSSGGARAGDICQFNTDCQSGMFCSSGTCTCLSDYVSISGYCWPKVNPGQSGCHEDKQCNVVWPNTKCSPGGVCECSEGYVPSRTRDGTVCITASVPPACPLPESLDDEPNPATILGNSKNHPLSPGNYMPVLCTSTSTEVHNSNGGDGSTWCIYPDGENDIYIADIYDCLETPQVNNELFREYAPSVNGICCPSRAFVCIQPMEQGNEPSVPRWYYNSISGACSQFMWDPNSGENVSPNNFKTQEHCETYCGSCKRGPTQYYTSKHTIFEDTPITNCMQSSTCSGDFKCTLLGSTQACCPSISNICSPLGGRPHFVKPLGMSDRGVLIHGSKTVTRYYYDPNLGKCVNFLYDGLGNFNNFITKFDCENYCSRLMCPFGNPLMVGEEWQKCESSTDCPSSHVCDTTHRVCCPTAQNICSQPKRPGECKNSVRKYWYNIEMRQCQIFEYSGCNGNDNNFDSLPLCQQTCRNIALEPKCPQGKAHRDVNGNFFTCSSKHSDQQCPPNYYCYFDGNSYGCCPTKSYTCSLNSDKGVQCGAGTSFKYYFNPNKNSCEAFQYLGCDGNSNNFQTLEACEEYCGIVCPHGGQPLRDVSTNQLITCSNSNKCIDTHECVTLNSNGNVVQRCCPSKSYICSMPPQQGTLCTKMPVTRYYFNIVTKECAKFSYNGCNGNLNNWPSIEQCRNFCHSSACTPGDIVYINPNTNLPYECNTALTNTCPTNFQCLFDQLTQSSVCCGASSMGVCPDGEKAFVNAADMSVRECLVNVEGSCPANYLCRFNPLKNRYYCCSSITGELCPSGKAVARDNSNKNPIRCHVNGGNNQCPNGYSCQTSVSGALQGYCCSSNYVCPNKGDFYIEENSQMPRSCTPGAFVGCPGGYSCQRTTPDSPTGYCCKGEIMGVSDGCPPNEYAYMKNYKVVECDPFNIQNSPCPKSYTCQWGKDKYQCCGKEPIFEGMEESSNHGCPNFQVAFIDKTTKSPQFCSSSIPNSCPLGYFCQFVNSNQYGSNKYICCGNKSGCPGDSVGYIDISGSPKECKMGFLNDCPEGFVCKSVGNKGKNICCTGTEDDFLNKNSALMNVAMNPVLLTTERTTISRSRNLKIQSRLLALANVTLPPLNIPPKRKIKKCDIKETIKNRKCAPRVIGDKCIKTIQCPETTECINKKCSCPSNKIERNGKCVDMLEEVNEEEFFEYEVEYDDESLICKTNEIKLDNKCYKKAIVGDKCEIDNQCINGASCINNLCYCPKNTAGYKKRCITNICGINNNRIPVLLANSKALLCQRKTCPNGSTCLKSSLINDYVCCSTVNGKGTGNKKIVKKKVLIKKNKNTSTITMEGSRCKNEIMPLLDKNTKTIVSCSNKKPCPKNYVCVKDQCCRSETKIFSGIYMDSPNIILPPKSDVPLCDEDHVLVTYDDNGQSVYSCEIECPDKQSPLDGICISDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDM9</accession>
    <name>A0A0N5CDM9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metalloendopeptidase</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDM9"/>
    <dbReference type="WBParaSite" id="SPAL_0001597300.1">
        <property type="protein sequence ID" value="SPAL_0001597300.1"/>
        <property type="gene ID" value="SPAL_0001597300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733557" description="Metalloendopeptidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="142"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001597300.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58440" checksum="F0C19E338A8BB2ED" modified="2015-12-09" version="1">MNLFKKLIILFILLVFFVDLLDSKKKKKNTSKKKDDKKNIGNETSPLTKNDKKKKEKTTIIIKKKPGRGRDHHRGHDHSHEHVHIDIQIHDHGHGHKPDKPNKKPASKPDKKPSTGPGKKPCKPGKPSGPGIPVKPGEPEIKTTTKPEIKPNITKVIFPVYYCVYLKPGEIYHPLRGVNRTILKEAISQLSERMCLQFVQLVECRNESSFPHPLILFIDDLGTYINQYNFTYPIKFTNPYEIKIQASCNRKVGCFLKKILAYLGSYLTHRRKDRDSYITVNTSNVLDGYENEFDKIESDVYYNVSEYDFGSVMHVSKFYRKNYLRGDPFKTQISSSYESMVGQEYGLSFSDYKILNYRYCRQECLNKLSCKNGGFQSSEGCEYCECPNGYKGNLCEDLEDSTGECGETLLNATSKSEILSIKGRGTCNILIKANDHKKINVTVIKASLGAAYPCFEKKGLEIKHRRDKSVTGLCLCTYAEKVVLESEDNTVFIQYNGFIQNHYANITYQGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDT5</accession>
    <name>A0A0N5CDT5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDT5"/>
    <dbReference type="WBParaSite" id="SPAL_0001602900.1">
        <property type="protein sequence ID" value="SPAL_0001602900.1"/>
        <property type="gene ID" value="SPAL_0001602900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF3">
        <property type="entry name" value="I-BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001602900.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65445" checksum="73DD3E61D41334DC" modified="2015-12-09" version="1">MPKQLAQSTFTGGTDKGKKKAQKKNKTILCNSKIVDNSKCASETKKTPQSNKTNKTDLEKETCSGNVAQVRVNVVNVTEKSSLQKTKKGFTIILNEITPNEWDDCTQQPTKIIPPKLVQSKKPLLSAPIKKAKSHLQNEGLTAKNGKSVSHKIEANEDKKGGDKEDDNEDVADAIDDHGNPKYAKLADIQDESILRELESGMGQSNSSHSVYDRYIKHNKELIYYSPIKGNMKNIRNTLTLGMHIRSTEDIQNYRRQVVEWKGPIILSVFMESREVFSNSSYCAYCRITSIVRSRHKIWAYFIYNNEKSNITQGGLRKYLEDFNCKEANKLAEACNPSPTSLGKKIQEAINYPINAMRNIIYKEAKSDYVVLLESDQYVSSNFYPKMLKLSKRYLKKNTKNALVFRTFEINHPPGYVIKNKKQLNNLINDGDATEFEQINFSVSDKTLKLNEWLRSEEKKEPSIQYHQPYNNGYWEPQIVTRKDIPLYEESFPYPLDVTTEQRREMCRAGYHFLIVNDIFAYHQMDEKTSENILFVASVVQGARVDLVKAQSEFHKKLDSLYPGTKNKCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFQ8</accession>
    <name>A0A0N5CFQ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFQ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001669200.1">
        <property type="protein sequence ID" value="SPAL_0001669200.1"/>
        <property type="gene ID" value="SPAL_0001669200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001669200.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="59345" checksum="9E5852D2FD5B18D9" modified="2015-12-09" version="1">MESPVDVPIIARLAFDAEDKLPEDYYTVLKKEEIKEKAKHFKKIEPDEWVKAKEFVPTSVEKNSKTHDYLTSTFYINQPFNEMVYSFNHEYNPSPYNIPNSNGCNLNYQNNNGFISTYHNPYSRPYRENFSTTSSQSTGSVNSMKRKKRYNNKYKNKKNFTIKAQYRKANEAFNMICSQKSNLPKKSSISKSLNYLLHSSRKNSILQNDGELSIKEETKLICNSCPSLSPEQLNLWNEVLHNMKSIHDKTLNNHKDIETGVNTKNNNDEVNDECIKKDGEIKNNDGLLNTKDESIKQKVMKSSTYERVDVNTLECLDEAAHFNKIRSKDIRLLEKEINGLKMENSFNEETMVERINNLPYQHQKMKNNPAYEQKSLQSELEEIEDLKFKPVITKYGYPQYDNNFLNIHNHMTTYDIHDGHTGTKMINPNFIYHNNENIQVDYIEGWEYDETTFQNPDCNKKHSIIQSTIPTSLWNRMQWLFRQRQFNIQKITPSTEHDNRCCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFX9</accession>
    <name>A0A0N5CFX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein ovo</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFX9"/>
    <dbReference type="STRING" id="174720.A0A0N5CFX9"/>
    <dbReference type="WBParaSite" id="SPAL_0001675900.1">
        <property type="protein sequence ID" value="SPAL_0001675900.1"/>
        <property type="gene ID" value="SPAL_0001675900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009913">
        <property type="term" value="P:epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010837">
        <property type="term" value="P:regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001250">
        <property type="entry name" value="putative transcription factor ovo-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000452">
        <property type="entry name" value="Transcription factor Ovo-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF271">
        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001675900.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38186" checksum="B60A991D9A73FEF1" modified="2015-12-09" version="1">MSAMWFSNDLTSSKVFSINSSLSPYSGIFSLPIPNPKLFNQINENIQNEKCVDIDKNDEKNLKKNNNNNSFMIKSLLSSLMEEEEKKSKMDINIKRLLPMPQQIPTPFPYVSVPVPVPQTSIEYVNGGYGIKNPLLSNNNNPPDVDSTPAPTSSPGEFICRTCGKKFTLQRLLNRHVKCHSEVKRYLCTFCGKGFSDTFDLKRHTRTHTGVRPYKCHHCDKSFTQRCSLESHLRKVHGEIHNYAYKQRRSKVFVCEDCGYTSPNYDEYISHLRVTHPLSAVLMKLANPITPSTSSFTSTPSNWRIQLHHRHPHSHQHHHQHHYHHHQFLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGD9</accession>
    <name>A0A0N5CGD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001691700.1">
        <property type="protein sequence ID" value="SPAL_0001691700.1"/>
        <property type="gene ID" value="SPAL_0001691700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001691700.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24748" checksum="8C37B4036746D726" modified="2015-12-09" version="1">MLSMQLTIVDYFFDFASSSNYSASATVTSQSTTSVTNNFNVVSPNDYASLNKQFNQVIQQIAGGSNISYFNLIVQALQLNLVDSSVYTYNPLLIFFVDSPIVDLNSTTXIRSFINNSGQSKSNTTFLHGAMYILDENQSYLQHKTQMSTFVFLASVSEFEIAQAAQDASNLAYFGKLNIITMGSNIENIALAPLQFSNLINWDYSSGEIRLIQEFVSGNLKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH85</accession>
    <name>A0A0N5CH85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH85"/>
    <dbReference type="WBParaSite" id="SPAL_0001720525.1">
        <property type="protein sequence ID" value="SPAL_0001720525.1"/>
        <property type="gene ID" value="SPAL_0001720525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001720525.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14552" checksum="84305C892938C9C5" modified="2015-12-09" version="1">MESIGVFLVCISVFLGTYYKRDIVNNMLSTILGRRRRRVENQSPNANEGKHPLLPSTPNVINNQNLPAISRSNQSSRDSTLVQQSVQPTSNKPQIPPIQQDPYVQPNQSLRPASYIFPTQPVPYAPYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHY7</accession>
    <name>A0A0N5CHY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal_S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHY7"/>
    <dbReference type="STRING" id="174720.A0A0N5CHY7"/>
    <dbReference type="WBParaSite" id="SPAL_0001744900.1">
        <property type="protein sequence ID" value="SPAL_0001744900.1"/>
        <property type="gene ID" value="SPAL_0001744900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027487">
        <property type="entry name" value="Ribosomal_mL48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="3">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001744900.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21561" checksum="88ABF2A5087075A1" modified="2015-12-09" version="1">MLSARSCMTKQIRSFASLRDKAIKIDPKYLRQPEIKDHRKYPEYPQISVILQGYDYAPLELFQSYVHRISGRFKFNVVESYAVPGKRERIVLYKPNSSVIDKEYLLTLYQRIIRIENIPSVKLQLFAQILRTHIPIGVDITIKDFTKEDDNCRYIPDLLLKEKQDELKMLDDPIIRKNLGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIP2</accession>
    <name>A0A0N5CIP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inhibitor I9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIP2"/>
    <dbReference type="WBParaSite" id="SPAL_0001769700.1">
        <property type="protein sequence ID" value="SPAL_0001769700.1"/>
        <property type="gene ID" value="SPAL_0001769700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895929" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001769700.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16718" checksum="D5A059B030DD0478" modified="2015-12-09" version="1">MNYLKVVILIFTLINISFGYKTDCNSILPISCTFYLTPDEDAYRSTLLRSLNSKLKNIYDLGLDSNESDENKIEEVNKKLQTVLDDNTINEFLENLSGFGKRGYGVRVMLVSKSIYDYLQSDYTTKKPTTVMSMSNIHHMSKNSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIS2</accession>
    <name>A0A0N5CIS2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIS2"/>
    <dbReference type="WBParaSite" id="SPAL_0001772700.1">
        <property type="protein sequence ID" value="SPAL_0001772700.1"/>
        <property type="gene ID" value="SPAL_0001772700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001772700.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8138" checksum="59079B787FDD94B7" modified="2015-12-09" version="1">MEFVNNFLKKVNKIDIPKDPNCGTVDSGHHNFRRDFVRSSHVTVLNGNVKLTCVLDINAIVYSIIINIKNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2E4</accession>
    <name>A0A0N5B2E4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2E4"/>
    <dbReference type="WBParaSite" id="SPAL_0000025100.1">
        <property type="protein sequence ID" value="SPAL_0000025100.1"/>
        <property type="gene ID" value="SPAL_0000025100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000025100.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19019" checksum="121B961C6B6F3BCD" modified="2015-12-09" version="1">MTGETSHSKKAYQSNDSLFDAKFTGSGIKIVASKDEIGIPNKKYTFGYDNEGTFYADSNKSYQYGFYDKGRFTPFNNSPIDEYKGAFGYLYRGTFYVQKTPTEYCYPKKYQFGYVDNGLFISLQKFQDNQYDLSQTIPERKYPKSKVPVSSDDDNQVIDLTKHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3N1</accession>
    <name>A0A0N5B3N1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3N1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3N1"/>
    <dbReference type="WBParaSite" id="SPAL_0000068400.1">
        <property type="protein sequence ID" value="SPAL_0000068400.1"/>
        <property type="gene ID" value="SPAL_0000068400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="3">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000068400.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9896" checksum="8DB849D1C2B2BFC0" modified="2015-12-09" version="1">MMSKRDIRAIMLYEFKRDTNAAKTAQQIKETFGRSNEDLGNEERERPESVLDNDVPREAVEANPLTTVREFAKDLNVSKSTVSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B421</accession>
    <name>A0A0N5B421_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B421"/>
    <dbReference type="WBParaSite" id="SPAL_0000082400.1">
        <property type="protein sequence ID" value="SPAL_0000082400.1"/>
        <property type="gene ID" value="SPAL_0000082400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000082400.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43333" checksum="BE751D1051EA93FE" modified="2015-12-09" version="1">MEHKCKITKEEKIKVAVIEGVIDDLRPDHKYKSLIVQELKKYQIAEKHLLNIVQICINCTESVIGAYSVKEEAKTKEKGVLGNSGTEIFVIEKKMTSQLTWSASLPIFDPRKKSFEKYLVLLEEAFLLDDLDNERKKMAIVKLKSTEEVRAYIAILPKPITFKVLCERLTANFNSIANKTNVKVQMRHFKIDLEKLHSNILQCMDLVARSTTRVNNELFEYQVECLMDKLSFNKMLFQRMVDSTHRYENIYDIAADIENYHKNMSKMRISNASFSENPERKRSSVTCYRCKKISHIASQCKEENVVKLEDVKLTLNAQSKECKVQNVMHENRVVDSWEPIIYMKDEIREKAMHAAGLQHSEEKIRCGTTLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5A6</accession>
    <name>A0A0N5B5A6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5A6"/>
    <dbReference type="STRING" id="174720.A0A0N5B5A6"/>
    <dbReference type="WBParaSite" id="SPAL_0000125100.1">
        <property type="protein sequence ID" value="SPAL_0000125100.1"/>
        <property type="gene ID" value="SPAL_0000125100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000125100.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24867" checksum="F1216D5B244B61AE" modified="2015-12-09" version="1">MPSNNMLIVPSQFSDEEKKLKEKFEFFKQFKLQTSTEKVPSKKPLSTGVSLDDNGKRGQKRSVDTSQNCTAADIARLINSGELKSQKRETFKRSKIVGNKRVIETVAFDSKRDEDKKLSDGEINSPTRSPDLSHETQSTERKRSGVTSNTAYIRGSNLIYSDVKEACEVYGNIIKIYIPQDKKSAFVEFDNRESTEKAVAGLNLKVISGSTVRTNFARQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5F9</accession>
    <name>A0A0N5B5F9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5F9"/>
    <dbReference type="WBParaSite" id="SPAL_0000130100.1">
        <property type="protein sequence ID" value="SPAL_0000130100.1"/>
        <property type="gene ID" value="SPAL_0000130100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000130100.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="28394" checksum="B66E31772EBC5DE2" modified="2015-12-09" version="1">MKEDDDSDNDIEEIENNVQLDLVKKIMLPYITEEDVLNKMLNFEIKKNFNADLAAAKELLLTKEQEDHLKYYSQGLCHVMNSFLYNVYTTRIPQKVRLRKFAVNAYLKLVKNLWGLPVFDFNVKKFGQVYRQRQSRAKRNIVKKTPEKMPPSPFLNPLIYIEKIKTARKFCYKVFSNQSMNSFIRKNYENMYFYLSTTMKNIDIMPQTLQKREIISINKVSSGIDKIKEMFISENHTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5G5</accession>
    <name>A0A0N5B5G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B5G5"/>
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        <property type="protein sequence ID" value="SPAL_0000130700.1"/>
        <property type="gene ID" value="SPAL_0000130700"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001253500.1">
        <property type="protein sequence ID" value="SPAL_0001253500.1"/>
        <property type="gene ID" value="SPAL_0001253500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000130700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001253500.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19727" checksum="1AB346E7B739FCB8" modified="2015-12-09" version="1">XFVCRVVLVRKKDMKWRFVVDFRAINKLIKQQSHLIPRIDRLTEEASGHKYYSVFDLKQGFHQIPLDEHSRRIAAFVTHRGIYQYKVMPMGLTGSPDKFQDIMDKVLSNIPDCYIYLDDILTCSQDEESHIHNIDNILSRIAEYNMKITLNKCQFGQKKCSIFKIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6I6</accession>
    <name>A0A0N5B6I6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides.</text>
    </comment>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6I6"/>
    <dbReference type="STRING" id="174720.A0A0N5B6I6"/>
    <dbReference type="WBParaSite" id="SPAL_0000167500.1">
        <property type="protein sequence ID" value="SPAL_0000167500.1"/>
        <property type="gene ID" value="SPAL_0000167500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000167500.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12843" checksum="BF43186AA849A6EA" modified="2015-12-09" version="1">MFTRDSEFCGRCNTFLVYPSLAPSKVQCPQCLTKWKFNAINNLQVTSAKTVYMKSIANTEDSTTDTGDAIVEHVCPRCENNEASYTTLQTRSADEGATIFYTCTKCKYKCIEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7C0</accession>
    <name>A0A0N5B7C0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF753 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7C0"/>
    <dbReference type="STRING" id="174720.A0A0N5B7C0"/>
    <dbReference type="WBParaSite" id="SPAL_0000194600.1">
        <property type="protein sequence ID" value="SPAL_0000194600.1"/>
        <property type="gene ID" value="SPAL_0000194600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF18">
        <property type="entry name" value="BOUDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894001" evidence="2">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000194600.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30401" checksum="4D9B6A202C863C62" modified="2015-12-09" version="1">MCHNKAFFMIFLLKLSSEIFFCDAIKCTSCASKELEVNWSATTLMYPKNTTYFFDSECDRINSPYIEPKCSSYCFSMLVNSNSNFYIVRGCMDDFFNNTVINDVKGKLDEQGEYCLESEEKTPVSDKFYLRYCSKDGCNNNFKVKEFNEVCKSTLPGNNTCYSCNNLYGSGKCKPNSDSTCTGKYCVKVSGHYGEAKFEERRCSNVNPYIKNTCIETDTEFPLSLTSSITANEVIKSTVCYCEGNFCNSSTSRYISMISLLLTIIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Q8</accession>
    <name>A0A0N5B7Q8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Q8"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Q8"/>
    <dbReference type="WBParaSite" id="SPAL_0000208200.1">
        <property type="protein sequence ID" value="SPAL_0000208200.1"/>
        <property type="gene ID" value="SPAL_0000208200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000208200.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45719" checksum="4AAB3B690164951A" modified="2015-12-09" version="1">MAGTCQPLIGMYWNNQTVNPESGFYGYLFKASTIQNFADGSFFTIFPTKLEYRASSDQSGDSLSQTRLHSEDQFTNTLEGNEMNCQDVKPNIHNISNGNSEDRHNERTSNGVTITDEIRFSIIEAIQLRPCIWDNSSKEARSHLSRKDNFMEVAQHLNSLGHPLSTLDVEKQWKNLKDTYNKVKKKLILDQHGNMVPPKWRFFSAMLFLDQADNYQTTQQQQMNNIMLTTPTESRKRRHNMESPSLSLQKMSKTDMLGQLPCSEIDMQPMSHEDLSVPSSSTTPQTIRCTIPIATNLYKTHSADNSTTTTTTPRGGYTNHHQSLHHSQFFASNAVIDDEYSSFCRSLVFSLREIGSTNRLQYLKVQKAIRDTIHEAQVQCIMSGGQQCNNKMSSNPNNQGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8I4</accession>
    <name>A0A0N5B8I4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8I4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8I4"/>
    <dbReference type="WBParaSite" id="SPAL_0000235700.1">
        <property type="protein sequence ID" value="SPAL_0000235700.1"/>
        <property type="gene ID" value="SPAL_0000235700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000002">
        <property type="entry name" value="alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="4"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000235700.1"/>
        </source>
    </evidence>
    <sequence length="969" mass="108560" checksum="45304D58469E7F44" modified="2015-12-09" version="1">MKFMSGNDVRRTFIDFFKEKEHIYVHSSSVIPHDDPTLLFANAGMNQFKPIFQGVVDPNSDMAKWKRAVNTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICEWAWELLTKVYEIPADRLYVSYFGGNEEYGLEPDNECKNIWLNIGLPENKIIPFGMKDNFWEMGEVGPCGPCSEIHYDRIGGRDASSLVNADDPMVVEIWNLVFMQYNREEGGILKPLPNKHIDCGLGLERLIAVMQDKVSNYDTDVFQPIFKAIEEGTGVRKYTGLVGDDDKDGVDMAYRVVADHIRTLVIAIADGGSPDNVGRGYVLRRVLRRAIRYATEKLCAKPGFFSSLVDVVVNLLGETFPELKKDTETIKDIINDEEAQFLKTLTRGRTLFQKAVKALPENEKSFPGDVAWRLYDTYGFPIDLTQLMAEEYKLTVNMEQYEISKKKAIEISAGSVGKFRDSLDMNVHAIAELQSRGIPPTDDSPKYHYSDNGCLGLDGKYIFEKCTGKIVAIRKDGEFVESLTSGDEGALILDRTWFYAEQGGQIYDTGVFVKVGDKDTEFNVKNCQVRGGYIIFVGETEGNLKVGDEVEQYVDEDRRCSIMKNHTGTHVLNYGINRVLPGIDQKGSLVAPDKLRFDFTAKGALTKEQVKNIEEISQALINTNKPVFAKQAPLNEAKKINGLRAVFDENYPDPVRVVSVGTPIEKLLENPSSDVGLNTTVEFCGGTHLKNVSHIGSLVITTEEAIAKGIRRIVALTGLEAEKSLHRADRIEKRVNELKELVEKDENVVNDKVKFKELTKATNELLLEVNSMVLPYCRKELIRETTKNIQKTLDKYSKNAQAAAAQKIVDEAKKLVESIDENTKFLVHVFPEGANGKVLDTALKQIKKPSAVMVFSINNDVGKLQVICKVEKDLVSKGFKAQDWINKVCEVIDGKGGGKDTQAQATGNRLEKLDEAVDVAKEFATLSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9F0</accession>
    <name>A0A0N5B9F0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9F0"/>
    <dbReference type="STRING" id="174720.A0A0N5B9F0"/>
    <dbReference type="WBParaSite" id="SPAL_0000266600.1">
        <property type="protein sequence ID" value="SPAL_0000266600.1"/>
        <property type="gene ID" value="SPAL_0000266600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000266600.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54990" checksum="744AEB116971C9D1" modified="2015-12-09" version="1">MPEEGGAKKGDNKQGKALKPSVDATNNLQADHLTPVLPLQNDAGEEDGPINLQLGTMVAKKYQIIDKLGEGGCGSVYVVKDTTTQIKYAMKSESLKVGEYSVLKLEVQVMKRLGNSSNICQLITSGKNDRYSYMVVSLLGHSLFDLLTTYREFSISTSARAAIQALAGLKQLHDVGFIHRDVKTENLAIGKDNEKRIVFLLDFGLVREYFFVDNNGKVGIRKPREKCQFRGTLKYASIAAQDGGEQGRKDDIWGLLYCVGEFFKRLPWDIDDPDKALVKKIKKETPLQSIFKNMPEMINLGGYLDTLTYYSRPDYKKIYSFFKIEMDRVNAAFEDPYDWELDHRNVPEQLAAAVAKRLKGKDPEEPLPPSNNNVGHVEKKITPIKKGKDSKNVGGAKKLFYNSKDVIFSLQRRFKNSKRKRNRVSVDNQIINDNNVIATVTSQKEIETDEKKEEKKEEKISVPEIPKPSNESPNFYENELGKNDIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9M2</accession>
    <name>A0A0N5B9M2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9M2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9M2"/>
    <dbReference type="WBParaSite" id="SPAL_0000273800.1">
        <property type="protein sequence ID" value="SPAL_0000273800.1"/>
        <property type="gene ID" value="SPAL_0000273800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="275"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000273800.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="74403" checksum="DBF0BCC07AA90E85" modified="2015-12-09" version="1">MENNPQMSRSIPGRFVAIGNNPNIYLTGAAPNAQRIPVTSNKSTTTNHLTVVDHNIPPRNKTSIQSILDVQMAQPRLYFYDEFCVIRPWDRNYRIIYRIDKRNNKSFAFLQHTLPITITPSILQIIGTKNGDVEYEVLLRSIALRNGVLQEKDSYPLDMELFIGNMNYTCLLPRIEAKYSSSDIGLRLGYPSVLTQAISSFNKSNPKQIPLDLVVNIMYPVQAIRKQVINNGHFSFKIALYSKKSPESVVMDILKRPMLPKSAFHENIKKEFNRDDDEVGFESMRISLQSSITMCSIKYPFRGKNCKHLIPDDLEDYLKQNVGNEKFQCKICKCRCTPDDIFIDEYYQEILKKNPKTCKIEIFLNGEYKIVETNDSDDEECGDQIIPSKGSKEPEYIIIDSSDDECEVGENPAPSNSTGNEVSVERQQVVDVPESEQESSREILRENGNVVGSSDEVNTTPLSNEVSTTPLSNEVNTTALSIEVSATPLSNEVNTTSLLNECNNTPSSNEENPAIVENPIDNGPASNNTDTSDSMDVVEASVVVDQIEVTNDEVVISRVEVTRQEVIGENSNEVEIQENNSLQNGGNPVEDIPMEVDEIQVPRTEISKDSAAVTNECITNKLEKLIKSNNNYSFFRKTKEYVELNKAQFRRDFHPGDIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAD5</accession>
    <name>A0A0N5BAD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000300500.1">
        <property type="protein sequence ID" value="SPAL_0000300500.1"/>
        <property type="gene ID" value="SPAL_0000300500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000300500.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="72629" checksum="34DFC9E76A469E7B" modified="2015-12-09" version="1">MSQQGHQQKGKIDEIKKIALSISNKNKNISLELLKNLQYRQFVDRFMEKCKNYLEGSSSDDAKLILSAMWNYGVYGQAKFLRSQMLSVDDKPYFIQFFQNAINLFGEIVQSYPSLDYQCRMKMGDLCRYVYDIDKDNKIYIERAKCYYEMLYKTNMENGHVLNMIGLVQIELKRPLHALQIFFRVHIKFSNYNNGIENARQCRPTSDREMENDFVKKVVLFLKSDMDVDTMQFSQFIPPYVSQTDVEALFDFYLTTVLLTKISLFQVVRKESNETKDQKSIIFMIQTTNEFTQSILSFLSKQPLDTTEKGKALQILLCCCMIDYFDLFFNLAPIQELKIPPLEKDNVNKLAYQFCDCANIIFGCNLEKISKMDWSKKMYFWNTRHPSITQHLNIAMAVSACFINEIRRNVNSSIVVNNDHFAVKDNCLSIGGINGESISRAYFRHVEKVRFAQTMIPAYLVPTEDVFIHHLGFLKYMKNKNNVKICVDPYVVRALDSQKNFDRGARSALSWLDENEKDIIHFDNIYVFPKDFPEVTSNNSQSLRSMVCNSERFLKKIGNPTGSEYVLAVLMVYRDDCGRISTNENMQDYSYENSIIHVDNSGILITTIMKFKHLIDLVNPNSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAK5</accession>
    <name>A0A0N5BAK5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAK5"/>
    <dbReference type="STRING" id="174720.A0A0N5BAK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000307200.1">
        <property type="protein sequence ID" value="SPAL_0000307200.1"/>
        <property type="gene ID" value="SPAL_0000307200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="8">
        <location>
            <begin position="733"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="9">
        <location>
            <begin position="849"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000307200.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="106906" checksum="E7DF8D9FD55BB6B3" modified="2015-12-09" version="1">MTDSKYFTTTKKGEIFELKNELNSDKKEKKREAVKKVIASMTVGKDVSALFPDVVNCMQTDNVELKKLVYLYLMNYAKSHPDLAILAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCMKDEDPYVRKTAAVCVAKLHDINPSLVEDQGFVELLSDLLSDSNPMVVANAVASITEINQTKPLFEINLQLVNKLLTALNECTEWGQVFILDALNNYTPRDEREAQNICERISPRLAHANAAVVLSTVKVLMKLMNYLPENSEFINQLTKKLAPPMITLLSAEPEIQYVALRNINLIVQKRPDILKQEMKVFFVKYNDPIYVKMEKLDIMIRLAQQSNIAQVLSELKEYAAEVDVDFVRKAVRAIGRCAIKIETAAEKCVSTLLELLQTKVNYVVQEAVVVIKDIFRKYPNKYEGIISTLCENLDTLDEPEARASMIWIIGEYAERIENADELLESFVETFHDESTQVQLQLLTATVKLFLKKPSESQDLVQRVLALATQDSDNPDLRDRGYIYWRLLSADPAAAKEVVLASKPLISGETDFLEPSFLNQLINHIGTLASVYHKPPSSFIDTSRQPLKKLGVPSSESNDESGDILSFGNGGASMRTGPVIPSQDNIIVDLLSLDINPTPTIPPQNSVPTTSGLDDLLGLGNLSINNTNPPPTTSQPVTNDLLSDILGSSTIPTMQTQPPSTFGGVDIFGTSTMNTLNTFGGFDVQSSSSPYMPPKSLWLDSNAGKGLEVQGTFVRRNGEIYMEMTFTNKSLIPLTNFALQMNRNSFGLVPAVPLYVPSPLQPNQSENVTLHCKVGGGVLKMDPLTNIQVAIKSDNGILYFSCIAPLNIYFVESGKLEKAEYLQKWKDIAQTNEVTKQLSNTKLLSCDDICKKLEANNAFVTARRQDNDKDILYISIKYTNNVNVLCEMTVQQGSPTITLSMKALFAPALSTLDQCLQEIIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAN6</accession>
    <name>A0A0N5BAN6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAN6"/>
    <dbReference type="STRING" id="174720.A0A0N5BAN6"/>
    <dbReference type="WBParaSite" id="SPAL_0000310300.1">
        <property type="protein sequence ID" value="SPAL_0000310300.1"/>
        <property type="gene ID" value="SPAL_0000310300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106279">
        <property type="term" value="P:negative regulation of UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000023">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="69"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000310300.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="45589" checksum="1FA139DA34F0B552" modified="2015-12-09" version="1">MMLVDYSSPILCKPNPGKIIQFTNCKIVLGQDIVEGDLWTLDGKIIDGKKVFFDKKEFADIKVNCKGLIISPSFIDVQINGAFGVDFSSLTKYNFINGLIFVAEKLLSFGVTSFCPTIITSPSQYYHDVIPLMKFRKEQIDYTKPRANILGLHLEGPFIAKSKKGAHPERHIIDSFLPNPLDTLINIYGPHLFDGDVNIITLAPETKGSKEIINYCSSKNIKISLGHSDCTILDGEEAIKNGAVKITHLFNAMKNYHHRDPGLIGLINTPTINKNLFYGIICDGIHTHPSAIKLAHQANSNGLLIVSDAMAALGMGDGIHRLGDQTISVKNNHATVDGTNITAGSVASIPSCVKTLQNITNCSLSSALQSASFKAAKLLGISNMIGDLSKIGSNGDFILVDEDVNVHCTFINSVKVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB13</accession>
    <name>A0A0N5BB13_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB13"/>
    <dbReference type="STRING" id="174720.A0A0N5BB13"/>
    <dbReference type="WBParaSite" id="SPAL_0000322700.1">
        <property type="protein sequence ID" value="SPAL_0000322700.1"/>
        <property type="gene ID" value="SPAL_0000322700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000322700.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55112" checksum="A38994AC59841E0E" modified="2015-12-09" version="1">MVCPGAAEGLKAYEKMGIPPPVVDLKPTYTKLFINNEFVDGVNKKTFDTINPSNNEVICSVAEAEAEDVDRAVAAARAAFKLGSEWRRMDASKRGVLLNKWADLLERDKSLLASLESLDNGKAYKVAFTVDLPFSIAIIRYYAGWADKNSGQVIPVDGDFFTYTRHEAVGVCGAIIPWNFPLLMAVFKIAPALATGNTVVLKASEETPLTALHLASLIKEAGFPSGVVNVIPGYGPKAGEALAKHPDVDKIAFTGSTAVGKLIMEFAAKSNLKRVTLELGGKSPNIIFDDVNIDEAVVQAVDGIMFNHGQCCCAGSRTFVHAKIYDEFIQKAKAYVEAKKLGCPFDPTVDQGPQISTKQMKTILSYIESGKSQGAKLITGGERFGEKGCFIEPTIFADVTNEMKIAREEIFGPVMAIFKFEDEKDLVEIANDTIYGLAAGLMTNDISKALYVANSMRAGSVWVNCYNVTSAAAPFGGFKMSGIGRELGEYGLQAYTEVKTVTIKVPQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEA2</accession>
    <name>A0A0N5BEA2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEA2"/>
    <dbReference type="STRING" id="174720.A0A0N5BEA2"/>
    <dbReference type="WBParaSite" id="SPAL_0000432500.1">
        <property type="protein sequence ID" value="SPAL_0000432500.1"/>
        <property type="gene ID" value="SPAL_0000432500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="20">
        <location>
            <begin position="42"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="21">
        <location>
            <begin position="492"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="436"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
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    <evidence type="ECO:0000256" key="19">
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000432500.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="70385" checksum="076FF2B55C894EF0" modified="2015-12-09" version="1">MLKAGTCGFKSVTQRALSLSAANACAKRGNVSDYKVIDHTFDAVVVGAGGAGLRAAMGLAEGGMKTAVITKLFPTRSHTVAAQGGINAALGNMNKDDWRWHFYDTVKGSDWLGDQDAIHYMTREAPRAVIELENYGMPFSRTEDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQYDCKYFIEYFALDLIMDKGECVGVVAMDLEDGSIHRFNAKNTVLATGGYGRTYFSCTSAHTCTGDGTAMVARAGLANSDMEFVQFHPTGIYGAGCLMTEGCRGEGGFLVNSEGERFMERYAPVAKDLASRDVVSRSMTIEIMEGRGVGPEKDHIYLQLNHLPAEHLAQRLPGISETAKIFAGVDVTKEPIPVLPTVHYNMGGTPTNYKGQVITYTEEGGDKIVPGLYAAGECAAHSVHGANRLGANSLLDLVIFGRACALDILAKNKPGDSIKPLPKNAGEETIARVDAARFANGDITTADLRLDMQKTMQNHAAVFRRGDILKKGCEKIADLYKKQKHIKVSDRGLIWNSDLIETLELQNLLINAQQTIVAAENRKESRGAHARDDFPNRIDEMDYSKDTSNQTPKPITEHWRKHTIINQNTETGDVKLTYRPVIDATLDKSETDWVPPKVRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF07</accession>
    <name>A0A0N5BF07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF07"/>
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        <property type="protein sequence ID" value="SPAL_0000457700.1"/>
        <property type="gene ID" value="SPAL_0000457700"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000457700.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39293" checksum="CA7A3EEB1422F31D" modified="2015-12-09" version="1">MPYFEYMKREFYVNADPGISLTQFFLRNQPAELRTTFYSMYEGNLEDITEEEIESFCMKFERKANKTEINKLMDILDLKRGISESPMGYLARLKLMVVRISNIHDMLPEDAFILAKLLNEIPKPICADLADEYQLNPTIVCEMWETYLKRMTINNHFLKQSNPGYNVNGTTRGNGGMNRVTNSRFTSNNTTRYNAVDSYNDKRNGIDGRAFNNHDDKLYRGNQNQRRDDYVTNIVNMYNERKHDSMNDTKKNDERYPRSAEVFQPNAREPVVNNQENRQGGKTIFCYVCGDPNHYASRCPNRKQEQIVSKIINQKILKIPNTYQQSPTIRTVLMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG13</accession>
    <name>A0A0N5BG13_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG13"/>
    <dbReference type="STRING" id="174720.A0A0N5BG13"/>
    <dbReference type="WBParaSite" id="SPAL_0000492100.1">
        <property type="protein sequence ID" value="SPAL_0000492100.1"/>
        <property type="gene ID" value="SPAL_0000492100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000492100.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51745" checksum="79D6DA00184A94BE" modified="2015-12-09" version="1">MSAISSFARRSLLVSKNVSPLFSAQASMCSETTNLKEVLAKKIPEHNKKVKDFRAKHGGDKVQDVTIDMIYGGMRSMKGMVTETSVLDPEEGIRFRGYSIPECQKLLPKAPGGEEPLPEAIWWLLCTGDIPTDKQVAAISKEWAARAELPEHVVRMLDNFPSNLHPMSQLVAAAAALNSESKFAQAYANGVHKSTYWEYTYEDSMNLLAKLPTIAAMIYRNLYRDGTSVGVIDTKKDWSANFASMLGYEDPLFTELLRLYLVIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAAMAGLAGPLHGLANQEVLIFLSKMTKDLGTSYSEEDLRKWVWNHLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDDLFKLVSTLYKVTPNVLLEQGKAKNPWPNVDAHSGVLLQHFGLKEMNYYTVLFGVSRALGCLSQLIWARGMGLPLERPKSHSTEGLMKLVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHS5</accession>
    <name>A0A0N5BHS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHS5"/>
    <dbReference type="WBParaSite" id="SPAL_0000551000.1">
        <property type="protein sequence ID" value="SPAL_0000551000.1"/>
        <property type="gene ID" value="SPAL_0000551000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000551000.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42568" checksum="05DE613D71ECF429" modified="2015-12-09" version="1">MERKVTKFPCPRWHVDDIFNDGKVINKNEPVEGYNVYPYVTSFKTFGILCTYLIMLSYLISWVSYTWNKEELKYVLHDRAHVKYGNMFFKCYIYENDESGVIPSLFNLRLLVPFPNYFMRISVLTLIITRFFISFGHHIGAKIRKDKIISELSEREGKIAKIDKLKGYGKFYGKIIPLIPVVFLFELLCFAMVLIIHPALDSKLIYKSFFISYLFFSICHMILIVRSNMYKLEYNKFDKRLLSCQMVATILYIVSSPVTAIYHLSFASDILCHPLVSLDAFLMELLMIISYFAFHLSLMYDVKDIDFVFMATKDDLYFEVTNGCEDKYFPEMYREYCEENQVRKELKAVEENNNRIKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIH0</accession>
    <name>A0A0N5BIH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIH0"/>
    <dbReference type="STRING" id="174720.A0A0N5BIH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000575400.1">
        <property type="protein sequence ID" value="SPAL_0000575400.1"/>
        <property type="gene ID" value="SPAL_0000575400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="279"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000575400.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="89217" checksum="6359346D9D24DE58" modified="2015-12-09" version="1">MSEFQESMEAMRETIMALSPDERERFRRELSSEEAVEFYDIIVNELHDNEENGGGDLKEKFTALMNMRGKLNISHLIEQTKVIEGDQEFMNDFLAIVGGGSTSKETREQLKKEIGKPNINPPALAPEFKKWIKRSKAVNAREEKLSDLTSFMLMAGILLSKNERKSHEELAKILAHATRLVIDLRRKNLFEFFNIPTEREEVVTWSDEILSQNEKDRIKEVRKENGLKMIRYNAAKYTNSRIYPPYNQRYVFWKSITDDEYVLKIIREGYRIPISEFPHPCRCTTYEKYFSDSDNEFITKEVQRMQDEKIISPLSDIELENCRYHLNPIFVHHGTKKDRIIVDCRNLNSVVKVEKFTYESIEFVSSLLYSKRLFVTSIDLSSAYHAIYIHKDSQYLLCFKFKGRVYKFHRLVFGLSTAPYIFQRILKVPLNKFRERSSILLSSYLDDIILIAEERSNLHEETKALCQLLNKCGFSINYIKSVLEPSRELEHLGYIINLNNNCIVVNNKRISKILNLIDDIINRKRISYRKLACLLGTAISMKFVYDSIMLYITPLYGVLTYGLIELKKSYDSMVSITKKEIDALKDLKTYVVKNRGVPVIHDIKEKFVNVLTDASNESMGIYIREFDVKISRKFGKIERDWHINIKELHAIKISMDILLEELRIRKIELHEVNIVSHCDNMTARSWVLKKKGDSELVHDIVHKIVTCTSARPQFSSGSFEQGYGVNISPYRSPMEFNGAEFNERKRRNSKGWPSHPKNKKVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIJ1</accession>
    <name>A0A0N5BIJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BIJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000577300.1">
        <property type="protein sequence ID" value="SPAL_0000577300.1"/>
        <property type="gene ID" value="SPAL_0000577300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="46"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000577300.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="59752" checksum="9B0812155EC805F7" modified="2015-12-09" version="1">MNSTIFSSEENEMVGGIEDSLHQLSVYELALWCFLYTVIAFLAVFGNVLVMYITLKPLYNRSVTSLLIINLAVADIITGILAIPFKFHAALFQRWFWPDMFCKIVPFIETLSLSVSVFTLCTSALSELSQLYFINIGAMNLHSARKLIFIIWLLAFIVSLPYGMFHEVIKFKLSPTSNDEIRQCIPRYGDENWWKAYNIYLTIIHYFVPLVIVDSAYTIIAISVYRDTQQEKNLTSFMKKISQCNDDIGKRHTFTKEKEFKNGDINSFSDLQQSIKFPVPSEQSVASINYINNNSTVKSRRKIVTMLILVVTFFTLCWLPLETYLLLNEVQPQINEWRYINVLFFCCHWLAMSNSCFNPIIYGLYNDKYKEEYRKIFNRFFGICFKNLQNRHRRYHKCGKKYSLHSRIVIKNITNKPNVVLFNYNQENECIKKGKSNESFQSIESSMKILSSFENNLKCDKKFYIQSDDSLKHLPFKTSIIGNKIKKPLKTQQSLLNEKKEINNEDLFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIN9</accession>
    <name>A0A0N5BIN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000581900.1">
        <property type="protein sequence ID" value="SPAL_0000581900.1"/>
        <property type="gene ID" value="SPAL_0000581900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000581900.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14100" checksum="6B0479F50EF979E1" modified="2015-12-09" version="1">MSFLRRNGKRTINAKCDVVKVINKVKQVTLCHVFLRRLVTTFGRPKILLADLQPSFNAKRYAKFINNLAIRLVINKAEGNRGTGTLIKRVSRNLTESLAKMNIMAKKIFLKQNSLFFGDSITGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJH8</accession>
    <name>A0A0N5BJH8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJH8"/>
    <dbReference type="STRING" id="174720.A0A0N5BJH8"/>
    <dbReference type="WBParaSite" id="SPAL_0000610400.1">
        <property type="protein sequence ID" value="SPAL_0000610400.1"/>
        <property type="gene ID" value="SPAL_0000610400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000610400.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19008" checksum="53318E347E49FFB7" modified="2015-12-09" version="1">MTRPKVFFDVATQTSKLGRIVFELYEDVVPKTCRNFRALCTGEKGVGKFGKPLHYKGSTFHRIIPQFMIQGGDFTHGNGIGGESIYGEKFADENFTFTHSSPGLLSMANAGKNTNGSQFFITTVETPWLDGKHVVFGKVVEGMDVVKSIEKLGSRSGTPSQKVTIEECGECKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK50</accession>
    <name>A0A0N5BK50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK50"/>
    <dbReference type="STRING" id="174720.A0A0N5BK50"/>
    <dbReference type="WBParaSite" id="SPAL_0000631500.1">
        <property type="protein sequence ID" value="SPAL_0000631500.1"/>
        <property type="gene ID" value="SPAL_0000631500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052861">
        <property type="entry name" value="BPTI/Kunitz_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248:SF7">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248">
        <property type="entry name" value="PROTEIN CBG06772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000631500.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26731" checksum="98707DE9F33EB19D" modified="2015-12-09" version="1">MTIITMNLFALIFIALIYTIYCGMLPKIKYEPWMLENMPERTRFTDVPKCKLPPDTGEYCDGSNTNTTSRIVYYFDPEMLECYPIRYKGCMGNENMFDDKEDCKSHCLKSDYDGCRGGIEPSEKMCGWNSTCEQENLNKTEHYMCSNDYMLVIGKKYDHCCYKTSQLFLKSKEDLVRCMGGNFSKGTPVRLDTIEYHPVWLLGRSCSHDFCPEKTICQQGDLFAYCCYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLA8</accession>
    <name>A0A0N5BLA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLA8"/>
    <dbReference type="STRING" id="174720.A0A0N5BLA8"/>
    <dbReference type="WBParaSite" id="SPAL_0000670700.1">
        <property type="protein sequence ID" value="SPAL_0000670700.1"/>
        <property type="gene ID" value="SPAL_0000670700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053302">
        <property type="entry name" value="CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159:SF6">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159">
        <property type="entry name" value="PROTEIN CBG07705-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000670700.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43085" checksum="A805EA1EE1482324" modified="2015-12-09" version="1">MINDIEKIRNDMGDEIPKYMNTDYHLKRWLKANNDNVNDTIKKFRKYLRIRQCYKCDDDKYFEDFYNNTEIVNFRKIFSQSICQINWYNSKDNALLFVESAVNDTGSVTKSIRVNDYVRIFFICCEYFQRVLLEHEKITGKESSGICIFDMSNFSLMNYANPVSAINKMYETRIDIWLNYFSELLKKVIIVNGPRIMSLSWKVLSILLPSEVHDRFMFANSLPHDLEKSLSTDCIPIAFGGTKHIGNCLPNCCNVVGKLMAKDFIKNGDIWLKEKVIPPKAKNISLSPGDVLKETFEVKKNQKLIYELYCNKDYTLKITLNDNILLNPDIKLSTPVLSAEDSFTIPISGIVLLELTNLSKLMKMSGKLTVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLJ3</accession>
    <name>A0A0N5BLJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (guanine(10)-N2)-methyltransferase homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BLJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000678900.1">
        <property type="protein sequence ID" value="SPAL_0000678900.1"/>
        <property type="gene ID" value="SPAL_0000678900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000678900.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51168" checksum="93D6C42BC8E9342D" modified="2015-12-09" version="1">MPSFLFIFSQVHGDFRASEFKAVCDLFNIPFDESLINKNEHIYELNFESLSDVEKILSRVMLVKYAIELFAKADNYDELHKKIKKNLEVFEKYNNENQTFCIRIRPLGKKRDQNYINNVVDIFGDYLPLQNCKIDLVNPVNCFTVVEDYNSNVKGYQLNMIYFGRFINFGQGQLKTKYNLKDRPYIGNTTMDPELSFIQANLVLAKKGSLAIDPFVGTGGLILPLAEFGCYVTGTEINYQIARCIGKSSRVGEGMLTEKNTHRANFEKYGTFEKFLYHCHADASHHSLWRLQKNGEGVFDIIVADPPYGLREKGRKIGKKDRKEHWTLPGQVHMEHFPEKTKYDIKTMYLDILNMAARNLVINGRLGFWFPVFPAEYTIDVIPNHPCLKLVSNCEQPLGLKYSRRLLVYEKIKNVMLDEAAFVIRDMFESETVRERIFVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM26</accession>
    <name>A0A0N5BM26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM26"/>
    <dbReference type="WBParaSite" id="SPAL_0000697100.1">
        <property type="protein sequence ID" value="SPAL_0000697100.1"/>
        <property type="gene ID" value="SPAL_0000697100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000697100.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37781" checksum="924E6E1DAA237087" modified="2015-12-09" version="1">MIKRIEQEFRLLIDEKKDIFDEETRKHFLHKLNTMKFVKNHDIYGLSDVHLMKYCYENIGINYNNHIADILKTIKHYRALSYDCEDDLGSCTVKIFRPQIFINKYVNGNAGYGHIENFFLLNSDILNEPSFSVYYPMSLNYGGIGYTIGHEMLHAFDSDNYKIIFEGDNKNKFNVTQMSIKNFEEKSACFAKQYGLQKESITNKSINGLNTLGENIADNGGIKIAHRAYMKWLQSNGGKDKGVPGFEKFTNEQLFFISAGRSYCEYKSKVYLEKQIDKGRHSPAEIRTNVVLSNYKPFADAFECKLNSIMNPEDKCELWRKQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMC8</accession>
    <name>A0A0N5BMC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMC8"/>
    <dbReference type="STRING" id="174720.A0A0N5BMC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000706900.1">
        <property type="protein sequence ID" value="SPAL_0000706900.1"/>
        <property type="gene ID" value="SPAL_0000706900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF3">
        <property type="entry name" value="DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894614" evidence="1">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000706900.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="22789" checksum="E2E6C703B1D3A19D" modified="2015-12-09" version="1">MVSFIKLSSVFLFIAATTITITTGQMIKQCVCSEIQPCVSKFSDSVIVCADQCQHHVAKTGANYQALRSCILNKEPMIKSTIKCQNDKLANTCAKRPGNMVKKRYEETIKIAAISEINKMLSSSGVLSQVKPLLGVGKKFYSCVAKCMKGKAGNCQDNCGLDLPSDTVMVQQTKQCAQASGFSTPVVRDLCGCAVKAGLSQLNGVCDKITIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPE5</accession>
    <name>A0A0N5BPE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000777100.1">
        <property type="protein sequence ID" value="SPAL_0000777100.1"/>
        <property type="gene ID" value="SPAL_0000777100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000777100.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21475" checksum="2C35E1461EEC1A91" modified="2015-12-09" version="1">MNDEEFNNWGRAFKEIHNRSPKKDDYDIAPISIQEYFHKKDAERRALLKRKQPLECRMIVPNEDIINKPSIYSIVKRNRKTPRRSKKECGSKEVEKNVIEKDKIDGINITPQKSILESPLKGWRMPSNFKNNLLKTPTSEVKKRKVDGDFQAVTLSSPTKVILSKKSTGEIRKNLFHALKKLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQV6</accession>
    <name>A0A0N5BQV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000826500.1">
        <property type="protein sequence ID" value="SPAL_0000826500.1"/>
        <property type="gene ID" value="SPAL_0000826500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000826500.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23530" checksum="E30CB01B3DBAFDD6" modified="2015-12-09" version="1">MIINNPNDRIHPFLLIGFPKVLRSDNGPAFIAKSAAEHLKSMGIDHQLSAPYNHTSNAFAERFNNTLRAAIRVYKNKNNLSVIVAHFVYTYNRTKNLKTGLTPAQILLNSSDNGLHELIKDTKERFDNDIQRHGRKLNPGDLVLRKVMIRKDSETSQKNQLTWEVPFKIIKHLYGDTYEIERVGKRTRSAIEKVHVDRLKLYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSJ2</accession>
    <name>A0A0N5BSJ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BSJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000883400.1">
        <property type="protein sequence ID" value="SPAL_0000883400.1"/>
        <property type="gene ID" value="SPAL_0000883400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000004">
        <property type="entry name" value="40S ribosomal proteins S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000883400.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18072" checksum="2455AC7A19FFDA41" modified="2015-12-09" version="1">MAEQNERAYQKQSAIFENPKSLFTKAEGTVFKRRYTKDVGLGFKTPIEAITGKYIDKKCPFTGSVSIRGRILTGVVAKKKMQKTVILRRDYLHYIPKYRRYEKRHTNLAAHCSPAFRDLQVGDTVTVGQCRPLSKTVRFNVLKVHSRGRAKKAFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSM6</accession>
    <name>A0A0N5BSM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSM6"/>
    <dbReference type="STRING" id="174720.A0A0N5BSM6"/>
    <dbReference type="WBParaSite" id="SPAL_0000886800.1">
        <property type="protein sequence ID" value="SPAL_0000886800.1"/>
        <property type="gene ID" value="SPAL_0000886800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000886800.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55394" checksum="BB970402EEF30AEC" modified="2015-12-09" version="1">MDPKNNVKHGSSSYIMTTTPLPYGNSSINSPKNLPSLSTNVSSQNNSKIAYVTKATSVQRTATAPYNMVAKKNSYIRGGADEGPTVKEHLQKQSRLNKQKMQAEMNSSNQGNMSEQMVIYNYDNHSLIQQPHPNVVIQGGVRTQKMSITTTKATYIQQAHPSTYNITSQGRSPLKRPGAALSTGDNVNIPQTSSSSSVTTSSGSRMLSKIRKPPPQKIIQTFVSNNPGSYVEPLSSGQVYHHSNSINNYNQENVNSQHLRVPISAPIPTTTHNIITSKPVPPPKTTQRLTSAQLKQKQEDEKYQRKLRLLKKTIKSLVFKNTALCDEVSRLNYRIDTVSDERKVLAKKLQQHERNRIRRIQTVIKKEEAAMVNQSFISSFSNHGGMSSTSLSPTNTRPPSTASSSIGYHNIINNTIPSKNIPPSINISSNNKQILLHDDSGISNYHTDNCIIIDNQTRPSSANIYHHRHLNSSGGNSGPSDRGPIYFDDTALPIKIESQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT76</accession>
    <name>A0A0N5BT76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT76"/>
    <dbReference type="WBParaSite" id="SPAL_0000906450.1">
        <property type="protein sequence ID" value="SPAL_0000906450.1"/>
        <property type="gene ID" value="SPAL_0000906450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000906450.1"/>
        </source>
    </evidence>
    <sequence length="61" mass="7145" checksum="E17C7D5DAACFB7E7" modified="2015-12-09" version="1">MYNFSFFKDTINFNDPKNPMDYKTWVSNSNKKTTELIISTVYPFLSNNESTIQINNVNDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV34</accession>
    <name>A0A0N5BV34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Elongator complex protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV34"/>
    <dbReference type="WBParaSite" id="SPAL_0000970000.1">
        <property type="protein sequence ID" value="SPAL_0000970000.1"/>
        <property type="gene ID" value="SPAL_0000970000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000970000.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31426" checksum="A3A041F8E4850170" modified="2015-12-09" version="1">MNLKQLWSSGKDSDRLIVVEMPTSVRKDSHFRGLGDMFANEIYLNKNYHKLCLYDHLNDQNFFNLNVSDQVFVIFSFWEFVLTYKETNWKRLIQQLTQNNFVIIFSNPTVDENNVQLPTIDSKSFHHEIKKLRYITDQYWIAIGEAKGDIFHFKRIHYTSRKFFRKDYITVKNIDGKKSFLFSTEHPLGLDNKAKVDEKGMNPEKPKNDVRFDQNQGSYDEKSLPFLTQQNESGGMVEMGSNTVRAGGRIIFQEDEYMEDVDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV37</accession>
    <name>A0A0N5BV37_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV37"/>
    <dbReference type="STRING" id="174720.A0A0N5BV37"/>
    <dbReference type="WBParaSite" id="SPAL_0000970300.1">
        <property type="protein sequence ID" value="SPAL_0000970300.1"/>
        <property type="gene ID" value="SPAL_0000970300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000970300.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24260" checksum="635B8786F7C2D669" modified="2015-12-09" version="1">MAPKGNNVIPNAHFRKHWERRIKTWFNQPGRKLRRKQNRVAKAKAIAPRPAAGNLKPVVRCPTHKYNRKLRLGRGFTLAELKLAGLSAHQAQTIGIAVDYRRQNKSVEGLERNVERLKLYKSKLIIFPKNASNPKKGDATAEEIKLASQLTGTILPIVKEVKPVEILPVTEELKKFEVYRYLRRVRADKKYKGRREKKAAEAAEEGLGGSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVE5</accession>
    <name>A0A0N5BVE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3444 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000980670.1">
        <property type="protein sequence ID" value="SPAL_0000980670.1"/>
        <property type="gene ID" value="SPAL_0000980670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000980670.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9451" checksum="53597804BE0B40AE" modified="2015-12-09" version="1">MERNVEVPLPHVQEGHFVRTGPYVGQVPMNYGDFYNVVSNFSGGCQQNRKWKRIGRVESYHKDSKLLNSNNFYLTEDDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVK5</accession>
    <name>A0A0N5BVK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVK5"/>
    <dbReference type="STRING" id="174720.A0A0N5BVK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000986100.1">
        <property type="protein sequence ID" value="SPAL_0000986100.1"/>
        <property type="gene ID" value="SPAL_0000986100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000062">
        <property type="entry name" value="Hmg-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000986100.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10172" checksum="9595A57BCCE4CDE3" modified="2015-12-09" version="1">MAKVTKKTAKKPKDPNAPKRALSAFFFWLQENRERIKKPGMGVAEVAKAAGVEWNSLVDKKKWEKKAEDDKKRYERDLENYKKMQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW41</accession>
    <name>A0A0N5BW41_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW41"/>
    <dbReference type="STRING" id="174720.A0A0N5BW41"/>
    <dbReference type="WBParaSite" id="SPAL_0001004500.1">
        <property type="protein sequence ID" value="SPAL_0001004500.1"/>
        <property type="gene ID" value="SPAL_0001004500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327:SF7">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327">
        <property type="entry name" value="SPERM MEIOSIS PDZ DOMAIN CONTAINING PROTEINS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001004500.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33909" checksum="249234EF49AFB155" modified="2015-12-09" version="1">MTGKFDNVLLKKKEHLQYLSILKDNTKENIITLKINETVEPNVVFLNSDLIIEHIEENSCLFDYLVLGDKIIEDTGKKLPNENITLPAQRVNQWNIKIVRIGSYTPIPRQRFKNIGLEGREAGAAYFCINVQKPINDGNELGVTCYGSQNSFYILTTEPDTVGEATFLEGDRVLDIDGEKFGQSAQLNDLLEKGFQKNSFINCAIERAIGKTPLNRLRDLLMTWHSFKSTPLPDVVEVVDKEIKLVKKGRSIPKSTLKKDGSRCTTKSKLKIANDFKKFELQSLVPNNLLLERLIKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXF5</accession>
    <name>A0A0N5BXF5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXF5"/>
    <dbReference type="STRING" id="174720.A0A0N5BXF5"/>
    <dbReference type="WBParaSite" id="SPAL_0001048500.1">
        <property type="protein sequence ID" value="SPAL_0001048500.1"/>
        <property type="gene ID" value="SPAL_0001048500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001048500.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46002" checksum="324BBF501EE52F36" modified="2015-12-09" version="1">MNRSITLKYFNTNNTISKAFLSHQTSATPSTYKTTFKHEDLVINKCQKDQLKEKPKNMAEAKFGAIFSDHMVNCDWETNVGWKNPEIIPMRPFTIHPAAKVLHYASELFEGMKAYRGVDNKIRLFRPDMNMDRMLRTAKRCALPTFDPEEAIKIISEQIKIDESWVPYSDVASLYIRPTLIGTEGTLGVSDSNTAKFFVLTGPAGAYFATGFKPVTLLADPRYVRAFPGGVGQYKMGCNYAPTLLIGKEAAKRGCQQVLWLSGENEEVTEAGTMNFFVYWKNEKGEDELITSSLDKGIILPGVTRQSLIDLARELNTVKVSEKDFTMEELIRAIKEKRVYQAFGAGTAAVVSPVGKILYHNKKINSYEELNIPTMETNENIMEVLYKKIVDIQYGRVEHPGWTRIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXI4</accession>
    <name>A0A0N5BXI4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXI4"/>
    <dbReference type="STRING" id="174720.A0A0N5BXI4"/>
    <dbReference type="WBParaSite" id="SPAL_0001051200.1">
        <property type="protein sequence ID" value="SPAL_0001051200.1"/>
        <property type="gene ID" value="SPAL_0001051200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000043">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001051200.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21384" checksum="4D98F36ABE167DFD" modified="2015-12-09" version="1">MVTCVNNTEDYYLFSEDLLMGHIKDDIPEGFKLRPLHIKDYEKGYLELLEQLTTVGDVTEAEWIKRFNSMKAKDDGIPQSYYIVVLEDLTTQKIVGSVTLVIEFKFIHHAGSRGRIEDVVTDKNYRGRHISQILNRTMVSLAKDIGVYKLSLECKDTLIGFYEKFGFKKDQGNNFLVQKFDNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXJ5</accession>
    <name>A0A0N5BXJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SpoU_methylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXJ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BXJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001052100.1">
        <property type="protein sequence ID" value="SPAL_0001052100.1"/>
        <property type="gene ID" value="SPAL_0001052100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001052100.1"/>
        </source>
    </evidence>
    <sequence length="1145" mass="134358" checksum="FBB35C6383D2CA3A" modified="2015-12-09" version="1">MDIPLKKQRLIKDLSLGDAFYNGKFIEIIKNNNPNYVFEENVNFKQHILNGNFDKLPKNFECYFEDFVSSIDKDQRINDKWVVNFFLSCYKSKDTSKKMKSEALKSLKELTQYFSSSTPQLWNQYCKILEVLLEDQQHLLEHIVDEIYYFVDNWKDPLNAGENILFPLDFECILTLLIISVSKINGWFKYAVICIIFNKIKYVDIFKHLEFYTQIVHVVFGDHDVIWRCSNESEYRLFISGATNKFQGALIELEEEKQFDLIQEIIKTLIGFYNKPSPYAFYNFIQLFDINFKSEGVKKIEMKKFEELLKASRNLPAGSLRKHSYYIIFKFISQSMSVSEVTLVSYIALFSTYTGSYFTNQDLIDLFLIDYLQNNFDIDKLEDAYKNILFTVDKKLQYKFYSAIIFIYQKLGMEHKDLVVPEKFVIPKNEPFSLDICIQTMHYQTCNPGCDLILEYHKMLSLNPNYCSEFWLSLPITFEMLLNNAVKHKGSGDFIICIMGILNFLEDIKNDEIGKKYYYRNTSSDIKKYQRTISELFYKFYSKFKHVIFTNPRLAVIVCKKIKECPDLVLYIEDLKEFAIEEKPVEKKKFVDKFVLKDNIYSELLDLYLYPYATKNDFTSMRIVSEYSIKNLKNLNLMNCNQFNCFDYYYLTPLAARAEMLTFFNRLNEYQLSKLFKAIKEEMKTFNQSSTSFPFSDSHLRISRLLQLLMITINKFTLEEQENFLHDCYDIFHSKVHQSSVRIYGEIVASKIFFNNMNLLKMSVFIKYMREAYQIRPGSVVSFINILHNILKGNFSKMKENVNCNLIDEFLKAIAPWITNNNFAVKNSAVHTLKFIKNVINMYDKFKSDFSNSFLSIIIDGNLINNGNGTKILQNMDEDFYYGSYDIFKNDTLFTYLVVFPENLGFSVDESHKDLFQFWDEIFNNYLLIPYQNKDDLLLLNRYSILNGFSYPQYKIEINKLESSKISEETNDPSQRKIAVPKVLPKKENISVCIYVIASLVNKPENLGGLCRTCESLGIDKFLIDNLSAVKNKNFSALSMNADEWQDIEELKKDNIVEYINEQKKNGFKIVALEQTTNSVLISDYKFPPKVIIVLGDEKEGIPSKILKICDDVVEIKQYGKTRSLNVHVSGALLIHEYRIQHPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXM1</accession>
    <name>A0A0N5BXM1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXM1"/>
    <dbReference type="STRING" id="174720.A0A0N5BXM1"/>
    <dbReference type="WBParaSite" id="SPAL_0001054500.1">
        <property type="protein sequence ID" value="SPAL_0001054500.1"/>
        <property type="gene ID" value="SPAL_0001054500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000103">
        <property type="entry name" value="Hypothetical LOC496748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="211"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001054500.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50797" checksum="3DCFD9EFEBCCB719" modified="2015-12-09" version="1">MENIPNRTPYTVQYQKLYDDTVYPKISTSSRYRIKESNDEKLAKYAAYILTFFVVLAVIVCIPLLISIIATALENYKERVPMPLNESLLKMPMDNCNMSQEFFNEMDSEFAKFVTQFEKCYETMDEMKKRQEIFLHNNEKMKKNNEESPNKVKDTTFEWNYYTDWSEEEFADTMVMKIRDTNSVKKSKNSFVQNLPSDWRKERVDKAEGPLPEYFDWREKGVVTPVRCQKKCGLCYGFASVATMEANYAIVSGNLRNFSEQEILDCNLENNGCNGGEPYLVYKYVHDHGMVTAEDYPYVAHRQNRCALNPKSERAYVKLAYYLHPDEDSMLDWLYHYGPITVNIAVPKSMKEYSSGIYSPNDYECEYEVLGLHSLTVVGYGTDVDGEKYWIVKNSWNGRWGESGYVRFARGRNACGIEHEPIGIIMEKGMKHDQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXX2</accession>
    <name>A0A0N5BXX2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXX2"/>
    <dbReference type="STRING" id="174720.A0A0N5BXX2"/>
    <dbReference type="WBParaSite" id="SPAL_0001063500.1">
        <property type="protein sequence ID" value="SPAL_0001063500.1"/>
        <property type="gene ID" value="SPAL_0001063500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000043">
        <property type="entry name" value="Sterile alpha and TIR motif-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="720"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="866"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001063500.1"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125158" checksum="5016D9625295F7E5" modified="2015-12-09" version="1">MVKEPSTIETPTNFMSADSVERFQLSRQDASVSTSRKSPLGRTDNILYEVEDDESECIHVSSSTSSFNSSKSPIIQPTNEYIGKNNYKKINILTVGNHGVKDNNSENSMLSFRSHSSNCLEDSQSSNLSLNNNINHLSSEGLNGNNTVFNMNQNNQSSNKKIVKNYNSNCTPKWKLCTPVRSQLNMQNALLRQQTTLDDVSGKYSINGSQECPFDHLEQYSQSYFCGNNDKIYVKNKVIGPRNSNPGFETSYTNQNNTVSCKIGDVKLQSSLSTPCENVSSGNDNANKISNEYRRFKSEGSTTNPFSQTNVVNMEGNFNDIISLDHQRIHMSNNGSHPNYCRHKGHTQLTEATMPLNTHTDQVMLMHTLKTKLQKYQQFIDKAFELIQESDDSQVIEGCTIVTKVMQKAWLYPRISQDLAHALCDYLKEKDYLEIIINIFIKQNITEPVRLACGRLFEEILSLNNREYIVQNNYLKKITQMAEKLNKNPEQQRMSLSIMECLFKHSSSTTYRLIDYGILDHILLTCKRAADSPATLRQASLALANLVLYSCPEARKKIVQKKLPDWLFLLASQPDDITRYYACLAICILASCKEMELAVATSGTLVLVEPFLLSHNPTVFATNHYKQSQGRPKEWLIRLLPLLNSKCREAKSITAFHFTMESVIKKNQDKIAILHEIGAIPLLKEVASSPDDLPAQLASEALTIIGEEVPYKLSRQVPCWNVENVQCWVAKIGFEEYCEAFGKHKVDGDLLLLLNESELENDIGMKSGLLRKKFLRELESLKIAADYSSIDDSNLDTFLMSLSPELSAYTYPMLNAGITRTMLPQITEDWMVNVCGMTNEIHKYKLKQALQDGKHIDDIEVAQLSKQYDIFISYRRSNGNQLASLIKVMLTVQGYKVFIDVDRLHAGKFDSSLLKNIQAAKHFILVLTEHSLDRLINDHTCDDWIHKELKCAFEHNKNIVPVIADGFKWPADPNEIPADIRQIITFNGVNWVHEYQDACITKIKRFLTEYEENHKTIKNNSMSTLKRNISLASKKNTSISTPSMPSKLLGSGRKTNSGTGSGKNTPMHSGRLRNNNDSSIESPSYRGMSIEKASNRKFFSSTTAQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ32</accession>
    <name>A0A0N5BZ32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ32"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ32"/>
    <dbReference type="WBParaSite" id="SPAL_0001102800.1">
        <property type="protein sequence ID" value="SPAL_0001102800.1"/>
        <property type="gene ID" value="SPAL_0001102800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001102800.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24288" checksum="D661DF902017252F" modified="2015-12-09" version="1">MLDLTIFTNVSDFPYKKKFDENISLKDFKQKMIMIAGIEQLENMQVELIDEQKKPIMILDDESKTLSDYNLTDDSFVLVKDISGSNTEFLNNDIEDRYIMSNEKYASRENSVRNFKKQIMENTKETTYLKVGDRVVVMAKDEEKTGTVAYVGEVEFADGLWIGVNLDQPKGKNDGSVNGKRYFECSANHGSFVKPKSCELLDTETTANAPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZV5</accession>
    <name>A0A0N5BZV5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZV5"/>
    <dbReference type="WBParaSite" id="SPAL_0001129300.1">
        <property type="protein sequence ID" value="SPAL_0001129300.1"/>
        <property type="gene ID" value="SPAL_0001129300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001129300.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21811" checksum="7FC2A935ECC4A72C" modified="2015-12-09" version="1">MLKSNNMEVPPKEQNKKLKDKELFDTLMGQLKMYESVDQDIEQSLRALWSTGNYKAAEKLIDKMIGNIEKDSSKADRLATPEVKSAVNDNTLLRTLTPFEGNDVTEFKRWVETYDLAVSLAHQTLPNEQKEKLRCIYLASYLKGRAGQLCKDAYARMKDITFERLIGYIENNLPVPISIERTGRMRRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C044</accession>
    <name>A0A0N5C044_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C044"/>
    <dbReference type="WBParaSite" id="SPAL_0001137600.1">
        <property type="protein sequence ID" value="SPAL_0001137600.1"/>
        <property type="gene ID" value="SPAL_0001137600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001137600.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33339" checksum="8D36E953E9E815B2" modified="2015-12-09" version="1">MFCFCRFLFKGCFNGDESDEEYDGGDPNRRIHDTFGGVHFSDRFFWRNQNPFTLGGRIGPRVTHLRSNLYPTPDLLPPKYEDAIKIPTAEPPPVYSENGASELTLQPPPYENPITTFPQQLPTGTINCNTIRREFRIPQVSVTSSSQPFPSQFQIIYNNNTNRQLNINDERVRRNSTPETFDNTRGGAVMYLQYSGVENDDLPGSVNNDLERNKVSGEEDEVVSSGDSVERLSPNLVKQKSNSSDTINNGGTENVWKVRLPNSARYTRRSNSRTKNAEDNQPRQLNILTVCTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1C8</accession>
    <name>A0A0N5C1C8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1C8"/>
    <dbReference type="WBParaSite" id="SPAL_0001180400.1">
        <property type="protein sequence ID" value="SPAL_0001180400.1"/>
        <property type="gene ID" value="SPAL_0001180400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001180400.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9194" checksum="5A8CFD186614D4F5" modified="2015-12-09" version="1">MEKNKSINSEKIEKLASYLSKIQKADNEIINALHTLEVCLRIETKAINKARVGAIDIDYEKTRVGITKSRVKQVVDHLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1R3</accession>
    <name>A0A0N5C1R3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1R3"/>
    <dbReference type="STRING" id="174720.A0A0N5C1R3"/>
    <dbReference type="WBParaSite" id="SPAL_0001193400.2">
        <property type="protein sequence ID" value="SPAL_0001193400.2"/>
        <property type="gene ID" value="SPAL_0001193400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001193400.2"/>
        </source>
    </evidence>
    <sequence length="616" mass="71677" checksum="9A7A0C5300361FA3" modified="2015-12-09" version="1">MDHKQNWRFSIPQNSLLRKRMIQGGLINQQPKDRVINCQGSYYNNIKEESRVIENPIYQMSKISALLISNNTSKLNSDGDDHIRKAELNWTSKKKHFRDTEEWKIKKARIISKIKAMGKINLAFIISKMQTIETLPDKLLEHIFSYLNPYQKLTVGKVCKRWRKIAQGPALWVSISFRPSHGGLQILNVDHFTQLIGTRFTDTRSCELATDLITCNVLHEMANKCLKLEHLTLDFSTAMQLHDFTDLQFFPSRLKSLTLCLSENIFLEGFLRKVYTFVSCVENLHIVGTYEKVEDEEEEVYETVNMHKLKQYMPNLRVVNLWGVPFINDEHVDAISSNCAHLECLCVNYCNKVTGSCLKLVLQRCKKLRSLFLAHAKLDGAILQTIEWEKTQIEELDIRGTELKEDAIAFILCRLPQIRWLDASFLENFTDHVMDSWMNSGALKNLQYLNLDTCDSLNEAVLIDFVIRYGQQMLGLILGGHHKLLEYFWMNMIPNLRNINILVMGIAEDCCPKVNAKIHIDQFIDCVAQNCPKLTRFEIRWDDETLRFSDKSSKFIDVLRMKCLKLHSMVLSDGQYYELVRSNFERADRMSVVRTTEMCKTGLLHVSRYYNQLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C218</accession>
    <name>A0A0N5C218_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C218"/>
    <dbReference type="WBParaSite" id="SPAL_0001203250.1">
        <property type="protein sequence ID" value="SPAL_0001203250.1"/>
        <property type="gene ID" value="SPAL_0001203250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001203250.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9655" checksum="CA5B57E32DD21D81" modified="2015-12-09" version="1">MNGTIPHFIDSYVKIGSIVCNASQMVVFGFDEQKIAVVENFFIYKISTQKAFAVEVFFSFMECSSIQYPYSLCFKFEHLQVDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2S6</accession>
    <name>A0A0N5C2S6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2S6"/>
    <dbReference type="STRING" id="174720.A0A0N5C2S6"/>
    <dbReference type="WBParaSite" id="SPAL_0001228600.1">
        <property type="protein sequence ID" value="SPAL_0001228600.1"/>
        <property type="gene ID" value="SPAL_0001228600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="42"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001228600.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38325" checksum="39B068553B8E0D19" modified="2015-12-09" version="1">MISVISQLIVIIFIYYFFNNIYLKKINKFTNMVKELPNVSNFRIIRVVGSGTFSTVYEVKERNTGRSLAAKKILTSPDPKCKEFFHEVAALARLKSKYVVEIEYFSRRFKRLFIFTSLHKDNLSSVLKVYKKSKGFLPPNVIKVIMVQLISAVRYCHKKDIIHRDIKPENILIDKNFKLRLADFGCSLDIRRRPIVNIKFSTTYEYSAPELDLNVGLDSISQDIWSIGCVYAELLTNKQIFPNTNLPEPRFISIYKIVGLPYMEKEIIEKLMPYNIDLNTSFPTTLGKLCGYKENSKEIKLLKFFLNPNYSSRMNLRDALIYDVLASKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2T8</accession>
    <name>A0A0N5C2T8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2T8"/>
    <dbReference type="STRING" id="174720.A0A0N5C2T8"/>
    <dbReference type="ESTHER" id="strea-a0a0n5c2t8">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001229500.1">
        <property type="protein sequence ID" value="SPAL_0001229500.1"/>
        <property type="gene ID" value="SPAL_0001229500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895480" evidence="5">
        <location>
            <begin position="19"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="19"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229500.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66448" checksum="A85FEADC753FC49F" modified="2015-12-09" version="1">MILIFLKISIFFVLLCDAQSIINTLNGPVQGINKHFEEGIVTEYLGLPFAKFPYKYQRFMPPSDLGKPEWSETFFAKNPAVSCYQYSEHFNFSGIDYLNSTNKLREDYLELNMWVPQNKSGAVLVVIFAGGFTSGSPSSDSNNGSVLALKSRAIVININYRLGIFGFAYLGENSKIKGNMGFLDQQMGMKWVYENIGNFGGNKDMITIFGQCSGGASVTAHFLSETSKNYFKRAVVFSATIANFWVTVSPKTVQENTETVAKLLKCSGNDEEKMKCLQTVDASKLLKASVTLHNRKLKTSNDAFLPINSDTVFFKGSVDDKLKKKQMKNDFDLLFGRDSDEGTYFMVKYLKKFGCNFDPKKHPECEDNSCRLNDTTFRDAVQILSNMVEFNQNETAELFMIYNSIKATKPREKVAQLFSDVIINCECSLFLDSYLDTTNKNIYLFEFRRRSTVNPSPKWMGINHGSELYYFFGHPFRYPYKYDRKDLQFEKKFSEKLMEDLGEFAATGKPKTNWKKFTKASKKAFIIDDFYCKKNHKKYVLATSKRCVKFNQLMEQRELSYKRNFFLNEENEQIDNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2X9</accession>
    <name>A0A0N5C2X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuropeptide-like protein 31</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2X9"/>
    <dbReference type="WBParaSite" id="SPAL_0001233600.1">
        <property type="protein sequence ID" value="SPAL_0001233600.1"/>
        <property type="gene ID" value="SPAL_0001233600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895253" evidence="2">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001233600.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8101" checksum="FF7B7FB055D16FA1" modified="2015-12-09" version="1">MKNIFVILLSLTIFVSLCNAQFYGMYGPGMGYGMGYGGMGYGGMGYGGYGYRPWRHFGHYGYPGMGYGMGMFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3S0</accession>
    <name>A0A0N5C3S0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3S0"/>
    <dbReference type="STRING" id="174720.A0A0N5C3S0"/>
    <dbReference type="WBParaSite" id="SPAL_0001261000.1">
        <property type="protein sequence ID" value="SPAL_0001261000.1"/>
        <property type="gene ID" value="SPAL_0001261000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000007">
        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF22">
        <property type="entry name" value="PEROXIDASE SKPO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001261000.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="72751" checksum="E5C1A5F0D15D31A3" modified="2015-12-09" version="1">MIRKLFLLVDSDCRQNGCCDNNKHCVTWSLLGECTKSPKFMLANCKKSCNACGSNGSINSFPRFSNDNLSGCPLIQTSQLSTDFELSEPIFRSFLKQRQCGVETSIKDCSKSICYHKFFRTPDGSCNNIENPTWGAAKTRYLRLLPSFYEDGISIPIGMKTIFRPHPRTVTRHLLNSDKNIFSNFNQLAMQWGQFISHDILFNGRSDFCTCQTFSNTNCMNVNTAKDDISKLMRKVMCTPITRSIPVCRNDDLTSPREQMNLNTGFLDGSTIYGSTTETMNNLRNGHLLKFEKSASGSEFAPEALSMLGSSMKLGDERGLIFVGIASLHTIFLRYHNIIARELKTINSHWSDDRIFQETRKIVGGAIQSITYNEFLPALLGSDNLDFLISKYIAYDDSVSPAISNEFSAAAFRLHGMVVKNYPFINDNYKVLGNIKFVQGTNTFLPILQRSISQLMRGLIATPLRKPQRLTSQVTEELFDGIFDMATINIQRGRDHGLRAYNDYRIYCGLKPIKNFPDWEDVSDADVKLRAQQLYRTPDNMELYVGGLLEEPIKGGVVGPTFACIIADQFKRLRDGDRFFYQNNEVFTNLQSKEINSISIASVICSSEPDIKNVPVNAFDADKGENAVPCSMIPFLNLSLWRSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4R2</accession>
    <name>A0A0N5C4R2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4R2"/>
    <dbReference type="WBParaSite" id="SPAL_0001294300.1">
        <property type="protein sequence ID" value="SPAL_0001294300.1"/>
        <property type="gene ID" value="SPAL_0001294300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001294300.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29623" checksum="263CD2915E28463E" modified="2015-12-09" version="1">MAQPTMAQRQSYDFCLSVTLFNHRDQTQRVEQFLESLNEAFELDGITQDRVKINVLRQRVEQVTRRLLPTVAATETFQSYSTKIRNAFPSSYSDTLASDKYYKFKFDMKSFEESLLQFEHLAEIVLANYPEADKLNSIKDRLKCQLASYKDLYEYVRDFDGNPVTLFRDLIHRYEDEKIRRQTANAGKFSRYTSFSRFKSIKCYHCQILGHTSDQCKRKKQGAPPGDYSRRPIKTEFEGDATGRPISNEVHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5J6</accession>
    <name>A0A0N5C5J6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5J6"/>
    <dbReference type="STRING" id="174720.A0A0N5C5J6"/>
    <dbReference type="WBParaSite" id="SPAL_0001322400.1">
        <property type="protein sequence ID" value="SPAL_0001322400.1"/>
        <property type="gene ID" value="SPAL_0001322400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001322400.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="91055" checksum="A928FE1A8B580F3F" modified="2015-12-09" version="1">MKKYRNRNLDQSTALKFKTVCDVYNSFNPAIPAEDILILGQLTYPRFTTDHTKLVRHCQEVLDLVYTLKFTKSDSPVSDKSNDMHASSRMERFNPMSGKSIEPWIKQLERCMKLDKIVEEEDKINLTLACLPLEITETIDELPTSDFDTYSKLREILLNKYNGQISRQTAFARLRSFKLDINVDKFVSSCQELGEIVKQISPGISKDALLNIQISQLTTHLQPYRSLWTFITSRNNFGSYEELVAELDTNNRLFKASIGKGRGKEGLPPKKSAAPKDKSTITCRKCSQKGHYANECTNKSVGKPVQTNNKSPNEVRAVTSNNSDVAAQLDETNRMMKHLLEMQNYSINKITLDDEGKRMEANVEELTDEETDTIPPPTSNDLGKSAVVNPVSDKTVFDVKSKNPSFPKKSKMQKVQLKESKKNQSPDAIVRNANSNLLFIVPVEMSDGRVYPTLIDSGADVTVIKHSIARRTGANSNLLFIVPVEMSDGRVYPTLIDSGADVTVIKHSIARRTGFVASSADTMKLKLANGENWRTIGKHHTKLRFLNNVYVWVNAIVVEDKDLQNPRYSMIIGSEVIHASEMIIDYKNLSLFVCDRPLKHLSVTKNETKINNVVASMSIVDDFQLKEIEDLKNEFYDVISFDKNRIGLSKLMAPTLKVVDSNLPKLPRYFLPSHQIPIVEEQISQWLNSGTIKEDFYVKYLQNLVCTRKKDGTWRVCLNCKPLNSKLQDYYYPSPTLKQIIPILSNGDWYTCLDLCQFFTQIGLDDESSQYLGFVAPNGKTYKFTRLIYKFCHLEQQNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5P8</accession>
    <name>A0A0N5C5P8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5P8"/>
    <dbReference type="WBParaSite" id="SPAL_0001327500.1">
        <property type="protein sequence ID" value="SPAL_0001327500.1"/>
        <property type="gene ID" value="SPAL_0001327500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF70">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895401" evidence="2">
        <location>
            <begin position="19"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="244"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001327500.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="79832" checksum="218E7327D9E72B95" modified="2015-12-09" version="1">MRVILFLLSLYYLPFTNGKVESFDEEYVWNFLRNVPRDSVSKKCGESLDRVESYLTDYNTLPNEREFYYNSFGIGLTSQHNSRDMDRWIHKAYECTKAAGETAYSASQYPLNFCYSQNTNNPSSDTYAICIPSTCNKDTKYILNEFQNAAGKAEFKNESTDYHTCIQSRYDKQWYEQFIPVADFALDLMLILLVGVATVYHVKKGANGKSMSSKLLLCFSAKRNIRRLVQMPKDPQSTVTCMFGIRFLSMVWTVIGHSFIFVQVYIDNVEDFKSDLVNNFWNQWITNFTLSVDVFFTLSATLTAYSWFKKWKKNTSVDEPTWTSYGYWLRFYRHRVVRLWPAYLYTLFTVTTRISVTHYHGMWPPTDPAVQCPIHWWKNMFFVNSLFDNRCLPWTWYIGTEFIFYLLCPIFLITLRQMPKVGIFISVATMLASCFGNMGGMVYYNFPPTQFLWNQPAMFNDDYIAHHLIMYNKPWYRISPYIAGLLLGYYLALIQHSKKVLHIKYQVLGWVMGCSLGFWSLYGLYPSLQGWDWPIYHVFYGGFHRLAFSLFICWLIYACHTGIGGIINKALSLPILLPLSSLCYSVYLFHMIPVVFTYMLVSFPIVFTTKWFVLRHCFYQLCIAYFFGMICTMVAELPVLNIERVLLTRERKRTLKPISTNDKDCEMQLKPNPITVESVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5T9</accession>
    <name>A0A0N5C5T9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5T9"/>
    <dbReference type="WBParaSite" id="SPAL_0001331600.1">
        <property type="protein sequence ID" value="SPAL_0001331600.1"/>
        <property type="gene ID" value="SPAL_0001331600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001331600.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="9008" checksum="B903E1502559F4AA" modified="2015-12-09" version="1">MYREIKTQLFVYLTTIPLKLSIMDKLAAGYYNAEETVNYWDGIPIKNIFGRTKQQLNFVKSWSWSVYQRKTFDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C624</accession>
    <name>A0A0N5C624_STREA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C624"/>
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        <property type="protein sequence ID" value="SPAL_0001339900.1"/>
        <property type="gene ID" value="SPAL_0001339900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001339900.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9415" checksum="5467F5F2A6846DE3" modified="2015-12-09" version="1">MIESIEGNVKTENSGNVEVIEMGESEKNDFGYHDNVESFELYEVEKKDFNNYDAETNDLDEVEENDYKDDSSSKFCVEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6C0</accession>
    <name>A0A0N5C6C0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI transamidase component PIG-T</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6C0"/>
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        <property type="protein sequence ID" value="SPAL_0001349100.1"/>
        <property type="gene ID" value="SPAL_0001349100"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001349100.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60965" checksum="6A8E33A84AD7773B" modified="2015-12-09" version="1">MSFVRTEILHDHTPSDDFKEALFITKLKNQRTFAQFDFTIKAGNISSQTYDLFPRTIAEIVEKHSLDYLSFSLAFSNWLSNDWGYQPQPENPVGASLKVSFQNESYHDDAWTNLINSLSGIFCGSWHNSATYYTITIDKLYKEAVFPEESVCTENFSPFLKLLPCKGVAGIASLMNTELFYAAAFNSINLNFNRTMGNLKIMINFVGSKDKGIRNFDFESLFGKSLSSYSCELASSSKIYIEMFDGLKLSVTPDNVLEKFGRNFAVYNLLRANFSSISGLYENPTIKPRERLSYPPLVTIHSSTSHVGEQSGSIITKIRNNHSDKINVILSQSIQWYIKVFLHTLTFQCDGNDVPFKFQRVIQSKIRDRPYYFELSTKLPSGSLCILKFNYGLHFLKTSEYPPDAEKGRVIEGIKLDLLLPSDVYFSNATYINMEEIDNDSEYINFSIYGHPISIQLPLPDFSMPFNVICMVCTVMFNFYGSFHALSTKVMLKPTGSSSEQPVLRRLIIRLFDRIRNLFGRKPPTIETEKLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7G6</accession>
    <name>A0A0N5C7G6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Uridine kinase</fullName>
            <ecNumber evidence="17">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">May contribute to UTP accumulation needed for blast transformation and proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RNF19B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7G6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7G6"/>
    <dbReference type="WBParaSite" id="SPAL_0001387900.1">
        <property type="protein sequence ID" value="SPAL_0001387900.1"/>
        <property type="gene ID" value="SPAL_0001387900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000200">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="19">
        <location>
            <begin position="167"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="20">
        <location>
            <begin position="403"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001387900.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73050" checksum="D8C16DB359316E64" modified="2015-12-09" version="1">MSFHETGENHDYDLVTSKKKDSKIEEEIHIKNNITKSPSNNMQLNKGNSDVDLSSPDDSLNIDDEDIYKEIGEFNEDIVKKVNIDDICLKVICKSSGDSINTISEKSGSTDIEHVVSGKSLTKRSRTISGSRTEDHFLSTESGKRVYTKGRPPWYDKTGKMLKQPYLIGICGGSASGKTTVAKAIIQRLEMPWVTVLSMDSFYKVLNEEQHILAANNEYNFDHPDAFDFDLLLDVIKRLRQGKSVDVPVYDFTTHSRDKNSKIMYGADVLIFEGILAFHKAELCKLMDMKVFVDTDSDTRLARRLHRDVNERGRDVEGILEQYLKHVKPAFETFIAPGMKMADIIIPRGGENKVAIDLIVRQVKGQLAERGYDPTKCIINNRSLLTNHSMPEELPESLILLKQTRQIIGQITKIRNRECTRDEFIFYSDRILSLLIEESMNHIPYVDHLVTMANGKVVRGRKKNTELCGISIMRAGETLEKALRNVIKDCKMGKMLIQTNEVSKEPELYYLRFPKNVNKYKILLLDATVASGAAAMMAIRILLDHDINEEDIILCSLLMAEPGVHALAYAFPKVKLVTAAIDKEINENFHVLPGLGNFGDRYYGTENKGTILEEEVSSESSSDVSPATSEENLSTEYHEANHITASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8A5</accession>
    <name>A0A0N5C8A5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8A5"/>
    <dbReference type="STRING" id="174720.A0A0N5C8A5"/>
    <dbReference type="WBParaSite" id="SPAL_0001415600.1">
        <property type="protein sequence ID" value="SPAL_0001415600.1"/>
        <property type="gene ID" value="SPAL_0001415600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001415600.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20136" checksum="05C0FD9CC12BAF3A" modified="2015-12-09" version="1">MSGKDFKQEMPPPGGYRTFNSSRTYAKQLFRPGLVTGIIAGCTLYGIYQSHMIRKHSITEKFEDVDIQNAMQPFLTAERDREWLRVLKKNRDLENEIMKDVPGWKTGTWYGEPVYFTLGDKWWDPSIIEAYAHSDPSDMNTETFWSHHAEYTAPKFYDKYLPKWLLDYMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8F6</accession>
    <name>A0A0N5C8F6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8F6"/>
    <dbReference type="STRING" id="174720.A0A0N5C8F6"/>
    <dbReference type="WBParaSite" id="SPAL_0001420400.1">
        <property type="protein sequence ID" value="SPAL_0001420400.1"/>
        <property type="gene ID" value="SPAL_0001420400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001420400.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41099" checksum="230356D7D047EABB" modified="2015-12-09" version="1">MKSLCCVKCCFGDSLSTYNCGKEDENNSTKEQTFSWDKRNENSDSYISKDLKNKYCVRRSGEINGQQYVVENCSNCTIIVKDITGSVNIDDSQDCLIILGPCNGSVFIRDCKRCQIFTICQQLRTRDCNDLSLFVFCQTQPIIEESTRIRFSPLFLNYEGLEDQLLSTSLSPFINKWNKVHDFTPLPQGSNYVTRETTDYSGFGDKLYHIKEQECIYTENNESLLPYTRTILSKEPTKKFLLVLTQEKEETIRQFYKRGLSIMKFIKMNVPQSVITDSFDIKIYKKELKLIATKNSEYLKNFSGQLLFIQILNIKKEEIEKSFENIIILDEDINEEKEHINFLYRLVNIKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8I0</accession>
    <name>A0A0N5C8I0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8I0"/>
    <dbReference type="STRING" id="174720.A0A0N5C8I0"/>
    <dbReference type="WBParaSite" id="SPAL_0001422700.1">
        <property type="protein sequence ID" value="SPAL_0001422700.1"/>
        <property type="gene ID" value="SPAL_0001422700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001422700.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41468" checksum="9832A65EE6621EDA" modified="2015-12-09" version="1">MKEENNLVVSVIIPVKNGEDYLDDTLKALLNQRCEGNVQLEISIYDDASVDRTDEIIKKWKDIFLKENYLFIHSKAKTNKLGGVAYAKHQAIIQSTGEYLCFNDSDDISSVDRIDKQLKFILMNETPFNILLGSNFIRIPHDSTVRFTRWANNLTEKQLMVQCYTSNGPTVIAPTWFMSKKLYDAVGGFKTDIVSGFPEDLDFFYRALRKGVIVKKVPYNLVTYRYHSNCATFNVNEKTIWEMRVREVSEIVLSKWTSFSIWSAGKQGKLFFRSLREEEKNKVQAFCDCDEKKIGRQFLEIYDEKLRLVTHRIPIVPISKIKAPVLICVKLDLTNGCLENYINKKNWIEGRDFFHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8L3</accession>
    <name>A0A0N5C8L3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exostosin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8L3"/>
    <dbReference type="STRING" id="174720.A0A0N5C8L3"/>
    <dbReference type="WBParaSite" id="SPAL_0001425600.1">
        <property type="protein sequence ID" value="SPAL_0001425600.1"/>
        <property type="gene ID" value="SPAL_0001425600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF129">
        <property type="entry name" value="EXOSTOSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="3">
        <location>
            <begin position="69"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001425600.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="48762" checksum="2937C8C3136E7380" modified="2015-12-09" version="1">MLRCSRVKFIFSILFILCSIYLLIFYYTFFSNFEDDDFNINIYYQPRKLYTKFESCTFETCFDLSKCKSKNLKLYVYPNNEQSQEPSLIYSKFLSILRKLPYTTTNASEACLFILSIDTIDRDRISENYVKDIDAQILNLPKDIWNDGRNHLIFNFYHGTYPDYSDHNLGFNYSKAMIARSSFSASKLRYNFDMSFPLFHPDHTFTKYEAMNEKLKMKRIEAEDKYFVSFKGKRYVYGIGSETRDSLHHLHNGHNIIMATTCKHNNDWKKFEDSRCEKDNEMYDQYDYNDLLRNSTFCLTPRGRRLASFRFLEALKAGCIPVILSDDWVLPFSEIINWDNGVVYTPENMTFLLINQLGKLTYSKVEEMKNFGQQVYWKYLSNYESIIETSINIVFERVRALQKKLLNKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Y3</accession>
    <name>A0A0N5C8Y3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="SPAL_0001436600.1">
        <property type="protein sequence ID" value="SPAL_0001436600.1"/>
        <property type="gene ID" value="SPAL_0001436600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001436600.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24498" checksum="54BEE0300FB91A8B" modified="2015-12-09" version="1">MLYSKSFATTQIERDCIDLDHNCADWVAQEPSQCSTTDYIARSCKKSCSVCIKFSKRFDIRRLPESLRLLSWLVGIWRSEHDGKVTFPTIPKFTYGEQIEISIPDDELTATKALNYSANAWSINDQEELHTESGFITVKPGTNHVALNTVMSNGFVTIEEGEATYNHLKLRLIDIGRISFSRDLPVHDVVREWTLLDSTTXXXXXXXARTYIYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C985</accession>
    <name>A0A0N5C985_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C985"/>
    <dbReference type="WBParaSite" id="SPAL_0001446800.1">
        <property type="protein sequence ID" value="SPAL_0001446800.1"/>
        <property type="gene ID" value="SPAL_0001446800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895617" evidence="2">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001446800.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12435" checksum="23B45798F0C56B91" modified="2015-12-09" version="1">MKSFTFAVVLILFTTLLTSESFEIKRDLTYNNKENALNSPIILNDEDFNDIEKRKTKKQTKKPKKTKKSICQRITSLEKNLAKLKEQLKVYLGDVYSRFRTPSPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAF9</accession>
    <name>A0A0N5CAF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAF9"/>
    <dbReference type="WBParaSite" id="SPAL_0001488200.1">
        <property type="protein sequence ID" value="SPAL_0001488200.1"/>
        <property type="gene ID" value="SPAL_0001488200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001488200.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8120" checksum="E71D04262B44DCB5" modified="2015-12-09" version="1">MYSNHKFHIKLTSTIVVNRISNDDFGTLYELQFSDNTYTFWATEKDIQKISKQLEKLMSDTEVKRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAQ2</accession>
    <name>A0A0N5CAQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001497200.1">
        <property type="protein sequence ID" value="SPAL_0001497200.1"/>
        <property type="gene ID" value="SPAL_0001497200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497200.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13517" checksum="25EC2A5B11F30159" modified="2015-12-09" version="1">MDSLLKKSCYKVNGRRCTQKAHKNTGVCLQFLLFWCFIPAVSLDLYAVVVAQYLLCHWFCCSDGPLYIFWVLKYVMTEKFVLDCSSFAMILKHSVIRKLRSKYTFGLPHFYGFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB86</accession>
    <name>A0A0N5CB86_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic aconitate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Citrate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB86"/>
    <dbReference type="STRING" id="174720.A0A0N5CB86"/>
    <dbReference type="WBParaSite" id="SPAL_0001514900.1">
        <property type="protein sequence ID" value="SPAL_0001514900.1"/>
        <property type="gene ID" value="SPAL_0001514900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072350">
        <property type="term" value="P:tricarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="13">
        <location>
            <begin position="64"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="14">
        <location>
            <begin position="691"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001514900.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="97645" checksum="9A31F1B8EBAF0799" modified="2015-12-09" version="1">MAYKHLVKQLTVEGKNYNYFDLNDLKDERYDRLPISIRYLLESAVRYCDGFHILEKDVQNILDWEKTQFNQTEISFKPARVLLQDFTGVPAVVDLAAMRDAVQAMGGDPRKINPICPVDLVIDHSVQVDHYGDLTALAKNQDIEFERNKERFNFLKWGSKAFKNLSIVPPGSGIVHQVNLEHIARVVFCDNENNLYVDSNIGTDSHTTQNSGLGILAWGVGGIEAESVKLGQAISMILPEVIGYKLTGKLPQGTTATDLVLTITQNLRALGVVGKFVEFFGDGVANLSIADRATISNMCPEYGATIGLFPVDNRTIKYLIDTGRDLHSVKRAEEYLKTNKFFVDYNDKTFNPKYTKVLELDLSTVVPCVSGPKRPHDRVELSKLHSDFKDGLTAKVSFKGYGLTQEDSLKSVKVTINGEECQLKHGSVVISAITSCTNTSNPSVMIGAGLVARKARSLGLKVPPYVKTSLSPGSGVVTKYLEQSGLLPDLQALGYHIAGYGCMTCIGNSGPLGDELTKAIEENDLVVAGVLSGNRNFEGRVHANVRANYLASPMLVVAYGLAGRVDINLETEPLGYGTNGPVYFKDIWPTHDEINEFEQKYIIPQFFKEVYENIEKGGDNWQKLQCPDAQLYPWDLSSTYIKRVPFFDGMTQVPGKRDPINNAYALLSLGDSVTTDHISPAGSIARTSPAAKYLNERGVQPRDFNTYGARRGNDEVMVRGTFANIRLVNKLAPKTGPLTTHIKSGEVMSVFDAAERYRKDGDTVIILAGKDYGCGSSRDWAAKGPLLLGVRAVIAESFERIHRSNLVGMGILPLQYKDGASTESLGLSGQEQFTIDVESLSPGQDVDVKTSTGKSFVVKCRIDTEVELTYYKNGGILNYMVRKLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBM9</accession>
    <name>A0A0N5CBM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBM9"/>
    <dbReference type="WBParaSite" id="SPAL_0001529600.1">
        <property type="protein sequence ID" value="SPAL_0001529600.1"/>
        <property type="gene ID" value="SPAL_0001529600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529600.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38492" checksum="E36B01AA8847CBF1" modified="2015-12-09" version="1">MDANTWRFNLASIFKQFTIGINGLNCSYNGAAYRTTLKELKNLLNKNPDSIQIKNEPVKRFQAIGKAVKFNASFNEVTISYDDASVKARIMKVPIKNQSRELGGLNDCEGVLVFLTYGMSKGLVDNFTLEGIFKISNISSYEKIFQMEMDVMNLANNLNIFNLRGDRFLEIASGFIDSEEYEEEEENTAENDTFTQRSSITTPRRSVISERSIVTSSQQQTTPRMTTNPLKRRNTNDVPPTPFKIPSKIPCKEESHYSARNPYDDDSQNEFRIEVKDSDIIDVIEMEFESSNKPKIPVESIRCFLGIGRVDFSRAMGRLRDRYQLVDNLTMIKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBV6</accession>
    <name>A0A0N5CBV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUC173 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CBV6"/>
    <dbReference type="WBParaSite" id="SPAL_0001537000.1">
        <property type="protein sequence ID" value="SPAL_0001537000.1"/>
        <property type="gene ID" value="SPAL_0001537000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1541"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001537000.1"/>
        </source>
    </evidence>
    <sequence length="1557" mass="175952" checksum="E44F18539FBABE2F" modified="2015-12-09" version="1">MTVDVDIIKRNNTRKTSIGCDNFSDLIFKFMHLTLIKQYIMQFDMPPKKDSGSWAPYGLAGLKPSLPDEEIIEKFRRSSKYFSRIIESKEKNLSKIDDSEETATTSKSHRKEQAGLKAIKEIEELRKDKSKYASWMETLISDGYIKKGNDEINALIVSNVIKIAAIACPDIPFRNKETAAEIFEVVLEVFPKVVNVEDRLFDDYCEILNIFYLYDIESIITDWIGTNCLDLTERLLTSIIKCAEMAIPSSPSGVLIKKIGELGSLLVKILVQILSNMYISVQTLDVVFYYLVQPQKTNFKKSFELCSKALSKADAYPAVVGASRIIRESLVNNSLLSGKRSGDKLFSIIHSLEVIVPGFINDLVGDIQKLATTGGNDKARHCLWICALESSSKVLSKISNPEQVFKYRPEWTDSQKVQNIAIITKIIENSNERLPYIDSYISNLFKDTHVNSKLQMLNSVYVISTKDFSKISEKVLKSIGTLVLDSEETVRHKAMTLLGSIHLKLYTDNARDAYKEKVINAMSYFFNFIKHSNSSDIQKLERILVSSILSSKMNEEQKLDIMEKLFICFNSIGIFTFCILLQNRSSLFGIVRDILFMYNDVRALKDEHIMNEFLNVYSSPNALSLYKDLPKILSSLRDHGKFKDLYDIYTSRELSIKNVEENLAGLLEKLLQSSIDKKNFDEFRKLIERSAPLFMDSSFAQHILFTLSKLSKEGKKANILRVFYLTTIVRKFLNGFEFNFLSSIRLMVDIISNFDIEPISDCVMYILRNIFASNIRFDLSSEEREMLTNVIMKSFEKGTPKVVKYGVSILFHMTPPHKLQQVVDDLINKYSNNLETKSSQCSRSLTILSEILRCKEAFKTGKSVELNFPEGFWEALVEKAINIVENSPRNLTDDYKVISNADLREVMMDPNSKALSDFEKKYSFAASHDGVRLPLTRVQFAAFPLYFDKSTYNITSAINLIYNALTYHLQKETSLIEKVATLFKDILLEKVSYWFDFSQDQESTVKYYISKKLLFLKLNSNLDVFLNFTNLVAVSKCLHDTDYDVRSKIVDKIVGNVKHGGVPLMSLLPLVLYSSGHNVAAKAEERFRKYTMGAFCSLIQSQQELSHKYKSMTDYHCFFLSEYSIVYTIICIALTPGYDNFRDMDIIKRAIPVFEAILMSYNNLSKVINISLVKNILSTMKESKLSLISEGRTTESPLIDVDYRVWVLAELCLSLGELVFGIFGTTTQTAPDVVFPNTVLVKTRRSNNQTLSMNAVINELCQGTKKPKSMADIVSKSLIKLKKSNVTKKEKAKGHAPSNSGNENNASKDVPQIVIPINDDVVSSALETKSKSKATRSKKNVPIVVVSDTDESTTNTDASKVQTTNKRGSRRKAGAGKVQKTVEKDNRSSRTGSTANDQEISNDDVAPTRVTRSRTKRSSIASVVSEVPASKVTDKEQKGSNDLPNAVTPRITRNAANRKTPKGRQSRKSTAVERAEDDESFSIENVSAIPLEDGERDPNASLFDMAEREDKKANTRKRRALSRNHHNVGSAKRAKDGTKNPLASSTPYHPNSNILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBX6</accession>
    <name>A0A0N5CBX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBX6"/>
    <dbReference type="WBParaSite" id="SPAL_0001538700.1">
        <property type="protein sequence ID" value="SPAL_0001538700.1"/>
        <property type="gene ID" value="SPAL_0001538700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7381" evidence="3">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="203"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001538700.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37539" checksum="FEA2CA2A6A782BAD" modified="2015-12-09" version="1">MLLSQYTTTFFLLILIDLTSQLYLIPYWIVLYEGNSLFEYNDRQYKTMSDMISVILLDRKIKKPEDAYLYNVGFKKGTIVTKTDVKTCECITSFLYPGIKSATCDVRHRNPSRNIYKCNKQSFNNFDDALEQSLRHNCHIKFYPPHCKPSIPPKNICITTLFGVKCLMRNPATQSIWKRVWSTCNGNCFFNSGFAHTRNHYLKELNQYRGLVGSPPLTMNPKLNVMAKSCAEKLAYRNKLISEKKGDYDEFIAFAKEGYGLYLIRILFDDYYFSKSNFGPGSIKYKNDFTRLLRQKQRIVGFGMSRNGYGTYICIRSTSDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCC2</accession>
    <name>A0A0N5CCC2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCC2"/>
    <dbReference type="STRING" id="174720.A0A0N5CCC2"/>
    <dbReference type="WBParaSite" id="SPAL_0001553200.1">
        <property type="protein sequence ID" value="SPAL_0001553200.1"/>
        <property type="gene ID" value="SPAL_0001553200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001553200.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18713" checksum="BB47BF908BF66245" modified="2015-12-09" version="1">MSAAATQRLICKRQTLDEAYAPPANFLEVEVVNPITHGVGKNRYTDYEVRLRTNLPVFKQKESSVRRRYSDFEWLRNELERDSKILVPQLPGKSIKRLLPFRNDDGIFEESFIERRRAALEQFLNKVTGHPLAQNERSLHIFLQNAEIDKNYSPGRIRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCQ6</accession>
    <name>A0A0N5CCQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001565600.1">
        <property type="protein sequence ID" value="SPAL_0001565600.1"/>
        <property type="gene ID" value="SPAL_0001565600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001565600.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="74619" checksum="28CDFD5E5CC608BC" modified="2015-12-09" version="1">MFFTNEMKRKPLDEIFNGPAKKNNIFTFKNKVNKIVEEKNLYIEDQRRASLMIPPYNTDSRGVQGKFGSLIREINEDDYSLGTEDKLSLIDHIFKESIITEWPKEIIEGDRKIEIDCAPLIHKARTVKKCRTQHPTLRVKICGAIKDDTNASTTIKYLKVKLTLRKFKPDERDDSSSPAGHLMLTLREGTSTYRAPPSPLKINEVGGVLECEMKNQNAPDFNHQQFLNSIGISTSNGTENNFIYENDILTVTFPEIGMKIFSMTDRRALTTRYVLEVDVEMNFVDGHTIKHKVDTKNFLIAITNDQTEALLNSIFWSRLGTPESCTTSRLTEKEDIDPPYIKYGILKIALQNFMKAQVSNARELDKHELLHIQCMLFLPRFVNLTKEEMVEKLKELYTNDFIDNIDMETFNIESVREILLTDFVLDSVSVDKNEFMTNPLVSLTDCSTILEHRLWNWFYRTYEMIADIGHKLCTSTQVIEKKVSKNRRISFNSQSSTSIEDPITMVSLFNQRLITFTSRQHAYELLKNRTIDPGRGAMMLRFCEDNQGFISFIFDHKDGKPRIGSISCDKIKDNKKGLLGVLMGDDYPKSFEYMLKIEVDNHLSAIKEAKNTLFCQYQSNMNDCNKKIINDQLFTSVNPSSGEEVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD15</accession>
    <name>A0A0N5CD15_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase delta small subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD15"/>
    <dbReference type="STRING" id="174720.A0A0N5CD15"/>
    <dbReference type="WBParaSite" id="SPAL_0001576300.1">
        <property type="protein sequence ID" value="SPAL_0001576300.1"/>
        <property type="gene ID" value="SPAL_0001576300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="35"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="229"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001576300.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51173" checksum="1757A66A63FC54B9" modified="2015-12-09" version="1">MASSDITPKFKMINEDFVLSNDIWNEREREPIDYQLNDLYMVRFNLLKDRIHSSAKKQYGEDIKFSDYFDLEDENSGLLCGVLQLKLKERKSIITNIEVDDEALLTYEDNGFEEEIKKSDKDCLNLVTDDYIVKLSNIDIYNNSHGAVVGIYGHKLDNGNSFFVENIIYPEPALQQERLEAKEETYMCFISDLKFSHGKTSERECYLNFLSTCFQEGGTNLPEDIKNIFKGIERIVIAGGTFDDSDFYKRSYNILDLKDPLITHKQLVEADKYFKSLTNCAPVLVMPGICDIGTGSWPIQVPYRGAYTICSKLEKDFFLTTNPTFFETNGTTYLGMSGDSVTDILRIRDNKSSLDVMEQLLRYQHLAPTSPDHMSIFVSKSDDFMVLKKTPHVFFVGGQSHFDKKTIRLGDYDVLLLSLPSFSTTNTITFVNTKTLEAIPFTFNLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD34</accession>
    <name>A0A0N5CD34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ammonium_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD34"/>
    <dbReference type="STRING" id="174720.A0A0N5CD34"/>
    <dbReference type="WBParaSite" id="SPAL_0001578000.1">
        <property type="protein sequence ID" value="SPAL_0001578000.1"/>
        <property type="gene ID" value="SPAL_0001578000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000012">
        <property type="entry name" value="Rh type C glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001578000.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="48977" checksum="8BB45D38DD212DB9" modified="2015-12-09" version="1">MRENKKNNNFIIILSVLHIIFIVLFGIFTKFPGKSSNNNATENYIYFTDINAMIFIGFGFLMTFLRRYGFSAVGVNMLLACTTIEWSIIIRGLLSEEFMEHGYFTLTINSIIYGDISAAVILISMGAVLGKLSPIQYLIMAFFEVPAALITEHIIIEVLHVTDCGGSIVVHVFGAYFGLAIAKVLDRDGIKKSNHEGSIYHSDIFAMIGTLVLWIFWGSFNAALADGEEAKRRCLINTLLSLSAATIATFVTSQFVNQHRKFDMVHMANSTLAGGVAIGTASNLILSPFISLIVGTISGVISVLGYEYITPTLSKKFGIHDTCGVGNLHGIPGILAGLTSVVIAFIYTKEDYGDEYSSIYLSDKFGRSLQTQALYQVIGLGIAFISSIVTGAITAFILRLKIFDQVPDEDLFSDERYYHTPCDFDFTTRIIGHIDNVEITEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD75</accession>
    <name>A0A0N5CD75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD75"/>
    <dbReference type="STRING" id="174720.A0A0N5CD75"/>
    <dbReference type="WBParaSite" id="SPAL_0001582100.1">
        <property type="protein sequence ID" value="SPAL_0001582100.1"/>
        <property type="gene ID" value="SPAL_0001582100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001582100.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14269" checksum="C9AB29535049A506" modified="2015-12-09" version="1">MNNSTFLPTVVMQGDPDEITKSDTSYTILSRNNIQTHQTFSMDSTTYNQYLADKRKGFRCRGSLGPTIASAPSVELEDYRTPKPSVSVIKNGKSFDLSGIEQHNSNASESNGLIKVCFNSPQLYYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDV4</accession>
    <name>A0A0N5CDV4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDV4"/>
    <dbReference type="STRING" id="174720.A0A0N5CDV4"/>
    <dbReference type="WBParaSite" id="SPAL_0001604500.1">
        <property type="protein sequence ID" value="SPAL_0001604500.1"/>
        <property type="gene ID" value="SPAL_0001604500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001604500.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="56117" checksum="29BB84DBD9546CA6" modified="2015-12-09" version="1">MNAASCCLWKKKVQPRGQAATSEARLLLVNLFKVSESSNENDGFKRQRIEYLFMKYEVGEKIEVHEGELKSCRGVIVEVNDKIVVIKPLNLKKFNNQTVDVTTDKISKYFEIRDHIKVDNGRNAGDTGTVVKYDGKEVIFLSDLTKMKLKLYQMIVQFLLRENLEILTQMNTVVTKSPAQLMGKINNKTAKSMDLAKNELQINDQVTIVDGPFAQKKQFEETVVGTIKFIFKSFLFVQNTKRKVHAGFSVVRQRNVLRYGAKMPEQNTERLNFDDISKLKNGVLGATDNNKTEDIFKVPNLPGNNAAKTSSNSHGNRGGFNNHNKDPLFGKQIRINKGPYKGYYGVVKDVNGNIARVELHTTCRTINVDKSRCILVDSNPIPVRETSSSSYRSDYKSTADDEGLIENDNNKYTPCKTPLYGAKTPMYGSQTPNPFASDSDIWNPLSSPRHNSMNTDDDYNSFSYNDDLNIASVAPQTPGAFMNAAIPYGGVPMTPGIGIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE78</accession>
    <name>A0A0N5CE78_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBX domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE78"/>
    <dbReference type="STRING" id="174720.A0A0N5CE78"/>
    <dbReference type="WBParaSite" id="SPAL_0001616800.1">
        <property type="protein sequence ID" value="SPAL_0001616800.1"/>
        <property type="gene ID" value="SPAL_0001616800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="245"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001616800.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50236" checksum="EDA6D59EA5A523E1" modified="2015-12-09" version="1">MVWFEGTVSEAVSKCKSDKALFIVYLHHNYEKKNPETVRMEELWTLVDPSFFNTPYVAIKVEEDTVPAQQFSSIYKNPLCPSIYFIGSDGKPIEIITLIEECDETIFVDKVSNAFKKFAVDNGYVETEWSGMTKEEKAIHARKLIAERKAKKSELEQIEMKEKELRRRMDGKAMHEAKERARELELLEAAAAIKKQKQEDAAYKKKILEQMALERKDKQLEEEERLRNMNAVETPKPAVPKVTSIPTDVCRVQIRFPDGKTIVKEFQSKDKLQVLKDVIINEKRITTDFAIVQAYPRKELLEFEKDFLELQLTPSTTVLVIPNENKISSMPLIRSRNVNSMLKIFIYNPLIVILNFFLSFVGFSPISTTTNTQEQEQQSSEDRGNGVDKKETTNRAAANTSEVRQRGNIRFLRNSERDKPDDDKTETFNGNSTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEA9</accession>
    <name>A0A0N5CEA9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEA9"/>
    <dbReference type="STRING" id="174720.A0A0N5CEA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001619900.1">
        <property type="protein sequence ID" value="SPAL_0001619900.1"/>
        <property type="gene ID" value="SPAL_0001619900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000661">
        <property type="entry name" value="Cell differentiation family, Rcd1-like containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001619900.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36506" checksum="07F25B6253D9F1F4" modified="2015-12-09" version="1">MDMQNLSHSSTPSNSVSENLNADASENGSPDPELVKQLKQWIKDLHEPAKREAALHNLSKLSSKREEFPDLAVWLWNSYGTMTILLTEILLVAPYIHPPRLTNQMSTAVCNTLALLQCIASHKDTRLQMLHSNLHMFLYSFLHTTKTERPYEYVRLTSLGVIGALVRSEDKDVIALLLQTEIVPLCLRIMESGSDLSKTVASFILQKILTLDTGLNYICQTYERFNHVAKILKKSVENIASQRNSQTSRLFKQVVRCYSRLSYNAKAVHGLLEVLPDQLKDDTFKAEIDGDPQLKEAWTCLKENLEKAGKIPRPFVREPANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEI5</accession>
    <name>A0A0N5CEI5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEI5"/>
    <dbReference type="STRING" id="174720.A0A0N5CEI5"/>
    <dbReference type="WBParaSite" id="SPAL_0001627300.1">
        <property type="protein sequence ID" value="SPAL_0001627300.1"/>
        <property type="gene ID" value="SPAL_0001627300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09404">
        <property type="entry name" value="LIM1_MLP84B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001627300.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12735" checksum="C349B3A6A0CA4F74" modified="2015-12-09" version="1">MPFKPIEHPKCPKCGKSVYAAEEMVAGGYKWHKFCFKCALCNKLLDSTNCCEHAAELYCKQCHARKYGPKGVGFGIGAGALTMDMGERFGNTEVEMTNRPMTAEAFTAPINPQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEM2</accession>
    <name>A0A0N5CEM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Procollagen-proline 3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leprecan family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEM2"/>
    <dbReference type="STRING" id="174720.A0A0N5CEM2"/>
    <dbReference type="WBParaSite" id="SPAL_0001631000.1">
        <property type="protein sequence ID" value="SPAL_0001631000.1"/>
        <property type="gene ID" value="SPAL_0001631000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052284">
        <property type="entry name" value="Collagen_mod_leprecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF8">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001631000.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="59839" checksum="7B1F036E6DFAABA7" modified="2015-12-09" version="1">MIFLRSAYYFIFILVIWLPLHLYCTPEEPEITFEDLYINGKSAYSREEWGDCIAFMLKALEDFNFYLGEKIWCRQKCTKEIAGLNENHKINDDTNLLFHSLMYTQAQKALCLFRCQIWKFTEERPPMKNFQIYEDFQNRKPYEYLHFCYYKLGDLERAVKYSYTVLVGNSKNEDALTSLKFYMEQENFKKEMLVDALRKTYEESYINGVEAYNNKEWNQCVYWFESSLTELWEEDEKCRLTCEDRIDFSSIENDNPEISIVFTSIYYSVVSCQHNCIEKLSKVNGHQISNFLSSYFEYLHVCFFNENRGRDVGQSIENAILLNPSNMVSRQNKLFYINTYKDFGEKDLFTPSPKIVEYYIRYQNEKKLLDFVNQKFRFENLWYTAPTDKSIMDWSVDIKDYFDYSKLSTVLITDDECELLKLSGELEYLKAKNKFHKDELLEEIGERIAQKYETQVKFKSLHCNEEVECKRSGFTFSIEKETCSSLVNPSFPGCVVVFCNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEY4</accession>
    <name>A0A0N5CEY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEY4"/>
    <dbReference type="WBParaSite" id="SPAL_0001642200.1">
        <property type="protein sequence ID" value="SPAL_0001642200.1"/>
        <property type="gene ID" value="SPAL_0001642200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895873" evidence="2">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001642200.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14450" checksum="2185221D919A7425" modified="2015-12-09" version="1">MKFFHLVILLFLLIFYESTGARGGRGGRGNRGGGDHHGGRGRHDGIGHHDRGGHHDRFGYHGGGMSHESGYGSNSWRRRRPWFDRSGGGGYNNWNSYGNYGYGNYGYGENCRVVGLLFRRIRCFNYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF00</accession>
    <name>A0A0N5CF00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF00"/>
    <dbReference type="WBParaSite" id="SPAL_0001643800.1">
        <property type="protein sequence ID" value="SPAL_0001643800.1"/>
        <property type="gene ID" value="SPAL_0001643800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001643800.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21508" checksum="6398301044101DC7" modified="2015-12-09" version="1">MNSTAICYLNEFSAFSNSVDSITFISNVTVGLIHFGLTIFFITAQILMFISFHKIPKERYHNTPLPLMRHNGVVSFIQQLCHLVTSIKTIFLMRWKPIIIEIIGGILESAYLCVTVEVCWQAEFFNIYETQLGALIPQIMYIIISGANTTFTLFSVRDIRKSVSGICCSKPIVQVSKLGKAQIKKIKVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF39</accession>
    <name>A0A0N5CF39_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="20">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with sig-7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="20"/>
    <dbReference type="STRING" id="174720.A0A0N5CF39"/>
    <dbReference type="WBParaSite" id="SPAL_0001647700.1">
        <property type="protein sequence ID" value="SPAL_0001647700.1"/>
        <property type="gene ID" value="SPAL_0001647700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16 20" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="22">
        <location>
            <begin position="234"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1492"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1562"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1492"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="1520"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1577"/>
            <end position="1779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001647700.1"/>
        </source>
    </evidence>
    <sequence length="1787" mass="196718" checksum="FC16D5F18C3A5940" modified="2015-12-09" version="1">MSLIGVDFRAPLRDVKRVQFGVLSPQEIRNMSVCEIEHPEIYDNGKPKQGGLMDPRQGVIDKRGRCMTCAGSMIECPGHFAHIELAKPVFHIGYLTKVLKICRCVCYYCGMLLVDPNDPVVQERLDKTKNHFRNRLTTIYELCKAKNVCAASDSLTKNEEGEITRGDRRVSCGRYQPNYRRTGLEIWAEWKKLNDDKEERKIPFTAEKAMSILAEIPDEDCSILGLNPLFARPEWMVVSVLPVPPLCVRPAVVTFGSARNQDDLTHKLSDIIKTNNQLKKSEQTGAARHVVEEDIKLLQYHVATFVDNSIPGIAAATQKSGRPLKSIKQRLKGKEGRIRGNLMGKRVDFSARTVITPDPNLPLDTVGVPRTIAQNMTFPEIVTPFNIDKLQELVNRGDSQYPGAKYIIRENGTRIDLRYHPRAADLHLQPGFKVERHMTDGDIIVFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSVTTPYNADFDGDEMNLHLPQSLETKAEIAEIALVPRQLITPQANKPVMGIVQDTLCAVRMMTKRDVFIDHDKMMDLLMFLPSWDGKIPQPAIIKPKPLWTGKQLFSLIIPGQVNCLRTHSTHPDEEDNGPYKWISPGDTKVLIENGELLSGIICSKTVGKSAGNLIHVVVMELGHEVAAHFYSHIQTVVNAWLIGIGHTIGIGDTIADKVTYQNIQNTIRNAKREVLEVIEKAHNDELQPTPGNSLRQTFENQVNRILNDARDRTGGEAQRSLTEFNNLKSMVVSGSKGSKINISQVIACVGQQNVEGKRIPFGFRHRSLPHFFKDDYGPESKGFVENSYLAGLTPAEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYDGTVRNSIGQMVQLRYGEDGLAGEWVENQNLPTIKPTTLEFKRRFKLDVGNEKMINRWYTESVINDITSSTEAVRLIEEEFATLEKDREVLRKIFPTGDSKVVLPVNLDRLIWNAKKIFHVNVNEPTDLSPITVINKVKTLCNKLVIVQGEDSISKQAQHNATILISSLIRSVLCSRKVAEEHRLSQSAFDWVIGEIESRFNQAIIQPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKEIINVSKNPKTPSLTVFLKGAAAKDAECAKDVLCKLEHTNLKKVTANTSIHYDPEPKDTVVEADRDWVPVFYDINEKDTANCNPWVLRLELDSRKMTDKKLTMEMVASKINAGFGDDLDIIYSDDNADHLVVRIRIIKGSSSEAEDSGQMSDEILLRYIEHNLLTDLSLQGIDVISKVYMHKPTTDDKKRVILTPEGGFQKISEWILETDGTALQRVLSEENIDASRTTSNDICEIFQVLGIEAVRKAIEREMNNVISFDGSYVNYRHLALLCDVMTAKGHLMAITRHGINRQEVGALMRCSFEETVDILMEASIHAECDPVKGVSENIMLGQLARAGTGCFDLVLDSEKCKHGMEIQSNIMIGGDTYFAGSSVMSPSTYAQSPQQTPWNSGVTPGWEGGAAWSPHGSGGMTPGGAGFSPSTSDNGFSPSYGGDYGSGGFSPVGGMSPGGALSPKYEEIGHGGYSPASPNYSPTSPSYSPTSPSYSPGGISPMYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPSSPAYSPGGTSPAYSPTSPSYSPTSPSYSPSSPAYSPGGTSPAYSPTSPSYSPSSPIYSPGGTSPAYSPTSPTYSPSSPSYSPGGASPMYSPTSPSYSPMMKKKDDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFG6</accession>
    <name>A0A0N5CFG6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFG6"/>
    <dbReference type="WBParaSite" id="SPAL_0001660300.1">
        <property type="protein sequence ID" value="SPAL_0001660300.1"/>
        <property type="gene ID" value="SPAL_0001660300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001660300.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10368" checksum="C89E5BC77F9604C6" modified="2015-12-09" version="1">MSNIKHFHLILYTALIYLLNTIAILINNICFLYYECDIYLHLIIKYYKLLSLSCDVILPFFLLKDIRICFLSLFENGKIYVRKFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFV0</accession>
    <name>A0A0N5CFV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM91A1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFV0"/>
    <dbReference type="STRING" id="174720.A0A0N5CFV0"/>
    <dbReference type="WBParaSite" id="SPAL_0001673300.1">
        <property type="protein sequence ID" value="SPAL_0001673300.1"/>
        <property type="gene ID" value="SPAL_0001673300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="395"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001673300.1"/>
        </source>
    </evidence>
    <sequence length="821" mass="93372" checksum="4BD3785A0F58E3B3" modified="2015-12-09" version="1">MSLSIDDAIRKNIAWKELPQELVALLGGSQKEYDKLVLDFSVKNQLRFKGNLVEKQGKNEDGYYDVVISYSQKYLMLYPYHLSNIYVSKGITPFIYYSQMIEDTIKTERSYDSLPNFTAADVLRLFGIGRNEYMDLVYQTKSKSGIFRRKTNIKDLLPQRPINILIEPWFMIELGVVHDTELRSLSKKERDVMDLILDGGSQLAGTLDKSVLQILYQKTMIYLSVPIQNEDYVYVPPLDGFVMNRVTGDCIETLLYKIFVAIDEQTTIKELSDVLDVDLQLVKNAISVFCRLGFAKKRVTGLENFALHKTWADYMVFNDIVITPTVETLSTSSTLFDLSDLTNSLVSPNATEFDDDELIAEVENTLSNSSTNIKNIAASLPSPGNNTSGSGSDQSKRIGFIFDSTLTAFLMMGNLSASLKHHAVTLFEVGRLTDEAVGSFVDELEHVNFFSEGEAQHYSEHAKTLRQTIINLREIGEIDLLRGESLLSLDKNVRKKMMEKSYKFIVTMGPLSTEACSIPPLSIPYFGATTVTFLSPWFKLHIYELSKNGPPSLWIPMGERLTRIPNEFVNYNKLIVYSNTHEPSIVSIEKCLSSINDSLTTAPVMIQAYSDIIDDSEIILVPFPFENTNRERSFENHPSIIKLNKELNLNSLCGYIVLLQLTNCDTKENISLDGDSINITSSIESKSSNQSSTYLFERTNKHSIVNKDPRRVYNCKDSLNEYEKFEDFVIFDIVFGVPLFNQKLNEIIFERIKNKSLFKDPQNTQDCAFILQNQIASIKEIYNRFSISKSEIPFNRSETNEIPFPVKKLFFNNTIGTLNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFW7</accession>
    <name>A0A0N5CFW7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFW7"/>
    <dbReference type="STRING" id="174720.A0A0N5CFW7"/>
    <dbReference type="WBParaSite" id="SPAL_0001674875.1">
        <property type="protein sequence ID" value="SPAL_0001674875.1"/>
        <property type="gene ID" value="SPAL_0001674875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001674875.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8249" checksum="EA5E108465F5290B" modified="2015-12-09" version="1">MEDFRTLKARYCSVPGRVTNQDQIISRVDQVIETMNEELQFSNYYQHMRVFLDQAFSGIAFIYFFIVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG21</accession>
    <name>A0A0N5CG21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG21"/>
    <dbReference type="STRING" id="174720.A0A0N5CG21"/>
    <dbReference type="WBParaSite" id="SPAL_0001680000.1">
        <property type="protein sequence ID" value="SPAL_0001680000.1"/>
        <property type="gene ID" value="SPAL_0001680000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000409">
        <property type="entry name" value="TRP (Transient receptor potential) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="14">
        <location>
            <begin position="304"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001680000.1"/>
        </source>
    </evidence>
    <sequence length="1153" mass="131548" checksum="98DD9083AFB099CE" modified="2015-12-09" version="1">MTEEINKTTISGKKTFVPFDRDALGRGDEQQNGGISSGTYDGNLTYSGGIIGESFDVIDNTTIPMSFSTPAMSEAMRSPFQRRNESLPSTSSTGTTTTTLNGSDSLGVAGDVFSKERKPWNLVGSKPSLTFSPTTNLLAPPSNDSPSKDMSSSEKAMQEKQFLLACERGDIGSVRKLLECARKHPEYLDINCLDPLGRSALHIAIENENIEMIEVLLDANIETGDAILYAIGEENVEAVEIIIEHLEKINKFNPETQGVEINEHSAFTPDMTPIILAAHKDNYEIIKLLLDKKATVPHPHDIRCLCKDCTYAKSEDSLRLSRSRFNAYQALASPSLICLSARDPILYAFELSWELRRLSYVENEYRNEYQELSQKCQKFSVNMLDQVRGAKELEIVLNHTTNAWGEVAERYTSTEEVSHTLARLKLAIQLRQKRFVAHPNCQKLLTALWYDKLPFFSNRNLIYKLLIIIAVSIAYPILAVSYLIAPKSCIGSFIKKPFIKFICHSASYCYFLFLLILASQRIDYTFFFDLFTNDINGSESSKNEDIDRKETRGPPPTPVELAILIWVMGFIWVEIKQLWDSGLHEYMYDLWNILDFITNSLYLCTFALRAVAYYQVESEMRDPNMQHIGRKLHRKDWDAWDPTLISECMFATANIFSSLKLVHIFTVNPHLGPLKISLGRMVIDILKFFIVYCLVLFAFACGLNQLNWYYASMRQQECLKYKELLKMEDRINLNDVEIKNLEESCDPKYRSCASLFNTVETLFWALFGLIDLSHFNLKEEHAITEWTGKTIFGSYSCCSIIVLLNMLIAMMSNSYQYISDQSDCEWKFARSKLWMEYFDDTATLPPPFNIIPSPKSFYYISRWLCENIFSFSKKLQLVKQKSMRNILILKSVNQKENYYRRTLRVIAERESVFGFVSKNLIKRYIAQMQRRKQLNEGVSEDDVNEIKQDISAFRFELLGIFKNAGFVTGHSDITQKINSRAKRRAAMAERRMKGSSATFNLPIPEEWNSDKNSGGDSKVAHQNRPSRSDSIVNLANSLKLSNWYHLNKLRKRVSFRKSSGSSNTLSIDSSSGLMLSKKQSLSSSGFDRKESILEESEQDLRNELESESSFLKNTTEGGTGKRGSADAILKRLKFRKTNKQSCTVDGTTEELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG76</accession>
    <name>A0A0N5CG76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG76"/>
    <dbReference type="STRING" id="174720.A0A0N5CG76"/>
    <dbReference type="WBParaSite" id="SPAL_0001685500.1">
        <property type="protein sequence ID" value="SPAL_0001685500.1"/>
        <property type="gene ID" value="SPAL_0001685500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045005">
        <property type="entry name" value="BPM1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379">
        <property type="entry name" value="BTB/POZ AND MATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379:SF187">
        <property type="entry name" value="OS07G0655300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="184"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="369"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="530"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="692"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001685500.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="93345" checksum="C432F15B8EEAB157" modified="2015-12-09" version="1">MGNKGSKPFDGFYTITEDVNYFKYKCTIRNFSRRPEKTGEYFLSPTFEIGSKDRSEWCLLIYPNGGKEDTKEYVSVFLYLMSGKTKARIKFSILNDKEEEKNVRFDTKFNDFLKNRSWGYPDFINKDFLIDKSNGLLINDELTILCEVEITDFEYEMLVEKTGRGHTRGRSFAGFYSIQTDVNYFKYEYSIENFSRRPEKTGEAIISPTCVDGFGNKSKWCLYIFPNSDRKETKEYVSVFLCLMSGKAKAKFKISILNDKKEEKNVLYAPISIDYDEKENNSYGFLKFVKRDFLLDESNGLLIKDKLTILFEVEVIDPKSEKFLEEVCMNHENSKPFGKSSVITLSLRLILRYLPFKDGFYNIHTDVNYFKCKYTIQNFSLRSGKTGEHFLSPTFGIETKNRSEWCLIIYPNGYSEDSKDYVAVFLMSVKAKKAKAKFRFYILNKKGEEKNIFYCRANEYFKGVCWGVRKFIKKRFLLDESNGLLINDKLTILCEAEIIDSENFVEKIGMDNDNNKPSDVFCSMQIDDNYFKYKCLIQNFSQRSEKTGEKIISPTCVIGSKDRSEWCLYIYPNGDFKDSKEYVSVFLILLRPGEAKAKFKFSILNDKEEEKNIFYGGVYYYNKDNGWGESKFIKKEFLLNESNGLLINDQLTILCEVEIMNHDNPETSINVTIPRSKLSLDYANLFDSTLLYDCVIKVEDAEIQVHKAVLAARSPVFYDIFNSTSDQSQTNIIEIKDFRVDVVREMLNDGLIIVPQILYIFVSGSNTIFTFCIVSQVRRSIFHCVKPRKRTTTTKILKFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGI0</accession>
    <name>A0A0N5CGI0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGI0"/>
    <dbReference type="WBParaSite" id="SPAL_0001695600.1">
        <property type="protein sequence ID" value="SPAL_0001695600.1"/>
        <property type="gene ID" value="SPAL_0001695600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895839" evidence="2">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001695600.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19884" checksum="C2AFF003431F22A3" modified="2015-12-09" version="1">MKDISKMRFMKYLTIIVLLAVQYSFQDSSNEVSSSGDENDVSADLSEVATSPNELLLDSTGKTAASSLANDVEQSTIEKSGKSKNFLKRAFTKDKTKKRLKKAKEGAKKAAKFAGKGLKMMFSGIKKGVKGLAKNMKSKSSESSDSSSSEEDREKRSLFKAFLGKPASNAVKHVGHKLLGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGQ8</accession>
    <name>A0A0N5CGQ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGQ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001703350.1">
        <property type="protein sequence ID" value="SPAL_0001703350.1"/>
        <property type="gene ID" value="SPAL_0001703350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001703350.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7926" checksum="458DBD7B5EF7FB86" modified="2015-12-09" version="1">LPTSHFFSKLLKSSTIFYNIISLMSRVLLSINTYYLFIYIIYIFFPYISMPLIRLSSINSTSPFYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGR0</accession>
    <name>A0A0N5CGR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CGR0"/>
    <dbReference type="WBParaSite" id="SPAL_0001703500.1">
        <property type="protein sequence ID" value="SPAL_0001703500.1"/>
        <property type="gene ID" value="SPAL_0001703500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="746"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001703500.1"/>
        </source>
    </evidence>
    <sequence length="1284" mass="148441" checksum="503737331D13C037" modified="2015-12-09" version="1">MASNLLTIAENARKEGLKKLRNLPPLKIKREPSTEDSFISTPSTANNNPHTGNDDGESVSFNEFNPLFQSPEVQSISRKSIGEISNDVRENIRKKAKTALEGKRGSIQLQKRLLRSKTLSTNIPKQIFENDGDKMDSQIERVIKLGEKYETKKESNNVIDSEIENRFVSGYFDRDLIQDNNDILFEYAPGIPINIDIEEVKKLIVIMEEKFTMDDLESGNFNYDVKNKNINKLKQRLPKKFITNNNSILGIDENEFCERKVLKYDRAEWEERSLIENVWGVRKDSQLIGGSNYKKNHYENIKIYLSKVKLHHHWLFSKEHVLCRKVEEVYEILLYKATFILKDIKIYLASKSIDGDINEIEKKIENEVNEYGKCCDEIQLYWENLCNLRNEQGYQRTSLTLTVKEVEEQDLSIFTPVIQNFYRNPIFSITYNKENIKIYDKKELVEEDQDHTQTKKEIETEKDFESYFMSLKKCEWEAQILFNDIFVCRTQQKCINKNFEIIFNEEYNLSVHDVPESIVIVLCERFNRGVFKVIAKIGIPLEKEDENPDNISCNHFASDIVYESLSGTVGAGGVGREPLSGVLFTKLDGYGILTGEEVKERNDKLNHLSDNGDFQLIPAETRLDNSDLNEDDARITALRMRFLKNQLLGSIEKPIPIYASEMQSRFYKVEETTTEEYGKFGFGIENHKLSSMHYAIKLRTELMQNMESNKRKIKTYSDIVKEETIPNLFSGFSTLFGNRDVSRKLKPMRNEIKKHVTSGIFKFKFIINIQSAINIGEKIDGTPIESFVEITFQSQVFKTKICPGKNPKWQETIIITFDNTSLENKDLNSIVEKFTIRIYDYITVPLKHDDREINTIHEQIECRYLGKTEIPFYTIYMNGKIDGLLPIHRTTFCNGYTFEGNSYLKLMISLDPLIASPVHENISTNVSIEEENIIQKYISWKKRCQALYPNRKYKGLVFNSQGKSLLASRYIHAVKPPLLLDYLIADKLSLIKKAIDIVKCLPTIEDPVMFPGICDLWTNVDQTLTIGCGDEEEHALMLICWLKYYQIDGFLVLGNALPEGLRTAYVIVQLDDKLYIINPVEGFLWDIKDAYVPILSIGTIVTDKNIFGNIQKHEEPHYMIFDFSREDCWKKMFDNDVPESKFITVQNEAIIYQNISDSLVIELKSSLERDAKAKIDELRQHGIPQWNILVARTLKDILSDVNVIDNSKEIEKRLYDNFGSIFKINAIILKIPFISRKQIISEILSTKIHLNSDIGVQFAISIHLIPYMNNILQCNVGLASLIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH09</accession>
    <name>A0A0N5CH09_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH09"/>
    <dbReference type="STRING" id="174720.A0A0N5CH09"/>
    <dbReference type="WBParaSite" id="SPAL_0001713400.1">
        <property type="protein sequence ID" value="SPAL_0001713400.1"/>
        <property type="gene ID" value="SPAL_0001713400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001713400.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36616" checksum="72BB58DC6014B2F8" modified="2015-12-09" version="1">MSKPTVGINGFGRIGRLVLRAAVEKDTVQVVAVNDPFINIDYMVYMFKYDSTHGKFKGDVTHDGSNLIVRQHGKEVHTIKVFNCKDPAEIQWGSAGAHYVVESTGVFTTIEKASAHIKGGAKKVIISAPSADAPMFVMGVNHEKYDAGNDHIISNASCTTNCLAPLAKVIHENFGIIEGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPDVSVVDLTARLEKPASMDEIKAVIKAAADGPMKGVLAYTEDQVVSTDFVSDSHSSIFDAGACISLNPNFVKLISWYDNEYGYSNRVVDLISYINTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH12</accession>
    <name>A0A0N5CH12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH12"/>
    <dbReference type="WBParaSite" id="SPAL_0001713700.1">
        <property type="protein sequence ID" value="SPAL_0001713700.1"/>
        <property type="gene ID" value="SPAL_0001713700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896079" evidence="8">
        <location>
            <begin position="17"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="51"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="280"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001713700.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="45136" checksum="00A3940D3E3610E2" modified="2015-12-09" version="1">MKITLIIPLLFSLCLTGSLVKKKVFKNYKKILPLKKPPPYLEKSGYVSISYPKKYEDNILKIFHNISTFTCLQYKVEKNRINGKIGINFYFTKKVNKVKRSYKLNKPTNVYLKNYVYKNMTKLSFYVGLALELIPEVARRDRRKYVSINFMNIKDSFKKYYMRTKYNYAYRQNEEFDIESAMLNTPYLGSINKTPTYKIKAHKNCLKTYNSSKLFTFSNFRRIYDLYCREKCDLTDNCENGSFPNPTCTHCICPLHFVGKKCEKLKPSEGYCGVQEQFWVIKKVNFLSNDNIEGECYYSFKTKEEKRIKIRIKYLILLNSNSTMDDPYMEIFYGRNKSKPDLTICNSVTNLNITSLSNEVYIYFHIPTVPNKLYLEFHEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHG4</accession>
    <name>A0A0N5CHG4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHG4"/>
    <dbReference type="STRING" id="174720.A0A0N5CHG4"/>
    <dbReference type="WBParaSite" id="SPAL_0001728100.1">
        <property type="protein sequence ID" value="SPAL_0001728100.1"/>
        <property type="gene ID" value="SPAL_0001728100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001728100.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16882" checksum="FB1214968398979D" modified="2015-12-09" version="1">MSNTERTFIAVKPDGVQRGLVGKILARFEERGFKLVGLKMLTASRAHLEVHYQDLKGKPFFPSLIDYMASGPIVATVWEGLDAVKQGRAMLGATNPLQSAPGTIRGDYCIQTGRNIIHGSDSVESANREIAHWFKPEELSEYTSAQAKWIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHW1</accession>
    <name>A0A0N5CHW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein salvador homolog 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHW1"/>
    <dbReference type="STRING" id="174720.A0A0N5CHW1"/>
    <dbReference type="WBParaSite" id="SPAL_0001742300.1">
        <property type="protein sequence ID" value="SPAL_0001742300.1"/>
        <property type="gene ID" value="SPAL_0001742300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="3">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001742300.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39797" checksum="51760162F9593A39" modified="2015-12-09" version="1">MPSWKKQNNPVPPYLIGTPGKYIRRESPPRIPTLDINPNIKSNIPNIQLTKISDNNKTSHRSSTISETSSHPSQNITVTSIRGIHNTNGLKKSSHRFELSSHSFANHHPIHGGQKDNLSNKPTLTSSVSIGNVVQHSNENEYKPINHIQIQQAPSLRSLPMINSCNNEELTLPANWSVEMTDEGLLYYVDHNNRVTHWVHPFARENLPYGWQKIFHPEHGVLYYNEYENITQTEHPGIAQDIDAIYESPSVQAIVQQPSAEKDEFIEEVSIINEEEVPQWLKLYASADTESDHLLNWNLFKLSQLDSFDGMLFKLFKQEILNVAQRYEKLRREINIELVNRRCDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI97</accession>
    <name>A0A0N5CI97_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI97"/>
    <dbReference type="WBParaSite" id="SPAL_0001755400.1">
        <property type="protein sequence ID" value="SPAL_0001755400.1"/>
        <property type="gene ID" value="SPAL_0001755400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001755400.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7636" checksum="F7375B6C2F8E4227" modified="2015-12-09" version="1">MHTIHNPVVPFVQTIHEELRPGAKIIVKGQIAEHHHHSQDFAIELLSGPHAVLHVNFRFDHGSHKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIA3</accession>
    <name>A0A0N5CIA3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIA3"/>
    <dbReference type="WBParaSite" id="SPAL_0001755900.1">
        <property type="protein sequence ID" value="SPAL_0001755900.1"/>
        <property type="gene ID" value="SPAL_0001755900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001755900.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15222" checksum="86E6BBDE74AF41B5" modified="2015-12-09" version="1">MPSETSPNFNDVSSTQMTTKRPGENCSTSKTPKTTSRSTSTVRTTVTQMTTKRPGENCSTSKTSKNTSRSTNKVRTTVAPRTTKSSGGNKGKHGKGGKHGKGEKHGKGEKHGKGEKHGKGEKHEKDGKHKEIRKKQKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B220</accession>
    <name>A0A0N5B220_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B220"/>
    <dbReference type="WBParaSite" id="SPAL_0000012300.1">
        <property type="protein sequence ID" value="SPAL_0000012300.1"/>
        <property type="gene ID" value="SPAL_0000012300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000012300.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7986" checksum="67B2F80C1C9F8774" modified="2015-12-09" version="1">MRNDENVAQSPPVTVVVKRGRDNSTFAEVGENSNLENNEHETTENDKKDTDLKERKGIWRKQDEIFVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2F5</accession>
    <name>A0A0N5B2F5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2F5"/>
    <dbReference type="STRING" id="174720.A0A0N5B2F5"/>
    <dbReference type="WBParaSite" id="SPAL_0000026200.1">
        <property type="protein sequence ID" value="SPAL_0000026200.1"/>
        <property type="gene ID" value="SPAL_0000026200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057001">
        <property type="entry name" value="RYYR-CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23674">
        <property type="entry name" value="RYYR-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000026200.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44517" checksum="052C5EBBA4447FE8" modified="2015-12-09" version="1">MNLQEDSNSQLSGFILENNDYIPKEDLYNILRNDIPQCYICLSTQSQKVRLFKWPRDKERRKSWCDFFEVDEEEILADFGNTFICSLHFDPSQFLYVSGKIFWKSDVSPLIVDPDSLDTKCYPWEKEESLKNIFEDEYKKLLACASKAFSDNSVITIGYRESNFRPTGVSKKHPVVILRDIRYPYFYYEFSHNRTNSRGTDFYYCLTCKKMKDKTGIKDNVRTISISDGRVVTSAHPFIRHHSHCSPGIEADEFMNDTGIECSGISTEVANESSFMDSKNVNNCQKIYEENHYSVDGQNLNDIMIHHNESSEFIEPSNDNIVNTVRNKKENGCRRSQKHKPRRYLSLYRPYGCRKVLFCCICLQKFKTVPELANHLTTKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3T7</accession>
    <name>A0A0N5B3T7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3T7"/>
    <dbReference type="STRING" id="174720.A0A0N5B3T7"/>
    <dbReference type="WBParaSite" id="SPAL_0000073900.1">
        <property type="protein sequence ID" value="SPAL_0000073900.1"/>
        <property type="gene ID" value="SPAL_0000073900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="82"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000073900.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39728" checksum="7C1CFCC0F455A58D" modified="2015-12-09" version="1">MDNNTTLDFLSFNNPPGDGNFEPSFSENTRNFSSPHRNNTNSPNDGSKKSGSYLDSIQNYFNIDTNMFLNRLYFSIVPLKKSNFILDVIENNPDIYGPLWILLTLVLSIGVTNSLVHFFNTYGEQSTEVDFQMITAVFTLLSLYITLVPLGLYFYMSYNGAATNYTYMEVLCTYGYNLAILVPISVFYHFNFSILRTSLIIVAIIITCTVLYNTFWPAFKNLGKRNEAMMVMVLIIILQIVVVSLLKVYYLDTLSPIKMADDKSSIIFPHTQGSSLVQGINVNENDTLAHSDKQNDEVTTVPQTLTNTVKLAAEATKANIDNKIVVQEEKKEGDKRLANDSTVPSIITPSIALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B495</accession>
    <name>A0A0N5B495_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B495"/>
    <dbReference type="STRING" id="174720.A0A0N5B495"/>
    <dbReference type="WBParaSite" id="SPAL_0000089700.1">
        <property type="protein sequence ID" value="SPAL_0000089700.1"/>
        <property type="gene ID" value="SPAL_0000089700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF7">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000089700.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11216" checksum="B33D2EF7FED0F1F9" modified="2015-12-09" version="1">MAAINVDPPGSEMPAAGGKSNHKIGNPGATKIAFKIKSSNNTHIRIKPVFGFVDAGGAADLEITRLNGPPKEDKLVLQYKEAPAEATDPAAIFKDGPAGGEVIIPVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4L3</accession>
    <name>A0A0N5B4L3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4L3"/>
    <dbReference type="WBParaSite" id="SPAL_0000101400.1">
        <property type="protein sequence ID" value="SPAL_0000101400.1"/>
        <property type="gene ID" value="SPAL_0000101400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000101400.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8463" checksum="954AA49EE495454B" modified="2015-12-09" version="1">MDFEIKYESTGGIYTDNGMRNYQYCGYEQNEDYSPGDVNTPDSTTAPYFNDNARGMFQRDFYQPYHVNQAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4M0</accession>
    <name>A0A0N5B4M0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RPA_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4M0"/>
    <dbReference type="WBParaSite" id="SPAL_0000102100.1">
        <property type="protein sequence ID" value="SPAL_0000102100.1"/>
        <property type="gene ID" value="SPAL_0000102100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000102100.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27780" checksum="DB808B9A1A7F9B8D" modified="2015-12-09" version="1">MFKTSPPTICSTMKKGDIVTVTGKFQPMQKTRRLQLTSIKVDLKKEVDLDNFKEFIKVELQFCQNFHNYIGDFIHKPDPYAPTLLRRLVFTFTDNTDPVFATPASTPASGQSYQARRSSAPTPASLQRTVSYPATSTSSTPRGRPLSDISNPLKRQISVPDIGTPCSIERGPEEKKAKSDHLEMYLLSLMETKKDEDKENWNGMTFQEFVDKSLHSDVEVKEAIMNLSIQRKIKSTGPHVFDFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5M0</accession>
    <name>A0A0N5B5M0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4HB_MCP_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5M0"/>
    <dbReference type="WBParaSite" id="SPAL_0000136400.1">
        <property type="protein sequence ID" value="SPAL_0000136400.1"/>
        <property type="gene ID" value="SPAL_0000136400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000136400.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40379" checksum="57BB299243CEE29E" modified="2015-12-09" version="1">MDSVLSISILQRFKVFLILINVVWFLTTIIGLIVLLQPYVKLAISVKDDYKVIVDTFQNFDSIKTDTQELEKKAKDHEKILNGININKILSEKSVDEILGQLSNVVISSKTIEDFRAKKEDDFKNSIIEDINNFGTRLTTIHKPEGDIAEIYANIELVGEFDRNITLLAEDLKSILGENEAINEIIRLKDKIMSKIYPLIDMKKKYNNFFNIIFIHVVKKKDKDAKISYGSDDLENGIILMLHSCYYFDINVKDMTSSNSFADNLRDKITAQEIKSKLFDNQDVKVILKQDGESGKDIDVCPNWGKNQKGYIILFGIIIVSSIILFIAFINFSIMQCCGCHINYNIVRYCKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6C6</accession>
    <name>A0A0N5B6C6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6C6"/>
    <dbReference type="STRING" id="174720.A0A0N5B6C6"/>
    <dbReference type="WBParaSite" id="SPAL_0000161600.1">
        <property type="protein sequence ID" value="SPAL_0000161600.1"/>
        <property type="gene ID" value="SPAL_0000161600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894008" evidence="3">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000161600.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43318" checksum="6597A24CB6392327" modified="2015-12-09" version="1">MLVGLLLALICFSTNKGDDTLLGVQALWRHGARSPEVIFDYDPHKNDWPVPLGELTTEGMRQHYDLGKRLMQRYGEEYKLINTSYDVGEIYVRSTDVNRALVSAYSNLAGMFSESKNTYPDGNWPSPWTPIPVHTVNDTDDNLLNPTFYCPRLYQLSDERLQRKQFLIFENTFSSLFDYLTLHSGVNITDYKSLETLYVTIRVEKYFNYSQPSWVTDDIFKQMELLVNSSINYSYGCAGFGLPEDKELISLKQGYLVWQMIDNMKKMIKNKGIEKFIAYSAHDTTLMAFANVLGAKVEIMGQGIIDFAASFLLELWKDGNENYYIQLFYANNAYGDFTPVTHLIRGCINQDKCSLDDFENGTSDYLYHHPQDHCTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6T5</accession>
    <name>A0A0N5B6T5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6T5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6T5"/>
    <dbReference type="WBParaSite" id="SPAL_0000177100.1">
        <property type="protein sequence ID" value="SPAL_0000177100.1"/>
        <property type="gene ID" value="SPAL_0000177100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CpG binding protein C-terminal" evidence="11">
        <location>
            <begin position="64"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000177100.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41825" checksum="E990DD4E66B72CC7" modified="2015-12-09" version="1">MDVESNAEPPPVDQWDESKIFSEALRQGVAVKADEVRRCLWLECDNAAVSGSKYCSYECGKKLAHERLVRLAPYIIEDGEKFSFIKENYKKEIETLKGVCRTKLENMNKAAECAKMLVGFITQQLPLEYDDKENGSNASRKDYILCMCCGENLEAPLYGNHITKCLNRKEREAYYGSEEKGNLLLNILCERYSSRFNSYCKRFKIICPEHPCNDIDDELKVCSYPDSFDDAIRKDGGFFFLTFSPQFFKGPFCTNGYGTCPDHPNWYRYTLAVIDAYRFGELEKLNEARTMIGKYNTFINTRGNVFNSISSKQVLEKFYKDSINNCPKTLRKEEVKKEIDPSGDAGNKIKLIHPDAEAISDAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6W0</accession>
    <name>A0A0N5B6W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6W0"/>
    <dbReference type="WBParaSite" id="SPAL_0000179600.1">
        <property type="protein sequence ID" value="SPAL_0000179600.1"/>
        <property type="gene ID" value="SPAL_0000179600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894041" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000179600.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19011" checksum="CC808CF8E451F31C" modified="2015-12-09" version="1">MNVFILVPYTFALFSVSQGGMGNVWGRVWDGTKKFFFGLWNRHPASRSLYEFLDRDVDPCDNFYKFSCEVLEGKYNDQSRAINTFYNLYKRCEKELPEDKIEDCKSKISDFGIYAMSSLYLKEDKTKEKNNKEFESITLSIFDKIKEEFKLLIDEKKRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B848</accession>
    <name>A0A0N5B848_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B848"/>
    <dbReference type="STRING" id="174720.A0A0N5B848"/>
    <dbReference type="WBParaSite" id="SPAL_0000222100.1">
        <property type="protein sequence ID" value="SPAL_0000222100.1"/>
        <property type="gene ID" value="SPAL_0000222100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07093">
        <property type="entry name" value="ALDH_F8_HMSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000222100.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55178" checksum="7E8F70E2C2AA85FB" modified="2015-12-09" version="1">MANTKNAIQYLLSIKDGEPKKITNFINNEFVETDTYIDSINPATGKVWLKVPNSTSIDIDNAANIGENAFKIWRKMSIQKRCELLVKISNIIEENLEEFAIIESRDQGKPISLAKVIDIPRAIHNFRFFASTIVGKTTVSTNNTFPVKSINYVKNDAIGVAGLISPWNLPLYLLTFKLAPALISGNCVICKPSEITSATAWLLCHAFKDAGFPNGVVNMIFGDGINAGEALVRHPKIPIISFTGSTKIGKHINTIAAPMLKKVSLEMGGKNCGIVFPSVDINEVVPQIAKSCFINQGEICLCTERLFIHEDIYDEFIKSFVNEANNMTVGDPTENYTLGAIVSKVHFDKVMSYIDAAKNDSSINILCGGQYKYEIGHKCENGYFIRPTIIAGADDDSKFMKEEIFGPVVCVTTFSTIEEVIERANNTPYGLSATVWSKNSDELQTVGDELRVGTCWLNCWLVRDLNMPFGGTKESGIGREGAEDSIHFYTEQKTICLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8L7</accession>
    <name>A0A0N5B8L7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8L7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8L7"/>
    <dbReference type="WBParaSite" id="SPAL_0000239000.1">
        <property type="protein sequence ID" value="SPAL_0000239000.1"/>
        <property type="gene ID" value="SPAL_0000239000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="7"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="112"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000239000.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35525" checksum="56C8228715EB861B" modified="2015-12-09" version="1">MAMISNVFIADEIEKECIETLLQNGISVTTRKNETKDELLEILPLYDAVIVRSATKITSDLIEAGAKGRLKVVGRAGTGVDNIDIPAATKNGVLVMNTPSGNSQSAAELTCTLILSLARNVPQADISMKEGKWARKNFMGEEVGNKILAIIGLGRIGQMVASRMQAFGMKIIGYDPFISKESAKQKGIQLLSLDEIYPIADYITVHVPLTKETENLLNRETLFKCKRGVKIINVARGGIVNEEDLVLAIDNGQVSGAAFDVYVEEPPKYYDLIKNNKIITTPHIGASTIEAQNRVAVEIAQNIISLNEGKENFGALNANEVLLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8W8</accession>
    <name>A0A0N5B8W8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8W8"/>
    <dbReference type="WBParaSite" id="SPAL_0000249100.1">
        <property type="protein sequence ID" value="SPAL_0000249100.1"/>
        <property type="gene ID" value="SPAL_0000249100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893930" evidence="1">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000249100.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43331" checksum="57E91B6809C370C3" modified="2015-12-09" version="1">MNCFAIFLFFYFVDVGASTYEIHQDYKCRVNRLIGVNEKYDSHVTFLLTQDCYLFLKLDWQMKYFLKRGLDSTKVKNNNCLQHTEKHILFTNIDKENLYIIRFYKASNVTVEGVVNRINYIKALRKGSSEGIKIKYSATDEQERNDYIETWPISINISPQIYHFCIVVDNEEVKLKCLNQWSNNSFYVSTYGLKSDKIFKLEEQSKMYGMEYDADSSYGLFFNNDDLYAYKSDEKNGDFIPVFITDKTKMNESEYDVQKFIMHPPLKGHIAKYIITTINNAGLILNLCIPKADKKSDKCKAHFIEEGYNSRKSACLYNYEFSKNTYFISGVIPLKNHERTPTTVFRKDECIKEFEKLIEDAKNDTHTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B919</accession>
    <name>A0A0N5B919_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B919"/>
    <dbReference type="STRING" id="174720.A0A0N5B919"/>
    <dbReference type="WBParaSite" id="SPAL_0000254100.1">
        <property type="protein sequence ID" value="SPAL_0000254100.1"/>
        <property type="gene ID" value="SPAL_0000254100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000254100.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57174" checksum="3C1B7387C9515904" modified="2015-12-09" version="1">MMKCSFHHKNVNNNERASVSPLISLVQESLLKKNQNSSDCNKSNTTTPSSYKKTLGNRYIPLRQTEEEWSKRWLNDGSSGVIFENNTKNNSKGKFVNLNEKGLLDMVLRNEMLNENISSPIRCTDYTITHQPSLLIKPKPPPLLSFGSGDGKENTKMNNCSLTTPYPFKGATVELLSMKMKYSLGVNDLPLSLIETKVDRNNYNEKPLDWSSKNLLACGIGKNVYLKDYKEPEFYKFGSDREYTILKFNPSGDKLFLGSGGGYSRVVDVTDKSIVTKTYGRIFDDVTDVTWLDDHTVGLSTPHGYIIFYDTRDYQMNPLVFYDCNCSVTNVEINKSGRYLASGRACSIVNTWCVRSRKVIDSFLKHDDMITALEWSNYSDNVILSGGKCRRLYMRDINVPENLRYIDTGYPINGIHMMNDGKNVITTHGFSTSDVVVWNSLKLNPATIISCNGNRTVHSAMSPDRNILCTITSCGIIFFWDMKAKSGKNKNFHRSKLDPHYFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9V1</accession>
    <name>A0A0N5B9V1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9V1"/>
    <dbReference type="STRING" id="174720.A0A0N5B9V1"/>
    <dbReference type="WBParaSite" id="SPAL_0000282100.1">
        <property type="protein sequence ID" value="SPAL_0000282100.1"/>
        <property type="gene ID" value="SPAL_0000282100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000282100.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42186" checksum="55571815F905C9E4" modified="2015-12-09" version="1">MSLGLSDIYYNDSLISTTTVTSTEFKDTASGTIFLSFCMMIIVTVGFFGNGLIVIAFSRDGHLRKKYFLLIVISSLYACGSLFFTLDIYHLYRHEVMKDPICTIHAYAISTLSVGGIHQLSVLSFERYVGVNHPFILMKLPLRTKILFASLAFIWTLLTTTPPLFGWSKYKVLDDSLHYCVFDYLSNERSTQEYIMYLFFNGYIIPLAIIGFSNYKIFLTTKGVVTSRKTDVYHKRLRSLTSTSTYFSETEPDSNLQELAKICETSGLNDSEFQNSLLVYDRQQRKCATVIFYCVGSFIISWTPYAFTSIVWNIIFNFKLNSTFVLLTAIAAKMFVIWNPIIYGFMDETFLNECGKILTTRFKYWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA39</accession>
    <name>A0A0N5BA39_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA39"/>
    <dbReference type="STRING" id="174720.A0A0N5BA39"/>
    <dbReference type="WBParaSite" id="SPAL_0000290800.1">
        <property type="protein sequence ID" value="SPAL_0000290800.1"/>
        <property type="gene ID" value="SPAL_0000290800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000290800.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="76292" checksum="5C29C3F80CF6FD49" modified="2015-12-09" version="1">MSTTKELSAQLEDFVWGRVDENKYLQNVGACTELGDEKLLKKVDLMQENLNRQLRKRVDENYPMLLEQASAIEILDEVQEEYHQSMSKIYNETLSLYNKIENRRKKIQEDVIIYENAMKLRRILNNGLLCKKLIDDVSKENNILAKAEIVCKLNAISSESPEMAKVKWMNEGFLYKMPEITRNVKGKVVAELMEGLDTINASTVTSCLKALDYLHCSKEELGKIYDETSKQIDALFLKVSINSGNNEKLSKLLPNLSTKLNTVLEQFELLGSEYIVTMSKKIATIIKNRITINAKNSMRIVQTLSKTISTHNECHVKAIKDALIPIKASILSQSLAILYGKIDEIFNEEDLQYESIAEKLIFEIKIEFSSVDWDHTLHKDVEANISKAVKYIAVKIENNLNMESDYLHLTGRVNKIQQKNYEMIHVAHLIAEEWRSIAQPLTQLVDQSLAAISLNIKELLSLVIASMHEEDMNKLLKNSSCSGYIREMRDHLKVFKTHVSELKELVENNTILSKFIDYVIENMLLNFTLIKPIKNSTYQRFAADLTSLCDKGLNPLNCKASLLLSDYQQIGEYLKSFGSDEKMNTINIPSSLPLWIHIHFLINKTENLKLPHLIKKMEYKEYVEWFLLLTDREKYDFLSSVVSTNSENCEHITKLLKQITTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAK9</accession>
    <name>A0A0N5BAK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAK9"/>
    <dbReference type="STRING" id="174720.A0A0N5BAK9"/>
    <dbReference type="WBParaSite" id="SPAL_0000307600.1">
        <property type="protein sequence ID" value="SPAL_0000307600.1"/>
        <property type="gene ID" value="SPAL_0000307600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000307600.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="47149" checksum="7CA2DAFA58DDAE08" modified="2015-12-09" version="1">MKLTNISEIHDLKSFNETKRVCLYQDSYISPWTTFASLGLLYILALTWYYKNRKSMCLPVPETIFPYTKRLKKLQKILEPYLVDDVFIELTDHKLGQGSIGFVFKGFVYPKTQTRFKQKKCAAVKLSYPIPQQSIGLLEEAARLSRLNHPNIVKLIAISRLSFSAFRPMFAMEWLSGGSLAEFFRNLRTSKNEDEKYGRKVYVRQIINVLSQVGEALKYIHESRDQDGSEFTHGDVAARNVLLTHRDLENCIAKLGDFGLPIDFGPRLPIPYLPPEIVCAADFLQCVHRVEADVYMFGVLGWECATLGGEPHYQKSFEEIQKSLSDRDRGLKRPKNCPDDYWEFILNCLDDQHRRPRFTGKNTANILTTLEKLSKHYINSTEHFTVVHNTSNCTCRQHRCGMPLPSFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBV2</accession>
    <name>A0A0N5BBV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBV2"/>
    <dbReference type="STRING" id="174720.A0A0N5BBV2"/>
    <dbReference type="WBParaSite" id="SPAL_0000350400.1">
        <property type="protein sequence ID" value="SPAL_0000350400.1"/>
        <property type="gene ID" value="SPAL_0000350400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000350400.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22028" checksum="0686305734D50ABD" modified="2015-12-09" version="1">MFIDPMLRSVHASTHPDNLIAGINIDSIPSDDKTDDQEYNLKYFENENNTREEDEYSKGCEDSKNNNEKSFICSICGKQFGCSSSLQRHNRLHKGSLCYKCAICSKTFTRTDTFNIHGMKHIQGHQGLECPLPNCSVKLDGVDAISDHIKRSHDNSIFNCKECGKVFTRSENLMIHYYNFHGPLKINRTLCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC04</accession>
    <name>A0A0N5BC04_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC04"/>
    <dbReference type="STRING" id="174720.A0A0N5BC04"/>
    <dbReference type="WBParaSite" id="SPAL_0000355400.1">
        <property type="protein sequence ID" value="SPAL_0000355400.1"/>
        <property type="gene ID" value="SPAL_0000355400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000355400.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44614" checksum="5097EB61D04221C7" modified="2015-12-09" version="1">MLSILKKRSFLISIVKSGNEIFSRGYINSSNRILIRSELSAYESATLLYSDKLRNLENNLALIEETRVETHKKIIKQMEPRIVKLKNCICNDKSDIVIGDPVGVGLVLPNDFVFNLVFVVSGDEIETFGSDFKLNSQFREGFIDTIINLIKADKSFWNDKEDTIKVKNRNKILLCFGDKTELRINFAANNELRNLNLFRYYAASDVRFRKLYLYVKMLSLNMKKLGGVKGLLDSHRIFILVGHFLQTSFGNQQAVLPVLTDIYSSFLSPNIPTKDVLENLYKPVDVSGIQPLINPKPLASHLVIQFIDYFANPDSYKSDIYLNKFHPVKEREMIQKSRPRILNFYTNKRLCSYDNNLYMFLRCMKNAQKLIKKGHFIDNFSNFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCB0</accession>
    <name>A0A0N5BCB0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BCB0"/>
    <dbReference type="WBParaSite" id="SPAL_0000365800.1">
        <property type="protein sequence ID" value="SPAL_0000365800.1"/>
        <property type="gene ID" value="SPAL_0000365800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="6">
        <location>
            <begin position="788"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="4">
        <location>
            <begin position="1780"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000365800.1"/>
        </source>
    </evidence>
    <sequence length="2309" mass="270762" checksum="D03CA839D0A3D557" modified="2015-12-09" version="1">MEDNFELSASEKTRQIKRMIRCRRRIRNKTLEATRIIKLCDFFNIAIPTNINNYELKRKYFEVNQFYNEHLSFLNIITDADCENFRRFIERVILYESNEDHILNNEIIPVVEGIEEHNINHELFDVENRNIDNLDIEIDEGHLEMINFVDDPNNQDVIGQSFENENRFSDIETISIDDEMLLNQNNSDENNIDPFGDGDINYDNIYEIDSDVYDDIYDEDINNIIENLENNPNIDNIENSSNRLNEFIPISHANLNIDYIVENTYGYSEELNRYIINNEISSMFIEQENAENDIINAENSTQSLNEQQYERSDNKRGKKEDEYKEKLESDFNEYNFLNYFNLKKDTELCAVQFIIDKSKDLAEEMRNYDIDVPKISRLPKILLNHDAERKRYSTVRSKTLDQSKFIGINICKNAPVPFTMDNTDMEEDPYGYLNRLFGGYRYHLYTKSQDIKEFELIYIIFAVVSRIFRSPSQYSYQISYYNDVLKKLLDVLPNEKRKEDIKQLISDVLSSNIGGQLSANNIINVMDDEIIMNDIRDGYEVPLHEMTSEQQQLIKYTTLARCCDERCKDINIVDHLEDIIAIFIAFQRPENNIKTIYKITKYIKDKEILTHLNRLGKCFSRIRGLVMRIKEIIYQLDWLVKVNRLIEYRDDPVLKNFKGFNPTLKAIVVEQMPMRSNEINIDQYRDVIQNVRDEISQIKLRMCIICERINISNMKKLKKDKKIYRRIMNIINTPDNSIDSSTIETAVDLYSKVDNNHPFLNKDEIYLCNDCYNGTIEKNLENNPLGITKYSIRNGLYCDKIPDIIASLNQFERLILQKRWIIQSVFAINNVNSNLRSKMHCISGYSISIKVNSQKSYNDLLTFGRRQIIIINKSQYKIRAHNLVDLKKVYNAYKWFIENNPLYKDDVLPTMEEFNDNFVEPQFVYVDDVSEKRKEIIDNLSREDKKNLNRRVKRRIENNEADPYDNELMFKLVGYITRTEFDSFLLESAYDGDENVDPIAVFTKEHLKIKWSDSELDMSKKMFEAFPHIFPYARFGSDFPRRIALTDKEFLKVLMSKAQRRFSKESQLIMALSKTEQKKDAVNCIRMIGNLKIGESMTIEESLAKSREGKLMRAFRKLKISDSYWYDVTRRLNVIETYIGSPTWFLTLNPSEHQWKELEEAYKLLHVDENISFNLKRSIEEDPFVLNLIFEKRLEIILEHLKSTESVLGRVIFYYYKIEYQQRGTPHVHMLLWTDEGMNLDYKDKGKVVEFLDKYITTSLYTSLDDPDFTEQIMKEQKHVCRLHYCRKRRLNKKAKNLNSNKIECYTSRCRFGFPKKPSHKTKILNLSEDIESLLEISRKTQKSYVLRRMENETEINQYNPHVKMMWIGNIDLQPNALNFSCSGAVNYASKYVSKSTLSNNEKVAEYLDTAMKSGNKNVSSKLFHLMYGMHLRPQAYTEVVDIARSAKSHYTSINVITVNTSDANNRTRHLYKDKRTENVKAATNMYDNYYFSRPPLLEDTCLFSFFANFTPRRVTSTCKLRYMDDFGYSMFLLSFDELDSNLKEKYFSGFSSDKYGNIYNYVTKNWTKRHISSPCFEFWREMSIPIGTTEGELANPQIHLVPHKISLIDFFQFMGITEEDDHEYFNQEAEKDIYARYCRLFLPRRREIDHNEEDCKKLFSDYMKEMKGKYRQTYNDINTLIKICNSFIKKNLASKEFSLYKKELYERYKEILDFDGRNFQRLQACNDGFTDPVAKFGDAQGLHRAVSKLNNQQYLIYEKLYDKSMERYESVKRGLDFVPTRILCDGPGGTGKSFLIDVLAASITATIRNKMDTLEYKNQPFILKVCPTGVASVNIKGRTIHSLFSLPVSKSRFKMKLRPLNTTAKSKLSEILRNVQLLIIDEISMVDASMLYSINYRINEALNCDGGTLFGNLNCLFTGDLLQLPPVKKTSKDAQMFYEEINSSMFEAQFKSIIGERSAFIDFNFIPLHENNRQKADPTYALALNEIRRGNITDDFISIINSRTFKNLNIVQLYFKAIGEGHSDPVILTTRNEDVNFINDQVVLEYAKRNDSTLYIIHCNDTAMDDKCHYKKVWLRKENRITEAPILDVTLDSLEELLIAYEKKSKRNESGLHEKINLCRGATVMITRNLDLDHSVCNGARGVVEDIVLNCDFDPEKKLKANNISEVKVRLYETNRIVSIPPSWHYFVCGKYLMRRLQLPITLAYCTTVHKSQGLTLSSTIVHFPVHEDNKISRTAGLLYVALSRVKHSSGLYIKDLDYESYNIPNEKSISVIQDWMSLNPNDLINYISYSNTTNNDVIDNNVNNVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCL8</accession>
    <name>A0A0N5BCL8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCL8"/>
    <dbReference type="WBParaSite" id="SPAL_0000376400.1">
        <property type="protein sequence ID" value="SPAL_0000376400.1"/>
        <property type="gene ID" value="SPAL_0000376400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024491">
        <property type="entry name" value="Se_SelK/SelG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10961">
        <property type="entry name" value="SelK_SelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000376400.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10032" checksum="CCDC4CB782BD0724" modified="2015-12-09" version="1">MVHMDKGGFNPIEIVKNFFVFIMLFFQSMFSPLLNLTNGSSQSSQSSFFRSGGASSGGGGGGSSGSGSGNTRRRNNIHGLPSVSDISSAPCASGGCCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCS5</accession>
    <name>A0A0N5BCS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCS5"/>
    <dbReference type="STRING" id="174720.A0A0N5BCS5"/>
    <dbReference type="WBParaSite" id="SPAL_0000382000.1">
        <property type="protein sequence ID" value="SPAL_0000382000.1"/>
        <property type="gene ID" value="SPAL_0000382000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF305">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="110"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382000.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50721" checksum="C436CEA8CEB26A23" modified="2015-12-09" version="1">MNLEPNSFIGEIKNEVVNLSPQPSFYPFVSSIQQSSPSNLITSPTQPPESFLTCRTSLQRFCNKRTSHFGRNRHPIVNNPFNHVDLTRYPVEVYNRLLTSCLQMTVGGQVQLWQFILELLGNSHLFSYCISWDGGHGEFKLHDPDEVARKWGERKGKPNMNYDKLSRALRYYYDKSIMAKVHGKRYCYKFNFPGLISACQCNPNFAGNMNPVTQAEAMLQRYTSGLPTNDIVLPSMTTNNLTQNLTSYHNPPSYQDLLSRSFISNTFSPNPLPSNEQLAGISATFPQYSPSFVGSSNTTNVLRDKDSIKAYWAPHPKGDQKRKGYLGNHSNRFNSSLTGEASNIAHNITHLNSFNHSYGMYPNSPPYINRPYQMVPSNPVLASPTQLSTQLPFDFRRQYMENIPFPMNVNITLQHRQSNSNQHLRHHQHLNSHHRHNLASNIHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCT4</accession>
    <name>A0A0N5BCT4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCT4"/>
    <dbReference type="STRING" id="174720.A0A0N5BCT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000382900.1">
        <property type="protein sequence ID" value="SPAL_0000382900.1"/>
        <property type="gene ID" value="SPAL_0000382900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382900.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47866" checksum="FF49FC8FA5B104A0" modified="2015-12-09" version="1">MTTFTASEISKNNTPRCLWIIYKGNVCDITDFYPSHPGGAALLKYAGKKSSLALQVLLNIAFTYSSIYFILMFIIFLYKAITLTYPVYIKVIEGLLIIEILPLEILKFSWARRGNLTETWAYLSLSMLLNILMGLICVYFMCCVLEYIILHFHQGKMSSEIVEDILQILDCKIGYCKYGSGPINILMIPGGVGCYKKDFPENVLNQFDPNLVTIVCIDPPGYGKSRPPDRKQSIQRCQLDAKYCLELMKVLKLEPFNAVGWSEGARTAIHVAGQGKDLVEHIVLIAASTKVDQRGAMVFKGMRNTNQWLPNAREVYLQHYSEDFIREQWAALCDLVSEVYEMLGGSFLAHNVLPQLQCPVLLMYGGQDRFVMDPKIISDRLKKCEVLFHAQANHDVHIKYPKWFAQNVYKFITKDEDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDC7</accession>
    <name>A0A0N5BDC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDC7"/>
    <dbReference type="STRING" id="174720.A0A0N5BDC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000401300.1">
        <property type="protein sequence ID" value="SPAL_0000401300.1"/>
        <property type="gene ID" value="SPAL_0000401300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000401300.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="64703" checksum="C9670F9807680F53" modified="2015-12-09" version="1">MLRQLLARTNDNVIQENQYFVENGFNNQAGQVPGVSGTTNINSNSGYLLPVPSSSFITGTDSYPLKDKHSLSSNDSIVGNLNILPNVPQAFIGTTNTGNHNYNYYNNNSATYNNYTTTTTPNHDSIALNGGQLSNNENGFYFDGNSGEFCQSYLFSNESNSNNGNSGNVGISDGDCNGINQNYFQRSIGIDNNNTLEINGHPKSVDDTNYRNSVTSISSINSITSISTKQLNKPLRKPSRSIRSSQAAFSEAFKKMALLRHINNRCDEEANYYSIDDTEIGPVRCVACLGEYPSKRSLTGHIGRNEKCREIIGRNYLDQLSQNGNKNILIADYSNDGISPVCPYCDRFISHYKGNIRRHINQCLKNDKKKRCRKSKENKEEYDNGTISTSINNNNNNNNNSYDSLNTPKSVECQNVTSSSKQTPSFDDPFMCNLCSFLTVYKGNMKRHLMACHNYNDIIFRTGTIDLEQLHASRQGKTISPSLLMRLTKKGKKCVQEGGEGNDKNLPQYSNTNGTFNNNIDNEYQIKNNNNKKRYEEKKSIQVSCNINGVTRKLSPGAEARIDTSVQTVIENGLSYYSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDE2</accession>
    <name>A0A0N5BDE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BDE2"/>
    <dbReference type="WBParaSite" id="SPAL_0000402800.1">
        <property type="protein sequence ID" value="SPAL_0000402800.1"/>
        <property type="gene ID" value="SPAL_0000402800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000031">
        <property type="entry name" value="PaTChed family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1288"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="615"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000402800.1"/>
        </source>
    </evidence>
    <sequence length="1367" mass="155600" checksum="A69A5B0978923492" modified="2015-12-09" version="1">MLTLIEAPTGKNTDGETAPENSRQGQRLLDYSQSNNINNEFEDDRDIGTTRLTRYIKSWRKFFVGKSNSGDYSQEWKREFSLHPTMSDADMTLQQIYLDNAQGSIPTLAIRSVIQNNVYMLASCVQKKPWLILTIVVSLFLMCTIGLQHVRFEDDIVKLWVPKGGHLNSEINFYSNLKKEFESRKNVWSQYEEEHFIKPFIDAKLENYKDEDENGGSYQVLIQTGEEDGQNLLTKNKLLEHVELMKQIKNISVNLYGLNWTLDDICFKPGDLSIKGDSMAKEYQPIIESLIPCIWITPIDCFFEGSKPMGPNPPIELNTITLLGYITQLPEENTLKWTNINPKQVIDDLSKVTNLGTMKEFFDRSEIGMGYLDRPCIDPLDPECPTTSPNYYNALPAFNIFKEALKEKNISIDSVLSKFVDSLDAFDFFFITINRKQSTNDTYYNSYRQSFMNYLRNNKIEAEELFNKTSYPEYPKYGDIVKNGCKGFARGVMSWSKNMIFGGINNTDNGEMTAEAMQTIILVSSPKEFYASFANNQTSRNKKLIQGNIVEEWNIDMAKEILKVWQRNFTQSIYNHELNFYSEPDYPDTKIERRRLHPLASTSIGDMLSEFCQFNYGVIFFGYGFMIVYAMYSQGKIRNYKLSHDSSVGLAFFGVLSVTLSSIAGLGVSTWLGIEFNAATTQIVPFLTLGIGVDNMFLLLHNYHTVTKSVKKNEVGVLLKETGMSILMTSTNNILSFLAGTVLPIPALRSFCFQSCILLTFNLIGIFTIFLAMISIDLRRLKDGRRDVFCCSYEGTYSDEEEDRGYGDGDNNTRVSIRNESIIERALSRSTAVSINNNNAYQSLNFIKGNDDDDINGCSDQLPAKGIIHRLLRKYYIPFLRYKAVKALILIFGLTLGVIGYLGTFSIKQGLELSDVLPEHTAPAAFLRARDRYFSFYPMSLVIRGENVDFATKQKLIENLRSDVGRLSYVVKNADGQPSEPFWMDLFKNWLMRLQEKIDKAASDGLLVDFDKRILNGSEEVKYPDLQVAYSLLCSYGDKEDCSRVGKVKLIENGIVNEEGFYNYLYGWHEYESMLYTVSQAKFYPPLYKLKEGTGNMTYRYFIPPVPRPRYSEIPFYMTGLSDTETIVQMIKEVRAICSRYTELGVDNFPSGIAFVFWDQYLNLNVTILKAIAIITFAVFIVITILLFNIWASACICFTLMIMTLELAGFLGYSGIKLNPVSAVSLITAVGIGVEFTVHVMYSYLTALGSRQKRMEMAIDRVFVPVIHGAISTLLGILMLGFSEFEFVVKYFFIIMSALIIIGLINGLIFMPVLLSLFGPNTEIKIKGNRKRLPPPPPLSRDIDLPNRRIKTRSSVTFPTTHENAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE65</accession>
    <name>A0A0N5BE65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE65"/>
    <dbReference type="WBParaSite" id="SPAL_0000429100.1">
        <property type="protein sequence ID" value="SPAL_0000429100.1"/>
        <property type="gene ID" value="SPAL_0000429100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF29">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000429100.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26131" checksum="6F9A7FAC1058D3F3" modified="2015-12-09" version="1">MTSNITVPDGWVISYEDPNLIKELLPYQYIDMGIGGGGIFINLVLLSILISSKYFLNNGRLTILLCIGDLINCLYICLQGYQRSLIYVKILNYNIIRPMTYWTCALMPFDWTGIIGSLLTHMVTLVMGLERIIALKFPVIFKRYFSNNQIVPTIFCLGYVVLSVIIAFILAFIKRNVLTKYYCGRKASYTAAYTSFIYIMNIVGYSVCFLLTIIVMLHIKLTSKESLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE78</accession>
    <name>A0A0N5BE78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE78"/>
    <dbReference type="WBParaSite" id="SPAL_0000430200.1">
        <property type="protein sequence ID" value="SPAL_0000430200.1"/>
        <property type="gene ID" value="SPAL_0000430200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894364" evidence="3">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000430200.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8084" checksum="BD735E143E0743B2" modified="2015-12-09" version="1">MKFSSRIVLFTMLVAIIMVCLVTHGNAEGNNGDEKDKQNNTSPDTPTAKAAAGLSYSGSNSIILSGLCALSIILGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE81</accession>
    <name>A0A0N5BE81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE81"/>
    <dbReference type="STRING" id="174720.A0A0N5BE81"/>
    <dbReference type="WBParaSite" id="SPAL_0000430500.1">
        <property type="protein sequence ID" value="SPAL_0000430500.1"/>
        <property type="gene ID" value="SPAL_0000430500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF29">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="55"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000430500.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="38107" checksum="35045CD5F1033DE0" modified="2015-12-09" version="1">MVLKNVTSESPSDVPSIINPINECKSEESFIPPAPVDNSRLNDDIKIEDNKILFDMKQINTHVNDIFSSSTSSLGNLGGYTTCLQRIIIGVKNLFNNMNYNHPDNVILTKQSDIRRFVKAWQRFIKYSPTLLMSLEEFVNFSLKDKWTIFRSFWRDAYTLISSVYLSKVKSPYNGALLLCDETYVIKLDDGEITDPNLDDKNSKEILNLMRPTLNLVHRYIHKPMKDDNYDEIEIAYIIVQMMFDRLTLDETSMECQKVGNEIIKLVNDELHNYYIYNKKMHNYAHRITEMTKLLSMVREYSTRHREIALISKWMDIIDMSLLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE89</accession>
    <name>A0A0N5BE89_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE89"/>
    <dbReference type="WBParaSite" id="SPAL_0000431200.1">
        <property type="protein sequence ID" value="SPAL_0000431200.1"/>
        <property type="gene ID" value="SPAL_0000431200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000431200.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="56201" checksum="B479A7EE06B044BC" modified="2015-12-09" version="1">MTSTILDAVVSSTASFDSITAFQEQFSLVMYFGFIIAFILAFAIGANDTANSFGTSVGSKALTLIQAYVLASIFETLGAALLGYQVTDTMRKGVVDVNVYDGSPGELILGQIGVLAGCGTWLLIATWLKSPVSTTHSIVGATLGFSLILRGTVGINWYQIGKIIASWFVSPVLSGFVSIALINILQLILQIWSKEYIGAVKILPALLVITVAVNCFAILYEGPTLFNINTLTSYQVCGISLAIGLACGAATYLFVKFYLNRQIKSILNGNVPRLDEEKINKDSSYFSCPLNEEFEKAANFMSKNSNSTKALLPNDKTSKDEVLLDVEVKGGKNHESNGQVILFETGYTQEQLEMICMNKVFGYLQILTACFGGFAHGGNDVSNAIAPIVSVFSIWNEADVQQTGGTPFSLLLFGALGMCVGLWLLGHRVIYTVGSNLTEITPIKGFAIEFGSAATVLFASKLGLPISSTQCKIGSIMFVGICDKTATFEWHTFKGIAISWLVTLPATALCSALITWILKSCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEK6</accession>
    <name>A0A0N5BEK6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BEK6"/>
    <dbReference type="WBParaSite" id="SPAL_0000443200.1">
        <property type="protein sequence ID" value="SPAL_0000443200.1"/>
        <property type="gene ID" value="SPAL_0000443200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000443200.1"/>
        </source>
    </evidence>
    <sequence length="1502" mass="172933" checksum="ED3F4853B15D617F" modified="2015-12-09" version="1">MSFFASSDEVNETHNSDLDKENNLPPRSQCFRRRTEDVNYDSFDDSPDNGIDDLSKLTQHANKKVLHTQSMVNKNDRNGSQLHGSTKKIPLPKELEDLFKNVGLEIVETDEYSACVSVVDGSVEYKNFISGLESHLKSLDADRIMPVLLSIITLENESKSFGILEVLSRPIRINENFFSSFLQILISMKVLQTRILQEIFKFFGRSTSEDTMVKTACDIYLDLLKDTGEIYEQEKICTIISSLKYDTFDIVYRNELAGFVYGFIQDFKLENELYRELMKWIKRSDLDDCENFRLALLESVKNVAADPVNIKSECFALIMNINIFECDSAIEVINYTSMALTSDNKNQIVLFLLALGQNLRFDKFKESPGFDKIICNMFCKIMMLITNYGANGINIVLSVLNGSGNNKTITSADFGVTSDVTEEELMDMDVNDEDGNDVDEEDKGEETVLKRRFSEFDYILSFATIFEYLNPPTNKVKDIAKLMVANIKNHRESLDEDREFISTLLKCGDFPIKYLEALMYVGEYFLKENNPDVNEMGKHIFLEMFSNLDYNREEIIALLVDNILSKDDVSYNALRTIHMIVKKCPYEFSSHIDYYLKRTSDQCTKFEPRLLRVFFKILSSLSISCSEEQVGTQISSLYEKFDQYLKSTDNNSFRVALSANIVRICELIRKDPEKYSSEISALLEKLDCCSSYLPEFRAYYFSEFSVNLKGGYKTFSKQSKELVEYMNKNVLNYVKDTYFMCLEKPPSYASSESDDFCPLFEGYNSLDARYWVKHTTFLKRDLSLGIWNVEMLNPLIPMIQFMYQVLRLLNKWKQQDDKASLENLYFIFEANIDLRGIGSMIKKENLNDREISDLRFGILFLLDYIGNLLNTFADCRCSPKHNEILQKKYRLYVKLEDVFYNIVNTNYKTCFKLPNLLSNGYSVSKNSLMLFGLKKSNLPVKVKKDLKTEVDHDKNIVDNEDNNMGNGNIGTLQVFGNTQTPNGKKDSKKSYFKILPFTKISEHTTPFTVSVLVKCVDAFLESPLLLNTVFNGLNVAISRIESSFVTKKTTNFGFLKNSKCPEIFFPYIDKQSKKDLRELLSNCVTPMMTVFNYCKEDVTDESENSPYQSFAEQSLKIILRSMKFSTNNNDRSGKAKIEDMIFQFISEKSASSVCDNDVAVTIFNYFLESRNCLITSSTMAVSVIEMLLDFIGENELLRLKLAKKCLDLLDYPWPEKNSANSSTVPYCKDTAKILEIYFNLLPPKYQILAAVYMVTKKLVYLAPIKDQKELMEMSFTYSFNYGKIAVSDPEELRPFNATTPKTLSYLYSVCFATLNGATQKYLAKNETLQNQSLEKQLNNWYFSVTCFSKLTDFICVQKFRTKSILSTVVKEGKKFLDFITSNKSSFMEHANNQEIFNQQKERFEQIFDGIERAHYNISSYNNEFQKKLTGATLKLFPQFTCGFTSFKRLFNNILKISAASASLSEKARKRSSNVEKNVEPKQKKRKSSKKAAPLEEIENMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEQ6</accession>
    <name>A0A0N5BEQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000447900.1">
        <property type="protein sequence ID" value="SPAL_0000447900.1"/>
        <property type="gene ID" value="SPAL_0000447900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894472" evidence="1">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000447900.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34840" checksum="C45BE30B9BEEF176" modified="2015-12-09" version="1">MFCFHSIFLLSVLGFNYLVSGITHQQAQEIVSKVITPLFAGFNHKLDDTSYSTNPSDLEKTGHVIDKITKIAIVPPDFELKLNGGKYNCAKMEVIKLCNLVPIYTYFDRHIKNTYIEDQAHLHQRRNDPHRAVSEVAKLAGYFSSKRGACGAVHDITRIRLSKKIEPILQKRVDVRIYLEPDTKPYRDQKRNNPKLYDSIFRKFGFGWKLNNVNTRAGLMRYNEVYNNQTVDGKPIDRSIYCARDSYGVITVEDYKDNLPLVGDEINLLKPKEKENVTSTPKVYKTCLSKILVTTTPPPDVFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF45</accession>
    <name>A0A0N5BF45_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF45"/>
    <dbReference type="STRING" id="174720.A0A0N5BF45"/>
    <dbReference type="WBParaSite" id="SPAL_0000461400.1">
        <property type="protein sequence ID" value="SPAL_0000461400.1"/>
        <property type="gene ID" value="SPAL_0000461400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000005">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000461400.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18782" checksum="039FF59583C35A7F" modified="2015-12-09" version="1">MMEFMLLFSRQSKLRLQKWYKPYPEKEKKKITRELIAQILARKPKMCAFLEYKHLKIVYKRYASLYFCCGIEQTDNELMCLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFMLDEFILAGEVQETSKKQVLQSINSQDMIQEEETPQGIFEENGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF99</accession>
    <name>A0A0N5BF99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF99"/>
    <dbReference type="WBParaSite" id="SPAL_0000466700.1">
        <property type="protein sequence ID" value="SPAL_0000466700.1"/>
        <property type="gene ID" value="SPAL_0000466700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF5">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000466700.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21930" checksum="536A8C577DFEEEEE" modified="2015-12-09" version="1">MSIFKKLRKSEKDSKAAKVPSPEPSLKQLDSRIGLASYRDFYSLKNYWKAIDRKRSDASFLFFSSYLKQSPENVKLYPKLKNVDISKITPDTADAGFETMAANYLKVFDDVITAVEETPADCSDACSRLIAVGKIHRAKVSGMSATQFQDMEKPFIETVSEILQDRFNEKVENLFRKFFQFCLKYLSEGLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFE3</accession>
    <name>A0A0N5BFE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LAMP family protein lmp-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFE3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFE3"/>
    <dbReference type="WBParaSite" id="SPAL_0000470900.1">
        <property type="protein sequence ID" value="SPAL_0000470900.1"/>
        <property type="gene ID" value="SPAL_0000470900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894192" evidence="9">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="10">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000470900.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26256" checksum="D10FDAB13EF7B81C" modified="2015-12-09" version="1">MKDFILLFALAAVISADVYTAKTKEGTYCIILEANITGSITYNKKGSTTTLETYNFVVPHGATSSGSCVSANGTQVLNIDFLPEANITGTWHISLSFDTKSDFEKEKSFKLISYSLHANLSDDSIFNSTQPYKKYKSSDKFSDWDVAGKNTAYTCSTNKLEFDEGAKLIFDNLKVIAEEELKKPYFANGTIYNVCFEDSKTSDVVPIVVGACLTGLVIVVLVAYLIGRQRAKRQGYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFH1</accession>
    <name>A0A0N5BFH1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFH1"/>
    <dbReference type="STRING" id="174720.A0A0N5BFH1"/>
    <dbReference type="WBParaSite" id="SPAL_0000473700.1">
        <property type="protein sequence ID" value="SPAL_0000473700.1"/>
        <property type="gene ID" value="SPAL_0000473700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="12">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000473700.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="26365" checksum="500DEAB06CDFE282" modified="2015-12-09" version="1">MSGKFKLADDSQLRSLKDRVQCIKELVPEVQLPTKVDIIKHKLERNSKSTAIMCKLTAPKSTRIFTPDDCPNYNDEMKNENIVLVFPSKDAIPIKEYIDKNGPIDRFVFLDSTWQQTGSLRNIRKLCKLPYVSMKTYRTDYWRPQYKFGDEYLATIEAVYFASKEAWEANNPEKIYDGFFDNLLFWFYFFRSFVREDYYPENRKLLEVHKKRKREIAKCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFJ1</accession>
    <name>A0A0N5BFJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BFJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000475700.1">
        <property type="protein sequence ID" value="SPAL_0000475700.1"/>
        <property type="gene ID" value="SPAL_0000475700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="258"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000475700.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45830" checksum="2C93292DCA033529" modified="2015-12-09" version="1">MSEEEKISKNQLNPDDYEIVALDDIEKGDVDLAEVLKRNGHFDDHDENIEEADCEYIEDEESDTVVDEAIAHLVGHEKDVFSIDLLDGRYLVCGSEDDSASIWDLTKDLKKAAFVISSHKDSVTQVKFSASKRLLATADMSGTIIITDLQYQSTRCTLEELIDLEWIVWHPTADILFAGGGEGVVWMWLISKSGVAQSKCYLARGSTCTIGKLLPDGKKLLAGYEDGTARIWNLKDSTYIEMVFEEPITTCDVHSTSPLAAVGTEKGKVFLFNTESGKTLKILNFLKGDKQENEEENSIEDVKFHPIQTWLAVGVNNGQISLYDCTSGVPRFEFKGDEAPIVKTAWFTLSSGTVVLVAANIDGVIRIWEGKSGDLYKSISGGGAEIYDFVVDGDERSVKLFTACAEGVVRVFECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG81</accession>
    <name>A0A0N5BG81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG81"/>
    <dbReference type="STRING" id="174720.A0A0N5BG81"/>
    <dbReference type="WBParaSite" id="SPAL_0000498900.1">
        <property type="protein sequence ID" value="SPAL_0000498900.1"/>
        <property type="gene ID" value="SPAL_0000498900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="603"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000498900.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="89502" checksum="21897B91F240D765" modified="2015-12-09" version="1">MHGFRTANSPPLTAEEMREILDTRTPLRTDYNLAKSVVYDKNGQFGYQISNLARQRLGQETIVEGTWKSYFHTRYFPLPRKVKKYFGILFQFFFQLLSVTYYFFERHIYQILLFFFDMNDPLSASYSDDNYHNCEIKSSVLRTRPVKVQNIFSRVTRVNRTPSKTTVVWRFFRDSISKFFSSIIGCTYNVISVISSKGKAVTSSFLNNNMEKEGTETSRTTVRRTSGAGKKFGFCYFCLIPLFIVLLAALLFFLLNGHDNENIAKKIDLSNKVIGDFVSQAIKSADSIKSRGVNFAGDVYHKGIDYTSDVYSKLSEDSGVIVEKSNAYFYGAFYGFVRFLSTLREFIDSMLAYVFQLIHDILSYIFYSLYLLYSTLISVVAGMVTRSRESTVTIEPKVVEKPIISITKKDGNVAVPFDEEAFTKRLLARIQVEIENAVANINFKEKEVKVIEKHIEKESPVSVENIMNEINIALAKELSNIKTMLDQKLKTVQDKMEEQQRASMSAFKHSVDGVTKEVRYKADNNYVDRILSDSFAAFKMEIQNILKEKLEEFSTTNRYTKDLSTSFSNDKYMSDVNVLIMNLLEKYDHDKTGLADYALESSGGSILGTRCTQTYNERSRVESLWGIPLWYVSYSPRTVIQRKSQGTIPGECWCFKGEKGYLTISLSRPIHVTNISYEHVSVDLIPTKEVNSAPKDIQFWSFNDVNDHDTKVNLGRFVYDTSKKPLQFFNIPLTYSNLVTPIVEMEVLSNYGAEFTCLYRLRVHGNLPTDSDHSPDNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGY4</accession>
    <name>A0A0N5BGY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGY4"/>
    <dbReference type="STRING" id="174720.A0A0N5BGY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000523500.1">
        <property type="protein sequence ID" value="SPAL_0000523500.1"/>
        <property type="gene ID" value="SPAL_0000523500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000523500.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37210" checksum="8F4EF5530E665A22" modified="2015-12-09" version="1">MGSYIKLISLIVLIIQTTLLVLTLRYSRTQKITGSRYLSSTAVVSSEVLKFIISSIILWTTNDFSFKKWYAEIRRDILQKPLDNIKVGVPALLYVIQNNLLFLALSKLDAATYQVTYQLKILTTAFFSIGLLGKKLDKFKWISLILLTVGVALVQLPSDGGKKNVEVNEGNGNFSDKFIGLIAVVLACFSSGFAGVYFEKILKTSNVTLWIRNFQLSFFSIFGGYIMVWLYDYDAVKENGFFQGYNYLIWFVVFLQAYGGLVIALVVKYADNIIKGFAVSLSIVLSSFISWIVFDDFSPSLTFGIGATIVIGSTFLYGYEFKSKMVGVKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHY1</accession>
    <name>A0A0N5BHY1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHY1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000556600.1">
        <property type="protein sequence ID" value="SPAL_0000556600.1"/>
        <property type="gene ID" value="SPAL_0000556600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000556600.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10925" checksum="07FBA501A64D3155" modified="2015-12-09" version="1">MVCEKCTSKLRQLPSAKKLPNSKRPPTASSSSISRPLQSKDKFKPNSKETFRKCNICKKPTHREGAYYCQDCSYQKGICALCGRKIANTSSYRQSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIK2</accession>
    <name>A0A0N5BIK2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIK2"/>
    <dbReference type="WBParaSite" id="SPAL_0000578375.1">
        <property type="protein sequence ID" value="SPAL_0000578375.1"/>
        <property type="gene ID" value="SPAL_0000578375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000578375.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8617" checksum="DF220D084E832F88" modified="2015-12-09" version="1">MDDKKFEELVRLKQENIKKLENISKKLDNIDFSTDETRKQGEYLKSLGISIEQCIKNSVINTSDPTDPPVYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIR4</accession>
    <name>A0A0N5BIR4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIR4"/>
    <dbReference type="STRING" id="174720.A0A0N5BIR4"/>
    <dbReference type="WBParaSite" id="SPAL_0000584400.1">
        <property type="protein sequence ID" value="SPAL_0000584400.1"/>
        <property type="gene ID" value="SPAL_0000584400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF34">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000584400.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24121" checksum="8B04B578751C1CC9" modified="2015-12-09" version="1">MSSEVESNNTNNMATASISTTQPSVTKTPSTQVSATQPSAAKPSPNDNSTVSVSFNKLHGMMVKEMYKDQNKLLTLVFKKYEEATGQKRETLIYGTCGIIALYLCFGYAAQVLCNMIGYAYPCYKSIQAIKTEEKEDDTKWLMYWCVFGWFTCVDFFADNIFGWFPIYYLFKAVFLLYLALPWTNGSVLMYKRYVEPLSDKIEAYFEKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ14</accession>
    <name>A0A0N5BJ14_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ14"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ14"/>
    <dbReference type="WBParaSite" id="SPAL_0000594200.1">
        <property type="protein sequence ID" value="SPAL_0000594200.1"/>
        <property type="gene ID" value="SPAL_0000594200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894599" evidence="1">
        <location>
            <begin position="20"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000594200.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="81377" checksum="9B93140EDF0CDADC" modified="2015-12-09" version="1">MLILCHAILLNLIYLQLYAQDLTNNSHAITSSDVKLTIENLKRNASISVCQIKKYPINKNSPELRLPQNNPTCYKTYINNFIIIKNGYIRYKFFNPTVTCKYQCNYPDGESEITVGKWRNINRGKPNCDVFEVQCTTTFWPHVLLFQDLYFQVAKKKIEKPKKVTFLKDPYNIANINNKYNVHLIVIDSVSHYMAMRGLENTIAYLEKEYSAALFKMNNKIGSNSRPNAHGFLLNRRISSLRNFLNIEKVKPSDYITIGKNDCNEYLDDQPFIINYYRQLNYTVLSGEDSSYTAFTSNNCKGFKKHFAHHTTRPYALKLFNPKYSQSNKFLRIHESKCLGYSNYQFDYLINFMKTYKDLKQFTFTWITHIAHDKLTGHYQYDNYFKSFFKTNKYLFDNGFLIFMADHGFRTGKYRSSEIGAFEDKNPFLIISPPKELRTNSSEVLKNLKINANKHTSHFDIYATMLDILTEGSRTNFSNMSYFNFTNIVKNDTIKGSSLLRELNENRTCYSMEITSEYCLCREKFTNYDGRLLQFNESSTSTTRNDDPLVKNIKKLFVNVLNDKLNKTGLTEYCEMLSENENGEFKLQYLYNEEKKIIFYIKQEVLPKGIFEAYLNEDGKIISDSIERLDRYAKYAEVCVPNHADRMFCYCKNLISKELKDPPTKKKGDMNRIFNKPLEDMKNFIKKVFKINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJG1</accession>
    <name>A0A0N5BJG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FeS_assembly_P domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJG1"/>
    <dbReference type="STRING" id="174720.A0A0N5BJG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000608700.1">
        <property type="protein sequence ID" value="SPAL_0000608700.1"/>
        <property type="gene ID" value="SPAL_0000608700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000608700.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18357" checksum="C20AF0DB54178629" modified="2015-12-09" version="1">MVKDGLDNVAPKVYDVKERGYSKILQKLALSDDEPITAEEVFEYIRDINDPEHPYTLEQLNVVQEELITVNNDEENPFVDVRFTPTIPHCSMATLIGLCIRIKLERSLPPGMKIITRITQGTHNSEESINKQLADKERVAAAVENQNLMNTVNQCLKTRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKH5</accession>
    <name>A0A0N5BKH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKH5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKH5"/>
    <dbReference type="ESTHER" id="strea-a0a0n5bkh5">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000643200.1">
        <property type="protein sequence ID" value="SPAL_0000643200.1"/>
        <property type="gene ID" value="SPAL_0000643200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894728" evidence="5">
        <location>
            <begin position="18"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000643200.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65176" checksum="840862865BC60DBF" modified="2015-12-09" version="1">MRKLLIIINLSIVLCYAQNPVNTSYGSIIGKKHKLFPDVTEYLGIPFAKPPVGKLRFKVPMELDKPAWNGTFNASTVANTCYYVNNNQFLVGYPGYDFWHPNYLNYSEDCLQLNMWVPKNSTGSALVFLFGRGYHTGSPSLNVYDGSFLALKTGAIIINLNYRLGVLGFAYMVNSSNLPGNVGLLDQQMGLKWIHENIVNFGGNPKNVTLFGEDVGAFSGTAHLFSSGSHNYFNKLIINSGSVQNSWFRESNKIANDNLLALAKSFNCSGNDNETFICLQSQDVVKLITEANKIKNNDQSPLISPFIFVEEDDNFFKGNLSMKMLKNDMMKDIDIMIGITSDEGSYLMVQYLNDETFGCNFNKNMSYDSEDNICPMTEEQFENVLKLTSVYDKYSVEDFLDLNETYDKIDLKVPRYKTLKFLSDYMFNCDISLFAYMFGLQVKGKKYFYEFQKKSKINHWPEWMGSMHTYELLYQFGYPFTHPESYSKDVLKEEQDFSMKMINIVSNFIHTGVPSLKWQEFNETTIKAVVLDGFYNDNGQIKYSNPYSQGCYTIHSIKSRCQELNDWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL81</accession>
    <name>A0A0N5BL81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL81"/>
    <dbReference type="STRING" id="174720.A0A0N5BL81"/>
    <dbReference type="WBParaSite" id="SPAL_0000668200.1">
        <property type="protein sequence ID" value="SPAL_0000668200.1"/>
        <property type="gene ID" value="SPAL_0000668200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000668200.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="31629" checksum="AEFCB241BCA2475F" modified="2015-12-09" version="1">MVILVYNTTADNSINHILHPHQIAIVHQITIVMVVKSASEYNYEQAIETVKCYSWHYNYNFVILRQEKVSEFSYNCHYRDFMFRRHCIVANFAQKYKNEIKYIVFIDGDIGVVNPVHILENYLPKDGEDILFYDRTFNYEIMAGSYIIRNTLYTRSFLKYFADYEYKMPTTNNIRDNVVLQAVFVDFMGTVEHRKKYLQCMKIYNYAKGYEENMLFVSCMRYVLNLMNETPNDTNYHTYEGGKIKILRKLSKKRWKAYWMEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLP9</accession>
    <name>A0A0N5BLP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000684500.1">
        <property type="protein sequence ID" value="SPAL_0000684500.1"/>
        <property type="gene ID" value="SPAL_0000684500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000684500.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29812" checksum="BA97C7A86A2781BE" modified="2015-12-09" version="1">MMPYIDARYVSVEIDVTSSTRLHQKVYYCKGHNFYSFEEVLTYSLKYRCHISFQTTIQLVTRKPDVIKPTPAPKTFYVHTPFGPVYYRRNFPTYHIWKETWLNCGTKCCTFHKSYKFSELKKKYYTEINRYRRFVYLSPLIVHPKLTRLAQNRASYMAQHFVLQSDENQRYDEVIGKVRSTILINFIRILFNDAWFHNPYFSRISATRRDFARIMSQNQKFIGVGMAERFGHVFICIKFTPKSWSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLT6</accession>
    <name>A0A0N5BLT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type proton ATPase subunit G</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLT6"/>
    <dbReference type="WBParaSite" id="SPAL_0000688200.1">
        <property type="protein sequence ID" value="SPAL_0000688200.1"/>
        <property type="gene ID" value="SPAL_0000688200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000688200.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23693" checksum="55CFD9E778F36E16" modified="2015-12-09" version="1">MITIHFFTILCTFTYSLFIPYASPYWFEHSGCSSLYYFNFCSFCYSIDNVMYFLSYVPYSERCEFIRIGNQRDVAKGEISKQEDEFMKRQSEYAQKRYEDYKKNQLENEKEEKSRLDLRAQRLSQEAKSLYDNVYSVLNNTEVTIRQEYQLVHTIINEAKFKAVVEASEFIPAKYFANTFGGLFVFHIHDNPFDCYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMA3</accession>
    <name>A0A0N5BMA3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMA3"/>
    <dbReference type="STRING" id="174720.A0A0N5BMA3"/>
    <dbReference type="WBParaSite" id="SPAL_0000704300.1">
        <property type="protein sequence ID" value="SPAL_0000704300.1"/>
        <property type="gene ID" value="SPAL_0000704300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="97"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000704300.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31401" checksum="0DF0B4AE967B36B6" modified="2015-12-09" version="1">MVRDRVNSEGSGGSDKDVSSRRSASRSPRRSISRSPDARSNSGSPKRNGHSPDKNRSESRSPRRRSRSKSRSRSATKSPPRKSGRGYKEREPAEPSRCIGVFGMSTRTKDEDLESVFSKFGAIEKVTIVKDSPTGCSRGYGFIYFKDIEDAIKAKNEMNGQEIDGRNVRVDYSVTKGPHDPTPGVYKGNKPSRRDYRDRRYSPRRYGSRRSRSPRYSDRRDRYDRDYRRDDYDRYDRRDDRRGRHDDDRRHRRSPRYDRDRRGSPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNK5</accession>
    <name>A0A0N5BNK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase subunit epsilon, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000748300.1">
        <property type="protein sequence ID" value="SPAL_0000748300.1"/>
        <property type="gene ID" value="SPAL_0000748300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000748300.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7742" checksum="F1F03D0998B0E148" modified="2015-12-09" version="1">MGTFTLAYAVKKIIVDQKSAWLAAGVVLYLGKCWENAGSHKTEMMKGHSRMYADRTAAIPRHIDPWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP74</accession>
    <name>A0A0N5BP74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP74"/>
    <dbReference type="STRING" id="174720.A0A0N5BP74"/>
    <dbReference type="WBParaSite" id="SPAL_0000770100.1">
        <property type="protein sequence ID" value="SPAL_0000770100.1"/>
        <property type="gene ID" value="SPAL_0000770100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000770100.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17991" checksum="511F831B9B9B9EDE" modified="2015-12-09" version="1">MADRWMRPFSRDPFFISPFNEARRFFDDFDRAIMNSHFWSNKSFIETHKFGESCPEIINNDKEFKIKMDVSHFSPDELKVTVKDKCLQIEGKHEEKNDKYGSIQRMFVRKYALPEGLVEDNVTSELSKDGILTVGGSKLAIEGDKTKNIPIEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP89</accession>
    <name>A0A0N5BP89_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-1,4-mannosyltransferase bre-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Bacillus thuringiensis toxin-resistant protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP89"/>
    <dbReference type="STRING" id="174720.A0A0N5BP89"/>
    <dbReference type="WBParaSite" id="SPAL_0000771600.1">
        <property type="protein sequence ID" value="SPAL_0000771600.1"/>
        <property type="gene ID" value="SPAL_0000771600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000175">
        <property type="entry name" value="Beta-1,4-mannosyltransferase bre-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0978">Insecticide resistance</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="187"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00084120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000771600.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52842" checksum="ED111CA27463CD1A" modified="2015-12-09" version="1">MAFTAKTKHYLHVFCLTIWLIGFQYISNLISSMNAANVNLINPVETYGLVITSLLYMIKFLSLLVLPQVIFNIAGMLMYNGFKETVKLQSAPLLAPFVCFRVVTRGMYPDLVKDNVVKNMKTCMDAGLENFMFEVVTDNAIHLPTLIRAREIVVPSSYRTKSGAKYKSRALQYCLEEDINILQDENYIVHLDEETLLTENAVRGIVNFMVDGKHDFGQGIITYASGEIVNWITTLCDCYRVADDMAKLRFQLSYLHAPIFGWKGSYVVTKVGSEKKVTFDHGIEGSIAEDCFFSMVAMRDGYTFDYIEGEMNEKSPFNFWDLLQQRKRWLQGIYLTVHSSLIPWKTKLFLAMSLYAWITMPITSLNLLLCPMAPVPTFFLFDFLVTLIGSVNLYLYVYGAVKSFSHKYRGSYFKIFLYIASAITVLPLNIVIENMASLMGTLASKDEFYVVKKDIIKLQESMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPE8</accession>
    <name>A0A0N5BPE8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">dTCF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Binds to the beta-catenin homolog arm or to gro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPE8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPE8"/>
    <dbReference type="WBParaSite" id="SPAL_0000777400.1">
        <property type="protein sequence ID" value="SPAL_0000777400.1"/>
        <property type="gene ID" value="SPAL_0000777400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007500">
        <property type="term" value="P:mesodermal cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="190"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="190"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000777400.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49617" checksum="4907A0A708249866" modified="2015-12-09" version="1">MSSADDGADEVKVFRRSDADDVDGGQSSAQLTEDKKDVALETELESRSTSNPIDMMAGARKGFQWNPALNPFQSPMSPSCMPFMMPNLGAGFLMSPNYNPYLIQQALSPSVNMFRNMAAMSQGSPFYQNPLVAKQYAANMMRSMEGQMNPLNMRFQPNNMMPSSSNESGYGNTPKRMKTEEEKKPPKEHVKKPLNAFMWYMKENRPKLLEEAEYKEKQSAELNKELGRRWHDLPKEEQQKYYDLAKQDREDHQQKYPNWTARDNYAIRKRKKAKREKSMDGAENKKCRARFGIQNQESWCKHCKRKKRCLWYREKGEGAAPSPALSSSNGMSSSRTPVLSSPASSGVMGSIDENDHGNQSDNEVDLNRTTVLQDLNQTPTSANFVKTENLPMPPNPMALNPHMNMNMTMMNPMMLASPNFMNPWMAARMIPDNQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPU3</accession>
    <name>A0A0N5BPU3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000791700.1">
        <property type="protein sequence ID" value="SPAL_0000791700.1"/>
        <property type="gene ID" value="SPAL_0000791700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894943" evidence="1">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000791700.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19835" checksum="78F0673645AA86FE" modified="2015-12-09" version="1">MHFIKYLTIFVLLAVQYSFQDTSSSESSLSSSEENELEFAKSQEMPLPNDVTLVNDVKPKKSLVKKLKDNIKKQKESVKSALKSKLDKANIKKGLEKTKEKVSDTFEKGTKTLEKAFGKMKKGLNTLLKKKNSGKFDSSENDIRKKRSIVGKVINGFKNVASKGTKKVKEALRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPX7</accession>
    <name>A0A0N5BPX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPX7"/>
    <dbReference type="WBParaSite" id="SPAL_0000795300.1">
        <property type="protein sequence ID" value="SPAL_0000795300.1"/>
        <property type="gene ID" value="SPAL_0000795300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894672" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000795300.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13000" checksum="B7322DA037C038A9" modified="2015-12-09" version="1">MYYKFHILFMSTLFLFGLEKKYVSAIQCYSGSQLQMIECPSMSCIKQTLGLDTVRYCDGTGVSSICQTYQIFDSCSNIPNLGYICCCSSGLCNSSNVNKGNIFMSLIPLLIGLIFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ47</accession>
    <name>A0A0N5BQ47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ47"/>
    <dbReference type="WBParaSite" id="SPAL_0000801800.1">
        <property type="protein sequence ID" value="SPAL_0000801800.1"/>
        <property type="gene ID" value="SPAL_0000801800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894689" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000801800.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19933" checksum="0BAD33855496C7E8" modified="2015-12-09" version="1">MKIIYTLIFLFFQILLCVFSIPYLPQTYPSEQNDNKKSFRTANQVIYLGPNINTNDREIILNAFKQIERRTCFRFNVLEFKKLPRHGMPNNHKSYGVIMKSNRFYGYIDREISKYQLKSTIYLSNRGLHHSNKNTARGIIMDQILKYMGLKEEYLRPDAPSYVKEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR00</accession>
    <name>A0A0N5BR00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR00"/>
    <dbReference type="STRING" id="174720.A0A0N5BR00"/>
    <dbReference type="WBParaSite" id="SPAL_0000830600.1">
        <property type="protein sequence ID" value="SPAL_0000830600.1"/>
        <property type="gene ID" value="SPAL_0000830600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="263"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000830600.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="44180" checksum="3DA275C76A4CB796" modified="2015-12-09" version="1">MLSHYHCEDRTSNGLESFHRKLNSRSVVGKHRKYEFFVEALKLLHFEEVIDFERHYSRELNEFTFLPTRRRYLERNRKIKALTNSFDVDGDNLLMVQKCAKLLAPRNVQQIFKSSGKIYTVEFDDSSDDSSDDLSNSDNFFDDTIIDVHLNAAFYMKEEVPKTRKRSCSSSSEKIVIKKRIDRNICNNVDKTVYPHDFLTSTKYYLDDQQVENDICLICGLKNISNFSIPLAAVSLEILKENPSISDSLVRGMFNPGKGNLFIMPLVYNNHWILFIVDTKKHEIYFYDSFDLYSNLISIFQKNFSNVIGIDINNYMITMIQGLKQDKNDFTNCGCYVVIEFYKFILHKETPKQLTPTQLWNLRVSWNDLLTELEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRB4</accession>
    <name>A0A0N5BRB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRB4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRB4"/>
    <dbReference type="WBParaSite" id="SPAL_0000841600.1">
        <property type="protein sequence ID" value="SPAL_0000841600.1"/>
        <property type="gene ID" value="SPAL_0000841600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000379">
        <property type="entry name" value="Hex homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000841600.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29619" checksum="A43E2B0C1BB6BB77" modified="2015-12-09" version="1">MASSTDKSFPIGFSICNLLNPSLKQDDVIQDPKDKVGNGNLKTESPDCSQQSTSSSTPESSFDPLQSMTAGLQLPLINNMSNNHPMLMLAAATANNNNQNPLLSMNGNNNNPYGGFPNPNWQNAVNYVTMAMQAHQQIGSGGLPMVNSWDPRFPWLNPFMNKSSQKRKGGQIRFTNEQTDALEHKFDNHKYLSPQERKKLAKSLSLSERQVKTWFQNRRAKWRRIRKDGEDDDELINGISAGRNMVKYDVNGHTGYHQNYGNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRD5</accession>
    <name>A0A0N5BRD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000843600.1">
        <property type="protein sequence ID" value="SPAL_0000843600.1"/>
        <property type="gene ID" value="SPAL_0000843600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000843600.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18657" checksum="D9886F1C0E8614C4" modified="2015-12-09" version="1">MPKEVKRKRTHTESNDGESNDDRENQICEVINSNSNNSSNPAEFTTNNPRKYGTSNFDKHLRNVHKLSIVQSKDKGGGKKDFDKKSIALNFIKINPCYRIFSNKWFKFFNDSLPSASTVQRYVKNLANEPYAKLQDGLEDYKFVLSFDGYKFQQRKMLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRQ7</accession>
    <name>A0A0N5BRQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000855200.1">
        <property type="protein sequence ID" value="SPAL_0000855200.1"/>
        <property type="gene ID" value="SPAL_0000855200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000855200.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14277" checksum="C3AE2E7BD7DE74D7" modified="2015-12-09" version="1">MMLYFCNICSSIFADYTIFFIHTDFCISFLYEQYNRSIAGLPCNLNPKVIAPDNLQKIVKQVFAPEPYLVVEDEKVHITQPLYIETDFDTLKGFNKEENVSTTSTTCDSINYEPLLMIKPSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRU6</accession>
    <name>A0A0N5BRU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRU6"/>
    <dbReference type="WBParaSite" id="SPAL_0000859100.1">
        <property type="protein sequence ID" value="SPAL_0000859100.1"/>
        <property type="gene ID" value="SPAL_0000859100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF93">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="648"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000859100.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="79238" checksum="F3E0C967084D0B50" modified="2015-12-09" version="1">MILFIDWLSRLFGFLESSQFQKAKPITLHISLLFLVFIYAFVGGLVFLKLESEATEIKRREELTEKTKCLEDIFYSSLNKTAAKSNETISLILACFLVETDARSQWTFVTATLYGFGIVTTLGYNRIAPVTTSARLFCVVYGICGIPITMIIIANIGQYMNQFAKILRKKLQNWIIRRRAKRRKSVKSKGVNYGIIGKEDINGNIDHENGELDGLSNENDSESSDSDDESSSAGVTAFALLIIFLLYVFFGALLLPGLNGRIDFLNGIYYNFLCLTAIDFGQLVPQNVHLLPITFLYVCIGLAITTIAIDVGSEYMKQLHYLGRKMKNVATTKIWFGGKQMKVKELLVAVTKKCGVDPNVIAHMNLENVVERVIAINEGREPPPDLNEHIFCDGRIRKSFDDMSIPHMDDEVDDDNYYNDNSLVITKDDLPPPPMPPMSYEELPLLPSGSSGYCLMKQSSIKSDWSLKFNKIAPIQPTTPSCGDDSSLHDFEDQNKKFFEFPARRVPSGINFNYIQAPEETLFDLPPMLLSKGSESLVPIDNDFNIETFDLNDTNDKLIILQDSNNTIQKDDEIPSKKTSPTVTTIVTHDDKEPKRFREKKEKYARDANKLFQTYQEEWNRIEQLTVNKLGPRRKSVFDVHNIDKSVHITTPRSMSPSHTSTQLNKKHNNSSSDNHLKLRTHSPKRPSSAQNLGDKERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS96</accession>
    <name>A0A0N5BS96_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS96"/>
    <dbReference type="STRING" id="174720.A0A0N5BS96"/>
    <dbReference type="WBParaSite" id="SPAL_0000874000.1">
        <property type="protein sequence ID" value="SPAL_0000874000.1"/>
        <property type="gene ID" value="SPAL_0000874000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000222">
        <property type="entry name" value="SyNapTotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000209">
        <property type="entry name" value="Synaptotagmin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF360">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="344"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="474"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000874000.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="77966" checksum="C91C9755B79BA256" modified="2015-12-09" version="1">MVSFFHFTSLSRSHMLNNTFVQSNETTQLILTKNNSFKYSKELTSPNLYFYSLIFGIIFVCSILFCVVLCIIKWLPGCLIRIIGLRTERVANSVRKSFRVKGSIFHNTKTKRKIFKRSEYPGEDRKYYKKSIEHGTISEEEVFIPVDNHEKRGTEVNIGTSNDLLKCSSKKLEIKDKTSTYKKCSSENGKTKLIRDLFTMTSHNEIMPPWMEHRITTDQCVAAAAAAFLGGQNGGVSGKTLTTPKMNPLGISLLRTASDKTQSSFGSSFWHKITHRDKTSNTISNNDILDIHRSNTTTDIADSPSSVIFFDNGIDDKKNKEIEYEYKSVFNYQVPTEKINNECLRGTLTFLLRYDFIHRVLMVHVMRANGLLIGDRSILDPYIKMYLLPERRHHCKTRIIKKSVDPEYNEMFSFDVQYNNLSSRMLQFTVYSFDRFTRHGLIGNVIMRDLFEKSDLYSWTEYTLPIVGSQEKNDFGDLLLYITYSISEQKLFVTVAKAYNLRPMDITGASDPYVKIDQIYHGKRIKQKKSSIKRANLNPVYNENLEFDLPLHEVRDTNLLVQVMDWDRIGRDDLLGCCILGKDSPTKEGFNQWSDCFSFLDATRFKSFNTNIASGNIVIHDASIATNGLIPPTNASGPNLSASLNTNGYFSTKSIGTWHSLLDDIPENYKDIPKAKKNSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT52</accession>
    <name>A0A0N5BT52_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT52"/>
    <dbReference type="STRING" id="174720.A0A0N5BT52"/>
    <dbReference type="WBParaSite" id="SPAL_0000904300.1">
        <property type="protein sequence ID" value="SPAL_0000904300.1"/>
        <property type="gene ID" value="SPAL_0000904300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894816" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="28"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="750"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000904300.1"/>
        </source>
    </evidence>
    <sequence length="956" mass="109111" checksum="264F8AB101607FD2" modified="2015-12-09" version="1">MNSSNKYLPFILLITFISISSASDAALKTEWTQKYIGCPNGMLFENFNRKNENLNDLILVTSDNNTLSTLSMNYGTINWRHLFEDSSNELRIASTNKAVFTIFPDGIVRGFKKLTGEMFYEELLASNTVENYNIFIVDNYNVAAIFDNIVYLINTKEKSHNKYNIPKDVKTSVVSIGVLDSESSYHIVFSSADTISLINIKKDDLETQTITKLDKMVVNHRTCAVSGKYLLCQTKDNTQLVYYDGKDVKTLGVDGKLVNKISGVTNNGIFLISGEGFSKIYDLNINDSPVIEKSSPNCYVMSTTDKGYLACLEENNKFVLYNANKLTKPVFSKTLEVDMKNNYSGIKDIFFTVREIDGDISVFVAMVANDCQIDFYETAGEESFTHEWTRYEDLSYISQSDFIDLPLSEMDMLFEKEFSNPDGSIISNFTLRITSQIEQSQTLVRKYLRYVSKFLGKINFKTLSTAGFMSGLKNKKQELFDDDQPLERDYFKFKKYIIATTLKGSIYAINNENGNVVWKISIGSNFVPLTDILNNLIFPFFIQRTTDSSMFRNQGVVTYGVIGGKTGILAFNMITGEILEQKIISKKLIRVEQIPKQNSERMKNLILFFGEQPNDIEYYPPLKESDIPLYDKPFYLLWISRETGQLRGTRFDFKKKYLQTVWVFNRNMGDEYIGNIVGKQVNEKTQSLGYVIGHNNVLYKYLNPHMIAIAFASKKTQHVTEVIILDTITGKTLYSSKLKGAQMPFKMVLCDNWLAMSFYNSKTRRQQMSVVELFDGHEFKDVSSINLWSKSYPSNFSVQSYLFPQGVTAFSVTKTDIGLTTRSLLVGMPFGSIAQISKRQLDGRRVFDVTQEQREEGLVQYIPELIFTPDQYVTGNNTVLQIRQISSHSAGLESVSHIFAFGKDLYCTYIYPSGKFDMLHDDFNYHLIIAILVSLVLGSILTRYKANYHSLKQSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT64</accession>
    <name>A0A0N5BT64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT64"/>
    <dbReference type="STRING" id="174720.A0A0N5BT64"/>
    <dbReference type="WBParaSite" id="SPAL_0000905500.1">
        <property type="protein sequence ID" value="SPAL_0000905500.1"/>
        <property type="gene ID" value="SPAL_0000905500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16474">
        <property type="entry name" value="RING-H2_RNF111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="535"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000905500.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69713" checksum="748847BB854352DF" modified="2015-12-09" version="1">MPFVTVFMDNSSVNSAISRSRSSPNIVQVQIPPSDIYSFNNINFQYMNPHFSNPSQHIGVMEHHVNLNTNRTNSLVIPNISNAVPSISQPIPNIYDFDIQQIRHLPIREPEDVIQIGIELQRHRAMEYERARANPFEPIPLSRTYQIQRNDLTGRITLIRDSNNDLQRRSDYITSSRDCYAGSSQPQHGISLNRSEETPDSQVNYVPYRQPSLPYNYEGQFIQQPIIHQTNGYQQPQHSISTSFHQNPVSRPSTLPSQRQKRPHGNTSSGSNQSGASRLPKMRRVNTTVDENPSCIPQNTSEPQERPGFTSVSSLQREIYENGDQRHGMSRPPPNHNHTSQEHTHSRNHFQNSWPMSIIEINRQIMNSLYTIEANIPHAYPHLVYPVQQAPIDPPNVIPPNARTSYIHQIPINGGSVFANPMTRHVGRHYMAHHPERVNLFNHVSRSVVDNMEAHGQTLEQFHQNNRAVGMTVPFISGFTPADIHYIQAFTHYGIPQVSTEAAPVGLSSEDIKKFTTIMPFSKDSNCSENESERCTVCLCDFDSGDEVRALNCSHKFHVECIDQWLSINKKCPLCREDVDKMRDVNEEPSGSGRNLINSTVHSNVHSQATIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV15</accession>
    <name>A0A0N5BV15_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV15"/>
    <dbReference type="STRING" id="174720.A0A0N5BV15"/>
    <dbReference type="WBParaSite" id="SPAL_0000968300.1">
        <property type="protein sequence ID" value="SPAL_0000968300.1"/>
        <property type="gene ID" value="SPAL_0000968300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000968300.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12094" checksum="373B533E2AA662CD" modified="2015-12-09" version="1">MAYNRPRNGTRPDHFLEQQNNELTENLANKAKALKRITIAISDDVREQNRLLNEMDDDFLKSNSLLGTTMKKLGIVTRSGGNKLLLYLVLFALFVFFVIYSLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVE9</accession>
    <name>A0A0N5BVE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4808 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000980800.1">
        <property type="protein sequence ID" value="SPAL_0000980800.1"/>
        <property type="gene ID" value="SPAL_0000980800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000980800.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25915" checksum="799FD5C7B53CB036" modified="2015-12-09" version="1">MEESMDYDTLSSTDSEDDIAYPIDVVNSVDDYYPVDNVDPVNVVESVDSHSNNDKSAARLKTTKMITDGVTNGKTAYAVNSEIVRNVCEQMNWEIGRDVRMRKYLTMPKVDPVTFELPGQLRFGNPVDDNGDFEPSHFNNYYNFPFAFTPLAADSLGGGRGGRPEGSFTDEFLTEFLVEIISISIFLILALIYQRFSSTRAPTNVPTTGIPGTAQAQESLTTNNGDADVIPPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVM9</accession>
    <name>A0A0N5BVM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 14 homolog A</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVM9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000988500.1">
        <property type="protein sequence ID" value="SPAL_0000988500.1"/>
        <property type="gene ID" value="SPAL_0000988500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000988500.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="85778" checksum="8B934495237F39C8" modified="2015-12-09" version="1">MSEWESEEEFDDLKHKQLLESLFKNDESKGKKKAFQLKKGAEEKVNIADMLSALKGKKGLDIVKKNFGIHTTKDLKKIQDKCLSNEENRGKGLKSKTLVAPMHKHAQDKIQAQVAYSDIKTELGEWNQVVSSNRVAEQIKFPLDQEKLHNLGNAERLEGKIPRTSLEQKMQQIISGSKHILDNNRPYTEAEEELLKAMDLKEAEEKIKKLQRERKLMSFRAAKNKYKAKIKSKTYHRIQNRSKRRKLVKEFEELVTKDPEAAKEKLAEIEKDRLLERATLRHRTTGKWNRNLIKYAARNEGVRKILQEHIRFGKELKAKLLGIDQDELSESEGEGENNNEEIEKKDYQTFMSMVAEEAAKEAKKEDKKDETIVSALLDGEKNPWLKKGLLKLRKAMKAKEEEKRGFVTKVSDKRKKEIVKEMDLDEGWTIVGPKDEEYVVSKEDVIEDLEVDEDEIEDNEEDIKFEDEEIESEEDVSKQEPSGKTIDEIFDEYFDSLITTTKLEEEAEDAMDTSNKIDDEEDGEPEAVDVPSCSLKRKGGDSLDNNENKKLKSTIDISLDPSKYLNLVTNNIEAIDDKINEHLDDGNRIHSLDQTNLIAEAFEDDDVISEFEKHKAKIEDEEREKDIDLTLHGWGSWTGAGIETKSKKEFVLKAPKKIRKDSNKHGIIIRQNVDSSIEKYQPDDVPFPYTSAKVYEAVIRQPIGMDWNTVNTNKELITPNVLTRLGKIIRPISKDTLKKSIKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWR6</accession>
    <name>A0A0N5BWR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Beta-1,4-galactosyltransferase 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWR6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWR6"/>
    <dbReference type="WBParaSite" id="SPAL_0001025600.1">
        <property type="protein sequence ID" value="SPAL_0001025600.1"/>
        <property type="gene ID" value="SPAL_0001025600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046525">
        <property type="term" value="F:xylosylprotein 4-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001025600.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="34392" checksum="1775125D6ACF55AE" modified="2015-12-09" version="1">MHRHHKILIKRCLIAIIFSFFIIWISRKVFFDKAVREYPSVLEVKPYNKLCVVVPYRDRLEELTEFVPHITKFLEKQKINNQILILNQTDGYRFNRASLINVGFLESDRLRCNYFVMHDVDLLPLNPELNYSHPGVGVVRHISAGPYHPIKRYDYAKFIGGILMLTMNDFKNVNGMSNKYWGWGLEDDEFYLRLQDSGLAKHIERPQNLDTNRENTFKHIHGKERKRDYKQIGNQREMSRKRDRISGLNNVKYKIIKREIKMFNYNSQATIIDVELECDLSWTPYCISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX49</accession>
    <name>A0A0N5BX49_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="3">Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX49"/>
    <dbReference type="STRING" id="174720.A0A0N5BX49"/>
    <dbReference type="WBParaSite" id="SPAL_0001038500.1">
        <property type="protein sequence ID" value="SPAL_0001038500.1"/>
        <property type="gene ID" value="SPAL_0001038500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="517"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001038500.1"/>
        </source>
    </evidence>
    <sequence length="842" mass="96880" checksum="293B845AE74D331D" modified="2015-12-09" version="1">MHLSSTSIWTSAGSALFDKTILYRNLETGVKKCTLFRACPYGGPIATYCVETLNNSFISYVEVKGNNNEIYGKIKTRNVIGIEWTQCHKLIIIFKDAKFSIYTPRGKEIVDQVCFDISAKQLGVLSYHIFYGPVNTGIAILTEAHQFFVINNVLEASVWKHRIFLDNNQNIEFWNVVCHASLPTTIFGYLSDNDCFFIAAQGSNSFKKKFDWSIENGKYIAGETNWNNTIVGLLHDTMIIQLVSNDLSTATHIIEVKQMPLINRIFWCGFGAPCLLDSNKILHIYTSKGDDCEIIFDSTIVASSEEDGLRIYSEECAYFVCPVAKSVENIFSTESSHPASTLYVLSKKEEDQYTTSFELLTTIMPSLEDAVRECLLAALNIFDEKLIVKLIKAANIGRMWESKVDSDYFAETLKTIKILSSLRADFIGMPLSFRQFQKIELRGVVDRLIDLGHWPLAVKICEFMELPLEEGVHRVFAHWAIDFIERCMNEIKSNSRKLTNEEMANLIFTKAERFPNISYAEIANEIYDRSSKDDNELIRLADILLDKEKDVSLKVKMYLQSKQWDKAILLADKSQRPDLYYTVINALKSLPYSKILVMTAKCPNIHAYFKEITEQDSPDDLINIYKANDEFVQLALHYISYNSNNINNPFMENTKLEHYKAALESFKNLGEKDTTNYLTEYINIFDTIKSYSSHEYSCDLSVKELFKLAVKEKHNKLAEEIGKRFSITEKEGWTWKLEAYSENGMWEHVKTMASHSKSPIGYYPYLEKCFHKDPNRQDLQFYISRLSTSKELIKGYLLLGRYDDALEHAKARKDIDSLNYMKRKFRNDSSFQEKLKNAFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX57</accession>
    <name>A0A0N5BX57_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX57"/>
    <dbReference type="WBParaSite" id="SPAL_0001039200.1">
        <property type="protein sequence ID" value="SPAL_0001039200.1"/>
        <property type="gene ID" value="SPAL_0001039200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001039200.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11738" checksum="E52997500444DACF" modified="2015-12-09" version="1">MNKLAKIEIEIKDNSCPMECYLDKITKTIFLNKTFKELTSAVGPDDWMHNTSVQISHKISLEDFLRIILSKDYDMDQLSSKSVDELLYMDDKLAKLFSDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXH7</accession>
    <name>A0A0N5BXH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXH7"/>
    <dbReference type="STRING" id="174720.A0A0N5BXH7"/>
    <dbReference type="WBParaSite" id="SPAL_0001050500.1">
        <property type="protein sequence ID" value="SPAL_0001050500.1"/>
        <property type="gene ID" value="SPAL_0001050500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="179"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="333"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001050500.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53022" checksum="5EBB724CDB2D574E" modified="2015-12-09" version="1">MRPNIETQQRQKQKDQMFSPRRIQNSIRFASDIDSGVSSNASSSLTINTCVPQCPKDKSSPREMNSYYRPRGQTISSRMPASPIPEHVIESADTTLDSKNRKESGDSCLGESFDENEDIFSFTRTTYQRRMSVPASVFNQANYAIVRQNDRQYDIVAAFCKDALPFESYLKSLTAYDIASKHNVVPYFHENLSVHKAIKAFVENGHQAGLVCDDKSKGISIFTDSDCMEAIWASNEEKLDLNLIKLREYLLLNDVKRDMISVSANMTAWDLGKLMVQSKVKRVPIYEEDKSSQDCLAFVTLQHLFTLTIAKILENKNFALADLTKWTLGEKNLETLDPIEVINQSSLLKEAVGRLLRNSLSVLPVIDEEEHVIGVITKRDILNELRFSERTYEEVMSLPVSSIIKHRQIPPLATAETIISDAIEMLLKSNLNTLFTVGLDYKLMGAVSYFDIMEYIINLHQDGKGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYG4</accession>
    <name>A0A0N5BYG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYG4"/>
    <dbReference type="WBParaSite" id="SPAL_0001081900.1">
        <property type="protein sequence ID" value="SPAL_0001081900.1"/>
        <property type="gene ID" value="SPAL_0001081900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001081900.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16696" checksum="CCBE9D5E09E2E6E2" modified="2015-12-09" version="1">MDIIDLQEHSQEEIQYGDSIENPIIIDDDDSDDENESLLPAPEAPTLNTYDFEKDSEDEILVADDYELPFMRDKIDEMDHSDQDEQLHELDDYELPFMEDDDDGSSISESDLCTTAPDMDEYNRICFLHQDYFPRRGTNTNSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYQ5</accession>
    <name>A0A0N5BYQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BYQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001090400.1">
        <property type="protein sequence ID" value="SPAL_0001090400.1"/>
        <property type="gene ID" value="SPAL_0001090400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF38">
        <property type="entry name" value="PROTEIN QUI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="4">
        <location>
            <begin position="565"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="899"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1374"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001090400.1"/>
        </source>
    </evidence>
    <sequence length="1617" mass="182545" checksum="E9BC5788114AA369" modified="2015-12-09" version="1">MFRVDKTIKEENVKSAGKDIIHRSSSVNNRKILLIFPTFEEFYYEKFEFIKNCIQDIQVCGAGLGVDIEWYTFSGNYDDFVNYDLLLQLLSEEHTIVICFIGNKVGYYMPPLEIDSNTFDALRQKLFEMSTDVKLLDKLYILKESKKGKKYCLQKNFLEDVLVIEKLIEMFKKMGNEDNKLLKLYINHVAEIMMSQQNANHIFVQRRFKGMPLEENNTIFSETTPMEYECIEGLKNTISQKCHENNVFSFILQCTSKDFQDWTTTKEGENYGKCIVEKISERIKQLIDNNCTIHLPTPISHSGCVDMFDIAKREQVTHQQYYIHSKPTNWAMKNDIESVNEKILNMTIEGKWCVTLNGDIGIGKTSQLLLLHETLQNNTNYISFIRFVGLTPHSIYDHEIWRNILLLLEDCSNSTKINTALFDDSLDVSKILKNIQNLAKKIDKKIYILFDNVHLMKSSKNINENFKFAKQISNLFIVSTMLENTQCNYMMSNDTITLKKPTIDESIEIIKSNASKSKIGNECLTNLRLYLTEHNENLAGALVVAQLLSYNIPVELSKSSVMNLVSHLENYYGETFIKKLIKYFVASPFGFTSMEMTTLLNFATKPLSYSQDEFPDLNISKGILLILTKYNMLFDCVAMDNQVVYKLKHSIFKRQFAENYLYDIGCNIKEANQMTYIEMASIYFDTSNYEDNEEVVFNGYMFPQPLIRENGNINLRKVSYQWKYLLEGGNAQNLKEFTLCNFEYIEALMRANGLGYLISVFDETCETLLDHDLLVFYLQVLIPSIDTLLRDSSQIAPECIGRLRYTRESNSQSLNGIVEQAMSWVDMYDSSPLLVPLTCWISPPKMDEILKVALPNWSGKSMIVSPTINYQNILLSGNSEDPSMIYLYHVPSQSIETTFYGHSKKVTSLSVASNGVNFASSSFDGTIKIWDIHNIDNVKTFEITKAKVNCCLYSHNSKFIASGTSDSIANVIDVDSGEIIATFPEHTGSVICLQLTSNDEFLIVGSGDFAVMVYSIEEKCLISKLEGLMAPVTCMALTTNDAFVVVACEDETVRVYSLISSQELHELSGHDCRVSSIAVSSDDCQIFVGVNSKIVCYDLHNSQIIDTLKCGEKFPIGSIQRTFDNSFIVAGCGKELHMWNIQCGNIKNNAVCEIVEDNSICCVKMSPDEKSTCCGSVSGVIALWDLEVCQCVWTQTHKLGSPITSIGFTDDSFYLISGCSEGQICLWEADKGQLIKNIKIHSLPITTLYFIGGSTQTYKVFSCDRGNNSHIWNLTPLDDSPNFYTVNISFGDVDSPILFKKHHKLILGEFSKNRHEIQIYHVYDSSVNLKAKAYHSEIITCYNFDRHERILVTGSKDQSLKIWQLDNGYLTQVLVGHESAVTCCAVCDKGNIVVSNSSDQRLIIWDAETGTVKSSIQTCHVINIVEITADGLVIITADTNGWIEAWSSTYGVILSSFNTYNTISSLVISIDSNRIVCPLVGIPQLPILCLHNTPAGIIQRHMSINEKSLHRINSAASYTSRTSIKQSPPKLENGKCLEEDLKNDSTKTTSQSLIVATSKPINKDKNYGSQENLKVGGENVRFRDNASVVSNARVSNAVNTKTGGNGEQLKSSLCNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD9</accession>
    <name>A0A0N5BZD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZD9"/>
    <dbReference type="WBParaSite" id="SPAL_0001113000.1">
        <property type="protein sequence ID" value="SPAL_0001113000.1"/>
        <property type="gene ID" value="SPAL_0001113000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001113000.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7760" checksum="CEE11D4B39D3A4A4" modified="2015-12-09" version="1">MSLLTVPNILKLKSYGIYSGRLYEGDIILTRSNARELIEEAMEEAKKKNVDISKFDTEIKNLGISGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZF8</accession>
    <name>A0A0N5BZF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BZF8"/>
    <dbReference type="WBParaSite" id="SPAL_0001114800.1">
        <property type="protein sequence ID" value="SPAL_0001114800.1"/>
        <property type="gene ID" value="SPAL_0001114800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002550">
        <property type="entry name" value="PRK02106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001114800.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66527" checksum="6DF2C4CF03516D29" modified="2015-12-09" version="1">MYLPQNCYKMFCNKKIIFNRRYSFKNTYNNDFKPRHIIIGAGSAGCVLANRLTESDKYDNVLLIEAGPKDYWWDWRIHMPAALMYNLCNDKYNWYYNTIPQKNLNNRTIYWPRGRLWGGSSSINAMCYVRGHPQDFDRWNREGAEGWDYLGCLPYFKKSQTHELSTGSNDPFRGHNGPLHVKQGDCTNELHQAFFEAGRELGWKILDNQNGYETEGLAKMDMTIKDGERHSASKAYLWNSIERKNLKVISNIVVVKIIFDGKTAVGVKCMDRKTKEIFSIYCDDSIILSGGAINSPQLLLLSGIGPGEHLKKVNIPLIHELPGVGSNLQDHLEIYVQHKCKKPITLYNKSSWKFPHNMIKSGLQWFIYKNGLCASSHLESGGFVKSSNDKEHSDIQFHFLPSTVHDDGRKNGTCHGFQVHVGPMRSKSKGTIRLSDNNPLNHPIIDPNYLSLEEDFREFKRCIELSRELFKQKAFDEYRDTELSPGKEVIDDKMLNDFIKNKVASAYHASCSCRMGDGSNSLDVVNAKTMNVFGLDGLKVVDASVMPSIISANLNATTIMIAEKASDIILGKEAKREDNIFSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0P2</accession>
    <name>A0A0N5C0P2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PI31_Prot_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0P2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0P2"/>
    <dbReference type="WBParaSite" id="SPAL_0001157000.1">
        <property type="protein sequence ID" value="SPAL_0001157000.1"/>
        <property type="gene ID" value="SPAL_0001157000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001157000.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33844" checksum="72E2348875FF38FC" modified="2015-12-09" version="1">MLGKIKEIIVEETRAIGLIKNEDESNKTKMVFYSKVKNTNSIDTSISYTLDFIVYENETSDSGVKVFRCTSIVPSIASGNDRLFGNNISIYQGMITSEILKEVTELVKEFKSLSSTVNNPFVDIFRQSLLGTIIVKYLPPKDFLSLERLNSTIKHCLNNGIARNYWVFALRRDFNITDSAADPLQTYKLHHRRLIADRAAENRPNPLLQEVFDPLRVPPRRPINPDPMINPFGGPQIDPWMDINNPFNLNPFRNPNGDLYHPGIPRQPFNNGQPRGDPRNFGGPFFDGRGFDRNDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C164</accession>
    <name>A0A0N5C164_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C164"/>
    <dbReference type="WBParaSite" id="SPAL_0001174200.1">
        <property type="protein sequence ID" value="SPAL_0001174200.1"/>
        <property type="gene ID" value="SPAL_0001174200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="448"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001174200.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="69513" checksum="1449EED774A4907F" modified="2015-12-09" version="1">XFCVYSDGFQIRFPPNTTGYKFKKISQLHNTQRNLQLQGHANGPKWLPRHLSKNCRKIVENMMNQVHESFVYIDDILLTSKDEDEHIKQIEKTFRIMEKYNTKITLEKTEFGKAEIKYLGFMLSENGIRPDPKKVQAIKEKEAPKNDKEVRAFIGMCSYFRRHIQNFAKIADPLHKIVNNYKWTDTEEKAFINLKEALINATTLKPPNPDKPYTIQTDASFQGLGAVLLQDDNPIAFASRGLKAAEKNYEIMRLEGIAILFALKTFRPYIYGLKTTIITDHKPLLALLRNKELKNALQRLQTAIMEYDLEIIYQPGNENHTADYLSRKEFNIITGLKENIIQPDEFKKYYNNSERKMLSSSNTIKTQHGERYLVPEAIKEELLKQYHAHPWLGGHYGYDKNIHKFKQIYYWKTLEEDAKKTWKECIECLKNKPQPYFQLKNSLGKIPTADYPCQSYSVDIMTVTDGLYYLIVIDDFSRFTYIERVWRTNTEQTAKELVKCFTRIEWPERIRTDNGKNFKSRNFTKYIKLFSVEHITTTANIHRSNGRVERIIGLFRQTLRANKHDDQDNALQIAIYVFNNTPQSKTNIIPAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C192</accession>
    <name>A0A0N5C192_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C192"/>
    <dbReference type="STRING" id="174720.A0A0N5C192"/>
    <dbReference type="WBParaSite" id="SPAL_0001177000.1">
        <property type="protein sequence ID" value="SPAL_0001177000.1"/>
        <property type="gene ID" value="SPAL_0001177000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000021">
        <property type="entry name" value="Inhibitor of growth 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="404"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001177000.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52701" checksum="3523F8D8B5614F25" modified="2015-12-09" version="1">MNVKGNLPNDGQCQFMTKKKKLLLALEVFTNESIKEYHKEFCSIFGLIINKSDSFKFGFTSGLRKPSRNTTPSEDSSSLEHWEKNKLDVGVKFYSIKEIDDFIDYISETEESALVQICITILNDPDFQAFVDTQFKVILHRNCQLKTYIVNIFKSLQFDYDGLNRCFKKLHNLSQQPSNYSDVEGKKIHLQILALLNNITMKLKSISELYGARIALLEEFNSKLAKQKIKLTNAIHDVDEELREATLNACHRMATDMTEENEVFKLFSKYSTLKKMSEMDMSDFEDDMDVDEDEEDETSSSINDMECDSENVSTTIQSPECFIDIPSIGSAPSITPIASPKSDTRVTSETNTVKKKPGKIKKTNRGDDDSDGEGQSKRIINKGKKANQLDLATLAEMNAAPDEPRYCLCDRVSYGDMVGCDNEKCTLEWFHFECVGLRSKPKGKWYCPLCRDDKPTSLRKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1J9</accession>
    <name>A0A0N5C1J9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1J9"/>
    <dbReference type="STRING" id="174720.A0A0N5C1J9"/>
    <dbReference type="WBParaSite" id="SPAL_0001187300.1">
        <property type="protein sequence ID" value="SPAL_0001187300.1"/>
        <property type="gene ID" value="SPAL_0001187300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF28">
        <property type="entry name" value="BUB1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001187300.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44934" checksum="8406E5B2053A6D1C" modified="2015-12-09" version="1">MDSKSKIEEDWMLNRENIIPLKSGRSMKILNSVLSKSITIEEAEKKFEISFEESKSHEDPLSVIWEYIKWFENVFPTGKQKTLFPLLWKSVNYYSNFEELENDERLVKLWLKLCDNYPTRSLAILECAFTKGVGRYCASFYISWSEIYEAWGSETKAREILKMGLKYGGTPITSINRAIDNFEMRCIKRSLEKNNSCDDEDSDMDTDIQNEEYFEPEPIRRSVLGDLTMGVKRDVIKRKANPENNKENACNTTGKFNVYHDDRDFNDLDNDLEYQELFGYFEKVKSINSISIKENENRGSRKGGLPKLKEEKHNPVKEFEVFCDEDCDEGVVSKNSESKLTEQKAVKVISKRMCKKVFLKEGISVVERFVDNWNGIIIKSENGMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C244</accession>
    <name>A0A0N5C244_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4126 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C244"/>
    <dbReference type="WBParaSite" id="SPAL_0001205700.1">
        <property type="protein sequence ID" value="SPAL_0001205700.1"/>
        <property type="gene ID" value="SPAL_0001205700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001205700.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12516" checksum="91AC4F4870E1DE8F" modified="2015-12-09" version="1">MQCYPKQGHYDPLNQCQQYCETPFASAGNLMENVIVFILGIIFKLFLGVLEEYCPRIFRRLTRRPQEPAAAPEPPTPSTSTPPPDATSAAADAPALSQESDPVAAASSAPAPIEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2J3</accession>
    <name>A0A0N5C2J3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2J3"/>
    <dbReference type="STRING" id="174720.A0A0N5C2J3"/>
    <dbReference type="WBParaSite" id="SPAL_0001220100.2">
        <property type="protein sequence ID" value="SPAL_0001220100.2"/>
        <property type="gene ID" value="SPAL_0001220100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001220100.2"/>
        </source>
    </evidence>
    <sequence length="262" mass="29906" checksum="D5E2B8ADF7085FDB" modified="2015-12-09" version="1">MRGYYLNESMFKEEDEYLLAFAINVFHKDVRNLNKFFKDVLVVEIEFPMDRSSVNSILNIYECMESLNDKNYKYLFLLQNDDVLLQTDRRLVQIIMLYNGSLDIDFGNPFTSRPVNVIKNVSFKHKGLNIFKKVGPFLVLKFLIGFLVVIFSVLGFLVVTFPVFVSLVGTFLGFVSLVGTFLVLGFPVVLFLVLGFLVVILSVLGFLVDTFLVLGFTVGPFLEFLYSKYSSYNEAGLVFIDFPSFNTIFACSSSSRRSFIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Y7</accession>
    <name>A0A0N5C2Y7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor with AP2 domain(S)</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Y7"/>
    <dbReference type="STRING" id="174720.A0A0N5C2Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0001234300.1">
        <property type="protein sequence ID" value="SPAL_0001234300.1"/>
        <property type="gene ID" value="SPAL_0001234300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF40">
        <property type="entry name" value="SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="8">
        <location>
            <begin position="674"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="781"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="972"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001234300.1"/>
        </source>
    </evidence>
    <sequence length="1191" mass="136776" checksum="905F4F0B31526F64" modified="2015-12-09" version="1">MECGAYQTPQSSVSCSSNIEMPFNGTNGYFSGSISDNVEISNSTSEMVPYKHSGHEINMFSNYQYNIPCENVESINGRKNSVQPTFSHSSNETCNMEQMRNPQQQFSNEYINNYNQLQGVQNYRIPRNEKIPTNNKLVTSNCDFFESNQNNYCYFCPQESNLSESILNSNHSTNNCPSSFSSTERNISNREIESANYNQFPSILNNIPYNTEKKDSFDIFSTPKTPVSEERYYNSNNSIGCTYYNTAMTTTNGNNNFNEDLMQNNNHVNSHTFNPYDEISRKYSYDNFGNPSALNNNNSNEEYISNNNTFSFSQSHQQQPQHHTQQQQHQLPNLRKGSVYDGMLYRNHNCHGNSINSNVNVDEKYNDGNNLNDKFLQNVTKYDDVNKDNYNNKSLSGKYGDLKHQRRMSLQHNLFYGRKDSYGGNKKNYSNEKLHYNQYPYTLDQNTHHKSSESYYTPPMEVGRGETSYKVYDSIKEKVKKLSIKEKVVSPLNSVGILNIDYDHHQMEEIKEEEEDICITPTFNQSPSVSSNEISKTMKSIGDDNDRQNTFFSSNINNQSNNNYLDINSILQQKNIMIQKRAPFRPRISIMKVSKRKCGWACEGSNKNTFDVEEFRRQLLKAYEDMKTTNNYNLLRSTSNDIQSKNSNIFDNNITIPDNKDSNELLQSFNSDKPYMNIGIEHQAKIKPWTGKKIKNHEEKKESAILLFDPKVISHLTQETVAAYEALACSELMPKGGRNIELALHILYENKGNIQAAVMDLMRIDQLEWDMYPIVNNTKYLLTDYWSKLEMNAFSEAIFKTEKNFNKMSREIGTKTTKQCIEFYYFWKLACPEDYRKLKNLLRKKQLLRKALCKIPIEVYIKIKEKIDNATEEDELPEIEVGDDDEEMPELVASITKNDSIRIEPRKQLETSAKVEIFRPMETISSNTSLDINTSSDNNTLNIEIKKCCVGESIQEPSTSYSWMHSDNACSDNTDNITKGQEKSTPTIHPPLTPYHASPATPKKGAQPQADGFFHCRLCDKRFEKVKSLNAHMKSHAMKARAEAEAKNQQSTQQSKQQQPQHILLNEPNINQNIMHSQHQQFNPLPTRPLNLTGVFPDTNNITNLFTAANPLASQFQTTHRDLANTLFGQGNSSEPLNPILQSMFPQSLIPNQQTLNLSNEKLLGVLPNNVPFQVSNPYTNTNRNTPTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Z6</accession>
    <name>A0A0N5C3Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Z6"/>
    <dbReference type="STRING" id="174720.A0A0N5C3Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0001267900.1">
        <property type="protein sequence ID" value="SPAL_0001267900.1"/>
        <property type="gene ID" value="SPAL_0001267900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001267900.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14421" checksum="E34A9EB5D5662BE9" modified="2015-12-09" version="1">MDFLKYLNLVIALLAKTVSFLSLIVFSIQAKENPHSVGKQRVVGSRQSGVVLADVVHGFTGAKLNVNTPSSLDDKSAMPNNLSLVLGAMKNDGVDLMNNNIGDICNGKPKIVLGLIWQMILHYDIRKSIQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4D7</accession>
    <name>A0A0N5C4D7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4D7"/>
    <dbReference type="WBParaSite" id="SPAL_0001281800.1">
        <property type="protein sequence ID" value="SPAL_0001281800.1"/>
        <property type="gene ID" value="SPAL_0001281800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895331" evidence="2">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001281800.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14748" checksum="C0A3D8579C46C350" modified="2015-12-09" version="1">MFKYCLYFLIGILTLKKLSIYGGIINRNDMNNFDPKIWSELTLFEHKSKNIAPELWKKSNDDDKITFPYRIGKDLQLDINYEPFKEVKDDSNIPTIWSFMNNDGNGERKQTNEEETNDPFAITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4H0</accession>
    <name>A0A0N5C4H0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4H0"/>
    <dbReference type="WBParaSite" id="SPAL_0001285200.1">
        <property type="protein sequence ID" value="SPAL_0001285200.1"/>
        <property type="gene ID" value="SPAL_0001285200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895336" evidence="2">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="121"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001285200.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31377" checksum="98F779CD7D09F6E1" modified="2015-12-09" version="1">MNFLPIIALYIIVIFHIAYVPIKANPSNSDDDEEPLLGGKDLDRTNSVRKKSKTRSSKLHSRRWSHISHSDNSVRRPSLDYQRCALNIKSYLGNLKIHSSLYSTVWSGFKYIDVVHNVYRDYIRRIILHINLLRMLHGACPLQESITLDELAQISAKTFSKNNLAKIRYEGYGVSKDYVHCFRLADVVERLYSTRIFYSYNRKYGKKLAKQFTQLIWRSTTQIGIGISKWRDHFHVVIIYYPKGNIEGHYGNNVFEKKISWKEMAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C631</accession>
    <name>A0A0N5C631_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C631"/>
    <dbReference type="WBParaSite" id="SPAL_0001340600.1">
        <property type="protein sequence ID" value="SPAL_0001340600.1"/>
        <property type="gene ID" value="SPAL_0001340600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340600.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20282" checksum="0139C93883D0059D" modified="2015-12-09" version="1">MEVIYSEALKKDHLKSPEELPDLNRLQLILKRLFYYNERIKSTNNAYNVEKLEASINEIFKRAKLRQPIEILSNINEKSNGLFVNTQDDKKTYVFAIGTTPIVLSENLEVTIKNWLMFNLLSPSFKMNEPFNRLYELLITITGGRGNHTTKGRAGKCVHVDQLINDIKNKGFETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7C7</accession>
    <name>A0A0N5C7C7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7C7"/>
    <dbReference type="STRING" id="174720.A0A0N5C7C7"/>
    <dbReference type="WBParaSite" id="SPAL_0001384100.1">
        <property type="protein sequence ID" value="SPAL_0001384100.1"/>
        <property type="gene ID" value="SPAL_0001384100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001384100.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40687" checksum="E3A739D15BB11BD0" modified="2015-12-09" version="1">MTSLGRVLVNIGKRSLCTSTSPIDEVAKKVNVCLIPGDGVGPELTQSVQEVIKHTGIPIEFEEVFVSGIHYKRSTRLSDVLEALRRNNNVCLKGVIQESVYNRDNELKGLNMKMRRELDLFANVVHIKTMEGIKTRHGKELDFIIIREQTEGEYSAIEHESVPGVIECLKISTRPKIERIAKFAFDYAMKYNRKKVTCVHKANIMKLGDGLFLKICQDTAKLYPKLKFESMIVDNTCMQLVSNPDQFDVMVMPNLYGNIIDNLAAGLVGGAGVVPSKSIGSDFVMFEPGSKHSFQQALGRDIANPTAMILACANLLHHIHLDTYSDALRKAVEKTIKEGKVRTRDLGGYDSSTDFTFAVIDNYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7M4</accession>
    <name>A0A0N5C7M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7M4"/>
    <dbReference type="WBParaSite" id="SPAL_0001393600.1">
        <property type="protein sequence ID" value="SPAL_0001393600.1"/>
        <property type="gene ID" value="SPAL_0001393600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895538" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001393600.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8436" checksum="C772072ADDEDE9EF" modified="2015-12-09" version="1">MLQLAIVAFLVFEIQRLYSLPIADCNSNSSTLSVKSAKPPPWRNRLARSAVNRKVGGSSPPGGVGNFLVHRPGSSGCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7V4</accession>
    <name>A0A0N5C7V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7V4"/>
    <dbReference type="STRING" id="174720.A0A0N5C7V4"/>
    <dbReference type="WBParaSite" id="SPAL_0001401600.1">
        <property type="protein sequence ID" value="SPAL_0001401600.1"/>
        <property type="gene ID" value="SPAL_0001401600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001401600.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="86192" checksum="2E184CFE96229595" modified="2015-12-09" version="1">MSEKKIISNPAPHSALEELCFKHFKIAHQECREVNYDNIATEAMVINNKLKTTEATKFANLLIESTIEDTNNHEKERYQKYCKIMNIPDKCVDFFNEHNVTDDHIEENVKVNYRTLSRKEHKRPFSAISQNMDNIDSSDSEYDSENDINCDRNSDISFVSEQFSILEVESINDMEEDSDFECDEEFEDESGNESEFENESDSDKNKFIVWHPTKSARNIIIKNIPESASEIYNQTVININWKSLIKQSYELDSETPSNYVVFKRIVYKVWEEELERVNKEKDSMIKKISFDVDGYRHLKDNGSEIIGLISKRHYNEQIIKKVDVLAESIDTNVYIYKFQKEIVKDNVTMHYYRCKSCKEIEDKLAQARKKGIQINDADANEKSATLIRKYNNETLIEENSGFNKFHRKHCRPYTMYKVLADQFAKKVKEIVSTGLTNFDSAYEIMRYSSICLATLHNTQYHNIMVEVLKITTLREECQRINEFKSKNRIEFIESIKYTINSENNTKEKLLRYKKDSVSNMGLKDIIVENDYMIFAAPLQYIMSAECDIWMADGCHSLLDRKQYEQVYTIHDNFKKVDRNNKYIFKNWLTSAEQRKLICKFGKDIRTTNVCESFHTVCKLKGCSDVYTVERSFKNIRILFDNIEIELKRLHMSNRDLPNQKLKYRFRNTDNCIKFLDEIGSKIFVEKVVADEFGNYRHEGIQEICQERKHIWKKVMLDMEKTLSLHLLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7X2</accession>
    <name>A0A0N5C7X2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7X2"/>
    <dbReference type="WBParaSite" id="SPAL_0001403300.1">
        <property type="protein sequence ID" value="SPAL_0001403300.1"/>
        <property type="gene ID" value="SPAL_0001403300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001403300.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39647" checksum="C1D5BD1AC311EB40" modified="2015-12-09" version="1">MIYSKSFLIFSIILLVGIISTYHLEKSKLDGLVEHDLNYENRALINNNLNSLSSQNFQEESKLDVAVRNKRQASEARRRRRRRRRRRRRREQRAQRRQRQQKMRRLRQQRQRRLRQARRRQAIQRRKQQTRLRMRRRQAQRRMKQRQAQRRRRQRLTAMRRRRQERLRLSRRTTIRPISPPRKVTIGRSRTPPRSSGRGAGGRGSGSSRPRQHEPSEDEEGAEGEEEGEGEVEDGEGGEQKGENDYGEESEGGSEDEPQSPEERESEQPEEEEEGEEQEAEPSGEQDGPADTEAEEESLPGDDVGEEEKDGGSNADDEEGGDDEGDGSNADNDDEEPEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Z9</accession>
    <name>A0A0N5C7Z9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PUR DNA-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Z9"/>
    <dbReference type="STRING" id="174720.A0A0N5C7Z9"/>
    <dbReference type="WBParaSite" id="SPAL_0001405900.1">
        <property type="protein sequence ID" value="SPAL_0001405900.1"/>
        <property type="gene ID" value="SPAL_0001405900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611">
        <property type="entry name" value="PUR-TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611:SF0">
        <property type="entry name" value="PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04845">
        <property type="entry name" value="PurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001405900.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30297" checksum="7615FBC684C6F696" modified="2015-12-09" version="1">MMVGSKGNNNFGGKKGRSRDSKTLSIQKNEINTRQKDDKNNENIVHSYYTRSFSFGFKKFYIDLYNFDDGKVMKLSEVFGDKQRISIHVPINALEMLIQKLDIFNDYHNDTQSNHEPLQQTIVYNGQRFALLYGSNDKGPIVIISQVSKMAGTHAQIKINPNNLPKFIKELTETLEEINPQNITRNIPHYPCSGTVECKNEPKTFFIDPVVRENEKCIRISQLKLKESSTMMNTNIHIPFEDLNEFRDSLIQVIEELNNFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAC2</accession>
    <name>A0A0N5CAC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAC2"/>
    <dbReference type="WBParaSite" id="SPAL_0001484425.1">
        <property type="protein sequence ID" value="SPAL_0001484425.1"/>
        <property type="gene ID" value="SPAL_0001484425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895658" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7381" evidence="2">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001484425.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21797" checksum="032C47E196FC4BD8" modified="2015-12-09" version="1">MYCGLKIFCCILYVLHFVECQIVTFYYTSGHHKRKHVYKFKTETYYSKRAVAIAIVRDSQDYSPCCLYMQELKYEAFSRTSRNNRYPQPEPVLAYQKLEMYRERCSFKDSCPSKHDINVYYRSGLVLYECNGRIFRSFNNAKLYARRGSRRYYKQGMDSKIFFMNQQYRSLTKNGKVQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBF7</accession>
    <name>A0A0N5CBF7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBF7"/>
    <dbReference type="WBParaSite" id="SPAL_0001522300.1">
        <property type="protein sequence ID" value="SPAL_0001522300.1"/>
        <property type="gene ID" value="SPAL_0001522300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001522300.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28852" checksum="EEECFBD0171A83D9" modified="2015-12-09" version="1">MDHNITFDDAVEGFRIAAIKYYEQNILVSGKTNTGKSSTVYLGVAVHYISHNNNGEILQQVSQSNTQSNFNVKSNICGFHDEVVQDDFRAFLFIMNYKTDTCRENVRTMRFMLPTLNIITLTGSLNWGILKNSIMKADVILIKWDQLFHFHNVMRSTKFKNLRFFTMDECITMTSDHQIASIEIFMKEHFYCHLIQMIMVSCSFSNDKIAALRKIIGTDYARIDLTRCLTVSRISPPQRLENLYKPFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCH2</accession>
    <name>A0A0N5CCH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCH2"/>
    <dbReference type="STRING" id="174720.A0A0N5CCH2"/>
    <dbReference type="WBParaSite" id="SPAL_0001558100.1">
        <property type="protein sequence ID" value="SPAL_0001558100.1"/>
        <property type="gene ID" value="SPAL_0001558100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001558100.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="54081" checksum="19E5A13FB6D67237" modified="2015-12-09" version="1">MDYITSFDIRLEKTIYYPGELISGCVILDNCKDIEIQNIFVALRGKAVAYLKTIRGNDKKIVSDYQYLLNYDQIVFGKEYEIDERKESLLKIDRKNSTNIQSKSESQLTTTILPKGSHIFDFSFNLKKENLPCSLETKHCTIRYYIKVIINISRNTSPQGIKYITIIGPQLDCMEEKYMSSITSQDHRLKCLRFCQRGSIGLRMNLRRCAYVGGESLWLRADIENWQHFVVFLKIRLYQNVEIRVDKRNYCEQKLIQSLAMEYRSNGIPESSRYNFDSTKEFPIKIPVLPPTMIGTCRLVQIYYTLKVCLEDENQKEDLLLDFPIVIGTIPYRYPPSMQGTISYDFCTPFVEGGKYISPEFKLIEDSNDEHKIFNRESTILTFNIDENEIPKGSCLEGNMEDGQESECDYVLYRPVYVRYNEKDAVNKAKNKVNCSLDDLPSIIPIAKAQQELIKKEQKIINTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDE9</accession>
    <name>A0A0N5CDE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-rich adhesin for platelets-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDE9"/>
    <dbReference type="WBParaSite" id="SPAL_0001589500.2">
        <property type="protein sequence ID" value="SPAL_0001589500.2"/>
        <property type="gene ID" value="SPAL_0001589500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001589500.2"/>
        </source>
    </evidence>
    <sequence length="428" mass="46486" checksum="3A2B3A089A2EB42B" modified="2015-12-09" version="1">MDVDSTLTALSINQENDLGEDVSLRTATGEVSTASSNLHSFLQTATEELCTGVSNYTTYLQTATGEPSTAVSNQSSYLQTATEEPNTAVSNNYSNFVTTTEMGSTIVSDLDTYIQTATEEPQSAALNQVTHLQTATVEPSTAVSNQTSYLQTATEEPVTALSNLHSYLQTATGEPSTAVSNQTSYLQTATREPSTAVSNLDSYLQTATIDNSTAIQNSFVSTAISGPPTVVQQNFDTKSLCPASERSNYTYSQYSCSPAEISVTMNSGPSSEITSIGNTTTNFEYSQYSASPAEISVNLNSGLTSKTSSIASTRSDFEYSKYSGSVNEISVEFPDKLKTSRSNSLVSSTQPSEMSVTMNEQSFYSICERNFDEVDVELDGKDTPLIKEMFSFFKTYTKHRNDPFYDPSYDLQSDDEDSDGQRLIFNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDH2</accession>
    <name>A0A0N5CDH2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDH2"/>
    <dbReference type="WBParaSite" id="SPAL_0001591600.1">
        <property type="protein sequence ID" value="SPAL_0001591600.1"/>
        <property type="gene ID" value="SPAL_0001591600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001591600.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17551" checksum="2E55CD2EFFCE4795" modified="2015-12-09" version="1">MNNNKKMHMWTWFHSEINDTVLFKNWHITTVNDMVIACVIFICVGILLEALKWVRWRLDLIYGEKLENYNHKAFYLQIIDKVNILKTLLLILQMIISYILMLVFMTFSTWLCLSTTIGISVGYFVFGNRVFNSPENEMFLRKRKNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEB8</accession>
    <name>A0A0N5CEB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEB8"/>
    <dbReference type="STRING" id="174720.A0A0N5CEB8"/>
    <dbReference type="WBParaSite" id="SPAL_0001620800.1">
        <property type="protein sequence ID" value="SPAL_0001620800.1"/>
        <property type="gene ID" value="SPAL_0001620800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000189">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001620800.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="31846" checksum="28C9A77E477769F3" modified="2015-12-09" version="1">MNPLKSLTIDSSFNNTTSSSPNSSIYGDIPSTSSSMNSLQSPNSLNSSILNNNQLKFSIDNILQPQFGKNMLDFALNPLNLFAAAMAANTFLTQNPQITLDDKLATPTLPIFSVSSTQNSLAAAFSAAAASMSLSTTSSDGTTFSRINNMTPTSQSESPNHNSPTTSNSGNSNLPAWVYCTRYSDRPSAGPRTRKMKRKDSITGEDEKRPRTAFTAEQLERLKQQFLDNRYLTEKRRQELAHELGLNESQIKIWFQNKRAKLKKVSGNPPTKSNSMNIPILPQGLYMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEV5</accession>
    <name>A0A0N5CEV5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aurora kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEV5"/>
    <dbReference type="STRING" id="174720.A0A0N5CEV5"/>
    <dbReference type="WBParaSite" id="SPAL_0001639200.1">
        <property type="protein sequence ID" value="SPAL_0001639200.1"/>
        <property type="gene ID" value="SPAL_0001639200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="66"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001639200.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37428" checksum="E674BE22AC7374FA" modified="2015-12-09" version="1">MSESTTVDNVSVDNKLIPNEVSENSQKNNQDDGKENVENIENNKEEKGKDEKAKDDKVKMWKLDNFEIGRNLGKGKFGNVYLAREKISHFVIALKVLFKEQIEKFQVRVQIKREIEIQYHLRHPNILRLYGYFYDDTRIYLILEYAARGTLFNYLQKQKVLPDAVAAKYLYQLTDALDYCHGLGVIHRDIKPENLLISVRDDLKIADFGWSVYTPDSRRQTICGTLDYLPPEMISQSSRSYDSKVDHWSVGVLVYEMLVGSAPFGDAAPKNTLLKISQARFTIPDSVHKKAADVIQSLLKIAPSARASMSDVKNSEYVKEFYRTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFZ6</accession>
    <name>A0A0N5CFZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFZ6"/>
    <dbReference type="STRING" id="174720.A0A0N5CFZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001677400.1">
        <property type="protein sequence ID" value="SPAL_0001677400.1"/>
        <property type="gene ID" value="SPAL_0001677400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895822" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001677400.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10035" checksum="C61762B88ED540DE" modified="2015-12-09" version="1">MNIKKFFFVFAIVVTIFGTTANCNTYILDDVYDEPHQVERMKPKRAINPFMDSIGKRNEFFSGQPRRYFDVLAGQSLGKRSSYNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHG2</accession>
    <name>A0A0N5CHG2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorting nexin-27</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHG2"/>
    <dbReference type="STRING" id="174720.A0A0N5CHG2"/>
    <dbReference type="WBParaSite" id="SPAL_0001727900.1">
        <property type="protein sequence ID" value="SPAL_0001727900.1"/>
        <property type="gene ID" value="SPAL_0001727900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="135"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001727900.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="60275" checksum="1B2FEF7B3E6F2C40" modified="2015-12-09" version="1">MVDESFTSSRIFDSNKGSGIGNIIYEPHYVSITRCETGFGFNVKGQISEGGQLRSINGQLYAPLQHVSAILHGGAAERAGLRMGDNILEVNGQNVEGATHRQVVELIKNGGDKLQLLVISVPEYEYHEVDFEYDSSDYYSRYDYTEKRSLPITIPNYQVVKSSCESFVAYNIHMAGRHLVSRRYNDFIKLHKYLKDEFSDYDFPKLPKRWPFKLSEQKLDTRRRGLESYLEKLCAVKVIADSEIMQEFLMEETEEYSRFLDVTLKIQLPDTNVVSLMVKKNEPCWQVMKEILERMEVDNDVIENVGIFELINDNFYRLLGDEEMPHYIYIHNYSSIAVSSISFRKLIFNIEEERRLCKRSDLFKQLCYYQVINDIDKGILNTKDRTIQLRSIQSIDRIDEYLETARKLDDYNKITFPESESNFKSKVILTISYDKVKIDFSEPEKVSQIIEWLRIQRYYISNQNSTFNIEFKNDNKIQILQLFTHYCSSMFLTFEKVIQERERLEGKDGNQGEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIN2</accession>
    <name>A0A0N5CIN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIN2"/>
    <dbReference type="WBParaSite" id="SPAL_0001768700.1">
        <property type="protein sequence ID" value="SPAL_0001768700.1"/>
        <property type="gene ID" value="SPAL_0001768700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001768700.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9759" checksum="D889D0B1DDE449EE" modified="2015-12-09" version="1">MSSFSEILRLAYSWLLKTSVNSLMSQYELSICNHGFISSIFSTTSVSSAEKERLCYWSTVNNNVGFENSKSGVNIDNIKKQGHLGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Z2</accession>
    <name>A0A0N5B1Z2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APG6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Z2"/>
    <dbReference type="STRING" id="174720.A0A0N5B1Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0000009400.1">
        <property type="protein sequence ID" value="SPAL_0000009400.1"/>
        <property type="gene ID" value="SPAL_0000009400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="4">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="3">
        <location>
            <begin position="220"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000009400.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47599" checksum="CD8956A3D609027A" modified="2015-12-09" version="1">MNFTSSSQSNSLLSDVNLFCIDKQDEDKINCEIKCCNCGEVLTLHKSLKDNDTSKIMEYSSINNSKLSFIQGNTVTMIAKSDSPFHVPMCNDCHLVLVEDLRLKNNILDEQNKGYRRCLTKITSSENEIKEEELEKTIKLKKLQEKERTLQQELKKLEDEERELESDIKKLEEKEGQLQGIEKKLISTLKVHHGDMVNFSLKKLSLKLQETFAIEQLNELRKVNMLNKTFYIYVNNKEIGCINDLRLGRLPDQSIPLNEFNAAWGQCVLCLHVLFELLGLNQYPYQLIPMGSQSIIREYTSTGVKDYKLYESSWTIFKVYMDDAISVYVKCLQKFDSEFCQQNNIVSGTIFPYTIRNDKIAEEVVNASNEASAIWYSIKTQFQKDERWTKAMKLMLLNLKNAIMYAASVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B234</accession>
    <name>A0A0N5B234_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thymidine kinase</fullName>
            <ecNumber evidence="11">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19130"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B234"/>
    <dbReference type="STRING" id="174720.A0A0N5B234"/>
    <dbReference type="WBParaSite" id="SPAL_0000013700.1">
        <property type="protein sequence ID" value="SPAL_0000013700.1"/>
        <property type="gene ID" value="SPAL_0000013700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001270">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000013700.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26802" checksum="B17FCB24811ADDBC" modified="2015-12-09" version="1">MGFNYYDIKNKKKHGMIHMIIGPMFSGKTTELFRLANMHILANKKVILVKYEKDNRYDSKFASTHDEKKMEAISALYLKDVFDEIKKNDVIGIDEGQFFDDIVYVAEELASMGKLVIIAALDGDFQRRPFESITNLYPLAEKIKKINAICRSCGYLASFTFRTTSCSDLEIIGGDDMYKAVCRECYYKFKNMQLQNKSKNSIDKISSNLSDNLKKSETETNNLKNASLSVRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2Q3</accession>
    <name>A0A0N5B2Q3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2Q3"/>
    <dbReference type="STRING" id="174720.A0A0N5B2Q3"/>
    <dbReference type="WBParaSite" id="SPAL_0000035700.1">
        <property type="protein sequence ID" value="SPAL_0000035700.1"/>
        <property type="gene ID" value="SPAL_0000035700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF1">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000035700.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35903" checksum="D549807B518D42C5" modified="2015-12-09" version="1">MLMKKILPSNYKEILKLIDKDISYLNIYFCLKSSVYNWSPTTKVHAWKFYDDVFTCYAVLNIHTHGKPYLFIQTNYEIEDYEKGNEAVNLLFDDLLKLIEEVEEIGIVCSDIFMRTFRKLFITQSPFVNSSIDEPVAFFYINDENYDKYIKDGATLEEEFKVIQLPPSYAQTMIDQLLFAGNGDVELAKHRLEQYPSVGIVEKNSNQIASFYYNDGYGFLAHQFTFSEFRRRGLGKACEIELSKLNKELMGVIPLKAVSLNRKYVISLAGRLKYWSRISNKDMNHPDVYWTFFSKNETQKKQMYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B397</accession>
    <name>A0A0N5B397_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B397"/>
    <dbReference type="WBParaSite" id="SPAL_0000054900.1">
        <property type="protein sequence ID" value="SPAL_0000054900.1"/>
        <property type="gene ID" value="SPAL_0000054900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF5">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000054900.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19539" checksum="E447D69643BD199C" modified="2015-12-09" version="1">MAEAIFDEEEHDFYLSPKHAEYSAKEGGASRHLMVNSSTMRIVVKIKCSNNNLYRISPVYTALEPGEAQRLQIVRDPGEAKIDKLIILYMKSPIKSPHEAFMNTKSSLVKRCMIVLIAYNKHPQFTQPRLPPPGSRAMDSNTSKGSILGSTTLRNDGLKENKKISIYDKKLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3T4</accession>
    <name>A0A0N5B3T4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3T4"/>
    <dbReference type="STRING" id="174720.A0A0N5B3T4"/>
    <dbReference type="WBParaSite" id="SPAL_0000073600.1">
        <property type="protein sequence ID" value="SPAL_0000073600.1"/>
        <property type="gene ID" value="SPAL_0000073600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF5">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000073600.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="53032" checksum="0EDBD93BAA6B99B1" modified="2015-12-09" version="1">MKVINGTIENWSSCSNINISKIHEYGLRCINNGGMYYDICRNECLQDFTRLNLGDGLPLETLMYGSIFPFLIFIVVIANFLIALVLSQRHMITPTNVVLRYMAIADLCVGLVSFPWTFFYYTLRFLERPEKVDLWWCYMYKYTMDGLPPIFHNSAMWLTVLLAGQRFISIEYPIRSRQICSVKNVRLCSIVIVVITIICGLPKFFDSNVSLYDGWMFHRNGHISHIRTCRSEFTFLVNALGPNTYFNLYFWTRIIIFILIPSILLTFLNLSLIRGIRKAEKRKERLLKEKRAREAEKQRDSNSTSLMLVIIASIFLIVNLPQAIFISIVCFCNTFEIDLQLMSNDTGIIFKLLSNMMVMATYPINFGIYCFMSSAFRQSFKALLCSKNWKASLLNKSSSKARLFSTINSNHTESTIGKMISPSVLMENCEEEMKVTEILVKSKNDSLPDDNRCMDTIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B400</accession>
    <name>A0A0N5B400_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B400"/>
    <dbReference type="STRING" id="174720.A0A0N5B400"/>
    <dbReference type="WBParaSite" id="SPAL_0000080300.1">
        <property type="protein sequence ID" value="SPAL_0000080300.1"/>
        <property type="gene ID" value="SPAL_0000080300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893854" evidence="1">
        <location>
            <begin position="22"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000080300.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50099" checksum="CA0BD29FBDF860C6" modified="2015-12-09" version="1">MVIKLLLLTFLSIVCLSKIEAFGQIQVNKNGLDYFAEIGMKKLISIMENETIPSYSGIGPQRLSYSLIGINVTSFKVAEKPNKLSLFGPKRLTATFRNLKIKISVNYTLKYKNNLTITDNGSFDIYINNGSLCLGMDVSRGEPFHFHPSVCNVNLNNTDPIEVSGKIESWIYDEFKSSVENYIKPNLISTLCDNYEYLLEDYLKVLIANVNEPIEIDKNNNGTLSGFIVDYTFPSIPYVDNQFGIEIPILPILYNKSNKSKELKSNKYVAKKFTSDKHMCIDLDFVNFAQYLVETISSNKTIQTLGHDLIRSRLHSKVHDFFKCGCKEESFCISDIIPDLDRFCSNYTEVSMIFNSFKLTNINVENDVIYGNSSQVVSFEIDDNNKTIELFKLELYPEYILRRDDIQISSNKISGEVDIDVCKFKVISSMESRKLLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B452</accession>
    <name>A0A0N5B452_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Programmed cell death protein 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PDCD10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B452"/>
    <dbReference type="STRING" id="174720.A0A0N5B452"/>
    <dbReference type="WBParaSite" id="SPAL_0000085400.1">
        <property type="protein sequence ID" value="SPAL_0000085400.1"/>
        <property type="gene ID" value="SPAL_0000085400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009652">
        <property type="entry name" value="PDCD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053750">
        <property type="entry name" value="PDCD10_Homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250">
        <property type="entry name" value="TF-1 CELL APOPTOSIS RELATED PROTEIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06840">
        <property type="entry name" value="PDC10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 10 dimerisation" evidence="7">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000085400.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30416" checksum="4BDCE747AED46ABB" modified="2015-12-09" version="1">MENVNYNKTNVERCSLEQTKTSLPSKQLSSPIDKDIFLPNNKLKMNEEGGHLDAMTYPCIFYPTLHKLEEELSGNGSAINAIKLLKKSFINAEQNSPSVLFDLSLVLLNEAKLNVNLQETYLRMHGSAPTFNFELENLKHIPEFQNLSDRAIELRKTLSRIPDQMMDRRAFLGTIREIAAAIKNLLEATNSVIQFAPPPCQQPIEKRKREFVHYSKRFSNTLRDYFRDQNAQQVSVAANQLIYQTNQIVRTVHDKVLKYQNHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B502</accession>
    <name>A0A0N5B502_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B502"/>
    <dbReference type="WBParaSite" id="SPAL_0000114800.1">
        <property type="protein sequence ID" value="SPAL_0000114800.1"/>
        <property type="gene ID" value="SPAL_0000114800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF164">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893768" evidence="1">
        <location>
            <begin position="20"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="280"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000114800.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="58567" checksum="530B312AF1A3837D" modified="2015-12-09" version="1">MNAFILVLYTYVLFVVSRGDSNNLIIHTYGIGKQIISEKLYSETASSSLHEYVDHDVNPCDNFYKFACGKWIRTQEKKYEYHTNFSIRDGNVNFDKVVLEFQQGKYKNESKIFNNLYNLHRKCNHLPSAEIFECRTEILNFGAYALSSIFIRKNKIKSEENGDYIYVEDMIKRIKKEFRLLIDEKKHIFDEETRNNFLYKLDKMKFKRNFDEYDLSNTKEMEYCYKKFKMFFEDDFSIKLVLKNIRSIKGSLDRKNDTLDSCFGKIFNPLLLLGKYVYANAWYRKTKNFFTFNSDVLNEPSFSAYYPMSLNYGYFGATISHEITHAFDNGNYNRTLEGDNRNNFNVTQMSVKNFEEKIKCFIEQYGMQKDSITNININGLQTLPENIADNGGLKLAHRAYMKWLQSNGGKDIEVPGFEKFTKEQLFFISYGRKKCEYTSKDMLEKKIKTTRYPPPEIRTNVALSNYKPFSDAFNCPVNSKMNPEDKCELWKIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B577</accession>
    <name>A0A0N5B577_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B577"/>
    <dbReference type="WBParaSite" id="SPAL_0000122400.1">
        <property type="protein sequence ID" value="SPAL_0000122400.1"/>
        <property type="gene ID" value="SPAL_0000122400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF3">
        <property type="entry name" value="I-BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000122400.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="32390" checksum="9E26B047F9948F19" modified="2015-12-09" version="1">MLLITQDFFLSNFNCSKNDVLEKICKFPPKSDSQKIEQMIEYPINVVRNIARKLSRSNYILIADFDHMFSENFEKKVLPMAEKYLGANSKNALVYRIFEINENATREPRNKEILEKMMNDSEAFIFHHYYPRGHNIPRLKQWFQVPDSETPKVQIEVLYMERAWEPQFISNRDIPFHDESFPYPVRDNTNLRWAMCRMDYHYLIMNDVFMYHRGLKAETENAIVKRARAKAWKHYINALMQFNQKMDTLFTDTKQKCPKLDLEYMRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6B3</accession>
    <name>A0A0N5B6B3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6B3"/>
    <dbReference type="STRING" id="174720.A0A0N5B6B3"/>
    <dbReference type="WBParaSite" id="SPAL_0000160200.1">
        <property type="protein sequence ID" value="SPAL_0000160200.1"/>
        <property type="gene ID" value="SPAL_0000160200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="376"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000160200.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="88696" checksum="A1B2A9836F9E5B2C" modified="2015-12-09" version="1">MRIRSFQPVSDPTQHIQSWDLLKKAITEILNQNNSGLSFEELYRNAYVMVLSKHGDKLYNGLKQTLENHVKQRVLQRLNDSWNDNFLGTLNKLWSEHSIAMHLIRDILMYMDRVYIPNSGHPGIYITGIQTFRKYVLEQPNVADNLSNIILSMVKSERNNEFIDKVALKDACKMLLHMGNSSDRSLYEQLFEKEFLKDTKIYYEHKSQKMLMDNSADLYVEKVQEILKKECEFAELYLDKVTEKKLMQDLNEVLVKNHIHTIINMENSGMLYLLKNDMLPQLANMYNLFKNVPTGIENTVKCLSQYVRETGEYYVNSFDKVGEDGQTIVTPVKLIENLIGLRDRCENFLINAFHRDEQIKRSLVEDFEYFVNLSRKTPEYLSLYIDDRLKKHLKEQEGDIEAATSKAMILFKYIVDKDMFETYYRKHLSRRLLNSKSALDYSEKHVVDKIKHECGGSFTSKMDGMFQDIESAQLIQTTYKEYCQNNPSSSGIDLTIRVLKPINWPSSIGEEVVNIPPELTSAFNHFNTFYTHKFKNRKLMLHWGLGNAELKVTFYNKSKNNDDKSQLENGNGGNSNTRKETKILIVSTTIMLMLLEFNKSERLSFKELKDSTKLPEKDLKRALMSVSMGKASQRILIRAVGTGKEIQHTDEFTINDNFTSKFAKIRITSVTGKTEVENENERKKTKEVLEGDRKAEIDAAIVRVMKARKSFNHNNLITEVTNVLCKRFRPEISTIKKCIEGLIERDFLKRNEKDNKTYEYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6C4</accession>
    <name>A0A0N5B6C4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel subfamily K member 18</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6C4"/>
    <dbReference type="STRING" id="174720.A0A0N5B6C4"/>
    <dbReference type="WBParaSite" id="SPAL_0000161400.1">
        <property type="protein sequence ID" value="SPAL_0000161400.1"/>
        <property type="gene ID" value="SPAL_0000161400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF240">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000161400.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="78223" checksum="48AAD41C30DFD6F4" modified="2015-12-09" version="1">MLSDTQKVHNIRRNINRIRKSFKSGATQLSTQIREEAIQSLQSVRKVPKWVQLLHKIYHEYGLKHICLILILVAYQFLGAAIFYFCEVSYDENKENTWIEDIKVNRTRLINDIIPSLFNNTEYLFFLTENQTKSVFWQLNKKLVDYEKQLGIKYTDQKIKWDFWNAMLYAQTICTTIGYGFTYTNTTLGKIATILYAILGIPLVLSVLDDFGKVLTKFLKYPWLQFKCGCRRAFRYFTKQTMEEIKKLDAEDKLYLEVFDMPIIVAIGIVVAWIFICSATFCIWERDWDYFVAFYFFFISLSTIGLGDIKPTQPKYLSILFIYIIIGLSLVSMCINLIQSKIEKTYELRSRSRTECSLQESNNFDPNNNNNNLLCIRNIRRGSSLGVFKSNEGSNYSLCREQIQSLLNNKRKINKGVQTLLSFPNYTCSTNIVQSVDQEHIKYVPKSLSIEDVMKLIGNDEGSIFLLSDGEHDDNNFNDDYENNKNDSENHIVISRSFDINFSPILNLDKYSIPLSTKIGNRMPTLHELEVIEEIEDNILLQNLIPKNDELPTFPQNLVHFRSRLSLIPEQKSIISDESSFTSNNDKTEDDTSDKEIESINEPVIKYPDSQPISSDGNNLSTSRSLSKFFKSIFYSNYSLNKSSSNVEDIRNKYDDEGNNTENSSSMTSLKVDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6G1</accession>
    <name>A0A0N5B6G1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abhydrolase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6G1"/>
    <dbReference type="STRING" id="174720.A0A0N5B6G1"/>
    <dbReference type="ESTHER" id="strea-a0a0n5b6g1">
        <property type="family name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000165100.1">
        <property type="protein sequence ID" value="SPAL_0000165100.1"/>
        <property type="gene ID" value="SPAL_0000165100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="96"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="257"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000165100.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42478" checksum="617B80D47F1603F8" modified="2015-12-09" version="1">MIFLPQVPKDICNRNVISVLEFVIRLGNEYLGSVVEAVGGPEKRNEWIRLLASSFIIFQATQPFKKHLKISTHTFGGTPCRVYTPMDKYKKTDACIIYVHGGAWCILKAHHFDYIMSAFVKNCGCTIISIDYTLAPDKIFPNSFNECWNAIEDICENFHESLEIDKGKIAIFGDSAGGNIAAALALKSSRTGKNYFKCQILVYPVTSCLDFQNSSYKEYYKEYNGTGLLNPEGMARWMLLYLGIPATKSNVKKVMKNQHISEQLKKDFMLKSECLNGCDKQLSEAFEIFARNPDFCPILSNDLHLLPKTLIITSGFDICRDEGIEYYEKLQKAGVNVEWKHFPTSFHGILNLAGSKTQKTVKRKINEFCEKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Z4</accession>
    <name>A0A0N5B6Z4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphorylase kinase</fullName>
            <ecNumber evidence="3">2.7.11.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + phosphorylase b = 2 ADP + phosphorylase a.</text>
            <dbReference type="EC" id="2.7.11.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.19" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Z4"/>
    <dbReference type="STRING" id="174720.A0A0N5B6Z4"/>
    <dbReference type="WBParaSite" id="SPAL_0000183100.1">
        <property type="protein sequence ID" value="SPAL_0000183100.1"/>
        <property type="gene ID" value="SPAL_0000183100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004689">
        <property type="term" value="F:phosphorylase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000138">
        <property type="entry name" value="Phosphorylase b kinase gamma catalytic chain, liver/testis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002291">
        <property type="entry name" value="Phosph_kin_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01049">
        <property type="entry name" value="PHOSPHBKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000183100.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47903" checksum="5E4638BA3DB048DF" modified="2015-12-09" version="1">MKDRHSKSASYDSDEDSDLVRDSIVVEHESGFNRYYEALEILGTGLASTVRKCIEKSSGTMYAVKIVDISTEKQSAYEATRLREETLSEIEILKRCSDHQSIIEMHDFFETPTFLFAVFELAPHGELFDLLNKSVRLSEKKVRNIMTQLFDGVAYLHSLNIVHRDLKLENILCINESRVVISDFGFAKQLKKGEKLRDLFGTPGYLAPETLKCQMYEDHPGYSLEVDNWALGVIMYTMLAGHAPFYHRKQLLMMRMIQEGKFEFLKDQWENVSVHAKDLISNLLVVDVEKRLTAGKALEHPFMTFEGTLKRRKSFRYGVVEEIIPPKKAKNLRQLFRVAILAAKFLHRIQNGSLFKTSYTREELRKRPYRSKAIWLEAEAATFAIYGHWVNRGFFYSRDMLFANKPKPKMVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B751</accession>
    <name>A0A0N5B751_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B751"/>
    <dbReference type="WBParaSite" id="SPAL_0000187900.1">
        <property type="protein sequence ID" value="SPAL_0000187900.1"/>
        <property type="gene ID" value="SPAL_0000187900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000187900.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25729" checksum="16DF22DAAF117105" modified="2015-12-09" version="1">MATNSDIKEDPLSPSKTSDFSILNDDTLADLLKKQLTIPQMQFFGGTPFTEYVDKNAVFFSKLENLKENEKTAYLLGCLSDEVYRLLKLSRPNTALASCKYSELVDDLTKFYTETIKYAKEYTNLLLPNSHYSDNRTLHMIKKVEWKSLEELTSQKIPDLVKVIILFDHYKEPVKSIAERYIQEHHDNLNLSEFITHMETESLFINENSDGKKCRRKKLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7E2</accession>
    <name>A0A0N5B7E2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7E2"/>
    <dbReference type="WBParaSite" id="SPAL_0000196800.1">
        <property type="protein sequence ID" value="SPAL_0000196800.1"/>
        <property type="gene ID" value="SPAL_0000196800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000196800.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16116" checksum="75F39C9076BAC60C" modified="2015-12-09" version="1">MVHHNNIVPTYLSSSSSLSPTQSNTNIPKNPTQHNLDEKKGIGEGMITSFRGSQEPQSTSDFVTHNIASNFTTNLSNTFGVSLLLKPFRKTQKEGNAKKSIKWSGSVDVPTEPNLSFIDNLLDQAINEVEISRHVNISLPAQLIVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8H0</accession>
    <name>A0A0N5B8H0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B8H0"/>
    <dbReference type="WBParaSite" id="SPAL_0000234300.1">
        <property type="protein sequence ID" value="SPAL_0000234300.1"/>
        <property type="gene ID" value="SPAL_0000234300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="821"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000234300.1"/>
        </source>
    </evidence>
    <sequence length="1434" mass="166643" checksum="6720E3D63AD7A1DC" modified="2015-12-09" version="1">MDDSINIQNGQSFDIDNSNNSQWQLDGNANGIRIEKLDYKIGELSAELMDEKRKNRKAYDYLCRLSEVRTWIGEILNEEDIPAPIDLEANLSNGVLLARIGNKISQTEVPLSKIYDIDQLKHKKEGLHYRHTDNIMLWRNSLTYVKFPEIIIPETVDVYQGKNCGTIYCLYTLAVYLFRLRKGPPIKNQSGSIEFRQCDIDKMKERLGDMNLPSFHNVDDILSNRFETDRKERARIVLLINQLLEESSEIKTEELKSLLTNTDGDFLFFKEDYIISYWNSLLAAKGTDGNILSHEDIQLVINDVNDGENLSNLNKYLLGSTDLNNLKVILYELYGEKVTESVTKLYDTLLREKRLEKDGDLNLEEVLEIILLGNACMKVKLCVTQGSVEDVYEALSDESLKLVDYINNNAKNIYYIGLTNEIHNDDNVMGPNELKTFIIKMNNLSNKDLKVMEMIEKLRNGENSDKLEIMFRDLEIEETKDEYLLLYFSTISKESSIRFVDYNDVVNIVNDINSKANEAKKNGQELWLINSALRNEEPYKLIEVLKSTHWYSDGVVRDHVLNWYPATFDKAIAEKGIDVNKELKWIKYETDVGVFYINDSDFSLGPQEVFEDNYITELDVEEIIEATNNGFDDYYKINENSIIKGQKVIRKHLENKANIRDIEERTKAAKIIQDNFRKYRRKQNLDTLQNCSDPPLSLVRKFVDLLRHTDLDFEEELTAERAKSHVTRLITSNRNMDLDLDELDHKIGLLVRHRISLEEVMAHKNKVANKISTYLNVQVSTKRKEKIQLNVLQQLIFHLQTEPHYLSNLYFTSDDENLYEKALLPLFNFVSEKREEFLFVRLCREILKEYIDSLNDPKKFININDQNGYKLVKLLRSFFQTLPSYDVLGISIKDVHASYHSADHSLRINLNPTCMFEEKYKRTPTDIYEALADDDILKVLNESKNFIIQWSKEFANQLLSNLSLPKSVRYLMKVTQVELRNKFANLSSNKVSSMVSFFLWKCYIEPALVDGKIFKRESGLNFTDDQSERLNMISKLIGYASMGKSYGSQEPHLFSLNDTIVEIHKKFLDLANDSLENINLDNIYEITQYSSILSSQKPTLYIALENLKYLVNLLKKNKESVFDESGSRLKKLFETIDIVYDEEKIGDHLTLSLSAMPPEEVSPSIDSKELFVQTKRYFIDLLLCGVYGDTVPEVLSTKINEQHEEVYTNIIKNSDDNFASLEEKKEKICENLISLANVGIVSRNNDYQTLVNQIADEIIRQGEYRQNRAKQINHFQETIKRLEDKRKDYEDRLEKYKLFLDSCLENMKKNSLKPRIKSESHRASKLLNDREKLLNPKSIKVNGEKMLKKEILKSSIFSAKELSKFNFELNFTGKIDQFEVVVKKPKVDPVTVFINFQELLEHEYNQTISIPITDEISFNVGPLIGYINKKFYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8M4</accession>
    <name>A0A0N5B8M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated protein Hem</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEM-1/HEM-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8M4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8M4"/>
    <dbReference type="WBParaSite" id="SPAL_0000239700.1">
        <property type="protein sequence ID" value="SPAL_0000239700.1"/>
        <property type="gene ID" value="SPAL_0000239700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN HEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000239700.1"/>
        </source>
    </evidence>
    <sequence length="1138" mass="131679" checksum="E4A65416CAD997F6" modified="2015-12-09" version="1">MANISPLKFAEKLTILNSRTIGLLTRLYNIKKACFDPKLRPKFLYEKTIEGAVKLLLKKFPLSDLKNNQSVFDTVRKQKTEIMKSLSLYYFTFVDVLDLKDHIMELLTKMNMVCRKFDLTLNFELTKVYLDLVTNYCSLMILMSRIDDKKAVLSMYNLCHEMTNNCNESSFPRMGQMIVDFENPYKKLNEDLTPINRLMHSSLVSLSKIYLHRNIHADVWRGAQMLSLTTNSSQMLYLAQTETINCEFLSIDTMERWIVLLTIACHGVLLNDPIIVGMWQRTLQTSLVVPLFRDEIINLHNVFIECFEGTKGSSKKINEVKENYNITIQTSNSIHLERRRFLREALKDLTLLYDDQPGILGPKILFALIGLCFARDEINWYVRHLKEWPQNTKKHKSQNFMVDRQISELIYYTLQLRTIVEKYDRIVSNYYFKYLKSYDAFVMQECIMEIGNCLAKDDEVRLHSIHASMQENIKPTYETYQDVKLDWFRIQANASVEKYGINLEDYRKLCILLNTSCWHFELIGNLKTLLMKCSSLDIYAFYQEQLKEQFDEARNSHYFSRYAISFAKLTGDFECLLHEMCPEEHDTIIDRAIRHSTMFLEDIGKRLCTVSLSMISEEYDLNCQASATRCADLIDITNRAQNGKGNRVPEIVPMPGHESVRISRDQLTSMDKQLSILTDLINAVTSWDSFYVFDSILVPRDYVLRYYDKSLITIFSLKFFVDQEKKIISRPSDLVKFINSELTVLHYVERCLGIDLQRLFTSVLNQESLTIDVYNNETFTSLYIKFYVASILKKASTGNVHFSMITSTFSSTPDYEGPPPEHYTDPSELMALATLIGPFGIKNICDHIMWQCAAQIMELLRLTTQNKQILCEARRVYTHPGKIKDILDKLGDHDTEIKKKAPQNQTNQTVHFFTNRLTIVGILMSFKKMLLFSAKNVFKKRLKFLHSCSENIMNEFNDEAKVKAHELFSTLVVEENDYSILVSMIEQDYDSLNVKDGNEFHLICSLLMVFAAITLPRLSAQTQSMLKISTHSTSNNINAIPVALDTISNVLFAICGRLDCGERMKEFLKIMSCGLLQIVGSSASEQCLNLRTLNVLLEDIVNESKWITFDDLQEVFPHNLIASSYTSCFINEKTSVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B936</accession>
    <name>A0A0N5B936_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B936"/>
    <dbReference type="WBParaSite" id="SPAL_0000255300.1">
        <property type="protein sequence ID" value="SPAL_0000255300.1"/>
        <property type="gene ID" value="SPAL_0000255300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000255300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15650" checksum="1D92BDD5968B6795" modified="2015-12-09" version="1">MRVVLCLEATVLTTVPSGFVGSTLPLKTDFALRIVICPDLIPVTDLLFCKLSALKLFEFFGTTFICTILSLLEVLNDSDTIPPFFLFTQHCLFFLMIIQIRMAIMTRITADIAPPIMYPFLLESGMGSGIESSTIFSDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B987</accession>
    <name>A0A0N5B987_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B987"/>
    <dbReference type="WBParaSite" id="SPAL_0000260300.1">
        <property type="protein sequence ID" value="SPAL_0000260300.1"/>
        <property type="gene ID" value="SPAL_0000260300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000260300.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37650" checksum="0B8F838CD3028B2D" modified="2015-12-09" version="1">MDSNETANFEEYTLNPELALDGEYVYNNTCQFIYKSDILTNVQIGMLYFIISLFLLILQLLTCWSFHKISKSKSNSTYTIMKHQGYLAIISLLSHLTTSIITILNIQYNVYFEAIVGACLQCSYFGCITLIVLVTFNRFDVMYNIDLFSKIPRDKLFLYGIILCYLISLPFGIFYTIPRYRLVFCFTIYEWYCQGLNPATYIVCDIQNKMVLIMLSIAFILHVLIFIKIICLRCYTSKKNLLALQDIKFVIYAVLCFATVAILELMWNEVLSFIYFSDIGSMFPPTLYIIVSGSNAIFTICCVNEIRRNVFWCVGKIKGSRVTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9I0</accession>
    <name>A0A0N5B9I0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Exocyst complex component 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exocyst complex component Exo70</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9I0"/>
    <dbReference type="STRING" id="174720.A0A0N5B9I0"/>
    <dbReference type="WBParaSite" id="SPAL_0000269600.1">
        <property type="protein sequence ID" value="SPAL_0000269600.1"/>
        <property type="gene ID" value="SPAL_0000269600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="303"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000269600.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="72253" checksum="F9554485E964D4BC" modified="2015-12-09" version="1">MMNFTPPTDGLSAAELTKRLQRDQEWIESVKGSLEKSKVINDSICKLIDKFNDRVGYLEKTVMPLCLKTDTVQRRQQNVNSLLNLIDTTMQFYEKTSDMEEVLKPGTAVNNLDEFLKKMDNIISAIHFFSTQETYEEELRKLKDYHDGGLSTLENDFITIVNAETIKLEPEEVLSNLDEENEPISTSHSSLKSLRNVQKVGKCCKWLLKNSKNTMCLNNYTSLRSQTLYRTINDLLIHISSNTNVKLNVSGGLLNLTQPKTQRSGGLRSALRKIAKGSESEKVDVIDDYRDTSYEYIAQLFSSLIMLLEIEADIASQVIGNVKYEASVQRAIVTKPMIFLLDQLTSILDSSETNFLSLIPVCKFFQRHHNQLASLSENAEGDHIPYNRVYNTLNSTCSSSIREYVDRLQNDSTKTVPLDGNVHQITANTISILKALLQQKQIISNILAISSHYEKNHVPRLFAEVLSALGKNLKNKCQSYQDESLSAIFMLNNYNYIAKRLQDPAMSAIMKDDINLTSFYQMEIANCVEKYLVSWQRVSSIVSQSLVDIDKRQLKSIYNTFEKELEQILEAQKNYVVADGAYAYLIKSRIKEMILKNHERFYAIMTESIGGDKNFKYDALSIEVVIDELFDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB01</accession>
    <name>A0A0N5BB01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB01"/>
    <dbReference type="STRING" id="174720.A0A0N5BB01"/>
    <dbReference type="WBParaSite" id="SPAL_0000321500.1">
        <property type="protein sequence ID" value="SPAL_0000321500.1"/>
        <property type="gene ID" value="SPAL_0000321500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF37">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000321500.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29575" checksum="4FF38F1A01AF2EA3" modified="2015-12-09" version="1">MLVFEIYSGIRIFTKNSGMERSRCLHIIFLHLFSSAMAKWLMLATGIDRLIAILRPINHNFWSNTVYSIVISLPGLLFALAMVVIGFVTIDDEKLNFCNPVSVLIINVRIIYRFIVIGISIITIILYSLTFIILFVHTKKSFKNDHLMFTIHKEMAISLALNALFFVISTFLGYLVMCLVQIFSFSRTTMDAFDALMGLPILITSSCTYYLLFWRAHQYRALFKRQLRCRNKLEDKNVKSTRLSHKKYGQTRVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBB6</accession>
    <name>A0A0N5BBB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBB6"/>
    <dbReference type="STRING" id="174720.A0A0N5BBB6"/>
    <dbReference type="WBParaSite" id="SPAL_0000332525.1">
        <property type="protein sequence ID" value="SPAL_0000332525.1"/>
        <property type="gene ID" value="SPAL_0000332525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF2">
        <property type="entry name" value="PROTEIN RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="138"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000332525.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33075" checksum="D26E72256017F8C7" modified="2015-12-09" version="1">MKIESDLNKEPFLSLIEKSCTVTYNVKNEKIQIDDEIIFMGVNENNNSNVINNEINNDFLIIPKYYRRYFKISTAFAFIRKKYCQMIAYKNERSLCFPLFISSIIITTGILLANSSKSSVYDNYLKLLPASENRYSILWRLLTYSLLHSDFFHWVMNIILLFLIGTPLELKHGWKRISFIYTVGVICGGLAHLIHDPKNSLIGCSAGVCTILMFNILNLFTNWKEMNKIYRKVNFIITTVIVFLEIFNIYNNYEHNLNEISYSSHLGGVISAIFTGILVLKINISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBB8</accession>
    <name>A0A0N5BBB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000332700.1">
        <property type="protein sequence ID" value="SPAL_0000332700.1"/>
        <property type="gene ID" value="SPAL_0000332700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF164">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="130"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000332700.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="35155" checksum="13EBEFD00D54984C" modified="2015-12-09" version="1">XLKKNKIKSELNGDYNVIEDMIVRIKEELKLLIDEKKDIFDEETRKHFLHKLTTMKFKKNFDHYDLSNIKAMDSCYENVDFIFKYNNPKNAIKTIKKIRERSFRHDDDLNYCRGKIFQTNKYLDDYIYSNAFYNSTGNYFSINSDYLNEPSFSKNFPMSLNYGYLGVTIAHEMLHTFDSVNYNRTLYDDYESIFNVTQISVENSKEKSKCFVRQYGMQKESITNKNINGLRTLNLNIADNGGLKNAHRAYMKYLQSIDNIDLIVLGLGKYTKEQLFFINYGKKRCEYKVRTNRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCC8</accession>
    <name>A0A0N5BCC8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 18">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="12">IMP dehydrogenase</shortName>
            <shortName evidence="12">IMPD</shortName>
            <shortName evidence="12">IMPDH</shortName>
            <ecNumber evidence="12 18">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12 18">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 18">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 17">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="12 18"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCC8"/>
    <dbReference type="STRING" id="174720.A0A0N5BCC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000367700.1">
        <property type="protein sequence ID" value="SPAL_0000367700.1"/>
        <property type="gene ID" value="SPAL_0000367700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000086">
        <property type="entry name" value="IMP dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0129">CBS domain</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12 18" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 12 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 12 18" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="19">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="19">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="12 13">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12 13">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="370"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="393"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000367700.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="57262" checksum="E72257E43D30EE03" modified="2015-12-09" version="1">MDSDMFVPENEEVFDVESDGLTIKELFEVQNGLTYNDILMLPNFVNFPLSEVKMNTQFTRLIHLKTPFISSPMDTVTEAEMAIGMALQGGIGIIHGNFSSPEGQLQEVLKVKRYKQGFITEPQCVKPTDTVQDLLRIKVKYGFTGTPVTSTGAVGGKLLGLVTSRDIDFLPEKDAPNTFIKDIMVPIERLITGSEGLKIEEAYKTLEQEKKSKLPIINSSGELTALIARTDLKKARDFPLSSYDHKGRLMVGAAVNTRDGSIDQIDRLAKAGVDVIVIDSSNGSSVYQVNLIKEIKKRYPKWPQVVAGNVVTMKQAKILIDAGADALRVGMGSGSICITQEVCAVGRAQGTAVYNVARYAKYRRIPIIADGGIRDVGCITKALSLGANTVMMGGLLAGATEAPGEYFWSPSGVRLKKYRGMGSIDAMEANAAARDRYYANEKDKIRVAQGVSATMRDRGSLHTFIPFLYMGCKVSLHNCGVKTIYDLHKGVYEGTVKFERRTASSMQEGAPHSLYSYEKKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCD6</accession>
    <name>A0A0N5BCD6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DBD_Tnp_Mut domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCD6"/>
    <dbReference type="WBParaSite" id="SPAL_0000368500.1">
        <property type="protein sequence ID" value="SPAL_0000368500.1"/>
        <property type="gene ID" value="SPAL_0000368500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000368500.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31495" checksum="AD3F83DBCDE5B183" modified="2015-12-09" version="1">MYGYPTFDITFEDLEKIQSLSKKLHCAMKFTGSQLVNVSMFKKWLLIYKEQLNIKEGEIESTVEDDTPYGWSSITNYMVNHLIFIPVGEVQEWNDVYFYEEFVVLKKVTIYDFKFDDSCCTAAIDKCEAKEIIRMGVDAYNMIKRPEILEIQKRYYNEPEDEVLEEEDDLINYGDGPTQEDFDSIPQEINDGPFDSDDENMNSPLPEKKEIIVSDEVMHEEVVSLFYECNIVAKAFIQLKRSSNESKRLCPIIPHIHLTNHSRNRPFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE96</accession>
    <name>A0A0N5BE96_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE96"/>
    <dbReference type="WBParaSite" id="SPAL_0000431900.1">
        <property type="protein sequence ID" value="SPAL_0000431900.1"/>
        <property type="gene ID" value="SPAL_0000431900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="523"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000431900.1"/>
        </source>
    </evidence>
    <sequence length="747" mass="87537" checksum="8ACEF9859B2DB9DF" modified="2015-12-09" version="1">MFMVTIPLFFEILCYDESSYFERYPSTIRINVSEYPIMRRNLSTVETIHGVNIDDPYRYLEDIYSQETLHFIKQINTMSDSVFKKSKYRNVMKEKLQEYMNFDKYGLYTKLGDYYYYYYTPKGKENYYLYRKKTLNSKGKLFFKYNQTHGNTSIYYNYEKFSEDGSIYAYGFTNESTQLTTINFKLSNGKILKDSLKDILYTDIAFIFNNNGVIYSTFSNITHLETEEYSYIIYKNHSLYYHKMSTPQSEDIIIADNPINNTFFMYGYVSADEKYLFANIYPQFDSKNTIYFYDLRNINNNRFNGKINMRPLIGNFDANYQIVDSNSEEAIILTDKDAPMRKIIKIKFYKSFLGEKSWKILIDEEKTRLIEDVTVVGKDYLILRCLENVRSILHIYNKHDGTLLQTIDMGLGNIEHISGNRRSNEFFLYFVNPIIPGIMYKGDLNKMKNNGKVKFKKLITELPNSLKIDDLSIKQIFYETKDGKNVSMFLLYKNNIKLNGNNPVLFEAYGGFNISYTPYYHASRTMFVKHFGGIWCLANVRGGNEFGDEWHKEGILSKKNNTFNDVIDGLNFLISNGYTRPSKLGIIGTSNGGMVMAVVSQRRPDLFGAAVIEAAPLDMIRFHLFTHGMTWRDDYGDPNVKEDFDNLLTYSPYYNLKMPSQPLQWPSTLLFTTFYDEIVVPIHTLKYTARLYEILQKGIDYQYNPIIATVIMNRSEHGEGTSYHNYIEDNVKIFSFLQQALNLTWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEP9</accession>
    <name>A0A0N5BEP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000447300.1">
        <property type="protein sequence ID" value="SPAL_0000447300.1"/>
        <property type="gene ID" value="SPAL_0000447300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000447300.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20810" checksum="2698046C0EEC6A4A" modified="2015-12-09" version="1">MDFGAKLIASAMSKGYNMEVSPIESIKTENTDVQQRGMFLEDICDATGEIDLNKLLKQIKACNPQDSPTLNEHMPLIFTLAYKYGCLKKRMKGGVRCFSKEKIELPVLQQYDEKNPREFLDKFRMRYGSLETTSQHQLFKEYLSGSALIAYKALKIEDYNSFKEFTEAWIEHYKPNFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF57</accession>
    <name>A0A0N5BF57_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NNMT/PNMT/TEMT family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF57"/>
    <dbReference type="STRING" id="174720.A0A0N5BF57"/>
    <dbReference type="WBParaSite" id="SPAL_0000462500.1">
        <property type="protein sequence ID" value="SPAL_0000462500.1"/>
        <property type="gene ID" value="SPAL_0000462500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF39">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000462500.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33243" checksum="00DC2FAAF97A627F" modified="2015-12-09" version="1">MDDIVVRKQNISTSSSDSGIDSKLHDDDKPISYDPPRSELLDRRTIARDFSTEAYLNDFYSNVDDCAMQMVLNYLPQFAARIGKKDRLLDFGAGPTIHVPCCFRNYVDEFFLSDYLPQNRKELLNWFNNTSTFDWSKPLKMIANCEMGDLTKLKEMENLAKSKVVKAIIHCDAFRDPSINCDPSYRKSFDIITSLFCLEYCTETNEEFKNCIKNVLKQLKVGGYYIMGGVMEENWCSFNNKKFVCLYLTEDVLFDALRDAGMDVDNEKETKFINDNGMYMILTKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFC7</accession>
    <name>A0A0N5BFC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Helicase POLQ-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFC7"/>
    <dbReference type="STRING" id="174720.A0A0N5BFC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000469400.1">
        <property type="protein sequence ID" value="SPAL_0000469400.1"/>
        <property type="gene ID" value="SPAL_0000469400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="147"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="367"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000469400.1"/>
        </source>
    </evidence>
    <sequence length="819" mass="93101" checksum="6D1AE00C9096CBB0" modified="2015-12-09" version="1">MSNHSDTSNQIGGSKPVCFVKSWQILGLDLDIENNDIVSTRKRKLPPPLNQSNIVTKFKNVDGRLMECSQKAVNEFTSPCVNNSLSSYLSWSPEHQIYSLANLNNIKDLSDKDVFSKLELPSQLYEYYLNERNISNLYDWQKECLCDIRLLRGSNIILSLPTGAGKTMVAELLMLREVINNKKSCIIVLPYVAIVQEKMNSLMEFKKMFDIEVLDYAAGKGAIPPVKSAKDCGTIYVATIEKANILVNSLIANKRINEIGLVVVDELHMIGESMRGVFIEQMITKYLMSLSGQIIGMSATLDDMTCLKKFMKAHVLSVDFRPVRLDQKVKILNKMYYLDEREGQGKLVPVPGGMDNNLHDDPRDFGGILPFLKPIIPNQGVLIFCPTKESCENLCGTLSEILSEDPVCADGDLRKEELIEMIRNDNGGRICEIMEYGILAGVCYHHSGITVEERDRIETAFKSGIIHTLCATSTLAAGVNLPARRVIVKDPFMFDEVYTKSQYTQMVGRAGRAGLNSYGDSITIITSRKKEKQFREMIESSYAKCRSQMVKGSSDYKNFQILLLDMICLSMAKTRKDLEKIMYCTLYGYEHREDVIKVLNCVIAKLLEFKMIKIECDIYAATPLGLATQSANFSPGEAVKIKQELDYHLENGVILSSVHHWIYILLKNDISLKIKENKLHNEMEYLERGDPQMFSKISDVSYPQLVAEIASQHRLKPKFAKIYAFLMIRRLLKGESIWDVAKEFSVQRGSLQNVLQSFYTHARCIIRFSEKIPELWSVCHLSPHVIKRLFDSIFPTLESLRFVKMVDETVYDEFLQMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFX4</accession>
    <name>A0A0N5BFX4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHYHIP_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFX4"/>
    <dbReference type="WBParaSite" id="SPAL_0000488400.1">
        <property type="protein sequence ID" value="SPAL_0000488400.1"/>
        <property type="gene ID" value="SPAL_0000488400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042868">
        <property type="entry name" value="PHYHIP/PHYHIPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045545">
        <property type="entry name" value="PHYIP/PHIPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698:SF4">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698">
        <property type="entry name" value="PROTEIN CBG15099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19281">
        <property type="entry name" value="PHYHIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytanoyl-CoA hydroxylase-interacting protein-like C-terminal" evidence="1">
        <location>
            <begin position="127"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000488400.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40420" checksum="AD42287D731CCC43" modified="2015-12-09" version="1">MEIHKNYHGMLNSNYNDYDSKFAPDKYGCIERPLTIIQNDNYTITIKLDEIENEFPNSVKLMKIVEERFYAETSENSNIIHDQDEITLPVSPGVKYWYRIYAPVYIGVQIIYVYQSYYECILTKTNIKRLFTKSCEIFAKIKKEDTQIHQLYRCKPKSYFDKIEELNNGIMCPYPKDNTGHPGNPITGKVRGLFFSGKYYNGSEFPRNNPYGDTRFVIEAHKLLNPNIHNYYFSDMYCAKSDNTHMLTIVVCKKDTPEDKFCKKHLVYLPSKDNEFMYCIPEDNTYTYYWNWCVKNKIIMNFEVFYCGEVSIYDGEMMDVPCVTGRGKTTPGGIGHNAKCKICNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI21</accession>
    <name>A0A0N5BI21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI21"/>
    <dbReference type="STRING" id="174720.A0A0N5BI21"/>
    <dbReference type="WBParaSite" id="SPAL_0000560600.1">
        <property type="protein sequence ID" value="SPAL_0000560600.1"/>
        <property type="gene ID" value="SPAL_0000560600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000560600.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22260" checksum="E76DC1654D0D2094" modified="2015-12-09" version="1">MNHSLLTPWTSVSNLVGSLQVGDLIEIRKYANDGTPINNHWAVYTGLSNGHHTVGVFFNQNNGNNNQNLLKAIFSPDSNRDRTKASICYCYLFHVCGNDQCRINNSMDRHCKPLPSGVIYKRVIKRVGDCGYNTLFKNSEHFAKYARYNVYISEHANIGKIIEIGMNTLLVSKNLLKASTTGALGYVSLKVYDKVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIS7</accession>
    <name>A0A0N5BIS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000585700.1">
        <property type="protein sequence ID" value="SPAL_0000585700.1"/>
        <property type="gene ID" value="SPAL_0000585700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000585700.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10002" checksum="677BCE76C6AB65C4" modified="2015-12-09" version="1">MVNEVNVLSKIPGATGYMIINDGELIRSGGDLEGNLYKADIIMKLLSTCSGHHLTAINEKWNCLTIEFENALYGITVSSSMKNTVVIKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIT6</accession>
    <name>A0A0N5BIT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KCTD3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BIT6"/>
    <dbReference type="WBParaSite" id="SPAL_0000586600.1">
        <property type="protein sequence ID" value="SPAL_0000586600.1"/>
        <property type="gene ID" value="SPAL_0000586600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="143"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000586600.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="83179" checksum="8C89F28F9943CE41" modified="2015-12-09" version="1">MSHIVKVICNDITKLTVDVIVNAANKKLCGGGGVDGAIHRAAGKALLEECRKLNGCETGEVKATKAYNLVNVKAIYHTVGPIVRGTLRDTDKELLSKCYFNALHLAVKEGYHSIAFPSISTGVYGFPFEESVHMLSSSPSQNDVIRLNVGGTVFVTSKTTLTWLPDTFFTSLLSGRIDSVKDKDGSIFIDRDPLLFRIILNYLRTKHVDIENVDLSSLKHEALYYNITPLVRRLTLCEDSMNDCCGGLLFHGMISSKNEPFLSKPISVHTSSSGSSGNNLPARIIKAHHSYIAVAYTNYIRIFKQNDSVGWQKVFTSTLLNSLVVHLALNVKFGAQNLEKVVAASLEDNSVYLWSFTEDNGEIRSKKLGIFQMTAPIVKLFFIGSQLVALSKTGKVGIWHSISQSWQIQNIVPILCYDTAGSMLIFGGCNGVIYLVDMQKFPLRMKDNDLLVTELYKDPENEAITAISVYLTSKTTMSGNWIEIAYGTETGKIRVIVQHPETVGHGPQLFKTYTVHTDPVIKILMTTNHLISMCSCYNHVRTWNVSRFRGMISTQPASTALASFKILVLDSVDEISNSEGVDIGPYGDQDMESLFVQKVVPETNKLFIRLASTGERLCEVTSIDNSTITSFFIHEIELSNRMALRPKRILFTGHSNSTIQMWDMTTAFDQFTNKQLSNTNSGVISQTVLVPNDKSASPSTPSTTHKTFTSPHQGPSPSELLKLMDECEITADSMNSTPKSTPYASQINIASNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ46</accession>
    <name>A0A0N5BJ46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aamy domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ46"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ46"/>
    <dbReference type="WBParaSite" id="SPAL_0000597100.1">
        <property type="protein sequence ID" value="SPAL_0000597100.1"/>
        <property type="gene ID" value="SPAL_0000597100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="2">
        <location>
            <begin position="109"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000597100.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62062" checksum="7B3DEEF44293FF48" modified="2015-12-09" version="1">MAANESLMSSGSETFSKDNNPELGSVKFVPCDGDVEVSIPTKIIGLTKEQLEEYRNDPFWKYIRFFSFILFWIIWAAMFIGAILIVVLSPKCARNTNAQSWYENSISYQLFVPTFYDSDGDGVGDYKGVSQKLHYLRKIGVDSIWPGPIIKTDKDDFDVTDVVDFDKIDERFGDEESLKQLIADTHYENIKFIADIPLSVGMKSNWMIEAQKNGSNKYKEYFSDINNGILNLSNRDVNEKLLSVVKKFTDFGADGVYIRNPKNIDGESVGKLVKSIKQNTPKEFVVYTDKSIKEETPETYFIYPIFTKSCSLKNLPKCIYSNVNSGINNQTSKKVMWSLLENESERLDGRIGQETEKTVNLLTMLQLILPGSLKINYGDEYGLQTSQSPNAKQMPIMSWNNDNHNGFSTAEGGLIFGKAKNADKVNAYDSLHKMGGMSRIFQKMTKLKEREDILKIGTTDVILENGILYVYRYLKDTAGKIYILALNLNTPSTPEKTLRVEDKFLVDKELIQVITTSYGLDDPIPRENIDIKTGSITLKSMEGILLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJA7</accession>
    <name>A0A0N5BJA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000603375.1">
        <property type="protein sequence ID" value="SPAL_0000603375.1"/>
        <property type="gene ID" value="SPAL_0000603375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000603375.1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7396" checksum="46C4E83D6D3A3194" modified="2015-12-09" version="1">MDQIEKYCLNSVSCMLMFNRLVSLIKDFIQVVNNSTFQVDAVNINTENILDNKSDVLELKINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJT9</accession>
    <name>A0A0N5BJT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJT9"/>
    <dbReference type="STRING" id="174720.A0A0N5BJT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000620800.1">
        <property type="protein sequence ID" value="SPAL_0000620800.1"/>
        <property type="gene ID" value="SPAL_0000620800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF7">
        <property type="entry name" value="CROSSVEINLESS C, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="533"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="812"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000620800.1"/>
        </source>
    </evidence>
    <sequence length="1014" mass="115705" checksum="A224200F0AA1C35D" modified="2015-12-09" version="1">MNERKFHFYGTTNQQQNIKIVPFEYMLKGSPSSEECTNKKKNEKKIDVIYDDVPSTSSLLSISPTNNIKTPNEDKNFSSSINERKIEKFMSSMLINAKELCSIDQYQDSVKESKDNSNLRYFNKNYNQTEMGNRHNKSGVEKNSEDKIKDDKIVDEKNVITTSRKLNLGSPLSNSDSHIIYQPTYNINNGKKSLITNSTTSGDSPTLSSSSSIVSTTDYHNYSREQANEPPKKIILKGNNTHSIGDGKVEVSSNKLIPNNYNIIKIDGYSNQNLYNNNIQVEKKNKKEKDNHYIKEGEYSQSSSILLQSSSLSSDHHQPTTNKDKNNSISDKLIMKDKDKNFSSNLVKSSTIISVNPLRSLIVNDDGYYSHSPDPTKKYSNNRKNPSMTLKNSLTYHHSFFSPVKSNRSGYGSQLIDRQSSWLPNVTRISTSIISDSSDDGGKLDETILDDDTHVHRNLLYQTAINIDFLVDSTSSCLFGLLDKHSTSRLNNTKKIGVLGSNIRRFFSSSKHTSKNGDITFYRTSKVPSCFGMSLSDVQGYCEGEVLPKCIFEIMKFLLNHASTTDGIFRKSGVRSRIEKLKSQCIVKFPNERVFYKDNGECLLTMTQVHDVADTMKQYFREIPGKLFSEKISDFLICIANGLPSDKQIEALRYVILLMEDTNRYAALALFSFLNRISSWASENNMSAENLAVCFTPSLFNLNTESDKGTNSMSNLRLKRRKTIAMPSEQELMEYQGAQKSLALLIKHYEHLFNLPTDLHRQLKVRSPFFNFGCYNEPTININNITDIDIKECQNQIRGLVYEIVNDYGLDWNTWIPDCCYRDIAIYRKPVERCKFHFIRASFTVGVSPHEMWKVLSKNRKAWEKNVDYTSSVFVINNESDIQLISYKNYDERQEFSKKCLLFRTWKKDSPELRGGVVLIERSVEDKEFTHSNGHNIFPEVTCSCFLIMPSGNGSSKVNYIHRADVKGRGDLYYSKVYPKVITQKMVNLKNYFNITSSARNPSNGPVKGKETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK38</accession>
    <name>A0A0N5BK38_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK38"/>
    <dbReference type="WBParaSite" id="SPAL_0000630300.1">
        <property type="protein sequence ID" value="SPAL_0000630300.1"/>
        <property type="gene ID" value="SPAL_0000630300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000630300.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28380" checksum="F7962A36DDEBDA79" modified="2015-12-09" version="1">MERLSLKNFDNFPEGNHEIVLNHYDDFKMHKDIIDRIGQLGYTLTPSKLTYQINIALHGEEKRNVRLFGNDNENFFMYYFPLIFDRSHELHPEVPEKKIPLMVFVTLSPEAAAELYNTINTFVRSMKIHVVISHQGRKMEMNTREMRSPFHILVTTVSNLHHHVTKGMIRFDNCFYLVLVNIGLWKQSIDYVNLTDEMIKCGWDPVNKCSVIATSEKLDDTTKEVYSYFSFRKHYDFNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL27</accession>
    <name>A0A0N5BL27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL27"/>
    <dbReference type="WBParaSite" id="SPAL_0000662900.1">
        <property type="protein sequence ID" value="SPAL_0000662900.1"/>
        <property type="gene ID" value="SPAL_0000662900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000662900.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28278" checksum="9B9A4686711D44EF" modified="2015-12-09" version="1">MYANYLRVLGSGLEEKDFYRVILDNVPEDFRAEIVRDAMEKPDGLMMDPEYLLGIVERCCAEREELEPILLSVDRLMTLKFKEGKNAYTNLLNEITLRSHFIGNKEIKEYVIVMLFMFLLPTKDKVDVDSNKLWTLAKAKEYAVKADVTDKYKYSIKKKDIPKSEAQSSTEKEEKEAVKREVSNKRLFVEEEACQAEAFIDGVGKVTCHLDSGAGANSIGVSYVTQSILDDLKKDDIVVFKDAHGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLR5</accession>
    <name>A0A0N5BLR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLR5"/>
    <dbReference type="WBParaSite" id="SPAL_0000686100.1">
        <property type="protein sequence ID" value="SPAL_0000686100.1"/>
        <property type="gene ID" value="SPAL_0000686100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="152"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000686100.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49896" checksum="1AC89D1EF2B87F09" modified="2015-12-09" version="1">MTAPEFFCKKDYGSKYFIGGKITHQWIVECLEKNDDDFRSHRSDSKVKEINGVDISDGKGFLSKVFKTSIYFDDDKKAPYYVVLKIPGDESFKESMKKQNADESMNIELNFISEFHNKECHFYNNVASKIKDLKFPKCYGSKDLIVGEQAGALLMKFLGSDSVNVPFYRSLNIYQTKSVLNEVYKLQEYSLLNQDDFLKNNWDRTFSEDQMKPFVDHIKKGRLTVKKYILKEMWSEIESDLDKIIKNYIKIVKHINFELPKSNGNVPVMTHGDMWTNNFMFKVDTNGNCSNNLSAVIDWQTIFKGTTGHDISRILVVSAPTDVRREIEKDYLPNFYERLKDSLTKSGKEIEISYETFMNNYKLCFVEQSLMLILMIGFALQEYNVPEESDYIWDARKFNIGSRVYYNLCDAIKICKELHPEWLENSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM94</accession>
    <name>A0A0N5BM94_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM94"/>
    <dbReference type="STRING" id="174720.A0A0N5BM94"/>
    <dbReference type="WBParaSite" id="SPAL_0000703400.1">
        <property type="protein sequence ID" value="SPAL_0000703400.1"/>
        <property type="gene ID" value="SPAL_0000703400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000703400.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16096" checksum="0559696599AFA157" modified="2015-12-09" version="1">MSLFVRSSRLRRIFVGKNYCHTTINEKSIIDTKLNPRHKNIAEGKINPIQYDWEKEVSQLRERFGTYGLASGVDLSHLWPTVEEINEIQACKMYSPFKDVLEMAKLEGEKRERELEERMKTLEENEKKYSEKANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNC7</accession>
    <name>A0A0N5BNC7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNC7"/>
    <dbReference type="STRING" id="174720.A0A0N5BNC7"/>
    <dbReference type="WBParaSite" id="SPAL_0000740600.1">
        <property type="protein sequence ID" value="SPAL_0000740600.1"/>
        <property type="gene ID" value="SPAL_0000740600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000740600.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50805" checksum="39104F3C28113F8B" modified="2015-12-09" version="1">METKRGPDNPKQIQEIVSNFDIGELLGSGSFGAVWKVRNKKTQDYFALKLSAETAYPVSMKCEVEVLKRCNGSCNLPKPYYFGKWNHQYYIIMNYVPHDEFMEVLYTFTNKEIVEYAKNLFIALEYLHSRGIIHRDVKPGNFLYNRCEKRYMLVDFGLSSFYKPLEENILTPVQVNLDNRRDSLTIKRKISSTEGELEENCENIKRRNGDSIAIVDERDKKYSTKIKNICNCYGKPVYCSKCKNLPKFSYCRSGTNGYRAPETMLFCKDQTTKIDIWSAGCTLLSIACQLPSFFRPSDEFQALFQYACIVGTNSLKEAADYWNVDLIMSLRSTRKSFFLISKAMKKKSIYSIKDFTDSGCYECKNYLTDNPDGICVCFKNNCIYPYEDKYEEMVIKILNWCLIPHPKKRFSATDLLGCIKDFEESIYNEGCGEKIELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNE6</accession>
    <name>A0A0N5BNE6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNE6"/>
    <dbReference type="WBParaSite" id="SPAL_0000742500.1">
        <property type="protein sequence ID" value="SPAL_0000742500.1"/>
        <property type="gene ID" value="SPAL_0000742500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000742500.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34093" checksum="FF722C05C27B00B8" modified="2015-12-09" version="1">MSGNDSRIKEAKACIAKAEEHLKTSVFKMKFKPDFDMAAMEYERAAVCYKNANDLKNARDCYLNASKNHHLNRNFFHEAKAKENAASICKDLKESISAAKYIQEACESYVLSGSMDTASLTIDKCAKWFEYSEPETAITMYEKGLALVQQTDRSKMAGEFMNRLTNLYIRSEKYDKAIKIINDEIDKYVETKDYLKVGQLSLSLTILGLAKGDTIETSKLLNRCFQADGFELSQEAAICGNLIKAYEDGDDDNFQNLLKNGLIRSMDNDYLRLIKKIRVPDINGVESSGITFENEDEDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPG2</accession>
    <name>A0A0N5BPG2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 33 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPG2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPG2"/>
    <dbReference type="WBParaSite" id="SPAL_0000778700.1">
        <property type="protein sequence ID" value="SPAL_0000778700.1"/>
        <property type="gene ID" value="SPAL_0000778700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000778700.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29630" checksum="8BB71527502031B1" modified="2015-12-09" version="1">MVEIREETPSEQNNTNSDNASTSNRSSVPPRQSVMEYLKADPSNAFLCILRIATVFFSILYLLPSRDNGTYYNKAMIAAAVTNGIRLSQRLGGNFQLTREFITNAVLEDSFHYLVYSLIFAVSTPMTMALVPVSLFGLLHSINYINKVAQNTGHGNNGIIVKAHTLVNQQTDNLLGIVATGEIFMFPILFGLIFTGKGTIFLPIVYYKFLCFRYSSRRNPYTRIAFGQMKTSLTQASLSPKCPTIASSFIHKAIAFVERLAPQTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQS0</accession>
    <name>A0A0N5BQS0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQS0"/>
    <dbReference type="STRING" id="174720.A0A0N5BQS0"/>
    <dbReference type="WBParaSite" id="SPAL_0000823200.1">
        <property type="protein sequence ID" value="SPAL_0000823200.1"/>
        <property type="gene ID" value="SPAL_0000823200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="328"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000823200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53945" checksum="2B1D29F00E66AC7D" modified="2015-12-09" version="1">MFIQKIKNKWNLLKKKNNLHDSREEEAKSVRPDFKNNTTFMEVSGNPRTQILSISNTQSGPTSVVSSGQSNNSKKVGRRRYNKPLRLPKKEALVYKGGCVINKPKRLESGLDGTVKKNPKEMTEPFTEFAISKEIKGLKEMYDAEFNNDLNITPDQAKAFYDVKNKDKNRNKNVPCLESTRVHLMISDQFGNDYIHANYIPTSKAGDRMIITQAPMNYETNISSGSQPVIMSTASDFFRMIEQEECEFVVMLCSFSDEKETTCCQYIPLIGSTNIGQYKVTTLSREPLPEDNNVILSRIQYLRKDEKKPKEFSHLHYLDWPKEGFPKPWVLTPINIYLRIKDSQKPVIIHCTSGIRRSGTLASIFMALDELDNGTLPKSLVPIVKHIRSYRLMAVRTPVEFLYIHLQLIHYFLHKGYIDNSQRLLSFFDDYDPAYKKQAAKEKTTQCVSEYGIKTVKTPLTPQNQQPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR77</accession>
    <name>A0A0N5BR77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR77"/>
    <dbReference type="WBParaSite" id="SPAL_0000838100.1">
        <property type="protein sequence ID" value="SPAL_0000838100.1"/>
        <property type="gene ID" value="SPAL_0000838100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000838100.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25281" checksum="A0AA62865B6EA058" modified="2015-12-09" version="1">MTFAIVSVGLVFRYHILCKRILLPRSKLIRSYLICFGYSIFSGVLYSLNFSPYVPMSFRMEADLNETIWKYEEPSFWDHVLIYRQNNIILLLSFILYTTLTISSYALIIYLVYKMKKLMKNNKNSFSAKTLILQKQLNKILNVQSLTPIFVILLPVLFGLILIISKIRVNGFGLFVILGLESVPFVNGLSIIILTKDYRIKIKGKKNTPAKTTTKVFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRW3</accession>
    <name>A0A0N5BRW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRW3"/>
    <dbReference type="WBParaSite" id="SPAL_0000860800.1">
        <property type="protein sequence ID" value="SPAL_0000860800.1"/>
        <property type="gene ID" value="SPAL_0000860800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000860800.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8509" checksum="7AE9122C2F176612" modified="2015-12-09" version="1">MHSYFLIPYQLRSFSKDMDGDIEKNIYRQLLEYYNQEPPNFSDNFKRSFSFLPSRGKKLQERFNFQGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSI5</accession>
    <name>A0A0N5BSI5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSI5"/>
    <dbReference type="STRING" id="174720.A0A0N5BSI5"/>
    <dbReference type="WBParaSite" id="SPAL_0000882700.1">
        <property type="protein sequence ID" value="SPAL_0000882700.1"/>
        <property type="gene ID" value="SPAL_0000882700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="93"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000882700.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47908" checksum="EB8E064550EF26AD" modified="2015-12-09" version="1">MAPTLPKGNEMIKKIIPDFVEIDKLNEQLLLQWVHENHGHIGYNKMLHLTRNYVEEGEIQNLSGKIVKILKSCLPCQMKHKAYSREVTETPVVATAPGQLLAMDILGPMNETERKNKYVLLTMDVFSRIVTLIELENYKLDEVSTKLWQRVFLQYGYYHTVRCDNSGNFKNQQLEDWLANMNIQLDHSSEYHHSGNSLAKKYIGAAQQVIFKLCHNNPTQWDMCLKLAEFTLNTSTCSKTGYSAFFLMFAREPVLPLTLLTTCSKTGYSAFFLMFAREPVLPLTLLTNKSPYAMIENTPTMAQLTAQLKEIFEDMHELRIDEELNGKTTKAGYIELKVGDAILIMVHRKPGISTKLQPTYDSKIYHVVSISIDYVRIKGEGDRKSMVLHRTLIKKISHSTPNKGGSSENGENPTDIGKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTN6</accession>
    <name>A0A0N5BTN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP synthase subunit a</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTN6"/>
    <dbReference type="STRING" id="174720.A0A0N5BTN6"/>
    <dbReference type="WBParaSite" id="SPAL_0000921450.1">
        <property type="protein sequence ID" value="SPAL_0000921450.1"/>
        <property type="gene ID" value="SPAL_0000921450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000921450.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7768" checksum="D6649F97F1C47B7C" modified="2015-12-09" version="1">LLTFNLGGFLPYSFPFFRMAEFTLVFRIMLVSEFRRPLALTVRLTANVLVGHMLMSAVYYIVTFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVL9</accession>
    <name>A0A0N5BVL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVL9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVL9"/>
    <dbReference type="WBParaSite" id="SPAL_0000987500.1">
        <property type="protein sequence ID" value="SPAL_0000987500.1"/>
        <property type="gene ID" value="SPAL_0000987500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895:SF42">
        <property type="entry name" value="ACTIVATED IN BLOCKED UNFOLDED PROTEIN RESPONSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895">
        <property type="entry name" value="PROTEIN CBG03177-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895214" evidence="1">
        <location>
            <begin position="31"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000987500.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="75504" checksum="5FD483171E807C89" modified="2015-12-09" version="1">MSISLIDMKFNYNTPLIIVLVLINLSLLEASTIRSKRQCPCQVQSTPKCVCTPVQLSAYSVTPIKMSCSCTQQTTQSCSCGSSSYTTSRPITIISQTPLTSASSCMPVCQSSCLNKCSQKASYNQCQNICSNSCNTSCTQYSPSKTTTCSSGDCGKQTILVNFDEVENQCNNQCVTNCPPQNSNCQSSCKETCSCQAQCQEVCIQANQPKNQCDTGCVSACSSSSTSTPIVVNIELSEASKTQCLDTCGSACNTNCVTKTQNTESCRNACNTSCQTSCMNYNEIQQPTTTTQAPKVCLDVCMPTCTPSCVASQEVVQQLSATVQAISYYDQCNNNCNTQCAKTQLPQDQCNSSCKEVCTCQDQCNTGCLPTSNEQTCTATCEAVCQPQVIVQPIPVATTTSCQNSCEASCPSTTSQQQCSSSCQSTCCKSECQNSCVAQQTKSASDCSKLCDSVCGPITAANVVIQTQLLTTTQPPQTQVSDNCNNQCIASCEASSTQPSQCAGTCSQVCTCQDQCNNACVSQNHDPRQCNVSCMTLCTPSSIQSGVSSNQIQYQQPATNNDNNCLSQCQSTCTTTTNPSECNKNCEPICICQDQCTSTCVSQQQPIKQCQSACNNVCSAAATTTQSYEISIKATNNNCQEQCTSQCLAIDPTNTKCDSGCQIACTDNTTSQNTASPSIINCLKSSKNSGCSCPTGYDICTNQTQCCLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA2</accession>
    <name>A0A0N5BWA2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWA2"/>
    <dbReference type="WBParaSite" id="SPAL_0001010300.1">
        <property type="protein sequence ID" value="SPAL_0001010300.1"/>
        <property type="gene ID" value="SPAL_0001010300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11419">
        <property type="entry name" value="bHLHzip_TFAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010300.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46504" checksum="748D6A6581D3D65F" modified="2015-12-09" version="1">MQVLNIHEPLPSNEKCYNEEKESSKISDCINQINDFEDDENSSQGNSRSHSVRSGSGGNGSSTPNTPSGNGSNESNEVTLNDRRMRREIANCNERRRMQSINDGFQALRALLPRKYGEKMSKASILQQTAELIHNLQAEKDRLAQENETLIQTNANICKKKEQDEISHEAQLYKELELIKKSHHQKVVEYEQRLQEILTMYRDEQKLRQFFEQEYLANRKLQDSQLARIQLLQEKIPGILENNHIQNGQQLISQLAVTSCANSTPMDINPSIQNHIPQHNNLINYPPQNGNFRNAIFNNIDIHQLNQINLQTNNNNPIHNSSSNSLSQLGLKLSLSDVNMISQNQLTAIPGTQSLSLQNGTSVTSSRETSHAGSHQNLYAILEAIRQIEKNKVSVSSSSSTQNSSKSDVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWQ9</accession>
    <name>A0A0N5BWQ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPX2_importin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001024900.1">
        <property type="protein sequence ID" value="SPAL_0001024900.1"/>
        <property type="gene ID" value="SPAL_0001024900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001024900.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36625" checksum="45CDCFADABAC3681" modified="2015-12-09" version="1">MEKNCDDDYYIIPSVCTYRDFLTDSLDDSIGDKFFEKMRQEMKENELKMQKRESLPKRRPSVSKVNEKENISEGLPKREIPSIKIVPKQPVPSSTRLLSTFGKTPSKSETSVTKTKVELPSRRSARLGQPFTEDNRTENKQQLQPVLPSMQTRGRSLGPSINRTNSTGNSDPRASNRRLSNLLQNAVPTKPGNVVVPPKMPALTARAKRAASEPPKPDRSSRTVYNLRQNVQKPEKYEPPIIHRPPSSIRRSVSREPIRLTQRRANSVGPADRRPLLPSQIAPATPLSVNPTPKKVGVVTKERIMAMVERLSQPKKKTTVSTTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX31</accession>
    <name>A0A0N5BX31_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX31"/>
    <dbReference type="STRING" id="174720.A0A0N5BX31"/>
    <dbReference type="WBParaSite" id="SPAL_0001036800.1">
        <property type="protein sequence ID" value="SPAL_0001036800.1"/>
        <property type="gene ID" value="SPAL_0001036800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="3">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="4">
        <location>
            <begin position="359"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001036800.1"/>
        </source>
    </evidence>
    <sequence length="795" mass="92083" checksum="EFA40D746B49D069" modified="2015-12-09" version="1">MFRRHHGDANLRVPQNIYTVDYLRYLGDVLSNHENICKTNKKMIIDALNKLTQVLIWGDQHNSAIIDLFLERQMLQQIVNILRENYGTKVDVQILQTSNMLFTNFKNETSLYYLLSNNYVNEIITHKFDLHDEDIVSNYISFLKTLSFKLNSHTVHFFFNSLEDEFVLYTEACKLCFHEDNMVQTYARNITLFIYSIRDELMLNFIVRHSQEYFNILIDTMAEKAIDMDIFIRSAENVKGNRSTLENMMFVYNEYCSYISDIFKRENEEISNMLIRTMFNRLISPLFLVSLGGLRESPTTILLCKVSSFYFLTQLIRLISDVNFTHTLLSALFFGDQNEIGTQWTKNMEGVRSLSSRKKASTSQERVFFFAHLKSLEITNDDHSVFYGLFLLFAIYQKKCVQSDILEAARLPCENNSECDGQLFECLTKIISNCVFYSSPLRSVTLELALLILRHFVMFMESDHYMSTSIITVANDSSEKIINELQDLVFTEDSFLDFFESEYYIFERQQLKINEISEDASLLLNPPTTIGSLIPLAKRLPSTAEEKLRRSLYNWFQLRKFLHDLKSETETELPIIKYIQPVVEVGDKIQTDHVEIVNCTLITADKVVKNLFLVTDRFQLIFVEPQSKLGIVRYAGFLKDVKAFGISNDSKSLQIIIEDNRKNLVSRPTKCTVNSSNKEGVVLPSNLLFNGKVRFDDHIRCMTTKQRLDKGRTAARKFLIGHIAEIFKIQRPSKSVQNSPYISHVSKSRNPVNMYKFPGGVVVKDINNQREPINGTTVKKTSKLPQMNIPGVEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZB1</accession>
    <name>A0A0N5BZB1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZB1"/>
    <dbReference type="WBParaSite" id="SPAL_0001110400.1">
        <property type="protein sequence ID" value="SPAL_0001110400.1"/>
        <property type="gene ID" value="SPAL_0001110400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001110400.1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5871" checksum="CF5E22F31CAA4057" modified="2015-12-09" version="1">MEKRQNEMSQTINEMKSNSKVDMSSNEIKKPNFNKPGDGYLTGISQSKFGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C040</accession>
    <name>A0A0N5C040_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">cardiolipin synthase (CMP-forming)</fullName>
            <ecNumber evidence="13">2.7.8.41</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="2.7.8.41"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.41" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C040"/>
    <dbReference type="STRING" id="174720.A0A0N5C040"/>
    <dbReference type="WBParaSite" id="SPAL_0001137300.1">
        <property type="protein sequence ID" value="SPAL_0001137300.1"/>
        <property type="gene ID" value="SPAL_0001137300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000005">
        <property type="entry name" value="Cardiolipin synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001137300.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29115" checksum="E29679347CB36329" modified="2015-12-09" version="1">MIIKASYLSSYLKKSTSLLSLKRLLKPTECGRTVTFAKFITTDCGKNKENINNNIRSAEKKFKDRIYTIPNALCLARISLTPVIGYLVITEAYVPACTLFVFAGITDFLDGFIARRWPSQRSLFGSIIDPVADKFLVSVLFVTLTYSGLIPWQLTGLVLARDISLITGGFIKRYQILQKPITLQRFFDPSVDPVEMKPTLMSKINTALQLSLVAFSLTAPIFDFTNHPALTALCWVTAYTTLHSGLQYIGGKAMKKVNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C081</accession>
    <name>A0A0N5C081_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein SSXT</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C081"/>
    <dbReference type="WBParaSite" id="SPAL_0001141300.1">
        <property type="protein sequence ID" value="SPAL_0001141300.1"/>
        <property type="gene ID" value="SPAL_0001141300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18668">
        <property type="entry name" value="CD1_tandem_CHD5-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1059"/>
            <end position="1096"/>
        </location>
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        <location>
            <begin position="1153"/>
            <end position="1327"/>
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            <begin position="1393"/>
            <end position="1544"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="308"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="509"/>
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            <begin position="618"/>
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            <begin position="899"/>
            <end position="992"/>
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            <begin position="1678"/>
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            <begin position="1704"/>
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        <location>
            <begin position="2193"/>
            <end position="2247"/>
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        <location>
            <begin position="2330"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2444"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2604"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2698"/>
            <end position="2823"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
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            <begin position="102"/>
            <end position="112"/>
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            <begin position="145"/>
            <end position="154"/>
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            <begin position="155"/>
            <end position="184"/>
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            <begin position="191"/>
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            <end position="411"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0R1</accession>
    <name>A0A0N5C0R1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
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    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0R1"/>
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        <property type="protein sequence ID" value="SPAL_0001158900.1"/>
        <property type="gene ID" value="SPAL_0001158900"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000046392"/>
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            <dbReference type="WBParaSite" id="SPAL_0001158900.1"/>
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    <sequence length="112" mass="9839" checksum="0D5A5B6D009C2303" modified="2015-12-09" version="1">MDTILKHFFKDSCKALASTACSGAASQTVASTGAAIGSSTEFSSAQGTSAAGSGVTSTGASAGTSAGVSAGTSAGVSAGTSAGVSAGASAGASVGVSVLASAAGASAGVALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0W2</accession>
    <name>A0A0N5C0W2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab_eff_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C0W2"/>
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        <property type="gene ID" value="SPAL_0001164100"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="3667"/>
            <end position="3758"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="3868"/>
            <end position="3992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1630"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2155"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2415"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2572"/>
            <end position="2627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3798"/>
            <end position="3820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1630"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2417"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2572"/>
            <end position="2584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001164100.1"/>
        </source>
    </evidence>
    <sequence length="4049" mass="463954" checksum="BC9CF10F5920AFB6" modified="2015-12-09" version="1">XEESEVINQVPQSFMAQKQDIPTEEDKSEHSSYESSETSGADDMEIEGKQVEYQLTEEELAHIEYVKKMAEESEVINQRKISLSILLTHHLKLPVPMDKSEHSSYESSETSGADAIKSSFDSSFDQSHGIELPPYVKENSPIEEKSIQEIEGKQVEYQLTEEELAHIEYVRKMAEESEFINQVPPSFIAQKEDIPTEDDKSEHSLQSSETPGADDIRSSFDSPFDYSPSFEISTYAKIGLPVIEMTSEEKKYNSHSKLDEYQLTKEELEHIKYINNMSAEFDHNSQISNQFMVQKQKTFSEEDASKLSSTNSSDTSGPDISKSSFDTSFDQSQIMETPISMNVVSHTSSIDTTDNQKSSLTKFKDSCNIDTSKYIRNTNGLSYEERCNFKLSSQRSTPSRLRSQDNPFDNDYSNTIYEEPDDLYGDYRNSQDNNNRNLQHTTKRGSFDSQTKSRYCNYGILHSYNKQPRLKKINRRSMEAKVSLNREFSRNNTFNGEDSNSFNIQKRSSSIDLACHRRSTANRGKRSTFNDNSRLLNNINGFERCERRSYNTGTIDLTNINFLVRLNFYALKLSGEIAEKAGADLISYIKNQNNPRVRYFRNENTSYLQDDSVDSVETVEYIEEDEVLSDKEFKNVETAKASENGIKTSPFSINVIGLFNSTKSYLSLNRKNQAPSTPLLRLPSFSRSLSPESTHGINQQETPSRKNSDILNFIRRTSYSSTTFEPPIQLPDDALEGLTEDEINHISSVIKNANNSIVKSPRPSIQYDELNVEHLNKEEKEHVKNVIRKASEIEKQFNSKNYDNISQLINDVPPLTDEELEHIQKIKKLAEMDEAINASTMSTFNVNKRNNTSFSKDNSQVSPNSNDLPGEERRHSAVKVQMPNGLKSTSISYSNSLELTQEELEHIAKINQLAEQDAAMDTFYGRKSLDNIQSKEYDNELTEEELEHIRRVNEMAMRDIDYDSQFTNTVIDTLIEAQNDLYEKQESSLQTSEETDSADEVLADDELYDIERINKHLGDEYQLTEEEIKHIKRIQELSEQENTSSNDNIQFVQKEVPINKGKEDLSLTEEELEHIRMIQRMADEDEHKTLFKPTDKPSPIKNINNELTEEELKHIRNVQARILEEEQRSLLTSKQIVPEVHQLTDEEITHIRKIQEMAEIDEITSYQQPLHDKIKEFDICYFRNDKNNSKNILQSELINNYQKDDIPKTIYSTTPSKNIIMDNEEMSTDSEYNSYVNGNQMSSSNNYNISLPSDFIGPLKLQQYKSMDSSSTLESVSSSSHKKEYNFINERNDKSSSSKFTSTDTGNFSDYSDDSNQYNKKYSDMTKISKRLILLNDITKISKLKRSRSVDCLSLLESEEDTDLSSSLQTRYSLPLNLLPNNMKEYYENTQETKEIFAQIQQLNEPEYINKIFDVKEECQPRNIILNRGKKSIFGIEGKDHHMEWFIDKNNKIIHPKMSHDDKKYMDYSSTSILRKENEKRDIFEIDSSKGDSFKKDDIKISTNSLLTSVNEDKFNGGENSFIECKEIEKKVFESNLTNTKLSNDNIVGYSGSKKFGEVVSSEEKIIEKNTFSKQNISMFKSSNSGFSRFGSLGKLANAAISSAQKAGEQLTAVANNAVAQATSMDNITSLGQSTQQQKQSSQTTSLTTSSSKRSQSAFDISQGMEQKEGSMSTNYISSAIPTNIPNPIELPPGLEDLSDEERRKILAVLMEAENINNTGFNIYPQQQQQQIIDEKKDDINKMVQEKMDINNEYINNDRKSPLPEINNTYSVNLSNDNNKFIDNQMYFKSSPINVKETNNDISKSIPKIEDGEYLQSQLTNMSNKEKESLSQVDNINIFNENDKNINISSHANPLNERNNLNFKDEYNSFKDKNIVNENMYKDKGNIILSNDDTIKNNSISDNCYIDNISQYPSTTFQPHNLPQQTPPTYDSISSSYTYDNDIPSNVSPQYEFCEDSSIKQFENIEKDVYNSISPIKGNSVNLILSSNEKNSDICKVDGVELSGEIPYSSYDDSEDLDNIKLENVYTMKKPRMWTTVFTDENDSEDGLNENSSSGGMSNSINLIGKNDDWLMEDSSCQPMASDSKNRMTSLNMMGNSDEGYEIEMDDPLSQEMIITNSHNVTPSNYGQNHLDSNKMHIAKETPPVILVTSVKDDQHTHRYEDSSEGETSPSSDEDDYPDHVIEVPTITPSSMNYEDVTENEKKTALEKELIQQIQSFGEAANDEFDVRWKSENEINNTKANDTLKDQKLQDGIINKSQTINRINPFIDDSKFNDFTANDASTAYDDDISANDVVPTIIVKSSKGKISNKEENKNKSVPLPVPILRPGPVYTIPENTDEDSSANTEGKYIAHKIERKPLRVSLNELDKYQMKKNNNQVNKKAYIEDGGISPQKEDHVSNDNIIDNRRVYNNGISKQENINNKQSSIQSSKKSPTLSTTSSITEYAEQTNKRLKELEERLENKTIKDIETVKKQLDQLLQQGNMVKYDKGIINDITDGASIYDSRGLKYKGNDERCYDNDYSQEGHQNHDYPNLLPKLLNNVTEKDIIEASILNDNDNSFAKLKRSPAMILTSEDQISSRTSQNIEKPQGLKNDDETISQHIASSEIGRRKLPSLPIQHQGPSQQRYPIPSLYYSSSISNIPGTPSSTDNPKDFTLTFEDLAKFSLHPSGQTYQQHDNNKWKTLPGTFKLSNNLNDSVGKISQDNYAISTKVGLNNASKLLFTKEPIIHPGASFKKSTPTQQQMFMMPSTLQAKKLSQPDILYDNSIKLSGTLPLKLSSEKIPIQHSTLTQPIEKQHKMCDIMARVAFKKELKEKLAKRLLSNDKTEIEANQRNYKINKMYTTGIVTEIRPSELNLIPDTIKSDLPEEITRNARITKCKDLIDNIDTFGSLKSSFDEFDQKMKKLYNYSTSISSTLPSYHQSKSNNPAKSILSSTKLHQYSNTTPTTSNNIILSSKSVACQCDHPSPTPQVTTTTTGKTNYLEAETQTNILDTLTLPVYQKNINKTSDIKEDKDYTKENELYLINKTLNKNQSSNIYGTNNSNAECQTDVSWLLLQNKQNTKYHKHFRSIPNIPQYDDNFNNIYDCKTELLRCSRNEINYDNMRKYYNPNLPFTSTVQLNSLESNYYSPRGYINRLGNLNSQQMYSSLGTLNIGGGSGEEDLEFKRIDALNEIAKRKEKLNTLRRIKDTISGGSNYDLNRSLQHLSLNRYPEQLYKTDYSSTVPHYSSMPMLSDEVRSYGINSNTNSLLRDAIKNPYSTLGRCYRDEHLSKDNNIYKYNYHSSLPRNYGLHSSYDNQRTNILGYHESSSSTNQFHNNRDYINRPYLSKSVYDLNTPYQMREENDYGCLYDRQSYDIRRDMLNKNLSRSYSGLLDPYMTPYNNNIYRHHNHLNNTLHHKKEEMESEMLSEYANYLNKHYMSGGNNADNYLMDDSIPLNQGQIPETDLVYDNQNIVLPYYDNNMSNIKTNIPMDTFQNYYQSSTLPSQVYSRKETNYGARPFNRVGEYGNGFRNNNNLHDQQQHNQSFGIGRSNSYQSNDYQYNFNKSLPYNNEASLTDEINARLKEDPLSKIYATIGQNTYNRNLLNNYNNQQSINRSDYSSNYNQKLLFKQSPYLEASNSYNNYGNNYDTKNQYSSYNSTPRKTLSFFNISMPEDLPIKRRFRDIPIKRILLTRKYKNSHFFNDTGIRITGGKKLDDGNLGAFITAINKNHCYETLGQIQEGDRVLAINDINLSNKSYEEVERILNNTRGEFEIIIQQGCKKNDLSEDRMNFSGNEKMYDDVPGDINGIFRKPLKSTLKKSSTRSNNRQVYYEDSTPDGGFDGKIKEAPPIPAHRHEVHNPHYNINNSNYGRKNDYNFSPQRLTKSLNNSNGYLQVALAYDLPQNLLFVTIIAARNLKVKSTYDSIVLPNPFVKIYLLPNRKVSSKRRTKYIPNTSDPVWNQTVEYHVPYERLSTQWLEFTVWDYDKYSDSLSLGQVIIALSDSQIFDNQPRWYPLHSSREESSPLLSNNISSPSPYNQSFSKNLNKPSFIKGNTYHYNPNYLDINYPAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1E3</accession>
    <name>A0A0N5C1E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WS_DGAT_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1E3"/>
    <dbReference type="WBParaSite" id="SPAL_0001181800.1">
        <property type="protein sequence ID" value="SPAL_0001181800.1"/>
        <property type="gene ID" value="SPAL_0001181800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001181800.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19126" checksum="9E4DD99BE63FC424" modified="2015-12-09" version="1">MSSNGSTIAGGVAIKVIFKPILGLMDARDPRFMQKCYGRVQHRHMGDDFQVFVRHPNLEYYPIRTFSHDTNVSIGSVALLLEDILTIKIVIPLNLFYDCNPSTIIPDVVYERFIEYLISRLGDNKSQVSDPIIQYVKNEVEGRSIRQLPLETLSKMDKELTHGEYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1V3</accession>
    <name>A0A0N5C1V3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NTP_transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1V3"/>
    <dbReference type="STRING" id="174720.A0A0N5C1V3"/>
    <dbReference type="WBParaSite" id="SPAL_0001197300.1">
        <property type="protein sequence ID" value="SPAL_0001197300.1"/>
        <property type="gene ID" value="SPAL_0001197300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001197300.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45102" checksum="14D45A4EB33A391C" modified="2015-12-09" version="1">MSLKAVILVGGAQKGTRFRPLSFQVPKPLFPIAGIPLIEQHISQLCDLSSLSEIILLGFYKPEELDDFITQSEKNYNIPIKYYQEEESLGTCGGILAFKDKLLDKETTGIFVLNADICGDLPITEMVEFLNEQKDKKGLILTTEATRDQSVNYGCVVADEHGTVLHYVEKPTTFVSTRISCGMYLLKPSIFEAIENFKNTTGSEQIWFETDIFPEMASNNSLCALYTQRWWSQTKTAGAALYANRHYLRLYKERHPSRLANKEKNNCIIEGDVYIDPTAKIHPTAKIGPNVSIGADVVVGAGVRIKESIVLSNSTIEEHSCILHSIIGWGSQVGCWARVEGTSIAPNPNIPFAKLDNKVLFNNDGRLNPSLTILGSGVHVADESVVLNCVVLPFKELTSSFKNQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1W5</accession>
    <name>A0A0N5C1W5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rad51 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1W5"/>
    <dbReference type="STRING" id="174720.A0A0N5C1W5"/>
    <dbReference type="WBParaSite" id="SPAL_0001198433.1">
        <property type="protein sequence ID" value="SPAL_0001198433.1"/>
        <property type="gene ID" value="SPAL_0001198433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001198433.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9293" checksum="9AF4884DE0A76B4E" modified="2015-12-09" version="1">MISIIYSLYRTNFNGRYELPDRQGHLNEFLNHLSRYVEEFGVAVVYTNQVMENVYGNTLCGENSIRPAGGHIIMHASTTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C292</accession>
    <name>A0A0N5C292_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001210400.1">
        <property type="protein sequence ID" value="SPAL_0001210400.1"/>
        <property type="gene ID" value="SPAL_0001210400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210400.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12489" checksum="0731E4577F5FD3A9" modified="2015-12-09" version="1">XLYVSYQDSDSFDVFKNLQYLKCISKDFIKVPETVKLFSIKQYECRWNKNSKHENERNLKAYFKKFSKSLKAKNEEYVFFNNIMHWDHYKCIIQNYNWHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2F4</accession>
    <name>A0A0N5C2F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2F4"/>
    <dbReference type="WBParaSite" id="SPAL_0001216400.1">
        <property type="protein sequence ID" value="SPAL_0001216400.1"/>
        <property type="gene ID" value="SPAL_0001216400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001216400.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15812" checksum="D2DAFABA48A8D271" modified="2015-12-09" version="1">MKCLLCFESYTDPGTEHVPYSAPCEHIMGKSCLERLKEYGSRSEFNCPFCKKRIIFESCHLKCLSLNEYISFTPNGKNQTKSNTTKNRRKGDFTDEMSILLKNVLFESMDIKEDVDKYLNSEAVVGDFLLRDLETNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2J4</accession>
    <name>A0A0N5C2J4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2J4"/>
    <dbReference type="WBParaSite" id="SPAL_0001220200.1">
        <property type="protein sequence ID" value="SPAL_0001220200.1"/>
        <property type="gene ID" value="SPAL_0001220200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895243" evidence="3">
        <location>
            <begin position="25"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001220200.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="77332" checksum="D2C62FB1B9402E20" modified="2015-12-09" version="1">MTKLFSIHLICIIHTCILFGLIISDDSTTLFDVENFPIEYFRGSDDNIYYRKQIFGKRQTGKIEIPGLNETKSVIVYEVHLTREFLTADDYDNDLKISIKNIRGNFNFTTHLQPREDNYGDHLTCNLFKCHIGILYDCPMHIDLCSTPDKIINFLYIGFVKSDEYDNLILKLIPKSNTNKNIFSIVFCPAERWIPKGSNSEFIVSNEDYFFPYNTVREDYRIRLVYCNGTGVKTFVSCGYIKQKFMPNINVGYQCDEYNNEEANRVYNSAENTTMAYLSYKKLNCKNYSAYDSSPYVAHFLPPGNNYDNVNDFKIGRLFKSAFLYAGHRVQYFGPRDIIGKVSEFENYIGYAINLEGKCEVPNLNATLRLKINRTVQGFDSKIHPKFERRDTYTFFSRELKNSPIGCHIVLDGIKGYSLKHFYGLRYSTSLLMFDETTQKYIEVRDVGKLVSNKMYKCTLIVKGNNSEAEKPDYIKETEFIIDIIYEKTNKSTSFYNSTVTKISTISNRSTISNGSTSPNNSTVTKISTISNGSTISNGSTGSNNSIGSDSSSKSNNSASSNKSMVWIIFGISLVITILIIIVLVILKKLQEKRKKSNKDLSISSSASKKTARSLIALPKVPNAEIINKKTASNGSKNVEKIMSTDNLKTKKEVTNSKQSAESTDSNLTNNAKNAKIRIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2X3</accession>
    <name>A0A0N5C2X3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2X3"/>
    <dbReference type="STRING" id="174720.A0A0N5C2X3"/>
    <dbReference type="WBParaSite" id="SPAL_0001233000.1">
        <property type="protein sequence ID" value="SPAL_0001233000.1"/>
        <property type="gene ID" value="SPAL_0001233000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001233000.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14018" checksum="F8632B212906402C" modified="2015-12-09" version="1">MLRFEPFNAFSALNVAAVSGFSADSLKNGTQKRVYYCQRCLNHDRLEPRKNHKCECAYANCSCPKCILVEKRRVLNTQLHELEDVSESPINLEHVKKDVDDIYNDNVDDNGSSSEHSGGGRIKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3G3</accession>
    <name>A0A0N5C3G3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitotic spindle assembly checkpoint protein MAD1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3G3"/>
    <dbReference type="WBParaSite" id="SPAL_0001251100.1">
        <property type="protein sequence ID" value="SPAL_0001251100.1"/>
        <property type="gene ID" value="SPAL_0001251100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001251100.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="68328" checksum="FDF2EE32EC767904" modified="2015-12-09" version="1">MATIENFNGDELILQKKELISNEISRPNSRASVTGSISGLSNILSTRKRPFAYSSGSERILTSRFLEAKEEISRLKEDLANSKNELEKLQSYKKENSEKLRLLTLDVESLKYELEREKSKKLIDNEKLLLRNELRDCKVALKKTVPQIKKLEAQIDGAKEVLMLNNLWTSTVQTSILKKSCFVKDEFIPSNEAVNEVIRTNYEETNGFTNKDDLQEHSTMKEEPDTVVGNNKFVDSIAIYKTKFDIPECSLNSYEETICSQRKKIEKLDNDYAILKRAYNKEKQRGQDVEMLTVKCNKLESQLEIQRNQYESLSKQNAELQMGISRDVFREYSGKNSFKTESELLRKIVAVQVENKRLKGLLKDNNISDDSDGVIMLHLKNNLVTDAQKEMVKEQLASESGVLSCEEKQKLLDEIKKWKEIAEKRERERDAAAGIVNSIMEFRKIVKSLFGYDIKIKNNIAELVFAENPNDVFQVQFDLTSNNFNLLESETTNKVKFSIDKYLNGKNSLPCFLAGAFIELYHYMYDNQQNDEYEGSSTQVQEWNNEDVDEEEGEEEEEYSDNNFEDEEYSSTNGGQTSGDHEVEEILILSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4E2</accession>
    <name>A0A0N5C4E2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4E2"/>
    <dbReference type="WBParaSite" id="SPAL_0001282300.1">
        <property type="protein sequence ID" value="SPAL_0001282300.1"/>
        <property type="gene ID" value="SPAL_0001282300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001282300.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13238" checksum="2AA5A33DB4C75F02" modified="2015-12-09" version="1">MELKNIKEQTSRELNKVMMELKKASDERDIFRNKYLLCNKTEKINNISSKATVNEKDLLLINNLKRKLSKYEENQKDDNKQLKIINGTLLETQVSLHIKICVMRIYNIIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4F6</accession>
    <name>A0A0N5C4F6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4F6"/>
    <dbReference type="WBParaSite" id="SPAL_0001283700.1">
        <property type="protein sequence ID" value="SPAL_0001283700.1"/>
        <property type="gene ID" value="SPAL_0001283700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001283700.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11662" checksum="DF743E0718653D9F" modified="2015-12-09" version="1">MSQNFEILVTEIINIGEGDGKRGVKRRRISENASQSTSKPRVKEIEIREEENNESIMLEDRRTSEAENNQITFLDGQKLSAFKLKEYRSVCIRELDTTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C559</accession>
    <name>A0A0N5C559_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C559"/>
    <dbReference type="STRING" id="174720.A0A0N5C559"/>
    <dbReference type="WBParaSite" id="SPAL_0001308800.1">
        <property type="protein sequence ID" value="SPAL_0001308800.1"/>
        <property type="gene ID" value="SPAL_0001308800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001308800.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38103" checksum="35D72303BC943C90" modified="2015-12-09" version="1">MNLEEENDNMFLYTVVGLLIVSFSLYMIRRYVKGKQYTENTKATDKIIIITGANTGIGKQLSREFNIRKGKVYMFCRDEEKAFNAKVSLTKYGCDATRFITIKCDLTSIASIKKSVEEFKKYEDHVDILVNNAGVMFVPKFTLTEDKCELTWQSNYLGHFVLTELLLPLLENSSGGRIVNVSSYLHTHCHEINLEKINEKTYFGPLKSYNMSKLAQVLHAKELTRRIRQKNALSKVTINSCEPGVVNTDLMRHTLLKYDIMKKITLPFRWFFFKTPQDGAQCPLYLSLSTTVDGISGKHFSNLTETTNVNKLAYDKDLCKELYDYTLQYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Y6</accession>
    <name>A0A0N5C5Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001336100.2">
        <property type="protein sequence ID" value="SPAL_0001336100.2"/>
        <property type="gene ID" value="SPAL_0001336100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001336100.2"/>
        </source>
    </evidence>
    <sequence length="246" mass="28378" checksum="E6641F48848717AB" modified="2015-12-09" version="1">MKNISSQQLSKTGPQDLYPKHIPLTLSSNQSDMEDSVVVKVIIRPSIMCLLKSRIVKYVTIPSSTLVKDLYKTILEDLDLGDLDSNYSKVIEEYSEWGIGAYFPNVDAVVGSVKLPTKDEIEVELSIPIKNYKYMKKKGMEEVEIVSFIHDRSTNGNSTMSTTLSNTLRRRSTPRANKIRYRGVELVYLEKWYKELDKKSPSRSLLKEYAATLNKISKRSEEKKVTALKLSRWFKRKQKRVDEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Z6</accession>
    <name>A0A0N5C5Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0001337200.1">
        <property type="protein sequence ID" value="SPAL_0001337200.1"/>
        <property type="gene ID" value="SPAL_0001337200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001337200.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29882" checksum="9C2D5C1C5939E6FC" modified="2015-12-09" version="1">MPKFVNKKGEENKKVYESEKDKVYESEKDNVEESEKNKVYECEEDKVEESKKDKVEESEKENDNINAKTPKIENKYKQILDKLEKLTKDGEGIKDIWKNEDEKKILMENIKDIYDVSSSNVKPSYNDLMNGISEFCKKLQTSKPIGNLILNFNNGTLENTKVYFTSSFKTKETYFIFVFGNIEIIKSTNVQKVFEYFMIFNILSQKVFLKVKTKIIYQLILRLSKIDAKNAVKNGNKLHKDVERLLTNEFGKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C653</accession>
    <name>A0A0N5C653_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C653"/>
    <dbReference type="STRING" id="174720.A0A0N5C653"/>
    <dbReference type="WBParaSite" id="SPAL_0001342800.1">
        <property type="protein sequence ID" value="SPAL_0001342800.1"/>
        <property type="gene ID" value="SPAL_0001342800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001342800.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43203" checksum="F84619E29C9FE3E9" modified="2015-12-09" version="1">MPSIDVGYACCRNVINYKNNQYEHKNPVIFSSEYLIIDSNYSLTNKENDTLLNSSIIAYLVLSPENDNKSESTVINMYNSESKLYSGQRLSYTTIYQFAEYENLVKYNDSGFAVIITPLYVVPDINATLRLKVNGRVQNLESKIDKKFGRLDIYSVDIRELDNVHVGCHAVPNQMKHPAFEDFYEKRYQTRLLMFDEKANEYNHQINDIKSLVSNTKYKCSLNIETSGYESLKPKYIVETEFSINLIDSSFIIWIIFGVSAFVTLLLIVGFIIFKKRQLRKKQFNKGLSMDGSTSTTESASKCASQSPSKCTSQSPSKCTSQSTSQSRNNSSTITSFVKNVPIIQNKIVNRGPMNINKKIVTKTSNINRMIEDSVFQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6C5</accession>
    <name>A0A0N5C6C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6C5"/>
    <dbReference type="STRING" id="174720.A0A0N5C6C5"/>
    <dbReference type="WBParaSite" id="SPAL_0001349500.1">
        <property type="protein sequence ID" value="SPAL_0001349500.1"/>
        <property type="gene ID" value="SPAL_0001349500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="445"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001349500.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69983" checksum="3EA0E55BCB6A19A7" modified="2015-12-09" version="1">MGSQGRNNQMSGGRGRGNSRGGFRGGRDSSFGGRGGFNKSPRGFSNDRGGMRSRDGDRGGFRSRGNDRGGFRGRDNSRGGFRGRDNSRGGFRGRDNGGNFRGRDNNRGGFRGRDNDRGGFKGRDNNRGGFRGRDNNNGNRGGKFGSDNRKRKFQNKEDDFKVVDNEYDPTVNQSDSEDEIETPAKFAKVQNQNSKPVKVPKKVEPKKDEKKKKEVVISFEDNEDETMESDEEHLNDLDEELDEEDEEILEDEEMVDEELLVDEEVSDEELLVDEEISDEELEDEEEENEIPQVTAKNAKTETKAQPQNGKTKVVKDDSSDEEPAPVKKLPVPESKSSSNLEELLKEDEERRKEREHCTIRIKTLPLDTTVEDMKKLAPSAVSVRFTRSKKKCGCYLVFKSEALCKKALKELSTKEFKGSKLDPKWMGIRDVEAQNKLAKQPINPLELYVGGMANFTPRTALEKAFPDGKVCIQFDPRGEQKNFCFVKFTDEKAAYKAFKENSSLIIHNQLVDVFYGRTWSIPTKLQEVAEKDEAEVAEKKGEPNIPTKKSEAELPRLRKDSDTTSIESIASSGEGIVELEDEEGEDEEMLDEEMMLDEEVYIESSDEEPEEEPEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Z6</accession>
    <name>A0A0N5C6Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6Z6"/>
    <dbReference type="STRING" id="174720.A0A0N5C6Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0001371100.1">
        <property type="protein sequence ID" value="SPAL_0001371100.1"/>
        <property type="gene ID" value="SPAL_0001371100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="307"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="656"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001371100.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="96660" checksum="CDC998236295645B" modified="2015-12-09" version="1">MDAGDGNLNETVKRILKEKPPNTAYIFENKGHFYLYGDDAILVSEEIFENDNLMDYIKTAESEEAVARYPFIASEYESVVWNLLVRLQHSVKHFTIKEGSEWSLLYEGTPSAPNDFELIAGGAGQLTPLCSTVFVKFINSVHSNGSIEVAYCNTKNYTISTFELQFGVNFQHLGHIITILDVKEVLAIKENLEAGENILEKFESFLHRVQVPIRFVREEEIQKIKEAKDVITRMASNSQEINQLSDSSIINLYVLLENMKIIKDFSNQTGLLCYQKYSFNDFVVLDPAAVEALELFSTIPKSYYADNSEGTVFKLLNYCRTSSGSRLLEEWLRRPLVRVNMINERQDIVEALRNEPSVKNFLHESFLPRVPDCISISRRLIIKKGTLRDCVEIFQLAEDLYKLSTHFEQLVSMSPNCEKSIHSVLLKPLEDVKQSLHNFVDFITKVIDVNTLTSGNYKVVPDFDKSLSEINDLLKKLESEANKEFESVRRGIDDPSLNIECGENGFTMTINLSGTDLVNKPKYKYTVLRNTEERGVVFVTDLLKEINKEYVKYLKDYKERELSYVEEVLKMAYENTPTINSMLDFVAQLDVFVSFAVFATSTTRKFVRPQILDHTNIEEERVLTITKLRHPVVEASPNVDFIPNDIKLSSNEGVGPRFVLITGANMGGKSTFSRSVALCVLLGQIGCPVPCDEARYTAVDGIFTRIGDRDYPEVGIPTFMNEMLDCANIIYGATPNSLVVVDTIGHGVSTFEGTGLAYAIAEEIIERKCFTLYTTYYTELKELKDKFPHIVQCLRSDYGYTEDGELISSFKMIPGVAEKSSGIELARRLGLPEDFLQMASKYYEEFSKLGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C730</accession>
    <name>A0A0N5C730_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C730"/>
    <dbReference type="STRING" id="174720.A0A0N5C730"/>
    <dbReference type="WBParaSite" id="SPAL_0001374500.1">
        <property type="protein sequence ID" value="SPAL_0001374500.1"/>
        <property type="gene ID" value="SPAL_0001374500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001374500.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65083" checksum="6909099BBEE7F941" modified="2015-12-09" version="1">MAGVNVNDKIFTCRKLPLICSEQLKSYLMVNGHSLDEFQINEPQGPPITKKFNDHLLNTYKSPPALEPHPPSIAPTDQIDNSINSLSINNQEFIVDIPPSTTPYIDQAKKYEEDVTSQVDEPFIAQNNVYDNQFVKPTPSPYYRPEVVSTILNYPTTPTLTPPPSPIQISNVAIDNYGIPNPPSMPSINVAPQMPSINVEPQMPSMNLEPQIPSINVEPLMPSFNVQPELPSFSNQPQMPSYNTQTEVPSFNVQPEMPSINAQPQISTINVEPHIPLLNIQQQIPSIKVDPSPLYIPSTINYNQKPEPTPFHIPTPVFTYNLHNQDNQPPSFGPIQQPPSSLYIPSTINYNQKPEPTPFHIPTPVFTYNLHNQDNQPPSFGPIQQPSPYSKINNYKAKKRPQHVPTSLSKYGYYNDGYSYKKNTWKQANKKLKKKVLYSDSGFFNGLRDLSKKCCTWALNGMCDGYWQRIRLICPKSCGTVVCSTGDGKTGCNRAIDVNVYDCERQNEYYLGVQRDPLNGGLSRPLYNHLNNYESTSIGYQKNAYDNDNINLYSGNAYSIENEMIGWKKMFRSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7R2</accession>
    <name>A0A0N5C7R2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">phytanoyl-CoA dioxygenase</fullName>
            <ecNumber evidence="10">1.14.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phytanic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phytanoyl-CoA alpha-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.18" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7R2"/>
    <dbReference type="STRING" id="174720.A0A0N5C7R2"/>
    <dbReference type="WBParaSite" id="SPAL_0001397300.1">
        <property type="protein sequence ID" value="SPAL_0001397300.1"/>
        <property type="gene ID" value="SPAL_0001397300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000012">
        <property type="entry name" value="Phytanoyl-CoA dioxygenase, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0847">Vitamin C</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001397300.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35774" checksum="76686CCF49B421E1" modified="2015-12-09" version="1">MTTTKVSEDNFQIGNSVLTDRERKQYETEGYIVRKNCVPKYEIDRYYKRFEEICRGKVHIPTMTVMKDISILKEEFEGEKNITKIQDFNEDEVLFSYCCYPKVLDVVKDLIGNGSRNPTILSMHTMLINKPPDSGKLTSRHPMHQDLNYFPFRPPSGICCAWTAMEKINRANGCLVVVPGSHKGQLLKHSYPEWEGGVNKAYHGIQDYDPSSPKVYVEMECGDTVFFHPLLIHGSGANRTNGFRKAISCHYANDSICRYVDVKGTIQEHVEEEIIEMAKKKFAKRGITDVEITFQDIWSIRAKACCGKRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7T6</accession>
    <name>A0A0N5C7T6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7T6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7T6"/>
    <dbReference type="WBParaSite" id="SPAL_0001399800.1">
        <property type="protein sequence ID" value="SPAL_0001399800.1"/>
        <property type="gene ID" value="SPAL_0001399800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="272"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001399800.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62813" checksum="9C5BF80119DE9377" modified="2015-12-09" version="1">MEGNNENVNTEVSKGVCYCNGKRELGSLEIHCIGCKKWFHTKCFKDLKDFYGLPFMVSYTFHCKDCSPTKKETWTGKTVTFIHMCVMAMANITYNKRVETGKYDERYYFDVDTVIIPYFSRNWENLTGEKKRIKNTWHHTLKRTLLKENNLFVAQDANHYALVESDLEKIGPLMEGLKNPGRKPGSLSKENIENKDVDNVATTRQTRGSRKRATDDKKVVGKRAKLSGENGFDKTGSEDSTIDYPLNKEGNRYYLAVKDIAFPDHEMYTNTLVTNTSLRIPTFVYRLADVSRVTLSPSDHAPQLILTNDNLTVANIECEGYCMAKATHSVSKGKWYYEITFDSQPSGTHIRIGWATKDAVVQAPVGYTQFSYSWRSNHGTAFHKSRGKRYANRDFKEGDVLGCAIYFDEPENITNRLPPSAKSSYTVVNHKSNIFFLNFTESEALKKERPVIKGSKIEFFLNGQSCGVAFEDIYEDFYYPAVSIYENAKVTCNFGPNFIHQPPKDVKPMSERVFEQDIENCLSDMLYFVENNKEIEKTRQLFMEHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7V0</accession>
    <name>A0A0N5C7V0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7V0"/>
    <dbReference type="WBParaSite" id="SPAL_0001401200.1">
        <property type="protein sequence ID" value="SPAL_0001401200.1"/>
        <property type="gene ID" value="SPAL_0001401200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001401200.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33729" checksum="14334AF287E58193" modified="2015-12-09" version="1">MGNNNCRICHIGGRLWSLYKTSNDLIHFYRGSIDIPFLKPYNNMVLDGFHDIVVGILKKALSNILPSFQKCSSMTNVQMRNSILQYAEANNCFHYLNTLLHETVFDKYVSGGTLNKLTGSQINAMSFSLYNLMKDYINDNNVEVNRLKKVKNMIGILKSLLNLVVILSNGELDYKTAARYWEQSANNFIAGFDVETGFKLKWSIKVHNILHYNEMILHFKIPPYWMSTMRFENANFKLKQVLASTSSRINSPKTIVKKIKWMSFLQSYTNVKETYSNLRTWNYDIPLYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C872</accession>
    <name>A0A0N5C872_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C872"/>
    <dbReference type="WBParaSite" id="SPAL_0001412700.1">
        <property type="protein sequence ID" value="SPAL_0001412700.1"/>
        <property type="gene ID" value="SPAL_0001412700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056680">
        <property type="entry name" value="DUF7778"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36947">
        <property type="entry name" value="PROTEIN CBG04364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36947:SF6">
        <property type="entry name" value="TLDC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24998">
        <property type="entry name" value="DUF7778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7778" evidence="1">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001412700.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25755" checksum="4DBC7CE37F9B8A84" modified="2015-12-09" version="1">MVWNKRPDLEKQVKLDNQNYYFTNNLKKDVDLPDFHCNDLSFIHPVRRDFVLVICTIKGLFFNASSKCKERFVVFTKTGLLLIYKSNNQGILVNVKHAKSLKFDRFTISFEGERTKFHGITLSYDFGKLSLLLNHTQRSSFCQDLMALYHESPHHTNINDQITRKGNDNDATQQLINCYQNINCENNDQKCEILNKSSILTMKSFVDGCKMTSTPINNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8C4</accession>
    <name>A0A0N5C8C4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MANEC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8C4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8C4"/>
    <dbReference type="WBParaSite" id="SPAL_0001417500.1">
        <property type="protein sequence ID" value="SPAL_0001417500.1"/>
        <property type="gene ID" value="SPAL_0001417500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001417500.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24257" checksum="F7EE312BC49435E0" modified="2015-12-09" version="1">MVTLFKIFSGNDSFCGNLTIHTQKIFSPKISQLIEKKASDNLKDCLNYCCSLENCNSVTFSGILQSSTSLKEDDDQNCQLHACPLNNCLLIDASEQSTGVVSIVISRDISQITPENTLSVNNTTRKDFLTPITIEAAPETVNSTTPHSISGIFITPANSNETFAPVWIIGIAVIITIVCVGSNLIFFVIYFCYRRSRRLRHTAEITTIKTPTLHAFNPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8D4</accession>
    <name>A0A0N5C8D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 134-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8D4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001418500.1">
        <property type="protein sequence ID" value="SPAL_0001418500.1"/>
        <property type="gene ID" value="SPAL_0001418500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026321">
        <property type="entry name" value="CC134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15002">
        <property type="entry name" value="ERK-JNK_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895526" evidence="2">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001418500.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30536" checksum="032E0885DBD807CE" modified="2015-12-09" version="1">MLFCRRTFVLLQFFILYIRFAYLAVDPHHNHNNHEKVHQPINHKEITKEAHSKYESESPSKQYSELLRIKRREQLNSIQSLSKQKDYKKQKDTVKQLINAIRKVFMEDMQILSTIEMNNIDEVLSDKSTIRDKFSRVLENIAFFGDITLRFPLQSGIKYNKDIEFKNAVNWAYTFAKNFSHLYDDGTLKMFHLFAQELKIIPREADYHNPYDITNIKENLIREASLKMEEELEQKRKAKKEATLKIKKDKSHHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C998</accession>
    <name>A0A0N5C998_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C998"/>
    <dbReference type="WBParaSite" id="SPAL_0001448100.1">
        <property type="protein sequence ID" value="SPAL_0001448100.1"/>
        <property type="gene ID" value="SPAL_0001448100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF24">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001448100.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19680" checksum="2C6F664AD30BC0AC" modified="2015-12-09" version="1">MFENGQKDPLGSLWRGSGQYGSISSIRSGRRWGIRESIRGSMRLQPKLVGAVGNLLCNGFPAKSVKITLYYKNNMKVKTYLDEINSNDRGAFMVLRKNKSHSENPIVSITHTCNEPDKRCYFVVPFVIPDYYITTGYQLKFVFSVGTLELSKFYQGQRIECTKRLSRKFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9C4</accession>
    <name>A0A0N5C9C4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9C4"/>
    <dbReference type="STRING" id="174720.A0A0N5C9C4"/>
    <dbReference type="WBParaSite" id="SPAL_0001450700.1">
        <property type="protein sequence ID" value="SPAL_0001450700.1"/>
        <property type="gene ID" value="SPAL_0001450700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519">
        <property type="entry name" value="FIP (FUNGUS-INDUCED PROTEIN) RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519:SF6">
        <property type="entry name" value="LATE NODULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001450700.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37938" checksum="4CD523C7D012CB37" modified="2015-12-09" version="1">MIFLFKGFCIRFLNYNLLLNYFILLFIFFNISSTERCPIFFGAYECPRNHTCVNTECHNKDGKASKTCDDVVCGDEFKCYNGVCWPVEGIPCDRNTLVDKDIANAMSSDCGPKGKCIGGRCRLDKCWNVICHEDEMCRGGKCYKMVDNFCWNSFNCGPRFKCVNNKCKMIEDLPREKCNCDPGMICKNGQCMIQDNCANIACELEEVCIDGICSSLLGTKCAYDGDCGEVLVCKQGICVEDLECRNKCPFDNVCREGLCAGIQGLVCEEGSCGDGYECINGECLKNNCMNVVCQIGERCDNGLCIRVEGSLCSHAPKDCGPLFKCINGICRDFIKEMMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA43</accession>
    <name>A0A0N5CA43_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA43"/>
    <dbReference type="STRING" id="174720.A0A0N5CA43"/>
    <dbReference type="WBParaSite" id="SPAL_0001476900.1">
        <property type="protein sequence ID" value="SPAL_0001476900.1"/>
        <property type="gene ID" value="SPAL_0001476900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="51"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001476900.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24387" checksum="B7D85D369362BF6F" modified="2015-12-09" version="1">MENLDLYEDDIILTEKQVDEMVDKLVKQADEKKIDVSNIEDKSRKPKRGKRSISSSTNNMWTFPIPYYVETGVDATLVTTALNFIESETCVRFTKSATPITGKPGLRYYKGTGCWSYIGRIYTNASQEVSIGQGCGLNAIIQHETAHALGVYHEQSRPDRCLYVSIKTENIIAGKESNFAGSIPGYVNEYGIPYDFGSVMHYGRFAFQKMAIKLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA85</accession>
    <name>A0A0N5CA85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA85"/>
    <dbReference type="STRING" id="174720.A0A0N5CA85"/>
    <dbReference type="WBParaSite" id="SPAL_0001480900.1">
        <property type="protein sequence ID" value="SPAL_0001480900.1"/>
        <property type="gene ID" value="SPAL_0001480900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001480900.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16245" checksum="41C9352578C22F14" modified="2015-12-09" version="1">MSGRKGKVREEQPVISLGPQVREGEIVFGVAHIYASFNDTFVHVTDLSGKETVIKVTGGMKVKADRDESSPYAAMLAAQDVSERCKMVGINALHIKLRATGGTKTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDCTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAK4</accession>
    <name>A0A0N5CAK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitellogenin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAK4"/>
    <dbReference type="WBParaSite" id="SPAL_0001492500.1">
        <property type="protein sequence ID" value="SPAL_0001492500.1"/>
        <property type="gene ID" value="SPAL_0001492500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001492500.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34740" checksum="6C8E53A3B859930C" modified="2015-12-09" version="1">MSKSISGDKICLQNAKIAFMDYEIQLQAPDPHGVGYITGTTMCRDEIVHFDAKENYSRVESVYDYDINRPQCISYNPNVQEVVLESYLMKAYPKQVATPKYNRKYSNNKIYKINLVICQPKICSTEILTPNALVPIFITSYLVGSRYQKGDYNMLKKSDIYDAEWGYSFQLKTALKLKHFGVRGEVEFHDSRDAFKMCEKYEFPWRRVKYSLAFGFHQAVKTGLGKDLISTSNKVKEAHSHPKNKAVIKDISEMHEKYQVNWLNKSTLGFVNFSKTISIQKISKNVSNPLKIIKEPEYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBP9</accession>
    <name>A0A0N5CBP9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBP9"/>
    <dbReference type="STRING" id="174720.A0A0N5CBP9"/>
    <dbReference type="WBParaSite" id="SPAL_0001531300.1">
        <property type="protein sequence ID" value="SPAL_0001531300.1"/>
        <property type="gene ID" value="SPAL_0001531300"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001573300.1">
        <property type="protein sequence ID" value="SPAL_0001573300.1"/>
        <property type="gene ID" value="SPAL_0001573300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001531300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001573300.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13643" checksum="4D720273C6EAFF7C" modified="2015-12-09" version="1">MSGRGKGGKAKTSGKAKSRSSRAGLQFPVGRLHRMLRKGNYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRINPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIPSSLVPKKAAADDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBU6</accession>
    <name>A0A0N5CBU6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBU6"/>
    <dbReference type="STRING" id="174720.A0A0N5CBU6"/>
    <dbReference type="WBParaSite" id="SPAL_0001536000.1">
        <property type="protein sequence ID" value="SPAL_0001536000.1"/>
        <property type="gene ID" value="SPAL_0001536000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="114"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001536000.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="57136" checksum="E9E6AEC14912D99F" modified="2015-12-09" version="1">MSDEYLTSDNEYDDMSDSSESSTSYVEHEQQSTSSHYKLLENKHLVSEMDRILDEVRSVTNLPKTYCRILLHQYKWDKQTLIEKYYEQEPDIFFKKYNLINPASINRSIILSTTKGICNICCSDEVLTESICGHRYCNQCWLNYFKTKITDHCDHIISCQEYGCDIAVDDDMVIKIIGQSAPLICRYKKLITKSFVESNKNLKYCPNPECYFITKVVSFEDEPIICKCGFVYCFKCGHEWHEPLHCDIFKRWLRKCSDDSETSNWLNVHTKECPKCASTIEKNGGCNHMICHRCKYEYCWVCLQEWGPHGNNWYSCNKYNEKKDANNQTNVTQARAKLNRYLHYYQRYANHQQSLRLEGNLNSTVEEAMQLFQNEGMSWIEVQFLKTAVSILSNCRKTLMYSYAFAYYLERGNQTDIFEGNQADLESSTESLSASLERLSEDTSMMREIKRKIQDKCRYVDRRRVVLLNHIKEGYEQKSWTFTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCD6</accession>
    <name>A0A0N5CCD6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFL1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCD6"/>
    <dbReference type="STRING" id="174720.A0A0N5CCD6"/>
    <dbReference type="WBParaSite" id="SPAL_0001554600.2">
        <property type="protein sequence ID" value="SPAL_0001554600.2"/>
        <property type="gene ID" value="SPAL_0001554600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="9">
        <location>
            <begin position="515"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="10">
        <location>
            <begin position="638"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001554600.2"/>
        </source>
    </evidence>
    <sequence length="744" mass="83812" checksum="CBAB92B09ADC06F2" modified="2015-12-09" version="1">MATWADIQKLANELQIAQNFEGEKKLSDSNVIEIVSKLRELSLIDIIFSNDGKEYVTKKRLQSEIMNECVGRKGRVSMDDLVMSLNVDYEYIVEGVKEICSSDENFISFQSELYTKTFMDNLCNEISDKLDDVGTMSVLSITKLFDLPTAIINTYVLNEIGNKIAAVKDGDTIYTRRYLSAQKMYIASILSSVTKVTPMEKIVSVIPVSENIFWSLWNELEKENVINGKLFGLKNSTKKNFYIPKYYIDLTLCYIKSKFNSDGIIDSGIFKKFFITNINETFDAIYGKSFSKNIIHLDSIIIGKEKLTDYINEMENDARNSGWCDVVGYLRNELSYPITEVDIDIIKEKYWKLSNDLKFLDTPDASLILYKKSLVDTIKKFLEPIVKEIAVKEAPNLIISIKEEQTKGKHQQNSDDEDWGTGKGGKGSKKKGASSKKPAKKSTTEVRKGATIPLPNATLLKQLEKENLAPENIVKCIYKEISTDLEETFNNEIIYTMNNLSLTRSSDQKKNRKVLEQNGQTLYETFCILEQGASHFPDKTGTDLKDYLLKNTGIDFANIILSIISERPVEELTSPGTRNKIIKEMDCDNDMKEDILSLYASTTSGDVNLFHEAVKTLGNKNSCGLVFKRPHESLVPDLVSSYKDGLVKALQESTDHAKSLLLGILILYADRYKIAVSGSGKFVGNFILNFKNSNQVNEDEISLLTSAQGAVIEVFKSKGNVDGTLKEQLDEAIDEIKNIVINKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCH5</accession>
    <name>A0A0N5CCH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCH5"/>
    <dbReference type="WBParaSite" id="SPAL_0001558400.1">
        <property type="protein sequence ID" value="SPAL_0001558400.1"/>
        <property type="gene ID" value="SPAL_0001558400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895684" evidence="1">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001558400.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9811" checksum="7DC56738B40408D6" modified="2015-12-09" version="1">MFFKVYLTIIAIVLVTFLLNCSAQLDDSGSDVFYSAEEGTMPKATNIPKILESSDSEDDEWYSAEAFEKRSPTAEEIVIPQQPTTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE14</accession>
    <name>A0A0N5CE14_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE14"/>
    <dbReference type="STRING" id="174720.A0A0N5CE14"/>
    <dbReference type="WBParaSite" id="SPAL_0001610500.1">
        <property type="protein sequence ID" value="SPAL_0001610500.1"/>
        <property type="gene ID" value="SPAL_0001610500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="50"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001610500.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45627" checksum="26D5AE1C82D15D88" modified="2015-12-09" version="1">MDNFTQDDALNFEFYTKFIEPFEEKKNLEKYITYCVVILFSFIIVIGSMGNLLVILVACQKKMRNSTNTLIIGLAYSDLMFLVFCVPITAITYTSQIWLFPIWICKLVYYLQHTSAYSSVWTLTLMAVDRYLAVCHPVSSISIRNSKNALIALILTYSIILISQIHVARGHGIYHYNFIFENRSTCAMEKIAYGTASLTETRFYYFSFNIFGYLIPLLITCILYFYMLRRLWYPSRYVSGRLPRQKDGVIKVNYESTRVKKKATKLILIVVIIWSFCWLPFNVVSMLSGVVYPSTITQLWGKHAIICTVAAQVLAYANSCLNPILYALISESYKKGFIKIAIYILKMGRLSPTKWCISQLNDTSIVDVSKDRSIYLNANLRNRHHVLHLDSFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEB6</accession>
    <name>A0A0N5CEB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase C</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CEB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001620600.2">
        <property type="protein sequence ID" value="SPAL_0001620600.2"/>
        <property type="gene ID" value="SPAL_0001620600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="423"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="8">
        <location>
            <begin position="837"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001620600.2"/>
        </source>
    </evidence>
    <sequence length="1437" mass="164273" checksum="A51F91E55FE2E938" modified="2015-12-09" version="1">MVSSDLSSYDTDVKAEEANLQKKSSVRIRPVVIYYDLSASFLSPKCGERRRSSIFKAVDTNLVPQFGIDENQNEFKVSPETKINVSKRERDLLAFSRSFKKVKRIKSLGSNVHYNRANRNKKKLKKYCDHYLPNERLLRRCFSMPATLDSNLKNNTKSISQADEARNVSGDYFNHSNDLLRINSKRIRSNSCTPMSEEKKQLISVPNKKELLTPYQRFCISRTNKSFRYNKTTLLDANENESGGSAFYKSIDAMPNMNISTAKKSIPLVSELTMMTKRAQAGLANAARTTFCNDELKLLVYRKTLQALIYPISATTPHNFRPANFQTPTFCNECESLLWGLVRQGLRCSECNIKVHEKCRDLLSSDCLHRAAEKSSKHGEAGKAQNLMAIIRDRMKIQERNKPEIFKTIKCTFGMSDKIQQETLKEVKSSILEGSSKWSAKIHLTVVSAQGLIAKDKTGKSDPYVTATIGKVKKRTRTIHQDLNPVWNEKFTFECHNSADKIKIRVWDEDNDFKSKIRQKLTRESDDFLGQTIIDVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQINVEIKGEEKIAPYHVQYTCLHEHLFNYHYNTDNDDIKLPEASGDDAWKIYFEENSQEIVDEFAMRYGIENIYQAMTHFACLCTKYMCSGVPAVLSTLLANINAFYAHATSTSNVSASDRFNASNFGKERFIKLLDQLHNSLRIDLSMYRKYFPSSSQAKLKDLKSTVDLLTSITFFRMKVLELPSPPRASNVVRECATNCMKTTYQAMFDSCIENGAPSADSVKFWFDFLDYMMRVIEDDKNIYTPVLNQFAQELNIGNLSAATLWNQYKTDLKMALEEHSVSKKCTTPEYMNLYFKVKGFYFKYVAELPFFKDSIPEFPAWFIPFVMDWLNENDEHSMDILRNAYNRDKADNFPKTSEHTKFSNSVVDVFSQLNEALKLLKQMDCPNPEVSAEMMIRFSMTLNKVLLAYADMVQKDFSKFVNNESLACILMNNVQQLRVQLEKIYENMGGKELDKDASNVLTELQKKLNAVLEKLSLQFVVSLEPSIQKNMNLLAINLSKVKGPQVPKNQLNVEAEVVYAPLMDLLEGSLERYCIQCEKTVLKKILKEMWSVTITSMEKLVVLPPLGEKTVLNKLPNAKIGDVTKIMSSQLRDIKGIGSVKEMMDIAKDCERSLTPKQCTVLDAGLDYIKQSFHANGQGLKMTFFEKSPEHQSLKYALSLYTQTTDQLIKTFITSQKTQNLFSEEQPVAEVSVEVDLFSHPGTGEQKITVKILAVHDVRWQTTGTFKPFVEVHLVGPYLSDKKRKVATKSKTGVWTPRFNETFNFLLGNEGEPEHYELMFQLKDYCFAREDRIIGIGVLQLGQLTQGGSINMWLQLGKRLNIDETGLILLRILSQRQNDEIAKEFVKLKSEMRHETEPLISSSASNQQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEK4</accession>
    <name>A0A0N5CEK4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEK4"/>
    <dbReference type="STRING" id="174720.A0A0N5CEK4"/>
    <dbReference type="WBParaSite" id="SPAL_0001629200.1">
        <property type="protein sequence ID" value="SPAL_0001629200.1"/>
        <property type="gene ID" value="SPAL_0001629200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="194"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="412"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001629200.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60637" checksum="73F6E7ECC469A861" modified="2015-12-09" version="1">MAKKKRIIMFIAIPTTKKLQEVIFKLTNLFFHILFTGSMPQRPMGTGMVRGNVNKVTFNVRQPPTEAPNNTKPFMSNRTSPQPSSNTPQNNMRGVERMPNGPSRNNFKGGFKNNFGGDYNPIDRPCDVIFEEDRKNAEYYSQLDEIDDEIIVSGAGNVPKCYETWEEANFHPTLQNTITKSGYAKPRKIQAFAIPIIANGSDLIGQSETGSGKTGAYLLPIIDEMLKTEWKSGRRVPFALIIAPTRELVLQIHEQARKFCNGSQYGCAKLYGQISNSYLQRELDGGCDILVATPGRLTEFLSKGHVHLNKLHYVVLDEADRLMEYNFAKEVTNILQSPSCVPLASRQNLLFSATFPPELQKYFREWVKDNAITIRNDKSNQVNKNIIHTFICVEGMNKNRMCADILVAENEEAKKHGMSLRKTLVFVAKKKTSDMLAFLLVNNGIRALSINGDRCQEDREKALNELRSGNIDVLVATDVAARGIDICGLDHVIIVELPDDFMTFIHRVGRTGRIKEGEATTFYDPKKDYILANDISNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF45</accession>
    <name>A0A0N5CF45_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF45"/>
    <dbReference type="STRING" id="174720.A0A0N5CF45"/>
    <dbReference type="WBParaSite" id="SPAL_0001648300.1">
        <property type="protein sequence ID" value="SPAL_0001648300.1"/>
        <property type="gene ID" value="SPAL_0001648300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF2">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001648300.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37145" checksum="04586E40569267E7" modified="2015-12-09" version="1">MEKELVKEIHEFLKNYGNYADQYMLDYYIEKQWSSIPKEWQSFFESKKDTIDDIALYILDITNNKFDNEAPTSLLKIKNDIKNILNTLFTDKSFYQTEKCDFSEIPKSLLTKIKQKKLHELQYLVPLIKHLYTVSNSSFNQIVDYGAGIGHLSRILAYCLKDYVDIEISTVEGNDKFVEKSIELDKIFENKLKHLEKEVSNFKIERESKLISDNNDFSSQNKSSSCKKLILGLHTCGDFASTLIKHYYVNTEAAALVNVGCCYHKLNNGSDMKYRQIYDATEDEVHENYSYPMSNEKDIFPQLSYAARELACHGLRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF77</accession>
    <name>A0A0N5CF77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF77"/>
    <dbReference type="WBParaSite" id="SPAL_0001651500.1">
        <property type="protein sequence ID" value="SPAL_0001651500.1"/>
        <property type="gene ID" value="SPAL_0001651500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001651500.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12237" checksum="F5131357B7514B6F" modified="2015-12-09" version="1">MFLILVECTTPIQVSGNNNDVRITSTVTTTADGDTVAVVTCTVRDVNANNQNNQPNQAWMNENGFGWFTTPNGDQTMVRTYKCNHETGSWYIGDTPTDAVRFVRCADREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFB7</accession>
    <name>A0A0N5CFB7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFB7"/>
    <dbReference type="STRING" id="174720.A0A0N5CFB7"/>
    <dbReference type="WBParaSite" id="SPAL_0001655300.1">
        <property type="protein sequence ID" value="SPAL_0001655300.1"/>
        <property type="gene ID" value="SPAL_0001655300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001655300.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32717" checksum="D754508915460A0C" modified="2015-12-09" version="1">MGRDNSKYVSKRKYDSSRKYSRSSDSDYEYKRHRRHRSNSNDSRSKVDYKKRSRSPKMSSYDRKRNYDKISESGDKWGKPEHYKEESESKAPVEKDKPNFGTSGKLCEDTNTFKGVVVKYSEPHDAAMPTVKWRLYPFKGDEALPQIYIHRQSAYLIGKDRKVADFPIDHPSCSKQHAAFQYRNVKTSTGSRKVLLYIIDLGSTNGTFLNGEKIESSRYYELKEKDVLKFGFSSREYVVLSENMCQKDVSEDKEDSDDDLDVDLTGVDDKIKQENSSNDYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFI6</accession>
    <name>A0A0N5CFI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFI6"/>
    <dbReference type="STRING" id="174720.A0A0N5CFI6"/>
    <dbReference type="WBParaSite" id="SPAL_0001662300.1">
        <property type="protein sequence ID" value="SPAL_0001662300.1"/>
        <property type="gene ID" value="SPAL_0001662300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019546">
        <property type="term" value="P:L-arginine deiminase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271:SF2">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19420">
        <property type="entry name" value="DDAH_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001662300.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31106" checksum="46A27F3C2317EAEB" modified="2015-12-09" version="1">MSSVGLLLQKVLMVPPTHFCVEYSINPWMGGVVDKDKAMEQWKNLKKIIEDEGVEVLTLEQVKGLPDMVFSCNAGIIYKNKVFMTKFRHPQREGEEKHFRKWFIDNNYEIVSDLNEYYFEGGGDAFFSDYKTLWAGYGERTKKDVYKNITALGMNEFDIMTCELIHSMYYHMDTCMAPYSETACLWYPPAFSVESQEKIIKKLPNSIAVDDDEAKAFVCNSICIKNTIISPIGMKQSTKNKLLKQGYNVREVDMSEFMKSGGACQCLVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHA7</accession>
    <name>A0A0N5CHA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CHA7"/>
    <dbReference type="WBParaSite" id="SPAL_0001722500.1">
        <property type="protein sequence ID" value="SPAL_0001722500.1"/>
        <property type="gene ID" value="SPAL_0001722500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001722500.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25442" checksum="C1B06A7B4182AF2C" modified="2015-12-09" version="1">XWTVVRLAVHLINKDCTVANEMNNGNNNCFKVEKGYKSTLLAFYNLNKNDINARKYLYNEIPEYYWFDLKTREWKLRHRQRRTIGRIFTVSPMNVELFSLRQLLLHVPGATCEGDLKNINGVQWPSFRDAAISRGLLDTEDNYNELFEEACESAMPNMLRNYFGLMICYWPSFTRHYDTFIRFKNYLIEDYLMKYNGNEEKAEAQAIFDIRNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI49</accession>
    <name>A0A0N5CI49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI49"/>
    <dbReference type="WBParaSite" id="SPAL_0001751100.1">
        <property type="protein sequence ID" value="SPAL_0001751100.1"/>
        <property type="gene ID" value="SPAL_0001751100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035291">
        <property type="entry name" value="DUF5354"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17305">
        <property type="entry name" value="DUF5354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895912" evidence="1">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001751100.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17006" checksum="85BDF57D78AB705B" modified="2015-12-09" version="1">MSCSVNAPMKFVVLFISLISYLQTSHALTCYESKDDGSIIPVRNDTWKYCAIVPALNTAYGTSDGRRFGLGPQNDWTEAYDSTFAYNDNMYKVLTVCIFEKYDFSNINPKMNYGQSVEYIFRCVCNYDRCNSASTFHGYINSMKRDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI61</accession>
    <name>A0A0N5CI61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI61"/>
    <dbReference type="WBParaSite" id="SPAL_0001752200.1">
        <property type="protein sequence ID" value="SPAL_0001752200.1"/>
        <property type="gene ID" value="SPAL_0001752200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895971" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001752200.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11266" checksum="7D26F8E81B12CED7" modified="2015-12-09" version="1">MNSLSVVIFIAILINILFGYKTNCTRDIRIPCAVYLTPSEDAYRKLLQTIDPYDKLNYGIGLGPYDTDWKKIRKENQAIKKLGDQTIVSQLIIGVNPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CJ10</accession>
    <name>A0A0N5CJ10_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CJ10"/>
    <dbReference type="WBParaSite" id="SPAL_0001782100.1">
        <property type="protein sequence ID" value="SPAL_0001782100.1"/>
        <property type="gene ID" value="SPAL_0001782100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001782100.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15270" checksum="55506C64C589A87A" modified="2015-12-09" version="1">MIFFAIKGKLFIKGRCCHCRSIYDKEIKTDSNSQLSPTGVHHRECEKAIDSRLLSTKAYQKFLKYIANFGSSNDINTLGFTTKKNIFVFAQFKNSYSKRKRIFDSKVFLEELKLLNNETCFHNFGDDVGIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2N6</accession>
    <name>A0A0N5B2N6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2N6"/>
    <dbReference type="WBParaSite" id="SPAL_0000034125.1">
        <property type="protein sequence ID" value="SPAL_0000034125.1"/>
        <property type="gene ID" value="SPAL_0000034125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000034125.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8472" checksum="F550BB0BE1F61C59" modified="2015-12-09" version="1">MRSLNSWFIIVITTVERLEIKSCFEELVFDIIYNGCVSKYICDNKIVKGTSILPWSTKRYTTTSKTGIASVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B342</accession>
    <name>A0A0N5B342_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B342"/>
    <dbReference type="WBParaSite" id="SPAL_0000049300.1">
        <property type="protein sequence ID" value="SPAL_0000049300.1"/>
        <property type="gene ID" value="SPAL_0000049300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893812" evidence="1">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000049300.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37703" checksum="A1E74DC00C68FC65" modified="2015-12-09" version="1">MKNKISKLTLILYLLLNVFPTNSINKAMKRYSINCENSSNGKKCVEGFQNVTTYYRINSRYKLNFCTIQKNLSTVLKAISCYLDHPKLQKEKHQLVSDFWIRSVCKSRNKIDSLKKEAIRFSDGNIDNFLTEYKSIVIVRNPIERFISAFTDKCVLRYTESKGRCYGCFEDLSCFINTLYKRLLKQVNNPKKVYKATYVDRHFYPQSWYCQLNNYHDMYKVFKINPENKKSVIKFYKNFSEYLVSQGVSSREASFIEKEGMKKYTGHTTFHTKSRKIIKKELLENVKLMDKLIRIYYYDFKIFNFKLPKKSSRFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3C9</accession>
    <name>A0A0N5B3C9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Wsv289</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3C9"/>
    <dbReference type="STRING" id="174720.A0A0N5B3C9"/>
    <dbReference type="WBParaSite" id="SPAL_0000058025.1">
        <property type="protein sequence ID" value="SPAL_0000058025.1"/>
        <property type="gene ID" value="SPAL_0000058025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000058025.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22218" checksum="59297BEBEF02E952" modified="2015-12-09" version="1">MKSDSSDSDDFLFSKKRVKFGSYTFVEPSFNFVMPRLLCCDGAHKEVGSYGRVNLDDKKDGDRGRYDVVINGSELLSYLTTKEKICIFEVSSDRVEESKDDFRREHIESANYGRVNLDDKKDGDRGRYDVVINGSELLSYLTTKEKICIFEVSSDRVEESKDDFRREHIESAKLIYYRNLSHIGVPVYPLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3E1</accession>
    <name>A0A0N5B3E1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3E1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3E1"/>
    <dbReference type="WBParaSite" id="SPAL_0000059200.1">
        <property type="protein sequence ID" value="SPAL_0000059200.1"/>
        <property type="gene ID" value="SPAL_0000059200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20015">
        <property type="entry name" value="FH_FOXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000059200.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50735" checksum="AEAEE844D69F9880" modified="2015-12-09" version="1">MLTTSGSGATGLTLDANNLYQTTSVSMTGQDYTTSMIPSYTTTALNSYNSYAYPYNTAATAYATPYVTTSGNGVHMATAYGNFQTGNGTLISGVQQKTTPNSLSSLDSCSNFAVNENNFVSKLPCKPGEQNMTAADFARIKKNGYGHAKPPYSYISLITMAIQKSENKMLTLNEIYNWIMDLFPYYKNNQQRWQNSIRHSLSFNDCFVKVPRTPDKPGKGSFWSLHHLCGNMFENGCYLRRQKRFKLPNREKSNRKMQRESSNGSQSQTYSEGSDNELKGEILNNSDDLQNSSNITASSSPTSTTDISSIHSRNNSPNQIIKQESSSPIINGINNNNSTTSLVSPTSFITTSSPSIITSVGNLPSMSASYIPYNGTSFTNIYGSQDFSNNVPNQSAFSINTLFDGKNILDPSSFYTTGNGNQFNMYSNQGTGNNNNYSTYQNTYVTTSTPNLEQRIIPNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3F3</accession>
    <name>A0A0N5B3F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3F3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3F3"/>
    <dbReference type="WBParaSite" id="SPAL_0000060400.1">
        <property type="protein sequence ID" value="SPAL_0000060400.1"/>
        <property type="gene ID" value="SPAL_0000060400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893689" evidence="1">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000060400.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="22751" checksum="CD1390EED8AD705E" modified="2015-12-09" version="1">MLHKGYFFVIYFITLSSTAYGCMSSKPTDPPVVPTTTITPPTTTTASDTCQNQDNKAMVYMDPSVSAAANAAIAGSKTGTPCDKCANTQYFDPATNDVFAGTDAINTYQCPDAQPLCICDETECYKETDVSVSVSLYPYCASASDCAAYAILSAQADTMGVGGADGTPVWTPDGTVDANFNFLPVSSGKFMKVSAISCGTCPVSLTDPSCLPITPTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3I7</accession>
    <name>A0A0N5B3I7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3I7"/>
    <dbReference type="WBParaSite" id="SPAL_0000064000.1">
        <property type="protein sequence ID" value="SPAL_0000064000.1"/>
        <property type="gene ID" value="SPAL_0000064000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000064000.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19719" checksum="BB8599D1D583C198" modified="2015-12-09" version="1">MGILAFFGPQDVKESLGDKIISNKLTVKDAKNHFPIMERILPDDEDDRIITEDLFKNYLSSFTTVNEAFDLVSEFMARASSECFSHLVSDDEFGDHCKEIYISFNRFIKRKLNPSAEGIDEGIPMDTTPATGTTKKRPILKARTFSSRKERVSTITPTVAEQSQVPCGCIYHKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3S1</accession>
    <name>A0A0N5B3S1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3S1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3S1"/>
    <dbReference type="WBParaSite" id="SPAL_0000072400.1">
        <property type="protein sequence ID" value="SPAL_0000072400.1"/>
        <property type="gene ID" value="SPAL_0000072400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000072400.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28654" checksum="97D50D99F260F96F" modified="2015-12-09" version="1">MGNYFINNFSKTAKKIDFITYFLSEKPCNVGNVIEGCRKKMKNNKNSHCRKKKNLLNCLVLLKKEENLNDLLRPKIRRNNKVESLNNDLLCNPLSTPLYYGSKNNNDVIDNDINKKIIKRFCLVNIDDQNKFNCRCCILLSSAKFYGKVKVGTLFIQKTHLIIRYFEFKKLTYQYTIYPLTELLALKTKYKNKKILTFKNYSFEMIFGEQNIGSVKFYILTNFNFVMETFKRIPLLREKLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B456</accession>
    <name>A0A0N5B456_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000085800.1">
        <property type="protein sequence ID" value="SPAL_0000085800.1"/>
        <property type="gene ID" value="SPAL_0000085800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000085800.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21321" checksum="7F0D83ACD32CF1D6" modified="2015-12-09" version="1">XDLSEYYEKSIDLPDTFSFNDIKRLWYYYCSKCEDKPNHCQHGGYYKDSSCDECKCPLPFIGDKCERIISNEGCDNMQHFTAFPNINYNSILNISRDCYYSIKSKNGKKIQFDIFTLTLSRKNDCYGGVGLEVKYREDKGAEGLLLCDNYKNIYFPPSREIYLNFAGDGIDSVRFSYQEVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4K8</accession>
    <name>A0A0N5B4K8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4K8"/>
    <dbReference type="STRING" id="174720.A0A0N5B4K8"/>
    <dbReference type="WBParaSite" id="SPAL_0000100900.1">
        <property type="protein sequence ID" value="SPAL_0000100900.1"/>
        <property type="gene ID" value="SPAL_0000100900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000100900.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43747" checksum="6746E95A594EA4BA" modified="2015-12-09" version="1">MDLKNSEDLMNSNIDSNTKNIVKRVSTMCTIESFSTCVSVFKPCGKYDNSFGYTCNVNRLCEKCRVQKGTIENGHTFNFELDSKVKGSLGIHPYGRGGDSKDYVSLSLHFKEFSCLMITALCKFSISNVDGKEEYKSIIGVEEFDENKNSFCLQKFINRSDLLKRKSKLLPGDRLTVCFEIFYLCDDINTYGLSKATPIKEPLNIFLNDMSRMVDSSEYYDCIIKVGNHELNVHKCILDARSEVFRSALKRKRVEPESNIVEMNDFRLGVVKDMVNYLYTGKSPRIDEIATEMLEIAEKYKLEGLKMIATESLLRSLNVENVCEYLEKSELYSAEVLKEFCVRYIYLNAEEVVKYEKWRKIVNFYPLLLEKIFNVTAGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4N3</accession>
    <name>A0A0N5B4N3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4N3"/>
    <dbReference type="WBParaSite" id="SPAL_0000103400.1">
        <property type="protein sequence ID" value="SPAL_0000103400.1"/>
        <property type="gene ID" value="SPAL_0000103400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000103400.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26328" checksum="410BC59D4AFF1426" modified="2015-12-09" version="1">MAINSSSGWTSITLDPGYTSYLLSFQTMNMIFGSIGIIINILLIIILLSSEFFRCYRRLILLLAIGDLCNCIYVFMQGYERKEIYLHAFKTGYVKNQTYWSCALKVFDWMGLLGSLIPHIVTFIMSIERTVAFKYPLLYERYFSKGDVKACSFCCIYVIINMILAFTLAYLHRNVPSRYFCGRKVSYTYAYISFIYGMNVFGYVSCFIVTLSIMVHLKLLIRIDKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Q7</accession>
    <name>A0A0N5B5Q7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Q7"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0000140300.1">
        <property type="protein sequence ID" value="SPAL_0000140300.1"/>
        <property type="gene ID" value="SPAL_0000140300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000140300.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="63657" checksum="49D462F61EA48BD2" modified="2015-12-09" version="1">MNTSIVSDDFSLEPEIRGRCYTWPMPHVISPINEMDPEIDDCPSSITSFVTYLHHQTPDTPMTGYNLSGDMISNYGSNHSIATSCSIHNGSSNSVDGVNTINNVGSNNQPTTILEHHQMPMKKKRIRKRNPDAVSQKKPNPWGEESYSDLIAKALECAPEKRMKLNEIYQWFSENIPYFNDRSSQEEAAGWKNSIRHNLSLHNRFMRIQNEGAGKSSWWVINPDAKNGRSQRRQRDRSNTIDNSKPTIDKKRRGAKKKSEHLNVMGLRTSVQSGLNNSLYGSTTSSLTHETFNQDQDDLMSANTFDSFTGFRQRAESNLSVQGNVNGVSPTLDAFDEYDTYPCYDMSTTNNGSQVGDILDRTNQMQLGDGGMDPNGYRMNMGTGMINSSMKPIKEIIKPGEMTHQPPPSYHELNSVRNGTSMQQSPLLRTQLNGPIDKNSPSSMPPNGNNPMSPNGGYYNPQYSSQMVHQQMWMSSPMAQPPPAHMSGHMMQHNTMNQLPHHQMQQMNQMQGNNMLSCGAQSGNELPQDLQNLNMLETTQMTEMDFESIMRHEISINSNAPINFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5R1</accession>
    <name>A0A0N5B5R1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5R1"/>
    <dbReference type="STRING" id="174720.A0A0N5B5R1"/>
    <dbReference type="WBParaSite" id="SPAL_0000140700.1">
        <property type="protein sequence ID" value="SPAL_0000140700.1"/>
        <property type="gene ID" value="SPAL_0000140700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893819" evidence="2">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000140700.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="43171" checksum="7D008546220D7D22" modified="2015-12-09" version="1">MLYSKSILIFSLFLLVGTISTYHLKNSDQDNLANHDNLNHEYRAIISNDVNKLPSQNFQKESKTDVVLREKRQAERVRARRERQRKERMRRRKLQQERLRRQRQNQKMNRLRQQRKRQEQQKKRRERERKEIARRRRQRRMRQEAERRRRRLERIRQEQERQRIEEERRRSSTTTTTRARTTTRRTTRRTTTVRVTTTRPPTTTESHVTTTTVGQLVTTAESNATTSSEKQTISTKKQTQVTSTGKSDTTHKEPTQATSTGKSDITSKDNTDTTPNASSPTRSGSALGAMSEDERELYDEEKTEKEEDDGYDEEYSDDTEDDEDDADNNDGTEDDENEADDEDYNDGTEDYEENEDNGYVTQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B649</accession>
    <name>A0A0N5B649_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B649"/>
    <dbReference type="WBParaSite" id="SPAL_0000153800.1">
        <property type="protein sequence ID" value="SPAL_0000153800.1"/>
        <property type="gene ID" value="SPAL_0000153800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000153800.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12951" checksum="F72DA5567D14429B" modified="2015-12-09" version="1">MNKIYESIPDTIACSDSSILIILLIFTGFGIFFLYLILHFFCSLFIISSIDNNELGQIRIKQNRMEKAFSNSILKRDVIIEMENYKPNCWRENYTCTTYKPIVQTKKCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B693</accession>
    <name>A0A0N5B693_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B693"/>
    <dbReference type="WBParaSite" id="SPAL_0000158200.1">
        <property type="protein sequence ID" value="SPAL_0000158200.1"/>
        <property type="gene ID" value="SPAL_0000158200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893822" evidence="2">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000158200.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40000" checksum="0C195EF191A30828" modified="2015-12-09" version="1">MSSKFFILLLLIFYQCNTSYGKSMTFNIKNKVKRSLNNLRVIPKLDKFYCGTDGLVSFLAENKLTHSCPSRYNQANMCCYEHDNCYSEQLGQEYCDEIFCSCLSQYVGEDGKDSKCVSVANYFCETVKDFGSYAYSASATSNSSVEDNNDNSQRNDYETTATNDELTTTIAPAVTSTILFHFNECRDEKEIIVEYCISKFDECKENDKEDKELCNGNFCECISNRITNNEIEYLQSTCKQELINYCPVLSTFSSSNVDRDSFNLKDTLWNLFLAYSNFIYLGLIIVFIFIYLYVKGYLHTYPLKYEQAPSELSQVGILSDLTMNMTDVTLLTPTKLRPSSSASLQVQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7F3</accession>
    <name>A0A0N5B7F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7F3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7F3"/>
    <dbReference type="WBParaSite" id="SPAL_0000197900.1">
        <property type="protein sequence ID" value="SPAL_0000197900.1"/>
        <property type="gene ID" value="SPAL_0000197900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000197900.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47513" checksum="6E2CD1DEE38C0FAA" modified="2015-12-09" version="1">MGETSTEYSQLESLFSVVRPPSGSQRSRLESLPENRSYTYGFPISEYDIREAVAKEAKARKLWRYKAIKNMQIDNIEHSNCFHYVLESFTEQRSIAETTEPYTAGSHIDSVGYIERHQDLEGVPTSSDARRSPIQDNGSVNPWEYIIEPSTDFVSQTRVIELPGSSHLASCTNCSAEGQQHCFHCRGNGTDKCNYCRGTGMKAGVAHPAIYTHPMIGTFPHADTSVGYPGSGSVIVRPHDKRQSYAAGTPVHFMMKAGLPPPGIGQHDLCIFCRGRGIKDCTQCKGQGRKNCVTCNGTGNVRVYTKLKVFFAVERSDFFTESEIPQHLFHFATGDQIFYECHPYVLPLKKFEAKEVNEGSRKLCAEHLQRSLGSTKMLKQRHFVDAIPVAKVYYTMGKNSGVFWVYGKEHLCYIPKKSSSCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B870</accession>
    <name>A0A0N5B870_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="7 15">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="7 15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B870"/>
    <dbReference type="STRING" id="174720.A0A0N5B870"/>
    <dbReference type="WBParaSite" id="SPAL_0000224300.1">
        <property type="protein sequence ID" value="SPAL_0000224300.1"/>
        <property type="gene ID" value="SPAL_0000224300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="16">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000224300.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27344" checksum="5E1DF59CD620DE47" modified="2015-12-09" version="1">MDEGNVPQYSILLPTYNEIENLPICIWLIEKYMTEAKLNYEVIVIDDASPDGTLEVAKKLQKELGENKIILKPRSGKLGLGTAYVHGIQFARGDFVVIMDADLSHHPKFIPQMVKKQKIRDADIVTGTRYVGNGGVCGWDIKRKVISKSANFLAQFLLQPGVSDLTGSFRLYKKEVLSRLIADSVTKGYVFQMEMMFRAKKLGYLVEEVPITFVDRFYGESKLSGSEIVQYAKGLLYLFATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S8</accession>
    <name>A0A0N5B8S8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S8"/>
    <dbReference type="WBParaSite" id="SPAL_0000245100.1">
        <property type="protein sequence ID" value="SPAL_0000245100.1"/>
        <property type="gene ID" value="SPAL_0000245100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000245100.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="74850" checksum="8CEF65365394E3ED" modified="2015-12-09" version="1">MKSGKRSSTSPTKELDDDIGVKKSKIRKSEEFYENFEEGNSIQDQQSDNRSNSVEKSSNEEDVNHDYLSDNSVDKEHNKFLEESFIKDELLNTRIILKLDNKELYDGNESEFEFDDASRNSHSTDQDIEGIVEEKYSDGEMVLETTRKQYYEGNKVHNESDDSQSTSHSTDQKIVEVENSIQEIVFETTNKKLLEENEANTEFGDSQSISPSIERNNIEEENSRDFMVVELNEREPNEDSEVNTESVDSQITSDSTDKIVDEKKHLDEKMTSQSTNKDQYDADESDFESDKSPSSLFSTDQNSDEEENSDQKMILEPTMKDPPSTDQNSDEDENSDHEMILKPTPKVSYRENIIKSDYYPSSPHSIDQNNDEKENSNQEMILELTTRESYRRNENNIESDYSQSNSNWIDRNIVEEEHSVEQIMSDDANKQGYEEYEMKFVSESDDSLNVSHLIHRKVSITKNDVNDEINRKLDDRFPEHSLPPQTIIENDEGNDVNDKECEDEEDEEEGNKTNYPKATPYGLYIYDVEHDDMKANTSTDGTVTITLTNSIGTNIMAEIIEKMPTDPTEDWDLTQERMMNAHYFMNTFEGRKTRPDKDVLIAVLMYGSYFTGYSIESNIIDRIVTVKLFGCENQDLNVRTFRRTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9G0</accession>
    <name>A0A0N5B9G0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxisomal biogenesis factor 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9G0"/>
    <dbReference type="STRING" id="174720.A0A0N5B9G0"/>
    <dbReference type="WBParaSite" id="SPAL_0000267600.1">
        <property type="protein sequence ID" value="SPAL_0000267600.1"/>
        <property type="gene ID" value="SPAL_0000267600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026510">
        <property type="entry name" value="PEX11C_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000267600.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23837" checksum="8BC7980C70E3C6A8" modified="2015-12-09" version="1">MEDITLQRIVRTLSTYPGRDKFVRSLYFGLILLADKVGGTTSESIMILAKQLSAARMIFRQFNHIGMYKACLDTWKLLYEAKDKIDYSLGAGITGIYSVYGIVELIAWIGDAKLIAVDSAKYYKYCLYLWICALITGIIKGIRQIFIKYYKRKDINEVREDIITTVGLTSDLIPAINSLSFPFLWSQKLPTKTTARLSLVASLIGLYKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA07</accession>
    <name>A0A0N5BA07_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP synthase subunit s-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP synthase subunit s family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA07"/>
    <dbReference type="STRING" id="174720.A0A0N5BA07"/>
    <dbReference type="WBParaSite" id="SPAL_0000287600.1">
        <property type="protein sequence ID" value="SPAL_0000287600.1"/>
        <property type="gene ID" value="SPAL_0000287600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000168">
        <property type="entry name" value="Distal membrane arm assembly complex 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00076566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000287600.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51800" checksum="E7FEB2CC16D18338" modified="2015-12-09" version="1">MNNAIYLVNTTKILYNPSRNSIHFWKQFKRWQDLDKEYKKEKKLEESKKNYIRLNDGFYITPERETDVMPKKDTVDMTRRESGAMAMELMTKHTQMRYLDHSLDNIKRYKAYEHFQHLQYDQRFIPERLLFLGPDLAAAYFIVHRGGTVKFFDDNTWIRRDSKGRYSLPPRRVPGLYLEAIDASNTELMFEGFDNFYDLSKLRLLSVSNCKYVDDWTLSRIGTMFSESLEMLDLSNCKKISPKGIMGLRSLKKLKYLRLNGLNDPQGMAKATIMLEESIPGLVVIGVDYEAALEGFQKDKMLLQHERASLDAKGNIHIEDDKGELYYIKGCVNERPAVDDNDLPIITNTIRVDVPKMSDVEFEELDRLSEGKLRHLLVGSPSAYSWSDAVESILSFEEKYKLKRGEIVDSKLLPSSKRQDVIKEVEKLEAAKLEKVESNVKQLKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAV4</accession>
    <name>A0A0N5BAV4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAV4"/>
    <dbReference type="WBParaSite" id="SPAL_0000316800.1">
        <property type="protein sequence ID" value="SPAL_0000316800.1"/>
        <property type="gene ID" value="SPAL_0000316800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894229" evidence="1">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000316800.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25779" checksum="7BFDCE9B97471144" modified="2015-12-09" version="1">MIINIKIFFLLLFIVFPTVFTNSLRKRKDLENQKINNITTSNLTTDFYSTTLPYTNESENITILMENSTFVTLISSSSTTQSTSLSTSNISSQDINIEENEKIVELSPLMDNINKNINIENEFQKFFSNSNGIFNIEEGIFAKSSCYYEGTTIIEDGIKREMTEEEMNEMAEFITKTVKFNSEWRYDEEINDWVKVDETITSEKDSWSEVPCFCKYCLTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBD5</accession>
    <name>A0A0N5BBD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBD5"/>
    <dbReference type="STRING" id="174720.A0A0N5BBD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000334300.1">
        <property type="protein sequence ID" value="SPAL_0000334300.1"/>
        <property type="gene ID" value="SPAL_0000334300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000334300.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="72527" checksum="03F0CF9B5758871E" modified="2015-12-09" version="1">MVINCDKIVDAKYRIKNNDLSCDFNECKPWPNDYKSWLDPNKKSPPCEPINKNLYYYIKDDTIFVRDEVKSKINCNYTCYSKRNYEKIDIAKNVAVNSKAILECDVPWVKCYNEENEKVYENIELVLKKLNEKFEERRDFLKPGYSLPNDIKKYSLHVVVIDSLSYYHATRALNQTRSVLLNHGGIELKYLNVIGEDSIQNARGFLLNKNSNNVEDNSLGRPTKINDWGSKDPCNVALDNTTYIFDYYNKMGYVTLYNDNSGMETFQYYNCVGFTKKYAHHSTRVRQFLNFFDFNRGEKIIWDDFKNKCSSMTKDTFKYHEDFLKRYQNQPTATLTWDTYSVHDDINDIFEQDEYLSEYFERNSKYHKDSFLIVMGDHGYRTGPYMNTEVGKYEHSNPYLLIKPPADLLGNEELIGNLKANSIKHISHLDLYATFLDILTEGPKNNFKNLKPYDLSNVVNDTIKGLSLLRPLPDENRSCYDMYIPSKYCLCQPKYEKLSRWQSREIYNRLEEVFIKDINKQLENDNLKEMCSQLTLSNDVKDYFIVKTSRGKNTTLYEVSAITRPGKGSFRAYYNQNFTLTNDIIRTNMYRDQAEVCNKESKYRKFCYCKILLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC40</accession>
    <name>A0A0N5BC40_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC40"/>
    <dbReference type="STRING" id="174720.A0A0N5BC40"/>
    <dbReference type="WBParaSite" id="SPAL_0000358900.1">
        <property type="protein sequence ID" value="SPAL_0000358900.1"/>
        <property type="gene ID" value="SPAL_0000358900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="6">
        <location>
            <begin position="58"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000358900.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47932" checksum="366C5A7962F35F83" modified="2015-12-09" version="1">MKFLKPFPLLKKNNYALFCSKNRSIELPESKPSSHEASFRKGPGGRTSFSGNVITIFGATNPFGMSVINQLAKTGNQLVIPYRCEPYWLRELKIPCEVGQILFVPFELKDEKSISEAIKYSNIVINMIGTRIETRNYNFFDTHVEGAKRIAKISRESGVDKLIHISALNASTNPKGSLIPTGSKWLRSKGQGEIVVRDEFPKATIIRPSVMFGEEDHFITYYVSRFRKTFFDTVYLYKAGEETYKMPVFMNDVSKGIRVAALDPTTYGKTYELTGPHCYKLSELIDYMYKKAHCLKKFSFNYKRHGFPDPVFKSYMVACKLWEKFFKCDTPINKEWMEVVEGTSDVLTGGLTFKDLGIHRITEFEYMGGLLASRRSFFRYYEEQLHDLPNPPLPLRSPPIIDKNFDPQNIITVTKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCP6</accession>
    <name>A0A0N5BCP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCP6"/>
    <dbReference type="STRING" id="174720.A0A0N5BCP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000379100.1">
        <property type="protein sequence ID" value="SPAL_0000379100.1"/>
        <property type="gene ID" value="SPAL_0000379100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="87"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000379100.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48135" checksum="02BD1EC601D6D0CB" modified="2015-12-09" version="1">MESQISLWEENNMGRSIPPECLLAYNSTYEKFKTVQVGTQNFPINITNCLPVCGFCAVSVPDQTYTFITMLINGVLLPFTGVLGILGNITSAYVYSRPAMKSSTNFYLCALASSDCFIILAALITFWLDIFRNHSILLHQFYGIVVPYVYPMCHVVQFCSVYFTVLAATDGFIQVCLTQKIYSWVSRSSVSIKAVIFVVISSFIYTLPRWLEGIRIGCWHGVMEEASYEICQNKMASQPWFTQTYQGFLVNVITVLIPLTILVFLNICIIGASAMVKSNNTSSRSSGSDNIALILVVLLFIMCNIASYLLNAHEAILLNLLGPSINYLIDTSNMLTVFNSSFNFVIYYVFSSPFRRTLHQYFGSHVNCNGPKHFYNDNNLSDNEIVLSTNKVVAKNVNDDEISISFEAKRLDTISRISIIDGELKDVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD32</accession>
    <name>A0A0N5BD32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUEL-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD32"/>
    <dbReference type="WBParaSite" id="SPAL_0000392300.1">
        <property type="protein sequence ID" value="SPAL_0000392300.1"/>
        <property type="gene ID" value="SPAL_0000392300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000392300.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13575" checksum="7392505C888068EE" modified="2015-12-09" version="1">MCDYVFDIFTHCSCGKDEVEIQTINPQQQQKHFEKIKKKCNKFPHRVKAIGVTCLSRVVYISIKHTCPQEIKTLDIDSDNCILTEQPGNGRYGYNCYETKHLKEQYQHYQLPKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE24</accession>
    <name>A0A0N5BE24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA_lid_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE24"/>
    <dbReference type="STRING" id="174720.A0A0N5BE24"/>
    <dbReference type="WBParaSite" id="SPAL_0000425100.1">
        <property type="protein sequence ID" value="SPAL_0000425100.1"/>
        <property type="gene ID" value="SPAL_0000425100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000425100.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11109" checksum="D0252A1E200003D2" modified="2015-12-09" version="1">ERLRYTPLGWANTYELSDADLRVACDTLDAVVDINAAKRSNVDPENLPWSTFQTLLSQCIYGGKIDNKFDQKLLDCFINKFFYRRDSVIVIFHALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE41</accession>
    <name>A0A0N5BE41_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE41"/>
    <dbReference type="WBParaSite" id="SPAL_0000426800.1">
        <property type="protein sequence ID" value="SPAL_0000426800.1"/>
        <property type="gene ID" value="SPAL_0000426800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000426800.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48564" checksum="2AE241CA64812661" modified="2015-12-09" version="1">QFSSIKNPTIFFESLNRDGTIYANDLNELINTIIKYNIKVKLKIDIDCPEFEGQCENCTDTISFFSSIKQYVTAARSRVIYYNQSPRSIEILKIFKNLSTLNLKFRLDGFNFQSIVVGVQKPRDLELQKLNGLKNLKLEYDRYYQYRGPDASNPYYQSLEFICSIMPRSVKVLQFKNIRDMDDVIAKMITRYMQNIKLLNIECLSYKERDNLVEEEPKKEVLEEAKNQLYSITFRHTDLRPLHSYIQRTSKLIATLFEQDCNSDLVEQIATFHCIMRMPKDLTAAFFKHLEKEKEVLCKESFHNWATRNKTSIHQRLKKKDTPKIIGLSHWTIKALIGNVKLSTTMYLDSCSGFNYLSMKSWKDLGEPSLDLLDTVEIKDVGANIISCLGALVIPVVLDNIEHTCTHKLKIPQFKVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFS9</accession>
    <name>A0A0N5BFS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFS9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFS9"/>
    <dbReference type="WBParaSite" id="SPAL_0000484100.1">
        <property type="protein sequence ID" value="SPAL_0000484100.1"/>
        <property type="gene ID" value="SPAL_0000484100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000484100.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="55078" checksum="3F6000B9D107C1DF" modified="2015-12-09" version="1">MSLNCIICTKPYDNGEHALFSTKCGHVMGKSCLDEWANGNVNQSRFNCPVCHELILISDCHQIFNLPIELLKIKSDDSKDKYLNEDGILKDCLSGKLKKGSTFFVEKGYTELKGNKMIHFSDTHNGFILVAGIVNYELGEWKYEWGTDNRRSFVQIFNGTDIFYSEDFRSVPLTAVAFNKFREDAVEFCVGFKNGYLMNRVLSLPNKDFGVPNKSVLINEGRKINSICFLEKKKVVYSVGECNILSISTDNFCVKENWLKNTNVRSKGVTNLSVINNRVLLGVMYGCIYVFEKYKIPYVLYSDEFKWVKSYTYDSTTNKILIFKFVPYCLWDYFETDFSEIRDEMLLSREVRGISRISKYDNEGCRREEYTTYLVQDFQNTTYCLPGNFNTTLISMEYCGKYFTHSFLPDEGNNMLQLHFVNDTFNVVGKKIIENLDHCIGIFALKKSYALSSNVVKIPIVLIFCEEFTMLNCYTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGB8</accession>
    <name>A0A0N5BGB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SWI/SNF complex subunit SMARCC2</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BGB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000502500.1">
        <property type="protein sequence ID" value="SPAL_0000502500.1"/>
        <property type="gene ID" value="SPAL_0000502500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="86"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="589"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000502500.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="87058" checksum="ED835145C842C779" modified="2015-12-09" version="1">MRKSGIKRRLQENGSEIMEDDEDSRNSHGVVPVNVPAGKEKDSEFQPSKNSKLTNLDDEVLVNGIVKDPVKGDNSQAQAIEQTHYIIVPSYASWFDYNSIHINEKKGLPEFFNGLNKSKTPEVYLYYRNFIVDTYRLNPFEYLSATACRRNLSGDVCAILRVHQFLEQWGLINYQVASESRPTPVVPPSTAHFMVLADTPMGIQPLSRPGNSIKKEEVVETPAEKTNKETDEAEVDENVPLHRRPKTFVSSLKTDQYIKAIANMKAKGALPGKEWTDQETLLLLEGLELYRDDWNKVADHVSTRSQYECILKFLQLPIKDSFLDDAKDFDSVLSIENGPLPFSQAGNPVMSTVAFLASMVDPRIAQAAAKAALEQYSKVKEEIPPVIEEAHKRNVAQHYADTGKLNASIGLDAIIPGSENKEDEVMETGEEDAVTELAKEAKKLSDETISTAAAAALGAAAAKSKQLAVVEERKMKSLVGQIVELQIKKLDCKMKCFEELENIIDKERELLELQQTQLLVERQQFHADQMRYLDSRARMDAQQQLVTEGKIPAQLPPGFEVSGPPPPTQTIIAPAPTTISKSETETSIKSETSNENISSQVQRQIQQPVQQQPPMQNQMQQQQMTQQQQLPPPPQQQQQPQQQIPQVQSHQPPPVGPPQQMMQQPASYPPPQQPGQYPPMQQQYPPQHASQPPYQHGYPPQQPYGGQPQAHYQQPQQPGYYSTQPAPPRQPYPQQYPPMQSYPGQPQQGYPPQQNVRQQYAPPPPQGQMWGAGPPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGJ1</accession>
    <name>A0A0N5BGJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000509450.1">
        <property type="protein sequence ID" value="SPAL_0000509450.1"/>
        <property type="gene ID" value="SPAL_0000509450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000509450.1"/>
        </source>
    </evidence>
    <sequence length="52" mass="6300" checksum="701D7EF52D5305C8" modified="2015-12-09" version="1">MQDNHVVNLVGIYFLKINILLERLHHLMFSRKLTPIILLFVDRFLFLLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHL4</accession>
    <name>A0A0N5BHL4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHL4"/>
    <dbReference type="STRING" id="174720.A0A0N5BHL4"/>
    <dbReference type="WBParaSite" id="SPAL_0000545200.1">
        <property type="protein sequence ID" value="SPAL_0000545200.1"/>
        <property type="gene ID" value="SPAL_0000545200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF12">
        <property type="entry name" value="RHOMBOID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWH43-like N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000545200.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10198" checksum="3320A62A3E0F94C8" modified="2015-12-09" version="1">MIVAFYLYFKKCTKYAYEIFAICEYLEVVVNILFHSTAYWDIKNKILLCTRYVEKYVDEKSKALSFDKKICLKVDEGLCKINISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHV5</accession>
    <name>A0A0N5BHV5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="STRING" id="174720.A0A0N5BHV5"/>
    <dbReference type="WBParaSite" id="SPAL_0000554000.1">
        <property type="protein sequence ID" value="SPAL_0000554000.1"/>
        <property type="gene ID" value="SPAL_0000554000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase ubr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="13">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1685"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1685"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1696"/>
            <end position="1707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000554000.1"/>
        </source>
    </evidence>
    <sequence length="2103" mass="239353" checksum="D98A186C3954FB46" modified="2015-12-09" version="1">MIDRILRAGKDEDWILATKLLYEHWTENCPKVFIEKSDTPWNNTLDEAKVYDELIRPVASLYIGKEIKSSEYENDEDRGCSLEQLANEYGCNVENNSKGQICGKGFGNGELTYHCKDCEVDGTCVLCKDCFEKSEHKNHNHKVSVSIGGGYCDCGDPEAWKNNFACGDHQPIEAESGTDSQSTLPQIPPQIESRIRQLTLSVILYSISVLYSDGDEKLSNLLNLSGKSKFQNNFQAVLYNDETHTYENVIKALVNAINVNEDTACKIATIIDKQGRATVKIGTKSDCEKVKQVIIKRTNRENSSNKGKKDGPLEVKVLSSITVAVQEFAFFLLKWLNKQMTVFTPLQNIVADICLNRYCNPDNTIDNLCSGPTHPKDSAEGYDDDDDIQSMELGTEKNESLRIIDTITDDVQNFFDILTKPHDDSPKTPAEMARQRCNRRKRDKGDIIIALMVKANIKWWKSVRLTTQSFIMTALVRRLDYKIQFSKILIAHYKKLLKDYCMDDHHQLVSVLSLTVQYFTVPTVAKAIIADDNAFGVCMQTIIKLMNAYLKKSKYNQALEVYDFQDGSYGKHPYYVKRLSTILVDVQYLLQSVPSPEEWTPELRNGFLNGVDSLFQFFGYIQDMNQTRKHYGEHQVWEMEWETAFYLQLYLQNIAPLVIDWALSDFEVYKEVFKRVYDRIKDLINKHPDMTGPKKEITINGVTASCIDFDINNKPVSIHQPLWRIFAGLFTANNNTFLNNITTNASGIRLEWEPSPYRMHLDLAIMAEPPLRCIIFLNQVTLGMWRKNGFGVVNQCHNYNSSNCRGEMFDRDIILLQATAALTDPDQFIIRMIHRYGLHNWADLDFDYDILKANHEASLAHESASSNDDTITRIPNNRTRLLRTTIMGTDFRMETVFGQVNQTPPNQSPLLEDSSKHLTGLAEEMLNLVIYLICERYVKGVGKVTLQDILEREIIHMLSVNSLPFSKIEKITNWGDFTEELLHNALKNVATYSHPEKSVPGIFTLKDEIKQYFSPYFYHYTKSEASKAEQTQKDSRKNLDLELRCCPPHILPEFDDFYKDVPNLLKCTVFVSLQKAILERYASKSRFSSEGLVNRICYTICLALNEQKKHEKPDTYDYISVGENYDILKLLKGALASSPLSNCSDMITYTIQKYEEVCAWYFGKEIVKETVSENKDSQEELERANRRAEKAKKLREQAMKKMMNKASHFMKHATLNENSKGGEGPGTSQRSKLLSVMDDDEETGEIINDKGFPVCLGSHKSEILPIEKKQALCILCQDTERLKFGKTGFVCCAYAYKSFLFTQKDCPGSKNTNNLDVFVDASIPESLAIMTCGHTIHYQCFKSFKESYKSRNNQRMTNSQSSKIIDIEGGEYLCPLCKRISNCAIPYLPHQDFSGITKVSLHTLPTKNEDFSTWLLKYRRAVEGRLNGIETSIVKQRPHKGHSRKRSHSERSLLELAKQGDEPFIDSNLSSTPTAKCASEASLPINTEVGGGMSGDLSSSDGFRSPTNIGSMDSSFFDTVSPKNLLSNIKHMKKAYFYKNKKETIPKIMRDTEMMYVFINTMAEFRKDSPTSKDQAQKYLKICNIWHTCVFILRQVAAVLEEENKPLFGALNFRQKESLKCLTRMATSSSNFISSINSRSLAAILLQPLLYPLNSNDSGKNLKEDKISPFPVLSKFHVSLMQRANSVSSDDSNSQRSREVKSPDHGNKLFSNITTPFFKDMGQETLSAKAANRIKKQDSLLNIDCLTLAFDLLMVIGHTSINGEVFLHDKFKEDTCNLVVDGSQDELNVIQLVLYAHIFQILATFEEIDNSGESDMPLQDEIYVKIMDIVNAIGKDDKQFIRNIEQNYNKVKERIIKGILGYLRPLAIFYRILTLVPPPEVLKDPGFDQLSPLLRYMGLPYSLEELFSVEGILPLFEMWGKQLPNKSSGSGTHYYVKQPISINKLIDLPEDFTDIIVEASKFKCPSSSKADNISSNPALCLVCGKILCAQSMCCQSKVNKNEEIGAGNLHMQTCTGQNGLFLRMRECIILAVTTKNRGASYNGPYVDKYGEQDGGNKRGNRLFFSDHLYSKFRKAWLHQDVVEMIINENEVNHRLAVYEWRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJH0</accession>
    <name>A0A0N5BJH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000609600.1">
        <property type="protein sequence ID" value="SPAL_0000609600.1"/>
        <property type="gene ID" value="SPAL_0000609600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000609600.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55595" checksum="6304EF06DF62067A" modified="2015-12-09" version="1">FEEQLKELAELVRKSQPNASEEAIVEAQCNRIEREVEDWDTLWNKATSQEWRSPSELISALVSTNDHFKRKKERGLQRKEVSGSHNRHENYFGKQYNEKNKVRNVPSCFECGEQGHKRYECSKKGKEEPCIQSKLCEVKKVEEEPKLNYVEPIDLDERMKLILMNRIKVDEIGEDVTLPVLIKSEKELNNNYISILALIDGGANKTSVTYNLAEAMGWKVDDLDEVKVGLAGNIEGTFKKGHQVKLMPIQGGFDVDLRVCVETTRRKDERYGITLGTDFLDMKGVAVHHGQNKMTIGGRLYHGASYNDWNRLKTMCERKKSRESMITTRPTLSCDDVKPYVVQVPKFQFNQRKIPKPAPFDKYSVKHWGEISEKIKEIPEDGDGISVKNDYALKRQSKKGKTRRVYYKRLETFQEIPTFFMKFRTRQKVKMKETVINQIKFETSQIYAITEVKSPYVNLKVGKNKDKPLKRHAKEIVGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLQ7</accession>
    <name>A0A0N5BLQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000685300.2">
        <property type="protein sequence ID" value="SPAL_0000685300.2"/>
        <property type="gene ID" value="SPAL_0000685300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894698" evidence="1">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000685300.2"/>
        </source>
    </evidence>
    <sequence length="328" mass="38777" checksum="4B84AA8375AADD46" modified="2015-12-09" version="1">MRISIIVYVSITFVINLVKTQELAVTYMTMHMGKRKFYSYREKTYATIRQMLMKVIKDHKHIDLRNLLMTKISSISNGVIYKKEEQKYRSLFTGNYVTHISPFVIIEYFIKNKLKYICNGNTFYSYYDAFNYAMMAKRNHSKFPTQRPSSPLLPPLKNINWAREKVYCKNFWLILWKFCDYYCYSRNNFEVMKQKFLLEVNYYREKYGAGKLVESKKLSAAALNYLKEVISLSGRMDITKFENVGKGSLARAPLIMNHWFGEHKNYNWKTRFGSTETRHFTAMVWKSASKIGIGVVRSGNDIYVKVMYNMNVNMPNQFEENVLKKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLV0</accession>
    <name>A0A0N5BLV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC1 domain family member 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLV0"/>
    <dbReference type="STRING" id="174720.A0A0N5BLV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000689600.1">
        <property type="protein sequence ID" value="SPAL_0000689600.1"/>
        <property type="gene ID" value="SPAL_0000689600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000689600.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="41215" checksum="53F9A254F6F29DDF" modified="2015-12-09" version="1">MSLESTSKSILNQNYITGISDRVEPVRVKEFLDKYVINTEVDVDLQKVYNITLKHNIPSQCRIYVWKICLDITSQHYVHRDEIKNIRRSEAFAALKTTKGFLCNEPLFNTLGDTIEDKSFVTDIDAVNRVEKFVFYMVFYCRPASKRTKNNVEYQLSLKALRCISIVINNMCKKFTSYLAEYWIDAYWLTKRMDQLLEHHFPMEIDSEPLKNFYLSVRKKITELQKECFADNLQAKTIVDKGLVLINDTTLVLWFRSGGANWLRPSSLYKLWDKIIVLQKIDVLLEQVFLEILRAIFRTCVNSYENNPNVSPLNMNLWITEEKEQKIILRVVDKHYQSNSISIINERTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM13</accession>
    <name>A0A0N5BM13_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UNC93-like protein MFSD11 (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM13"/>
    <dbReference type="WBParaSite" id="SPAL_0000695900.1">
        <property type="protein sequence ID" value="SPAL_0000695900.1"/>
        <property type="gene ID" value="SPAL_0000695900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF18">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000695900.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51732" checksum="7C87E678E6D8499A" modified="2015-12-09" version="1">MARELLLVHLLGVGFLFLYLGFDIKSMIEENMLHSVSHLDPNRMNPYAGYYGLALNYAASAITALITSYIVDTIGAKWSMVLSGFIFTIHMAFFMFLNSHVYYIVSALMGLGNSLSWTGHGVYLREITTKNNYLRNSAICWAVNLISLPLGGIALLVLEEFLEGELMDYMPISTIRIVMSLFLATSFISFILFSTLPNFSGSINAFSKEKLVNSLKKNLTMIKDRRLQLLIPCFFFIGYESGYWVAIYPTCLTFLKTLNLGSTLRLTAFYTIACGIGQIIMSLIISWISKKYTVNGYKYSITLAGILHFMTFVLIFCCIPPESKYMHTSKESFLPANAFTVLLISFLLGAGDGAWNSIRTGACTSQFKDETSQAVSLSRLFQSIGCSLSFIFGPSLNLYIEMTGLTIVLVVTLISLFFLNHNYLVHTLMEENDKIKNDSERKKEDIYHIESENTFKNIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMW3</accession>
    <name>A0A0N5BMW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SLBB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMW3"/>
    <dbReference type="WBParaSite" id="SPAL_0000724600.1">
        <property type="protein sequence ID" value="SPAL_0000724600.1"/>
        <property type="gene ID" value="SPAL_0000724600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000724600.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10205" checksum="7A0A16620D62D3A9" modified="2015-12-09" version="1">MFLKIFTTFIIILIYKISISYTYRTIIVPQGLYISVFGNVTWNDEDINSVKAALNNTKHPEKSDVRDVTKNKEFFLSLYAGGSDYDIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNZ8</accession>
    <name>A0A0N5BNZ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNZ8"/>
    <dbReference type="WBParaSite" id="SPAL_0000762800.1">
        <property type="protein sequence ID" value="SPAL_0000762800.1"/>
        <property type="gene ID" value="SPAL_0000762800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000762800.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18304" checksum="9722928F7ECD6EB2" modified="2015-12-09" version="1">MGRKEITFEFERFPDYPGDEEELKNLLRGIHAVVCRLDPGRGIHFNSFSELCTFFKPLWETDLGMTLRSLLVDAYSHGNIFYKDCSHNTNNWISLALKLNKEQKNVLNMVEKGQPISFVQSPPGTGKTTTAISIAFNNPKYTYLIISESNRGTDAVNPREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPA4</accession>
    <name>A0A0N5BPA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Splicing factor U2AF 35 kDa subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPA4"/>
    <dbReference type="STRING" id="174720.A0A0N5BPA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000773000.1">
        <property type="protein sequence ID" value="SPAL_0000773000.1"/>
        <property type="gene ID" value="SPAL_0000773000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000773000.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27757" checksum="E1391663C02C1B88" modified="2015-12-09" version="1">MSSNHAGAEYLASIYGTEKDKVNCSFYFKIGACRHGDKCSRIHNMPSFSQTVLLRNLYHDPNLDMRKADVYAKVGQMTPEEQREFDEFYAEIFEECEEKYGKIEEMNVCDNIGEHMIGNVYIKFEREEDAEKCVNALKDRWFNGEPIYPELSPVTDFREGCCRQYEQGGCTKGAFCNFMHLKPISRDLHRRLYGRRSSPLRNRGRYGSDRDRSSRRRDRDRERDRDRDHYRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPL7</accession>
    <name>A0A0N5BPL7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BPL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000784200.1">
        <property type="protein sequence ID" value="SPAL_0000784200.1"/>
        <property type="gene ID" value="SPAL_0000784200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000011">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000784200.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17598" checksum="BE7FCD6BE449CD3C" modified="2015-12-09" version="1">MRIHTDEDFMKIAVKEAETGVNANDGGPFGAVVVKNGEVVATGHNMVLVNNDPTCHAEVTAIRNACKELKNFSLKGCVLYTSCYPCPMCMGAILWSGIEKCYYAANSIEAASVGFNDEDFHLFLQGKKSNVKTTLSELKVDEYMKPFNTWNQKTDKIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPP4</accession>
    <name>A0A0N5BPP4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPP4"/>
    <dbReference type="WBParaSite" id="SPAL_0000786900.1">
        <property type="protein sequence ID" value="SPAL_0000786900.1"/>
        <property type="gene ID" value="SPAL_0000786900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF819">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="41"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="287"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000786900.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45262" checksum="E165CB9C65E9C0B7" modified="2015-12-09" version="1">MYNTTIPKMDGLLAMSSDKVPTHYSIVESVSKTHLHRHRRQVIAGAMYDWRSNEIPFQIWGGDFNFQNLIRRGIKMWETETCLRFKENMQAQDAIRYVLERGDSCFTEFIGRNGGFQDIIIGSECAEEYVVAHETGHALGFWHTHQRPDRERYISINWRNVLEEATASFMPFRSMLQAFGIKQVSSRRVPYDYGSLMHYHAVAHAVKVSDFTIVPKELKYVTTMGTEKMAFLDAKVINDIYCTNKCVGFRPLNCQAGGYPDPNNCNVCRCPEGLGGVECTQLQPSSCGAEIRASNQWQTLRSPQGKNVHCYWRISVPEGMRVRFRLSDGEFPCSYGCQSYVEIKHKLDVRLTGFRSCCYRPKEDTVSEGNQIFVIYHPNGRTARFTLRYIAQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ12</accession>
    <name>A0A0N5BQ12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ12"/>
    <dbReference type="WBParaSite" id="SPAL_0000798700.1">
        <property type="protein sequence ID" value="SPAL_0000798700.1"/>
        <property type="gene ID" value="SPAL_0000798700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000798700.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19772" checksum="6DEEA3909545311C" modified="2015-12-09" version="1">MKNNMIIFSSIILFLYFDLTFEWVKFDYKTRNRVYRWGKNSTIELCQNITAQIIFGFRNQTYTVTMEDKEILKAFKGIGLYTPVNRFYYRETYSRVTFKRVHDSIFYPEISKFSYVGDCACGDSLCTYFQAICIYTYWFGRLIYGNHSMCTINPVIAWKSMNLNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQE5</accession>
    <name>A0A0N5BQE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000811000.1">
        <property type="protein sequence ID" value="SPAL_0000811000.1"/>
        <property type="gene ID" value="SPAL_0000811000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000811000.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="37373" checksum="74FDB717B3726096" modified="2015-12-09" version="1">MDLISLPDELKVQILKELQWSNLNNLKLVCRDLYLTVVRNIEELDRPKVEYLKIYYAENEILRVDYKSKHSEINLRDRVLHHIDFNDDHEYDIFLKDKDFTELKRLTFKNVTSGERLHVKEACLIFGNNILFPCYSISLSNRTSKILKISVAILRSCELRIPYNGSLLRKESLRKFGLFEKDGPRLFIRKVTMDIFTRNPMLKYEKISVDTNRLIFSQIMKHLYDLGFFSLENICKREKFLIVFDGIGDFTRSEQEFYREFSEKIKFDNNLRIKDSDESYSIRSSMNCSQCNGKHRHIIHHKKSTNEICIGLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR85</accession>
    <name>A0A0N5BR85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR85"/>
    <dbReference type="WBParaSite" id="SPAL_0000838800.1">
        <property type="protein sequence ID" value="SPAL_0000838800.1"/>
        <property type="gene ID" value="SPAL_0000838800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000838800.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21211" checksum="415B4AABFA80BFF9" modified="2015-12-09" version="1">MNSNCFNLSSISSVVDSDVAPKFCQKTTIYILKMLNKLCNTRKLVPSFLLLDEVCSSLKFGENIDEKELINILQNIVWITKIKIEENDVSALKLIASRLLKINKHSVRESFNDEKYNIFSIKNKNFIGESDGDYITTKTPASTSTPIKNSISLSSNKPSSTISSNPIDSNLQCSTTMLPLTNSNNFDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRL2</accession>
    <name>A0A0N5BRL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BRL2"/>
    <dbReference type="WBParaSite" id="SPAL_0000850900.1">
        <property type="protein sequence ID" value="SPAL_0000850900.1"/>
        <property type="gene ID" value="SPAL_0000850900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000850900.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="66895" checksum="5D5DCF4FF59232C3" modified="2015-12-09" version="1">MVHERNRCSNDSMKRTPIVLLFFLYVFIFSFLSENVTSIPHRSHEPWSMILCKFKDTKNITPKTRDWYEEWFAGDNPDSIKNYFKWLSNGNYDISGSNVVGWYDLPWTINEVLYISQHDTELQNSDEKSFAFYDKVKQLCIEEAERRGNILFSQKITVINVGSTALYGKKYGVLLTPSLMFSSVLTHEMVHSFFIGHSYSDRNVKIFPFSQPGEYDDRYDLMSTANAYMHKSRFGMSGPGLNGPHLDYLGWLPMDRMLYFGKDGRQNYTIRLSSLSISFEKTHGWLYVMIPYDRDDSNLVYTVELKTPSYFDKGIGQPSVLIHRIQKTGNFYYSVLMSQGIDFYELTEGTEWVTFIGSDSSGKFQWIKISVKKIYNFDADVSITSTFDPRVCKIDEEIAFINIRENEPNNDSSNHVNSLSYCKPKRKNLRQSIDELVKKHQRRKNFFSHLQTFGLNACKEGKVWRSIDDYDYVCVDTRRKDDVRFTQEIANNNNNFDYNDITNNESFINSKNDKRVKKSTQPCRQPLVERKAFLNDNFCVSALEHKRIAQENKNAHRYLKNYAFFNGADTVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRQ9</accession>
    <name>A0A0N5BRQ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000855400.1">
        <property type="protein sequence ID" value="SPAL_0000855400.1"/>
        <property type="gene ID" value="SPAL_0000855400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="294"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000855400.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="73309" checksum="69372A78F1F13A27" modified="2015-12-09" version="1">MDKRKVLTYFLIGFSIVILLVGTALIIVGSIALNDSKSCSKNSDNSLSSTTPSTPQNSTPSSGAVTNYFFRLNMKLQNKYKMNTKYDAQSQGLEVLSKVRSILSSTSESKILSILSIDNDCSSLFINSYKVIISLVYLNNAPLMNDISDLFTSNNVNVLEKKNLTDGYVPLTSEDETCKSFCDLYCYNTTTALPIITTTNDVQFTTTTNDDSITTTTSNKLPFSTTTNNSPFTTTTNGSPFITTTANGSPITTTTNGSPITTTTNGSPITTTTNVSPSVTTTNNYNPIDIPSCSTILAVDSSSYLIPSLYKAELQTIKNFSSVITHFEDTLVISYDNATNIVRSFGSMTNGNDFENAIGSINQKSGLRLSNLLTTLLVILKNRVNETINTVVLITENIPDEISHSKLLVEKLKSMGSISFIIVGTGIKEDDLKPLNPTNIYVYDFANCNETELNNKFKDFTTCPTTPYFYDDSDALPEYPCNGSIVFSIDSSSVLEKDKFEAEIDGLMSDQVITDDWNDFQRISLVKYYNSTDIVFNFNFAQTREKFFEMVKIVQQSDGNINFANLLAALESGLFFYPPNEMQNHFIFLSNDITVKDIQISIPYAKAIQNKGNLNFIVLGENILPGLNFLTNDDRILYWDYTNNNSKEVLKNFIKNKMTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSB9</accession>
    <name>A0A0N5BSB9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uridine/cytidine kinase</fullName>
            <ecNumber evidence="4">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSB9"/>
    <dbReference type="STRING" id="174720.A0A0N5BSB9"/>
    <dbReference type="WBParaSite" id="SPAL_0000876300.1">
        <property type="protein sequence ID" value="SPAL_0000876300.1"/>
        <property type="gene ID" value="SPAL_0000876300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="10">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="396"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000876300.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57029" checksum="636AC82F1BBBBA1B" modified="2015-12-09" version="1">MGEKVPNITVNDCDNYCNGETDDLLQKSREISSVIRQRQTSTSKFDDIMECQLDEAMSRKIYTKGRPPWFDETGKKQSEAFVIGICGGSSSGKTTVATSIVSDMGLPWVNIVSMDSFYKVLTPEQKKLAGDDDYNFDVPDALEMDLVVDTLHKLKQGNSAIIPQYCFTTHSRIETASKIHYGSDVIIFEGILAFCDKRLRDMMNVKVFVDADADVRLARRLKRDTEFRGRTIESVLTQYMKFVKPAYETYCEEFKSYADIVVNNNSNDHAACQVATNFIVKKCESVLSDKGYRSSKMYKAIPYNIYLPENVLSSGLPPNLITSEKPYNVNGVYNIIKKSMVSRDEFVEISNEIMNEIGMSCLEKFKSIDRPNTVISYTVAHEIVESSPSFYKNNIQKGNMLVKIQQQTNIPELYTCSLPRNIDKSKCFLFDPIISSGSVLMAIRVLLDHQVNEKDIYICGILMSDRAAKSIAYAYPNINMIVRNVEFKSEIDALKPGIYQYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BST1</accession>
    <name>A0A0N5BST1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein PXR1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BST1"/>
    <dbReference type="STRING" id="174720.A0A0N5BST1"/>
    <dbReference type="WBParaSite" id="SPAL_0000892300.1">
        <property type="protein sequence ID" value="SPAL_0000892300.1"/>
        <property type="gene ID" value="SPAL_0000892300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000892300.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45971" checksum="E4F7623D7A067F58" modified="2015-12-09" version="1">MERGGGIEDLIMMCASDAPESNFNKKNSKRKPKKKGGNKKSQNGQKEKENGDYDDIEINDKEFDEVGDPEEKIEKKTRGRKKKDDEEKVKDDDKEDDKDKDKGVNEMKERRIRKKNKREKKENDKEVKKDSGSEEIFKSKKDDEEKVKDDDKEDDKDKDKGVTEIKERRLRKKNKKEKKENDKEVKKDSGSEEIFKSKKDNEEKSVDKVRKTKKTKNNDEENDQEKIEKNDCTENEKLKKKDEKEKSIKTKRRRAADTECKKEETTRKKKVDEDVEVSRKKDVEGTDKDKQKKKLDEEADKNKKIVAEEKDQKNGNNQEVIEKKRAKKKVATGGKTKADDSTDKRKVKSVNVKEEKKKAKASDTDNKKKTKVPEEVDKKKSKQLPNQKSVVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSX0</accession>
    <name>A0A0N5BSX0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSX0"/>
    <dbReference type="STRING" id="174720.A0A0N5BSX0"/>
    <dbReference type="WBParaSite" id="SPAL_0000896100.1">
        <property type="protein sequence ID" value="SPAL_0000896100.1"/>
        <property type="gene ID" value="SPAL_0000896100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SULU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000896100.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="49121" checksum="890AEACDDB150AC2" modified="2015-12-09" version="1">MQQKKFINQKSLYQRVRDFFYHAYTFGTVQYNFENIKFIGKYYLDKKKIYTLKSCDIYARNSSDPSKEIKYKGIIRQINIEGLNMTIFNECEDFNRHLEDIRKIRHPNIDGGPIVFYNEYFVTLNIYPEQRLLFIYKECNGVSLSDILETDKNFFKKNTNSTIKLLKHLGNGLLYLHKNNMVHGEIHSDNIILTKDGVYKLINSCFFHILSHIRPQNKIREMKCLYYNSPDALVSEKFITKEEDVWAFGVIIYNLYYGFNNYYFKDLLPMYQIEPDACLIHIFQNYGPYFNRHEKMPEILYNICAGGIWKISAVRANMKTLMRLINSIEYCNNSKNFICHEKDLYNEIVSRINDMPSNVLYYYRLLAWKAFVIKTKSLKGSDQQSTTYYSNDNKKDNDKKPNNDKKPNENAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT24</accession>
    <name>A0A0N5BT24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT24"/>
    <dbReference type="WBParaSite" id="SPAL_0000901700.1">
        <property type="protein sequence ID" value="SPAL_0000901700.1"/>
        <property type="gene ID" value="SPAL_0000901700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000901700.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22405" checksum="514B86A17B664851" modified="2015-12-09" version="1">MENYNNPQERAGESIENPNIIDDDDERNPIREEGNIIEMEENENSDTDDEGENGYIPDFATRGEYDAENKICFYHMGYYPDRFTRRIEEDEYGVTGIYVLIKREVENPNHYTALLQENPIAKDLKLRLEEEPNQRSELAVRQIVQERQWENVEVVADYAWRHCFNIFLITGKLTIKFEDLSSFWRFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT98</accession>
    <name>A0A0N5BT98_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT98"/>
    <dbReference type="WBParaSite" id="SPAL_0000908500.1">
        <property type="protein sequence ID" value="SPAL_0000908500.1"/>
        <property type="gene ID" value="SPAL_0000908500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF32">
        <property type="entry name" value="GST_C_6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000908500.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33571" checksum="B6768C030188FBF1" modified="2015-12-09" version="1">MLSSTVRNSKNLVNFGLKNSLQTTLFYSTEVAENKRKATLSKTSREKDVVYVYQLKRIASLPNFSPFCLKVETFLRAYSIPYKSIESWAAKGPRRMVPYIELNGKKISDSQIILDYLKDHYDIKDNLTPEEYSICRAVERMVEGSTFYAMQYHKVIDNAVSMFNPPVFGYKLPPSEIKLITRKIVRRFKKRTEGQGYWKFTHSEIQTVLENDLRALEVLLGDKKFFCGEKPTTADFTVFAHLAFNYYTPFDMPIQEYMEKSCPKLKEFLKRMRVLYWNDLKPLRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTY9</accession>
    <name>A0A0N5BTY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BTY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000931400.1">
        <property type="protein sequence ID" value="SPAL_0000931400.1"/>
        <property type="gene ID" value="SPAL_0000931400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="99"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="221"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000931400.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38786" checksum="65AF457E9217BF4C" modified="2015-12-09" version="1">METSTNSGKTLGDNNQKMVTSDGKTEKEKLESLNIEKIRSKIKPSSFGLKPKNSSVCIDSDKWYLTLQESSKKLLANPPSIVDGIPINIEQELRYLGCELIQSLTILLKMPQTAAATGQILYQRFYYQKSFAKYYFEHAVMACVLLASKIEENPRRCREVINTFDRMKKRHALKNTPEENNDIPPIDLDQHYVHLKNSVIKTERQILKTLGFVVYVNHPHKWIYVFAHALRQIDNSELIGKAWSYMNDGLRTDIFLRYQPNTIACACLFLASRTISSPISLPKKPRPWYEIFDVQEKDVIHISKILLLMYNRYQSVDWIKLRKYVSKICFPDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUI5</accession>
    <name>A0A0N5BUI5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal_L7Ae domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUI5"/>
    <dbReference type="STRING" id="174720.A0A0N5BUI5"/>
    <dbReference type="WBParaSite" id="SPAL_0000950500.1">
        <property type="protein sequence ID" value="SPAL_0000950500.1"/>
        <property type="gene ID" value="SPAL_0000950500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="1">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000950500.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16879" checksum="AA4CCDFF44AFB78A" modified="2015-12-09" version="1">MCDLDQVCYIFLKRLKFLDNRQYCKNPSKARAHPKFSIGIKEVHRKILYTNMKVIIIANDVNEEEVHEKIHLKIDLEEICKNKGILLIQCLSKKVLAKILKKSKTVSCVSILSIEGAEEEYENLLRVSKIYLPILKQIHQNSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV06</accession>
    <name>A0A0N5BV06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1189 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV06"/>
    <dbReference type="WBParaSite" id="SPAL_0000967400.1">
        <property type="protein sequence ID" value="SPAL_0000967400.1"/>
        <property type="gene ID" value="SPAL_0000967400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000967400.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12462" checksum="4AD1348A4DFFBF90" modified="2015-12-09" version="1">MLHVTSLITILLIIYFINIQTIFCTFVNPTIEVLAKIYQNDDISQEYFFITMTLVAITITLLLPRIILISLLLVDILMFVGATIGTLIMIIFGIISCQYMAIKKKIFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVJ0</accession>
    <name>A0A0N5BVJ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ResIII domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVJ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BVJ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000984700.1">
        <property type="protein sequence ID" value="SPAL_0000984700.1"/>
        <property type="gene ID" value="SPAL_0000984700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000984700.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17579" checksum="2F87B5C4FAC633DA" modified="2015-12-09" version="1">MRHLSFSITDNAEDELVNLWRRGMEELFLPQLVKNYIPARKFHNTIFNDILYREEQLDEAQQILARSIGSNKKFITCLAPVGCSKTQSICSVLLTCIEDKNKGFLFVGLTNKSCEAIMERFVSWAPDPSKILIIKSRAAMVRHPDGFYKSKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWR2</accession>
    <name>A0A0N5BWR2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWR2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWR2"/>
    <dbReference type="WBParaSite" id="SPAL_0001025200.1">
        <property type="protein sequence ID" value="SPAL_0001025200.1"/>
        <property type="gene ID" value="SPAL_0001025200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001025200.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34525" checksum="2AB622673C7CF5F7" modified="2015-12-09" version="1">MVKESLIFNPKQFFENLLEGNKENMSTGLAVIKTLSEALKKTTASTVTGLLEDLNNARDELCKTDYSTASIRSASELFIRSISLVSSESLQSDFQELIKIFISRAYKFTERVDNSRSMIAKYAAPYIRNDMKILTHSYSKVVFEALVSGAKEGKSFHVYVTESQPDSSGRIMYEKLRKHNLPCTLILDSAVGYLMESIDIVFVGAEGVMETGGIINKIGTLGIAICAKAYKKPVCIMAEGIKFVKEYPLNQADIPNEFKYNTSTLLNKDLSKEHPLVDYTPPQYIYLLFTDLGILTPANVGEELIKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWX6</accession>
    <name>A0A0N5BWX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutL_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWX6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWX6"/>
    <dbReference type="WBParaSite" id="SPAL_0001031500.1">
        <property type="protein sequence ID" value="SPAL_0001031500.1"/>
        <property type="gene ID" value="SPAL_0001031500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001031500.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20092" checksum="2E7E4D8A6041F2C3" modified="2015-12-09" version="1">MDTSKITELITMPIEVLLENNISVVGNVFSIDPETLNFIIATFKNETTIESIEFIPKMTIIDYKIINKDDILKYPSACFRNKEFVSELFDKLLPECTNTKNLCNENVENRQKALLEFLKTKKIQQVTVEQETQAIVIAKNFRVNSPYGVDDIVCSMPHILKRMKIVLEPFFESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY19</accession>
    <name>A0A0N5BY19_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY19"/>
    <dbReference type="STRING" id="174720.A0A0N5BY19"/>
    <dbReference type="WBParaSite" id="SPAL_0001068000.1">
        <property type="protein sequence ID" value="SPAL_0001068000.1"/>
        <property type="gene ID" value="SPAL_0001068000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001068000.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34273" checksum="B69687877510214D" modified="2015-12-09" version="1">MVREDRNAWKAKYFARIVKLFDEYPKLLVVGVDNVGSKQMQEIRIAMRGHAEILMGKNTMIRKAMRPVIQQKPELERLLPLIVGNVGFVFTHEDLGETRKKLLENKRGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKISRGTIEILNEVHLIKTGDKVGASEAALLNMLNITPFSYGLEVKHVFDNGTIYSPAVLDMTDEDLREKFMEGVTRIAALSLGLGYPTRASAPHSIANGFKNLLSIAAVTDVTFKQAETLKEYLADPSKFAAAAPAASSAPAAAASAPAKKEEVKEESEDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYH5</accession>
    <name>A0A0N5BYH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase_M13_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYH5"/>
    <dbReference type="WBParaSite" id="SPAL_0001083000.1">
        <property type="protein sequence ID" value="SPAL_0001083000.1"/>
        <property type="gene ID" value="SPAL_0001083000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001083000.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13837" checksum="76AC12C24CBC2B59" modified="2015-12-09" version="1">MGNVWGRVWGGTKKFFFELWNRHPASRSLYEFLDRDVDPCDNFYQFSCGKWIRTMELDFEDSDSVNTRVSMTNFNKFREEAMEGKYNDESSAIHNIYKLYGKCKDLSEDEIGKCQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ37</accession>
    <name>A0A0N5BZ37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ37"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ37"/>
    <dbReference type="WBParaSite" id="SPAL_0001103300.1">
        <property type="protein sequence ID" value="SPAL_0001103300.1"/>
        <property type="gene ID" value="SPAL_0001103300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001103300.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="71420" checksum="BB9863F12F19AEA2" modified="2015-12-09" version="1">MSGKSELRRRAVGVQKKNKKNLYRYEEFEQVLDRIGSFGTFQIYVCFMIFLWQIVWAGNYTFIEFVGAIEPDWNCTLKNNQGYMTFAAPVKDKDCDLLKEKCESFTAIKDSKPFHSIVGAFKMICDDKDRPELIQIIQSGAMLIGAIIGGHIGDHIGRNTFFFLGQLITIISSTMTTAAQHWWSYSITQGITGFIYGAIEVMVMTTMMELTSNKYRLIPNASFQWPLAYLSVSLISYLTKDWQLYFIFLNAVGSLISVGFIMFLESPRWLVATRRFEEASEVLNDIAHCRWNDANVHFTENDLVNLPSEPREKYRFYNFFHLFSKFKLAQQTILQMLSMFTYSIISINYNYSITTWETDVIPFVAINGGIRFIIPILIILFDFKIPSLGRKVQFVASLVLEGLCFGTVIILMLCGYDHTFKWINVIVTIATLINDSAFWMNIVQISTQRYPTVIRCTAFGFIQAFKHAGFIVGIYIMKPLMEGSNPIYAFIIPEVLIIITIIGGVILQPEVKGKSLKDTMDEVNKGRQVTRLPTGLLQLVSQFRVDQMAHNLELEEAFVNKLSRAKNKPDNIMSNPKNIISEEELTKRNTHVNDGYEYNESSDEETYKNERLSISSHSTTNTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ39</accession>
    <name>A0A0N5BZ39_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S ribosomal protein L13a</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001103500.1">
        <property type="protein sequence ID" value="SPAL_0001103500.1"/>
        <property type="gene ID" value="SPAL_0001103500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001103500.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9145" checksum="EAD12B0D9917A5B2" modified="2015-12-09" version="1">XQNSNYFWKKHHRAQKKIVPEGQKDSYREDKFTLRGHIYYKTPEILPFLCGVLAPAKLVEEAANKKKRSFQLMKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ52</accession>
    <name>A0A0N5BZ52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ52"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ52"/>
    <dbReference type="WBParaSite" id="SPAL_0001104700.1">
        <property type="protein sequence ID" value="SPAL_0001104700.1"/>
        <property type="gene ID" value="SPAL_0001104700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001104700.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28495" checksum="0AA506F76A8E9BB4" modified="2015-12-09" version="1">MNPNKEISIPIFNLNNDNKNKNSVLTDLEQNYSHFNGMMSQIKAAPYYDEDKFLLVVKRIMDLEEELKISGINVPKDEALFEKIVLAMLKDYPNTDLQIVATSSRRITTTKMSYDESTPGMDNKSDDEVMKTQRKLLDEIYEKDYEKEVDGMTSQDKIQQSEKVDEGFTEDNGDVISKRMTHTIVTTQTTSLPEHELYESGDKKITYDEHQSGDKFRLKVNNNIYDGILQKSNSVGEFMDSSINKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ86</accession>
    <name>A0A0N5BZ86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ86"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ86"/>
    <dbReference type="WBParaSite" id="SPAL_0001108000.1">
        <property type="protein sequence ID" value="SPAL_0001108000.1"/>
        <property type="gene ID" value="SPAL_0001108000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895086" evidence="2">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001108000.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17166" checksum="4B0C871262F8E3BA" modified="2015-12-09" version="1">MVSFSYKILFAILLVVLLSVELNSKPAQNGKQPAKSNGKEEEKNPSPHRQGGNHPLAKGLGGRHPIPPPTGETRPPCGDDSSSKSSVSHKRRGPGHRHGRRHRRRHGKGHRKHHNCTTTVEPKSTTIARTTTVETTTTEPTTTTTTETTTTTTPPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C034</accession>
    <name>A0A0N5C034_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C034"/>
    <dbReference type="STRING" id="174720.A0A0N5C034"/>
    <dbReference type="WBParaSite" id="SPAL_0001136700.1">
        <property type="protein sequence ID" value="SPAL_0001136700.1"/>
        <property type="gene ID" value="SPAL_0001136700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001136700.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29598" checksum="3E5670F74FC371CE" modified="2015-12-09" version="1">MNCCQRNFVYKILRTYSSMVTESKKEKFIKRFSKVAQLINQEEDITDASPLSGRFPRGHVKPKEGDSSVLVPLVDIDDKTHLIYTKRSMTMRTHKGQICFPGGRLDPNETWEMAALREAEEEIHLKKHHIDVWTPMRPISNREMTATVTPIVGYITNPDAVQHLHSVTDEVDVVMAVPIHELLTNHHYTFFRLKVCFTLPYFESRKYKLLYTKHDNYVKPDFYRIWGLTGIITHQFLLNFSPESYKTKVRLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0A9</accession>
    <name>A0A0N5C0A9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0A9"/>
    <dbReference type="WBParaSite" id="SPAL_0001143800.1">
        <property type="protein sequence ID" value="SPAL_0001143800.1"/>
        <property type="gene ID" value="SPAL_0001143800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001143800.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14348" checksum="08F29A2B48DE168E" modified="2015-12-09" version="1">MEVPPKEQNKKIKDKELFDTLMGQLKMYESVDQEIEQSLRALWSTGNYKATEKLIDKMIGNIDKDSSKADRLATPEVKSAVNDNTLLRTLTPFEGNNVTEFKLWVETYDLTVSLAHQTLPNEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0D4</accession>
    <name>A0A0N5C0D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0D4"/>
    <dbReference type="STRING" id="174720.A0A0N5C0D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001146300.1">
        <property type="protein sequence ID" value="SPAL_0001146300.1"/>
        <property type="gene ID" value="SPAL_0001146300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895123" evidence="2">
        <location>
            <begin position="22"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="5">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="4">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="3">
        <location>
            <begin position="333"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001146300.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="61373" checksum="CC2639F88459DB79" modified="2015-12-09" version="1">MFVKLYLLGAALALMPLPIQSYEEYDQKLFPDIPQNINRNTFPIILEVKKPSNMVLVKCPDVGYRDINGGHEFENSNEVVKYKNFVPLNTSLFVWVPLLKESSNSTQFNCGKIIIKSDETSSDMIDWTYDVRWNNVKEDKTKINSNNMDFLLPVTPKECQDGTENLLVVSKDKENDTAVIIDPLDVMNPYANQEFYYFIKPEQNDGRQIIEHCARYRGYKNPPHFNLPDYNDNSTINEVKKININELNYEKEEKIKINLKLGDDIQFYRDEGISLSRMKYTIGGLIDIENSTQQINSSFTIKGFDLVKLVYNHLNAAGYIEVSQVYYFGPASKNFTIEKYFENEVDYSFKPNCPIYFMNVGYLDKVIYDEIEGSIYSLNSTAGIEGRFNITSDFIFFEEKEDRDTKLVCIYKTLDGIIAISNVYEHQDIVHDHQDIVSDHQDVVSDHQDIVHDHQDIVYDHKNIVSDHQDIVSDHQDIASDVNMSVGYSHNFTYHRETRIFGIPGTILGASMLFLLLFLTVVIIIAFRKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0F2</accession>
    <name>A0A0N5C0F2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oligopeptide transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0F2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0F2"/>
    <dbReference type="WBParaSite" id="SPAL_0001148100.1">
        <property type="protein sequence ID" value="SPAL_0001148100.1"/>
        <property type="gene ID" value="SPAL_0001148100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000049">
        <property type="entry name" value="Solute carrier family 15 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="814"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001148100.1"/>
        </source>
    </evidence>
    <sequence length="849" mass="94656" checksum="E1743961CFAA0238" modified="2015-12-09" version="1">MIERNNANEREELIPENASLRKYHPSSELDPEPKTFSEMVKKWPKSTFCIIGNEFCERFSYYGMRAVLTLYLINVLSFDNSKATIFFHAFTVFAYTSPLIGSVLADGYIGKFWTIFSISLIYASGQVILAVSSTISKGSSIHPGLDILGLAIIAFGTGGIKPCVSAFGADQFPAHYTTMISHYFSIFYFMINAGSTISMVLTPEFRATPCLGYDSCFPLAFGIPAVLMLVATGIFMAGSFSYVKLPPKENVVFRVIGTIWVAIKNKFSKSSSRNHWLEHFLDTHNCKTDIKCITANQNRPENRHKCAQEKFVEDVKSLVRVCVMMVPVPMFWALYDQQGSKWIIQALAMDAQIWNGFDLLPDQMGVLNAIFILIAIPVFQAIVYPLVEKCGIKTTLLRRMIVGGLIAAGSFVVAGFVQVGVNQTLPDIPQQNEAFFAIVNGFKGCDATVSIDNYATQFIPANGSLYDNKVEDHLSLYRFKNVNKQLSLTVHAKFNGTNCTNDHDYNVVLNGGETSFLFMSSEGSFKNSVSLDKPQEGEGESSVTINFMIPCTETNKASLNNKKVTWSNCDKSANPNKEIYFGRLAVCVDPPKDINNPCDPRDTGKYYVWKSDSYNKAIATFADGTSVNYTKYQSNDIKRNVWKMYYVNYTLGDSSRTPASTEITAIPVDGSTFTFDGMGGVYQYQIYQSKITQEILLNRFIVVPKNHLSILLQVPQYVVITYVVITVAEILFSITGLEFAYSQAAPSMKSVVQAVWLITVAFGDLIIIIIELLDLFENHATEMFAYAGAMVAVIGVLVILSIFYYEYVDYSEEEKDDEEEESTGTIVKEQLPSVSLQDSSSYNDGYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1N8</accession>
    <name>A0A0N5C1N8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alba domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1N8"/>
    <dbReference type="WBParaSite" id="SPAL_0001191000.1">
        <property type="protein sequence ID" value="SPAL_0001191000.1"/>
        <property type="gene ID" value="SPAL_0001191000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001191000.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45730" checksum="1A70A9DE2C85AF8E" modified="2015-12-09" version="1">MEVDESITFEAVSSEYSDKNKIDISSLSPLFDKLIESIDDNERENLKVYNEAVEKMNTLLDENKKKVVKVYLEAKSKNESPANTIKELNTEIELTSYHTQFHNLVYNVKKQFYGQLKNHFVSIATEIKNNKTPTNLHFNFGPQIKNVDSKTSSEINIINPRKTKITSNTNIFDNKKICRTQFKKSGCSTIINLFDQNKFDYIVFITFQSCYLKEEFMGCFVLCNQVSLKVGCTFESKEYSQQLENYENCDNDYFDSYDNDVSNENLVDSLSELYLGKLVRVLNEIKDPSTSTKKPKIIVLGLRNNDINLVGRIISKKIQSSCLSPNLKILASTLFSLLNFKFSIRYSNSTSKYLERIVFRESFNSSDKIKNKDNYRIIELQYEEFLNNSSEDESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1V7</accession>
    <name>A0A0N5C1V7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L52, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1V7"/>
    <dbReference type="WBParaSite" id="SPAL_0001197700.1">
        <property type="protein sequence ID" value="SPAL_0001197700.1"/>
        <property type="gene ID" value="SPAL_0001197700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034596">
        <property type="entry name" value="Ribosomal_mL52"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18699">
        <property type="entry name" value="MRPL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001197700.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14284" checksum="C5DC12BEA8466EF4" modified="2015-12-09" version="1">MNNSIQLVRSVTTKVSRFGMEVKTRGKFQNWRNPVYVSPHVSPLQVGPDYSFQDGRRLQFTSKAELNRKFEQVQLAKKIVKYLSEIKEMENMYDKGMAEREAREAEFIEWTPKQKSTETIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C272</accession>
    <name>A0A0N5C272_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C272"/>
    <dbReference type="STRING" id="174720.A0A0N5C272"/>
    <dbReference type="WBParaSite" id="SPAL_0001208500.1">
        <property type="protein sequence ID" value="SPAL_0001208500.1"/>
        <property type="gene ID" value="SPAL_0001208500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001208500.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10283" checksum="7741B54AAFB725BD" modified="2015-12-09" version="1">MRVSGAALGKHFGNMGKMYGEYRFGLAPNEQKPMKGFFEQAIVKNFKNYVADQWYYYIPSGTAAYLVYDAAKKINHDSKRKDPSIYANDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C336</accession>
    <name>A0A0N5C336_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C336"/>
    <dbReference type="STRING" id="174720.A0A0N5C336"/>
    <dbReference type="WBParaSite" id="SPAL_0001239100.1">
        <property type="protein sequence ID" value="SPAL_0001239100.1"/>
        <property type="gene ID" value="SPAL_0001239100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001239100.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56658" checksum="A9645F997BAE96A0" modified="2015-12-09" version="1">MSECNVGDVTMDNFFGPSNSLLGGPKDGYLDETLYGLEEQYKPASRKKFNISIFLGIFVFILIASGLFYLIVYMPNDKYNLVKKNAIFDSSSPIHMYQEHRNYQNYIFKPENVSMDILKPLPALTYRPITVTHTLIDEITSPPFVTKTKTYVISAKPSKAPLIVSRIKETHIFRVNITSFNVTKKKVPESTSQAPTERPKLKIEPTILGKRMFNFSSYIQDPYGSTINSYERLSNVAYDVHKNSCDEIKKAGPSSNGVYTLFINKKKVPAICDMKADSGPYMVVQRRISSDVVFWDKTFEDYKLGFGNPTTNYWLGLEHLYQYQEYLRKNSENKDYVLLLRIELRTNPCDSESSSCSQTSIPIPTYFWHEYKMKLGGLDDYYRLNIESIRGNLSTQNDYFVYINNGRKFTTVDVDNDDSPRTNCAQRYYSGGWWYHQCSHTNLNGIYPDPKNSTTKNGMKWRYSSPNKLNSASSVGVKWDVRPDATLMLVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3B0</accession>
    <name>A0A0N5C3B0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3B0"/>
    <dbReference type="WBParaSite" id="SPAL_0001246400.1">
        <property type="protein sequence ID" value="SPAL_0001246400.1"/>
        <property type="gene ID" value="SPAL_0001246400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001246400.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26822" checksum="21CEFBE9FFDAC9D2" modified="2015-12-09" version="1">MNQDCEKNYNEDGILYMIEIKKGNIILRYELPAMNKSFSLLRSIDTQSNFVQFLLINSLDIEYYECIYKYENNDTNLFSIRRNLAFSNYFVKELLSKNSNNSSSSENKIDRSPNVRLIYGISAGFVIFINLSVFITLFIVKRTKNQNFKQLYFNLKKSFNKKSRKDKSNKQSVSNYGISKFKTYTTTFKSTNKDDLSSSTTLTFSDSSKTTSERSPTISENTKSKQGSVTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3D3</accession>
    <name>A0A0N5C3D3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GB1/RHD3-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3D3"/>
    <dbReference type="STRING" id="174720.A0A0N5C3D3"/>
    <dbReference type="WBParaSite" id="SPAL_0001248500.1">
        <property type="protein sequence ID" value="SPAL_0001248500.1"/>
        <property type="gene ID" value="SPAL_0001248500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="57"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001248500.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62532" checksum="7DD10A1B019F36E1" modified="2015-12-09" version="1">MVEETNTTIIEEIDHFEDIDYHNNPQPIRIVESDGFGKYGCNKKFLRDLLLESKYADKKVAIISVAGAYRKGKSFLLNFFLRYLKSLNTIDLQGGTWMETEDSLKGFSWRGGSERDTSGILFWSQPFVLKDKNGEDIVVILMDTQGAFDTQSTVKDNATIFALSTMISATQIFNISQNIQEDDLQHLQLFTEYGKLALEESYNKPFQHLLFLVRDWSYPYEAEYGFEGGKRILENRLHTNEKQHHELKQIREQIHECFERMECFLMPHPGLKVATNPSFRGRLDEIDGEFKSCLETFVEHIFDPNNIIPKSINGSQITCRELYEYLICYTEIFGNDTLPEPKSMLVATAEANNRAAVEKARMVYVKEMEEICGGGTPYMQSAELEREHERVKNSAIECFKRMKKMGGKEFSEEYIAFLENGIEMHWEAYQKVNASKNLFKSMKTPTVLVALLIVNYIGQEIFQLIGIEIFASIFTTLLFIIIIVITVWTYSRYSGTLRTTGQQIDDGVLYLWENFLSPISKQGIHTAADLAIKMNTTSSDKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3P6</accession>
    <name>A0A0N5C3P6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3P6"/>
    <dbReference type="WBParaSite" id="SPAL_0001258700.1">
        <property type="protein sequence ID" value="SPAL_0001258700.1"/>
        <property type="gene ID" value="SPAL_0001258700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895294" evidence="1">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001258700.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12076" checksum="93F2D1AAE84B7162" modified="2015-12-09" version="1">MVFRKNFSILLLFVILSISWKVCKFQPIHGGPYGGYGTFGGFGGYGRLGGYGGFGPGHHFGPPGLRPHGFGMRPPPPFMHHPVGIRRPGPMFPPPLMGPGHHHLFGRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3W1</accession>
    <name>A0A0N5C3W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3W1"/>
    <dbReference type="STRING" id="174720.A0A0N5C3W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001264500.1">
        <property type="protein sequence ID" value="SPAL_0001264500.1"/>
        <property type="gene ID" value="SPAL_0001264500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002050">
        <property type="entry name" value="ABC transporter, class F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="93"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="420"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001264500.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="71544" checksum="9147C8E213B3E0A0" modified="2015-12-09" version="1">MGSKDITKEMNNLDISKEEKKLSKKELKKLAKKAEYDKEIKAMGGVYDPDKKEIFENEVGGIGSSLNVGDQFTVSQQTKTQVQEAQDETSKDIKVTNFDITAAGKLLFNKAELIIAHGRRYGLVGPNGQGKTTLLKHIATRKLNIPSTIDILYCEQEIKVDKTSAINAVLNSDVTRLQLIEKEKELIAELEDGNVNAGEELQAVAEELKNIGADSAEPRARRILAGLGFSREMQEKSCEDFSGGWRMRISLARALFLEPTLLLLDEPTNHLDLNAVIWLDNYLQTWKNTLLIVSHDQGFLDNVCTDIIHLQDQKLYYYKGNYSKFKEMHEQKMREHLKAYEQQQKTLAALKKGGKSKKQANEEIKNKLVQKSNKEKKGKHGISAMGNEDDAPPPELLQRIKEYQVKFNFPDPTPLPPPVLGLHSVDFQYGDNVLFKNVDFGVDMSSRIAIVGPNGVGKSTLLKLLYGKIQPTQGEQRKHRQLRIGWFDQHANESLNGEQTPVDYLVTKFGLDYQDARKHLGTTGLAAHAHTVKIKDLSGGQKSRVALADLALGNPDILILDEPTNNLDIESIHALASAINNFGGGVVMVTHDERLIRETECNLWIVEDKNIYEIDGDFDAYKEEILKELGETIIKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Z8</accession>
    <name>A0A0N5C3Z8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Z8"/>
    <dbReference type="WBParaSite" id="SPAL_0001268100.1">
        <property type="protein sequence ID" value="SPAL_0001268100.1"/>
        <property type="gene ID" value="SPAL_0001268100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001268100.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30889" checksum="DF87CB7D78E92601" modified="2015-12-09" version="1">MPKLYDNVEYFTKEGRKYKNTYENIDSPRKSSYVPRERNRRCKSMTFFTRFGEKTSNIKNAFSKEELDSYSPPSYYLTNYNNDTNNINDKIFYYTSFPSIVECNKSNISTYDKIDKYLEDNKNFKLPPLNCLHLYDKKKNGRKINKIQLYRNEIPSTEDINIKKIDVEIENELRKNKKLQNERKYYECEEENLIDRKIMVNENKRIQSLDRQIDETLYIIDRNNSERKLQPPVSEFYCSKKKYKPSINRLVQMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C480</accession>
    <name>A0A0N5C480_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C480"/>
    <dbReference type="WBParaSite" id="SPAL_0001276333.1">
        <property type="protein sequence ID" value="SPAL_0001276333.1"/>
        <property type="gene ID" value="SPAL_0001276333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001276333.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="45390" checksum="E23840E92811BF8A" modified="2015-12-09" version="1">MKAKINSGVSDRGHEMYLSAIKKALPQPNKLLVTIDGTRNYFKKGSMSLSDEAIYQEFTDGKFVIYNARRRIHEIFRMYDTISGKVYRMMNNVNKNTFLIGLQLHFDGGNSNKTNKDHQIFPFSLRILNLPPGIRNKFELYISFAIYCGIGKPPFELMEEPIRKKFKLCENNSIVLNGREICYNIQVINFTADIIAKTDFLRMKHFKHTYGCSLCFTASTTLLKRAVYISAIGCTLRTRNSMIDDVNYVLRNRHIIDNYHGHKENLPMFFDDIMYPYVITVDWFHSVFEFYANNEEFIVSPLSNGSKEMIDYKIDNNKISRCFTRKLRKLECFGSYKASEMKLIFLYIFPLSMFSIINSGDNIYSKYVLNTFLQIAAVGSLLNNNITNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4A9</accession>
    <name>A0A0N5C4A9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4A9"/>
    <dbReference type="STRING" id="174720.A0A0N5C4A9"/>
    <dbReference type="WBParaSite" id="SPAL_0001279000.1">
        <property type="protein sequence ID" value="SPAL_0001279000.1"/>
        <property type="gene ID" value="SPAL_0001279000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001279000.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="76106" checksum="737EAE455783CC47" modified="2015-12-09" version="1">MLIAIIIVSSILGFLILSLYFRHKYKYDYAIKENNIKVVHVKSSLHDVKDRRCIIPKLDIWNSLVRLYYKSKIIVYCGIEKNDWLYFDPSTQELKVVDEIKEYENDLICTVKYINKINFTHFDITSYKYSSFPISNLKSDFFDIECNINGIEYQWSKYFMRAIIKNEMVEKLRKIKKSRNIRNWNVQIISYGSLSQMAVRRLLPKTVKFFEKTLEGITLEGYNILGNETLNSFIPILTGKTESELLKIRKPFKPPFIWSKFSDVGYITLFGEDSFKNGTFSKYPNIYQNQTINHFLGTSFQYTEKEFGNECFRDTMQHKEWLDYSTSFIEGYNSINISRFSFLHHSSLSKNHLTKAENIDDDLYEYLSYNYNKGNFKNDVIILMSDHGDTSSEYTYTQQGQFEERLPFLGIRLPEEFNNTEYKKRILENLTNNRNALITPFDIYTTLLDIISIPNDSELKKTQSLNKRNLSIIKPIDKNRDCFNAQIEKTWCACTEWKDISNDDNYNNIINVLTNKYMEEINKLLQPQIKYCSLLKLDKILNTQWLVPNKKVLINYDILDENNSTSTNNFIDITEATYKIVFTTKPGGTTYEVIIHLNFVDIKMYVNMWNFSHLKLHDNLGYCMEGKINKLIPYCVCYDKISNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4N5</accession>
    <name>A0A0N5C4N5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4N5"/>
    <dbReference type="STRING" id="174720.A0A0N5C4N5"/>
    <dbReference type="WBParaSite" id="SPAL_0001291500.1">
        <property type="protein sequence ID" value="SPAL_0001291500.1"/>
        <property type="gene ID" value="SPAL_0001291500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000078">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000044">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="260"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001291500.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="63996" checksum="5621EF583B7757FB" modified="2015-12-09" version="1">MKLTDKYFYFILLSIPSFAIQTKNFESQLYEDLLYDYNKIPRPVKNSSDILLVHVGASLIRIIDVDEKNQILTTNVWLEMNWIDAKLQWDPKKYGGIKTLHIPSDLLWTPDLVLYNNAAGDPDITIFTDALVAYDGRVFWHPPAIYKSFCPIDVTWFPYDSQKCNMKFGAWSYTGFYVDLRQLPREEVTILKDKDGSDIEYLERGMDLSFFYKSAEWDLLSLTSERHSVLYASCCGPEKYVDITYNFELRRKTLFFTCNLIVPCFLISMLTTFVFYLPDHKITFSISILVTLTVFFLVLIDIMPPTSLVIPMFGRYLITTMILVALSTVVSVITVNFRFRSGSAHKMSPWIKTIFLKILPKLIFISRPKMTEVKDKKYFIFKGKKFIRKEEEDNIDKKIAASSKLIQQFPFKLPEMSLSTIELPSIYKISEKVKVTTEKMCNNDEETVKISHKKKVEKIIFMNLLKQICFIAKHFQNNEEEAEISNDWTFVAMVLDRLFLIIFSIFNVATFLIILEAPSLYDTKESLNISIPNKPLGQANIYSMSSHKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C569</accession>
    <name>A0A0N5C569_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C569"/>
    <dbReference type="STRING" id="174720.A0A0N5C569"/>
    <dbReference type="WBParaSite" id="SPAL_0001309700.1">
        <property type="protein sequence ID" value="SPAL_0001309700.1"/>
        <property type="gene ID" value="SPAL_0001309700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="336"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001309700.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52556" checksum="73701484E44A76C6" modified="2015-12-09" version="1">MTFKKVENVACVGAGYVGGPTCAVIAWKCHHIKVTVLDINEEKIKQWNSDVLPIYEPGLEEIVKERRGKNLFFSTDVKGTIENADLIFISVNTPTKHYGRGKGMAPDLKYVESVARMIAKYAKDSTIVVEKSTVPVRAAQSIGIILAEAQKRNPQLHFQVLSNPEFLAEGTAINDLTHPDRVLIGGEESTGGAEAVGRLVEIYQNWVPTEKCITTNTWSSELSKLAANAFLAQRISSINSISAICEATGADVGQVALAIGKDSRIGSRFLNASVGFGGSCFQKDVLSLVYLCESLNLKEPAAYWASVVEMNNWQRKRFSHRIITELFNTVAGKKITIFGFAFKKDTGDTRESSAIAVSKHLLEECADIHIYDPKVLESTIRFDLSNVITNKGVIEKNVTVHKDPYEAVKDSHAIVVLTEWDEFKTYDYEKILNSMVNPPTIFDGRRILDACKLKSLGFRVFTIGTTPTQSYSLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5J9</accession>
    <name>A0A0N5C5J9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrotrans_gag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5J9"/>
    <dbReference type="WBParaSite" id="SPAL_0001322700.1">
        <property type="protein sequence ID" value="SPAL_0001322700.1"/>
        <property type="gene ID" value="SPAL_0001322700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001322700.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44437" checksum="436B7A3BE8E32DB1" modified="2015-12-09" version="1">MNKETEFKNLLDQLKNAGLLNADIETTLTNHWANEKYDAAMTLIDSLRNMNTSTTKRKPSVHLLDSATDTTTHEWSMPITKLVKTEIHQGIPLSRHELKEYAIYGTETNSPTYRYHNTAFLDKLQNCTAQNSAEFTLWCERYELTMDKAHAMDDLRERNRMKLLFLDNFLSGRPSQLYRAAIHYYGLSDMTYKEVVNYIAGKLDTPINQMRANRERLRFYKDNENFEKHFTAFLNKTVATCGISMSTILGNTIVGTKGTSSYELQKCEQSFQTLMKMEFLYTLLRKVGEQLEPYVNKLTLLEIKDRAGELIIREKERLSRWQRPDNLPSHQYRSGGYKDKPIAYQAKPNRPGFNNSRINIINPILDEHKDIRNKSADEFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6U9</accession>
    <name>A0A0N5C6U9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6U9"/>
    <dbReference type="WBParaSite" id="SPAL_0001366400.1">
        <property type="protein sequence ID" value="SPAL_0001366400.1"/>
        <property type="gene ID" value="SPAL_0001366400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001366400.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29556" checksum="C41D665238D2573B" modified="2015-12-09" version="1">MVAIKPQNNLTLLFNDEFIKSTTLSTLEKINITDKNDVMHFCKRQLKISRVACCNIVKLLNDTNKLPFCDFLISGQQTLTINNTYNKPVYLEYPNDVHEDHVTFIFGIALLISIAGLCTFILSKLTRPNMFGRVPISYMTNSSQANDCRHLMWLPYCNYRGSSMLLYLRGVTCGNGRSSNVTGSNSTSLSIVSQSSLNFLPSYQSAASCPSTTPMTMSTIISPISLPPPAYDEHNDDQITPNNKFDIKSVNDYNSNVIPLLGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C777</accession>
    <name>A0A0N5C777_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CWF19-like protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C777"/>
    <dbReference type="STRING" id="174720.A0A0N5C777"/>
    <dbReference type="WBParaSite" id="SPAL_0001379100.1">
        <property type="protein sequence ID" value="SPAL_0001379100.1"/>
        <property type="gene ID" value="SPAL_0001379100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="310"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="436"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001379100.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60098" checksum="9E08590AA8A1B0DA" modified="2015-12-09" version="1">MSNTKILVSGDVKGNFEALIKRVTTVNSKAGPFELLFCVGEFFGDKEEDNEALLNGEFKFPISTYILGPCNSLSEQYFPEDGGYLTENLTYLGKKGMFFSTQGLKIAYLSGKESNELTKSTFDKSVVNDLIYPVKALHGFIGCDILLTSDWPEGVTKFSNNIPKEVPNGSTLISQVATALKPRYHFAGLHCHYERTPYRNHRVLLDSAQHVTRFIALNSVNNELKEKWLYAFSMTPLTKMSRNELVAQPDIVSEFPYMDIITDIFMEDKKKEYESSSAKSYSKFDFSYFEEEENNRKRRNDGNSYEGNEKKSNAPCWFCLSNVDAEKHLIVSIGTHCYAAMPKGPLNSKHILIMSINHTQSLVAASQEVRDEVRKFIDAFTLLCAQDDQAVVVFERNYKTQHLQVNLVPIPNAAVKYLKTSLLTAASVKDIELTPLDKDSVIWNEIEEGTPYFVIELPDGSKYYTKKMKNFPLQFGREVLCSEKLLNNQYKIDWRNCTMDKIEETSVAKTLQQEFKSFDPFIDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7A7</accession>
    <name>A0A0N5C7A7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7A7"/>
    <dbReference type="WBParaSite" id="SPAL_0001382100.1">
        <property type="protein sequence ID" value="SPAL_0001382100.1"/>
        <property type="gene ID" value="SPAL_0001382100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014:SF1">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895523" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001382100.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23898" checksum="43BE76EDA3EE1A10" modified="2015-12-09" version="1">MKNLSPISILIFFALPTLVLSCDSSSYDQVRGCYKTFLSFYNMTVGINYTLPNYESFAITRGEFEAGKTTEHMKKVCNIQNSLVSCLGSSNSCINGNDMSKIFYFTDEDNLMYTSDYYIANYECTTAYNVTIGQFNCISTIGSIGYSALSDCVDKLMSDIKSEGICKAQIDYTTCLQTVYQSYCGSDAGNYICNIQRIGLTYELPQCINELPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C837</accession>
    <name>A0A0N5C837_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C837"/>
    <dbReference type="STRING" id="174720.A0A0N5C837"/>
    <dbReference type="WBParaSite" id="SPAL_0001409300.1">
        <property type="protein sequence ID" value="SPAL_0001409300.1"/>
        <property type="gene ID" value="SPAL_0001409300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001409300.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10331" checksum="61212DE57D3A38F6" modified="2015-12-09" version="1">MTDRKAVIKNADMADDMQTEAIECATQALEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C863</accession>
    <name>A0A0N5C863_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8J6</accession>
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    <sequence length="120" mass="13754" checksum="FBD3E1D90EF35EB0" modified="2015-12-09" version="1">MSINIENVTTFPSQSNYIESNNNDKLKQSLPSYNEVINSSEFNDILRNSRYSRLQYLVPKISCANEHPPIFTAMPHQDIECGRNKNEKIKFNLFAISIFLIIMIPAVFILIVIVTNTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8P6</accession>
    <name>A0A0N5C8P6_STREA</name>
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        <submittedName>
            <fullName evidence="3">C6 domain-containing protein</fullName>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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    <sequence length="138" mass="15964" checksum="E97C6E73B79A48FA" modified="2015-12-09" version="1">MSFNKGILLILFIFYDAYACISFLRRQSLENEFECCPHVDEYNLPRSDPPAYSTSYGWSNSSGLKYYEERICPMYAIYECNLNKNKDGTKVMIQFVKNNDTVIYEDVGEEHVAILVSCVNKEWVLNSQTFTSITCSQT</sequence>
</entry>
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    <accession>A0A0N5C919</accession>
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        <submittedName>
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        <name type="scientific">Strongyloides papillosus</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
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        </source>
    </evidence>
    <sequence length="1335" mass="150140" checksum="656244E992785161" modified="2015-12-09" version="1">MKLIRMPLILYKSVFLLIFYLSNIICQINIIHDFPQNVSTLIGSDVTLKCSAIPDSRAQFTQIQWKDSSNFLLGTQTPGTLPGHDGRYSYIRNSKDELNLNIRRVKLTDDGIFECQLVRPGRKPQKAPAYLEVLVPPTNVYFVNYASGTTLDIREGTNLNITCASSLSKPKTDIKWYINGQSFEGEDIEEWGEMYGNKTISSFSSIVWRPSRGDAYKLVTCEGKHDKTNTKKRSNVTINVLYPPEKPNIIFRSNSGSKDSIRAGDKVSLLCIVKGGNPKPIVSWYSNGIKIESDYEYNESNKETQSVYSFTAEAVDNDAIYECRASNGIGYEYSSQKIELSVMYKPLKVELLGKPAIKPGENLPLQCISRKSNPPAVITWQVNGQEVQSDNSRSGNLIGSTQETISNISLNYNDIFNTNGEVIVKCFARNVMGIAEEQQLIRILSPPSKPEIFGVNENHYNEGDYLNLTCESRGGNPLASLSWHRGIEKLNSSQTLIAGDISQSIISLKIDRSMNRRPIRCEAENEALATPYEVSKTIHVVYPPRHLNIRVADPSRNYVRASEASYLICTSILSNPAPHITWEINLPKDVQPKVMHGEYLKRNESEYGDWFIENRLTFTPTEEMNGLSVQCIASHSNWKEPVVAKYTLNVYYSPKINYYQDKISLQVIEGEDFRENLTINANPPVSSWLWKKGGVPFAGRVGGIYAHGNTISGQRISKKDSGVYTLVASNIVGNANTTVVLTVQYPARIVHITSPIYANEGENVVFECEGEGEPRTDEMLKWFRNGKVVGSMMREQKRAVLRVNATQSNDGKYTCIADNGIGKPHKQDAYLLVKRAPIAIKDNIARRAAGDIGSTASIKCKATAVPFAYFKWIIEGDKRPVNDNSTKYAFYDRQLDYTTFESNLYIQNVDESDYKKKITCIVANQMGEDKVEISLGPLTFPDTPSDVNLIDVTNNTLSIGWLPGFDGGSPQHFEVRYQSIATKESYTLNTSSTSINLTNLYPLQSYQFQVRSHNRHGGVSDYTIPKIFHTISIDGSINEIKPYTFSIAEVPKWIIITIILAVIFCLFINLILICRHKRNDAKKKIEEKTKMMRNLQSCDGGIINGIQKYGTMTPCTIRKPLTDLRHPSSQEMLQDMGSEDETSVRTMIENPQHSGNFVHVSQPNYIDDHVMVQYDIDSTMYADMMRRNSPAILSHIPQSQYDVDFDASIPRLMTPSYVPLSIYNNNGEVTNLANNKMATESYRDIKKAFESPGQVKRVCHQHSTLPHDVNTLRSQGSIPPPSDEYQSYQYNSETLNNNRRYVPRSPQVLSTFGQPSTTTTFVMGNDYLVSDGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Q1</accession>
    <name>A0A0N5C9Q1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C9Q1"/>
    <dbReference type="WBParaSite" id="SPAL_0001463000.1">
        <property type="protein sequence ID" value="SPAL_0001463000.1"/>
        <property type="gene ID" value="SPAL_0001463000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000389">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="830"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1198"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1273"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1426"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1588"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1658"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1820"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1300"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1616"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1675"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1820"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1847"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001463000.1"/>
        </source>
    </evidence>
    <sequence length="1877" mass="212564" checksum="5C0513747A021E1F" modified="2015-12-09" version="1">MTLGSGGHGASSRSNSRNNYRAGKYSTSRMKLTGGGSSIAGTGGTHPLGGHPLKSADQSKRQDIKHRFEITKKLGSGTYGKVSLAYDHKTEREVAVKLIKKSAIENKADLIRIRREIRIMSALQHPNIIQIYEVFENKDKIILVMEYACGGELYDYVSKHGSLQEHEARRIFRQITSAVLYCHKHKVAHRDLKLENILLDTDNNAKIADFGLSNYFDDKRLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYYEPDTPSTASMLIRNMLRVNPDRRADIDDIASHWWLNLEENMPVIQELPENQITDHTPLTEREETMVVQDLADETDVFMEFGHLSSETRKKIEEFRRRRKEAEEYNENSPIKPPKAKKLNGNDEPEMTSKEKSLRDTEVENEVKSTEIKEEKDRDSPTVKLDDLFDPLERLRQLENRLNTNRTVTNKPDKNICKNSRSRSEKVSDNECISSSNNISLNNQAPAFTSFSESKEQRRNESLTNNSLVQRNSHVISSTSRTREWSHQEIDSLNMLMNQVLEQMEKGPVSLNTVARIKAHPHYDQRPMVKELLESILAAQPPSVQKQASKIIQQQSEDIIRKQMSGNTMSSTLRNKEKNKDIIINEQLSGSGKKNSNIPLPPEKSMIPNRPNPFENEEVDNKLHIKVSTKNNSEKHKLESGHRPWHSVEVGFESDNTDEKDSDNESESEVGMVIDESSKKKTITNNDVTEVTVQDTSFEDATDDETQLSEATLHTEKTPESRKIVVPEAINEGSETDHASELEDEIDEEYDEEEEELDSDIEELADVVEQTVSSASNDKDKDIHIPIDGSDFLTKPYNSRQSGKITHTSSQDIQESDSRLSNNKSLEQSNFKTPVQDSNYLNTFDRGLIKRQSKGKYQLNHVDLYGRGVSTESETPSMFQQKRRIGGPQPPVEQCPILFDKVSIQCPKGEYSSKYPINMNRRETAISSVKQDFGSTKKSNKPISRTNETVKNNAPATTFTAKKYIMQYPNKLEDSDDERINEKIIREKRQQSVKVQNTQVMDGKSGNQNRVSSLPPRSPPLERSSEGDSEYENQKSDKDINNERTDSELEEENDTEEFDEEFHPSYKQTSNILGFKTTENNGFKDNPSIHINNQPASYKSPTLINKMQNQQKIYTSQAQNSLKNTNKNEANSNNARKKYATNASLQNNNKSKESALNKTSKDSSSSPSGGNDEYNGMQKWETAAAYIRRKNRERRQRNQTIAITEEAYLRAKASFGQRSTEHGESSEDSLPSSPSHHTPTGYTYDNNNHISGEQNLRYGMGQMSINRPYSSGYNYPSASGYPGYTGSCSPYSSKKHDDYHYTHSNPHYSGVSYIQNPQYGGYRDQYKSRGIDRRKSFHELTPEKDYSDDQFGSSFGFDRYRYSPNIQQYQPANTNPKHYEDEFSSSSHWSSDSKRYSSSYQMRNDSDIRGYGTNNIRPLSNNWNNNSIFSPYGYERDRSIGNYASTAGIGGYRSTRHDDSYNYPKRNNYDNDTRLGGYGHYDYNNTSSSPYLINPSTNIMGYNNKGDGEERSSTKEGLFSRLKPVTKRVASVLGDKKNRPRSQSNDRKFSASGRSGTSEDHTELNRHTTPELNDKSSEYPYLNFHDSSAGGLTRMIIPKEPDINMTPGRGILKNKPSSEVETRKDSNSSTGGPASDRRSHNFEVYDVETAARKRQLSNINRRRTCDIRMGPDGKFITNTSYGGTDDDYKRPRSPIEKIKSFFRKTPKDNSIGSSNIGSGVGGKSTTYDYSGGYSRHDGNSSIGSASSSRYTSGTDKIFGSFPTSSNSSRLTTNHGSSQYNNQANKYTSGMSSSPYAPGGSSSRYMPSSRNWHDDTHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAG8</accession>
    <name>A0A0N5CAG8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAG8"/>
    <dbReference type="STRING" id="174720.A0A0N5CAG8"/>
    <dbReference type="WBParaSite" id="SPAL_0001489100.1">
        <property type="protein sequence ID" value="SPAL_0001489100.1"/>
        <property type="gene ID" value="SPAL_0001489100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="4">
        <location>
            <begin position="102"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001489100.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="73668" checksum="967578500F341A5C" modified="2015-12-09" version="1">MKRSLSESKGNKDTKSNNGVDVYDFVDDDHVMEKPKKICLTRSSSSNNNPKLDNPFQFLKKSRNPVMFKHTFNGSDPIVISNTEVKKSNSDEISLVRSSGIGENYGEPSTLSVEGRSPQRVKENGEMSDHKNDVYYVVQGLRDQSINIKILSGIHLARKCIEPQFRHFCRTQDVFDLFLKHTKDLINTSPSMALVISTVLYLLSRDKEKFPYSDRAGEAILQLMKVEVIDSDDYKKAKDKIKAILEKWFETTNSMSSKQIKFQLTDEMLSPKNLALEALVFICISNGSSKFRDTIKTNGTLEWIIDELGVVTNECIMNNSLNCRKLNILLRIIQNMSINHKNNKYFLITHDSNGCLKSLEKLFTFFCRTIEKDCSKEEPMKNELSQTFQLVLNILVTLTEENEISSSILGKSDGFLKKLCDIIFCWGPQNISEKHKFSITIACSGCLANTIESCGKNRKIIINEKCNYFDGENNDVQESTILVSFAKHFKYWESKITLIDEDMDNMLDIENDLEEDDTLISDEEKSKDGRGDIQERNDMLKLRMEQKERDCDALFTEAADKYATSHMEANLIASFSAINLGLLLQDNEELADEVRKYLVNESFAPIINLLQRYLEFTSHINQSGSNACSKAINQIIENLGNFDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAI6</accession>
    <name>A0A0N5CAI6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAI6"/>
    <dbReference type="STRING" id="174720.A0A0N5CAI6"/>
    <dbReference type="WBParaSite" id="SPAL_0001490825.1">
        <property type="protein sequence ID" value="SPAL_0001490825.1"/>
        <property type="gene ID" value="SPAL_0001490825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001490825.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12776" checksum="EA00CA858ED0B0A4" modified="2015-12-09" version="1">MTNFFRRFIPNYAKRTEPLRHLLKKGVEYKWTVECRKAFDSLKQALSSSPVLSSPKETGEFILQTDASYLGIGAVLFQKQPELKVITYTQKKNGKHFCVKCNKFFPLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAS7</accession>
    <name>A0A0N5CAS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAS7"/>
    <dbReference type="STRING" id="174720.A0A0N5CAS7"/>
    <dbReference type="WBParaSite" id="SPAL_0001499600.1">
        <property type="protein sequence ID" value="SPAL_0001499600.1"/>
        <property type="gene ID" value="SPAL_0001499600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF428">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001499600.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="33390" checksum="D1F99E4DDB019618" modified="2015-12-09" version="1">MMEQYKESTEQREAKRVAFFAIVVSTAAVIVTIVTLPMLYSYVQNFQSHLNVESDFCKTRSRDMWQEMNMLNGVVRQKRSARGPWFYGETNVEGPLRPEGGNYNAGLGPGSSGGSGAGGGGGGMTGSTQNIVRETQTCCSCQQGPPGPPGPVGDDGPVGSDGSPGKDGEHGRDGQVLPSALATSPCVICPTGPPGPVGQQGNKGPKGPKGDNGKDGENGRDGEKGLQGPPGIPGPIGPIGPPGPKGTPGRIVKVNGPPGPTGAPGPIGNPGPAGEPGEDGTSKEGPQGEPGDDGAPGPAGPQGQEGLPGPRGPTGEEGTCDHCPIPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBD9</accession>
    <name>A0A0N5CBD9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5CBD9"/>
    <dbReference type="WBParaSite" id="SPAL_0001520400.1">
        <property type="protein sequence ID" value="SPAL_0001520400.1"/>
        <property type="gene ID" value="SPAL_0001520400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="648"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1572"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="6">
        <location>
            <begin position="1937"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2095"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2105"/>
            <end position="2130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001520400.1"/>
        </source>
    </evidence>
    <sequence length="2137" mass="249763" checksum="C2502DD116C02E16" modified="2015-12-09" version="1">MNRRISNDISRNEEDSVENNFSNSNLHHVEECDSDNIRHMENIYSHKRKNDQIELNAKRKKSNIDICDTTEIADPNEITLIEPCESSDIFNGFCSDENTDKVVEKVKRVYIRKDNFDFNHCLYKELGIINNISLQNKLSASELIASNIGTDDLSDNEEHFLNITKALKEKELQSNHTLSIRNMDSIKQNRQYTLLENINTFLIYSYDYKESIIKNSSEIRKLSNDMPTIKQKLHSLGEKKKEIYSIVWKNTLYLASQLGKNIVADRVQRFNLNDHQLDESDIDYLRRAIGGYKYHFYKYGSDVKGYYSFNKVFTVAFHIFHSPIQYDETLNCSFEDYIKQLAKEKEETQKQQELRYKIEKKLFSNLYENSTFNEEANIAASSNNLFREEIDDATDIISRNRQMLVDLENGYNFDVIDRDPIENVYYKIGCLAKLCDNNCDLITLDFIEEIFTIIIAFQDKNNKMQTLFAILKYIRDRNFMDKLEKYMICYSRLRGFHRRLGEIISQLTWISKINRFYNDSTLNDFSKFNISLRRQLCVKSITYTSNEIDFSVNIETIERLRESFKKIDFQICSLCERLLFEQDMTLLTEGGVVSGRLKKFIPLSEVDGIKVHSLKEHIGRNNNNFQNSMDDYVCSQCYKFNLIEKNRNTPPKASLYNNLYFDIKPNELKNLNYIEKLLISKTWCVQNIISITEVIGTHTKIKAVKGYAICFNIDNIKSFAEMLKPGTRQIIVQNKTNVGLTYSNVVDVMKVYSALKWLKNNNPYYKDDVLPDINNENQKDWIHNNIKNQLIFYNSGFDGSGCEILEYKSYISNQDYMPYIFEDGVTSGVKGDVKALFDLKYANGNIGRLTDDRSIVTAFPWIYPYGRFSPYYHRPSKITTAYYLKCISRRADRKVVKDPQFIFALEKTEQEAEGRRNIQTSLKYEGGKNFLANDLGFFANKGKLLSAFTTNRLSDAYWKKITNKLIVIETFIGPATWFMTLNPAAKDWPEVTDLYKKYHDAEFGNKFNLEEEIAKDPFIFNMFFQKKVKLLLKELIENPLILGRVVYYYYKTEYQQRGPPHCHFLLWTEDGMKLDINNDKEVKEFLDKYVTCSIYKNHEELHNIVKKYQVHKCLSMYCLKKKLKPIPEHKLKQPAKDLKLRDKTYKIVKCRFGYPKKHRSETTIFRMDPSLEAVMEICKRPHKAYELQRDLGEENINPYNPTIAMIFQSNTDLTFNALQITPTGAINYAAKYVSKTTLSCNEEVNNLMKDLAYSKNKNITSILFKLAYSLHLRPQPFTEIMDAAIGNKTHDTSINVYYCSTENKENRVRITKALKDMEGECIGLTTKENIYDNYYINRPKVLEDSCLFQILANFTCRNINEKNKIRNTNINFNESFDSQSDIIQTEDEKESRNIYYFITKNTNKRHISSPCFQHSSKIDYPIYNYQTYLFPVKIKLLNFFNGLKIIDTDMENDDEEDVYRRYCLLFVPYRSETYSESSKERFLNYINRLKQNHPRSAKDIEILINCANNYLKKQILQNDFREYKKQSEERIRHLLREEGENIDEIGAYEDDDIDLLKNVKSVNHLLRNVDSLNDKQKQIFDKVKNCVINEIKYGSDERCRLLVDGPGGSGKSYLIKVLSEYITYLCRSNLNEFEQTYPNVLICGPTGMSANQISGKTAHSLFGIPCNANFTYIRYSQLSSGKLTKLSERLKHVKLLIIDEISMIPNDLLYMINLRINEAKHSDIRLFGNLNVLLFGDMMQLPPVSNMANRPMFYKEIEINKFNKIFSGTFSLRSAFIDFKIISLTENVRQANDPRFGKILNSIRFGNCSDDARSLLDERRTVKTLFETYMECMNKFEDCVIISPNNKTINETNTFIIKSIAEHNEIPCYKISCKENLKVVKSSEKRIYMKKEARYSHNPIIDITLSELQSTLKVFAKKTNREENGLSKDLYICEKSRVMLTRNKNVRMGLCNGARGYVVAFKTVKETGTATNISVLDVDNIIVKFDNCEEPVPIKPCRYAYVQGKTLIQRIQFPLQVCYSMTVHKCQGLTLPSAIINFPTGPLNKINETPGLLYVALSRVKTSDTLFIYDLDIDKYNNANMENKEQIEKMSGIQENLNIEKQGNEQDEEQANEEDEEQYEDYEERDMADEYYDRYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBF0</accession>
    <name>A0A0N5CBF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBF0"/>
    <dbReference type="STRING" id="174720.A0A0N5CBF0"/>
    <dbReference type="WBParaSite" id="SPAL_0001521500.1">
        <property type="protein sequence ID" value="SPAL_0001521500.1"/>
        <property type="gene ID" value="SPAL_0001521500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001521500.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17629" checksum="C5E137C75ABCD360" modified="2015-12-09" version="1">MILDMGITIIALKSKHSIDILVKREKVDNEDTGDCVGSDEDNERKEEGFVLIGKESTCNRCKRVITVLCLIPCCPCFENAQSDCIKYFNGTHEAPKISILHQLSGRSQLMAMRLLKHQIQSTQQSILMEKGILTWSSCSFCWSWFLTMGRKDKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCY3</accession>
    <name>A0A0N5CCY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCY3"/>
    <dbReference type="WBParaSite" id="SPAL_0001573100.1">
        <property type="protein sequence ID" value="SPAL_0001573100.1"/>
        <property type="gene ID" value="SPAL_0001573100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001573100.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19721" checksum="66CB4EC2C11430FA" modified="2015-12-09" version="1">MGVPVIHDIKEKFVNVFTDASNESMDIYIREFDVKISRKFGKIERDWHINIKELHAIKISMDILLEELRIRKIELHEVNIVSHCDNMTARSWVLKKKGDSELVHDIVHKIVTCTSARPQFSGGSFEQGYGVNISPYRSPMEFNGAEFNERKRRSSKGWPSHPKNKKVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEI0</accession>
    <name>A0A0N5CEI0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NRF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEI0"/>
    <dbReference type="STRING" id="174720.A0A0N5CEI0"/>
    <dbReference type="WBParaSite" id="SPAL_0001626800.1">
        <property type="protein sequence ID" value="SPAL_0001626800.1"/>
        <property type="gene ID" value="SPAL_0001626800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF14">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896007" evidence="3">
        <location>
            <begin position="22"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001626800.1"/>
        </source>
    </evidence>
    <sequence length="752" mass="86569" checksum="D43C794FB20266C1" modified="2015-12-09" version="1">MKILFITIFLLFNNLNIGCLGCILCHKYTPKPPVPLDEFRLPSIEFLLSTKDQVIEYCDNTSVFNLTDNCGKQIKKLFCAVKDLWSYVTNECPQNEDECKKCQIEKAKKYMESSWFLAWFDSIGKMPSGISDGNYHWLGDYEQCALLSEGNFFESRYCMVKFELKGDIKQFDEECQVSTHFEAPNINLGICTPAYCTPEESKTVLRSLAPMPIEINCEPPAQLSTKSFIFIFILGMWIIFVLTMSILEHSGIDEILNLKYITNAVSIRKNFRQCFSTKRPYEKMHTLDGIQFLSALILVIGNVFNIMAPYMENVGFLYFFNKRIASQPIINYLYHVDGLLVLSALATTLRLYVHVNSIKNTIQLILDRAIRIFPIYAFILCFTTFLFARLGNGPMWSHSVMADRCEKEFWKELLFINNFFGYQETCLDGSYVIANAAQLFIVLMILLYINKNFPKASIYSASFLIIASIVYTFTTTVIYKTPPALIPTHPFVGKIATEDYINKIVVQPYSHIGPYFVGFLFALFIVNESFPKIVDILLYIGVLIITVLVIYTPYLFIVFGIDTHWNILFAIYSTFSNLLWSSVLLILIYLLDKKTNLISVFLSWRIFHPLSKLSYVIFLISEPVALYYFSSLHRPFHATTMAYLSVTMGIVVVSIVLSALVDVFVSRPIRNIFKFSERRKYLTESNSHISQEGNSKYGIEMSLYKRNRKPSDLQKKGNKKLNIKESDKIKHQKGCPDYESDVDDISIIEHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH88</accession>
    <name>A0A0N5CH88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001720800.1">
        <property type="protein sequence ID" value="SPAL_0001720800.1"/>
        <property type="gene ID" value="SPAL_0001720800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001720800.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8477" checksum="9AB1655E1201960F" modified="2015-12-09" version="1">XTEIFIKHVDFACKFGIQPQMKMLGEDHTFIESYNLDIIALFLLTISFTLYSIRKLAKCAVRRIYKHKIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI67</accession>
    <name>A0A0N5CI67_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI67"/>
    <dbReference type="STRING" id="174720.A0A0N5CI67"/>
    <dbReference type="WBParaSite" id="SPAL_0001752600.1">
        <property type="protein sequence ID" value="SPAL_0001752600.1"/>
        <property type="gene ID" value="SPAL_0001752600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001752600.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24719" checksum="D97ABE7EC93B797C" modified="2015-12-09" version="1">MNILSLSKKLINRFLIRTSSRLCSTEPLKKDCLDREIYHGSSTVRLVMNSLKNRNTLSLEMSNILYQELFYINKINKVRSIIIAGEGPAFSAGHDLKELTTEKGSEFHKEVFSRCTQLMKLIHSMQIPIIAEINGVAAAAGLQLALSCDIVIASDKSKFSVPGVKAGLFCHTPGIPLVRNIPQKVAMGMLFTGRSLDSEEAMKAGMVTKVVPEDQVKFEALSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIM7</accession>
    <name>A0A0N5CIM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIM7"/>
    <dbReference type="WBParaSite" id="SPAL_0001768200.1">
        <property type="protein sequence ID" value="SPAL_0001768200.1"/>
        <property type="gene ID" value="SPAL_0001768200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001768200.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14145" checksum="D0F90B895003D3A8" modified="2015-12-09" version="1">MTYNGIPANGATVYVDQKNLLGISRSLAKFNCDNRGCFYVKAKGYIFSRYDLLIRIRYSYLDRWWLCQIRASLIFPIKNAKKCTNKDKTADLGNLDLITVPGIEKTCQLKHCSKNKPCRIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CJ02</accession>
    <name>A0A0N5CJ02_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CJ02"/>
    <dbReference type="WBParaSite" id="SPAL_0001780900.1">
        <property type="protein sequence ID" value="SPAL_0001780900.1"/>
        <property type="gene ID" value="SPAL_0001780900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001780900.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15889" checksum="729B080672B1B9DC" modified="2015-12-09" version="1">MPDSEEERLFCRLISDKHAGKIKTNIEIRQHLINLKIKVPGQTCLNKIIKSYETRNSNDIRDSVGVSKTKVANSTCSTQSSALSIDKNEKEYKIESFNNFKILGLIDEGPYIKNFIAQRVNDAAIFVKESGYNVSNIVGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2X1</accession>
    <name>A0A0N5B2X1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2X1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2X1"/>
    <dbReference type="WBParaSite" id="SPAL_0000042300.1">
        <property type="protein sequence ID" value="SPAL_0000042300.1"/>
        <property type="gene ID" value="SPAL_0000042300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893799" evidence="4">
        <location>
            <begin position="23"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000042300.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="86371" checksum="E9565803CD8E9992" modified="2015-12-09" version="1">MKIVNLIIITNILCLFLPISTSIEFSGWFECGVGCRCSDRGSNGLTTHHVICNWRKIESHLIRSFPNKYNASTMEITCRSHKSTDQSYSVDVEMFEGFRMLNFLSISNCWLGNLPPTYFSYLPTLTTLRLEHAKINDVHPMLFNSMPNLMVLSLAYNNLQTIPVAINSTKSLINLTLSNNTIYFLPDFLPNLKMLQYLYLENNDLVEVRTSSLPNSTISLFLRGNKIKIFDHHLSNLPKLDTLDLGENDIEYIGSMWKTTNCFPITIRKLYLDHNKIYKIEDENSLKDMKRLSYIKLNNNLLEIIIKKRLTFHDRTIISITLANNPLKCHCENEWIVSQHNNTNNHIVIGDLGIVTCLDMLVPQKIHRIINASNENNILCPYDHICIEGCECCMSQKVCNCSLNCLPDCDCYYSRKIINLTPLSNKIKCSELRKDKISLLPKGVTELHLLKDGHRSSGLMTIPDMENLKVLNMSGGNILSLEDVDLRRFPKLEVLDLSYNAIDSLEDTSYDNLGNIKHLNLKGNFLKEINNNFLQYVSRKLEKVWLSGNGTRYNCDCNDNYKTNYQKWLDSYSNNKKVEDLELMRCRSGVSKYDLNMTQFLLSYPNVCLKEKTTTSMMNSKYESSSKSTILFNVTGNIKREKDRKIEVWRSDKEDDQNFSKYDVPLVTEYPLSRKPIFPDLSDNNMISIAHSINMNQLMGSIIAFTVLVLVNVIFYMFIQYTIIKLSNRGHNPEFNQGPNAEMIPLREVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3G9</accession>
    <name>A0A0N5B3G9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3G9"/>
    <dbReference type="STRING" id="174720.A0A0N5B3G9"/>
    <dbReference type="WBParaSite" id="SPAL_0000062100.1">
        <property type="protein sequence ID" value="SPAL_0000062100.1"/>
        <property type="gene ID" value="SPAL_0000062100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="146"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000062100.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="41822" checksum="725F3ECFA831097F" modified="2015-12-09" version="1">MKVLNNIYVLQIYILLWSNIRGKSRFYLKCPLYKECKYSLSRRDVKVADVLLFKDLKSDQNHIPKYRDPKQLYVYVNFEPKLIIDKKIKEGYTWNHKNFFNMTYTYSSRSDIQKTYYGEWTKGPIDKCFTKYYKNISVVPSINDIKKKKKYIVWTVSDCKTASKREEDIAMLKKFIPVNQFGACNHRVFKYGIFSKQFQNLYERHYFYVALENSDCEDYISEKYFSRVHFNSVPIVGYRKRYEKIAPKNSFIAMDDFKSPKDLAEYLYFLINNKEEYLKYFNYRKEGWKIYDIDNAMNNVCSLCKKLVEMKKSGQLQKFQRTYYDAREDFLSWTQCKENGRIWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Z7</accession>
    <name>A0A0N5B3Z7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000080000.1">
        <property type="protein sequence ID" value="SPAL_0000080000.1"/>
        <property type="gene ID" value="SPAL_0000080000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000080000.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15784" checksum="4068E1D8CE1F7BB9" modified="2015-12-09" version="1">XCRKLLIDSIVETLKVRPLGICNNLDFLASAHVKALYWDGNSNITTRGVLTAFPNLAVIVYRDCKFTRSVQLPGSIRIIICCTRICQCNLGKIRGWQRPYSVKCGPNVIGGPASLYFKTKEDFLCFGDYSGVSRIRHTQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B420</accession>
    <name>A0A0N5B420_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B420"/>
    <dbReference type="WBParaSite" id="SPAL_0000082300.1">
        <property type="protein sequence ID" value="SPAL_0000082300.1"/>
        <property type="gene ID" value="SPAL_0000082300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000082300.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7906" checksum="46DE8C4F6A4E1F57" modified="2015-12-09" version="1">FISFGRLFCKHMSKSYMDEQMKDVHAPAEIRTNVALSNYKPFSNAFKCELNSKMNPEDKCELWKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B480</accession>
    <name>A0A0N5B480_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B480"/>
    <dbReference type="WBParaSite" id="SPAL_0000088300.1">
        <property type="protein sequence ID" value="SPAL_0000088300.1"/>
        <property type="gene ID" value="SPAL_0000088300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="337"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000088300.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="77890" checksum="2B05D877D99F7D32" modified="2015-12-09" version="1">MFARYHPLKKVEDPPESFISAIETFSRLEFYSELQSLLSGKNSEFFYSSVIERYSKLSLVPTYSSTFSIKSSYFDVFNFNTYDIAMINHVLETAATYHSIVERCTSSANNLKDSLAEVFTESIVDCILGDYLNEIPEDPVPEQLFQFSLLWRNRIVYFNNVHLGLHSEIGLNILNNLYKEYTSKVAQTWESEALKRILYNMYKRFMLQLKEWLLYGRLPYHNKDWIFYQRQEIPDCRKWFEWISPRTKLFPISMKYIVNIFDDFLSIGKAQLFLQEANYRSKFKENVHRMNELFDELKDPSVFYEIQSRYNLCSIAGKMKKIANDYIIERIFQDEYLMDHWKAAKAYFLLTDHDVCKRILANVENCVEITLDQINFNFSKIINSCDLIRHLHIQPSFTIFSYTNPHASQRNSTGFSIPNLNFATMEPVGTDFSSSLTISIVMDEKTLKSLLRIFKLTLSLSTVYSGFEEALPIIREGFQSIPRSINPMSDEYPVYRLMIHFKRTFHWINLFLHKCYYYVFTYIIPKHTKEFEDTLVSLGSIELIINEMRSFLKKLRHDLFMDEKSKTVFTTLLETLCFCNDYLYFLKSSLYKITSSDIKLTPVEIVSIEREISSFLSIFINKLDHMGDCIIKECPQASMNVERKNFYNMILQLLNNGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Z7</accession>
    <name>A0A0N5B4Z7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Z7"/>
    <dbReference type="WBParaSite" id="SPAL_0000114500.1">
        <property type="protein sequence ID" value="SPAL_0000114500.1"/>
        <property type="gene ID" value="SPAL_0000114500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000114500.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9732" checksum="1C03CCBC813133E1" modified="2015-12-09" version="1">MYSTSFNKVVQVIIFMCFISFAVINCEMNSQFSNEFKNAPIRARRQLSVGATGQLGDRLNKEKENDLKETVTKHYKVPSDPYSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B557</accession>
    <name>A0A0N5B557_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B557"/>
    <dbReference type="STRING" id="174720.A0A0N5B557"/>
    <dbReference type="WBParaSite" id="SPAL_0000120400.1">
        <property type="protein sequence ID" value="SPAL_0000120400.1"/>
        <property type="gene ID" value="SPAL_0000120400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000120400.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39455" checksum="C2A86FC11FCB6C5D" modified="2015-12-09" version="1">MPENMTADGSSKTNEILETLVKEAEELRKKLDAERAKLNDVPIQQAAERLEPLSHLSIKQRRLLKGHASKVLCMDWAQDKRHIVSSSQDGKVIVWDGFTTNKEHALTMPTTWVMACAYSPSGQMIACGGLDNKCSVVPLSFEDDILQKKRSVATHTSYMSCCMFLRSDNLVLTGSGDSTCAIWDVESGQMIQNFHGHIGDVFAVDIPKCDTGNVFISGGADRHVLVWDIRTGQCVQSFEGHEADINTVRFHPNGDAFATGSDDATCRLFDLRADRQVAVYEKDSILFPVNGVDFSTSGRILFAGYGDYRIGVWDSLKCIRQSVLYGHENRISCLRTSPDGTSICTASWDCTIRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B606</accession>
    <name>A0A0N5B606_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B606"/>
    <dbReference type="STRING" id="174720.A0A0N5B606"/>
    <dbReference type="WBParaSite" id="SPAL_0000149700.1">
        <property type="protein sequence ID" value="SPAL_0000149700.1"/>
        <property type="gene ID" value="SPAL_0000149700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000149700.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="74712" checksum="91A7238F3C422024" modified="2015-12-09" version="1">MTKLFPIFNCKNNSKEITDHTQKGKQVNLKSKLENERKTTKRKAPGITRKQNDEAEESIIILGDSSDDILLDSCNKESTTNNKKSRNEYWKTKVSEEITIISEIISKDSLKISEDERKITSNKNFTYTKEMDYAPYSKLYHVLQNNSDPDIPLTYKFFFSEKTKVAKKDLILDESMSNNVKNIVNDSFYVGHCPTSEETSKIYHMQMNNAMQSWYTYGAEARAIGRLSNSLLSSALKPDHINDFLNNLNKVLKLRKWMTSWKNKITNPSLFSKKVDRNDDNESDCSKDSIDYMEIPFNPLIITGPSGVGKTSSIKFIASELEFNVISFGCDEKRNSTSLNTKLAGAISNFGMKSSKSTLQNFFQPVVTQSKTSNQKLGLTCIVIEDVDVIFDDDDGFWITIKNFCIDSKIPIILTCTQENNALKELSKFPSFHYRKSVLQFDHISVNGLTDLIRSLIFGSYKYYLNRVYLKQLIKEKKMDIRAILNHLHFILSTGLQPIFDNKSDFISEDISWYKKSYLMNEISDITSNNTITYLPDFSEEYNREIYRSYCESSKDNQRNNIKELFNPIVYADIINNLKNIRFCDNTSRSELASDVIDALKIIDQVFESKIVQSRGQNRRHPFTRLGEMIKHPIIANSLRLKIKYNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Z5</accession>
    <name>A0A0N5B6Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Z5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0000183200.1">
        <property type="protein sequence ID" value="SPAL_0000183200.1"/>
        <property type="gene ID" value="SPAL_0000183200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF373">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000183200.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="38251" checksum="8786FED271406B5D" modified="2015-12-09" version="1">MKKDDHKRIYKIFCYDLSSSFLRVEMVRQSYSLNNSIIDAEKHDKYHFIATLSIFVSGLSIFLLLLAGVAIANNVEKITLDIEQRSAMFKANSESAWIEMMELQGIDSTKFRHEPLFRVKKNIENVNKCNQCIRLTCPSGAPGPVGPPGLDGAPGDPGKIGIAGKDGLDITLLPPPELPCKICPAGPIGGRGQQGERGRPGSAGNSGSPGVPGKPGLDGAPGSPGRPGMKGKDGIPGVKGPPGDTVVSGVGVKGPKGPPGPSGIKGPHGLPGRPSNMPGPTGELGRVGPPGPRGFPGKPGDRGDWGVQGLPGESATYCPSDCGVSKILAPLHVTFPLTDEGDNYDEEVSAPQQVPASNGATDEQGYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8A6</accession>
    <name>A0A0N5B8A6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8A6"/>
    <dbReference type="STRING" id="174720.A0A0N5B8A6"/>
    <dbReference type="WBParaSite" id="SPAL_0000227900.1">
        <property type="protein sequence ID" value="SPAL_0000227900.1"/>
        <property type="gene ID" value="SPAL_0000227900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000227900.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="85676" checksum="23A64208908F8A55" modified="2015-12-09" version="1">MSSKIISEDLPNSLNKRNRIKDDKIVSNNISDNESGNGKCKNSDETDSLSIMSDTITIKKLSNGTSMMDREANEFINETGYLKRNSNDNAYSNSNILDASRLKSMNSGNHKDSNLLFPIPDHSHSSGNWSPNLRSKRNSISIMKEKVIETSKDIGQTFKDVAGRSVRNEVIKFGGSTSAHGLPLLQFDSAKFPAITICNLNAFKKHLAKTVPELQETLQAFKQAVRYSKGASNHLQNDIKLRNKRNSFRYVQYEPVISDCECPVHVIKTKEGELNECLQKDGVPSSNSSTCICNFDRQDDSVWPCYKESTWRKDFCPECNDIGYCNLPDTNGTKKLPCLCQNNVGYCLLQPDRIKKVWEIKGTAVPSEDSPYRDDFLKQLKELGYENTTDEVAITTKTKEKLVLTMAGLPVQRRIALGYGKSEFIKMCSFNGNQCDIVKDFKLHVDPAFGNCYTFNYNQNKSKIFYSSRAGPSYGLRMMLYVNSSDYLPTTEATGVRIAIHDQSVWPFPDTFGYSAPTGAISSFGLSLRKFRRLGPPYGDCVEANGTLPNDYIFKNNAYEPEGCYRSCYQTRIIQKCNCGDPRYPVSNNRTKYCDILDVTERQCLLHEGIKFTKDNDCKCRHPCQQNVWTTTYSAAKWPSGSFKVGSCNKSLEDCINHYSTHAAMVEIYYEQMSYEKLQESESYLFVNLISDIGGQAGLWLGASVITICEITFFLLRLLTVYCRKPMVSAKNESEIIGRKSKWSPVDINLYGNSNNLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8C4</accession>
    <name>A0A0N5B8C4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8C4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8C4"/>
    <dbReference type="WBParaSite" id="SPAL_0000229700.1">
        <property type="protein sequence ID" value="SPAL_0000229700.1"/>
        <property type="gene ID" value="SPAL_0000229700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000229700.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="82216" checksum="B0D19B686BC02EF5" modified="2015-12-09" version="1">MRNVYRARFSALTEKDIKFAMNNLVRPNMNESLSVDARQELDLRIGCAFTRFQTKYFNNKYGDLNSACISFGPCQTPTLGFCVKRMDEIVSFKPVPYWQIQCSLKDSNGEEFKVQWSKGSIYDREVINFFFNRIKNENTATCSDITTSNGMKEPPQALNTVELLRIASKNMGIGPQDTMVIAEHLYTHGYISYPRTETTQYPSQFDFKSILGSLSNTNEFGRYAQKVLNEGIRRPKRGEDKGDHPPITPMKEDNGKLSGNQRRIYEYICQHFIGSLMKPCKYKTKNLIFNICEEVFTYSTKSVEDPGYTEIMTWQSVSELKTLNNIEKESVLDVKSLGIVEKQTTAPEYLTESELITQMEKYGIGTDASIPVHIANIVQRNYVSIESGRKLVPTKLGVSLVHGYWKIDPELVLPSMRSEVEEQLNLIAKGQANYQSVKEHALNMFKMKFIYFTENIRGMDELFEDSFTTLDACGKPFSRCGKCLRFMKLVDSKPQRLHCNCCNESYNIPISKTGQIKQYSGDKRCPIDQFEILYFSENVGQTIKGYPFCPNCFNNPPFEDMNKKDGCNKCPNVSCEFSSISCGLTNCLNPDCGGILYYDKLTKPKYKISCNLCPITIELFKGANNLKINDKECLICGSNTIMVDYKESSPLPDGALKFNGCLFCSSEVYNNSTLVRVKDYTRSIENEKKFQYSRGNRGRGRGGKRGGHSRGKSSRGSYVKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9D1</accession>
    <name>A0A0N5B9D1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9D1"/>
    <dbReference type="STRING" id="174720.A0A0N5B9D1"/>
    <dbReference type="WBParaSite" id="SPAL_0000264700.1">
        <property type="protein sequence ID" value="SPAL_0000264700.1"/>
        <property type="gene ID" value="SPAL_0000264700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF54">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894135" description="Delta-like protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="15">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000264700.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50305" checksum="C5BE73303BCE4D64" modified="2015-12-09" version="1">MFSIVLLYLLVCLSIVSPNGVFEVKFTPLVLDEEKLFNITVCLKEYQTIVNDDDICRYGSRNFQILPSINKTSIISLPFTQIWPGSHSLIIKFNHDETFKISHLRSGKTSWLHVTSNKYFNVHYRIGCSPNYYGNECSRFCNPPIHENEHFACTDEGYIECLPGWSGKKCDKPICLKGCGENGKCIGPDKCLCPNSQIQETCQECTALPGCQNGYCSKNNECTCEEGWGGKLCNIKLSPCQIKNICRNGGICKLEKDGTSSCECQKGYFGKYCQKKRKTCNEHTCLNDGTCYINNDGIPKCHCINNFIGTYCQIKLIRSQTMNIKSRGGHLEFMSYTDINMILVIIASLLSIVIIILVLILLFRIRPKSIHDGKNYKKEHIHTPKFENEYTLEPQHIQFNEMLDFSIHTPQLETAAKEKSSRNSSTTCLKPFNNIYYTISYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAG6</accession>
    <name>A0A0N5BAG6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BAG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000303600.1">
        <property type="protein sequence ID" value="SPAL_0000303600.1"/>
        <property type="gene ID" value="SPAL_0000303600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000004">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000303600.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36135" checksum="A538C7116D316575" modified="2015-12-09" version="1">MVGIETQNRIIVELLLQRFSDIKSGQEPKKICHDFCDFDGVVFNLVNENGNRKLILLSIHLKYFKELKEYGAMDVLKRIYGNYLLPKPLDNYDVTLRYDLDTIPDDYQDIITNASLLKRNCFAAVFEKYFRLQQSGEIIKEQAVIHYRDDETLYVEAKQDRVTVIIATQFADPEDAIYGNIFLQEYVEGRKINKTSPQIIFSNGKPPAEMANITAPLNNDECVFYVAFVLEKRHTAPNVMENTIDLIHIFRDDLHYHIKCSRRYVHSRMVKKADEFVKIIERSRIETNNINNKNNSQNQVKKGLVRRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBH2</accession>
    <name>A0A0N5BBH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBH2"/>
    <dbReference type="STRING" id="174720.A0A0N5BBH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000338100.1">
        <property type="protein sequence ID" value="SPAL_0000338100.1"/>
        <property type="gene ID" value="SPAL_0000338100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF37">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="114"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000338100.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54721" checksum="A7B097098A725566" modified="2015-12-09" version="1">MTTTARENFTCYQLSQSNSYSSFNRCSPEFDKSLCWYNVTYGEIGYRICPFTFCKAIPGCESIAETYRVTKMCHENGTWGTTVYDKCIDILQHHKECIAGFCRQCPENNIREITINVSLILSTVSVAGLLIALVLFNIFDSIQCRRLSIHKNLAIAFIMRFTMYSIWTIANSNNVFRDCSHFNPQHRLELDWLCKMMLWLVIYFQVASVIWMLIEGLYLYSRFTVLAMRSFEPSYKWILLSGWGIPFIAVLTWSIVHAQYSMMNPKSYCWLPYAKGNHLWIIGGTMSFALLANVLLLLLIVIILVQKLRSENAAESAKIWKTIKATLLLVPLLGVSNILLFYEPDQQDGPYMLYSAILQNSQGIFISILYCFLNSEIQNAVKRQINKFSFRCFKRENFGTERTYVPDVSMATRRLGTPMEELSTSKDKNCHVNSLTPSQVSQSILNNVSSNNIEKIDNTSSSDSENTVTKNKITDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBS5</accession>
    <name>A0A0N5BBS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">H15 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBS5"/>
    <dbReference type="STRING" id="174720.A0A0N5BBS5"/>
    <dbReference type="WBParaSite" id="SPAL_0000348200.1">
        <property type="protein sequence ID" value="SPAL_0000348200.1"/>
        <property type="gene ID" value="SPAL_0000348200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="7">
        <location>
            <begin position="55"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000348200.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18569" checksum="01930F80508BA2C3" modified="2015-12-09" version="1">MSLEDMAGLTTDETNELENTLDVFMDIQDCSFPSLDDSHSSTEGLSVARGTKRTPIPSYMDMVSKAIGVLGGKKGSSRLAIFNFIRNNYDLGNRSVKAVNNQIKRTLKKGVDTGVFKQVSGTGANGSFVIADNGPNKSESRKRKQSTTEKESSKDGSQVKRARGTRGAAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBY4</accession>
    <name>A0A0N5BBY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000353400.1">
        <property type="protein sequence ID" value="SPAL_0000353400.1"/>
        <property type="gene ID" value="SPAL_0000353400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21525">
        <property type="entry name" value="Nlp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000353400.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9883" checksum="BB3BB191AB34E3AF" modified="2015-12-09" version="1">MAIDLKQEFQLFDLLGPVVCAGIFALFLFLFSFFILNYCCVLKDDDITKFEEWGYKHNLGSKLGPHTKVYIDNCVKNKRVGLINSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCF3</accession>
    <name>A0A0N5BCF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000370200.1">
        <property type="protein sequence ID" value="SPAL_0000370200.1"/>
        <property type="gene ID" value="SPAL_0000370200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894062" evidence="1">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000370200.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23765" checksum="EEE3F155589E0E76" modified="2015-12-09" version="1">MNFIILLFFFIPIIHSCGNFNCPKFTNHARITFKIHPTLALTYNTVPGKRRQHQWFSFEQLQKRLNQIPREVINDFRVQHRATPAQAREKVRIVNRLRDILNVTVINNECMFDCDYKQSIAPAGTHFISGGKLRRRLVDTICLNGEIVQEKSEPVVVQLVYDISVAITGGRTFCQTHWRGVANAIQKKMERGNRGTFIGQSVIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDM4</accession>
    <name>A0A0N5BDM4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDM4"/>
    <dbReference type="STRING" id="174720.A0A0N5BDM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000410700.1">
        <property type="protein sequence ID" value="SPAL_0000410700.1"/>
        <property type="gene ID" value="SPAL_0000410700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000410700.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="30586" checksum="981B7488119BCB6C" modified="2015-12-09" version="1">MRKSIYPKKYFNLTFSYLPNADIQLTRLNKNWKFVNITNEEKTEIDKYLSIIFDKKKKKILWLVSNCRTPSGREHAIKHLKKYIKISQFGKCTGSRIYLNYQETEKLFNDYYFYIASENSDCKYYLTEKIFSRLTFTSIPIVNVRRFYEKYAPKNSFIAMDDFKSPKQLARYLKFLIRRKSKYLEFFNYKKLGWKSESVSTGRCHLCREIIQFIESKKRKVYYDIENWLKKSTFCLHDNYVPKLWKLKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDP2</accession>
    <name>A0A0N5BDP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">APH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDP2"/>
    <dbReference type="STRING" id="174720.A0A0N5BDP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000412500.1">
        <property type="protein sequence ID" value="SPAL_0000412500.1"/>
        <property type="gene ID" value="SPAL_0000412500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011945">
        <property type="entry name" value="HAD-SF_ppase_IA/epoxid_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02247">
        <property type="entry name" value="HAD-1A3-hyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000412500.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55669" checksum="BAE87E4A2090990E" modified="2015-12-09" version="1">MSSVRCVLFDLGGVLVPSPYQEWTKKENNSNLKGDDVLKTLLSPNVIESFHNLEKGLITTEDFDPIFTYFYNIQNPSRQINGIAHIFGVKDCHPVKINDKFRTVVQILKAKGYKVGILTNNFYYDRSRQSSTLPIISSDLQLFDFIFESCKLGMRKPEKKIYEYVLNEMKLKGNEVIFIDDIGKNLKSSKELTGMITIKCENIDTTIQKLEDLLKTNLKTFIPGVVSIEGNNTLNPSILLQYLQNLFKTNEGSLDIMKFSHGQSNPTYYLRFGDKELVLRKKPSGKLLPKAHMIEREYKILSLLQGKLPLPKTYVYEENLLDSPFYLMEYVRGRIFIDPNLPGLSPKDRKEVYEEMIRILKKIHNINIDINGLEDFGSREKNYMIRILERWKKNYELANGCKDDNHEVQILLKWIESNIPPQNRVTLVHSDFRLDNLIFHPTENKVIAILDWEMNTIRDPLAYLATCAFAYYYSTQITGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDQ2</accession>
    <name>A0A0N5BDQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA_14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000413500.1">
        <property type="protein sequence ID" value="SPAL_0000413500.1"/>
        <property type="gene ID" value="SPAL_0000413500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000413500.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20427" checksum="A65A120E865A5C54" modified="2015-12-09" version="1">MEIQNVIEKDFDFYGVSLGYQSQVNISIFGLADKTKIITWGVKNSPRAHDDFNHMKAFFKMSRAVYESLHNSQFFAKKEVIFPETSDYLSQFYQWQNDLRQEEVVKKYIGPDRQALVKDFYRSCEYANYSICSENEFLKFPIAKLLLDEVDLLRGTMESNVLRIGQIMTNSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEM2</accession>
    <name>A0A0N5BEM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEM2"/>
    <dbReference type="WBParaSite" id="SPAL_0000444600.1">
        <property type="protein sequence ID" value="SPAL_0000444600.1"/>
        <property type="gene ID" value="SPAL_0000444600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894162" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000444600.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11303" checksum="57FA93668DA0192F" modified="2015-12-09" version="1">MSLYKGLLVFIASLIFFFSTDVMGMTNSKLGQDDYVASFYSDAETPSLIPIPEQLIKRRILKNGENNYLLRFGRSNERPGDLERFLQMDVQIPLFRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFE9</accession>
    <name>A0A0N5BFE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFE9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000471500.1">
        <property type="protein sequence ID" value="SPAL_0000471500.1"/>
        <property type="gene ID" value="SPAL_0000471500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF5">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000471500.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58486" checksum="2A6F1D45D053A3CB" modified="2015-12-09" version="1">MCQSFQINDISQLMTCMDIFLVVYIIIIFCQLFSCKQNICKEDISFCLNNYKIDNEEVRGKCEAYFRTDCACPKKADPSCFDFVDNCLDYDEYCREKNYRRYMRKICPYTCGFCDRADPPGIECFDKFDKCFEKRHRCWYEEYSFLVTRRCSYTCGICQNTTRSVFDCYDKYHRCSELQNECTSPIYKDYMSVMCTGTCGHCDEDVTTTLLSTTEESSTLENIITTTKKKTTTTTISIPVIVPIPPEKLSTSTTTTTTTSVKTEKPKINKKTKNPKSLATTIITSTISTSTSTTTSTSTTTTTSVKTEKPKINKKTKNPKSLPTTIIASTTTTSTSTISTSTSITSTTTLTSTTSVKTEKPKINKNTKNPKSLPTTIITSTTTTSTSTTTATKSITTTTTPTTTTSVKTEKPKINKNTKTPKSLPTTIITSTITTSTSTTTITKSTTTTTRSTTRITTKSGILRRTPTITRKILIITTSKITTRKMPTTTIRKMPTTTIRKIPTTTTLPRRFRLGKRIYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGD4</accession>
    <name>A0A0N5BGD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGD4"/>
    <dbReference type="STRING" id="174720.A0A0N5BGD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000504100.1">
        <property type="protein sequence ID" value="SPAL_0000504100.1"/>
        <property type="gene ID" value="SPAL_0000504100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF130">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000504100.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59610" checksum="FA3C929C6CCC59E6" modified="2015-12-09" version="1">MILFPIILTLLFIYILTKAKSIFKWVMVKRRKHELGNKIPGPKPIPFFGNALSFPKDTLKTIDYITEEIDKVREKKEPFARFWIGDKLLVVPLNGAAAKYVIDTELDKGLDYELMKEWLNEGLVTSSGEKWKSRRKLITPSFHFSMLKNYFSVFNKESKIFLECLQKYVNTNKKVNIIDYAKRVTLDIIGETAMGTKMNSQKNLNDNYIENVEKINRNLAIYTRNPLYLYKPIWYLFGEGFSQDKCLKVLKDFTSNIIKNRWIKYQEDVMNNNTKGDESDKKKEYDFLRTLLDHRAQNKMTDQDVLDEVQTFSFAGHDTTATAFAFLMWALATHPDIQEHLYDEICDVYEKEERDVIPDDLKKLEYLDRVVKESLRRHPTIPIVLRSTSKEIDILGYTLPKDTDFMVSIYHIHLNPETYPNPYKFDPDRFLPENCATRDPYDFIPFSAGPRNCIGQKFGLFELKTLVIWALRRYKFYTNLPYDYIKILPEVVIHNDKDYPILITTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHC2</accession>
    <name>A0A0N5BHC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000536500.1">
        <property type="protein sequence ID" value="SPAL_0000536500.1"/>
        <property type="gene ID" value="SPAL_0000536500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000536500.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16427" checksum="FBFD0D8F7915269A" modified="2015-12-09" version="1">MMTLNLATINVRGIKAYPIRNNLMKELCHNEIDITIITETKGKEGISEKCENSLISCGKSSEKCIGGVEFAISNENIIKHIKVIEHINFRLSYMIVNIDKRKSLGIIAVYAPTNCYDDIDKDEFYLQLHSLYAKVRQMSTVTILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJM9</accession>
    <name>A0A0N5BJM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000615200.1">
        <property type="protein sequence ID" value="SPAL_0000615200.1"/>
        <property type="gene ID" value="SPAL_0000615200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000615200.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25125" checksum="B6245769AD91ABD3" modified="2015-12-09" version="1">MPTDNKFVELFSPKNLFKKKAETNIDLIESTIKEHHDIWKNEQKSFKESSLEEKIELLQKQQSSLLNLLQTHNIPTELHNNYPLPIFYNSFKGILKNKILVDKKDDNNVTIITLPDLSTKSDVTSMLPNTSHQEKLEIMENINKNIGNVIQINDYPKQQAVNDNNTLENTKTISINNDEESGVSKEETSKINKLIQKFDDYVDDKVIPYCYGYDDCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJT0</accession>
    <name>A0A0N5BJT0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BJT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000619900.1">
        <property type="protein sequence ID" value="SPAL_0000619900.1"/>
        <property type="gene ID" value="SPAL_0000619900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000619900.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11569" checksum="CF63C0EBA49F148A" modified="2015-12-09" version="1">XNTSDENYNPIDRPCDAIFEEDRENAGCYNRLDEIDNEIIVTGAVDVPKCYETWRDANFHPTLHNAIMKSGYTKPKRTQAFAILIIADGFDLICQSEAASGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKA0</accession>
    <name>A0A0N5BKA0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKA0"/>
    <dbReference type="STRING" id="174720.A0A0N5BKA0"/>
    <dbReference type="WBParaSite" id="SPAL_0000636000.1">
        <property type="protein sequence ID" value="SPAL_0000636000.1"/>
        <property type="gene ID" value="SPAL_0000636000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000636000.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15650" checksum="EEDF91BCC19D2F45" modified="2015-12-09" version="1">MKFNPHVSSSARKSRARHFNAPSHVRRVIMSAPLSKELREKYGVRSCPIRVDDEVTVATGRAKGNSGRVVKCYRKKFVIHIDKVQREKANGTTVNIGIHPSNVIITKLKLNDDRRKTLERKAEGRKAVLGELKGKHSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKK8</accession>
    <name>A0A0N5BKK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKK8"/>
    <dbReference type="STRING" id="174720.A0A0N5BKK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000646400.1">
        <property type="protein sequence ID" value="SPAL_0000646400.1"/>
        <property type="gene ID" value="SPAL_0000646400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022248195" evidence="17">
        <location>
            <begin position="25"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="28"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="248"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000646400.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="63017" checksum="5EEF711F45D24269" modified="2015-12-09" version="1">MVNVKCSQLIILVTAASLANYVDSSTGESDLYRDLLANYTSLVRPVKSNGEKLKVSMKVFLQQIVNLDEKNQVIEINAWLKYKWEDYRLKWNPAKYEGITSIRLPSTENLIWTPDILLYNSADKSFDSTFKSNLVVYYDGEINWIPPGIFRASCVIKIHWYPFDYQSCFLKFGSWTYHGYALDLQIDSEPGEEPGMDLSTYIPSSEWVLESAPAVRSEVFFSCCPEPYPTIKFYINIRRRTLYYIFNLIIPSSLIGLMTLLGFCLPAHDMSEKIGFETTILLSVSFFLTVVSQTIPETSDGVPLLGLFFSTITLIVTISTTFTILVLNFRYRQPCNHKMSRTFKKIFLEWLPWLLMMRRPEHKILKSRTIKLKDPNQFTDECLQCLGKQDKDDKVIKETMVNGCDGIISTVSTSLSEALIKIPVEKLNLDRKVGDGIFPEKHIKSSRKIQIKQYEKFVTKCVEMVKDGESDESTSHALAIINYYTRIQHHLEYIKKQKQRDEKVDDLTEDYKFASMALDRLCMIIFSIFIFIAIIIIFSSPSYLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL45</accession>
    <name>A0A0N5BL45_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL45"/>
    <dbReference type="WBParaSite" id="SPAL_0000664600.1">
        <property type="protein sequence ID" value="SPAL_0000664600.1"/>
        <property type="gene ID" value="SPAL_0000664600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="132"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000664600.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31626" checksum="359481DAD1049E9E" modified="2015-12-09" version="1">MIQNDIPTKQFINHDSINAYASENIEIKYVEKRKSNGKRSKTIQKKVVTKKTTKRMTPKKPLGKTTKKPLGNTTKKPLVKKTTTRTSTSRKTQSTRTTPRKITPKTTTTKKPPSRITTSKSTTTSKPVKYKEYIDEIVKEINNIRKYYKTPELEVNSNLAREAQKLADKLLKTKKWEDYKNNTFGVIIYFTPSIEDQYDPIIRWFYGFEKIDYKNLEKTIPPALSQITWVSSKKIGCAISEENPENGALLLCLFSPKGNIPGEYNKNIRIKPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLX7</accession>
    <name>A0A0N5BLX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLX7"/>
    <dbReference type="WBParaSite" id="SPAL_0000692300.1">
        <property type="protein sequence ID" value="SPAL_0000692300.1"/>
        <property type="gene ID" value="SPAL_0000692300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000692300.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35252" checksum="D24E44841488AA6B" modified="2015-12-09" version="1">MAIISAIVPGYLKLHIYVFDEYMVFYLEPLSHPPSNDFTHTSLIGLLIFILYFNITITTGLIAARFFIVCTSSGFKKNSLIKVLSLCITLTIIQAFGITFPFSEHVPSDVIVNAIKNHKIKERQLTESTVALGCKVYDSKFLPLFIIVPIYFTVNYLFIVYFVKKYKLYIKRHQEIISKQCQNKNKEFMTILIIQAFTPVCLTGGPVVLIVILIIIQRVYIISSCINNIVHIVSFIPSVNGFLFAILLPSNRKLILSALKKIMDTIMCKKSNQINNITASNILKKHSFKICDSKTSLQQKRTHPQSSVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMJ5</accession>
    <name>A0A0N5BMJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BMJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000713400.1">
        <property type="protein sequence ID" value="SPAL_0000713400.1"/>
        <property type="gene ID" value="SPAL_0000713400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000713400.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="17867" checksum="BE18C4640A2593F0" modified="2015-12-09" version="1">XAVVCTACGANGHIARDCKNPLPGGVVVDEEYQALMNQLNEANVDPSTYVMYAQQGLVTPTAPATASPGQFPPAGGSLATNYPGYTPNQNQQIAPGFGFVQNNPQNATAATYPQPPIDMSMFYAPPPPPPPSSGSVMMGYGDSTGGLDSIESMKQAALAYAARQTAANDDEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMK6</accession>
    <name>A0A0N5BMK6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMK6"/>
    <dbReference type="WBParaSite" id="SPAL_0000714425.1">
        <property type="protein sequence ID" value="SPAL_0000714425.1"/>
        <property type="gene ID" value="SPAL_0000714425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894623" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000714425.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13990" checksum="7ABC9BFF26924205" modified="2015-12-09" version="1">MKYFFLVHILFFALFIVILSQTIQYGNWKNLNPNSPIVRKWANEGVSLYGAERNKTFILVRVLRAQSRNGFSAPNITVKRHRVYCTARNAMCPRLGGCKRSLRTIIVNYLNGTRTVNVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMT0</accession>
    <name>A0A0N5BMT0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000721500.1">
        <property type="protein sequence ID" value="SPAL_0000721500.1"/>
        <property type="gene ID" value="SPAL_0000721500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000721500.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="53666" checksum="224EB331F351B97A" modified="2015-12-09" version="1">MLKFYISLFLCIVFYCYGDCYKILVYNPLFVSSHSTFMVKIANLLSEAGHDVTILQVMMNPKIDDSGVKGPKIVKPSNRNPDIESKSNLLKGLDEESWSGKHDNPLKMVNQNKELLSWITSACEHTIRDPKLTVKMREENFDLAIIEIFVPCGLGVAKYYNVRNTVTVSSGPYFDSTFAALGLTVPVSQLSTSFAPLPQKMNILERVFNFVTYLGIKTIFNHGISVGNDIFERIYPEGQIDLDKLFAETAYYIVNSDPLTNYGMPSTPKFLQLGGFLSPNSKPLSGEFNEILNRRKKNVLVSFGSIAKSTKMTDNMRNNLARLFKEHPDVTFIWKYEEDRPEIFKGIKLGRYISKFDFDGNYDKLKEVFDDLMNNKIYSETAKRTSLMIANRPYNPRDLFIKYIEFAAQFGRIDHFTIPNSDLPLWKYLYLDFISLLIGVILMVVFIVKKTINVVKKSICKGKKNHKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNT4</accession>
    <name>A0A0N5BNT4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNT4"/>
    <dbReference type="STRING" id="174720.A0A0N5BNT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000756200.1">
        <property type="protein sequence ID" value="SPAL_0000756200.1"/>
        <property type="gene ID" value="SPAL_0000756200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000756200.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25610" checksum="5E4667FA273713ED" modified="2015-12-09" version="1">MSSSEEVSWVTWFCGLRGNDFFCEVDEDYIQDRFNLTGLSEQVPHFRNAMDMILDLEPDDEYDEVHSDVVEQAAEMLYGLIHARYILTNRGIQLMLEKYRNEEFGNCPRVYCEGQATLPIGLSDVCGESMVKLYCPKCCDIFNPRSSKYSHTDGAYFGTGFPHMLFFVHPELRPKTPTKYYIPRLYGFKVHSSVYAHTPNNSQKRMLKEEESKEEQSTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNX7</accession>
    <name>A0A0N5BNX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNX7"/>
    <dbReference type="STRING" id="174720.A0A0N5BNX7"/>
    <dbReference type="WBParaSite" id="SPAL_0000760600.1">
        <property type="protein sequence ID" value="SPAL_0000760600.1"/>
        <property type="gene ID" value="SPAL_0000760600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000760600.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="34083" checksum="0DCC036659EB3406" modified="2015-12-09" version="1">MEGKKQLHCDNEISNGNNLYFNIGLLSIFISSFVIFFLLLSIPSLYNKVTIEGDRVALLSMTYKHNSNRIWGLILSLPTKKFAFALTFSRNKRDSWSFDVCKACASLICPSGSPGVTGEPGIDAAPGEPGKTGEPGNDGMDIALSSFPETPCQICPSGPTGSRGLQGERGAPGSPGPIGDPGEAGLPGLQGQYGKRGLPGPQGEKGPVGNRGPDGDISISGIGIKGPKGPPGNHGPKGNIGIPGKPSNIPGNPGLPGNMGIQGIQGREGRIGDTGPEGIVGQPGESEARYCPSDCGVSQILAPEQNFIDINVPNDKENKLYIQSLFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPK9</accession>
    <name>A0A0N5BPK9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPK9"/>
    <dbReference type="STRING" id="174720.A0A0N5BPK9"/>
    <dbReference type="WBParaSite" id="SPAL_0000783300.1">
        <property type="protein sequence ID" value="SPAL_0000783300.1"/>
        <property type="gene ID" value="SPAL_0000783300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="8">
        <location>
            <begin position="237"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000783300.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49010" checksum="BD121E12846B7946" modified="2015-12-09" version="1">MDAKKLGEALKKMKELGIDPKQIIAATEGGGIKDIEEAKNHTYEFWKTQPVPGFDEVVTENTFILPDEHYEKSVRLEPYSLPKGFEWSDIDINSNEELNEVYTLLNENYVEDDDCMFRFDYGPAFLRWALTPPGWLKTWHCGVRATSSKKLLAFISAIPVVIKTYDKKTQMVEINFLCVHKKLRSKRVAPVLIREITRRVHCQKIYQACFTAGIIIPKPIAACRYWHRSLNPKKLIDVGFSHLPRNSTIQRQMKLYKLPDKPKTANIKPMEEKHVPSAFKLLSEYLEKFDLAPVLTEAEFKHFLTPVENVIYCYVVEDKEGNVTDLCSFYNLPSTVVSHPKHKEIKAAYSFYNVATTVPYTQLMNDALIFAAANNFDVFNALNVMDNSEEILKELKFGIGDGNLHYYLYNWKCPEMPSCKVGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPX9</accession>
    <name>A0A0N5BPX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000795500.1">
        <property type="protein sequence ID" value="SPAL_0000795500.1"/>
        <property type="gene ID" value="SPAL_0000795500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052861">
        <property type="entry name" value="BPTI/Kunitz_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248:SF6">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248">
        <property type="entry name" value="PROTEIN CBG06772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000795500.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11318" checksum="2F5139E2EFD7BB23" modified="2015-12-09" version="1">MLMTVSLGAIIPKPPIFFDSNTYPSICYLPPDSALCMPTDQEGKVIDEITEDLPIKFYFDIATEQCYPFGAQNCGGNENNFGSEEECQAICKINPKDNVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPY3</accession>
    <name>A0A0N5BPY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000795900.1">
        <property type="protein sequence ID" value="SPAL_0000795900.1"/>
        <property type="gene ID" value="SPAL_0000795900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000795900.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20262" checksum="20AD5CA98D21763F" modified="2015-12-09" version="1">MLVNTQNLGNLTRQNDLSKIFDDYCKLHNIKLAPNRYTTIVGVNKKFNLHLDIAGCFSKYFKRINSPDTVHYIKRNDITDRAIGKVIEWIYTGNTTIAPFDFEQINYLCNLWEIEKLQVILNAFKNVKSGSNETSYTRERNDTQNSSIRGERKKNILPICKADGTGVKAQLPFIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ80</accession>
    <name>A0A0N5BQ80_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ80"/>
    <dbReference type="WBParaSite" id="SPAL_0000804900.1">
        <property type="protein sequence ID" value="SPAL_0000804900.1"/>
        <property type="gene ID" value="SPAL_0000804900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="562"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000804900.1"/>
        </source>
    </evidence>
    <sequence length="1515" mass="175314" checksum="04CB1F1465A63F15" modified="2015-12-09" version="1">XLNNLRNDMVEKLDALTNQIALLLKSKNINNNEQHSPPQNLNMSTSSSFTDVQLQVLQALNSNNLIKPFDGTNESINFKTWFSNLERYFKLNGTISSEYFDYLLLKLDGEPLEIASQYDGNYFQVKKQLILLFDSNKSCISAERELDSLTRQIDRIQDLDSNASKIKFLCRIVYQGKSGEERLKVQAKKLWSLLRPSIKKVTKLPMRYNDFDWDLFILDIKQSFEIDSAEYRERRFPNRNLKLPSDSHNKEKRCLNLGCKFPYNHDTSNCKMQKILKDHKSLPKNNLVMSDSPNNLLTSVEKECNTVFDKNEYLESSQDDSDSDASLSDAPGLIYKSGKISNISVVIAIDSGSTFTSISDNLQYLLKMSDKKGSEVPIKIIEGITAVKRAKEKRFLTIEDNSIYLKHPLIFNSHYHNFDILLGRDMLKKYGAIVDHTDGAINCEFSPTTHDDITFNDLKVFQYGININSNEESKTYALCAESVIVDQDKQKYLDEFIAASDKSLREKFPSVFIVNDSQIVPTMVAEEQHFNFTEQNKNYETYGSSYHNQSIALQLAKTWEDAGIIEEGEPDNGITHPVKLIDKQKDSSDDNKNVDITSRYRLVCDFRCINEFTHKHCEISMNITNSILTNRPFVFCSKLDFKTAYGQIKLHSSNTRSFNITIGHKKFNYLTLPQGARNSATLFKIVMMNLFQDLFEQQHLQWYHDDMLIMTHADSQSPLTIDDEIRKAQEHCDLLELVFQRMESKNVKVSQIKSQLFQKSVSYLGFTLTRTGWRPSIQSVNRILNRGRPDSRESLRRFLYASNYFFICIPNFSVIASSLYDLINTKSKKKFVMQTHHLDAYHKIARSLCDVNHKLYFGDPNADYIIRVDASSTEIGGSISQNLFDAETNTIREVPLGFVSFRLPKVVRRRSSTYLELKEIASVLEYYKFLLENCPGKIRILIDHKPLEKLRYTASMSKHVELLSHIDKFNCIFEYSPGKLHFMPDWLSRIENEKLLHDDESGDDEKGYDDSNEQFNSLTCLLEKDNEILIKRKVGKPKKGESSLTKQCHEKVNVTNKEKEHSDDELNIVELNEKNDMSNTEKNDDDNDIHITELNKKEKSSLYKILRSNILFSFDELKMEQEKDDNFQRAVKNRNFLNYDVRVNDNDIIQICKTNLEKGEACDDKNWKTLIPLSLAEKVIKMAHSQGHYSFIKTLSAINYFCYIPQPGKMIKKILNNCNTCLIRKSGHHHQPSNKTIDLSCYPFDRLSMDLITSRTIDQICHHRYILVVCDECTKYVWVLPLLSKEGSEIIDTLIKNIFTKGALPSVIRTDGDGQFRGSHFTDAMKELDVKLELSTAYDSNSNAIVENKIKSVNKVIHSLTEDYPTTSFCQLLDLVSHFINNSRVIGMQMTPVEMMFGISPRTTLSNILDHNSILKYIDRSDNLNEWLNSITMIRRILNDQYIQYRQNVNNKKKEKYDTFEVRDTFYFRRSREHKFDKNYTPHVVLKNLRTKVLYKSGNKSLETSKAKIKKLHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR95</accession>
    <name>A0A0N5BR95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">B-box type zinc finger protein ncl-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR95"/>
    <dbReference type="STRING" id="174720.A0A0N5BR95"/>
    <dbReference type="WBParaSite" id="SPAL_0000839800.1">
        <property type="protein sequence ID" value="SPAL_0000839800.1"/>
        <property type="gene ID" value="SPAL_0000839800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000107">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="661"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="707"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="749"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="792"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000839800.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="97807" checksum="D547B0A30CF77661" modified="2015-12-09" version="1">MSESDSLACSAGSDSADPFGALLASCNGGFRGMNLQPYSNGMCTLGQTEQLEITQSQSALQDQNIKCGICDETYREPKVLACFHSFCKPCLELKVSERLDNILCPTCGQETQISPSLGVDGLLTDFGALNVAEQYRRMNGTTNDLFLFGSPSSTSSSPPLSDSPGDHGFPIPQSVACTGCKSGERASAFCKDCVNFLCTACTQAHQYMHIFNGHRVEEIGTSKSTSPTGFEQINQCRCLEHKHQLLLLFCLTCNLAICHDCTIDHPQPHHDVQTIENVAANQIESMEDLILRARAKQQEVHKMFMITDANQNKLSESFQKAQNIINDNACKIMQLIQEIRSVVLTDLENAFSYKQLQLTLVDKENQKMVRKIAQTIDFTRRLLKNCSPAQIMVFKPLLDTRLQGFLNFNSDSNNVLQTACEIDYSPLNFSNARQAIINLMGSIHVPSDWSTPVVQNNNTSSVTNNLIPQQASSTPITAVFRPGSRNVRSPNNGMITMNGYNNSNSNVHGSGGRNNEFGSNNSLAAYSELGPASLPTLNSSFLNSNNHQYNNFPSSFPYEKWSTNIDSVMPSADKSDFDAGINTSRDMTLLGHPSCNSPSFPPRSQVKRLKMSYHCKFGEFGVMEGQFTEPSGVAVNAQNQIIVADTNNHRIQVFDKDGVFKFQFGECGKRDGQLLYPNRVAVNRLTGDFIVTERSPTHQIQIYNHSGQFLRKFGANILQHPRGVCVDNAGRIIVVECKVMRVIIFDMYGNIIQKFSCSRYLEFPNGVCATDSGEIMISDNRAHCIKVFNYEGTYLRQIGGEGITNYPIGVGINNNGEVIVADNHNNFNLTVFTRQGELLHALESKVKHAQCFDVALVEDGSVVLASKDYRLYLYRYQQCGTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRD3</accession>
    <name>A0A0N5BRD3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRD3"/>
    <dbReference type="STRING" id="174720.A0A0N5BRD3"/>
    <dbReference type="WBParaSite" id="SPAL_0000843400.1">
        <property type="protein sequence ID" value="SPAL_0000843400.1"/>
        <property type="gene ID" value="SPAL_0000843400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000843400.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11846" checksum="2A56297D21C525D9" modified="2015-12-09" version="1">MLRRLFRRHTLQVMFCLTNIYRTKESKTVEVFSDSPVSNKDILGITSNIHSIESMTDKLFEYSEDCHEEIPDKIEPNKEIKVEESTKNIRDFLIHNDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRI1</accession>
    <name>A0A0N5BRI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000848000.1">
        <property type="protein sequence ID" value="SPAL_0000848000.1"/>
        <property type="gene ID" value="SPAL_0000848000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894751" evidence="2">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000848000.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10056" checksum="B8B644CBAAAF3472" modified="2015-12-09" version="1">MYFTSFNRVAQIMILMCFISFAVINCEENFEFLNQFKNAPLRAKRSQLSINAGADVAEKLLRYRENEAKDSHTKHSPGKLGSGFDYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRN4</accession>
    <name>A0A0N5BRN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRN4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000853000.1">
        <property type="protein sequence ID" value="SPAL_0000853000.1"/>
        <property type="gene ID" value="SPAL_0000853000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000853000.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32336" checksum="FC6E80E70E2400B1" modified="2015-12-09" version="1">MNSFIRHLLVLFLILLTFSILYIMMVNVIDDIYFDSYGNINNVDTTTDNLVNNKLYPYQIAIIMVIANGSEQNYEQAIETVKCYSWHYNYTFVIIRQENVIEFMYNCYHFDFMFLRHCIIANYAEKYKNEIKYVVFIDSDIGVVSPMHKLENYLPKEEEDILFYDRIFNSEIAAGSYIIRNTLLARSFLKFFADYEYKIPENSDGSDNVALQAVFVDFMGTVEYRKQYLQCMKIYDYAVGYAQSMLFVSCMRYILSLMDETPNDIDYHGRNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRU9</accession>
    <name>A0A0N5BRU9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3072 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRU9"/>
    <dbReference type="WBParaSite" id="SPAL_0000859400.1">
        <property type="protein sequence ID" value="SPAL_0000859400.1"/>
        <property type="gene ID" value="SPAL_0000859400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000859400.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8272" checksum="470BCC830174F989" modified="2015-12-09" version="1">MNNTNTQQQNSKSPNGKESQKKATMVLGRDVNLLQSKQNMNSNEKSYDDTLKNVDELPEDDESIRNCIEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSJ8</accession>
    <name>A0A0N5BSJ8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty-acid and retinol-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSJ8"/>
    <dbReference type="STRING" id="174720.A0A0N5BSJ8"/>
    <dbReference type="WBParaSite" id="SPAL_0000884000.1">
        <property type="protein sequence ID" value="SPAL_0000884000.1"/>
        <property type="gene ID" value="SPAL_0000884000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31418">
        <property type="entry name" value="FATTY-ACID AND RETINOL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31418:SF7">
        <property type="entry name" value="FATTY-ACID AND RETINOL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895107" description="Fatty-acid and retinol-binding protein 1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000884000.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20271" checksum="2B0E43E65F65A045" modified="2015-12-09" version="1">MISIRLLVIAVVGITVVAGNALPYDQIPAQFKEFVPEEIKEFYKGITHEDRAVLIEIAKNHDNFANEEEVIAALKEKSPALGEKAESLYKMVKDKVNSLSEEPKAFAKELVKEARALRPAPGEKPNLDKLKELVNKYIVKYKELSDAAKTELRQVFPKMHALADNEKFQKLVKGLLNVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSL6</accession>
    <name>A0A0N5BSL6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with signal anchor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSL6"/>
    <dbReference type="WBParaSite" id="SPAL_0000885800.1">
        <property type="protein sequence ID" value="SPAL_0000885800.1"/>
        <property type="gene ID" value="SPAL_0000885800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149:SF9">
        <property type="entry name" value="PROTEIN CBG09996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34149">
        <property type="entry name" value="PROTEIN CBG11905-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894967" evidence="2">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000885800.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11995" checksum="287EA2B46EB22E2E" modified="2015-12-09" version="1">MSIGYYLTSAIFGTFVFLAQGAKNIDDLKKTVDDVQTIEGGSKWCPIPLTGKECPPSSIFHYYKCCGTLMTDCCFNLQNWLIITLIVLAAITVIGIVMSIVSWLFCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSX8</accession>
    <name>A0A0N5BSX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FA_FANCE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSX8"/>
    <dbReference type="WBParaSite" id="SPAL_0000896900.1">
        <property type="protein sequence ID" value="SPAL_0000896900.1"/>
        <property type="gene ID" value="SPAL_0000896900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000896900.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="79797" checksum="76029E23CA708BFB" modified="2015-12-09" version="1">MSDSEDEFVSASEGEELSSENSFSKCSMSTSLSSRSVKDNVAKTIPPNLESSSSTNLKFDKKVMDSENEEKTPLDGTATKVTSKEDFHNEGQFKKPVTFKSKEEEFKKVESKKKKNDYDNDWDCDWDNVLEKSSSFKKIEKIYTACGAPKDDIHDELESLSDEKSLESESQTIAAKIQEAALETVIETTVEIRPLGGKNIEEKSEEIIPESVDEKIQKDIVAVAKKELKINEPIKIEEPPRVQHETTGHEEVKTEKVKPRIKVLKLSKKIGKKEDAPPKPLNTDMLAPNRDSVSRVNSSQSSSNGTDISSYEKVDTPEIVEDNDWFDEVAREIITKNEPKKSSRKPRSTNLFDWSAINAVVSSVGDSISNVVESSLGIPSAEEMARVVSKYEKETPKEESSGKIVNPLDRLCDNTQYQQDIPSISGIFSGFVNTSLDALETLGKKTFETLTVTEMDGDRERRKFLFEPEKPGNLSDILKELRNKEKNENESTQNMRSVGYGSTSQKSLSTSFVHLFEKHGGLFNLEGLEMLTQRVNHSTSTNTSSFNEHISEFNVNDISPISMDKFEKELKKLVKQVKVPFNPNHILGASKNQEEIYLESTLLDNSSIETIFENAMDALALLTAESVQVIHKLGQLFSIAPQIPDDVIVIEMTKLFCRRVTYFSEEYANLFNSLVSDPKIDEMVTNIFYESTNATLYIKKAVALLKPFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT75</accession>
    <name>A0A0N5BT75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT75"/>
    <dbReference type="STRING" id="174720.A0A0N5BT75"/>
    <dbReference type="WBParaSite" id="SPAL_0000906400.1">
        <property type="protein sequence ID" value="SPAL_0000906400.1"/>
        <property type="gene ID" value="SPAL_0000906400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000906400.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="44171" checksum="1EE03190FD3576E7" modified="2015-12-09" version="1">MTDKDTNVNEVVPDFNIDGECCIEEPENDEIYFIKSLLKVGRINLCYSGIRKKTNKEICIKPLSVNGHLMIREILNFFKSEPEKCKVFLPIIDIVIADSIRTNFVVLEGTFINLAETFNIKDKEIVDLQHIFLKHSLRATKFLHQNGFIHGNLSITSFWVKFNSEKEAKCIFHHKYIGEILLADLEYCIKIKDNGDNSKIKKISQQRITSKPKSYKYCALGLHKGEKMCMKFDFESIYYILVQLYEKKLPWDKFSDDERLIRKEKQKMRSPTYDFYRNIPEHIAEIVCFIDKKSPDKVPDTEDIKKRFYHYLKKKTFYDEDNYILGDSDYTRTAEYYRLIRKRREESNEPFSKSIYEEIIGEGKKQKKNSPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUE3</accession>
    <name>A0A0N5BUE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUE3"/>
    <dbReference type="STRING" id="174720.A0A0N5BUE3"/>
    <dbReference type="WBParaSite" id="SPAL_0000946400.1">
        <property type="protein sequence ID" value="SPAL_0000946400.1"/>
        <property type="gene ID" value="SPAL_0000946400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000946400.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8429" checksum="3F4490564C5A8463" modified="2015-12-09" version="1">MTNILFNMVMLILNDKYIVQYGDKHIKVSELLDILSDEFRVPRRRVHSMIKSMDHWASKAKFRDDEFIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUV6</accession>
    <name>A0A0N5BUV6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000962400.1">
        <property type="protein sequence ID" value="SPAL_0000962400.1"/>
        <property type="gene ID" value="SPAL_0000962400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000962400.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41266" checksum="96F35C3769D25439" modified="2015-12-09" version="1">MTLEDSMYKYFGMPFPGSFIPNHNSPFNDKMTYKERFQNMLAHYVGETVFHILNDKMSLQKEFDKKYGVGFFDSKTVVGDSSFLILNSNPFLDIPGPKTPKMVEVSGIGIKDTKPLDEYWSKILSLRNKTVLVSFGTFTKAIYMPEDLKNGLLEAIRKLNDITFIWKYEEPEDGTGKDIENLVLSKWLPQSDLLNDERLSLFISHGGMGSITELSFRGVPTILIPIMGDQLRNSRLVERQNYGIIMNKLDLANPDILIKNIKTVLDDETYRKNAKIVSRRLNKRPIGSKKLLIEHIEFAAEFGKLDMLDLASRNMGVIEYYNLDIIFPVFFGLFLFVCFLLYVTLKIVKKLFTSKVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUY8</accession>
    <name>A0A0N5BUY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUY8"/>
    <dbReference type="WBParaSite" id="SPAL_0000965600.1">
        <property type="protein sequence ID" value="SPAL_0000965600.1"/>
        <property type="gene ID" value="SPAL_0000965600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894969" evidence="2">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="213"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000965600.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="67151" checksum="1E7A56A6BD59EEB4" modified="2015-12-09" version="1">MFIGLFLFSYVISLILTFIDCTDNISKRDVVKRVDENNEEYYGIGEQVKKIFKRNDLSIGVSKIKRDTNSAINTASTNPLTNNDFIMVIKRNSVLDKNVTAEFKDIVSNKRKKRSIVWKPIQRKTARKRKQTTKRKNTSKRKRTTKRKIKPKRRPTIKHKIKPKRRPTTKRKTTSKRKLTKKRRTTPKEIPKATTIKTTTSFKKPSSGIDIDSLRKKYLDQTNYYRKLHGAPSLTRSKKLEKLAQAYAMKLARKFRGELIHDPDRRYGENLAVMPSDEINDAIEFWYEEVKKYNFKKPGFGMNTGHFTQVVWKDTKEIGCAIAKLTKKYSGDFIICCKYYPPGNYHNEFVINVLRSLFHYLIAFGFLLLVDSEPYRQPYVESPIVYLDNNNDNTNNEVTIKTPSTTTISTITKNPTDINKLRLKYLNDTNTFRNRLEIPNLRYCLLLQDAAQQFTDQVARNFNGTFTVDSESKYGEYNAILNSNMVEEAVMFWLNGVEYFDLKKVDMKVNSARLGEMVSYYTKEMGCGITETSGDYEGHYLVNCKFYPNMNKQYYKHYEKLYQQKTNVLEQKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVA7</accession>
    <name>A0A0N5BVA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000977200.1">
        <property type="protein sequence ID" value="SPAL_0000977200.1"/>
        <property type="gene ID" value="SPAL_0000977200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000977200.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="62983" checksum="1D3DE9DC0F1CDF81" modified="2015-12-09" version="1">MDAEEISFMNIMEVGLVRKKIFEYLPSFKNIRHLASTCWKLNQIIKNEKITKNLFYDCGEITIRFTMIDAIRDFTDVQEESKFEDYAFIKTDHLYSNVIIKNENFDRDRFISGNTVGISFSNAVGRLSSEKYIPFIMKLAQQYNINYEERKDLTCLQLSDETFSQGCSVLLKVLPYLHHENINTIKIPMTFFPTNSYKYDGLLNGIFDRFPKLYRLGIDLSGGSIFVSDLSLNKDAIYDIMGQLSRKKNATIHFYYKNDDHYYYINNFSVFFESAMKHGINVTMDESTLLRMEERGISDILKHHNYSIEQHVTTCKTCIYSLDIISRDRLRKIRYYENLEKFCLILNLNLNDCSLEENFKALGNIKSLNNLKKVIAIKLTFVKPHDGISEDEIEIFHRNVKFLIQLLPKSVKRLRLYGVPKLTYDITRTIKRHIPNIEVLSLCNVSIEETDCLSVFKKLQVLVIRGDITVKIPDSVKLFAINTMESTKKDINQKLFNEYSKKFSKSLTHNKGRTIFFNDINDWRCYKQMLQMERFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVW8</accession>
    <name>A0A0N5BVW8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Corrinoid adenosyltransferase MMAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:co(I)rrinoid adenosyltransferase MMAB</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cob(I)alamin-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)alamin + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:56796"/>
            <dbReference type="Rhea" id="RHEA-COMP:14743"/>
            <dbReference type="Rhea" id="RHEA-COMP:14744"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:56797"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVW8"/>
    <dbReference type="STRING" id="174720.A0A0N5BVW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000997400.1">
        <property type="protein sequence ID" value="SPAL_0000997400.1"/>
        <property type="gene ID" value="SPAL_0000997400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000001">
        <property type="entry name" value="Cob(I)yrinic acid a,c-diamide adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="12">
        <location>
            <begin position="37"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000997400.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27394" checksum="F5626000C9F32FD4" modified="2015-12-09" version="1">MIRHSLKLTNTLFNIPRILQMSDEAPKRRKFKAGRGTGDKGKSSLYTNERRMKNDPVFQALGACDELNSFLGICREFAAQDKELSDIEELISTIQCCLQDLGAHIATPQGTGSERKQNLTQFEEWYPKFIDNKIDEFAEDLPPIRQFILPAGGILGSHLQYARALARKTERKMIDLHTEGSINDHSIKFMNRMSDLLFVLGRYASVKTKSLEKLYLKPMKIDDDTCLTWKTRDFSKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW09</accession>
    <name>A0A0N5BW09_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW09"/>
    <dbReference type="STRING" id="174720.A0A0N5BW09"/>
    <dbReference type="WBParaSite" id="SPAL_0001001500.1">
        <property type="protein sequence ID" value="SPAL_0001001500.1"/>
        <property type="gene ID" value="SPAL_0001001500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="326"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001001500.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="73146" checksum="A873F82CCA59C811" modified="2015-12-09" version="1">MAPTPQYPTPQLPGSEENLNPRNSGSQTLSELFKSLNIVEGTGTYANIKNVGHTGVGTNIMTNCFQITGKDSDVKSHVYQFDLGIFLTVMKKNGQTAKVEFNKTYPEGFKVDDYYSQTLKIMMIKFFPLLQHVLKEQLGIPERASISDFHRLFFTVDEKLKNHVESQKGVWRIEVPAELIGYIQKISEKLKNVQGASLEFKFATEFDFSYCLFEESVNSKQGMQYINLIVDMKSNMNFDEWASYQNGKSYLIAPEKHGFKEADMPPLPDGKYLGIGSFSSVRQSNDIERNDSGFIYVVDSIKTAFHAPQLLNEKFDELLKRIGPSGRIEKVPFHGQTADKVLKNLKGLVCHCIHLNRKEIKIESIDNIGADSRKITVGNETMTVQEYFLKTYNIALRFPQHPLVVQKTKRFENGKEVKGFNYYPMELLEVADYQRVSQKAQTPDQIKAMIKACATNPANRINDIRRLFGALQVTRNDFLHYLNLKVQETPKSVTGRMLESPKISYANNRIVNAKPDNKSWDIGYQDQFVIPSRVVNWGCYYFEPVGMGKITYADIKQFVDAFTRQARQRGVFIENCYEIKQIPQDEMHLKDLFVYLQNEKTDFALFLTPDTVTDMHQYIKLFERLYGVTTQDIKHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXA9</accession>
    <name>A0A0N5BXA9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXA9"/>
    <dbReference type="STRING" id="174720.A0A0N5BXA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001044200.1">
        <property type="protein sequence ID" value="SPAL_0001044200.1"/>
        <property type="gene ID" value="SPAL_0001044200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001044200.1"/>
        </source>
    </evidence>
    <sequence length="751" mass="86154" checksum="57211B315B56A5A9" modified="2015-12-09" version="1">MNYLSNVRRLSTFIDKKEIEFYSKLDKSWMNEIGEFKGLHSLNKLRIPAILDSINSSNLKNKKILEVGCGGGILTFPLVRLGASVTAVDPCKESIIAANNFANHILKENYRHRVSFECTTVQEFSKDNKNIYDIVIASEVLEHVPNVSNFMDKCASLTKCNGILFISATNKTFLSNLLAIKFAENIAGLLPPGSHNWDKFIKPGYLIKILLENNFSVKSYRGLTYNLLTNNWLWINNTDFKRLGFQYYSVNNKIRYQLTFFLIICHFFQMSFVCIICSKPYTGTSTEHALYSTKCGHVMGESCLKKWIRENSCQGRFNCPVCRTILIYSDCHPIYNLPIESLKSKSDSSKDKYLSEDDILTDYLIGRLEKGSTFFIETGNRRMFRKFIEFFDIHNGYILIAAFYWRGFGDVEYNRGTGSHKFVIQIFEGTNIFYSEDFGSVPFTAVAFNKFREDGIEFCVGFENGSLKSRIFSLANEDFGIPNGGILINEDGQINSICFLDKNKVIYSVGECDGECNIFSVRTDKFCVKENWLGNINVRFKTVTNLTVINDCVLLGIMYGNIYVFEKNKIPYLLYSGGYTQVTNYTYDSVVDMILTVNSSPYGFNDYWENFLKDIRDERIVSHEIRSISKIFKYDNEGCRREVYINYPVGDFPDITSQVIHEFSPTIISTKYCDKYLIYSFIPNAENSMLQVHLVNDALKVVGKTKIDDFDECIGVFALEKPQVLLARVVKIPIVIIFHYGFKTLNFYAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXJ8</accession>
    <name>A0A0N5BXJ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXJ8"/>
    <dbReference type="STRING" id="174720.A0A0N5BXJ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001052400.1">
        <property type="protein sequence ID" value="SPAL_0001052400.1"/>
        <property type="gene ID" value="SPAL_0001052400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="310"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001052400.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="61669" checksum="E2383170D240C40E" modified="2015-12-09" version="1">MNTNQVGKTRRARSRDRSPTILADLLRKSQLLNDNKKDERIIEELPTAEISSTAKKAAARANDPEITAEELEKMAADVGDGRLLKMDKDYTNEVESLIATCEKQLASGVDLVTVLDNTSRLEKLTRLGMDMKSNKNILMYITKICVERKAWSTLADQVTVLSKKRSIIKFAVSKMISACCEQIDNIENEKERDQFIESLRNVTAGKIYVEIERARLSRRVAMKMEREGKINEAWDIMMELQVETFGSMPMDEKVNYLLEQIRLSIVRGEWIRALVISRKINRRYFDKDPTEIVQNLKLVFYNYMIQISLHDEEYIEVCRHYLAIFDTPIVQSDSVEYEHALKCATLYVLLSQHSNEQWDLLHRISNYKKFKDIPVFVQLVKLFTKEEIIDYNNTILPHFKDVLVNGTPDCVSTNVFQKINGEEKRWNEFKTRVGEHNLRMVSKYYSKITFDRLAVLMDCSVEEMETFLCDLIVNGIIPHAKIDRPRRIINLEEPKNHLNVLDAWASDVNKLTGLLNNISHLILKEEMIHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXP1</accession>
    <name>A0A0N5BXP1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
            <ecNumber evidence="10">6.1.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate--tRNA(Gln) ligase EARS2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:64612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9716"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18398"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EC" id="6.1.1.24" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXP1"/>
    <dbReference type="STRING" id="174720.A0A0N5BXP1"/>
    <dbReference type="WBParaSite" id="SPAL_0001056300.1">
        <property type="protein sequence ID" value="SPAL_0001056300.1"/>
        <property type="gene ID" value="SPAL_0001056300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050561">
        <property type="term" value="F:glutamate-tRNA(Gln) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="18">
        <location>
            <begin position="13"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="19">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001056300.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56632" checksum="2A155BED871ABC5E" modified="2015-12-09" version="1">MFQIFVRSCFSDVRVRFAPSPTGKMHLGSLRTALFNYLFAKHHKGQFILRLEDTDQNRLVPNCGEEFEKTLSDFGLNVDESPLKGGNFGSYKQSERLNLYQEKSQELIERGHAYHCFCSSERLDLLRKNAIRLNTIPKYDGKCRNLSKEEAAKRLVNGEKSVIRYKFDNHESSFYDIVYGSIHQKMNEGDFVIIKSDGFPTYHFANVVDDNHMKISHVIRGMEWISSTGKHMKLYKSFNMNPPTWIHLPLITRNGDKKLSKRDKDAFVDFYTKTNGYLPLGILNFLIRNGSGIKDFECGKLYKIHEMVENFDCNLIGRRNFMLDNDSLENYGKLSFKEADFDNQLYPEIINRLKKNIDKEYVEKVVDFLKKNEEGFSKLSLLDKDAPFGFFFSQTSNLNNLQSYFELGTVKKMLSEVILLDNLNVEKFREISHNNDMKYVQFFKMLRLAFIDSVNGPPLSELIEFFGETECKNRLQNVILLINQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXQ7</accession>
    <name>A0A0N5BXQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001057800.1">
        <property type="protein sequence ID" value="SPAL_0001057800.1"/>
        <property type="gene ID" value="SPAL_0001057800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF88">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="875"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="325"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001057800.1"/>
        </source>
    </evidence>
    <sequence length="943" mass="107629" checksum="A48ED039E0AC269B" modified="2015-12-09" version="1">MSKISSSNNFNIIPSIKNLEKNDTCIIRNFSNTEASSKDISSLSSSLDTHKSSNAFVKIIQKGYFNWAKIVTRYSYVIILICLILTLIGTVKIAITKNINDITGYTPYGARSRYEMKVSQEFSDEHGRGPTVFLSILPKEGENMMKPLLLKEAVKIHQLIMNNFTIYNKITGVNETYKNFCHGFCNINEPLVQFYNGYKFQYDLMENKEKLSDRIILRYPKSQFYGREFGLQSNFFGVKLKNSSEMKETDITNLEYAKMVGMFYIAKFKKGWTEEDVKDFEMQFISFFTKEYKSEYIRVLPLSTTYVELEVVRAGMANVPYLSLGFTIMVICSCTTVLLSSYYMNQASIHKISLAFNACVCPFMACGTALGALFFCGVRFGSVLCVTPFLVLAIGVDDAYLMIHSWQKVCKDMRKKNDPEDSVEKRLGLVLQETGPAILISACTNILADLIGTYTGSPEITLLCIGNMSAIFVDFIYQITFYCAIMSIIGKYEMANERSLSNKLNISIGEIVQNDKVIEGVSVKSNESLSKNNQLLREFVKKIINGYVNILTNIWFNLLMMFGWISVLIICSYGIANIKILLTSEKLFAMDSPLIEINQLRENVLIRDCTQASIYITNSIDFSKKDKFNKFMEFVNEFETDKLSLGNETTHLFLRDFLEFEKHKVEWDNEESGIENSNRTDEIPYVEKDISEFLKWPEEEHWNGFVKLSNNNTKLKSFFFNCYYHGDVLSDWVERGKLMDRLRSIVDKYKPFFNATVFMNDAIYFDLIDNMPRDAIESSITTIICMGFICSIFMFKFKPILIAMITIASIIVLTLGSLHWTGTTLDPVIMASILISIGFAVDIPAHVIYHFHVSQLNQTSNENNKKKLKNILKEVITSVGFPAFQAALSTSLCISVLLLVNVYMSRAFVKVMVICLSLCLYHGLLIVPTVYAIIYHLRKLICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYK3</accession>
    <name>A0A0N5BYK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYK3"/>
    <dbReference type="STRING" id="174720.A0A0N5BYK3"/>
    <dbReference type="WBParaSite" id="SPAL_0001085500.1">
        <property type="protein sequence ID" value="SPAL_0001085500.1"/>
        <property type="gene ID" value="SPAL_0001085500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000130">
        <property type="entry name" value="Protein CBG03641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001085500.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17309" checksum="118C875676AF2B90" modified="2015-12-09" version="1">MNMNNGTTNINVPVGTGIQCDDRRMCALCSGSIGEEALMAMHRLWHPEHFVCNGCKKPIKQTYQIADNIPFCIPCFAARFNPKCAACNETLVDTCLVALEKHWHPRCFKCTMCHKPLPNGEFYTVDNNPYDLDCHWAVRLDKRNEKMEIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C191</accession>
    <name>A0A0N5C191_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C191"/>
    <dbReference type="WBParaSite" id="SPAL_0001176900.1">
        <property type="protein sequence ID" value="SPAL_0001176900.1"/>
        <property type="gene ID" value="SPAL_0001176900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001176900.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37343" checksum="09F992DE98DA3023" modified="2015-12-09" version="1">MSTITSFGYVNSSHTFFSFSTDNGYVCNIPIINNQEDVVAFNKKFHGDKPQKNCNFILNNDFISKIILYPCDGTLQSLLIQRDKTNSSEITIATLDNQLVDTLKLLHYCDKIQWNPNEMGSEKIGCKQLNAIHIYDVEAGAVTQNFISNGVLDFQWDKDNENLIYTGDNYGLISIHDLRQLNETKFGQKVNKCKKSQIEILDNFIFITTTLGDCNIYDIRNQKIVTNFKLKSQYTPKDCLPISNKHINCPIFKVKYINNLYTYVYLYGTDFVVRKFLKSMENSEEEEKLIQTRHVYSINDFHFHPTLALLTSVSDRMDVCNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1K1</accession>
    <name>A0A0N5C1K1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1K1"/>
    <dbReference type="WBParaSite" id="SPAL_0001187500.1">
        <property type="protein sequence ID" value="SPAL_0001187500.1"/>
        <property type="gene ID" value="SPAL_0001187500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001187500.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8148" checksum="AED85E689BB674F6" modified="2015-12-09" version="1">MSKKLTKKLGKKKNKRPMVPPPIITITEAVSVQDNMSVSNISTLETKKNKKKDKKLLNPGINDALWPFLIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1K6</accession>
    <name>A0A0N5C1K6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1K6"/>
    <dbReference type="STRING" id="174720.A0A0N5C1K6"/>
    <dbReference type="WBParaSite" id="SPAL_0001188000.1">
        <property type="protein sequence ID" value="SPAL_0001188000.1"/>
        <property type="gene ID" value="SPAL_0001188000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895202" evidence="1">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="141"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001188000.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24010" checksum="E3ABF1EC227881CF" modified="2015-12-09" version="1">MFSCILMLLTIPFISSQFLGAGGGSSCCCGCSAPQPSFCGCSQPVVCPPPQPCPPQRPPCPPPPIAICPPPAPMYINPSCQNCPISPSSGYRARYIVLRSNKLYKNEDNQEDEGEEKLTFHKDMPLYDNSTLNDENKDVIDKKCNSEEMRNIILQNIIPNDALKSKHAIHEAIIQTYENPIINVICSESSFTYLVIGIQKFCESQKDGVICFIYQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1U5</accession>
    <name>A0A0N5C1U5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="22">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1U5"/>
    <dbReference type="STRING" id="174720.A0A0N5C1U5"/>
    <dbReference type="WBParaSite" id="SPAL_0001196500.1">
        <property type="protein sequence ID" value="SPAL_0001196500.1"/>
        <property type="gene ID" value="SPAL_0001196500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="366"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001196500.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="80042" checksum="636384CC6CD05659" modified="2015-12-09" version="1">MGKYRDESVSEDGEIVSSSEDERRWKRRKHEREDKRGIDKSHRKEVHSRKSRHSSRDRREGRKRSRERSTDKYRHKRDSRSPRKHHERSSKDDVKESRHRHKDRHKHESSKSKRHRSHSKERERKRRRSPEKSSTKEENSTKNKGNDIVPIDWVDEKSEDEDAELQKRRERRRKIMEELIKEKTNDNNSVDDNTMDTENNTQVSNDNLMAQPISDDEEEEPKENKLDSVDPQPIPNSSTVVDLKEVDKDEQNPPTETNENIEKDFFAQLKEKMDHIKKNSDTKLDSEAIMRLAEEEKKQQLPIHIEEEKPTTVSFDMFADDLPDSVLEKPSFTIATSSNNPNLKDNYDDTEGYYRVRIGETILKKYHVIGYTGAGVFGNVVRARDVKHNNALIAIKIIRNNDLMLKAGRKELEILKKLNDADPQDKYHCLRLLTSFLHHNHLCLVMENLSMNLRELLKKYGSNVGIHISAVRAYAQQLFSALGLLTKCSILHADIKPDNILVDETKIKLKLCDFGSALHIADAEIAPLLVSRFYRAPEIMMGLPYDYGIDMWSVATTLYEIYTGKTMFKGCQNNEMLKVIFELKGKYSNKLIRKAKFKDEHFDSNCNFVYHGSDKMTLEKNTFCTSIKITRNLEEELRGNQNLDKSNYQQMLKFKSLLEEMTVLDITKRITCIKALQHPFIVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2K5</accession>
    <name>A0A0N5C2K5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2K5"/>
    <dbReference type="WBParaSite" id="SPAL_0001221500.1">
        <property type="protein sequence ID" value="SPAL_0001221500.1"/>
        <property type="gene ID" value="SPAL_0001221500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7381" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001221500.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35958" checksum="42D1F92EBFB5E03E" modified="2015-12-09" version="1">MSIIYCYLFYIFSIFSKLNSDIVVFESAFKAIENRYFWYYDYTTFASKEDFLEHIGETYPEFISKLIFIRITGEFNVLGEFIRYDPVKLCKICLPQKDKPKSRVGLKRVQFSNDEVIVRYSLNGEITYECDGHIVPTLQELAKCALKKRHQKFGSTCQKTSYRDEALVCTIKQSRKNKTKSKLFCENIDVIQLLNYRKGLKKSTFSDKIWSSIWKNRYSYGCFSLHNYRLLKERYIREINAYRSFYKVSPLTEDFKLTQLAQTRAMVLANYGELSQSRVGLKRVQFSNDEVIVKVFSKWRNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C374</accession>
    <name>A0A0N5C374_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C374"/>
    <dbReference type="STRING" id="174720.A0A0N5C374"/>
    <dbReference type="WBParaSite" id="SPAL_0001242900.1">
        <property type="protein sequence ID" value="SPAL_0001242900.1"/>
        <property type="gene ID" value="SPAL_0001242900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001242900.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17698" checksum="7409C0FB8AA6DCE5" modified="2015-12-09" version="1">MAIDKDPTEVSIGKGPAIVSVVKDNGNKVELVVKIPQLKKRGQILRKIIGTIKKPSNPSKLCGNARFVEYTLDGTSLHFVVNVFKSNTKKNQNNETLLGSYTCDIKQFPSRISPESAEFEVLQASSGNAYIGLTLIKVGDISTDWKEFQDRNGTIDVSAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4V0</accession>
    <name>A0A0N5C4V0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4V0"/>
    <dbReference type="WBParaSite" id="SPAL_0001297900.1">
        <property type="protein sequence ID" value="SPAL_0001297900.1"/>
        <property type="gene ID" value="SPAL_0001297900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001297900.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10465" checksum="E4B6BEFCF96045F0" modified="2015-12-09" version="1">MKRAPQYMFVHIDRNSSSIFNDAAVEIERRKVYDFVGISYIICGAITYHNQHYTAYVSSEKSWVQLNDSLCSICSEFPQDQVVIAVFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5D7</accession>
    <name>A0A0N5C5D7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5D7"/>
    <dbReference type="STRING" id="174720.A0A0N5C5D7"/>
    <dbReference type="WBParaSite" id="SPAL_0001316600.1">
        <property type="protein sequence ID" value="SPAL_0001316600.1"/>
        <property type="gene ID" value="SPAL_0001316600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF25">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="NTR" evidence="6">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001316600.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15887" checksum="87EDF2AF9FE6B694" modified="2015-12-09" version="1">MSLQCTCRNMTTKDIYCQSDFVIKAKILDKTPKTPVNAGILSQNIRGITYKVQFLNIFKKDDSKPFPNQIMTASNSALCGVNWLEIGKEYYLIGDQEKNSLFINLCSIINFHPPDISSSLSSPSHQHNINVIKENDSKIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Q7</accession>
    <name>A0A0N5C5Q7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NDT80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Q7"/>
    <dbReference type="STRING" id="174720.A0A0N5C5Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0001328400.1">
        <property type="protein sequence ID" value="SPAL_0001328400.1"/>
        <property type="gene ID" value="SPAL_0001328400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="264"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="580"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="7">
        <location>
            <begin position="264"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001328400.1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122097" checksum="E09B8B0EFEF8A4ED" modified="2015-12-09" version="1">MAKSQRLPIREETGFGDPLGDYSDGFNILQFINDNDSQIDSSLDPNRYPSQAHAYHQNTVMNCNQNNYITNNMQRRPVVSNNNPESNGLNSQVMYTGNTRLPDSPPITDISGGNSSGSPSSTSEPPYSPDHYQNYGLVQGTPINNRNQMVVEVPDGMPQMNIPRELVNHQGQIITNRMPQQRINNGQNEYLNNYVIPQNVSLIPSINTMNVNGNRQNCPVNYMMPQQSYIIGDVYGSNNQLSSAEAQSIRSVQQQQMPIQQQQPRSDGGPVNKRKRTEPHHSTPTNIKQEVMSNNKGYTMQHTNISCTSSPRTPIHNVPHTTQTPGPQLSDDNDENITQRAIRFSKFQEEFWHPLFDENHQPLCLLEVHVVADKGFNYSQVDGCFVNQKKNHFQITVQIEALDAKPPAYVKVNNEYHRIKDFKLAFCGVKFEMPTTEIQIKQSQTDRRPLVHEPVLLEIHERRMTKATVPRLHFSETTMNNHRKNYKPNPEQRYFLLVVKLLAYTEDDQTVLVQAYQSEKVIVRASNPGQFEPPDTDVAWQRHNNTLHFNGNVAIGTEKAVAPLTVNGNIFVSGVINRPSDRRVKEDITEIDTKESLNRLNNLRIVQYKYKDEIADEWGIKEGDRHRVGVIAQELAEVLPLAVKDNGEYLTVDDSQLFYDTVAAAKELCKLTDNLEFKINKVEKFSQHLKKEVKKRDRYASISSSISEISSLCNGGEKSLAVSQYSINTIGTIQNIDDNVKSNNENNKKKRQKRICNNRCRRQPLETTTLVSRIAHISISILVLLMSCCLVAMSILYVMDWYKRSNSHYYRRQNINGTGLYSKNSDIGHLYENVTIHRLMPLPTFQPNAPILFGECNSDFCEEYCLLNKGKYDTVDQQVEELDGVVSLPDDNDIDDYHFSLSKLSTNSGTSTPLYSGVDIFLPTLNISIDSDYCHENSCNFSTGQYDLYIPVSTYMPAINIEVIFRFNNSVFVDNCGPVKYFDHKLCPSGGIGKGHDDFDNITPYSDEFTDNYYVLPIGQYIQSAYRFRVGFTSNACKIADDQRGHSYDEYTLVFYRHWPSSQQKITGLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6B0</accession>
    <name>A0A0N5C6B0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase-coupling factor 6, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6B0"/>
    <dbReference type="WBParaSite" id="SPAL_0001348100.1">
        <property type="protein sequence ID" value="SPAL_0001348100.1"/>
        <property type="gene ID" value="SPAL_0001348100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001348100.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10160" checksum="867AA467E3DAA4C3" modified="2015-12-09" version="1">MLRRIFKRNTTKLDNSSKTFAAAYGLLKTKWLKEQMDAKSLSQAEQNQVSSRQNVELLQLITNYGLDEAQTLRQFPLPTLTDNDLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6D1</accession>
    <name>A0A0N5C6D1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XRN2-binding (XTBD) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6D1"/>
    <dbReference type="STRING" id="174720.A0A0N5C6D1"/>
    <dbReference type="WBParaSite" id="SPAL_0001350100.1">
        <property type="protein sequence ID" value="SPAL_0001350100.1"/>
        <property type="gene ID" value="SPAL_0001350100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11952">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="2">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001350100.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42968" checksum="CEC0A3F02E056171" modified="2015-12-09" version="1">MEEEVPEWIEKARLKHETETEWMLREAFLKKNFNDYNKEKLIMYSRVFVNHYMMGCQYDPRIIDKVKEMAIGISLERLRSEKRSFTNLTAANAKKYSGKKIKGGVPDIPVYTRYENKTDSPSSPTRKKGRYDSAVQSTTAEIVKKKKSDEEVLKDELLLFRNKYTLRDTMGNPENILSAFCQDIGKEFVYDVDSDYVSKIMIGRVLVFSHSFYFDVDVAGQASFVACNILINGNLEVVKSADDNPLYDYLLLSDNQNPDNAYFHFISSFLSSLPHQDIPEDGELRRHVERMAQESGLTFYVDKFSDGGWAMDITLRIGELVVGMKHLNKEENKQAEIHINNLIVTFLEKLNTECGESKLVIETDSQGILCLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6R1</accession>
    <name>A0A0N5C6R1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6R1"/>
    <dbReference type="WBParaSite" id="SPAL_0001362600.1">
        <property type="protein sequence ID" value="SPAL_0001362600.1"/>
        <property type="gene ID" value="SPAL_0001362600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001362600.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71278" checksum="5AB11DA4CBFBA597" modified="2015-12-09" version="1">MVLPKKRGLSKRNNKQTRISIFKKSKNVNSKNLGRRKNSTSKKKEGKSNLLPSVRKRKRTIIKRNPRRDIVPKTNKGKFCILNSSEINNIKTILFHKPIVSKIAYNLTSPKDRLYFSLVNKVIYDSIKDVPFVGTRVLDNRRLLIEVYATSINSAGGSISVSIANVTRKFIFFDSYASDGNFAKMLKFLKYFRNQVHQICIERKVTNGKFHNFIEIGWLPLILKHINKENFPNLDILSFCYVSFKNTGYGSYGYLPIAKVCFHECEFGDESPFIFPKKMDQLYYDSVNNIPVKLLSNIDVIEKGAGECKYSLSSVESYNTFVNFIQQSNVFEIEGQLTMNMLNFQTVFLKDHIYEFIELRIDNGKTIKVLANLKHLLTLKLEYLKELILVFVKTPIVLSSEFVLTLCEILEKAKNLRILRFCGDYRQRVRFSEYDSEEKIFGSISNTVNVLEVSVGNWQTIRGMSYLANRLTNLELIILNSIIYPSFDIPTIFHIFKNVRNFVISIVEKHSGEIAHQWIVEFLNPRNINNSTKIFDSLIVSISGEKFYNSIIDVIKGRTSELCNQVDLSLLENGICEFLVCWKTQNLRKVRRFTDTRCRHCCAGEENKILTSLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7E7</accession>
    <name>A0A0N5C7E7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C7E7"/>
    <dbReference type="WBParaSite" id="SPAL_0001386100.2">
        <property type="protein sequence ID" value="SPAL_0001386100.2"/>
        <property type="gene ID" value="SPAL_0001386100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2380"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="176"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="499"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="617"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="737"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="858"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1626"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1871"/>
            <end position="1974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001386100.2"/>
        </source>
    </evidence>
    <sequence length="2478" mass="282086" checksum="C7FCC1752E0273D7" modified="2015-12-09" version="1">MRKFYEVFILLNIFYIKNNYCNTITNNTDLGKLCEDGLPLLTSNDQPVPCNEMSNCPMGFWCHNGGIYPSLYYCCPKNREVTNICTLPKGIGHGFEVSTRYFFNIHTQECESFMYYGIGGNENNFPSLRECKLMCGMFSKKIQTNFLNENPFIETMADSILKISNDAPVRSNFDPCTQTPDIGINLDGHSKVEKRFYFDKILSRCIQFSYKGYGGNFNNFKTHDDCEETCGSGKLRVSSCFEKYTNGTGNMKILRYYYDYKHRVCKNFFYKGRNGNNNRFVSRKQCTQLCIVSLQPEKILNYGSGISIISSTVTIPTTLATPISSTTTTTTTTTITTTTISQSTSLPRLVFNSFKNNNISSGNTKVVENNIKDESYNIPRIIKIVAPINNHENEQFHPQQQQQNFINANNNQFNPNGYESNYGNNFGNNEFTPNNNNQEIFGFENYYKPLPYDGHISITNVTNKSGKRRRPVQEISSSAYKEFVHNLTDHKQTPVDDICKLPLEEGSGNLFIQRWYYNPTFHNCIPFFFKGHSPNSNNFYTKNECIKRCINNSKTSKHNIKEHYKHICSHGIPSLDLYHKPIICNSNDNCFQKTHYCSYDISNVQGYCCPKSFTSPCEQELQIGYQEYNNKNSEKDTVIRYYFNKDTFTCTSFKYTGIGGNENNFLTIGECRRQCPEYINPCPVGIPYISKINENVAFCSHINQECPPNYWCHIGGSKRTSTCCPMTNEEALNEDPCSMNLIIGEGDEALSRYFYNKRTKQCESFIYLGKRGNANNFYTKTDCEAMCPVFENPCGFGSPFFTTVTDKDSEKDLEEESQPMFCSTSENDEESICPDGYYCHIGGTSQSTVCCPITGDPCDMPVSKGNGTLILNRWYFNSKTKVCSNFVYSGIGGNANNFLSKEDCTQTCDVMLNPCPVGHPHITLDGEVTQCGDSSTIDGNDNGNCPPTYWCHYGSSYETSTCCPNAGNPCILGMEEGEGTLNVTRYYYDYKSRKCKKMNYKGMKGNQNSFLTLASCEARCPVFKNPCLNGEPEKINNNEDIKFCSMSNPKKGCGDDYYCHIGYSEESTVCCLKINDNPCSQPIIRGGGPSSLSRFYYDSSTRTCLPFIYSGANGNMNNFVSKDECESTCPVLQNPCSDDQGPPATDDNGQYIFCASRADNTCPSGYFCHYGEFLSESICCPDDDEDLCSKPLKEGVGDKELIRWYFDSNLRRCSKFKYSGKGGNSNNFITLQECQMTCKEYQNPCSDGDPALSPSGEIIFCSSGTNSTCPSNYFCHHGAIDITTVCCPLQQQSDPCYGPLSIGNGLSKLSRWYFNHHTRQCLQFTYTGMNGNANNYLTEEECSNSCPVVVNPCPGIDRIYPKAFGESLKCSSDTAFLCPIGYWCHLGSTPETTLCCPNAQDPCKQELELGIRFKTENVKRWYYDSNSKECKTFVFRGLKGNQNNFLTKDDCIKTCPSFTNVCQVQEPYRDKIYKKIVNCDNSKDCPSGYFCHRGSSSKYIKEKNTNNVCCRSLKHPCQDEVIIGNGKYSLPRWYFNTQKKQCMEFTYSGSGGSSNNFVSKEECAEVCLHDNTNPCRNGEPYKNIYGDIEHCSPQSSIHTCPPNFFCHVGEDKDNTVCCPTTNPSPCQENMEIGYGDKQLSRYYYNYHLKECLPFIYTGMGGNSNNFISKEDCTLNCNNNYPPSSRILFSTSEWPWYTENKKVKKRSISMNCGVPQAKNCKGSPIGYYYDSMSQECVPIRPCPGESLDNIFWNINECTNICRDISNERSTIDKEEDYLLIRSLGFLSQLLTNSRDKGNLRDAQTRNTSKVNISPSSPIFDTHSFIFNNLIGNTTYRVSVEAFTLTNWNESRSIWYASKLIHTPLTLLKWLPPPIELGVTERGQDFLEFQWRLPTVAITSYENMINQHELTVYEYNPITKFSSKLQIISVRLPSTRIIIDRLLPSTIYNISIRTGTDYGYGYSTWGLFATSGIYMDDGDVLRLKERTPNSLIITWDKNWMPKNPNNKEGSRYTVRAVTIYSMSGSNKELSISNVFDGHRPQPEVLLKGLSPGTTFNVTLYARIYPDDVYSKSNTGINSGTNKLNGDRIKFKRKTIEYKKTWNLFSTLPQGAYLVSDPRIAAETETAASLVWHPIEHTDVIVYYQIRYFLTESKETTMIVTQPLSEKEVLCPKYGCDWLCYLVFNLKKHPRHYEFHIRARIDNMWNKWIVVTRKTWNLMERVCSITPPNFFVDNLDSPEYMREIDIDEKEYKRVGTWRYLVIVDKGVTVSSGLDGITSIDMTHLTDLPTAKHDDISYYIAGSLTEDNLKKMKRFIIGDGKQYGGYMNYPLDDRDNDPFWTIMPISQTENEVMEPKLKSCGINEKGIVECEMSFIEMISIIPPWLFTTCVILILVIITATTFIIWRCLKSKEYSKKSSRKVSVSTYKRAPSVTYSRTASIHNISRTFVPQQVPYNNVDYTSMQLLNERDNDINSILDFEKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Q0</accession>
    <name>A0A0N5C7Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0001396100.1">
        <property type="protein sequence ID" value="SPAL_0001396100.1"/>
        <property type="gene ID" value="SPAL_0001396100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001396100.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14655" checksum="DFC83E9755AA3DED" modified="2015-12-09" version="1">MRYFIIVVCCFVVFLLAFVIPVIEKIFKYRSLEYRKKQRYKCLQCKLMGPEYLKEMEEEDIKNVDCCFICYPTVPPCKHNEISLNEFINEYTKRKDDNTKLINKKDISITIPSNGFEKEQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8C1</accession>
    <name>A0A0N5C8C1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Foie-gras_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8C1"/>
    <dbReference type="STRING" id="174720.A0A0N5C8C1"/>
    <dbReference type="WBParaSite" id="SPAL_0001417200.1">
        <property type="protein sequence ID" value="SPAL_0001417200.1"/>
        <property type="gene ID" value="SPAL_0001417200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001417200.1"/>
        </source>
    </evidence>
    <sequence length="1208" mass="140675" checksum="F86F9BAE3E617708" modified="2015-12-09" version="1">MDEPHFLNIQRSYQILFSYAGAEESKEYIGNKITGDEHVYSLSWRRDSKQYPYPFQIKFTTRFEKYNEHKALDPKDEEIKHFKKIPFLHIFFINCSTAEEYRSKIRHEVSEWFANLNNIEKSQWIIVFDSKNAREKKNRGQVMERIKSDFSSYFSRVIEVYDRASLSVLESTITASILVSIETYATMLESFLFYEKQHFTNTNFNLLAYSNGFFILMHFYWSIGLLETVLSQLDDQKMFLDDIVESYSKNCNTYEWGKRNEVFDQFELLSTLMDSKQIINFNSLAIIPYLRKYILAQQIMTSFAIYFNKSKKAINSDVNENLERLAILKIDISSIILNSLYETIQKIKSDINLLSLRIDPFVYNIWIVLIVLECFEFASILTPQMFSSDLGSNNICLLLKIKCDSMKFSWEEMKKRSFKLSKEELKKLPIHGPFFGNEINLLSKFRDCLTNSEDFQLYMESSFVEAIVEMKKLKYFRNSIYISYRLAEIYKEMDNFEGALKVKVENVKDILFAGECHGAMTKLLIREVVQEIIHFPDKDFYIKELYLFCYYGLNYASNDEGRELYQNLLFKLPLNEIVDKVEIPSWLKNQIPFQISYNGMNNHLIKCTTDKEEEFIFSISTTLPLEIIDFKVKIYFRFVNREILASLAKKRLLFMCKFNSEEMVNRFGCLHKGGSPEIEHKNDNNLVAFDSTSLENNEGKLLPKVVNKFSALLKFSQTGLFMFEYVEIILKGSLKFIVKNNLSYQGTNESQLFKPLFKNVFVIVDNDPPAIVFEEEFENNSNYLLLAGVVQTIHITLSAGSKNLDESILSIEPKSGSDDRLEFMGSDGKWSNKVCVNVKKLNAREKVKIEIHLYLPTARLSFSNWEDPPVTKKILFKWMESNSTMKIDFKPLINIITTTSIMDNKALFEMEIYRKHGKDLIIQPIDAQFQHLLKDGDMDTKDFKIDINRLNVDIIENLDINSVYSIVWLLTNHQKRIIAALNPILKYKLIFKYKVLTFDISEKKYIEIPFERGYQLISEFNFAFPAIEYEICAQLLSEQPQSVICRALSTCEMVLSIRSITRVVETIIVGLDADPGIWKINNKYKQLTIKESGLGQITFPIIPLVVGFLPYPNITIFSFNKDHGQPEKMKESVDNYPQVIGKQLCTFSRTKGKQIHVLGQITMENASSTSSLPILNHKNHNRGESNVSSSRSSLRSSARQKLQKFFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8T3</accession>
    <name>A0A0N5C8T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8T3"/>
    <dbReference type="STRING" id="174720.A0A0N5C8T3"/>
    <dbReference type="WBParaSite" id="SPAL_0001432000.1">
        <property type="protein sequence ID" value="SPAL_0001432000.1"/>
        <property type="gene ID" value="SPAL_0001432000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001432000.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25034" checksum="7520436A8B348099" modified="2015-12-09" version="1">MKLAFCLPKFVLYNIDQNNINSTNNNSNIFLQSNLDLYKMKVIQNLFSVYNISYEIKGVVVDTPEYNEICKKSGASKFPILQVDQIYFPSFSAICRHLAARFGLHGSTLTEETYCDVMSSMLFDIISIIERGADSGSVREQDDAMHEAVEHVNTILGPYIIHYIKNLRGESLTHTDYLFGKDPIWIDFALQELILLVNNFGKGRVYLTSSVKTFAETGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8V4</accession>
    <name>A0A0N5C8V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8V4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8V4"/>
    <dbReference type="WBParaSite" id="SPAL_0001433900.1">
        <property type="protein sequence ID" value="SPAL_0001433900.1"/>
        <property type="gene ID" value="SPAL_0001433900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895801" evidence="2">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001433900.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54170" checksum="416E9116B08B65D1" modified="2015-12-09" version="1">MNILLILIVFIQIITSKVDADNRCTDLYNYCPSWYSTITFILSDETNEEEWNKIKVKTNQIYDNCTTQKINMNFFAKNAAKGSCFGQQDCNMLLNNLTLNDVKPSITFNNFWDDLMHLYTKNYNSSSGLAGYIITNIECDSWSGTSMESLINSSKIIYDGIQEYNVIFNIIQIMDDEANRKCDFASILKEPSTSMNIMTVNYDNLNSVNSSLYGLCSGGYNHYKLDNWPEQIVCTSNENDFQNCRNWTYTFYVALSSDSTNDTLEKTKDLLLKLTDPCNIPGSHVYLWTSQTTNKGIPCDPSLGTNCKEAIDGLNLYDMMYSNKSSRQLDILSMKVARWSMNNPIGEGIALYIISNLKENEFYDSQIADVFLKDSWDQGYFYYTNHVVARFIDIGKVIEKRNNTKSLLTIKNASNFYFDVVSVDDLDDLISKSGNMTVCKAKYKKNISSMPVSMSLTSNLIFIILSFCYLKVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C911</accession>
    <name>A0A0N5C911_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C911"/>
    <dbReference type="WBParaSite" id="SPAL_0001439400.1">
        <property type="protein sequence ID" value="SPAL_0001439400.1"/>
        <property type="gene ID" value="SPAL_0001439400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895564" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001439400.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8338" checksum="AB7FB09FB2A18DFA" modified="2015-12-09" version="1">MNYIIFILSTVLIVVNIVNSVPQFYGPPRFGYGGYGGYGPRWGHHYHHMPPPPPPMMGPPPIVRTTVVKTITTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C916</accession>
    <name>A0A0N5C916_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C916"/>
    <dbReference type="STRING" id="174720.A0A0N5C916"/>
    <dbReference type="WBParaSite" id="SPAL_0001439900.1">
        <property type="protein sequence ID" value="SPAL_0001439900.1"/>
        <property type="gene ID" value="SPAL_0001439900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098687">
        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF17">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="160"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001439900.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33363" checksum="941631AF1227441E" modified="2015-12-09" version="1">MFANYPRQSPNPSNYFRGYPSMGFNINAASFIPQGTISNSQYSNQPVTYLQSEGPAQMRKLFIGGLNHETTDEQLREYYSQWGNVVDCIVIRDPATKHSRGFGFVTYQTIQMAEIAMNERPHTINGKVVDPKRAIPREQMLPLTSTNPPHFLECAPSTGCKITISGIHWDFHTVDGIRTYFDRFGAVEQVEILGNPRGMGFVVFEEKESADKALEYEDEHIINGKRVEIKRDEDDPEATPKTSPTKHAVKPIFPNNKNSKNMTHSNNNNDIKDSSDYSDDCSSDNTISTSHSQSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9C3</accession>
    <name>A0A0N5C9C3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C9C3"/>
    <dbReference type="WBParaSite" id="SPAL_0001450600.1">
        <property type="protein sequence ID" value="SPAL_0001450600.1"/>
        <property type="gene ID" value="SPAL_0001450600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000058">
        <property type="entry name" value="CUB domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="835"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1319"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001450600.1"/>
        </source>
    </evidence>
    <sequence length="1481" mass="171461" checksum="3E0D40304BABD1A4" modified="2015-12-09" version="1">MNYSLTNNKKTKTLSLDDPDLPDWEECQTEIYNLLQNITDPEVRDMMANKISTLKFLHEMQFIEEVDEVVNNYFNDSQYEMMTLGSQESDSSDIPIVDENEKSYLMADSVNTFNLPDIMESIRTRFGYDENSMVYNDTSHNYMFNEFTLNSMDLPSDSDNKCRGHSPDEYSPINRKPVKKVKFVDVEESSNNSQYSNENEYKGDGELFLQDVDNCTLFQTQAAFITNFNKNNTEETEDINIFATQMPIDNTKFITASQFPVPNKNSASFKIPLLPGIGTIRKKPIIPKETFAARTSLTVFESAIERTNKGTDFIRREIKRAEEDDCNFFESDHTSSSKKSSPMDCYEMKENIDVIREEIMKPNKEDNLNKQGNDIFISRSALLQVEENEFCYDIGDVDNSSQLTGEEIPMRYAKSCLVISKSKIPSTDRLYIKENEEAFPLTFCESQHIDRIPCQTERLSVTVSEMASLNINERKDHFYDFCNLIKKVKSTVKIIKTFKEQNYFDLNKFDGFGLTPLHYAVLTNKVSIVKWLIEECNHYINPHGGYDAKTPLHLAVAYKRISIIKELCTKIGIDVDAKDIFGCTPIDYCLDDEKIQNLLFNSKRKSFIKNNYFKFIPKILVDTSINFESLKKWKQTPSRELYEVFSLSKLTTHWITKSLALDMIKESDALYEAIIRRIYILHENTLKIILENKSMDKFNVEENRYIYFKGILLENGKYENSNLKEGPKTKLAMKPNLFRGCFFYVDKNGVEDQLREKLKKWIVLGEGELLKDKVSVECVLENRRDVVPFYINMNNGNSYDDKLSPSHPINTFIITDKEPEDWMEILRKKNVLIKTSEFIKRCIQKLTSPSFPQPSLPRTCTIYQIKAPDNYSIKLYFSYFSFLSRSPKCTDFLRIYTTINTTEISTDTQAYSEYCSNEISSNVTFISKYNYMYILFLSETGKSHGFVGHYSFLNNYDYKQNALQYGDYEFETYSLKGNLFSPNAPYYPPNDILAYYFIPAMDGRRLMINITFFDFPNDSCNTDYLLVKKLKSKEVIEKICSGSKYPLYYISSVGFEIDYKTGKNTLNILGFSLTFDHQQSNFDNINKYLSSSQESHNNSLDIDEGSNNFPSIDNIVWYELTKLSSLLKIDIQAIAPQSQFLFPIISNLSNEKSNRACPIKIISSKASNEVKKKENNQEIVYKEGVFDSQVHGLSNQKCHILFIGAVGEYVQLTFTKFNLEVGLNDFNGNETKGCQDQDHIVVHVLIGSRMSKINDFCESQEPPQLMSPKNIITIEYIPRESDVLRSQMPNHGFQLKYRFLNDFTETLEMNAIKDTSKSCAFIFNMSNAESGTMMSVNYPGYYPRNLECEYIFIAKDGYVVAINFDYFDVEGFAGCEDSTQSDYVLFSNYKTIDRTNRRFCGKTKPTSVIVSESNYFRMLFKTNYIFDATGFYAHYQFLNTQESNTRIKFSVPVISNSNSYNVYNIVITFIFFIKFLLFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9F7</accession>
    <name>A0A0N5C9F7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9F7"/>
    <dbReference type="STRING" id="174720.A0A0N5C9F7"/>
    <dbReference type="WBParaSite" id="SPAL_0001454000.1">
        <property type="protein sequence ID" value="SPAL_0001454000.1"/>
        <property type="gene ID" value="SPAL_0001454000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="177"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001454000.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31943" checksum="DAFDB5E2C719D131" modified="2015-12-09" version="1">MIVLTFYHYCSCVILITFTSYFLPIEGCFPIGVDVPPNGNFLPISTSSSYRAQSTIIANCKKLGCIDGFKCTNSGNCVLNSLKIKTLDDNTRNDIDNSLNTFTDILTPMKKKSGKIIIKLPESIRKEDFIEGTIKGSENSIINEMPVEVTTKSRNILMAKNYRPSSRLTADFVFKQCCLDRNIPDDCKRKCTYENYTKEAIMQMYLGRDNCPISYARELHFCAAQGTDHSECCKRRGVNTTPAGDKCLIFCDQRPGSVAMLDASYLHCYIQFENIKSCFSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Q5</accession>
    <name>A0A0N5C9Q5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Q5"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Q5"/>
    <dbReference type="WBParaSite" id="SPAL_0001463400.2">
        <property type="protein sequence ID" value="SPAL_0001463400.2"/>
        <property type="gene ID" value="SPAL_0001463400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001463400.2"/>
        </source>
    </evidence>
    <sequence length="985" mass="114984" checksum="37A936AB634319EE" modified="2015-12-09" version="1">MSYDSDDNCLVIDEDRSDNETNDLTYQNTIMDSIPKSGENEIMNENNSYNSNISLNNERIHRENEEGIENENKNLENILTMKGNDNGDNLRVNLNESESCGGIDDNEDHQNDGEYCEDEIIDESEILGDVKIQKSEINMELENAKDFGKYLKFNKSNSFYIDNNKEVIGGNDKYIYNDDSTTETNINKNKIQRENECDDDEGECEDMEEGEIVDDEVTPEEAKILQLREIKKKDFSIWNDIARQGNQNYNGYMNNYDMFEEYADPYDPEGLEDSLKYGGMYDESMDDMTLGDRPRHGRAPLQRNREKGRLICKFFREGYCRDSKNCMYSHNAKDSGRTDKLCRFYQRGNCQNGLSCKNLHGEYPCYRYHIQNACSHGDRCKYSHEPLNEYTESLLGTHGVAADDPNNSSGKKKKTLLAKDGTPLVNLPTFTEIMEQLNKEDSRTEDVDMRPFLSEDFHKGTYDVPIELKSFFNQGAGALSAQDLEAYGIATTTSIKVESPKKKPEINDYMLDLSSVDDGLTASDRILKAFQATDSEEERERAENERKEREERESRRKRKRDDYYGSRGHSNEGGKAFSRRDDRYSNRGKGYHSRSPRKDDYPGRGRNYERNYFSPRKGQSPRDYPSPRRHGSPPRYNPPRSYDTLREYLSPRRRSPPRQPSPRRYDVPNRQPSPGRYHSPERRYQSSGYASPKSYGDQREYEGGIRDYGIARNHGIPREGGYRESFGSPSRYNQEGGYKDDRYQRDTRDIRGSRDPRRDYRDSRDSREIKDPREMRDPREIRDPREIRDPREIRDPREIRDPREMRDSREIRDIRDPRGVRDSLNRQSNNNVYGEYDNRYDDGRYDMSPRERHFDNRISPRRDFEPLQTTNESTVIRTGTSYYDPTRDPRRRKLIDETSPALKIQPDGNKNENDFDQHEQNMVIRDGPYANPATDPRRNKKSLNVEEKDIGDKVTWGGYNPQPSRNPYDDPPMYVPGPPQSGYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA00</accession>
    <name>A0A0N5CA00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA00"/>
    <dbReference type="WBParaSite" id="SPAL_0001472600.1">
        <property type="protein sequence ID" value="SPAL_0001472600.1"/>
        <property type="gene ID" value="SPAL_0001472600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007026">
        <property type="entry name" value="CC_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04942">
        <property type="entry name" value="CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895834" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CC" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001472600.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10570" checksum="49C9BC65DA87C41A" modified="2015-12-09" version="1">MSMFSITITFISFLICIIYGDFISNMSNNNISIGPCLDGMCMEGYECKDDQCYQLPSTNTTTTITKNTPMNKTIGPCINGDCPNGFVCINDSCYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA82</accession>
    <name>A0A0N5CA82_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA82"/>
    <dbReference type="STRING" id="174720.A0A0N5CA82"/>
    <dbReference type="WBParaSite" id="SPAL_0001480600.1">
        <property type="protein sequence ID" value="SPAL_0001480600.1"/>
        <property type="gene ID" value="SPAL_0001480600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="130"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001480600.1"/>
        </source>
    </evidence>
    <sequence length="981" mass="112114" checksum="F06E636276F2062F" modified="2015-12-09" version="1">MDEDLYDEFGNYIGPELDSDDDEDNNDQLNRQESDHSDSDNDNDGVTMEDDEHRNTSNAVVLHEDKKYYPSAVEVYGEGVEILVEEEDAQPLTEPIVKPVGQRKFKTEEYNLPNTVFKKEFLVDMMDYPELMRNVAIIGNLHHGKTTFMDCLIEQTHPDFVRADDKDTRFTDTLYIEQQRGLSIKSMPMSLIMETSRQKSYLLNIIDTPGHMNFSDEVTAALRVADGVVVVIDAHEGVMMNTERLLKHAVLEKLPITVCINKIDRFILELKLHPNDAYLKLRFILDQINTILQTFSNDENVQVMSPLLNNVIFASSRYNICFSTLTFSQIYAKTANVNADEFSKRLWGDIYMDPKTRKFVRKMPYPDCPRTFVQFILEPIYKIFSQVVGDVDTTLSSIMAELSIHLTKKEQKMNIRPLISLICKRFFGDFTAFVDLVVKNFKSPLKNGITKREVYYTGPAETLISNAIDKCDPKGPLIINTVKNYTTTDAINFHVFGRIFSGTLTVGQSIRILGERYSIQDEEDSRIMTVGKLYICMGRYNIEVPSVSAGNWVLIEGIDEPIMKTSTIMDINIKEELYIFRPLKFNTKSVVKLAIEPINPSELPKMLDSLRKVNKSFPLLTTRVEESGEHVLLGTGELYMDCVMHDMRKVYWEIDIKVADPVVPFCETVIETSQMKCFAETPNKRNKLTMFCEALEEGIAEDIEKEEVNIEWNKKKLGKFFEKKYNWDILASRSIWAFGPDNNGPNILCDDTLPSEVDKDLLGCVKESIVQGFQWATREGPLCEEPIRNVKFKIMDAEIAKESLYRGGGQMIPTSRRVAYSAFLMSTPRLMEPYYLVEVVAPGDCIPAVYEVLNKRRGHVTKDSPLPGSPLYVLNAYIPVIDSFGFETDLRTHTQGQSFCMSTFNHWQIVPGDPLDKSICIKPLEPLPAPFLAREFMIKTRRRKGLSEDVSVVKFFDDPMLLELAKNPEILKSYAGDFHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBH8</accession>
    <name>A0A0N5CBH8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KAP NTPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CBH8"/>
    <dbReference type="WBParaSite" id="SPAL_0001524400.2">
        <property type="protein sequence ID" value="SPAL_0001524400.2"/>
        <property type="gene ID" value="SPAL_0001524400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="4">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001524400.2"/>
        </source>
    </evidence>
    <sequence length="687" mass="78988" checksum="1044297E1503279A" modified="2015-12-09" version="1">MRQLKXXXXKQPKYRRYCGVPILVTIVFAYTFLGLACIFATKGFLEIETELEPTDVKFVISGVFFILFIMFAIYPLYVIIYHVLLNNGHRRMQKLNRRAPEIPFETLIHKMQNEVRKMSKAVLALDSFTHSQTRLVVMVDGMENNEREKIVKMLDTLTLLFGTEPKSPFVLILAVDRQVIVRAAAETIKSTRAGVDRTGHDYVKNIVTLPFYIHNQNIRKMIKDIKAKAEKGEWVNETMMRRDTLSGSRMSLTIRDTENMSRKNFVLQSDNHQNAGKFLYNDDYFSNINPNSLRRISNSTQLSGRLLRSFDVDFSWVTLSVWIGIIEQWPFRMAWLLEKGVSSSTDNVTLYDIFLKLRHRIPVKHPLAKLDKSQKNFEKVLKKSAQLTDPLTAGKIRLFIPCSCNLDPYLKKLVNVEFTSDNDDNLTEFNLAEILFNLTTQNLLKDKDYWNKQETVLTKMGCNEVVSFVEQLQLPDDRIKNISKKVYDLNLSGIVLLNFSLDELQKEMNIPVGDWGMFKLLVETLRKSTRRKVLNSMSIAAATQEVKDRINVAKQQIINEEAPESAAVQAVKVKKLIKAQSLTAEVYDELYTTPSFTAPTSPTTESFKEFSRGPMSVKSVRNEIINEEDEIDSNKSDNGSNLLKFDSGEEDEEDEHPFSYDIENINTDDDEEDKNLEEVGLLSKEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBK4</accession>
    <name>A0A0N5CBK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBK4"/>
    <dbReference type="WBParaSite" id="SPAL_0001527000.1">
        <property type="protein sequence ID" value="SPAL_0001527000.1"/>
        <property type="gene ID" value="SPAL_0001527000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001527000.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43904" checksum="65BD38A718D0C012" modified="2015-12-09" version="1">MAETEVKLNTTEEPVINNNKTIEEGTENGTIIKAPEDDNKVEVLPNDDKKDIVEEEICKKIIVEPQNKDNEEVKEDTNKEITEDSKTEPKSEDKEKVEENKVEEVVTSDKVVVVEEKKVEESKDNEIKPEPVDTEPKLEKEDMTCHEETEPTKEDVKEEKVDSDVKETPNTSDKVDVKESPLSTEKPKGRGRKGAQGTPKLKDPIATENGESIANSRPRRSTVKNVDYTGADTAAIWSALTPKGSAKKKATNAKSSTSSVKKGRGRKRKTSSDGDEDLSEELSDPEPVDKTPKKGGRGKGGQKKLKTSDDDDEDFSEVLPTSKKRGAPKDRVPLEKTEPKKRGRPSKGNVSVNGGDIKDIDTKDDEQNAVSINETNDKEEEKMDTSTNCEKTAVETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBN0</accession>
    <name>A0A0N5CBN0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBN0"/>
    <dbReference type="STRING" id="174720.A0A0N5CBN0"/>
    <dbReference type="WBParaSite" id="SPAL_0001529700.1">
        <property type="protein sequence ID" value="SPAL_0001529700.1"/>
        <property type="gene ID" value="SPAL_0001529700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529700.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20648" checksum="CEC70E17E56ED300" modified="2015-12-09" version="1">MEHLRSYVIVNSNYVIFKGDLTHLSNFYEKPFYDNNGRQFLTLEHYFQYQKAVFFNDEYNANKILNTPKAIMVKRIARNIRNYNDNQWKSMRDKVMYEGLELKFKDQELKDYLKKCYFNGDKRRRFIENSGHPYWGCNIKDLFANINSNQINGSNKLGILMDRLAERLFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDR9</accession>
    <name>A0A0N5CDR9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDR9"/>
    <dbReference type="WBParaSite" id="SPAL_0001601300.1">
        <property type="protein sequence ID" value="SPAL_0001601300.1"/>
        <property type="gene ID" value="SPAL_0001601300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895728" evidence="1">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001601300.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11852" checksum="475FF4D7FBEA6732" modified="2015-12-09" version="1">MMKNLYNLCLTLTIVSILMINQILSIDTSHLDKSSDGLNVNKKYFMPITRSRRYASPYGYDGYYGSPVYYQQPIYYTSSYYNPLSAFCLFCARPSGFSFIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEV3</accession>
    <name>A0A0N5CEV3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UMP-CMP kinase</fullName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate/cytidine monophosphate kinase</fullName>
            <shortName evidence="9">UMP/CMP kinase</shortName>
            <shortName evidence="9">UMP/CMPK</shortName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEV3"/>
    <dbReference type="STRING" id="174720.A0A0N5CEV3"/>
    <dbReference type="WBParaSite" id="SPAL_0001639000.1">
        <property type="protein sequence ID" value="SPAL_0001639000.1"/>
        <property type="gene ID" value="SPAL_0001639000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>CMP</name>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001639000.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23041" checksum="FADF3ED1AE47B9DF" modified="2015-12-09" version="1">MHFSSIFRMYNVVFVLGPPGAGKGTLCSMIQEKLGYKHLSAGELLRQERIRKESAFGEIIENHIKNGTIVPVEITCKLLKNAMAQSGSGKTFLIDGFPRNQDNLDGWEREMKDCANVQLVLNLTCPEEISVERCLGRGQGRSDDNVESLKKRIRTFHEQTLPIIEHYKKLKLVKDVPTVSAPEKVFDETKIFFDEVEHHNIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF51</accession>
    <name>A0A0N5CF51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abhydrolase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF51"/>
    <dbReference type="STRING" id="174720.A0A0N5CF51"/>
    <dbReference type="ESTHER" id="strea-a0a0n5cf51">
        <property type="family name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001648800.1">
        <property type="protein sequence ID" value="SPAL_0001648800.1"/>
        <property type="gene ID" value="SPAL_0001648800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="61"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001648800.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40609" checksum="F776E5D0F676D30F" modified="2015-12-09" version="1">MIIIFEPIFGEQINYRIFRFWASVGPKLFSKKSKHVSIENITIANVPCRIYIPKESHNKAIIYIHGGGFMTLHPENYDVPCIQISRKTQSVIVSIDYSLSPEKKFPKALDECESVIFEFCSTYYKKYGIDKNFISVMGDSAGGNLTTTVCLRLARQGISYLINKNILIYPVTSSLDYLLPSYQYYYQRCNNSGLLNPQIKANILKFYLPIKLSKSDTEKILLNGHVPHSLRNLEFTSHEILPLSWREEIKRPIKSMEPDEKLSAKLKPYLCNPDFTPIMATYQDLSKLPKTLILTCGCDVLRDEGYLYYKKLQKANVDVEWRHYEDGIHGALNIINSTVYKKIINDIVEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFF9</accession>
    <name>A0A0N5CFF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFF9"/>
    <dbReference type="STRING" id="174720.A0A0N5CFF9"/>
    <dbReference type="WBParaSite" id="SPAL_0001659600.1">
        <property type="protein sequence ID" value="SPAL_0001659600.1"/>
        <property type="gene ID" value="SPAL_0001659600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001659600.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="42267" checksum="478E4229F96C1BA1" modified="2015-12-09" version="1">MDGTSFRRGAGNDAKFTDKEKKMLNKIKFEKVLETKIENWSKIDLDILRPWISKKIIEMIGVEDDIVENLIITSLQSGTDPKVLQMNLAGFFNARNARIFMGEFWNLLIEASNSKDGIPQALIELKLSQVKEKENKKENRGGEENDDWKDRYEKMSGFKHDRDRRSSRRRRSRSYERRSVERRRDDSRSPDRRDYKRKSHRHRRDSRSPRRRSSSYRRSVSPKRKSRKHSSSPRRKHSRRYSVSSERKGSYSRRRSRSSERRSSKKHSQKTKRRSSSLSISPAPEKKSSPQRQSSTSRRSSSRSLSFSSSRKGSISPEYKRRHRSPYSPRHKSRRYRKRSYSSSSSVNSKGEWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFP1</accession>
    <name>A0A0N5CFP1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFP1"/>
    <dbReference type="WBParaSite" id="SPAL_0001667575.1">
        <property type="protein sequence ID" value="SPAL_0001667575.1"/>
        <property type="gene ID" value="SPAL_0001667575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001667575.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11026" checksum="264D9B7C0C6C3099" modified="2015-12-09" version="1">MRILWRTVKERKPLTPTYRTFLRACYDIIRTNVNSISGSLPSQPSTPPIACLPEASFNHIESNNTKQYSSENEEPISFGLVEEPIFSELIEPIFPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFU9</accession>
    <name>A0A0N5CFU9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFU9"/>
    <dbReference type="STRING" id="174720.A0A0N5CFU9"/>
    <dbReference type="WBParaSite" id="SPAL_0001673200.1">
        <property type="protein sequence ID" value="SPAL_0001673200.1"/>
        <property type="gene ID" value="SPAL_0001673200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="539"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001673200.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75677" checksum="C280111122722FDE" modified="2015-12-09" version="1">MTAEFNDTFFNSLQYLSDSLNIKSEDGNEQYMELEPFFDQLTPDDLSLDTLPEEEGSHFEELPSLEDFNPKLSHSDILFNYFKEKRNNDPDGSCMDTQIRLNGVTVRRCNRLLLLAYCTRLSAPLNGLKKHSAILIDMDESMTKLNKKDLEIVLDFIYDGRIKEITSTLETSASRLGCYAIVDILKNNRLSEDDLPSLVDPYHVHRFQNAVEKFKIDNILVDCTIMCGNEFIGDCHKHVLSAFSGAFENIFKVSTNNDNNIFDIKEYFPSIGAYELGTIIDYIYSGALRCIKVCKLEQIYTAANILEVDQLISQIINNYDVRVNLSYDNEAHSDSGTFKIFSSAPNNDYSMYPEDDLSNISDEYTRHRESSLPLNMDNREAYVEIYCEYVKGPQGGRKTGTYGINKSRFRENEDNKLAKNAEEVLTTAQQKLNSVSHYVYRGPKLSNELNNSNDLPLSTDIEMDGRKISLYTTKKNTHSQDIPISELPTLKPNTFNKNTPQQPSSFFNSCLSPSPPSITKSTTPLPMTIPPSDYDVRPYTCQYCSYRAKEKSAIDKHVRCIHTKEAPYICNYCDQRFKVQSNLVRHIRSHTGEKPYACKKCGTAYADKKNMDAHVFREHLKIPPRKCPVKGCKAKFYRVDRLDIHCRKKHGLDCITEYNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHH4</accession>
    <name>A0A0N5CHH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHH4"/>
    <dbReference type="WBParaSite" id="SPAL_0001729100.1">
        <property type="protein sequence ID" value="SPAL_0001729100.1"/>
        <property type="gene ID" value="SPAL_0001729100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001729100.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13700" checksum="52C2E07018FEC0C7" modified="2015-12-09" version="1">MKLNNNILVGKKSQIRLKDLVLQICLMFLVIAGNIVVFLYQKGICRPGVQFLFRIFYKLDSLLRKEASEMDCQHSGVVFFSTPINPASKTLRRNFIGNGISPIVDKRDNSWTHSNVTGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHJ5</accession>
    <name>A0A0N5CHJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001730900.1">
        <property type="protein sequence ID" value="SPAL_0001730900.1"/>
        <property type="gene ID" value="SPAL_0001730900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001730900.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34342" checksum="C3C6390BD393C058" modified="2015-12-09" version="1">MGGTSSKETKETINIINDNMQAQGRNTMDSSDHMKHIYYGETLSLVTKIFAIVGLIGTIIFIIRCCIAYHKLQRRSSRSNHSKKDINTNKQLNENIIRKIEETDYNVYRLSESLEEMKIKLDYLFEIQLSNKNIRKTHSKTLYHLSGTIPRLLMEASNEELKDMVHQMRERCFGVDGKDRIENMKLRKFLVDNTIKRKALELIQNEGKFCKFVADILIPNSQILKFYFPSQYTRRNKDQLFGQDTVKEFMITAKYLGAGIISEFKQSAKDTIYCRSAGDLKSAEHWVVRTILRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHR2</accession>
    <name>A0A0N5CHR2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHR2"/>
    <dbReference type="STRING" id="174720.A0A0N5CHR2"/>
    <dbReference type="WBParaSite" id="SPAL_0001737600.1">
        <property type="protein sequence ID" value="SPAL_0001737600.1"/>
        <property type="gene ID" value="SPAL_0001737600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002372">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004752">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="36"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001737600.1"/>
        </source>
    </evidence>
    <sequence length="748" mass="84455" checksum="543A9164481C6451" modified="2015-12-09" version="1">MRFVSLTQRNFLRQFSKTCRDYSSEPVQLKKIMPNERIRNIGISAHIDSGKTTVTERILFYAGRIDSMHEVKGKDDVGATMDFMELERQRGITIQSAATYVDWKGVNINIIDTPGHVDFTVEVERALRVLDGAVLVLCGVGGVQSQTFTVNRQLSRYNVPFLTFVNKLDRTGATPWKALDGLRGKLNHNAAFLQMPIGLESKFKGVVDLITQEAIYYEGEDGLIVRRDEIPKECKAQALDLRQEMIEHLANCDDKIGDQFLNDINPTEDEIHEAIRRNTISRKFVPVLMGTALKNKGVQTMVDSVVKYLPDPSEVVNKANVKRDNGEEEKIILNPIRSVQKSKENPFVGLAFKLEAGKYGQLTYFRVYQGQISRGDMMYATRDNRKVRVQRLVRMHANDMEDIETAYAGDICAIFGVDCASGETFCSDENLNVHCESMHIPEPVISMSIKPINKKDADNFIKALTRFTKEDPTFKRDYNAEHKETVVSGMGELHLEIYAQRMKNEFNCPVELGKPTVAYRECIASPYKFHFRHKKQTGGQGQFGEIEGVIEQLPPEQNTNVEFTDRTFGNNIPKSLFPALKKGLDQIILEGPLIKSKVAGINVIITDGQTHAVDSTEIAMINTMMNMMREAYEKGHWMLLEPIMKIDVVVPSDFQGTVVTSLTQRNALITTTNTSDGFTTITCEAPLSDMFGYTSKLRSLTEGKGEFTMEYSKYAPTTVESQEKIIREWKIANGLIDPNAEKGKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHW3</accession>
    <name>A0A0N5CHW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G2/mitotic-specific cyclin-B3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHW3"/>
    <dbReference type="STRING" id="174720.A0A0N5CHW3"/>
    <dbReference type="WBParaSite" id="SPAL_0001742500.1">
        <property type="protein sequence ID" value="SPAL_0001742500.1"/>
        <property type="gene ID" value="SPAL_0001742500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="256"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="260"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001742500.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44864" checksum="3F8FDF3DF9831692" modified="2015-12-09" version="1">MMLRSRSNAVNGQQDGTTNSQETKGLGDKKRHATKEDLGLEPKPKRSALNDLSKAISNVVLDSNKKDSLQKPDLKRAIRATNLQTITEAFKSSRNNSVKAVKEPPTTYDFDRECSKDLTANATFANDIFNYLKSREPMFKIGDYMKKHKCISHEMRGILGDWMIEVQESFELYHETLYLAVKLTDLYLDRVESVRQEDLQLIGSAAIFIASKFDERSPPLIEDFLYVCNDSFSRDDLIEMEMKFLRVVGFEALTAPLSYRFLRRYSRVIKGDMATLTAARYVLETSLLWFDFSRVSESKMAAASLLWALRVKKVGDWNPVLVKYSGYRLDEIEPLMYALNHMIHVRPKHLRKFTTVYEKYSHEVFYKSSLLTPLPDIYKSTDPIKVPPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI17</accession>
    <name>A0A0N5CI17_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5CI17"/>
    <dbReference type="WBParaSite" id="SPAL_0001747900.1">
        <property type="protein sequence ID" value="SPAL_0001747900.1"/>
        <property type="gene ID" value="SPAL_0001747900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="278"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001747900.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43707" checksum="4E75CCF953148C16" modified="2015-12-09" version="1">XKHTEAFENLKQAIISACTLAPPDPTKQFTIMTDASIQGLGAALMQEDRPIAFASRTLKKSETMYAPVQLEALGLVYALKQFSPYIYGKRSVVLTDQNSLLSLMTKKDVSNILDRYKNYIMGFDLDIKYIKGSNNIVADYLSRKVFNINLTDTLESYTDVFPKVTTYLQYPFTLENFHKYLNEKEKDTYPDCKTSLRGKTRLYVPQKLRFMVLTRWHEHPLLGNHNGYDKGAPKFKDTFHWPAIDNDIKRIWSSCTTCLTNKPHGPLQATVHDKKIPIPPYPWHTLSVDHLVISEHNYVLVIIDEYSRFVHLHHTTNMGTSTTIKLLKLSFFLLGFPHTLKTDNGPAFIADLFKNFCKTYTENFFKHTYFLCLNTIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI32</accession>
    <name>A0A0N5CI32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI32"/>
    <dbReference type="WBParaSite" id="SPAL_0001749300.1">
        <property type="protein sequence ID" value="SPAL_0001749300.1"/>
        <property type="gene ID" value="SPAL_0001749300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001749300.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36094" checksum="D6DA16CC3409916F" modified="2015-12-09" version="1">MHSDSFSKSFRIAYLAFGFIFEILYIPSLIAMLNSELIHLSCYKIMFFIGVLDFFVIIINAIFSGYLGYIGAVACNYPLENYILGVLALMGWIMTSTSCLLLAINRVIDVFNSYLAHLLFDGYKTYAWLLIPTIYGLAAGVFSNPPGFTSKQMAWFYDPHYGSNVPSDLPVPNYINYVQVVHNLFVTSVMSIVYIVFCGLIALKYKTTHKIKLTDAKGSLFIQSFIICFSSFAAAAINVYMQFFQTPDFVVIIGHFLWIFTHGFTSVILIVFNKTVRGIIKTLYLRMMGGNDGKMTINDTFSSFQSIFVISMTYVVAGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIG5</accession>
    <name>A0A0N5CIG5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIG5"/>
    <dbReference type="WBParaSite" id="SPAL_0001762100.1">
        <property type="protein sequence ID" value="SPAL_0001762100.1"/>
        <property type="gene ID" value="SPAL_0001762100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895922" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001762100.1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5930" checksum="7B182414496EBE85" modified="2015-12-09" version="1">MNKYFILAILILSSFGVMGARIFKTNKINYDFQDDTETDVKDIKKRGYYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIU0</accession>
    <name>A0A0N5CIU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIU0"/>
    <dbReference type="WBParaSite" id="SPAL_0001774500.1">
        <property type="protein sequence ID" value="SPAL_0001774500.1"/>
        <property type="gene ID" value="SPAL_0001774500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001774500.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9227" checksum="432668542FD54C02" modified="2015-12-09" version="1">MIFIIFTSNNPQTNANIFGKLPIFPITSHSGPIRVNEIDGKILDYPKSRSKRWSNNYMGGNFDWNGLLIRSGVFSDYDKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1V4</accession>
    <name>A0A0N5B1V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">snRNA-activating protein complex subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1V4"/>
    <dbReference type="STRING" id="174720.A0A0N5B1V4"/>
    <dbReference type="WBParaSite" id="SPAL_0000005500.1">
        <property type="protein sequence ID" value="SPAL_0000005500.1"/>
        <property type="gene ID" value="SPAL_0000005500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="451"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000005500.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="102932" checksum="2A00159E8F207494" modified="2015-12-09" version="1">MDEIDPYSEDFLLGSGYDNLEQDSIYSNDFTIPTTSTITKSQLPVNEFPGTPRQLESNSLEDGREMSEEERQLTILIALNKAYQVTTDKAIQQVEKEISIIRRKYQTLKNKVYRINAKSEYMETLESKHREYAVFEAPYFMDDKGSYPRRGEEGKLFDELNPFKNVRNFDFEQECSVDWTENEYKILRNAVKDEIVRIINGPAVNYRDKLVYDLKNADSSSTTPDELDTKKVELENIERRINYQKNLKESEIFQQETPDKIAKIDWLTISAKEFNGVRSADDCRRMWINYLSPKIYKGEWTKEEIKKVVEYGSQEWNDWEKVALLVGTDRSPYMYFEKYIECKASSIDKIPFSLEEDKILVKLVKIHSFDGVIFWDKIASALSGRSITTVKNRYERALCPTIRKGKWTEEEDIRLIHAIKVMGPMDWKSISSYVGNRTDSACRDRYLNALCNEVKVEPWTMEEDEIIMLGAELFGYNNFKAIATLLPGRSREATKGRIRRYIRQYESVNRGTKRKRDGTVYKLGFTPSKSSDEKDYHRRLLAKYADIFVSSNYSLQSDKKSLFEINPEVDFKPGDRPEITTSRGRFFAAKKGVNILEVKWEENPFVKDLDKEQEEYGRSEIERIRTLYSNLTESEETDEEKRERVSNFCRRINRVMEKIKPSDKDTIIRTETVSVAVPEKKEKLDPSTHGLNPKWFHWNMGKVEKEIQDLSIDDGKIFYMKVICEAICKQHLKIFNKNLSAYIKEIDGSVVLSQYIQERLLENVNNSLKFVEGGNAISTFGLTGKDILIPPSIKTLTVIPLLRIKNKFNDSVCKKLYSNHSNQKGDKKKAVIECGLPKLEPLGFELSEKVKKSDQYKKLKMRLFSLLFVPFLYERAVNKNCLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Y0</accession>
    <name>A0A0N5B1Y0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acidic leucine-rich nuclear phosphoprotein 32-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Y0"/>
    <dbReference type="WBParaSite" id="SPAL_0000008200.1">
        <property type="protein sequence ID" value="SPAL_0000008200.1"/>
        <property type="gene ID" value="SPAL_0000008200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000008200.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13802" checksum="362FB775349A92B8" modified="2015-12-09" version="1">MRPRPPSRRVTIGRQRTTPRRPGGRGSDPSRPRDNVPPEDGEEGEEGEGEDGEEEGENGEEEGENGEDEGEKGEDAGENGEDEGENGEEEGENGEEEGENEEGQDVEEEEEEEEEADDQTQDEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B449</accession>
    <name>A0A0N5B449_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mcm10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B449"/>
    <dbReference type="STRING" id="174720.A0A0N5B449"/>
    <dbReference type="WBParaSite" id="SPAL_0000085100.1">
        <property type="protein sequence ID" value="SPAL_0000085100.1"/>
        <property type="gene ID" value="SPAL_0000085100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000085100.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23740" checksum="64D129EC260D883D" modified="2015-12-09" version="1">MSRKPLTPAQLVALMNADKEKEIESRKRPSTTTTNICTSKPKAPRPTLLGGKEFSNDEIRAMLNKKSVREDEIKAFEKEREERYFNIMEMREKVEEAVTSLMEIKNVKIFVCTVCKIKYHRKNPICVEKRHLIKEELGTRRFFKCSDCSRRCITYFVYPRTFCSNCKGRNFIRVSMKDERIVKDREELLVRGREEKFINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B485</accession>
    <name>A0A0N5B485_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B485"/>
    <dbReference type="WBParaSite" id="SPAL_0000088800.1">
        <property type="protein sequence ID" value="SPAL_0000088800.1"/>
        <property type="gene ID" value="SPAL_0000088800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000088800.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31066" checksum="8CBB7474633333EA" modified="2015-12-09" version="1">MNDKIEINWSERPFHYVLNKLLTKIEECANTLVKRKTIEKDNENRRRKNVNANDLEDGSNLCHYGFYMKHLKKLLEEIYTNKIDFSYYHYLQNKKKLLRLRRDVQEYRVVHEDDPSKFDSWISIDFIGKSSRANTVHIINLTTSQIFLKPLLKLKSKFVKKCFKGDLPPTTIEDMQIETEMEKKTEDFVDPILSKLAISDIPEFIGLNVMGYTIRHALIRSGNKLRRTSFMSLTVASDIGAVSRGHLAAIADRICNILRSRPELPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4D4</accession>
    <name>A0A0N5B4D4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with lab-1; the interaction is direct. Interacts with knl-1; the interaction is direct.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4D4"/>
    <dbReference type="STRING" id="174720.A0A0N5B4D4"/>
    <dbReference type="WBParaSite" id="SPAL_0000093600.1">
        <property type="protein sequence ID" value="SPAL_0000093600.1"/>
        <property type="gene ID" value="SPAL_0000093600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="13">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000093600.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37324" checksum="25B9C3F478D3A082" modified="2015-12-09" version="1">MEELKIDAILNRFLENRGTKPGKNVQLTEMEIKILCMKSREIFLSQPMLLELEAPLKICGDVHGQFYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHESAAINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAVIDEKIFCCHGGLSPDLQSLDQIKRMTRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGAEVVSKFLSKFDLDLICRAHQVVEDGYEFFAKRKLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPSDKKKGYGNINNSSRPVTPPRNATPNGKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5A5</accession>
    <name>A0A0N5B5A5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5A5"/>
    <dbReference type="WBParaSite" id="SPAL_0000125000.1">
        <property type="protein sequence ID" value="SPAL_0000125000.1"/>
        <property type="gene ID" value="SPAL_0000125000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893913" description="glucuronosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000125000.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60281" checksum="B4DEFA81B5569BFC" modified="2015-12-09" version="1">MFLNILYILCLLILPHEGYKILIFNPKLGHSHVNFFGQIADILIEAGHNVTVIVADMDLSITHPGTYKANIYHIPADPIVADLLTNKTRLHKMWETSSSTWAQIDMFNDFVKGNILSAKKIFHDNELANFVKKQKFDLAITEVFNIYMYGLFKAWDIPATVSGSAVGLMEYNYATFGIHFPSSHIPTLMQPSYDKMGYNERFSNLMSYIFTKIMNRAMSYEYSLQGEFDKKYGKDFFDPFRLIGDTSFIFLNSNPFLDIPGPKTPKMVEIAGIGIHEPKPLNEHWDKILSLRKYTVLISFGSLARSSEMPERMKNGIIETVRKLQNITFIWKYEKPEDGIPYGISNLILSKWVPQNDLLNDSRLSLFITHGGANSIAELSFRGVPAIAIPVFGDQFRNAKLIEKHETGLVMDKSLLENSNELQKNINKILNDKRYKENAYLVSQRLKKRPINSKTLLIQHIEFACQFGPLPVLDLESRNMNSIVYFNLDIIFPIIIFFTIFLYFIFFSIVKIVRTVFVKKIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5D2</accession>
    <name>A0A0N5B5D2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5D2"/>
    <dbReference type="WBParaSite" id="SPAL_0000127500.1">
        <property type="protein sequence ID" value="SPAL_0000127500.1"/>
        <property type="gene ID" value="SPAL_0000127500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000127500.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39690" checksum="798AFEF9A322C0C6" modified="2015-12-09" version="1">MDASTEARYDTGSKFYDLPNDVLLCVFSKSNLKDLLNFKKACRKFYKLIDDNYIRMSKTVAFEMSITRSPLDDDKISFDLDVCYVSHNKNNRSSNGKYFKRGIKGEEEFSKTLKIFVTKSLYRLVVRNCDNINVFNVLHKHYQQESSIEILYIDKLGENDIQPFQQFVNQLENVKMLEVLQIFSSIEACKTKPSLIFPSLTSLECVNLTECQETNFLNHKLIVELFENNPNIRDLRLSSKNIHFMESVLVWFFFRQQLTTSRTCNHNKISLCLDNISTYKEKLIRTLDTTIRYLRGILGYEILTTFKGHTKYEIVKKCFHCNEKSIDIHVTLINSTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5K6</accession>
    <name>A0A0N5B5K6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5K6"/>
    <dbReference type="STRING" id="174720.A0A0N5B5K6"/>
    <dbReference type="WBParaSite" id="SPAL_0000134825.1">
        <property type="protein sequence ID" value="SPAL_0000134825.1"/>
        <property type="gene ID" value="SPAL_0000134825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000134825.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31594" checksum="FF8A25B0F8A3E95A" modified="2015-12-09" version="1">MVFAEIEKKDKNLIIFSDLEMFEGKEKTLRDFFTFSMFKDTTKATKNFEEKLDDVKKNVYSDLKIEQQYKNTFYEEYNLSIYLNVVIMFVKPFEIPTNILLPIVQSKKDESGYHQMVKKATFAARGKLENFLNFNINQLYKDLGNSKIENKMKLTRFLSPPYSKYDWDLNKEVTALIGEYIGIHAHNIILKMFINCYNCCNDFKVTIIGKHILQCSPMNIRCPIPGCTTVEFTHRKRFMEHFNRNHWKQVKDSESSCFYNNNRYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6L7</accession>
    <name>A0A0N5B6L7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6L7"/>
    <dbReference type="WBParaSite" id="SPAL_0000170500.1">
        <property type="protein sequence ID" value="SPAL_0000170500.1"/>
        <property type="gene ID" value="SPAL_0000170500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000170500.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38607" checksum="CB9DEDEE1BCB1D9A" modified="2015-12-09" version="1">MPFPIEEKLLLSFEIFSFTLYFIIIIYLNLHYKKNKEFFSLPFIIQFTFNGICDLVSASSVIFFRKIAIWGWLRDYFEENDWVTILYRLVFYQFTSLTITGNFLITLNRYMTMANPIFYKNKWTPNFAICIVILQILVCFGIFSHLYFVDAVFVYDASIPTWYFTKSKWIYSLFDSICLTSISWFSAIGTGVLNFKICLQYSKIMKSAVGSKRKNKICLFVFTLITCTFLYITAIQQTVRLKSAIDKDRRLRNLMNYYFFYMLPMLSCIHAYLMIFLSRKIREDFFSWFYRCILGREFTTVTSIGQPSKWTVPNHNVLKSFYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6T3</accession>
    <name>A0A0N5B6T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B6T3"/>
    <dbReference type="ESTHER" id="strea-a0a0n5b6t3.1">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="ESTHER" id="strea-a0a0n5b6t3.2">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="ESTHER" id="strea-a0a0n5b6t3.3">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000176900.2">
        <property type="protein sequence ID" value="SPAL_0000176900.2"/>
        <property type="gene ID" value="SPAL_0000176900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580:SF6">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580">
        <property type="entry name" value="PROTEIN CBG05369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007256262" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1747"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="573"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000176900.2"/>
        </source>
    </evidence>
    <sequence length="1781" mass="203694" checksum="7F384BF592A78268" modified="2015-12-09" version="1">MYYRCFLLFIFAGIGRCYDMLRIRNTSYGYANGISFKSPDCGSEYYAFYGVPYGELGNKRFEDASPPSKWDKIRNFTYYGPSCSWKGGINSTNRSLISQECLNLNIFTTKYCLLYGNCPVLLTFYGGETNFNETSIFNTGYTLKDFINSTDDNIVFVIGDHREGVIGNLNINSRFPNISINTNVALFDIQRALGWIKDEIKSFGGKGNDITLMGVGDSAIEVNMLRYLESSRILFNRLILIPLSSVDNWIHQNNSEEFSRRIAVMAGCANEFTDWNSFLQLEGIAGCMKFVNEIRLSEYENILTSSGYRKPLPFLDRGPNSFFKFSDNQTTIERKNLPVLVIGNIVEDRNVSSPSTCKFFVNFFQYDNNSLAYTLTNTTTTDSTDINMMDENLGLYLGSKNECLANFNSTSGSYVYQFNFQSLYSSFSKFPLLTNKSTYDIEGIFTVDRNENRQMPDVIEGMFEDALVNFINTNSFGDERDIIYNFNINLENIVIIRENDYGMIGPEIKDQTLDEQIKALINYFMDILKKYLYGEQYNEELLPLYQYGELKKLVNVTILFPPDIHINSTTIDSNGKVIGTRIFSTDGKIYGYAYRGIPYGAPPIGSLRFKAPVEPNNWDGIKDCTTLPKSCPLISNDNKDLFNLDEMSEDCLYLNVYASEECLLYGKCPVVLYIYGGRFVGGNVRKFNEQTLIENFANDNRNVVFVNFNFRSGILGYLALNQKFELPMDTNAALHDALTVLKWIQRNIKSFGGDRNDVAVMGHSSGGVIASYLYASPRTRGLINKVIIMSSVHKHVSFRDANEFYGRQTSIQAGCANYYTNWESINEIEATLNCLRNLSLVELTEYSREVEAACWWYMGPSSDYGSYSFMIYDWDLLSKLKPNIPILIGNSIHEKQSGKYLLNLDGTINLDRLKLYCNTLNSYYHFEDPQKFTEECVNEYKNDNIRILGIADELEIFLSNVLLARDAINAGSNVFLYQFTYNKSGEAVHQKSYPLSPHHSTELSYIIGWGRNIFTDKDYKIQEHHSRMFINFIKNSNPSDEEIIFNRYDLRRNNYYNVDFDDNGDIVGGMRENYNDEAINFWLKKIPFKVGSYYQRTSEEGLINILPLQNEIIHQYSLGMIMIVNWLFKTGIIITSLSLVGCSVVNDTLLNRKFIDKNDIKDVFENFLLQRQTKGKKITTENNIIGYGFFGIPYASPPTGNLRFKASGPPKKWFGVRNSTEFGKGCIWNSARTPRIPNKDTISEDCLFINILSNEKCLTKGNCSVVLYLHGGKYSYGDSNSLNSEMLIENFVSRDIVLGTINYRLGFLGFGLLNHKLTNLTMNSNVALFDVLEALKWINSEIKYFGGNPNDVTVMGHSSGAVMSNFLYYSRRTDKLVNKHIIMSGSSKDGHFIDGNEIYSRKIAIMAGCAFNTTNWELPSDVEEVLECLRGIDVQKIVDSQRIVEESGIEIFTPTYDKGFNSFLQFDFDYLVKNKPNRPLLIGNTLYEFVSGIGCSEEDSKKVTREKILVLCKHICSLFDFMNPPIAINACQEEYNEDCSKSLDMTSDVEIFLANLRQCYENYNVGADSYLYQFNYADLKMTLDADHNWLPQHASDIVYITGQHRNIFTKADYRIQERYSRIFANFIKYSDPSDNEILFEKFDPSINNYYVVDFDKNGSFSGGMVNNYRRDAVKFWNEKLVTVAGPFKSSIYEGNFVKIQPRQVIITSNATLKELIYPDSYYKASSMVTDPKTRDDLKNYPENATSSTFYVIFLISLFMILLYVINNGCRRSVPKSYQVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M4</accession>
    <name>A0A0N5B7M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7M4"/>
    <dbReference type="STRING" id="174720.A0A0N5B7M4"/>
    <dbReference type="WBParaSite" id="SPAL_0000204900.1">
        <property type="protein sequence ID" value="SPAL_0000204900.1"/>
        <property type="gene ID" value="SPAL_0000204900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="106"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000204900.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30062" checksum="C5BFCD2257057C91" modified="2015-12-09" version="1">MINYNQSQGEISECESDVDDRELLENFAGIINMDENDIPEDSDDEENESDDDEPQIKRMKIDESTVFSSDVEWKKNPSKVTSHLDSFVGETGPTSFSKNNIKCLLDTFMIFFPDEMKEKIVSCTNARASEKRKKEWMVMTISIFEKLLGIVILLGALKSAREKIRYVVQGPFSRFDKYRQYMIPAKLIVSYLANLCFENNVEEGDKFGCIRNIYQKFIAICGMAYNIGSEITVDETLIASKNRFKMRQFLKSKPAKYGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S2</accession>
    <name>A0A0N5B7S2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5B7S2"/>
    <dbReference type="WBParaSite" id="SPAL_0000209700.1">
        <property type="protein sequence ID" value="SPAL_0000209700.1"/>
        <property type="gene ID" value="SPAL_0000209700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="548"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209700.1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="182128" checksum="E2505A8FF75A6558" modified="2015-12-09" version="1">MSGSESQRTIEENLDLNVSIAAFRTLNRKRKSPLPEDKINQLAEIHCHCARVPDNKRTKLIESILEEESLLYSNELESTDLYLQASESTTIMNNMSAAPPVVTDYLKSIERFTDVRADMARWLRKFNDAITLQKIPNNDKTRVLALYVCEEISDFIYEKIDEDENITYDEICRQLKKRYNGELGQYALENKMRLFKLNPFEDNFAEKIYQYVDLVKKANRDITDEKKMLREIQRRMGDILKNYQDLWEVTIDAKNTTVTEMIEQIVIKAEMHQFRMQQRRRRTMSDPQARDRQEFKKTCYRCGKPGHLQRDCRADNPVQKKKVDEPLKQANYQNLDCAETRNLEINEDNYFVDNSYNMRSLNQNKNFKLYKGPFIIIPVTIVSKEKEKDSRGFIDTGANVSMINRRAAKELDIDIQDNERIKVTLATGVEKVMTATAVVKLRFKNGKEIQTKMLVSEEENDGYDVAIGSDILEKTSARICYNQSQKAERKEKSATTEVRKMRSEKIGKCSHKIPKFEYCSNQIPKFSRYEIQRRHHQQAQRIIDKWEEDDIIEECPWPKTLLNIHAVPKSEDKIRIVLDCRPVNTLYKPYQFPLPRTDKLLKSLKGTHFTIIDLESYFLQLEIDPTDRPYLAFKDTRGKVFQFNRIPFGLKNASSIAQTISERIIRGTQTKAYIDDFIIATSGSLQAHIDEIVEFSKKLEDLNLTANSEKCKFACTTITALGHIISDKGVVPELHLLDSWINYPIFQSYKSIRRFVGAVSWFRSSIPNLAAAIKPLTKVMNKRGNFQLTEEITKAFQTTKEAIKRTCINYHPDYNLPFILVCDASNGIIASALLQKKSDKYYPIGFFSKSIAERKKFNNIEEVVTNNPMYIPACELELKAVCESLKFFKFIIGQNKVHILTDHKPLISTIKNSSTPLMLRQLSLLQEFNFTIEYLAGVKNQLADAISRATLKKIAVNGIDPTETQKILETTTYIMEEHLPVEEFEDLLQVDVVKSDDDREIHEHDRSVRNSGLQVKKSNKDKNNPALKHDNLTDEMKVEAMKEVHDQLGHQCFEKCISLLKLRYNWRGMSNDLKSHIQKCHICLSKNEPKMIQYQYHHPIATYPMELTNLDACGPFKATERGNKHFLGLVDMLTKFIVIREVKELNSQVVIQFLEEDIICKLGKPTNIRLDNASYLKSNKIQEYLKSQGIKFSYAAPGHHQGNSSIERVFKSLHLIVARMLKEDPQIQWDLILQRAAYYYNIATHSSTQHTPFYLMYGRNPILGENDTVDKERLKNIIDYDYNLVERQINLEHARKIAMEINDDIRKKLNGIVDTKDKHLHIGQRIYIRRPDQKKERKHDSPWINNFVIVGLQDNSIRCRYWDDKNGKLKGKTRIVHLQDVKIDPNGEIMKIPDAETDPLPNDAHSNKENKRSEDNLTVKEHSEIGSEHTTSMDDRGYCNRKVKVIKKGSGQLSRWRMSGSESQRTIEENLDLNVSIAAFRTLNRKRKSPLPEDKINQLAEIHCHCARVPDNKRTKLIESILEEESLLYSNELESTDLYLQASESTTIMNNMSAAPPVVTDYLKSIERFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7V1</accession>
    <name>A0A0N5B7V1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7V1"/>
    <dbReference type="WBParaSite" id="SPAL_0000212550.1">
        <property type="protein sequence ID" value="SPAL_0000212550.1"/>
        <property type="gene ID" value="SPAL_0000212550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000212550.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19914" checksum="36237494614A9A2C" modified="2015-12-09" version="1">MKTTEADSCCFPWAWKTTKKVGITLHYDEVDAKKPRNRPASDYNSSTISSISTTVTMSNKLFLKNTDAENIDKEVFKMHPDYKSIIENIIVHLFESRVTQHLVDNTDDIIIRNYPTELKLNLIEYYRKFCAIVISRNFSTSNSYSSFLHVLKKLHGVEIDKYDFSFLRSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B810</accession>
    <name>A0A0N5B810_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1336 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B810"/>
    <dbReference type="WBParaSite" id="SPAL_0000218300.1">
        <property type="protein sequence ID" value="SPAL_0000218300.1"/>
        <property type="gene ID" value="SPAL_0000218300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000218300.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45645" checksum="41CD8ED9B6497DA9" modified="2015-12-09" version="1">MSLNIKTCHFSQKNLLRKKMSSEDYYGSSLDVSSDEDIHIDFNSSISKTIHNQLHTPQNLHLVRAHTIAEMKFSGEEEVNKSSHEIKNSLTKEEPLTDLVDKLDTDIQNLLTINSLYNSSSSIDKKKDFVNNLNEEYDYISSDDHSNSSKLSSFSSSSNTDNIVTTFPEEFIQKSGNIPSNNNKFKPFKSTTKKLLRKSNSSVSNDSGIQLAVAGTKYIHCTEDPLAKIKNVKKERFMNIHKEEPLPYPKSFSWDWPYCNEGVAKGLYTAEAFTVCLPFNNGGTGVSNNTTRKFEKISESNFAWQVGLSNTSITGNCFWRMELEVIKGLNMIALIVSRDISRLDDTSKRLKRVRKVYKLPNYYDVTTLATKSYDWGIVLTANKREESRSGKSSKFKRADTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8B8</accession>
    <name>A0A0N5B8B8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8B8"/>
    <dbReference type="WBParaSite" id="SPAL_0000229100.1">
        <property type="protein sequence ID" value="SPAL_0000229100.1"/>
        <property type="gene ID" value="SPAL_0000229100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894063" evidence="5">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000229100.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16041" checksum="89B9CAE1888ABABF" modified="2015-12-09" version="1">MIWKIFLLYLCFIISNIFGAGIIGRKQTVGVRGILKCNGVPAKGVKVKLYDVDTFDIDDLMGEAKTDNNGRFEIQGTHKEITTIDPKLNFYHKCGSLVGVCSRKFSIKIPDKFVSDGTQVKRWYDAGTLELAGKFPGETKDCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Z1</accession>
    <name>A0A0N5B8Z1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8Z1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0000251300.1">
        <property type="protein sequence ID" value="SPAL_0000251300.1"/>
        <property type="gene ID" value="SPAL_0000251300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="38"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000251300.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35867" checksum="0715DE006D12AB0C" modified="2015-12-09" version="1">MAPERQFHETDEVLCYDKNFPYAELGVIFNTGSCIYRNVVIYGIGDKKEILENLQRDQLSGMPSIYFEGNSIRFGARQLLDAVNEECDLGITYTKNDLTKYAEMIKEELENTEKNFSLALLINNCDYEELIYDTTLQECLTTICSTKKIFFIGTCTHPLFPSPGSNAREELRCYFLKFSTFKYLECEDGDDDDMDVDGDEVTHKTQSIKVVYDSLTPNTKKLFTLMMQLFVKNNFKSIFSDDLFSQARDEFLVNSVTVMQEMMTEFLDHEIVNRHHDSAGKVKFILKIKKNVLIDFMESEGLELEEEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9K0</accession>
    <name>A0A0N5B9K0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9K0"/>
    <dbReference type="STRING" id="174720.A0A0N5B9K0"/>
    <dbReference type="WBParaSite" id="SPAL_0000271600.1">
        <property type="protein sequence ID" value="SPAL_0000271600.1"/>
        <property type="gene ID" value="SPAL_0000271600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000271600.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38198" checksum="B48A120F52AD5636" modified="2015-12-09" version="1">MESDEEEFDNGECFYYTKLSDVFEKNNILGEVVQNTDDFIFIEEVGHGTYGEVHMVKKVKDNNKISVLKEVYAFNTDSNIVKNLINEITILKSLSHPNIIKIEGFAQNFSDGSVYIEYEYYPYTLQDIISLEKEISEGTIKSYTYQLFDALSYIHSKGIFHRDVTPSNILLSPSDKIILTDFNMSKYVQCGENDDVRCQTPCLTTLQYRAPEVLLDIPDYNESIDIWAVGCIIVEMINEGEPLFNGTSDLEQLKNIFTILGLPNEGNLPGYNDILFFQYFSVEIQEFKSLKKSLKKINDEIILDLLNQIFTYNYKERLKAIEGKIHPYLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9R8</accession>
    <name>A0A0N5B9R8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribonucloprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9R8"/>
    <dbReference type="STRING" id="174720.A0A0N5B9R8"/>
    <dbReference type="WBParaSite" id="SPAL_0000278400.1">
        <property type="protein sequence ID" value="SPAL_0000278400.1"/>
        <property type="gene ID" value="SPAL_0000278400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000278400.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14022" checksum="09A8F1B0CFE8F133" modified="2015-12-09" version="1">MADEVVNTKAYPLADAQMTQKLLDLVQQAMNYKQLKKGANEATKTLNRGISDLIILAADAEPLEIILHLPLLCEDKNVPYVFIKSKAALGRACGVTRAVVACSITQNEGSQLKGQIQKMKENVEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9U2</accession>
    <name>A0A0N5B9U2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9U2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9U2"/>
    <dbReference type="WBParaSite" id="SPAL_0000281200.1">
        <property type="protein sequence ID" value="SPAL_0000281200.1"/>
        <property type="gene ID" value="SPAL_0000281200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894167" evidence="1">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="3">
        <location>
            <begin position="28"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="2">
        <location>
            <begin position="220"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000281200.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="45228" checksum="D606C6A947A0F642" modified="2015-12-09" version="1">MFLKLDWLGAALALMPLLIQPEEVHRMELFPNVPEDISGTTFLIDLEATTLSNTVLIKCPYTKYNHKTPGDLFIADDIIESKGAFFDPEKLFAWVPLLRQSTNKTNITCGNVHIKTGEESYKAKKWIFNVLWKNGTNGEGFFKRERSISNISPKHPKCNLQYGNPIIFSSKKEGGFSFINDHKNLPGPYANQTYFYFIKPSENERIKEPCGIMQIYGDDPEIKLPNHKPTSNIQELNKTNVIKLAITGQQSIDVVLDMRGDLKYYRGEKIILTKMKYVEKGLQFIENSNTLITSNFSINGYEIVKLTYYAPYYDRDVEITERYYFAPSSNDLTINEKTVEYFTNEASRKPNCPLFYLNIETIRNPNCPLFYLNIGYLYKFKHNETEKDYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB14</accession>
    <name>A0A0N5BB14_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB14"/>
    <dbReference type="WBParaSite" id="SPAL_0000322800.1">
        <property type="protein sequence ID" value="SPAL_0000322800.1"/>
        <property type="gene ID" value="SPAL_0000322800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12 14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733393" description="Zinc metalloproteinase" evidence="12 14">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000322800.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43603" checksum="A6821496A0580A9C" modified="2015-12-09" version="1">MLLLIIFFVFILDVNGNDLREKRAIPSDMKYKWKFPINYYIEAPVNETVVDGAIKKMMKETCVTFNKSLVPLNNTVGLKFFRGIGCWSITGLFYLNQTQNISLSDKCDDHYGTVEHELAHSLGLYHEQSRPDRDNYIRIANENVDNNYTINFNKTSYNNSKTYGTQYDYGSGMQYGVYTFSKNKNQTVIPNEEIYSKMIGQRYSLSFNDYKLINMYYCVGRCSNNSIKCKNYGYPHPHKNCSICKCPNGYGGKYCDKIIKSQHKCGQRIFKLFKKPKYIKGNGRKVCTYYVFTSKKYKIQITIKNANTTKLPMCYERLGLEVKYRLDKGAVGACYCGNYKNQTLISENNKVLIQYTGKTKDNYFKIKVERFLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB82</accession>
    <name>A0A0N5BB82_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB82"/>
    <dbReference type="STRING" id="174720.A0A0N5BB82"/>
    <dbReference type="WBParaSite" id="SPAL_0000329200.1">
        <property type="protein sequence ID" value="SPAL_0000329200.1"/>
        <property type="gene ID" value="SPAL_0000329200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894023" evidence="1">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000329200.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48045" checksum="132ECFC3E8D883B2" modified="2015-12-09" version="1">MHFIKYFTILVLLAVQYSFQDDTTTYATTPDCTYNCGFGTTQESPSDFVYRKKRSALKLFANNRLGNDSNDLVPGVPLFNAFKQAELGLSKDAQHPFLAHSRAELGLSKDARHPFLAHSRAELGLSKDAQHPLFAHLRAEPGLSEEARQTLMSSMTSPEASAPPYGDSLEGTNVFASSNKGSKIRSSFNNLINKITNPVTSKSAMESTIPLNRTKRQVDLDNVVKLILDELKSDQIETLKYSPSDYDGLLQKQKARMTKLLQDLGSDAIVDLPDVRAQVSDNLGSTRSYNALFDMVLRAKSHGAFYQFKGKSLTSFTLFISDCMTAIRQLAITDDEIPMLDRIAGRHIDYLIPRDSKIAHARHIAVERKSDATKGHKQYDFTLSEILNDIKIVLESQGMNRLEQFNARPPMENAMDVSTFAKKFNDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBZ5</accession>
    <name>A0A0N5BBZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5610 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="174720.A0A0N5BBZ5"/>
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        <property type="protein sequence ID" value="SPAL_0000354500.1"/>
        <property type="gene ID" value="SPAL_0000354500"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000354500.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35496" checksum="EA117CBEE860B5D2" modified="2015-12-09" version="1">MINNIVLSITNSFHSFLTSFVNEFFTNFNGGNVTAIEKVKGFLESLTNKTIEVNSTVLPNENSTSAVSSLNMSTELSSGNLKLIKNYSNIFTNTIVISSYERKKRSLYNDLNIISDNIFSNSINASTNSSNIQRLEKSFKEILSNEKLSHVFIDYITKNVTLSEKEKSQLSRTIFQTITSFMSNSGLQKFINQELVEYSRENLFEDDYEETYTEKMEQLIKEMGKNNGENFNTILENILPVANNYNTVDAKDIEETMHSDGYQLGIKMGLAIKPILTNFDIMMKRIEKKKKKFVDCINDSYCFQDVLLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC74</accession>
    <name>A0A0N5BC74_STREA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="SPAL_0000362100.1"/>
        <property type="gene ID" value="SPAL_0000362100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000362100.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8284" checksum="5251DB921658E614" modified="2015-12-09" version="1">MLIKITEGDTTIKLKNIFCIQLYVIIVKKNHLALVVLKTYITNHILFNQCILKNLVTFCGYLFYFWIENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCI2</accession>
    <name>A0A0N5BCI2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BCI2"/>
    <dbReference type="WBParaSite" id="SPAL_0000372800.2">
        <property type="protein sequence ID" value="SPAL_0000372800.2"/>
        <property type="gene ID" value="SPAL_0000372800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000107">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="GPHH_dom"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
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        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1053"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1352"/>
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    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="20">
        <location>
            <begin position="1511"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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    <feature type="region of interest" description="Disordered" evidence="18">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="756"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1942"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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        <location>
            <position position="1027"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000372800.2"/>
        </source>
    </evidence>
    <sequence length="1968" mass="225045" checksum="F98CA668F64AF70A" modified="2015-12-09" version="1">MSVLASMIQSSGEDEENAHEEVHSRGDLWQQTLQAAVAASGQAGDVNRKRAQQRKPLRQTNVVERNERSLMCLSVRNPIRRACIGIVEWRPFEWLILLMICANCIALAVYQPYPAQDSDTKNTILEQIEYLFIIVFTIECILKVIALGFLCHSGAYLRNAWNMLDFLIVVIGLVSTVLSRMNIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMVPLLHIALLVMFVIIIFAIIGLELFCGKLHSTCVDVNTGELAMKNPTPCGFAASAYHCEPNFNQINMTISKWVCSSNTTWQGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGVEWPWIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNDDDNVEDEQQFNEDGMDEEGEERTEDSRPTWFIIKMRLFQKWNRRCRRACRKLVKSQSFYWLVIILVLLNTLVLTSEHYGQSEWLDNFQTAANLFFVILFSLEMLLKMYSLGLTTYTTSQFNRFDCFVVISSILEFILVYFNLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIMSLLLLLFLFIVIFALLGMQVFGGKFNFDPQQPKPRANFDTFIQSLLTVFQILTGEDWNTVMYNGIESFGGVGSIGVLVSIYFIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEEQGEVEYEEGEEDYDDEKYLENRGDDDQDEDENAAITDGEKDGESKEEVGARPRRMSHVQQQNKEKQIPKASSLFILSHTNPFRLFCNKIVNHQYFTNSVLVCILVSSAMLAAEDPLQAQSPRNLILNYFDYFFTTVFTIEISLKVIVDGLVIHKGSFCRNAFNLLDILVVAVSLVSFVLKSDAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFSCNDPSKMTEAECRGEFIQYEDNNPTKPMRLRRVWTKNDFNFDNVLDAMISLFVVSTFEGWPDLLYVAINSNEEDRGPIHNARQAVAFFFITFIVVIAFFMMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRFQYRVWWFVTSQFFEYAIFIIILLNTTTLAMKHYPPDTQMDHILDVLNLIFTAVFAFEAFFKIIALNPKNYFGDRWNAFDFVIVLGSFIDIIYGKLSPGSNIISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQVFGKVALDSETQIHRNNNFHTFPAAVLVLFRSATGEAWQEIMLACADREEVKCDPASDEYKKDPNALCGVNFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIYTEGNIDEANEQLRSAIRRIWKRTPLKMLDEVVPPAGRDDDVTVGKFYATFLIQDYFRRFKKRKELESKGVNSHQHSQTMALQAGLRTLHEIGPELKRAISGSLDTDWAPETEEPQHRRTHSLFNNIVHALSGGSIKLSKEERNRRLLSVGDNNGSLSPSHSIPGDELMSLAIHSENNQISDMPNSHSIPHNLMNEVDNRMYPGSSQITTRSRILPSIHLPNYKTPDLHRSNFVPYQRISKGSSIDGEYNVPQGGQKYIFINRSAPSDSEEEDWYERRRRIDAEERMMCHRASSTLIRDPLLLPATSGYNDTYDCHVYRPAPDGKGVRLPYTSRQMMGGPIEGPPPYIPRQELTDNLVAKALSLGRYMDHNVVEAARREIAEAYQLDEPSMVRAAYSLSEHPPGPAPIDMPNSSNILHHPRHHHHPIDMHDGYREPEYLEHVGGIRPEEVNDINEYSQQGLFRPVDSHPIRNNTNQSRGNDGNSSSQEDLLLVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDW4</accession>
    <name>A0A0N5BDW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDW4"/>
    <dbReference type="WBParaSite" id="SPAL_0000419200.1">
        <property type="protein sequence ID" value="SPAL_0000419200.1"/>
        <property type="gene ID" value="SPAL_0000419200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000419200.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20494" checksum="7821720873C94733" modified="2015-12-09" version="1">MYLNDKIVQCEKRINFECILDIIFALVLFFIFTITLCFANNFIKKVFPFLFTTKTKDKRLGSTSTVQTSWSLESRNPSITREGNQEIFEEFQRQPTPTIIVESFEEQLSPSPDCFSSIDNDLEYERNKVFEYGLGKTNPHFLRVPSKTTCQFNVTVNDIHDYFNTLNVIRKLNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE85</accession>
    <name>A0A0N5BE85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fmp27_GFWDK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE85"/>
    <dbReference type="WBParaSite" id="SPAL_0000430900.1">
        <property type="protein sequence ID" value="SPAL_0000430900.1"/>
        <property type="gene ID" value="SPAL_0000430900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000430900.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16098" checksum="C53840F2A122F715" modified="2015-12-09" version="1">MSEKILLPDLAGHTLKLFQSFNTKLKSKENYQLWLDDIGAILGAHGTSLDKLQEGNLDTSQSTSFWNVLRLSLSEQLKLEFQTSRTPKTLITAIKNKFAKNPLIEVAYLERQLRLLESDNFTSFENYISALNDTSSKLDMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEL3</accession>
    <name>A0A0N5BEL3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEL3"/>
    <dbReference type="WBParaSite" id="SPAL_0000443800.1">
        <property type="protein sequence ID" value="SPAL_0000443800.1"/>
        <property type="gene ID" value="SPAL_0000443800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000443800.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12697" checksum="36B21856B2F38D1B" modified="2015-12-09" version="1">MSIKILTIFVVFVTFYLTIHGAIFRDSAVVGDEYQFKFGDNVKSLVIVRDENLEELNVGEEGIYPNVKFTKEGVLIISPVTENDFGIYHGIIENEDKDIDVSPPTLDLSPKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEV2</accession>
    <name>A0A0N5BEV2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEV2"/>
    <dbReference type="STRING" id="174720.A0A0N5BEV2"/>
    <dbReference type="WBParaSite" id="SPAL_0000452100.1">
        <property type="protein sequence ID" value="SPAL_0000452100.1"/>
        <property type="gene ID" value="SPAL_0000452100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000452100.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40094" checksum="D32572F98DB63FF7" modified="2015-12-09" version="1">MVLLEKVLTKSLKNSLKIINGVRSASHFNYVSSVADPSLGETTKMNLFQSINNAMDITLAKDNSAIIFGEDVGFGGVFRCTVGLRDKYGSDRVFNTPLCEQGIAGFGIGAAVAGATAIAEIQFGDYIFPAFDQIVNEAAKYRYRSGNLFNCGSLTFRATWGAVGHGALYHSQSPEAYFSHTPGLKVVIPRGPIQAKGLLRACVEDPNPCIFFEPKILYRSAVDEVPVNDYTLPLGKAEIVKEGGDVTMVAWGTQLHVIREVADMVEKDLKVSCEVIDLQSILPWDVETVAKSVSKTGRLLISHEAPLTSGFGAEIAATIQKECFLNLEAPITRVCGWDTPFPHVYEAFYLPSKWRCYDAIKKMINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFD8</accession>
    <name>A0A0N5BFD8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkyl transferase</fullName>
            <ecNumber evidence="5">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFD8"/>
    <dbReference type="STRING" id="174720.A0A0N5BFD8"/>
    <dbReference type="WBParaSite" id="SPAL_0000470400.1">
        <property type="protein sequence ID" value="SPAL_0000470400.1"/>
        <property type="gene ID" value="SPAL_0000470400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000470400.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37359" checksum="C8B2CCEEB1F6C0F0" modified="2015-12-09" version="1">MSSEENKISKWFPENNVPYWLRIAKKFLQLTGPIPNHIAFVMDGNRRYARNNKLLSPLEGHKVGFEQLTKILDWCRELTIKEVTVYAFSIENFKRSKEEVNGLMEMAEKKFKELLDEKEELERKQLCVRFYGDLSLLSASLQKLMAKIELVTRNYSNCFINICLAYTSQNEIERAMKAIQSGIKEGVLENESISEYLIEKCLDTRYGSPIDLFIRTSGEQRLSDFLLYQSVNTHLYFDNVLWPEFNAWHLINAIRSYQGYHQKVSYIIKMTKVKETSIKDILGDKKTAIQLQQDKFLEWFEKEHLVHLQKLATMEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGD3</accession>
    <name>A0A0N5BGD3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGD3"/>
    <dbReference type="WBParaSite" id="SPAL_0000504000.1">
        <property type="protein sequence ID" value="SPAL_0000504000.1"/>
        <property type="gene ID" value="SPAL_0000504000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000504000.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19626" checksum="A651F985B58055C7" modified="2015-12-09" version="1">MITLKHIVYIFLLIFNGIAHLAAGAYFERNPSNPICLRGSPSLMDQYHYTKSEYDEIKNYLATFSLLIGKYKDSFSFEDVIRYLVGSDGIFRHVNWEEDHDFGVVFVLLEEYIREADMNKDKILTFCEFYNYEKVRSRRKNSGNHIPVLTERLEDLYIYYHVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJN1</accession>
    <name>A0A0N5BJN1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJN1"/>
    <dbReference type="WBParaSite" id="SPAL_0000615400.1">
        <property type="protein sequence ID" value="SPAL_0000615400.1"/>
        <property type="gene ID" value="SPAL_0000615400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733420" description="Metalloendopeptidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="210"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000615400.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="62114" checksum="953D5437D2523A35" modified="2015-12-09" version="1">MNLLLTLIFILLLPIFSEEKSSGSSKQQPSKPQDKEISKAPSKENSKDSDKGKSKTPDKGSGKSPSKDKNPSKENEKNPEKDKGKGSGEGGDKTPDKDSGKSSSKDKNKNPSKVSEKNSGKDKETGSDKGGDKNSDKGGDKDSGKESDKNDPKKKPSGKNPNSNKITDSSGSKPNEPADSKPSESSGTSSSGSGGKGGKKPSKPAKPTPAPKKDELELWDTKILYMVDSKLKSEYIEIALERIQSRTCLKFEKVTQEDKTKEGIYFEKSSSSYAWYGKVLEKKFQRIHLSLATEKRVGYIMYLIGATLGLYPEHLRSDRDKYVKLAQEHFSKFVSESHKTKDTKKYPTFDMSYDYGSLMEVSAKYLSKDGEMTIKPPINEYVYMMGQRKGFTYNNYKYINYRYCSSACKNMKNPCKNFGYLKPKNCNECNCPNGYTGKLCEQVESSPKSCSKTALKASNKKATLQTAGIMNCTYTITASSNKNVVQLTIESVTTKKTIPCLQRKGLEIKYRKDRGAMGLNLCGTFQGISIVSETQDVLIQYIGMNSDNNFKITYVDKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJQ1</accession>
    <name>A0A0N5BJQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000617300.1">
        <property type="protein sequence ID" value="SPAL_0000617300.1"/>
        <property type="gene ID" value="SPAL_0000617300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000617300.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23178" checksum="E8FEF8BDD5118776" modified="2015-12-09" version="1">MPFVCAICSEAYTTNGTEHALFSTKYGHLFGKSCLEKWIQEKSRFECPTYRKLLLDSDYHPIYDVPNEFFEFQLDDKTRKCISGTSKEKQFFYKKRYGKACKIIEFFGTSNGYILIASYDVFHNDDFHNSSYEGSYFLKIYESDYVCYNRNFRPDRITAVVVNNYCKDDVEFCVGFSNGDIYKTVFYLTNGVRQTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK05</accession>
    <name>A0A0N5BK05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transcription factor Y subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000627100.1">
        <property type="protein sequence ID" value="SPAL_0000627100.1"/>
        <property type="gene ID" value="SPAL_0000627100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000627100.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13042" checksum="0F01AE96E91CCE5A" modified="2015-12-09" version="1">XAGFVGEGYGKIRYRKALKFGRRKARDNNRVRNFYQASQKRVFRTPIPRLQIQYSECGGVEANVARILRDNINALNHLQHSMHLLQEREKDGQRPNVYEKEPPQVFWYPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK87</accession>
    <name>A0A0N5BK87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK87"/>
    <dbReference type="STRING" id="174720.A0A0N5BK87"/>
    <dbReference type="WBParaSite" id="SPAL_0000635000.1">
        <property type="protein sequence ID" value="SPAL_0000635000.1"/>
        <property type="gene ID" value="SPAL_0000635000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048763">
        <property type="entry name" value="SNX17-31_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048767">
        <property type="entry name" value="SNX17-31_FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21273">
        <property type="entry name" value="SNX17-27-31_F1_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21271">
        <property type="entry name" value="SNX17-31_F2_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000635000.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="54012" checksum="9C3E543E2AE40F57" modified="2015-12-09" version="1">MIHITIPTTRVCTEYNNPKKKFHSFDFYVNGAFHATVRYSHLYSLHEKLIENFGFRLKTAFPPKKLKHFLNTKELNERRCELTSYFQDLIQNPDVSKHYLLERNFLDFQVNSFNPVSVNIAVDVYNSFGDKVTVKCNIREGSNNVLKYAVEKFKIDLTLISHFALFLGHERNKIEDRTNANDIIIKRWLKNFESPYVSLQLLNQKTAKEGIFYKVFIRKVIWDPSIEEQIMYDPGALNVMYSQAVTEFENKRMPVNKKTEDKLNELIKEESKVQFLRLCHLQGTYGYEWLNNVKCDFPEPNTECQIKMGRREIILTWKNSDTTEKSYTFRTTRIRVWRIVHNFTVDKVHIYSFNFEYLLSQGEFRWVSIETDQTILLSCLLQSMSIEILQESKNMGILINSDNICKKSANNLEQIKEQSIGSQLEENNEQYETFEDLFDHIQEGIPLQNRNVTSRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKZ1</accession>
    <name>A0A0N5BKZ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKZ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000659400.1">
        <property type="protein sequence ID" value="SPAL_0000659400.1"/>
        <property type="gene ID" value="SPAL_0000659400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF337">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000659400.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51962" checksum="E6C0431AF0E86DF2" modified="2015-12-09" version="1">MCISNRQAYILLLRVKKIYHDWGLGHIILLLTYLLYILTFASLFFILESANARSHYQTYRNKINQKRKEFITSELLPHIFNNSKLLVFIHDDKTIYLNELMQEKLGIYEEFVYGRRNGKIYNSTFTQSLNYAFTTITTLGYNNIAPITIEGKILSLFFSIIGIPLTIIVIKDIEYLLVKLFSLPSIIFKQLWYVFRFCTLQPVQEDEFERQIKESGGRVFTDYRLNTTERLLHMPLFIVIMSLLGWITIGSIFASYHQSNFDNYTTIFFIFNLLSTIGSSEVQLEDFPILFQIFFYFYTIIGLSFVSLFINLIHVKFNKAYWLPARMYLPLNGNNNGIQVATMDSFDDDLNLTESPLYHYTTMGIFQTENKCALLQALRYDNALADESTQTLDDHETKKEVKNITFYNPNTNNKKSNDDVRSLMYETYKGKPPRIISIKNDSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLP5</accession>
    <name>A0A0N5BLP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLP5"/>
    <dbReference type="WBParaSite" id="SPAL_0000684100.1">
        <property type="protein sequence ID" value="SPAL_0000684100.1"/>
        <property type="gene ID" value="SPAL_0000684100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009667">
        <property type="entry name" value="DUF1258"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06869">
        <property type="entry name" value="DUF1258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000684100.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="89003" checksum="B46670F3F80B39EC" modified="2015-12-09" version="1">MNFNLIPQWRQRRILRKTLMNRHNLVRPTPTIERGDTETDNEERSFDEDLLNYLPNPEAFLKKKSTNLIDSLTEEDTDEERLTCFLADYLRLKGEGSVSDQNSSKILNLISSFLSKDIKCPRTLEGCRSYVRNREPEVASIYGEAEEVEYDGGRLLLMPFNKIVKNVVKRNIDYLLPQVNEEGIVDINLQLHTDGVEVAKSSKIKMWPLTAIIENLPGKVRVAKSNVIVIAIHVSTVVPDFRIFCQRFVQEFKSGIQAIFYDDDDRTFSRRMVKIRVRCKMLTGDIPAIRSILNLQGHSCQFGCIHCYCESVTEASVFGQGRKRTYASSEAYALRTNDSYQKDLNQLTNAGVAFFFGVKGVSHLANLIRVPEDVSIDYFHSVLLGPFKEDMNRIVRGYQSLNKDKTVVFIKGFVESQTSHFKKAIELSLFPSEFNRKLKPLTEIDNYKGIEWKNMLLYAMPTILGDICNGSCKPLYLVNLCLANAVIVLMKDNVSAIEIKKSQEQLYQWYKDRTDILGNDAMTLKAHQVTHLAEIVQRHGSLCNYSCFFGEGLAYNLTKMISLKTLDKSLNQLKTRLTDFHVINAIGDHKKKKQLEVIDCIETRMCVRDFCHSHFDNSLLEVQELSECSFKSYIFKPAYDIPFAKDSFLAYTCEQSKFKCAIGVVKSIVSIDTKVWFIIKPMKIKSTILDKIPVNSNETVMNRIKENTMFDYYYCLEDYMSKEEMTAYRPLSYFARESSQLAMIDKSAILYKCLVINTPGRKSYCCPIIAPFEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLQ8</accession>
    <name>A0A0N5BLQ8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLQ8"/>
    <dbReference type="WBParaSite" id="SPAL_0000685400.1">
        <property type="protein sequence ID" value="SPAL_0000685400.1"/>
        <property type="gene ID" value="SPAL_0000685400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="168"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000685400.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59415" checksum="99DA6BE8150EAB3F" modified="2015-12-09" version="1">MKSKSSNKLIEKLNQFVDEDIDFVMDNPMFNPLFFQGDILLKSSQIEDIIQDLKKQIDDMNNVVTDSTGSTESTNSTEPVNSTEPAKSTEPAKSTKPPKPTKPPKSKKTKTSRSKKTTTEKPDVTDDEKIVDKATTIKEFTIRPNKKELGEEEDDYFEEGEENQSDNSRIKRDYPAVVETIKWKLPISYYINDTINSTNVDKAIELFHKNTCIRFVKEDNYIINKEGLNFYPGPGCWSFLGLRDRNASQEISLGKDCDTNIAIIQHQIAHALGLPHQESSYGRDYLTTIDKSKIMKNFEGNLAIINYPQTFIFQNDYDFGSSMHFDDTKIGKDNETIIVPKTKQYNRMKTHNRTLNFNDYKVLNSYYCSEKCSAKFDNCKNNGYLNSNSCFECKCPKGFDGYLCGNLKQSIGVCGRKDLIAGNGRQAIIGKGYSSCYYMIRSAESSKIRLLITESKNEAQEPCLENTGLEIKYRKNKGVSGLCLCGNHKNITLLSDDNIVLIKYYGKKLSDYFRLEYIAVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM54</accession>
    <name>A0A0N5BM54_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase</fullName>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM54"/>
    <dbReference type="STRING" id="174720.A0A0N5BM54"/>
    <dbReference type="WBParaSite" id="SPAL_0000699700.1">
        <property type="protein sequence ID" value="SPAL_0000699700.1"/>
        <property type="gene ID" value="SPAL_0000699700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="15">
        <location>
            <begin position="244"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="16">
        <location>
            <begin position="540"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000699700.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="102483" checksum="2FC5FC38CC431AB3" modified="2015-12-09" version="1">MCSDTKQLPASSTSSFERLPTFANPISYKLFLKPNLKTFKFHGKVTIAIDILRCTDFLKLHSNELDIHFISSTFNNGTRFENLQFIYDKTFEMIKIFFPSQVTPQKIDLHLTFTGIHNNKMKGFYRSVYKTPTSNENYMVSTQFESTYARMVFPCFDEPVYKAIFYITLQVDTPLTALSNMDAASIKYMDDGTKIVEFVPTIKMSAHLVAFAVGDLEYIENRSKKGTIVRVYTLPGKKKHGISALEVGIRALDYFNEWFDFDYPISKIDMVTVPDFTWGAMENTGLLMFRETALLVDISKTSAKQKSYISTIIAHEIAHQWFGNLVTPLWWDQLWLKEGFASFMQYLMVCFSYPKLKIWEKFLNDEMVAAFSFDSFKSSHPVEVSIVNPHELEEIYDDITYKKSNSILRMLYVYLGEEIFQKALRNYIKKHQYSNTNTIDLWNSLSEASGDDIQEMMDTWTKQVGFPIVSVNQTIKGNSRILTLSQKRFIIHGDGSESPQLWHIPIRVSTTSSNGQSKFNFLMTKETQTFTIEGVTPSEWIKLNSETTGFYRVKYNEDMLNSLIIAFHDKTLPVLDRFGIASDMFALVKIGELDGQHYLKLFEASIQEEEYVVRNIIDQDIETLSHVLSRYENSDIIKYFNSFVIENMIPLANKLGWESQDDEDVRIPQLRALVLSRLARSGHQPTIEIAKEKFYNYYIDKKDIDPNLRNLIYSVIGKEDGIEGIKKLQEIFETVNFSEVERSCIIGMAQTKDIKLLEYVFDYGIKKGKIRSQDLVHLFTGASSNKIGQDFAYKYFLENIELLFERFGGPNSSIFQKCLKFSAQHIASDKIANDFENFFKYNIDAGSQNTLDRTIKQTIEAMNGNYQLLKNCGDSFYRYLISKNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMP0</accession>
    <name>A0A0N5BMP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TF_AP-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMP0"/>
    <dbReference type="STRING" id="174720.A0A0N5BMP0"/>
    <dbReference type="WBParaSite" id="SPAL_0000717900.1">
        <property type="protein sequence ID" value="SPAL_0000717900.1"/>
        <property type="gene ID" value="SPAL_0000717900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000717900.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41730" checksum="B38D313BAEDAEFB0" modified="2015-12-09" version="1">MSLRSSSTPVKANNRLGNDSNDLVPGVPLFNAFKQAELGLSKDAQHPFLAHSRAELGLSKDARHPFLAHSRAELGLSKDAQHPLFAHLRAEPGLSEEARQTLMSSMTSPEASAPPYGDSLEGTNVFASSNKGSKIRSSFNNLINKITNPVTSKSAMESTIPLNRTKRQVDLDNVVKLILDELKSDQVETLKYSPSDYDGLLQRQKARMTKLLQDLGSDAIVDLPDVRAQVSDNLGSTRSYNALFDMVLRAKSHGAFYQFKGKSLTSFTLFISDCMTAIRQLAITDDEIPMLDRIAGRHIDYLIPRDSKIAHARHIAVERKSDATKGHKQYDFTLSEILNDIKLVLESQGMNRLEQFNARPPMENAMDVSTFAKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNI3</accession>
    <name>A0A0N5BNI3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNI3"/>
    <dbReference type="WBParaSite" id="SPAL_0000746200.1">
        <property type="protein sequence ID" value="SPAL_0000746200.1"/>
        <property type="gene ID" value="SPAL_0000746200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000746200.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="90909" checksum="6B46830DD7AD8F32" modified="2015-12-09" version="1">MGEQQLKSQIDFLNDFFNFGKEFEELGCSPTIISCHVSFVNYNTRQVWLQPIEAHYLEKKLSKLLIEWKKKIKNFKSIEENEIIDKKIYIYSTVDGKLGRCYVVKRNEERPSIQCIDVGKTETLTNDTKIYEINNDMISGELCYPLCFVVDYIPNAYCQRYGIPEISDIKAGSFIHAVIINVADDVFSAFIFNGYRMLYSIKNEFFKMYELGGKLKVLDQICKGKRSFSAPHWGFDKAHRITDEYTDGFVIGVPDHEHIYVRSIDLTIAYLFFVEFLNKYYNDKRNRGKLSVNKINPSNSHDLFVLYDSETTKFYRVSIISFNSQFVNCYCIDQPTLVFKNIRNEPDFLWKLKDFFMLPKFVSLVKLGNFKTYGKSNNTEINERRSRVLKLLFKNNNQVQIINNCCEEFLTVEHEGSNIVTKFKNKLVDLHGDNIDLAACLLSDQKILKRPSFGEFGKSLNASFCKKGNVLGKSLRDLCIEMPKNRTSCVESTEAKIPVDSFGMYNPKDSTLLPIDDYFDEEEEGSIDEFVKEFNKLKENTNIQLDRNYDSLTNASLHKGIHHPQYKLEAFSITNFVNENEVYIFSSEILMVYEENYKYINSYDTRKFKEIKLENVLPDTVYLIKRNEECYRVVTGNNFSNNDRGEATDSSSEDEALEDFFFLEIETKRQFKYNRKMKIYSCPLEIIKLPYPYLEVVSLSEKILDSNYDRLNLEDKIDAIKYLKKSIPLFKNNITMLGKFMTTNMGNRKILTLSTIDGTNIVMEFQKYCKDLYIKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPF8</accession>
    <name>A0A0N5BPF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 14C</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000778300.1">
        <property type="protein sequence ID" value="SPAL_0000778300.1"/>
        <property type="gene ID" value="SPAL_0000778300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000778300.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="10726" checksum="2FE035EC2035339A" modified="2015-12-09" version="1">MADIVGIIYGAIVATGGIIGYLKASSVPSLVMGVGSGAIVVAGAYYNNNHVVCGVSALLAIFMGRRFLNSGKVFPAGVVAVLSLIIFIRCIAIYYRNRPRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ02</accession>
    <name>A0A0N5BQ02_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ02"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ02"/>
    <dbReference type="WBParaSite" id="SPAL_0000797700.1">
        <property type="protein sequence ID" value="SPAL_0000797700.1"/>
        <property type="gene ID" value="SPAL_0000797700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000797700.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22868" checksum="058C4F00166D830F" modified="2015-12-09" version="1">MYERGDLSDYKIICEDREFLVHKFILASQSPVFMDIFKSSSGKKEIEDVIKIVDSKQEFVEKMIEYIYCGNLGKDLSVDESIGLLHLAHKYDIESLKLLCERELVDKLNNENVHMLAEISEKYQALNLKKVLFEEYVFNILIICYMSNFFTDLRIFFSQNKVSLTPKIKETFDFISRIPKYCYFGFTFACLGSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQV4</accession>
    <name>A0A0N5BQV4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000826300.1">
        <property type="protein sequence ID" value="SPAL_0000826300.1"/>
        <property type="gene ID" value="SPAL_0000826300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000826300.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57517" checksum="2AB6317A07B29B2E" modified="2015-12-09" version="1">XDTIDKIDEMMDKVKSRFFVTQNNNNNNNNNNNNVLENEKTLSNEQKTITTDDESVKKERLERIRARWAKLGPIIKSRVNRLFSKARLSQNYSIGKEIRRFSTTTPKTFELDKKQYIESNFDTFTEVNHNDRPVLHSVKTMTDDKFLGQNEIKNLGTYNHIIKRPPIAKPTFGNELVNLGNLDNEGDLHNRLSNNFGEQRRTHYKFVNKVSSRPRLRIRRPGNPPTAQAMENEVARAAGISSLNRGPLSLPELSPITNEESNENQKIKPIPLPSIEKSGETSRSFKSDESSESLIDSSEITFGNPPPKSDEKIKPNKSDEFDSNSKSKEHINVEIEPPLEPTDEEISSLSRNHNKKKVKVEEVDSGDSGILPQNSGLRPVAPPSEFGSTGGFGSGFGGGSAQIPSGFGFGGGMGSPLPKPSKTSSSPVNEKTIGMETNKDENDDDDGGDEEDFDKEDTAFGRPKGPSPDDGSSEGPPKPKGPDFNQEELFTGDSAFNINSKGPTGDGYGPPISSGAAVPPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRA7</accession>
    <name>A0A0N5BRA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRA7"/>
    <dbReference type="STRING" id="174720.A0A0N5BRA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000840900.1">
        <property type="protein sequence ID" value="SPAL_0000840900.1"/>
        <property type="gene ID" value="SPAL_0000840900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000840900.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18012" checksum="A141AFF3ADB09BFD" modified="2015-12-09" version="1">MNEIRSIEELEKEIHLSSHELFNHKRVLQEEIDRFKINFIDNERPVEFGSLIKLNHKILEALDTDIQYLFEKSQIKSITNNIQKLTERLGQLSKKQFSVEELNLFDPKSLKPSSIAMIADEKLLDLIESEKAVKANEEILFSTTIVEEVNEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRQ2</accession>
    <name>A0A0N5BRQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BRQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000854700.1">
        <property type="protein sequence ID" value="SPAL_0000854700.1"/>
        <property type="gene ID" value="SPAL_0000854700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="26"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="236"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000854700.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="56833" checksum="8E30DDDD4999F446" modified="2015-12-09" version="1">MFPKSIIYFGLLFFQLFFVYSSPDEARLYRDIMNGYVVEERPVIDPSSPVKVRLTVILQQIIDLNEREETLTVNAWLNYLWQDTNLRWDPRQYGGVQDLRHPYGTIWNPDIILYNSVDSSIDSTFKVNLISSYDGNITWIPPGIFKIACKFNIYWYPFDEQICFFKFGSWSFHGAQLDLIEGEFDLSEYMLNGEWIIIKSWVKKTVKQYDCCEEKYPDLQFYVHLRRRTLYYAFNLLMPCALIMILVMLGFTLSPNTCEKVGLQISASLAVTIFLTMLSEVTPQTSEAVPLLGIFFESCLIICILATAFTVYVQSLHFRNQDSHKRMGFWMRYILLEWMPYLLFIKHPRRENNLKTLKKTWAERKKYETDIRTAFVYNDDTCRVMTTLGSVLEENFDHVIMNIKKVSNDDDQHLVDQLKTLDRIYKHVKIIRQNNDDEVEGSRIRYEWQFAAMIVDRLGLIVCTIVTLGTTLTILLRAPYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSB5</accession>
    <name>A0A0N5BSB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSB5"/>
    <dbReference type="STRING" id="174720.A0A0N5BSB5"/>
    <dbReference type="WBParaSite" id="SPAL_0000875900.1">
        <property type="protein sequence ID" value="SPAL_0000875900.1"/>
        <property type="gene ID" value="SPAL_0000875900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000074">
        <property type="entry name" value="SHaW family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
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        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF234">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000875900.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69833" checksum="2F21705DD5171AD2" modified="2015-12-09" version="1">MSFRRSFRNLDRQSFKQANKELDERGILMDSEYRVILNVGGIRHECYRHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFHMILNYYRTGKLHYPLDVCGPLFEEELKYWGLDANEVEPCCWMTYTQHRDTQDVLATLDKLDIDDETLNNKEELYKLFGWEDDYYNDNLSSWQKLKPKLWRIFDEPSSSRLAKIVAVISVFFLCAAILVFCLKTHPGLRVYDIGNITSTSYIPTIEENISLQNDPSTPYIDSLLKSNELDRGKRSLDSKDSKLFSKYQPGDYHLKVYEDGSVKIQQLRHQQHLKNYEQEFVPKRTNKYRTEAIGVDQKSSRPHSSFILVELICNIWFTIEIVIRFLTCPSKAKYFKAPVNIIDLVATATFYIDLLLTTFGATADLEFFSIIRIMRLFKLTQHSQGLKILLHTFKASAKELMLLVFFLVLGIVVFASLVYYAERVEVNPGNQFQSIPLGLWWAIVTMTTVGYGDMSPQTTIGRIVGSLCAIMGVLTIALPVPVIVSNFAMYYSHTQARAKMPKKRRGVLSIDQIKQHPMPPVRRNCQVSKCTTDSNTPLINKNSMHGSNTNLQNNGLSTHLSNKLGAMNNVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT11</accession>
    <name>A0A0N5BT11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT11"/>
    <dbReference type="STRING" id="174720.A0A0N5BT11"/>
    <dbReference type="WBParaSite" id="SPAL_0000900500.1">
        <property type="protein sequence ID" value="SPAL_0000900500.1"/>
        <property type="gene ID" value="SPAL_0000900500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000900500.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39376" checksum="728B71EE8B757775" modified="2015-12-09" version="1">MDSSEPKEEKTTESTEEERLEKIKKIFGIEREQEEKNAWQNVSEQDISRLLDELCLDPTQNLHDYRCILLRSTDNVTITSAMRIFGKYNPLEIRLVNSFSAIIHLESPIICAAALLDVSKPLRRIKYKVIDDDIEEDEEEGMIINNKGDPVVIVTCKKNDPKLIKRHNKEDDFVEVDVDRVGIPEGAWRVTKHTTNKVLVLCTFASDLDFKEARENKLEIWKSSRKKVIPSNDIFSRITKIGTEGDTKISFSREKNDEMNNDVWRRDKTIIREGLNIFNKQGEELDFDFEHCVRTFVNPENDNVNKRKIGEEKDDKKDDEPATKKVRGRGACKFKSGIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTD0</accession>
    <name>A0A0N5BTD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTD0"/>
    <dbReference type="WBParaSite" id="SPAL_0000911500.1">
        <property type="protein sequence ID" value="SPAL_0000911500.1"/>
        <property type="gene ID" value="SPAL_0000911500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000911500.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11967" checksum="643C5C86F9D76032" modified="2015-12-09" version="1">MIAFASLRNPIFAIGVFLYLLSYLSIILPATAKPHSYQKDRNYVDGVQYTDLSRVDHQTGIFIDIVPVESKPAPRPIKHFKTRKSNHYLEKRRKYLESQNNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTF5</accession>
    <name>A0A0N5BTF5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TF_AP-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTF5"/>
    <dbReference type="STRING" id="174720.A0A0N5BTF5"/>
    <dbReference type="WBParaSite" id="SPAL_0000913700.1">
        <property type="protein sequence ID" value="SPAL_0000913700.1"/>
        <property type="gene ID" value="SPAL_0000913700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="294"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000913700.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="60490" checksum="AEEB75CB02259697" modified="2015-12-09" version="1">MPTHFTPPSNHAIMISNNDTQNPPYQVTFSDGDSCDITKLNKLPSDDLKNNEDRKRALEGTGDRNSGILSKKSKTGDGEEEVKGKGNNGNPPSEEDDSIVTIGNIPSLLTTPLSSSTPYTSGNGRQDPNVQNYMLGNGYYSNMSNYIQQINSYPQVQGIHNDGRFDYHVYNSNAIISSMPSSYPPPFDRIPALVQNMANFNNGGNQVFLNDSKITSFEKSNDSGVTSDTSSNNTPDSIIKNDIGSLKNGYSQSQSFNPVIPYINNNSSNDSNNSNDSGNTHINRNFVLPPYEIFCTVPGRTSLLSSTTKYRVTIAEITRRINPPECLNASLLGGILRKAKSKDGGKMLRESLRRINLILPAGRRKAAQVTAFTSLVEEEAIHMAQDFSKLCDKEFPAKVIGQEIVNNELNTNADYERMRTILSYSRIGIKLVCELLNKDKSPIASTSEPILLDPSVQRPLTHFSMLTHGFGSLALLASFNAFNNVLSEASKHLDSQFRQSQMNQMQTFGMSVHPGHHFQHPMNINSTHQMQRSMGLQSVENHVNIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTJ6</accession>
    <name>A0A0N5BTJ6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTJ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BTJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000917800.1">
        <property type="protein sequence ID" value="SPAL_0000917800.1"/>
        <property type="gene ID" value="SPAL_0000917800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000917800.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26784" checksum="1CACA3650E5AB104" modified="2015-12-09" version="1">MDEYKRTTTPTCTGTSVFATVYDGGVAICSDRKVSMYKMSRFRGVTRQYQLNKYCVVAFSGDFADFQWLQNILQQEEMRLRLTNPKFFMTPKAVHSYLSDLLYYRRSQLNPIWTQLLVGGMQPIDNDFTNMEPYIGVITPKGVSYKAKSVATGMGAMLLNQLLETDVRAKNYQLSEAEAKKLLTKLIELSIYHDCEADNCFDISTIDTANGVRRDNPMKILGNWDLATYNNDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTL9</accession>
    <name>A0A0N5BTL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTL9"/>
    <dbReference type="WBParaSite" id="SPAL_0000920050.1">
        <property type="protein sequence ID" value="SPAL_0000920050.1"/>
        <property type="gene ID" value="SPAL_0000920050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000920050.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9374" checksum="FD29EBD4947501E2" modified="2015-12-09" version="1">MDRIIAPKIYLNDITDGIQLYNSLYSHTILPQMLRSDKKLNNLYISKALAEEVVDTRTNGVYANKQKKYIEVKKYFDIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU37</accession>
    <name>A0A0N5BU37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU37"/>
    <dbReference type="STRING" id="174720.A0A0N5BU37"/>
    <dbReference type="WBParaSite" id="SPAL_0000936000.1">
        <property type="protein sequence ID" value="SPAL_0000936000.1"/>
        <property type="gene ID" value="SPAL_0000936000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894948" evidence="2">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000936000.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="13167" checksum="00757CBFC9FD72D6" modified="2015-12-09" version="1">MKFFTASALVIALASSGSGGCGCAPPPPPACPPAPACGGASYAPPPPPPPPPAPVGYAQPPPAPIGGGYASAPVGGPIGGGYASSGPVGGPIGGGYASAGPVGGPIGGGYASAGPVGGPIGGGYASAGPVGGSVGGGYASAGPSSQYAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUN5</accession>
    <name>A0A0N5BUN5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUN5"/>
    <dbReference type="WBParaSite" id="SPAL_0000955600.1">
        <property type="protein sequence ID" value="SPAL_0000955600.1"/>
        <property type="gene ID" value="SPAL_0000955600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000955600.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21765" checksum="0ED72C614BD37324" modified="2015-12-09" version="1">MLLLEILRNVIGNVKQFKVVFVKLNNLPYTLSQYNCLINEIPKRYRQKTSKQTISDKALAYYDPSTEMALPKFFQLHPTPYKKFSNQIQSPSDEVPSTSFSDGEKSSVTTTRLPQSTTPASCKRIIFNKMVEAPILERWYEKVLFSSKYQSNVIAEILKEATGRFQEKIVSVKKVYNWFTNKRYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUQ2</accession>
    <name>A0A0N5BUQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BUQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000957200.2">
        <property type="protein sequence ID" value="SPAL_0000957200.2"/>
        <property type="gene ID" value="SPAL_0000957200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000957200.2"/>
        </source>
    </evidence>
    <sequence length="422" mass="50222" checksum="41DD82273BAC0D43" modified="2015-12-09" version="1">MKKKNNLSDILLPGNFTLWKPRNFNLKCSKILNGDINYINKIKEKRFTMKVVPKSYKYDCESIKSRGFYSKVPLSDIEANYPIAYARNVYNNYHMLELEFLVSYAPQNHYCFSVDLKSTELYKQLTSLAKCFDNVYVPSKRYLMNSNGIYQSLSTYECMKILINKKWNYLFILQNDDFPIKTNREIVEILKVRNSTLDMEFRDPSPFIQDRINQNASWDYKSLNFFNETEIVKYDKNLLSKNIQFSKGSYASGIPRDSVDFILNKINITKYLYQINTVNKYGEDEMVWQTLFSDNLLKVPHYVDRNCLSTTYNEVIFMVRNVIWEDRECKTEIRHHFACVYGVEMLRDLQNMKSIFGYRFIPEHDFGGALCFTEYLFNKTYLKKFEKIDTDFYVNLPSTKYQNANLLEKVEIIEDCNLNKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUQ6</accession>
    <name>A0A0N5BUQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000957600.1">
        <property type="protein sequence ID" value="SPAL_0000957600.1"/>
        <property type="gene ID" value="SPAL_0000957600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894965" evidence="2">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000957600.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20534" checksum="C48CB5B27D157733" modified="2015-12-09" version="1">MKNIVLVSAFLFFISFLLTESFEFKKSLISNNENNDNSLLPAILNDDEDINFINKRSKIKSSKSNNDIISKSKTKDKKRKKNQQRSRESFESKTLKYIAKAISDFTNRLFNFAVDVKIKLDRLPTVCPSGTTKPTPTKTKRPGQRPQKTTRNRHKPKNSNNSKRPNKQKITTQIKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV07</accession>
    <name>A0A0N5BV07_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV07"/>
    <dbReference type="STRING" id="174720.A0A0N5BV07"/>
    <dbReference type="WBParaSite" id="SPAL_0000967500.1">
        <property type="protein sequence ID" value="SPAL_0000967500.1"/>
        <property type="gene ID" value="SPAL_0000967500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000967500.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48742" checksum="FADBEB6ED815F9A2" modified="2015-12-09" version="1">MAIRDKYSSRRKIITEERPPIYSFVEGIYSNIKYFFERYLERDCILSHEEITRLGNHKYSASDNSILVNLFFRNFWDWLIQFFPTWLAPNTITLIGLIINLITVLTLSKFCYTATEIAPNYAYLIAAIGLFLYQTLDALDGKQARRTQSSSPLGELFDHGCDSMTQVFVTLNICYALQLGEYFSLVFVTNLISVVLFYCAQWQTYCTGVMKFGKFDVTEAQWTVITILLMTAFFGPQIWTYHLFGLPLKFYCICFSLFMAIVQFLGYMKGVFTEGVGKNGSTVAGTSVLFPVCPILATCVPFWMIYFKSTTGVFEKNITLFVLCFGAVGAKATNRLVIAHMSKSELGIWDWIYLAPISMILNQYYDNYFSEYKVLLSVTIYAYISLLIFCVTVCNQFCNHLNIYCFKMGKREGNTKGASVYLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVQ6</accession>
    <name>A0A0N5BVQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000991200.1">
        <property type="protein sequence ID" value="SPAL_0000991200.1"/>
        <property type="gene ID" value="SPAL_0000991200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000991200.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51864" checksum="1E1C4D6A1071646D" modified="2015-12-09" version="1">MDKPTLLSAEKSDCQSCIATAESEQRGSTKITPNNQLNISEEDIEKFKSSLRLEGNLRTYNNDSTKQKSPDVSTSIVSKEEESKNAPFLKNNDGSKITVIDSSSRNNYNHSSNKPNAPFGGFNNNIKNENNLSLVFNDHSAKNKYDINTMKLPTIEEIKYAVQNPKCDIKFSFYELFKKLNENHENDVRSVINECIKHVLCQDITKIIMYFLDGQLETDRTVMEYLTLDTYGIDTTEFENVAGFSFNNVIEWGIGNDYFTKLDNYKIMLKKKSNNFEKDIFCEENLNIHNKKNEKEGRESDISTLANDSLLINEIKGKMILLYVLYMGPPEKIYPIPQFDNNIFYFCDEPLDENFCKKYFNCDCFEDVCSKYFDNAIEVKKENGTIFFVLNKKENELWEMFCVNVEKYAAITGKEVDITSISQIPKETNITKNIFGIWIPKDIKFSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW87</accession>
    <name>A0A0N5BW87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BW87"/>
    <dbReference type="WBParaSite" id="SPAL_0001009000.1">
        <property type="protein sequence ID" value="SPAL_0001009000.1"/>
        <property type="gene ID" value="SPAL_0001009000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20818">
        <property type="entry name" value="C1_Myosin-IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000008">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000005">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="181"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="1295"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="1536"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="15">
        <location>
            <begin position="1601"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="275"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001009000.1"/>
        </source>
    </evidence>
    <sequence length="1976" mass="227782" checksum="0136E600DFA255B9" modified="2015-12-09" version="1">MSFDSISSTTGYSSSGIPLLSVFPRRALTIAAPDDTITHTRVTVYLHSFNPENSNHKISFDFHKRNTTEELIEKIIESNQDLNGTNSEDYEIYETMGTLDGRTFKERRLDRGEYPIAVQMLWSCNNHNSSNENDSTIPRNRFVFRSKSSRPKRNVVNFVSAENCSTIDSFLAKFLAQPQDREYADLCMLPELTEQTLLDNLKDRFNSGHIYTYIGPILVAVNPFSFFPIYNPKYARLYCQSRRLGALPPHIFAIADITYHNMLRVKESQCVVISGESGSGKTESTNFLLHHLTTLSQKGSTTGTSIEQTLLSAGPVLEAFGNAVTVQNNNSSRFGKFIKVNYRENGMISGANVEIYLLEKSRIISQAIGERNYHVFYYLLEGSSEEEKINYNLLPPTNYYYLNQNNFFECDTMNEKNEYYRLKKSMEAVGFSLAQQQKIWSVLSSVLLLGNIRFIKRSGYHSDENAFIENEEVLSIITKLLDLKDKQLLEALTIRKTMLRNETVVTRYNIDEAINTRDAMAKCLYNALFHWIVLRMNQALLKKESTLGKKGFYIGILDIFGFEDIGGKLNSFEQLCINYANEHLQAYFNQHIFQFEQEEYLKEGITWTNIEYTDNTECVHLFQSKPYGILRLIDEESNINNGTNISMLEKLNTFLKNNEYYEIPHKKEDAFIVAHYAGKVKYQITGFREKNKDLMRLYVVMVFKNSKSSFVRELLGDDPVAIYRWSLVKNTFRAVNAFKQSLKIPKRAESVDHLVLPENEQKKEHSRRSSDSTLNQFLRGDLPSGIVPDFCDTSVFKTIVNKARKQCAKPKVERLSNLKSLQAVKEIYGRKPISNKPSSVSKQFEYSLNRLMKTLAKATPYFIRCIKSNNEKIPNYFDDNIILRQLRYTGMLETVRIRRAGYSVRIEYEAFVNQYRILLPNGLNTNKKEIIEFLSNHSSIDGNMIQFGHTKIFMRDAEKLLLDDHLHRTIMSHIVTLQRWFRACSERKRFLKMRNEIIIFQAVCRTALAKKRLNERINAAVVIQSHWKGYLEHKKYLQIRKSVIELQSIARKKAADKNKPKITNRDGKKRKNKGSKSTANKFEIGTIIKKIDLPTFNLNDPSSLSHFVDQSTTSESITNDSDVFSSTEEDISEVEIDDDEAVSATFSICNEGDEIILEEKLDKDGLDLECTFVLEDTKLKLIEEEPNETAHFIRRQSIATTSSTAKLKTLRRAASTESDQIPRIEGIKSKNDVPIKDKVKSRKMNFIKAKKHLKALLTRKTTDLPITLSDDEICEGDSSSNIIVEKNKNIKIHPKHSFKLSRLHISENCSYCHKTMSGLLVQACKCSNCKLSFHKDCAQYAHNMICFSNKLNEQLMVKGGKHDDQHKSPRGSLSPIVVSPTNNQGTFNLTKTKQQTDPSHLVIQSLEDLRLFSVFIFKKQYRLDQHKKRDTIIDAIFKQSLREFHMELIGYEAVLQEDGNVLKYHNMITTFDGLLTKVSNREGVFFPTTLGVNAFRGFLNEFIQEQDKRKNVSKKSGIIKSVRKKRRKSDITIHNGHRFRLELVHVPTYCEICNQFMWHSEKIFICDLCRLSCHKKCHVKVTNICSKFNRNGILGHRFFGTSLSYLMDDSETIPTVLNSLLMNVEVRALFVEGLYRKTGSLTIVRTTRKQIENCEDYDKLNFDEVPVHVVTTLIKAFFRELVEPLITFELYENFINVSEVEDNMERVRCLSVMTDLLPKCNKCVLDRLMYHLARVAYQETVNKMSASNLALIFAPCILRRQQVVHAQEQLQDVHKQAICVQTLIEEKLRQYKATLTQIVEIEQATEKVSENLRKIDEHRRLSECVGSSTMATIKEESNNEITKSEPVLKTSSSTNIEAARQLFVEQLSFLDKEKEKLISELPPMAPVASSEDLSSAEEYSLSPQELSREEYAIDFDNPPVYSILKSVNKNRPKRVGIRLPKKYRDMVEEYRKEKLEDCKRNEKIVDEINRSSVIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWD8</accession>
    <name>A0A0N5BWD8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWD8"/>
    <dbReference type="STRING" id="174720.A0A0N5BWD8"/>
    <dbReference type="WBParaSite" id="SPAL_0001013500.1">
        <property type="protein sequence ID" value="SPAL_0001013500.1"/>
        <property type="gene ID" value="SPAL_0001013500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001013500.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40927" checksum="E8D099BAD8B5522E" modified="2015-12-09" version="1">MEVSELYDDHVNSPTITYRDLKLLRILRKIESKGHCLTEDDFENGRVTITSIGLVRPYYFYGKNAYRDFVLTYNLDPYNAFTGEDLPVKNGFIKLIFYDGCVVVRKEFLLKYFAYFKFKFDCITDKQVNIFNIEDFSFNHFVVVLKYYYAQIIVITLDMIVELYRLADFFVVDYAFMKRITVYINCFYSKIARTIGFYRYHKYFEEEYLGGDNTGLQVTSEEEDQDIDRLYYLYQRKCNNEADINLIMDNVNDFDEDSDDEEDDEDNDEGNLDDESMEYSSSMNEDGDDNEDMVEDIDEEMEDDTEYNIEINEESLVKNNDVEFEHFKCKVINKMEDYINKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWI6</accession>
    <name>A0A0N5BWI6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="STRING" id="174720.A0A0N5BWI6"/>
    <dbReference type="WBParaSite" id="SPAL_0001018000.1">
        <property type="protein sequence ID" value="SPAL_0001018000.1"/>
        <property type="gene ID" value="SPAL_0001018000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF62">
        <property type="entry name" value="DNA TOPOISOMERASE 2 TOP-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="487"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="747"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1239"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1280"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1285"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001018000.1"/>
        </source>
    </evidence>
    <sequence length="1355" mass="154736" checksum="F6CFA962177E4EF0" modified="2015-12-09" version="1">MSSSDSDFQEVVVKKKKQPKSPKKNGPSPNTTLSREDLSVFTNIDNVKSGKSGKGSIEQMYQKKSQLEHILLRPDTYIGSVEYTDKTPMWIYEIEEDKLVQREISYVPGLYKIYDEILVNAADNKQRDKKMNLIKVDIDKANNTISVYNNGKGIPVAHHGVEKMYVPELIFGTLLTSSNYNDDERKTTGGRNGYGAKLCNIFSTEFTLETSSKEYKKQFKQTWINNMTKDKEPEITKATGEDFTKVTFKPDLKKFKMKELDNDIIGLMARRAYDIAGTTPGVRVYLNGKVIPVKSFKEYAEKYVESVVGEDNEKPKIIYEKVNDRWEVALTVSDKGFQSVSFVNSIATSKGGRHVDYITDQITANLIDTIKKKAGGAKSGVNIKPFQVKNHIWVFVNCLIENPTFDSQTKENMTLQAKSFGSKAEMSEKFYKESLKCGVVEAVLSWVRFKQQEQADKKCSTKKSTKVKGIPKLEDANEAGTKNSYKCTLILTEGDSAKTLAVSGLGVVGRDYYGVFPLRGKMLNVRDCPLKQVNDNQEIGHMIKILGLQYRLKYDTEDERKTLRYGRVMIMADQDQDGSHIKGLLINWIHCNWPALMKNNFVEEFITPIVKASKGNTSLSFFSLPEYMEWRNNTDNWKSYKIKYYKGLGTSTSKEAKEYFSDMNRHRIPFTYSGPECEQAVEMAFSKKKIEARKVWLSNWMREKKSRRENGGIEEYLYNKDTRSVSFVEFINKELILFSNMDNERSIPCLVDGLKPGQRKVLFTCFRRADKKEVKVAQLAGAVGEMSAYHHGEQSLMMTIINLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASPRYIFTQLSPVTKTLFVQDDENVLRFLFEENQKIEPEWYCPIIPMVLVNGAEGIGTAWSTKIPNYNPRDVMANIRRLIRGEEMKKMVPWYKHFEGTITQVDEQKYISSGRVGILDDESIEITELPVKTWTQNYKESVLEELSNSTDKSPALIQXXXXXXKNITLIRQLSIHETFKLQTSINTSSMVLFDAEGCLRKFESPEQICQEFFVVRKKKYIERKEFLVGMLEAQSKRLSNQARFIVAKIKGEIIMENRKKKNIVDQLIKEKFDPDPVKAWKDYIKKKELEMCGEVEIEEEEEIEENETSTDAGLKKRLVDYDYLVNMALIKLSEEEKDRLLKESADKLAELEXXXXXXXVSSFKPNPSAEIVKVEKQLLLNKYEKKPKKEKVPKDVKIQKNEGQDITKFLINSKDNANVPASESPKKVPKKSKKSKDDSCEIIDDSIEVLSISESDDIRSSPKKSQKNEISKKKTQKRKKILSSSGSEDGSDYEPSPKKAPKNSVKVSPKNQKKRTIVISSDSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWM2</accession>
    <name>A0A0N5BWM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWM2"/>
    <dbReference type="WBParaSite" id="SPAL_0001021550.1">
        <property type="protein sequence ID" value="SPAL_0001021550.1"/>
        <property type="gene ID" value="SPAL_0001021550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001021550.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9078" checksum="4B7980C940B9E915" modified="2015-12-09" version="1">MDNGNILKDNCSVNDNVIEFNCGDLKLISGRPFESENFVKEFSNEFESNIKSIARNDPHKFTDKTFFEEKSELNKWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYJ1</accession>
    <name>A0A0N5BYJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BYJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001084500.1">
        <property type="protein sequence ID" value="SPAL_0001084500.1"/>
        <property type="gene ID" value="SPAL_0001084500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="176"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001084500.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48292" checksum="B14A2F86914B5D97" modified="2015-12-09" version="1">MQTKEDSSTTTNFKSPNIENDCIKALSHYDDEYQHGICQEFKKNRKNKLSDKKIPEGQKCLVCGDSSSGIHYGIISCNGCKTFFRRVVIENRTYSCQNDGKCIIDKSMRCACRHCRFKKCLDLGMDRSELNIERRRKRKTTNFEGNSSESNIQVNDSTIKLLLQREKEYVAMLKSTIAPIHSTLAESLSNPESTFLDVEKYEAVQMKPGDQTNFSYWRAKNLSTFIEWAKTFEEFKSLKQKDKESLLVHTAFSYLVLSEAFHTPERYSDRIVFPDGLSGYRNLSADILKERSGLIPTVVAVINHILVPIRKMKMKVIEYVLLQAIIFFDPECLALSQSAVECISKKRNELLKCLRIYLQSEMSNVDASARYAALLLRISNVHKVAAFKRETICTIETFNLMSPHPLTMEISKRYPETSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYK4</accession>
    <name>A0A0N5BYK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYK4"/>
    <dbReference type="STRING" id="174720.A0A0N5BYK4"/>
    <dbReference type="WBParaSite" id="SPAL_0001085600.1">
        <property type="protein sequence ID" value="SPAL_0001085600.1"/>
        <property type="gene ID" value="SPAL_0001085600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001085600.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51831" checksum="50DD5B80781A5BEB" modified="2015-12-09" version="1">MEENGTCHDLEDLFQTLNPNQREWTTYPIIRFLITFTYAVLMIIGIFGNCGVIIIVLKNKRLRNARNIFLMNLMVTDLILCCFGIPLTYIYAREKKWTLGLIMCRLTPLGSNCAVFVSSWSLCAIALDKFIHIVNPIRQPVSIRQATIITVLIWILSILVNIPPIVNSDLKSGEAFTSSFKDNKPLCGVFCEETWQDVSTRHTYGLTALIFQFIVPMGIITYCYWRILHKVAKDSIIHNVQFSNSLTASQRNAAVNRKRRVNYILIAMVLAFILCWFPLTVYNITKDFNINVPHLNLQPYFYGFIFHSIAMSTVVLNPILFWLTLKQRSKFRDLMPASEIFSTIANGVQNLRTNLSKRSVNKNTDKTKTFSLTSDITSMRNSSTFTSDNNNGSFKKHNHNKYKSRQNNEYRLHNSFSNPQKPLVNIKDDNQNDVRVVKICHFKRMHSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZV1</accession>
    <name>A0A0N5BZV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZV1"/>
    <dbReference type="WBParaSite" id="SPAL_0001129000.1">
        <property type="protein sequence ID" value="SPAL_0001129000.1"/>
        <property type="gene ID" value="SPAL_0001129000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001129000.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56613" checksum="CC4643C23367923D" modified="2015-12-09" version="1">MLFLFIEISYISQWFAKFIMNVFISILNFYSLFFLSKGFILNNLLNTSINYDAELTSKSLHEYVDLDVNPCDNFYKFSCGNWIKTRKIDIGYSEKFNNDSTTTVFDNFIKEFFAGKLNDESIAIKKIYNIRKKCEQLSVSERNKCEDKILTFAVYALKRNTANIILDDMIKRFKEEFELLIDEKKDIFDKESRDNLLKKLFEIEFTRNFDKDDTTSVLLMEKCYEEVGISENDSIEQILKKIKSLSKKNHTEYSCDDKMFNVYGYLTSAIHKNALYHAILNKLSISASALNEHWYSRYFPNALNYGGIGFVIAHEILHAFDNQNYKLVYGADEKGKLIVTPGSIENFEKKLDCFVKQYDIQKESVTNKNVNGLLTLTENIADNGGLKIAHRAYMKYLQSIGGEEPKVNGFENFTSEQLFFISFGRTFCEHKSKFYKEKEMVDDHTPSEIRINVALSNYKPFTNAFKCELNSKMNPEDKCELWKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZW6</accession>
    <name>A0A0N5BZW6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZW6"/>
    <dbReference type="WBParaSite" id="SPAL_0001130400.1">
        <property type="protein sequence ID" value="SPAL_0001130400.1"/>
        <property type="gene ID" value="SPAL_0001130400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001130400.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22349" checksum="14A18AFB7539914B" modified="2015-12-09" version="1">MFAGKKVTKNMEPNKVTEMPSDGKLKSFVGYIGNLSDKNSKVIEEQLNNKQNDRDIFKRNKVNELMKNHALNSVSKYRPRIFGSFSRETYIRKCLQMKREMHMEYITQKSNNPNTDPILWDKIKGEYSKKMNLLKKRYDSVPTDYQETPRKRPRSQGLSKRMNCIFSRKNNVFNSSMDVDDYNSFMDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0B1</accession>
    <name>A0A0N5C0B1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0B1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0B1"/>
    <dbReference type="WBParaSite" id="SPAL_0001144000.1">
        <property type="protein sequence ID" value="SPAL_0001144000.1"/>
        <property type="gene ID" value="SPAL_0001144000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="560"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001144000.1"/>
        </source>
    </evidence>
    <sequence length="949" mass="110406" checksum="21D3F04C5C5F2699" modified="2015-12-09" version="1">MGDHGQADFDRLFFDLIRVEIAVNTIPTVKKPNIERSNGGIEHGRSDIRGDEVANSCEGACRQKYSRKQRTRRPTLKLLTYNLKEGLQKEQRIVSLYKELDKTTYDIIGVCETHLREVKYQRWINGDEHHFGASEINEETKSNIGGVGFIIRAELAKTVTKVEIVSPRIAVLEMKVKRQPKPLRIIQVYAPHSGYEEEAIERFYEEIEELMKTPTYKTIVMGDYNAKVGIAKEGEKHVGKESDQERNEVGERMATFAETNRLYIMNTFFQKPQGKRYTWRAPNATHTAELDYFLSSDRQLITNVEVIRHVSGSDHRLIRATLKMNLEADRRKMFQTKRLEKTKLDEDILKQAVINTEWQLEGTLEEKANKLTETLMELQKTATTPAVGGRKEWMSPQTLDNITKRRKMEHTKENHLEYSLLSKLIGQKIKEEYNTYKLKKLQEVALQRKSLKKCKQELTIARRMMVTLKKLDGSNSKTREETEEVCRCFYTDLFNSKKYVQEKKMEDNNEEVPSILTSEIEYALKNTKNGKAPGLDTITNETLKAGGIHLWRILAELFTECLRTRKIPTLWKTSKTVLLFKKGDHEDIKNYRPICLLSSIYKLFTKIILNRIARTLDEAQPREQAGFRSGYSTIDHIHTLNQILERAEEYKLPLVLTFIDYEKAFDSVEINAVINAISKQGIQKQYVELIKDINRGCNTTIKLFHKKLQIQVKRGVRQGDTISPKLFTAVVEDVFSKLDWTKKGIRIDGEHLTHLRFADDIVLITHTMEEAEQNLNELNRLSEEIGLRINRKKTQVLRNKTSQQKEPNSTVKLGEESIEEVSSYTYLGQQISNDHNQDEEISRRRRAGWLAFRRISEIMKKLKDHKVRTQLFNSMVLPAMLYGCETWNLRKSDKEKLKVTQRAMEKRILGVTRRDEIHNKDLRKQTNFNDIVQSALINKLRWAGHIARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0L7</accession>
    <name>A0A0N5C0L7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0L7"/>
    <dbReference type="WBParaSite" id="SPAL_0001154500.1">
        <property type="protein sequence ID" value="SPAL_0001154500.1"/>
        <property type="gene ID" value="SPAL_0001154500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001154500.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="35325" checksum="EE2CE5A0AE5456E1" modified="2015-12-09" version="1">MPFFKYCEKNFDDNRNTNFTGKLYKDFEVNISNSKDEGSCDNSSSQMFREFSFNELESSDETFTFSKNEEKENIFNRFSTNPKPNVATENDDIEVIGHSYPLAVKYEISPGKVIVIYDSSNIYSIAYNKRPFVYNGRRYTSVDHVYQHYKLKELCNKKMEKTFFNMKRSYLYRKYVKKCLQLCKKTNKDVIEWRKISGLGIITQATVEKFKQNKDLLEVMKKDRAKIILNAYGGDRYDACGSIKKLRQWMNKNIYRTIDVPVYEEPIFLEYYPTISEGKNIQGILVMLARAILTENGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C160</accession>
    <name>A0A0N5C160_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C160"/>
    <dbReference type="STRING" id="174720.A0A0N5C160"/>
    <dbReference type="WBParaSite" id="SPAL_0001173800.1">
        <property type="protein sequence ID" value="SPAL_0001173800.1"/>
        <property type="gene ID" value="SPAL_0001173800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001173800.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15518" checksum="CE104E285C1D6364" modified="2015-12-09" version="1">MFPSPFSMKFHKLIRQKRLEDVRQIGMDRVVDLRFGNEDRACHVIIELYNRGSVLLTDHNYTILNILRPRTDKDYDVKFTVRGRYPLELGQYDKRIPDGERAHSLVHGQAKQHFFWLQRVHWISEMAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1F3</accession>
    <name>A0A0N5C1F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1F3"/>
    <dbReference type="WBParaSite" id="SPAL_0001182850.1">
        <property type="protein sequence ID" value="SPAL_0001182850.1"/>
        <property type="gene ID" value="SPAL_0001182850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001182850.1"/>
        </source>
    </evidence>
    <sequence length="50" mass="6037" checksum="FDA7642497ED15AD" modified="2015-12-09" version="1">MIRNRMFQECMGNFDINLTHKDLIIDNFDNINRQTTCNVFIFSIFICTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Q1</accession>
    <name>A0A0N5C2Q1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Q1"/>
    <dbReference type="WBParaSite" id="SPAL_0001226000.1">
        <property type="protein sequence ID" value="SPAL_0001226000.1"/>
        <property type="gene ID" value="SPAL_0001226000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001226000.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42756" checksum="E136D07384BBDA2A" modified="2015-12-09" version="1">MSSSHTSKSRSQTPSRIDNEDELLDDSISPTDSLSSGTRKRQAGGESICSKKLKLSENDVIERSESVLSCSGTVLPHSFLETIQSTILPFEDYITILENNTRTIEAQLLMEQLKHVAPKPISATMIMCTSSFPFWDRFINGTNAEKWRNSFLTSKNPIPKPWVLDYGAVNATRGFEVIYDSLHKCASGGMSISVVGTQSIILPSYNIPKWMHMSILHQGGALSGYVPPSLEVLILRRFTSTAVNFNGLLARSNKLKILVVDSCKLMEKMLPSITTTSSLMSVVCKQRGTCSSLKKLSKLGFDSQIILVPIEQVSNSFWKMDRRMIKENIRMPNGSGRFTRRGHIYYRDMKILPYLCNVTVPQVLLGEAKSRDALMEAKMRAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3B4</accession>
    <name>A0A0N5C3B4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shugoshin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3B4"/>
    <dbReference type="STRING" id="174720.A0A0N5C3B4"/>
    <dbReference type="WBParaSite" id="SPAL_0001246800.1">
        <property type="protein sequence ID" value="SPAL_0001246800.1"/>
        <property type="gene ID" value="SPAL_0001246800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001246800.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24985" checksum="2D1B7C0B41235BDF" modified="2015-12-09" version="1">MGNCVISGKKKCKIEEVYTKRLSLIDSPINRNNVNKKASFNVDKKEEINLVNEVENCTAENRTVNQSNVKESVNSVFLDDDDKKNGNTEVGLTYEPDNPNDDKNGSNEVSLTYEPDNHDDKENGSIEINLPCESDDHDVTKRSSSIKSLPEYSTPVGTPTVKGANFLNDDRPIQPMPTPFRISAVTPGRRIENLCDHKGRLRKDIPFRNYLARKRGKNLFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3G8</accession>
    <name>A0A0N5C3G8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3G8"/>
    <dbReference type="STRING" id="174720.A0A0N5C3G8"/>
    <dbReference type="WBParaSite" id="SPAL_0001251600.1">
        <property type="protein sequence ID" value="SPAL_0001251600.1"/>
        <property type="gene ID" value="SPAL_0001251600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001251600.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="55138" checksum="358216884611CED6" modified="2015-12-09" version="1">MSLNNLLKEDITNPLDCRIEGWRIDNGHVKYLLSCRRRVYPIKKWYLQKRYSDFFQLNESLKGYHSYLRLPGKKYFGNTNEAFISERLLHLQSFLNTIFSLPILYGNKNVWEFFGLEKGAIGDYKYWVLVLMRNQTKFHDDDSYFVECGWRGNKINYFYNSSKKGLKMLSWLPFGIDSLKNEKISNINEILEFFSSLKLPFIYPVDSRWVDEKGIGCMRNVNCKGSLRDFVWNVKKPLDNFLHKYGSHKKCISLQLNDIKVIGRQVLETLIFFYSINYPFTDIHCGNIKTNDKVFYLFDIEFTLCGHSSIHRAGMLRSNSVKTIQDMMVFSFGNCLYEMFGGGIFFPDKNPDEGYKNLPDEAFQIFRSIFEPSNNTLPSLQQLFDNIFFDIPEYKKFENIDNVDVPKNILTTLEKLKISIESRLKEDREKLYQGGCSIQKDSYRLDKLINYSRSVPSHCDDECSEKMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C421</accession>
    <name>A0A0N5C421_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C421"/>
    <dbReference type="STRING" id="174720.A0A0N5C421"/>
    <dbReference type="WBParaSite" id="SPAL_0001270400.1">
        <property type="protein sequence ID" value="SPAL_0001270400.1"/>
        <property type="gene ID" value="SPAL_0001270400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001270400.1"/>
        </source>
    </evidence>
    <sequence length="853" mass="95079" checksum="A373D2AC27350A73" modified="2015-12-09" version="1">MVNFTVDEIRGLMDRKKNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIKSTAISMFFELEKKDLEFIKGDSQLEKEKGADGKETAYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGQEELFQTFQRIIENINVIIATYGDDDGPMGAIMVDPSVGNVGFGSGLHGWAFTLKQFAEIYAEKFGVQVDKLMKNLWGDRFFNLKTKKWSSVEDADNKRGFSQFVLDPIYKVFDAIMNIKKDETTKLLERLNVKLSVEERDLEGKPLMKVVMRKWLPAGDTMLQMICIHLPSPVTAQRYRMEMLYEGPHDDEAAVAIKNCDANGPLMMYVSKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYVPGKKEDLYEKTIQRTILMMGRYIEPIEDIPSGNIAGLVGVDQYLVKGGTITTYKDAHNLRVMKFSVSPVVRVAIEPKNPGDLPKLVEGLKRLAKSDPMVQCIFEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVQAESSIMCLSKSPNKHNRIFMKAVPMPDGLADDIDKGEISARDEMKARAKVLAEKYEYDVTEARKIWAFGPDGTGPNILVDVTKGVQYLNEIKDSCVAALQWATKEGVLCDENMRGVRFNIHDVTLHADAIHRGGGQIIPTARRVMYASVLTAEPRLLEPVYLCEIQCPEAAVGGIYGVLNRRRGHVFEEAQIAGTPMFHVKSYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILQGNPLEAGTKPNQIILDTRKRKGLKVEVPVLDNYFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4B7</accession>
    <name>A0A0N5C4B7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L41, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4B7"/>
    <dbReference type="WBParaSite" id="SPAL_0001279800.1">
        <property type="protein sequence ID" value="SPAL_0001279800.1"/>
        <property type="gene ID" value="SPAL_0001279800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001279800.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11201" checksum="0292EF94BE13820D" modified="2015-12-09" version="1">MSATAFSGGRALNNKKYKILPNGRRIYFLYRPGVSIPFIANAPASEEELVPKYSKNFNKNIVVKKEHHFSHLLRQPIMSMSQWWNFEEDNRYRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4P6</accession>
    <name>A0A0N5C4P6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4P6"/>
    <dbReference type="WBParaSite" id="SPAL_0001292700.1">
        <property type="protein sequence ID" value="SPAL_0001292700.1"/>
        <property type="gene ID" value="SPAL_0001292700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001292700.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25801" checksum="23A06E6B4E5E7505" modified="2015-12-09" version="1">MSEKKIISNPAPHSALEELCFKHFKIAHQECREVNYDNIATEAMVINNKLKTTEATKFANLLIESTIEDTNNHEKERYQKYCKIMNIPDKCVDFFNEHNVTDDHIEENVKVNYRTLSRKEHKRPFSAISQNMDNIDSSDSEYDSENDINCDRNSDISFVAEQFSILEVESINDMEEDSDFECDEEFEDESEDESNSDVDMEEYEGIIEINKNRFVVWHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C583</accession>
    <name>A0A0N5C583_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C583"/>
    <dbReference type="STRING" id="174720.A0A0N5C583"/>
    <dbReference type="WBParaSite" id="SPAL_0001311000.1">
        <property type="protein sequence ID" value="SPAL_0001311000.1"/>
        <property type="gene ID" value="SPAL_0001311000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001311000.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25104" checksum="2DB931D283D9B3D7" modified="2015-12-09" version="1">MKALFGKRENPSETLRKNQRCLNKAIRELDREKSRLEAEEKKIIVEIQKMAKMNQMDSVRVMAKQLVRTRNYCKRFSMMKANIQTVSLKIATLKSQDSMAAAMKGVTIAMKKMNNRMNLPQIQKIMMDFEKQTNIIDMKGEILDDAVDDTMGDIDDPEESEGIVNQILDEMGIQIGNELRSLPEGPKNIGVKNEKDGKLVNEGGMADADADLVARLENLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5F2</accession>
    <name>A0A0N5C5F2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5F2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5F2"/>
    <dbReference type="WBParaSite" id="SPAL_0001318000.1">
        <property type="protein sequence ID" value="SPAL_0001318000.1"/>
        <property type="gene ID" value="SPAL_0001318000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF2">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001318000.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="85375" checksum="19A8C0B13EDB5D65" modified="2015-12-09" version="1">MMAILLRKSRINPLTFILSFLVGGAIIFAYLSITNNTIDEGYLAYLDKGIQMNKKLNNKPKIAIIIVVENKKHMDNYKLALTSLECYAIGLNYTFKIIDFEETKNLSLLCPQEDFFFARHCAVGKYLKDHKGSIDFGVVLDGDIGVINPYNFLESYLPKSKNEHIIMTQRLFTHEIAASPYIVRNSDEGRRFLYEWAEFFYRIPSNFHGSDNGAVMQLFLYKFGVNSTAEEFNRCYDLYEHIQKWPMFRSYTICVTSILYRNSMVENDDDDLTFGNGSIKILRRVPFRSFVRDIWDTGSKICPKDFFVHGLKHSNMGRDVPFGRWDNPLTILRFDLKKCSSPDFTKQWEIKKGFLVDTSSVYSKLSAVQRRVEKEYRDSVYSKSLPYKHVPIIDNNIYISSVFENEKDETKVILFTISSKSKRKFPFDGVQRLEGYRFEDQLKFSYSSYQGKMLESHSSENIFSQHMSDKINRRNFVLIPKDNSIEGFSVCSPILFNFPNLGKIIHFFKYWKSQGASLFIIYYHSWTKEINDFINDMKNDLNIEIIPWSNLPFNAVKSKYPNPNFQTNYHFQRLAELDCIYRSKNKVKFVIQPQLLHELDVDNVNDFLSQASELYPDASGFRFPIYSKTITSMDDFNNKKRLLKLNKRDMFNITEMSLIAYNTFSSDLDNTKEYIIDIDSKQHFAYQVGYQNISIKGKSNKIYSDWVVPLRHWSREDWIIAKNSWLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C623</accession>
    <name>A0A0N5C623_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C623"/>
    <dbReference type="STRING" id="174720.A0A0N5C623"/>
    <dbReference type="WBParaSite" id="SPAL_0001339800.1">
        <property type="protein sequence ID" value="SPAL_0001339800.1"/>
        <property type="gene ID" value="SPAL_0001339800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="164"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="407"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001339800.1"/>
        </source>
    </evidence>
    <sequence length="938" mass="106969" checksum="4F6E012A0AF6D75C" modified="2015-12-09" version="1">MYQNRRELFEDIVKKLKNQKSNDSNLIVEVEDDPALYLDLECLYKWLGIKFTGCQLTENKLPGKNFVEIEKPTGFNIDKKMKYRTCTVPNKITGIQSYMENWYPPSNIYDCWKCSQVVDSRFKGMEMSEISTILQDIESKKNKNEGMEKSRRKLPVYEKKGEIIGAVENNDVLLIKSGTGSGKSTQVGQILLNHYITQGRGGEFNCIITQPRRLAAISLAKRVAMERYEKLGESIGYCVRFDKVDPRPFGSIVFGTIGTILRKLSSGFRGVSHIIVDEVHERSLETDFLLIFLKKMMSTGCDIKIILMSATVETQDFENFFENIKVLEINGKSHNINETYLDEIIQHFEIVPRCFVPPPDYDERRDFWSFKNRPDESSISPIAVYIAEQVEEEKEIPYDIIRNCVVKIRECLVEGGRTGSILIFLPGWKEILRCMKEFNLISDEHYLVIPLHSKLSSKEQEKVFQKSPDDKTKIILSTNIAESSITIDDVEYVIDTCKQKKQKISQNRNKCSYEVNWISRDRMDQRKGRAGRTQDGHCVRLLTKKFMNSLAQHPEPEIKSSPLDGSILTIKALGLGDSKEFLRDGMEKVDPDNIDEAEIYLQEIGALDENKNLTYLGQALEKLPFSPKNAKCVLTGLLFNISSPLSIIFSFTDSNMSLFNGLEKQEDIENSVKLLSGEFKSDAIIPLMAVKISTGYYKDFPKGSSILKTINIDTTSMLMRAKYQTMGILEKMFKSNFNIDTGCPSNKKSSKDVHLILSLLVKATRPNVAIMNKNCKFIDNIGQIVVPVENSVLSVFKSIFDFEQIFNIYGQKIEGRTDKLKDCSVVSPMSILLFGSRKVEYTGSNEVLVNNNIVFRGDIKFIQMIISLDSLVDDLLQSLCVKGYWTQRELDAKDYIINLVERIVVKGYKINGYRCYKKEVTGFTKVDFKKIGGATKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C696</accession>
    <name>A0A0N5C696_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C696"/>
    <dbReference type="WBParaSite" id="SPAL_0001346700.1">
        <property type="protein sequence ID" value="SPAL_0001346700.1"/>
        <property type="gene ID" value="SPAL_0001346700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001346700.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13189" checksum="A7E0EB619AC98B5C" modified="2015-12-09" version="1">MGEHKAYSVYFGTALGANAYPWIVFTPLKVSSVWFPSNQRNLETTICIMGNPLGVMFVNIVSLAIVSSPEDLKLTIFIDGIPAVIGMIITFVFVRRNAPLFPSSAISVKKEMPYWKGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6R7</accession>
    <name>A0A0N5C6R7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6R7"/>
    <dbReference type="STRING" id="174720.A0A0N5C6R7"/>
    <dbReference type="WBParaSite" id="SPAL_0001363200.1">
        <property type="protein sequence ID" value="SPAL_0001363200.1"/>
        <property type="gene ID" value="SPAL_0001363200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="452"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001363200.1"/>
        </source>
    </evidence>
    <sequence length="914" mass="104617" checksum="6ACD943F513C1656" modified="2015-12-09" version="1">MTTSQKLMELMADMEVPPTLNSLKRDTKGHLDLNSLLSTIKTILPDDNVTIFKTMTMMLAKEYADLKTSMSSVITIKEENENMFTPQKFSQLLIETIRTVSENSLHTTSSMGNLNFTKPKLPPLPILQQKENPITFIEKFKNRFAGLTEQEGIALFPEFLEGPALIAYKAIETEKMVTLDAVLKEWISRYDPNMTPQRRVIKLEQILATAAPFTKDTPNIYMNKITAWIRELEKLKETLSYRSKMKYVLSAVRHLKRHPELTEKYLESEDTHEAYLKFQKTVLSALTKEMESQLPTKTKTDVPKQQREKFKNNDKFNNKNSILINELNSEINEIKDCSPVSLKGPVASINISLNNYSVEALIDSGANISIIATDTLKKIAKQSQHIEFLSEKNFIKIKDAQGNLLPVRDLTPSKNITPIKIELLTNTPVKSKIRQIPLPKLEILRDDIKDMYVKCIITKNKSPYNSRIVPIVKPDGSLRICIDYRLVNENIKQDARPLPHIDNILYKLAGKKRFTTIDLHKGYWQLPLHASAQELTAFSFDNKHYQFTVLPFGLSISPSIFQTIMNDILEDLDPDKIFIYLDDLLIATETEEEHWVLLNEVFIRLKKANLKINKNKCKICQSETPYLGFIISEKGLSADPIKIKKTLDFPTPRSKKQLQSFLGLANYFRRFIYRFSSLSKLLYDSLSNEKFNWTPQLENDFVTIKNELLNAPILSAPDIKKALSGEAPFELYTDASLTGIGAVLMQNKKIITFYNRGLRGSEKNYPPTDLESLAVVSALENLKIILFGAPIIVYSDHSALSVLFQKSDLSLRLLKWSLLIQTYDISFKYVRGKENILADALSRCVRPLPEQLQEEFDSPIICNLESTMLNRFPSKNEWLQLQINDKILKTVFTWLEDGIPKKSPSPELSPYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7R8</accession>
    <name>A0A0N5C7R8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fes1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7R8"/>
    <dbReference type="WBParaSite" id="SPAL_0001397900.1">
        <property type="protein sequence ID" value="SPAL_0001397900.1"/>
        <property type="gene ID" value="SPAL_0001397900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001397900.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18116" checksum="A283CA17EDBF5111" modified="2015-12-09" version="1">MSDWSSSVQRQEIKGVVEAVLEELQTTIGYEDLGEEVLEELTPFASLSEKKRSAAVKDSLIKTLELEKPVIVKAIEEMPDYIGKMKMFEDVSEDIEPWLNRLGRAMTLQKTVEEEKILVLMTLLCDEIVMYIEKETDRKPESTIAMMDNWQDQPSNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8A2</accession>
    <name>A0A0N5C8A2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L14</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8A2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8A2"/>
    <dbReference type="WBParaSite" id="SPAL_0001415400.1">
        <property type="protein sequence ID" value="SPAL_0001415400.1"/>
        <property type="gene ID" value="SPAL_0001415400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="7">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001415400.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15731" checksum="8B64B779B7C9FF85" modified="2015-12-09" version="1">MIYTKYVEIGRIVFINDGPFKGKLAAIVNVVDGNRILIDGPTTGVKRSVINLKKIVLTKFKIPLRVGQRTGKVQKAFESSGVVEAFNQTNWAKKIAAKEKRSKLTDFERYKVMRIKQLKNRIITHEFNRLKKAANKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8R7</accession>
    <name>A0A0N5C8R7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="8">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8R7"/>
    <dbReference type="STRING" id="174720.A0A0N5C8R7"/>
    <dbReference type="WBParaSite" id="SPAL_0001430800.1">
        <property type="protein sequence ID" value="SPAL_0001430800.1"/>
        <property type="gene ID" value="SPAL_0001430800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="9">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001430800.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="56391" checksum="7DE413AF09553A7B" modified="2015-12-09" version="1">MVNHINKLLSFSTTFNGLKRNICLTKNLNAQFYNNANDAIHDIKDGSKLLVGGFGLCGIPENLISAIVKKGIKNLTCVSNTAGTEKHGLGRLLETKQISKMVSSYVGENKLFMNQYMNGEIELEFTPQGTLAEKIRAGGAGIPAFYTPTGFGTLVQEGGAPIQYSKEEKNKIKKSSKPKETRVFNGINYVMEEAITGDFSLIKAWKADKLGNIIFKQTAGNFNIPMCKASKCTIVEVEEIVEIGELDPNYIHVPSIYNHRIVLGKDYIKPIERPMFRQSPNEKKVDDKPMNEGEKNRRIIASRAALEFKNGMYANLGIGIPTLCPNYIPPGITVHLQTENGVIGAGPYPERGQEDPDLINAGKEPITLLPGAAIVPSDEAFAMIRGSHIELTLLGGMQVSKFGDLANWMVPGKMVKGMGGAMDLVSAPGARVIVTMEHVDKDGNPKILDECNLPITGKNCVSRLITNMAVFDICKKNGLTLIEIKEGLTIDDIKASTGCSFKISENLRPMGQSTLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8T1</accession>
    <name>A0A0N5C8T1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8T1"/>
    <dbReference type="STRING" id="174720.A0A0N5C8T1"/>
    <dbReference type="WBParaSite" id="SPAL_0001431900.1">
        <property type="protein sequence ID" value="SPAL_0001431900.1"/>
        <property type="gene ID" value="SPAL_0001431900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001431900.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46683" checksum="59CD22E7814928B0" modified="2015-12-09" version="1">MRVTVTNDEDVVPLEVGENIVMNEFLSICKTMLPNLEGPPEKLVADVDGVKVIPVPENLSKTIGEHNFKDGSFIYVFPVARLLNPLLRQMQGGTQDTQEVQQPITGGLQDFMGGGAELNRMRADAKTLYDQALQNPSILRSISDTFPSLMEVFQTDRTFESFFNAFKKDFEVERRKQELMQDEFSEEGQRYIAERIQRQNIEENFRMAQEYIPETFFINNLLWIRLKINGVPVLGIIDSGCQSSAVVSINIIKKCNLLNLVDKRYCGAASGIGGMQNIIGKIHSTSISVNEHLFEIPIQVLDGNNSTVLIGLDMLKRNQCVIDLQKNILRFGDGTETPFLSEAEAERERALFEEQMEAYNNAQGKEEESSPSTFVADSEKLSQLISMGFEEGRAKEALRICDNNLELAVNFLFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBE3</accession>
    <name>A0A0N5CBE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBE3"/>
    <dbReference type="WBParaSite" id="SPAL_0001520800.1">
        <property type="protein sequence ID" value="SPAL_0001520800.1"/>
        <property type="gene ID" value="SPAL_0001520800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001520800.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40486" checksum="2A249EA97DB6419B" modified="2015-12-09" version="1">MSVHDHEDDLLLIEDDGEQIPVNEQGNLGVNLDFLNEDANVDMAVMLGRFSRSLKEMGCTVEAVLLLMEMEEPAAQLERKLLWANETHVSLLKKFNDMVSIHDARSYFVDRQRALLAAIPGEPTDKQKASIVTRVKAMVCKQLDYHIVRSTEDIMSDYQSIVKIGAKSVKLCINGGGKITFPSTVNLPSVTAMRLDYLSGEVSGRLPDTLQILWIDGVMRFSKMAPLTLNGLSNLQVLCVTSCHVLKNLLQTWEKGTCLRVIMTLCRIHKCQCEALIKNSPLIDLPYKVIIVPQTRYNGKTLTENAAIQKNAFHHRVGMVYYKNLGSLKLFAECELPADIGELYSERKRIREENVTESAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBR0</accession>
    <name>A0A0N5CBR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBR0"/>
    <dbReference type="STRING" id="174720.A0A0N5CBR0"/>
    <dbReference type="WBParaSite" id="SPAL_0001532400.1">
        <property type="protein sequence ID" value="SPAL_0001532400.1"/>
        <property type="gene ID" value="SPAL_0001532400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895750" evidence="3">
        <location>
            <begin position="28"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="279"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001532400.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="62119" checksum="86AD1D1288860F6E" modified="2015-12-09" version="1">MVIAWRFNIKIFLISLICLIISRLSKEINLIPTFEAYSDHMKRCPFGMFDCNPKLDHPICIPFANVRDCINDCPNGEDELCGKKQKFCDVSIDWDIYECGKCIEEDKDEVYCIDSIYKRLCNETSTIQCMTTNNCIPYQWLMDGYDDCGDASDEDDRLSEVLFKLDLNTTVGSHLFTKKPNPKKLKEEEKEKNVYEGFYQDGIFSCNENLYKCANVTECIDIFKVLDGIEDCSDGSDENYCEKYLPGCKENCAFRSDHVKFVCQCQKPLIRMSNGVCGANGSIPPIDCADYRVFYQNVPPGIYKMSARNWLASHLHENNFDVLCNFAFMGGGWTVIMQRHININNSKIDNFLNFNRTWNQYALGFGEIDNDSEFWLGNEKIHLLTTRPCCQQELGILLETTTTKEKIFLKYDSFQIKDEFNCYELKLGPLIYTSNFLAYDILAPSNGGKFSTYDRRINKFCPPNSMNPWWSHPTSCSIDYLSGSPKSNQIYKGLSWGPFRIKKIKMMIRSKRYPLHSPTAVPLQFNSMYEDNYYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC71</accession>
    <name>A0A0N5CC71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC71"/>
    <dbReference type="STRING" id="174720.A0A0N5CC71"/>
    <dbReference type="WBParaSite" id="SPAL_0001548000.1">
        <property type="protein sequence ID" value="SPAL_0001548000.1"/>
        <property type="gene ID" value="SPAL_0001548000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001548000.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20272" checksum="3D4DEB47FC303B5E" modified="2015-12-09" version="1">MSSNEKKRSEVKLKAMTIRELKEIRKSQKSSGIVIKKKDKHLTFKWNCLETLDKFVGRYKNSLLGKWISSLNGIVLGCVKTTIQRDSLIIEDQNCLHTDISFYFIIFSPKIGRTYQCTVTKVEKKYVLGKLFDIIPCFVKNAPEDVSIGSVLTFSFVRAEFKGKLAMLSGNFDSLVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCI7</accession>
    <name>A0A0N5CCI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCI7"/>
    <dbReference type="WBParaSite" id="SPAL_0001559400.1">
        <property type="protein sequence ID" value="SPAL_0001559400.1"/>
        <property type="gene ID" value="SPAL_0001559400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013198368" evidence="2">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001559400.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13367" checksum="FE3E5BCEA5018FCB" modified="2015-12-09" version="1">MIFFTFIVLYLFLEEQPNDYSFDSIDNEVPKQSKKETKKKTEKNKGKGSNNKSKGKNSGSKGGTDNNEIEKPKTKGSKKGLKPKKPKDKGKKSTLAPSSNLETGGGEGKNPELDMQLINDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDJ1</accession>
    <name>A0A0N5CDJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcineurin subunit B type 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5CDJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001593500.1">
        <property type="protein sequence ID" value="SPAL_0001593500.1"/>
        <property type="gene ID" value="SPAL_0001593500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001593500.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19484" checksum="822EBB52C8438C7D" modified="2015-12-09" version="1">MGNDSSIPLEMCNTFDTYELRRLARRFKKLDLDGSGSLSVDEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNVKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVGNLDVHEKMVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDM6</accession>
    <name>A0A0N5CDM6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDM6"/>
    <dbReference type="STRING" id="174720.A0A0N5CDM6"/>
    <dbReference type="WBParaSite" id="SPAL_0001597000.1">
        <property type="protein sequence ID" value="SPAL_0001597000.1"/>
        <property type="gene ID" value="SPAL_0001597000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000023">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="319"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001597000.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="77951" checksum="53E1DDABF3F422BB" modified="2015-12-09" version="1">MSKKNNTFGILRKDLHLNNFFRPSNQSTNFSQPVPSDFIEKESLPSVSSSNKFIQQCPNTDSIGGGRPIQTSSSIHLTGSSLNMHLTPGGGGHARRESFLYKTDPPEALACRPVSRASSVTSTEHPHPVPLHGDDLIVTPFAQLLASLRNVRTNLLSITNLPPNKLGSEDKYRSIKKAAPLHSIQLPDNVMACALETLEELDWCLEQLETIQTHRSVSEMASSKFRKMLNKELSHFAESSKSGTQISKFLINTYMDNNEEESVSPNQPEQPKEISAEDASSVASTSQSSPHLSLFGKAKTAAMSKISGVRKLKNLHSGQVPEYGVDCAKEIVVYMQMLDKWGPNIFKIHELSKGHSLTSTTYTIMKQRGLLSTFNINPHQLITYLIHLEHHYKENAYHNQIHAADVTQSIHVFLNSPSLKGVFSDLEILAGIFAAAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSSCDFLTCLNKKQRQSFRKTVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNSIVRPEKYNERVILLQSMIHLADLSNPTKPIELYRCWNQRILEEYWRQGDKEKDLGLEVSPMCDRGTVTIEKSQIGFIDYIVHPLFETWAELVQPDAQDILDQLEENRQWYLSRIPPDETEEDNMSEESNTERGTSHGSLKVLEEGEESNNITDNTGNDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF21</accession>
    <name>A0A0N5CF21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ZT_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF21"/>
    <dbReference type="STRING" id="174720.A0A0N5CF21"/>
    <dbReference type="WBParaSite" id="SPAL_0001645900.1">
        <property type="protein sequence ID" value="SPAL_0001645900.1"/>
        <property type="gene ID" value="SPAL_0001645900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="59"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="313"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001645900.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45356" checksum="3BC2713C80E8A3C3" modified="2015-12-09" version="1">MISEEKNTVSDNNLKENNSNNENNGNIRKKSSRLVVCCDPDNIIETKPTKTSKKAENVLILVSIVTIFFILIEFAGGIIANSLAIMTDAFHMVSDLAGFMISITALRMARKKPTNDFSFGFYRAEMIGALASIILVWVLTISLLITAIIRIYNNDYEVEADTMLITAGASVVFNIIMMLILHFGHQTHSHFGITHSHSHVDNGGHTHDKKNNNLDPSHIDEHRNSKSELTIQSLNHSHKHHRNINVRAALIHVIGDLLQSIGVVVAGLIIKFTGWVLADPLCTLTFSILVMLTTFHVIKDVLSILMEATPFHVSYETVKLTLLNIDEVTGLHSLRLWSLSMEKHCASVHLEITDDADFELVISKGNKILKEQFGCFFVSIQVNKTKIMYDDDISTKSSPNVDSITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFZ3</accession>
    <name>A0A0N5CFZ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CFZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001677100.1">
        <property type="protein sequence ID" value="SPAL_0001677100.1"/>
        <property type="gene ID" value="SPAL_0001677100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="111"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001677100.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60647" checksum="81F815BF4D102525" modified="2015-12-09" version="1">XSVNAPTNVKVQATSNSSVVVIWDYDDKNFDSGADGFVIKYIHEPSLRGGQHDVERWRSISIMDSKARSFEIGQLTAHKPYAFCVLTVKQSRQGPCSDPPVTIEQLKPLFIPSNLRIEYKTSNSVSLRWDYYGPSDVEFYVNRTSRKSYLDHNLKSQEMVSPGIRKILKGNDRSLLWDNLRPHMEHTFKVGVIHKDIYYWPREIMIQTDNTGPPFVDKPEFVESKSPTTMNVRLKCASEEYGPISHYWIIIVPNNYTQDNVNNLDSQTLKYHSEALKIQLHKDDINSHGNTNVIKKVKRQSIAKEESIVSITDKQKSIKRVVRYTGGPLPTVPYVTAGISAQRMQIMQKEQELFTIGDGKIYEGFENFPLHPSTKYKLMMRSFAKELEGKKAFSQRAPMNQPRAKKYADSMLTAEFSTSSSLLDRSSRHSSLWLLGPLIAMIIICIILGMLVIWWWKFSKKNVSHCSNRHGSITKVALTDSGKGVMPNETSKLLLGTDPYGRPIINAYDVQELKNMLILCLQLNFQPPHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG11</accession>
    <name>A0A0N5CG11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CG11"/>
    <dbReference type="WBParaSite" id="SPAL_0001679000.1">
        <property type="protein sequence ID" value="SPAL_0001679000.1"/>
        <property type="gene ID" value="SPAL_0001679000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="169"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="446"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001679000.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="72111" checksum="5F039AD250DD1D00" modified="2015-12-09" version="1">XSSITDFNRILYMLDPIHVNFTDEDKKNEFFTLFLDKADFPDEVVSSDESKDVEKLEYNIRFTNEFEAADPIFSDSVLDRDGVQYLALLQSMMMSLDEENISIYENGKNYLTRPLSHGFKESDIPELHGGKRLGIGSQKSVKLIEGSKDEAGISLAIDTKRTAFHEPMPLSDKFNALLASLRGGAGKFTDANVKKVIDNMKGLACHCVHLKNRIVIVSNISTETASSKKIAIDGKNCSVADYYKMKYNITLRNPNLPLVVQKKIFKGNKEECYYPMELLNVAEFQRVGQNAQTPEQISAMIRQYATSPRKRLSEIHNLFSAFQLTSSKHPVEVSITAEGRQLKPPTLLCRNNKSTDIKNEEGTWKLRKGTVFNKPSRISDWRAVLIQGNGRHDVNMEIADTFIKMYFNSARWHGVKITDCAEICQCIPNEKELLNLFDYLKEHKTGFALFMTSDSVTNLHNLIKLYERQYEIPTQDLKHSTVSKIVKHNQYRALENIIMKSNVKKGGHNFDLKDVIKPDTMIVGIGFNHIINGGEDSLSVVGYAANTRKIPSEFAGDVHYIQFARDGKIEFYDKVIQNTVKNFKASRGILPKEIFIYRTSGSEGRYNVYYINEIPYIKAKIKQYAPGAKLVIIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG67</accession>
    <name>A0A0N5CG67_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG67"/>
    <dbReference type="STRING" id="174720.A0A0N5CG67"/>
    <dbReference type="WBParaSite" id="SPAL_0001684600.1">
        <property type="protein sequence ID" value="SPAL_0001684600.1"/>
        <property type="gene ID" value="SPAL_0001684600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001684600.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29013" checksum="2C84FD4022C09FA5" modified="2015-12-09" version="1">MARTPRNPSPQEERVMESILGKSVRDGKTLYRVKWKGLSLDEATWEPESNIKQSFVKKYEESISKGIPFSETKDYSADEEKPKKAKRDKPRAVDEYGFNKYGPKYIWVKQGDDPQRIIDKINEEILEKAKTATTPPPRFVLSATQRPRSTGQIRVLKTVNSQRRQSTGSRKRKLSENGNCHLDRLMKSAKKGTRYSEVNILGVLGAQYNLMREKYYLVQLTSKNVVPIHPDDIPPKFKDECSRIDENALFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG90</accession>
    <name>A0A0N5CG90_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG90"/>
    <dbReference type="WBParaSite" id="SPAL_0001686900.1">
        <property type="protein sequence ID" value="SPAL_0001686900.1"/>
        <property type="gene ID" value="SPAL_0001686900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001686900.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10488" checksum="9B56620B44B2D7DD" modified="2015-12-09" version="1">MGDIKLLIPPLFEILLTLSLETLWEYWLEPNSTSTYKFVILNYLFIIVSGTNTISSVLVIKEVQNTATYILRYKSKQSITRIISIAYAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG95</accession>
    <name>A0A0N5CG95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG95"/>
    <dbReference type="STRING" id="174720.A0A0N5CG95"/>
    <dbReference type="WBParaSite" id="SPAL_0001687400.1">
        <property type="protein sequence ID" value="SPAL_0001687400.1"/>
        <property type="gene ID" value="SPAL_0001687400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="76"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="284"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001687400.1"/>
        </source>
    </evidence>
    <sequence length="709" mass="82096" checksum="9A951AEC6ED1D1FF" modified="2015-12-09" version="1">MGLITDKNFYKIIILSLLFYPLIVTKNETLNYYLQPPDSPYSFYEDVQSNEDKSYDNENFNIYNDKSQSIVTFEDEERLAIDMFKDYNHLIRPSPCNNISVVMVEFGMAMILLINIDEKNQIMQTNVWLTFHWNDCQFKWDPKDYGGIESLRVANDRVWLPDIVLFNNADGNYEVSYHSNVVVDYKGNVQWVPPAIYKSSCTIDVEYFPMDQQICHLIFGSWTYKKDEVKLSWYMNKRSVELSDYSPSGIWDVIDVPGQLTDDKSRIHFQIVIRRKPLFYTVILIIPTVLMAFLSMMVFYLPAECNEKITLGTSILLALVVFLLLVSKILPPTSDTIPLMAKYLLLTFVLNILTIMTTVIIINIYFRSETTHQMPEYVRHIFLTLLPQILMMRRPERIPVFNGYFVEEYNADEIFDASLLMPSMPATMLPFTNLAKKLSRLEEGKLQLIETNLSSEVPNYHKRGMFNSPKMRKICLNNIKKMSIRKFDSTKNGDGKRGSNLHGNPFKDCSQNLKENGVSCKKTVSFSLGDMKNNIDEDSIRRYSIKEHFSDTDDENFNDIPLKSDIVVQVKEKKEQHPSSTYSTNFINITSKLLGSNKSNHKTNKLQHKRSVREEIKELSGDVRETIEAIAFIAEHMKSEMGSKKIKDDWKYISMVLDRLLLLIFFGITLGGTFSIIFTAPHIFEFVDQDAVIERLKLMTAERSSLSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH14</accession>
    <name>A0A0N5CH14_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH14"/>
    <dbReference type="STRING" id="174720.A0A0N5CH14"/>
    <dbReference type="WBParaSite" id="SPAL_0001713900.1">
        <property type="protein sequence ID" value="SPAL_0001713900.1"/>
        <property type="gene ID" value="SPAL_0001713900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001713900.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30114" checksum="E00CDC70FC4AF9B9" modified="2015-12-09" version="1">MHTNNSNDMNDDKTLKNHCNTHILSSHLKEQNQQSIFGAQIGAEILDEAVATEYIQRMKSWCPPQCFEVFFGDVEDTPIEFMKINQLILSQGGTFYGGNIFKVQKYLLSIPQILVKKGILSPAALGNSYIWNNWLGDLSMQLNSIEWQAFWYIYSNVFGLHTLPLHLISFFNIFAQNQHSSQQTIEQIIMNAPLNPSFTTYTSSYLNNVPLINNSSVETSLLRNNNISQKASDELSIIESSSNDLTPFYKEKRKFFCMFIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH63</accession>
    <name>A0A0N5CH63_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH63"/>
    <dbReference type="STRING" id="174720.A0A0N5CH63"/>
    <dbReference type="WBParaSite" id="SPAL_0001718500.1">
        <property type="protein sequence ID" value="SPAL_0001718500.1"/>
        <property type="gene ID" value="SPAL_0001718500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001718500.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="41145" checksum="14FBBD8858FB585B" modified="2015-12-09" version="1">MPYLTIIILFVYTIIFLIGVLGNSMVLSIIYFEKKAKKSTNIFIMNLAIADLLFIIVCLPDSASSLFDINLLPESFCRFQMFFKYMSIFASAYTLVLLAFDRLVAVVYPLRAIYIRTFKNTIISCCIVWIISFLIYFVTFFISQNNDAKNRLSENKTIQACFDISKMSDFAETKLNIQQLFITFNITSYIIPLLAIIIMYAIILNFLHKIKSKELKTAVNKQWRRRITKTIWLVIATFAICWFPQNSRIFYIAITYPNNHSIKEHLSKTNYMIVTVIFQIMAYANYCINPILYCLMLKRYRWYVVNFWVYVRNLCLSEQNRIPIDSKYLPHKPSFDASFHNSTKSINPANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHP6</accession>
    <name>A0A0N5CHP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHP6"/>
    <dbReference type="STRING" id="174720.A0A0N5CHP6"/>
    <dbReference type="WBParaSite" id="SPAL_0001736000.1">
        <property type="protein sequence ID" value="SPAL_0001736000.1"/>
        <property type="gene ID" value="SPAL_0001736000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001736000.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14970" checksum="275E5024392DA65E" modified="2015-12-09" version="1">MAEALAGKWNVAESTNFDEYLKASGVGFMTRKVAGTVKPVLTITVNGNHITINSASTFKNHTTEFDLGVPYKEETIDGRHFNTTFTWEDGKLVQKQEAIDKGDKPSVITRYIKDGKLYIDMVCEGVSATRVYTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIB6</accession>
    <name>A0A0N5CIB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyco_hydro_30C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIB6"/>
    <dbReference type="STRING" id="174720.A0A0N5CIB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001757000.1">
        <property type="protein sequence ID" value="SPAL_0001757000.1"/>
        <property type="gene ID" value="SPAL_0001757000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001757000.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9606" checksum="34766F17930E8CB7" modified="2015-12-09" version="1">MTHVSKFVRSDAFIIDSVMENKISKFDFVAFKNTDESKVLIILNKNEGDLNIKINSINSNAVNIGIVRVEKYSFKTIVRILNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1X4</accession>
    <name>A0A0N5B1X4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1X4"/>
    <dbReference type="WBParaSite" id="SPAL_0000007500.1">
        <property type="protein sequence ID" value="SPAL_0000007500.1"/>
        <property type="gene ID" value="SPAL_0000007500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893594" evidence="2">
        <location>
            <begin position="17"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="316"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000007500.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52227" checksum="8F3D1D8C6D3AC764" modified="2015-12-09" version="1">MKFFVLFLIPINILLSQIPPPLPTKTKNYAIVESPPSLPLKRYSHVEVKNPPQLPSKRFSYVQNGHNDVPRVQSMIYHSVQSYKVGGRTFYECNEMTFHSSVEAQNYCQKLNNYELSKVKQKHWHHRSSNGYQRNSLSGSNSDLTHRRNSISRLSGSLRGRGHSFSGSRSSLSGLSKSSSRQSLADFKNHLSLRRNGVSGSNNALSSKRDSVFGSKYDLSSKINSVFGSTNNLLSRRNSVKESTGDLSERRTSSTSRKGSSLSRSRESLSNNQIGNEISEKSFGKNKKKKPESHEIWLKVWKDCTFKCFSARYYDAYKQKILLETNLYRLKHKANILQTNSQIADLAQDLAEQYLVKQKLNVKKYDNYGILYTRVKISLATTVLKDWYDTKIKYNFFLNKPSSEAANSFTQIVWRETRQLGVGVQRDDDYLVIVFVFYPKGNIKGEYGKNVHKWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3A1</accession>
    <name>A0A0N5B3A1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3A1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3A1"/>
    <dbReference type="WBParaSite" id="SPAL_0000055300.1">
        <property type="protein sequence ID" value="SPAL_0000055300.1"/>
        <property type="gene ID" value="SPAL_0000055300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000055300.1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123457" checksum="5578FC7667579AD2" modified="2015-12-09" version="1">MWRMKKVINSDRNACKYYTTEIPKFTLDMELELKGKVIVITGASSGIGLALTEILYKRNATIIMIIRNVEKAMKCTKHIRKKYPTSEGKLFIFKCDLSCYGNIIRVVFQILKGCKKIDLLINNAGIGALKERKVIGKEGSELVMASNYFGHFLLTINLLPLLRKSKGKVISITSFAFKMYELDEDFCQREEKYNGWKAYSNSKACQIIMTKKLSQIIPSSECSFIAVSPGIVNTPISETFSNKLMGRSLNFLLAPIKNFVCRKFLLTPEKACEQIISLAFLASEKIFHGAYVSQNRLIETNFNTKLENKIWLGTFYELSMNTEIETKRILRGPMANEESLVFIKKHPEIYLAYLKLEDLNLWERNVILPNEEELYIWLCEKVAEIYNIPINDKNGYNGYIGGSLGLTSIKAIFDSDTVKRQDILRSNVYSDECERLINNDSSLFEEGRLNIFVYENFIEVNKFKDKDDESYSMETTSDIVIKLNGKHDTLSKNINTSIGLINDEIKTNIQSSNIKLNSNIYTTLTEFDLKNDVETNESREENKCENFILNSSNDSNNKTLFNNKNITVEKSFKKKDSFIRRLLRTKKEIKKEDDVLCDDNIGYDVVKSADDYMCDIIPNCDEKILWSQSINENRDVISLDSSSNSGYTISNNQESFKNKLLKENGIKNSGNTKSIADNNKFDKRERGRNLFNNVKKNSSSLKTAKEKLKRYDSSQISSTKQSNLSINPSDKKKKRINSGQHIHGVYTEDCFDKYFLINYKNKVFDFIESAIETITLEDIADFVNMEKILRINGFKYNFSSLSENNDYADRKSGSIPLMVFKNCYGIKEIANNLDEKLNDINITENNCFEGTETRSTSALKQELIVFLNSDDEEGLIFGPCEPIPPIGVEYEYENNSSGSCYVTKAELEDTIYKVKYDMKLLLTYKVISRVSLDKNLHSDEYAFNNNINDDDNHQHMNTNSQNEKGKIIPFHDGKCKNGDSFSNEYEDIDKKECINSKTEDSEAMIKKKNIKNENKTEDVEVKKYNFTKDIKDNERKRKKRISFKDNILRKSKFIAAFYNFDKKKDDVGKEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3H1</accession>
    <name>A0A0N5B3H1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3H1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3H1"/>
    <dbReference type="WBParaSite" id="SPAL_0000062300.1">
        <property type="protein sequence ID" value="SPAL_0000062300.1"/>
        <property type="gene ID" value="SPAL_0000062300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000062300.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24542" checksum="82F8545CC084ACC3" modified="2015-12-09" version="1">MNRIFGTGKPKAPPPSLNDAVGNINARGESIEKKISKLDGELVKLKDQMKKMREGPAKNSVKQKALRILKQKKMYESQKDQLDTQAFNMEQTNFALEGMKDAQNTVAAMKHGVVAMKKEFKKINIDKIDNLHDEMEDMLDMHNEIQDAMSRQYDTPDIDENELEAELEALGDELAFDEDTSYLDEALNAPKVPSTVPSAERKTEDGIAVDEFGLPKISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3J2</accession>
    <name>A0A0N5B3J2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3J2"/>
    <dbReference type="STRING" id="174720.A0A0N5B3J2"/>
    <dbReference type="WBParaSite" id="SPAL_0000064500.1">
        <property type="protein sequence ID" value="SPAL_0000064500.1"/>
        <property type="gene ID" value="SPAL_0000064500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="590"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000064500.1"/>
        </source>
    </evidence>
    <sequence length="802" mass="92217" checksum="182CF1BE45D11ED2" modified="2015-12-09" version="1">MSDREEISSRDSFSEEFSLREDYSEGIALWDLSTEARELKREKQKLLRKERAKKRLARFDSILSDKGKEIPEASGESFKSIEKVVEKVNQLTITSTETQVEAKNMVDYFRNIEIYKDTKVSIDKWLRRFEAAVKLSKIIDEDEKKTTLSLFLEDEAADFVEKIENESFAEICRKLRERFDSHESARSAEAKLCTFKLDLRDHGNVETKLLELIKLVKDSMPMSDEKKIDFEQQQVHRSTIKDYDKAIHLIRDVAIWNVQYQERREFRENGRNKNRSNRPSWKGEISDNRVVNVDSKKRNPAVKLVCYHCKEEGHKKTTCPKLNNRSTSSNSITVSANGIGAVNEKRKIKFHEPTPAEWEEINSAYPAVSDLIYTEVNLRGSDNEVHTILGMIDSGSQATIVRDEIVKQLKLDSLVRRSNFKIKGFFFNEQVIVKSEITLELSISNEKAIMTNAVIIDDACMDTNLDIILGVTLKDYVKDIVNCAILKGEVDGNNKVKLVKCCKVMVQQQMNKLEMDFINEAVICDIEKKMPDVRSLFSKNAYDIGLCNLTPNEEGFRIYEEKLFDVNTKAYKTPRHLVNVGFILLDELVKSNIACEDITPTFVSNVLLVQKCEIPDDLMNDRETILKSFRIVIDLRDLNKITIPIPFCSESVEDIIYKTYDSRETTPKIFSSIDLSQSFYQFPIPECKQKLFGLRFMGRVLTLLRLPQGYKNSPALLTDVLRRAFLNFDIPGSSLNWYIDDSLLSSVTYENHIDALIVLFKTLKSLNLKVNIRKSTLARETVKMLGHELHGRNNSVTPSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3U3</accession>
    <name>A0A0N5B3U3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BH4_AAA_HYDROXYL_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3U3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3U3"/>
    <dbReference type="WBParaSite" id="SPAL_0000074500.1">
        <property type="protein sequence ID" value="SPAL_0000074500.1"/>
        <property type="gene ID" value="SPAL_0000074500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000074500.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27656" checksum="1E3AD9A442AA4043" modified="2015-12-09" version="1">MYNIFIAKTGFKIRPVAGYLSARDFLAGLAFRVFNCTQYVRHHADPFYTPEPDTVHELMGHMALFADPNFAQFSQEIGLASLGASEKDLANLATLYFFSIEFGMCGCYSSDPEDSENFVENEENNLNKNRNLKVYGAGLLSSAGELSHAVSDKANILRFDPDRVVKQECMITCFQTAYFYTKNFDEAQQKLRMFTNNMNRPFIVRYNAYTESIEVLNNNRSLTLAINQLRSDINLLASALHSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3W4</accession>
    <name>A0A0N5B3W4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NARG2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3W4"/>
    <dbReference type="WBParaSite" id="SPAL_0000076400.1">
        <property type="protein sequence ID" value="SPAL_0000076400.1"/>
        <property type="gene ID" value="SPAL_0000076400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000076400.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="55258" checksum="028B34FD2987EB7B" modified="2015-12-09" version="1">MSSIDIMNKFMENIKNACGDEKCIDENFKFLNDEIKKGNARIGKKDVKDIITTFYKETSKFPELNKFWSNYTNILQYNNKEVRRILVCNLVQRDVENGIPCPYRVLEIVFQDRELVKLINSPQTYIQAALQVKDLSPNHLNLLGGDSVGGRIFRKELENLFMHKWKTLLCSKNAEGNLKAIEDVFEYIKIIRKNLNKVANEDIIANFNNFGKVCCNLNIYTCASSTTKELSNHNKVMEKPSFLNYEKLLKDYSRGMVRKEILYELLYEIYIYENKREELLSYLKSRYNNIYYIFKDLKYKSVCETGFIPDQITRICMSRGYPSTIIKPQFQTEYYSLEKSKLFIECDPNTCVKNCDKKSHTKWFKINFVEGSELSLNVVEELKDLAKNGQNQTLFLDVKSLCYLATSYDYDESESFPYSYWQRKSLREDQRKEMATRLLALYDIYSALGSAMRKNPEYQKYADPITQVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B578</accession>
    <name>A0A0N5B578_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B578"/>
    <dbReference type="WBParaSite" id="SPAL_0000122500.1">
        <property type="protein sequence ID" value="SPAL_0000122500.1"/>
        <property type="gene ID" value="SPAL_0000122500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024">
        <property type="entry name" value="BIOFILM ABSENT ON HEAD (AFTER YERSINIA EXPOSURE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000122500.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="55070" checksum="0C0B1A24E68ED3AA" modified="2015-12-09" version="1">MVSFEEKYNSDYEYIKDFRSKKINFSNFKYSKNVSEHSLILINLHLIEKEISPNVFSHFIHAFGFAKCISKYNNNDTTTLILYEKKRNLYIVGNITTIANGCPWTWANKCEWNSFHVSFMISSKIVEDISDVTIYNFHTSVKLDVTIKRTLNHEKKKDNLTICVPPLYWYDNFLQLFIFTEIWKLHGASHFVYYYYSVSEDVMNLLKYYESKNILTIVPLKSLPKSKMVDPNRSIYRYGHLAAINDCLQKRNSRYATVIDVDEFLYFNDSLYSNKKNFYQHIDEIFLRNKELSGLLFSHHGLRIDTKNMKEDFKFLQNSYLNTYTGPKKYIIKPNRVDTVDSHRPLKHMNYTLKRMDFNDAFLLHSRSNWANKNSKLDKKVKLISLDQTRKISDQFSKIRKKLNFIKDFDFQTNTLNIMNKCLSSWKKEGCKVPDDLCQKELSNVENWIKSDDIDTNEHYYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B584</accession>
    <name>A0A0N5B584_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B584"/>
    <dbReference type="WBParaSite" id="SPAL_0000123100.1">
        <property type="protein sequence ID" value="SPAL_0000123100.1"/>
        <property type="gene ID" value="SPAL_0000123100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893750" evidence="1">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000123100.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34770" checksum="1CE78E67B1DAB995" modified="2015-12-09" version="1">MNYRFLFIFFHLLILLNIIYHNSVVCEEKLLQVNTFSDLLKGGLNGGKKIKNNDKTVPEVVEESEKLEEEEKIEEKNPLIISDNNFPPKYNVFCVPNSVSLKDRFCYGNLDAYIIGCAHNNYPLHLASFCFGFKHLCSKVNFPNDGFCDKEYEHYSKFCKIDDRDSCSLDTKVYCDYANGNGTRDDEVSRLAYGCFCDPYKCLIRRGGLHTANWCQRYELFCDSKKREEESQELSQLITKAIVVHQHCTIFLHFAKVLCNPFGPDYDEKRCTKFLFDCELITDFTKSEGLKSTEVKLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6F1</accession>
    <name>A0A0N5B6F1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6F1"/>
    <dbReference type="STRING" id="174720.A0A0N5B6F1"/>
    <dbReference type="WBParaSite" id="SPAL_0000164100.1">
        <property type="protein sequence ID" value="SPAL_0000164100.1"/>
        <property type="gene ID" value="SPAL_0000164100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF33">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="16">
        <location>
            <begin position="237"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="14">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="14">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="14">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000164100.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52464" checksum="957A7B7A8CBF3346" modified="2015-12-09" version="1">MSYELLDALMQKDVVKLGDFVLKSGLKSPIYIDLRPLISTPNILSLAASALVDLIKESNVEYDYIVGVPYAALPVATLVCEKLNKPMLMKRKEVKSYGTKKLIEGIYKSGGKCLIVEDVVTSGMSIQETVDALKNEGLICEDVFAVLDRQQGGCQNLKKNGILLRTCVNMENILDYLMDKNVIDNNKKDDIKRMLSNPEKHIPDKHIVSWDMSKRQSLFNNLLNKKIFDIMLKKKSNLCLAVDYTTTKDIMHIVDIVKDDIICLKLHCDIIEDFTKEFVKTLSTIADKHNFVIFEDRKFADTGNTVELQLSKGVHCISEWANLVTVHSVTGDSILKTVKKVMDHSESKLEGALIISELSTKGALINEKDYTDKTTKMALENVDSVSGFITQKRPLDNPSFLYWTPGVNLDASSDGAGQQWRSVEKAIVEDGNDIIIVGRAITGAGSDENVKKQVIRYKESGWKAFSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6P5</accession>
    <name>A0A0N5B6P5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Damage-specific DNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6P5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6P5"/>
    <dbReference type="WBParaSite" id="SPAL_0000173200.1">
        <property type="protein sequence ID" value="SPAL_0000173200.1"/>
        <property type="gene ID" value="SPAL_0000173200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="13"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="442"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="851"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000173200.1"/>
        </source>
    </evidence>
    <sequence length="1205" mass="135344" checksum="D9E390FC43074290" modified="2015-12-09" version="1">MFLYNLTLQPKTVITHAISGHFFGNSKQQEICVARGSTLQLLLPDPNTGKLVTIYSQECFGIIRNLMAFRLTGGKKDYIIITSDSGRIGFLEYIPAKNIFQIVQMETYGKTGIRRAVAGEFIAVDPKGRCVMIASIEKQKLVYIMNRDSEAKLTISSPLDASRTQTLCFGVVGIDVGYDNPTFAALEIDIEEIDNDPTGEKLKEYKQNLVYYELDLGLNHVVKKCSEPLDDLVNLVVSVPRGVDGPGGVLLCCEGKIIYKNIIEGLESSIQIPKRKFALDDEYSSSMIVNCVSQLKTKGAMFFLVQFENGDLFKLTITMTKKNPILELTYFATIPPASSITILKTGYFFVACESSTARYFQITKLDDTDGEKFLSTDEDNENFYTPKQLSHIYEVDRLNSLNPLMRLKVADMINEGSPQFYALCGSGPSSNLKILRNGLPIREVAVCQMPGTPTGVFSVKKSLDDIHDAYIIVSFVNATLVLKIGESVEEAVDTGFFNGATTINACQFGEDSFIQVIPTGIRHITVNQRINEWVCPPRKTITHAALRNRQVVICLNTNELIYFELDMYNQLNEYNEKVQVDHTVLSMVLSPIPHGEFRSRFLAIGCGDCTVRIFNLDPYDCLKQITMKLLDSRPRSLMFVEYETDESDYRSTYLNIGMDDGFLMRCSIDPVTGDISDSRKRHLGTRPVKLSKMYTSGKDALLAISNRMYLNYMHQNRLYMNPVSYEVLEFADGFSAEGIKEGIVGIGGDKLYILCPEKLGETFNQISFKLQFTPRDMVYHYAGTMFIVEADSSILSQNKSKEHKKEVIKSILSLPEIDEQTLPLQYIEFLKGNDMPTEEYGYERTSDGEWASCLRLLNVRTGETIKRLELDTRDAAFCCTFVEFLQHPGAHFVLVGCATGLKFNPHTNSGGAIYTFHITDGGHNFELIHVTSTEAPVYAITEFKGHALVGCGKSIRMYAFGKRKLLKKCESRNMPVNVVKIATIGQRIIACDSQESVHFMRYIQKDNSIVTFCDENSPRYVTAIAVLDYDTVVVGDRFGSIAVLRLPEGVLDEADEDPTGVRAIWQRGAMNGASQKVDVIAHFFVGDAVTSLELVHILPGAEKCIVYGTISGSIGILVPFLSKNEFDFFQALEMYMRRDFVSICGREHVSYRSYYAPVKNIIDGDMCEQFNLLERLKQCDIAENLQKTINDISKKLDDIRTRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6W3</accession>
    <name>A0A0N5B6W3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B6W3"/>
    <dbReference type="WBParaSite" id="SPAL_0000179900.1">
        <property type="protein sequence ID" value="SPAL_0000179900.1"/>
        <property type="gene ID" value="SPAL_0000179900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053224">
        <property type="entry name" value="Sensory_adhesion_molecule"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31460:SF3">
        <property type="entry name" value="MESOCENTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000179900.1"/>
        </source>
    </evidence>
    <sequence length="1543" mass="166253" checksum="9C6616BB3AFB53A3" modified="2015-12-09" version="1">STTGKYVTKLGDEVPVDSYSRPLGPDGQVLPTDDEGNYVYPATDRDNNILPTDTSGIPVYPIVDKDGQLYPTSSTTKQRVDESGKPIPTAGRTGVPVDESGTPLPTDEYGIYVYDKEEQTVVPTDVYGRPTYEITGPDGQPLPTSTSGKYVTKLGDEVPTDSSKRPLGPDGQVLPTDDKGNYVYPATDSDNNILPTDTSGIPVYPIVDSEGQLYPTSSTTKQRVDESGKPIPTSEGTGIPVSKTGQPLPTEEPGVYVFDEEEQTVVPTDIYGKQIYEIIGIDGKPLPTSTTGRYVNKLGEEIDLDSENRPLDPEGNVLPTRGTDQFVYPATDSQNRILPTDISGVPVYPIVDEDGNLYPTSRTTGARVDDTGKPIPTVEITGIPVSESGQALPTEESGVYVYSKDTSEEALPTNAYGKIVYPIVDKDGQLLPKNDDGDFIDDKGDVIKTTEDGTPLGPDNEPLKKDDKGNFIYKPEVSPELAGQTLPTDVYGEKVYEIIGPDGEPLPTSTTKPEVSPELAGQTLPTDVYGEKVYEIIGPDGEPLPTSTTGKHIDKLGKEIELDSSRRPLGPDGQVLPTDDEGKYVYPATDSENNILPTDTSGIPVYPIVDEDGQLYPTSSTTGQRVDESGKPIPTSAKTGVPVDESGTPLPTDSTGKYIYETKPDEGVIPTNVYGKKVYPIVDEVGNLLPKNRDGNFVDKDGNVIRTNDEGIPIGPDNQLLKKDDKGNYVFKPEAELEGITLPTDADGRPIYEIIGPDGQPLPTSTTGRYIDKLGEEILLDSSKRPIGPDGQVLPTDDSGNYVYPATDSQNQILPTDTSGIPVYPIVDSEGQLYPTSRTTGQRVDESGKPIPTSPKTGIPVSKTGQALPTDESGAYVYETPISEEVYTTNVYGKPVYPIVDEDGNLLPKNEDGDFVDKDGNVIRTNDEGIPIGPDNQLLKKDDEGNYVFKPEADLEGITLPTDADGRPTYEIIGPDGQPLPTSTTGKYVTKLGDEVPVDSYNRPLGPDGQLLPTDDSGNYVYPATDRDNNILPTDTSGIPLYPTARTTGERVDQSGKPIPTSPGSGIPVSKTGQPLPTEESGVYVFDEEEQTVVPTDIYGRTVYEIIGLDGQPLPTSTTGRYVNKLGEEIDLDSQDRPLDPEGNVLPTRGTNQFVYPATDSQNNILPTDTSGVPVYPIVNEDGQLYPTSETTGARIDESGKPIPTVEITGIPVSESGQALPTEETGTYIYEKVPSEEGFTTNVYGKIVYPIVNEEGQLLQKNDDGDFIDEKGDVIKTAEDGTPLGPDNEPLKQDNKGNFIYKPETSPDMVGITLPTDIYGEKVYEIIGPDGQPLPTGDTGRHINKLGDEIPLDQSSRPLGPDGQVLPTDESGKYVYPATDRDNNILPTDTSGIPVYPIVDEDGQLYPTSSTTGARVDQSGKPIPTAAKTGIPVDQTGKPLPTEDIGIYIYPTTSPEALIPTNIHGKPVYPIVDESGMLLPKNDEGDHIDKEGNVIRTNEQGIPIGPDNQLLKKDEHGNYVYKPETELEGITLPTDEYGVKEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B855</accession>
    <name>A0A0N5B855_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B855"/>
    <dbReference type="WBParaSite" id="SPAL_0000222800.1">
        <property type="protein sequence ID" value="SPAL_0000222800.1"/>
        <property type="gene ID" value="SPAL_0000222800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000222800.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15382" checksum="97B02505500269C1" modified="2015-12-09" version="1">MDYRKNLFYIIIFLVFCCNIFAQYQSPTYGYPGSQPYDKRPQVNVVRTQTLTTYNAPNAGYSNGNYGPSPRESYNSHYSRYYQNRGFSYGQYGPNRYGSHSYLPYRGYPMVDSKDRAVMGLGLLASSLIGKKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B867</accession>
    <name>A0A0N5B867_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B867"/>
    <dbReference type="STRING" id="174720.A0A0N5B867"/>
    <dbReference type="WBParaSite" id="SPAL_0000224000.1">
        <property type="protein sequence ID" value="SPAL_0000224000.1"/>
        <property type="gene ID" value="SPAL_0000224000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF277">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000224000.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="35847" checksum="914A41D9B75917D3" modified="2015-12-09" version="1">MTLTTATCCAIAASGLTLLVCLLAISNVYNDVQSIWAEIDREIDTFKSQSTDLWGDMLKLGADTPAHRIRRQNYGGYAASQPVEAPRVTQVCVCQAAPASGGGSSGSGSGSGSGVPNGASADSAFDYTKDTSGGHCPSGPAGPPGEPGANGIPGIPGKDGKHGLDAESVKNTPTTGCYTCPTGPPGIPGPVGRPGARGPRGPRGTPGNPGFDGLPGECGEPGPDGAPGPDGEAGPPGLKGQDAEKIIGRKGIPGPPGDVGPAGDEGEPGDDAPPGPPGPPGPVGAEGFIGPAGIDGDEGVRGDQGKPGKDANYCPCPPRGQEKHQQTHRKTASKTSAPHGVNSASYNAGPEYKTGYDSPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B883</accession>
    <name>A0A0N5B883_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B883"/>
    <dbReference type="STRING" id="174720.A0A0N5B883"/>
    <dbReference type="WBParaSite" id="SPAL_0000225600.1">
        <property type="protein sequence ID" value="SPAL_0000225600.1"/>
        <property type="gene ID" value="SPAL_0000225600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000225600.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38030" checksum="675AA676F96A04F2" modified="2015-12-09" version="1">MQENLTNGSKNNEEKNSLMIIKNKSLKELPTKNILIKLLKWQNEILAKYASKINEFYVVPLIKHSTRPPLKSLIKSSTNEPVQKNELNDDLSKRDNQFKAKIKELTLDLSQSTEFYIPVQKQRWMSVGELSVLHRIKILTQMIGSFSSMKDFQISIIEKYYDQLVSKKDSNIATLIKNYLKGLWSCVLIPDIFSLDMINYASIDKEIIKYLPESLFKQRKNSTVRNQSVKINYNNPTEYVRELEVQINCLRTIVHLVIKPMIDLSDQSFCLSNDSKKILQSFLMLKKIYNNLPNKYYFLETHPLYKTYIELLNESPDNNGIIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8F8</accession>
    <name>A0A0N5B8F8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MoCF_biosynth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8F8"/>
    <dbReference type="STRING" id="174720.A0A0N5B8F8"/>
    <dbReference type="WBParaSite" id="SPAL_0000233100.1">
        <property type="protein sequence ID" value="SPAL_0000233100.1"/>
        <property type="gene ID" value="SPAL_0000233100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051920">
        <property type="entry name" value="MPT_Adenylyltrnsfr/MoaC-Rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764:SF1">
        <property type="entry name" value="MOLYBDOPTERIN MOLYBDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="4">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000233100.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20704" checksum="F5C0EBDCF8EE3A46" modified="2015-12-09" version="1">MDCQKCEDQLKLDKNKGKFKAVVLVASDSCSTNSNEEKSGKRASELIVQKLGRTIYNIPGVVVSSDEKEELINKMIHLVDVEGYDLILTVGGTGWSPRDNTPEATKIIIDKECNGLSQALINKSLEKTPMAALTRLTCGIRKNSLIVNLPGKLKAVEECFEILENIINHGMDVLKNNLSEVNNLHGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8R3</accession>
    <name>A0A0N5B8R3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8R3"/>
    <dbReference type="STRING" id="174720.A0A0N5B8R3"/>
    <dbReference type="WBParaSite" id="SPAL_0000243600.1">
        <property type="protein sequence ID" value="SPAL_0000243600.1"/>
        <property type="gene ID" value="SPAL_0000243600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000243600.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53407" checksum="C83F94BBA58E00BE" modified="2015-12-09" version="1">MITSAGNYVFISFASLKPTCEASTLDKTQLENPCYLLENCPQNQTKYYFFSLYQEENFICPDYVNAPYQLQTLQAIGSGTGAIVGGLLADKYGRKWITYIGCVVMITSGLVGGFSSSKNVLALAMLGMGSSYGMLIDASMTLASETVGPKYRLIQMLAFQWSLALQISSVIAYFTGEWRRYLITINTLAIPLLLLLLSWVESPRWLIQRRRYKESCEAINKINKWNGCNVTFTPNDLIGIKTQSEENKSKTFFVHHLVSTVKLAKYSIVLFLSALTVELCIAVFLFDVQVLNGNPFINIGLYGLLRVWVPFFIIILERTPFFGRRSLFLGSQSFSIICYSIVFMLTYFTMPKYIISLPTIKTIFALVGGIINSSIFFTIYKQYTMELYPTLLRAIAVGTFGLVERIGGGLGPQLIILNNIIGKGSAIGITIIIMTLSLITGYFFLPETKDKNMDDFCGLEEGISLEGPDNLLSSCKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B901</accession>
    <name>A0A0N5B901_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B901"/>
    <dbReference type="STRING" id="174720.A0A0N5B901"/>
    <dbReference type="WBParaSite" id="SPAL_0000252300.1">
        <property type="protein sequence ID" value="SPAL_0000252300.1"/>
        <property type="gene ID" value="SPAL_0000252300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="236"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000252300.1"/>
        </source>
    </evidence>
    <sequence length="691" mass="80000" checksum="3E0A8E9EDCD8AB8B" modified="2015-12-09" version="1">MVENKVAENTGKNSCCSHVSKFKKNDNSMNCDGVTTSVNKDEKTILLEGGNYVGFEDKDKKKVDDDPLKLNCKNNTLNISKTTENSRNSRKSVKKRHLKSFIFKHHSTGQKTHNSRKKKIHNPVKTRSIHLLSYFRNYFTNPGDFLVHLDQVDSELKYFLVLLNSDNKIEVHTIENESGQYYLNSVGKYHKIIPTFKAIPHLIDYYRKHHIYDRSILKCKLKRPSHYLNQSSITYDPKNGIIGQGNFACVYKGTLAEKKYKELSIAVKVFSLSIENDTFENITERLLKILNEARIMKNLNNQHIVRFYGISLDKYPVSIVMEICLGGSLENHLKTEKDKISVAERLFYCYDILDGACYMSSHNIVHRDLAARNILISNDGYLKIGDFGQALNLNTKQQSCMLKGKNKNVISLWSPPECLSNNSVAWSEKSDVWSFGVTSIEIFNDGQPPFKKEDACNVVSQLKKGVYFEIPKQCHEDWHLVLKEGVFIKEQTNRFNFKQLKELLKALRHNRIARLIYEELCRKYKLKVPKVNEKIPLLLENDEVCLRWNYTIPASTSIYHRKPDLYLHLKKEGKIFLIEVSVNALKNILRQRKLKLARYSVNGEKLLKFEEVDTVKAGNNIKKDLESRMKCSVEIIPIIVGNLGEWLMEFDVYLEKLKLDVRMKQRMSAISIHTANRIIKRHLCVAPEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9A2</accession>
    <name>A0A0N5B9A2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9A2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9A2"/>
    <dbReference type="WBParaSite" id="SPAL_0000261800.1">
        <property type="protein sequence ID" value="SPAL_0000261800.1"/>
        <property type="gene ID" value="SPAL_0000261800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000261800.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42721" checksum="743807732C53309C" modified="2015-12-09" version="1">MSMNYDVGLQVQANFTINILNTLINSNEDVAFSSYTLTLALAICYLGSSGITEIEFKKVLSPPYMMKGDYCEMLGDSFANIYGSGRGGDGIYIGNKLFFQQDYAINKIFKLETEKYFKTTFESVDFENSTFTAQKIYNFIKKSSGAKSHNTIKSDNIISSKKGIITNAFYFKGLWKESFNESLTSDGEFSTKNNKKKIVKMMKKMDTLIYGNDKNFHVVRLPYSNGNSEFVLILPKEDNMLHYYLENLKDKDLLNLIDLTYYEYVDLVMPKFTVEVSHDFKEPLIKLGVLSAFNDKANFSMITKEDNFKIDYISQKVSVDVNEEGIESDEMTHLWHESTSNVSSGNEPIVVKADHPFLYLIINENNILFAGIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9A8</accession>
    <name>A0A0N5B9A8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9A8"/>
    <dbReference type="STRING" id="174720.A0A0N5B9A8"/>
    <dbReference type="WBParaSite" id="SPAL_0000262400.1">
        <property type="protein sequence ID" value="SPAL_0000262400.1"/>
        <property type="gene ID" value="SPAL_0000262400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000262400.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30466" checksum="688DB1E900CF4D7D" modified="2015-12-09" version="1">MVCDVGVGFCLIAPIIYLLVLWLFDYNGTDRNCLSSVIRRVTGALFCNVAFIIVVHFILSSNGRDSFFEMGIKKEGTIASFFVSPIPIICLYFGTIIMLGLDGVLKDIFTLKGWCDCLTDRIFIRNVVFAPVSEELAFRACCIPLLVHCFDKSTIVFILPLGFSLCHLHHILDDTRKGSSVINALLARLFQCTYSYLFGVYAAFLFLRTGNVIAPIISHAICNCLGLPSIFDINEYPDVSPKIILYCCHIFGLIMFIYLLFPLTDATLYQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9G2</accession>
    <name>A0A0N5B9G2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9G2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9G2"/>
    <dbReference type="WBParaSite" id="SPAL_0000267800.1">
        <property type="protein sequence ID" value="SPAL_0000267800.1"/>
        <property type="gene ID" value="SPAL_0000267800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000267800.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38632" checksum="B208C427CD9A5E5F" modified="2015-12-09" version="1">MQLFLVAFLYYLLSIGLTFFQKQFIKTFHFPLFIVAGHYLTKLLVGYISRIFLEWKRGGKKVRLPVKDQLYYLLPIGVCASFDIGLSNWALEYVTVSLYTMAKSSSILFIFLFSILLNLERWRTSLAMSSGLIAIGLFLFTWRSNQLDILGLVLVELAALCTGIRWTVSQLIMQQEESPTTIKNPIDMIVHVQPWMILAILPLAWVFEGNDIQSYNHPDITLPMIFVNIFFGGLLAFSMEVTEYALLLKTSGITLNILGIIKELITLLLAHYIHHDKLTTINGAGLILCITGMILHALTKQKKNMHLNRIGNASTNGEDEKRLLMSEIKKKKKNEQNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9P5</accession>
    <name>A0A0N5B9P5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9P5"/>
    <dbReference type="STRING" id="174720.A0A0N5B9P5"/>
    <dbReference type="WBParaSite" id="SPAL_0000276100.1">
        <property type="protein sequence ID" value="SPAL_0000276100.1"/>
        <property type="gene ID" value="SPAL_0000276100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="60"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000276100.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44642" checksum="1C999287FF794876" modified="2015-12-09" version="1">MMNLSGLTKLLVKRNFLGTINKATLKISASVLGVNDRDEFRSPIKSPSNIQFARYGGRYTITALPGDGIGPEMLEYVQKIFSFANVPVDFEECQLDSKPTSPESDLDTAITSIKRNGIAIKGNIETKYNDPIYKSRNVELRRRLDLYANVIHCVSIPTIPTRHKGINIVMIRENTEGEYSGHEHETVPGVVESLKICTREKLERISRFAFEYALAHNRKRITAVHKANIQKLADGLFLKIVKEIAEKEYSSINFDSMIVDNASMQLVSRPQQFDIMLMPNLYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDVANPTAFIRAGVDMLNFLGLHDYADLISDALFDTIVTKRMHTKDIGGTAKTSDVVNSIMHSIETLYESERYNSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9R5</accession>
    <name>A0A0N5B9R5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rac GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9R5"/>
    <dbReference type="STRING" id="174720.A0A0N5B9R5"/>
    <dbReference type="WBParaSite" id="SPAL_0000278100.1">
        <property type="protein sequence ID" value="SPAL_0000278100.1"/>
        <property type="gene ID" value="SPAL_0000278100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="300"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000278100.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60424" checksum="C962A85D1800B6AE" modified="2015-12-09" version="1">MYKESRSVDSISFLQEHIQLVSAYESLCATTNDGVLDAYEFTLSSCEETNSFKKEIEDIIDYCDKVVKKNKVLEVDVERYKEEIAMLKNRLSESEKENKHLKSCLESLRNTFADNKDKTKSETRDSNIVSTDSEDDIDFDKTDESAKSDEKKISLKQQTFTQEDGIKNRESLTSDTVTDSLKRSASDLPKRQPKYEKRDFNITVATENPLIIEPLKEYLESTSSLSWTNGSYISQRSHRFYTKGFHIGTCNICDSLLFKSKNVLSCSDCNLLGHIGCITNTSIPCIPRHSFPKIVNRIRLSLAECCPGSNPMIPYIIIRCLIAIEQFFLDHEGIYRVPGNPDSIQRLFISLKNPKTSVDLSKEFPETIVGCVKRFLRELREPLIPSSSWDEFTTAAQMDDLEGINIAFCDLPRPNADTLAFMCDHLQKVIKKSSINKMSLETISQVMGPIIVGYPNRGRRSEVITTATKERDFEKQIKTMKTLLSLPPTYWDPFLKPSSTRNRRSSLSRPISALNTLNNSVRYSLGANPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC28</accession>
    <name>A0A0N5BC28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC28"/>
    <dbReference type="STRING" id="174720.A0A0N5BC28"/>
    <dbReference type="WBParaSite" id="SPAL_0000357700.1">
        <property type="protein sequence ID" value="SPAL_0000357700.1"/>
        <property type="gene ID" value="SPAL_0000357700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000357700.1"/>
        </source>
    </evidence>
    <sequence length="982" mass="111346" checksum="46187177E06044B6" modified="2015-12-09" version="1">MNLSIDHNENIRSLQSKANYLGRKILNHPQIGGKKYETCYIHRHLPPHRLHNVLCSYRHMPPEENNYRPSNINKQRKVPKIPHIILSTSKVPSYPVRNTLTKNYVIKNGELQKKYSEEKIFNYTVNCMCNNKNKLKEENVNIKDLLKVKDEVEDDFSKFLNHYYKSLQLIGELEKTNTNQILREKKQENLCRNCFNKTCVNSPSVSKSIQYVVSHKKSEDYNSKKNINENHAKRKNARFEDVYKPKLEIEVPKLIDIGMDENVDEDVEDDEEEAEDYIWEDESISEMYRNSQKPIMPINQKIDTPINEANHYMDMAKHVSNEENNIYSKRTSAGISTIREIEEYVTNGKVGNNDDRLLNQYQTADRSFTEFVETPKQYLSTIDRNSNNSTSSNDTLVPSVHSASSLKVNSSNLKKWDNIKLVTESAVINNSSSSSSKKSSKTSNKSIKSFISPDNNNHKNIYEKTKEDVINYNKELHISKYQLTETTKNRMSLSYSNEIISQNSSSSKSIKKQEIILVGKSQRQDSILSSLSNNLNDNVSSKNDKFQRSPPSLSIISSQQLQQTNRNIQLVSSKNDISELDSLRSSSVNTFNGDELIDDNHIITSDNKSSLKSGNNSYEVKKITNEVSLSSLSSLTNQNNTPSSLDKIDTSSSNDKKKDIRKNNFSPSKNHQQSPHFSNMINEEPKTVNSTSSSTNLSSLEREEERTIKYDGKIEDKMPIYQNLKNSGKSKLISNLYGIEVSNNKEVNSTDVIATLDDISKSISTSDNNNLSNTQSLINAGNNIYLKEFDTKENRELKENANTSLNYKFNLIFNDKKMNENSSLKDESLLSDIPSISELENSIKNMRTDKNIKYENVIEKDDINEENGNLLSQNNMNNELNFQKSSLLNDIDNILNGDIDENNLSPLSTIESSNSSTAVKKLSNKSSSQLSNKSLSQLSSKSSLKSSKTSSSISTLLSKNLSNVSSSLSSLPSSATSLNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCM9</accession>
    <name>A0A0N5BCM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCM9"/>
    <dbReference type="STRING" id="174720.A0A0N5BCM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000377400.1">
        <property type="protein sequence ID" value="SPAL_0000377400.1"/>
        <property type="gene ID" value="SPAL_0000377400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894075" evidence="2">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000377400.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31146" checksum="DFFCD936C44B1E10" modified="2015-12-09" version="1">MALDNLTTILLVALCASFLMATDDNTKNDTASNYGSAPAQPYQAPPPFFPPMGFPPMFGPPVFPTLLDDHICDDRAGVLITNFEKDLVNNAPSGGYGGNGAYDPAHGPAPHHGPFNPFHMHGNSRRFMCADIAATDLHSCNVCCRIAPRIDRSIKEQDVYGVIVDTLQLAEPNDNNEGHTPAGSYRKKRYAGVGADPEIPPPVAPAPPDFVPKVPAKNLKCICCMPRRRTLLPVPGPFPPPPPPAFPIFPHFPQYPQFQPGYGPQGGYGQAPQNGYGQAPQPSYSQTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCV2</accession>
    <name>A0A0N5BCV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCV2"/>
    <dbReference type="WBParaSite" id="SPAL_0000384700.1">
        <property type="protein sequence ID" value="SPAL_0000384700.1"/>
        <property type="gene ID" value="SPAL_0000384700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000384700.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="63412" checksum="02C735A7A95EC454" modified="2015-12-09" version="1">MDDKLSILDILGVGIVRKQVLNKLYSFMDINNLTKSCKWINFYIYNDKIRRNMFCFTDFPKITIRVKDGNVANPIMPSLEDIEFRKDEESLKVLNEGENFLGEAIVKKDQILLYINNYIENVREGDYELFIRKFVQEMDINRPIRKTATILDFGVPSCNRHNIQYNHHMILYALSYMHHENITRVVVPTYSFMSDSIKYRELRHNIFNGFPKLHELVIYGSLLETDYTKLINNRSTFENILRELATKENATLVLVHLNREIYPVFNFVRMVMEMAERYNIKVKCDAESLIDPRKEIVSSNERYSFISIADIITSVKCSIGNPKIFINFMKNVQFLRNLETLDLSYRIMDIERSCKTNSDLDAGFISFKHCKKLRKIKLKLAESFDSNYGFKNDKLLNVIKFIISLMPTSVEILELWHVYNINEEFTGAINDFLPNIKVLRTFDVSYKDPECLGSFKNLQALLLCDNYPTKVPDTVKLLALKYLNKEDDDEESMFANQALLECYSKKFTKSLQDIDGTHIFFNNIGHWDMYKRAFWNIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD69</accession>
    <name>A0A0N5BD69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD69"/>
    <dbReference type="STRING" id="174720.A0A0N5BD69"/>
    <dbReference type="WBParaSite" id="SPAL_0000395900.1">
        <property type="protein sequence ID" value="SPAL_0000395900.1"/>
        <property type="gene ID" value="SPAL_0000395900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="123"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000395900.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="91188" checksum="563C3DAB594B5DE4" modified="2015-12-09" version="1">MSKNSRSFSQISKIENEDIHLDHKANLTEGPCPQYKNFNIENNKVEVNFDNKMQPILLQNNHNNNSETENASNKTKDVNESNLTVNDNEKKEPQIAPFDEWTKEKLKMNVESNHRVNTIGTENTSIVSSTKQGNIIKQHPSVTTKRNYASKECGAKVLLSNDEAEFKSAILNDKERDVYMRNPCEKAQQKFAVIELCETIVPTGIELANFELFSSGPKEFKVFVSERFPTTEWHQIGQFEMINNREIQRFDLIKTGLYVKYAKIELTSHWGKEHYCTLSMVRVFGISMVEEYEAEASAISIPPPPVSVVNSVVNKTVENNNPQSNELINKDINKSSNDDGGVKTLVDKVVNAVGSKIESILNTVMQNNGMTKKSLMKPESLTLEEQCTKCLINHAPAHSYELCYFYNYVIRVISRRNITKNTNMNKVVISRPLSVTSIRKLREHEKYVKMKKRQRRRLIFQKYITEKIKKEQEVSSIEKKIIIQNGGDHSLPAANMNYKESVFLKLNKRLSNLELNISLTSEYLSELSKRYVSQTSDNTKMHENTIKKSEDLIRRLMADFRFEIDEKINAMKSEILSFKKSIKNSQKVSYFDNSLSVTKPPVVVNGDCPTERHMLSSVNDKIWTTEQVLFVVVGTQVITIICIFLLQWFFSWLYSKKEDSKNVYEIEKIKSEIEMLKNMVLEGNDPDDKEILDVIDEVQPITMKKRRRKKKKIVLLDNDWDSAFDNPSHPSETPTPSELSVETERIPLTLCNENLPFQEKHNQLLTADGFQIHSNRKNSKIRKINASLIIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDW5</accession>
    <name>A0A0N5BDW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDW5"/>
    <dbReference type="STRING" id="174720.A0A0N5BDW5"/>
    <dbReference type="WBParaSite" id="SPAL_0000419300.1">
        <property type="protein sequence ID" value="SPAL_0000419300.1"/>
        <property type="gene ID" value="SPAL_0000419300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000419300.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43393" checksum="FB001B298A410E7A" modified="2015-12-09" version="1">MQNQHIPMQQMRFNIPHHNVNNQGMLNHGNFGQQGGQCIPGQEAFLGNFNRAENRTLWMGDISPYWTEDIVKEIFNKIGIKVESIKMMNDISNGKKNGYAFVKFFSADIARNIMLELNGTPMPDIKPQVNFNFSFANSNSNSGAEFNILVSDLPPDFTDAELFKLFGSRYIGCRGAKILRNEDGSSKCMGFIRFSSEEEQTRAFIEFNQTKIGNHTMNLRLPHAGRSNNKHKPNESFQMPSFHREPSTKTNDFDRKRPFRYDKSYGLEDKRYHVAFKHTKGDVIRPLEEHDPKVMNAKMNSLDSFFVEKRLRLRFNQDYFEMIDDGINEDDNGEQNESDCHTEIEDEDKIENVENNVEEIDEESIKEENEVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE26</accession>
    <name>A0A0N5BE26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000425300.1">
        <property type="protein sequence ID" value="SPAL_0000425300.1"/>
        <property type="gene ID" value="SPAL_0000425300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000425300.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11275" checksum="82D95EA94EA19342" modified="2015-12-09" version="1">XLLGFSNGQRISYSWRTQNGVTVYSFNGKEYSSLQAVMEAIKKQFPNVEFKSPNSGTSTNSGLGNRTPSSGNSKNNGGFDITPYKGNNTFSNMIFDKVWAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFI4</accession>
    <name>A0A0N5BFI4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="14">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFI4"/>
    <dbReference type="STRING" id="174720.A0A0N5BFI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000475000.1">
        <property type="protein sequence ID" value="SPAL_0000475000.1"/>
        <property type="gene ID" value="SPAL_0000475000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0140">cGMP</keyword>
    <keyword evidence="9 14" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="163"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="281"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="435"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="696"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="441"/>
            <end position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000475000.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="85418" checksum="4DEBAF8C159BE85D" modified="2015-12-09" version="1">MPFMKSTKTISISGKTLNIEEVQRLIPELENDIIKKDRIIHEYKCVHDTYRQRIKELEEQVLFFQAECDKLRSVLEQTTVSATSPHKGSSQKSSTEMLVDDLQNKTALSTIKQGDNTARAKKVAVSAEPALFNKEQNNTVLQHHPKSVSDKRLIREAVQKNDFLRQLEKEQVIEIVESMYEWKVPPGEWVIREGEPGERVFVVANGMLRVTKEGKILRDIGAGNVIGELAILYNCTRTASIQAITEVQLWVLDRSTFQMITMKLGIERHSQMINFLKKVSLFSNLNEDRLSKLADVMDQDYYPGGHYILREGEKGNTFFVINSGSVRITQQIDDEPEPREIRIMGPGDFFGEKALLGEQIRTANVIAMNPGVEVLTLDRISFLNLIGELEALKRDYGDNERRRTHKEKRHPSNEMLNRERCAVMNELKDLQLKHLKRIATLGVGGFGRVELVCINNDKSRTFALKAMKKKHIVDTKQQEHIFSERNILFDLNSDWIVNLYKTFRDSKYVYMLLEACLGGELWTTLRDHGHFDEFTARFYIACVLEALDYIHSKNIIYRDLKPENCLITASGYIKLVDFGFAKRLSSGKKTWTFCGTPEYVSPEIILNKGHDRSADLWSVGIFTCELLLGRPPFQASDPMKTYTLILKGVDALDIPNKRMGKAATTFVKKLCKDNPAERLGIGVGGINEIRKNRWFMGFDWEGLRSRTAKPPILPRIENPADHRNFDSYEVDNDIPPDEFSGWDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFJ7</accession>
    <name>A0A0N5BFJ7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFJ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BFJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000476300.1">
        <property type="protein sequence ID" value="SPAL_0000476300.1"/>
        <property type="gene ID" value="SPAL_0000476300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="44"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="240"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000476300.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="74862" checksum="343B5E394076EA74" modified="2015-12-09" version="1">MFKCKDFQNPQNVDDYTGNSGCTLTSVSKQSSRLPIFKYKKNILYLLEKYRCLVVVGETGSGKSTQIPQYLYESGWCSDGRNIGITQPRRVAVVTLAGRVAEEMHTNIGDLVGYKIRFESACSDNTKIKFMTDGIMLRELTSDPLLVKYSIIIIDEAHERSTTTDVLLGLLRKVMTIRNDLRIIVSSATLDAELFKNFFEENETDDKSKDTATILSVEGRNYPVDLYYTKEPVPDYVVASVRTCIKIHKNYGNGDILVFLTGIDEVNDAIELLTEEAQSARISRELWILGLYGGMPMNSQMLVFETPPYGKRKIVFTTNIAEASITIPGISFVIDCGFVKTRMVVNVKSGLEQLVTLPISKASAEQRSGRAGRIGVGKCFRLYTKSNFDKFELDSLPEIQRIDFSPVILLLKNLGVSNIVRFKYISRPKADAVAAAFSQLHSLGAVDDLGNLTDPIGIRMAGLPLSPMESKVLIESGSFECSEEIASILAMLQIEEPFIVSKNKNQRIELIRRKFCAQEGDHLTLLNIYMSFVKNKKSREWCHSNCLNYGSLMKAVTIKDQLISYLKSYQIPIVSCQGLIGETERILRCLVSGYFLQAAFLDHSGLFITVRENISMNVWAGSSIIYRDKQPKWIIFGRCMAQSIRDISEIDMEWLMETGVFEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG25</accession>
    <name>A0A0N5BG25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG25"/>
    <dbReference type="STRING" id="174720.A0A0N5BG25"/>
    <dbReference type="WBParaSite" id="SPAL_0000493300.1">
        <property type="protein sequence ID" value="SPAL_0000493300.1"/>
        <property type="gene ID" value="SPAL_0000493300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000493300.1"/>
        </source>
    </evidence>
    <sequence length="53" mass="6433" checksum="9889A778971892A1" modified="2015-12-09" version="1">VDVQLRWKDYDLQLRWKDYDLHDIEGYSIGEYYDYTSNDMSVYTSLCSMLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG34</accession>
    <name>A0A0N5BG34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG34"/>
    <dbReference type="STRING" id="174720.A0A0N5BG34"/>
    <dbReference type="WBParaSite" id="SPAL_0000494100.1">
        <property type="protein sequence ID" value="SPAL_0000494100.1"/>
        <property type="gene ID" value="SPAL_0000494100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paired" evidence="3">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000494100.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41896" checksum="BFFE89EEF7F7A546" modified="2015-12-09" version="1">MSSSNSILMEESSVVSAETTQRTTYQDISNDDRNRLIKLVVDQGYSIKDASNMMEINYSSARTIISKFKNQNIISKKPKGGSIKKCLTPEIINEIEEIISENPSYTLKEIKRDIQNIRGSDFQISLSTIDRCLRELGITVKKSHRELDRVNDPDKIRQRKEYALWFNNYFNNDYSKIVFVDESSFHLHIQRTFSRSKKGTRSNVKVPTIRGRSVTLIASISISQMCHCKVISNSTVDADIFSEYLEELCMYIRDEMKLQAACLILDNARIHKRNEIERITSMFNFDFKFLSPYSYMLNPIENAFSKIKNCVRSRLRNNDNGVLSDVIMSEINNITSTDCNGYFRYITKNITNCAAELPYYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG97</accession>
    <name>A0A0N5BG97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG97"/>
    <dbReference type="WBParaSite" id="SPAL_0000500600.1">
        <property type="protein sequence ID" value="SPAL_0000500600.1"/>
        <property type="gene ID" value="SPAL_0000500600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000500600.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31451" checksum="0D9B9FE2E9C52A09" modified="2015-12-09" version="1">MRILDNKYFKIITKSPYHISRSSFTRSLEDHATKLRQYLASLIPKSWCLTLDGWSKGDLKIYAYVASFLSPTGPQQYLLDVFHVKKSRTMDIKKTIDYLVTALQSCLDDLESEILEDPKQSESSDTGSDDNDCSETDFTSNIVSQEDELSLSSSDNESGNEGGKGGYKRKKKYGFISVDKSSIESLKNNAKKMFVGEINLIKLSNFYKKAAYLDPRTTYTQLYTMETWCEIEKEISAEFVEISDAKKNDKQKNDEKTLFGPKKLNINKILKMRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGD2</accession>
    <name>A0A0N5BGD2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGD2"/>
    <dbReference type="WBParaSite" id="SPAL_0000503900.1">
        <property type="protein sequence ID" value="SPAL_0000503900.1"/>
        <property type="gene ID" value="SPAL_0000503900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000503900.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18694" checksum="6216B879374D2D39" modified="2015-12-09" version="1">MSDTFSLYNELLKTYLNTFFLLNIFNLLLVFLENKMLSIIIVIYFLSMVFGQEINLDYNESLCSRNQISCPPMEVKVTIMRDIFDILDINKDNETDFDEIFNSQLKPLNIKDSNAIINGKKYGERFYSLLKWIQKMDTNKDGKVTWVEFLSKHNEIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGF0</accession>
    <name>A0A0N5BGF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGF0"/>
    <dbReference type="STRING" id="174720.A0A0N5BGF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000505700.1">
        <property type="protein sequence ID" value="SPAL_0000505700.1"/>
        <property type="gene ID" value="SPAL_0000505700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47364">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47364:SF2">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018779975" evidence="2">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000505700.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17124" checksum="DA66A8DED885E7AA" modified="2015-12-09" version="1">MKYFFFFILFANYLIKTKGNFSLGAWTPIDTTTENVIDLAKKAVEKFNFEENEEVEFSGVSNALQQVVAGMNYKLIIKTTLKECPIKNKCIKYLEATIFEQVWTNTLNITVEALPPVTTETPTRSIYKSIHLETSVEEYIKSFYSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGH4</accession>
    <name>A0A0N5BGH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGH4"/>
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    </dbReference>
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        <location>
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            <end position="374"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK00</accession>
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        <submittedName>
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        </source>
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            <dbReference type="WBParaSite" id="SPAL_0000626600.1"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK57</accession>
    <name>A0A0N5BK57_STREA</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
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            <begin position="1"/>
            <end position="23"/>
        </location>
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            <dbReference type="PROSITE" id="PS50015"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000632200.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12800" checksum="6B2C27780AA54F9E" modified="2015-12-09" version="1">MYLQKSIILTLIYLIACLKIVENNDSFDKCLMCSHIIELAEQHFRNDEPQDFVLNELETECLYVGELDGGRTAVMYCINQVKQNIDKIYDDFKKKMTFDEICRQMGDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKL5</accession>
    <name>A0A0N5BKL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Macoilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
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            <taxon>Tylenchina</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="SPAL_0000647100"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031965">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="787"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="637"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000647100.1"/>
        </source>
    </evidence>
    <sequence length="816" mass="95241" checksum="534E90216C2D37A5" modified="2015-12-09" version="1">MIKRTRGEGIPKPKRSIKKVSKIEGNESCSLSFFQYIKLFLVWILFLSIDMLTGFRVELLWPFWLYIRNCCEKNNLNNNLTKYLKYPDLTFVFLIHIATVDLIFCLFVPVPFMLIVATAWVWTQYIYYSSDRSWSFMSGILITLSVLFEIYGRSKLETHVWSGKSFLAPNSLTIYTTKTDSYFEGTENMEYIGDINDDALSNSNTKDYFTFTVLDFCKPFAAHCISYPILCFIFSLFKYYYLWKEDRERKTIILKNTSIYDIMCDAVNSPKNSYDYRYKLTGINLETVTNYNNDKENYYLYDGDIVENQISKNNKNYENLPISAIMDTVTNEGSIKKFTASQKNNSCKSVRKQSKCNGKSNKNSQYNVNTIDKKDSSKESINSEELDDTDSISTASWSSNVEVVKDQLPIKNKKSGTLRNIYEFFCYLTMVSFQYISNVFIKNNDSDMLSDNSSLTSEECSEEEYNAQEDDFFQLGENGDGNKDCYSSRESPSSSGSIPLKENKKKIRQRGRDTENRKGEHSNSPLKSNGALNNGENILYNYNDNIRDNSKTSSYTDKENEERMELREETTRQLKESSEMIENLKLQLKKKSSVEKDLRSQLVKCEIAEKSSKAELTKIKLHYEQLETENTNINKYRDQDKITITNLEKKISELTSRKVELEKELKTEKQKLKELKQVDCNVTCKPRLMELENDNKKLLKTLASKNDSCEILIKRLEKIRAENDYRIELIEKSYEDRIKILNSDKERMQHTLSEETKFKQLLFKALLNAKEEAKYLKDYIIQKGYELPSPRKESDTDETTNNFYNPWTQLSDPPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLJ4</accession>
    <name>A0A0N5BLJ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLJ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000679000.1">
        <property type="protein sequence ID" value="SPAL_0000679000.1"/>
        <property type="gene ID" value="SPAL_0000679000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000679000.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14190" checksum="1341B1CD1E89BA6F" modified="2015-12-09" version="1">MYFLTSYQFIITQLFCIIISVSSINDCYYAWSERISPSSCSRASDCNSPTADCIFSLQVNQHICCAPKENAIFPECPAGMKIASIGSHNSILCEGEHDSDSCPNGYQCKESITNFDKHEGQSNFVCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMF8</accession>
    <name>A0A0N5BMF8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jumonji domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57156"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15084"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000709800.1">
        <property type="protein sequence ID" value="SPAL_0000709800.1"/>
        <property type="gene ID" value="SPAL_0000709800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="104"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="443"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="753"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="907"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000709800.1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="121408" checksum="EAE040355F39DF9D" modified="2015-12-09" version="1">MQRIKYTDRKETLRLFQEFMLQNKPCIFEDQFTKDWDAREVWSNDNETLNIDYLKKVYGNLECPVIINEHTSECVEMSFADYVEEYIFRGKYGYLKDWHFQSLCYKNGLDQVYKLFSILNFDWINNERWTTSSDDNPFGEDYRFLYLGTKGTWTKFHCDVMGSYSWSANIIGRKIWYFIPIGNEKFFVDNNSGDTYINDIRERRTLWKEAGVFEVVQNPGEVIFVPSGMWHQVHNEELTLSLNHNFINSANIELIYDLLKKRKVDVKKEIDDVISMNIYTNQEVNKIIENILKLDIKINFEMFYQLLEKVKNDREVFVKTFDANNIDNPLIDIKEINKENIHKISEGHCKCNEDICQNCLYLMMKLDLTIVNKLLFEFQRSEFLEKRRLRRKYPQLYKWKRKFEKANFSRYGCVALDPRYIPEIVISTRKEFKQIGKYKVILNYHNAYDDRKLVKTNGTPYNFNIYPVRIPHITFSLFVCDYPKNSYAEFWEMVFSLDISTIFAILSCRGDYVNTTTSYYFPQNKEVFGRVTVSRESEDSFLTEYYVYKYSITKGSVAKDVYIYDVYHWKPYKLPYTEKCIIEIYDIMRNLPTNSRVLIHSEESICTRISSIIFFVNIYEYMTHNKTFDKPMSIITNVREQIPGSYIGIGDYNIIMKSIYESLYLDGYFNDKKCYEKANASFELYRSRRMHNRGKFEDNIVPFLSFACDISVGRVLEILHKACKIRMYNNKETLQKLCKRFYKSQEVEDGQIKNNYPDIPCQDEFTIDFGNFNIEPGNIDGYVHANMIQYKCKNNTQRQIIMTQNPHKNAIDEMLELIYSYNVSIIIHITSYDELTDTNFPSYIPRNVDKKVVHEEFTIVVEDSEIDSETGFKISFCKISTKYQSTKRFVHVLITNWYSKEFMTDEKVVVNAYNTFLRYVEPKRPAIIHCDDGIGRTGVLTLFIHILDFLGESENFNILNHLEFLRKRRLYAVPNGEKIIFTIQCLYEYFKFQLYELNPAVYHRFGDITRNIKHIHQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNM0</accession>
    <name>A0A0N5BNM0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNM0"/>
    <dbReference type="STRING" id="174720.A0A0N5BNM0"/>
    <dbReference type="WBParaSite" id="SPAL_0000749800.1">
        <property type="protein sequence ID" value="SPAL_0000749800.1"/>
        <property type="gene ID" value="SPAL_0000749800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000749800.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34806" checksum="6F4DC73379B9CA09" modified="2015-12-09" version="1">MTISRRIQPYLPTFVLKNFYLRNLFLDEYVSLGFYYYIITLIYSIIVGPFDTLNKLLVNVLFLTIICCLPKESKYLIYSFQGGLLGSIQGNAISLLIFRNISSMNEKLFLIYLNYLIFFHISEFIFTGMSNPRSINGSSFLLDHSIAYWCAILFSWVEFFIEIYYFPYVKIGWISLIGVLFVIFGEIVRKVAIVQAAVNFTHQVASTKLPHHKLVTHGVYSFVRHPAYVGWFFYSIGMQLVLCNPISIIVYTYVIWNFFAERIECEERFLIEFFRDQYRQYQSNVPSGIPFVKGHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNY6</accession>
    <name>A0A0N5BNY6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamine-dependent asparagine synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNY6"/>
    <dbReference type="STRING" id="174720.A0A0N5BNY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000761500.1">
        <property type="protein sequence ID" value="SPAL_0000761500.1"/>
        <property type="gene ID" value="SPAL_0000761500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000263">
        <property type="entry name" value="Asparagine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="12">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="345"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="14">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000761500.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="62923" checksum="E5F3B8C16C3B03BF" modified="2015-12-09" version="1">MCGIWALIGKKYCSEKHGNEFMKIVGRGPDYTTVKQVQSNVWLGFHRLAIVIPGDVPSLQPIVSGNLSVVCNGEIYNHLSIKSSSQINANSVLNGGSDCAAIIHSFLSNNRNIVKTCESLDGVFAFVMADENNFYVGRDALGVRPLFYGNTIDGDIVFGSEVKSIEKIVEKVEYFPPGCCATIPLKRDPITQTYAMELKQFFSVPLIPYKTFDMLEAKTLVREVLVQSVEKRLMGNKKFGFMLSGGLDSSLIAAIASKYLTHQKPVAFSVGFEDSPDLENARKVAEFLDIPHEILVISPQDCIDIIPEVIYALETYDPLIIRCGIAHYLLCKYISANSDVRVLLSGEGADELFGSYAYMQRAPNPAHLHREILRRLKHLHQYDVLRCDRSTSCHGLEIRVPFLDKKFIKLTSKLPPCMKLIKGQLEKYVLRSAFEGWLPEDVLWRSKEGFAEALGKIDLGDIINEHCNKIISDGEYNLRHKLFPHNTPESKEELWYRGLFEKHYSLHKISDVVHTKVYRTAAWHVTDEKENCKDRLMVFCGPSSLRRRSTGSATFSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPY8</accession>
    <name>A0A0N5BPY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPY8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPY8"/>
    <dbReference type="WBParaSite" id="SPAL_0000796400.1">
        <property type="protein sequence ID" value="SPAL_0000796400.1"/>
        <property type="gene ID" value="SPAL_0000796400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="46"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000796400.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23677" checksum="464B6FE02F5FE6E1" modified="2015-12-09" version="1">DPLESSDAESTPTAAAPLNDDNDPINYLPDRCVNQFEVDAITKDFVDDWIVASDAGEANINNHTSKDWAIVATNGTQVIIKGKKVHGNTSTQKLELEAAVKGLEFLRANSKKGLILSDSGFVCSSSQCNYDVTAFPDLWSSFKEKKGETRIVHVSAHSKIVLNEIVDLFGKCYAAGIVEKDMEWPCDLNTAVIRSQEFKELFYKLLKDDAADIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQT5</accession>
    <name>A0A0N5BQT5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQT5"/>
    <dbReference type="STRING" id="174720.A0A0N5BQT5"/>
    <dbReference type="WBParaSite" id="SPAL_0000824700.2">
        <property type="protein sequence ID" value="SPAL_0000824700.2"/>
        <property type="gene ID" value="SPAL_0000824700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894994" evidence="1">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="73"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000824700.2"/>
        </source>
    </evidence>
    <sequence length="269" mass="29887" checksum="9E4CED3A9C3AFFEF" modified="2015-12-09" version="1">MEILRNYTSFFIFVMLVSLIVNLNNAESDFEDLRLIKECKGFVITKAGITQCTPYIVKTTTTKPLAPSTTKADIYLITDVSANVPAKIYASTLTDFLMEFFNNFKIDPKYVNVAFSPSPGDNDTWLTPPVFNEFYGSEVLRNSINSSYYPIMGEQSPGQKQLADVIGMAVNPIFLNTGYNPPYKPHWLIYVTTTSSSDFDAIAAAQKVRKSGKFKVVIIAYHPTGNIEALLRMSDCFYPAYQPRDLSGLATVLAAKIIFDNSIGQDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR51</accession>
    <name>A0A0N5BR51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR51"/>
    <dbReference type="WBParaSite" id="SPAL_0000835500.1">
        <property type="protein sequence ID" value="SPAL_0000835500.1"/>
        <property type="gene ID" value="SPAL_0000835500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000835500.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7928" checksum="957BC3E3E400B2E9" modified="2015-12-09" version="1">MGKVIEIKNSESDYLSMIAQTNMDRRCSQIAPLDKVREVTDSGITGPLKKIKDKGESENKIEYSLYANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR65</accession>
    <name>A0A0N5BR65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR65"/>
    <dbReference type="STRING" id="174720.A0A0N5BR65"/>
    <dbReference type="WBParaSite" id="SPAL_0000836900.1">
        <property type="protein sequence ID" value="SPAL_0000836900.1"/>
        <property type="gene ID" value="SPAL_0000836900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="87"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="578"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000836900.1"/>
        </source>
    </evidence>
    <sequence length="837" mass="96379" checksum="797F89FA2C328EB7" modified="2015-12-09" version="1">MNIQTCGLLEISIDTASKNITINDPFKKEILQLYPKAVVSESNPLGKCTITAPPLMFRDLEMPKLIRYGVPPPLIPEVQKEIDEMISLDVCRLNYNTKYIVPIRVVSKSSKQLRICQDFRELNKKLYTDFYCSPSFKELFMSMKSFSFASRIDLRKAYWQICLHPSDRDKLGFFFNRKVYSLNRPPFGLSSSPGIFQRLMDQILSNVPSLVYQDDILILAGNSRDEHKNYVLQAIQSLHSHGLVINLEKSTFFDAQCIFLGYKVSPIGISPNPKLIQSLKDFHTPKTPYQLRAFRGLFNFLSHNIPDSAKLSIHLNDFIGTLPKSRKEIPIPENVQQDILAMKDSMSRIVTLGFPDFSKDFLLMCDASNTGYGSILMQSHAPINTYLNPKQLYPIAVHSRSWDALARSATPTYYELKSISRSLTFFSPLIRYSRIHVFTDHKNLLRIIMDGSLPIYQKYIFNICNFNCVIKFIEGHNNPVADALSRSPLDGSQDTVNCISKNEEIDIDDLYQSFHVNTGHLSLIKVKESLMQAITKNHPKLRVARRILKQVASKISQCQACRSNNVIPRKKDSDDEYKVTKPMELLCLDLSKYQNTNILCVVDRYSKYKFFFELKSTTGDQIVKIIKSKIVDVYGLPQRLRSDNARNLIEGPVAQYCKEQFILQESAIRYRHTTNQIVERAFRTLFEMMRKMPKVRGPFSENLKIASFRINNIKNDKGISPAELFLNFMPRTLQDNKYNIQSQYNVQDMRALYELLHSLEKLPKEIVIKDFDLKKTKAENRNITLKNEFKPINRTAVKTSGGKYVNKFEVLSRSKKWATGDTHKDKDSKDLSSNESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRF0</accession>
    <name>A0A0N5BRF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parkin co-regulated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRF0"/>
    <dbReference type="STRING" id="174720.A0A0N5BRF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000844900.1">
        <property type="protein sequence ID" value="SPAL_0000844900.1"/>
        <property type="gene ID" value="SPAL_0000844900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000844900.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32464" checksum="3420DEF796BEEB72" modified="2015-12-09" version="1">MARRSKSLHIFEEREQKNNRENNNINFVKDNKRLQITYEKQKSFIKLVPPFSIQSTQKNTEVFTLPCKYAKSSKIKNMDDVTKKMINRFKTAYLDRQIPLQLVDGIKKKTILWNIPLKEMDIMTINKLIRIVTLGLPCSESPYETIALEAFDSLLCLPGTEYVIFQVLTEIVTAIRKALDYGNDEKKIKILGIIIKMTKIKHIGISLVPYYKQLLSPLRQPYSKISFSNEKANKKNDSNYHLSQYIHKTLVALEESGGKNALVNICYVIPHYQSIYYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRI6</accession>
    <name>A0A0N5BRI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hcy-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BRI6"/>
    <dbReference type="WBParaSite" id="SPAL_0000848500.1">
        <property type="protein sequence ID" value="SPAL_0000848500.1"/>
        <property type="gene ID" value="SPAL_0000848500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000848500.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44701" checksum="68437DC8AE955E9A" modified="2015-12-09" version="1">XFSPLVDMSYRILDGGLGTTIQKMYSNNRQGNQTYIDHGFFSFNLTIDKKLLELANVHMEFLKNYSETLYTSHYQASIPKLYKKLRNLNEIWHLLKISYEIPKCIMKFYGNDARNLSSFPSVFVSCGPMATYFQNKYEYCDLKCHPLYKNGIYENEIVDMYYKIQVQSLISLSPECIMFETFSLYDEIKSLINVLNDLPSNVYSNICFGLSITCKDEKVTFGGCNIVEIFTLVSESRKFKYFGINCTYPKCISKVLQSLSTFNCANNNLEIIIKSNKGDIMYENGLPHVVEGAKMFFEYVDEWSKILPIAGIGGCCGVLPEDIGKLHRKKHNINLIIENQSMVKEEDLKFLIEKVIGDSEESCSNKHPGIEVKDLEKFYELVKNHKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSZ7</accession>
    <name>A0A0N5BSZ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSZ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BSZ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000899100.1">
        <property type="protein sequence ID" value="SPAL_0000899100.1"/>
        <property type="gene ID" value="SPAL_0000899100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="443"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="750"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000899100.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122681" checksum="2F22B8AE5BA876E5" modified="2015-12-09" version="1">MGNKKVIIPCGEKGSKGGYQDKSQQKPSSSNPGSILSKLIEAAKQGQPSSLKGSVKEQKQITQTSKTIPYESSEVSKQVQLALSGTSSKKQKKAQQTARSGKNKSTEVSKQGEGQSSTISDETKKITPQSTKSISGKSSIISEYITAPSSKASDKEQKSTPEITENSSYKSIVISGQSEASSSKSPAKAQETTSSITTEEDKSIVGYKGSPQKLSTIELSDYKFYRQRDQDKDKLTVGKDLSILTNVYQFKFSDNLYVDLYSIHFLNSEKKIDNKFKHSLKRDVVMKILYREIENKSDLNNFVYDDHNLLYVKSGVLEKEEYEYCVDPEARKVMYVRFEKAKHLPIVLSNTDNTTFCESKKFLSLMITQFSKFSFSQNYNKRYTGIRNKLYFRPPTAASDRLSLDFMRQIWSNLCFNILLGPQGLPLINVHQGYGLFAKSELTVIDFYCCINGTKRRNIDMNSVSMNEDQRKNLTKLLKGLNLTLEYDKSREFTIFNVVDKIPEKTFFYRSGVKISILEYFDQRYNITLKYPNLPLVQMNPEKANIFIPMELVKLSDKPQRLHQKLDIELTAKISKKRRKYPAVLFKEINTNLDAVKRDANDILRAFGANIGNQIKTVAKALPNIGMKYPADVRKRESYDKHLKNFSYGVVIVDRSVYCNKHNEYIDKIKHIIKTVTNYGCDFSKNLDPRYEIDYDSRCNLFDFLNPRLGHIDKNHRKNHLMFFIIRDNTTSYGMIKMYCEHKDFLGCHSQVLRTTTFNKINLEDPRCMITMNIAMKLNGKLGGLSKQLYYKQSNPILNDFCKKFFNEKDATIYIGADVIHPAPHDTGDYPLPSISAVVGSVDILGSKYAVSGGIHTKTVQKGKQVTETLQYFKDQVKERLISFKNSTGVVPRHIVVFRAGISKSQFKITMDYEVSSIHEACKEINEKYKPTITLLITQKHHGVRFMNPQNNPNYNVPHNTVVANGIVNPEILEFYAVLHKGPIGTARPCQVYTLYDEWNLTLNEISLLTCWMSNVCTRCPGPIGIPTPCYYADLACTRFKHHYIGRKEYLKKTQENTGVTIDIHPLLEEEQFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT88</accession>
    <name>A0A0N5BT88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT88"/>
    <dbReference type="STRING" id="174720.A0A0N5BT88"/>
    <dbReference type="WBParaSite" id="SPAL_0000907600.1">
        <property type="protein sequence ID" value="SPAL_0000907600.1"/>
        <property type="gene ID" value="SPAL_0000907600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000907600.1"/>
        </source>
    </evidence>
    <sequence length="835" mass="95039" checksum="E604EB7BD5682443" modified="2015-12-09" version="1">MSSNINDSICDFFGGEPLDGSDNSHRRCPYCGRDFADYKMIRKYRHIEACESLLKRQNNTAKSGNMVVGKTKQCMQTTLDSMIQSTCSSGGSKKSLTQDIFLSGKPSTSFLTKSKSVTTRNVKNSKICSCPYEKDHIKDRIAGLFSICEKDGKENVNFSREPFISSKRLLHYEILARDFQRLTKRCQGDVTVKAKNGDLKWHKMILQIRTKFPLNDVIDLSEFTKESLLAYEKYIYGGEIRYSYHLLKDLKTLAERYGPDSLKYYLENDFIIDENAEYIEKYEVRKRNNALDLSDKYSGETNVRFITTNQQVPDDSFDQTMDYGVFKNKESQSQGEPSTSTDGDSKYESFPSDNATEDSNISGEIVNETIQVEDNEDTELPGGKINETIQVENNEDAELPSEEIYGTIQVKNNENTELPSEEIYEAFQNAGEEDINLSHESDILEKNLVINSQSSDKSYKDAYPTGNDASYLDYEDSNAGIIVFDAEDYMTNDEMSKSQTENLSQQHNDAPDYNVSSPLQQSFADDSFCGIIEGGYYSNESRCETPVHNAEKPNVIKNNPPIPEGGKDQSNDSTAQKIPSPIFKTPTVSKATNQNNSDRNGVTKSKREMIEQQLTKSSQLIKYTDITPRPMYEQMSDLELQQELAKYGMGKRSRKKAILDLNKIYNQLHPTVFVDDVIESPKGRKRKSKNDVEISSFDNHDDHSSITVEGNETNCSIDSSSSQEVNILEESCTEFLNSQEVDVPTNTKEKKPKTESEWKDVFVEFIRLPQNKLTYNRMLSYSTFELSEIYQLVKSSTHLIRFISKPMLVTVLDELHISFTIPSEGWENKAKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTD9</accession>
    <name>A0A0N5BTD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phenylalanine-4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTD9"/>
    <dbReference type="STRING" id="174720.A0A0N5BTD9"/>
    <dbReference type="WBParaSite" id="SPAL_0000912300.1">
        <property type="protein sequence ID" value="SPAL_0000912300.1"/>
        <property type="gene ID" value="SPAL_0000912300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="10">
        <location>
            <begin position="158"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000912300.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="57754" checksum="907A0AA10076ACC3" modified="2015-12-09" version="1">MDLPEQSVPKRRTSLAKLDTLVRQASQERIKNEGLQRSNTIKSRKFFEKTQNKNFYEKLTDDSVLCINASPSSGEFKLAVIFTPSISTNTFLTTIVSQFSSHGINITHLETRPIFRLPDSNSDGKNLIEILIECSVTKTKLLLAVSAILENEEIDKIQLKRLIENPLVAVPWFPKHISELDKCMHVVTKYEPTEDPRHPGYGDIEYIKRRGELNNIANNYKWGDKLPYIEYTEEENNTWRLCYAHLKKFRQSHTCKEYRENIKAMEDAGVISENAIPQLCDLNNFLFKKTGFQLRPCGGLLSARDFLASLAFRVFQTTQYIRHSSSVHHSPEPDAIHEYLGHVPMFSDPWVAKMSQEIGLLSLGASDEEIEKLATIYWFIIEFGLCYEDGKYKAIGAGLISAFGELQHACSDTPRHEDFDPEVVGKTSYDDSDYQVVYFVANNLKIAFQKIKEYAKAFRKPFTLTYNPYTQSIDVLSERENIENKIKELKNYLNELSFYLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUF3</accession>
    <name>A0A0N5BUF3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BUF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000947400.1">
        <property type="protein sequence ID" value="SPAL_0000947400.1"/>
        <property type="gene ID" value="SPAL_0000947400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="63"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000947400.1"/>
        </source>
    </evidence>
    <sequence length="1244" mass="144132" checksum="BCDFD115F93CA77C" modified="2015-12-09" version="1">MATDELGPVGDDSLFELCDCLLHCNSSFLKQRNLKGYIPYASVYDSLEDVRKRGYFIPGKPVVAKIIDVSRDEQSHVHVINAYLYTIQLTHGKYSWTVTKRFSDFLNLHRRLMAHRAVEKVKQPIFSKSSKFEDVLKVVAANNYHRYDCPLYQLFNEQTNNIQTLNYTGDNISTGQTKKKRDIEGNVKEPQLATPENMDSPEIAKVLISTNFSLPKMPKVPEIALSEESVEERRVQLEKWIQAVLATPINRNYHETAEFLEVSRYSFINQIGKYKEGEMRKRPGGARVFLGWKQTCVRYFLRWSHRWLILKDSYVCYMHPSSSKIRLVLLIDNSFSINCPNLEIAYKPKDLVISNKQHILHMKCGSVDEVEFWKSEIRKIMENSGKIWLERHPHQSSFPLRNECYSKWFVDAKEYWEYAADMIELAQEEIFIADWWLCPHIYMKRPMNEGNKWRLDVLLKRKAEQGVKIFILVYKEMEMALNLNSLWMKKTLQDMHPNIMVMRHPDHYPATGTFFWAHHEKLLVIDQIIAFVGGLDLCYGRWDDNVHRLTDLGSIQMPTYGVVNNSCDYNLISGMRQVAGMSASLCPSGKIFEEVQNNDSVDLDVKTIESDDGVKCDDDTKRIVKSKLVQKKSSKMASIVTKLRPSKKNKEHFLSNKPQINSHVDVKMNDASGKQELSVAVKDQGKYKVEIEYEDKNRNSKSHSRSRSKSPLEHDDHFEYPEDDGREDDDHKLPTGDKKVWGKVTRNIKDQTRSKVGKIVSHWGTNRMKNRWKDVLNDDSALGQYELNWLKLKSSNEENNGKLQGGGKLWPGKDYVNYNKKDFIEVNEPFKDFVDRRKVPRMPWHDIHSVTFGNAARDIARHFIQRWNATKTEKLKDEKKYPYILPKSYDSVRIPRIFFPISIPTSVQVLRSAATWSALVSETEESIQNAYIELISTAKHYIYIENQFFVSMVNSTDVLNKICKALVDRITLAHENKETFRVYILIPLLPGFEGELSSNASPTSLHTVLHWTMVSIDNSEMSLYHCLRNRAINPDDYISFCSLRTHSVLWGKMVSELVYIHCKCMIVDDEKVIIGSANINDRSQVGNRDSEVCLLIIDNEYNYGMMNGKKYKAGKFAQSLRYQLMKEHLGLLEDSPSKTSLSINLDDPISDQFWDQWNGIAKSNTEIYEKVFRCFPTDKAETIEELDKWNMQLPLAELDPKEASEILKRLSGNLVIFPRKFLRRQNLQPAITSKEGLVPSSVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUS8</accession>
    <name>A0A0N5BUS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000959700.1">
        <property type="protein sequence ID" value="SPAL_0000959700.1"/>
        <property type="gene ID" value="SPAL_0000959700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000959700.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17606" checksum="7D13E2836C844C88" modified="2015-12-09" version="1">MPSLRDEAKYYCPYCKETNYIEDQEFDVIQLKTHLEAFHGYSSKTSEKSYCQECLRTRALGDLRVNPKRIAPFWMIRHIQNKGCYKVPGRDNQQVNIQQEEQEEMLDTSVENTDMEVISQSILEENEEAEDNIFDDLIDLENIHNDPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX76</accession>
    <name>A0A0N5BX76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX76"/>
    <dbReference type="WBParaSite" id="SPAL_0001041100.1">
        <property type="protein sequence ID" value="SPAL_0001041100.1"/>
        <property type="gene ID" value="SPAL_0001041100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001041100.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29706" checksum="3027780074921A9D" modified="2015-12-09" version="1">MNSPRNSYASLANLNQKLRVLQNQCKNEGRNVKETLCRDAEMIIQEACNNIGKLLEQKNNAIIEKDHDNIKRIDEEISIIESTAINMANLDVLLREKYTDDVVKPFIEPEASNIKVKITEEEIQKIRKIEREKIKKENDRIKEKEKLREARKDEYINELGFQDIKKNISFKETPTYKSFHKSLQSKKKNNSTPSDDESGDEYETKNSESSLRKGPSEEEVRIAMKKVKEEKNEELNHELDKYYAEIEKIIEGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXR1</accession>
    <name>A0A0N5BXR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001058200.1">
        <property type="protein sequence ID" value="SPAL_0001058200.1"/>
        <property type="gene ID" value="SPAL_0001058200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="207"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001058200.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54478" checksum="DC63E41628664B4D" modified="2015-12-09" version="1">MCDNAGTFNPLSPFIKIRKGPKHCEFDLRKLKKCADGFVVWNDKISNLLTNSYPHHNIQKKIIRKVKKTKYWCSIPTKKHPYAGDGEICIHKVVILEHNFYREQNGENDNESGIFVNEVDFKNKCLSTDNLIVSGSPSSGTVSMSMDNVLGDNKTVSEVPSEKLSIDEKTTLGDSPASIAPDKEYKNEDNVTVLKKTSDDCFVDKPRNVHLVIFVHGLEGTPHDLAEYPHFITQVNPNVLYKFYNSQSNFEKTWTDINTLGENLLTEINLHIQLLDCKPNKISFIAHSMGGIIVRSMFNVEGIEKLKPYFHTLLTINSPHCGINYGSKRVTIGVRFLEWWFNSNSIKQLSFKDTNTLDESFLFKLSLNDAFSSFKNVLLVGNYQDNFVCGSSALIEHNTKSYYDKSRIGRLYDKMIENIEQLIVNSNNETVLIKYIVTHNSDGGLNFDRLIGRDGHVHPCDDLHFIEKIMHCSAGKYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXS9</accession>
    <name>A0A0N5BXS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXS9"/>
    <dbReference type="STRING" id="174720.A0A0N5BXS9"/>
    <dbReference type="WBParaSite" id="SPAL_0001059800.1">
        <property type="protein sequence ID" value="SPAL_0001059800.1"/>
        <property type="gene ID" value="SPAL_0001059800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="302"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001059800.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="86738" checksum="1A2BD9FC047962AD" modified="2015-12-09" version="1">MSSEIKDKSKKRKKISIESDDDDILESPIIQKSKKKIPKLTKIESEDGEIDEGDLDAIRKSFKNSKEKKSPKNKKQKNNDAGQTKLEFFISKDKSVENKEKNKQNSGLKSISVTDYFSRSKDTKNTTTLNDTIEITDDDVLADSQKEVENIEDKKKPSQMKDSPRKRSSKNELSGEDVPVVKKATRESKSKLADTNVNVTKSNETNKPITQKNKVSPKKTIKEEVIKPPKSISNKKLPKDQLWVDKYTPKTLKELVNQQTDKSQANKLLNWLKEWYKNNLGENKNVKKVKPTGMAAKSDGVAFKAALLSGPPGVGKTTCATLVCKELGLNYVQLNASDSRGKKVLQEKIEEFLQTKTINSFFKSSKSKDKSSSKLEQVLIMDEVDGMSGSDDRAGISELILMIKNTKIPIICICNDRFNRKISSLANHCFDLRFAKPTVNQVRARLMTIASNEGMKIPLEKMSNVVEASNLDIRQSIYNLQLMKFSGDTKDLNSKDTDINIFDAARQILDPRTSLLDRRRLYFTDYSIMPLFIQQNYVNIEPVKLNKKETLKALSKSASVLSDVDVFERQIRTNQDWALLSDQCTFAGYLVPSYMQGYLSDQISFPTHLGKLSTTNKRYRMASQLAFHMSTKLTVDTTTLVTEILPLLRKQLAEPLINKGVDGIQEVIDLYNQYSLTKEDHEFITELTDWSNSEEIEKSIPSKVKAAFTRALNKEDRKLPYADLENDVIKVGRNKKNSKKEVIKDEDSQDGSSEDESQIVPEFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYA6</accession>
    <name>A0A0N5BYA6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYA6"/>
    <dbReference type="STRING" id="174720.A0A0N5BYA6"/>
    <dbReference type="WBParaSite" id="SPAL_0001076700.1">
        <property type="protein sequence ID" value="SPAL_0001076700.1"/>
        <property type="gene ID" value="SPAL_0001076700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="entry name" value="Glycerate kinase, MOFRL-like N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="entry name" value="MOFRL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82544">
        <property type="entry name" value="GckA/TtuD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOFRL-associated" evidence="3">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="2">
        <location>
            <begin position="311"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001076700.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50659" checksum="773E26EC8BBFCA87" modified="2015-12-09" version="1">MIAFGKAAFPMIIGAESELGKYVLSSIASIPYDVNIPKVANLKTIFFKGGKNNLPDKGSLEATNQINNFINNIPKDDVVLILISGGGSALLPAPIPGVTLEEKSSITKLVAAHSADIRQLNIIRQSLSTMKGGQLAEKLYPRKVISLILSDIVGDPIQYIASGPTYISESIEGESRRIRRYKEAIGVLKELNLFSNISPHILEAMKIYAYDKDNMEDKTLLNDGRVRNYIIGNNMKGLQILRDNLMSLPCDYCLDDVAIVTDSLEGDVEVLAKNYCIVIKKFLEYGKIDLSSINSTIKPYKIKSNQTKIGFLFGGEWVIKLNKNNKNGIGGRNQHLVLEILSNLINQIHDSSVLEKRNFKLLSFNTDGFDGPTLAAGAMIDGKDLIYFLSQNSNDNYKEIVNDDFTILNITTHLANRNSFKFWEKYKNSRNHIVTGRTNTNFMDITILILEILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYE2</accession>
    <name>A0A0N5BYE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYE2"/>
    <dbReference type="WBParaSite" id="SPAL_0001080166.1">
        <property type="protein sequence ID" value="SPAL_0001080166.1"/>
        <property type="gene ID" value="SPAL_0001080166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001080166.1"/>
        </source>
    </evidence>
    <sequence length="61" mass="7368" checksum="036F7D113138ADBD" modified="2015-12-09" version="1">MTGGGVFAFCQDQRVPDYVNFTRNTYFLMDWRIKSSYVHLHKLFKTFYSNLSFFTQTKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZC3</accession>
    <name>A0A0N5BZC3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZC3"/>
    <dbReference type="WBParaSite" id="SPAL_0001111600.1">
        <property type="protein sequence ID" value="SPAL_0001111600.1"/>
        <property type="gene ID" value="SPAL_0001111600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001111600.1"/>
        </source>
    </evidence>
    <sequence length="53" mass="5821" checksum="975415A39C96F35E" modified="2016-05-11" version="2">MSLRSSSTPVKANNRLGNDSNDLVPGLPLFNAFKQAELGLSKDARHPFLDHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C057</accession>
    <name>A0A0N5C057_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C057"/>
    <dbReference type="WBParaSite" id="SPAL_0001138800.1">
        <property type="protein sequence ID" value="SPAL_0001138800.1"/>
        <property type="gene ID" value="SPAL_0001138800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001138800.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36515" checksum="A8021EB99688151F" modified="2015-12-09" version="1">MFGDKLNVSVIPTSIEKEMYDNNNLENEGLKDKKKEDSKNLDGNALLRKKRAEATQRYKEALKNPTDPENAKIIAKREQMRLASKLRTARYRERQYFLKHGQHTNSKNDMNDQLEEKKKALEQVEREIRKTKYRLEQLENVKSQILHSIINNTKLRTSFTKSIVPDEGLQEQDKSSSEREENIKTLESLLLTDEYNESMSTTSVSPLPETSVDSDRLKAFGRLSSLWSNVATIINEALEKSNVTPKTTQKEPVQSSQSQSTEISPLQSKRRKGNVNIDEITDSYERKKALARLRQQRYRARKAAEALKGELKKNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0W9</accession>
    <name>A0A0N5C0W9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0W9"/>
    <dbReference type="STRING" id="174720.A0A0N5C0W9"/>
    <dbReference type="ESTHER" id="strea-a0a0n5b3w9">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001164800.1">
        <property type="protein sequence ID" value="SPAL_0001164800.1"/>
        <property type="gene ID" value="SPAL_0001164800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895168" evidence="5">
        <location>
            <begin position="22"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="35"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001164800.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64677" checksum="C722917967567DCC" modified="2015-12-09" version="1">MLFNINILIFISFPLFYSVISGPNNCKPAGIYNIENNTVTEYLGIPYAKPPIKELRFMPPEGIGEFKTNETFNATIPARTCPQFIPPNIFPYNFSGFSIWYPPKNISEDCLQLNIWQPNKTTGGVLVMIHGGAYYSLSASLDLFNGSVLAAVAHAVVVTINYRIGALGFARWKDGKNITGNMGLLDQQMALKWINKNIHLFGGNNKSITLIGEHAGSSSAVAHLFAKNSSDLFSGIITASGTLENIWATQRNEYIENATMLLAQNLSCTDTEEEKVLKCLQNISNPMAFINSTLMLRGKMAPPFGFPFAITHNDGNFFERNISDMSVENDMKKNFSIMLGDTGNEGSFFLYNYFRTYGCTINFTNVEDPSHQCLINNTVFENITHIITKMLGKDEEWQNEINEVYDHIHKDKFRNILSKIMSDLLFDCGLKRFAEQIVNTTSNKVYYYIYNYTSSLNPWPRWMGAVHASSMETVFGYPYRYPNIYNKTFNETDKNISYNIMKIYGNFASGTFPYSELYEYNKTSKNVGVLDQTLTGPFPKYYINDSYTQKCDLFSPYIIKPEINTTTPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1D1</accession>
    <name>A0A0N5C1D1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1D1"/>
    <dbReference type="WBParaSite" id="SPAL_0001180600.1">
        <property type="protein sequence ID" value="SPAL_0001180600.1"/>
        <property type="gene ID" value="SPAL_0001180600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001180600.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25091" checksum="9A6F046A63FD38FC" modified="2015-12-09" version="1">MDTIMDDLFLKLENLIERKEESRRQIWEMTKAIPGFSGRINVNYPKFSSFKTKNERTDLIAQSLTKLLNIEKPIERFGKKNLSRKKINFERKNAPAKEVQVNYAKAVVEGEVKANYEEAVVEREAEVNDEKAVVEVGAEVNYKEAEVNDEKAVVEVGAEVNYQEAEVNDEKAVVEVKADVNDEKAGLEKEFSTNLKITSEKKFDWNDIIEKEKLKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1G4</accession>
    <name>A0A0N5C1G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1G4"/>
    <dbReference type="STRING" id="174720.A0A0N5C1G4"/>
    <dbReference type="WBParaSite" id="SPAL_0001183900.1">
        <property type="protein sequence ID" value="SPAL_0001183900.1"/>
        <property type="gene ID" value="SPAL_0001183900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001183900.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="32817" checksum="EB0D204F114AAE03" modified="2015-12-09" version="1">MLSNIMLDKQKQVESLRKFAFCGVTMSTVAAIICLFSIPMIYNYMQHVQTMLENEVNFCKSKTGSLWKQILHVYINKEDSIRGKRSPNRRAFYPEVPVTNNNPYFPPTGAVRLETQVAEQCCGCGFGPPGKPGLDGQDGIDGVDGNPGQDGKPGKDDNQDNNDNREGEWCFDCPEAPMGPPGETGDKGEPGPPGDAGDEGESGFIGPPGPVGPPGLPGLPGEAGLPGPVGKPGDLIQMDSRPGPPGPPGRKGPKGPPGNPGVPGRPGEPGAPGPKGDSGSPGPDGKPGRTGIAGEPGVPGERGTCNHCSPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Y7</accession>
    <name>A0A0N5C1Y7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Y7"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0001200500.1">
        <property type="protein sequence ID" value="SPAL_0001200500.1"/>
        <property type="gene ID" value="SPAL_0001200500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001200500.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20173" checksum="CAAB8418771968F4" modified="2015-12-09" version="1">MDLLSNDMAGMFQSTMFSDCAIEVQNSQIKVHKCILASRSEVFKSLLTDDGCKFSPNGIEMNGFRLEVVNEMVNYLYTGKSPNMDEMALELFEIGHKYELEQLKSMAEESLLYSLSIENVLDYLECSLLYSSKVLEEFCLRFIHLNAENLINTVKWRAVVNNNPLLIAKLYSIGITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C208</accession>
    <name>A0A0N5C208_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C208"/>
    <dbReference type="WBParaSite" id="SPAL_0001202668.1">
        <property type="protein sequence ID" value="SPAL_0001202668.1"/>
        <property type="gene ID" value="SPAL_0001202668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001202668.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14528" checksum="1F4FBEF41C61BED4" modified="2015-12-09" version="1">MGIRRQILMKKANPVINTKCSRKKYNLYLKLKVANPTPLLSGITTSQQNLIIFANGQSPKQEKDISRTFFSNQALSPSISTPSIYIPSSNIPNSTLLPIIDSNGNNNVGPGTKDSHGPNVQVKKHGRPRTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C225</accession>
    <name>A0A0N5C225_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C225"/>
    <dbReference type="WBParaSite" id="SPAL_0001203900.1">
        <property type="protein sequence ID" value="SPAL_0001203900.1"/>
        <property type="gene ID" value="SPAL_0001203900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001203900.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60814" checksum="B99AA5577A1DF845" modified="2015-12-09" version="1">MIFFQLFIFSLLHLFSYGYKILLFNPKFGHSHINFMSQMTKLLSDAGHEVIVLSSIIDDRLKDPYYEPGRIYYTKPHPAFVEFAKNPSTLKAYWNSKEGISDQTELFQRLVDSIRQQGISILNDDELKKFIMEQKFDIAISETFYHFMFGVFKYWGIEATIATTSMFMIDFYYPMFGIPFAPSFIPSFISGYTDKMSYKERAINLLFHAYMWHYAETHSKHNNLQDVFDKKFGVGFYDEYKVLTNVSFFFINTNPFLGIPTPISPKMIEIAGIGVPKPKPVSEEFNEILNMRNKTILISFGSVAKSTYMDQEMKDEILKTVQSFPDITFIWKYETPEDGLGKGIENLVLRKWVPQNDLLNDERLSLFITHGGMGSTTEVAFSYVPALAVPIFGDQMRNAKLLERLEIGLAVEKDTLRNSKKFREKILEILNNDKYKINSIKTAEMLRNRPISSEELLVKHVEFACRFGQLPRLDLASKDMGVIEYYNLDIIVPFFIVCFIIIYGIIKVFTKIIAKLFLNKIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C452</accession>
    <name>A0A0N5C452_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C452"/>
    <dbReference type="STRING" id="174720.A0A0N5C452"/>
    <dbReference type="WBParaSite" id="SPAL_0001273700.1">
        <property type="protein sequence ID" value="SPAL_0001273700.1"/>
        <property type="gene ID" value="SPAL_0001273700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF45">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895428" evidence="5">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001273700.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43227" checksum="73955AFB082804A7" modified="2015-12-09" version="1">MKSFIIFFTLFSIVLSDTVEISIFSVESIKQKLIKSGEWGKYYREKQNSLRKSHLNSSSSITQLVNDYDDAEYVGNITIGTPGQLFTVVLDTGSANVWVIDKSCNNGSTKEACSQKRKFDSVRSSTYTIDDRPFRINYGIGWVRGFFGKDTLSLLGNGKNLKIDQTTFGQANAISEDNGKSPIDGILGLAFKSIAFGGVTPPLIEASESKILPKPMFTVYLQKKGKVSGAVGGSFTYGGYDVKNCGPVLAYQKLTSASYWQFKLSSIGYKDKVFRDGWDAIADTGTSVIGGKYVMDALAGKLGGIWNKNFEVYTIPCNTISEIIKIKIGNNVYDVPTSDLENVIKKDLCMINLLPIDGVGSGTQFILGAPFHFSYCVTYDVGNKRLAFSYHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C536</accession>
    <name>A0A0N5C536_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C536"/>
    <dbReference type="STRING" id="174720.A0A0N5C536"/>
    <dbReference type="WBParaSite" id="SPAL_0001306500.1">
        <property type="protein sequence ID" value="SPAL_0001306500.1"/>
        <property type="gene ID" value="SPAL_0001306500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF4">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001306500.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="46907" checksum="B4964FEB71F3E246" modified="2015-12-09" version="1">MILYSKLSIFFKLIIFILIYLAYYGSAFDVPCTQKLIGQQCLFDEECYGINSFCRDGRCSCPTNFEEYDVNEQTRVCRVAPSKIGDSCQRDCKPPLLCRDGKCECWGGSIVNGKCVVACPTGYQLYGVECTRVAHWNQQCEKDSHCVDPFNACLGGLCQCAPGTVRDNLRKKCVAVCPDGQKPKQSCRRLFINDIDMLENAASTDSCPSGYRCSTYGSPYIGHCCKLKCPYGEPDLTQSCDNGVPENEKCRSLTHFCYTISEPGWKSSLCCPRPCRNPTPLYLNGRCVSLAHREDACQIDQQCEGGMTMQCILGVCDCKIGFKPNNDDRFPTCEKICNLEEVAVGDRCLTRSSLGERCISDKQCPNFSECRFGVCQCSCGYRQTESLLGQRCSNPEDPLSLNTILSGVEELFGNRGRDNGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5E2</accession>
    <name>A0A0N5C5E2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5E2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5E2"/>
    <dbReference type="WBParaSite" id="SPAL_0001317100.1">
        <property type="protein sequence ID" value="SPAL_0001317100.1"/>
        <property type="gene ID" value="SPAL_0001317100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF126">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001317100.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12747" checksum="088157BF50E4970D" modified="2015-12-09" version="1">MQIFGMKQQAVGVKGRLLCGSKPASGVKIKLWDEDEGVTDMNGNFFLQGSTRELTSIDPVFKIYHDCDDGIIPGKRKVKLRIPSQYIFAGSTPKQPMDLGVLNLETIFAGEERDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5V4</accession>
    <name>A0A0N5C5V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5V4"/>
    <dbReference type="STRING" id="174720.A0A0N5C5V4"/>
    <dbReference type="WBParaSite" id="SPAL_0001333000.1">
        <property type="protein sequence ID" value="SPAL_0001333000.1"/>
        <property type="gene ID" value="SPAL_0001333000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333000.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="40528" checksum="59F741B215348F34" modified="2015-12-09" version="1">MIVILLLTITILYLINFYRKVKSFPPGPTPYPIVGNLFSIDFKKIHQWLYDQKKNYGSVYTIWAPVPLVVFTDYDSINEALVENDDHFVGRNTYGLPEKTFYDRPNVGVIFSEGEEWRDQRRLSVHILRDFGMSRTIIQDKIYLVIQDLYDYINSLENKDNVNIDKILQLSVGNVINQILFGIMYSNTENNEFFEFAEAFEEFVKGTRGWEFRILFLFPIIDKIPIINNYLYKRITRKQRKMREISKIQVEKCKKTYNPDDEPPNFIHAFMKETQPTNSKYNYLDSYHLDAMVLDFWLAGFETTYITLRWFIAIILKHVDVQEKLQDEIDRVIGKDRLVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6S3</accession>
    <name>A0A0N5C6S3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6S3"/>
    <dbReference type="WBParaSite" id="SPAL_0001363800.1">
        <property type="protein sequence ID" value="SPAL_0001363800.1"/>
        <property type="gene ID" value="SPAL_0001363800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001363800.1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4827" checksum="5CEA5F83080D8662" modified="2015-12-09" version="1">IFSLTRVHVNPPKIFVKKRNLEDCVIFGKKCNLGFYIIVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7D5</accession>
    <name>A0A0N5C7D5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7D5"/>
    <dbReference type="STRING" id="174720.A0A0N5C7D5"/>
    <dbReference type="WBParaSite" id="SPAL_0001384900.1">
        <property type="protein sequence ID" value="SPAL_0001384900.1"/>
        <property type="gene ID" value="SPAL_0001384900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="212"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001384900.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55841" checksum="67021B3215581AC9" modified="2015-12-09" version="1">MNNLYEQFKAIKLKDPKFFNSLIDEAKDFSVVHGNVLRLNSSKDRSDVVKHSPITLIPSPFPKKLYEQAIEIQPLMNKLYFKISLDNQFLKESIECVLEIDDFTRKLMNIYDIITAEGIKQPITLLLQRADYFCHTTNHNNQQVYELKQIEVNNIAAGMSSLSQITTQMHRHILRNSSISYCEDKIPQNRGNDTVGQGLAEAWKMYGNTNAYVLHLIEDVNQNQLDHRHIQYSTDYFSSYQCKTIRIPLSECRSRLKLGKNYELIMDDKYEIGVVYFRTGYSPNNYIDDEDWDSRLLIERSRAIKSPWIGLQLANMKKIQQVLFEKGVIERFLDNSEEIQKVTKTFARMWSLNGNIDEIKKDVFENNRNYVLKEQLEGGFGNYFDNDIIEKMKDGDVLKSCILMERLNPLKSRNYILVSGKEPEDCEIVSELGIMGSYIGNIKTKEEYFNHYGGYLLRTKKSTETKGGVTIGASSIDSVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7H1</accession>
    <name>A0A0N5C7H1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7H1"/>
    <dbReference type="STRING" id="174720.A0A0N5C7H1"/>
    <dbReference type="WBParaSite" id="SPAL_0001388400.1">
        <property type="protein sequence ID" value="SPAL_0001388400.1"/>
        <property type="gene ID" value="SPAL_0001388400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF110">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001388400.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="54352" checksum="1E8F0910990B156C" modified="2015-12-09" version="1">MGWLQKNLLLTLTIGSVVLGGILGFILRSTNPSPQTIMLISFPGEILMHMLKMMILPLIVSSLISGLAQLDAKESGRMGSYAILYYVVTTVLAVITGIILVLTIHPGDPTIKQEISAGSEARTVSTVDTFLDLIRNMFPENIVQATFQQTQTKYVKTRPKYVKSNDSETLKALANGTFDYMKPSVEYTSGMNVLGVIVFCIGFGIVVSRLGEEGRIMVQFFSTLDKVIMQLVLYIMWFSPIGITCLIMGKILEISDLAETAKMLFMYMLTVLTGLAIHSLITLPALFFFLTKKNPYVFMRGLLVAWITALGTASSSATLPLTFRCLEENLGVDPRVSRFVLPVGATINMDGTALYEAVAAIFIAQMNGVHLSLGQVVTVSLTSTLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVDHFTKEQFRLSDEAHARQLAEETGVLLDSGSPTKRANMTTNWSASHGAYTSLSQNDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7H6</accession>
    <name>A0A0N5C7H6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoyl-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7H6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7H6"/>
    <dbReference type="WBParaSite" id="SPAL_0001388900.1">
        <property type="protein sequence ID" value="SPAL_0001388900.1"/>
        <property type="gene ID" value="SPAL_0001388900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050709">
        <property type="entry name" value="Biotin_Carboxyl_Carrier/Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45266">
        <property type="entry name" value="OXALOACETATE DECARBOXYLASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45266:SF3">
        <property type="entry name" value="OXALOACETATE DECARBOXYLASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001388900.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9125" checksum="E79F09E9943DF0C1" modified="2015-12-09" version="1">MTFTSEVPANENKKTVIMSPNTGIIENIKVKVGDVVNEGQELIVIQSMKMQSKLLAIKNGRIKNVNCKVGDNINIGEVLIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8F7</accession>
    <name>A0A0N5C8F7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8F7"/>
    <dbReference type="STRING" id="174720.A0A0N5C8F7"/>
    <dbReference type="WBParaSite" id="SPAL_0001420500.1">
        <property type="protein sequence ID" value="SPAL_0001420500.1"/>
        <property type="gene ID" value="SPAL_0001420500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001420500.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58129" checksum="D3DD89FD96337DC9" modified="2015-12-09" version="1">MDHAELIAELSEIEQMSPTERIALAKERRRLQLKKNEERERLLPPPPPRRPRLRFKSEIALLEATVRGDHIEVEKLLEEGANPNSHNEDGLTSLHQCAIDNNEIILRLFLRYGADVNAQDTEQWTPLHAAACCAHIDIVRILIANNANLLAVNADGNMPYDICDDDATLDLIESEMAARGITQEQIDQERGSGEKRMLDDMKLLHQRGLPLDSRQPDGSTYLHVAAANGYYDVAAFLLRVGVSPLVRDNDLWMPIHAAACWAQPDLIELLCEYGGDINAKTSSGETAMDLCEDAGTKAVIATVQQQEARKKSKFGVRDSRRQSRKRKKFESPQTGAANADTPLGVRGTIKRQSLRDKNGVTLARLEAQKEHTDLMRSWSKEDVSGRKDDNQLFNNMPSSANSNGSRNKDNTPGGGNKRMMGRGTSQKQKVISPDEWLRKLDAEENRNDYGFNEDDEDYRGIGRFERGRIGNSTSRKKRRDQQGSGNNHEMNGMKINSKDDLLTSSRDRNKKTCCCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8J5</accession>
    <name>A0A0N5C8J5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8J5"/>
    <dbReference type="STRING" id="174720.A0A0N5C8J5"/>
    <dbReference type="WBParaSite" id="SPAL_0001424000.1">
        <property type="protein sequence ID" value="SPAL_0001424000.1"/>
        <property type="gene ID" value="SPAL_0001424000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895531" evidence="4">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001424000.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="48185" checksum="4D841F510BE37B8B" modified="2015-12-09" version="1">MYHIRFVIVYAIFTIVCPEQNETNKLEEDEIPKNSREYWFEIMRNDSVIDKLMKSCFVPIQRSNERGGYYSMLDAISRLGRIAAYMRVFRRYIKAPNGLSDFSKKFPNYEFQFDVKIMEACTEHIWVCVDVISRTIESRAHIFFHADKNNVVEVFDLNEETLTEEITNNMFEQDYTIAYILCFLTTNRNPCLKHLPFCRYRVDSEYNKATHSKQFSQMYSQWQTKIFNFKNKHFMRDEQFYTYFGQHEPIDNLGEFEPWQCAEESFCPDPCCGKWEKRNETCIELNKCPTQKDGDSIIIKNCQFFTVMNRNFEDIVKNNWNTTCSCQKGKFEFDPDLQICVDVDECQNKIGKCGKNQECVNYVGGYACLCRPGFIKSKNGSCIGDNKPYKNDWHSHNYSPLRINNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C915</accession>
    <name>A0A0N5C915_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C915"/>
    <dbReference type="STRING" id="174720.A0A0N5C915"/>
    <dbReference type="WBParaSite" id="SPAL_0001439800.1">
        <property type="protein sequence ID" value="SPAL_0001439800.1"/>
        <property type="gene ID" value="SPAL_0001439800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001439800.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40719" checksum="4E1290963A68C0C4" modified="2015-12-09" version="1">MLSMEMRREIYELTIQNYRIVVPIFLTMCIMGVLANAIVIIALIKTKVRTPTVTIISSLSFSDMWTSSVVAASLLYNSYIPILYPKFETNPCISLTLELFRTGGLITGTLHLLIISIHHYIGITKPYYKRNYTTKTFIVCTLIWILPPLFLIILASSFQNQGFRDCWEFDNFYHTRVFRVSVSSIIVIIFFIIIFCYARMIYLLRLKRKKWQSRSASNKTKNDNKTVNTTVWICLSFFIGWAPATLQFSITCSTCDLMRYETIQGYKLIFYFSCLQLTFLLGKTLMNPLIYSLRIPEVDKELRKMNNGVKNFFANLKRSEITNQPKYNIKINEHNDGPASKTLIKENATSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C996</accession>
    <name>A0A0N5C996_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C996"/>
    <dbReference type="STRING" id="174720.A0A0N5C996"/>
    <dbReference type="WBParaSite" id="SPAL_0001447900.1">
        <property type="protein sequence ID" value="SPAL_0001447900.1"/>
        <property type="gene ID" value="SPAL_0001447900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001447900.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="71418" checksum="8AD9F7638080B612" modified="2015-12-09" version="1">MSTNNRGIGQLDLSLLETSAEGLKFSRKNIEAFLNNLKVVAESLEIRSSQSYNKDMAFESINDLNSSFQYNPNDEPIVGIESLNLYDKDSSFDDNKNVTPQRNGYKKNRNGIHDIQNSSSTPSSPKPPVSPRSIKESKIISEINVFLKSPRKMEDEFDEATVVRQFSQIAQCTAEESKENIRSLSSKISHLNNSYETSDNNVIPSFYFPYGRPLQYSDVTQLSNTIEQVFKRFPEKAIRAKDFGQVCASIGKPNMWSRILVNGCLGKDASDSDVVSYEVFRTYWLKLTSECFDDASIFIRLLVDGASSDSDSTPRRKYLVAEDFRPLISHVIYTIRDLDVLKNAPIFHSIYIDTVITRIFWRVSRTWLNKITAGELRKSNFLDVYGSLDKMENINDEHYFFSYIHFYVIYCKFWELDEDHDMMITPEDFVRYSDGALPSRVIDRIFKVNQYLKKYPKNSEVPGSLDYSDFTLFLLADENKRHNKSLEYWFRILDINGDGRLSFDEMVHFHEEVIRNVRVRVADCKSMKDTLCHAFDMISPVNDHCITLNDIKRKQELTDGELPQSCDDTDVDIVEWDNFCSKYYEMITDENDDSFNCGDEEEHLNFSEIDSDNSTNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9B9</accession>
    <name>A0A0N5C9B9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9B9"/>
    <dbReference type="STRING" id="174720.A0A0N5C9B9"/>
    <dbReference type="WBParaSite" id="SPAL_0001450200.1">
        <property type="protein sequence ID" value="SPAL_0001450200.1"/>
        <property type="gene ID" value="SPAL_0001450200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="255"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001450200.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41503" checksum="12B35174540DB21D" modified="2015-12-09" version="1">MSLNKSTIADGVVIKAIIKPNLGFMEVKDTYISELAVERTVTLSPRVLIRDLCRSVMEVYNLGHMADDFQVYIRHPNLEFYLLNAFFNDMNAEIGSVAPLFKDALTIKIFVPLQFCECIKMVKADGVYENFIKYLISRVGGKESQLSDEIVQYVKKEAKGCPIRQLPLEILTKMDEKLTHALQSNVTSMSEVVPPTPQRNHSLSFASVPRDNSISPRGVEPDDLKLCINDLESIIGDGLTTSSSQENHAEIHLGARPKKRVKYDKKVELPILERWYNGSSYTHDFARYAEALNIVSGRLESDRLTSKNIRTWFERKRVRDRRDQHGLTPVCTTELVKAAELGPEFEKRDVKIIALSIDDEECHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAG3</accession>
    <name>A0A0N5CAG3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAG3"/>
    <dbReference type="WBParaSite" id="SPAL_0001488600.1">
        <property type="protein sequence ID" value="SPAL_0001488600.1"/>
        <property type="gene ID" value="SPAL_0001488600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001488600.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14426" checksum="88FE6938929EE604" modified="2015-12-09" version="1">MVKIKIIFVLIILSNLSHLIITLGCFRSSNHINRLPIHDRYCKFNTPYCVKVTEGEYSYRNCDDLNVCVSLGNRCVSGVSYGGKYGELCCCSGDHCNSSIRTILVLNNKYCMLLFLFFTVFVNYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB58</accession>
    <name>A0A0N5CB58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB58"/>
    <dbReference type="STRING" id="174720.A0A0N5CB58"/>
    <dbReference type="WBParaSite" id="SPAL_0001512100.1">
        <property type="protein sequence ID" value="SPAL_0001512100.1"/>
        <property type="gene ID" value="SPAL_0001512100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001512100.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30717" checksum="A3AFF81738DF6920" modified="2015-12-09" version="1">MVGRKMNYFDAKEYCSKNFNANLLSIETKHQNNFIRDYYSFFGSKWLSASLSKEVKKNYILKWNGIYPITFTNFDPFNSLSNASPSLGCLKILENGLWVNSDCMVPSQFVCQKNLIQPIKMLIDCPKSWTLFNFNNACYKIIRTSSLGRAENLCREEAMIHGEEGSLASINSKEENEFILKLSLKHSPHLHKILLGGIGGGKEKLNWVWVDGNDFKNYQNWDKYMPREGQNMSSLVMLKSGKWANIRSNKNSHPYHTVAVCKLIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB89</accession>
    <name>A0A0N5CB89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal peptide peptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB89"/>
    <dbReference type="STRING" id="174720.A0A0N5CB89"/>
    <dbReference type="WBParaSite" id="SPAL_0001515200.1">
        <property type="protein sequence ID" value="SPAL_0001515200.1"/>
        <property type="gene ID" value="SPAL_0001515200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001515200.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="70279" checksum="0F2CB232A1596A9B" modified="2015-12-09" version="1">MSLQRNVIKKRWYILSILFLSLFFMSIFPGTIEGDDGTSKIFKKKKRHVYMSSFAYLLVTSDHNPELKGKKYCVNYNQFPYKEIPSTPEDAPKSAFHELKHYTFLNDRSYQNSTIVTSFNEIKINQMLNALPEEGINNMLFYFKKGNSNKERDTKYITSNFYLPQHTHYPKPIYFIYKKDFDDFRRIGNDSDLRFQFYRPKDSKFEYAEIFIFLIALIAITLGSKLGVYNASKRDVKKVTLPTTTPDYDLSVTSKCTENNSISTSSINVDNETKVPSRAVTSFCILIQISFLAGILILTYFFRNEMMVVFYIAVIIVGTFSIGTLFQTLSLIMFKKDLFKVSINDISENIINRKFDIGIFKEKIGFFGIIGYSLGLIITIAWYCIRDNPYSFLLLNFINLSISINLISLLEAYRFIWIIVVMIGLLFYDFFMVFVTPYITPDGCSMMIKAATGKDCQSPEQKAKMAHDEWEPLPSQEQNFMHTSIAPMVFLFPRMADSMLSCLDLSIELEYRPTILGMGDVVIPGIAVAFAHHADKFLFKQKTYYGLFSIIGYAIGLITTMFALEYMQMAQPALIYLVPFTLLSILIPALIRKEFKKFVFSDLSHNENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB92</accession>
    <name>A0A0N5CB92_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="STRING" id="174720.A0A0N5CB92"/>
    <dbReference type="WBParaSite" id="SPAL_0001515500.1">
        <property type="protein sequence ID" value="SPAL_0001515500.1"/>
        <property type="gene ID" value="SPAL_0001515500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001242">
        <property type="entry name" value="Leucine-rich repeat serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF169">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="17">
        <location>
            <begin position="982"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1786"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="802"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1818"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001515500.1"/>
        </source>
    </evidence>
    <sequence length="2523" mass="287920" checksum="AF3337D0AFE997EB" modified="2015-12-09" version="1">MSEEIGQLIFQAIIFRNLDLLNELIQANDVSDRLFLDDEGKTPLHTASECGYVEAIELLADTFPSSINYPANNDCLLKTPVHLASEKGYTNIVEILVRKGADLFLFDKDGHTALHLAQINSKYETANVIINHFQSVQETIKKLRDIFLEGAKIGMIENMEEVFSQVTTNIESKVFNGEINSDESVFFNTIRNGHLTFAKELLKFREHSLQEIENGDTVLHVAIRTGKYQIIELVLENFSFLMGCKNRKGKLPLHEACEINDVTILKTLLNFTYSPDLLNEIDVPGTDCTYNFICDLNETDEDLCTPLLIAVKNNNVLAVHFFLEFKINGKTGDNEIVEICPFVLDSYDCKGKTPLMISCANGNEPILRLLLQSGANPNLPIGVTDDDIQNMPSSTEGVFCCGSGALIEACKIKKITFVKILLHYGAYDHENKALCLASTLNCDDIICLFLSKLVRIDNDNSINKRLFHQGSNIPIPCILNWRQANLLTFPADFIFSAVHRISPKIRSIKGAFASLTKVDMSENLLESIPLTLLSLPSMKFLNLSNNKISSFESLDNFQCNVPVLENISLENNRFTSLPPQLFSSTYFPSLKILNVSKNQLKYLPSNIWSSTTLKELDASYNNLHDLPSLVVSFDRVGRSEHNIHRKYERQNDMKCIEDLLIPKIRNKSLDNRPISPSEETLPENVVEISLERINRWQNNLSLLKFDLEEEEVVGDRSEFNSLLLLNLSHNKFKEMPLNLACVCPRLIKLDMSNNELQSIGPVECFPHRLRTLDVSNNKLTKTFDPMTKHHLNCYASPTTNLNNNINNRRSRSKSVARNRRSLSTARNQIAQDVSSKKNPSCEVCIHKEHKQLEYLKNLNISCNELRNIPIFLPSLCITSPPEDVSSIRSLLIFPHLSTIDLSKNLIDHIPSSISNLNMLTSINLQNNKHLQILPSELGLLDKLWSLQLKGCPIKDYQIKSIIEAPNYKTIDLLSQLRSRLEDSRLYYHLKLMILGEKNSGKSCLLQNIIQEGSLINKKVNQSPSVQPSNIMNMYEFTLDPFKKSKVEQSNGPVTYKAWDMSGQKELINIQQYLITRRSIFIVTWNVNSGEHAFNQLQDFLIKIQVRSPNAPVIIVGTHVDEIISNSSKFPDDYLQYLEGKIKEKFINITDSDKKGLPKVYGTSFISNKTKDNIKQLISSIYKASFELRVGGSRIKTLEQKIPSTYMIVEKIVLKLRNLFNVSNREPIIQFNDLKYFINEKIVEKNGKNFRNDTEFNNVISFLHDNGVFLHFDDLVLHDFIILDVEWFYEIMCKIILFKDLLNSNGICEKGSFYKIASNIFNSMGYKKRSTKSSGKSGSLLLENLFDIFHKYELGLLYQIKNILIPSLLPEEYQLRAGYPGSNVKIKVKFNSWNLLMSQKLIKENEILRENLVMTSSIISPRIQSIVSKFSLDEAKEVLTRSFKKKDVDTSIKLIKPSVFPSIKDDGYHLKSMEDIITFQMSVKRVENNYITRLFLLQYTPYGFWSRLITRILDDHRITNIIPLLFHTNKTAISIKTMNDFLNDKFNGADWNLWQTGLECTAFSEIVFSLKQYLPMADCNDILYDKVNILHKDETEKWKNFSSDDFNIIELKIPYLIFNININDRLGSFETNPIIVSQLLSIISNNIDTLLEDWYPSLGTRFVHTSEGKLLVNRLVPCNKCLIEIKNPRRIEKSKDDTESIGREINPFTKSMPVKSSTMYNISTTPNIFKQSHYPLHTFSIEECILRAHDCALIKCPTHDILSIKIIAPDTIFLDIPEDLIIKSENLRKSKLIGRGAFGFVYRGSLKLKNDFHPDAALKMLEPINPGINVDDNTMNTYKISQEMWNRDPLQHCCKAYCSMRQELSVLVNLKHQHITSLLGVCVRPLTLAFELAPIGSLDVMLSNYRKSGIHLKMTVLQETIVQISKALEYLHLNHIIYRDLKSENVLVWQFPPPLATLNDVSLKLGDFGISRYSNGSEKCKGFGGTEGFMAPEIIQWNGEQEYTEKVDCYSFGMFIYELISLRLPFEGQEQFRERILEGARPQLFESDLLNPNNFLDLMITCWSKNPNDRPSLSEIVSITTAPEFRLLLDVVMIPETHLEMYSNAIGFLHTITSSNTFDQTFNELVGSFWMTVDFKNILSLKYNATGFMECKSLIIREEKIRITAMLHFQNYVLVADSNEYIRIYSEENFIELASWPLAIINEKNIKDKKIDIVMKMIEMPNEKDIIVIGMQNTILIVSLENGYMNPKLLSKLHVVNMIFTLTIPKNESGSREIWSGHDLGLIYCHILNDSYQFTYSSSMTHSPSNIGAIQKMYSSTISETSIVWSGGETQPIVFLWENRKIKKCVDCKKILPSSESLSSMDLEYSKEVKITSMALMEQKFKITQLFVGTSKGVLIIFDGLKLSPLYAMRPYIEEISIIQILSNPQLSKIISSRGNSIEGQIFSPSISTLSLESNILRHSTSSMEGDTISKINPLDSLPEANCVITVGKGYRPLIERFIGAKNFTTTNEVNTNLILWRTDDYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBQ5</accession>
    <name>A0A0N5CBQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001531900.1">
        <property type="protein sequence ID" value="SPAL_0001531900.1"/>
        <property type="gene ID" value="SPAL_0001531900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001531900.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39398" checksum="4FC8C51E3B1E1267" modified="2015-12-09" version="1">MFLECNELVNQNNKKFYKPEFVVKNNTCIEESKKALNTSTLYKKKLGDQLERGGFHVEIWSRSHVDEMYLCPGVLIGLKHVLTTLLCVGDVTYASDFRKSGKFEYQNKQNLFINFNMTKKNEDTFDGKFGKIDFDVFQFKNPIKNIILPVEKNQVKLRNLKAFVLMELQNVIPSSIHYPCIANTSSDHDKYKSSSSSNKVTITDHFFIYGAGDQYYRDGTNLWRRYKPRKREKIIFYEFSSAFECIYAVGYNLTADNNECLIISQKKISDYDIGAGCYRTYHLNSSSESEIKTELFGVIVSVSAFDPLNDYPGHNVVVIKKVLKRNILFKNINYIDNLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC19</accession>
    <name>A0A0N5CC19_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2116 family Zn-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC19"/>
    <dbReference type="WBParaSite" id="SPAL_0001542800.1">
        <property type="protein sequence ID" value="SPAL_0001542800.1"/>
        <property type="gene ID" value="SPAL_0001542800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001542800.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18192" checksum="1AE7E27CB462BABE" modified="2015-12-09" version="1">MSCVPRGNFQDPSNLCRTMCDEQYDSNDIIRDFFVGLFGICLPYLIQLVLYCWKKYHEQKNNQSADSQNDQVEAAAGQSAGDPLVTSNEAANQQVSTANEYVEAFYEQVEAVDDQAKTFKYQDMASGDKYRTSKSSNTSVSNTVTSKNNIYYIPFSDEVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC29</accession>
    <name>A0A0N5CC29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC29"/>
    <dbReference type="STRING" id="174720.A0A0N5CC29"/>
    <dbReference type="WBParaSite" id="SPAL_0001543800.1">
        <property type="protein sequence ID" value="SPAL_0001543800.1"/>
        <property type="gene ID" value="SPAL_0001543800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895662" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="570"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="912"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1069"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001543800.1"/>
        </source>
    </evidence>
    <sequence length="1186" mass="138616" checksum="196F0AD3366D36CE" modified="2015-12-09" version="1">MFLKLYWLGAAVALMPLLIQPNEVHRMELFPYVPEDINNKTFPFDLNVTTNSDMVLVKCPDTDYRHKNNNEMFGRNSKIFNPKGIFSPNASLFAWVPLLKTESGPTKLTCGEIALKDNANPYHKWTFNVMWKNGTDDENFMIKEGKILDISPKHENCDMSSKNHTIFGSKREGGFLLMKEYKNIQNLYVNQMFYYFDKFNNSEMIKEPCGIIKIYGNTPIIQIKPYESTLEAPKINEDTHKINSDGTDHQTFDVVLDMDRNVKYYQGEKIILRKMRYVEGVPQVIENSNISITSNFIINGYEIVELIYNSPSKNGYHTISKQYYFGPSERDHTITEKTIKYFKNETSKKPSCYLYYLNVGYLDKVDYNGTKGDYQTLNTTDGIKGKYKIDKTSVIFDEKEDGKTTISCTYKTLDGKITTTTKFVNEDTIASIENKRRKKIFEDQRRKNESIRLKFDALEKDKEKKQKEKEEVEKKWQEEKDKIHKEKQESNKSLYEKLSDKVGNFCAILLIIGVILLVLFILFFPLEMMYVKLLSPFLKMLTNKKKYPNVYVFWNNLTNRSFDNYCMAIRDREYLSYKTLHTAFLKAVKTDDEVDIIVSNIFDDTLVDCNKNLSRKLQAHYVYTDAQRRRYILSEGPRKDNQCSFWQMIYEENIAAVIAIIYDKKSEEDDGISKDLYWKSEKRTYGDITIAHHKKIKVNVLSVTGYQILLERKGGKPKSLKLYHVFNWKENDIPQSDLQFVSIYQEISKVAPKKNILIHSSQGTGARVYMLTYFACIYDALKSNNDVSCPLKVIKDIRNQRYGGNLVPYEFAFIIKALVTAFFNNKILVDFSSRRSDFISSYDNYFYDYLKRREQMGGKLKEFLNFVNIVDKGKIYECKSSIYTLGRFDPFIISILCSRFQNAIDNFEGGKDKKRCRYKSVQCLDKTGITVNGKPEADKDSFIHANKFEYTTKNNKNRKMILCQAPLVDTIDDMLDMILRYKVTVVVILVKPEEADASQKKWVPYFPVEHQVFETSNFCVSKINSKGLDKDFTTETECHLKNKKDDSEMKFTILHYQGWPEKNIPSEHMSIYSLYKRIISLRTDDYIAIHCSAGVGRTGTLALIIYLIDTIDYFPTFDPVERLRCLREHRYLAVQRFSQFVFALLVVFEHHKNEIIDMDSEAYDKFLEIAESVFKKEKEIENKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC63</accession>
    <name>A0A0N5CC63_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC63"/>
    <dbReference type="STRING" id="174720.A0A0N5CC63"/>
    <dbReference type="WBParaSite" id="SPAL_0001547100.1">
        <property type="protein sequence ID" value="SPAL_0001547100.1"/>
        <property type="gene ID" value="SPAL_0001547100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001547100.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12815" checksum="3883A33F31ED7C34" modified="2015-12-09" version="1">MHQKLSQKVPALVNRKEPILLNNNAKPHVSKRTVQKPRELGYETLSHPAYSPDISSTDYHFFKHFNTFLREKIFRNDEDTKTAFEVSSNLEAWIFMLMESISSYLVGNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDK6</accession>
    <name>A0A0N5CDK6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PLAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDK6"/>
    <dbReference type="STRING" id="174720.A0A0N5CDK6"/>
    <dbReference type="WBParaSite" id="SPAL_0001595000.1">
        <property type="protein sequence ID" value="SPAL_0001595000.1"/>
        <property type="gene ID" value="SPAL_0001595000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="429"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="545"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001595000.1"/>
        </source>
    </evidence>
    <sequence length="813" mass="91980" checksum="EE0BA8C3AF5BB9F9" modified="2015-12-09" version="1">MWQDKETPINSDSFWKYSFQYSGSQKNCRYLSVNCNSVVVSGSRDGIARALIEDSLSETPALKETEFYGTSNGYSNIPVHSVASFSPLTNEWNVIIVGYRDGSIKFYLHNQEKPFLNFFDHSATVCSLNIDQENGCLVSGGWDHNAFVYHLTASSPSPKWEKVFDLRGHSMSVWDGRTFPGTLNKQITGSADKTIKLWLDGICVSTFMGYCDVIRSVMSLSNEYIIATGNEPVIFVWHLDCPDRPYKTIKTESKSHLNTMEISTNPLNGITYCAVGGEEGFFQIFQITSNSVNPKDFNLISLVDGRLPVECIWKLIFMPPGPFTGDLILGGENGKLYVYTLTESRMAPQEVANKFLIESCEFAEIQDALKSKHQDNEYFTFVIEPEAGQGQLELKHKLGTDPRETVRSFLAKNNMSLSHFDQILEFLTSKCPDAANYLSNKKKINSGDADDIKRVKVLYDGREYDYCFDVNIGDKNVKLPYNVGEDPAEVASNFCEKNNLSVGSLKTFTDFLYSQVPELKNSPYRNSGNNFNRPDKKEVSRPINCGLPITKLVEFKDFEGHNIAKMVSRLKSASERYTDASNSLSEDEYEIITNFFVTRNASNLLFDDGKILRKLLLRSGEDMLPVLHLIYLSLNFEELAMFLQNKQRIIGIYKNILCDESASPNFITMVFRGLANSCKYRAYLNVYQSEKMFFVNKAFYYATSSKVITQVAALTFLLNFVTASRGNDFQVSEIVVALLKKFSTVSICSQLFPQGIELILQIWGNMLYDRPDVIQTSLKNDGMNVIKVLKDRSSEGDSPLYARTIFNMLQRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDP7</accession>
    <name>A0A0N5CDP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pb-reticulocyte binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDP7"/>
    <dbReference type="WBParaSite" id="SPAL_0001599000.1">
        <property type="protein sequence ID" value="SPAL_0001599000.1"/>
        <property type="gene ID" value="SPAL_0001599000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001599000.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39670" checksum="38C7187F6A4BFDF9" modified="2015-12-09" version="1">METSKRKLNGDFCEKPTSDIDPYGILREFLIFPDDDASIKQEEDVFNEEMMDEGVGSGGSSKVNANYDSSTLSENNDQTDITDKESLDKGEKLKVNERKIFCTFNEQLATQGDSEAFMNARLKGESRRQLAAKSSPEEKQLQHEEAWKEDINDLYNLLEEEAENKLRGSCNSLKNTILDVDERVMKRNKYIRRNLTKRQVKISCEFFLLDVIKRCFNDYIIGHRIQNDDLLVKFYRYDNRMLALRNTLRSHTYFGKLITLIYNTRLIYGKIIPIPYLNDYIRNFVHSTCPHFVIGRTKKIARHYIRNYSWMYEEYNRMRKNNKTNIIESEGITDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE17</accession>
    <name>A0A0N5CE17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE17"/>
    <dbReference type="STRING" id="174720.A0A0N5CE17"/>
    <dbReference type="WBParaSite" id="SPAL_0001610800.1">
        <property type="protein sequence ID" value="SPAL_0001610800.1"/>
        <property type="gene ID" value="SPAL_0001610800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="487"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001610800.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="98501" checksum="E837B38A9C747F48" modified="2015-12-09" version="1">MEAGTGGWPGGQACLPAVQLALEDVNNDDRILKGYELKLHHYNSKCKPGLAAKQLFELLYNPPVKLILLSGCSPVTTVIAEAAPVWNLVVLSYGASSPALSNRARFPTLFRTHPSANMHNPTRIKLFDKFKWKRITILQSVEEVFTSTAKDLEEECRKKDIRVDKQSFYGDPTDAIKTLVRQDARIIVGLYYVTEARRVLCQAYKHGLYGRKYVWFLIGWYADTWYLPVRDEQLNCTAKQMEEAAQYHFTTESIMLRKDNKKAISGITGTKFLQRLKKELNTNPSETGGYPEAPLAYDAVWALALALNCTLNNIRDSTSVEEFTYNNTNVAGQIFDCVKNTQFQGVSGKVMFSEAGDRIARTQIEQMQNGKYVITGYYDITNNHLEWFNNEKWYGKGPPADSTIIKRHLLKVNIFLYAIVCLIAVVSIGLSVFLFIFNKECINRSIIIQSQPKCNDLLIFGCILCSGSLFLMGLPSGIINIPNDLFPSLCYAKVTMLMIGFSFAYGSMFAKVWVVHRMGVNENQKIVLDDEGKSEANWPWSNIRLLITSMLHTTIRKISTHTSLMQRKQNQLNQPIPSFKFQSIVATFVCIDFVLLLIWIFIDPLQRYEQYFHLKVSEEGIREDIKYQPVLELCQSKHHEVWIALILSYKCLLLVFGLFMAYESKNLKLRYVNDSRFAGMAIYNVAILSLVTGPVVCLLIRTQPNANFAFISVTVLLCTFISLGLVFIPKIRYVCRIPSEHDEHDFLSVKGSIPEQQHFESILKENVDLKRQIHIKEDKIRECQNVLIRRRGHNLSSVGSFENISSTCFKCIDGISINKTSNESSKTISEGFFPSSSPTTFTTTALIETHNNISEDTDNSSNSCEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEA7</accession>
    <name>A0A0N5CEA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEA7"/>
    <dbReference type="WBParaSite" id="SPAL_0001619700.1">
        <property type="protein sequence ID" value="SPAL_0001619700.1"/>
        <property type="gene ID" value="SPAL_0001619700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001619700.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="64394" checksum="113FD9971BB63A49" modified="2015-12-09" version="1">MKPKEASFLDLMNNGLVRKEIFKMLSFFHDISNLSRTCQELNWITDSEIFLRTMSFYHDFQSVNIRIKEETPEDLSVVKMDNIIFEKDERFFLEKNFFNKYFGETILKSNCTTIFYSNWIEEFAEDERKLFIDKLSNEMDLNCRLRSNTKILDFMIDFSYHTSMILNVLSSMKHQNISHIKVSDIIFMEHNTNVYKELKSNIFDGFPNFHKLEIECIFFVYYYKRFIKNGNILEKIFSELSKRKNATLILNFSHCEYDRLINFVYMILEITRSYKIKLKCNIMYVLESIDGRNNINWTIHRSIYLPIKLYLTSLTITIANSKYFRDIMKSLQNFTNLETLQLEFLFFDIKKNIKVEERIHGDCMSLKNLTKLTNLKLYFAEFINRNNNLNVKKFCSNLMYLFTLMPKYVHKLELIVVPILTNEVAKIINEFLPNLEILVTYRVLFYEADCLLPLKNLHTLICHERLPNLIPNTIELLAIKQKISEENNAIAEENQKLIDAYSKNFTKILFDIDGRYVFFNNIRKWNFYKHVIEESFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CED5</accession>
    <name>A0A0N5CED5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CED5"/>
    <dbReference type="STRING" id="174720.A0A0N5CED5"/>
    <dbReference type="WBParaSite" id="SPAL_0001622500.1">
        <property type="protein sequence ID" value="SPAL_0001622500.1"/>
        <property type="gene ID" value="SPAL_0001622500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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    <feature type="chain" id="PRO_5005896002" evidence="11">
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            <begin position="17"/>
            <end position="561"/>
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            <begin position="220"/>
            <end position="243"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="250"/>
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            <begin position="432"/>
            <end position="454"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="466"/>
            <end position="496"/>
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        <location>
            <begin position="17"/>
            <end position="140"/>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="215"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
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        <source>
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        <source>
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    </evidence>
    <sequence length="561" mass="64358" checksum="6643E55DA3C390A4" modified="2015-12-09" version="1">MKFMLLLLIIFQLTYSYDYPKCVPITSEYCQNVLPYKITRYPNLAGDENEKDAINSIASYNMLVDTGCSQQLKFFLCSTYFPMCTDKVPIPIGPCRVICEEVYEKCEPVLRDFSLPWPSVLNCTKYPLENGYRDEVCMGDVTSKENEKFKVEDESDKSDESIEDLTLYNKDPLSNKSPIQSLKNCDIATNVYINKTNRCVSQCYAFESVHQQQIEEYARYSLAIISFISLCISATTCLISIIWKYNKMNYFNYSLFFSIIFFSLASFIKLINIQFRDSISCTTYNHISIIVVPELHHIPCVLIAILTYYFGTTARLWSVIASFAWRRSLNINTKSEDKTEKSKFQFRTATIACTLSFPIILLILMTKSTNVDITTGLCNVSPGYSNLQNLFNSLREIVFLIFSLLPIFSGCLKEISPKTLPNNYIVTQSKPLLRNTIIILFTILYFIFTTYWFYYSVQLFSSSSEIHWDIIIATNTFADAILGIFVSILFMVSVIVNHYCSTHISLSNVQKINNETTVYLPTTLPPPPPRYIVSRYGIHNNSVINDDYDNAMMSGTLRKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEG7</accession>
    <name>A0A0N5CEG7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEG7"/>
    <dbReference type="STRING" id="174720.A0A0N5CEG7"/>
    <dbReference type="WBParaSite" id="SPAL_0001625500.1">
        <property type="protein sequence ID" value="SPAL_0001625500.1"/>
        <property type="gene ID" value="SPAL_0001625500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="16">
        <location>
            <begin position="26"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="175"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="430"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="531"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="660"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001625500.1"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126888" checksum="78D294F0FDF04812" modified="2015-12-09" version="1">MKKDISDKLSLEDKWNLIPSFLQVRGLLKQHIASYDYFVDVDIKNILKANNKITSDASPYFYVKYLDIRVLMPQAEEGFGQVVETITPHECRLRDMTYSAPIVVDIEYTRGNQKVIRHNLTIGRMPVMLRSSKCVLRGLTDKEMAEAQECPLDPGGYFIIRGSEKVVLMQEQLSKNRIMIGRNSKKELICEVLSSTSDRKSKTLITTKKGRYYLRHNQMTEDIPIIIIFKAMGVGSDYDILSSIGEEDNFISALTASIEEAQNADINTQSKALLYLASKMKLKKNYSGGTSSYVMREYDALDFLRNSMICHIPSSSSDMKMKSIYLGLMLRRLLEAEQNICDCDDRDFYGNKRIELAGSLIALMFEDLFKRFNTELKKVADNSLGKTLAAPLDIVRHMRQDMISNGLNNALSTGNWTIKRFKMERKGVTQVLSRLSYISALGMMTRINSTFEKTRKVSGPRSLQPSQWGMLCPADTPEGESCGLVKNLALMAHITTDSEEEPVLRVLYNCGIEDVRSLHYRSVHLPNTFMVYLNGSIVGLTKTPKKILDTIRVVRRSGFLNEFISVSSNTQQKAIYISSDGGRLCRPYIIIKNGESAVKQIHLDELRTGKRTFDDFIADGLIEYLDVMEMNDSHIAVYEKDIKHDTTHMEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGSIGYNQQKRIDSLMYLLVYPQRPLVKSKTIEFSNFEKLPAGQNATVAVMSFSGYDIEDALVLNKASLDRGYGRCLVYKHAKASIRKYPNQLCDKLMGPSIDMATKKPIFRYGAVDVEGIVRTGARIFSKQVMINKFMPTVSSGIYNTSSEAIDVGYKDVAVSYKNPVPSYAERVLLTYNEEDAHLIKIQLRQTRRPELGDKFSSRHGQKGVCGLISPQEDMPFNDLGMCPDVIMNPHGYPSRMTVGKLMELLSSKNAVLTGRYHYGTAFGGDQVKDTCESLAQHGFNYLGKEMLTSGITGQQLSAYIYFGPIYYQKLKHMVLDKMHARARGPVAVLTRQPTEGRARDGGLRLGEMERDCLIAYGASMLLMERLMVSSDQFQVDVCSVCGLIGYGTWCQKCKKSGQMATIKIPYACKLLFQELQSMNIVPQLKTERYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEY3</accession>
    <name>A0A0N5CEY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEY3"/>
    <dbReference type="WBParaSite" id="SPAL_0001642100.1">
        <property type="protein sequence ID" value="SPAL_0001642100.1"/>
        <property type="gene ID" value="SPAL_0001642100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895819" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001642100.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12811" checksum="82352D72E5689B4E" modified="2015-12-09" version="1">MKLSRLAILLFLLIFYRLIEARGGHGGGGHHGGGGHHGGGHHGGYGSHHFGGISHGGGYGWRHFGSGYGSHSFGWRRPWYGGYGYNNWGSYGNYGYGNNCRVVGLFFRRIRCFGFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH84</accession>
    <name>A0A0N5CH84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH84"/>
    <dbReference type="STRING" id="174720.A0A0N5CH84"/>
    <dbReference type="WBParaSite" id="SPAL_0001720500.1">
        <property type="protein sequence ID" value="SPAL_0001720500.1"/>
        <property type="gene ID" value="SPAL_0001720500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="263"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001720500.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57654" checksum="E020882971D928B3" modified="2015-12-09" version="1">MMQNQPTTQYALFNQFSTTAGMTKADDPRELYNEQELPLGEEERKMLELFYKERSSVQELFYKERSSYMVRSRPYTRGRNVPIIYVKIEGCPTFAFVDDGSDVSLMSKEFWKKMKECHHKINTNDRIPIASANSEMKTTGSAFLRVGLAAHVQSKFSLKGRSPLMEDLLYITKNTSIHLWNFGTRPFTILKNTPICLATILKPDEVINAQDEYIAPEANWEEDLPDVKRTKPLSDKELLNIVEIPNQLKPLILKYKEVFYEYIHDPGRYTGEIKHEINLKEGTKKKSGEWRKVVDYREVNLVTKEETSVLPLIEDILEKVAGKEVYTTIDLASGFFQIPIERKSKEITAFITPKGLYQYNVTPMGLSGSPSTFQRVMENSFGNMRDSVVVYMDDIIIFGKEETHKQDIEQVLKKLQEIGMRAKLRKCNFWQKRTEFLGHIVSQDGIEINSKKIEAIDKMIAPRNKKDLRTFLGAANYFRRFILNYAKVAAPLTKLLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHA9</accession>
    <name>A0A0N5CHA9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytosolic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytosolic galactosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytosolic glucosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytosolic glycosylceramidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-galactosyl-(1&lt;-&gt;1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:59292"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-galactosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:43908"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:57934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:43909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59284"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:59285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59288"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:83992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:59289"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHA9"/>
    <dbReference type="STRING" id="174720.A0A0N5CHA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001722800.1">
        <property type="protein sequence ID" value="SPAL_0001722800.1"/>
        <property type="gene ID" value="SPAL_0001722800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001722800.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54343" checksum="D1AFE65D5F554030" modified="2015-12-09" version="1">MDDNKLKIFPKNFIWGTATSSYQIEGAAFEDGKGKSIWDDFVRLPNKIQNNDTGDVACDSYHKIDGDINMLKQIGVQFYRFSLSWPRIFPTGVGKVNKAGVDYYNKLIDKLLENNIEPMITLYHWDLPNALHYKGGFLNDNFQNWFVKYADFCFKTFGDRVKKWITFNEPYCTVSFGYSKGFVDMAPGGFNEHSHWTIYQSTYNLLLAHARAFRLYRYKYKKQQKGEVGITLVHFGITPGNPSETDIVENVFDSSFGIFAEPIFGKNGDYPEYVKKVHEEMRKERGDSDTTLRQFTDKEKALLKDSADFLGFNYYSPLIAFKGRNVVPGVTGQFSNDFNFTLTTDTKYPQAGDGWIRDAPELFKDSLLLIKKKYGNIKIYITENGCMDKASEGNVDVSRQKYIKGHISSLHDAITEGVNVKGYTLWSLMDNFEWHEGYGTRFGLFHVDFASPNKTRTPKDSVAIYKEIIKANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIB2</accession>
    <name>A0A0N5CIB2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIB2"/>
    <dbReference type="STRING" id="174720.A0A0N5CIB2"/>
    <dbReference type="WBParaSite" id="SPAL_0001756600.1">
        <property type="protein sequence ID" value="SPAL_0001756600.1"/>
        <property type="gene ID" value="SPAL_0001756600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000667">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001756600.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12260" checksum="10E6E3012157049F" modified="2015-12-09" version="1">MEMIEKGNLRDFLRSRRPNSEDNVDNKLIPSSQKLTNWAAQIADGMAYLESHKFCHRDLAARNCLVHRDEIVKIGDFGMARDIYYHEYYQPTGKRLTLVRWMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIQ7</accession>
    <name>A0A0N5CIQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001771200.1">
        <property type="protein sequence ID" value="SPAL_0001771200.1"/>
        <property type="gene ID" value="SPAL_0001771200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896116" evidence="2">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001771200.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13770" checksum="1ECF3A6EB67C2A19" modified="2015-12-09" version="1">MLFSNHIKQYILFIFFISFIELVKFCLPSESPTVPKNGRNSGSGNSLTPSRHSTTNTRRYVKKELTYRANERRQQILRRQQANRNLNYQRRNSFESRCLSGIIASIKIQKGHSPKEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIU3</accession>
    <name>A0A0N5CIU3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIU3"/>
    <dbReference type="WBParaSite" id="SPAL_0001774800.1">
        <property type="protein sequence ID" value="SPAL_0001774800.1"/>
        <property type="gene ID" value="SPAL_0001774800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001774800.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16553" checksum="69E67F1D94F80A27" modified="2015-12-09" version="1">MYLFTETILSSCPHEDYCRIMTILSLIALFFQTIVAFTLIKEWKTTKSEYTKFLTIIRTIHIFYNLLGSTIGEFRVFLPKLTSVCHGVIRFFGDYACGVSFNLFLMFLFVETFSVVYGFNGQYNIICRKVKFHENNLFQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B362</accession>
    <name>A0A0N5B362_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B362"/>
    <dbReference type="WBParaSite" id="SPAL_0000051400.1">
        <property type="protein sequence ID" value="SPAL_0000051400.1"/>
        <property type="gene ID" value="SPAL_0000051400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000051400.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17960" checksum="A86B435EA70AE8F1" modified="2015-12-09" version="1">MEPSINDLLTWYWQIELKSKRCPSEKKRRELILESIPDELLEDYSADDLDEKDSSALLHVASQFVKRKWLLEPLNKRFEMIGQNITISTRTNPYTYALKKIKNSAELLGFDDDVDNMVIQRFINLLPRGVVGKENLIQPRDMILTNWLTYAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3J1</accession>
    <name>A0A0N5B3J1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B3J1"/>
    <dbReference type="WBParaSite" id="SPAL_0000064400.1">
        <property type="protein sequence ID" value="SPAL_0000064400.1"/>
        <property type="gene ID" value="SPAL_0000064400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="499"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="974"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000064400.1"/>
        </source>
    </evidence>
    <sequence length="1207" mass="138664" checksum="18750C2F72B3A070" modified="2015-12-09" version="1">MTRSSTFTYLVNTWRDLLGLQDNMEVPPSTTEWLQNGRLRKTKLAETIKDNMEVLKQTSTEFQNVFWFXNITSRIKELTNLNMFYDGDIREFISKVETVCDTDEERLLITPSYLKGIAKSAWRSIPDKSDWQIVKEKLINAIDPSSGKKSSLELKNEIIKMTPRDKETGRYFLIRVQEKITLAQEELKKCWSCDEQAELLLQALQNTYFGKILMRKTKENDLDYAQIADAFLTLGRETYVKKKFSINENNFKKDPKRDFNKDFKKNKKGFKKPSYNKVNHITASSDEEELLSSSEINKIEHYICFLVGNTPIVEIFLHGITQKALIDTSATTLVISVKLFNMLLEYSKNKNITKFTYRPKCPVIIRNASGKEIKSFGIVSLKFGKTNKKSSKTDFIVADLAKGIDIIIGINLIFSKNNKWILKALNNIQLSEKLTHTVYKISIFDKYPTIIASDDYNKPSEIIEPVALELNDQVIIKEKARPIPFAVKDKVNAMIKQMVNAGILEKSKSPYSNPALIINKDGKLRLVLDSRKLNSILKKNSIPLPRIHDTIYKMGSKSMFCCLDLAKIYLQIPLTQSSRQLTAFFIPEVGHYQFCSLPLDLTVTPGEFQARMEHIFRKQIDDSNVVIYIDDILIAGNSKQECETNLHEILSILDKYQLKLNPSKCNGTVKISEKNSNKFLNFSTPTTKKQLASFNGLFTYFCFYIPQAATLLKPLKDAENREKFQWLPNDDIAFQKCKAAIRDAKILHSPNMATALSNKESFTLCTDASGDAIGSVLLQNHKVVGFYSRTLKGAERNYENYVADCLSRCIQPEPISPQDDVEEFPEEHIIAIETTTAMLNEPWTNLPNRMEWSAFQESDNKLNQLMKAIKNDEWSISTSSPEMNFLLKQKSNLIINDKHQLTTKDGKLILSHTLANKVALFCHKNHESYSNILQRMNKRFITYQLPSLIQNIIRSCSICQITYQKRSKTHNWKECTKPLQRGHLDIGHCSLYKSDFFVLKDSFSNFLFADWIPKQDASTICNKLQRIFELTGAWSELVLDNQTSLAGNHMRQFLSSFGTKHTLSIVKQHNTNGAAERAIRSIKDRLYKEKTLGNGKEMALRNTLTRLRCNPYKDGTPYTKFYNDPERLPNKTLELFLDIGTKEEIFSPPLDGYFQSKLNINKQWSKAKILKKLSKHTYLIEDIIDGTHHIRTDKCTKIMHKPSGKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Q1</accession>
    <name>A0A0N5B3Q1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Q1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3Q1"/>
    <dbReference type="WBParaSite" id="SPAL_0000070400.1">
        <property type="protein sequence ID" value="SPAL_0000070400.1"/>
        <property type="gene ID" value="SPAL_0000070400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF137">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="4">
        <location>
            <begin position="284"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000070400.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58705" checksum="25D9D48BCEE0EE54" modified="2015-12-09" version="1">MPTGLAYLREIGMKVINDEILQLTIPTITEQIDQGQVSISNTYIAKYWAPTDYSLDLSGPDSFTWTLSKMHIRAVGEFEARLTSPLLIPTVPLKGEFETLLGHISLSMSVRLFRSPYGSPQVQSTKCASQVGYVDLNVRNTGVITDFFINSFKGFLISHFKPTVEQRMCQMIEKIINMDMNSFLMTMPLKIRINENNLDIIGQTFDKTRKPFLRQRLESRPLRNGSLINFINDLRDKNLVLDYSIMRNPFINHGTITMVGKGEISYRGMGGTPFYPPNIEIPQPHGVHMLEFYGTDYVANSMLYHAYRQKYMDIVVGPESSGKLKEILLTSCTSGFCIGEFLGDLSTQFPDREVEIKFAARKAPILVFVTNRARFRLHGRMNMYVRPKNSTQMKTLIIRSDTIMTANVYLQIKNSKIVGNATVENLDFKLIESKISNVDQSVFQDLGLFGAEFIEKLITEILEMGMIMPSMKGVILKSPKLSIHERYVKVQTYFKLDEHYAGSIIQGAVKQSLRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3R7</accession>
    <name>A0A0N5B3R7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3R7"/>
    <dbReference type="WBParaSite" id="SPAL_0000072000.1">
        <property type="protein sequence ID" value="SPAL_0000072000.1"/>
        <property type="gene ID" value="SPAL_0000072000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000072000.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16875" checksum="B61912C6AA4FF7D9" modified="2015-12-09" version="1">MSSSNDIEKGKYTQVPGKRASVVKQSICEIPSFTPKASVAGRLSTTIIPQKQSRIIPPGGQLFLCIIGSGLSLSICVWLAFFSNDVKWRRFLIASGAAVCAFMFAGLAISSMRKRNNDYKETISPALLIAQRRATLTAQRNSHAIPVKESSQNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3V4</accession>
    <name>A0A0N5B3V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3V4"/>
    <dbReference type="WBParaSite" id="SPAL_0000075400.1">
        <property type="protein sequence ID" value="SPAL_0000075400.1"/>
        <property type="gene ID" value="SPAL_0000075400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="181"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000075400.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="45596" checksum="65510172149FAE29" modified="2015-12-09" version="1">MENRKYDNKSKVIKNINDMFRKCSTLDPDLIENCNESVLEFGTYAFASYFIHRLENNKIVQEGYKIVKKMFHEIINEFRLLVKEKKNILDKITIKNYIKKLNKIKLNRNKHKKLGDLKLMKKCYGYFKFSNDMSAEVMIYKINYFESLLPKNDAKLRKRCVDYIVYGKTGGVDIMMLTDKNAYFDPDLNAVVINPSMLVDPCFDIRFPMSLNYGCLGAIIGHEIIHGFDAIGIHFDDNGKISQNITSEESRKKYKDKSDCLGKQYTNETLKQFGNDYRKFRVLDENIADNGGIKIAYRAYLKYLKKIGGKESIIPHFVKFTGKQFFFVNFARFFCSPDNQPINMNNENSEVHLLGSVRVRNTLSNYKPFSEAFKCKVGTKMNPKDKCEVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B415</accession>
    <name>A0A0N5B415_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B415"/>
    <dbReference type="STRING" id="174720.A0A0N5B415"/>
    <dbReference type="WBParaSite" id="SPAL_0000081800.1">
        <property type="protein sequence ID" value="SPAL_0000081800.1"/>
        <property type="gene ID" value="SPAL_0000081800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="409"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000081800.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59583" checksum="261A6D6D39A33373" modified="2015-12-09" version="1">MVLFCWKRNPSKSKKRKEKKALEKSDSIPIIKDSENLPLTKESAVVSSSRCVNENVCQDIEDTTINYEERRRQKIAALERRRRLREKSSARLKAKIMEKKAPVDTVGTTNKFPGGTVNASTTSSGVDSQLIPPIESKQVASDCTPLPIATESREETEKGNTIALVSWINKLLEVDRHTSENTRAFSERARKRADEVFKTILKNPELPAETVLSSRDCPEEMLKREQEWEDLLSKAKSCVKSLGILEKVKTTVGGEPNIAVEDLRVDADIGLQRETTDVLLGFSPVWLHLAIECVFDVQLRIVNYSTSRSVFKSFIRNNIFSDERITGSKRFCPTGTKASITKLGVKKLQHHFIVKTVQLLAVIEYLQRFNIMEPANPPIFTPRSRFQSTKDIVGWIRSTFISPKFNLANALKKIDIFFIYEQAYYHNHFYVVDDISKDLRDGFILAKVAERIFEIEDGALLSSLRPPNGDRLRKLGNVRIVLKSMKEHNMDVDNIKAEDIVQGEIPQTMELLQKMIGVSEVRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4G9</accession>
    <name>A0A0N5B4G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4G9"/>
    <dbReference type="WBParaSite" id="SPAL_0000097100.1">
        <property type="protein sequence ID" value="SPAL_0000097100.1"/>
        <property type="gene ID" value="SPAL_0000097100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000097100.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14308" checksum="B10B4478ED3C5E29" modified="2015-12-09" version="1">MEENVTGILKVPPLDSLKNGAIFGTVTVKCNKEMIIKADFDYNIAKPYEIIVNYTYSITKENIVKNIPKDCKEPNNIIRSKIDICEFPYNSINPNPEKDKWRDVTLPTESELDHIDSHLGGLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Z2</accession>
    <name>A0A0N5B4Z2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0000114033.1">
        <property type="protein sequence ID" value="SPAL_0000114033.1"/>
        <property type="gene ID" value="SPAL_0000114033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000114033.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18505" checksum="7BCA91A544A33B62" modified="2015-12-09" version="1">MDTATKFTIGFSIQDLKGTTIAKCLEEIFTHHDPPYSVRCDSHKSNTSQIIGIKTVFTSSDTPHINHFLYDGSLSTYERPPIWRSSLPDEIMKEDVETTAALRKQETPFPNNNIIRMRSISVAKETLPRTGKKLHFQIQGRVVSVKPNMTYKARVKKHCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5N8</accession>
    <name>A0A0N5B5N8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5N8"/>
    <dbReference type="STRING" id="174720.A0A0N5B5N8"/>
    <dbReference type="WBParaSite" id="SPAL_0000138300.1">
        <property type="protein sequence ID" value="SPAL_0000138300.1"/>
        <property type="gene ID" value="SPAL_0000138300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000138300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16262" checksum="04558687BCF5DBA8" modified="2015-12-09" version="1">MVIEDDNNKEVVICKNMKGNVSLNGDEFTEFTESLLQDCSCSFNHHASTSKQETFINKEDKKVNDILSIITSDTDYKKLSILSNKFNTFNYNVPKRNLFLTEENQNFLNKLKYFNKYEKCSCIKNEDISSNDDIVNIGCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7X6</accession>
    <name>A0A0N5B7X6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAC-A/B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7X6"/>
    <dbReference type="STRING" id="174720.A0A0N5B7X6"/>
    <dbReference type="WBParaSite" id="SPAL_0000215000.1">
        <property type="protein sequence ID" value="SPAL_0000215000.1"/>
        <property type="gene ID" value="SPAL_0000215000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000215000.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22174" checksum="67DDAF217CB00F1C" modified="2015-12-09" version="1">MVDDKPAQEVKHEEGNDSDIEDVPELENMTEEQRAAQIESIIANGLQGGSEREAKQSRNEKKSRKLFAKLGLKPITGVSRVCIRKSKNILFVISKPDVYKSPGSDTYIVFGEAKIEDLSQHVPFQAAERLKPTEPSVSEPTVSKPVCEDDDSDGEDADATGIEEKDIELVMSQASVSRKKAINALKKTDKDIVNAIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Q5</accession>
    <name>A0A0N5B8Q5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8Q5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8Q5"/>
    <dbReference type="WBParaSite" id="SPAL_0000242800.1">
        <property type="protein sequence ID" value="SPAL_0000242800.1"/>
        <property type="gene ID" value="SPAL_0000242800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17382">
        <property type="entry name" value="MFS_SLC17A6_7_8_VGluT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000226">
        <property type="entry name" value="Vesicular GLUtamate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000781">
        <property type="entry name" value="Vesicular GLUtamate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF206">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000242800.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="66794" checksum="74B3EFAB28B53948" modified="2015-12-09" version="1">MSVSVLPSADDRLAHYEAHDKASKVKAAIDSSRKSVKRLARGTAERVSRVLSGGTIENIEQLKSNNEPKDQLFLKKTRWQIAIMANIGFLIAFGIRCNFGAAKTRMVSNFTDLNGVTHPKEFHWTASQLGLLESSFFYGYAASQIPGGLLAAKFAPNILFGLSVSIASLINIAIPIALYYHPSTDGIVVALQIAQGLSLGIAYPCMHGVWRYFAPPLERSKLVTTTFTGAYLGVMIGLPLSAILVSYISWSAPFYFYGIFGCVWFIGWIYISAPSPKVHPRISEAEKEYIINSIGPVASSGQVTLTTVPWKEIFLSGPNWAITISNFCRGWVFFLLIGNQLTYMKDVLKMDIHNGGLFAALPQLSLSIVVLFGGQASDYLRSTGKMSTTAVRKLFNTIGFCCEASLLCVLAFVKNPVIAIIILTLSCGLSGFTLSGFNVNHFDIAPRYAPILMGISNGVGALAGLGNIVTEHLTAHDPAGWKECFLLAMGIDLFAAVTFLIFGSGELQDWAKEEEPTQTMSEIIRRVSTAVRRMSTISRKGTPGGRRTGIQKLREQNGGVDGISNFGASIGSVSFAHPVVTLPEGEELGEIEKNTFMMSNASILNDNRRAQHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B981</accession>
    <name>A0A0N5B981_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B981"/>
    <dbReference type="WBParaSite" id="SPAL_0000259700.1">
        <property type="protein sequence ID" value="SPAL_0000259700.1"/>
        <property type="gene ID" value="SPAL_0000259700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000259700.1"/>
        </source>
    </evidence>
    <sequence length="680" mass="79382" checksum="E8A626841B6F925F" modified="2015-12-09" version="1">MWILFFFLISQTLTKEWIWDGNKRWQNVGREIVYIGSAEGIWQGSVGEISKRLTKGITFLNYMTLKNIKIFEANITNYKPGRIGVHLAGIGEKHEHNAHKQIFAVTYMDRNYFFNSHHTTCQISYCENGLFFISNINADDMYKAKVDDFEEIFYLKFVTSDMNFRLDRFTITENNFPLILCPYKTWVGIQSGTKFIPYETNGIIFSNFFERQILLPGYPRSEDSDIFVCGYIKYEDGSQLTISHEIEIKDYYKIDSIKSINDFQHIWKCSEGEATTDYHYFIYSYNFEGNHKMKHILKDSVDKNKFYYNDTMYLYKETYTKDLKNVKNRIGHGYVMNPIKPDCRWKLPQLKFKIRLVSLDGSKIFDSKDGIQIMDVRENMLNKDIYYKCKIVIEEATRHPFLSNYYDQIMEVLLVSKDDDGNKIFHDKIKFDKSFDGFKKYECEIRYKNKDFKYNHPIEKLSFLAIPSNVSITNKNETWRVKDDVVIQCQRKISNIGEIDGIRLQLSKNIFIEYSNVTTGGIFNVVGHFVRSNYRNLIKSKKQKDMDIKYLTTQCNYKVKGGKRFSIVKSGTVLQKTTIFKIKKVFKDKGNDKTLLIGLIIGILILLLSILFAIISIHYVKYMNKKRRNGNDSSSSTTTSSTSSFTSSLSGMSLTNTTAKKTQSKVSKESESNLVIILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9B1</accession>
    <name>A0A0N5B9B1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9B1"/>
    <dbReference type="WBParaSite" id="SPAL_0000262700.1">
        <property type="protein sequence ID" value="SPAL_0000262700.1"/>
        <property type="gene ID" value="SPAL_0000262700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000262700.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33008" checksum="7E3F93B707D32089" modified="2015-12-09" version="1">MNPESLQTISKRNILCQMYNDKNLHRLQVLPAYLVRHLKQLKNEIDIFYKVHINFIDVFAMSLVSIDPVTGSFDRLGTIKNLRRYSQPAVYFQLCAVNAMDDETLEVWLFSLTELEHHALLISDNEVVAGRALEIVGREGIINYEHCAMKSAYHGWLPALERSLMRVQEPGNGLLSRCILMAIRHHHYHIANLLECYEFSDSFVYFFPNGFVPVDFVISLLDGSLINIEIGRTIAKDLIEWMPKIEILKLSEALKKTSCCPYILSELETMYSRRINSTYTNDDNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9M4</accession>
    <name>A0A0N5B9M4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Estradiol 17-beta-dehydrogenase 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9M4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9M4"/>
    <dbReference type="WBParaSite" id="SPAL_0000274000.1">
        <property type="protein sequence ID" value="SPAL_0000274000.1"/>
        <property type="gene ID" value="SPAL_0000274000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000202">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 16C member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF742">
        <property type="entry name" value="PROTEIN DHS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000274000.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36228" checksum="55F318D1E6B721B0" modified="2015-12-09" version="1">MSAYSILSSIFLLDLLTFTIKVFDFIRIFTHFLYYILEGSFRAILPINVLKRKSVKGDIVLITGGGAGIGRLMAKEFGSLGAKIIIWDINETGIKETIDILQKNNIECWSYKVDISKKEQIYETAEKVKSEIGDVDILINNAGIGSGKKIFDCDDNLMELTIAVNLTSHFFTTKAFLPSMLKRNHGHIVSISSLAGRFPIAGLADYCASKFGVIGFSEALSEELLVLKKNNIHVTTVCPFYMNTKMFEGVVSYSPLILPILDSSYVVERILEAVLTNTEHLYLPKISYLGNALYSILPIKASRIAGDYLGINASMEDFKNRKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9T0</accession>
    <name>A0A0N5B9T0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rav1p_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B9T0"/>
    <dbReference type="WBParaSite" id="SPAL_0000280000.1">
        <property type="protein sequence ID" value="SPAL_0000280000.1"/>
        <property type="gene ID" value="SPAL_0000280000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000280000.1"/>
        </source>
    </evidence>
    <sequence length="1466" mass="171205" checksum="6199BFB69080CD18" modified="2015-12-09" version="1">MEICDIYHGAIRNSTKCCGIGCVNNLWFITCCLNGNVVIFDRNINKIQNIFFSLNFKYEEISNIVCCEETGKIFISGRNVFVIFVPIYNLHDNEIKYYKWEKLDEIVLDVEVNTGAWYHNGTKLIVSAGNFLNIYEINLYNNNLNNENIQELVLNKIWEYSVSYPITIISASNDSMFFATSGSNDTKVVIWYQMVSYSSQTMDKKLTFDFTILNHPTSVVGFEWRKIPKEIFRYEIENCIITFCKDGVARVWKENILNEELYVDHDLEHISDILYGSTRTEEKQQKRQNYFKKMKEKIMAKKHSHSITTTNNNNTKKCEKLKSPDKGTLNIGVFDLPVKMKTVFFYIVSSIVQENISGYIENFGNNAEVFTPRWLNNKSLAFMKNLKKTMTTLNFNEVEEEEDEEIDNKSECESIITIDLEKLYNNWKETSDGLFYINENNGTLTIWNLFNLDSSFKSCDTKLISSTQNVLSPCRLHSKISYAVFIPYDKFTSHSPEITDTNENIEKHTFDMQDVNSTLIIIYKDGRIDASKANIHCQSNLTFLESINYDTFLDGAKYNIENITSYLDFCLTVGSKKSTNKGHYQLEIILWKIVNPNEIKKKCKLEDLTKFYLNVNEYYNKITWLHSGNESNPSFPLTFSMCYDKKLHIYQIYENNTHANKGESRTNNITIKSAFSVDIIKYTIDNIYCLYFTTPGEVFKKNHSEVNYLFIIGNCESLKIPKIILWEYDEKNLNVNLVSVEYFDEKGTSNVFIIPRDKSIKGMMYEYNDYPKICLQTTNNSLNFYNITKECNISKNNGMTFNGPHHHITPAIYDGKMALLIKYNNELILNIYECQNLDATVWNKESSHVIQLTNDINTKDIFISWLLGTEKVYYLCIQICQEVQIFSLSLHNKLFLVCRFFLDDKSGDSLLMEWLENNKFLLGNGNTFKLYSLDEETINILKNKNIQYHPNFLIYLIETNNYDIVNSILKNIFNQVKRYSKYSKNNNITKSVYIEPIPENEIEKVIALRNEQITLDEYIERKKIEEMENNKNKTFDNSSNLFNESSSNLFDSRLSFDDKLSIESEDFNIDMDSDDEVDNEEMVEEDDIGNTNGTYAHGDDELSEDDCKILTDVLKKIELTGLNKDEMYQLISIIEGVTKYYQIKHNIAYDNCSKKYYTFFQIFTSLKKMNNSKINPFPSSTIIWAFHSTSENELFENVLMEVNDNVCWDNLVNYGIGWWLKHPDNLKTCFEKLAQHAYLKKNNPMDAAVYYMVLRKKNIIATLFRKQHDVARSNFFLQSYENEKDRVFAMRNAFNCISKGEYLYAVAIFLCCNDIENALKVVMERLSDIQLGIMIVKTYISNVFEQDKYIENIILKYVLNLTRQKIDKWKEDVGEGLIDIDDGSIAFVEGAHDDPFIRSMAFYMIKEYYLSSITLLHHENYTQENSKTDVNCLPSQLPTLFILYKYLKGNPYVLRQKKILNKNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Y6</accession>
    <name>A0A0N5B9Y6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MED19</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Y6"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0000285500.1">
        <property type="protein sequence ID" value="SPAL_0000285500.1"/>
        <property type="gene ID" value="SPAL_0000285500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000285500.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33790" checksum="B526A6E5A709FB66" modified="2015-12-09" version="1">MEVDEIQPKNPVTIASINETVPTQLTENTLLTTNIDDSNNVSKYNESKKIELAKKLREENKKVGDKFPGFYGVMKKPPNTQKLLGSDDILSIYNLRECFNKVCGKVNEGDSIYSILDEVIGPLENETYKSDSSSLRKLIERPPIVDKEIINFTDQMLKFYDLQPGALDKKYQLEGNAKEIASRYAMECSVNGAKDKSGTNGSHDGVPPINFEMYEKLDSGVRLKKKNRTKEEKEERARRKAERKEKRRLEAEKERFEELNMIKKAKKEEKYIESEKSFTIQTEQEDNEEEITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA95</accession>
    <name>A0A0N5BA95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA95"/>
    <dbReference type="STRING" id="174720.A0A0N5BA95"/>
    <dbReference type="WBParaSite" id="SPAL_0000296500.1">
        <property type="protein sequence ID" value="SPAL_0000296500.1"/>
        <property type="gene ID" value="SPAL_0000296500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000296500.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52130" checksum="1B0B8DC540937484" modified="2015-12-09" version="1">MPSTEHILDIQELPYLTDKESELLQNIFIGTLLVVLILFCVIGNLMVILAILLERDLRSRPQYYLIFSLAVADLFVGLFVTPLGAWITVAGGWNFGEALCDFWTSVDVLLCTASILHLVAIALDRYWSITDIYYVQNRTPKRITCMLIIIWFVSLLISVAPIFGWKDAMSTSRVLEEHVCLISQEISYQVFSTASAFYIPLIAIICIYFRIMKAAKKRFKRERDRKTVIRHGGNSLHTSMESNKFLKNDNKIDDKIVNKKECLPTIPVIIKEDNSEVSMSKKSESNSSNEEDKSMVKISHLIESDEVNESFTKNRGTSRQSLPVIRTYIKPKNKEPKTSLEGMNSGKFKFPKKIKRKRRSKEMNTESRRERKAWRTLAIITGTFLVCWTPFFLVSLYRPICGCKIPDIIEGITLWLGYLNSAINPIIYTVFSLDFRLAFQRILKRLCFIRGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBC1</accession>
    <name>A0A0N5BBC1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase-associated protein LEO1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBC1"/>
    <dbReference type="STRING" id="174720.A0A0N5BBC1"/>
    <dbReference type="WBParaSite" id="SPAL_0000332900.1">
        <property type="protein sequence ID" value="SPAL_0000332900.1"/>
        <property type="gene ID" value="SPAL_0000332900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000332900.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46853" checksum="C9BDB174EA5ACB45" modified="2015-12-09" version="1">MSNILDSDDERNPGPAFGPVSSDSSDDEVSPQKYRSPSEGSSSSSDSSSEDGPHNKSENHRQLNSSDEEDEEDLLRQNEEKKPPVQEGQKHAMPDLSSSSDDNSDGEDNGPPVVNNRPTGIILHPDSDEDKSEDDFHGKKKEAETISVFRPHTTISNTKISLLKLPQYVKIDAKPFHKDYFDDRDFVGNDGVIAKISTENVIRWKYENGDSSGRKISNAKIVKWSDGSTSLRIGKKFFDVVTQKESGTSHCFMRLSSYLFGQAPFKEKVTFRTLEKNIPVISRAKGRNRPQTVKILQEDEIRENPEVEQARIRKLEEEKLRAAQRRENQQRRIREKPRYTGLTSKFLERNGESLNAIKNRYAQGNYSSSDSGSDDDYYGGTRKIESDDEEEESSHKNKKDLKKKKVVIEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBC8</accession>
    <name>A0A0N5BBC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBC8"/>
    <dbReference type="STRING" id="174720.A0A0N5BBC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000333600.1">
        <property type="protein sequence ID" value="SPAL_0000333600.1"/>
        <property type="gene ID" value="SPAL_0000333600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000333600.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28765" checksum="50C69053866E8D9A" modified="2015-12-09" version="1">MVTINYEPLHHAERRGIRHGGLSQAKLFFLLCIICAFGIVLYSYFNLSSDIVTMKEIIESKNAHIQKAVNQIEDLHIELENIKAKVESLNKEKDSLTNDIRNCKLSSDNERRTLLGDVAKEKDQMKAQLNEEKDKNVKLNEEIEKLKKDIEEKVCSADNKKNESDKNVEQGVAPPVGQEPVVKNAKGPLQIPDIEDSLGGMDGKEKLNPGAGEALVPKDNEEINIPEPNGNEAAPGPGIAIPNQENEGFIANDNPPVKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCD3</accession>
    <name>A0A0N5BCD3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCD3"/>
    <dbReference type="WBParaSite" id="SPAL_0000368200.1">
        <property type="protein sequence ID" value="SPAL_0000368200.1"/>
        <property type="gene ID" value="SPAL_0000368200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000368200.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29451" checksum="F271E79B989DF2BF" modified="2015-12-09" version="1">MFYPPMAEPLWDGFNNTIFVIIYFPCRFCLFQSTYGTFVLSVNRFVSVMFPFQDYHNNRKFLMVFLPFYILLPLAFTWFIIPSTIFLFPIGELFSDNYKISIVSYKRPKFYNGPSVSTSLVPYLLTMGTIQLVLNFITSIKLLLHRLKKNYAKNSNSNTKQEHKLVIFTLITYLFQVCFIVLNKLIEITMYDEDETLSNLLVNVGVKLVILQMAGTNIGLILMSKLLRDKMVDEIRNRKRTTIIIKISSHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCS0</accession>
    <name>A0A0N5BCS0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCS0"/>
    <dbReference type="STRING" id="174720.A0A0N5BCS0"/>
    <dbReference type="WBParaSite" id="SPAL_0000381500.1">
        <property type="protein sequence ID" value="SPAL_0000381500.1"/>
        <property type="gene ID" value="SPAL_0000381500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894366" evidence="3">
        <location>
            <begin position="22"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000381500.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="79874" checksum="2A0C30CA9EBD84AA" modified="2015-12-09" version="1">MAFINKFIFFCLTLLFNSCYAYPNDGLKLEKNDSDIDTIQSIEALSNQIIINTSKVGPIDILKVIIDVYDLESKKLLFSNSYSGILLLISRGRYVINFLKPYHWYGIVYQVFQTSTQESKYHIEKIMVKTINDKAKTSSNKGGPIILDLKSERSKVEETHLVVFSLKWNELTTDRNGIDYAKANITLECNKSLKNKEITLNKDEIGKNIEIKLDNDFGIHEENNGSHKLIAVVKPKYCHKLCWKGMVYSNVMNHIFEREISYYCETFNPIYTQTEVRDYVSYNISDDGKLIIFTTQPNDIPTTEEKDDIINVKAIQVAHLDVGDENSTEVMGNEENLIDNEEVRNSTIEKEFIVTGKDGNNVSQFEIVDLEENSYYAVSYDYKKTQPIPYHDEQYFVIQIPDENSTKPSFLPVIVNVSLPSDDEDNSKKDDYLKPKINFYISKEFERHRILVEIEPLINESNNFLPITSSTNDTVFWLNQQSNNHSFNVPDSVMKYLCGVCKLNVIMCNTYDKSQNSRRFRRNEENVKDYGIQGTQVRYNESISNMLSGRESHLMDMAFNETTSKSYENKKNSDFTSSLTTTPSYDETDEKDDDDDNKEPSSNAKFNNLTMEEDGEVLFSEGNGKCSQLQLCYKLHIYLNSKMYDMGKECHNLTKLILTNGKNNMYSTNLMFLFYPFYIICYYYFVERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCX3</accession>
    <name>A0A0N5BCX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCX3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCX3"/>
    <dbReference type="WBParaSite" id="SPAL_0000386700.1">
        <property type="protein sequence ID" value="SPAL_0000386700.1"/>
        <property type="gene ID" value="SPAL_0000386700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000386700.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18944" checksum="7E655E8EA6E44E66" modified="2015-12-09" version="1">MDIAKRTSFGAIIVSTRELVSHIDEQATKLCNGSKYICFKLYGEINSATLREDIDKGADIFVTTPERFYEVIDKGYLKIDNLRYAIFEEFDRLLSDLDIEKTIDILNQIRSFSLNSRKNLIICKELSTELQKNFERIRRKNLFITRNNKKNVFGRNILHTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDA7</accession>
    <name>A0A0N5BDA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000399433.1">
        <property type="protein sequence ID" value="SPAL_0000399433.1"/>
        <property type="gene ID" value="SPAL_0000399433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000399433.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46173" checksum="DDF6D2560FF608FC" modified="2015-12-09" version="1">MGIRIIVTKDNNELYLELNIFYNIVILILGILALFLNGIYCYVIFKEKLWTQSIQYVLNMFISFSGILLGLRHIVVSIVNLTMFDSAIFSYDVPLCKVKSSFDVLILYFFETSFGLRTTFFTILIGLPILYKNYVENVRNNKYIAITITSFSLIYPHETSYNPFLCKVRSSSEIFLLYFFESTFGTRVTIFVIMLNYPVLYRNTIDSNKKGKFVNIPIIIVAILATAFFTFDSLSIKAYGFCSFYSSFGPTYEKFFIALIGAVVILTVPVVYLGSTAIKKFKTEGKYKNSVIQLLNYEITVFLICWFLPNMCIFVCYFIRIKSDQMGMLYDISSLTLTISGIVEFPFTLWKNRDVKICFYKIFGAKTTVIIGGGIEMKNFKIAKSIPKHPTCNKLFNVKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG20</accession>
    <name>A0A0N5BG20_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG20"/>
    <dbReference type="WBParaSite" id="SPAL_0000492800.1">
        <property type="protein sequence ID" value="SPAL_0000492800.1"/>
        <property type="gene ID" value="SPAL_0000492800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF875">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733403" description="Metalloendopeptidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="47"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000492800.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45437" checksum="4F63F5572E6E46EB" modified="2015-12-09" version="1">MNPFIKLFLFSFCIYESFFSFTNNIFKNEGTLKADDNSESYETRIKRSIINNMQFKWTSPIPYFCRFNVNKTLIQEALAILEKETCLKFNETLDFANGFLRYANGTNRCFSSLGKVSNNDLHNVVVGRDCSDVIGVLHETLHALGVIHEMGRHDRDSYIDVKYENIKPSSQFNFVRYDLTEASSYNLKYDFGSVMHYNRYITTKNNQETMVPKGKYKSYLKTIGQKTRFGFNDAKQLNIYYCSDKCPDSKLKCKMGGYPHPNDCRFCKCPEFYTGRLCNKLLPSHKQCGSTRFLKTNEIDKRLVVSGIKTCYFQIAAPRGRKVRLNIEETDLLDSFVCHPDQGLEIKFLADKSVSGAVLCGKNSGEVIISENNVVVMKYVGLTSNSTIKIQYRDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG30</accession>
    <name>A0A0N5BG30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG30"/>
    <dbReference type="WBParaSite" id="SPAL_0000493800.1">
        <property type="protein sequence ID" value="SPAL_0000493800.1"/>
        <property type="gene ID" value="SPAL_0000493800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894307" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000493800.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="14352" checksum="7F395346F7AC1B1B" modified="2015-12-09" version="1">MKFLFNCFIFLVLLPLTSSGYFPGDERFEQMEREKEQQRLINRGRCYLEFQKVYEDYDIVDVVEIEEHHHRDYYFTDFRYKIHKKKSQDKKKCVKLRSRIEQGSKVGSCDFLKSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHG1</accession>
    <name>A0A0N5BHG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHG1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000540100.1">
        <property type="protein sequence ID" value="SPAL_0000540100.1"/>
        <property type="gene ID" value="SPAL_0000540100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF141">
        <property type="entry name" value="TRYPSIN-LIKE PROTEASE TRY-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="583"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000540100.1"/>
        </source>
    </evidence>
    <sequence length="854" mass="99159" checksum="E4E2CDBF7459029E" modified="2015-12-09" version="1">MVDSEIPWMARIVNHLKTVICNGILVTQLHVLTNFGCLKDIESLISQQSEYNQLYDRYQVRIGEHSSEDVCDTNSDGILNCSSKVLLRYINVLHLRHPVMANDLKYGVIELNRPVTTIPHACIYQYQMDFLGLEEKTEVENVISLMWGVDHDNNFDNFELRAYFYKETFDYKNKRFANSFGCKIREDYLMVIEQMQSLLWKSELKGAPLLRKIKDNQFGVYGIGEDTCVKNFNKEIKHVQELFFVTFESAQYFLFHSLNEVNHSEENLGNKFLNFSNFYDEDTCGRIRKKDESPYNSDFFQNEVSHPWILSIAKGDHACMGTLISKMHVITSYECIYNILKVETKRLFEDRLKGLLVIKSKKYCTFWTTKKEIYVFGKSSTYDCDNFDIQYREIYQIFPTTFTDDQKQSAILVLKEPFHDTPHICLDDKVDPLKYSRIVKKYLVYYDTTLSDDSNEIIYLAEYILTQSSEIKLGFHGHNISVTDDNFKYICGKSAGSNIFFKTSNGKHYLYETQKGFGACGDKTKSFNYSVDNDFIKFVFKKLPMIKYDTSPFVYNLKKLQYYDYENCGRSSINLEVIYEFLISGGHDINDNKAIPWAVQIITKQNSCSGVLVSHRHVITAAHCILNIDNLSFWYYDKNIAYDAKIVIGNFCTENINVDGKCNNKEQSQKRTINRLLYNFKSGFRRNRNDIVVIELNAPVIDITHICLPFLHDNYKFDKSKTLVTFGYGITKRGRGIKRLKLHNRLKRFVYSDPASVRNCTPPIVPVNSTEYLCVDANIHLGLCPGDSGGGLIQRTSDDRYILIGINSRTLSCVFSESVDSNSERANLFLRVEEYKDEILNFMHETKTYYSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI92</accession>
    <name>A0A0N5BI92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI92"/>
    <dbReference type="WBParaSite" id="SPAL_0000567600.1">
        <property type="protein sequence ID" value="SPAL_0000567600.1"/>
        <property type="gene ID" value="SPAL_0000567600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000567600.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="63549" checksum="AFAEDF2503F2F488" modified="2015-12-09" version="1">MDNSEESNVLSKLLQINLVRKAIINHIPSFSDISNLVNAYQFIINDLEREKIERSMFPYFDLQLVRVGHVNRFEASSGVPGIYNLEFSNNGRLECVLNKSRTFFGEMLPISNCVKYSIGLSIEKLEDDDRMDFVEVLAEKLNLNCNLRKNIKSLEFDLDYPDDMGYIILDALSYIEHDNITRISLPVECFTSPSDKYNMINENIFNGFPNLTKIILTKGESNCFYCLFYCKNIFERFVQQMSTAKIPTIFFKRLTGYDIIDINEINDIINIIKKYNIKVKLGVYINCPSCFVQYRNSTYTMETFSPIKKYITDACGWIRGYTELLHKIGILETFENLSELHLKFKLDDVIFNFKNSNDQKPGDWGLRKLNNLKNVKLGYEKDLDVRNSDILNLFYQLFEFTCSMMPRSVEVLQLKNVPDMNDVTAKMITKYMPNIKLLKIKCLFYKESDGLDNFSKLESLISYNYCPIIIPRTLKLLALAVDFVYDKRAVRSDELIFTDNLIRSHYEKFTKRIRDNKDNYILFNGIHRWHLYKCILQEYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK40</accession>
    <name>A0A0N5BK40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK40"/>
    <dbReference type="WBParaSite" id="SPAL_0000630500.1">
        <property type="protein sequence ID" value="SPAL_0000630500.1"/>
        <property type="gene ID" value="SPAL_0000630500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000630500.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="50793" checksum="3117DAE48E25E7FF" modified="2015-12-09" version="1">MLYTIFVKYRRIFHIVLGIFLIYTVKKVSSDSYKLRKCENAMKKTLENILQRSDDKNSLLLTPFHETIAKFKNDSEAYQRTMWGCFSIFRFEKCLSILEDSHQKNIKLASIKHWKEICNYARERKEDFLEFLNCERRHIFKTKTHCAMPSKEHNQTTLEIFCENLYEYNRCYRSIDKRCSESALEISYILDEAVIESYTNVVKLAAYIIQIPNTCNWIMKPNIREISKNKYKESRESKKQEKDAYALSNQKNTTYLNYSLKKEDIENIILNTSDNNLVDKHNHRHHHKAKNSKLLITTSTLKTDIHNDEDNYEHVSIYKINDTYNYENEIFTDIYEEDDNISTTNDPIALNNEVVETTTESNDDIFDNTFSSKLNSSHMIVKIENSSIINPHSSISGLVKNKSNYIYIGYQYILLITILFILFFPLKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLH2</accession>
    <name>A0A0N5BLH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000676933.1">
        <property type="protein sequence ID" value="SPAL_0000676933.1"/>
        <property type="gene ID" value="SPAL_0000676933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000676933.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9090" checksum="FAFD63EA990E64DA" modified="2015-12-09" version="1">MLNIRCVSSLRKLQMVHIIGRFVCNGNPVNNVMVTLFHRNRFGGPSLLGKLPCDENGLFDLQGNKKLFLGMGKYLTKVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM85</accession>
    <name>A0A0N5BM85_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BM85"/>
    <dbReference type="WBParaSite" id="SPAL_0000702600.1">
        <property type="protein sequence ID" value="SPAL_0000702600.1"/>
        <property type="gene ID" value="SPAL_0000702600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="10">
        <location>
            <begin position="808"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000702600.1"/>
        </source>
    </evidence>
    <sequence length="1356" mass="157204" checksum="EC7152CB88A09E3E" modified="2015-12-09" version="1">MSENSNSDDNGYDKKDDSFEITIPEFPNDSSDDPSFSDNENLQVKKKLEKGEKLPNLPHVAEQHAPGTMPLAVLLQFVCQKINQELFSLTEIVCNTSDIGRKVALVQFSYTAKNLLSKLLAIVKWFRYFKRYRLCIPIQNFLDQQLQHYRETADTLCGIARGELTYARMPPYNIDSAIDVVCGVYARLPQSIKKRFIPEPELSTQEIANILARINLAIKTRLSFMAQSFPTQIKNIIVHNGTVTFVVPGEFEITLTLPGETLDVKWRLLRVRILVQDYEFGDGKELVHHLQLKKLHKFCQKLLDTSKKPIISVFNFLHDFCVTLQFDLIFGEILQLTQGTYRNKVFINTCNVQKRYISLKYWVKKRTKKTPSSYNQIVFYISNKSKDGGVVVEFRPSNSFPLDVYKEFEGKPSVHNILRSAIEYNIYRKLTILKEQLEKCRPKSSVKLTGDLLPKVTYYLLSKDFDGENDELSFGVNFSTGEYMYVGDNLKESLLLKAMVVGLNNNIEHKKLERCLDGIRTEFIMKKYVKSVNMLNVKLVPEKILPSISRKYAFFEHSVKLYFQIIKEPQHYVVLTFTDPKRKGLWVNFFLISLNEGKSTVVKLNPSEFYTPSKINTPDERYYLGEIGNSIKYSKKGCSLQYTPHEVGAIINGIENKVNMIAVCDEFLKKNVTLGFVKNDCISNSPYLEIPNISKLIGSDNSKFFDNMKRIILRNDARFKHIWPLEYLLINTPIVEDFYKRDINGQNLVRLTGKKRCFHDIRSSGIVLPIVSFYEVITSALVDKMKTFSMLYKHVFEFAHSYYRYYNNYCRIKLYSYHKLIIAYGEDRDQLVFLTYKASKDSFLLSFGQDSKQNFVNGDTNDSSDQEPSTLWNPHNLVANFLSEKSGRKNFLPELVDYLINTTRPLTSLCKGIRHKIICSSALTQILIGESMYSEEFDIQLVPHSEYIFKIICGHMIIEVFMYAKNYVYLKDSSYEKARLYGFKELLKGFGGNIIDMSAIVNDETSIEKGARSLPASNREEMEEVMRNPLSLPSSMSVDGKGNDNYTPMDDDTRSKEKYNEEYFSSSRDLIKMSHDSFDKLLYQDPKIKPISDLRNYLYSLRSFERITTILVHNYGKPILGGGGLMIHNVNVAHYMVRATFSAAKRSDGHVPCNINFIVFIEPDTFKIKLKLEYTGAFRPTDDEIKIAEEYFEYVLRYTESPQMVYSFMNLIRMIFPRFFSCITNLMSLQLNPDPLNFYTMNFEFVNLLHRKEDSMPKYVSQILINEHSGRILIPITIRPQNIYPNYKNNEPNSKIKLDFVWEAANNEVYIHNVNDDFFKMINQRIIQFNSTIKESMECTLEACIRYILKNEIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM87</accession>
    <name>A0A0N5BM87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GRASP55_65 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GORASP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM87"/>
    <dbReference type="STRING" id="174720.A0A0N5BM87"/>
    <dbReference type="WBParaSite" id="SPAL_0000702800.1">
        <property type="protein sequence ID" value="SPAL_0000702800.1"/>
        <property type="gene ID" value="SPAL_0000702800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000056">
        <property type="entry name" value="Golgi reassembly-stacking protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="11">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000702800.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="64624" checksum="5F3482A9B002A266" modified="2015-12-09" version="1">MGNSESNFIPGGGSEGYHVLRVQPNSPGEAAGLEPFFDFIVAIGNTRLDKDNDTLKRVLEDHIERPLELTVYNSKTQTVRQTQITPSNVWGGQGKLGVSIRFCSFEGANENVWHVISVKPNSPALQAGLISDTDYILGAESVLNQADDLIALVQANEGKPVKLYVYNVEHDNVREVTLTPNSNWGGEGCLGCDIGFGYLHRIPTYFDRSKPISTGGGVEMPADNTPNTAEYFKKDRETNNQHDHSECGGHGHSHDGHSHSHDGHSHNFTVPESKPIDEQPVSIFPSIPPPKPIPQTFEPPTNVPINPYQNTYGAPPTFPTATVHPTPIVGGTQDDKSQPLPEIENLNINERNVPNFSNKVETSNEESTQEPRLDLQHGQNISHVTPVQQSETPSYPLASVQPMPQQRQEAHVTPKQQNIPLVAPLPREGSNFNQHSYHQSQDGQQNNYFMPSPPSEGAPYYPPNVSAVPPMPVSNSPYNFQHSQPPSVSSASNPYQTPTQYYNNQPTCYQNPYYPPTTNYGQTAPPLVPPMFADQHMGITTPPINNGMNYNIGYTQPQINFPMPPLSSMGINELVPPPTNMQSEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNW2</accession>
    <name>A0A0N5BNW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-splicing factor ISY1-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNW2"/>
    <dbReference type="STRING" id="174720.A0A0N5BNW2"/>
    <dbReference type="WBParaSite" id="SPAL_0000759000.1">
        <property type="protein sequence ID" value="SPAL_0000759000.1"/>
        <property type="gene ID" value="SPAL_0000759000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000759000.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30761" checksum="ADBA6AF70C1DB1D0" modified="2015-12-09" version="1">MARNSEKAQTTLARWLKFKELEERGPISKRPVNVKDCTNVQDAERFLGEVSREITKNVTLIQNPGLGEGRIRDLNDEINKLIKIKEAWEKRIRDLGGPDHRRLREKIESSGAGLASNRGYKYFGAAKDLPGVRELFAKEADNIQRKDSKKDVYISNPGAAYFGLLDDDNEKLVELEKIEEEVAKQKIEEEWEVRKSVMNKAHEFFKNAFFIDGDYSSVIEEMETEDFVDDISDNTKIKRFVVPNQEEMATLLVEAKRKQLMEKLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ16</accession>
    <name>A0A0N5BQ16_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ16"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ16"/>
    <dbReference type="WBParaSite" id="SPAL_0000799000.1">
        <property type="protein sequence ID" value="SPAL_0000799000.1"/>
        <property type="gene ID" value="SPAL_0000799000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894683" evidence="5">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="6">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="6">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="6">
        <location>
            <begin position="243"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000799000.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36915" checksum="D605DD7E154D1CE3" modified="2015-12-09" version="1">MIFKLHYPLFILFLVAFIEGAEKKPKCGANMVAKKCRACSNTCSFTRSLPPKPLKKCYEKKDCEKNKYYACVCKKGYYLNDKDKCVRKDKCYSKPKTTKKPTTTTGKCPKNEIWASCRSACEPNCLDNIKEPKPCPRICKPAGCQCKKDFVRDDSTNTCVKRKQCTKTSTLFPETTPSCPKNEHFDECGTACPITCNNYYNQPKVCTMQCVIGCVCNEGYIRDKQTNQCVLPIHCSRNTTYECPENEHFDECSTDCPITCSNHKNPPKVCNKMCRVGCVCDRDYVRDEASDKCVKRSECPTRTTVEPETTPVCPANMVYTNCKSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQZ6</accession>
    <name>A0A0N5BQZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000830300.1">
        <property type="protein sequence ID" value="SPAL_0000830300.1"/>
        <property type="gene ID" value="SPAL_0000830300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895005" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000830300.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8858" checksum="2424F6C90CDAC567" modified="2015-12-09" version="1">MKFSYLLLTLCLVILQLHISTIECNGLKSIGEAQEGAMETHPVFKRSSLQKLGRRFRIGPRRSIMKERRIPLFKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRB8</accession>
    <name>A0A0N5BRB8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BRB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000841900.1">
        <property type="protein sequence ID" value="SPAL_0000841900.1"/>
        <property type="gene ID" value="SPAL_0000841900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000841900.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16339" checksum="F8A7BD7522CA9ACC" modified="2015-12-09" version="1">MELPNPYLVGAVSLFESLGKRIIVQLRDGKTLIGVLSSIDQFVNIVLDDAVERIFVDKYYGDIPRGVYLIRGENVILVAEVDEKMKVDLKEVDPATILTMHDEKMEEKQKEEERRAKLLGERGIIVNERQIRGNEMMLENMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRS7</accession>
    <name>A0A0N5BRS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000857200.1">
        <property type="protein sequence ID" value="SPAL_0000857200.1"/>
        <property type="gene ID" value="SPAL_0000857200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000857200.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13906" checksum="CFB4E480550C2BEC" modified="2015-12-09" version="1">MSYPVVVNNGNAKKLAEQIERNKDISNKLSPFAKYTKLLNSNLKKKQQPMKRKFSIMYSSLESNKKNFWVDKNYGEKNYQNNIIVSNTFPQIHNHNFMMCQSPANFIPPFKIPHNITPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSE0</accession>
    <name>A0A0N5BSE0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSE0"/>
    <dbReference type="WBParaSite" id="SPAL_0000878300.1">
        <property type="protein sequence ID" value="SPAL_0000878300.1"/>
        <property type="gene ID" value="SPAL_0000878300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894788" evidence="2">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000878300.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9371" checksum="66E9CAB1EF61DFD6" modified="2015-12-09" version="1">MKIFTVAFYFAILVGATFSNPQMPNAVSSHLKPVDKMLHAIPIMDKVCKQVSEDVIEEVCKDLNEAEKSVDPKEICSKLKICSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSE7</accession>
    <name>A0A0N5BSE7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000879000.1">
        <property type="protein sequence ID" value="SPAL_0000879000.1"/>
        <property type="gene ID" value="SPAL_0000879000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000879000.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36789" checksum="89DB1F8FBB5CEAA2" modified="2015-12-09" version="1">XDVRLIIDFESGDNDSLANALKMLNYGKTINLNIQMDYDLDWNKYLKENNYNFTEEMINIKDEIKFLMVSINEINDFKVLKILLNSLENLQHIKIFVETSLLKVILDEYKSLDDAKSYLKEFFNYRSCLKHLTSARISFGSYDTSPENPNSENIKHLYNFMMDCMISILPSSISKLLYLMEAEHMTLEFFEKIGILFPSLTTISFLLCYNIPENALYKIPSLRNVVFNGERKVNIPPWVETVMFLYFDIDFYYPDDIVSDNKNNEHYFTLMDNKFNISLRCLKENDIYYIAFLKNFEKWKELDKLMSICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSG2</accession>
    <name>A0A0N5BSG2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="174720.A0A0N5BSG2"/>
    <dbReference type="WBParaSite" id="SPAL_0000880500.1">
        <property type="protein sequence ID" value="SPAL_0000880500.1"/>
        <property type="gene ID" value="SPAL_0000880500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
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    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
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        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
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        <property type="entry name" value="ArfGAP_dom"/>
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    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="408"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="353"/>
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    </feature>
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            <end position="384"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000880500.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45086" checksum="68ECC3AF14027448" modified="2015-12-09" version="1">MASPRTRGILKELRPLNENNTCFECGAPNPQWVSVSYGIWICLDCSGKHRGLGVHLSFVRSVTMDKWKDRELMKMKVGGNTKAKEFFMSQPDYKNNWSIQEKYNSKAAAYLRDKINTEADGDEWDINTSSAKNYVPSTLGIIASKSSTTTLNSTRSSSSLNNTQSDSNEYFDSYNNSDFNRSNKYQGFGNTIDSGKKEDDLLAGAMNSLSLGWGFLTKAATQGAEMAKEVTAQVSAKASELSSKHNEGDLLSGIGSSFATLTNKATEYGSKGFEGITNIVKSTSFQNFTGTIKSQYEDLTTPDKSKNFGTEIGKDSLNYNSSDFSSYNDNIQYNEEPTNDGEKPRKVTKEQNKPKKKNKTSDNLIDLDFDSVTSFGSSESSSKSKATKPVDIPKVKSPEDDVWEMLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTM2</accession>
    <name>A0A0N5BTM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BTM2"/>
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        <property type="protein sequence ID" value="SPAL_0000920300.2"/>
        <property type="gene ID" value="SPAL_0000920300"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="24"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="FAT atypical cadherin 1"/>
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    </dbReference>
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        <property type="entry name" value="FAT atypical cadherin 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="28"/>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
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    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
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        <property type="match status" value="25"/>
    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
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        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4052"/>
            <end position="4072"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="56"/>
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        </location>
    </feature>
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            <begin position="175"/>
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        </location>
    </feature>
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        <location>
            <begin position="411"/>
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        <location>
            <begin position="646"/>
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        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="747"/>
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        </location>
    </feature>
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        <location>
            <begin position="851"/>
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        </location>
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    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="960"/>
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        </location>
    </feature>
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        <location>
            <begin position="1064"/>
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        <location>
            <begin position="1188"/>
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        </location>
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        <location>
            <begin position="1379"/>
            <end position="1490"/>
        </location>
    </feature>
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        <location>
            <begin position="1606"/>
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        </location>
    </feature>
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        <location>
            <begin position="1730"/>
            <end position="1838"/>
        </location>
    </feature>
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        <location>
            <begin position="1870"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="1941"/>
            <end position="2044"/>
        </location>
    </feature>
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        <location>
            <begin position="2043"/>
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        </location>
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        <location>
            <begin position="2134"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="3411"/>
            <end position="3509"/>
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    </feature>
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            <begin position="3662"/>
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        </location>
    </feature>
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        <location>
            <begin position="3717"/>
            <end position="3909"/>
        </location>
    </feature>
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        <location>
            <begin position="3913"/>
            <end position="3954"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="3956"/>
            <end position="3992"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="3996"/>
            <end position="4032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="4130"/>
            <end position="4158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="4279"/>
            <end position="4342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="4136"/>
            <end position="4152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="4313"/>
            <end position="4325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3693"/>
            <end position="3702"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="3882"/>
            <end position="3909"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3944"/>
            <end position="3953"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3982"/>
            <end position="3991"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="4022"/>
            <end position="4031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000920300.2"/>
        </source>
    </evidence>
    <sequence length="4342" mass="489840" checksum="9C49E9ADEAC52867" modified="2015-12-09" version="1">[encoded data, 4342 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTR0</accession>
    <name>A0A0N5BTR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH_Tnp_IS630 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTR0"/>
    <dbReference type="WBParaSite" id="SPAL_0000923700.1">
        <property type="protein sequence ID" value="SPAL_0000923700.1"/>
        <property type="gene ID" value="SPAL_0000923700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000923700.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7707" checksum="9BED0FE76B732AA0" modified="2015-12-09" version="1">MRTSITKERRRHKPAIYNGESRKAVEANLRGTDRELPEDLIVSKLTISRLLKKIKRQGSPTNGYLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTZ8</accession>
    <name>A0A0N5BTZ8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTZ8"/>
    <dbReference type="STRING" id="174720.A0A0N5BTZ8"/>
    <dbReference type="WBParaSite" id="SPAL_0000932300.1">
        <property type="protein sequence ID" value="SPAL_0000932300.1"/>
        <property type="gene ID" value="SPAL_0000932300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="33"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000932300.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36950" checksum="AA0E1297E49A9D97" modified="2015-12-09" version="1">MDKDLEDGLLERIFMFHAIENNARLDGRSNECYRPPEIFLGINENCSGSARCTMGGSDVMVVIKPDIYKITKEPTWEDFIKFYVTCSPVAHPKYDDVGDDNDIDGEEVSATEESIMANALMAMFSSIKDEIDFTNFRISKKHIWTFIVDVVVHADNGAVFDCMAIAVRAAFADVQVPSVISTMIDYGEVGLEIDSNVTFWGCKWDLWPLICTTNKLGFENLVNCNRYEDKYVKSLLMIGLKHDEIKDDEMIDYEEINYDISKHIFYAKLRKEGGLQILSIDDMTDIGVKVVLKMFSEVDRLIRDCLRRKAKETNVVSNRGITYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUT4</accession>
    <name>A0A0N5BUT4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000960200.1">
        <property type="protein sequence ID" value="SPAL_0000960200.1"/>
        <property type="gene ID" value="SPAL_0000960200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000960200.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="76013" checksum="DD0BA12CB81AE906" modified="2015-12-09" version="1">MHFFDQISTRHSRENYLRSFHYFEDPECIEKPVLYNASTYKKPENVDSDSDDASEIVEYIDLNEKLNFYGFSMVDRMHRMLTCNNYLILKNLRINEFSKNNRIQSFFDGKLAREILSQNCDTLFFMLYIDDMSTYARGSPLAKSINIASILLLNLPEYYISSIDAIRFCLFSPAENSKLSCHQEPYDTLISMVKELENTRLYFENNFFRFKLYCVVADNRELQNMYSIKDGYFGSGKTPCRICLLKTDDFSTTYHEKPELLRTEDWNNIFTQKLKNYSPCKTRYVDLCHDVMLGVIPFGMCVIIHKLIKRIKCIDLYGINKALRKINFKNLNLPPQITKIPSDKKNIRWLSFTASQSYNFLLMFPVIMAYLEEDKLVKNINKGEEIHNQIVDCMAELYLLRKIVKILFSHDIGSDDIKTLDMMIGKHLRFMSTETGRLVYKQHLLTHYPNSIIQLGPLTSVSTLRFESGHQPHKLNSLTGKNRVNEPLSIAKKDAYRECKLYASNYNFEKHGRYVPQRNDNVFLMTSTTECKNLPSRSKKIYKDSDYGKGIRLFHVVDFKNNLIEAIEYDLKFEIEGMLFVKLNILGEKKSFPLSSLVSKKSEFYLELFKNTIFFPNENYYKNYSFPNISSYRNEYMSMKKNFFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUV0</accession>
    <name>A0A0N5BUV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000961800.1">
        <property type="protein sequence ID" value="SPAL_0000961800.1"/>
        <property type="gene ID" value="SPAL_0000961800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000961800.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="22437" checksum="CD913CCB32420CEF" modified="2015-12-09" version="1">MEKPSFLNYEKLLKDYSRGMVKKEILYELLYEIYIYENKREELLSYFKSRYNNIYYIFKDLKYRSVCETGFIPDQIIRICTPRGYPSTIIKPQFQTEYYSLEKSKLFIECDPNTCVKNCDKKSHKKWFKINFVEDSESSLKVVEELKDLAKNGQNQTLFLEKMVKIKHYFWTLSVPIFFGGIRTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVN7</accession>
    <name>A0A0N5BVN7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dual oxidase maturation factor 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVN7"/>
    <dbReference type="STRING" id="174720.A0A0N5BVN7"/>
    <dbReference type="WBParaSite" id="SPAL_0000989300.1">
        <property type="protein sequence ID" value="SPAL_0000989300.1"/>
        <property type="gene ID" value="SPAL_0000989300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF1">
        <property type="entry name" value="DOXA1 FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000989300.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49999" checksum="7A73863FCF191B6D" modified="2015-12-09" version="1">MQSWFTAFRNNMAPSSFRAIHMPQGFDIHIFLMVAVFIVPYIAFIIILPGIRKKRLISFIAITYQLAIGCMLAVSIVLPYWNVGAVNVETFIKAHSTDVTPATISVKVGLNLLNVSLNINTPVLHDYVSNNQFDLSSHKAMKVELYKAYKKGLSLPVIKILEYFSQHQEGFDWGYKYRRAGHYTNAFLCISIGFWCLQAIFLCLLPHHYSKAMIISGIFTLLANLTYAVVSPSNFAIPFRGENGALSLLIFRYGACFYISLICGLLQVAIGTGLLILQILRVYVILTVMSSKTMDANVGPSCKHGGIRRQITIVRGRIDDDRIRCSTYISNQIRARNCAQLNVSTGSKITPPVTLISEKERSFPQSTISTDVSIQEKRKIMDESRNSPYDSRSSLKTTPASSMGSIDNVIHRSISQVVLQRPSQSDDVTNDQFIVDDNRICTTPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW22</accession>
    <name>A0A0N5BW22_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW22"/>
    <dbReference type="STRING" id="174720.A0A0N5BW22"/>
    <dbReference type="WBParaSite" id="SPAL_0001002700.1">
        <property type="protein sequence ID" value="SPAL_0001002700.1"/>
        <property type="gene ID" value="SPAL_0001002700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001002700.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15432" checksum="54C8FA86BDF6E7B5" modified="2015-12-09" version="1">MVLPQSLLRSAQNHPMLIELKNGETYNGHLATCDSWMNIHLKDAICTSKDGDKFVKYPEVLIRGSTVKYIRIPEEVVDLVKKEAEEARKQQKDNKKFKKQWNNRGGGHNQRGGIQKSSGNQRNNRGGRGNFQNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWI2</accession>
    <name>A0A0N5BWI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWI2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWI2"/>
    <dbReference type="WBParaSite" id="SPAL_0001017700.1">
        <property type="protein sequence ID" value="SPAL_0001017700.1"/>
        <property type="gene ID" value="SPAL_0001017700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000021">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="14">
        <location>
            <begin position="507"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11 12">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11 12">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11 12">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001017700.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="83103" checksum="C3BE17CFEB0DAA82" modified="2015-12-09" version="1">MSNIKNFLHIKKINEERRLRKELIEVLKEFHKKYSYKNNVHSINRLDSRVFTKEWVVKVNGGWRNLIKAINDTQYKIVKKIKGFNDIFVLRETNNTVIDNGKNNNRIKRKINSIEDIGKNSNVEWIERQKSYKRFKKDLFQIFNFTNENLHKTEEKSYENKSLPMFIDPLWKNQWQIHQYDEERKNQSIHQFYDMQIMEVWKMGYSGKGIVISILDDGIDYNHEDLKQNYEPLASYDFNDDDNDPLPRMDDFNKHGTKCAGIIAMIANNTKCGVGVAFNAKVGGIRMLDGEVNDRVEAEAITYANQITDIFAASWGPNDDGRTVEGPGYLTQLALKSAVINGRGKKGSILVWASGNGGIHSDNCNCDGYAASIYTISVSGVTQNNNSPWYGEECSSTLVSAYSSGSKSENLISTTDLNNKCATDHSGTSASVPTVAGIIALTLEANNSLTWRDIQHLIVWTAEPSGLIKSSSDGWQKNGAGFLINSRFGFGLINAKRMVKWAKNWTHIPEMVTCSIVFPKFEKRWLTSSKALNIKFNVNGCRGMKNEVNYIEQVQLLVEAKNRYRGNLAIWLESPKGTKTQLLHPRHLDDSTSGFKNWPFTSVQTWGENPNGDWNVFIVDLETEGFVSNLTFVIHGTKEMPKYRENEKQYNLHNIEGYVNKNRENNKLTDSINVLSHGKRFVQMVTENGVDVDNFSAIEQIIALHEELKKFKISKKNQKEIFIEGMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWW9</accession>
    <name>A0A0N5BWW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWW9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWW9"/>
    <dbReference type="WBParaSite" id="SPAL_0001030700.2">
        <property type="protein sequence ID" value="SPAL_0001030700.2"/>
        <property type="gene ID" value="SPAL_0001030700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF14">
        <property type="entry name" value="GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895058" evidence="3">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001030700.2"/>
        </source>
    </evidence>
    <sequence length="192" mass="22204" checksum="4AE1B54E98698427" modified="2015-12-09" version="1">MNKLNTILSSIILFIIFTFTSSQQVNVTIFVESQCPYCTKLMREQLWPFHITRPGIMNLQIVPYGKGQCVFNEKKQLACSCMHGPTECELNRLQNCAISYFPQRHIGLVTCIQGLANLQEAHQRCLSRLSPITQQRLMQCASTQIGETLNYYSMINTHRAQVNLWPTVYVNGRFFDRSYSMEQKICENTSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX84</accession>
    <name>A0A0N5BX84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX84"/>
    <dbReference type="WBParaSite" id="SPAL_0001041750.1">
        <property type="protein sequence ID" value="SPAL_0001041750.1"/>
        <property type="gene ID" value="SPAL_0001041750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001041750.1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7506" checksum="DC78C5266F6EDF48" modified="2015-12-09" version="1">MPTNNPCFIIIDNNMEAGHSLYFHSPSFIKNKNRRLLTENFIFQEPPLNMNEVIKWIKGLVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY33</accession>
    <name>A0A0N5BY33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY33"/>
    <dbReference type="STRING" id="174720.A0A0N5BY33"/>
    <dbReference type="WBParaSite" id="SPAL_0001069400.1">
        <property type="protein sequence ID" value="SPAL_0001069400.1"/>
        <property type="gene ID" value="SPAL_0001069400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001069400.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23738" checksum="2A9972124486DD75" modified="2015-12-09" version="1">MSKKGGRGGSMAQLASALGIQRGDIGTLVNRKREEPKLYTPLARSGAQIEMSNDLQFMVDMKQAVIRNFEASEFYRSESLVSDMDKSYSDKYLEQEKDIFIPYLNRVPIELHPKKTKEELIAARKRKYEIELSSRIANLEAMETQGNGVEKKAKPSGYEDEEEEQKDDDENVYSDDDYLEEDNDYATTYFDNGEAYEAGSDDNLGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYC7</accession>
    <name>A0A0N5BYC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYC7"/>
    <dbReference type="STRING" id="174720.A0A0N5BYC7"/>
    <dbReference type="WBParaSite" id="SPAL_0001078800.1">
        <property type="protein sequence ID" value="SPAL_0001078800.1"/>
        <property type="gene ID" value="SPAL_0001078800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001078800.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18206" checksum="ED8DD451A76A1135" modified="2015-12-09" version="1">MSSGVLVGSDVQNAFQQLSEGKRTLRYIIYKIEDNQIVVETAVPTGDVGSGDDYDDNSKVAYEAFVKDLKERTDGFNDCRYAVFDFKFSCNRPGAGVSKMDKIVFIQLCPDGASIKKKMVYASSASAIKSALGTQKFLQFQVSDESEIAHKELLNKLSEKYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYH9</accession>
    <name>A0A0N5BYH9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYH9"/>
    <dbReference type="WBParaSite" id="SPAL_0001083300.1">
        <property type="protein sequence ID" value="SPAL_0001083300.1"/>
        <property type="gene ID" value="SPAL_0001083300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001083300.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53777" checksum="6F1DAD349B49028A" modified="2015-12-09" version="1">MKFFIQALVIFVYFPLIYGFGGLTRLRIQQETVEKMSKEGKQHFEKFQEAMSTLDKLNNQIHGIDTSNIDEEHMKPGSSPRENPLMYQGDMILGDADTKYLIEEAKLKVEAKKSNKTGPDAEKEIIDKLKKNRAFKKNAMFKWTFPIPYFIDSGVNQNIVDTALKNIEKETCVRFQKTGPFNDKSGLRIFKGSGCYSTVGRSANNKPQDVSIGNGCEVNGIVQHEVCHALGLYHEQARPDRDNYITVDLSAVPQKWQRNYVKNTLDTADTYGIPYDYGSHMQYDKMSFADGFKVVMTAKIPVYTDTMGQTLNMHFNDAKLLNIVYCKDKCKGGIRCDNGAYENPNACGTCKCPFMLGGPTCNEVVKNPPQCGGGSNILKATPQKQTFKANGIKNCVYLINADNGKKIRLTVKGEFKHKRVCQVEEGTTIKFLNDKTINGAAFCNRADNVPITSEGNQVYFNYIGHENSHYLELTYQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYI7</accession>
    <name>A0A0N5BYI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PBPb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYI7"/>
    <dbReference type="STRING" id="174720.A0A0N5BYI7"/>
    <dbReference type="WBParaSite" id="SPAL_0001084100.1">
        <property type="protein sequence ID" value="SPAL_0001084100.1"/>
        <property type="gene ID" value="SPAL_0001084100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040128">
        <property type="entry name" value="T25E4.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22714:SF3">
        <property type="entry name" value="PBPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22714">
        <property type="entry name" value="PROTEIN CBG02446-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001084100.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51400" checksum="C0B2D75641C0B86A" modified="2015-12-09" version="1">MSLRDDMSNYSPHNPDFVFRIGAFSAEPDVFNCFANLPKKPCPKPGAEMEMVQIIMALLKWNWTVIDVVKEYGIDPQFGDPLPNAPMNYTGILGLLQNGIIDMAMPSMKITVSRKQNASVIFSYPFRFFQQIYIIATPTENDYRNFIFATFSTHVWLLIVASLVSVIILEFFILMLEEKNIPLPQKIIDSFTEPISIILRQNVKKHKSIAHFIFQGNLLLMFVVIYVYFQSVMNSRLTAPEKQQLPFTNQKEFLDLLEKGIRFPTYIEDKMPDCSNEENCKRMPQIFKRNPIRIATTFNEIIDQIRKGGIYYADYDVEFIPDVASVWSYKDSLTIIRDPTGIRSYGGFAFHKQNARYRNQFNNALARIMGGINQINLASGYNEKKASSNNVVRPQRMTLSLTKHFEQLFLIFGIGLGISIFIISIEILLDKILLVKRLLVRTFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYU0</accession>
    <name>A0A0N5BYU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SURF6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYU0"/>
    <dbReference type="WBParaSite" id="SPAL_0001093800.1">
        <property type="protein sequence ID" value="SPAL_0001093800.1"/>
        <property type="gene ID" value="SPAL_0001093800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001093800.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="20684" checksum="07761FB098B5E27A" modified="2015-12-09" version="1">MFSVFENKVKCGRNVQAHDVVYKRGDKDFENKEIFKIIRLYDKMRYEKKVKKMTKSELAEFRAKNFYSKKWRDRKTEKERVSKIRWNSKMRTERHRTMTEEDRSEYNRNVRKRKQKKKEVAEKLETLLKDSSEYKQLLKAEKVKKGKKQKIIDNGKEKLKKWLLPWPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZL6</accession>
    <name>A0A0N5BZL6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZL6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZL6"/>
    <dbReference type="WBParaSite" id="SPAL_0001120700.1">
        <property type="protein sequence ID" value="SPAL_0001120700.1"/>
        <property type="gene ID" value="SPAL_0001120700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001120700.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18017" checksum="CDB6B38B6003FB38" modified="2015-12-09" version="1">MIKLKNIRINCFLIIHVVIQRITNNDCILVIKLKPIKVETKILTNTLALNRAIFLRMNTKILVLCVIGSIVAFATAHGFNDYNGEYETEPESVEIGDNEISEEGIQPMGNFGNQQWTGQHWNSNPYNGFYYPTQPSNLNRNWYLPNGFNPHHHGNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C056</accession>
    <name>A0A0N5C056_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C056"/>
    <dbReference type="STRING" id="174720.A0A0N5C056"/>
    <dbReference type="WBParaSite" id="SPAL_0001138700.1">
        <property type="protein sequence ID" value="SPAL_0001138700.1"/>
        <property type="gene ID" value="SPAL_0001138700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="336"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001138700.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52827" checksum="E027F48402DB4BAF" modified="2015-12-09" version="1">MTFQKIENIACVGAGYVGGPTCAMIAYKCHHIKVTVMDINEEKIKQWNSDDLPIFEPGLYEIVKERRGKNLFFSTDVKGTIENADLIFISVNTPTKHYGRGKGMAPDLKYVESVARMIAKYGKDATIVVEKSTVPVRAAQSIGIILAEAQKRNPELHFQVLSNPEFLAEGTAINDLANPDRVLIGGEDSEAGKEAVSRLVEVYANWVPKERCITTNTWSSELSKLAANAFLAQRISSINSISSICEVTGADVGQVALAIGKDSRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLKEPAAYWSSVVEMNEWQRKRFAHRIITELFNTVAGKKITFFGFSFKKNTGDTRESSAIAVAKHLLDECADLHIYDPKVSETTMRTDLLTVIHNKNIVDNHVTVHKCPYEAVENSHAIVVLTEWDEFKTYDYNKILNSMVNPATIFDGRRILDSDELKKIGFRVFTIGTTPTQSYSLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C073</accession>
    <name>A0A0N5C073_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C073"/>
    <dbReference type="STRING" id="174720.A0A0N5C073"/>
    <dbReference type="WBParaSite" id="SPAL_0001140500.1">
        <property type="protein sequence ID" value="SPAL_0001140500.1"/>
        <property type="gene ID" value="SPAL_0001140500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="89"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001140500.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34642" checksum="ABBE0307C861CDA1" modified="2015-12-09" version="1">MFFSINRTNGIRWQGYQNSAGAVLEAFRDAKKNYSVLNSINVSYYWVYNDCVISSAAGKFFEMVNSGNESIDVMIGPACVETAPIIGITTVMPSYNYGARGLIEMLVKLQLYDLSLVYMQSPEFLGMCSKFAGEFDNIISNGYPLTSIVYKRLILNFTNANLQSIANAISKVSRTVVMCLDEQAKTRSLMLAFFDSGMNNNEYVYINVDPDMDNNINEEGKILLKDYAVPPDGRDNDSYSMYNYMFNFQYSMEGGMLQNYNKLRTTMPQLMAEPPFNCTTECEKYNISSVYAPYLYDTTYVYFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0P4</accession>
    <name>A0A0N5C0P4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0P4"/>
    <dbReference type="WBParaSite" id="SPAL_0001157200.2">
        <property type="protein sequence ID" value="SPAL_0001157200.2"/>
        <property type="gene ID" value="SPAL_0001157200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057329">
        <property type="entry name" value="Beta-prop_Rol-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058726">
        <property type="entry name" value="Roller3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25494">
        <property type="entry name" value="Beta-prop_Rol-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26432">
        <property type="entry name" value="Roller3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895147" description="receptor protein-tyrosine kinase" evidence="19">
        <location>
            <begin position="19"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1936"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1090"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1590"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1824"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="2014"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2334"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2425"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2334"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2425"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2447"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="2049"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001157200.2"/>
        </source>
    </evidence>
    <sequence length="2499" mass="283164" checksum="1831BBB82A8D389E" modified="2015-12-09" version="1">MFLLEIIFLLFFSHITSSTIFSNTLTSCIDACVDRNLAIPLKHNQLSWEVNIFDDCDYSCHVTSCQEGCKDLENNESNCTSRCELTQSPEACWQGCRNVIDTFLHTLQELINHVSLTTSIDETQGIKVKFEFEEQYTGVLQDIASRKIQYYGQSKSSTLTSGWKWTPFPENSFKEQSRSTTIFVPFEESASVQFRLALSWRNFTIVSRSLTRHLPTQPYIYSAPKLTSSLQVGIDKYVICYEIYRIPNPEYKIILTKNDGFVLEEQTTTSSCTLFNNLEVDNCCKISVKVIDKEKDLQTPELNVNITLMSIKNDQNQSSEEKSFLIFSNGTHLFKVKDLNDYIMLNDPILLNFVSPKNTKVSTIININKDNLLIGFDDGSIVKFNIENDMEKEIDETKEKNDTINSGLSTTIPLPSSLINREIVKLKEDDGIKITDLAIDPLQGYFYVLRENKGIIRCSLINGCKKEFITKFIAEIGKEIKKISLNYINGELFLTNNVGELFETPLFPFNITGDYSFPSIKKIDGKERNHKFIYGTETINNGTRLITISKNGSLWYMDIVTKKWKNMREDVILNDIYKDVKQFHLSNGRLFWISTSCGDSHPWESCLYSEESDLNGKNIHLNKYLYAGPVVSFTFLNDYYNPQFIQPPGKVGLIINNMKAKVTWLPIKSLPYQDSDIRWRNIFYEVKLQSQNNLLHEVKNISANITSILLNIEPNPKYIASVRCCIPATNICSEYINSENTPFQLPDQSSSDIEDEIIIYSWKKTDDQNLTINDILGEEIKDNGNYYPKIPIDTNAIIAYENSTKSIYFSKQNIISIEKTYNNYPSFRFFDYITVTHLILISKKASIIVASSYSIAIYRLTSTFDYQIYQCFNEKCGEVMGIAVDNDSDEIIYLTQNINGTVQLYNFDVENKKSNLIGESENFPSISQLVIIEQKLIFLTKLGNIGVCDKSLSNININFALKDVLFLLPLQKVSNSTSFENPDLILNDNRVSFDGDIEFGNHQRTELSWKVQPQLPLNHAIYKIQLFRDSFVGDRNVEVSFNTTFNIPQKILDKWNSKQKFDVIIDVITPWTLSTTNKTKIIAPTKPPSPPDSLKIYATQQTTVDGARAIVDLFWDEPKESNGDLLAYQVNCTNLESGISKIEVVNARKTRTFSIATKSGKIVCSVAASNEQGIFGKFSNPISIDSSELKPLVRLFAIDSIGNLMTLTNWTNGIGSHGKSKRQIEPAYQSMDFIGNDLYAIRREPDNNQLFIVLLDLNDVTSILHKVAINGEFSQIDAITSDWIANRLLIVANHQIMQISLELFTSLSVVTPKKMFTLSTASQDVKQLLFDPFTYHGYLLTKNGSLFLVNFKEGTEQNLALSIDCLSSQTITSMMTEYIWNRASSPLIYALTWNGLITIEPKTKVCKDISIDWSVFGEKGIKSISSFSIADKFFVFVTPFQLLVYDRKTATSTPISIVSPPLKQILAVSQSSQPSPDRSCFTLPPSNNIKFTLKNEDKSGALIEIVEPTIPSSCNSISFPPTQYEVHFKRKNTDKIKHIQSVSNIIHVENGILDRDTDYEVSVTWLNRYSPPTSQSEAKFLKTGYGYPSAPQNFNAFSVSPDTVILYWLLPQTLNAPIEEIKYKITQQSSSLTSPSGIGARNFVNGGFSPSSTDAIVCNGNPCQAKVTNLRPSTDYKFWVTAIHESHLKSQLIIDDTEAISNESSVRTKDIPGTLRPDNVTSNYIILRFSSLEPESEPSKLAVEYRQSGVDANYISPSNVTFNLSDISATKSTTIMLENLRPATTYDYRLFATYTGEYEYQGKNKSYSEIFYQTAQQIKTKPGTPTAPQSVTATKDQEGWILRWKSPISDGGAVITSYAVDFRQNSSSEWEIAERGLSPDKLWWRPFTTSSQIPVNPSLMEYRVRATNSEGFGGYAYSKLDENYLIKEGKEKNITLLWVILLIITLLLLAICGVFLFLGYKKKVKRDIRKQKINKTISLDMIGQLNRFPYRMSELPLELKNELNTLPKVNKDDVKYVRFLGSGSFGEVYQGEGKNLPMYGGKTISVAIKSLKPGYSEDDRIKFLKEAILMNNFDHRNIVKLLGVCFEPECNFLLIELMEGGDLLKFLRESRPTQREPSKLSLKELISIMVDIGRGAAYLEMNRHVHRDIAARNCLITSKLPENRIAKIADFGLARDVYNNEYYRVSGDDFLPLRWLAPEAAKDGYFSNKSDIWSFGILLWEILTLGETPYGKRKNYEVITYVNGGGLPDKPEYCPDEIYDIVKECLIFNVSERPSFSVILPKLEDLKCKPDYNDDQSFPPTNEYFGHTNQAFEMSLASIGSNSMSDCIKLEERKESGGSKFDKSNKSIGKKGSKPIFMRSMRKDKSQNFPEPLPSKEELDLSIRRSISRMSGNFRPESGMSSHTLSTTLDPDYEMLAKRSSSIGSYTNEGFNNDNQNSDYYLRPKTSKNSIYFNPSKNKAPQPPNSGIETNYRISHESSLSQSEDNGECSSKTGRVSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0T4</accession>
    <name>A0A0N5C0T4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0T4"/>
    <dbReference type="STRING" id="174720.A0A0N5C0T4"/>
    <dbReference type="WBParaSite" id="SPAL_0001161100.1">
        <property type="protein sequence ID" value="SPAL_0001161100.1"/>
        <property type="gene ID" value="SPAL_0001161100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF375">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="568"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="913"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001161100.1"/>
        </source>
    </evidence>
    <sequence length="1103" mass="126274" checksum="099BF2DD3446A6AF" modified="2015-12-09" version="1">MSTSFFACAEVKKNVLNPSNIITSFGIPSFNDAARFPFKNLTVKIAILIPEDNNKTFSTFGYHSTASAITVGYKDLLDSDFIDQDKLNFDFFFYQVNCTGPLGTKHAIELLIVNEVDVIIAPPCDGLSNFISFVYSAYNRPVYLWGSAVHSLISTSNDIQTTVSISLSFSEYTFGTTEVINYFKWKYIALVYMNLPSSNKCSKFQSDFVANALKDTNIIIQYVAEVNTSASSMKAVLKELKQYARIVVSCMPTFKYKRQFMLAAFDENMTNDEYLYIFLEINNFGFDGNSNGVTALLEGEEIPNDGRDEDAITAFGYVFMIFKENQKTDLSIFSNQIKRYMTEWPVNCNDSLCLSNLNDSNFQSSPFAPYLADTMITYGLALNKTLSTEPLRYNDGVLIKNNSLHEFDGYSGTLKFGRDGARLGMFDLIAFNNSFSSITLLKIYQNSERKYIVNALFETEEEIWFNRLNKKRPTDKPECGFTNNDCNNRLTQRYGTYIIIILVIIIILIISAILVIIYIRKSKKKQQILLDELWLIKYADLKVVNLAKIPSGRTITSNKIIERSLENFNLNREVNGNNVKKLHDENIIEDDEVNTIGYFYKEEIVVGKKFHKHLSIDNKIRSHLRMLREIDHENLNKFIGLTEYKHYVTPIWKYCSRGSLKDWVLNDDMDLEPFYIVSIMDGIASGISFIHNSKIGYHGRLTSSTCLLDNHYQVKITNFGINLLAENFQRTENEQLYTAPELLRASSYSGTKEGDIYSFAIISSELLNKAPAWFDKHEEMLTHEIIMKIKKSRLGNFRPTIHDKYEEKWVKDIIKLVKECWSEDPMSRKKIGVIKTIIKKAVKVKNINLMDYMFQKTENYAAELEEDVRNRTRELYEEKKKCDILLYRMMPKSVVEKLKSGEEVQPEYFESATVFFSDVVSFTDLCAQCTPLQVVSFLNQLYSRFDELIEKYDAYKVETIGDAYLVVSGIPIRNGNKHGEMIANMALGFMESLPSFKLSFLPDYRLNIRIGLHTGSVVAGVVGLQMPRYCLFGDTVNTASRMESNGMPGCIHISQHTEELLSSTGGFKITKRGSVLIKGKGKMVTYWLLGRESEPEKWLEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0X7</accession>
    <name>A0A0N5C0X7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na_H_Exchanger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0X7"/>
    <dbReference type="STRING" id="174720.A0A0N5C0X7"/>
    <dbReference type="WBParaSite" id="SPAL_0001165600.1">
        <property type="protein sequence ID" value="SPAL_0001165600.1"/>
        <property type="gene ID" value="SPAL_0001165600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="93"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001165600.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="67799" checksum="5DD4636F0CEC88EE" modified="2015-12-09" version="1">MNRYSSSVKNTFLNVINNRAFNVILTSIIVFLSIYILIVGFFHRSLIHPLTDTELLPTEEPQLIVDAKDLVENIQESTIKTIISLFFLWFISLIASKIFRSIYLPALIGCLIVGILFRNLEALHDFLSIDVFWADSIRYFAFIAILIRCGIGLDSISLRSHWILCGSIGIISVIFETIAIVCTSYFIFHIPFGLSILLGFTVAAVSPAVTVPAMIDLQEKGRGTENGVPTIVLVSSSIDNLFCITAINLLVSIIFRRTDSLSYTLMRVPVEIAVGALVGIVLGLILRHLPKNDSSVVHFTRTILLVTVSYALAYGCRAINCEIAGPLAVLLMSIVVSMRWKADNNDMTRIEENAFAHAWRLVLEPLLFALIGYNFVISDLNGDIILIGLAVIVIGVVGRIIIVFLITIFSHFNLSEKVFTSFCFMPKATVQAALAPVIYQFLLLDMDWNTHATFFISTCIIAIIITAPLGQIIIRLFGYLLLSKFRIDPFGMKSPSKAYEPNHFMNEINAGLGDNMQSVQTEVLNVLNGTKSIVKPSSYKITPKPIIPNNISDYHHHQYIPSQTSFPEVNNSSYQEFRERRLAELRNKNEIIRSECVTESTKQTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C108</accession>
    <name>A0A0N5C108_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C108"/>
    <dbReference type="WBParaSite" id="SPAL_0001168700.1">
        <property type="protein sequence ID" value="SPAL_0001168700.1"/>
        <property type="gene ID" value="SPAL_0001168700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001168700.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31881" checksum="429E0391B0EBF0C4" modified="2015-12-09" version="1">MNLFDIFQLVYGIPSYICYLIFTIQLGYRLIRREKTFSNPFYILIFYKALNDITLQTTILLLIKISIIPASHDFYYANSYLCSIFNFITMPCYSITFQVMLIMSLNRYIAVGKPLLYEKVFQNYLVCIYIFTTLVIGGLIGVISFNYACTYAYSSILERLYISFIKSDIISFVLAYTFGLYIPLIAISFILNIITIRRLKVKNFIKKMGSSPDIRLSIYTLFGFAMGIVFLSVYILRIANFSTSKIFFNTIGTAILPYIIDIETYGSFYFSLFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C269</accession>
    <name>A0A0N5C269_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C269"/>
    <dbReference type="WBParaSite" id="SPAL_0001208200.1">
        <property type="protein sequence ID" value="SPAL_0001208200.1"/>
        <property type="gene ID" value="SPAL_0001208200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001208200.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22616" checksum="22E3BD7CB98D4CCF" modified="2015-12-09" version="1">MASHLPNDITFTSLDLDRLISLYKDKSIKGKIQGEWEEKILNQLWGVIINCLTREGSKRIPSEFLRLDHHGIKNVFVPPIVEAMNGVKLLKFIQKWYNYNTTNRMHLNDVLPIICLKNINIRQLYAFTKASLRKFSDGEESGKNEKNGESGKNEKLDDFQKFLIMLNLEILKITEEKKRLEEERERQKLINTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C294</accession>
    <name>A0A0N5C294_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C294"/>
    <dbReference type="WBParaSite" id="SPAL_0001210500.1">
        <property type="protein sequence ID" value="SPAL_0001210500.1"/>
        <property type="gene ID" value="SPAL_0001210500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="1364"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="669"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210500.1"/>
        </source>
    </evidence>
    <sequence length="1860" mass="212327" checksum="6EABECDF371819E2" modified="2015-12-09" version="1">MENSNIPLPSAPVAVELDLSVFLGAYEAAKTRWSEQQRELASNPSATQTDRTILVDQQTEELRTLIEFFRVSDDTPYVVPFDWGDGDAHPRLQGLTNTIVGQLSKHGILKPFVKGGDVDFGRWKEKTLRRLKVLAVDNEGYNLVNQLCMSLIEAFIPEQSAATLHLERALAKRVDSNGRLLNGLLLPDLLQEIWLDMRSSQVNRKVQLLAKTPKWITGKDTVVQFNRRYDDYLRKRLGVQNVADYLDKNPALRREYYMNYQSCMPVEYRKEIKFDIHRDLAWIDFLKLFEQEEGFQESFEDTGKNDKLPRFKVKGSINNHKGKQYSVNKNRNFNGKRNGLKKRFKNNKTKYNTQNGYTNNRQSFVPNNGYNNNNIVPYNKKGFNEVNPRNTQRVIPSNVANSGNKSTVHGRGRAIKPVNRGPQVNALNIDSLTDNICTKLQDMFLTAKMSTLIAICLLFLCITPVSGQSTIPEFYPWEKCDAPRIPMFYRLTDTQLNSAMPRAVTLTPIDEECEPDTNREPIIGFEIDKLVVSLVGTAPKLPKEYKHSPAILTKCNPAEVVLVNDKYYTRIEDEDESAIIDLDLNIGFVQDVRKEFLLKCPDWDNTKSEDTDIDDGTETASEGEKDTSLTYPSTGSVFDKFNHSGKISCRSGCRLQRNENNGYEFETNAKRFRKERDGLENSCKAASDKIAQDAQVLSKQKENESEISRLRSEIALLKQDQIKMIQRTTYDTDIAQLKTKLDYEQTNRQTIEKEKKEADEKNQQLEKDKLRLEGQLKTCNNDLSIVKNDLKAKQAELDLLSSAPKEEIVQTDFSLELQTCQKLLSEVKTEKSDIESSLKRQYSNAETLLKEEIVDLTSKTRNLNTVIRRVKYNVDFIIKEIRNIYHKPDGVTCIIRKALENRLKSITSFMAGNTRLEYKQPEEVIAMKTNLKAVENSPHYTSYLDITKKLNTVVKDIDLNPSGQDYESLLTFFGGVITTIVGRIVKEKIGDYLSRRNNNTDSNNTQLNTFSSLGVPTINSPASRITTTPVRGVLVNRHGRIGETVNSILTPLPPNSSHTAWNPNITITMNDELYEALIDTGATINVISRKLRDKLALPMEASTLRITTANGDITSTIGRVQNRTVIMGNAHMLTYDVMENCSHDLILGLPAIKQVGVKTLFSKDVTIPANSCNIIHARVSPDIHSKNDVILDLHSYWKNADQILTFEQVCSINDSMVPLVLVNAGRNPVKLHKDTHIGMVHTIEELDDNTLLVNSEEVVPDDADWEETLPPYSDDMTPLDKTSFIKLIDLSNTLLTENEKKILLDILWEFRTAFHEYDGQPGLYTGRQRLNIKLKTTEVPRRIKPSRMSIEKEREISKQIADMLRTGMIEPSRSPYLSRVVLVRKKDQKWRFVVDFRGINTLIEQQTHVIPRIDKITEDAAGRRYYTSFDLKAGFHQIPLDENSRRIAAFITHDGVFQYKVMPMGLTGSPDKFQEVMDEVLQNIPNCYVYLDDILTCADNVTTHLQNISEILDRICIFGMKISIAKRQFAQPSAHYLGFVLDNKGIHPNPDKVKAINDKPIPRTYKEVKSFLGAASYFRRHIRNFSAIAEPLYKLDKNFEWTDIHDNAFTKLKEALINATTLSPPDNTKNYTIFTDASFQDLGAALVQQDKPIAFASRSLKPAEKNYPIIKLEALGLIYALKQFRPYIYGKHTLVITDHKPLLALLKNKELTGILQRYQMAIMEYDLTIQYIKGDANNVADYLSRDSFLAINVKDGLLDEVFPTNGHPPYHIDKFLQYYDEKETEAIPKTGKIRTPSGTRIYVPQQLREKLLEIFHTHPLLGGHLSFDKMNGRFKRIFYWPKMDTDMMTNWQSCLCDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2L2</accession>
    <name>A0A0N5C2L2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2L2"/>
    <dbReference type="WBParaSite" id="SPAL_0001222200.1">
        <property type="protein sequence ID" value="SPAL_0001222200.1"/>
        <property type="gene ID" value="SPAL_0001222200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001222200.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="33062" checksum="2EE2B5B96746E4B7" modified="2015-12-09" version="1">MIDIFLVIDIIQLIYKVPSMLLMMLSICIIIKEIKNKNINFNTQFYIIIVCKLTNEIVYIMTIFIFIKLPKWGFCNDFLENNDWMATIHFTLLAQETTFMFLITLLISINRYIAVKYPLSYKFYFSKSRILLTLLSFIILSVINGLGNILFNAKYVRVDLFDYIVPSFKSKNEIYYQLFYRIFLLGIISIATCTFNVMAILTLKKHNQNVNKYKKELFYIIYSVFIFITLIFVETYFVCRLISLKYEIKLLSNITNFFHVVAFDLTSVGDFYFLLYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2U4</accession>
    <name>A0A0N5C2U4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2U4"/>
    <dbReference type="WBParaSite" id="SPAL_0001230100.1">
        <property type="protein sequence ID" value="SPAL_0001230100.1"/>
        <property type="gene ID" value="SPAL_0001230100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001230100.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43521" checksum="17D3C2E7680A6A59" modified="2015-12-09" version="1">MQFVINNNESSYDFNFEYHREKRKVRGRNFYLWSKSIPFFIERNLNRNLIVKALREIEQETCVRFHEVKRTYKRMSGIRYSPSNICFSFLGKRLLRGFQKIFIAKHCETIGGIQHETLHALGIDHEHSRIDRDKYLFVQQKNIEPSSLNDFTTPRKIHSNTLGLPYDYGSIMHYSVFSFSKNKEPTLVPKDVLYSRTMGHIRKLSFIDIKTINLLYCRNKCSFKIDCDNGSYQHPTKCFQCICVEGFVGKDCYYFTTNLPPCGKSMHVAQESPREIIVIGKINCYYQLTTEKNSKIMLKVVYTKIYPALGTFCWPENSLEIKYWEDKTVTGARFCGFTENIVFLSKSNVVIVYFRSTNASNIFMLMFKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2W2</accession>
    <name>A0A0N5C2W2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2W2"/>
    <dbReference type="STRING" id="174720.A0A0N5C2W2"/>
    <dbReference type="WBParaSite" id="SPAL_0001231900.1">
        <property type="protein sequence ID" value="SPAL_0001231900.1"/>
        <property type="gene ID" value="SPAL_0001231900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000019">
        <property type="entry name" value="Aminoacylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000001">
        <property type="entry name" value="Aminoacylase-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000005">
        <property type="entry name" value="Putative Aminoacylase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="185"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001231900.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45653" checksum="DBF4A5696370AFB7" modified="2015-12-09" version="1">MGEDIAVTNFRNYIRINTEQPNPKYYEARDFLFKLGKELGCQTWEHECVKNKPIIGLTLPGADINLPAILLYSHTDVVPTSKSNWKYDPYDAIKEENGNIYGRGTQDMKCVGIQYIEALRRLHQKGIKRFQRTIHLIFGPDEEIGGKDGMEKFVKTEEFKKLNIGFALDEGLATEDETFKVYYGERCPWWLKFICHGSPGHGSRFIEDTAGEKFQFILNKALEFRKSEKEKLESNPTYNLGDVSTLNVTIINGGVQPNCLPTEFEMTIDMRINPNYDFDEIERMINGWANEAGKNVEIQYLQKFYPPCKAVFDRNNKFINTFATTLEKMGCKYVTEIFTGATDSRFIRGTGIQSIGFSPMNKTPTLLHEHNEYLNEKIFLKGVEIYESLINNLANIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3F3</accession>
    <name>A0A0N5C3F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3F3"/>
    <dbReference type="WBParaSite" id="SPAL_0001250300.1">
        <property type="protein sequence ID" value="SPAL_0001250300.1"/>
        <property type="gene ID" value="SPAL_0001250300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001250300.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18177" checksum="4C5B9B855789DF2D" modified="2015-12-09" version="1">MILYSYITSTNAYIPKRHKMKAEKPALYAINSERDIEMYLNRVVEENPRLRDFLHREKEIPISLFCDDIQCGNPFSPSKNLSINVYAYRFLINLLNPGDLYHYRYIGATKSRFVKHNRYMEVTTELINLVKQVKIKLKGSNEIISIKILFIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Z3</accession>
    <name>A0A0N5C3Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0001267600.1">
        <property type="protein sequence ID" value="SPAL_0001267600.1"/>
        <property type="gene ID" value="SPAL_0001267600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001267600.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10357" checksum="C4CF59BB756432AC" modified="2015-12-09" version="1">KDCVYHIRSKDENKNVSILVEKVNIYPTYGLFCYAGNRLEVKFESDKTKSGAFVCSQTGETFESEDNYAIIYYKSMGDANYANIYYRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C462</accession>
    <name>A0A0N5C462_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein YIPF</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C462"/>
    <dbReference type="WBParaSite" id="SPAL_0001274600.1">
        <property type="protein sequence ID" value="SPAL_0001274600.1"/>
        <property type="gene ID" value="SPAL_0001274600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001274600.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16014" checksum="96E64DA9F63FCD95" modified="2015-12-09" version="1">MLNKTDWVSFFPKPTGELSRNYSLWDIMTLDQTDMTQFHHMWLGIFTWTTIIITTVYALTFLISFINLHHHSWVVFSFLPFLLLLIIPQFLLNLTTCAVIAFSFSAGGKAITAWHCLGIGCVQSLFSIIFSYTRILQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C690</accession>
    <name>A0A0N5C690_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C690"/>
    <dbReference type="WBParaSite" id="SPAL_0001346300.1">
        <property type="protein sequence ID" value="SPAL_0001346300.1"/>
        <property type="gene ID" value="SPAL_0001346300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001346300.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15447" checksum="F36FBA5427EF0FE1" modified="2015-12-09" version="1">MNNGFEFTDNYSIFSRGRIREIAGDFLFRHSSDREAFIYVNEIRVYTKYDFMLNQFHKEIDVVKYTYSENPLFVTALTESLNVIQTKINLNEDIPNVSKNDEHDLEDIFNNDTSLTFSVDVLVLQKSGINKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6A9</accession>
    <name>A0A0N5C6A9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6A9"/>
    <dbReference type="WBParaSite" id="SPAL_0001348000.1">
        <property type="protein sequence ID" value="SPAL_0001348000.1"/>
        <property type="gene ID" value="SPAL_0001348000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001348000.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14296" checksum="68453DED89283D5E" modified="2015-12-09" version="1">MFNEKEEDPWAIKSVCTFTKLDDESPPNIDGEKFFKKFREEIDNARAKQYARYEEVYNPYDTLYDEECKIVQFSDMDARITTIINDFHGDTNKHNETSNEDELLNLINEIDKVNIIDWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C735</accession>
    <name>A0A0N5C735_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C735"/>
    <dbReference type="WBParaSite" id="SPAL_0001375000.1">
        <property type="protein sequence ID" value="SPAL_0001375000.1"/>
        <property type="gene ID" value="SPAL_0001375000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001375000.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="41012" checksum="D00FDD84AC20CD32" modified="2015-12-09" version="1">MNDRTLKETRIIRLCDLFKISIPSNLGKSELEKKYLLIDRYYRRYIQNSSSRQETNYDDFYNFVNTTINNQAYYDFIAHNIANNANDVLEMDISCDENDQNLLRNEHINSDSYSFYNNSDINMDEIILDEMKPINERNSLFDMEVDLTSNNDLTEIENESIPDEILVNQFRESVADDYNEITDDEIDFSDIYGINDDVMFENLQDNLIDENEDINANIVVNDGNITDINGSSDDKIKFIPINKDNFVIDHIVENTYGRSADLDRLTRNNELFDMLHDEENNVNDIQMLNDSTIQNAQEEVIQLTKKDKKKLDYIEQLENDFKNFNIINFFNLKSKNELNAIEFILKDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C811</accession>
    <name>A0A0N5C811_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial 18 kDa protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C811"/>
    <dbReference type="WBParaSite" id="SPAL_0001407100.1">
        <property type="protein sequence ID" value="SPAL_0001407100.1"/>
        <property type="gene ID" value="SPAL_0001407100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001407100.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25452" checksum="71BD0207A82121F0" modified="2015-12-09" version="1">MKSAAIKGRDFSYYWLFAGWWPSVVNFIDCKIGQPVKDRYNRIIVKIQYIVYGYWLSPVAEKAKIILKKQALILLTYTKNLSIRLGIFLKDSILWPILISGYNIALVPAFEVLKDKYRFIEDNVLIYFLAPVCQTVINVVPEKSPFVEDSDLELDDFLPCENDAESDASWDPDEEEIKRKKEEAALQEKKKRINQKSALIEFPDFNDLGSSDEEFMFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8G8</accession>
    <name>A0A0N5C8G8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8G8"/>
    <dbReference type="STRING" id="174720.A0A0N5C8G8"/>
    <dbReference type="WBParaSite" id="SPAL_0001421500.1">
        <property type="protein sequence ID" value="SPAL_0001421500.1"/>
        <property type="gene ID" value="SPAL_0001421500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000967">
        <property type="entry name" value="Protein CBG11274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421500.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36309" checksum="E0E3C9AC6120D531" modified="2015-12-09" version="1">MTSETEFGYIEEVQPGETLATKKSSYKVIKLLGEGGYGAVYKVQDLKDPNKSCYAMKIEKKVPNREHPKLKMEVAILKLLNLERGAQSHFVRLVDRAKKSNYYLILMDLVGPNLSDLRHAMAKKHFSLSTGFHVAVQCLEGLEDLHKCGYIHRDVKPCNFACGAGTKKRIIYLLDFGMARKIVNENDEVKSPRERCRFKGTVKFASLNGHKGFELGRKDDIESWCYMIADLINENGLPWKKIQDRHKVFAAKQAVRQSYESLFANFKFAKDYGKVLEYVDSLSYPDKVDYYFIYEMLKLMIETEGINLSLALDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8U9</accession>
    <name>A0A0N5C8U9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysophospholipid acyltransferase 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8U9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8U9"/>
    <dbReference type="WBParaSite" id="SPAL_0001433500.1">
        <property type="protein sequence ID" value="SPAL_0001433500.1"/>
        <property type="gene ID" value="SPAL_0001433500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF16">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001433500.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="54924" checksum="6647252B07800993" modified="2015-12-09" version="1">MTVTQSIGSFISRIQNDLIYLAILIFSFAIVYIFRSNKIMKERRYADGVIGFLLTFFLLGYSTLYSLILVIFHLILYKYALKNPLLGKISFIASFFYLAILRVIHHIGFPELKFLSNVVQLIMTLRVVGLSHEIEDAVKNEKHLEKDKSKCDSTTRYIQIPTNYDAFNYFYNFIGLYTGPYFTYQIYSDTLSTPNLYNVGVKAFLYEKLSTLTWSLPSLIVIYIIAPVEFLKSEEVLSTPFFGLIFWMFLAFIYLRLRIYTAWMIAESICILSGIGVYPVDCNNVSCFGPKNVEIYNKLKNRIDIEYDATTISNLDIPNVELSSGYRDGMRAWNRSVQFWLATFVYKRSPKSIRMPYTMFISAFWHGIHPGYFLSFMTIPICTMAEDLIFKIVKVDPKTGERPTWFQFIWLNIRTRGFELMASGFLLLTWNDTVRLWNSVYWWLHIVMLCIIVSSKAYFAFQKKTDIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8W0</accession>
    <name>A0A0N5C8W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8W0"/>
    <dbReference type="WBParaSite" id="SPAL_0001434500.1">
        <property type="protein sequence ID" value="SPAL_0001434500.1"/>
        <property type="gene ID" value="SPAL_0001434500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF9">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001434500.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="44863" checksum="0ECB8F75A3C0542E" modified="2015-12-09" version="1">MELSEYEERYEAKIPIRVVPTLDKRKTESHFNDQYAIVSIIVQPELYYYNFSVNTAKCYANYHNYTYKIIAMNSNPQANNSELYDDDISKKCLHTDIMFRRHCFFYEYLERNKNIVKYAMFLDADTFVVNPYKKLDEFMPKGEEQIIFYERLMNHEIACGSFLVKNTEYGREFFKKFADYQYKMPKSMHGSDNAGIHALLLEDYADKKNIMRDEREFCYRIWRQSANFDDVFKFEACIRYVLANFSESNKNEDVFSFDGGRIKIVKKDSKRRWIRDGIFSGANYCKNDFLFHGFKGNSMVNKTVTIEDIKYNEEDCKTMPIPYLWKVKENKMVRCSVVEETIKGMINSSRQGFWTKFNESMYSKKYYVNKSLYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9K6</accession>
    <name>A0A0N5C9K6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9K6"/>
    <dbReference type="WBParaSite" id="SPAL_0001458800.1">
        <property type="protein sequence ID" value="SPAL_0001458800.1"/>
        <property type="gene ID" value="SPAL_0001458800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001458800.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37563" checksum="206731D664BA98A2" modified="2015-12-09" version="1">MLNIKNSKFPNVSTQFKVNINGNVNYTSGTGFNIELTKLKEIVEKKVPYYRIGTMYVLRAVTLCESMSCSENHEKAKVKKGNIEVEMDFEDYDSIINIENKIKRKNKDSGLLLFIEFKVDRAVIEGYIIREILVIDDLSTYEELFRLEMEVMEKAWDHKLFSTKKIDLIPNENGFNQVEFRILEGEEQKTSQSKATNKTSNSFHRDSLLSSRRTQSDPTNTYSNKRKGSEILHSTSFKKEKKEEPGLDVSLTYSNTNDKENLGDFEFPQSTIVSAIEATINSSGGSSVDISTIREFLGIKHSELASHLLKLTGQYDIFDGMKKIKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9N4</accession>
    <name>A0A0N5C9N4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9N4"/>
    <dbReference type="WBParaSite" id="SPAL_0001461300.1">
        <property type="protein sequence ID" value="SPAL_0001461300.1"/>
        <property type="gene ID" value="SPAL_0001461300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001461300.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="80402" checksum="51B6FC8D6833FA91" modified="2015-12-09" version="1">MKVFKTFTIFTIITVSCIVMVCNRIVRLHVSITPKCLSFSGEIKKENVTGTLLNHKNSTFSQSVTSLCDQKMTISSIIGTDTISKRGTKEELARRIVESGEDGTKLAYLIRRIEQIDPEDLEFSYREPKEEVNGTKSEVVENAKKESTRNSLELMKSVKTMEEGCNVEVFIKRFQLALSAAGLSPQSSEATSWLLMKVSDDIQFRLQEYFVNIEEVSSTILCGKLRNWYSTTMTKAEAECELIAFKLDQKNIEESLKKLKILVSAQNVHLARKDKDDRIRYEILRQLREIPNLKNLGLIGRNFSLDELEAELKIECKLENLHISKNNEGEKNYDKKKIKKCFGCQQPGHIKTECPNVEKEERISNIIEEMDDSNENTIDASIMVNDLVKAVKVFPDSGSKINCINPKLVREMSLTLSEKKKKGALADGSPINVNTIIEQIELTLNGKKIKMRDVWVLDIKHDLLIGTRTLCECDFVIKWNKSIDDDDKMMMQCGEEQQVELKCEIIKKTPDVWLEPDFDLELFKFNSPTIELNNGEISEQNMYDPLSAMRNELSNQVQMKLGTEKIQKFYKLKLVAGLIAVRKKDGTVRLCQDLHVFNKMVRKVRKKNAYWIRKLPIIVDSIKAMRFKDEKYGSFKFNFTNHVSADTNSVNNMLFRQKSCAENRRQVQRKVNKLGYKKTAPLNKIEKITNSGDNWTLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA78</accession>
    <name>A0A0N5CA78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA78"/>
    <dbReference type="WBParaSite" id="SPAL_0001480200.1">
        <property type="protein sequence ID" value="SPAL_0001480200.1"/>
        <property type="gene ID" value="SPAL_0001480200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895707" evidence="1">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001480200.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36123" checksum="7F87A24CAC8A7A33" modified="2015-12-09" version="1">MTNIIYFLSFILINIVVFSKQNDECYQNCENSKLGCKVRLLKSNGKSQSGVYKINEGLLNFTCLFESLPRVVNIRWKFKSSPNVLSENNLPDNGYQSNNDREVYKSIKCDQLKYSHDCSDGSEGHLSYSNCLLEVRDIRMTGYYKCEAVNPLTNQVLGTGVESKIRVIGLQSVDVVESRLIYQKSGYVQVKVCANSYPSITWILRSTILQPGESKQYYSSSKISNVPFKNLDEKDDVVVQSLKNISQHDSYCHYVQLFVSSVKEEIEDLHVGVTNDNGYSLVKLDLKIVNQNCSHKNMIGKSVMLIFLIFLWGFCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAD4</accession>
    <name>A0A0N5CAD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001485600.1">
        <property type="protein sequence ID" value="SPAL_0001485600.1"/>
        <property type="gene ID" value="SPAL_0001485600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001485600.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17844" checksum="CF43FBE0CB7DF912" modified="2015-12-09" version="1">XVDRTKKFCQCVETPMCNLIGMKIHSGCRNYAGLSEIGQEMIRKWSMTAMEKSYNRNLEKRKSRDITLNALIISNNTKSVTKSGKGRRKIRHDKNQQIIYSEDRRHAQLFEGITKFCCRRSNIKTKYMASSMFRSGASTVASNVFILIILFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAF0</accession>
    <name>A0A0N5CAF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAF0"/>
    <dbReference type="STRING" id="174720.A0A0N5CAF0"/>
    <dbReference type="WBParaSite" id="SPAL_0001487300.1">
        <property type="protein sequence ID" value="SPAL_0001487300.1"/>
        <property type="gene ID" value="SPAL_0001487300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001487300.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27588" checksum="8803785CEC0FC4B7" modified="2015-12-09" version="1">MDFQTIYLYEFKLGQTAAKTSRKINEAFGQGSTNKRTVQHWFQKFRNGDTSLRRKEGFREVSVLENEKLKRMVKRNPRITVRELAGELGNCDGIIHNKFINPGETMTSDRYCKEIEEMNQKLSVLKPALVNRRGPILLHDNAKPHVLRITVQKLTELGYETLPHPPYSPDLSSTDYHLFKELELHLRQKKFSKSDDLKNDVLEFLDSRDRSFYSNGINKLVSRWQQCVDCNGTYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAW2</accession>
    <name>A0A0N5CAW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC-TSA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAW2"/>
    <dbReference type="STRING" id="174720.A0A0N5CAW2"/>
    <dbReference type="WBParaSite" id="SPAL_0001502933.1">
        <property type="protein sequence ID" value="SPAL_0001502933.1"/>
        <property type="gene ID" value="SPAL_0001502933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001502933.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8376" checksum="527F98E13C9BDCF1" modified="2015-12-09" version="1">MYNIIWEHRRLSLMACSSWCSLFSHPADYTQAVELRPEFEKRDVKMIALSIDDEESHKKWFHDIIAYGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAZ6</accession>
    <name>A0A0N5CAZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001506200.1">
        <property type="protein sequence ID" value="SPAL_0001506200.1"/>
        <property type="gene ID" value="SPAL_0001506200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="102"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001506200.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26709" checksum="69DFC18478FBBB19" modified="2015-12-09" version="1">MTRYDKDNDRETRRACLKKKKSETKKCKKYKTVVSKFKMKVTSKKPKKDTTKIAKKIESKNFEKITINKSKRVTTTRPEKVATSKPKKRVTNYIKMKYQLYRDINALRKKYSKPPLKVNVTLSKELQKYAQIYVNNFSGKTPKAPLNGLYYFSPPDREYNPIKKWRTDEESLKDDYFMRGIINLPFTRLIWKSSTHIGCGVYGSKTGVITVCVISPMGKYKENPSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB93</accession>
    <name>A0A0N5CB93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TTC7_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB93"/>
    <dbReference type="STRING" id="174720.A0A0N5CB93"/>
    <dbReference type="WBParaSite" id="SPAL_0001515600.1">
        <property type="protein sequence ID" value="SPAL_0001515600.1"/>
        <property type="gene ID" value="SPAL_0001515600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045819">
        <property type="entry name" value="TTC7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19440">
        <property type="entry name" value="TTC7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="815"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001515600.1"/>
        </source>
    </evidence>
    <sequence length="898" mass="101158" checksum="C52D4038D8E539C2" modified="2015-12-09" version="1">MTSKWKGSRLETEINNLRSECNWTKIKELLPNLKSKNISSAEVEYLQAECDLERYIETLHKPGNLTYNEMLKIIEGTCLRVVKKLSDKNEQNTRMEAYLLLGKLHYLCGENQQALYDIEKSRMDASTSQFVTLRSLKMVAEGYAIKGLAIECEALKGANEKLDEDTRIKCFECMKMAAELGISYVSELEKNINHTNRSVNNTKGDVIGHILGTVLRKLPILSMKKSSTDKVIKWDIDGIEWYRKILVNLGDKQICSQAVKKFSKYLAEILVKHRFEKNSSHNSRTMGAKNQSLIFYSGSNHGYFCPNNNIEEILLLLFIAEALISKDIISIKVPETSNIKEKSRENLKVIHSFITLVLSSLGQYELLTNIFRRSMTYAVDDYRLWTFFIYSLIGSGDLVHATKVLRELVLNISENDSTCVRNLPQKYMFLSKLELDSSLQVDASISAAVTALKKTQGTWIEGRATLLHAIAYSSKLQTTLSFEERKLVLAKSIALFEKAIELDPLDDMAYFLSALNYSIARDLDMAQKRCNKAAELNPENPWNLMLLALILTARKNYEAASICVLEALEEYPSHYGLMVLRLKIEMKCGKVSEAIETSKNLLKFWKNANKPCFNSYGPFNSSNEENGISSVKTVSYSVSGKTSGTASKTVLPRDNGYSFTPLITNPITLLSNQSHVSIPTIPSSSDVFERASNITNIFSTAPSEFGAVASTITESVGVRCPSNKSIDLLTTWRLQANIWVELAEMFIEYGKLSEVSSCIDEACNLFPNSHQCIYLKGKLLAKKAETIEDSEVRSKIKTEAKSYFLGALSILPSHIPSLVNLSKLYEEQGMYEMAEKLYRDAITIDPMNHIYWYELGKILSEQGRHTQALECFETSGALDKSTPVIPFSVIPKTIRCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBG9</accession>
    <name>A0A0N5CBG9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CBG9"/>
    <dbReference type="WBParaSite" id="SPAL_0001523500.1">
        <property type="protein sequence ID" value="SPAL_0001523500.1"/>
        <property type="gene ID" value="SPAL_0001523500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="54"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001523500.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28390" checksum="D70D940A29625268" modified="2015-12-09" version="1">XYCGNFAPNPHNFVGDFFFQYSRKHQIDAQSLENSFADVLKRRAANRRGITEPPKRIIVLRDGLTDVQFKDAIHREISALRAACERFQPGYKPSFVMIVVNKHHNKRFFGIDSNFISTNFAPGVVIDTGCTRADYTEFYLQAHRPLLGTSKIPQYSVIVNECDVTLDECQALILALSFSHQIISNSVSLPEPIYQAGELAKRGNYLFAVMKKEDVTRLTYVEDTGQINLTELNNNLCYNKTKFADNRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBS4</accession>
    <name>A0A0N5CBS4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBS4"/>
    <dbReference type="STRING" id="174720.A0A0N5CBS4"/>
    <dbReference type="WBParaSite" id="SPAL_0001533800.1">
        <property type="protein sequence ID" value="SPAL_0001533800.1"/>
        <property type="gene ID" value="SPAL_0001533800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01906">
        <property type="entry name" value="proteasome_protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001533800.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13892" checksum="F320A56CBE6329E5" modified="2015-12-09" version="1">MPYPTRRCCLACDKTVVSNFYVKNCDPHIINVSDNFGTTIGGVYSYGRALTEYALRGTLKHFDSNNVTIKSEKLSKQISKNMHIFTFGIHRPFEVCLFFAEWTPNNGSYLYFVDPTGLRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBY1</accession>
    <name>A0A0N5CBY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanylate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBY1"/>
    <dbReference type="WBParaSite" id="SPAL_0001539025.1">
        <property type="protein sequence ID" value="SPAL_0001539025.1"/>
        <property type="gene ID" value="SPAL_0001539025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001539025.1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6728" checksum="FD36B5A0027660B8" modified="2015-12-09" version="1">MTCTTLFIREIPEKKITGLGEDIKMYNLGMFDLSKQPLRDSICRRRGRNIAPLDITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBZ5</accession>
    <name>A0A0N5CBZ5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBZ5"/>
    <dbReference type="STRING" id="174720.A0A0N5CBZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001540400.1">
        <property type="protein sequence ID" value="SPAL_0001540400.1"/>
        <property type="gene ID" value="SPAL_0001540400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="54"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="253"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001540400.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50801" checksum="5F9D33B466275A81" modified="2015-12-09" version="1">MSNSKSREVISIHIGQAGVQIGNACWELYCLEHGITPDGVMEMDSSYGLEDDSFNTFFSETSSGKHIPRCVMIDLEPTPLDEVRTGAYRHLFHPEQLLSGKEDAANNYARGHYTNGREIIDVCMDRIRRLTENSRGLQGFLIFHSFGGGTGSGFTALLMERLSIDYGKKSKLAFCVYPAPQVSTAMVEPYNSILTTHTTLEHSDCSFMVDNEAIYEICHNKLDLPRPTYTNLNRIIAQVISSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLITYSPICSAEKAFHEEFNVLEISKQCFEPSNQLVKCDPTHGKYMACCMLFRGDVVPKDVNTAIAKIKNNKNIQFVDWCPTGFKVGINYQPPTVVPGGDLAKLQRAVCMLSNTTAIAEAWARLDYKFDLMYAKRAFVHWFVGEGMEEGEFTEAREDLGALERDYQEVAIDSNEGEDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC68</accession>
    <name>A0A0N5CC68_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC68"/>
    <dbReference type="STRING" id="174720.A0A0N5CC68"/>
    <dbReference type="WBParaSite" id="SPAL_0001547700.1">
        <property type="protein sequence ID" value="SPAL_0001547700.1"/>
        <property type="gene ID" value="SPAL_0001547700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000025">
        <property type="entry name" value="Phosphatidylinositol transfer protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001547700.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31158" checksum="5B7C0E04BD5771AC" modified="2015-12-09" version="1">MIIKEYRVVLPMTVEEYQIGQLWSVAEASKAETGGGEGVEVLKNEPFEGTPLLDGNYSSGQYTHKIYHLQSKVPTIVRKIAPKGSLAIHEEAWNAYPYCRTILTNPDYMKENFFVKVETIHLPDNGTTENAHGLSKEELAKREVVMINIANDNEFLHSADIHDETRPSIFKSTKTGRGPLVNGWQNNTQPIMCAYKLVTVYFKWFGLQKMVESYSHTQYPRLFSKFHREVFCWIDKWHGLTMVDIRIIEEEVQKELEEQRKSGQVRGMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD37</accession>
    <name>A0A0N5CD37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNase III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD37"/>
    <dbReference type="STRING" id="174720.A0A0N5CD37"/>
    <dbReference type="WBParaSite" id="SPAL_0001578300.1">
        <property type="protein sequence ID" value="SPAL_0001578300.1"/>
        <property type="gene ID" value="SPAL_0001578300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="641"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="824"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001578300.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="124808" checksum="DF272A3DE351B570" modified="2015-12-09" version="1">MYSKKREYSSSSLGSIILSNNLKERQAKKPKFTEAEDISSDSDVSSNERSNSELSNTKTKPKLISPKETDFNFSTESESESEVEDDDVPLSIFKEYTPLPITEKDILRSLELKGIDYKPDQPPLMAQDVSTFKCIDDGKFYIKDRKNPHKLLQSDNLKSLVESFNEKIIYKLTNERALQPETKPFQSDNNTCDCESDSDDDHELVRLNQREKKSKKNIKKVSSKREQIATYEVLRKRSYSAGMNKEIVFNEAGQKNNGAFCYCSKRHSSSGMRHGYYPNEKPIPKCNFASNEVDKLHHYILKIKTQLHDSLHNQTIISYNNNQFCFEGFSLFFHQEVPKNVTQCFEPVILEDGTIVEYELVSAQNDIMYTVGELEKFYQYFFMGIMELYDLHWYPKSCSFPDTENISCKIVHVLPRFICDNHILPMAYVVKWMTDTFKPICTPETAVAVQTNVHALTKLRRNNIGRIAVNFNLRPCAIRVDDISTVDIDDKKSNRYPKIYHRTTKIPEYSHIHAIEYQETRERANKLQYKFDRRGILSEGEKYELKQLNEILKDYKNLSGRKKCREVSMSSYDYFCTNICSDMIEHAVVLISVVSLVRFNNSLDTLEKEKLKYTFKDRRLLKLSLTHVSKFHHMGTNSDHIKNVLKNLGYKRQKSRNEYINSREKRRERDIAMQMNRHPNNERLEYLGDTVLEVIVTHHLFLTLPDIQEGGMATFRSAMVQNRNLASLASKLMLDHYMLYAHGPDLCNETDFRHAMANTFEAVIGAMHLDGGTRECKNIIGSCMFDDCPVSLKLWNSPPLYNLQAKYKDGDRHLCEKYPYLNSLQNFEKEINIYFKNIRILAQVFCRTSLCKNALTEGDNERLEFLGDAVLQLVITEYLYQNFPDRDEGYMSQLRTCLVSNKTQACVCDDLGLQRYIMPSKPNEDVCLIQMKMKDKADLVEALIGALFIDRGLDMCRLFICEMFMSRLHYFKDDMTWKDPKSYLQQFCLSKHLKPDGSSTGLLPKYKVLKKDIYNKTHFHLVAVYFNDTRIGRGLGSNIVDAAQAASSAALEYLERKDVQAKVFRFDPNRDYSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE73</accession>
    <name>A0A0N5CE73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE73"/>
    <dbReference type="WBParaSite" id="SPAL_0001616350.1">
        <property type="protein sequence ID" value="SPAL_0001616350.1"/>
        <property type="gene ID" value="SPAL_0001616350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001616350.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14878" checksum="A58DCEE46A92AED5" modified="2015-12-09" version="1">MDICAKLLTLITLAKFKKDTNKRITYHQISRLMMDQRKSNSAVLPTNILNVYQFFDYSTQSSQDFEMPIIESMEINNKEYVNDLITNKETFKSTVPEISCKRTMEHNFFKKIQYQLAMYQLKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE81</accession>
    <name>A0A0N5CE81_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE81"/>
    <dbReference type="STRING" id="174720.A0A0N5CE81"/>
    <dbReference type="WBParaSite" id="SPAL_0001617000.1">
        <property type="protein sequence ID" value="SPAL_0001617000.1"/>
        <property type="gene ID" value="SPAL_0001617000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733497" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001617000.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53798" checksum="D936142507510739" modified="2015-12-09" version="1">MLTSSFFVFVTAFVSLVILVASQSNGDKIDKLPGLNFDINFNHYSGYFQVSKTHFLHYWFVESQGNPEKDPVIFWFNGGPGCSSLDGLLNEMGPYTTAEDGKSLKKNPYAWNKFANVMYIESPAGVGYSYSSDGNTTTNDDQTAQENYNAVKEFYKLYPKFRPNPLFIMAESYGGVYGPSLTAKIVEGMGEFKINLRGMAIGNGYVNEKLNIDTSVRFAYGHGIIDEKIWKTLEHECCNECIESCDLTKVEGHCARMVEDIFQFLWFGGLNPYDLYRDCDPNPDVNSKRMKAIQRGVTFLRSVPSYSRLFKTNLYQSYSQPTVMGASVPCLNDSELVSYMNSQETRKALHIPDSVQSWDICSDKITTSYQKQYTDMTPFFKTIIDGNVRILLYYGDTDMACNFMMGQQFAASLGLKRRISKQPWKFDRQIAGFKTIYDGLTFLTIRGAGHMAPQWRAPQMYYAIQQFLLNHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEL8</accession>
    <name>A0A0N5CEL8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kringle domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEL8"/>
    <dbReference type="WBParaSite" id="SPAL_0001630600.1">
        <property type="protein sequence ID" value="SPAL_0001630600.1"/>
        <property type="gene ID" value="SPAL_0001630600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058845">
        <property type="entry name" value="Kringle_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25866">
        <property type="entry name" value="Kringle_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895760" evidence="2">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001630600.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="42361" checksum="541D5DFC5FF9E1D3" modified="2015-12-09" version="1">MFSSVVILTLISQVYSAYYTHKNGNNTILHDLYFDPSNHLEADCITDKAQGYYSYFGRRNKNYQMSFLGKECNSWESVRIHYEMLMDSYRKENNTSQRDKIKDLDFSTVEWGISGYWRHNECRNVRLSNNHPFYKAKGGMSNNGNEKYRAGWNFGPWCYVNIDYNILKNEPLETKINNTLYLNTSVEVNVYPMACFPICTEKQEKRIGNFKSKIQKRKTNMIFNRKAINNINKHFFKSFYFGMMQYYRRTSDRVHASDDFLTFYKISMWGGFLTIIFTIFIVYFCYRLDKYEEKLEKGGILDEEVDDLDKFFEFQKDDDIEEEKENLRNTLLKCQGIQIRRIAKLANNNFTLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEX0</accession>
    <name>A0A0N5CEX0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEX0"/>
    <dbReference type="WBParaSite" id="SPAL_0001640700.1">
        <property type="protein sequence ID" value="SPAL_0001640700.1"/>
        <property type="gene ID" value="SPAL_0001640700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF80">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001640700.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="61178" checksum="C16FEAE39C377B27" modified="2015-12-09" version="1">MYIGKENFFNLEDNIPEKNVCIHIEKNVNNSNNKIDAKKEYPLVILTENPSDKFIPEVAFTRRAFLISDNTIEVPLITTKSFAHNNNNLFLIEGNVGGNIKCQWGRKCPEYYYHGCIFTGYVATFKLPPTYMFSSDNLLLNTSKFIHLSSKTSNQIYSVPLYNSTSILSQNPNFVYKHFLAVFVQPIYYMSDFHVMIQFFEYWITQGATKVYIGRTSYTKDIEKIIKWYNDNKWIEIEFIEWPILPNIYRQIGAQYNKYNQQFNPNLFTFQYEAILSIYDAMYYIRSLRESKYVAVFDWDEIIVLKDNQTRTVTEFLKNQEKNSYIAWSFESRRVTLKKNYNVDKLEDVDFLYFENAKIDTKPFKRPAYQKNIYRPEFINRFHVHLIDKKLPSDKINYVINKVAEIYHLRRMPDIEKKFNQSYTNILKEKGQILTENFKSKLQQDPSITEQKTWNNYFNDITRNLENCRQNSFRESFSHKYGLCVSVEACSNYLNLTNKLDWITSKEKWIIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFD2</accession>
    <name>A0A0N5CFD2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc transporter 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFD2"/>
    <dbReference type="STRING" id="174720.A0A0N5CFD2"/>
    <dbReference type="WBParaSite" id="SPAL_0001656800.1">
        <property type="protein sequence ID" value="SPAL_0001656800.1"/>
        <property type="gene ID" value="SPAL_0001656800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000027">
        <property type="entry name" value="Zinc transporter ttm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="60"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001656800.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42964" checksum="4514A27DC9133738" modified="2015-12-09" version="1">MVTYIDSSDARARLLSDSDSYFEEYSNMTLSRNNFTSRTRKDHCHAGREIKKDKAAEKSIIIVAVLSILFICIEFTGGIIANSLAIMTDAGHMLSDFLSFVISIIAIRLTSLKPTKKYTFGYIRAEAVSAFISIVIIWCLTIVLVIMAIERIIKQDYDVDSTTMLITASIGIGFNLIMGGVLYFSGNSHMHSHHGNSHGHSHDSSSSVEDAIDEEEENHDHESKKQNINVKAAFIHIIGDLIQSIGVFISALIIKFTGWEIADPICTFVFSIIVLFTSIPVLCDIFKIVMQASPNDINTSKVTSDLLSISDVESVHDLRIYNLSMNRTIATVHIVPTKLMSYSSIQKEAFKILREKHKIADITIQIDDSERVDKSCELCYESSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGJ5</accession>
    <name>A0A0N5CGJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Foie-gras_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGJ5"/>
    <dbReference type="STRING" id="174720.A0A0N5CGJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001697100.2">
        <property type="protein sequence ID" value="SPAL_0001697100.2"/>
        <property type="gene ID" value="SPAL_0001697100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001697100.2"/>
        </source>
    </evidence>
    <sequence length="441" mass="49998" checksum="72A630E6F7486587" modified="2015-12-09" version="1">KKECAGDVVDETGDSGKPLLIEALFNVSITFTGQDKIIFEEFIIELEGLFASENYTSLEIVMYSSFKLKKFFLKYPVFYKQCQFLSIGSWGTFYDLIQVGVYLSADKFNGCLIVNESGKFDLIEAFLQFKSKCPNPAAFEVYISQLTLILESTEYSESEKYALIYELILQISAEFPDLKEEFLELEIGTFGSIYMLQEISVQYYRMKEIKKLFKGKPKCEFVSALYSCLSDSKYTISTSNKGYLKILFDKFSVIIANDTLTYAEQIKAISYQYRQFIKTFGYLQETILSFEISAEFGTFGDFIAMFAFGESQECWPEDFLTFPEVTTEVATTEAPTTVPVTGDCSTASSVVLQVVGTQSILYTSAMTSWSSWAAIEKANWKTFCDKIYANYVISTTMTEEAKVTAIIADINAYVAFYYYREEHIHSIQLGAWGTVGQLCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHS3</accession>
    <name>A0A0N5CHS3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHS3"/>
    <dbReference type="WBParaSite" id="SPAL_0001738700.1">
        <property type="protein sequence ID" value="SPAL_0001738700.1"/>
        <property type="gene ID" value="SPAL_0001738700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001738700.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35802" checksum="5614EC496F035DBF" modified="2015-12-09" version="1">MNSSSLSTPEEYQFVDSNKSSTVIFLTVVLSFTIIENLYLLYKSITSDTFERRPLLKNAVICLTLAYIVTSTVHLLPNIIYFYGYIFITKINIKLCSTVQLFGYIIQNTIYLIHFMFALIRYVVIVEEKKFKNCQAYLIGGLVLFPVFYYGISTITTDEITYLKDEICVYKIRATSSHIYHIKILLYTISFTLPLLAFSCSLLIIVKLKRKSKECIFKHEIKKQKQVCVTIAISSLCPLIFELPFLYFFVLSHSAKQFPHIGYRITFLLNFLSYSLSLMISLLFLKDMRQMFYNDFGWKQYTPINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHY9</accession>
    <name>A0A0N5CHY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHY9"/>
    <dbReference type="STRING" id="174720.A0A0N5CHY9"/>
    <dbReference type="WBParaSite" id="SPAL_0001745100.1">
        <property type="protein sequence ID" value="SPAL_0001745100.1"/>
        <property type="gene ID" value="SPAL_0001745100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="14"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001745100.1"/>
        </source>
    </evidence>
    <sequence length="875" mass="102859" checksum="FEB961D957DC369C" modified="2015-12-09" version="1">MTEELILRRLLELPYELTYICCRKLKDEIFAGSTIGTLMIFSKMKNGERGYESKEYVRAIDEKKCPILKLCISEECKIVVILYENQVVVRDLNDCSIVYCQIKKFKKLTSMDCYYDSEKGKLFLCVSDDKMIKFFEWMGDNFRYINIILRPKEFLDSPTSIQWCGRTGILVFALKKEFFYANIFGNDKDEKTCILLKKDIKSKEGPLLIYIDDLNLIGCAQGYSIYFFNSIEPFLSKNKDREIKFTDEIVAVSYSMPYIIAILKNGRLEVRCLQSSEVIQSKATPTRIFMIYPNGKKNSMKTIERHKNEKNFDLAAKLCDVYGVTENEKFEIRRAQAFEYFKLKDFKECMKVVKNMNLEVLQLLQMFIRYLPYNDYPFELNENNDNDGKNLKEPLDGDDLKKLLIELIDYLVDLRHKYLNVVLAYENYTGKYSEEEYQLARRYLVVVDTSVVQCYLHLDSIMVKSFLRSRNFCNFECIEDLLKDLEKYDLLYLHYKNANKHDDALTVLQYLYQKEGSDFSEIDTMIEYLKELGHKEIDTILKYAKWVFSIDEKKGLEIFIDETNEYDEVKMFDRARINEFLANYDIGLSIQYLEFIINVWHDDTITFSEYLGSLYRLRIDELRKNYTHICKDDDKFIGAGEEDGELGELRKKFLKFLNGNNLYSPRKMLESLKSDYFYEEKAIVYRKMKKHKNALCIYISILKLYDEADDYCEIYYDPKDPDDRDLFNLLFEGYMIPFDPNIVGISSDRGLKGSVNVMRALSILEKHADKINITKAISLIPDDIDVNKLKNVFSSIIKCKVEQYDDIVFESAVTKSSYTRCREDLKKRKAVHFKIETGTKCSSCNKGIRDSAFVVNEDGGIYDYGCYTKISYNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIP1</accession>
    <name>A0A0N5CIP1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIP1"/>
    <dbReference type="WBParaSite" id="SPAL_0001769600.1">
        <property type="protein sequence ID" value="SPAL_0001769600.1"/>
        <property type="gene ID" value="SPAL_0001769600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001769600.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20222" checksum="38D1E720F5B48B5B" modified="2015-12-09" version="1">MSFLREKITIWRQYPTLPSTNNINDLESHQPQQMMLWMTTPHSSTLIQSFVHDPDVDETYILTTLYTYRVTDTIPTLMKDRHPTTLQIYKVTDTSDTLLQPYMNESQLFDYIVIKTTLSTLRPELPTTLLHLLSIQHLGLASAPPRARERELLKILQENSTVITKGEEEGRNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIS3</accession>
    <name>A0A0N5CIS3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIS3"/>
    <dbReference type="WBParaSite" id="SPAL_0001772800.1">
        <property type="protein sequence ID" value="SPAL_0001772800.1"/>
        <property type="gene ID" value="SPAL_0001772800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001772800.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10792" checksum="CD9040BA12EA0F90" modified="2015-12-09" version="1">MGTYNCRSLSKGLVDNLINEAIKLNINIIALTEVRQKHKVIETNDLKNCLLMHSESLNGNAGVGFLILAEKYKLHEWALFPGMGFIRLSFEGSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2K3</accession>
    <name>A0A0N5B2K3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA (pseudouridine-N1)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:13933"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2K3"/>
    <dbReference type="STRING" id="174720.A0A0N5B2K3"/>
    <dbReference type="WBParaSite" id="SPAL_0000031000.1">
        <property type="protein sequence ID" value="SPAL_0000031000.1"/>
        <property type="gene ID" value="SPAL_0000031000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000031000.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25779" checksum="C35BF258DD26DBBF" modified="2015-12-09" version="1">MSSEEPLHKKAKTDQVDLEKRKLIVVLEDCPLETAKVGEDYVILSSDKHVRYLMRHKKDPSEYRPDILHQCLLNLLDSPLNRAGLLQVYFRTKKNVLVEVSPQCRIPRTFDRFCGLMVQLLHKLQIRSADEKVRLLRVIKNPINDHLPIGCPKILMSVKASECVRPSQIPKDNLNDNYVIVIGGISKGKISTDYTDREMKINNYPLSAALACAKVTSGFEEAWDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2M1</accession>
    <name>A0A0N5B2M1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2M1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2M1"/>
    <dbReference type="WBParaSite" id="SPAL_0000032700.1">
        <property type="protein sequence ID" value="SPAL_0000032700.1"/>
        <property type="gene ID" value="SPAL_0000032700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000032700.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21461" checksum="0F4510D20553ED5B" modified="2015-12-09" version="1">MATKVVKSKKKDIVKVIHGTLLKTNIRAQCASAAPPLGPMLGQRGLNVANFCKDFNKETSHIVSGAILPTRISINPDRSYDLEICSPATTWLLKKAAGIERGKSTNDEIVGMLSVKHIYEIALVKSKDKVMVGVPLEDICRKLILTCRSLGIKVQKEDLNPEELKRFLDQRKETVTAQLQELADKKAAKLLRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3S5</accession>
    <name>A0A0N5B3S5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B3S5"/>
    <dbReference type="WBParaSite" id="SPAL_0000072800.1">
        <property type="protein sequence ID" value="SPAL_0000072800.1"/>
        <property type="gene ID" value="SPAL_0000072800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000072800.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17354" checksum="05B8AA1E93B5B35B" modified="2015-12-09" version="1">XYCFVTLTTIGFGDFVALQKDGALQNRPEYVVFSLVFILFGLTVISAAMNLLVLRFLTLNTEDEKRDLREAKLAARGLMTIKNLQKTDSGRTGKLLLLRNRKSSTGTSSETEETPVNVEPDTISNCSCSCYQLPYNVYQGTSDMRQRLVNLSPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Y5</accession>
    <name>A0A0N5B4Y5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000113400.1">
        <property type="protein sequence ID" value="SPAL_0000113400.1"/>
        <property type="gene ID" value="SPAL_0000113400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000113400.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41336" checksum="A2FEE482C5F890C6" modified="2015-12-09" version="1">XNDNDDIDDFYMLDKDENNLSYVFKHKPHTAITTSLNVLILYKSSLSRRKDGTGYTFNLLIADHEGYTGECACFKCDSSSEIYGTIEVGGYYTLKLTNGGIFVPSANVDEKKNEKKKNSGSTGKKIILSVETVTFSPTDRKFKFNGVNIVNFQDLNNISELNRNGTKFNTIGVITKDYEELCTKVKKMSFDKIEYPVLSSAPMINDVLQNGKYLMHLCDTPPYEIKAAEICTIAKIASIGFFRRSNEEKKKDCGPFTKSAIIYDPLVHIGGVTIFANRLSKLTLKFISNFSQNIEINKNGDVVFKELLNIPLLKRIKIGVFVSRSNSNKVSSPKTNRVVDYIDICPDAFYIQWLRRMEKHFEGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5H2</accession>
    <name>A0A0N5B5H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Autophagy-related protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5H2"/>
    <dbReference type="WBParaSite" id="SPAL_0000131500.1">
        <property type="protein sequence ID" value="SPAL_0000131500.1"/>
        <property type="gene ID" value="SPAL_0000131500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000131500.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="62469" checksum="823DE20772377E79" modified="2015-12-09" version="1">MSLDTLDDVDSLTDILKMLAEERTNYNEVLAFQFHKTFSMHEPTFTLTIQDNGPNEEFTILCNKSTYKQYTLEDTMENLENIETKNLEHNSTVNIVINESPKRLRNHELESLGKEIASFIEFVFLRYPLAYILNLSYIGSGQSSSLPLFILYRVKCQKIKIFSGITIENIMAFSLLKSLALTNIVEGLTKLNEYILEIPPISPENLENVQKKLNILFRWLPHKTGCSLTINTNLNFPNDQFFNDLILDVERIGLQANIRTNTSINQNFFTSLMEIKANHKPNYVYHISEVEMSFTKIQDTKHFEKLLSICCNLEKITLTVTEEFIDNLLTEGKSRDGSRTIIKDSFSYCSTLKNLRSFFIEFQVTIEKTDVSKKSFVSFLFNAIFSVLPDNIENFSFERITFLNEDNTKMLNTKAGSVRSVSFAGCQDVPQDLIFKFPNLLQVCMVGEMKLFIPLSVYMVIIKYPSGNSCGVDMNDLVPDGSITPGYKENNYYFNLFSRFFNNSIRNNSIREPWFIVFLENIFEYPNYIEVMDMFPLSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5W2</accession>
    <name>A0A0N5B5W2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5W2"/>
    <dbReference type="WBParaSite" id="SPAL_0000145400.1">
        <property type="protein sequence ID" value="SPAL_0000145400.1"/>
        <property type="gene ID" value="SPAL_0000145400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000145400.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16901" checksum="E46EA190B42122B9" modified="2015-12-09" version="1">MFYFKKLNFTFITKYIYIINILTSLSHGIICKSYHKYYEEFKKREIVESTCYSSTPYCVKAIYNDPNPSKMNGISYGCDKNDCIDIEKAAYGWDKNGCKKSSDYGKNGLICCCSGKDYCNTSSTDITISLMTTFIFLIFFITFHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6B9</accession>
    <name>A0A0N5B6B9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6B9"/>
    <dbReference type="STRING" id="174720.A0A0N5B6B9"/>
    <dbReference type="WBParaSite" id="SPAL_0000160900.1">
        <property type="protein sequence ID" value="SPAL_0000160900.1"/>
        <property type="gene ID" value="SPAL_0000160900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6 8" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="9">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="27"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000160900.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34961" checksum="41BF2E3FFA459E8E" modified="2015-12-09" version="1">MNEEIRKDIENDFYKHDLIVPHFVSAPMVRYSKLSFRLLVSKYGADICYTPMIFANCFSTNKRCTVAEFTTIPGEKPIVQFAANNAEDFACASELVCNDASGVDLNCGCPKKSVTSKQCGSALLKNPELIADIVKQTRNRISNSDFIVSCKIRIDEDLNTTVDLARKLESAGLNRIAVHGRTKNQASSEPCDYEAIRVVKDSVGIPVFANGGVSKYEDLIEVAKITKADGIMVANGLLENPAIFCKQKYPSLDCIKDFMDLESEHGLIFDLYHQHLIFMMRHMMPKAERLYFNELRDIVSVKSFLNRYINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6R8</accession>
    <name>A0A0N5B6R8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6R8"/>
    <dbReference type="STRING" id="174720.A0A0N5B6R8"/>
    <dbReference type="WBParaSite" id="SPAL_0000175400.1">
        <property type="protein sequence ID" value="SPAL_0000175400.1"/>
        <property type="gene ID" value="SPAL_0000175400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000372">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000175400.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="34208" checksum="CE6BF2EDC2996830" modified="2015-12-09" version="1">MSSEEDTVDGVTEGFGDTSISRDNGYKPGEWQFNIDDPSNYRVFKLDDKIHCFPVPKLPQKKYYRQRAHCNPMSDHNLNYPIEPLAVDWYQWYGEESRTNKVEFLDIGCGYGGLLFRLSEEFPTKLSMGMEIRVKVTDYVQDKIIALRQGLPGLYRNIWCLRNNTMKYLVNYFEKGQLSKIFILFPDPHFKKRKHKWRIINPTLLDEYAYVLKVGGLIYTITDVPDLYDWMKEHLDNHPLFERLDVDELHKQGDICVNLIHNSTEEGAKVSRNKGLKLPNIYRRIEAKKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B738</accession>
    <name>A0A0N5B738_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B738"/>
    <dbReference type="WBParaSite" id="SPAL_0000186600.1">
        <property type="protein sequence ID" value="SPAL_0000186600.1"/>
        <property type="gene ID" value="SPAL_0000186600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000186600.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16050" checksum="95A55B65F64422F6" modified="2015-12-09" version="1">MHAPEVYHVFPFAVEYEGPCSWRDYLQIEEKTSKDDPSVVKYTTFRGKMLLGRSLKLVKDLIFVHSKEKDSEMPVNEIIFWSYFDGEYPHPLKDELLRPIYKDYIDPESSIFKTKNNKTTGGGDFITELTKSLEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B797</accession>
    <name>A0A0N5B797_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B797"/>
    <dbReference type="WBParaSite" id="SPAL_0000192400.1">
        <property type="protein sequence ID" value="SPAL_0000192400.1"/>
        <property type="gene ID" value="SPAL_0000192400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000192400.1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4253" checksum="DB9E5EA21C146809" modified="2015-12-09" version="1">TAGCRDVFSDCAKNARVCNLPAYRDFMRQNCAKTCGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8G4</accession>
    <name>A0A0N5B8G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8G4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8G4"/>
    <dbReference type="WBParaSite" id="SPAL_0000233700.1">
        <property type="protein sequence ID" value="SPAL_0000233700.1"/>
        <property type="gene ID" value="SPAL_0000233700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="543"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000233700.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="102951" checksum="3FD7A60BB1B3BD05" modified="2015-12-09" version="1">MDWSSSSQNIVKSDDSNFLKLLNEHRSALSDNISTNEKSYCNNLKMMTSKERKVLGKFYSSITADIHDEFEFPKKIKIEYRLDELLNSLIKVVDEFLESDNLIFNGFKNMKYVELLIDIKHVALFYSHLEKKFKEYIPKELCKYINVESDFAISDYDFLSKFVQFYNSVNSKIYQLEIYFKKLNQNGLLANSTLLPIRKLVNNVICQVFESFEYSSYQDRIGTCFINCLRNIVKDSNFDCGFYQKTWNLMAEIGMDKSLRNDIFEKFKKYNTEDAKRLVEYDSIIDWTDYVCDELRKLKEALILLPLSYSKQSLIKSTDEDYKKIIESPFINILEAYPTNDSSSIRFTQGPTSLNTFSLCKNINSGKNIPPVAYDGIKYSGNSILSLTTNDRKIDPNFSVNSDVEYTVYFQAEISMLEAARLEYCTAITDLLDQCNDKMNVLYEEQNICHLKKLYKLLPVAKENAKVFIQSFLNFILASIGKIIEDSGNETKFINDLIELRKFCFEKLLDCYDRDPLYIDCINISFRRALNKSTNKICVGSTIAKYLDKVLKNWHLRKDDNEIFEQVVQILRHVDGKGPFESKYHSLLAKRILNDTAYDESAERQMIQLLREQIGDKIISHMESMLLDIELSRQILQDFRKYVSKTEYHDMYIYNNSDVKILTSIKWPVTLTSNIIYPQEFIQFQELFEKFYNPKHKKKRLHYQPNLTDVVITATFDTCVKELIMTLVQATVLLLFNSHEHLTSTEVQKLTGMGKEDIERSIRSLSRENILIFSNKCYTVNTQFTHPQQRINVRQLHMKAAPILQELSAADKKEAQKNLLEAATCRILKLNKQETLVSLHQLAMKETKLAVSLSEFKVIVEGLITKGFLERDKVNKEVIMYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B946</accession>
    <name>A0A0N5B946_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIR Superfamily Protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B946"/>
    <dbReference type="WBParaSite" id="SPAL_0000256200.1">
        <property type="protein sequence ID" value="SPAL_0000256200.1"/>
        <property type="gene ID" value="SPAL_0000256200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000256200.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18219" checksum="55FF2131EF2ACA85" modified="2015-12-09" version="1">MQPSRKSLFEKEVDKLVEMFKDLSITREKYYYNSMDELLKACFNFSQGMRYVETRNRNMSKYTIDKPRYQNYYKDCKAVHLTGYISFGEHITTYSRLSEIGYGIGERCILHFYGLQYNDFGFSSGEYNESAKSLKLSANIHSKLYRTSYDTHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9E5</accession>
    <name>A0A0N5B9E5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9E5"/>
    <dbReference type="WBParaSite" id="SPAL_0000266100.1">
        <property type="protein sequence ID" value="SPAL_0000266100.1"/>
        <property type="gene ID" value="SPAL_0000266100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000266100.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13141" checksum="3ADF4071834BAEE4" modified="2015-12-09" version="1">MIIKFWSLILLLSYQLVWFTVYGKVNSIEKLKALAEALDGYDDLKDIKEIALKKLRYQRHFEKKYEGKSPHEGKIVKKHKRRSLNNSTYKNEKGNAKNQIMLTKPYWPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA98</accession>
    <name>A0A0N5BA98_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA98"/>
    <dbReference type="STRING" id="174720.A0A0N5BA98"/>
    <dbReference type="WBParaSite" id="SPAL_0000296800.1">
        <property type="protein sequence ID" value="SPAL_0000296800.1"/>
        <property type="gene ID" value="SPAL_0000296800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000296800.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22423" checksum="E62BC8AD7204CD88" modified="2015-12-09" version="1">MAKVIRNCFVHRPNNRVWKHLPRRVEGVREYDFEKNQAMPRDFPDKLQEEPSKLLLVWLYRGLSGEPIWTKEKVKKLFGDVTPGKMHIFKNTESYNNELWHIKHLIEVKPLKFPNGEPTEEDIYRVEVQPDGNCIIDKKKELNPETVMLVDPMKQMTTGYLSSKFASRYNSHKEIYEDTVYGSKNISIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB67</accession>
    <name>A0A0N5BB67_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB67"/>
    <dbReference type="STRING" id="174720.A0A0N5BB67"/>
    <dbReference type="ESTHER" id="strea-a0a0n5bb67">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000327900.1">
        <property type="protein sequence ID" value="SPAL_0000327900.1"/>
        <property type="gene ID" value="SPAL_0000327900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="8"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000327900.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="64007" checksum="8E76508712BDAF98" modified="2015-12-09" version="1">MGYPKHEYKTRDGKIIGRRNVKFTSVVEFLGIPFAKPPVKDLRFKPPQQLKKVVPSDPFYADKPANTCLYAYEKSFYYGFKGYDFWHPKSLQQSEDCLQLNMWIPKKHDGSVLVFIFGNGYDFGSPSLRVFNAAALAHSSGVIVVNLNYRLGVLGFGYLNGNKDMPGNMGLLDQQMGLKWVYDNIESFGGNKKKITLFGSGTGASSVTAHLFAPGSEKYFIRLIANSGTMLNTWSFQKTSMASLNLLALAKKFKCMGSDIQIIRCLREVDGRKLIVEAKLIVNPDQSPLVQPFIPVESEDNFFMGNIRKKLFKREMKKDCDVMLGVTKDEASYLMPQFLKGPNYGCNFKKDKEIESKDNMCLMNETHFNNVVKLIGFYHKYPKEDLDLLYKTYADNTVKEPRDWTKKLLSDFIFKCDVASFGMDYLSEVKGSKYYYQFNRMARVSHWPKWMGVVHGYELLYEFGYIRTHWKYYSRSVRGKEKKLAIKMMKLIGKFVKEGKLHNKWKQITSKDVPVAYLDDKYSSKKGPSSVKSALTEGCKVIRQIQIKHPNIYWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB92</accession>
    <name>A0A0N5BB92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB92"/>
    <dbReference type="STRING" id="174720.A0A0N5BB92"/>
    <dbReference type="WBParaSite" id="SPAL_0000330200.1">
        <property type="protein sequence ID" value="SPAL_0000330200.1"/>
        <property type="gene ID" value="SPAL_0000330200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000330200.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25487" checksum="C3F8C410A3D121DE" modified="2015-12-09" version="1">MSNQMRRRLMMDYKNIKNDPPPGIEARPNPENISEWDCIILGPIGTIFEDGVYRLKMEFKDEYPINPPVLRFITKMFHPNIYVNGDICLDILQKRWLPSYTITSILTSLQSLLDDPNCDSPANAEAAELFQKNRPEYNRRVSEVVMNSLLFNGKLTKKQERKLEHMDRTKIPYLEDLNVSDFEKDLFSDSDDDESEETSGTHSLETEKSSPKSSDQTEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCS6</accession>
    <name>A0A0N5BCS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hormone-sensitive lipase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BCS6"/>
    <dbReference type="WBParaSite" id="SPAL_0000382100.1">
        <property type="protein sequence ID" value="SPAL_0000382100.1"/>
        <property type="gene ID" value="SPAL_0000382100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="392"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382100.1"/>
        </source>
    </evidence>
    <sequence length="967" mass="108306" checksum="A15E524B54CA56C1" modified="2015-12-09" version="1">MNISNDNGKVVSSSNNILSNINDLPNDDMNDNNNQDLEKSVSNDNGNIDGPLTVPKKIEARLTVNREAVFKLIQQLCSQAIEQFSSNSNCQYTKRFTASCQEISEYSTVAYDLLIKMNMIAPKFDFDENTPGNGFRSIICVCDTVVLHIISLLRSCCVMKNSLMFRISFFCKEIENYMAVLRFWILSSQQLIGSISYEEPDNDNLFPPIDIDDYDQYFSVLKTLETLDATCFYSRSLGFQFCPSVCKMFKIIGILLATYSLTWEKGNGAFGSLVKSAKFLLSPEERASRIIKITREADVEFCKGFWNLPELGALPALPKWFGITLAICELREIGSNGPLPLETNDGGRVLIPEPTAHTGFRPIKYRILSSVHRYHLSPVTQNSKSPLSPYLIVHCHGGGYVATSSKSHEGYLRAWAKQSNCPVVSIDYSLAPENPYPRPTEEVLYAYAYMLNFPEKFGWTGEKICLVGDSAGGNLITSVSVRMVNLNVKRLPNSIVPIYTPFLFQYLPSPSRVLSFMDPILHMGILLRCLTAYTMGDVEINKLPLTTNVPESESSEKKGEVPPKNGHRSLLEYVNELKNSQIGNIFKFDNLSDSIVAYYNCSNNRSEENTIINLPAIEGVTNNSQNKTDIPLTSANDSLLHNFGEEEIEGTPYNRTQNVKIFRDPDNILLSSENYDATLIELFKNNNDFTNVKEKKAKLQAQKNFLTKSATTNFISSLFSTSVTDTKTVSQDKDSEESNYQTPSESPSGIQIPVPVKLQLEPKQSIASISENNLAGLSNSPTQQKATDSPDNFIQQKKKTLSQSLAQTASMAATYAIDNISEWFEAEKKPIGHVDKQKLSRAATMTPKMAAEHQKKETEHHKSTLDELLKLKIPRHPEISPMYADDELLRRLPXXXXHLDPLLDDTVSFAKKVKKAGGDIRIVKLLDNLSHGFLNFTMVSPECKKGSDICLDIMMKSLDVPENFYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BED9</accession>
    <name>A0A0N5BED9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helitron_like_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BED9"/>
    <dbReference type="WBParaSite" id="SPAL_0000436200.1">
        <property type="protein sequence ID" value="SPAL_0000436200.1"/>
        <property type="gene ID" value="SPAL_0000436200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000436200.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="52531" checksum="7C5039F331DC150F" modified="2015-12-09" version="1">MVKTRSRSAPKPIPITGKDRRVITKSEEFDEIVRKACRDAKEESTVESDDVDPSDNVPPIEEYDESIGRMATDDEEKTLRHVVRDMGECFENTMILNNSKDDDQYMMTKKVDARRLVEGMGYQYNCFIKEDMKRYSIPPCEKKPVDLRHVDNLKMDKRFCESKVGKYVINSCAKSDNGSIVVSDKDLRSPSQQRGLMNVRQSKFGRDYPNISKSERVRRNARMSQYESSENESYRRFEEMRQYPVYPQYGSYRHMPMMPVYNSNVKIDAYDPKESFTLFYERFESMLLLNGVPSHLKLPMLKLHLKGRVANDVQTQREIKNDYKRLVDYLKRNYTGEESIAAARHKLSSLKINRGVDLINVGNEISRLIDVIYVEESHEDRLRRKRRHFAELLPVGIIRSLIKDNRPLCEPFDHTIFVAKDYWDDMNAGSKMVKDDKGRNERTGKFQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEM4</accession>
    <name>A0A0N5BEM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEM4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000444800.1">
        <property type="protein sequence ID" value="SPAL_0000444800.1"/>
        <property type="gene ID" value="SPAL_0000444800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="278"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000444800.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="69448" checksum="A296389F93F3E0FF" modified="2015-12-09" version="1">MLSPGNYESKAKVLEMIKESDREIWEQCNGNYDVVETCSMFANGAEINLMYDVILMDDAIIFCAKSNILDNEEDKGAAVILMVRSRAIRRTAELCVTKETAQYLDPPCSHIILTIPVNNCDTDSMEIIKRRLSAFCGVSLDDTNEVFSSDVSDLLDLEIINFSQFKECIRPFDLKPVYYFNSNHNGLKCIAIIRDNYSIYRSSIIFDSFLEARESSKKDIDTVSTGNFKVVKTDDIFDELLNKVVCKSRNVETNGIYYMNGRAFKSLFPREWLHCDIIDIYLLAFKSLFPREWLHCDIIDIYLNKWREQISKTNCSPLMEKYKVKIYDTFFFTRLIRRVEFDISSGTIENSSFECLHENVTRIANEKVYKLSSMYSTIFDFDLLVIPININDHWVAGIIHKPGNCLQEIKKENEDWTDINDFQSSILIYDSLINDLISYKQLCFTVLKKYMEACYGKINDSTLGKEMLFNKEKIKFFDIKDPYQQRNGYDCGLFMLEFIRQVLVNPKSVVKLIEGHSMKDVFPNFYVKCGREYLKSYVFSKIDFSKWIALYEMEQFFLVNKYGMEFKTLRSRPTECIRDKSKLKVRRRSKSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF04</accession>
    <name>A0A0N5BF04_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF04"/>
    <dbReference type="STRING" id="174720.A0A0N5BF04"/>
    <dbReference type="WBParaSite" id="SPAL_0000457400.1">
        <property type="protein sequence ID" value="SPAL_0000457400.1"/>
        <property type="gene ID" value="SPAL_0000457400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000457400.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20492" checksum="079CC258D0C233A8" modified="2015-12-09" version="1">MSKKCAREECGKTVYPIEELKCLDKVWHKQCFKCTVCGMALNMKNYKGYNKMPYCEPHYPKTKATIVVDTPEMKRLADNTKLQSKVQYTADFEKMKGTKIEIVDDPELQRHLKNTQVVSKVAYQGELEKKKLMEEVRPQKEVDEKSDSGISNASQCISSTNEVFPYYTPYKGFQIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF20</accession>
    <name>A0A0N5BF20_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF20"/>
    <dbReference type="WBParaSite" id="SPAL_0000459000.1">
        <property type="protein sequence ID" value="SPAL_0000459000.1"/>
        <property type="gene ID" value="SPAL_0000459000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894485" evidence="2">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000459000.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12683" checksum="F6451E28F4D8462E" modified="2015-12-09" version="1">MKSIKLVIVFILLINILLTESFESKNDLVSNNIESIDNLQQPAILNDEEDTNSIEKRQSRPKKSKAKKRRNKRRRIQQVKNALTQLQSQIASIATRLDTLTTTVRPNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF53</accession>
    <name>A0A0N5BF53_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF53"/>
    <dbReference type="WBParaSite" id="SPAL_0000462150.1">
        <property type="protein sequence ID" value="SPAL_0000462150.1"/>
        <property type="gene ID" value="SPAL_0000462150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000462150.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16658" checksum="67F58789744C0156" modified="2015-12-09" version="1">MSKYDACKGSECYTLIHYTSSGIKIRRGCVNKRMELTEYQNDPSYEIFYCNSSSYCNDDTADISKVKSSSGASGKKYFAPISWGMNIVSSMRFQKGCTPPGGLEPPTFRLTAERANRLRHGGGIGRIPHFPSQMPILITFFWDTTFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFS8</accession>
    <name>A0A0N5BFS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFS8"/>
    <dbReference type="STRING" id="174720.A0A0N5BFS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000484000.1">
        <property type="protein sequence ID" value="SPAL_0000484000.1"/>
        <property type="gene ID" value="SPAL_0000484000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000484000.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55826" checksum="4AD12041DBB91782" modified="2015-12-09" version="1">MSLICTICTKAYTSNGTEHALFSTKCGHLFGKSCLEKLAREKNKGGKFNCPVCREYILNSDYHPIYDVPNEFFEIVLNDTEDKCKSEDDVMKRCALGTLKEKHFLIKQDIGEDSDYDECTIEHFDASNGYILVAGFVENYSEDDDVNTFSFLKIYEDKNVIYSKIFAPTIITAVAFNKSCEDCLEFCVGLENGVIQNTVIFFSSGVVGTPHETVLFNENEKIRSICFLRYNDIVYSVGDRRTSNLFNIQIDRVHLKKNWFEDVEVELKKVTSLKVLNDRTLFGIMGGKIYVFEENEIPYVVYSEDYVRFDGYEYDSVTNIMFIKAVQSTNGSLFYGTPKLLLIRIKKNYIYDTKGWRSEKYTSYSIGDFQDDSCNISLSLRSLPITTKRCGGNFTYTFVPDDKSGVLQAYFVNNDGLIELLCEEKIKHLIEEKNGDLWDCIGIIALNKPQFFTSKIIKIPIVIIFDRGFMVYNFYSSIDGVESRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGD5</accession>
    <name>A0A0N5BGD5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGD5"/>
    <dbReference type="STRING" id="174720.A0A0N5BGD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000504200.1">
        <property type="protein sequence ID" value="SPAL_0000504200.1"/>
        <property type="gene ID" value="SPAL_0000504200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051989">
        <property type="entry name" value="FKBP-like_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46046">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46046:SF6">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894222" description="peptidylprolyl isomerase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000504200.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30247" checksum="9D59DE13A906380D" modified="2015-12-09" version="1">MNYILYLIFISIPLYVTGDDEKLEWTDEDGLYIKIIKPIKKEKCKIVSQSGDILKQYYKLTDENGNTVGSNWGKKPYTFTLGKKQVIDGMERAMTGMCVGEIRKVVIPGNLGFGSEGRDNDKIKPNQTLYYKVQLIDIERVTPGKEWIDEDGLRIKVTHKIDPSKCRKSAPGDRIYQHYTLKLDDDTFIESSYTNDKPFVFTLGTNSVIEGIERAMTNMCEGEKRNVIIPQELGYGAEGSPPDIPPFSTLNFDIYLYKLIKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGF3</accession>
    <name>A0A0N5BGF3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BGF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000506000.1">
        <property type="protein sequence ID" value="SPAL_0000506000.1"/>
        <property type="gene ID" value="SPAL_0000506000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF375">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="521"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000506000.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="101844" checksum="7F75DBACAD0D0E18" modified="2015-12-09" version="1">MNNLKIGMFFPLEETSQIHWQGYQNSAGAVLEAFRDAKKNYSILNSINVSYYWEYNECVVSSAAGRFFEMVNSENDSIDVMIGPACVETAPIIGSIAAYYNFPVFLYGLSSVFNSFTDTTLYPTVTTVMSTYNYGARGLIEMLAKLQWYDLSLIYMQSPESLGMCAKFADIFDDMISNEYHLTNIIYKRLISNFTGTYLRSIADEISRVSRIVVMCLDEQDKIRSMMLAFFDSGMNSSEYVYINVDPDMDNHVDGENKILLKDYAVPPDERDNDSYSMYPYMLNFEYSMKGGIIKNYDNLRAKMPKLMAEPPFNCTTECEKYNISSVYAPYLYDTTYVYFSCVAQAMADNKDNKTFKDLIRDGALIANYAVGSFEGITGEFSINSLSMRDAFVTLGTYLNNGLNMIKWIEATVGSETLSVNLLYTDPKTTIWALRGGEQPLNEPKCGFTNKKCPYDFIQKNPIVFGVIILGCIIIIILIILLILYFYIQKKREEEKQNDLWKINFNLLIKNEEYIKPELMVHSRKSFMSASQTSVRLSIKHDPEGRYRLFVYNNEYVMGKFHDCIYVLTRKDMAHLRSMRMMDHDNINKLVGFSLNGPALMSIWKYCNRGSLVDILTNDHLNINIDGFFIYSLVKDTVEGLYFIHNSPIKVHGNMSSRNCLINERWQVKLSDYGIPFLRAFEEQKPEHLLWTAPEILRCDISHPNKKSDIYSLAIVIADLINKRISFEYDNLGGYANEVIYIIKNRKTLPYRPNLNPAVEDIPPAMLHLVRDMWSEDPSLRPNLDVVKMLVKQMNLGRCSNLMDHVYNMLEKYAASLEEDIQARTKELVEEKKKADLLLSRMLPKAVAEKLKSGQPIAPEHFDSVTIFFSDVVSFTVLASKCSALQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGI4</accession>
    <name>A0A0N5BGI4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein sleepless</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000509000.1">
        <property type="protein sequence ID" value="SPAL_0000509000.1"/>
        <property type="gene ID" value="SPAL_0000509000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894238" evidence="2">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000509000.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21845" checksum="A8D1272EE71A8CD9" modified="2015-12-09" version="1">MLLFFLLFLSQISTVVGLNKCYQCASEHMIIYWEKYMPLLNGMSGQASNNCKNDSARHEVVTCEGPCFILNATGLDRKGRTVSYGILRDCQTTYWKKKIEVEGEKTCKIHNKRVNGINIKAEYCFCDHHYCNQNEGSPKNELVSYKRKSKQRHSLVRSSSFKSYQLKFSDLFLIMVFLSIVNLYFSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH00</accession>
    <name>A0A0N5BH00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH00"/>
    <dbReference type="STRING" id="174720.A0A0N5BH00"/>
    <dbReference type="WBParaSite" id="SPAL_0000524900.1">
        <property type="protein sequence ID" value="SPAL_0000524900.1"/>
        <property type="gene ID" value="SPAL_0000524900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000524900.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10626" checksum="80B5518433700240" modified="2015-12-09" version="1">MSQQTFFKDQFRSLLKLVRHHIVKAGKASFVLKILLEAASMRSISERMVTINLNQSYDQLINVKRFKERMKDRKKLLKLLKAMLKRDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH04</accession>
    <name>A0A0N5BH04_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000525200.1">
        <property type="protein sequence ID" value="SPAL_0000525200.1"/>
        <property type="gene ID" value="SPAL_0000525200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000525200.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9404" checksum="8C59170A52B42F41" modified="2015-12-09" version="1">XAQTKAEEHRGMRDAFTALGKHIESMGNELSEHFEDYCKEIPANVEPKKQVKDEEPTKSIRELLIDNYEFDYFNALCCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHK4</accession>
    <name>A0A0N5BHK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000544200.1">
        <property type="protein sequence ID" value="SPAL_0000544200.1"/>
        <property type="gene ID" value="SPAL_0000544200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000544200.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="36278" checksum="E0208B8654CC97E6" modified="2015-12-09" version="1">XVVVLPCINLSDVVLTSKRNTPCSSIMKEYQCLPHSQTRKNYFFVLKKYKLNVCIIGKNFSSMIGAIFCYLFNDKLFLSKHKHLNEDYWDKRICRKELLFRNIGQNSNKSNIKIFKLFKKNWKHFIIIRNPIERFLSAFTHLCVVTMNQISSLRSCYYCKGNMECVVKNLYETLKTYSHNGTRTIFHIKYHFFPQTWLCQYNKHKKHYIKVNYESMNKIKFYSQLIDILRSRNVPENKIEYIKWELYHSKSFHSTNGTTILEKQRKTLFNNPYLLKLLSIIYYDDFIEFEYKLPIYSTNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHT7</accession>
    <name>A0A0N5BHT7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHT7"/>
    <dbReference type="STRING" id="174720.A0A0N5BHT7"/>
    <dbReference type="WBParaSite" id="SPAL_0000552200.1">
        <property type="protein sequence ID" value="SPAL_0000552200.1"/>
        <property type="gene ID" value="SPAL_0000552200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="136"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000552200.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29060" checksum="DD669A0EE573BE5D" modified="2015-12-09" version="1">MGEKKGDVSDKDSVKSRSRSVSRSSRSVSRTSRSTSTSSSRSRSSSSRSSDSSRSSSGRSSSRSSGRSVSRSRSSSRERATSRNRKRSHSRSRSRSPRRSSDRHRYSSRKYSPRRRSPDRRRRSRSRSYTRKNRNKRLVIRDLTQNVTKEHVKEIFENYGTITHIDMVPLKRYDGNMHRGYCFIEYDDPEDALKAVKYMNDGWLDGRRIRVDLSVPRSASKRFNSPPRRRYSSPRRDFGRRRYSRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHY2</accession>
    <name>A0A0N5BHY2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAAX prenyl protease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHY2"/>
    <dbReference type="STRING" id="174720.A0A0N5BHY2"/>
    <dbReference type="WBParaSite" id="SPAL_0000556700.1">
        <property type="protein sequence ID" value="SPAL_0000556700.1"/>
        <property type="gene ID" value="SPAL_0000556700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="11">
        <location>
            <begin position="213"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="11">
        <location>
            <begin position="312"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000556700.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="54706" checksum="F3F7DCE9451391B2" modified="2015-12-09" version="1">MSQALFYGIFAFQWLIYIWETYLSWRQYRVHLLTEKRPKNAEKIMEESEYTKARLYKLDKHRFEFCQSAFSHILNCLILWYEILPLMWNISGDVNKKIGITSEMGQSLMFQTINSLLTFVTALPFSYYDTFIIEQKHGFNKQTLPFFIKDKIKGLVVGLVIMIPVIAAVIWIVENSGEYLFVYAWIFVSIIVFLLMTIYPEFIAPLFDKYTPLPDGELKTKIENLAKSVSYPLTKLYVVQGSKRSSHSNAYMYGFWKNKRIVLFDTLLSAEENEKLKAILAEENKDKKKEGTEEDTLKEEEEEDKDRKNKGMTNDEVVAVLGHELGHWALMHTVINLIVMEVNLFFLFFVFAYFYRWSAIYEAFGFSTQPTIIGLIVVFQFITAPYNELVEFLMIWYTRKMEFQADEYSFNLGYGDLLCTSLIKLGKDNLSLPVDDPLYASFHHSHPSIIHRIERINLLKDKGKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI10</accession>
    <name>A0A0N5BI10_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox protein 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI10"/>
    <dbReference type="WBParaSite" id="SPAL_0000559500.1">
        <property type="protein sequence ID" value="SPAL_0000559500.1"/>
        <property type="gene ID" value="SPAL_0000559500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000559500.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20872" checksum="4D35380237D94E13" modified="2015-12-09" version="1">MSLGKREDENVFRDNSYELHAFKPFRRCYTEMNPSFSGSREKRKFANLSNNNIASMINEPNNEIIINGEKYNHREGRIYTSNVMDNIHNISSSDDLQRNISKVYRRVPIKVLVGFSGGLEKKSYANNLFNYEDKYSKIRKEQVNELESFNNISPKNVPVSRPNINFEKMRASTRKYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI98</accession>
    <name>A0A0N5BI98_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI98"/>
    <dbReference type="STRING" id="174720.A0A0N5BI98"/>
    <dbReference type="WBParaSite" id="SPAL_0000568200.1">
        <property type="protein sequence ID" value="SPAL_0000568200.1"/>
        <property type="gene ID" value="SPAL_0000568200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000568200.1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="120572" checksum="14C031701102C6B0" modified="2015-12-09" version="1">MPEQDIVFKIFNIVKCAALGTIKNSEFASTIKSAIENKTLTRKEMHQICGLIITAFFDEDNYGLKYLNPLESLINLCVISGDIVIGAILKTKFEKLDKKKIGNFFVLFKFVDFLVSKKKPTSSKGNDVMKVAEEILSIFNWYVELSTWDESETFTNYVAKRLFALLQNRYNCILLHATSKKSSECKKLLESRAVVLETKYPEISSYIRENVLIFKSTLERPYSSGLHHDFESISSMMTVYATLRTLESARDIAEAVYMASKNLQFTKIKMLYDMFKGVLYNFANNKTRREGRLFLGFAIIKFPKIIKSLICDLRVLDEIDIVATLAKIATESKLLCIVDFQCKYSFWELFISGLEREGVISESNMEQALYFRSLDYKENKETYENGLYLKPSINFPLNECINAWEYLIKLPLDNLSTVLTGLKHIIEKGGDVFGDSFGDSFGDSFTGILMTMWFKEELGNLSRLFSKINYLCQCKNDSLDDDSKAIRLELFDTTLILLFRIYFHFPDFTIEEFVGLPKKGEESENEESFLFYIWNTRIDKKINIPNDPEERTFEFDWDAPPIALIENPSDDVENELDQIINAISDGENSKNVKKSTEEDEKKVVQENDEKMDDTENLNLVGNDIKRDDINEGGEAKDDKENEGGEKMFEGSEVKIEGLKCASKVENDEEIDSQTRIIVDNLYKDKPFWNDEIDFAEAIKLIPKIAFTLYAIWCFRSMPSLVICLFQCLETGNNTHARNEVLDAIQIVLKKGEFDDKTVYDKWHFVYNIIGKKINDLVKIKAVQQPGTHFLISGFRKTLPVLEYKEIPHPHIIADAMIYTIKHNFVFPEALRIFDHYISVKGITSWCDSCFQELLRLETPDELDLASSLLLSIAFCRPSECFNEITKHIVDSILNADTWYMATHQPGRSALARLLVRSMCCMIWVSENRKHNEIYEKQLSFNEEDPNMNTLEIVFSRFYKETLSGHLKPTISFIIEFIYELAIAPQTPELSRLYSFVSRKFIFNLARLDPYSVTIDLYYRIFNFDDNGDNGLLQFATLHRFKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIH4</accession>
    <name>A0A0N5BIH4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000575800.1">
        <property type="protein sequence ID" value="SPAL_0000575800.1"/>
        <property type="gene ID" value="SPAL_0000575800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000575800.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37894" checksum="5560A640BBB19774" modified="2015-12-09" version="1">MDIPIIDGIFLVFQFFWYILYIMLAICFVFKIISDGKCESDTTSFLYHFVANSVFDIIQSLAIIVFQKFLHWKILVQFFLTSTWIKRVYGPIGYISIIGLILGHLIAVVNRYCALYHCITFRTFWTKKTCLRLIFLQYCIPIVILSHNVFYEAKVVYVPSFDIFIFSLTDKWINIVNSVIFVGISVISAIITATLNIVIFRKYNKVVAKGSGKERSKRLLMLSYMAVTTICLIIFAIEQLVRLYFSIGKKNDGLIIISFTLFWIIPSLTIMQPIMTLIMSKNLRDYFLSFYFKRFLPIKKPASNSTNFRTTVAVTTGKNLKSNQKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIP9</accession>
    <name>A0A0N5BIP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinitis pigmentosa 1-like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000582900.1">
        <property type="protein sequence ID" value="SPAL_0000582900.1"/>
        <property type="gene ID" value="SPAL_0000582900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000582900.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26221" checksum="353798EDB6C28911" modified="2015-12-09" version="1">XATQRRRQKQARVRMRRRQAQRRMRQRQAQRRMRQRQTEMRRRQQERLRLSRTTARPKPPAGRVTISRQKPGSRGSGTGSSSGSGRGPSSESSRRSSSGSGIKSGRERSGSSRPGSRQNEPSEGKSEPESFDEDPQQSEDEGQQEDDGESQQDGESEVSPPEEDESETPDDEQDEEESDATDGEEDEEDEASDGTDDGETEASEKGSEEDQEDTSEPSGGQEEEEEAASPTESNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ42</accession>
    <name>A0A0N5BJ42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ42"/>
    <dbReference type="WBParaSite" id="SPAL_0000596700.1">
        <property type="protein sequence ID" value="SPAL_0000596700.1"/>
        <property type="gene ID" value="SPAL_0000596700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894330" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000596700.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26370" checksum="0815B7487DE817AA" modified="2015-12-09" version="1">MTGIVNFTILLLLYSIIYIVSSLNCMTCNVEDGSNDMDPCIDISQECPEGTNSCSMLVYNSSKSKKVHTRKFCTPIGSDLSNHLLQFPQTGLCQKLNYDSPGINMDINDMIEDTTDNNINFPNPPPLRARRNVLTQHTPSPPSPPSYFNTNILCVCMNALCNAGTLEDVINQKNEISKIEAEAMAVGIDDDLMMAIMNENKFHPNQNIGKIVKKTPEEMVIGKKSQWNFKSFKHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ95</accession>
    <name>A0A0N5BJ95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ95"/>
    <dbReference type="WBParaSite" id="SPAL_0000602200.1">
        <property type="protein sequence ID" value="SPAL_0000602200.1"/>
        <property type="gene ID" value="SPAL_0000602200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894455" evidence="2">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000602200.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14441" checksum="D476CF883EE7E7D0" modified="2015-12-09" version="1">MHFIEHFIILALLTVQYSFQDSSSSSSSSEESQEEVYSPREPTMHKSFYSLPPISARAELIKELEARIREGKERDDKLLEEAREGLDDYRFVIDESRINNEENENNKSAFENSVSLNKKILFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKA4</accession>
    <name>A0A0N5BKA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Invertebrate defensins family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000636400.1">
        <property type="protein sequence ID" value="SPAL_0000636400.1"/>
        <property type="gene ID" value="SPAL_0000636400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894425" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000636400.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9678" checksum="26F1C68A50F7145E" modified="2015-12-09" version="1">MKCFLRLIIFLLFLTRLSREINQNKYAICENLLFSNTDCNEYCSETDHPYGICVRKIFNDVCLCFDKPLPEENDDTITKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKW8</accession>
    <name>A0A0N5BKW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000657100.1">
        <property type="protein sequence ID" value="SPAL_0000657100.1"/>
        <property type="gene ID" value="SPAL_0000657100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894434" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000657100.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8463" checksum="E82D718EA2A803E5" modified="2015-12-09" version="1">MKFIFYYIASIVLFLYTTLTAGAPPVTNTKVIIIKTESNSGRGPMRAPSPKRGRGRSPSPRRGRGPSPKRGFSPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL07</accession>
    <name>A0A0N5BL07_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL07"/>
    <dbReference type="STRING" id="174720.A0A0N5BL07"/>
    <dbReference type="WBParaSite" id="SPAL_0000661000.1">
        <property type="protein sequence ID" value="SPAL_0000661000.1"/>
        <property type="gene ID" value="SPAL_0000661000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000661000.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="83746" checksum="8DC71B6F8EDCA91A" modified="2015-12-09" version="1">MSLTDSNYGSQNNLNSDSVLTVVVRIRPMITNEKIGRQVQIVYPIGVKDLILIDPEKFKNDILRINRQFERQFTFDTVFGPESSNEEVHHSTTENLINLVAQGNNATIFAYGATGAGKTYTMVGTKEKPGLMPLMTSSLYEKIKDTKFTVQISYLEIYNELIKDLLNPSSPILDLLEDDKGNVNIPRLTKMRAINKDKVLQILQNGNQRRTREATAANKESSRSHAILEVSLYNGTKLHGKLYLIDLAGSERASQTQNRGQRLKEGAAINKSLLALGNVINSLSSNSKGRYVNYRDSKLTRLLKDSLDGNCKTCMIANITPCSSYYEETYNTLVYASRALNITTNYVSKQVSSEEQSNIIANIEQAKKDFFQQSGISTNNNSSLPLINNINNNNISQISSDSFNYITNKNTRDKQRKPQLPAWSTTTPINKVDSRKFKTLFNSLKEQYLSISTKQNVLRNELLTINQEAYENEINLVSKSEILKEWTSTNSIEAQKFPKIINKFKQNIGELNKKRSELQDLRHKIEKSIRKNNTTMKGIEQRMRSVMKDKEQEDMINFMVSMAVKDAEKLAITSDSRLLLMRMKRQDYSLKRIYNYEKVTNRLLVEDLDQKDREQLLTEYTLLKNQMKYNLITLKHNENVVSWNTQLLQNTRYNKLPTLRQQQNQKGSSKNSTLPKINEVNIDLPLLKKNSITSDLESSSNISNDSDEKDDGPLSETQTLSKSISSNPLSLPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLQ6</accession>
    <name>A0A0N5BLQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000685200.2">
        <property type="protein sequence ID" value="SPAL_0000685200.2"/>
        <property type="gene ID" value="SPAL_0000685200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="123"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000685200.2"/>
        </source>
    </evidence>
    <sequence length="260" mass="30868" checksum="25D510515E347ADF" modified="2015-12-09" version="1">MTKISSLDNFNAHNKEEQIYRNIYTGKFLTSTPPLVIEEFFIRKRLIYRCNGKTFTSYQMALKYVFNEKMNNPIKYTRRPTSSVLSPLENVNWAKERIYCRKFWLFLWKYCDYNCYSRNNFEVMKQKFLSEINYYREKYGAGKLVESSKLSLYASKYIKEVVQLRSSMDITNFENVGKASLAKAPLIVNHWFGERKNYKFNTLFGSVRTRHFTAMVWKSVKQIGIGIFQEGNEIYVKLIYDKTVNLPNQFEKNVLKKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMB8</accession>
    <name>A0A0N5BMB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BMB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000705900.1">
        <property type="protein sequence ID" value="SPAL_0000705900.1"/>
        <property type="gene ID" value="SPAL_0000705900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000705900.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16774" checksum="548F5A376AA81B32" modified="2015-12-09" version="1">MIRDHINLIRGYHRVETLRENAELDRLAQEHANQMAKQKKLFYVSSTYYGILVWASYYPAASVMVSKWYDERSRYNFLLNSPKPGTQHLTQMLWKNTKSVGIGIARDCDFLYAALYFYPKGNIRGQYRTNVFNKRSNCFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMG8</accession>
    <name>A0A0N5BMG8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMG8"/>
    <dbReference type="WBParaSite" id="SPAL_0000710800.1">
        <property type="protein sequence ID" value="SPAL_0000710800.1"/>
        <property type="gene ID" value="SPAL_0000710800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000710800.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20102" checksum="195F0B9FC0DD1B15" modified="2015-12-09" version="1">MIKDHDVFLFNLAKKVEKIQFHFMNFTNELKTFKSETKDEIRRIHDIMNTNKREPEKKIEDLERKLNLLAYDVIMNYKIMNEHVTVSQSSPVLGSFTDNSMDNDDANEEYNCHPNVSMTMNNFETKEKPNEEDVVEGNVYFEFFLIKLLNKETSPVLFNCENYIQTIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN62</accession>
    <name>A0A0N5BN62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar import and degradation protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN62"/>
    <dbReference type="WBParaSite" id="SPAL_0000734100.2">
        <property type="protein sequence ID" value="SPAL_0000734100.2"/>
        <property type="gene ID" value="SPAL_0000734100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000734100.2"/>
        </source>
    </evidence>
    <sequence length="560" mass="65135" checksum="4B3DAD3CB2F02083" modified="2015-12-09" version="1">MKYYIFADLTVFDESAPGLVDSISNFVNSLKDFRHTTEQVNLADIDGNLSIYFEELSTKCEFNLIEGIFMCSSTSKFLDEIDIKKIPFPSYFLFYDKDDSNKDIKSKTDDVLFLWRKRYFLDNHTLSVQISKNVSGFIECIHNIRNFICQTEDLFLAGHPDFSIWFECTPKIPSYISSILWGVSETVNDRYINSCFDEPPIEEKKSVLDDKSTIEIKSEVMEQDDGKLKDNVKPSNVTNLETFFWKVPETKKESNENIDMFSNPYNSSMNNLHRSKKMNKWDIKNISAVKTKIGDLFEEKQGELVKVKEHFIPLHSKKPFPLYGTDVNCDMHLPELNGLISHHLEIISFGPVNQILNIRVFQPRFELKCKKLTNEDGENKGLSNQTYYDSLGEVLFSKKVVMYFKHVASGEYGFVQATKLFNDEIRMYASFFDYNNKKFVPNGKPIEHAVEHSDRNAVWGTSNVQNYERQCWLTISSFRNECYKIYRFLLNSEKAVKLKNYIKLMREHAKIIGMIDEYNKFLKEMVSSVLPENSNNLPTEHYNLLKSLSTEGVYSPEIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP08</accession>
    <name>A0A0N5BP08_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP08"/>
    <dbReference type="STRING" id="174720.A0A0N5BP08"/>
    <dbReference type="WBParaSite" id="SPAL_0000763600.1">
        <property type="protein sequence ID" value="SPAL_0000763600.1"/>
        <property type="gene ID" value="SPAL_0000763600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="147"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000763600.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48623" checksum="27278ECBFFEE1F00" modified="2015-12-09" version="1">MTCKETSYNIKLTKNVHVSKMSTSNNNGINSFISPFHRRLHDFEEIISRWRSRRHIFSASKTFTIFRRSASIDPKEKESVNRNIVKNPCNCYTSPIPRKTMNLDFSNLSSPEKQDIISSERFNEVRKLVGTLRIGGQEYHNCSPNDLEYISDIGQGAFGRVTKASFKKTKELMAVKHMDLMGTFDEQKRVIMDCYVILTTHTHNHIVNCYGILIDTISVYICMEVMATCLHNLIYQILKGGIPEVYVCKFLVGILDGLYFLKTKNLMHRDVKPSNMLLNWDGIVKLCDFGVAGTLVDSKIVTSIGTGCMLYLAPERVASNPNYDSKADVWSFGISIYEMIKGQTPYEDAHLPFILLNRIKNDPPPKLKNSEASPELIEFLDKCLQKDVHERARYVDLLDHTLIKVFRNKEVDISLWLQDLLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPH0</accession>
    <name>A0A0N5BPH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter ZIP3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPH0"/>
    <dbReference type="STRING" id="174720.A0A0N5BPH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000779500.1">
        <property type="protein sequence ID" value="SPAL_0000779500.1"/>
        <property type="gene ID" value="SPAL_0000779500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF74">
        <property type="entry name" value="ZINC TRANSPORTER ZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000779500.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36119" checksum="ED2F5D66671AB432" modified="2015-12-09" version="1">MNNLLLQSILGFLILIVTIISALAPHTLIKKFKLDNDGKPNLFLSLMCCMGGGVFLATCFLDILPEIQSGYDDIKSRMDIKTNFPFPQLMVCLGFFFVYLLEELCSKYFHKDNETCSHALPNYNSVETSKPLIHENDENRNEKGIQNVSTEIPCSETTTIESPKHEDKKPNDYFKALSFAIIMSFHSILEGVALGTKNDLSGAIVLFTSLSLHKVIEAFAVGLQISRTIPGRSKFAVLVLFFYSIMTPIGALLGAGLKELNIDAISRDVAVLILECLAAGTFVYVTFLEIIAQESAPKDNKMYKLSAVFSGFLIILVIQYQHHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPV0</accession>
    <name>A0A0N5BPV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPV0"/>
    <dbReference type="STRING" id="174720.A0A0N5BPV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000792500.1">
        <property type="protein sequence ID" value="SPAL_0000792500.1"/>
        <property type="gene ID" value="SPAL_0000792500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000792500.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50519" checksum="A73868F18E27C131" modified="2015-12-09" version="1">MAEEPDNNEILGLFDNSTQQPAEESADDQLINALLHNKKSMTLSEQGMKAVSKIFSCKRISHETIESITDRMGVHQDLQFLAPAFSTPYYSKLNMRSVDSNLAKMQDHLLQSVCMLSHNVEAATGDNKSAVLSALINIKYVVDGLSDIRREVAFRNFSPKFNKGLPSVPLDMEEKVTRMDSSERISILPKHAEALFKNVADTPQDLLSFIQRENRKRSYNNTANIEPERYVIINPNMPPNTIHQCLPFWQKIAPTDTVLLDYIVNGVDIGILGEPTQHKIGKNKFSSKEEEQFIENEIKDLLRSNSIKEHDNSKWISPLMVVTTSKMRLVLDLSSLNDYIQHFSFKCESIKDVTDLLEPKAFLTSIDLSAAYHSCAVRPHQTEYLGFKWNNKTYIYLVLPFGASSAPRLFYRITNTLTATIRANGIKMTRFYDDFLITHTDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ49</accession>
    <name>A0A0N5BQ49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Perilipin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ49"/>
    <dbReference type="WBParaSite" id="SPAL_0000802000.1">
        <property type="protein sequence ID" value="SPAL_0000802000.1"/>
        <property type="gene ID" value="SPAL_0000802000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000802000.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44361" checksum="869E0836C1B8038A" modified="2015-12-09" version="1">MTEQVDPINSQEALNAKLLELYNIAINSPIGKYVEASYNSAKTYNPLVESTVTTLEAGIAKAATDYILPTAAKVYDNYSKSVDGTKNALDKTKEAANVSTAYGLTALVAGVQLGLLAGLTSANLALDTAKYTKEMSTNAANYVNECKNSATEVVISTVEKSVEMATIPKNIATEQMNYLLDVTTAYAESLTKKTIPKEDLGENPSIFDRLSVIVKFLAYNVLDKKNLEYFQPLVQNLYGIIDKIKNNFLLLDVFIKEKKWPIGSYKDISEYLLKTKMSIEEQAKKLNISPEQLLMEQIRQNTEKLDKSTEEIKLKGENLLTPQINDFLSKIITSIRNFDNSITTSKSVFDVHDEVIQKIIHLLSTALTFSGLKESDKENDDEKNDEKEVDKSDVSTNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQA4</accession>
    <name>A0A0N5BQA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000807400.1">
        <property type="protein sequence ID" value="SPAL_0000807400.1"/>
        <property type="gene ID" value="SPAL_0000807400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894699" evidence="2">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000807400.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="27935" checksum="BBD50D37770CC406" modified="2015-12-09" version="1">MHVQSILATAALAASANGFLFGAGGCGAPNPCGGLQLPRFELPRIELPRFELPQLGGCGAPACPPPAPACGGSPCGGQGYAAPPPPAPQGYAQPPVAGGYAGPAVGGYQQGPIGGGYAAPAVGGFQGQAAGGYAAPAVGGFQQQGGYQQAPAAPVAGGYQQGPAVGGFQQQQGGYQQAPAAPVAGGSYQQGPAGGNYQQAPVITQVQTEVAKVEQVAPVEPVAPVAVVEEAAPAAPAPVQVQQQAYGDNAATQTGSVQVVETKEDVVVAQPEPVAATGSAPGYRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRZ4</accession>
    <name>A0A0N5BRZ4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRZ4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRZ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000864000.1">
        <property type="protein sequence ID" value="SPAL_0000864000.1"/>
        <property type="gene ID" value="SPAL_0000864000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.20">
        <property type="entry name" value="tRNA intron endonuclease, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000864000.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28823" checksum="E586A48AD4AFFF16" modified="2015-12-09" version="1">MSYKKRSFNPRFRQWKFKPTMLCSGYLSENGVIIKDSYAIDHLTFNGSYGKFIGQRMNFQTLSCFSNEESLLEYNNIVNNCQNLYLSFVEAFYLAYSLELLTIYCSEKDKLTIDQFWKICVDFNDKFLVDYAVYKFFKDRYWVVRSGLNFGCKYILYKNSPEVCHGNAAVYIMSKCYFDESDFDTIASRAQQRLLSNVKKDLIYCYIKFIKDEFNVYEKESLEFIKVTMKGKKARNADRPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS56</accession>
    <name>A0A0N5BS56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS56"/>
    <dbReference type="WBParaSite" id="SPAL_0000870150.1">
        <property type="protein sequence ID" value="SPAL_0000870150.1"/>
        <property type="gene ID" value="SPAL_0000870150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000870150.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36089" checksum="71153C998A19CB5A" modified="2015-12-09" version="1">MLSQPTSRIYTLLPYAILALFGLITTVYALYKIIKIQKFQSPFGLLLKALFLNVILYLVTILFWLSIRILFDVNSLMENYSRYVGIFFIFTWYFSEFITVAISSNRFIAIAFPIYYRNEITIDKTKIIVGVISTVTLCLTISSLIGKNIYKILISIIIESCSMNYNIKTLTWSFPNSWCGKLYAFWFQFIGGIVIIIISLIIDTSTLLSLIHRKQHSTVFKTNVKKHISIVRQDVLFFCQSFLQNIKTLLIVVSINVFTRLIDSIYGKFYFRTFSWCLCHVLDVIIIILFNKELWRINKCRPISQVTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSM2</accession>
    <name>A0A0N5BSM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P4Hc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSM2"/>
    <dbReference type="STRING" id="174720.A0A0N5BSM2"/>
    <dbReference type="WBParaSite" id="SPAL_0000886400.1">
        <property type="protein sequence ID" value="SPAL_0000886400.1"/>
        <property type="gene ID" value="SPAL_0000886400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000886400.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="63059" checksum="2F22CF1535120006" modified="2015-12-09" version="1">MEQNKNFKINSVYLENIVPLEKGNKPFPIKICKDFVENEEELKEFVKSLREVKFSIKNNDLYCLKQTVDLSEIPNKENKPIIKNFVKFIKEDVKEYIKKVTGFELTDKVTLTGSSYKKGDYLLPHNDQVSNRKVAFILYLNDKDKIIEGGKLNLFDVDENEFPMNVVYTEAPEFNKLSFFEVSNKSWHEVEEILNDGVERLSVNGWFHVKEDNNIVRKDVPEPIKEIIKEDFDLSLFLSSKMLDDKYMTVIKKRFEEDSYVALSDFLKKDVLDNINKELKQVKFKREGPWHKKNIMAFDESQLPEESTLKKFLICSRSDTFMKYFSYITGLHFVDIPGAVTSYDGIEEEEDKNNIEDSLPIKKPKLDVAEENVSSTETKKEEITMSHKFYRISKKCYICGDDQIAEKAIQHGWSLDVKFFFTDTEWDNKTFGGYTSYITPYNEEEIFRIEPLNNVCFLVFKEPNCFDITKYVQNCCGDNYMNCLSISYMGLNNDCEGEEESLDEEIYLDEELEDEENIENQSHGHEDASNAHEDTDNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BST9</accession>
    <name>A0A0N5BST9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spc7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BST9"/>
    <dbReference type="STRING" id="174720.A0A0N5BST9"/>
    <dbReference type="WBParaSite" id="SPAL_0000893100.1">
        <property type="protein sequence ID" value="SPAL_0000893100.1"/>
        <property type="gene ID" value="SPAL_0000893100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000893100.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="93913" checksum="874A7F8131AD78FC" modified="2015-12-09" version="1">MSDRTNSILKQANDGSSSSLETPKNTVKRRVSFSTKRVVQRFDKTDITIRFDTLTEEDIDRSGSSGSLNSTTTPMSTSRPASVCMTPVTPVPEGLNTTFDVFGMSPGNISVASNRTVRTPAMNTTRNVFAPFDTSTPRIEILNDSETNDDMEISFARTPMKPSAGKSNVEAVNKSLVNMSVTSPEGLTPIKVNNTVMEESNYSISRDASNAHQSIINSVKSSNSYRILSNSYIYRNSPVLVSGESDSGSQDRPNNVTPFRRRSSSSGRPSRNNSLRRSLLKNMSFSVECVPTTPGREDLSNAFDVDKINESSCSQSFIKLASPARTCEAPPFTPISPVADGFINDNSLINASVLGAGVKEKEMEVDMTHASSPDSAQRFLNDSYDFVYEDVLNVNSSTDDTFKNSTALKDTSTNSNALKGVTTNSTALKDVTTNLTALKDAIQNSTTFNEKSQTSFNDSKNVGTSKDTTLPGSFCEKSFNALDGDSSSLSVKCSEKAALQENHSKTLEKVTNIHFDKSGYSKDITIVEKHCETLHPIVEEEETQLFDKTINIDEVMARSEELKNAYSNQLNMLESTDITSKDNESDIFNETSGFSTDTDTSIWNRSDSVSRSNMVDDKSERAATPLLNEEMETDGPNNFSTMDVTMRTIGESFINSELYDATRMAEGLDFINPISSVVYNDNYKECDEYYQLRLAVAFIQSILYNYSLSQPMLKDFVHGFEKAAELKNFMIKTETPLDLDDLYDKVLDFKDIGGIIDDFRQINFDVYKTAADQLEVFFDTVYEIYFLLLDHLSVLQQKQIEHNDKVCYECFGIFNEIGSVKKLDNEERKSLSDLLNYIVPKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSY9</accession>
    <name>A0A0N5BSY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BSY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000898100.1">
        <property type="protein sequence ID" value="SPAL_0000898100.1"/>
        <property type="gene ID" value="SPAL_0000898100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="249"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000898100.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="62027" checksum="EFD204889E38AD1B" modified="2015-12-09" version="1">MDNFETETEEIGNCFDLSSISSKDNGTIITNLASKRLNKSLIFIKSNPSSNILKETRGYSYVADKNNLNSNTESSYYCRSCRTLYDRWAYKNKKRGLPTTKIISHVYLDKEMKLFKKTKHHPECTGEITVSQLIIEQLLIKYYKIAELRMVNCFDVHLQFINEASEIAYINNNSPFDITTEISFPTYRQFAGSVKYHKKRRGFEDIKNRPELLLTLDRREFVRYISNEMIVMMSPQGEQILRNCDYMASDGTFCKSSSEHYQLYSFQCRNPQSTKFFPSCFVLLNGKRESLYKQMFEVIKSLVCTSCDWSKKILFLDKELAACKAAKEVLKCTVKLCVFHTISCFQRALKKGGLQNFYTIKKKYKLRNQDSTTHATLYSNIQKIYCLPYFPPEEAILYWRRYIKPGFLKVTGSIGKKIKEFVTYMDTRWFMSYSGYSPSMMSIYSLDVTTTNSCEGFHSKLKRCLIMTKKGKVVDVIEGLKMMELRISSEYLREGLYGGEGEKSIKNKAFYQLYCCFQFNEKNLDEYAAEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU18</accession>
    <name>A0A0N5BU18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU18"/>
    <dbReference type="WBParaSite" id="SPAL_0000934200.1">
        <property type="protein sequence ID" value="SPAL_0000934200.1"/>
        <property type="gene ID" value="SPAL_0000934200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000934200.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8312" checksum="A01C98942D9D070E" modified="2015-12-09" version="1">MPTKQNQGSFTGHPMANNMAPPMPSFGTVIRQGLENGNIVGVEHRVRWLFQKGDEGKVNMMQNNSFKKNPKNAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV18</accession>
    <name>A0A0N5BV18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV18"/>
    <dbReference type="WBParaSite" id="SPAL_0000968600.1">
        <property type="protein sequence ID" value="SPAL_0000968600.1"/>
        <property type="gene ID" value="SPAL_0000968600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894892" evidence="5">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000968600.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17439" checksum="9866BBA27EA78666" modified="2015-12-09" version="1">MHWKNFIIFLFLNLSTNIYLIESLESLFTRSVQTVGIKGVFLCNGKPLEHVVLELYEKDTFSFDDLLNRASTDLMGRITFYGSEKEFSTIRPLLKVGHFCNIKGRNMKQIDYNVPQIYVNIGDVPLKYCDLGVVDLSKDTTLQCKSNNSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV47</accession>
    <name>A0A0N5BV47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BV47"/>
    <dbReference type="WBParaSite" id="SPAL_0000971300.1">
        <property type="protein sequence ID" value="SPAL_0000971300.1"/>
        <property type="gene ID" value="SPAL_0000971300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF141">
        <property type="entry name" value="TRYPSIN-LIKE PROTEASE TRY-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000971300.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25057" checksum="1336A5AAA779E873" modified="2015-12-09" version="1">XKNIVYATEIVIGNYCNENEDVDGECINKGKVQTRKINRLLYNFKNGHRKQRNDIVVIELDTPVIGVIHICLPFLHDKYKFNKRKTLITFGYGTTRRGRGVVDAKFHNRLKRFIYSNPDSVRNCTPPYVPINSTEYLCADVNVHLGLCPGDSGGGLMQKTSDNRYILVGVNSITVSCIYMELTDLDFEKPNIFVQVEEYKDEILNFMHETKSYYSENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVZ5</accession>
    <name>A0A0N5BVZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIBOSOMAL_L9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVZ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BVZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001000100.1">
        <property type="protein sequence ID" value="SPAL_0001000100.1"/>
        <property type="gene ID" value="SPAL_0001000100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001000100.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15008" checksum="0165BA8BB3F8BC1C" modified="2015-12-09" version="1">MNSKLVLSPVRNLNFTSVRSLLRPVANTPYYGLYRKDGETVLKDDLLVVQKKLNWHPGRNVYVQKDRHICMLKSNVDGKLLFSREKVELDMSIPDVEKAYSGKFTEDLYKLTVNVVPFEESNTFVLKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWE4</accession>
    <name>A0A0N5BWE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M-phase phosphoprotein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWE4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWE4"/>
    <dbReference type="WBParaSite" id="SPAL_0001014100.1">
        <property type="protein sequence ID" value="SPAL_0001014100.1"/>
        <property type="gene ID" value="SPAL_0001014100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001014100.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19734" checksum="3CF2AB9480A8A6BA" modified="2015-12-09" version="1">MKPKSEERQHFFEKTVSRGVLDMKFMKRTKNKVADFKEKQKINIISDNVINKFRDNISLSGSSKVMYTSGNNVIKSEKSAKNISYIFEDSYMKLQDLSFGRKSFKGFNQEVEKLMLFHENLKNGNKEEEDFEHMEKKDVNDKEFINVMGSNKMKRKLNIRENRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX92</accession>
    <name>A0A0N5BX92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX92"/>
    <dbReference type="STRING" id="174720.A0A0N5BX92"/>
    <dbReference type="WBParaSite" id="SPAL_0001042500.1">
        <property type="protein sequence ID" value="SPAL_0001042500.1"/>
        <property type="gene ID" value="SPAL_0001042500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001042500.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16343" checksum="200DC2BCB8F5B3F2" modified="2015-12-09" version="1">MSIQSEQEKIIQKFKLLREEVMIIKREYAKAVQEMKDHKKIFNELKNMDPSRRSYRIAGAHLLESDVGTVRNYLEENIARFEILTKQLEEKLNAKLTEHDNYVQEHNIRVVSEEEAKQLQMQQLASQQQKSASKGLKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYA8</accession>
    <name>A0A0N5BYA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYA8"/>
    <dbReference type="WBParaSite" id="SPAL_0001076900.1">
        <property type="protein sequence ID" value="SPAL_0001076900.1"/>
        <property type="gene ID" value="SPAL_0001076900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895113" evidence="2">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001076900.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22738" checksum="7985489BAD88A688" modified="2015-12-09" version="1">MNIKYFLVILCIVLLITFDLAEAGKKVGKKGKESKAVEGKGKKSEKVKEPKVKAEKTKVEKVKGKKVKKSKKTEKVVEEKVVEEPKVEEVVEEVHAEAEVVDKHLEEAPVRDEIPTKVSTLQEKIAAAKAAKQAKASSAYEQCKQECRAKRDQLTAQEYVDKLKQELADAQEYLASQPIPETQAAPVTPETTTDVPVLSKTRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYL2</accession>
    <name>A0A0N5BYL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BYL2"/>
    <dbReference type="WBParaSite" id="SPAL_0001086400.1">
        <property type="protein sequence ID" value="SPAL_0001086400.1"/>
        <property type="gene ID" value="SPAL_0001086400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001086400.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61680" checksum="800271EB9B2304AD" modified="2015-12-09" version="1">MLRINKDMYHHLFYKQIFLLLYILSSNVNFVKCTTSLTSSESGSGSIFDLNHPFSSRNIIQDISNKDTEVTFTKIFGKGEPPIVSHHTARNIKFIKSSDNKLHNAIISSFTIKCCDGSYPMPLNSSVQQNFTFSEADYEIEELDLQPLFAKEENTETYCKLFNGNFTILEKYTKQPRLLDLYNATCKCQSQKYYPEIILDSSCRQLPKCLNNGYRSFHSNNKCKCPQPYFGYLCEKKCEKGSLYKDHFGIDICSCHPYYQGSECSEIICLNGGSRIHDKCACLNQFLGYHCEIDTNSTIINPRMTKYSDSSSDIFSRDVSGTIFSLVMIIVLVISMYLLMKHRMQSQNRYIPRRPDLLGGYILSIGGSSNCSAAPGIHGNSQRRTMHPIEGCRGYQFRNMVPVEGPPAYYSHDQRRVRRGEILPPLPSYEDATKLPPLKHGGINMEVTNEIDDTPVLISEINENQEPSSTSLLCNSDLPISTEINEEIESVISKSLSLDNEPEDLQNVNKCNNTSMDGKNYQDSDSGSLLSQQNNDSKKITSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ13</accession>
    <name>A0A0N5BZ13_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-beta-N-acetylmuramidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ13"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ13"/>
    <dbReference type="WBParaSite" id="SPAL_0001100900.1">
        <property type="protein sequence ID" value="SPAL_0001100900.1"/>
        <property type="gene ID" value="SPAL_0001100900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16890">
        <property type="entry name" value="lyz_i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000023">
        <property type="entry name" value="Invertebrate-type lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF13">
        <property type="entry name" value="INVERTEBRATE-TYPE LYSOZYME 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895068" description="lysozyme" evidence="12">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="25"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="76"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001100900.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18607" checksum="372C06581FD7A1A6" modified="2015-12-09" version="1">MLLKFLLSTLLLRLPYFDRCFYCICLHESGCRPIGCNPDRGSLSCGYYQIKLPYYKDCGEPDKRPGESTENAWKRCSDDYACATTCVENYFNRYRYKCPGKSDCEAMARLHNGGPNGCQSSSTDGYWNTVRKKLVTNILLTIFINDNNNNSFFQIKRCFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZM8</accession>
    <name>A0A0N5BZM8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZM8"/>
    <dbReference type="WBParaSite" id="SPAL_0001121900.1">
        <property type="protein sequence ID" value="SPAL_0001121900.1"/>
        <property type="gene ID" value="SPAL_0001121900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001121900.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18795" checksum="AB225E1C222C8E30" modified="2015-12-09" version="1">MSSGDPGSRIKSLKDYNGRTRYSIYLLNQLNRLKVPVEDHVNHFLSYQDEDTVDAFYEYHSDYTLATWTDVEEFCEKRQPHTVKPFILRVTEVMEARRLPDELPNSYYNRLLSILAFGDMKEATTLVTLKLLNELPLQVKEHFSDRSSEIDLSLALGTLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C067</accession>
    <name>A0A0N5C067_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C067"/>
    <dbReference type="WBParaSite" id="SPAL_0001139800.1">
        <property type="protein sequence ID" value="SPAL_0001139800.1"/>
        <property type="gene ID" value="SPAL_0001139800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001139800.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19727" checksum="FD9C35269DC84C17" modified="2015-12-09" version="1">MALFARRFSTSFLILLSFFILYQIMVTASKDIHFYNFRNVNTTTDNSIKDTLQPHQIAIVTVIDGAVEYMYKQAIETVKCYSWHHNYTLAILNTQELPEFTYNCNQPEFFFRRHCIVANYAQRYKNEIKYIIIIDADIMVVNPVHRIENYLPKGEEDILFSDRIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Q2</accession>
    <name>A0A0N5C0Q2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nanos-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Q2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0Q2"/>
    <dbReference type="WBParaSite" id="SPAL_0001158000.1">
        <property type="protein sequence ID" value="SPAL_0001158000.1"/>
        <property type="gene ID" value="SPAL_0001158000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="9">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001158000.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22581" checksum="9664F42AA6D62BE5" modified="2015-12-09" version="1">MCFTKRSSRNESKLPNIVQHDPIAIKHYNEHYSPLDCKTCFSIEIYTEKLDIAIRQYSLISRDPFSGESNDEVKNLYELPLEDLFNIAGKMPWDRDMKINRIADFYNQEYQKNKKNVVTFCSFCYNKALKESEKNGETLDMYGGNCPWKSHNIKNVKGIVTCPYLRNLSCSNCGATGDNAHTKKYCPHPILVMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0S8</accession>
    <name>A0A0N5C0S8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0S8"/>
    <dbReference type="STRING" id="174720.A0A0N5C0S8"/>
    <dbReference type="WBParaSite" id="SPAL_0001160500.1">
        <property type="protein sequence ID" value="SPAL_0001160500.1"/>
        <property type="gene ID" value="SPAL_0001160500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895158" evidence="4">
        <location>
            <begin position="20"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001160500.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="57733" checksum="DD9CA5EA3EE5AAF0" modified="2015-12-09" version="1">MKLLLTLFSIPLIFLPVESVTRCGGNEVLNQCGSLCELKCGDSENKACPLVCGPPACQCAPGFRRHPTNGQCVRPNQCPANSQPNRCGRNEVLDQCGAACELDCGDSENKACPLVCGPPACKCAPGFRRHPTNGQCVRPLECPVVFDPPSSCRMNEVVVQCPPRCEPSCNNLNASCPPVCGKPGCVCAPGYVRAPKSGDCILKSQCFPSTPSPVTCQRNEVFLQCSSPCEATCEDQNPTCVRRCDEPKCQCNTGFVRDTRTGACISPSQCRRSTPKPVTCQRNEVFLQCSSPCEPTCEDQNPTCVRRCDEPKCQCSTGFVRDTRTGACISPSQCRRSTPKPVTCQRNEVFLQCSSPCEPTCEDQNPPCVKRCDEPKCQCSTGFVRNTRTGECVLPSQCRRSTRSPATCQRNETFLQCSSPCEATCEDQNPTCIEKCDEPKCQCSTGFVRDTKTGACISPSKCSRNPPGIVKCPTNEIYTICSSLCEPSCDDRRPICGRSCERPKCECVSGLLRDKSTGRCVEESRCPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1M7</accession>
    <name>A0A0N5C1M7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fam-b protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1M7"/>
    <dbReference type="WBParaSite" id="SPAL_0001190100.1">
        <property type="protein sequence ID" value="SPAL_0001190100.1"/>
        <property type="gene ID" value="SPAL_0001190100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895205" evidence="2">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001190100.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29454" checksum="4BFBE04903A7946A" modified="2015-12-09" version="1">MMDKLLISLLLLLNCISFSHSTTNPTKNIINDVLKGIDTATIGPEMTKFFEQLEGLGEFYNQPLVMGDNNEYEMKKSMVADRIRKNTNMIKHLVNENEKNLMPFLTQDFNKSPKPNKADVYKAQWNGEDFLTQKFAKYISDSKSLKDSRKPMSREKNHFYTKDMTTEHTNNNERKTIIISHERDTQSNVKDFLKKAIDELVKLFKGEYRKSDFDQISEEKAAKKVAELYRIHQLKMKLKELEKELQEEKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1S7</accession>
    <name>A0A0N5C1S7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUEL-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1S7"/>
    <dbReference type="WBParaSite" id="SPAL_0001194700.1">
        <property type="protein sequence ID" value="SPAL_0001194700.1"/>
        <property type="gene ID" value="SPAL_0001194700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001194700.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14297" checksum="D50651C277073D65" modified="2015-12-09" version="1">MRVFNTSVIFIIISISKYFGSASYAKYFVILHPKCYCPEENIKMEMKNHQMPNKYFEKKDGSCNDLHGLQACCVPSYSHKQQYVEITHTCGEEKIIRMYLDDQCEFINDTDNIYSYHCYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2F0</accession>
    <name>A0A0N5C2F0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein of centriole 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2F0"/>
    <dbReference type="STRING" id="174720.A0A0N5C2F0"/>
    <dbReference type="WBParaSite" id="SPAL_0001216000.1">
        <property type="protein sequence ID" value="SPAL_0001216000.1"/>
        <property type="gene ID" value="SPAL_0001216000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001216000.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41740" checksum="43F0531897DA2EE7" modified="2015-12-09" version="1">MAFSVNSNKLLEGLNNMTTASLLIKKQAECQIKAFNCLSKWAANNDNAAIKDVVIKSNDIFKIFGDKLIQLASEQEAFIKELKKIEQTETSIKCAEKKLERSLEKEKKYEKEIKKYSRSSSSSFFKTKKQTDLGLLNHDLKTAKHATYNARKELSNIRAEMEVVKMFRFRKGMERMCVAWRNFSNDISSIFTCQQELIEMVPAVSTEDVREMLYEEAYLTKSIVDDLKKKLNYHDDIGDVNRVEKEDSTREIPYLIKNDEALIRSSSTTVSSDFENKLLRICTNPEKLSYDSDYSSSKSLEICTQKSGKSPIATHDKEGSYENLYPLLPPNPYKNDKEFGGKNYILSNSNNSAIMDTFLIRQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3G9</accession>
    <name>A0A0N5C3G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3G9"/>
    <dbReference type="WBParaSite" id="SPAL_0001251700.1">
        <property type="protein sequence ID" value="SPAL_0001251700.1"/>
        <property type="gene ID" value="SPAL_0001251700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001251700.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36873" checksum="5424AC4482C6CC83" modified="2015-12-09" version="1">MPYTKRATLSPDLYFKSLAFITIGVIAISCIMTIYQINIPFPTIFQWICTSLGEITFLKKSLHNFKIYTGYATEKIQLFDSDNHSHQTFDEETFEIKYNEGLPVLTKEQLNLFDGSRPSKPTCLAILGRIYDVSRGSKHYSPGGAYHSLAGKDATRAFVTGDFTEEGLVDHLDGLSDQDLLGIYDWIKFYEREYKLVGYLQGTYYNSNGELTEEGEKSKLRLEKALHFRSTQVEEYEVFPPCNSEFHQSSGGRVWCSNRSGGIKRDWVGVPRKLFQPSSKSFRCACVKNFGDPLSTPGVKGNRGDLDYPNLGEYESCSSTSNSCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3U4</accession>
    <name>A0A0N5C3U4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3U4"/>
    <dbReference type="WBParaSite" id="SPAL_0001263000.1">
        <property type="protein sequence ID" value="SPAL_0001263000.1"/>
        <property type="gene ID" value="SPAL_0001263000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895359" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001263000.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26386" checksum="F098C116F225A80F" modified="2015-12-09" version="1">MNLIRLIKFFLIPATLTLSKPHNKVCGLPDNISIYPNYIIEELQVIWKNYVPSSNCDTKYLLTQNVLRLHNDIIDHLSEQNEVASIDTATPSYIIPAKTPQAFGSKSMAIVEKPDYHTQPEQSYFFSNSGNFDSKGPTSPIATTGEDAPGPYLNTEQATFLRNVTPQIRDMFLRLFYDPDIPSESLRDHKLHMLAVSMLDEETLKLFDNWAVNRRKALKDISSSIPKKKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C453</accession>
    <name>A0A0N5C453_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C453"/>
    <dbReference type="STRING" id="174720.A0A0N5C453"/>
    <dbReference type="WBParaSite" id="SPAL_0001273800.1">
        <property type="protein sequence ID" value="SPAL_0001273800.1"/>
        <property type="gene ID" value="SPAL_0001273800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001273800.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34644" checksum="F2980931CB4A6D2E" modified="2015-12-09" version="1">MLSSPLLLSLSSVCALLGLSFLVIAILSDDWTEHKVSRSTIIGAMNRQPELSENLKDAVSHNSLYYSRSNGLFHICFPDDVPSGIGSYSKFGSICITNNDYFPDSVIRENFNDKQVERLYFMRTTVVLYGIGLICIAFCFIIGFFGCWKRSPKYIMTTAILMILSVLFLSAAMISWHYVLYLERNVLDVQPYYKAWEPVLKQATKFSIGWSYLVSWVGIGFVLFAGIFMLCSHKAMKNEDEKAFESKHNAYMMANYYDKATMVPYGYGTYSGYGGSAAFPAAYYNTYIPQIAPPINNHYGYMSYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C454</accession>
    <name>A0A0N5C454_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glyco_transf_64 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C454"/>
    <dbReference type="STRING" id="174720.A0A0N5C454"/>
    <dbReference type="WBParaSite" id="SPAL_0001273900.1">
        <property type="protein sequence ID" value="SPAL_0001273900.1"/>
        <property type="gene ID" value="SPAL_0001273900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF4">
        <property type="entry name" value="EXOSTOSIN LIKE GLYCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="10">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="11">
        <location>
            <begin position="443"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001273900.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="81688" checksum="69D736BB09977A31" modified="2015-12-09" version="1">MIQPFPLKKCLFLLKTILLIIPFILLIKLVNHDENSSINPLLRKSKLTKGNESNWKWGDRCFIQSENNRILNSIQKELIETSKNLEKVNKDIEILDKILLSKKEELDILEQQIEEAKLLQKELNDRRNVKISLPLKPLYPDYNRLIFKEKKLQNDFDTIEKVFDFSRCSISKKLKQSAIVSEDSVLIDYNCAFYNEEWGKYGLCGDRNFRLDVLKRSVFTLIFPDPESYSFRIEEALLSGSIPVILSMTNPLPFDDVIDWRTAAIRVPFNRFPELHFILKSINLADILEYRRKGRFYLENYLKSPSLIIGTIISSLRYRTLSLGLPSLEVKAKPLFGDSFVSLSQSPVPKPQIEEEYLGPIEASFDSPSYTHNFTSLSMYSYELWNNFPHLVHFTPSYLINHAIMPSESEFYEDTNSGFRPISPGSGVEFSKALGGNRNREQFTVVILTYNRDQILYSSLERLHQMPYLNKIIVVWNNVNRKPQNNWPHLHVPIVFINVTKNSLNNRFYPFDQIETEAVFSMDDDIDIKQHEIIFAFRVWREQRHKIIGFPARHHARYGDKMFYNSNHTCQLSMILTGASFIHKSYLIAYTYTMPKEIRDKVDEFMNCEDIAMNFLVSHLTRQPPVKTTSKWTLRCPNCPETLSSDESHFNERHECIRFFTQIYGYNPLLFTQFRVDSVLFKTRLPQNHQKCFRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C469</accession>
    <name>A0A0N5C469_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C469"/>
    <dbReference type="STRING" id="174720.A0A0N5C469"/>
    <dbReference type="WBParaSite" id="SPAL_0001275300.1">
        <property type="protein sequence ID" value="SPAL_0001275300.1"/>
        <property type="gene ID" value="SPAL_0001275300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001275300.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28253" checksum="9F3CBAE36CB6B46D" modified="2015-12-09" version="1">MHKILDIRRFSSFVDKNEVANFAKLGGVWMDENNEFKALHSLNKFRVPAILKSVNSSNLKDKNILEIGSGGGILSFSLARLGASVTGVDACKESVLSAKTSAEQILNDKIRKRVNFIHDTVEEFSKVNRNKYDIVIASEVIEHVPNVEDFVNKCGSCLKDNGLIFFSTINKTFLSKLLAIKMAEDILGIVPQGVHDWNKFVSPNYLTEVLNNNNISVILCSGIGYNPLSNNWFWINNTDVNYFLIGKKNYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C476</accession>
    <name>A0A0N5C476_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C476"/>
    <dbReference type="STRING" id="174720.A0A0N5C476"/>
    <dbReference type="WBParaSite" id="SPAL_0001276000.1">
        <property type="protein sequence ID" value="SPAL_0001276000.1"/>
        <property type="gene ID" value="SPAL_0001276000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="123"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="316"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001276000.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="70986" checksum="10BB0E461CDD62DF" modified="2015-12-09" version="1">MFNLRSIKKLENINNKIWKRNIKLTNKNNSNETKDNSDPYRKELKRFYAQETVTTTKRGIDVLLNRKLNKGTAFTLFERQYLGIHGLLPAAFMNIDQQVYRVMSEIRSYSSSMLKYEALMGLAERNEKLFYKVLCNNIKELLPIVYTPTVGEACLNFGKYFKTPRGLYITINDNSISKINQILSNWPENNIKAIVVTDGERILGLGDLGAYGMGIPVGKRILYTALAGITPCECLPVLIDVGTNNEKLLEDPLYIGLRKKRVGGEEYDRLLDNFMKACVKKYGQNVLIQFEDFGNKNAYRLLDKYKDKYTIFNDDIQGTASIILAGLLATTKITNKKLSDQKFFFFGAGGAATGIAEMVVSHMVHEGTPFHSACDKIFMFDVNGLITKDRIPQLSRRLVHFAKDLPNQKNLYESICMIKPNVLVGAATVKGAFTPKIIKKMSEVNERPIIFALSNPTSKSECTNEDAVKLSNGKVIFGSGSPYKPVLYNGSYYKTAQANNAYIFPGIALAATLFKIKHINEKHFLIAAKEVANYVSQERLDRGLIYPSMEDVKEISIKIALKISEACYKDSTACLYPEPSDKELYIRSKVYSPEYGDIIYRTYDWPKEDTVQGYKIPKLSDRTSYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5P0</accession>
    <name>A0A0N5C5P0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5P0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5P0"/>
    <dbReference type="WBParaSite" id="SPAL_0001326700.1">
        <property type="protein sequence ID" value="SPAL_0001326700.1"/>
        <property type="gene ID" value="SPAL_0001326700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
        <property type="term" value="P:epidermis morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="395"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="9">
        <location>
            <begin position="603"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001326700.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="79649" checksum="3A3270F2E0C08668" modified="2015-12-09" version="1">MSEEKGLSKRKIKQYKVKSKTMDFFGSVLAPLRNNSVKELSNTLSGSSKGKLMAIQAPSNTSTQNCLVIHEKPLKQLKKSNTVVFEDNSMKSSSKKSPYDEINSDSSKNSIIFKMRSSLKKSKHEHCNSSYVSLKDYSEPNLNPDIFVSNIENKKSSDKSSLTSKINIFKLFSNTSKKKDSFDERKVRKTKSYNCRMGSLNFTDTQSSHFSVCVKKEGNTNDEKNVFNNVYNTIDSHAIKKVNSKDRSLVNEKDGTLLVDSKIATTLPQINVNGNSSSGGENNVVRVKLRQPKRYYGSHTTSKFIDCYNEDVPDAPPRRKMIGFLHRTSNFSVDSTYSDDSVTRHSLENKLLLDSEVKEKNNRLSKRTEYVTPSVSTKQQFSHRDRSLRYHRNINVVLNMKVNDFLGINLVGHSSRNGDKGIFIADIIPGGAISQCGRICVGDEILEMNGISFENVSNDQAVIMLTNEMKKREMLRLKIRKHYNSILEYHNYDKTNLSNKSHFNFVRRSLRDYPNHFNFSQPINDDIWMPQKINKNDENKVELPQILMPAIRESHENLPSSPGIGKKSLVNQNDRKELTMHHVDKLFDLDTNKENVVLSMSLPNSYLEAKEKAWIKINYPMCFHGKHLIDWLLANVKGLKDRKSARNYAFELLKEKLIVHVICRYTFSEQCYYVFGEKIEKLKKADECGIDRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5X3</accession>
    <name>A0A0N5C5X3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1691 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5X3"/>
    <dbReference type="WBParaSite" id="SPAL_0001334900.1">
        <property type="protein sequence ID" value="SPAL_0001334900.1"/>
        <property type="gene ID" value="SPAL_0001334900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057591">
        <property type="entry name" value="TMEM126-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23408">
        <property type="entry name" value="TMEM126_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001334900.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32321" checksum="B9E5A6F160DDE314" modified="2015-12-09" version="1">MFDPSKYWEESVKSSDKKDSNIKALVGDDLGSGRSKLWTKLSMLSPAEQSGYMSNLIQYWPVAIERRAFHWPHFSLAFSSAVTTTLIATKISGDFFLFSNKASLIEVMNRAPKIPLYAGIYVSGVTTYLLNHVLVYKDLYQDNEVCPSCILTKCIGNEVLAGVVVPMVSVPLMGHYVMLNKKDMKVPEVKNFVDLIGLSLEGIKSCRRIIPLVVGIQILSGIVGTYSILWGRNKIFSTIEMDEEYVDIAAKEADKVKPLKERFLDFLQKIPLVSSIMEFENQRTKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Y2</accession>
    <name>A0A0N5C5Y2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0001335725.1">
        <property type="protein sequence ID" value="SPAL_0001335725.1"/>
        <property type="gene ID" value="SPAL_0001335725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895422" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001335725.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10127" checksum="A97307016AC41A5B" modified="2015-12-09" version="1">MVFLRALTIFIISISISKIIISISETVENKNNTSKVNVYVWGYLNCTQCGPNDVLIDLLENGKSRNITTGTCTKNFEFDIWTENSTSLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C649</accession>
    <name>A0A0N5C649_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C649"/>
    <dbReference type="WBParaSite" id="SPAL_0001342400.2">
        <property type="protein sequence ID" value="SPAL_0001342400.2"/>
        <property type="gene ID" value="SPAL_0001342400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000104">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055928">
        <property type="entry name" value="Fmi-1_DUF7505"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24337">
        <property type="entry name" value="DUF7505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2305"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2339"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2369"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2403"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2436"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2480"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2512"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="191"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="296"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="401"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="512"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="608"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="710"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="811"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="919"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1278"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="1360"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1565"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="1608"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1769"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1806"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="20">
        <location>
            <begin position="1930"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2562"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2562"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1304"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1795"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1814"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1833"/>
            <end position="1842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001342400.2"/>
        </source>
    </evidence>
    <sequence length="2728" mass="309192" checksum="201D815FA7F9A976" modified="2015-12-09" version="1">MRKIYWILYFYIFFLLPYLNECYINHPYLYETLPIKSQLCIPCSLPQNSTIIYLPSSRPICLHEGHPIFIFSLGNDSKNFDGSKNCKIPYEIKSSHISLDTTNGIVFAKRRMCFYNSNIKIEYRYKCYSFDDYKISTFLLAHRKFSIPFSEDNTNATKLKYIIPSESKIGRKRTKRWLRRRNPIISPIHFSQEKYNVQISEDAPPKTAIVNIKAEHEKKRSLYYSMSAPEDSRSGDMFALDTVTGQITLVKSLDHESLPKHVLKVTAFERLDPSIISSVLVIIDVIDVQDNPPVFEKTSYFAEIREDAPIGTTVLSVFAQDKDSGDNGKVEYFIQPSPGSDNLQINPHSGVIQTLKQLDRETNSLIRLKVFAKDFGTPSFNSSAYVEISILDVNDNIPTFDKNEYHVYINENESVPYSLIQLNVTDNDAEENGKVHFSIITSSGTSFSIDYESGEVTLKEKLNPKMSPYILVVRAKDSGQPALSSRSTIYVHVKDINDHQPLFITFHNEFIIEENVPIGTEVGRVEAIDDDTGLNGEIKYYFINTDQSEFIIDHDTGIIFTNESLDRETIDKYSLEVMAIDQGDTPLNSTIKIQIIIKDINDNIPQFEKEVYEITMPEDVQKGSQILIIKANDDDLDTKIIYKIEKTDKEIFSLTNLGGNEGALLRLTKSFDADDTNINLLISATDQGGKKGYTTVKINVNDVNQKPYFIKHSFNIIIPEDSPIGFHVTQMKANDNDRGQNANLSFFIDNEDFRINRQTGVITVGKPLDREKQSSYTLKVTVQDNGIPPLSTDTLLEIIIDDVNDNSPVFVEQAYFISIPEDMPVGTSFLQINALDSDSGINAVIDYYLDENDEFVKMDKFRLDRTSGTLRINQKLDRESVETFILPVIAKDRGSPQKISKTTVTIKLEDVNDNAPQFEKSSYVFYIPENMPPGTLVGKMSATDPDIGDNGNIQFKIFGGADAKYFEIEIDLNNTNTVFIKSRVEFDFEDKINKFQIEVQAASKQLSSTVPVHIFVTDKNDNKPQLRNFIVLITKFSGEYFEEIGSIPAFDPDQNATLEYFLEPNEILSVEKRSGKLKLLKLLNRHVSLQLKSCVSDGSNTECSVCHLRYHPIEEKDLGEAITISINDMTKDEFFDYDVYEKFVSAIASLNNHWTSNDIAVIGIEEKNNTLSISFIINERNEITNTWIIEEMIVEETSNISSLFGRSIELVRDEICNTEPCPYYQQCKQTFKYVGSDNKIIETDSFIYRSFENKRSHICECPPGFGTMFDKIGHCNVKIDMCYASPCKNNGTCHSLENDYRCQCLPGYSGKNCEISSELDTCLPTSCHSNSICTIKNRKPTCQFCRWEKTDTDDNCKLRSISFFGDGYVVVPVTLPRLQWHIKINVATIVREGLILYAGEMKQTIKRDYFMLYIKNGILNAEISLGNEVAMTSMEDSKENRINNGNWRTININFSSRQLVISLDDCDSFLALHHNNTFGYPKCASTTIIKLPKICNDLAVPCNRFFDVKTGLFIGGIKNNKISSNHISRFNGCIKDLYIDDKLIDFSKFPTFEKEGKVIEGCKQKRDICQYSNPCDSTAKCIDKWDGHICRCHHRVHSKLSCNQESSSAISLFVDGAYGSWKPTNNYEARHIYFEFRTRERNTQVMVIEFEGQAKYFILNIEGGTTVFNLDNNLYLMQYPVVSDGIWHSISIIIDPSTNNFNITIDAIYSKVIPSNENKLRRIINNMHTGQTPSFLSSSKYRGCIRNVEINSYRLKLHSQSKTKPGCQAPNECSTNTCPRFSKCIRDWDRHSCKCNNGYVGDQCVNICSIPNICGIDGICNLKNNTQGYHCLCPDNRIGFNCEQEKVYQICPHGYYGTFPNCKRCNCDTTKGFKDTCNTITGKCECPRNHYMLNGKCTQCECGIGSSSSTCDESGQCPCVGDATGKRCDRCENNLELLDKKTMMCIKLKGRCPSNIESGIQWPTTVFGSTARQSCPFSQIGIAYRKCDTSGVWDMVNLDNCTLKSLHIGNNKLWQIDTIMDVLQLSSLLKNSTKEISYVKGKNIDVWFTIMDTIIKSNSLKDSHIHNHIFAENIVNAASLIAFDCNYSKQMNLIQLLYNFGKKLASIHYDYSFLHPFQISTSNIVFSIDNIDEMDDVNAKYPAPIKLPKFDHFIDRMEESFKNLNIEVSSRYATGTIFYMIYSPSNCDKCESSVVSAYQVLDVDTTKLSYDMGINIAFPIKYHGNWKNYECVRLVNGKTYTINGFSNWNIQDINSSWSNENSLMIGLNSTHVVCQFTGSGIFSILGETVNGFQIQLTSNIGEMPYVHETCGILTLLGSTASLILLFFLKNIDQRGIKTVIVTGYIFNILTVLLIPRINYSSVYCSTRNTIFTLTTTFLFSWILLYTLTIYNTILSSNQSISNIILLLIGVVLPPLHSVSVFFYSTTCSIILFSETFWIIVGPICIIVLAIFYTTTTSFLLTRNKSYNIIGYSLFDYQQTITQYLFFAIFCVFTNIGTWSKLLGYQRSPLMDVLNDFIILIATVLLFFCISSSPKLKTNPQSSNELWLDQKINSVGSNSSTVLHNDGSSGTISPNSHNLASNEKSSSNYDEYDHGGGEPIYKSSKNNQWTGKIDGIQNPIENIDNTYSKYSPPNILQRHTTSLIQKQVVGPNILSPVQKIIRIDGMIESINSESIIPMIHGSSHLKSTISKNYDSGMGEESVLNYEDASNMYYAYQEKNNTATTTFRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6G4</accession>
    <name>A0A0N5C6G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6G4"/>
    <dbReference type="WBParaSite" id="SPAL_0001353200.1">
        <property type="protein sequence ID" value="SPAL_0001353200.1"/>
        <property type="gene ID" value="SPAL_0001353200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895445" evidence="2">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001353200.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29783" checksum="98C6DD5A34C7AA3B" modified="2015-12-09" version="1">MENKIMLFFGLFLIIFSLNVIQCEVYESKPSELSKAATYVQEYLVSLDDLDKSNIKNNIIKKDVSGVEEQKYTSVFSFNVIQSKLYESESDELSEAASNVQENLVSLDDLDYSNIKNNIIKRDVSGVDEQEYPTGESMRVQSEQFRHLPSGHSRAKRLLQFRGQRRNGIIGILGRIARIAKGLRAGKKGRFPGRRGRSRGRSTSRDRRDRQGSKRKGRKRKNRSAAGDPDLLEEAAEEDPAEETMDPDYDCDFSGESVYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7V2</accession>
    <name>A0A0N5C7V2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helitron_like_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7V2"/>
    <dbReference type="STRING" id="174720.A0A0N5C7V2"/>
    <dbReference type="WBParaSite" id="SPAL_0001401400.1">
        <property type="protein sequence ID" value="SPAL_0001401400.1"/>
        <property type="gene ID" value="SPAL_0001401400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001401400.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35639" checksum="D03778E7CC616814" modified="2015-12-09" version="1">MEYPILYKDWTVVRLAVHLINEDCTVADEMNNGNNNCFKADKGYKSTLLAFYNLNKNDINARKYLYNEIPEYYWFDLKTREWKLRHRQRRTIGRIFTVSPMNVELFSLRQLLLHVPGATCEGDLKIVNGFQWPSFRDAAIARGLLDTEDNYNELFEEACESAMPNMLRNYFGLMICYWPSFTRHYDTFIKFKNYLIEDYLMKYNGNEERAEAQAIFDIRNVLQSNNFNGYTDLPEVNFDIIEIDYVEDKDVLKRLGDENLKSANEEQRNFINRILNIIVNNFSDKRCFFLEGPAGTELKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8V3</accession>
    <name>A0A0N5C8V3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8V3"/>
    <dbReference type="STRING" id="174720.A0A0N5C8V3"/>
    <dbReference type="WBParaSite" id="SPAL_0001433800.1">
        <property type="protein sequence ID" value="SPAL_0001433800.1"/>
        <property type="gene ID" value="SPAL_0001433800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001433800.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32661" checksum="25266804FFF9437C" modified="2015-12-09" version="1">MLSKRDILAIMLYEFKRGTNAAKTTQEINGTFGEDLVSLSTVKRWFRKFKEGSEDLENEERGRPGSVLDNDKLRKVVEANPRTTVRELAEELNVSKSTISNHLKEIEKTKKLDKWVPHELNDYQKLCRYEVCSSLILRNKNDPFLSRLITCDEKWILYDNRKRSGQWLDKDEAPKLFPKPKLSSKKLMVSVWWSAAGIIHYEFLKPGETIDSVSYCQLIEKMHQKLSQKRPAVVNRKGPILLHDNAKSYVSKMTLQKLCELGYETLPHPPYSPDFSPTDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Q3</accession>
    <name>A0A0N5C9Q3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Q3"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Q3"/>
    <dbReference type="WBParaSite" id="SPAL_0001463200.1">
        <property type="protein sequence ID" value="SPAL_0001463200.1"/>
        <property type="gene ID" value="SPAL_0001463200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF22">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="450"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001463200.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="81091" checksum="2C14B2FE585F2057" modified="2015-12-09" version="1">MLRNKQRNAMLSTLRRKKGRGKTGPNILDEIDINSQLNGDFRKALKILDGCTSSTRAFKYRELVWEISERGTMGENLLHMCLLHNTNKLKYVAKELVRKYPKLVNDIFISEEYYGLSPLHQAIVNEDIPMVYFLLKNGADVRQRCYGSFFCAEDQKASRTDSLEHEWVDLDSSTRYTGQMYWGEYPMAFAACGKQYDCVRLLKIFKADPNLKDTNGNTVLHLCVIHSLEDMAKLIYKVGGKLSITNNLGFTPMALSARLAKKEMFDLMLDLGKETLWTYRDTTCYAYSLRGIDTVDEINGQLNSNSILSLVVYGESSRHLNFFDGLIEEILQKKWEAFGRRMLFRSLTGYLIYLIAFYTAFMTREIVLVDNEIDNISHQYNNYSLLYYEYRTSCYLWNYNDKEGNYYQKARMVGEIVSLIIALLLNLSEIKEMIQVGQYRWWKMTTAFPEKALYKISLVIVILMFCLRLSCFIHPKIVQIENILAIIAAFLSTTNFLFYCRGLKFVGPFVIMVYKIIIGDMFRFLLIYLIFLVSFSQAFFILFLSCERENNYIYMVHLFNNSSNENFDNILQKPSQTIMRMFLMSVGEFSAIYRNIYQCKSSLAIQGKIMFLVYELLVTVMLLNLLIAMMTRTYEKISETHKEWKRQWAQVILMIEQSLSPQERLLCMLNYSRPLKADTTQRGFLVRKKIKINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAN8</accession>
    <name>A0A0N5CAN8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAN8"/>
    <dbReference type="WBParaSite" id="SPAL_0001495800.1">
        <property type="protein sequence ID" value="SPAL_0001495800.1"/>
        <property type="gene ID" value="SPAL_0001495800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001495800.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="45435" checksum="702916ECED1E2580" modified="2015-12-09" version="1">MFSRMRCKELTTVKDNPPLTSLPNEILLIIFTNLDWRSLEILKLTSKSLYNLIEYTYLPTKFVEEIELRSYSTVDNSLRISFAIKTNKHQIEINDIPFYIKKKYTYIDKIEKILEKYCLRSVPKINIHIKDDSIVFDLLNRYFQYGTEVGCLKIFIEKSPVFKSFSRFMDKMKYVKCLIIECLCFDNQKIYTNYVFSIERDLKKLIINECRCCVFVNQKMITQLFENNPNIKLVKMNSNSDDIDKLIINYVTSRPDKGDNGKCHHPLFKLYLPFNEERIVKSEFNRLFPSESYIYQDYKNKDTYNTSTFGALKICSNGCHFKEIVIDCSEIFYNQLYEDEFSLYEHFIVDNIFEIFLVSIIFFVILLLFFIVLIIRFLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBD0</accession>
    <name>A0A0N5CBD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBD0"/>
    <dbReference type="STRING" id="174720.A0A0N5CBD0"/>
    <dbReference type="WBParaSite" id="SPAL_0001519300.1">
        <property type="protein sequence ID" value="SPAL_0001519300.1"/>
        <property type="gene ID" value="SPAL_0001519300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001519300.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13072" checksum="6AEBE95827AEF972" modified="2015-12-09" version="1">MTFGPPCRTSLQPSSNAKQNTMRSLERMSNRLSRSNFKNGFKKPLMKNYIPIDRPCDVIFEEDRKLAVDYSRPEEIDDEIIVSGAGNVPKCYKTWEEANFYPALQNTIKNSGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBM6</accession>
    <name>A0A0N5CBM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyco_hydro_30C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBM6"/>
    <dbReference type="STRING" id="174720.A0A0N5CBM6"/>
    <dbReference type="WBParaSite" id="SPAL_0001529300.1">
        <property type="protein sequence ID" value="SPAL_0001529300.1"/>
        <property type="gene ID" value="SPAL_0001529300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529300.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9634" checksum="25866F19801382A4" modified="2015-12-09" version="1">MTHVSKFVRSDAFIIDSVMENKINEFDFVAFKNTDESKVLIILNKNEGDLNIKINSINSNAVNIGIVRVEKYSFKTIVRILNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCS9</accession>
    <name>A0A0N5CCS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type E3 ubiquitin transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCS9"/>
    <dbReference type="STRING" id="174720.A0A0N5CCS9"/>
    <dbReference type="WBParaSite" id="SPAL_0001567900.1">
        <property type="protein sequence ID" value="SPAL_0001567900.1"/>
        <property type="gene ID" value="SPAL_0001567900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000625">
        <property type="entry name" value="E3 ubiquitin ligase Rnf157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001567900.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54582" checksum="B674D4E54C6B1753" modified="2015-12-09" version="1">MGQISSNTRNSNIFRSRRTSDNTNTRGTEEGVEIENFQPKSDGTVFGSHFLMGGGIYESVKHDNFLFGDLTDLEHVGNKPTHFPYEIQPGPDTIATLNTLVNIRRNSICFGKKKDKSDSEVSLEFTFDCDSPCYVQIHFHAKEYIEGLSLSIMYERDKTMSSKKFYYDTGSNILFNQFTFQPDDYDLVAVPKNFNENGEVSDISSSPYSQVVIEIRSVDEDNLDKQHTQLTFCNIVKSNDRNSFLMLKPQRQKLFVDGVLYLLQEIYGIENKEYENSMIDENGSECIICMSDIRDTVILPCRHLCICNNCAETLRYKQNNCPICRSPFRALLQMKTCRVIGNGNSNEGPGNGRVKYEIQTLIESLNGTNSSMSHSKQHLPKLGSTSKDNDKEIDNNYSTTSLSKQSPSISKNSCRKLQEVLKANNTTDVSVIVEEEPIEMYDLDINIEKNVDENKKVVDEEVCHERENSNSEEIKKNGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDU2</accession>
    <name>A0A0N5CDU2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CDU2"/>
    <dbReference type="WBParaSite" id="SPAL_0001603600.1">
        <property type="protein sequence ID" value="SPAL_0001603600.1"/>
        <property type="gene ID" value="SPAL_0001603600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="82"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="842"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1385"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001603600.1"/>
        </source>
    </evidence>
    <sequence length="1484" mass="173895" checksum="E935CC8BBA3D5FB1" modified="2015-12-09" version="1">MSNTDRNIIKSLLTVPEKLIKEELNSNNYCDKVWILDLPYKLCTLISQIDSNEVVVGFKDNNGIFKKKNVKKQLTQSVSSNHYVDDMCNLSELNEASVIACLKARYINANLIHTYSGLFCVFINPWTSSVSKIYTKDVKDFYKNEFKVEKILPPHIYYVAMSAYDGILSGNKNQSILITGESGAGKTENTKKIIEYIIEASDSSSSKCNKMQNDLINSGIVLEAFANAQTIHNCNSSRVGKFIKLDFDKNGKLNNAKINCYLLEKSRVVFQNLGDRNFHIFYQLLSDGVDKKRKMSLGLKKPPNEYAFLSHGKIKNDANLNDKEDAQSTINALLMLNFTEEDISQIFEVLSIILLMGEIKFGERKGLDISFVESMEYVKEVCRLSQIDSSKFVDALTQPTIKIGDKLIRKNQNLKKTLSSVLGLSKLIYDKLFNWVVDRCNEILLNNDSNNYSSSFIGVLDMAGFEIMNINSFEQFCINYTNERLQQFFNHFMFIKEQSEYLNEQIEWNEINFGVDLQPSIEMIEAPMGLLTLLQEECVVPNGNDISMLEKLTKTLDGEIFQKARQSVKNNNNSHFTIKHYAGIVGYNIEGWVEKNRDTVDNNVLEIMGTSNHSLLKIFFKNINNANNNTNKNSRTSTTVTSLYRESLHNLIEVLHSTNANFIRCIVPNYEKRAFLMNETLVLNQLRCNGVLEGIRICQRGYPNRMSFNDFINRYKCLLNYNSKEIQNSLRRQVGSKNRDAAVILCNYIPIDKEGYQIGKTKIFLKIGVVSQLENLRKKYLFDCTSNFQGICRWYIEQKILKYKYNKWDAILTIQDNVKQYIYTNQWDWWKIFLKVKQIIPIKQNEKKIVDLINQNKQLLKELEEMKILLSEVEKEMELLKRELSILQKDLETKDDTYNELKIEFTNSEKLLCFMEKRFDEQQSTLSKMQSVLKQNERSLEKLKQEKELLEKEICQLKESYHTEQTLRQNFESEYEEYYNKYETLEKKHSQLLENSKNYIECLHSMEAKLDEQKDLSQKQNNKIVDLQNTIVELNDNINKLDSILNSERHLKRKIEDLKDDMEEKLEDLRDKLERSKGREETLKNQCIEKDRKIEKLENKIDQKSEYMDECINELKKMHKETQQEMKNQLDEYRRKCSKLEQDNRTLKIRVADVDDINEKSIIEDTDSYSSYKSNSRLGSRQPSLQSISYQSSTSNMTSSRYSTRSSLLRRRETEPDIFMAASMVSNENLSTYGSLNRSPSFNSSRYTSNDMGKEKKICNLEKQIQNLNQENQLAKRELEVYKTNLVDMERRNSSLKNQINAMTIENNNLNNKIERQEDEILMYEERLKKYQKEANIWKQKYEEMVDESRKELLMHRKKSEEKLKEICFEYSKKLHSYSTSDRNKIKIQEELDETKALLDSTKAQLYEVKKHSKSQSILGDNWENKYRSCMTEIESLRDENASLKNKVRRQYKEIELLTQQNEIKEECAMFEKKVDSFQERVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE62</accession>
    <name>A0A0N5CE62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE62"/>
    <dbReference type="WBParaSite" id="SPAL_0001615300.1">
        <property type="protein sequence ID" value="SPAL_0001615300.1"/>
        <property type="gene ID" value="SPAL_0001615300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001615300.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19878" checksum="9C94F428ED791A48" modified="2015-12-09" version="1">MDVNANGGVRIRLDNDEVEKLIKILIHHPSLHVGTPRERESDEINDLLELSNKIEKLDGNLVCSCKAIRSVVKQSGANFEDILKMINNERRMRENCFSLLNKRISNMERLLMDKIVELEDIIRKMSSNNGGTSPNTKEADNANLSISTDSTRGVSGSSYTQSDDNVIEEDCNENSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE67</accession>
    <name>A0A0N5CE67_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE67"/>
    <dbReference type="STRING" id="174720.A0A0N5CE67"/>
    <dbReference type="WBParaSite" id="SPAL_0001615800.1">
        <property type="protein sequence ID" value="SPAL_0001615800.1"/>
        <property type="gene ID" value="SPAL_0001615800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000051">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="123"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001615800.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47879" checksum="1E6BE64D651CB657" modified="2015-12-09" version="1">MTIVDEKVLLSQPWYHGFLPREDMAVMLKQVGDFLVRLSEPVAGQQRANILSVMIRQDPPEIKHYVIKKTSHGKYVIEKYSFESIMDLIDHHMKTKESITNNSNVIIEKPIPKKNWELSHDSIVTTKKLGEGAFGEVCLGIWTAKNNQQFKVAVKVAKLEKLTKEQVKEIMKEARLMRKFDHPNVIRMYGVAAGMEPLMIVMELATDGALDKYLQKHDLSPSEKLRLCGGAAYGLEYLHNLNCIHRDIAARNCLYGDGNVKIADFGLTVEGNYYKMDGSQKVPLRWLSPETVKGYFYTSKSDVFAFGIMCWEIFHNGIEPYPGMAPAEAAIKVAKEGYRMPLPEFIHIEFRMMIQNKLWSEIDHERSTMTEVANLLERLNGTTRPKGGPGLDFDNDDHRKNPQSGAAYSKMKITKNRMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEE8</accession>
    <name>A0A0N5CEE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEE8"/>
    <dbReference type="STRING" id="174720.A0A0N5CEE8"/>
    <dbReference type="WBParaSite" id="SPAL_0001623700.1">
        <property type="protein sequence ID" value="SPAL_0001623700.1"/>
        <property type="gene ID" value="SPAL_0001623700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="600"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001623700.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="105028" checksum="EB1F26466A77680C" modified="2015-12-09" version="1">MILANDPLSLQTRFSPTTNSQIKSEPSSSTSSSASPASDSDDTTNVSSPMRQSISTQDIMSVSPKSESLHSVTTGESSSPRQNNSGNIIEKSLNIEKSTNINKLSTSTINSTMDFSLLLNSINAKEQLIDKNSFIKEENSSGKMDKGMNSLSIGLQDIIPKLPSVGLDNIHGNNFINTFTQGDPNAILQLSQLLTNSGNTNIFSGTNFSNFNGQLNPSNIQNPKRLAQDSSLNSNLQQSASGNEKKRSYPYTFQYCVLCQKNVHSSKLPCHIRQCHVAKPMFRCPSCDFTSTYSKNNVKSHMVSLHGLAGDPISYMDQYSSQVEEYMKKCFPNVRGRGRPVHGRNSPKSPQNKRQQIQSQANLISEQGSVNHLNAAGIPGQMNHFNMIYNPLFNKNINPNFAATLTSQNRFTNPQIPTSISQLNTSTFPPPPPGNWANFSLSSGNEKNYTPVMLQSNPLNIFPYLNNTITKNDCSLINIQDGQKLEIPSISEDNIKRDKQNNTPTTSLFNISNVSEFLTNLKYKSPGECIEGYKVENNEIKLKGIIMDDEFLKPKYFGLYPYNTLCLLDKDFIKNTVFDMPISDYHNIAEMIKKSRLDIHQHKNQEERLLSFEEQSKIDEIKKKLKAQPFEILFALHKYDISVLTAEDISLISSIAPTSVDILRIRKLTQNNKLPLNDAESFISQLASIENLPKKIYTMNFIFNKFNNLSSNVINNYRKISTLVKELSQNNTLNELFKIILITLNTICYVDNEPSNNNIDKISTNEENLSIIKGFTFESLEELFVPKINENLSNSENNWKFNETLKNIVSNILVEKSKKEEIKELSNTVKKILDFNFEDNDKILSIIEEGFKILEDEKDLMSDKSKEIVSKFMESSYKNINDIKKEKVKAKNTIDACIMFFCASMTYGTTNSSIRAFFSKLNEILENLITAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEP9</accession>
    <name>A0A0N5CEP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEP9"/>
    <dbReference type="WBParaSite" id="SPAL_0001633600.1">
        <property type="protein sequence ID" value="SPAL_0001633600.1"/>
        <property type="gene ID" value="SPAL_0001633600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001633600.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10111" checksum="36A018DA6EFFEBAD" modified="2015-12-09" version="1">MDTPIDWDTPIREDTNGISSSPFSTPSIGVPKLVKYNFNDKFEKVKIESGQTNDNLNEIKKILEDEKKFDWQRTPFEGIINAASWNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGP5</accession>
    <name>A0A0N5CGP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGP5"/>
    <dbReference type="STRING" id="174720.A0A0N5CGP5"/>
    <dbReference type="WBParaSite" id="SPAL_0001702100.1">
        <property type="protein sequence ID" value="SPAL_0001702100.1"/>
        <property type="gene ID" value="SPAL_0001702100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001702100.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24540" checksum="1C1CC871E0F36DE2" modified="2015-12-09" version="1">MSTDDISYKFSLTSPTRGKIFWSSDFLENLQSISSSEDGMENKYDYGCLIPFGRINESMCFYKELNIVCEIKYKIPNEGSTGINIFNEKSGSRILDYERHGNQLYDMYKSVNTSDCTIVFHGKFFFVHKFILMAHSLAFRKLFMDPDSKESKGSCVTLCDTVESQAVEMMVNYLYKGELPSDIGQKQIKDLLHLAVTYKIDNLKLLCESMLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGX7</accession>
    <name>A0A0N5CGX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGX7"/>
    <dbReference type="STRING" id="174720.A0A0N5CGX7"/>
    <dbReference type="WBParaSite" id="SPAL_0001710200.1">
        <property type="protein sequence ID" value="SPAL_0001710200.1"/>
        <property type="gene ID" value="SPAL_0001710200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001710200.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23676" checksum="8A9E3C4010B93E5F" modified="2015-12-09" version="1">MGPKKQISMEPGGAESKKRPVRRYRNTNSDKKRTEPLKNEGSNVTIMKEFDGKDDRIWKKWTEEEKRLLQEFTKICPVKNGRFQYKQVAKEFNILMSKMNGRSAARVQSEIKEISNRHMPKYAEILNSPEKVEEDKEVPIPTTKITEKEEEKSEKKKVIVINKIRRRIPNLRCGRDVIHKDRNEKCNVSIFDPLDFRFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH05</accession>
    <name>A0A0N5CH05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH05"/>
    <dbReference type="STRING" id="174720.A0A0N5CH05"/>
    <dbReference type="WBParaSite" id="SPAL_0001713000.1">
        <property type="protein sequence ID" value="SPAL_0001713000.1"/>
        <property type="gene ID" value="SPAL_0001713000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="14"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001713000.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="54086" checksum="9C14F8DE4C9148A0" modified="2015-12-09" version="1">MKLTKVEGKLNGLHWITTSLFIVADLAGGGVVAMPLAMVKSGLICGLIIMIILFVIFTYTAHMLGHNWIRMCQNWPEYTDHCRKPYPEMALRSMGERSRTFTSFVINAMLFGVSIVYLLLASKIINDIIFSLFGINIGSCLMLLIVASVMLPVTFLKSPQDFWWAIVVAMFTTLFAVILVIGGTIADYNTCTPVSYYPSFSMKNLFLSLGTFMFSFGGHAVFPTIQHDMKKPNKFTRSSIAAFILVLTMYVPVTVLGYIVYGDSVQDSIISSLQTPILQIVANALIAVHCILTLTIVINPLNQEVEHVLNVPHHFGWQRIGVRTFVMTIIVFTAESVPNFGPILNLIGGTCVTLTSALMPSFFHLFMETRLKMIRDNVNEKKDESEIYPSIVDVYKNTKTTKLVINCVIIILSIICGIATTISAIKEMGDSQFSMPCYLKNYFDSYDSPTPKIIESFKLINCCGKYLNESRYNDINVCLNNISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHN6</accession>
    <name>A0A0N5CHN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHN6"/>
    <dbReference type="STRING" id="174720.A0A0N5CHN6"/>
    <dbReference type="WBParaSite" id="SPAL_0001735000.1">
        <property type="protein sequence ID" value="SPAL_0001735000.1"/>
        <property type="gene ID" value="SPAL_0001735000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001735000.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29646" checksum="0897658DDF97117D" modified="2015-12-09" version="1">MEAHEDFSKEIPEIIQDPITKTQYSRGELLGRGGFANCYLFTKLENGEKFVIREVACEISYLHQKRVIHRDIRPDNIFLTKDMNVKIGDFGNAVKDVDSVDKFLKASGTPSHLSPESLDGTGYSFDVGVWALGTTLYEMIVGHYPFDNTVDSVLYDNIKRSDYSIPSTVPAHTANMVRIFLIRDPSKIPTIEDVLRYDYLSSRSISKDHLRGYISGKPLAKTINQEGPYECNAMPPSRNKNIPKEDCGLSEIVELKTSSKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHU0</accession>
    <name>A0A0N5CHU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHU0"/>
    <dbReference type="STRING" id="174720.A0A0N5CHU0"/>
    <dbReference type="WBParaSite" id="SPAL_0001740200.1">
        <property type="protein sequence ID" value="SPAL_0001740200.1"/>
        <property type="gene ID" value="SPAL_0001740200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004950">
        <property type="entry name" value="DUF267_CAE_spp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31930:SF5">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31930">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03268">
        <property type="entry name" value="DUF267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001740200.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45289" checksum="50E5E1A15D32C438" modified="2015-12-09" version="1">MEKAENNIGPYEYLYNIESLNNKLVISKHYPKMPTSSLLVKILKIIFTVVIFVPLVISLIWHILVEHQSSFLSLENLENSIFLSYYITTIIILINFMRMKTSNFFNNLLNYVKEYKEIYFNSTFVIKRKFTTIRIKLLLLWFILLVSFTYELVINVLNYDKNERDGKKYKLSKFYGKETYIVDSMIMLYSRLIIAVMVSIYICIYEVVSFESETFEKECKYFIEEDFSNFSNNIDIISKKHVRLFKLITLSHTTAGTYTDPIVMQCVVTIIMAVPIIRYYFSTISDIIQAINYIIVLISFALIMVLHLSSISNTVKSLRNIKNIILNSPKIWDNGNSKVRETALSIISRTEHCDYHGKIIQLIPLDDKTIPILLIIIHIVAFLAGVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHZ5</accession>
    <name>A0A0N5CHZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001745700.1">
        <property type="protein sequence ID" value="SPAL_0001745700.1"/>
        <property type="gene ID" value="SPAL_0001745700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF55">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="212"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001745700.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="82075" checksum="155E8D1267B12F94" modified="2015-12-09" version="1">MNIKNASEITSLLGTGVLSMIDATGVYGPGILRGNFIATGLRTECQSINIKINGRDRPLTADLAKTIKDLNSSTYTLGQECTAGAIKMYQDICIPSTCANYNDFYQLAVLVDRLWGHDTSAVCKIGVLNDKAVVNYQGIITYCVIGIMFGISILISLWELWILPHHKKLPYTKSLPIKFMRCLSMYTNVKSIFKIKSPPKKEGEPATTIEPIHCMRFFSMFWVIMGHSTSVMVAVTNNPLDILNIVGDYGTQFLVNAFFSVDTFIFIGGLLMSFIWFKNFKRNKRRTNSPMAWAMIYIHRFLRISPAYYMSIALYTFIFTKTWIRNFPRYYAAEFGERDPCTKNWWINFLYLQNFIDVDNQCYIPTWYLATDFQIFLFTPLIIIPLAIKPMYGYIVSGVILIISTVSNLATVYAYRFPPTDFAFGNREDLTVPYWKYTMLIYNAPWVRCQVYVFGILVGYFLQTTKKIKINKILVIVLWIIALGALAGIVLPVANWSAGNYMNLSGRAFYSAFSKIVWSLGLSWVVIACYYGYGGIINKFMSMKIWIPLGKLSFCAYLLHYMVILYFYGMDQGPFFFTNVLTTFCNVIIPVSVISYFLAIFWSAVFEIGISNMITLALTPPRKPQQEQKENVPNSVQVGKIDNDLSTVNDTNKKIEEEHSEIRQDVISNNFPMIKEVTLQDDNTYHIKFFSKLSPQKVEQILSYFLESENTEEKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIM6</accession>
    <name>A0A0N5CIM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF3496 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIM6"/>
    <dbReference type="STRING" id="174720.A0A0N5CIM6"/>
    <dbReference type="WBParaSite" id="SPAL_0001768100.1">
        <property type="protein sequence ID" value="SPAL_0001768100.1"/>
        <property type="gene ID" value="SPAL_0001768100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051381">
        <property type="entry name" value="CREB_ATF_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996">
        <property type="entry name" value="AGAP001464-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996:SF3">
        <property type="entry name" value="CREB-H TRANSCRIPTION FACTOR HOMOLOG LET-607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001768100.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14222" checksum="1EF0D1F3C9C81067" modified="2015-12-09" version="1">LEERVYEYEYENKRLKYRLECSNNENQKIILQLRKLQSVVNKDSKNNTHLSTCLAVMVLSVCFFVGHCYLSVSENNTNRNNDNLKEIRFTGRALFLGSVLKSNLSSQPSTDADYPVPCKKFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2A2</accession>
    <name>A0A0N5B2A2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2A2"/>
    <dbReference type="STRING" id="174720.A0A0N5B2A2"/>
    <dbReference type="WBParaSite" id="SPAL_0000020400.1">
        <property type="protein sequence ID" value="SPAL_0000020400.1"/>
        <property type="gene ID" value="SPAL_0000020400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="253"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000020400.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52627" checksum="F3FA763765354C05" modified="2015-12-09" version="1">MDTENINIQQQFIVFYHSSISYPSKDTSTDVEELIENHKKEPGEIVILRLTNSNLIIQTTTNNEIFNVSYKNISNYIWSKRLSPFFGISIINGDDDSCKKCCHIFSINTHIHDHTFHQKFNQIFHFNCLPSTQLLIKECQQFPTTVENILEATLLCKNKSLFKNNDNNTSSPSIIGDGVNDPLQCLDESIIKCQKRKILSPLFFDRMSNKRASLVEGLLVGNNASQYINKSSTLFSKDKTKTSTNLSRTTSSTFWETLQDPTLKESFMKFLTEQYCQENLSFYLIVAQYQCMESDSKRSTLGSQIIKRFIEDDADEQVNIDNRTRQTIIDTVGENEYPKNLFNQAYLQIEDMLKFDLMPRFLKTFNQQKVQDTTDKENTTRRKLSFNNIKNKLLKIKAKNSLLPQNVIPPKVPPPTPVNNHPNKTSLIVGTFRRSFVKPRPTIGYLFRNTTLSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2B2</accession>
    <name>A0A0N5B2B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2B2"/>
    <dbReference type="WBParaSite" id="SPAL_0000021400.1">
        <property type="protein sequence ID" value="SPAL_0000021400.1"/>
        <property type="gene ID" value="SPAL_0000021400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000021400.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17594" checksum="7BEA97AAD5DFB0CF" modified="2015-12-09" version="1">MLENNLIFIASLMPDTVERLKISRNFNLSSRITDKLNECMPNIKLLTFYNGEIKNSVCLSAFRNLELFITGGRRRNIFEIPKTIKCIVLDHRFFYTDNRNMNFKKELVRRCCESFLKYSRTNEGTYIFFNDVTQWGKYKRLVQECLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B357</accession>
    <name>A0A0N5B357_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B357"/>
    <dbReference type="STRING" id="174720.A0A0N5B357"/>
    <dbReference type="WBParaSite" id="SPAL_0000050800.1">
        <property type="protein sequence ID" value="SPAL_0000050800.1"/>
        <property type="gene ID" value="SPAL_0000050800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062101">
        <property type="term" value="F:peptidyl-aspartic acid 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039038">
        <property type="entry name" value="ASPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366:SF29">
        <property type="entry name" value="ASPARTYL BETA-HYDROXYLASE, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366">
        <property type="entry name" value="ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="4">
        <location>
            <begin position="664"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000050800.1"/>
        </source>
    </evidence>
    <sequence length="834" mass="96648" checksum="2EB69BC11AEEA110" modified="2015-12-09" version="1">MSTGNLLSGNVSNSRPPFKKQPSNFGSGYPHNMAVIVAPTKIDYSVTKGGLRTWAVLVTFIILCFTMAAIISEVEDDDYDNRDVNPFMAVINENEEIDSGNTIQTVTAEDVVVEQVPISMDDEEENKSLDLEIKLFKDLQKKIEKNKKHRNDNVKETTVKNGNNNEKDDDVGKKNYGKPNKQESYIEEHHKNVVDNDEDKLHVNIKNEKRKKKKIVEEEDNVDEKSDLKMNKQSDSSNDDKEKNDKKESLEVTEKSDLNKSKKHKHLVCKEIEEQDGNSDDDIDDKEDDDDTEDENDIDVKRKIKNRGPTKNKATLLRKKKLIEMYSEKRPRKSLLKKKRNNNKIYMTNYDFEEDDDSDEDESLDDDEEESAKVYNKEKFEEMGAYEIPSIKKPKYVGSFKKLYTNKKDQKFRGKLDAGDLYIEKHDFVNGEAMYNDVLKLYPESPRAHYGRGRLFEIRAEFENSNNLMDQAMLEYQIILDNDEATDAMFKEASESLIRCARFRGNLHKVLNIQRNMIDRDPQNLDLQNEFGITFLMMGRHEDAKKIFLNVINENSNNSKALAYYGYILKVFDKDLVNGVFHMKKSLLNGDFEHSDSKFFYHLGDGLMRLGRRQEAYKIYEKGAELGLFLSTYQRSIYNIVGLTAKAWWNIEQSGCVKSLKSIEKQWVMIREEVLNVWKEHSDLFLPEEHHLTDGSQKYFPLLSYGKIVENNCLLTPKTCAILQKYIKNEKCFKDNSKISVLQSHTTVWPHCSSTNHKLVAQLCLLTSSEARIRVGSETRGWKNGKFLIFDESFEHEFTYEGAAAGNNRIVLSIDLWHPEVPLEQRKLIIENSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4J3</accession>
    <name>A0A0N5B4J3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4J3"/>
    <dbReference type="WBParaSite" id="SPAL_0000099400.1">
        <property type="protein sequence ID" value="SPAL_0000099400.1"/>
        <property type="gene ID" value="SPAL_0000099400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893881" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000099400.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11195" checksum="956085F30FDE61B2" modified="2015-12-09" version="1">MNPLSVVILIGIFINISFEFKTDCTGNIVDVCTVYLTPSDDAYQTLLESIGYDDKMANDFNLNPYETEEQKIENVNNAIYGLSEETIVSIIIIDFKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4X3</accession>
    <name>A0A0N5B4X3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4X3"/>
    <dbReference type="STRING" id="174720.A0A0N5B4X3"/>
    <dbReference type="WBParaSite" id="SPAL_0000112300.1">
        <property type="protein sequence ID" value="SPAL_0000112300.1"/>
        <property type="gene ID" value="SPAL_0000112300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000112300.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20459" checksum="78790743EDAA8B59" modified="2015-12-09" version="1">MSDIEDKAVKGDVFYYFAYGSNMLDERMLLMNKTAKYFGNGELLGYKLAFYDHSETWHGATASIEESPNTKIYGCIYVVSRKEEGILDQQEKGYHRITVPIRNIKTKEVLYCRSYQLSNPNKKENLPSSAYKFVFTTGAIKHKLPDKYIDYLLDIRDNGELDKINVPLKCLIDVQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B556</accession>
    <name>A0A0N5B556_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B556"/>
    <dbReference type="STRING" id="174720.A0A0N5B556"/>
    <dbReference type="WBParaSite" id="SPAL_0000120300.1">
        <property type="protein sequence ID" value="SPAL_0000120300.1"/>
        <property type="gene ID" value="SPAL_0000120300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF4">
        <property type="entry name" value="TECTONIC-LIKE COMPLEX MEMBER MKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000120300.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="60560" checksum="77292E39701BFC14" modified="2015-12-09" version="1">MIKNYDSSSIYFTKNSVENFKIRITIERLGTLISGIYLANTDNKPITSGTISSRTQTSLGSTYEEVSQNINLNIGSGQITNQVIEKTSFYWGQLLENNFRQDDAKYDVDNEKPFNGADGNYDIIKKSRIFTIISNNEDSSVFKSTIGESEKIEKSFLTRNTKIKPINLITKKTKIIDNPTHKQKLEGRHIKEINEEMTIKVYLGASDKYGENYDESQEFTVGKLVLINKKMLIINGIIVNENLKIQGKDGFYKIHFEIIDNVVLSKLSFDNESFTNLLLYEDEEKRKEGDKNFFVNVCYLLTIQKTKLFPFDGVYIEYIIELPNNMMLSNEDNSVLTGRTHVSNNNWNGESYFSFPIELNCLLHLTKKFSSFPIIYFRICSEDEYNSFRINGYTSMHLPLQPGTHNHILTSWCPIENHSNYNKLYNLFLGQSLDIKEITKQCIHNKTCSSAIGIQTESRGNLYLTVSTIIQSKHLILNDEMSSLKYSVINERYITNLSLYMKIKKVLLDFEKARNTLLLIKNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B581</accession>
    <name>A0A0N5B581_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exported protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B581"/>
    <dbReference type="WBParaSite" id="SPAL_0000122800.1">
        <property type="protein sequence ID" value="SPAL_0000122800.1"/>
        <property type="gene ID" value="SPAL_0000122800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893909" evidence="2">
        <location>
            <begin position="29"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000122800.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="41326" checksum="FB2473C49B664F0F" modified="2015-12-09" version="1">MDIIFRHIFYFSLFLVLFLHNTIEGCGGRPNFNPQNKGEHVKKIFYDRSRETNKESLEAIDEDNNFTSKEVVKNNKIPRQKNNQHKDIKKRLKSSYRHKDSSYEEDDLDENDTHSKYTTNENTYDISKDKQLLDFPNSLYLNRGDVKNNNYNHTLTSFDIKEKLINNKESLISNKTLSTHTASTDIKNNFSTYDIAYTTRYDNSNELKNIYPTTSYPNEDKYYLSEEIYTDNNIRKDSYNLKLRYDISNEKKENQMDNYTPTSYPNENYDFSYEDNSYIRTKNNNSKITGIKNPQFYSLNKNNTNIDNKQVLEKRTKNMTVLSNELTNDSRYDRENSEGYYNSNEVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5F3</accession>
    <name>A0A0N5B5F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5F3"/>
    <dbReference type="WBParaSite" id="SPAL_0000129500.1">
        <property type="protein sequence ID" value="SPAL_0000129500.1"/>
        <property type="gene ID" value="SPAL_0000129500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893920" evidence="1">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000129500.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46026" checksum="6379086E0A587BF4" modified="2015-12-09" version="1">MKTFLLTLLLLLCINKGYADEEVQVESESNLKPRTPPPYNIGEKVNYFNYSFEVSALPKVGKDIERIFRQIKHSTCLTFEKKNTLIKDTIGINFNISDSGNKVELSDNKNRPTNVSLEEKIYTNFTMLRFYIGIALDIIPEIRRPDRDIDVNVNMSNVDDNFIQYYNITNSSYITYLNDTEFDFRSPMFLGPDFGSKNNKSTYEVLLYKGDQYPSGRNRPFRHNFYKDIFYYYCNGTAKENNCKYGGYPYPGNTCKCPEHFSGTYCTEFNNKSVIPTNYTIPAPLEANSTKLYYSVNLTNTVFYLNITSRGGKNVSTTVENITFSETSCSSTGSFLEVLIRKDKAAAGMHLCRTSTNFTLPSLSSEVFFVMEVKKENVYLNISYMEAEEKNKEQQEKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B617</accession>
    <name>A0A0N5B617_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B617"/>
    <dbReference type="STRING" id="174720.A0A0N5B617"/>
    <dbReference type="WBParaSite" id="SPAL_0000150700.1">
        <property type="protein sequence ID" value="SPAL_0000150700.1"/>
        <property type="gene ID" value="SPAL_0000150700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE R03D7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000150700.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38734" checksum="1DDEE85E98242966" modified="2015-12-09" version="1">MALVNAYRVHANGNDKKVDLYIKNKSLIGTGNFGCVIDAFIETVDNHIQHVAIKKIRMNKDDISIISRELYFLQLANHPCIVTLLYHYFVETTENVFHCLIFEYLPLDLAKLLETKFNKMLNSIDTMLYSFQLFYGLYYIHSRSVTHRDIKPANLLINDETGTLKLADFGSCIVLQKGEHYNPYQITRFYRPPELLFGAEVYTHKIDIWSSICTMIEMALGHPLFLGKCRADQATKILDALGIPTQEELISMNVKKINCRNRVPIGIIPDNKRHLLTEKMIDLIERNLVYNPSQRMETFEIINHPYFSPITQNKNFHREKDKLIPSFIKDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6E5</accession>
    <name>A0A0N5B6E5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6E5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6E5"/>
    <dbReference type="WBParaSite" id="SPAL_0000163500.1">
        <property type="protein sequence ID" value="SPAL_0000163500.1"/>
        <property type="gene ID" value="SPAL_0000163500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000163500.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39840" checksum="C69AAA86AA04463A" modified="2015-12-09" version="1">MSLSSNITYCEPLSKNSTELIVDGPLTLLCVVFGIIGNVQAILFLQSCKLNRRLVANMTVLFVWDCLLLIVAVLYYSLTSFFELFQINIQMDNFIVIFHGPASITLTSSIWLTLLIVVYRYLAVIKPFNGIDGSIYTVINNSTSFSQRIKFYKIPLFVVGLAILINIPIFFEMSYQDCYDRKTSTWSKNANPTPLRINPMYKTFYRLILKTTLESFIPFILAAILLALTQITVMRSNKRRMQLAPGSQRDHNEKAASYMAVIIVFKFLILHFLRVSLDVCEVFVEPNETFDLLAKVSNVLVTVNSATNYLVYLGKRSQKNTKKTSDRGKQLTLKVKNNEECHVLMVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Y0</accession>
    <name>A0A0N5B6Y0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Y0"/>
    <dbReference type="WBParaSite" id="SPAL_0000181700.1">
        <property type="protein sequence ID" value="SPAL_0000181700.1"/>
        <property type="gene ID" value="SPAL_0000181700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893837" evidence="1">
        <location>
            <begin position="26"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000181700.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="59930" checksum="9416B9B90B86CF4D" modified="2015-12-09" version="1">MKALLNILPSSLLLFFYNLLIYTNASDENYTLIYQYEIIETGNLSPEYQASRENRSTPVSIYVSENETKEKQLLVFKISLDIKNLPQLRVYHKMIFNIKYNDQELENIWIPNNETNRNFKLSNIPDDFHCNLIKCRIGFASIINVETSMHNHGDVLPNDFIYISLEIANNKNRFQLGTITVPTYIHNLYAVICPSKNWVSEYGLTKYNPNNHFMIHFSDGITDSFDRHIKLMNPWNRGEDNFCLCGHLEQNFGPSLDIGYNYYQYYASEPTLFVDEYSLVFENNTLICEEWDIFNKNVVAFIISIPQYNFQSNRTTVHQLTKHSKFYSGEIIAIMVLEEMKGWYDENDGFNDKFEVQTYCNVPNFNANLRLRINDTLQELTTIDDDIYGEIDSFTIDYKTIINNIPADCYLERDKQVFPQFQDLYVKNLRLHLQIYDEDDKKYYGVEALKLLESNKKYKCSLIVPPNHPDVENLILLKSMSSSLLEIRIYITIHFKIPLRILLTTPMEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Y9</accession>
    <name>A0A0N5B6Y9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Y9"/>
    <dbReference type="STRING" id="174720.A0A0N5B6Y9"/>
    <dbReference type="WBParaSite" id="SPAL_0000182600.1">
        <property type="protein sequence ID" value="SPAL_0000182600.1"/>
        <property type="gene ID" value="SPAL_0000182600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="96"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000182600.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51496" checksum="A3344365C516212F" modified="2015-12-09" version="1">MVKNNTTTVSNNDINEYYLPIYYSYWKEILYTVIFIFLYIGYKLLVRPLNRIKRLGDLGFYFGDVEYSKRVKEKMVERVKRLRVVGELPPVYPNGWFCIAESNQINKKCILPITFMGEQLSLIRSESGEVFLTDSYCPHLGASFNVGGKVVNDNCIQCPFHGWIFNAETGKCTSIPYNEASIPEQAKISTWHVVERNNCIFVWYHAEGDAPTWEIPEIDEVKYGEWTYRGRTEHEIMCHIQEVPENGADIAHLNYLHLHGVQEGNDVNKIPMNISKPYIKHFWNGSWEPRSGDEKHISVMHLDQVMKAGNFNLPLTETKLDAIQIGPGIVHMMFDFGILGKGIVFQYLTPEEPMFQRSRFVMYANVPRLWAKFMMISEAFQFERDIFVWSNKKYIRNPLYVKNDGPINKHRRWFSQFYTENSPKLQKDGTLTNKAKSTLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B786</accession>
    <name>A0A0N5B786_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B786"/>
    <dbReference type="WBParaSite" id="SPAL_0000191400.1">
        <property type="protein sequence ID" value="SPAL_0000191400.1"/>
        <property type="gene ID" value="SPAL_0000191400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000191400.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="33042" checksum="E074C576950F00DA" modified="2015-12-09" version="1">MISVFLVVDIIQLTYKIPSMLLMILSLYIIIKKIKNKNVHFNKQFYTIIVCKIINEIVYIITIFIFIKLPKWRFFDNFWENNYWAATIFLILTTQQATFMFLITLLTSINRYIAVKYPLSYKIFFSKSKIIIVLLFFIILSTMIGLGNIPFNPTYKKSNIFNCFAPTLKSKNVIYYQIFYTVFLFGIISIATCTFNAMAIKTLKKHNQVGNKYKKELYYVKYSIFIFITLFIVEAFFFCRLTALIYGTKSFLYIMYFLHIVAFDLTSVGDFYFLIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B795</accession>
    <name>A0A0N5B795_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B795"/>
    <dbReference type="STRING" id="174720.A0A0N5B795"/>
    <dbReference type="WBParaSite" id="SPAL_0000192200.1">
        <property type="protein sequence ID" value="SPAL_0000192200.1"/>
        <property type="gene ID" value="SPAL_0000192200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000192200.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="40946" checksum="116331357CEEB463" modified="2015-12-09" version="1">MEKIYSVKDILHPHQITIVMVVKSASEYNYEQAIETVKCYSWHYNYNFVILRQEKVSEFSYNCHYRDFMFRRHCIVANFAQKYKNEIKYIVFIDGDIGVVNPVHRLENYLPKDGEDILFYDRTFNYEIMAGSYIIRNTLYTRSFLKLFADYEYKMPKTNDGRDNVALQPVFVDFIGTVEHRKKYLQCMKIYNYAVGFDENMLFVSCMRYVLNLMDETPNDTNYHTYEGGKIKIVRKLSKKRWARDGWLSDWKFCNDDLFHHAWKQKEFKKRKNVFKRRFLSDERICRSSDFLKLWDYDNSFKKDCKTIYDRIKKYADKAHRHYLKEIIESNITEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S0</accession>
    <name>A0A0N5B7S0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase_S26 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7S0"/>
    <dbReference type="WBParaSite" id="SPAL_0000209500.1">
        <property type="protein sequence ID" value="SPAL_0000209500.1"/>
        <property type="gene ID" value="SPAL_0000209500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209500.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8579" checksum="FCB5F464612139E2" modified="2015-12-09" version="1">MTGHGSPFVLVGTRTEYGFVSGYFEITLALGCFQRISPFPYATTFGDLFGLFDLSEACYKSGNNFKSTSSAIRFIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B850</accession>
    <name>A0A0N5B850_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B850"/>
    <dbReference type="STRING" id="174720.A0A0N5B850"/>
    <dbReference type="WBParaSite" id="SPAL_0000222300.1">
        <property type="protein sequence ID" value="SPAL_0000222300.1"/>
        <property type="gene ID" value="SPAL_0000222300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF8">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000222300.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18363" checksum="D39D155E3F74E431" modified="2015-12-09" version="1">MMNHDESKTPSPQNNSPEQSLFKHIPMNSKVIENMNMSLFQEIKKRQMLFMKYFNAGDAQKAAEIYSPEGYFMPNLEKPLRGRAGIEEYFKKDMTDGAYKVTIITEEVNGSGDWAFERGSYYLSGKKTECGVYLQVWKKNHGEWLIYNDCFTVLKQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8N9</accession>
    <name>A0A0N5B8N9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8N9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8N9"/>
    <dbReference type="WBParaSite" id="SPAL_0000241200.1">
        <property type="protein sequence ID" value="SPAL_0000241200.1"/>
        <property type="gene ID" value="SPAL_0000241200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="33"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="19">
        <location>
            <begin position="542"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000241200.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="86605" checksum="F7892AF0520D890A" modified="2015-12-09" version="1">MAKEAKNEFEVPPPKKDIQMKQNSSNAGYTTLLTVTILGLAWIVGFSTRLFAVVRFESIIHEFDPWFNYRSTKYMVENGFYNFYNWFDKTAWYPLGRIVGGTVFPGLMITSGAIHYVFQLLHFPIHIREICVFLAPLFSGLTAIATYFLTKELWSPGAGLFAACFIAIAPGYTSRSVAGSYDNEGIAIFALQFTYFLWIRSMKRGSIFWAILCAISYYYMVSAWGGYVFITNLIPLHILACIITGRYSRRIYVAYTTWYCIGQLMAMQIPFVGFQPVKSSEHMAAFGVFGLLQLVAAVKFLENTVSRKQFFLLLFGFIGSAFVLGLAFIVLLTYAGYIAPWTGRFYSLWDTGYAKIHIPIIASVSEHQPTTWISFFFDLHVAAAVFPVGLWYCIKNVNDERLFIILYALTAVYFAGVMIRLMLTLTPCVCVLAGIGFSYTMENFLKEVKENEDDKKSKKTDEEKKTYDKVVKDTKKTTDKTAISMILLLVLYVVHCTWVTSNAYSHPSVVLQSHGQNGARNDMDDFREAYYWLRQNTAEDAKIMSWWDYGYQIAGFSAKSTLVDNNTWNNSHIAMVGMAFSANESFAYDIMTELDVDYVLVIFGGMVGYSGDDINKFLWMVRIAQGEHPSIIQEKDYFTERGEYSVGPEASETMKNSLMYRLSYYRFGQIKFSYNAPGGFDRTRGYQIGLTDFDLEYLEEAFTSENWLVRIYKVKKPKNKDRVKYSDMKMKFTPRSSTSNNKPGILNNKKTVVKGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9J9</accession>
    <name>A0A0N5B9J9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9J9"/>
    <dbReference type="STRING" id="174720.A0A0N5B9J9"/>
    <dbReference type="WBParaSite" id="SPAL_0000271500.1">
        <property type="protein sequence ID" value="SPAL_0000271500.1"/>
        <property type="gene ID" value="SPAL_0000271500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="178"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000271500.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45070" checksum="366CC9869F63184E" modified="2015-12-09" version="1">MNYEKGAKPEAGQFICFDHIRFYVGNAKQAANWYCTNFGFEPYAYKGLETGSRLIASHAVKQNKIIFVFETALLPGNQEIGQHLIQHGDGVKDVAFEVDDIEYIVNYAKKKGAVVVKDITKEEDEDGFVLTASLQTYGDTIHTLIERKNYKGLFLPGFKAHSYGEEFFKTLPKVGLDFIDHCVGNQPENMMEPAVQWYEEILQFHRFWSVDDTMIHTEYSALSSIVMTNYEETIKMPINEPAVGRRAVSQIQEYVDYYGGAGVQHIALNTQDIITAIVSLKQRGVEFLSIPDAYYDNLRERLAKSCTKVAEDIDRLQKLKILVDFDENGYLLQIFSKPCQDRPTLFLEIIQRRNHQGFGAGNFKALFESIELEQNERGNLFYKDVKTGGEKLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAY9</accession>
    <name>A0A0N5BAY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BAY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000320300.1">
        <property type="protein sequence ID" value="SPAL_0000320300.1"/>
        <property type="gene ID" value="SPAL_0000320300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894235" evidence="2">
        <location>
            <begin position="26"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000320300.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73655" checksum="1736FC2CCBD99548" modified="2015-12-09" version="1">MTKSFLITIFIGIFLFHLYPPEVHCQIAEIASLVTSILGGAGNGAAIGNVATAGAGAAKAIGNLGALYQLAQSAMQLTGTGVGIANQASESQWFPIVVEQAAKNHRMMTERLAAFNSGRAVNPLTFGETDGFGGAVTSYYRTTTESTLPSEYGSKIVITETTEYPKTSKSKPDLTKVDKEDNVDEYEEENNEKSGSVDKKDEDYSEEINNRIDVDNGENIDGLSEKSVKSENKSIEKIKDKSEEKNKSLKSGGEDKDEEESDEDDDERVETIKKLMKILEKSDLKKSEFEEIAKQLTKNGKEDKKTTTKATITTTTPTTTTTTAEEDYSSEETSESEERRRIIEETKRQLGHRTTILRRITTLNPRHSTLIKLISTTPLPDSEKIFPIPLSQAIKSDNNRPGSLIENDKLSKTTTIETSNPEKPRIILVKPESSMFKDPQGGIPIESVKKASKRIFTATIPINHNSDNLTPPNGIVGRPQQQINNFQTPTRIYEKNQPSINNVQQGNFVRFNGATTFNSNTNMPLQTIQGSNVPYQQNYNNRQQLPYQNNNNIINRPNGLYNNEINNYQQRTTIPSQAYHQTNVPYNNGFQQPYRAPFNQQQQQQWRGYNNNNNYYQQSQYHQSYYQNNANPNNNNVNYYTNNQQTQNGVWRNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE30</accession>
    <name>A0A0N5BE30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE30"/>
    <dbReference type="STRING" id="174720.A0A0N5BE30"/>
    <dbReference type="WBParaSite" id="SPAL_0000425700.1">
        <property type="protein sequence ID" value="SPAL_0000425700.1"/>
        <property type="gene ID" value="SPAL_0000425700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000425700.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30226" checksum="0560C23B436BA6AE" modified="2015-12-09" version="1">MLSKRDIRAIMLYEFKRGTDAAETTQQINESFGEGSEDLENEERGRPETVIDNDELRKAVEANPRATVRSLAEDLDVSTGTIFRHLKEIEKTKKLDKWVPHELNDYQKMCRYEVCSSLILRNKNDPFLSRLITCDEKWILYDNRKRTGQWLDKNEAPKHFPKPKLTPKKVMTLQKLNELGYETLPYPAYSSDLASTDFHFFKHLDNFLTEKIFRNDEDIKTVFEVFIKSRTPDFYANGINKLVSRYQQCVDSNGSYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE50</accession>
    <name>A0A0N5BE50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE50"/>
    <dbReference type="STRING" id="174720.A0A0N5BE50"/>
    <dbReference type="WBParaSite" id="SPAL_0000427700.1">
        <property type="protein sequence ID" value="SPAL_0000427700.1"/>
        <property type="gene ID" value="SPAL_0000427700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000427700.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="77085" checksum="4CCAE7CB0F916BEE" modified="2015-12-09" version="1">MTVIRCPPSDYEYTIKYQDKTYHGEYKKIQNAVRQVGISSPIMHYPYICQEEGCGIRFMFHADITEHYMLHHNILNPKIEFKKLNFPTHRYPSETRRNDGFYTINELMNFNEDDFKKHNVFFNRKSKSTTVIESSCPLKKKKSGPSIEKIEHLLSDFATVYEVPYVDEKGDILGDLGKNEYLESGKKVPKDEGNMDNVKIGGGNNEGTMVIDLTKAPEDGDSDDGIEYLGDYSSIKNSDTKSYASDHSEQHTSTPASSPYIKSSQQSRQSLSSSLNNLGAPDQPSRLTQTLPMRFSPGIQMKNASVERQIPPKITTGVGRSGSPKKHFPNINKPNNLLPGHINSSSKPKDDKDVLRKVTQILHENVPKRLSGPSKCNNVDETNNSSNFNTLKNHNPKQTTAISRPYQKTTNQDHQSQDKISSVSSTNMVAKSNGIPKRVDKLYYCMFSDDCNFFTRYRINYEKHMSDHAIITFLFRCNTCPLVFQTENVFIEHKTKYCIKSVGQVRPKFNPDISRHQEFINLANYYDLITCRYSDVCSFVCNKKEELRYHIQQIHEHDQVLYNCSKCEAQFKNKVALAIHSRNYCWKTMEMQIAEGKLMTCNAECCDFSSYSIPEWHVHMASHLYTGDQTPYECGKCYTFLATKTAQVEHEKYFCPLIKPKIIDLPNRHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFD5</accession>
    <name>A0A0N5BFD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFD5"/>
    <dbReference type="STRING" id="174720.A0A0N5BFD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000470200.1">
        <property type="protein sequence ID" value="SPAL_0000470200.1"/>
        <property type="gene ID" value="SPAL_0000470200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000470200.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40943" checksum="D6D593677F9241CD" modified="2015-12-09" version="1">MSSEVSIPIKKCVKCPELGPFFGFDSKRATYCKEHFIIMVKQKFFFALGKNRVFKDGKNRNPLLIFKGDINSSFLVGIIVEGKSKNPYKKIDIDPTIIAVTDEENLEEVQNFYIKTKDSFKDVDWPLHFVHLASIFNDNFNCVESSILGIDKINKLTEFCNLFKTPSAKIEIKRILWDLLYFKLGKYFNSDKVLLPVCADELGRVTCNALCFGRGASIGHLTEVVDNRHDGISLLRPLHDISQKEINSMLEFNLFTGWKIYEHERIDGEKSNTIQNCNSQFLDSLLYAGFPATIPTLLSISGKVRPNAENNILSCKLCHTKCGSRSEIQVMCQACFDFIETEMEANVETREMLEKIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFF6</accession>
    <name>A0A0N5BFF6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BFF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000472200.2">
        <property type="protein sequence ID" value="SPAL_0000472200.2"/>
        <property type="gene ID" value="SPAL_0000472200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF378">
        <property type="entry name" value="KUNITZ_BOVINE PANCREATIC TRYPSIN INHIBITOR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894280" evidence="6">
        <location>
            <begin position="21"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="289"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="476"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="539"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="756"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1584"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="2360"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="2710"/>
            <end position="2767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1545"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1963"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2595"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1545"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1963"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1991"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2603"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000472200.2"/>
        </source>
    </evidence>
    <sequence length="2770" mass="311113" checksum="3E8526C4A88D54F4" modified="2015-12-09" version="1">MKRSLALFIVSILLISNIRCLDVDPCKRQPFRGRCPVSGNGIQARSQFVLRYYLRNGECVSYPYGHCANDENEPKLFRYKEECQEACIGKRENESINRNDKDSLVRFAPTKTTTPGNIRNEETYQTNKPLDKISSPKILSECEKQRIDSKNVFKLECDSDGSYKQLQCNAEKQECFCVDENGKEIPYSRSLPTGVAPDCNAILTAEKKLFNKCTGKSVYGPCKANLSRWYFDEIENKCKLFQYSGCGSNGNNYENELACIDRCIPKKAMTSSEDESHTTTSQIDRNTVCSLPKERGPCEKYDLRFYFNKDLNECKYFFYGGCEGNANNFLKVEDCEATCGGKPSQIKELPPKNPINVTPEPKIFQTIQNKETPIQTLQSKETHFQTTFSPKPIPTTTEYPFTENRCIPPKDSGNCNGNFARWYWNNENKICESFSYSGCGGNSNNFANREECLSVCHINAVSKDDKAEMLDPFDVCSHKIDPGECGGSFLRWAFDKKTKTCVKMFYTGCQGNGNNFATEDDCARKCIPGRKPPQQSSACFHPIDVGDCDGVFPRFGYDRNTNECKQYTYSGCNGSPNNFGTYQDCAEACIRTPCPPMASCDLSRCHVIHDLNGCPSCNCPPINNKNPIINPPPLPVPTSHNNNCPIVDAASCLEPCMIFFNRVGCQECVCPKVPTTEKPPVKLPTNLGTPVIRNDVRPLPTLKTQEPKVEEETTTFQPSTRPLPVLPKKNEEDINSINNGFPSNSLTFKDVVGDKCTLPVDPGPCKDFIERWYFNINTGICEPFKFGGCGGSKNHFFTRHECEVHCARFSNITSLAHIKSITTPQPNIIKPPPLPILHSQNKFNNVIPIPPKIIIKPFIKNNKVNNITLKNNNFDKVNGENNNFNKSSIPTSTYLKIPVVVNVIKKIQKEEEKRPVDIVEDNDSEETIEIKQQLVSRGVWIPESMVTNTENFITTSINPPIEKSTQMSNRDITSTVKVNLPDQSLEILGNPNNRLMWIKDINTKTGVINKIKPEEIRPPFNGAIGSVMWVKRWNHKLKKYELINPNQYTFEEYQRRLRLGSNDNLQTVKSSSTANFIPQWTTSNPNIIENSRQFESLLKVDENMPKIQTFDNQVSTITPQRNKPPIDNFATISFDNNITPNQNPSLIPTPEQFPLDTINSGQKPIVINDNGINNKTNDNSQVMWINVWNEETQKKEIIGISKDLLQKSTTRIVLESVTLAPGKVLKPPTSENISPLIIRNQTSAEKEIVSNFINNYEKSQKKDNISKMTFLTTPIESTTISTSQQILIDNDDIDSTNSILLNSNKEPYLPENDISEMNLTISSEKFTTKPATTINAKVYKPAIFATKIPDISPLVTIFEELIIADDSIYYKTSSTKKEKIFENHELTTTTSGGNRQIFTEKLPVNYPIISNKSEIPNLITKNIQNDNKKTEQSEELTTKISKILVDDTSVENKKTIEEEVLTTEISKPSTIDISFENTTPKENNDMKLDTQTYKPMSTVYIKSLPFEKDYKSLNIENVKKDNFITSHTSTDAPFIEFTKGLSTKQSTVSQQTRPTQKKILKPQSNNSQLSRPLKQSAEEIVDICNLPADAGHCFNYIPRWYFNSQKGKCEQFSYGSCGGNKNNFFDRNSCEAECSSVILPKVFPSLPKECTFERDEGFGGQYHPKYYFNFRNLHCEQMIYQGQGGNGNRFDNKIKCENKCIRRIHEEEEEDSIKPLPVQQKPKFVPLPKDGENWGKETTNNLLNNNVKGIKIAESVDNQGKTGRPLPIQVIRTENSQLNVSVPSLESYQQQYNAREYQTKEDVSTTENHLSSVKVQSTIVPDNGGYPEMSLVPSQSTQATTISQNIPSTTTIRYETAESTSEKEVKPLTTEVESTPYEIETTTVFKNVVTEIEKVIDEIKPSESNILTLSTRSPISISTIGFETKEPTNEVVLNTVPTIKVVTYTDTPTTEKQTLPTISTFESSNTYSESTSVGNVESELSTESQTKPSITQSQTEPTTSFSTETPVQIQTKSSTETYIQPQTSIVTQTQPTTTTEIESIPNKVTEFVETVSSSTVPINIPSSVDIRANLTVQAGSSPSISETKIISKIAEIEDITTDDRSIKKLDIRPISPTSTIKDLSTEATTIKLETPTTSKQLVPNQPIEDDKDLLESQEFMKKDAIENRDEYKADKLTEKIINKVPKEQLPIVKESPDPKIDYQNRGGNVMNGISNLQINKDTQIMEELTPTINPRIPVCPNKKSALLDRTGSPLSCLPGKRPCPDRSSCIYNGVNFYCCPSPEDPYDHHVFGGYNGEEIKNGYKPLTKTLNIFSIVNNEPIKRAKRDSMGLENVYKSLRFEGAPIKQVSRANRLHVNGKMLPICSLEVERGNCEENHVRYFYDARIDQCRMFYYSGCQGNGNNFATQKDCERICKIEESANSKISKEQKSFVDVCGEGKMPFGGENPLVCGNENDSIGCPVGYTCRKEAPFICCPKIIEDVDDSNQLTIKDIIAKKNSKDTRFAPQTNSPYNPYKSNLPRLRTQSGIVIASSSNICPDGSDSLKEVMTGKPVDCGTGGDGHPLCPIGYYCSMDSFTNSRLCCQLGSIGTKLHAPVNESPFINQKKNNSKELSRKQELPVSDGVSSTTPQSPKPLPIAIPSIKEKKNNLKEYDHMMIKPVNKGNNQNEILLEENPKLLVDDTQETNLKHTDDSSILMVDEIAMLEPKKVIDKNACQVSPSEGRGCREDEPMPRTNLQYFYSVKDKKCKLFFYRGCGGSINRFESKKACEALCMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFH8</accession>
    <name>A0A0N5BFH8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFH8"/>
    <dbReference type="WBParaSite" id="SPAL_0000474400.1">
        <property type="protein sequence ID" value="SPAL_0000474400.1"/>
        <property type="gene ID" value="SPAL_0000474400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000474400.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35566" checksum="07794883709189BD" modified="2015-12-09" version="1">MSESVASYHIPSKDGTLSGGGFSPLSKSNQKSNTMSKIFPTNEFDSQKVKRKLDERIAIWTLISLLGATVVLIIYGSFHSTAHDSLEYYAEMAQDSLLRSGKFNQTIFQHSNGTIKSIIKTINVDKNDLTPQFLKQFIDNLKGLHSCVLNLIAFNIISFAILIALHIIYTFGRNQSGSIKVFYRLVIILILISLLFQAGICIFYLIPKTTYVRNDCDFLLEKSKPSFGLVKKQLEDEISCKFGLDEISIQLGRIDPCLPKIKNKLFSSFAGVLVLLFSLLPFALILLTALWDTWLKDQLFIKKGRSFFRKLLESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFY2</accession>
    <name>A0A0N5BFY2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFY2"/>
    <dbReference type="STRING" id="174720.A0A0N5BFY2"/>
    <dbReference type="WBParaSite" id="SPAL_0000489100.1">
        <property type="protein sequence ID" value="SPAL_0000489100.1"/>
        <property type="gene ID" value="SPAL_0000489100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF15">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000489100.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="60762" checksum="F2E1466E8ECC467F" modified="2015-12-09" version="1">MSSNNQDQSLLSNISPAIIQAMLNLNEKVNDEEMRMKFLPIDVSPTITKVDNLQYNEDKNNNSSEIIPLESHKNKDEVVPNNKENVTNNYNSSIHSLTSTSAFKNANNEINFVASTIVENNVTRRKRKPNDSAGNNSSIKKEIKASEKSNLTYKSKLSSSTENLNKSPDVPTTNNENGNCEEMVKQNEDNNFLFSNFNISFSPTMTSSNNKENKEKVSCPTPGCDGSGHQTGLYTHHRSLSGCPRRPDKSTIQLLSLQKDSVLRCSTPQCTGTGHVNSNRSSHRSLSGCPIAYQQKLAKKSKGRLPIYKNTSDNFDDVSSQPDGHLEFKKESKFLKTDCDKLLRSSTFLEFPLESKIKVFEESCKQHNQINLERHNDMEIHKKNILNIKENKPLINSHIQPQFPMHNLFPQNPQYLQPTANSGYIPAPTIAENLQQQMAIFALASQNVAQYLMMKNFFDNMISSQLASFHASTLVPPNNSATFMNFPLPPEIIDNKFNEEIQSLISQMNNPQNQILFGSSKFQSEMFETTSDNIDGKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGY1</accession>
    <name>A0A0N5BGY1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGY1"/>
    <dbReference type="STRING" id="174720.A0A0N5BGY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000523200.1">
        <property type="protein sequence ID" value="SPAL_0000523200.1"/>
        <property type="gene ID" value="SPAL_0000523200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033181">
        <property type="term" value="C:plasma membrane proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017385">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038097">
        <property type="entry name" value="V-ATP_synth_e1/e2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000523200.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9615" checksum="01356A1F62292CF3" modified="2015-12-09" version="1">MAVWIPLVAVSAFWLVIGIAGPIFVPTGPNKGIIQTMIILTAVCCWMFWIIVFLHQLNPLIGPQIPVRTIKWISKQWGDAPVLVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH69</accession>
    <name>A0A0N5BH69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000531300.1">
        <property type="protein sequence ID" value="SPAL_0000531300.1"/>
        <property type="gene ID" value="SPAL_0000531300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000531300.1"/>
        </source>
    </evidence>
    <sequence length="20" mass="2355" checksum="82C6F76FF399EE1E" modified="2015-12-09" version="1">XLSKVDVLRVSKGRLLFKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJB3</accession>
    <name>A0A0N5BJB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000603900.1">
        <property type="protein sequence ID" value="SPAL_0000603900.1"/>
        <property type="gene ID" value="SPAL_0000603900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000603900.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24922" checksum="654E91E3FAE5E75B" modified="2015-12-09" version="1">MKIKYPETKEIEKVNFSTVKLLDHPLKLGENRKLADKKPFVGEKVEQSSKMGKKLFPQHDDKLTLFSSKDSGGLRKRKRDLYIKLKLDGDEGQELNKDGELEWNEEQELDEDYEKEWDEGQELDENNEKEWDEEQELDEDNENEENEDKEPECYKDKEPEYDEDNMRIDEFLDIMRKAFTNNDTENNTNNDTENNTVKKEDPIKSFRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJF1</accession>
    <name>A0A0N5BJF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000607700.1">
        <property type="protein sequence ID" value="SPAL_0000607700.1"/>
        <property type="gene ID" value="SPAL_0000607700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000607700.1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4743" checksum="D025B223FF7687E2" modified="2015-12-09" version="1">LVFHPPSYHCLILLVFSLLYPTGRVCLSHHYFVKNSNIISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJG7</accession>
    <name>A0A0N5BJG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJG7"/>
    <dbReference type="WBParaSite" id="SPAL_0000609300.1">
        <property type="protein sequence ID" value="SPAL_0000609300.1"/>
        <property type="gene ID" value="SPAL_0000609300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894386" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000609300.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9421" checksum="6963F7FE14059CC3" modified="2015-12-09" version="1">MSVSYSMSIVLFLSLCCCRGAGLWNRYSEFPVCRRYGCTLEMEVLLNSGSLFSYHFLVQYCYKFVSHKIHVMPQIFQGTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK21</accession>
    <name>A0A0N5BK21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK21"/>
    <dbReference type="WBParaSite" id="SPAL_0000628600.1">
        <property type="protein sequence ID" value="SPAL_0000628600.1"/>
        <property type="gene ID" value="SPAL_0000628600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF6">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000628600.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20594" checksum="1BBF96435DE44305" modified="2015-12-09" version="1">VGYSFGGALATLAAIKLRYAQYRIGQDISLYTYGAPRVGNPDFAQKFDEKIPNSFRVVVDKDPVPHLPKCALVMSKYFKFSPKLTSKVCNIKNRLSYYHTGTEIWYPKGTQNLNSYYLCLGNPKNEDRKCSDMYRYDKTNLIKYKFYHYIYYNDIIQTYKSILMAIFDDNCGIVPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK91</accession>
    <name>A0A0N5BK91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HintN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK91"/>
    <dbReference type="STRING" id="174720.A0A0N5BK91"/>
    <dbReference type="WBParaSite" id="SPAL_0000635400.1">
        <property type="protein sequence ID" value="SPAL_0000635400.1"/>
        <property type="gene ID" value="SPAL_0000635400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894507" evidence="2">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="3">
        <location>
            <begin position="351"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000635400.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63339" checksum="7AE3D735F77E59AE" modified="2015-12-09" version="1">MFSNYICLLLAIFITTHKLTLSSFCGESSIPFSFEILPNGQPVLGCARPSCFGWDSDGTPLTNDAQFYRIHKKADGFLRKQSEDFRRVISEDDAKFFKPKQAKCSKTFESESCPGEDEWVGGIAPSSNYTDLPLAIQCCSYEELKESEDRGVAVVNVGQIVIGGEVFSGKRQYAFDYIKDILKHTSENGSVYYDVSIRRISCLPLPDELSIKVDKSVLKEFDEKFVEKVHGKMKEQKMEDKSVAFQAPTFVANRGIGVNTEESSRAAELIARELASQDNVGIRNNEILDSVDTVRSQSVPTEFQNSAYVPRTVQTQGAPIQQLPAPVQSQYYPVTSYSGGGGAGGSWCPSFFCFSADTLVQTIDGNLKPISELEVGKDWVLSRNKTDIVYSQVTEWIHKDDNQEAEFIKISLDDGKELKITAYHYIYKTECTSDRNEESLRVDDVEKKAVYAKDVNVGDCLYVISTDKNTVSKKEVTAIDTVTEVGIYAPMTGTGDIVVEGILASCENIIHNNVMRSSFYQSFKYFADFIPNLISRKDESNTVDLPYGLELAIQMMNTVMPKEIFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLQ3</accession>
    <name>A0A0N5BLQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000684900.1">
        <property type="protein sequence ID" value="SPAL_0000684900.1"/>
        <property type="gene ID" value="SPAL_0000684900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="149"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000684900.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33470" checksum="DDA99260CFDA5639" modified="2015-12-09" version="1">MYATSKQMVDEILRDHTMVNPRHLLITKISSISNIETYFPERQKYRNVSTGKYETRISPYLITEYYIKNNFKFICNGKTFDSYSNALSYVMKVKRNDHSLSMRRPSMNVPPSIDINNLENQIIYCRKFWLVLWKSCNYYCYSSNNFKIMKQKFLLELKYYREKYGAKPLVENSYLSNSALNLLTQAVSMRKKIDITKLENIGKGTLVDAPLILNKWFGEHKFFTNKDLGSPKTKHFIAMVWKSARNVGIAIMRADNEIYVKLIYDKKVNIPNIQNEIIFKNYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLS9</accession>
    <name>A0A0N5BLS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLS9"/>
    <dbReference type="WBParaSite" id="SPAL_0000687500.1">
        <property type="protein sequence ID" value="SPAL_0000687500.1"/>
        <property type="gene ID" value="SPAL_0000687500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000687500.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29085" checksum="50281BF47916CFD9" modified="2015-12-09" version="1">MSTKNIKLEKYQNNNLDSKKNFVTSTPIKAKEKMLSSLSTTTSSSSESLNLSLISTAHQPKASSETDVELDESQLSLSMIANLTTTYIHPKNNLIIKEINENSSLNATEIYDGTFYIMTKTFNEKKHAYFFDSYCNTSFGYIKTRCERITKAKTVFTANLLGIQSIVSFISKNGLKSICIYTQNNEFKNELVDTSRKLNTTEIQIYSLIKKQVASGRKITLCVLNRLIISEMERLKLHVNSRNENDLSIQDTFSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM30</accession>
    <name>A0A0N5BM30_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM30"/>
    <dbReference type="STRING" id="174720.A0A0N5BM30"/>
    <dbReference type="WBParaSite" id="SPAL_0000697500.1">
        <property type="protein sequence ID" value="SPAL_0000697500.1"/>
        <property type="gene ID" value="SPAL_0000697500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000697500.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="23770" checksum="BB5E35FB22E838C4" modified="2015-12-09" version="1">MPDGSNELRKTQLKELALLNGTLRSEEMLVKTFCGNCGGEGHKTYECMLAQNVTAAVVCTACGANGHIARDCKNPLPGGVVVDEEYQALMNQLNEANVDPSTYVMYAQQGLVTPTAPATASPGQFPPAGGSLATNYPGYTPNQNQQIAPGFGFVQNNPQNATAATYPQPPIDMSMFYAPPPPPPPSSGSVMMGYGDSTGGLDSIESMKQAALAYAARQTAANDDEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMX4</accession>
    <name>A0A0N5BMX4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMX4"/>
    <dbReference type="STRING" id="174720.A0A0N5BMX4"/>
    <dbReference type="WBParaSite" id="SPAL_0000725700.1">
        <property type="protein sequence ID" value="SPAL_0000725700.1"/>
        <property type="gene ID" value="SPAL_0000725700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000725700.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="54343" checksum="0C30AAB456CDEA41" modified="2015-12-09" version="1">MEAESMMRKKEYLLGMCYDIKILSNEKHCFLYFDSMVKMNMKRDKEIIKSDSNVLIKPFKNDLDCKKLVEGDKAYIDKVKKKRIVYKENNIPMDCESIYKRGFNKNKILSTIEKKYSLAFASNVYKNYEVIELKLLLTYSPNNHYCYMIDSKSPKLYHQMIQLEKCLPNVYVPKIQYDMKSNGENTSISHFQCMKRLLKTKFDYVFLLQNDEMPLKTNRELVEILETMNFAMDMNIVIDKPLINNRFDHKKSWKFKDLNIFLDGDIRKKNTTIMNQEIEFTKGLITTGLPRDSVDYLVNKLNITTFLNQLNTHLYGNDELSWQTLLSSDILNVPGHVPRKHIMNYFPEPYYLSKLVVWAPEPCPTGSYHHTICSWGVETVKDLLNVKHYFLYRFREEFDYGAMMCYGEYLYNKTNFDEYERPDLWFYYNSPLSIYKRLSLTHNMSLIDDYKRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMY0</accession>
    <name>A0A0N5BMY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMY0"/>
    <dbReference type="STRING" id="174720.A0A0N5BMY0"/>
    <dbReference type="WBParaSite" id="SPAL_0000726300.1">
        <property type="protein sequence ID" value="SPAL_0000726300.1"/>
        <property type="gene ID" value="SPAL_0000726300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000726300.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22224" checksum="D31AEB85CD33525A" modified="2015-12-09" version="1">MNSIFKRRSVTFADHPEILKYEIDENYSPKFEVRVPFYRKCNDDDFEEKVRSVTLRRCPSTKTGNDIRKRFSISGPVFDSSILIDRRHTFCHDDTPKRSSYFDTNNNNTNPKETTPHYDQPRYIKNRLQPTPFHMTKHVTECISEFQTCLDKLLSARHILANDTSLPKECTDYLLQAIEKVSGNARNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN29</accession>
    <name>A0A0N5BN29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN29"/>
    <dbReference type="STRING" id="174720.A0A0N5BN29"/>
    <dbReference type="WBParaSite" id="SPAL_0000730900.1">
        <property type="protein sequence ID" value="SPAL_0000730900.1"/>
        <property type="gene ID" value="SPAL_0000730900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000052">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000086">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF8">
        <property type="entry name" value="ASPARTIC PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894637" evidence="7">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="65"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000730900.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="41911" checksum="AEDC73287D69531C" modified="2015-12-09" version="1">MKSLLAIVLCLAIANAAVVEVPFRRAGSMRARMIKDGSWKSYVENNWKVRAVGSQPFIDYYDDFYIGNITLGTPAQTFEVVLDTGSSNLWVIDSKCNTDACKGYPNSGYTKHRFDTAKSSTYKTESKKFSIQYGSGSCDGHLAKDTLTMGGLTVKTQELGVATTIAEVFGYQPVDGILGLGWPALSVDNVVPPMQNLLSQLSSGLFTVSLNLVPNPSSVSGSSNGGTITYGGLDTKNCKGAISYVPLSSETYWQFPIEGFTIGSFSETRKQQVISDTGTSWIGAPTSYMSKIASTLGAEYDWSNELYTLPCTGTYPDMVFTIGGKKYNIPSKQYVLDLGLGGGNCALAAFDMGGMGGPQWILGDVFIRQYCNIYDISNKRIGFQLSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN86</accession>
    <name>A0A0N5BN86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN86"/>
    <dbReference type="WBParaSite" id="SPAL_0000736500.1">
        <property type="protein sequence ID" value="SPAL_0000736500.1"/>
        <property type="gene ID" value="SPAL_0000736500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000736500.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16832" checksum="8ED93615492299AF" modified="2015-12-09" version="1">MSIQCKQTNDAGLPLIVEGKKSEYYFDKSPNKLHKKSSYYLKNASKGVSEYLLSDLRMHNPYILHGGASFTNIHAVVNDKYHIESDDNINVIGKLMTVDKLTKQIHNLSNGFYCPIIRNGELFFVSEDDNIKTAIDIDTKSPVKEYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP24</accession>
    <name>A0A0N5BP24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP24"/>
    <dbReference type="STRING" id="174720.A0A0N5BP24"/>
    <dbReference type="WBParaSite" id="SPAL_0000765200.1">
        <property type="protein sequence ID" value="SPAL_0000765200.1"/>
        <property type="gene ID" value="SPAL_0000765200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="10">
        <location>
            <begin position="246"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000765200.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="72414" checksum="741B8BB676CBAED4" modified="2015-12-09" version="1">MPTKYNLELKIFIPSYNDFKTKNDFLFEGIISIYLKTRKPTDIIALNVANSSYVIPNFKNMIISDTINKKNNLTTIKNIEYNNKKEIMNFYLNRTLKINETIIFSFEYKGYLNKHENVGIFINKTISKSPNDDVKLYVASHNQPGYARRFIPCLDEPNYKSVWNVSIIHPKPTKAVGNGSPLAEEEIEGGWMKTRFTPTHKMSSYLFALFVSEFEYVEKEVTHTNIRLWFDPVYRDKAEIILFLNEEILVFLEHYFDYAYQMNHLDIVAVPHFNVEAMENWGLIMFKSKILFYPDDNDKKKEELKLITITHELVHQWIGNLITPEWWQQVWLTEGVTQLITEIVVGKLYKQNFSHQLFIRARRGMFNDFNKTYDLKLEDNFDDVHNYKNHFNIAYSKGYGVTNMVYQIMGYDLFREAMILYVKHNKFTNVNSTILFQRFQKIANDNGFGDHIDFNLMRKEWVLQKGIPLVDVKRINNNTIELTQQPFDVRDDNRSGYKPFNEKFRCTWNIPIWYTLNGILQKMEWLQNRLTLSVNSTDIYIINPETRGWYLVRYEKDYYKILKNKFNITTTPYRNYMSILCDAVWLCVEKYTDCQTGFESQSCVVKAPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ13</accession>
    <name>A0A0N5BQ13_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ13"/>
    <dbReference type="WBParaSite" id="SPAL_0000798750.1">
        <property type="protein sequence ID" value="SPAL_0000798750.1"/>
        <property type="gene ID" value="SPAL_0000798750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000798750.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10962" checksum="B0877DE420479733" modified="2015-12-09" version="1">MKNITVPESKACHEILKAYRGIGRYYTEGSFYYREIYSKVLTNKIYNSYVSPDKGALFYIGDCACTDYTCTSFKAVCIYTYWFGWKVYGNHSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQB3</accession>
    <name>A0A0N5BQB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQB3"/>
    <dbReference type="STRING" id="174720.A0A0N5BQB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000808000.1">
        <property type="protein sequence ID" value="SPAL_0000808000.1"/>
        <property type="gene ID" value="SPAL_0000808000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894702" evidence="1">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="4">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="3">
        <location>
            <begin position="223"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="333"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000808000.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="51381" checksum="BBB0943677607701" modified="2015-12-09" version="1">MYFIAVVLALVELSIYSHGHTHRYLFPGISRNPKDYESPHGLTIYSRSDTIALKCPYEGYQHYTDEDTFHDFESHEMLFKPDVGTLVKWKILTTNSLGETVSFSCGYLKTYEQKQTSNDTIKEQVIIHWSYRAKWENAPNTGKITTEEKQYAYKESIPDKCNSPIRDLIIVEKISELKAQILDVSETKRAPNDKLFYFFTKSDEEDKTMYKEPCLVLSASNFCPQITILDLEYITVPYKDDQILVFKLDEDKETTFDIRLNLQIGGRSLGYYNMDNVSITRMLYLEGTIDYAPMYSDYSDSTFTIFGYELVKLEYYCRDEEYEIPKSRLLFFGPKDDNLQLEERIYRYYDHDKRLQPNCTTDRMPYAFLKEMYCNGEKIKLDDLEYSNSTNFIVKRSRNFIILENVVDRAAVVKCVYRTPNGTITSNDQFVREYLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQH9</accession>
    <name>A0A0N5BQH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000814500.1">
        <property type="protein sequence ID" value="SPAL_0000814500.1"/>
        <property type="gene ID" value="SPAL_0000814500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000814500.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37024" checksum="B1466925D2ECDB25" modified="2015-12-09" version="1">MITTVDIIQFSYFVPSIILLIIFVIRLTNEMLIKRNPIYNNNFFPLILFKSYSDIILMISMFFCSRAAKMNIMGDFYKENYGIAMYYYVILEICHTNIYGVSLLSSLNTFIALVYPLKYNIWFSKKKIVICLTITVLVGLIYGIALTFFHPYYKYLKSKKGYFVTFKSSDLIYCIIVYVIVINIPIFALSTIMNIISSVKFAKYYKTMNVKNSQNISMFVYTIINFFTYLIVVAYSLGKIINFVTVESDLVDIIAQEISYWNVDLMTFGLFYTVLFLCSPLRDLLHFKSKKETSLNNFSSNTSKKGGLKTQQNKSLNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQI9</accession>
    <name>A0A0N5BQI9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQI9"/>
    <dbReference type="STRING" id="174720.A0A0N5BQI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000815300.1">
        <property type="protein sequence ID" value="SPAL_0000815300.1"/>
        <property type="gene ID" value="SPAL_0000815300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000815300.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31143" checksum="9455E8D3397D36AF" modified="2015-12-09" version="1">MRLTSSGLAMSPEKLRKVMDFLIPQNKKTLLSFLGLANFLRRFLKNYTIDSKPLYNLSIQPTFTWTEQALESFQKVKKSLLEAPILTAPNFAKALDESWPFFLVTDASEIGIGAVLLQKMNGDMKIIAMFNRSLHGTISAALTHMNLILYGVPVTIITDHQCLTYIFSKPNLSTRLNKWKPHMQQYRIKTIKYMEGKSNFIADCLSRCLKVVETGNAEQFPAIQICSINRSFNWDFFSSRPEWQELQQRDEHIQLLYTFLDGTNKSNDITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQQ6</accession>
    <name>A0A0N5BQQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQQ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BQQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000821800.1">
        <property type="protein sequence ID" value="SPAL_0000821800.1"/>
        <property type="gene ID" value="SPAL_0000821800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF217">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="6"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000821800.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45689" checksum="401D3B4CF20E2384" modified="2015-12-09" version="1">MDNKECFINFLKGMIGPGVLSLPTSFKDAGLIPAFIMIIVLGITNTYCMIQLVECSKYYTMKYKLKTIDYGALAYYSSKEFMKSDTMLTKIFPIIVWTCLLSLQIGICSVFYVFVGTLSKELIENTTYISTKYDIRLYYIGYLLPFLILGSFKSIRILTILNLFANILLGLSLLSIFLVLVLSKHSFSEIKYYTNINGFFTALGTIMYAFEGQALVIPLTNHMKESNSMINILIWGMTIIIIIAECSGVLGYLTYGNKVASSITINLEDSKLLLFIKIIFMIVIFISYLIQMFVPIDMALPYVKMIVKREYQNKNYLESILRIFFVILTSIISILIPNLKSIISIIGVTCGMILALVCPPIIRTFTFFTLTKSALKIIIIDSCIVLLGCIGIIFGLTSTIKDMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQR2</accession>
    <name>A0A0N5BQR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine incorporator 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQR2"/>
    <dbReference type="STRING" id="174720.A0A0N5BQR2"/>
    <dbReference type="WBParaSite" id="SPAL_0000822400.1">
        <property type="protein sequence ID" value="SPAL_0000822400.1"/>
        <property type="gene ID" value="SPAL_0000822400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000822400.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="48729" checksum="58FE7B6091F3F641" modified="2015-12-09" version="1">MGALLAAPMCAAQMACCCGATACSLCCSCLPASKSSTTTRIMYVLMLLVGTIVSAIMLAPAIQEKLDKSSWFCHGLGVDCKAVTGYQAVYRLCAALATFFGFLSVLMIGVKSSKDPRAGIQNGFWFFKYLLVCGIAVGYFMITSKSFSEPMMVIGMIGGCLFILIQLILIIDFAHGLAVYMINSYEDSDSSRTWAFLLYGFVILNYGICIVGAVFMYKNYGGEGCVLPKFAITFNIILSLCVSVISILPKVQEHFPHSGLLQSSFMSMYTIYLTWSSLTNNPNKSCNPSIQQLLGTSSEVPSSYATPIPVESLVSLFIFMACLLYSAIRTTSNTAMGAITGGGNQNSEGDLIPLSSSNGNDVEGGQVYDNEKESVSYSYSYCHFIFALASLYIMMTMTSWYSPDNDITHLNSNTASVWVKLTSSWVAILLYTWTMIAPAIFPDREFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQX9</accession>
    <name>A0A0N5BQX9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQX9"/>
    <dbReference type="STRING" id="174720.A0A0N5BQX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000828700.1">
        <property type="protein sequence ID" value="SPAL_0000828700.1"/>
        <property type="gene ID" value="SPAL_0000828700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="124"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000828700.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40667" checksum="DD2535B59BEE488A" modified="2015-12-09" version="1">MATTTRSQRKRAHTIEEDFQTESPLPKVPSNKDLNSQSEASDEDVITNPNFNRNSSLLITPIDDYIKDRTRENVSGLPLALNSPAPYSDEEAAILEREKIDYSKKITLEMAMNNTAGRPVRVFADGIYDLFHHGHANQLRQCKNAFPNVYLIVGVCGDESTHKYKGKTVTSEEERYEAVRHCRYVDEVYRNSPWYVTVDFLKELKVDFIAHDAIPYVAPGEEDLYEKFRKEEMFIETQRTEGVSTSDVVCRIIRDYDKYVRRNLARGYSAKELNVGFVAATKYQIQNSVDQIKQKSAEVLNGWKNRSDEIIRGFISTFHPDGGLHYVTDKIRDLVSRSPSPAFEETESNHSDDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRA2</accession>
    <name>A0A0N5BRA2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trimethyllysine dioxygenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRA2"/>
    <dbReference type="STRING" id="174720.A0A0N5BRA2"/>
    <dbReference type="WBParaSite" id="SPAL_0000840500.1">
        <property type="protein sequence ID" value="SPAL_0000840500.1"/>
        <property type="gene ID" value="SPAL_0000840500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="150"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000840500.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="48154" checksum="1E07DFB02DA5D5A8" modified="2015-12-09" version="1">MFIIRGYTTSRRFLSTTNIFLKNINSLNIIDNRRGLQLEKDDGQNIRIPLIWLRDHCKSKESYNWSTFQKNVSLNDLWKQSEVTNDSDIKLNKENQKLYIKWSDGHKSEYDINSILKSHKYKNNQIPEKILWNKKTFLSNSKPLSYKNLNLKEFYKEFFKYGLVFVNDVPYDDPKHTEELCKKIACIQNTLFGDFWVFSNNTTTESHADTAYTSLPIGLHTDCTYFKHSPGIQVLHCLHKAKSGGENILTDGMYCAQKLNKKYPTYFQFLSSNKFYHHYKELPRDRGNGTGYHSINNCKIIETSNGEVKQISFNPYDRMDLTIGEGEDDYDKLMMFYQSYIKFNEILSDDENKLVLTLNPGTVMFMDNRRVLHARKEFEGKRVMCGAYLNYDDLEARANSLFEGDKIEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS81</accession>
    <name>A0A0N5BS81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS81"/>
    <dbReference type="WBParaSite" id="SPAL_0000872600.1">
        <property type="protein sequence ID" value="SPAL_0000872600.1"/>
        <property type="gene ID" value="SPAL_0000872600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000872600.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29892" checksum="EFDB3919EFCF7D08" modified="2015-12-09" version="1">MGLALGLVPEITRNDRKFNVNVTFKNIKSTHLKYYKVQNYESKVLGNTSFDFYSKMLSRQFFGSKNGKETYNSESPLFKYYRETKNLTAYFDYNDFKRLWFLHCDMCGQKEGCSNNGYFRLDCNKCECPIPFAGNRCRHIYYNDLSKCGTQQEYIATSKWNRNTINITDAFCYYVIKSTTGKKVQVNLLEFSLSNRKDCPQKSGLEVKYRKDKGAGGLRSCTNYNETIYLPALTSELHFIFSEKGNNELKFSYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTT8</accession>
    <name>A0A0N5BTT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cg7 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTT8"/>
    <dbReference type="WBParaSite" id="SPAL_0000926300.1">
        <property type="protein sequence ID" value="SPAL_0000926300.1"/>
        <property type="gene ID" value="SPAL_0000926300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894842" evidence="1">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000926300.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22846" checksum="D6D4488BB4FA4B52" modified="2015-12-09" version="1">MHFFCLLYFSFLQYFLINVSGRYLDTKPIIKTFILHRIVDGDHKCEENNSVLNNTIYYKPYFFTYSNLHRQLVNYYYIENNKTFSLNDISEPIFYETIVRYLKFDCDVSRNIKCAIKPDIVALKFFNSGKKYIQNIEVVLKRTITSTEGETKTLFEISTFPVDKCIDVVPGMYYVFGPEKDFFYVTREEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU47</accession>
    <name>A0A0N5BU47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU47"/>
    <dbReference type="STRING" id="174720.A0A0N5BU47"/>
    <dbReference type="WBParaSite" id="SPAL_0000937000.1">
        <property type="protein sequence ID" value="SPAL_0000937000.1"/>
        <property type="gene ID" value="SPAL_0000937000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045005">
        <property type="entry name" value="BPM1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379">
        <property type="entry name" value="BTB/POZ AND MATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379:SF187">
        <property type="entry name" value="OS07G0655300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="369"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000937000.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49623" checksum="57115CE773A68BD4" modified="2015-12-09" version="1">MGQEISKPFNGFNLLQAGDNNFKYKYTIENFSFRHEKTGEGIISPTFVIGSKERSEWCLQIYPNGATEENKGYVSVYLVLKKPNKAKAKCRFSILNDKEEEKNVCDCKEAYEFDRNSVNYGLGFSKFVNRDLLLDESNGFLFNDMLTILCEAEITDLKYENSIPYDVFYTSQTGVNYFKYIYTIENFSLRSEKAGEKIISPTFVIGGKERSEWCLNIYPNGLSEDLKGYVSVYLTLSKPNKAKAKYRFSILSDKGEEKNVRFVTESEDFVNNEKESEDFVNNEKGSGFSHFVKRDFLLNESNGLLVNGCLVIFCEAEIIYLKTENHDNLEIVDSKTENRDNPETSMNILNPQSKLSLDYGNLYDSPLFYDCVVKVEDIEIQVHKAILAARSPAFYGIFNSTSEESQTNIIEIKDFSIEVVKEMLKYIYTDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUX9</accession>
    <name>A0A0N5BUX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUX9"/>
    <dbReference type="STRING" id="174720.A0A0N5BUX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000964700.1">
        <property type="protein sequence ID" value="SPAL_0000964700.1"/>
        <property type="gene ID" value="SPAL_0000964700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF279">
        <property type="entry name" value="SODIUM-DEPENDENT SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="475"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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            <position position="476"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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    </evidence>
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        <source>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
    <sequence length="701" mass="78579" checksum="6562C9A55DA0FCCD" modified="2015-12-09" version="1">MLRWVSIRRARKTKTPGDPSEYQDSPGIWRNNKIPEIVTDMSLTVDGPPGINTSTRSEGYHSLDEKLSNEDGSLMISNKHDPTAVYNTINNSLKPPQSSSTNANRRHSLLVPREQWNNKMEFLLAVIGYAVDLGNIWRFPSICYKYGGGAFLIPYLIMLLVGGLPMFYLELLLGQYHRSGCISIWKGLCPLFKGIGYGICIISTIMACFYNAIIAQAVYFAFASISSLEVPWKRCGNPWNTPLCRDDTMPMDSINKNVTTFHRTASQEYYIYNVLESHKSSGFDDLNGIKMELAGCLAVVFFTVYFALWKGPKSSGKFVWITATAPYIVLFILLIRGITLPGASKGIAYYLTPNFSTLQDPEVWTAAATQIFFSLGPGFGVLLALSSYNDFHNNCYRDAVVTSIVNCLTSFFSGFVIFSTLGYMSEITNTPVSEVVGAGESSLIFIVYPQALATMSYSNLWSLIFFIMLITLGIDSTFAGIEAFITGFCDEFPRFIGRRRELFVAVVIFFFFFGSLPTVTYGGSFVIPFLDSYGVSLSLLFIVMMEMIVVCWFYGIDKFSENVREMLGFYPGRYWRTCWVCCPVFIGIIFSLAVYNTNFKPMVDGDYTYPQWSVYLGWGIRLLSVLAIPVYGIVLIIKTPGSLSTRLRLALTPQKKRDSRRLSVCPSNVSKQSIIQLNGNTVITTTAKSSIDDDKFNKIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV63</accession>
    <name>A0A0N5BV63_STREA</name>
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        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV63"/>
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        <property type="protein sequence ID" value="SPAL_0000972800.1"/>
        <property type="gene ID" value="SPAL_0000972800"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
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        <property type="entry name" value="Lectin_C"/>
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    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894975" evidence="1">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000972800.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35858" checksum="3A2E3810F49AED68" modified="2015-12-09" version="1">MIVYLLFLLLSLQRIISEYCPKSEEFILSQDNKCFKLYDGTIGFENISQSCNNNKGILSGFINNNETRDVLQLLKNHYKDLNATYIDRGFTCRNKKEPCLMNRNKNEGILNNVTYLTDKFPCRGVMRIRDLTFFCIDMSIKTDIVYACQKNPLYIKNCTSYNGYDKYIDGNCYKLLEKIDFTKKTAEIMCKDNSGTLPIITNDFENLAANQLLDKHKSQFWLDFSCPTKNVSSCRWSTNKEMIYQKLESCPTKNVSSCRWSTNKEMIYKKLEKLNDDNLCGHMKKPGIWDTDHCDKKKKVICQIRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV69</accession>
    <name>A0A0N5BV69_STREA</name>
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        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV69"/>
    <dbReference type="STRING" id="174720.A0A0N5BV69"/>
    <dbReference type="WBParaSite" id="SPAL_0000973400.1">
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        <property type="gene ID" value="SPAL_0000973400"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF24">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894904" evidence="2">
        <location>
            <begin position="24"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="521"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000973400.1"/>
        </source>
    </evidence>
    <sequence length="912" mass="107753" checksum="1317F75F612E3DCC" modified="2015-12-09" version="1">MVILNGIIIILIFTCKFISPAVSTPSGDVLSSTEEIENKDKQLLEKYNLETDSDIIFIKCPLTNYSEYQNYTLFSNQNDNTFQIFEDSSKKFNWYLIERKKHMNASNYYCKQDNGLLVKNEFEWIIEINWKKAKQNVEKKIFINKNILTKLCNVSNVIQIFYINIKGALTEGCPNLNQFYKSQLLYMFNFTEKEESKYLVPYKILNFYFKAPNIIIEGEVKLNNQNSIKFFFVKKDFETKRFNVKLKTDNEFSNFYHNENVIFSVGKYDVNKKLIFSKMKKLMNNSFDIVGYGIYQLGYICDKCQEGDNVTVKKTYYFGPKKTIVNKIINNVNNEDLSYKANCSRNLYKFAYLEKASFNGIHVDIKNNSKLVSKDLQQFSINSSHLTIAKNNPRGILKCYYKTPTSYIIKNENFNVISKMGRKDLKHDDKNSVIKKVSQLNKNPKTSKSSNSTLIYICCLIGVMLLIILIICYIKKDSIKNSIKRRKMMKKYPNIYNWWNILKNSQPNEYGKVIVNTNFFENQIKNYGIRQVTFGGDTIKQLNETNVEYKLVKSQNNLPYIIMASHIELKDIKSKFIISNYPYEENFPHFWRMIYEEGITSVVAIIHENVHSKIKDFKYYFKIEKASYDNCEINLLKVKNTIFPTINVIEYSISMNNKNPKIVNIYHVYDWMENSLLETNIEIDKLYKHIIDNNSKPTILVHSHVSPCSRVYSFIYFGTVLETMEKNKKISSPMVVINEIREQRNGGYISIQDYSVIMFNLVNYWVEKELLVIKHYYTKYVQEYSKYRFDERRSEAIFSGNCRPFVCFAIQLSRNSIYEMLHQSQYIYKLDSKTIKTKCRRFYQIQKNSLLNFKNRFPDIPCYDFKSINYDTVQNPTDDINNYYHGNIIEYKTTSGMKRSIIMCQVKTKFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVH3</accession>
    <name>A0A0N5BVH3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVH3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVH3"/>
    <dbReference type="WBParaSite" id="SPAL_0000983100.1">
        <property type="protein sequence ID" value="SPAL_0000983100.1"/>
        <property type="gene ID" value="SPAL_0000983100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000983100.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20735" checksum="0D990B4C12485C8C" modified="2015-12-09" version="1">MASTEVNLSDRMKVLSLDTKDGEEYKYISNFSEKILIEVQNIVSKYLSEPYSIYTYRYFLIKWPELCIACMKGNKLIGAIVCKEEMIENGRKEGYIGMLAVEPNYRGQGIGSKLVEKAIEKMKENGCDEVTLETEVTNEGALALYTRFGFIKLQKLFRYYLNGVDAFRLKLFLTNPLKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVH7</accession>
    <name>A0A0N5BVH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVH7"/>
    <dbReference type="WBParaSite" id="SPAL_0000983500.1">
        <property type="protein sequence ID" value="SPAL_0000983500.1"/>
        <property type="gene ID" value="SPAL_0000983500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895057" evidence="5">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000983500.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15930" checksum="0F33D085A0283ADC" modified="2015-12-09" version="1">MSSIITYITIAILLTLPLTQGIGRTQAAGAKGYLTCNGRPASGVRVKMYDDDSGIDTDDFMAETTTDSSGYFSLSGTKSELLTIDAKINIYHNCNDNVIQKLCNRKFTMWIPDSYINSGTSVSKYYDIGKIELAGKISGESRDCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVL7</accession>
    <name>A0A0N5BVL7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BVL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000987300.1">
        <property type="protein sequence ID" value="SPAL_0000987300.1"/>
        <property type="gene ID" value="SPAL_0000987300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF17">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="430"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000987300.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="62460" checksum="37D606C4771A25C9" modified="2015-12-09" version="1">MMGVLQDILDKMYVEPELLAGLDDIDKQRLFKQMREEQVRRYNENELLYEKLIREGVIKKDPPSKRVQWKNREDGDVYTYIFGEDEPEKKLHDSEYHRDNDINIHEKELMFDKLLKFNNNESENLNEEQLKRQLGEMEIGPEFVKEYNPQNQFSLQPAAQLLFNLPNVNGKVAAAKLAFENNNKQSQSLLYDNNIHIGTKVNSNNSDIIQSIQNNKVIIPVPESNTKPDVLPEQNPIGVKDLLNQFENLPYQNGHSNAINTTPTITPQNMSQSFPVSNGKLPVVNTNSIVANAKAKLSIFDPEINNRQNVLFEKLKQDREVLRNDSFSDSEKHLKESDDQDNNIKQTGQRMKEIAIKAREAHRKQELRTSSPLLNIVNGFDKNMTFREAIKKIPRPPKPESRNAIIKWFKEKEIPNSTVIDPLTKRPAVWFHGIISRETAEKLLNKTKWGSFLVRVSERIWGYTVSYSFGNGKYKHFLVERINQGYQFLGTNQIVHYSLYDLVQHHFTSPVTSNGNEILKFAIGQNNKIPDYYELFDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVW9</accession>
    <name>A0A0N5BVW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVW9"/>
    <dbReference type="WBParaSite" id="SPAL_0000997500.1">
        <property type="protein sequence ID" value="SPAL_0000997500.1"/>
        <property type="gene ID" value="SPAL_0000997500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894926" evidence="5">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000997500.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16440" checksum="D3821B0760FF4359" modified="2015-12-09" version="1">MYHFLLLFLLANFYTINGRVQTISIGGRFLCLGKPVPFHNVILKEADFFTDDTLAVSATDKDGYFFLMGMDDEVLPITPYIESTFACCEPGKECKPQKERLDIPFGQLSIFQNQNVFNFGDIEMFGITSNRIIFQNYGREGYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWW3</accession>
    <name>A0A0N5BWW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWW3"/>
    <dbReference type="WBParaSite" id="SPAL_0001030200.1">
        <property type="protein sequence ID" value="SPAL_0001030200.1"/>
        <property type="gene ID" value="SPAL_0001030200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018251">
        <property type="entry name" value="Crust_neurhormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01250">
        <property type="entry name" value="CHH_MIH_GIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001030200.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8152" checksum="F19FE48D958CB9C5" modified="2015-12-09" version="1">MIITYFKFNNTEYKNMLELLCIQCHELFSYSSPNLRAQCRTNCFDNSTFMKCLEIFEHHNNKRSLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXB6</accession>
    <name>A0A0N5BXB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXB6"/>
    <dbReference type="STRING" id="174720.A0A0N5BXB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001044800.1">
        <property type="protein sequence ID" value="SPAL_0001044800.1"/>
        <property type="gene ID" value="SPAL_0001044800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007026">
        <property type="entry name" value="CC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF92">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04942">
        <property type="entry name" value="CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895271" evidence="2">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001044800.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23986" checksum="0DFCD0AA0067FAF9" modified="2015-12-09" version="1">MKYYSLVFLLSVATLLHGCSDSDPDCDKKIKYCNDTNYQPLMEKYCPLTCNFCTTATPLPTYGPCVMGECPVGFSCTNNVCMPTTISTTPGYNCIDHADNCEAIKDYCTNPSYLPLMQENCAKTCGFCQSGVMTTTTTAPISTTQSPTGPCVFGSCPIGNTCINNLCYPMPYSSSPITTTTVPSCVDWATNCQQLKDYCMNSSYKDIMKEQCAKTCGYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXZ8</accession>
    <name>A0A0N5BXZ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Defensin-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXZ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001066100.1">
        <property type="protein sequence ID" value="SPAL_0001066100.1"/>
        <property type="gene ID" value="SPAL_0001066100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001066100.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9314" checksum="5DD03D9CBA1A43EF" modified="2015-12-09" version="1">MFPEGIRYIIVINNMKIIFISVILTFILFIHEVNCSDSIILDPCDEASCSAHCAFEGKTNGHCIKVVKNRNKRSIGLSECHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ60</accession>
    <name>A0A0N5BZ60_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ60"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ60"/>
    <dbReference type="WBParaSite" id="SPAL_0001105500.1">
        <property type="protein sequence ID" value="SPAL_0001105500.1"/>
        <property type="gene ID" value="SPAL_0001105500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="234"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001105500.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="65286" checksum="7DACED03C314A6FA" modified="2015-12-09" version="1">MQHNTVVPQVKISDQPFLVTNTDQLNKIEWTMLGTTASETIYCVSEHPVSQLRFVCVECLQKNITDIVNVLNSAQDLTRKSGFPTIALQNVPAKANWTGVTIVCQAALNGGTIDSAPAEVNVRYIRQPHVVDRNGMGPVLIANQGYRFYVECIRGQDGQCQQSVGRGKTLRCAVQAHPTPTIYKWFKNGIEISGNSAEITIGVEMIRQSIQCAANNGLHNENDMPQSQAVQIDPYTAARVVQDNFQNIQTSSPFQPGNRIDMNQVVNLGCQVEGNPRPIVFWKQRKINGEIVDAPCPQGFDGNYKEIPGDSGRDITYNNNAVKLSAVCNLHVSNYSFSGQYWCTACSYVSQGPPECSPNSDTPPSSVLNIQVQGPPMLSEQQPSVQKSQNGEDVVITVHYCSDPMPRPPREVIFTIDQNDIQVGQSWQNFRFEGTTQNNTVPNCYFAKLQINPIKESDERRQIKLSVQNAYGKIDIPVPLSILLGTNNGFSNGLSDWIIVIIILLAVCLGTSLIILICMRQRLLCFDKLNDVDNKYSRDNKQQNDFQIQHEYPDSHSMPHNLFGSQTGEALYEAAVHAAYNDSRISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZC2</accession>
    <name>A0A0N5BZC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZC2"/>
    <dbReference type="WBParaSite" id="SPAL_0001111500.1">
        <property type="protein sequence ID" value="SPAL_0001111500.1"/>
        <property type="gene ID" value="SPAL_0001111500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="301"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001111500.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50210" checksum="A14EFD0202D0BC7E" modified="2015-12-09" version="1">MRYYILFLPSISILLPQNPPTMPSKRGSYVKKISPPLLPAKQYNYVMPNEHEVIRPQSIVHYEVKLYHSKIGSIFYECNGVTFPNQLQAEKYCLMLNNYELKKAKQNQQHRTSINKNHRNSLLRSNSDLSNKKKTILRVSGSLTERKHSSSGSRNSLLGLSRSSSSQSLAESSKHLTLVRNGVSGSNNGLSSRRGSAFGSNNDLSSGGDSGFGSTKDLSSRRNSISGSTNDLSGKIRSSSLERRNSLSSSREILKNKVIDNEIYEESFDKKIKKKSKSYQIWLKVWKNCNFKCISENYYDGYRQHALLEMNMYRLHHGVNILELSPKLTEIAQELVEQYLITQALDTKLYTNYGILYGKSTIISASTIIKHFYETNAKYSFYFNKPNSEAAYSFAQIVWKSTTQLGIGVQHDSGYLFVVCVFYPKGNKKKEYGKNVYRWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZM0</accession>
    <name>A0A0N5BZM0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZM0"/>
    <dbReference type="WBParaSite" id="SPAL_0001121100.1">
        <property type="protein sequence ID" value="SPAL_0001121100.1"/>
        <property type="gene ID" value="SPAL_0001121100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001121100.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18342" checksum="582FD9DABF4A2CF5" modified="2015-12-09" version="1">MKVTRGNLKSLTRKIIEENDYEGLLVIATFNIVNVKINGYILEEIHKISDLGSFRETFECEVKVMRKAIEVDIFNTQKLHLLSDSNGFFHVPYEESKEDNIIKMPVSTDSTPSNFSSASLLSTPTPIRRTENLVNTNSRKRRSLDNTCNLLLNKNSLLHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C012</accession>
    <name>A0A0N5C012_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C012"/>
    <dbReference type="WBParaSite" id="SPAL_0001134900.1">
        <property type="protein sequence ID" value="SPAL_0001134900.1"/>
        <property type="gene ID" value="SPAL_0001134900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF862">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895111" evidence="6">
        <location>
            <begin position="27"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001134900.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="58169" checksum="2953C2F21058E021" modified="2015-12-09" version="1">MGCANILLKLLIALCFYIIVITYAHGSTGKKATKTEPKSKIYKYNVNYCIDDKTNKELNRSNIQTGIDMISKHSCIQFSYNSTCYDYKSKCEQTCTSGCRNYKHSDPIKCKKCFEPFRKCNDCTYECDLWKKKYEKQCKSKTKLKECKKKDSCKKCTDSCKNFEEKYEGCKDDCVEKCLDPFVNCVKKCEEVTLPCKDDCVEKCLDPFFYNRSRTDSDFYFDGSITLNKENVYNMEIDVSCNKRPGCIAKKVLMYLGLIPTVRRTDRDDYITVYDDNINSKYIHQYSKRNNGFLYTEYDYSSIGHFPDNYGAKSGKKTYVRKWLDDSRVFLTGQEIRPVFSDLKWLDIVYCKNHSTTTVKCKNNGYPKSDGSKCECPTGYTGDTCEKLQFTGPLCPDGLIDLKNSTKRHLLALYSKSDCTVKLTAPEGKKIRINVEAVNCTSKNPCFENDCLQIKYNSDMTLTGLCLCGTIRNTSLTTTSNKALIQYTGKNYRNYAFLYYQVVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Q6</accession>
    <name>A0A0N5C0Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZnMc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0001158400.1">
        <property type="protein sequence ID" value="SPAL_0001158400.1"/>
        <property type="gene ID" value="SPAL_0001158400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="42"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001158400.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45353" checksum="2FEB6EA2AC4C6D99" modified="2015-12-09" version="1">MIKFYSFNLIIFLTISFLFTIFCQSTFKSKPHVSSEESERLNSIEGIARFKNKEYIKYSITNGINLKKLKEALKILERNTCLRFKFSSRLRPWNFGLHFLGYMAIRYPNNVPGENELQNVFISNRTSNNIGYLLQQTLLSMGFIPQHQRPDRDSYIKFVEMDAEYRILLEDKYLDKYDANDVNIYDTSYDYGSITEFATNYFSEITSSVMEARKNPIYNRMMGQQYGLSFNDVKLINLAICSDKCPGKKLNCKNNGYLDPLSCEKCRCPNGFDGVTCERVAVTKTHCGETNLLATKDPAELKRKGPGVCNYLITSKKGYKIIIQIVKVEIKRLPRCFEKKGLEIKYRTDFGATGLCICDKYTNFNLTSETNQVLIQYNGDKKDYFKILYSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0R3</accession>
    <name>A0A0N5C0R3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0R3"/>
    <dbReference type="STRING" id="174720.A0A0N5C0R3"/>
    <dbReference type="WBParaSite" id="SPAL_0001159100.1">
        <property type="protein sequence ID" value="SPAL_0001159100.1"/>
        <property type="gene ID" value="SPAL_0001159100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001159100.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="53688" checksum="EB129E54A01E5658" modified="2015-12-09" version="1">MTKTPKMTDPIIIVGGGLAGLSATLEILNHHSNSKVIIFEKQKTFGGNSAKASSGINSCDTPFQKSKSIKDSIDIFKMDTLKAGDNTNDHMLVDYLVQNSKSALDFLIDNGVKIDDVNLCGGHSVPRTHWAHLKDGKPIPIGLAIIKAIQDKILEIKEKRPNDIEIHLDSEVVGLTTWNEYVTGVRYRDPNNRDNIIEVNGKAVILTTGGFSADKSEEDSLLVEYGKHPLLPQLPTTNGDFATGSGVKIARAMGAQLVGMENIQIHPTAFVDPADRDAGTKFLAAEALRGKGAILLNDKGERFANELGRRDYLSEKIFNNCVSEKNNRIAFMIMNDEGVEGFGQQAFNFYWKVKKFFTKVESIEELSKFIGCDKEVLEKTFNEYNKNADEKKDNFGKTVFPTKFDSSKPLYVGMITPAIHYTMGGLKINNEGKVFSDVTNGTIKGLYAAGEVTGGVHGNNRLAGNSLLECVVFGRAAAVSAVSLNYGHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0S4</accession>
    <name>A0A0N5C0S4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0S4"/>
    <dbReference type="STRING" id="174720.A0A0N5C0S4"/>
    <dbReference type="WBParaSite" id="SPAL_0001160200.1">
        <property type="protein sequence ID" value="SPAL_0001160200.1"/>
        <property type="gene ID" value="SPAL_0001160200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001160200.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20836" checksum="0412BAD67FD7484A" modified="2015-12-09" version="1">MALFKLCDSIPDEERSIKFLQEHDLLPSTKICSNGHGMKMVVGKQIRWRCYVKECRKDVGIRVGTWFEGFKLPFRTAILFFYCWSRGLTSIEFCKHELEMNHNTTVDWCNYLREVCLFKEKGHRIKIDGKDVTEDAGETRSMMKEIESEWRRKNKNNAFEALLSDIKLFHCRNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1D2</accession>
    <name>A0A0N5C1D2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1D2"/>
    <dbReference type="STRING" id="174720.A0A0N5C1D2"/>
    <dbReference type="WBParaSite" id="SPAL_0001180700.1">
        <property type="protein sequence ID" value="SPAL_0001180700.1"/>
        <property type="gene ID" value="SPAL_0001180700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001180700.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51240" checksum="501872AD2015B24B" modified="2015-12-09" version="1">MRKFFYIHLKSIIPTCILFGLITIKNLFRAEEFELKLELEYYRNGLQKPIFLGPSKGEIKEHMMFKFNGIDVTQSQSVYKIHLPREYSTDDEYNNELLMSIKTIPNKFDLTDRLQPRPKTYTFHDSNVPKNFLVCNLFKCQIGIVFMRSGDYRSVDSIETRIFFYIGFTKSDEYDNLVLKFIPKVKSDKYIFRVIVCPGASWLSSFSNSEYIETSNNYITKLDWKKNSGRYILKYMYCNENGVTTFVKCGYLKQIYMPSIDVGYECSKNNDKKNISIHNVLKKETNMSSLSSGQLMCDKTVINEPTSLVIDFLPPGNNYNDVNAFKIGRFTINTKLYSGHKLHCVNEEKISQMESEFISSFGHELNYVAKCKVPPLNATLRLKVNGIVQEFKNKTEDNFGKKNIYTFDKREMRDASIGCHAVPDEMEHPAFSDFYELLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1W9</accession>
    <name>A0A0N5C1W9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1W9"/>
    <dbReference type="STRING" id="174720.A0A0N5C1W9"/>
    <dbReference type="WBParaSite" id="SPAL_0001198700.1">
        <property type="protein sequence ID" value="SPAL_0001198700.1"/>
        <property type="gene ID" value="SPAL_0001198700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001198700.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38574" checksum="33D75E74C79565E1" modified="2015-12-09" version="1">MPPKKIRKVGGEADLAPILPNGTNFTNKVIRDTVQITKYIGNGGFGRIYEGKLVGKGTKVCLKVEKKDSSGLFVEQNYFIRFLKKEMLEKWFKKDFISLPYLICFGVDMETFEDELRYLAMPLYEERLSDVINQRVGFQLKLDEVKKVTLCILNALEYLHNVKVSHRDVKKDNIMLVKKGCLDKVVLIDMGISHWHTRFNEKINPKAKHSGTLLYTSIDAHVGREGVFRSDLEILGYNIIEWLKGSLPWKEYEKKPEKVYEMKFEVVNNPKVEINKLLPSIDTSFIQDLFNLSNSLEYCEVPSYDKLKKSLASWKTTASKMSTRSGNPLSNLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2T0</accession>
    <name>A0A0N5C2T0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2T0"/>
    <dbReference type="WBParaSite" id="SPAL_0001229000.1">
        <property type="protein sequence ID" value="SPAL_0001229000.1"/>
        <property type="gene ID" value="SPAL_0001229000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229000.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37549" checksum="8FCE85AC4540066A" modified="2015-12-09" version="1">MIWIKDLIDLLNFIFGVTFTSIALKKSYKILLKNKKNNNGYSHIIMGLSTFGLISSIFQFIFKFHLIIYDGEIIIIIDFFDQLLFNQHTNRFIISFYTFLCYSNIAFPTAIVFASYTIMCRNIQLSKGKTIAIIFYVILAGIVTCIPVYIMLENELPSYIWVKYVELRNYQTLFVSKSSRAISCKATSPLVHLLFYSYASYFIINIGMIFVLYYKYITYMKQWSLIMSNHTKNMYTDFTRLLSFQAFFPIILILIPIIFLYIGVAFGFYEKVEIYGTKVYQLICSISTINSVLFLVLPTKNRRELLIFFKKHYSRMAIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C325</accession>
    <name>A0A0N5C325_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C325"/>
    <dbReference type="WBParaSite" id="SPAL_0001238000.1">
        <property type="protein sequence ID" value="SPAL_0001238000.1"/>
        <property type="gene ID" value="SPAL_0001238000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF13">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001238000.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35731" checksum="369C8D6BFFE36E77" modified="2015-12-09" version="1">MNILKSSPLGAAISSNPGNHHRNVPRRDYRIEFTNLNTINQNIWDGDDNKYRCICKMVHVTKAALHLAYAQLTIFMMFVCVLAYSYIMQHRGGNNGNGQGSGDQMFNGMYMNHNSNFLFSFSAQMFFVILLIHGIRNEKRSLLIPYIVFIMICVLIGFAQLCTELIGSLSQQSSGSYSPSSFDGKSTRGPLSQPFFAMLIGVLIHAWCLNVVWRCYQYLGDKKLAKSIAEQLSHTQSAFNYPHFGYPVFNYPQPPPYSDVVIGSNGTTSEREPMVPGNREDVHREEEIDNNHSGIVVVHDQQQENDGTNNSNEIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3A8</accession>
    <name>A0A0N5C3A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3A8"/>
    <dbReference type="WBParaSite" id="SPAL_0001246200.1">
        <property type="protein sequence ID" value="SPAL_0001246200.1"/>
        <property type="gene ID" value="SPAL_0001246200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001246200.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38665" checksum="EE414B6752D35F74" modified="2015-12-09" version="1">MSSDCKILKDDEIKLAQYIRDSLRISENITKDLKTCIIKRSNGMCENFNNIDKITSSLKDTKYFTKKLFKAPIHSRYSIKGSRSISKKSKSKKVKTKGSTLNDQELKRAKIRKELPAAIQGDLKVETTCDIEKPSIKNMKCNSKSRTNRNDFCSKDILKHIEMKNKEKNVVESNLLNSNKRKKSLKNKVEKVSERNAGSIEIYNNKRKNELKNTPHVFDPLNSTDTYPIIARSLVTSHSSTTVTSVIPYNHKKDKSKDKENSGKERSYQEVPGTHVGFLIKTFKKNSKCKKDESVFDMVFDLSINLGKNKSMIPLNIIANFSSDRNPIVATNGILFEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5E1</accession>
    <name>A0A0N5C5E1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5E1"/>
    <dbReference type="WBParaSite" id="SPAL_0001317000.1">
        <property type="protein sequence ID" value="SPAL_0001317000.1"/>
        <property type="gene ID" value="SPAL_0001317000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF56">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895384" evidence="5">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001317000.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16511" checksum="8419922E7365ACEE" modified="2015-12-09" version="1">MNIFIIFLYIIIFYRQNGDCFRKQGVAVKGRLLCNGKPAKNEIVKIYDLDRNPGDDDDLLDEKLTNANGEFKLNGYTIELTNIEPELRIYFDCNDADRPCMRMVTVPVPSKFIHSGKAFNWYDIGQLDLHYKIQGETRSCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5X2</accession>
    <name>A0A0N5C5X2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5X2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5X2"/>
    <dbReference type="WBParaSite" id="SPAL_0001334800.1">
        <property type="protein sequence ID" value="SPAL_0001334800.1"/>
        <property type="gene ID" value="SPAL_0001334800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001334800.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17330" checksum="630A2669C11C5576" modified="2015-12-09" version="1">MSQDDMEKLILIHNANNEEAWREILKWEELLHPECATPKLKSFKGNAKKLSPRAQIRSFMGYEKPFDRHDWIVDRCGLTDVHYIIDYYDAGAVDPNTKLFTGLDVRPAMDNLTNIMDRMKVGTMRFQVEWLGMTPKLPEHLKKDGSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C774</accession>
    <name>A0A0N5C774_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C774"/>
    <dbReference type="STRING" id="174720.A0A0N5C774"/>
    <dbReference type="WBParaSite" id="SPAL_0001378800.1">
        <property type="protein sequence ID" value="SPAL_0001378800.1"/>
        <property type="gene ID" value="SPAL_0001378800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001378800.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="33424" checksum="6E23E25483E54655" modified="2015-12-09" version="1">MEGKNSAIIVFGSIVQDLISYAKKFPKGGESVRGSSFIMGSGGKGANQAVAAAKLGSVVKMIGAVGDDVFGEENIKNISKSGVDVEGIVKIKNQSTGTATIFVNEEGENCIVVTLSANYMVNEERADQCENCVKNSGIVMVQNEIDENGNLKILKIAKKYNVKTLYNPAPGLPNINRELLKYTDILVANENETEMLVGKSVTTEDDFMNAVKELIEHVNEAVILTRGKYSTIVGIKNDNSNIEIFTIPTISVKAIDTTGAGDCFCGSFAHAYITKGLSIKDSIIFASKVATISVQRQGTQSSYPLKNEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Q9</accession>
    <name>A0A0N5C7Q9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Baculoviral IAP repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Q9"/>
    <dbReference type="STRING" id="174720.A0A0N5C7Q9"/>
    <dbReference type="WBParaSite" id="SPAL_0001397000.1">
        <property type="protein sequence ID" value="SPAL_0001397000.1"/>
        <property type="gene ID" value="SPAL_0001397000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001397000.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18283" checksum="DDDA2F581304989D" modified="2015-12-09" version="1">MLGRPLSSLANLRSFTDPEVTDLLLTVNRLKTFRGWPFDNANGSKCTSFELAKAGFFMTMVEESAPSAQCVCCLKDLQWEEEDIPLEEHLRKMPHCALAQLISKKKEVDVTVGDVMRILSMREVTIAVLGQLAEDFSMINAGMEYNQNFVDKMFRKLQNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7R9</accession>
    <name>A0A0N5C7R9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7R9"/>
    <dbReference type="WBParaSite" id="SPAL_0001398000.1">
        <property type="protein sequence ID" value="SPAL_0001398000.1"/>
        <property type="gene ID" value="SPAL_0001398000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001398000.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="63970" checksum="1BD2E3945C69D1D4" modified="2015-12-09" version="1">MKSETKESVLQWMLGGEMLRQKKVVFSLEESDFKCKSNKFYEVGVQKLMIDAQVYDTKKGVLIGNFDGKIQCSLDECMTGIVLKTKDNEPNHENPNIQYGYYMVEFTSSYQDIPIVISYLKSTNENFVLWICPYVNWIKKVYNASFVPRINLEKGGPVDPLGKHIWTVIDEKSLTSSRFFICGDIKQEASSTVSIAVSASFDYPKQLDPKNLELTDNRVFKCDGKDIFNSNEDNIIYSHYTYNRDNKGAYSENRYWTNTSKLYAEQFIIVFKKYDVKKFLEEKGGTFQRYDPINYESICKVPNYQATIRLMVGDKILPSETTYIEDSGNMVIYRISNELYKNKETSIKCQIVLDNVVDQKFYDFYSRKFNSSLYKKSILYSTSQETLKEHKIINLGSVAFNEVYKCILDPPYLVSYVNRPDFMIVSENYQVMRQPENNVEVVENAVLVQDSEKSIVLYIVIIVVTGSGILLILPAIIIYISYRKIIVYQPSTTNINSLSHSTSSKSLEDEVTSKKTTKASIEKEKTVEQNDKKPNKKSNKKSKNKKSKKSKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8H7</accession>
    <name>A0A0N5C8H7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8H7"/>
    <dbReference type="WBParaSite" id="SPAL_0001422400.1">
        <property type="protein sequence ID" value="SPAL_0001422400.1"/>
        <property type="gene ID" value="SPAL_0001422400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895534" evidence="3">
        <location>
            <begin position="22"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001422400.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41428" checksum="FB6ABE19C208EF64" modified="2015-12-09" version="1">MIFYSHILTILFLVNIKFCHPQSKKIKLLEVSSVNNSEIQIKYNKRPLSINFTDLSNGKIRIRINDIVEDEGPNETEERLKEVNLKKNNSNETNDKHISSTTITENDDNEEENYYLQYIIIGLVIFIILFALSSYLCWYFYNKYKKKDERNKKFKKAHSNIKTTITSAISSCRTNENEGNISASNSTALTLPISKSKTSCLSSSKSKVPKLESIKISEEKNFDDTSTLVSMKTMPDHKNLSVKSISTFINALAFFALEVADRETKNKTPKNTNLQSTQVTSKMLTEQYLKSSVPNSMAKVKSSPLKSKITQIVNIGTIKVDDTQDSEEEKNSKSDPPENTNSNSFRSSNVGNVSSIHPSDLSTQVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8W1</accession>
    <name>A0A0N5C8W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001434600.1">
        <property type="protein sequence ID" value="SPAL_0001434600.1"/>
        <property type="gene ID" value="SPAL_0001434600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895666" evidence="6">
        <location>
            <begin position="17"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001434600.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44594" checksum="83D7989DF6C719BB" modified="2015-12-09" version="1">MKKVFCIFFLVQLCLAHNGTENDIHVRRKRTMIVDKIPSYPTLPESIKYYVQFIEKNSISMHLQFISNRICLSFSRQKDRVRNKGINFLKSFEKSGIKLPKTNNRSADIYLRSQDLKNTRLVLHYIGLALGLVPEIQRFDRNKYLKILWENLNPIGLEYYKKKGYKTKRYTSFDFGSIMLRSPTYGTIDKKIAFKTNLYPYYDLLINKRDRFSHYDFKLLANAYCKNKCPEHGKCANGGYQTPNCQGCICNRFFTGQHCEKILEHDSKICGSKQYFDASSTKRYLTATNITGPCYFWIKPKKNRNTKITIEKVHFDGKVSCVDDKGLFVYYRRDKGVTPLCLFKDDEKFTLSTLPNHVYIIFNGLGQNNSFTISYQSIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Z8</accession>
    <name>A0A0N5C8Z8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C8Z8"/>
    <dbReference type="WBParaSite" id="SPAL_0001438100.1">
        <property type="protein sequence ID" value="SPAL_0001438100.1"/>
        <property type="gene ID" value="SPAL_0001438100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057284">
        <property type="entry name" value="FF_RHG35_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039006">
        <property type="entry name" value="RhoGAP_pG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23083">
        <property type="entry name" value="FF_RHG35_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51853">
        <property type="entry name" value="PG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG2 pseudoGTPase" evidence="3">
        <location>
            <begin position="825"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001438100.1"/>
        </source>
    </evidence>
    <sequence length="1685" mass="194636" checksum="2ED6BD7197C5C26C" modified="2015-12-09" version="1">MSNLETNIPPTNLSTKWYQNDGENLLNVQQSSIKIQQENVVQGNKKHHLITIAVVGLSGPSYFKGISGVGKSCLCNRFCRQNYDDYIDDHPSILSQADFCGSPVINNDHWLWWGDIPLDPTITDSFKMKTTHIRVIEQTEFLSDETYNSITHKGSNEQKDLNEYLKRSSMIKLESQGKLMYISTDQLGQEDDYPKVELSDGKVSIDAFIVVLDPVYIKDRNLKFTSFFTIELIKLLHKTKKPIFFAATKCDIAEREYLENLQNIFISKDWKLSPIPFVETSAHNNVNVKELFYYIAHQLERNKNKFKLNCYEEGLALQRRREDEVRKNFKSLLESCIPIKNYKQIDNIPWIELFNNLSYNPHSNFTTFLNFFGSSETINFFKEYLEHLKEDWINSSLISHLPSLKTVFSSLLNKSKIEYLMWEDAKNIIMKHPLLLQYFKESSSDIKNQRMENNDKFERAKIPIELLDTIHAQKAFTNYQHELEIDRREKQREFEFIQFLKECKQITPGKTFNDAVIFLKGYLPYEQLSDNKAIKIYEEYQFKLIQMAEKNFQELLLENIEIFYNMFNDKVNRKFYIKKSFKQTWFTEEDYKQISSILVDDIRYRQLNILHDLRKRMIEKYASYIGGECQISNSCPCGFQCTDGIAMEIIDQHLQKVKEINSNIPKNIEITIHGDEAMAEEFMSSIQEVCIRMGYNTPTNKKSAVTFTYTVFSNNYNIKKVEKDISKISVFIVPSKENFEKFIPLIENEIIYSQMPPVIVEPPAMNGKNHRLMSEEDNLSNAVNNFAKKYDIDVISCHNKYDYQLDNFVANTVNRHLSGKPSNLKINLLIMCQDENPINRILEPIYPYLSNNLYSLSSGFLTFDIPIYDSSSNLIKTPSNQQSISNILRVDVKVYSYHSWLNSNNAQSTNNNTNSQGYILTYQANRVASFEHMKITINNLINIDKQQNKQLKKCLTIGSCIMINALAGLEDYFQNKETNRMLTEGNEIAANCGALFQNNLQSCSNEAEKTRLINFFKNIYKLSQEECMSLSTINASDTDSNSSGFASTTINSNGSKTSAFSSNGNIPSSNNFKSPKSSRCPSQQSNFTQYSASSPLQRIKNSPSLDYKGNIPTPNNLIFPTPSNMTVNAPLATPEENSDFNEDLIYIHELYNSIDYQKKSNDTLKPAPFPTALSNISIIENNANNIDDKKKYSSNVQNEFEFQKPEVYEYNINIKYDRCMDDKLRNIHSLSEDNEMENEDPIYEFLDYVALKKEREALNNRNSPTGGSDGIVSRDATIRRKVDFTNIPQYRSFDNLLLLEKKESIENEKKGKRFDWNKFPLLRFMSQSKMTKSSPSTPIQASREKTKSLIDIDNPLDNVIEKFASSFKKGFSKKKFKSNGENEAFDKLNNCDKLNFSVDFDRITLNSKCSSHLTASSTDGFEHEKIQCLINYHSESKDSSATKFFRFGKKDKKNGTKKENSQQKILLKQNTISTKTLIELAMEDPSERIPLFVKKCMNFLEQDDNIKTEGIYRVSGSQSGTQILEKRFRTEKIFETETLDLPVHTVASSLKSFFGNLQEPIIPEYVHTDIIECIKLYLGGVSTRSSNDDDLKLEKFKNNLINIFKKIPPINIHVLRNLAIHLQRVADNNTFNSMNLSNLAKVWWPTLFRPDMESFIQVNQKGPFLENATFWILKLGKEVCIPTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C928</accession>
    <name>A0A0N5C928_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C928"/>
    <dbReference type="WBParaSite" id="SPAL_0001441100.1">
        <property type="protein sequence ID" value="SPAL_0001441100.1"/>
        <property type="gene ID" value="SPAL_0001441100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001441100.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24741" checksum="C695684E8FAB67E3" modified="2015-12-09" version="1">MSKKYLMIFCLFIGIVFLPSIGGLFIYRDSRDFETLIPTPKVNKKDEVIYGDMVNIVLKKTNNDNYDNGSKYCFHGQMDVEGICICNPGWYGNRCNIKKCSEDIYQGKNSLCMYVDVNEFDDIIRIEQYKEIYYYISNIIVFICLCVIVILMIKCFCSCGDKENPDNDRCIDDEDQVICKSCGKSKVCTFCNEKNYQAPPQYGELFENGKSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9B2</accession>
    <name>A0A0N5C9B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9B2"/>
    <dbReference type="WBParaSite" id="SPAL_0001449500.1">
        <property type="protein sequence ID" value="SPAL_0001449500.1"/>
        <property type="gene ID" value="SPAL_0001449500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001449500.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29098" checksum="279C55CC8B5E18D0" modified="2015-12-09" version="1">MFHSCIVKGSFLERNFIYLICKIITISKRWLKIRGKKTLYTKVNSCAKTFAKEAGNKMDDMVNSLKDEIASATNIVTNQNTKIAQSLITIYDEIIQLLLEPLVFHFLVILILFITIFGLFIYFWNRRLYFSKIFMERELSTAIPLQNSSSVLGKGISLSAQQNNSHIVKTANINFDQISPFPSQKTNDKKSNLNLELQVNINKNFNGTVKETSQLDDVTDWGDNLKTSPNKKCKFIGNNVDHVEEKNSATKKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Q7</accession>
    <name>A0A0N5C9Q7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AcidPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Q7"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0001463600.1">
        <property type="protein sequence ID" value="SPAL_0001463600.1"/>
        <property type="gene ID" value="SPAL_0001463600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="109"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001463600.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31077" checksum="A6E18655CF5D454F" modified="2015-12-09" version="1">MVKINVRYQKYIILLGTSIALRILLYVITNFYGPRIVPLPCNTKDINYPFKKGTVPSISLLIVTNVGTIIISLIIELYESNILKMDIKRKGKNPIFQKSMYFFAVFKIFVLYQIGYTIIFCLLRIFKYSIGKLRPNFVSICKPNFTNVSCINEYYNEYECMSPDKNAIDEARLSFFSGHAAYACYFSTFLIAYMFMRSSKSSKGIKFAYITAPLFIIFGICVSISRITDYKHHTLDVIVGLIVGIAVGISVAFSFEKAIRKDKEIFTYKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA23</accession>
    <name>A0A0N5CA23_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA23"/>
    <dbReference type="STRING" id="174720.A0A0N5CA23"/>
    <dbReference type="WBParaSite" id="SPAL_0001474800.1">
        <property type="protein sequence ID" value="SPAL_0001474800.1"/>
        <property type="gene ID" value="SPAL_0001474800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001474800.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7699" checksum="51BEDF0E79F85851" modified="2015-12-09" version="1">MLNPIENAFSKIKNCVRSRLRNNDNEVLSDVIMSEINNITSTDCNGYFRYITKNITNCAAEPPYCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA75</accession>
    <name>A0A0N5CA75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calnexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA75"/>
    <dbReference type="STRING" id="174720.A0A0N5CA75"/>
    <dbReference type="WBParaSite" id="SPAL_0001479900.1">
        <property type="protein sequence ID" value="SPAL_0001479900.1"/>
        <property type="gene ID" value="SPAL_0001479900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
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        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733484" evidence="13">
        <location>
            <begin position="21"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001479900.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="67609" checksum="E6D43B28E781305C" modified="2015-12-09" version="1">MKLNLFIFCFIFALTSPVNCDEERGASFEPGKFLKPNVPDNVYLAEYFTGREQLKNTWIVSKAKKEGVDEDISKFDGLWDIAEPTNVLIQKDYKLVVKSKAKHHAISTKMRKPFTFKEDSLVIQYEVLYEEGQECGGGYLKLLVKGAEKDLSLFNDKTPYSILFGPDKCGTTAKVHFIIRFENPKNKTVSEHANGKALALKDPNTIFDDKKSHLYTLVINKDNTYQILVDNVVQVSGDLLSDMVPPLTPPKEIYDPKDKKPEDWDDRETIIDESATKPDDWDEDQPETIVDTNAVKPSDWLEDENEFISNPEAVKPKDWDDDMDGEWEAPLIKNPRCEGISGCGKWTQPTIPNPNYKGKWKKPRIPNPNFKGVWSPRLIENPNYFVPKPFEDMLPFSAVGIELWTMSKQILFDNLIITNDIEVAKKFAEETFSITKKKEKEFEAATNPQSGFFKQLIDATEDKPYLWVVYALCILLPLIFGGIYLFGRKTNVSPMVYEKEGNEEKIEEVEDDEEEEEENKNDEQLSGSSEEDDKIVTITKDDLEEELQSSETQDGGASQNEESAGEVSEKEVAKESPKDAVRQRKVRARRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAL2</accession>
    <name>A0A0N5CAL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001493300.1">
        <property type="protein sequence ID" value="SPAL_0001493300.1"/>
        <property type="gene ID" value="SPAL_0001493300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001493300.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18964" checksum="3BB4B34E24A44AAF" modified="2015-12-09" version="1">XGISVHTAIRGHHNGNSICERMIGSVILVHSTIRGHLSWNSICEKKIGSVNLCMRRMSDEYFHRYEKFLLQIMYSLNNTKHIATNTSPHEFMFGWSSLIPADLKRYHNQALNKIVNYNQDKHFRMLAFEMAQKVSTNIKAGQTKDKLAKKVRDKINVNDKEPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAT1</accession>
    <name>A0A0N5CAT1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carnitine O-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAT1"/>
    <dbReference type="STRING" id="174720.A0A0N5CAT1"/>
    <dbReference type="WBParaSite" id="SPAL_0001500000.1">
        <property type="protein sequence ID" value="SPAL_0001500000.1"/>
        <property type="gene ID" value="SPAL_0001500000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000042">
        <property type="entry name" value="Carnitine Palmitoyl Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="19">
        <location>
            <begin position="176"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001500000.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="89225" checksum="75A18BCACBA8A15D" modified="2015-12-09" version="1">MAEARSVAGINIALTHDGVAVSYDQELLRDIWSAFSRSYRKRIARFKNHFIAGIFPANTSSLAAILGVVVLFSFVSIDATFGIVTLLRNWVLYFMFGSGFFCNILSLLIGGLLFWFLLIQLIRLSLKLLLSYKGWMYQSGFEKNVTKFTKIWFSVLHFISKFEPTLHSFQGALPHLPLPTLDETLDRHLKSIRPFTNDEEYDEMVMLTEKFRKGLGRRLQRYLVIKSWLSVNYVSDWWEEFVYMRQRSPIMINSNYYGFDTINMTLTNNQAARAANITWAALTFRRLIERQEVTPFSLSPKAKVPFCTIQYERLFNSCRIPGIESDTFRVYDDAKHIAVYFRGCWFKLPIHSGKRLLDPKELQHGFQEIIDSDCIPQKGEAELAAFTAGERTPWAIARRRYFNTGVNRSSLRAIERAAFVVVLDDEEVFYDENDSSKLDRWASLLLHGKGTDRWFDKSFNFIIFKNGKIGINTEHSWGDAAVTAHFVEYCLLKDLVHQKYDENGNCKGVHEINVHPQRLRWDFTTSCLDDMKVSLNVAKKLIEDVEMALLVWTDFGKGLIKQLKISPDAFLQLTLQMTYFRNQGKFALTYEASMTRLYREGRTETVRSCTSESCDFVRAMLNDNVDNQERLELLYIAAKKHQELYRNAMCGRGVDRHLFALYVIKRYLEEESPFFDKIFPPTYLLSTSQTPLNQCEEDAVGLSTEERSRFINAGGGFGPVADRGYGVSYIINGEDQLFFHISSKKSADNTSSYKFRDDLVQSLNDMKSLLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB08</accession>
    <name>A0A0N5CB08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB08"/>
    <dbReference type="WBParaSite" id="SPAL_0001507400.1">
        <property type="protein sequence ID" value="SPAL_0001507400.1"/>
        <property type="gene ID" value="SPAL_0001507400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="298"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001507400.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51725" checksum="23BC6B87120035CC" modified="2015-12-09" version="1">MYQFERYDPKVPRMVTSFKGNQKLIFEGYRYNIHHLIPAKNAKTWRCVCAKKLTSDRSWCKGRAESYDNDTRGVGKGDHNHEPEHGAAELEYFKSQLIMAAIECPDTPLNELIAEAKRYMNEGLDFPSKDSLKKSLTMARKSSENGGFKFRNYKTSGGTGVKSTKKKESTNESSNNFPALLDSIMSNTPKREADSTINALLSLSKSEESKTIENNNTIQSLFPEKPINDSVNNALLAQLATFHSLQNNNSSLIDNINLLKQFQMTALAAAVTGTPVKSTPPVKRPRKVPTTSSTGNVSSSKAKTSTPKSSRSSTSTNPSMAPSLLSSPSSSINVEQQQQSSSIVPPSSSSSIESGNSMQQKKDSMDMAIRANRLTDIFNRISERALAKATSPTNTQSSGTSTNGEEEKLEAVVTRTIGTQTENDDQSLDEESLIENNKCIAKKDCDCRTIKVCCCSTKGCVRKRKSEEISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBR6</accession>
    <name>A0A0N5CBR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General transcription factor 3C polypeptide 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBR6"/>
    <dbReference type="STRING" id="174720.A0A0N5CBR6"/>
    <dbReference type="WBParaSite" id="SPAL_0001533000.1">
        <property type="protein sequence ID" value="SPAL_0001533000.1"/>
        <property type="gene ID" value="SPAL_0001533000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="6">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="5">
        <location>
            <begin position="157"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001533000.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="50069" checksum="B262D5770D406038" modified="2015-12-09" version="1">MDVPSSSVTNVGLKKHLLIEVPGIVRNINNAIKMFGGIEKLKNCYLHEQQLTFLPEPDNPLEKGTVGERKDLQTMENLYLVIKLRRHKKTHEYKLEILGEASVSYSFKMMTDFMVAPIESAKNNKDIPKDIVNKLFPESLKDSYNWMENINSTGEIFLPPFTFSRYGLPSQRMLCRELEEDEYLKFVSKKGHGTNLRAERKAMSLCVQGDDAFPVAPTDVAVEEANMRCKNQEILDKFEQIFDERPLWTRGAIMIKTGFDEKTLKFILPKYAFYIINGPFSRLWCKFGYDPRKDKESYRYQTFMLTLRRFVTIPQKMQPKSNVLERFSRVDTSNFEEESPEHFYREGILPKSRQIWYSFCDILLPSVQENLNNIKLHPFAKYDKQYGWIPSSFIAFTRKEVRKDIAKIVSTMEAEDIQVIDDEDWNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBT9</accession>
    <name>A0A0N5CBT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBT9"/>
    <dbReference type="STRING" id="174720.A0A0N5CBT9"/>
    <dbReference type="WBParaSite" id="SPAL_0001535300.1">
        <property type="protein sequence ID" value="SPAL_0001535300.1"/>
        <property type="gene ID" value="SPAL_0001535300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001535300.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41847" checksum="EA65C538F4B032F4" modified="2015-12-09" version="1">MNRKRKRIDISNDDLCDIHGEITKFTYTCSIDNFSQRPEKTGESIKFPIYVSGAKDKSEWCLHIYPNGKDEESEGHVSVFLKFLNPDKAKAKLMFSILNYKQEKGNVSDAVSHDFDNERNSTRGCSKFVNRDFLFSKWSGLLVNDRLTILCETEIIELGPEKHDNSETSINITIPESKLSLDYADMFGSPFFTDCSIKAEDTEIKVHKVILCARSSVFSDIFKNTLEKLQTNVIEIEGFSVEVVREMLKYIYKDEVSNIQSMAADVLAIADKFKLDRLKVIASKYLCGDLTIENACERFILSEKFSSQELKEFCQTFIIDNAEHLTTTKEWEELVKNHPFLVESLFLKLLNIPRNSNNSPAEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDS2</accession>
    <name>A0A0N5CDS2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDS2"/>
    <dbReference type="STRING" id="174720.A0A0N5CDS2"/>
    <dbReference type="WBParaSite" id="SPAL_0001601600.1">
        <property type="protein sequence ID" value="SPAL_0001601600.1"/>
        <property type="gene ID" value="SPAL_0001601600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001601600.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36729" checksum="E166DDB12871439A" modified="2015-12-09" version="1">MSGDNNEDHKESSEKNGEPSGINNKGANETKGKVRNTMLLSFGDEMEEEDEFSTVLKGKGKSAHDLLNDEKLSKETAIDTSKFGGQPGSSTTTTGFRKKKPKKEKVAEKLDDEEEDLHKLVDESKARENEEKLKSLKDEIRKMQKEYKKSLRQQQAEEEEEKSETVKEYYSTKLKFKDKTKNIHKLKDPRREEQTMEMLSQFRNKLHELSIKKVMSEKRCADEVKKEEEKKEEPKPMEEENKEERIQMPNLDWEAEDLPDEEWMVHKFVAPAPDPNVTRAKDANLKDESEDWYDLSDPRNKINVRKRMKLDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEY8</accession>
    <name>A0A0N5CEY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEY8"/>
    <dbReference type="STRING" id="174720.A0A0N5CEY8"/>
    <dbReference type="WBParaSite" id="SPAL_0001642600.1">
        <property type="protein sequence ID" value="SPAL_0001642600.1"/>
        <property type="gene ID" value="SPAL_0001642600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="276"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001642600.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52545" checksum="B5DADF332EFBAB21" modified="2015-12-09" version="1">MNRSGIGHVPDLSFEGEDQYYERERDQGVQDGEDTITNRLHVSATSTEMETLRFVHRWVVKQFPVYQELYSTGDFLESNCFGSSDGSYKFHLKLYPKGRDEDCHSYLSLHLAIRRCPTEVIKFKVNFYVETTEGTRACSLNRNMVTIHRGGVVTASKFYALEEIRDKPHLFLPGEALTICVELLVFKDPTSRRVGIDQLGEAFADDLVDADSISHPMRFDSISYPVNFPTPLSTKLRLIGNQDDAETKLSTTQTNLQDKLDFCNDVGKLFMNGDLTDFTVICNGVSYRVHKAVLSARCTYFATLFSDETNVECKSGEVKFEDFDSGIMKSVLRFIYTGELVEESRLLELLVAADRLQLNSLKRHVEKSLVSEVNQSTVCNLLLHADTYNAERLRKRCINCISRYQSKILQSEDWDEIEKNNPTLASQTLKALVMRNHRTQATVRAAPMENSVIQNKKPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGZ1</accession>
    <name>A0A0N5CGZ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubulin-specific chaperone cofactor E-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGZ1"/>
    <dbReference type="STRING" id="174720.A0A0N5CGZ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001711600.1">
        <property type="protein sequence ID" value="SPAL_0001711600.1"/>
        <property type="gene ID" value="SPAL_0001711600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001711600.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="53164" checksum="CA51C03747053BCD" modified="2015-12-09" version="1">MSSSSSGIISDEDLQYYDECDSDGHLNDESLVFQMEKKYLDDSHDLDFIDMFGMSPCHLAVKQCLELVVLNRTNISCIGDEERFASMVKSVAELDLAWNNIKTWKFIDILLQNMSLLKVLNISYNPLHKVLDNRLEKSFTLNVLILNGINLPLDTLKILLSYFPNLNELHLSDNNFDSLDVDVNYDDIFSSRISIFHLNYCHIKTWSTVLKIMCHFQNVKSFYLSGNDFETINLECNESGLRTEDVLKSLHSFCCTNGKINAWKSIDNLSILPSLANLKFTHHPVLKRHTLTERNFLLIPRITSLTSLNGSTLDSDLRITAERFLIRYYKNKPVEERPEVYFKLIKKHGKLNDLALVDLSPKITANVTLMCEENEYNAKIHINLNRTVHSLMRYSEKVTGISINKMRIFHFNVAVQELGPSELRFPNQQLKLLKIEDGDKFIVQSKLFTSPKKEIKPSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHL0</accession>
    <name>A0A0N5CHL0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="1">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHL0"/>
    <dbReference type="STRING" id="174720.A0A0N5CHL0"/>
    <dbReference type="WBParaSite" id="SPAL_0001732400.1">
        <property type="protein sequence ID" value="SPAL_0001732400.1"/>
        <property type="gene ID" value="SPAL_0001732400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001732400.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44290" checksum="48B82B844ACB87D9" modified="2015-12-09" version="1">MISPANYSAHKIFLPLRIRNIEHLPFNSKVVVVSDISREIEIVGELGFDKLVVKPFYQMVVARCCQFMAFEGTPAFRKYCSDTSERYKDEIEKYTSYLFNDLSYHDTLLEVVKFIGSIIRYRDEVRRYFACTFGNVYPEPSEAPRAKMMSESQSTELFNWFKECFAGQKRLQRYYHAGSEYVYGELNPHAFFQLNSEERTLNENFNFFDCGAGIFNIVAMVAATKISNRSIGIELNPGVGCPGALLLLGFYHVARFGNYYFNATSHILGDFNNSALEPLLYSRPSMIVVNNYVLSASTMDPFFKKLARNQKSTVRFILTKEPSFYRRLPAIKNDDSDKKGDKNSRKTKYDLLTISNFTKKVITHIDRAGSWTDNTVTIYYYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHL8</accession>
    <name>A0A0N5CHL8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CdiA_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHL8"/>
    <dbReference type="STRING" id="174720.A0A0N5CHL8"/>
    <dbReference type="WBParaSite" id="SPAL_0001733200.1">
        <property type="protein sequence ID" value="SPAL_0001733200.1"/>
        <property type="gene ID" value="SPAL_0001733200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001733200.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11927" checksum="DECFDADAF796CD78" modified="2015-12-09" version="1">MVVDGIERNPRIEIYELKTGTNSDTHDQGRRPAHDKLECKRCANGKEIENPPDDANTKFHFSLWHHITKKDISKIPDDVFRNVLSIPEKPIIFTFYQKSHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CID6</accession>
    <name>A0A0N5CID6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CID6"/>
    <dbReference type="STRING" id="174720.A0A0N5CID6"/>
    <dbReference type="WBParaSite" id="SPAL_0001758900.1">
        <property type="protein sequence ID" value="SPAL_0001758900.1"/>
        <property type="gene ID" value="SPAL_0001758900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF13">
        <property type="entry name" value="LD36653P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001758900.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26000" checksum="63EBFCA90A4B6B2B" modified="2015-12-09" version="1">MDNGMETPSIENIELRTRTKGGLSVHIKNNYINNLSRSYGDNIVFMERKIRQGDSINKIALQYNVSVPDIKRYNNIVNDQEIYALKSIRIPVTELKRDFLLKQMDKENYSTSDDFDNYSDERTKLINNESDREPSVEDLFVKTDTLMAQARDALPIDEENIGKYHFVDAKSPNNTSNIWMIIFAVILIFVIVPLLLTVIEEETQVEHSSGNDDDHEMMYHFKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIJ9</accession>
    <name>A0A0N5CIJ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001765400.1">
        <property type="protein sequence ID" value="SPAL_0001765400.1"/>
        <property type="gene ID" value="SPAL_0001765400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001765400.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14797" checksum="88E700BDCF343090" modified="2015-12-09" version="1">MINKSSTKHSGDLYQTKFYLNIFKIAYVIYTLKNTPSRNRDINLVKTYLTIINNSWNLYIQYKITKYLNDCYISSNCLTIHQHLKKLKRFNIRNFLSLFTQYIAKGTLQRDLFFFYTYLNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIM8</accession>
    <name>A0A0N5CIM8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NOB1_Zn_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIM8"/>
    <dbReference type="WBParaSite" id="SPAL_0001768300.1">
        <property type="protein sequence ID" value="SPAL_0001768300.1"/>
        <property type="gene ID" value="SPAL_0001768300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001768300.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16415" checksum="427BF2A9F8AB41C2" modified="2015-12-09" version="1">MIFILNINDVECNYRKKKLCILGCIRYNGKPAEGAIVSVEQSTWFKIPTTLARIICDRCGCFIRYTNKYLFSNYDLHVRVKRQYSERKLLCKMDASFMLSIKTVVKSTNKEIAIDLGRVDLITIPNVRKICQPRRSSKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIT7</accession>
    <name>A0A0N5CIT7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectin lyase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIT7"/>
    <dbReference type="WBParaSite" id="SPAL_0001774200.1">
        <property type="protein sequence ID" value="SPAL_0001774200.1"/>
        <property type="gene ID" value="SPAL_0001774200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001774200.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10538" checksum="AB0E2CAC5AD11384" modified="2015-12-09" version="1">MVQKLISVVQYVIQHKKKTQCEKGEKCVDIPNIDDANVKSCVTKVECIDDVFLKCTGSDIRTRTTTTIANKIIVTAAAIVDKVLSGAYGCEANLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B230</accession>
    <name>A0A0N5B230_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B230"/>
    <dbReference type="WBParaSite" id="SPAL_0000013300.2">
        <property type="protein sequence ID" value="SPAL_0000013300.2"/>
        <property type="gene ID" value="SPAL_0000013300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000013300.2"/>
        </source>
    </evidence>
    <sequence length="283" mass="32191" checksum="43169913A57A5579" modified="2015-12-09" version="1">MALIYASAVNKRIGSSGLSKNSGNNSHSHGTKNNKKKCSLEHHQFTCEDLDDNQINYFINSNKKKRSAEEMIIVCRSKDNGCRRSISVCREHPLGKIGYQKVRECISTSSSSRNCSRGSRDDSKCCRKHSKNRSNKKSTGSSSKKSSYEEQTKTIKDKSNNRKISVPPISSPNYIEDDNSKQFKKTFSLQNNDYKSLCSYKQPVNECLCQRLDTNFVTKLISPSHNEKIIPSVIELNGRRKSLSYDNITAFLENNNEGIGDGSERNEMSAFQKMKNRFKKWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2A1</accession>
    <name>A0A0N5B2A1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2A1"/>
    <dbReference type="WBParaSite" id="SPAL_0000020300.1">
        <property type="protein sequence ID" value="SPAL_0000020300.1"/>
        <property type="gene ID" value="SPAL_0000020300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF4">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="87"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000020300.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38945" checksum="972E433E3D9A1E6D" modified="2015-12-09" version="1">MTLSSSIEDFINNDNQKATLLYVSTALASLVFFRGLLYVTRWLFFRKHFFKKPDNSEPIFIKRDGKDVKYVKCTDNTKSYYFNVPPTKRWKITNEIVSLIHAIISGFWAFGVLIEIYAGDDYRNYENGFYYSGALLCMVSLSYFILDTIDTVASARGFSLVELTAHHVLSTIGVLLPFTTGKYMQLVLMGLVMEVNSIFLHTRILMMYKGANKKSKAFKIVSLTTAITFVIFRLFPSLYMVVLFLHYAISGNGDSSIIALILGGSIVFGLLTSNCIMFARLIRSDFIKNKKSSKKSSKKSGKGDSKKGKKVTISEYSTNSTTKTNTSTTGKTLSTKSKSTDRVNAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2P8</accession>
    <name>A0A0N5B2P8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cwf21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2P8"/>
    <dbReference type="STRING" id="174720.A0A0N5B2P8"/>
    <dbReference type="WBParaSite" id="SPAL_0000035200.1">
        <property type="protein sequence ID" value="SPAL_0000035200.1"/>
        <property type="gene ID" value="SPAL_0000035200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000035200.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29734" checksum="18B71671B0372D44" modified="2015-12-09" version="1">MYNGIGLQTARGSGTSGHIQTNIAGTKFVRKPKDAGLEKTIEKAEYELNRGPNLELLEHERKRQVEIKCLHLEDKLEEEGVPEEEIKKQVSELRSKLLEELKSGSIEVDEDLNIKNTHTRQKVLKESRARMRKALKIDDDFVDGSCLKSMAKKDEKEEEEVDDVIEKAAKEKLDKSSLKKLARDILKAEKDAKREERRSKRDEERKSRRRRSRSSSRERTRKRKHSTSSSSSASSSDSSDSDSDSSSDSSSDSDSSSSSDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3H8</accession>
    <name>A0A0N5B3H8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3H8"/>
    <dbReference type="WBParaSite" id="SPAL_0000063150.1">
        <property type="protein sequence ID" value="SPAL_0000063150.1"/>
        <property type="gene ID" value="SPAL_0000063150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000063150.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11825" checksum="59AB33E1C8FA89DB" modified="2015-12-09" version="1">MRKVCSKFVPKSLSNQQKVNRLLISQELLDRRTTEPNFLIDPEIKKKCSQWHIPDLSRLKKCRISKSKIKLILIVFFERYEIVCEKSVQRGQTINLEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Q5</accession>
    <name>A0A0N5B3Q5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Trimeric intracellular cation channel type B</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Q5"/>
    <dbReference type="STRING" id="174720.A0A0N5B3Q5"/>
    <dbReference type="WBParaSite" id="SPAL_0000070800.1">
        <property type="protein sequence ID" value="SPAL_0000070800.1"/>
        <property type="gene ID" value="SPAL_0000070800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000070800.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32797" checksum="6EA021E840D660D7" modified="2015-12-09" version="1">MGMLSTVGVDQQTLMDISSNMQRLKMYPYFDTAHYLLAIISVREDLGTNGTFFSRKHPLSCWLSSMVVCFAGSFLANFLLGEPVIAPFKRHDDIVLASFIWYLVFYSPFDLVYKLAKVTPIKIILSILKETQRAYKVSHGVTYAAKLYPNAYLVHIAVGTAKGAGAGIIKVFEQLVRGVWMPQQNEILRPSFQTKACVAAAIIFTLNKHSLYVTASYDLIYLAIVAFFVYFKLSSIFLNVHDAFAPFENLFCAVFMGGIWDALTRALAASRERKAANGKVENNSIPPETKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3R3</accession>
    <name>A0A0N5B3R3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMRFamide-like neuropeptides 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3R3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3R3"/>
    <dbReference type="WBParaSite" id="SPAL_0000071600.1">
        <property type="protein sequence ID" value="SPAL_0000071600.1"/>
        <property type="gene ID" value="SPAL_0000071600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF13">
        <property type="entry name" value="FMRF-LIKE PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893848" evidence="7">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000071600.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16217" checksum="3B6E6AD185102657" modified="2015-12-09" version="1">MFKYQSCLATVLFLILSISVTLTFSSPTLERHLPSEVTSDQFSAYEVFCREYSHLQLCKLESTLQQALAELQYIILNDEPNEESENFRSKRKSAFVRFGKRSPSDDMNFEKRKSAFVRFGRSIDDSISGQKRKSSYVRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Y7</accession>
    <name>A0A0N5B3Y7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Y7"/>
    <dbReference type="STRING" id="174720.A0A0N5B3Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0000078900.1">
        <property type="protein sequence ID" value="SPAL_0000078900.1"/>
        <property type="gene ID" value="SPAL_0000078900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893949" evidence="1">
        <location>
            <begin position="25"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000078900.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39767" checksum="D67A01C8AD20D46F" modified="2015-12-09" version="1">MILRYPLKLFSIILFFIQINNTLGIIKKANVTESLEIIKKELKYSGEMTKSFDPSLYGYLKELNILNDNYSNVTLKERENPVFVTSVSDPFIPRVIVLLKSIIKNFPKSKIIVYDLGLKKSNVHKMKKVCNVIYRKFKFENYPNHVSNLKTYAFKALIIAEVLRDYKALWYLDSSLTFTKPNLKNVYTAMESKKSPYILHDNPNHGIIRATVNETFNYLPSNMTKLFEDKVPMYQAGFIYVVRNNELMKKVLKWYVLCSLEEDCISPKYSVRKCIDILKSRYGRNIGRCHRQDQSVINIILWNSYNGTIKEYTSGYNNFYKIKRHQKGKWKSLPFCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B431</accession>
    <name>A0A0N5B431_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="10">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B431"/>
    <dbReference type="STRING" id="174720.A0A0N5B431"/>
    <dbReference type="WBParaSite" id="SPAL_0000083400.1">
        <property type="protein sequence ID" value="SPAL_0000083400.1"/>
        <property type="gene ID" value="SPAL_0000083400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="360"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="735"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000083400.1"/>
        </source>
    </evidence>
    <sequence length="975" mass="108528" checksum="88F8D8134F767CC0" modified="2015-12-09" version="1">GKALTIKDASFAWIKETDPFLKNINLSIEKESLVAIVGRTGSGKSSLLSALLGEMTKEKGSVHINGSIAYVPQQAWIQNLSLKDNILFNKTYDEKLYNKVIDSCSLRQDFEALPNGDLTEIGEKGINLSGGQKQRVNLARAIYADKDIYVIDDALSAVDAHVGKHIFDNVLSTNNGLLKDKTRILVTHSLHLLKYCDYIYVMKDGSVSEEGNYSQLIKNNGELAELLEEFLIEEAKTRGRSVSFGEDAEEVKEVLDHLEGIDPIKKRRIEKELLKTVEEIHTSSENIFDKEETLSQVNDSGEKETSQLLDNSNENKTNNVESLTKGQIIQKEGVETGKVKLSVYVSYFKAIGLFCTFKFIFIYLLSSILGVLSNLWLANWSDNAKKIQSSNNTDETNQRLAIYTFLGLSQAGTVSIASIIMALGMVSASGILHQSMLIRILRSPMSFFDITPIGRILNRFGKDIELLDNRLPGAILSLTYYIIGGSTTIVVPIIITPYISIPLIPVLMGYIFLLDIEGLDAAIPRSFVSFIRTVVSSLEILTVIVLVTPWFGVILIPLVIIYFLVLRFYVNTSRQLKRLESTTRSPIYSHFQESVQGAASIRAYGVVENFVYESNKRVDQNLITYYPSIVANRWLAVRLELVGNLIVLFAALFSVFGREGSGITAGLVGLSVAYALNVTQTLNWAVRMTSELETNIVAVERIKEYAELETEADTKTNPTIIQLPTNWPNEGHIVIKNISLRYRKDLDPVLRGISVEIEPKEKIGIVGRTGAGKSSLTLALFRIVELDEGSIIIDGIDISKIGLDDLRSRITIVPQDPMLFSGTLRDNLDPFHNYNDDNIWRALQLTHLDAFVTALPNQLEHQIAESGTNLSVGQRQLLCLARALLRKSSILLLDEASASVDVETDQLIQRTIQEQFNSCTVLTIAHRLNTIKNSNRILVLEKGSVAEFDTPEKLIANPNGIFRSLMKEANLLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B433</accession>
    <name>A0A0N5B433_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4265 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B433"/>
    <dbReference type="STRING" id="174720.A0A0N5B433"/>
    <dbReference type="WBParaSite" id="SPAL_0000083500.1">
        <property type="protein sequence ID" value="SPAL_0000083500.1"/>
        <property type="gene ID" value="SPAL_0000083500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000083500.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17926" checksum="87A2BC7FA55C66A5" modified="2015-12-09" version="1">MSCQSIPNQFLDKGFVETSATGCDDYLALKGMPWLVRKLVCRTLNKGYFKIIPEEIEGVYKIELGISKNRNSYSFRLNEALEDIGYDMKKHKIVFTFENDKLIERHTHLEGDREGDSDDIFYWYFDSQGILTSECFFEKNGVTKTWIRKLQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B579</accession>
    <name>A0A0N5B579_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B579"/>
    <dbReference type="STRING" id="174720.A0A0N5B579"/>
    <dbReference type="WBParaSite" id="SPAL_0000122600.1">
        <property type="protein sequence ID" value="SPAL_0000122600.1"/>
        <property type="gene ID" value="SPAL_0000122600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000122600.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41948" checksum="1F77B0827AAA99CC" modified="2015-12-09" version="1">MIGMIFLDIFLITQTWSFSDVICIGYLMNEKITIFLAPIVVLFISHTCHAMVCGDIIAQKKAALVKYAFIKVIVALIAIIIILIPIPLYASKRYLEGKKVYLCEFNPPTFIKQFLHYSACFVSFACPLLGILYWYLSVPLFLKKRANTVIVKGHSSTHAIKRIIKTVVILTIVYLIFWSPYWLLLFKGNALFQILKAIHIPIVAFNYIQLTIHLLPYISSLIYPLIFILMNASIRKAHSEVIRHQKKRFKRLPSEIINNFQSTFQFSSNTGGKQTRLHYVTSDDSNDNEQTKMTLDGSNDYKSINFIENVLSEDVETVPGVISLNYYNSNEKKIDDFGDDSKNSCNIMKEYTNDSILIPHQDDCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5S6</accession>
    <name>A0A0N5B5S6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B5S6"/>
    <dbReference type="WBParaSite" id="SPAL_0000142100.1">
        <property type="protein sequence ID" value="SPAL_0000142100.1"/>
        <property type="gene ID" value="SPAL_0000142100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="585"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="791"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="887"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1573"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1669"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1761"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000142100.1"/>
        </source>
    </evidence>
    <sequence length="1873" mass="213637" checksum="FE99B72998CF0BC2" modified="2015-12-09" version="1">NVHKDDSKKAPEVKAKPTEEKPKDEIKKDDSKKAPEVKAKPTEEKPKDEIKKDDSKKALDVKAKPTDEKNLDEVKNDVVDVSMMSKEDKEIPTDRKYNDEVYKDFVDLSDAIIDLNTKPKDDKQKVDSEDIIIEQKLVEKVKKTKSKDSRDVSKKKSKIKDKSSNEKGKTETSNDKEKNLVNNIDVVEYIDIEDKKYNGIINEEDSNYTSELSSDGTADNDVNETIKIKELGVENDKTVNQPESDKSKETNFDFVINDNIVIDDKDLNFINKFDKKLSKEEILEDYNDYEEVEIKIKKRQPRRGFALRPSSKIYGKRGDTITLECELYHEDDIVSWKYNNSCISDFRMTIKDMPYFSKLIFKDVLPSDSNSIVEYTTNDGENDISYQSCLQIDEIPIDFVKYLERKYNGEENGSIEISVELTYATDNFNWFINKHKIIESEKYKLSVINNIYILHIGNLKYDDCGLIEFVVNNGPSCCGNLEIYGKPIIIDKMNNERNITGDIDDSITHTWNIQSHPEPDCEVYFNDNIIDLGIRFNVEVFDNKILLTKRNASRKDNGEYKLRVFNKYGEDYDIFHIFINDVPLPPSSLYLNSIENESIIISWSLPENSDESTILGYVIEIKEADRRVFKKVGQTSGNDLEYIIENLDINTEYLIRVAAKNKYGISEFTEPIMARTNSPYKAPIITSSPIIKNIINNSCELEWEECTDNGGSEIYCYDVFGNENDKEWFKINSSPIFTCNFIVRGLKYSDDENLINYKFKIEATNGAGMTSKCDLVSETITMSKKISKPKKITNVPVVTIVSCDSVTVDWICSESPEDCPSYIVYYKNEDSGTDTWKSIKATSPPVLINELKEGISYIFKVCGENNEGEGECSEICKSVRMLANESPLFTKMLRNVSIAKKSSLQLECHAIGEPSPSYIWYHNNDEIIPSETNDYEILIEGFSTTLKVDRIKEKHSGEYKCIAINEHGEDETKCKLSVVEVRAHFVSTFPEFITIEEGSTFELVCELSDDDACVTWFKNGKRINESAIAKYDIIVDGPFRILRVKEATIFDSCDYTCVTSEGRRAMGEVEVFEKPPYIEIGPQDYTVTSFGETVKLSCITSAPARVVKWYKNGKEVWPQSGKIFMNKEDCLCYLDIYDFNERDIGEYNVVIGSDCDDISAPAHINMLVQPEIKIISYNGDSEIHVGKDLFIQVEINGVPKPKLLVTLNNENIKLLGGKIEEYENEATIRLTHLERMHNGILKLIAENDVGIEEKGSIINVIDIPSPPTNLRISDIRSTKVKLTWEYPKDDGGCQIDYLLVERKTAEHTRWRVIHRLKSFKEQYLVEDLYPDVIYAFRIVAVNDVGRSDSSNVVDCITLDDDSEDVSLIETFIVDQFLQPPNRPNIVTNGFFAEVLWDEIILADEYVVERKEEDDQLWIELCVTDKCHYQDRSCRSTGRYFYRISSKSGNKRSLPGEETEFVFLLPVKVSEKDDSSDNQISENTDNMENEQGVIINDTINKNENNDIDISQIESKDDTKLLKEEPKINIESTNEEPKTDVVKKKKVVKKLKKKKEVVEEGKSLVKEEEIKEVAPVDTEKLEVFENETSIVVESGCNTKLISYLKSGTPIDSKWYKNDQEKTPDCYVTFDKESIYSIKKASEIDCGVYKCVWYDSSTTIEQTFNVSIKGVPTLDICNSTVEIKSGTSGKLYANYNGCPEPKISWFFNDKEIGPNNLIKIVTKTGESTLLINDALEEYAGIYTVNATNEHGSVDKQIQLNIYGPPSSPTGPLVVTKRDENSVTLSWNQPTSDGGSTILGYCVEKKETTKSSWIFVDRTTQTNFTIKELKNNVKYDYRVSAENKFGTGSYLESSTNIIDNNEKESSNDKKKLKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6V1</accession>
    <name>A0A0N5B6V1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6V1"/>
    <dbReference type="STRING" id="174720.A0A0N5B6V1"/>
    <dbReference type="WBParaSite" id="SPAL_0000178700.1">
        <property type="protein sequence ID" value="SPAL_0000178700.1"/>
        <property type="gene ID" value="SPAL_0000178700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="59"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="257"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000178700.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45645" checksum="86EC033997E322BA" modified="2015-12-09" version="1">MSRKRNAPVEEDLADIEFETSDNIKIFPTFDSLKLDEDLLRGIYSYGYEKPSAIQQRAIYPIMKGRDVIAQAQSGTGKTATFSIGVLSRIQVKTRECQALILSPTRELAVQIQKTVLALGDYMNVQCHACIGGTNVGEDIRKLDHGCHVVSGTPGRVFDMIRRRNLRTKNINMLVLDEADEMLTRGFKTQIYDIYRFLPPDVQVVVVSATLPHEVLEITTKFMSDPVRILVKRDEITLEGIRQFFVAVEAEEWKFDTLCDLYDTVSVTQAVIFCNTRKKVDWLANKLKDNNFTVSSLHGDMTQAERDEVMREFRGGKSRILISTDVWARGIDVPQVTLVINYDLPNNRELYIHRIGRSGRFGRKGVAVNFVLKENVSILKDIEQYYATHIDEMPLNIGDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6V9</accession>
    <name>A0A0N5B6V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6V9"/>
    <dbReference type="WBParaSite" id="SPAL_0000179500.1">
        <property type="protein sequence ID" value="SPAL_0000179500.1"/>
        <property type="gene ID" value="SPAL_0000179500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893976" evidence="2">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000179500.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="59489" checksum="94BD8B3DB6EA9EF8" modified="2015-12-09" version="1">MNVFILTFYSCVLFSVSFGGTGDIFGDLWGDTKETFFNLFNKHPASRSLYEFLDLDINPCDNFYQFSCGKWIKTREKKWGNSGSFKYNHRTGNFDKFVNGNIFFVFIYLLSEVVNESKYKDESRIFSTFKNLRNKCSQELPKDKVNNCLSEILEFGKYALSSVFLRRNMRRIEKNGGYEKVQNMYKFINEQFRLLIDEKSEMFDLNTRKYFLQKIDSLKLVTSLDDYQLSNVKEMEDCYYRSIEIYYKDHITTILASINNLKALSRNDDLTTCRGKIFQIDKFMYKFVYGNGMYVPYLNVFAINSDLVNEPSFSSDFPYSLNFGYLGNIMAHEMLHGFDSNNYNRTMANKISDYKVSQISVDNYEKKASCFVEQYNKQKENITNRYIDGSKTLGENIADNGGLKVAHRAYLKFREVFNLKNVPVEGFEQFNDEQLFFISVGRNFCKYMSKDILEKEIIRDSHTPPEIRTNVLLSNYKPFSDAFNCPLNSKMNPEHKCELWKIKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B760</accession>
    <name>A0A0N5B760_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule-associated protein futsch</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B760"/>
    <dbReference type="WBParaSite" id="SPAL_0000188800.1">
        <property type="protein sequence ID" value="SPAL_0000188800.1"/>
        <property type="gene ID" value="SPAL_0000188800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000188800.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30456" checksum="00637045DEA2669B" modified="2015-12-09" version="1">XKKKIKKDQKNKKVEKPGDKETSEICDDSTIISPVKISLNEFECNDIESTLEISFDGSDIDKDEKVFLSDEQLNDGIKKKKRSTPKKLKIPKEINSLYGEPSKKISTLNVTAEIEPDAILTDDEAHITLSPIEPLSTSISIKSPKISKDNNNKIFDIDDQEDINEDDNTYNDIEKINIDEIKKDDSKKAPEVKAKPTEEKPKDEIKKDDSKKAPEVKAKPTEEKPKDEIKKDDSKKALDVKAKPTEEKPKDEIKKDAVDASKKALDVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B769</accession>
    <name>A0A0N5B769_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B769"/>
    <dbReference type="WBParaSite" id="SPAL_0000189600.1">
        <property type="protein sequence ID" value="SPAL_0000189600.1"/>
        <property type="gene ID" value="SPAL_0000189600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF93">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000189600.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58626" checksum="73403370240FF0E7" modified="2015-12-09" version="1">MVLDSSVLGPIKIIPARAYKKAQQQYLQHAYTNKIDQSEKNLENKVNEEFDSKKTIQENEKNNFSDFKNKNPTDIPINIKYYMSNIYENGYNSQYQQQNIPQSRGLYGQNGYLENHYGTAYFNQAYSHDYNGRYSYNPDYALSNPYRPYPQQSPVTGGGNLENGTLLHSYRRSRTAPVRTLPRQTQNYNTSYNPYPTTQRNSGTHLRGHSADPPLQTNYKYISNYVPAYTTTSQNQPKKRLSNTMTNAQYNQRIKSTSGIKYSQEPIDYYQQKTPSTNIFNYNTAGPVSPSAVSAVPYNTISPNNPTLRRVTPYYTNYQTTHTATMYPGSYSGPQMYQAQQQYPASVYGGGMYDRKRDPKAVSKKYPLFARITIKIFELILGAAILGLVIGPSTGYSFHDFVIMTRTEWQGAVVGIVSVFAICTLCLLLTICLANKQYFWRQFDVAISGFAILLYLVTSFLEAYFAACYPPYGKQIDIVCHRAEWIIADILCFINLVIYIIDFVLALRTGVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7B4</accession>
    <name>A0A0N5B7B4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Secreted frizzled-related protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7B4"/>
    <dbReference type="STRING" id="174720.A0A0N5B7B4"/>
    <dbReference type="WBParaSite" id="SPAL_0000194000.1">
        <property type="protein sequence ID" value="SPAL_0000194000.1"/>
        <property type="gene ID" value="SPAL_0000194000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF148">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894066" evidence="10">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="36"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="177"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000194000.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36975" checksum="4CD6532C07FEB0A8" modified="2015-12-09" version="1">MLKKLHFFIFLNFYIIINGNYISSESSWSSFHADRLTAPKCVDIPSNFTLCKNMQYSQMRFPNFFEHETLAEVLEQSESFVPLANIDCHPDTKMFLCSLFAPVCLSSLDKHIPPCRSLCLAVRQGCESRMKKYGFDWPEMLNCNNYPIDNDMCIKALTPTKPSTVIFKTTPKPSSQCRSCGQISTFENIIDNYCRANIVIKGKLNKVDRNHVTINNGGIRNLKHDDGKRHIPKNKLIRLNDQNENGRCTCKIEKGNHLIMASQLQDGTFVAKLIMPWKRDDPEFKKTIRSIKKINCQSLGREIRQSVFKRPHTRQHFSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7N8</accession>
    <name>A0A0N5B7N8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Vesicle-trafficking protein SEC22b</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7N8"/>
    <dbReference type="STRING" id="174720.A0A0N5B7N8"/>
    <dbReference type="WBParaSite" id="SPAL_0000206200.1">
        <property type="protein sequence ID" value="SPAL_0000206200.1"/>
        <property type="gene ID" value="SPAL_0000206200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893891" evidence="16">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000206200.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24960" checksum="A8EAE28044888C42" modified="2015-12-09" version="1">MVLLTLIARLKDGLILATSIEGADDRDNSFVKYTSQAKLLFRRLGSESGPNERSVTSDPYVFHYIIRENIATLCLCEQTFPRNSAFAYLEDVANKFIEQYGTTRIDQVLRPYHFVEFDTYIQQAKRKYADKNRFAMSAVSNELQDVQRIMFSNIEDMLHRSEALNILETRADGLYEMSKKYRDDAKLLNQKSAIFKIFVGMGVAGFLFFILKFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S9</accession>
    <name>A0A0N5B7S9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7S9"/>
    <dbReference type="STRING" id="174720.A0A0N5B7S9"/>
    <dbReference type="WBParaSite" id="SPAL_0000210400.1">
        <property type="protein sequence ID" value="SPAL_0000210400.1"/>
        <property type="gene ID" value="SPAL_0000210400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="101"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000210400.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="61664" checksum="EB6AB6A102516F04" modified="2015-12-09" version="1">MPTMEKLEKDVNVQENVLDGKDVELLETEEDEPTEDEKLKLFQQFHDDLGHGSIERIYHVIKIRKNWKALRKDLKLYLSRCQICLKRNQTYKTCDVEKSVYASRPWEVVNIDVLGPLQVDEYGMKHIVGIIDLNTKYLILESVPDCTTSEILGALERSLFFKYGAPERIRTDNAPYLKADVMKTITKEYGSVMDYGTPYLHTSSTHIERAFRTIENQLAKEANGSYTGWSKLVPQVAFHYNCMTHGTIKESPFKMMHGFNPLFKYDFERNKDKILNVFDQDTGLYAREKSFQLARLTAEAIHEEARGEPVEPRDDILFEIGTSVIIKDQLAKDKFAMKYTPGYRETKYDFERNKDKILNVFDQDTGPYAREKSFQLAKLTAEAIHEEARGEPVEPRDDMLFEIGTPVLIKDQLAKDKFAMKYTPGYVITGCKGNSFFVKKAHLRGRPKDEPVEPRDDMLFEIETPVLIKDQLAKDKFAMKYTPGYVISGCKGNSFFVKKAHLRGRPKLVHRDHIKVNTSIHKEDEKVKIGGVNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9B5</accession>
    <name>A0A0N5B9B5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9B5"/>
    <dbReference type="WBParaSite" id="SPAL_0000263100.1">
        <property type="protein sequence ID" value="SPAL_0000263100.1"/>
        <property type="gene ID" value="SPAL_0000263100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF26">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="58"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000263100.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="51025" checksum="81CF4AAC13823F6D" modified="2015-12-09" version="1">MEYYLEDELAYSDYNNLTSGELQEIYRRLHPTVPVFIKNLSQVDIGIIHLTLSVSFFIFQLLIFTSFYNKKELFKNTCFYVIFHHGLLSCIQQICHIITAILTILRMENIETLFMIIGALLTSTYIGSVLFILLLTINRFAIIYNITISHEEQKRKFYFIVIFILYTWVIGLFVFYIHPQFNVTFDFEEYQWQYVNSEDGDIGFQMENKTILTSLGISFILQMCIIFKIFSLRFYAKKRVIFVAEDFKIVIHAFLCFVTTLFLELIWDGVFFEFDVHGIEVIVPQILYIFSSVSNSIFVLFFVREIRENTIFFKSCRKNKNIKFKSIVKLLRMMSSTKSLSNLNNREYSLYQDKDLYLDLLNLRLTESKVTFDKGEQMTPLMLNAFCRAPVRPILRRSRIKPQNEFMRSRCLFQSSNIMPAVSGDAENVQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9P2</accession>
    <name>A0A0N5B9P2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9P2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9P2"/>
    <dbReference type="WBParaSite" id="SPAL_0000275800.1">
        <property type="protein sequence ID" value="SPAL_0000275800.1"/>
        <property type="gene ID" value="SPAL_0000275800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF6">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="101"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="387"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="559"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="698"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000275800.1"/>
        </source>
    </evidence>
    <sequence length="1013" mass="114454" checksum="DE84785B4A9F9645" modified="2015-12-09" version="1">MVTEYQARTLENVVDARIGILQFEKEEDDEMEEDCSFCRSLDCDILFALSFTLIIIGLLILIVIFWLKECDYLFDSTKPKGTFNFPILTTNPSLYNNKHSSNGEVFSTSLTDELNTNSDLIESQIADNIQCIYTFVARKGQRVKLEFTDFQLAGTVDNCEVEYVDIYSELKDPNEDLLSVEVGGRYCGTVAPTIRISLYNIIVLVFHSRVGKKRNENLVIKGKYSFISDEKYIAGLPLPKISMCSFLIEHNGRKSKGVILSPTYPGVYPNNIICVYLLKGKPNERIRIFLKDFDIYFGGEHCPYDVLTIYDGNDNTSPIIKKVCGLQQKMEIFSSSNNLYIEFLTSDPFKNDQRGFLIEYEFSSRFVHIPKLIQSSKGVTHIRGTECDVRVQSSKESTHYIYSPNFPDMYPSNISCTYILDGLQGDQNLEKVLLTFEQLAVFSENYNNVGVINNGINNNDIECPSAYVGIAYDINNIKAVLSNSEGSAFDKILCERLVSGNELMGPYESKSSRMVVDFESADNPRNDGNVNLGYGFKARVDFRTDFGVPGEAVGDSNKCLFRFKDKKGSFNSPRFPSNYPLDTTCTYLIEGNPGDQIIINFDAFKLFEDLSTDICNDYIELYNVFTDKRGQETFQLQEKYCWNMKPGPSISAYNAYKMKLIFVSSHEGSSNGFKATYKIKKRFKEEIPSVEGKDDDHCGVSIVASDGFTSGTFKSPNYGTKYAKNTYCDWEIVAREDHQIHLKIGKLDVEGTLDSDRFSCLSAVIRVLPDVTDPTSVIQVCGDVATNVKPVTSKGNKLRISFYTSMDKVNGLKGFLYEWTEVKIVEKDSECSGDDKYLCTYSKMCIDKELRCNSMYNCGLNDESDETHCNITELASDLRSVIAAGIFSGAILLFILVFFAFLFKKKMEKRRIKNSIRSSNFRGAKPRIPYRQQQPVGRIIVSNKDLDLSRYEHGQNGLISSPLTSRFINHDATGIVPPTSTTTTDSIKNLDESCNVNRNMLLTTRLDDKTFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAP2</accession>
    <name>A0A0N5BAP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CCR4-NOT transcription complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CNOT1 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BAP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000310900.1">
        <property type="protein sequence ID" value="SPAL_0000310900.1"/>
        <property type="gene ID" value="SPAL_0000310900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="239"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="511"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="713"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1667"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2042"/>
            <end position="2066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000310900.1"/>
        </source>
    </evidence>
    <sequence length="2066" mass="234378" checksum="7F10682B10266879" modified="2015-12-09" version="1">MSLTVFNLDNPSNWKITSSIHECREYLLAQENGENNVTEENVSQAIIAILKILSGIASEPDFASLESTINGENLAKAIIEIKPQLDWRRVIELLDDKELKVTSPRGLMVITSILRTAYPDPATFPIDCLYRIWNNKKNHLSWISTIVSNSEIFSFEDYKHIPINTSAMKTQPPDTKDLGNWKCQEFYELIFHYIDISDFTRAIYQIFQRAACQACNSELLVLGMVQSIPPREFTQTRRNLMKALIQTLIMSNSPSPAVVNVVWNWPGWEFTTDTPKLVIKQVFADIYTNCPDEQKLTRTLEIAHELKPDGLTDILESGNNREFTLNLAFLAARRDYLKLDTYLETMIDKALENPENNFIFELVRVVKKKLALPPGSNSVVFSRDTITIIYNVLAAKLSKDRTNTIKNCLRELYQAIKDRDVPKENGATPIVSAPPNEIFNRGVANRPVYPPILPLPGNINQQSLMMRNMINIRQGVIGQSISSGQSGAVPDGIKKEPIMEITGNEDLSIYKFEQHAQDKANILFQTIYSPSGASGVREFIDKLKICKNSAKSEDKEVLLCVIKSLFEEYQYFKDYPIRELRVTAEVYGLLIKENIVTGQHLTYALNRIYESVKDKDSPLYTFGLSAIAVFIEKLPQFVPFCRALTTYSHFKMWPTDLRTLILNITNGVPIERLGIPPLKTQNEVSAGKQSAVITSLANVDTLVKATEGENSQCKNPPKDVIEKVGFIMNNLAENNLKEKALDIKEFIKSYKEDFSFWFARYLVVHRIAIEVNHHKMYNMLLQEIGNEILDDMIKKETFRSITILLRLDTRVRNQAYADRQTLKNMGNWLGMITIARDKPIVSCDLDLKSLLLEAYVKGEEEIAFVIPFITRVISSAAKSTLFDAKCAWISSILSVLAEMYYESSLKLNLKFEIEVLCNDLEIKLSDIIVGKTLKNTDLIKGLTSQMGKFKKVENETAPSPIPQTLRQPIPPTNSAISLATAFTANEEVAPPIESLYKFHYHDVTVNVVDFFTKNCAFPQGNLIIQAMPIIKRTIFKAMSDAIVEMKPFIFEKALKHSLAVTESLLKKDFIFETNVYKIKEAAHNLMRSSTAALIAVNVKDHMAQTLMHQLKTQITNVVMQQSDLNIPKEQLIGLIDALVKDLYALNEELVTCISIKNAVDKGAVDITRIVSEYVNGRFMIGDNKLSPAPNARAIQSVLPDELKFNEDGVTYTQYKVYENLANTICGFRYTASNPVDDFKVDNLPMPQNIFEPESMSKSILIMLRCLNGIIQYHQANSQAFPHVKAFQGLGGIRNDLSTLLSSPKNPANLIAAAKGMVEHFMGGYELDFYAKNKENKQLYVFGIDTNTKLRDLFLNFIQQLTAHVRSHEIVNIITKTICERSPELLIKEIPAIEIMCRSGLINPKAMDYYFAKKISEKSIPDINFCSRMNAYFSMDVKFYHHFSSGFMTTVIALKKYNASLAASRETPTVPISNVSESIENVMFNGQDLAQFGLPVDKLHQIESTLNISATSTFGESPSPIALKGEKVYREWLKHVHLPEYSSRSVDLYKIIFRLMDDEGVLASDEILTEFLFCIIHMCVDLSKRLDEVFTGVMNPTVLRQRHHRHLDGFVKLIYLFVKFGDTSSPTIRSKIFISFCAIFTRSFVGEYNANEAKFLPHIYHRMMLMLFCQLTRPDSELEPISLQICETFGQLMFTLQPRNYPSFVFVWMDILAHRNVMGAYLDNDGKSPESIKKWSVYAQLLSCGVKFLSPFLGKNTEMKTSIQHLYSGLLKILLVLLHDFPDLLSEYYFKLVDYVPIHCTQVRNIILSAYPKSQPLPDPFTTNLAHFESLPEMRADPKFHLQFNNYLPSAFIKQLDDFLESRTNVDFLSQLTTLCKSHPPNSNPESKYNISFINALVLYVGVKAIENLHSKNLPIVTATVTHSSYMDVLEYLAASLDPEGRYIFFSAMANNLRHPCSHTLYFSKVLLYLFKEIGQIVIQEQLTRTLFERIICLRPHPWGLLVTFIELIRNPTYNFWSHSFVACAPELNRLLSCVSNSAQVKGSNLDLSSTTGTSSGENTSSAVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBV7</accession>
    <name>A0A0N5BBV7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticular protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBV7"/>
    <dbReference type="STRING" id="174720.A0A0N5BBV7"/>
    <dbReference type="WBParaSite" id="SPAL_0000350800.1">
        <property type="protein sequence ID" value="SPAL_0000350800.1"/>
        <property type="gene ID" value="SPAL_0000350800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894266" evidence="2">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000350800.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31891" checksum="9FBDDD2F68D388D3" modified="2015-12-09" version="1">MVSLSLVLPLLFASSTQGFLWGCCNYSPAAYYVQPSGYYQPSVSYAYQPPTTYYMKVPIYAKISNLPSYPTPYAQPSTYAQPGGSYPSSYGGASSSYSSVDMSHLYVQPGVDPNQLTNVVIYDRPTNNYVTAPRVQQTYQPPQQTYQAPQQGIAQPPQDSYDPFPRYENKAVIKTETSNYSPVESTQQEEIYKIKSEQTGPYQPAVATEAPYQPAVVTEAPYRPAVVTEAPYQPAVVTEAPYRPAVVTEAPYRPAVVTEAPYQPAVAPAASYTPSSSVNNAPGTNEPYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC00</accession>
    <name>A0A0N5BC00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC00"/>
    <dbReference type="WBParaSite" id="SPAL_0000355000.1">
        <property type="protein sequence ID" value="SPAL_0000355000.1"/>
        <property type="gene ID" value="SPAL_0000355000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894044" evidence="1">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000355000.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38461" checksum="DEB8C1F077D0BDFE" modified="2015-12-09" version="1">MIFKILVLLSLLSVSFFLPQEDSDIFFNCHNSPEYDTFDLIIPSFCATNRTYSWYLEFKKPIYLHRNNQSCTTSLKILFVSKKYVMMPIKNNEKDDKVLLLDYLDSYHLDHPECVPEHKNYYRFNYDIYIDVEKNHYWNRHNGTNKNAIENSFLEMIDIIHKGELNREALILGIQSYLLEKSYSRSPSLFENDFIKDKSTGIFKWLKLKIPKKKKFDFTNVYRNFYRLTKLQLSNNENDLKIASKIIENKTNELGNIYYYELCHARNEKLKHFTDGTTPDEKVRKYLGRNDIIAKEIESKRYYMDYQWDGGATTSLPTEDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC88</accession>
    <name>A0A0N5BC88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000363500.1">
        <property type="protein sequence ID" value="SPAL_0000363500.1"/>
        <property type="gene ID" value="SPAL_0000363500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000363500.1"/>
        </source>
    </evidence>
    <sequence length="13" mass="1505" checksum="0F8EFD9992EF245B" modified="2015-12-09" version="1">XGVGFYNLQINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDK8</accession>
    <name>A0A0N5BDK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000409100.1">
        <property type="protein sequence ID" value="SPAL_0000409100.1"/>
        <property type="gene ID" value="SPAL_0000409100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000409100.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7686" checksum="5AEBEA6071DAE135" modified="2015-12-09" version="1">XKIAVSDDLREIAGDVDNISDSLNAIFRYFLFIIALQVLDIFKDVIVHYAKKLKEKYFPSKRRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDX5</accession>
    <name>A0A0N5BDX5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDX5"/>
    <dbReference type="STRING" id="174720.A0A0N5BDX5"/>
    <dbReference type="WBParaSite" id="SPAL_0000420300.2">
        <property type="protein sequence ID" value="SPAL_0000420300.2"/>
        <property type="gene ID" value="SPAL_0000420300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="243"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000420300.2"/>
        </source>
    </evidence>
    <sequence length="446" mass="49979" checksum="0418D1E7E38B5F63" modified="2015-12-09" version="1">MNTIPVSSVPEKANDFHYEDKIWNDSSKEKYNSDIVDSNGKIFIIIAILNFLYFLVLNKTSDVFAEVSRDDKDHSFNNSPEGGLHTVVDDILDRINAAASTTKHQTDQEISPVVEENESNGSPHSQNVMEISDVVGKNDNEQYEEEDTPQRNGPLTIPQDVKNNDNERDLDNDDIPKEPEFTPRPPTPPKDLNDDEYQPEVINLGPPPASHHFSTAETPKPILKSSYHHEKAWVDFKTINPKVMDILYWRDPKKSGVAFSLSLLTLLLLTKLSVISLFAYASLLILTGTLGFRLFKAFEAKVKSGDPGNPFKTYLNEQLTIPGEKVHAQVDVIIEQLQAGFAKLQKLFLVENIVESLKFVGICWALTYIGGWFSMLGLSFIIVIGAFTLPKVYEVYQEPIDAYLKIAKEKAQEVTKQIEEKVPCLSKITGSCPPNAAPVEGEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE12</accession>
    <name>A0A0N5BE12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">cAMP-regulated phosphoprotein 19</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE12"/>
    <dbReference type="STRING" id="174720.A0A0N5BE12"/>
    <dbReference type="WBParaSite" id="SPAL_0000423900.1">
        <property type="protein sequence ID" value="SPAL_0000423900.1"/>
        <property type="gene ID" value="SPAL_0000423900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 4" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000423900.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14543" checksum="3C91969E892C399A" modified="2015-12-09" version="1">MDIKLDEEKKQEELLKAKSGDLPSIPASKFLQKRLNQRKFFDSGDYNMNKEQEKKAHPRVHPLNQSCNEPVPPPSKELDAINEDGLTVPTPENVPQRKSSILFPDVHSKLSPTPHIHHEQDELFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE25</accession>
    <name>A0A0N5BE25_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE25"/>
    <dbReference type="STRING" id="174720.A0A0N5BE25"/>
    <dbReference type="WBParaSite" id="SPAL_0000425200.1">
        <property type="protein sequence ID" value="SPAL_0000425200.1"/>
        <property type="gene ID" value="SPAL_0000425200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="8">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="6">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000425200.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="54809" checksum="FCC30588C4E334C8" modified="2015-12-09" version="1">MHFFFVCFDIIEIDYVEDKDVLKRLGKENLKSANEEQRNFINRILNIIVNNLPDKRCFFLEGPAGTGKTFVYTTLYYLLRAEDKIVLNCASTGIAATLLRNGQTVHSMFSVPITLFDNNFRLSKLNKLRTTMLEKASLIIIDEAPMLSKYVIDYLDQQLKKVCKNDLPFGGKVIICGGDFRQTLPILPNSTRHQNVLFSIKYSPLWNVHFETVKLTRNMRVKEDEIDFAKWILDIGNDALQKNEDGEVDIPLNIQSTGNLVNDIFGAKNESILEKSNYAILAPTNAIVESINNEVLNTLPGDVEKIFSADSIRKDSDTDENYYNMPIENLNQLTPNGLPPHVLNLKVNAVIIVLRNLNIKEGLCNGTRLRIIKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEYPFTLARKQFSVRLAFAMTINKSQGQTLSKVGVDLTTPVFSHGQLYVAFSRVKSPDCLFVKTESDKAKNIVYTEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF28</accession>
    <name>A0A0N5BF28_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF28"/>
    <dbReference type="STRING" id="174720.A0A0N5BF28"/>
    <dbReference type="WBParaSite" id="SPAL_0000459700.1">
        <property type="protein sequence ID" value="SPAL_0000459700.1"/>
        <property type="gene ID" value="SPAL_0000459700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="174"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000459700.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53423" checksum="921EDCB5481FECC5" modified="2015-12-09" version="1">MKDDAKQSINDALKDNEDINTPQIANEHSFLSNKDHSSCINNTTLFHTILPNNFNIRDKQQLDLEIIAAMKSKIYDNKPIQVINGIVHVQVPSKEGGNDLLPIIPSDPETCQLVFNICHTQSGHFGLEKSLEFLKTYGYLKKSRKIFEQFYKECITCAEVNSPLQKHCEMKTVQYSRPFENLAVDICGPIQPASQRGNKFIIIFIDSMTRFTMAYPIKKYDYEHVIECLQDLVFTHGAPVSIRCDNAPNFKSHSWKDALDVVNINLQHSTEYHSRGNSLAERALRNLQDGLKKLIKEDVLNWDKYVKPLCYFYNINICKSTNTSPYFLHYLRQPYTDLNKLLQTDVKYKVDINRPLSEIVQYAKKAYETANAVILRSSEARKALVNPKYILEQSHFKEGDKVYAKLPDFSRGRKLAKKWKGPYTIEKMEDAVAFITLDNSPKKKIRKLHIDKLKKFRSNKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFC0</accession>
    <name>A0A0N5BFC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFC0"/>
    <dbReference type="STRING" id="174720.A0A0N5BFC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000468700.1">
        <property type="protein sequence ID" value="SPAL_0000468700.1"/>
        <property type="gene ID" value="SPAL_0000468700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000468700.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52334" checksum="061644F8BF42343E" modified="2015-12-09" version="1">MENETILVEFINENGDALNSDPLLLPLSATNFQLQTLVNQLLENEDPVPIDFKTEDGSNVSESLIESLQKEKINTEVGIKLFYYPQAVFKVTPVTRCTSTLPGHGEPVISVQFSPDGNNLASGSGDKTVRMWDVLTEMPKYTLTSHKHWVLCISWSPNGRKLASACKNGQICLWNPDNGKQIGPILSGHKQWINSLSWQPAHVDPESRLLASSGKDNTIRIWDTILFQTVRVLSGHTASVTCVKWGGEGLIYSSSQDRTIKVWRSSDGVLCKTLTGHAHWVNTLALNTDYVLRTGPFDLKNECRVNSDSEIKNVALERYNSIKGPGHEKLVSGSDDFTLFLWEPYDNKKSIGRMTGHQQLINQVLFSPDSRYIASASFDKSIKIWDGKTGKYITSLKGHVQAVYQISWSADSRLLVSGSADSTLKVWNMKTKGLMIDLPGHGADVFAVDWSPNGERVASGGKDKVLKIWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFY3</accession>
    <name>A0A0N5BFY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000489150.1">
        <property type="protein sequence ID" value="SPAL_0000489150.1"/>
        <property type="gene ID" value="SPAL_0000489150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000489150.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8652" checksum="E951EB5EFC458584" modified="2015-12-09" version="1">MERNLTEDDGSVTQSDDREAKQIFNSLYRKLTEDVCHPPFSSKNPAESFERLNLPDNYTENTTMIKLFRFTGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG79</accession>
    <name>A0A0N5BG79_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG79"/>
    <dbReference type="WBParaSite" id="SPAL_0000498700.1">
        <property type="protein sequence ID" value="SPAL_0000498700.1"/>
        <property type="gene ID" value="SPAL_0000498700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894544" evidence="3">
        <location>
            <begin position="24"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000498700.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32311" checksum="D1CC1D4EC51135BD" modified="2015-12-09" version="1">MKILQFSLFIVIYIFAIISLVVSESEEQTTPTTVDTTTSNNAIVHNKIKFLSGNLSGNKTNTDGKRKIKARNQNKLFKLKKLILETENKTSTSDKNVSYTNKKSNENSTESATTLRNKTKHQLMILQKELRRLTKIADKLSELNEIYSATKPQPTKKKTDGDIKGKKNSTGKKGISNRHKPHFRISHGDGDSGKRLNELQSKNKGNDENKPGKWKGGRKKNQTTVKPNSNNNTTTPTPEKGRVVTSHINTRQFKRKNNKKNDGNTFLTTLSPKTVNTSLPPPTTILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGK7</accession>
    <name>A0A0N5BGK7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bap31 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGK7"/>
    <dbReference type="WBParaSite" id="SPAL_0000511000.1">
        <property type="protein sequence ID" value="SPAL_0000511000.1"/>
        <property type="gene ID" value="SPAL_0000511000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894488" evidence="2">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000511000.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24821" checksum="4C4BF2F141171DBA" modified="2015-12-09" version="1">MTRHSNFLVLSLILILTANCILPQRTTTTKDPVNERKKLYEKNLKNAPSKMFRAIVNIVIMVYRGTFSIAFKMQENFISGWSYLKEGLGMITDTIVEEEDEDGTPSNDPSTTADKKTYAKKIINEILNTVKAYIGEDAPLIKIAVLHGIGITMFYLLSICFIILRSIFFKTYSLQSSRRRRELNSRNLKENFIPANLADHKKTYHFDENRDSTIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGW2</accession>
    <name>A0A0N5BGW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGW2"/>
    <dbReference type="WBParaSite" id="SPAL_0000521200.1">
        <property type="protein sequence ID" value="SPAL_0000521200.1"/>
        <property type="gene ID" value="SPAL_0000521200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000521200.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71117" checksum="B5563B33ECD7A152" modified="2015-12-09" version="1">MEGKEENDSCKNQSKTTHELPPAFKNIYNSYDAFFDSSKEVVVLRNVFNEIREKNDSEFQWTERDIINATTIVDNKEIMSMIIGNLPKLIDRCSLELTCSTFYRICNDKSSQITPFNVEEGVQKYIRDGSKVKCCQNTVYLNIPHTSDSVKSSFMKKAKILETYFKRKPKLVIKNLPIEMASDLNSIPTLDNIKTVVFKTNSQPIFSMHLLNSIPSLNPKNIIFEDYGKSSVDIDEEVVEEMKIDIPILVRNVVLMCGRKNSSCLLKCFEKLKKGSLDQLTFGRFFTIGIVKKDQLLMASHLASYFKNVKVIFKNDISGDVNNSIFKLLDKFNMTTTTPVTYEISFYMSSVGNLFSQILAGQFKEKKDLIWPKYSKISVFRVFRKRQNENGKLTDEEVESLGLGLSQMLNLTIFEFQFDLIKTLDEFSVICRGFRKSIRNIKIYGCSKFSLDHLNILSNGVESLENFSIEGISCSAIKLSLIMSSFNTLKGLHVDFSENYFFENIIEDIVTIDETKGGELVKWPNLDLLDIICIIKKSEYDILERMNRNTPRRSGKFLYFKSSKEATPYCESYCPFYRIIIQKSSKNFGIFRSIFSQDTYEFRDETYFGYDPRSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIJ2</accession>
    <name>A0A0N5BIJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BIJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000577400.1">
        <property type="protein sequence ID" value="SPAL_0000577400.1"/>
        <property type="gene ID" value="SPAL_0000577400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894570" evidence="6">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000577400.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29112" checksum="838D23F8EF12D555" modified="2015-12-09" version="1">MIMLSGLHSFSFIFPFLVLTLVKVNGERAKVTDIHGNDLEPLENYLEDCSSGKKYGLVDGMLEECDKWKIEAGNGFRNPEDDAYEEMKCKKLRVHGEIRDGKCVCINKWTGSVCHIYKGCPEGQSLYKGACTANICQNDGVLSIGSVHLECRCPAPWQGRYCEHLACWRNTDKAEHDKRFKNAKTKCECGSHYTGENCDQIISCEKGNLTNGICECPKGYYGEICHIKCPHNAETCSASIIGYAVPSILLIFVTLTAYILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJU6</accession>
    <name>A0A0N5BJU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Junctophilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJU6"/>
    <dbReference type="STRING" id="174720.A0A0N5BJU6"/>
    <dbReference type="WBParaSite" id="SPAL_0000621500.1">
        <property type="protein sequence ID" value="SPAL_0000621500.1"/>
        <property type="gene ID" value="SPAL_0000621500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000013">
        <property type="entry name" value="Putative Junctophilin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="621"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000621500.1"/>
        </source>
    </evidence>
    <sequence length="900" mass="101678" checksum="7474685E2CBB5A86" modified="2015-12-09" version="1">MNGGRFDFDDGGTYCGGWEEGKAHGYGVCTGPQGKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGIENRGKWIYKGEWTQGYKGRYGQRKSLNSPANYLGTWSSGFHDGYGTETYVDGGSYQGQWQRGMRYGYGIRKSAAYGVAVKFRSRSHTNASMTSLRSDYGEEEEAKGKEDEIDESEACKGGFVLRSRSDAPQKRRRSLSERSLAVKRTILSGLRIKKQHSTGDIHQRVASISGSLRSSGSTMSCASVESHGMACNKAMDHEDKIDEKATEIYRGEWKNDKRSGFGICERSDGLKYEGEWLNNRKNGYGITYFKDGTKEEGRYKNNILIYSTRRKGIMFVRSSKLRERIESSVEAAKRAASIAQQKAEIAITRTMTAKERAELSMGVGEQSREDAELARMHAKNFDPSYKHPGTDTLKVNRQHNRQLLSHISGNTTNHVSFDSSLDPVSNQVSFDYSVYNQGNNIGGNDNINTMERPPTFGQYSQHPSQDYTTPEEEQNISLGQKVQFQQQYHNNDSSIQHHNPNHGHNNPHQSQVHYYQYNTNQLGSNYPLSGQNPHKMSSQYYSTTNTTTNPTTTITNNNNNVVQQPPTTNITSSISQDVVNHHQQYNNNSNITSNNDIRKNVTTDDNNTLTQSGRKQSNNYEISGGNSNSNNNDDNLNTEQQHTVKNNPHNSGNFSNSSSLKEDLSSKGQTLTPNRYNTNLSKTSINSSNFSLNDDHYEQYKYLTGESDQGLKLRRNRPSLMRQADVNNPDSNHFINRRSTLAGSRDRPPIIQDSNAIGALKKEQSSSFDRGSLPNLADLSQAPVTMHREDASRLASQRRQEAQRLLEEEEMLRNNPFRYFTHPSLRNWLLRYRIPLILIFANLFLLYILVQLLTYKKNSNTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK11</accession>
    <name>A0A0N5BK11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK11"/>
    <dbReference type="WBParaSite" id="SPAL_0000627700.1">
        <property type="protein sequence ID" value="SPAL_0000627700.1"/>
        <property type="gene ID" value="SPAL_0000627700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000627700.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9664" checksum="8B08F3A4E555B0EF" modified="2015-12-09" version="1">MNNDKFMELVNLKKENIKLLEDISDKLDKVAHETYETYQQAQKMKSLGESIETCLKKNDKRTCELLDIEYSDKPVKKNEPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK12</accession>
    <name>A0A0N5BK12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK12"/>
    <dbReference type="STRING" id="174720.A0A0N5BK12"/>
    <dbReference type="WBParaSite" id="SPAL_0000627800.1">
        <property type="protein sequence ID" value="SPAL_0000627800.1"/>
        <property type="gene ID" value="SPAL_0000627800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894382" evidence="2">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="128"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000627800.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30614" checksum="46528D6483279490" modified="2015-12-09" version="1">MIYSPFIFLLLTLPGLLGFSNGQRISYSWRTQNGVTVYSFNGKEYPSLQAVMEAIKRQFPNVEFKSPNSGTSTNSGLGNKTPTSGYSKNNGGFDITPYKGNNTFSNMIFDKVWAKYNYDKDSRNGFTNMKKRFLIESNKYRRAHHARDLKEDSGLAAKAQKYAEYLASINKLIHDPQNSNDKTGENLAFGSPWISHLAVKNWYDEISQYDFKKPEFSYKTGHFTQLVWRGSTKAGFGVAVSADGRRVFVVCKYTPPGNYAGEFQKNVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKI1</accession>
    <name>A0A0N5BKI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKI1"/>
    <dbReference type="STRING" id="174720.A0A0N5BKI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000643800.1">
        <property type="protein sequence ID" value="SPAL_0000643800.1"/>
        <property type="gene ID" value="SPAL_0000643800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894514" evidence="1">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="87"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000643800.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26951" checksum="B4452593FEFB7CB7" modified="2015-12-09" version="1">MNINFILTLALFVFMSIISLEGKTIHYCIKRINGRQVYIWNEYPNMHFSSYREMMDFALYGVKPTTGRPTTTTQLVPVKRIKIDIKKYNKLFLEQTNKRRKLHGVPPLTFNQKIADAAQKWAEECARDNKAKYDYDHTYTTNYQGFSIQEYKNAIKHWYNEKNVHDYSKNYFTVASRHFALLIWKPFKQMGCGFAQGAREVFVVCKYSPPQKSEDGYIKNVPKPKSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKR5</accession>
    <name>A0A0N5BKR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKR5"/>
    <dbReference type="WBParaSite" id="SPAL_0000652000.1">
        <property type="protein sequence ID" value="SPAL_0000652000.1"/>
        <property type="gene ID" value="SPAL_0000652000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF55">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000652000.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18429" checksum="58B80A095714DBC0" modified="2015-12-09" version="1">MKESLKIPFFLNILGWILSLLVMVVDVIVIRDWVSGKPMDLFFRAVYSAFSKIGWGVSLSFIVISCFYGHGGIINRFMSWPYWSPLGKITYSTYLIHLMIIVYVVGGFEGRFVFVSIWNTFIYINLPIIVLSLFFAFFWSAIFEIGVGRIEDPLLGRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNF5</accession>
    <name>A0A0N5BNF5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNF5"/>
    <dbReference type="STRING" id="174720.A0A0N5BNF5"/>
    <dbReference type="WBParaSite" id="SPAL_0000743400.1">
        <property type="protein sequence ID" value="SPAL_0000743400.1"/>
        <property type="gene ID" value="SPAL_0000743400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000743400.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36515" checksum="FE2128499DB7B2F2" modified="2015-12-09" version="1">MDSYEVEYEDDPNDTAIPNIQKITRGNNTLPEYGNRQTMNLNNLLYTNIIESVYWKEYLHSLTTFHQVQDEIIKKVKYLEPWEHGSRNQSSSCIGVRGVSAGGRVTTAFCLLYKLFTLKLTRKQIVSMINNEQNTYLRAIGFLYIRYCQPPKDLYDWFEPYLDDKNTIVIKSRNGSEVTIGEMVTQLLTNLDFYGTLLPRIPVPIQNIIDKKIGVDDRGDYGRDRSGKYSSSDKVSDSRSHSRRHRRSSRSPHDSRREDRKHRSRSKSHERNKDYYSSKLTKIKDKVCSHHRRHHHCSKHQRTCPKKVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPB1</accession>
    <name>A0A0N5BPB1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPB1"/>
    <dbReference type="STRING" id="174720.A0A0N5BPB1"/>
    <dbReference type="WBParaSite" id="SPAL_0000773700.1">
        <property type="protein sequence ID" value="SPAL_0000773700.1"/>
        <property type="gene ID" value="SPAL_0000773700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="66"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000773700.1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="122284" checksum="E3136197E9EC4A6E" modified="2015-12-09" version="1">MEGSIIASSALEGFKLLVPDNEKGFVIGIFESFINDKIIQLKIEGSNESKQFPLSQTYTPNFEVNKDFDDNCMMDSPNLATLFLNIKDRFFKNKIYTYVSSILIAVNPYKHIYDLYTDKMIKKYCNNSYALTSPHIYAIAKKALNNIKLFNKDQTIIVSGESGSGKTEAQKEILKFICNTWYSNDKLIERKILYSNLILESFGNAMTVKNKNSSRFVKYISFNFDNGHKVIGGKVIYYLLERSRIIYQTKHERNYHIFYQFILGANDKWRKEFNVNKIDQFEYLSKGCQSILNYGKDCIIDDVNSYGRLIEALKEIGYNYDNIKEIFKILSGILHLGNIKFYHKTNDGECDVKNEDSLKQVSLLYGFECDMLKNALTSKKIYVSGNATNKDPISIHLKYTEAVNARDALAKKIYTRLFDSIVLSINDKIKATSSKYHSLSVLDIAGFEFYKINCFEQLCINYTNEKLRNFFNKIIFINEQKLLNQENIFTGKINFTDNSECLQLFDSKFDGIFTLLKEETYLPQPSSIHFTESVFNRNNKNKNLTTGKEYDMKGYEDNEGFVIRHYANDVFYDTKNFIEKDNDILYSSLEDFLQQSTNIYFKQLFNSKNPNNLSKHNSPTISLTFKHQLDELLREIESSGIHFIQCIKPNDLMNSNVFDGNKVIKQLSYSGINDALFMMNVGFPCKIDINELYKRYEEYLNGWMKKIDRRVFLVALFNVIDLDKKMYKFGVTKIFFEKPAYEKFDKLLKHEEIMVSANKVKCHFHKKKWKRIIFSIIFVVNISKNFSKKNNAAIIIQAYVKGFLLRKKVKKIFELYNELCNFSEIIDRNMEMIENFSSKRKKNLCERSKEVLTLIIVAKSCCKKLNYKKVHYLVKDHNEISYKMFNLLSSIENVILEDELNKHLEIDEKDLDEHYNLRSVGEPTSTILEDKQKHTKKYKKLNDSIKKVKNIKNSIICNFVDDDFYNINELEEKLLNGKICSKTDDVSMEIELYDKEELKKMSFKRLKQNLDTLMDRRRREQCKEEIERRYSQLKNRKIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPP9</accession>
    <name>A0A0N5BPP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPP9"/>
    <dbReference type="STRING" id="174720.A0A0N5BPP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000787500.1">
        <property type="protein sequence ID" value="SPAL_0000787500.1"/>
        <property type="gene ID" value="SPAL_0000787500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="6">
        <location>
            <begin position="254"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="594"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000787500.1"/>
        </source>
    </evidence>
    <sequence length="846" mass="96137" checksum="4539A95884063848" modified="2015-12-09" version="1">MKRGYPSTESFSGNFTKLSYIESSKSYDIEFVDITNISEKLKGKPKYCFRKDSTNLNNTSVTNVSNLTGRNNVIAIYRGRSEDKCEVGIAYMDFRTATLNLCQFIDTPTFEILKIRLSMLDPLEVLLCDPTEDTGSHTDVIIEIAKDVCSGPEIMAISRKFFDDVKGTRLIESVASPEASNIDKTTMKQYLCISAAYCLISYLEQILNLSYAAESMQVLYECLKDRCMIDLQTCKNLNVIKDLKEKATANKNMVISKTLFSVLNTCSTDGGEKTLRSNLLQPSCHLETITKRQNAIEELKLNENLLFKIRSQLTHVKNMEFIIASCVHIDKKNETCASRRKIQELINLRETLDKVNSMRKLVTPIKCDVISNLAKALYDKRLEEILNLISQKIDIDFKDQRNVNQFVKKNFILYAVKSENKILKIARETFEQIISEAEALTEKEVNNLANCRLNFTTSRGFFYVIQTNGIPTRSNIPAMFLNICVKSTNITFTSRGLIKLSDRINDCINEILIFSNTIIDDVLLSIRKLIPILYKVSEFISYLDFICALSYYSINRNTVKPTFSNCLIVEKGRHPLLEIQEKVVPNDVYIAPETCFMLITGPNMSGKTTYMKQVCLLQILAQMGCMIPADSGKFPVFKRIFSRLSYNDDIVTKLSGFAMEMSEIRPILKNADEKSLIAIDELGRSTSTEEGLAISYAIIEQLIASRSFTIFATHFLNLSKMALSFSSIENYHFSSDETNNVNDVSCRSNAFVIKKGQYEGPLFGFSLASACGFPNDVVESAKKTAEGIRNEELKKYRTNEKFIYERRLIKLGYKLKRCISIADQHDPSEIADYLRNLKNEYLKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ29</accession>
    <name>A0A0N5BQ29_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ29"/>
    <dbReference type="WBParaSite" id="SPAL_0000800200.1">
        <property type="protein sequence ID" value="SPAL_0000800200.1"/>
        <property type="gene ID" value="SPAL_0000800200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009924">
        <property type="entry name" value="DUF1459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07312">
        <property type="entry name" value="DUF1459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894765" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000800200.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9436" checksum="59A1EFD08C245ABB" modified="2015-12-09" version="1">MNSKLILAILTFIFATVSAQYYYPYGSYYGGYYNGLYGYNGYAYPGYASYYPSAFATGYYGFGSNKGNAGEEQKPQANVKLTNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQB4</accession>
    <name>A0A0N5BQB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQB4"/>
    <dbReference type="STRING" id="174720.A0A0N5BQB4"/>
    <dbReference type="WBParaSite" id="SPAL_0000808050.1">
        <property type="protein sequence ID" value="SPAL_0000808050.1"/>
        <property type="gene ID" value="SPAL_0000808050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000808050.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11673" checksum="8B69E4E70E49588A" modified="2015-12-09" version="1">MTQITSIKNECTYSDTDADKISSTSNTTLPPSKTASEAASFPNCKIEHRMLINPPIQGYAICNESLSNPQPFSQMPTNQFSEVIIDPNVSVSITMNDYEKNFMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQF8</accession>
    <name>A0A0N5BQF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000812300.1">
        <property type="protein sequence ID" value="SPAL_0000812300.1"/>
        <property type="gene ID" value="SPAL_0000812300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894870" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000812300.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14276" checksum="8FFDE53BA0ACFD20" modified="2015-12-09" version="1">MKFLTAILIGLVATTGAKHIIKRGSSYGDEMITPPPYAPEPTTYGAPGLSPVEQNIVEAKQEYAPASETRIEQSGYRKKKSSGYGDELITPPPATAAPYGGEEIPPTSAPEYVPVTERNDYNAGYAPSPQPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQV3</accession>
    <name>A0A0N5BQV3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQV3"/>
    <dbReference type="STRING" id="174720.A0A0N5BQV3"/>
    <dbReference type="WBParaSite" id="SPAL_0000826200.1">
        <property type="protein sequence ID" value="SPAL_0000826200.1"/>
        <property type="gene ID" value="SPAL_0000826200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000826200.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38182" checksum="E88ACCF856F1D44E" modified="2015-12-09" version="1">LLKPDKAKANYRISILNYEGEETNVWHSTGTREFDRNNENFSWGYRKFVKKDFLLDESNGLLVNGCLVIFCEAEIIDLRTENHSNLEIVDSKTENHDKPETSINISIPQSKLLSDYGNMFDSPLFYDCVIKVEDTEIQVHKEILAKRSPFFCDIFKGTLEESQTNIIEIKDFSAEVVRKMLKYIYTDEVPDIQDMANEIFEIANKYELDRLKAIAEQSMCNSLSIENVCERFALSDKYPTERLKECCEEIILKNMEYLKETEEWKKFILVRPLLLQSLLFKLSNISSTRKKSNLLTWYQGLGIVTIYCNFINIWNGQINYISLLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR46</accession>
    <name>A0A0N5BR46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NFACT-R_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR46"/>
    <dbReference type="WBParaSite" id="SPAL_0000835000.1">
        <property type="protein sequence ID" value="SPAL_0000835000.1"/>
        <property type="gene ID" value="SPAL_0000835000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000835000.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21271" checksum="350DE43DFA4320AD" modified="2015-12-09" version="1">MNNRIYVFPKSATSYELANEIGKTIISYSIDENFSQLLVLYSNEMDWKRVNSTSQLFVLYKITEEDYTDDFGKKLKRYYAIKLVIYHNIKKKIPKSFAARFFSVKQSDGTLIYHGILPNMKDDQLEIISLNNQIKTEGYEDFKDLKNCLGVATIDGKESCLKSNSRNKIAIIFKNRVVVMDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSR2</accession>
    <name>A0A0N5BSR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSR2"/>
    <dbReference type="WBParaSite" id="SPAL_0000890400.1">
        <property type="protein sequence ID" value="SPAL_0000890400.1"/>
        <property type="gene ID" value="SPAL_0000890400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000890400.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19156" checksum="D3CD0AFE239124A9" modified="2015-12-09" version="1">MSKIKKDAIKPRNEKLLSHNNIKNSSELPSVKETMKENIAAQHDSNEKEVTNPDKQTLLKAKKSSSNKSKIKGNSTEKSKENKNQSSKKTNKTQSSKKKSKSQSSKKQTASYNSRQDILKAQLQNFQLQNSINNDGGAFDKKIKISGSLKEKKDSSVKKNNKSSSKKKKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTC2</accession>
    <name>A0A0N5BTC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTC2"/>
    <dbReference type="STRING" id="174720.A0A0N5BTC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000910800.1">
        <property type="protein sequence ID" value="SPAL_0000910800.1"/>
        <property type="gene ID" value="SPAL_0000910800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000910800.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52052" checksum="8698A413D9A5AAC3" modified="2015-12-09" version="1">MVLNCTICCDPYTGPGTEHAIYSTICGHLMCKACLETWRTSKTAKSFTCPRCNRKLTKKEYHPIYDLPDEFFSGTDEPETSEKIISDTDIMGDFLKDNSSFQVRFIKRLEQECGGAVRLLDTHNKYLLLVGSLSPTSTEGQFLKIIDCCTGKTHHAINIGDTLCTAVAFNKYREEFIEYMVGFEDGSLIHTTLYGTSEMNTAVNREFKENGTIHSICFIGPEKYAYSAGPGGLYITNLSGGPKKDNWYRVETLNEREIVTNISRLTDKSVLGIVRGRIYVFNEYDESYTLCADSGDVIGYAVDDGALMILVFYAKKNHYGDSTINNQSYVLRRILQTRCKKSEVSNRPMFSAFTRKMVSNKDGKFPVPLSSNILVRNLEGDNVYECSLIPNMRTQTLDVVHFADTAKVIGKEVFENMDRCLGANFVSKPEWLVQNELIKLQTAIIFKSNFVIFDIYCSTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU20</accession>
    <name>A0A0N5BU20_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU20"/>
    <dbReference type="WBParaSite" id="SPAL_0000934400.1">
        <property type="protein sequence ID" value="SPAL_0000934400.1"/>
        <property type="gene ID" value="SPAL_0000934400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000934400.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45729" checksum="3CDEFE02DB03938C" modified="2015-12-09" version="1">MAKRKHTIISKEGNKAASDEKDISTITESSFYENIEQQSNKSSNSSINSNDENVDSKKRRRGKCTTENNKIKKEEIVEAAVLRLNNIFDSSWQQIINDPKSKKMPHILKEAKFTLAKIHYERNGTTLLKSIAPTVNLFEKKFLRSEKDREDDNNNNKNNNKSNFLLSVAASVRSLHQNEKRRINKLQSIHGTTVENTKKFKKLVNLNVDEMKSFIFNNENEGIKKLISMVEKRHNYINEFSYESLFQQFPKLSKRTSDLFEADGLYFATKGINFEALYKYNERIWEKIPQNIFNNFFSEFSIENCENNLIKIKYKNIYHEPSDKATILKQIVLLALTTKSYLVPVKEKYFVDVLIKLVNGRADYTCKSKNTSRYFGSKCLILEKEITRESSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU68</accession>
    <name>A0A0N5BU68_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH_Tnp_Tc3_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU68"/>
    <dbReference type="WBParaSite" id="SPAL_0000938800.1">
        <property type="protein sequence ID" value="SPAL_0000938800.1"/>
        <property type="gene ID" value="SPAL_0000938800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938800.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17565" checksum="B6105AE218B2DF7E" modified="2015-12-09" version="1">MLFAEVRQKILDYSRENKSCRWIAKKLKIAHTTVSRVLKSGRTKNRRIRSNAGRPRKLNRADKLKIKRVTMNRIQKNSMVNSRIIKNELNLDVSLRTIQRKMKAMDFTYDKIERKIPLSKSTKNERIKFCKKMLTEDRRINKFHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUC8</accession>
    <name>A0A0N5BUC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000944900.1">
        <property type="protein sequence ID" value="SPAL_0000944900.1"/>
        <property type="gene ID" value="SPAL_0000944900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000944900.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9809" checksum="06111B8F7A7EAB88" modified="2015-12-09" version="1">MMTSTKGILIFFTFLTIIASTILPVTCAWTYFVGGNTELGQYDSAQDIVDAVNFCNALPSFRNTNRILKYREICRKIIELINSSGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUJ7</accession>
    <name>A0A0N5BUJ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPI inositol-deacylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUJ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BUJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000951700.1">
        <property type="protein sequence ID" value="SPAL_0000951700.1"/>
        <property type="gene ID" value="SPAL_0000951700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="6">
        <location>
            <begin position="79"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000951700.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="64128" checksum="127EE8CED2119F44" modified="2015-12-09" version="1">MLTRLSTKDILRILYFIVGIWIVFDIRNCRSYFKHSCDMTVMYRMPQLRTVHEDNETNYLMYIYGEGQYFRKVADTNKFEGIPVIYVPGNRAPADMARSIGSILQNKTEMRNVPYHFNVFAAHLNEEPSTFDVKTLKKHASYLIRGLKHIDKLYSKRSHKFVIIGHSISGIAIKIALSQSKWLRDNTAFVMTLGTAFKEHQFKITGDFIDLWREMHTMVEVPIISFHGGLMDENAEESFTGNEGGYSYSSQGIDRVWTMSDHNCLVWCNQLQRSISRLLFEYAEDKLDKFSRRNIDKVLDKIFNSTTFTYPVIEMNFINDRLVKIDMKETSNGLLLYVIRKSNKEIAPLYETHYSSQLIPKKDLFYDYDMRYTYSLEYISSQSQYYIDKEASLSIVPENEISILESSVVTKTVKFPEKDNIKVYTIPFLSPNIVYRVMIKNKQSSPPKMYFKSNLNEAFSQNGILIFNYFNEEDNEDGKLFIMPQPGVFKDNKMIEVNINVEIGLTVIRVIKLNITNVPFILSFISLLFSFKSSDLGKFLAFNFVIFYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUR0</accession>
    <name>A0A0N5BUR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUR0"/>
    <dbReference type="STRING" id="174720.A0A0N5BUR0"/>
    <dbReference type="WBParaSite" id="SPAL_0000957900.1">
        <property type="protein sequence ID" value="SPAL_0000957900.1"/>
        <property type="gene ID" value="SPAL_0000957900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="240"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000957900.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49300" checksum="35B52C850D5AD827" modified="2015-12-09" version="1">MSSNVPVVNNNSMPTSLFGGTSNGNDIIQNFGVSAQANNGLPNVEHHTISNASIEVVIDFTRPDGQRTRPLLVEGKRLYVDEHYISVWSPVLRAWCIECPDRELILANVQYDHILEMLQAIHPTYKDIDDQSVHILLPLAFDYQMEGLLHRCECFLVNHRLPFLEKIWLADRYKLNRLLGLLIKEMRPNSKVDLSGSRYYGLSDRVKVLLLERLHGAAAPEDILEQPLDLEKFYRASDLNFASIRSKTGRMYYVNPYYLAAWSNIFQERICFLRNQEELYCPCTHEELKAFLMAVYPPQLRITETNIGPILVAACKMESPGLLKKCAQLLLSPSTKLSVFVRLSLLDRCYLHEMLSTCLKMITRAEQNTNNLQIGNHGKITDQQNMGQMIHSNVSINQNLQQQPSQGIGQNPGYTIGSNAGNSPSHYKPGTMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVA4</accession>
    <name>A0A0N5BVA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PlsC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVA4"/>
    <dbReference type="STRING" id="174720.A0A0N5BVA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000976900.1">
        <property type="protein sequence ID" value="SPAL_0000976900.1"/>
        <property type="gene ID" value="SPAL_0000976900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF14">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ACL-12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="153"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000976900.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48847" checksum="24A418B666DB6602" modified="2015-12-09" version="1">MITKTIDDHHQHDGASTIILNSKKETTEGGSTMLQGSSGNGNNGTTKTNEIITDDTLGSDEEYVPLSNFSNFINVSIAIMWLTMTALIVPICVVLIRYIFLEPIRWINHKWFNYLEHKVCHLVNDHWVGAGAFAGLQVIEYGDDLSKIQDERVLFLPNHLGLLDHFILMTSFFNKNTLAGRYIWVIFNIWKWTPLGFMWTAHGNFFINGGAGKREKVLRDFRDHLNSIYWKNDLGYIVMYPEGSRFYLIKESGAKFALKNNLEPLTNCAYPRTGAAKAILDVVGPKNVDKDDSSRKPIEYLVDCTLGYPKGIVPDIRDALLQEWPRGNSKVGIHFKIHKITEDMCNEDVLQQFLYKCYEEKDKLLDYYYKHDTFPNTKARPVSFPWSRMIFVESFWLSIFFASYYFIIKPLSIYCYQMILLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVG6</accession>
    <name>A0A0N5BVG6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000982400.1">
        <property type="protein sequence ID" value="SPAL_0000982400.1"/>
        <property type="gene ID" value="SPAL_0000982400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000982400.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33530" checksum="3E82181569365AEC" modified="2015-12-09" version="1">MIITGANCFVLLRNKKLLKQNYAYVFIAFTAIGNLLQLSAHFISGFYIIFSISPPLHFVMLQGSILNFGFDVTCILTLALSFNRLFLFFNFHGVLYIILKKLTITIIAMLCLVAIFYLIIPNFDFFKIVFNVKNGVWEYYTVKENFNRFNFLEGRLMVSVNLASVLILVLIACKIVYQKLTTESYNNSKKIKFYDISLFLQALFNFLCIGFVQVFWQFGDVWFPNSTYLYTYLNYLWLNVAGRDSVFNLLLLREVRLPILVILKYYKTSAKVVQPQTTTRNMKNNVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVX5</accession>
    <name>A0A0N5BVX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVX5"/>
    <dbReference type="WBParaSite" id="SPAL_0000998100.1">
        <property type="protein sequence ID" value="SPAL_0000998100.1"/>
        <property type="gene ID" value="SPAL_0000998100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000998100.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32386" checksum="879F5496AF3D7786" modified="2015-12-09" version="1">MTYHFTLAVTKYSHTETSRKFSAFLSQIRDAFSIDGVTDENIKFPLLRSRLDDKTREMIPTTKPDETFEQYLIRLAAIFDDTLITNDLETQYSFFKLNFSSDKFEETLREFVQLHETIYRDLPAELNFQSFRRRLLDLLTPKPNLFKVILNSTATTNPTLVTTLVHFFKANGLLHKHSLDTCISTMDNYISTSLYTKQEHISSPNTFTVKNEVNNTSTTTVQSSPIIIRQTTMNNISSKTIMDADSNATYIDPTTKNKIILSSVPESINQIPSNGYLYATVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW40</accession>
    <name>A0A0N5BW40_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cathepsin X</fullName>
            <ecNumber evidence="3">3.4.18.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.18.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW40"/>
    <dbReference type="STRING" id="174720.A0A0N5BW40"/>
    <dbReference type="WBParaSite" id="SPAL_0001004400.1">
        <property type="protein sequence ID" value="SPAL_0001004400.1"/>
        <property type="gene ID" value="SPAL_0001004400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02698">
        <property type="entry name" value="Peptidase_C1A_CathepsinX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000158">
        <property type="entry name" value="CathePsin Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033157">
        <property type="entry name" value="CTSZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018724277" description="cathepsin X" evidence="11">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="178"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001004400.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49400" checksum="5604C0EB0B401A67" modified="2015-12-09" version="1">MRAFIFLLETIFSFVICGQSKSWFEEKNVILQQKNQLNHGFDFVLKLEEDSNHIGFEFMDMIPEPNFNNDELLSMEKNKNEYKSNSKVSNKVNYDTKKKVENNNYINDDNVEYESGDTKEEIKKFMDENDGLYKLYDNYETREYARNHRGPCYRKNMEKMGTKTAPRSWEIEGFEKEIPKTFDWRNVNGSNYCSPNRNQHIPVYCGSCWVFGTTGALNDRFNIARKNKWPMTMLSPQEIINCNGKGSCQGGEVFDVFEHAKSKGLVEEGCSNYKAVNDKCDDYTRCGTCWPDKCEPVANYTKYFIGDYGRVSGRLNMMSEILSKGPIACSMSCTPKFDFGYQSGIYMERTNTTEPNHIVSVSGWGIDEATNTEYWIVRNSWGEAWGERGWFRIITSNYKNGTLTGNDFNLGIEKDCYYADPIVTNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW50</accession>
    <name>A0A0N5BW50_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW50"/>
    <dbReference type="STRING" id="174720.A0A0N5BW50"/>
    <dbReference type="WBParaSite" id="SPAL_0001005300.1">
        <property type="protein sequence ID" value="SPAL_0001005300.1"/>
        <property type="gene ID" value="SPAL_0001005300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001005300.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26673" checksum="4FF970A955DE0526" modified="2015-12-09" version="1">MKLNIAYPANGTQKLIEIEDEKKIRPFYEKRMAQEVEADSLGEEWKGYILRLTGGNDKQGFPMKQGVLTNERVRLLLSKGQSCYRPRRAGERKRKSVRGCIYDANLSVIAAIIVKKGDAEIPGLTDVSVPKKLGPKRASKIRKLFNLTKEDDVLKYVLPRTVSNGKRVVKPRVQRLITSDRLKRQAKRLAEKKARSVKRKEEALAYQKVLAKFAKEKQAEKAARRLSSHKSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXQ6</accession>
    <name>A0A0N5BXQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXQ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BXQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001057700.1">
        <property type="protein sequence ID" value="SPAL_0001057700.1"/>
        <property type="gene ID" value="SPAL_0001057700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001057700.1"/>
        </source>
    </evidence>
    <sequence length="1253" mass="142505" checksum="974CC2B2F77BA1CA" modified="2015-12-09" version="1">MAKDLQDEDRIYMENQMEKIRLAVSGHDIDQFSNKLQRNMMERRQHFDVKDRINIKNTIDFMKKNLPIDETLPLGRKLHAFATANGFEIKYNENEVYLSTSDFLMSITCLNEKAEKVTISWFRCRGDGVMEGTSIKKLINENKFRILSQKMKIYLRTIASTFAIDEKEKLFDILLQDDNEFANLSCDDINSGPIGRFVRRTDLEPSYLCIFCDKLLSLQQGDTLDSSFKCYIDVIGEGTNPITIESTNIKYAYMLRFSQPLLMFAGFANELISYSCKDITNLLKADIYTQLLGITKRMKGLITNEKFYPTVRYLVSDELIYRNNDLVVNNITFTIRDNLIHIIEKIRVQLLVNHLIESIRKDTILENFVLSVNVHDVDIRQPEENTFEFTLLTTNSIKLLLQVTIFTIDNIQINGIFSNGESLDAEIATVFSTALSRSWSIPLSILALMKKLGFDTKYNFNVNCLKKQSSSELSKIGNAWHYFLKFTRKWRKKQLKKMKNSISNLFIDDPVLLNGKAVDILGTLVPIQTDIDMTYLKPKQTFYSPYPPNVNNGQRILLNKNIQKQNVVVDVLPIKPKSDLEAMAEIGQNLSKDNNNSSQRGVLTKYSDNVIKTPTVIGKYPVQNDNSQFVSPLTGGFTPNYQQNSPLKNLAPSCSLNSSDQNITHIKHKKSKSKKPDFAEGVFKVPNINILPVSSATQQSISDDVEMKKNKKDPTNKKSKKVKKSVLSESLPSVIHQQDSLKVTFSRLPLESQSIKPMDEVAFNNGTKVSPNIPKIDFKIKHEILPEEKVATVEKNKDLSENGKVKNKLKKIIENPNQLVKGKLNKSSNEGMCELEVDKVIKQETIISPPNLNISIAGNTDTPVNSELKIKIKRPKITIKNLEPPKPREIQEIKEFKDEINAKILDLSSSSPKIKETSLKKSGIILSKSKSVNDVKEKKSNKRKATDHTPSPRSKSNKKEKLDSNPTSLSEQTPADTFNAIGKKNAFDLLKNFRIPKLEGKEEKVIEKVVEKPIEKIEKLEKVKEKTEKNKDIKFKERHKERDRERERDKDRDRCRDKYNKERDSSKRRSLSPTNRGNLISPSKIPKLENYTSSVKSSNEKAATSTTDITKLVGFIPLAAIKPSAHPTLSQNRHSSRSHSNSSDHYRSGSYSSHSRKTSINETHHSSSRSHHTSSHSHRSSSKSSILPKSPLTSPTSTSSGSKWVKMSQPVQQPIQIQTKIIDPRMRNDQQGKQAFIMREPSPCDLTIDESDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXZ6</accession>
    <name>A0A0N5BXZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001065900.1">
        <property type="protein sequence ID" value="SPAL_0001065900.1"/>
        <property type="gene ID" value="SPAL_0001065900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001065900.1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3504" checksum="76D6837713AC49DA" modified="2015-12-09" version="1">XLNPNQTKPKDIAEENKKMQMYLDSSTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZM2</accession>
    <name>A0A0N5BZM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZM2"/>
    <dbReference type="WBParaSite" id="SPAL_0001121300.1">
        <property type="protein sequence ID" value="SPAL_0001121300.1"/>
        <property type="gene ID" value="SPAL_0001121300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001121300.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35967" checksum="499BD7496BC0E03E" modified="2015-12-09" version="1">MVSNLFNKFYINFNGYDENITGTGFNISLDELKESLYKKNEYFNFKSIKILRFVTIANFLFFDDDSNCVTITDFDNEIKMTVKNAKLKTLLKNINYNNDYEGLLIFLTYEVSHGFISEFILQEVHMLYNFSEYMEQFYKEMFVIRRILSLNLFSSKKFIPFKEKTHFPVSSSKETYIYDNISQSLYGTSVFPSSCNSTPRSRPEKTLKMFLKKFRKNQLDNARLKTQLPESEISIEHNKPIYSNQLNTSDVIGAVELGIMSSINNKIEIEAVKNFLGITKLELVRHLFKLNHLYEFVEDMTNIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0P5</accession>
    <name>A0A0N5C0P5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0P5"/>
    <dbReference type="WBParaSite" id="SPAL_0001157300.1">
        <property type="protein sequence ID" value="SPAL_0001157300.1"/>
        <property type="gene ID" value="SPAL_0001157300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="1">
        <location>
            <begin position="71"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001157300.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59871" checksum="03F263D5E98FF5CE" modified="2015-12-09" version="1">MNIARDRQEIIEKLMRLPSSISTGDYHDPKELNVNTKKQLIKKRWNDLNKFLADNSGEVNQKLKGLEQEIWAKLILMEKDCRIMKAYLRFPTININGGFDDFDGLQVGLARFTSSDNDSSTYISSLDGLLYQLKGGLDIKIDAIGNIFMRKNTSLRIVATSVFDTNQTVELGKDYLKVFDLRKFKKKLWKLIQDGEKDCKILSKYTFIMITLGTEEMYNSNIFSCDLWIALIHIIAVEMIGVILKEEEEKEFCHLNTVNKNVGNFSGNKEGVVKRNGVIKATFVNKNDNKSIIKSESMPLKNDINIDGINNDILKRPSAAKIQRSTVSKDKLVYNENHFSELMYRNGRLQPSKIPLITKTLFTPLQNSLSSTSSGVSSSESGKLLTTNITYKETSTDTSPIRLCRYKQHYDELNNSNILYPYNNSPKNVEVNKKNIEPGVIVKTRRSKIKDDWICHQAIISNKKNKTRSRSVFNERKKEGKNVLVDNDSFSFNFDKGTSTKILMPSEPIKRLAKWKSEKSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C146</accession>
    <name>A0A0N5C146_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C146"/>
    <dbReference type="WBParaSite" id="SPAL_0001172500.1">
        <property type="protein sequence ID" value="SPAL_0001172500.1"/>
        <property type="gene ID" value="SPAL_0001172500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001172500.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9214" checksum="B6F889AF47ED2C68" modified="2015-12-09" version="1">MATNFADNLTQNEFIFRNLLVWRIVWSKNFLLNLMIALDLDKIYKSNEQCNNFQEIFYGKFEVHNTTKSHFDKFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1A5</accession>
    <name>A0A0N5C1A5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1A5"/>
    <dbReference type="STRING" id="174720.A0A0N5C1A5"/>
    <dbReference type="WBParaSite" id="SPAL_0001178200.1">
        <property type="protein sequence ID" value="SPAL_0001178200.1"/>
        <property type="gene ID" value="SPAL_0001178200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001178200.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46728" checksum="7FA5215551C6FC5B" modified="2016-05-11" version="2">MSTETVKTESNDILNIIECDLNKNVTISNEQSMEVDISQNDISKNSINFNVDFKNNIEQLGSINRNIKIYKRKTRKFDMKLSRFKKNLPKDFLNVKDINKRNKKQNNISLVNDILVNVANLNITRKLKNKEKIKKRLSRLSSNIIKCDDVSLDKNCQVDYIVEALESVQETKDSTEKRQKSKKCLKKQKLFPARDEELIPDEHYLGLLYTGCEHCQAMRINNKFAFASYTGQQRDFKTPGPPTFVLHGEAKRVINTAVPKNKDNLSYGQLYFYGPDVAEDIRNKNVNAFNEISVISNLTHIISKINMLALSYKHFGDYIREQELKHKNENKAMPIFKLVLKPPANKNDRVRNLPEVTEIAAIFQSEDGEVPDYNVLLCNKTGKLETLSHYSPLKDPATYPLFFPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C206</accession>
    <name>A0A0N5C206_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C206"/>
    <dbReference type="WBParaSite" id="SPAL_0001202500.1">
        <property type="protein sequence ID" value="SPAL_0001202500.1"/>
        <property type="gene ID" value="SPAL_0001202500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001202500.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27561" checksum="913540F5BB43A6AF" modified="2015-12-09" version="1">MSFLDPTQRLITYVIQSNHNYPNTYKCWKTIFHRFEDALDFSLRSYCYIKFTPPTITKPPLAQKKFCVETYYRTLCYIRNPVTYDIWKAVWRYCNGGCYYKNNFNSARKHYYEEINLYRQIIGCPPIKLYGKLNVMAQHHADTMAKRNKLIPDKNRDYDELNVFAKFGHGIYLMKLIFDSIYFARPDYYQLNPKQTDIERLLSCKQNLIGFGMAKNGHGAYITIKFTSEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2M5</accession>
    <name>A0A0N5C2M5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2M5"/>
    <dbReference type="WBParaSite" id="SPAL_0001223500.1">
        <property type="protein sequence ID" value="SPAL_0001223500.1"/>
        <property type="gene ID" value="SPAL_0001223500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF164">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="278"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001223500.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="53248" checksum="6796D434288250C1" modified="2015-12-09" version="1">MNIFVLILYYFGFIFVSKGFVRNKLGKVTTNYDSELTSKSLLEYVDLTADPCDNFYKFACGKWIKDKEEKSRNETSFSYSDGTTNFKNFINGNIFFVFIYLILEALDGRYNNESIAIKNIYNLKKKCIQLSGEKKKNCESEIREFGKYAFGILFIKKNRIESEKHGDYIVLEDMIKRIKGEFRLLINEKKDIFDKESRDNLLKKLDEMEFTRKFDYNDISSVLLMETCYKGLGISENDSIEEVLKNIKSLSKMNHTFGSCSYNIFQPEKYLGRFVLFNAFYYYYHNVFTTSSNALVEPWFSRYFPHAINYGSIGFIIGHEILHAFDNKAYKYIFGLDGVGEFILTPKSIENFEKKIECFVKQYGNQKERKTMKNINGTLTLSENIPDNGGLIIAHRAYMKYLQSIGGEEPRVPGFEKFTSEQLFFIGNGRTLCEYVSKDQLEKQINTDPHTPGEIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C353</accession>
    <name>A0A0N5C353_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein srb family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C353"/>
    <dbReference type="WBParaSite" id="SPAL_0001240800.1">
        <property type="protein sequence ID" value="SPAL_0001240800.1"/>
        <property type="gene ID" value="SPAL_0001240800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002184">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srb"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00699">
        <property type="entry name" value="TMPROTEINSRB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001240800.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37947" checksum="663CF546F0549452" modified="2015-12-09" version="1">MSNSLIVLVLTEEFYPINKNYYFAAVQYVISMSIVLIPNLYFLYAVLTCAAFKKRKMLKRTVLVSNILNIVYIVTNLIISSYYLNGYHNGGLIRVNICFYMRRIQMMLMTFLVTIPLVFTVERYFTVFSRNNLQKYIAFTVFVVSNFPSFMLFATMFFQSNIVWVPDEICTLIKGATSPVVNQITGLIYYFTLGVPLIVGIINFLMIRRLNSIASTCPSSKSKQNENKTVFTNLIIQTFQPFLGQWPSILFYFYLVSTGNNIYVVWRILDGLTALSLISNILFSIVFIKDVRNTIFRRIGIKAVNEVTKVVTITNDNTLKFKHRKSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3A3</accession>
    <name>A0A0N5C3A3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3A3"/>
    <dbReference type="WBParaSite" id="SPAL_0001245700.1">
        <property type="protein sequence ID" value="SPAL_0001245700.1"/>
        <property type="gene ID" value="SPAL_0001245700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001245700.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29980" checksum="438FF8F5DB65F7EF" modified="2015-12-09" version="1">MYDLKIINLLVYSELFKILCNIMLAYNIIGIELERFFAIIFVKRYEYNKCSYVIFTYHIIMICFLIFSLKFLHSWNDNSLRLYRIINVILEIIGLVLLIKISYIYIYYIKKRQKYYFQVKRYLSTRYQGKENIDIIGSLLQPLGCFFSIGIIYTFCTTLLPLVINIPPMINLSFSILIGLKVFVPFYILFKKYDENFLSNIFSIRFKKTKVVPEIPPTQCQQVDSTLNLDEGKLHFKYLNAFWEDAYKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4C6</accession>
    <name>A0A0N5C4C6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C4C6"/>
    <dbReference type="WBParaSite" id="SPAL_0001280700.1">
        <property type="protein sequence ID" value="SPAL_0001280700.1"/>
        <property type="gene ID" value="SPAL_0001280700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001280700.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25003" checksum="047D40741801B28B" modified="2015-12-09" version="1">MSLKIHCTICTDDFWSGTVSTCPCGHTFHEECIKKWLEHQRNCPICRQKCTTGKLTTLFFSFTGETSQAMVEEKATNSEYKNKITQMTHELEMTKNELRRANNQLDEARSIIETQSTSLIGYENLQKEYEILSNIASDYQNLKNECKKMVRRIKVSDFYKIVSESGDSIDVSLLDEYVKDEDGSVNVTKLLEAAVKENRRMXXXNWNQPSMVHFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4X2</accession>
    <name>A0A0N5C4X2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain-binding protein 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4X2"/>
    <dbReference type="WBParaSite" id="SPAL_0001300100.1">
        <property type="protein sequence ID" value="SPAL_0001300100.1"/>
        <property type="gene ID" value="SPAL_0001300100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001300100.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17592" checksum="F6497D7293E2AAF6" modified="2015-12-09" version="1">VATVAMLTHPRARRAALRRSQSVQTEIDNPLVAVSPLNEQPPLLSPANVQQPLPRPRPATNHTPQQAPAPRRPTRDDQQHQTSNLRPRVLNLRPASFGIQPIMVLAPPPTPNWGATPIAGNINGPQGNAPPPTSGPEGAQQSQEVPTTTYWQAYYLSGQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5H7</accession>
    <name>A0A0N5C5H7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5H7"/>
    <dbReference type="WBParaSite" id="SPAL_0001320700.1">
        <property type="protein sequence ID" value="SPAL_0001320700.1"/>
        <property type="gene ID" value="SPAL_0001320700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001320700.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25515" checksum="54B453105804B51C" modified="2015-12-09" version="1">MPPKRNLRRGRNAGEISEIRQQLASIENQTNQVSEEITLASIYKLLQDIAHAQSILMSKVDALALEINKPKRIRAARGDEPLYSINTSNYERLKEDVEIDSNLKNFLNQHYDFDSINDVINSPGIFGRSVGTLLFNKEQFIAYKFTNKPVRNSPRKPYPPHYMEAFTAALNYVGLVCLTDDETKTSYMEDLYGDLNLYSSNVKLGKSKYPTNEYYFGDEPVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5R8</accession>
    <name>A0A0N5C5R8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5R8"/>
    <dbReference type="WBParaSite" id="SPAL_0001329500.1">
        <property type="protein sequence ID" value="SPAL_0001329500.1"/>
        <property type="gene ID" value="SPAL_0001329500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895455" evidence="7">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001329500.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="16063" checksum="953BD468E609C985" modified="2015-12-09" version="1">MVSPQFGCFRYTLVIVCLLTVFKLNSCKNSDDLHQIKEMAKNYIVERDVNNYLPEQYDIYRNFDVNSLEKRKNEFIRFGKRKNEFIRFGKRNNVNYENGVNDQISRIYPIYDFIDINDVHKANKRKNEFIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Z2</accession>
    <name>A0A0N5C5Z2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Z2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0001336800.1">
        <property type="protein sequence ID" value="SPAL_0001336800.1"/>
        <property type="gene ID" value="SPAL_0001336800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001336800.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12249" checksum="5544DC1F8FF8EE76" modified="2015-12-09" version="1">MGLISVLFTTETFAVGLNKPARTVLFTRLSKYDGASSRLISPEKYIQMAGTAGRKGMDTKGIVVLMVRKNIGTNALEKMVKGKSDCVNSAFCPTYSMILNFSRSFSVEELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6P5</accession>
    <name>A0A0N5C6P5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6P5"/>
    <dbReference type="WBParaSite" id="SPAL_0001361100.1">
        <property type="protein sequence ID" value="SPAL_0001361100.1"/>
        <property type="gene ID" value="SPAL_0001361100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001361100.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21681" checksum="E3F6A7EFCECC8CDD" modified="2015-12-09" version="1">MVNVGEFDQNDKKYFYLNVIHIKLAARFVVALQCIIIIINLIYSMTRTSTIMLYSWVISTFAIGLIGSLIYGVYKEKRHFVIPYLIYQLSSICLTILIFFVFTIGASLSHSMLSTLAYDFGAIDVNQPIDDLNKELHTFTIVTIILIAMAFIYQLFSFHVIYEFQKFLKNRESNFDFPATSEMDMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C749</accession>
    <name>A0A0N5C749_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C749"/>
    <dbReference type="WBParaSite" id="SPAL_0001376400.2">
        <property type="protein sequence ID" value="SPAL_0001376400.2"/>
        <property type="gene ID" value="SPAL_0001376400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18662">
        <property type="entry name" value="CD2_tandem_CHD3-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15531">
        <property type="entry name" value="PHD1_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000015">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012957">
        <property type="entry name" value="CHD_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009462">
        <property type="entry name" value="CHD_II_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012958">
        <property type="entry name" value="CHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009463">
        <property type="entry name" value="DUF1087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08074">
        <property type="entry name" value="CHDCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06461">
        <property type="entry name" value="CHDII_SANT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08073">
        <property type="entry name" value="CHDNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06465">
        <property type="entry name" value="DUF1087"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01146">
        <property type="entry name" value="DUF1086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01147">
        <property type="entry name" value="DUF1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="601"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="921"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1746"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1404"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <end position="1778"/>
        </location>
    </feature>
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            <begin position="1781"/>
            <end position="1798"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50013"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
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            <dbReference type="WBParaSite" id="SPAL_0001376400.2"/>
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    </evidence>
    <sequence length="1805" mass="207367" checksum="409BA8D8B248CD02" modified="2015-12-09" version="1">MSDEESELTLADDVSQDNSQLDGTEESQLPSEEEQNNSHAEEPQSKKKKPTSKSKKSKKSKPESIEEICEAYDMENPSLDYTEDDYVELTSYRHYQTKYREKIELFNPEADNSKQTAMVLAKFKEFKQLQSDFNTTKSNTSSSKKSSRSTGSKEKSVPALKIKIAGKKRGKKQESDDEFEELLKQHESELEAVEREKEERKIARAQKIAEKKAAQAAEANKFRKPKLENIEHKDYCEACGQGGEILLCDYCPRTYHLPCVDPSLTEAPEGDWMCPACEEECAYEERVSNNKQYCYVCKGGENLLYCTTCPFSFHGYCQDPPLEEVPVGDYICPRCKVEEPKNKIDKILSWKWEEKEYPEPYKKGELPPENTTDPTLKKKRKEMLYLRPAKKLDVKKTRLLYIKWKYLSHWHCDWLPEMVVEVHHPQTWRTYWRKNDPEVPPNFENDDDDEERTHRKNKAHDPLGLYDRFYKYGIKPNWLVVQRIINHISYGKNQYDYLVKWSELSYNDSTWERDDFDIPGYETAICKYWQHRHDMTGETIPKSVKKKIENKRIEDGITEDDSRKKKVVYDIRKKHEVQPDYITETGGTLHPYQLEGINWLRHCYSQNTHAILADEMGLGKTVQAMTFLYALYKENASKGPFLVAAPLSTLLNWEREAHTWCKDFYCVTYAGDKDSRAVIREHEFSFAEGAVKGGPKATRMKDPQSVKFHVLLTSYELINMDKAILSSIKWGALVVDEAHRLKNNQSLFFRNLREYDIGYRLLLTGTPLQNNLEELFHLLNFLCPDSFYDLEKFSSEFADVSKEDQIQKLHSMLGPHMLRRLKADVLTGMPTKSELIVPVDLAPMQRKWYKNILTKNFEALNVKNGGTAMSLTNVLMELKKCCNHPYLFAKASLEAPKCPNGLYELNALIKASGKLVVMHKMLRKLYDQGHRVLIFSQMTRMLDVLEDFCELEGYKFERIDGSITGQLRQEAIDRFNAPGAKQFIFLLSTRAGGLGINLATADTVIIYDSDWNPHNDTQAFSRAHRLGQKNTVLVYRFVTRNSVEEKVTSVAKKKMLLNHLVVRANTGSKGPSLSKSELDDVIRWGTEELFKEDDNLDENGEPKPIENAIVWDDDAIDKLLERKPFDPNEKVEKDWSDEYLSTFKVATYATKEVEEEEDETEVIKEEDQEPDPDYWEKLLRHHYEQDQESELQNLGKGKRVRRQVNYASNGANQEWQQVTIENDGEFSEDFSDLSDHSEGGDSDADGAAEARKRKKYGDDKLPPLIGRVNGLIEVLGFNPRQRKAFYNAVMRWGMPPSDAYQSQWLTRDLKSKSERVFKAYSSLFMRHLCEPVAESADTFSDGVPREGINRHHILARMGIMCLIRRKVQEFESYNGSWSMPEVKEQMDKAAAAAASNTGGGNSSETKEVTPLKEDKSMSPSNEDIDMADASNDGAGEVKTEIMDTESNENTTDNIMENNHAHASIDGIKRPRPPFKFNIADGGFTELHGLWQNEENSVSQGTEYEIWHRRHDYWLLAGITVHGYGRMGDIMSDPRFGILNEPFENLAKEKPNMNSQDVKSKFMQRRYKLLEQALIIEEQLRRAAYIEVEQADEDGLKNLDNHHSEFETLVHTHRELNERAKNGDRNSKIVMGKVLTRLEDLLNDMKNDLARLPGTVGKLSSVAERLHMTEREILSRLTTKDSTAVAGKSPLPPPGPFITPLIGQKLSSIQPKFAYLLKDVANTSKNETNTDNEKTTEKMDISVEEAPELQKELSNDGNQNNEETVQNEIVEKNNSTVENDLNDLKNEDVEAMDTSEKESQQSISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7K5</accession>
    <name>A0A0N5C7K5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7K5"/>
    <dbReference type="STRING" id="174720.A0A0N5C7K5"/>
    <dbReference type="WBParaSite" id="SPAL_0001391800.1">
        <property type="protein sequence ID" value="SPAL_0001391800.1"/>
        <property type="gene ID" value="SPAL_0001391800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001391800.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34568" checksum="DC83D26ABD587702" modified="2015-12-09" version="1">MFTKYGCFSKTLKHYNFLLYRNSSKKSENLLNLKEKHTLKYNSGKKDVGKKLTFGSIAMLIAPAFTFSLGCWQVKRWFWKKNLIDELENQMGKKRVEFPFDDLSKLDDMEYMKVEIEGKFIHEKEFLIYPRGRFDKGFKKSDNSSGIVASNNISSSGAHVITPFKIKDRNMIIMVNRGWVPKDRMPKDARLDTFPKEYVKLTAIVRKSENRPQFVSENLPDQGIWFYKDFEQMGKYCGALPIYIEATEEHSYLPNGPIAGQSNVEIRNKHVEYFLTWYSLTILTVVMWYMRFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7U4</accession>
    <name>A0A0N5C7U4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7U4"/>
    <dbReference type="WBParaSite" id="SPAL_0001400600.1">
        <property type="protein sequence ID" value="SPAL_0001400600.1"/>
        <property type="gene ID" value="SPAL_0001400600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001400600.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10065" checksum="3EE9E2F82B1F4F70" modified="2015-12-09" version="1">MYFTSFNRVAQIIILMCFISFAGINCEEYFQFLNQFKNAPLRAKRSQLSLNAGADVAEKLLKYREHQAKDSHKKHSPGKLGSGFDYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8W3</accession>
    <name>A0A0N5C8W3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8W3"/>
    <dbReference type="WBParaSite" id="SPAL_0001434710.1">
        <property type="protein sequence ID" value="SPAL_0001434710.1"/>
        <property type="gene ID" value="SPAL_0001434710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001434710.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41403" checksum="C604B4CDCFBC5799" modified="2015-12-09" version="1">MNKKLFFYFLLLLCLKCNITFLVLFPHKPALNLTKKQEEEFGFISSQTCLKFNKKTRRIRGAGINILKSSTVNKVSFPKHRNQPTNIYLKQSNFDDIRSLKYHVGLALGLIPELQRADRDKYVKIFWRNIKSKSKSYFKNKKQSPPSTTFDFGSIMLVGPKYGGVNGRITYKTKLYPYYDSLVYKTKVFSHYNFKTLSNTYCQNRCPKLECKNGGYPSSSRHCEKCICNYFFTGTNCENILTSRSKRCGNSQYYNASSTIQYLNSSRLQGPCYYWISSQNNRNIKITVERLYFDEVVTCTSDKGLFIYYRKDMGLTPLCIFKNVTKFTLPVVSSKIYIIFYGSGLYNSFNISYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C951</accession>
    <name>A0A0N5C951_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C951"/>
    <dbReference type="WBParaSite" id="SPAL_0001443400.1">
        <property type="protein sequence ID" value="SPAL_0001443400.1"/>
        <property type="gene ID" value="SPAL_0001443400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001443400.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19347" checksum="58720D66F69850A6" modified="2015-12-09" version="1">MVLAKGQSALRKVENEKEGSAPFKILSHIPECVAVQKRLEELKEQQKYLQSILSRGDNKIKIPKTPNEGGTGVSTVLLVKQDNSLRRADMKKRNIWKENAEKAKRGQEIKTKQVDEIRRSEEQKREEILREKKERELEEEETDTVWDRTIVDKSYGEIEIVYETPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9X0</accession>
    <name>A0A0N5C9X0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FIP-RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9X0"/>
    <dbReference type="STRING" id="174720.A0A0N5C9X0"/>
    <dbReference type="WBParaSite" id="SPAL_0001469700.1">
        <property type="protein sequence ID" value="SPAL_0001469700.1"/>
        <property type="gene ID" value="SPAL_0001469700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIP-RBD" evidence="1">
        <location>
            <begin position="323"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001469700.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43426" checksum="E161868192AB4A6D" modified="2015-12-09" version="1">MVEASEGNFIVHVVKAEGLVSKKSQQLNVVVVLKVTGKGSWKSEVSTDRLSITDGIANWNQSCEFNLQPDDTKLTIQVENYPKIDSSSVEILANMTFYLQELIGFEEPSWFTLKKKKNDVKERGRIMISFKFNKSLISAVSMCSLNSFGVKESRMDKLKKKMHFGRKKSKDTQSLASFSLSRRGSFSSICSDALAFGSDSPVPLAGGGDERYNSYSISRNPSLTQLQCINDSKLLSSNQNNQPHKQEKEYSITINNSSSNGGGFLKKNLFSSKGKNKSNMTFDDVYDKKEDLQHHKNHVPNNTNIYNLISSDKGCQSHDINSLNSSSDVTSQADITLSKEEMLSIIQELQRECSLKDEKITALRGYMEGLLTKIINTNPEILHVNGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA05</accession>
    <name>A0A0N5CA05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AXH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA05"/>
    <dbReference type="WBParaSite" id="SPAL_0001473000.1">
        <property type="protein sequence ID" value="SPAL_0001473000.1"/>
        <property type="gene ID" value="SPAL_0001473000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001473000.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43382" checksum="CD4C30A4F80C608D" modified="2015-12-09" version="1">MSIKVYSIEYFVLFFFVKHLTLLVNSSNNQGEFKHSEDIPTVPSTGQSKQSKSELPVKQVNRLEVINSLAMDSEAPVNSISEIPREQRAGWLRHGDRVIRFASVRPFEGTLSANTTPSNSLESEETRNYEYSDRINNFTHNHNSNNTNYYQNGPIYQEPNSDNRIPINFLPPPNIHPLPPIFGNGHLQHPFSTVSNAPLVPHTQYGHPQVFLGHINPPPVPPTHQIPYYLSQPNSVNFPRLVGYSCYPTVVDFAVTRRVLYPPLNHFVPHGGSQLNHNYHQPHHAQYEVSQSPGFASPPQDNVGPSVETNSNSDIIQITMDSQTNELNIFIDNRGEITNIQEQLRVPSADMVNEVDGGEENNVSNIPQNINISQENVPNRDMLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA54</accession>
    <name>A0A0N5CA54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA54"/>
    <dbReference type="WBParaSite" id="SPAL_0001477900.1">
        <property type="protein sequence ID" value="SPAL_0001477900.1"/>
        <property type="gene ID" value="SPAL_0001477900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895706" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001477900.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17052" checksum="910EA3E76572BAF1" modified="2015-12-09" version="1">MFLKIFTAFIVLSISKITIPKTYYNVHSDRLFNVRVSGTSKWDNPKVKDASVTLCGGQDLTVCASKNLNNNTDFLVAVFKSSSISLESFLVQFKYDLNGQKHYLTVKIPDACKNIPIHTKLDYTIYLNTTDFMCNLNDVYIDSLAKNFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAI7</accession>
    <name>A0A0N5CAI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAI7"/>
    <dbReference type="WBParaSite" id="SPAL_0001490900.1">
        <property type="protein sequence ID" value="SPAL_0001490900.1"/>
        <property type="gene ID" value="SPAL_0001490900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001490900.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="28007" checksum="F14B4219114A3F8C" modified="2015-12-09" version="1">MSLRIKFLIQLKFSIFVNILIIILSTSIFFHMFQIHEVTVSYYKFVELEEIDIYKLIHENYVITGSIFMFLYITGMILQLVIIVHLIYFYFTNSPETVMKNMVFHTFMSTVVVFIFTVWSFFAYFMARLDKQNGYDLEENIWSSEESRLMLNTFYIPGVMLFVQMVIRETAYSPLFKEYSKLISLQNEERKLKNIDFIKVTQMKNELFNDIFREKIQKNEDVEEDKIDDSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCM3</accession>
    <name>A0A0N5CCM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCM3"/>
    <dbReference type="WBParaSite" id="SPAL_0001562500.1">
        <property type="protein sequence ID" value="SPAL_0001562500.1"/>
        <property type="gene ID" value="SPAL_0001562500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001562500.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40038" checksum="DFD7868782CFF88B" modified="2015-12-09" version="1">MNGSTVCRTPTQPKGNSNIYENSNLPKSNNHSPWIQFPSNIVNLAVALKKSVISSSPSSGSSSSSSTTANNLTTNTNNTTSKGFRFKKANILKIKSANPLRYSTTQNETNIMKKIISDSRKRSQSLTTNFDNKPKLEIPTSTKEMPTNGRKDSSVHSGVLGQQAGGHLKPSSKESSSTTTPTTPTPTNNGRRNSTHGQILNPLAKSRIKHCLRNTPPKFGHLIMRRMCQQRPEIRNFIQNLSEECVNELSNSVAEFLFATVENIDDLPTIQKLATEFGESYVQYVYSGFRPEFFSQIADTYIAESLKLDGGGMHKRCEALLAWSQFMQLIFTNVRDGYYGKLRAQRRSSLPANKLYATKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCR9</accession>
    <name>A0A0N5CCR9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCR9"/>
    <dbReference type="WBParaSite" id="SPAL_0001566900.1">
        <property type="protein sequence ID" value="SPAL_0001566900.1"/>
        <property type="gene ID" value="SPAL_0001566900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001566900.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37262" checksum="E15F19CC0A516208" modified="2015-12-09" version="1">MFTYLDLIQMFYSLPSTLLLIIFAILLTNEMLIKKNPIFDNKFYPFILYKVYCDLLTELSTLFCDNAARYNIFGDFYKNNDPLAIYYFLVAGLTYTITFEISFIISLNRFIAVVYPLLMNYWFSKSRIKVWIFVTMVIGLFCGISFVYFNPYYNDLKFGSGFILAFRSKSTPYYSIYYTFLVIFPLAVASTVLNIITIKKITSEYRKSHNTTYNNKLNDLPFIVYSFLSFVCFLLFGLQNMIRAVNYLTINDEILNNFCDIAIRWTQDAQIFGLFYAILFLCKPLKNLILFRKKAAVAASSNAVQVTIVNRSKSRSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCV8</accession>
    <name>A0A0N5CCV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCV8"/>
    <dbReference type="WBParaSite" id="SPAL_0001570800.1">
        <property type="protein sequence ID" value="SPAL_0001570800.1"/>
        <property type="gene ID" value="SPAL_0001570800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001570800.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41172" checksum="66637F0936319283" modified="2015-12-09" version="1">MDPDCSAIDYSMEEECSKEQDYTPILSDDALLLILSELSWKDILNVKLLSRRFYGVIHRNNHRLERRGVVDLSIKYNGNCGEYPFFIKMGDTTVRNESSDVIQHDSYSKINRFKSCEELSSFLKMVDLRNIDKLNVPFADNHDIFGILNRSFQVGSNIGTLNILKLSEKDLKSFQTFIGKLSSVKKMFVEDICAHSTEMKDDFSLLSSLTSFNTIEYLDIFECHKTMILSADMAIDLLRRSQNIKFLVFGTGNIEFVRSVFKGFFKVEQPRKMEDECDYDEITLQIYFNGEYGLILDILRSSLSEVENVVEINNSNPEDVEFKSNVDCKYCFKNKHSISKYFLLCNTELSAYIGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDE0</accession>
    <name>A0A0N5CDE0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDE0"/>
    <dbReference type="STRING" id="174720.A0A0N5CDE0"/>
    <dbReference type="WBParaSite" id="SPAL_0001588600.1">
        <property type="protein sequence ID" value="SPAL_0001588600.1"/>
        <property type="gene ID" value="SPAL_0001588600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001588600.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="29492" checksum="633F24A517688A09" modified="2015-12-09" version="1">MEDKQLYIQREREADSLRSFAFAAVAISTVAVLISIFSVPMLYNHMQQMQTVMQNEVDFCRSRSGNIWKEVTRTQVLSKVTGGRFARQAGYGTSEGVEGSFAAQHTGGCCGCGVSPQGPPGLPGPDGQDGQDGAPGQPGRDGPDGPAATPAPAFDFCFDCPAGPPGPAGNPGPKGPSGNAGTPGAPGAPGNPGSDGAQGPPGPAGSDGAPGNAGAPGVPGVVEEVEGPEGPAGPAGAPGAPGEDGQPGAPGEAGQPGPQGPPGDAGSDGAPGAPGANGEPGPQGPQGDKGSCNHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDN8</accession>
    <name>A0A0N5CDN8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDN8"/>
    <dbReference type="STRING" id="174720.A0A0N5CDN8"/>
    <dbReference type="WBParaSite" id="SPAL_0001598200.1">
        <property type="protein sequence ID" value="SPAL_0001598200.1"/>
        <property type="gene ID" value="SPAL_0001598200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="67"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001598200.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25878" checksum="608E21A3C951732A" modified="2015-12-09" version="1">MIKKLSLKRSKHSSHRKVTVRRPSYNYGNCIMNIKLYLGERKIYKSIYYTIWRDFDYKHYWINSYADYKLRIIHHINLIRLIHGVCPLQEDEYLDALAQTYANELTKRGIFFRDSNNYSKKYGIIEGASLFSQLTAIVSRMYDEKNHYNFYLNFGTPMTSHFTQLVWKSTRSIGIGVLKKNDIFTIVLFFYPKGNIRGEYKKNVFKKQISWKKTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEE1</accession>
    <name>A0A0N5CEE1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromatin-remodeling complex ATPase chain Iswi</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEE1"/>
    <dbReference type="STRING" id="174720.A0A0N5CEE1"/>
    <dbReference type="WBParaSite" id="SPAL_0001623100.1">
        <property type="protein sequence ID" value="SPAL_0001623100.1"/>
        <property type="gene ID" value="SPAL_0001623100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="133"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="429"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="793"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001623100.1"/>
        </source>
    </evidence>
    <sequence length="990" mass="115003" checksum="18CEFCE6DFE1C9F7" modified="2015-12-09" version="1">MVVEDMDVTEPQNEAKNEKDDEDYIDPSENKAAKRVTSSGLNAIPSDSYKRFEELLRKTESFSKNLEVGTSSAPSKKATKVGDNRHRKTEKEEDEELLAAEEESKSVFMFTQSPPYIHGTLRDYQIRGVNWLINLQHNGINGILADEMGLGKTLQTISLLGYMKHFKKINGPFLVIVPKSTLQNWINEINRWCPTLKAVSLIGDESTRNTIIKEQILTNEFDIVATSYEMVLKTSSVLKKYVWQFIVIDEAHRIKNEKSKLSEMVRQLKSVNRLLITGTPLQNNLHELWALLNFLLPDLFSNSEDFDSWFTNESCLGNNEEIVKRLHKVLQPFLLRRLKSDVEKSLLPKKELKVYVGLSNMQREWYTKILMKELDIINGAGKVEKTRMMNILMHLRKCCNHPYLFDGAEPGPPYTTDKHLVDNSGKMVLLDKLLAKLKDQGSRVLIFSQMSRMLDLLEDYCWWRGYQYCRLDGQTSHEDRQRSIDEYNAPGSEKFIFMLTTRAGGLGINLTSADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITENTVDERIIEKAEMKLFLDNIVIQQGRLAEAQKTLGKDEMLSMIRHGADAVIASKDAQITDDDIDTILAKAEEKTEQLNNKIKQFGESSLRNMTFDTEEGKDDSKKFNVYSFEGEDYKEKQKQKSGLPEFWIEPPKRERKQCYELDKIFNDSKKTKKSNKPPRSKNQPDIKEFQFYPKRCYQLVEKENLYYRKSIDWKVPLPTNVSNPREALKKQKIEQKKIDNAKPLTKAEQAEKERLLQEGFPNWTKGEFLAFVKACEKYGRKDIRSIAQDIPSKTLKEVEEYSKTFWVKVHLLKDKDKILSNVKKGENRLKKTKGVQKAIDKAINDSVQPLEQLNLFSASHRQKLFLPEDDRFLLVQMSEIGWHNEAAAELICEKIRTIPRYRLDFRMLSRTPEDIKVRVNQLLSVMERNMNKKAEWIKFKDIAKQCEKHSEEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEH4</accession>
    <name>A0A0N5CEH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CD36 family</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEH4"/>
    <dbReference type="STRING" id="174720.A0A0N5CEH4"/>
    <dbReference type="WBParaSite" id="SPAL_0001626200.1">
        <property type="protein sequence ID" value="SPAL_0001626200.1"/>
        <property type="gene ID" value="SPAL_0001626200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001626200.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59194" checksum="994D5093F7E9BBF7" modified="2015-12-09" version="1">MISLNTSRIAVVIGVLLISTGVPLLYFVPNYIDNVFAKMDYLGKDENGTFNEMTRSWQKPVYDMSIQFYFYSVQNPEDIYKKKAKPILKEVGPYYFNEKQEKRNIKFLENNTKVQYENHRFYFFNKTLSCKSCSLSDRVLIPSVVFQKIAQFSDRFFLRNIIDIFLKTENISPFINVTVGEALFEGYKDPLLHLICSQPLMSQICDIFKIYEKVGFFYNKNGTSDGVYVVDTGVADRSKLSNIYGWNGMFGKLNDTYWYGEEARSIHDTDGQLHPPKLDSSKPIVIFAGQACRSITFDFLEKSNYRGVSSYVYSPMKSMLNMEEEQRKGFCDPKTPRYFNSTDTQIEGCHPNGLMDASVCIPNSPKVYISPPHFTSCPVEMRNKFVGISNDTNDDMTYIELEPDTGVIIHVESRSQINLGMVNKIFQITSKQDNLIFPIFYMKESIIMDSKTREQLMHGISFYSSIAIIIGIGCLFAACVVLTFGLWSYYKNKNSSESNSEYSNLVENERTENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEQ1</accession>
    <name>A0A0N5CEQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001633800.1">
        <property type="protein sequence ID" value="SPAL_0001633800.1"/>
        <property type="gene ID" value="SPAL_0001633800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001633800.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8928" checksum="04DB6685C328517C" modified="2015-12-09" version="1">MSSSDEEIAIGTTMDVFIKRSKYKSWSASEIIEKKEPETDESKEIRQNLDDIKKVLDEEKINDWLYTNFDSVMNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEW6</accession>
    <name>A0A0N5CEW6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEW6"/>
    <dbReference type="STRING" id="174720.A0A0N5CEW6"/>
    <dbReference type="WBParaSite" id="SPAL_0001640300.1">
        <property type="protein sequence ID" value="SPAL_0001640300.1"/>
        <property type="gene ID" value="SPAL_0001640300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="8">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001640300.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18624" checksum="C75E727C643313EC" modified="2015-12-09" version="1">MRIEKCSFCSSNVYPGHGITFVRNDSTIFRFCRSKCNKLFKKKKNPRKLRWTKTSRRLRGKELANDLVLAAETKRNEPLKYERAVWNDAVEKMKELAGIRTKRYVQLITNAQKPGKVVKKKGLIKKAQTKMHLIRAPVAEDQEVKQTQTSKRAVVEMETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF76</accession>
    <name>A0A0N5CF76_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 56</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF76"/>
    <dbReference type="STRING" id="174720.A0A0N5CF76"/>
    <dbReference type="WBParaSite" id="SPAL_0001651400.1">
        <property type="protein sequence ID" value="SPAL_0001651400.1"/>
        <property type="gene ID" value="SPAL_0001651400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001651400.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63847" checksum="571435B9B2477C54" modified="2015-12-09" version="1">MLLTRNKTSRLGKEGTPINNILENFNLEEFLLKRDYYGAISMLEYQLKLDPNNITTLSWLGHCAFHAGEYKKASKIYETILKHEKAPPGTEVYLGCAYFFMGMHNEAKEIAEKGEKSDLQNRLLFHVSHKLGEEKKLMFHHSKLKDTIEDQLCLASMHYLRMHYQEAIDIYKKIILSNKNFVALNIFLALCYYKLDYYDISLQVLQIYLQAHPDSVTAINLAAANKYRLHTPEAAQNEIRPILHLLNSEMFFGKDLLRHNNVVFKRGQGALQVLPSLMDTIPEARINIIIFHLKRDDVSAAYEIIKNLDPQVAQEYILKAITFTLVGYENKSSEHINEAVELFNLVGESQTECDTISGRQCMASARFLQQNFEEVLLYLNSIKTFFTEDIIFNFNYCQALIGNQDYKECEESIKYIRGDLMNSSTYQFCMIKCLINNGKINEANDYLRKVNKKSNYYEKILSLFGNECYRNGQYHAALSAFITLRNINKNSELTSAVRGCCIGIVKMYYEGKITKDELLNAHDILYNEEDVKSRHALNVIDKWAEENNIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFX4</accession>
    <name>A0A0N5CFX4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YqaE/Pmp3 family membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFX4"/>
    <dbReference type="STRING" id="174720.A0A0N5CFX4"/>
    <dbReference type="WBParaSite" id="SPAL_0001675450.1">
        <property type="protein sequence ID" value="SPAL_0001675450.1"/>
        <property type="gene ID" value="SPAL_0001675450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001675450.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6969" checksum="4F0B6546859E0C02" modified="2015-12-09" version="1">LDDGCVEIPLAVLLDDGCDAQFVINVLLTLLFYIPGLVHGFWVCFVREKPQTDVSTLKYNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFZ8</accession>
    <name>A0A0N5CFZ8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFZ8"/>
    <dbReference type="STRING" id="174720.A0A0N5CFZ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001677600.1">
        <property type="protein sequence ID" value="SPAL_0001677600.1"/>
        <property type="gene ID" value="SPAL_0001677600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001677600.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="82864" checksum="E6D50AEFF85C993E" modified="2015-12-09" version="1">MFNGINNSMSANQLSSLPFSFFNQSINGQSNRSNQLNFNISNGNPPQIMDLNNPNTSLSTVQMTHLNLLGNLQKFYMNQSNEHQNSIVENFKKLIGDNKWDPSLLNAIQCNSNVQPFNLLGNNSNLIFNNSLSSPFLNNNNPYDNTSKNKVETSSSTPVSHRRGHRSRGGTTQKTAKVWRFFDELTSSEEQAATCKICSKTIKATNSSTTGMIRHLRSCHHDEYQLLQEARLTSMLEKVGKLDDKNETIKSMFEDPSTAIVELQKQQQNDLKKNLIGNDSLIKLIAAKISAKNEPDSNKLIKKEDDDKLSSITENTTDDLGGSPDKLKPVNEIVDYTINSVDNVDIPLNLNLFPDLLKKDNDSKICLNQKRQRGSSTLYSSSTSNDTDEELFPEKRKYNKRCRKVGIFDESTKSCYMNDENITHSILLWCSMDDVEVEMLYRKGFTNFIKSAVPNYRLPELSQMKLLLRKINENNLFQSQFHKVNNLVQLPCIFNKDNDNIESSVMHSPTATVTSVGTTSSTISNNGIPLNENYDIQYTNLSDGSPAFNSNDEGSEKLQSPETDHDNLNNSVLINSVRNQYISNNFSHSIDLINERDQEKDGTDSESISSVDSDISNDDKIHQFLKSLDGEQNNTSNFNLLKSVLLITDFVKNNEEISSLITNDQTSTSINESINSKYTMNEIVKYLNILHSITFIVTHWEKLSLISQTNSFPFEFSNSNKEAIQQIYEQITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG07</accession>
    <name>A0A0N5CG07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG07"/>
    <dbReference type="WBParaSite" id="SPAL_0001678600.1">
        <property type="protein sequence ID" value="SPAL_0001678600.1"/>
        <property type="gene ID" value="SPAL_0001678600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF2">
        <property type="entry name" value="CLAUDIN-LIKE IN CAENORHABDITIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001678600.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="83365" checksum="DD341C59E18DD663" modified="2015-12-09" version="1">MVRRRIPLTIFFAVEVFGFVISLIALTSPSWQYVYLEDGRTEHHHGLWLDCKRDYSNDYGRTKEYYESLYRLADQGSPFDMFYLPQFMCVYKFDYYIDPEDLYEHNYDENKLQDDANQHLLLAWKAVALAAFLLSIVSSGVGLLIGICAFCHRTLTCASTVLVSIAGFFSIIGNLIFYIWANYQDNNVIKEEDGIYEQFIGWAFYASTIGTILHIFASSLGCLTTSFSFNKAKIVKIDIENSEDPLITISSQPTLDDRKNFKRTFSAVYKVDSSALRKFERECARSMRNKEIKMTQIMKNQQNKNNFIPYNLINPEMMMANKFNTSFKRANSVPNFKRYNNPLMSSNSIINNSSIVTEPILYKNNSHQSHQQLSSFQRRPSTVSLRKNFEQSNTKILLNKSVSFTNLNNYHDVSKRKSFTSEVSNNDSDTVYEYLPIQNKHRHLPNVRRQKMTSCNFIDKDNNEDVYSSIYAQEPFTSSILSNVEKIENEYLKPNGSSHQQSTVFGRECFIPSILKKDNLQKEVLINNRHTSAEFEVEKDNSSISSIKSISLPKNVIKLPMPPLPPKINENLVVEPINKQQQTKSILKVNSQKNISSTNIPSTSANKQLSSSTENNHLPQYILNKSSNKLFTGNNKTKTTTESTSPKIGQRFYKKRSSSRGHRTIVNSGVSTDLHNQKQSPTQSSEDCENECDRSIGSFTYLNNDHILSQRSSSININSDHTTSETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGM2</accession>
    <name>A0A0N5CGM2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rep_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGM2"/>
    <dbReference type="WBParaSite" id="SPAL_0001699800.1">
        <property type="protein sequence ID" value="SPAL_0001699800.1"/>
        <property type="gene ID" value="SPAL_0001699800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001699800.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18035" checksum="58243E15D82E47EE" modified="2015-12-09" version="1">MSFDVKPEFKLTHDFLQLLAEDRNFSLKPLVQILGSQLTDDPSSIRIHVSDGSSIYSHIYLMRRALEKFYYYKMDKHKSIIKILDYQYTKTSREGINKIGLTIYDFELIEKKSPIIGNPRNYLGNSEQRLALEVNKAGQIPLKRLRLSIPTGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHW9</accession>
    <name>A0A0N5CHW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHW9"/>
    <dbReference type="STRING" id="174720.A0A0N5CHW9"/>
    <dbReference type="WBParaSite" id="SPAL_0001743100.1">
        <property type="protein sequence ID" value="SPAL_0001743100.1"/>
        <property type="gene ID" value="SPAL_0001743100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF111">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001743100.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22570" checksum="E712E06534EF745B" modified="2015-12-09" version="1">MTPTSQIIDKKREGSTLRSRVTKSTHINEGKKIPEQVERRNERERKRVRQVNLGFVKLGEHVPKWRTKNKKLSKVETLREATRYIQYLETLLKSNESSTNKDTQSCIDENSLTYSSLSISSDNEYVIPPTSNNGQLQQSCFINYYDHQNSTNVSPTYSSSTPSPYYGGYTTINNQQSNNITAMYPAYIQQNASNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1W0</accession>
    <name>A0A0N5B1W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Programmed cell death protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1W0"/>
    <dbReference type="STRING" id="174720.A0A0N5B1W0"/>
    <dbReference type="WBParaSite" id="SPAL_0000006100.1">
        <property type="protein sequence ID" value="SPAL_0000006100.1"/>
        <property type="gene ID" value="SPAL_0000006100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="2">
        <location>
            <begin position="116"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="2">
        <location>
            <begin position="283"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000006100.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45967" checksum="A53EEFC7579DB5D7" modified="2015-12-09" version="1">MSYVLSRHTSECNDDPEILADIISTKESKKRQSLKEQQNLSKRNSRNSSSYSVDKGNAVQSPAKIRSRRSSRLSQSRYSSFEGDDNDDEDLIVNGVPDEDTDSDDNETYDIYNKAKAEQVISMTLIDYFSSQDVDETIEIILPYMNEKTMSETLEKIITYPIVSGDYGVSGAISDLIFGIVKKMELLNIEIYGVLQQVIEEILLAINEWSIVNPKAEDLIAVFLARLTLDDIYQDGHLQGLLGKFSLYDGADNCLNKAINIVNKPETISQIIPEVTGYEPIDDLSQQIYLIIKQYIRGDSIENTRKKLINLKTPLYKHEIVYQCSIISANENDKTVNILLGELIMKMYEDNELSPRFIKEGLFRFFQDVSNHQLKVGKDEVDGFFNVLRQKKELEIDECIKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B297</accession>
    <name>A0A0N5B297_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B297"/>
    <dbReference type="WBParaSite" id="SPAL_0000019900.1">
        <property type="protein sequence ID" value="SPAL_0000019900.1"/>
        <property type="gene ID" value="SPAL_0000019900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000019900.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="34142" checksum="2BCD77F0240254DA" modified="2015-12-09" version="1">MSLYHLLYYTIFIILFTKVDVLLGVDKKRVSFNDETEVKQFKSEDAPSKINKHEERVSWGSTNITIFDSNDPSSKVIHRVSRKGSRFRNTFRRKPTSPDHRVSMLNQYIEKFSLNGKIWHRVWDNCILHSCLMYNKYETLQKNFLTETNYYRKVHGSKPLILDTYLSSKALHVAIRSARIGRWIFNGKKSNAVNFETISFGLSPLLINKWYKEYRKYSYRKPVGTPESMHFSNLVWKDTKMVGIGIAQKGSDLFICFMFYPEGNQESKFKDNVHKPKYHLVNSRSFFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2N3</accession>
    <name>A0A0N5B2N3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2N3"/>
    <dbReference type="STRING" id="174720.A0A0N5B2N3"/>
    <dbReference type="WBParaSite" id="SPAL_0000033900.1">
        <property type="protein sequence ID" value="SPAL_0000033900.1"/>
        <property type="gene ID" value="SPAL_0000033900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19136">
        <property type="entry name" value="AKR_DrGR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000033900.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32291" checksum="70013457676A5781" modified="2015-12-09" version="1">MGYVHDKMPLMGFGTFQIKSSDIYQCLDVALQCGYRFIDTAQCYGNEKAIGDALQILLPKYNLGRNDIFITTKVAPNSQGKGKCRKSVLKSLEKLQTEYVDLVLIHWPGTANLSSDSVKNAKNRKESWEDLEELYNEGIVRSIGVSNYNIEHLKELMTYCKVKPEVNQCEYHPYFYTQDLVSYCKENGIHFQAYSSFGSAANKNVLMDDEEIKKFAKSRNVTVNQLLLAWSLSQDISVLPRSKCSDHIIENFHGSELKLTPSEVKALVKEEQRKFCWDPSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Y1</accession>
    <name>A0A0N5B3Y1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Y1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0000078300.1">
        <property type="protein sequence ID" value="SPAL_0000078300.1"/>
        <property type="gene ID" value="SPAL_0000078300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="152"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000078300.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40001" checksum="C5AECED5688DA174" modified="2015-12-09" version="1">MPISKFVHSLSRYILVPLALYISLPIIFKCSGKYAQKLIYLTQMHNVSNLKNPKQNGVIGRAENLYIRDKNGNRIGIYYIQAHSDSTTNKNNTSYITGTKIFKSDRPFVIYFHGSKGTRACGERINLYNILSQELDYNVLALDYSGFGDSEGEADIKNIINSSTALIDFVETTLKCNFIAWGHSLGGGILLETLADISSKYKYLLGIILESTFTSLNDSLYHHPYTLLYNWNTKIMETFIIRTLNKHGVVFNNKSNISKINVPILILHSVDDNKIPIQLGQQLYEEAIKKGKTVDMIMYEGNEKLGHSGIYRANSFKNDINNYINNCFFHHGKALNMKELLYNQNENINMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4E3</accession>
    <name>A0A0N5B4E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4E3"/>
    <dbReference type="STRING" id="174720.A0A0N5B4E3"/>
    <dbReference type="WBParaSite" id="SPAL_0000094500.1">
        <property type="protein sequence ID" value="SPAL_0000094500.1"/>
        <property type="gene ID" value="SPAL_0000094500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893726" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="617"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="912"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1087"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000094500.1"/>
        </source>
    </evidence>
    <sequence length="1202" mass="140266" checksum="D48C3A2DB3E89269" modified="2015-12-09" version="1">MLLKLYWLGAAVALMPLSIQPDPLYPQRFFSGIPKTIINTTFPFDLNTETTFDIVLVKCPFGEYKHNDENDIFKSESKIETSHIKELLYQDRTLIWTPTLRKSSSKVQLNCGKLIKDFVGSNDKYRFWTYNVMWKKTSTLPKSAEHKHTRHDLEEKHIKCNNGIDDALILTKNKENDIIVKVDPTNLKNPYVNQMFHYFNMPGENDTNLIQEPCATVKIYFNCPKITLKEYTSVIQKNINGTSFNVINTSGNQEIINVILDVGGDRSFYRGEKVLLKRMRYLKEETKVIEDSKISITSNFTIKGFDLVELAYNCPDKNNFKLKTQKYYFAPSIKDLKLEKKTISYSVNENLIKPNCPTAYLAIGYLEEVIYNEIRGNVSTLSSIDGIKDKFQKVGSNIIFDETENGTTTISCIYKTLDGHITTTTDFVNSDKVTERENYLKEKHLNDTIEYNKTLVLQQIALDEKNKKVKSINETLRETQKVMDQKIKETNKSFFQKFSDKVGERNAYVLTAGFILLILVILAVIFVILYKKWLGPFLVMLKYKKKYPNVYVFWDNLTSESFDTYCKTIRDKKYLSDKVLNRKVVKKMEGGEEVDIGISDLFDGTLVNCYKNMPMKIKAHYMYTDTENRKYILSDGITVDTQPSFWQMIYEEDIGTIVAIIYNKKTEDNDDASEDLYWKKDKAAFNDIVVTCSNTIKVNVLSVTGYKILLEKKGGPSKELELYHVSNWKENDIPQTDLQFVNVYQEIFKKAPKKNILIHSSQGTGARVYMLTYFACIYDALKSDKDIDCPFKVIKMMREQRYGGNLVPYEFAYLIKALVSTFFRNGILVDFSHRPFEFNISYDDFFYSYLKRKDKMDAELRKFLDFVNIVDKEKIYEYRSVFYMLGRMDSKTLLNYTKRFQSAVKNNIAGIDKRRFRYGDIPCLDAHGITVNGKPEADKDSFIHANKFEYTTVDKKTRKMILCQAPLDETVDDMLDMILRYKVTVVVVLVKPEEASDSQRKWVPYFPTQTHTLETANFSVLRMKIKELDKHFISETEYQLRSKKGLPEMNFTILHYQGWPDKSIPSEHMSIYALYKRVISLRTDDYVAIHCSAGIGRTGTLALIMYLIDTINYFPTFDPVERLKCLREHRYLAVQKYPQFVFALTVVFEHYKKQIDDMDADAYDKFLEVAENLYKKEKEIEDKVKKAMEEKRKKRDENKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B685</accession>
    <name>A0A0N5B685_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B685"/>
    <dbReference type="STRING" id="174720.A0A0N5B685"/>
    <dbReference type="WBParaSite" id="SPAL_0000157400.1">
        <property type="protein sequence ID" value="SPAL_0000157400.1"/>
        <property type="gene ID" value="SPAL_0000157400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF16">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000157400.1"/>
        </source>
    </evidence>
    <sequence length="835" mass="97683" checksum="A4E5B878C60FBCEB" modified="2015-12-09" version="1">MLKLLYKKNFPIFIQLLFYIIITIYLKNVCCQKAEDIINNNPLNVRKPNIILLITDDQDKELGSMDFMPKTLKILGNKGVEFLHGLVSTPICCPSRSSILTGKYVHNHNVMTNNQNCSGVEWRNIHEKKTFLNLLKKKGGYTTSYFGKYLNEYDGSYIPEGIDHFFGLIKNSRFYNYTLNINGKKVRFGDDYKKDYLTDNIINETIKFIDNHTKNQSNEPFLSVLAFPAPHGPEDSAPQYSSMFDGILSHRTSAWNYAPNPDKQWILQRTGKMEPIHVVFTDLLHRRRLQTLQSVDDGIERLIQKLRELNQLQNTFIIYTSDHGYHLGQFGLVKGKNMPFEFDIKVPFYVRGPGVSRNIKIDNIISNIDIAPTILNIAGVEEDKEMDGTSFLPLILKNNEKQKQNIVGKYNKNLTSNIVKENWRHTLLIERGKMPKLRKIKERFMKQKNAFNKELILDKACHLEEYQNSCLMGQKWKCIRNENLNKWVIIKCKDYIDVIDECFCGNKTIVENVREKRNSGKKNINMMNYQVSKIIHNWEIEFVKEHFLNNDSWYQGIIEIKRKRSIVTPIGNNLNNKSNNESSSNTIISKESIPSLAIDVLCLTVDSIYCESEFNLKLKKLKKKLSKIRSNKRKWKNMLKCNCSSFFQHNEYKNIDNNGPTILPDVYLSKYYVKDKSFLPLLKQFYPMGENLTEAKTKKGQFNSCNVPQMNCFTHDSTHWKTKPLWPENYGKFCFCQNTNNNTYWCLRTFNETHNFLYCEFITGFISYYDINKDPSQLSNTVYSLEINILEQLSTQLQLLKTCKGVNQCEHYSSKHWYLPYRNKKNKKGKVFKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7E5</accession>
    <name>A0A0N5B7E5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7E5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7E5"/>
    <dbReference type="WBParaSite" id="SPAL_0000197100.1">
        <property type="protein sequence ID" value="SPAL_0000197100.1"/>
        <property type="gene ID" value="SPAL_0000197100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="14"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000197100.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51898" checksum="EB120388DF1A6CC5" modified="2015-12-09" version="1">MSSDSMNKSEENKSLAILTIILTLDLIAFASILPLFPSIFEKYSVTNDNDLLLKYMNTSITLLQDFLHIPSDSRYNLVLYGGFLGFLYSLLQFFCFPLFGGLSDVYGRKPILIISIIGSLISYILWYFADSFTIFFLSRVVGGLTKASTSISIAIAADICDSKKKVKGIALIGIAFSVGFIIGPLIGAILSTATMNTRKDIPVAIFSVITSVIELVIVVIFLKETLIIRKQKINHIYQKVVLYVNPKSLFNYEAIVGSVSKEKHENIKNLSRSYFMYLFFYSGLEFTLSFLTHQKFSFTSSDQGKMYFYIGILMIILQGGILRRIPSERQLKTVLIAILIIIPSYVVIALSNNMVGFGIGLTMYSIASAFIVPCLTSMVAEMCSDSNKGTTMGVFRSLGALARAIGPIFTSSIFWLMGSTFCYCFIGILFIFPLIGLYQFNAAVTKNLEQQVIEEKSEMLKNKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7E6</accession>
    <name>A0A0N5B7E6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7E6"/>
    <dbReference type="STRING" id="174720.A0A0N5B7E6"/>
    <dbReference type="WBParaSite" id="SPAL_0000197200.1">
        <property type="protein sequence ID" value="SPAL_0000197200.1"/>
        <property type="gene ID" value="SPAL_0000197200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000197200.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="75417" checksum="A188ABF4F982C1E0" modified="2015-12-09" version="1">MNINHKTFLALCEEGNYEEVQKILNGRNKNNFFRFLRRIFKKSNGCNLSKIIDPKNEYTPLHYGVLGNNFNLVKILLENDPSLVYGSDVKGSYPISLAAYNGYYDIVELLLEKDVKMVNFANNAKDTPLHLASMNGHVKVVSLLLNRHCDTKIKNARQETALDVACKYGHVQVCQILIVHCPEFVIQSKVDSHSAEAGNNDIKNMYPLHICAQNGHNKCLNYLCESGFDVNHTLKEGTALHAAAVYGHINCIFILLKHGVDTKILNERGCDVIRELDNHINHHGTNITQVMENKEIWMEAKNIIESFNKGVSVAVLEMSQNMNNNNKIWMKVPHNSNVKGTENNNTVEFEEIVGKKPLVNFDQQFQNELKEKLEKRQAKANDLQEIYKQLSSVNKSNDSLLNKNETLSKHDQYKITLEKPPISPTSSLKSNGSGSKKSNVKTINKLSVDEKNINKQFTTPTEKITNHPIVKDISKITTTTIIKTKNNNDGGTKSYDNVPQAVVDAQQLINCHLKKDEKDNERRDETMISSTINKFPKTKEEVYELVNDIKKNEMIKMKMKEEEERKNLNSEENKIDGTLRYDNLGDVWKDIEVNKEKNIIIDDKKHNNTMSGEDINNCCKEISPKIRTLPCKKVTFEEIEKKDERKEEVATKGNDIIVSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M9</accession>
    <name>A0A0N5B7M9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7M9"/>
    <dbReference type="STRING" id="174720.A0A0N5B7M9"/>
    <dbReference type="WBParaSite" id="SPAL_0000205400.2">
        <property type="protein sequence ID" value="SPAL_0000205400.2"/>
        <property type="gene ID" value="SPAL_0000205400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF104">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="43"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000205400.2"/>
        </source>
    </evidence>
    <sequence length="647" mass="72784" checksum="E7463F1DA9B8DA96" modified="2015-12-09" version="1">MDKTSTSSNNNSLPLTKDLIKECSINSQTSSSTSSLSIKGVELTWSNIEVSVPYGKSRKTVLKGVSGIAKPGEMLAIMGASGAGKTTLLNLLTNIDQTKIKKSGSVRVNGKYLTVKEMRTISAYVQQVDVFAPRLTVFEQLTISAKLRMGRKCDQHKKEETVERLLRQMRLGDCKNTMIGSPTTQKGISIGEKKRLAIACELMDDPKILFCDEPTSGLDSYMAFQVVTAMEHQAKFNKTIVSTIHQPSSEVFYKFDKVCLMANGKVAYFGPVKELTKFWYSISTTLDCPPSYNPADFAIKMLSNSDDSDQSTVDARIQMITEAYEKSEYCQGILNKVIEINTQTAIDDESDKILTEYAASFWTQLQLMIWRGFKTLSREPMLFRTRIVQTLFTVSILVALYWNMELNASTIQNFQGLLYLTALQLNMFLFSTAFTLTSELPLAIREYKAGIYGLWPYYIGKSLSEVPQITLLGLIFSTALYWSTGLHREIYSFIKFASVNTITINTSLAFAHMAACIFFVEEHTMLFLCALGYPLVLFAGFYMRSPLIPLYMKPFEYLSFYQYAHTSIVANQWSNIGHIEGCIPSNETILPNSIQRHCQYSTGQEILESNGLTNSSYWYKTLSFIGLFLVFKIIGGVALNIRGRMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S6</accession>
    <name>A0A0N5B7S6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7S6"/>
    <dbReference type="WBParaSite" id="SPAL_0000210100.1">
        <property type="protein sequence ID" value="SPAL_0000210100.1"/>
        <property type="gene ID" value="SPAL_0000210100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893894" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000210100.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14864" checksum="B1EE1CDA08EB848C" modified="2015-12-09" version="1">MKVFKIIIIVFNIISFTKSHKLYTLDHFSANIQGTPECPPENFLDGEDVTMELKVPQYPGKSKSVTNICGNTLAVYEELRKETIERGGVFAEFTYKNSSKKVTKKVPDDCVSKHYDIFTYYCSFGVFEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8L4</accession>
    <name>A0A0N5B8L4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8L4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8L4"/>
    <dbReference type="WBParaSite" id="SPAL_0000238700.1">
        <property type="protein sequence ID" value="SPAL_0000238700.1"/>
        <property type="gene ID" value="SPAL_0000238700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="13">
        <location>
            <begin position="70"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000238700.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38896" checksum="B12AB3C3A11DD102" modified="2015-12-09" version="1">MGENIDSYLSGEPAPKKHMSSQAVLGLKKWELDNDVKIVDEKFICNVEEQKTLRDELKPWANDPKYFKKVEISALALLKMTMHAKRGGEIEVMGVMQGKVSGNTMIVIDAIPLPVEGTETRVNAQEQANEYLVSATDMSQYMERQECVIGWYHSHPGYGCWLSGIDVETQQLHQQFNEPYLAVVIDPLKTAIAGKVEIGAFRTLAQIDTSDNTSGVVVAKGITGDKAKDYGAHAHRYYELEVSFIKHKLDSEHLDILWQSNWNDILQKSSLTDCLMQTKGVVKNCLDEIRHTINNINDGSESNMSKVARKCKCVNNQLRHDIFLERLRLSIFNKNFNNLMGNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B951</accession>
    <name>A0A0N5B951_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hva1_TUDOR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B951"/>
    <dbReference type="WBParaSite" id="SPAL_0000256700.1">
        <property type="protein sequence ID" value="SPAL_0000256700.1"/>
        <property type="gene ID" value="SPAL_0000256700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000256700.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9435" checksum="D49331F186F09B5A" modified="2015-12-09" version="1">MSGRQGVRKSSRSPKPTNKMIQYKDSLKDGGNGVKRSVRDHDEGSIKDVVGGSMKNVGDRNAMNYVRSNVVDTGEKVNFETDNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAE1</accession>
    <name>A0A0N5BAE1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAE1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAE1"/>
    <dbReference type="WBParaSite" id="SPAL_0000301100.1">
        <property type="protein sequence ID" value="SPAL_0000301100.1"/>
        <property type="gene ID" value="SPAL_0000301100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000301100.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10118" checksum="7CF515D0B933FE37" modified="2015-12-09" version="1">MSLTTYSKGSIFPEAPGEGICCGSGCQNCVWLVYAEEVLRVIETHPDFSDKSNKKEIYRNIESQLKNEIQDPNLREFVLMDIRSKFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBD1</accession>
    <name>A0A0N5BBD1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBD1"/>
    <dbReference type="WBParaSite" id="SPAL_0000333900.1">
        <property type="protein sequence ID" value="SPAL_0000333900.1"/>
        <property type="gene ID" value="SPAL_0000333900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000333900.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="71855" checksum="30AC0CE4576DAC16" modified="2015-12-09" version="1">MGTSISRIVSSFKRQNEYSFSKRDMYFVKVLNEIEKKGDILVTDEIITHIEFVPSNWMDDEIFNRGKEAYKEYLEDYNLTDDTAFADNILVNQKPHDYVRLLFPDGNQIVKKSLLIKCSDFCSSKVNFSGRNFNEIIINTLSVETFRLFLKFLYGFGLTLTLNNCIDLYKLCDYLQVETVLSLRIFGYVKKNFVQLSKTKKFYKNFILINTDKYINDRFLGCFFKNLKDFNDVQRLVYLYHYINYPEIMTFQKEIPEVRYEKNFRCTPLKHEVYTFVLEPYKKTPKEDHLFKFNNVLFAAGVVSWEDEHWTVVREKDSYYVACHYYQLDGTVSFNKIPIKIRKNSKLKIIGYEDSIIALTNSFDILGNVDNSIHCRIFHTTTRKYQPSMDSAKLLSRFQENFNNYTDIKLDFNINLNHFYDFAIFAYKDYIYFLQENMAINVKHSFFRFNLKTGTKEDLNVPDNIRSSISQCIHNEKLYFLVTEPELFTSPWEDGEIRIDQVTSKYGYYFDFKTMKWYTYAQPKFALKHRNGFLKSQNGFLECYIIHKNFYKNIISVIQLHYNPDDQSQWTRVSTIQKPENLDIKIKKEHFLMWKESWDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBP2</accession>
    <name>A0A0N5BBP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBP2"/>
    <dbReference type="STRING" id="174720.A0A0N5BBP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000344800.1">
        <property type="protein sequence ID" value="SPAL_0000344800.1"/>
        <property type="gene ID" value="SPAL_0000344800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053352">
        <property type="entry name" value="FMRFamide_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000344800.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46046" checksum="72BB252AD57B99B6" modified="2015-12-09" version="1">MMSMNETSPDDGIINLLDDNTLPTTESLIAESVKSMEDAAWVHTGKLILSIICFVMCIIGVITNTFSIIIYTSANFRKRSINILLAGMSVSDLVVCLLAVPVFIGTEIPTLFPKIEVPPKILAYCIVYLYPITIMAGCMSVWMLVSITVDRYLAVCHPFMVRVYCTINRAKITVAVITIVTVAFNFVRFWEFDITEPSDETGGFAFKKLLRADPIFMLVYQNIAYIISQYLIPLFVLCLLNLEVAKTILKATEQRRELVTSVKTEHQTAKMMIFVVIVFIFCYTFGIFLNLLEHLYREIFETTIGYMLNDINNILVVFNSSSNFIFYVKYSTRYRAKLRELIGYCFLCSTNPKTIYSEGKSIGKTINNVGYSAVSQGNLVPSPKCYGKQKNTRMREDSLLDEQNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBR1</accession>
    <name>A0A0N5BBR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNAse P Rpr2/Rpp21/SNM1 subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBR1"/>
    <dbReference type="WBParaSite" id="SPAL_0000346700.1">
        <property type="protein sequence ID" value="SPAL_0000346700.1"/>
        <property type="gene ID" value="SPAL_0000346700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000346700.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21413" checksum="80D2BA3B51EE1246" modified="2015-12-09" version="1">MSSVFNEITIDESVDDARKKTLSFLRKLSNTKVLSPMLSSQVANKARNLSKNVFGTHKNSATKFHCERCNVILNSDMVKVNITKRNKKKLCEMTCKGCGSVFYFDFNARPKNGKCSEIKMEAKKDIKNTTLVLPKPQLVAKSKPRVNNVKPIVSNVKPKKKLTKLQMMLQQQAEADNSSNLSTFFDSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCG6</accession>
    <name>A0A0N5BCG6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein asunder</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell cycle regulator Mat89Bb</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Set apart in position or space protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13, IntS14 and IntS15. The core complex associates with protein phosphatase 2A subunits mts/PP2A and Pp2A-29B, to form the Integrator-PP2A (INTAC) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BCG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000371400.1">
        <property type="protein sequence ID" value="SPAL_0000371400.1"/>
        <property type="gene ID" value="SPAL_0000371400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000371400.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="89546" checksum="AFFF104C5248441B" modified="2015-12-09" version="1">MLLEFQRIIVDLYSSNEKYINIITTDTKVDEKNLAWKAENCIYRHFSKIIENIKVMEDVDEKYMEDSLYKNIDQCISLIGKITPSQKKFIELFYSNKNNLLDGKKNHRWWDLEFENILNDKNDRNFDFFNNLGMIILIVHNFNDEDVKNTFKHISSSFLEHKVNVHGCDRLKNIHLKIINVVDKEEPLFKKYCEEDLKSNIRLERYDIHLNENSKSTIGFVLREIFNLSSFTMTNIPMKDESNLKLNINVEMYHPKVDLPFLNIKKFQDNLSSIASCTAEYECVNMSSNIKLTKNLTTITAAWNSTPKRVPLLLQSLPFTVSDFSSREGSCANGFILGGKDIFPDILLKDSSVKGSELAFSLSKNIDNLKGQICIIDEALYESKSANEKGGQNLADKKIVDKMVNFIDSCTSNIEITDSPGLMIDNDLKNERIVNPLDGMMCSMESNDCFRSELNKITKILSRTDSIDSTYPYLKAIIESKERSNDEMKCILDVVSNFKYISKYHRNLYEGFCYYYFNKYITLGEKMKSRKFSSYKNIRNVTVKPTNKNVIERFLEFKEDNRPEFAGWCNNKNDVKLIVPLYQNLNKLELEEKQPYQSKYVAPDHDEDLLAEYSMHIQPLSDDYLKVAPPPYFGGCIIPAAFEKQRMEYRNYVNLLTNGSLSKEMKIEIERKCEKLRINYSEPLPPLVSSSVHQFDCRKRRLNGEFSSRTKKLYRYYIAPPRTVVNLTKQEAQLAEKLSKEYRESLKGKLIDVNAYKEKIREIEEMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD14</accession>
    <name>A0A0N5BD14_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD14"/>
    <dbReference type="WBParaSite" id="SPAL_0000390600.1">
        <property type="protein sequence ID" value="SPAL_0000390600.1"/>
        <property type="gene ID" value="SPAL_0000390600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF3">
        <property type="entry name" value="I-BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000390600.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="38162" checksum="6740766609E80789" modified="2015-12-09" version="1">MLYFLDNLYFEIREAKEKLSVHFLYTKPTDKYIVHDIYSFKEEVKFYFKIKNYSLTCGGTINKNVSMFDKAKQLNNYPINVARNFARQNSNSKYILIADMNHLFSKNFEKKMINLGKKFLSKKGKYALTYRIFEISKNITLLPERKGLLEEYIKEKKAFEFHHYMSAHKIPLLNDWLLYPEKDDDDTEYQFITNLSNSQWEPQFVSLTDIPYHDESFFYPVRDNTVLRWEMCYQKYQFVIAQDVFMFHQGIKSYDESISVKLAKDNIFPLAVKAMDNFEKRMIKRYSLDFNCPKPDKYGYGPGLKVRNYLNFQKIFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDA3</accession>
    <name>A0A0N5BDA3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDA3"/>
    <dbReference type="WBParaSite" id="SPAL_0000399200.1">
        <property type="protein sequence ID" value="SPAL_0000399200.1"/>
        <property type="gene ID" value="SPAL_0000399200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894388" evidence="2">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="203"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000399200.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39313" checksum="1355C931CF253293" modified="2015-12-09" version="1">MNQLLFTCYFLFLLAIKSICQTFNVKKIYLPGGGVKYQYNGRTYNSLEEITNEISGGNPNMKFVTQYSTNGQNNNGGYYPYQSKGNAINNVYNGYNSYSPNGRNPPNSFVGYKPYQPNGNTISNINNGGRPYQPSVNSIYNGYGNGVGNGPYGPTNQNNINNRFPPNPNSPNIYTSNGYSDQIWNLVWKGYDYRLDLQRGFSEFKKRALDEHNYYRKNHNVPSLSYDSTFLEPKAQAYAEYLAKSNTFKHDPNNGRLGTGENLAMASPSKIHHMVKAWYDESKKYDFTKNKYTPGLGHFTQIVWKSTVKVGCGLSSNNRAIYLVCKYSPPGNVGPSYNGYVFPPRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDC2</accession>
    <name>A0A0N5BDC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein DDB_G0290503</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDC2"/>
    <dbReference type="STRING" id="174720.A0A0N5BDC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000400800.1">
        <property type="protein sequence ID" value="SPAL_0000400800.1"/>
        <property type="gene ID" value="SPAL_0000400800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000400800.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57096" checksum="CD2F34ABED9DD1EE" modified="2015-12-09" version="1">MEHRTLRVRDNNAIMQKSMKGNGKQEPTQHEKNMKSLHDLVRTIESYPGKKKMSESEYNLPPPARIMPYSGIKPQDNAIIRPIAFRPIGTSEPGTVQKHFSITKTTPKIEVQGNQNHHTNMKVSPNSRDSYASAIQDNQITNIVKGNPPPYQSTFAPSRPKPINNSLTVSSYSNQKPQQNLYKEENDYDTVAEYVEKDKVCSDGSETYAYLPNNMKSSYHVSGNMTSSTHSSSMKSIGSRSPGSNVHLINQPQITPSPSDSGIVDYETLIKDKENELNNVRQTMEQNEEILIRVYQEKEKSYRHELGELKQKLRASQQGENALRCQLQKSEEEREHLNKLVTNLQNEKLTMNKKCSQIEKELYAMRSRIQDMAKEKLMSKSRMGKCDNCQMEIGAVNGSYNNSDGNEVYYNQSPPKPAPRLSKEVSSSDKELRNEVDALRSEISILREQLFEQFGIMNVKRDNSSSEVNGNNGGSRVKTISNNSFPNQINGNIKKPIISSDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF05</accession>
    <name>A0A0N5BF05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF05"/>
    <dbReference type="STRING" id="174720.A0A0N5BF05"/>
    <dbReference type="WBParaSite" id="SPAL_0000457500.1">
        <property type="protein sequence ID" value="SPAL_0000457500.1"/>
        <property type="gene ID" value="SPAL_0000457500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000457500.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26315" checksum="4AC8943B074F39FF" modified="2015-12-09" version="1">TRKLEYTDLNCNKLDDELSKTLNDKKKSIYRRYDNSIISKNLNFLEDKAELKKIFLIVNFFVFTIISLLLVVSIIIVEYILGNESFSPSEFLNSQKSGTGKNTVTFDDIKGISEAIADVMEIVEYLHEPEKYVRLGGRLPKGVLLVGPPGTGKTFLARAIAGEANVPFFYKTGSEFNEASAGEGVEKIRKLFRTAKRNAPCIIFIDEIDSICSEGVSKGLHPYANTTINQLIKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFD9</accession>
    <name>A0A0N5BFD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">14_3_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFD9"/>
    <dbReference type="SMR" id="A0A0N5BFD9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFD9"/>
    <dbReference type="WBParaSite" id="SPAL_0000470500.1">
        <property type="protein sequence ID" value="SPAL_0000470500.1"/>
        <property type="gene ID" value="SPAL_0000470500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000470500.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27933" checksum="0A5EEDED8947546C" modified="2015-12-09" version="1">MADNKEELVQRAKLAEQAERYDDMAKSMKKVTESGPELTNEERNLLSVAYKNVVGARRSSWRVISSIEQKSEGSEKKQQMAKEYRETVEKELKDICQDVLELLDKYLIPKAGNPESKVFYLKMKGDYYRYLAEVATGDERSSVVEKSQSAYQEAFDIAKEKMQPTHPIRLGLALNFSVFYYEILNAPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDAAPDDQDGLEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG52</accession>
    <name>A0A0N5BG52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RPL25</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG52"/>
    <dbReference type="STRING" id="174720.A0A0N5BG52"/>
    <dbReference type="WBParaSite" id="SPAL_0000496000.1">
        <property type="protein sequence ID" value="SPAL_0000496000.1"/>
        <property type="gene ID" value="SPAL_0000496000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000496000.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9235" checksum="37AD7C393D5C1BAE" modified="2015-12-09" version="1">MAQHKMKKKVSLPAGAKTKSGKVKKPQANKRGLMAAPKKPQAVADMKKAQPKLSLCYQSAKKNAKRRLKDNDRKLVYNKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG84</accession>
    <name>A0A0N5BG84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG84"/>
    <dbReference type="WBParaSite" id="SPAL_0000499200.1">
        <property type="protein sequence ID" value="SPAL_0000499200.1"/>
        <property type="gene ID" value="SPAL_0000499200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="187"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000499200.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="53493" checksum="BEE241F464CB9BA9" modified="2015-12-09" version="1">MDDCFLLNDIKSLKVSDVLRILEESFQRRLYSFKNVHPSISIGCLYCFDNLDNYLLKDVTNGCAFMSNIIRIEFFWKQEIINYLSVSIENSEESIHLEDILLKRVVVKVPRVDQASGHFDDTFQGDERVQMNSGSPESKQYMEMHIEFSTKKEILFYTNFSTNHSNLKIPKFYGYKMWDKINRDGLLIMEDLGRDPSINSDPNKVYGSVLPMVPGFNEQQLLSIIKSLAEIHGTSATIPMDEKIFATENFTVEGYMGWICSLYSLSEIAFVEKLNQKQFKDKIQRSAPFYCEKTLRDVYYGTEKRHGLQGIFVHNDFWAANVLFKKSPSGTFDEVHGIIDWQTLNLGNPMADLARLLAFNTTSKYRRENENRLIEYYHKIFNETVNDECYQVSLENLKLAYYESLPLILIFFAFSTPLYYFMNFIVTGTNEEIKKRREELINRTSDFYDDVLERFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGE1</accession>
    <name>A0A0N5BGE1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">H(+)-exporting diphosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGE1"/>
    <dbReference type="WBParaSite" id="SPAL_0000504800.1">
        <property type="protein sequence ID" value="SPAL_0000504800.1"/>
        <property type="gene ID" value="SPAL_0000504800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000504800.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="83748" checksum="EE44080F437B608A" modified="2015-12-09" version="1">MSLRSTFAIQIQICNLLLILCGLAAVGLAGSQFSKVRLDNYKEIDLRLLNWINILSGLVGIFCVTQNHGSILAKGLYIISLSFGIGTCIFYGFTTYRIVDEYNQIMKLQGTNGFTQEYSNDIDNYVGKIVISSIMIGVSFITCIVNLVAIIILDKLVIVDAPLWPPQTKSEEFDRKASKGALLIFAFIKIGIALPALGLCAFMEYERETLGVKNNYINIALDHITCILVIASAIVELFACFGKLQFMLNIKVSIGLSVLASVWCLKSTDMGMYPFYEDDLNRYRTYQNSPQNSVGTSSSPYYIIAACHGVLMGVFSIMFLLCVTSIILSCASIPMNLYNIRRKINKSLKIKSISLSIVYILLSCCLIALMVLGLVELPWNGIYIGGDLLCPLMLFLATGIFFSKYFKNFVTIRFVLSICSLCIAVEKTCATANLIYQSADRDIFIKGDKDIYVGQIVLYSVQAFILGLIALTSLLGSILYGRCIISIPDPSHDNKQGLSIFFSLGTLFYGVILTGCYVVFELGYWRYDARYLESPFFRMGNGPLAVGVFFVQFLCACNSKFLISTIILQTIVAGLASYTISWAITNTYYLQVIINATDILQNNPNTETIVEVGLILAAGAALACVIGMLCSAIIIMKSSFILHHGTQSSTNVDTDIIIVGTSQSSNHTSDVQRATPAVVRSKNDAKYYSSDDVNSRDDRRYYNQPYEIGNDGGTYNSQLNRETRLPGNVIYEEEIYREIACEKQRQNSSTQTDTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGK5</accession>
    <name>A0A0N5BGK5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGK5"/>
    <dbReference type="STRING" id="174720.A0A0N5BGK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000510800.1">
        <property type="protein sequence ID" value="SPAL_0000510800.1"/>
        <property type="gene ID" value="SPAL_0000510800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="10">
        <location>
            <begin position="162"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="644"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000510800.1"/>
        </source>
    </evidence>
    <sequence length="895" mass="103080" checksum="6CF1ADEF7FA9173D" modified="2015-12-09" version="1">MVIFTKHWGDSFAPAKSIPVDNVLKEMPKQIYSDYLDTTGKELKKYVKQKNNLEKQQQRIEEHHGKLNTGDIPKIFLDPDFNITRQKDFEQIFLIPDVDEVDVFQLDRNKSGSTTNGTQSNYSLSRKDSGSSIISEKSVFQYFNTTDLFDGRSFRSYGFLNSKLDYYHDLVGALLNEQLERKGEAFWKTVNSINSVHTELAEGKQKVATVRSNLGLINEKVYERAQRIVNLQQIKTNKQKLLKKLNNIACLKDAQITVQMLLNQNDYANALDCIEMSQDVLANDLKGVICFRHLSSQLNELEKAIAKMLQEEFVFLIQKEFGQPLKKDGDACYQESQLNQIIIGLLRVRFYKFLQLLKEEIQEAIKNLIRQTVKNHVVLCGKDLEEFDPSSTYNLTQQMKKMDFIQWFETLEDLFSTLVLFCKKILSIQEMIIDNVDRVRSMKLKQKEPYDNSPLQQSISLNSCDNEDEGVSTYEYISGQLSIPCNDLEQFENTSKLLLEYCSLCCQERIVKLLDGKAKNSFIEQCTSVQFDMLRKLILKFGDDCVNVISAGNDELKDETKEKVSSWSLTQCLQLQTSRFITFFHEQRRNKLDTLMMSEKWIPIKVPRSYQIFIDVSFRTGRLRLTEEMLSSEDTEDSFLFIEEEKYAVNGAVLGLLTMLAEYCTTLDMFPNTAAEMAMNVVQILKIFNSKTCQLLLGAGALTVAGLKTISVKNLALAIRCLQLIIKIIPLVEGEFEEHLTDINRNQLRHFAQTTKDLNDHIHEICTKITSVVEFNMLTSFQNWKIKPKLPSQEIQNVSRQLNKLHNAVTEIMPNEMVEVIFKHVHESFINSFKQMLLKHEVSSEDPLNFGLAEQEFEFYMLSIKAFPYSNEIPSMTISTLLNGFDIMGKEISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH58</accession>
    <name>A0A0N5BH58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH58"/>
    <dbReference type="STRING" id="174720.A0A0N5BH58"/>
    <dbReference type="WBParaSite" id="SPAL_0000530200.1">
        <property type="protein sequence ID" value="SPAL_0000530200.1"/>
        <property type="gene ID" value="SPAL_0000530200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000530200.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29040" checksum="8E084CD02687CD8B" modified="2015-12-09" version="1">MVNKCVGGTRNEVGTKYYKNLLDKAKEQDIDLYANDIDLLGEDNYTDPILRLIDSDLTRTLPSNKYFCSLNGEKIPKLRRILYAYRYYNTDIGYCQGLNRLAALGLLFLEEEDAFWFLVACINLQPKDYYNEKLLGVIIDQAVFSEIVNEKLPRLANHLKYLDVDFQLYSLKWFMTVFIDSLSHELYLKIFDCFLNEGNKVIFRFALALLKMCENDLLESKTFSDAHHILESIRNRNIQFSDLSNVSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHQ7</accession>
    <name>A0A0N5BHQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000549400.1">
        <property type="protein sequence ID" value="SPAL_0000549400.1"/>
        <property type="gene ID" value="SPAL_0000549400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="231"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000549400.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42908" checksum="AB4A1920CA3825E4" modified="2015-12-09" version="1">MYNLNSNYCVITITLSILFSQYHALEKNVKNDDSALLNFIQNDLSSKNFINQDSLIYSISESKYLRKRQADEKKGQKKSVVKKITKTKVPPKKPTHYRPTTKNPLVGKPQSSKPLPGKPPLNKPQTRKPSPGRPSRGPIRLTSRLVTRTPSKTTAKRSITLPKKTVTPPKRPTTTQTISKKLPPSKIVTSTQKTPTTVTTKPSSISAFTSTLASTSTSKPRPQIHLGKYTKEKLDLIEKINKERRLFQANDLTVDPELSKRAQKLTEESTEKERNVINPYKDVGMLTFYSNDDDHDYGFSQWISDFYDIKFDDPDNISHHHNNFTQIIWRGSKKIGCGINKDVNLDLSPITVVACLFSPKGNIPGNYSQNIRHIIYLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJH6</accession>
    <name>A0A0N5BJH6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJH6"/>
    <dbReference type="STRING" id="174720.A0A0N5BJH6"/>
    <dbReference type="WBParaSite" id="SPAL_0000610200.1">
        <property type="protein sequence ID" value="SPAL_0000610200.1"/>
        <property type="gene ID" value="SPAL_0000610200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000610200.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23510" checksum="923B6A88681436A5" modified="2015-12-09" version="1">MSSEVFSMSCFPNDDDYQGSLSALFAQGSLISMTSRTGEVLEGILLAYHLDYQIMAIYIPETNEKNPQLKIVNMHHFNDVKILKAPQSGFKLPFPTTSTSEERNSRMAAAIKKREQQFMKEEISREGQEAFLVLQQTIDKIRWDKKDIVVLDCVRIVEPYTPECVQLLSGDEESSVSNKRSLEYVTNCLKTKNSILERILSSSNKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJS8</accession>
    <name>A0A0N5BJS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000619700.1">
        <property type="protein sequence ID" value="SPAL_0000619700.1"/>
        <property type="gene ID" value="SPAL_0000619700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000619700.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37853" checksum="046A49212A1D65DB" modified="2015-12-09" version="1">MSNLFFILTLFLNITINILTIVLCTISLIIIYKKWNKNDLSRRYIEITGVQFALGLISGVVNIIAKQEVIVDGSYIIWNFDYFNIFGKGVNILLIYIVTTVAYINTAMPVVVLISRNWIIIKNKSLETQSQHLIILLAVVILAVLVVSFTTVLCFSMHDEGNAMSKISENDTFAITFLSPEGFSPICRITSVKFIVCSTSTVLFFNINCIVFTVHYRNYKKYMNQFQQNMTEKTRKMNIEFARILYLQSLTPVLITGVPIIIFTAAIFLRVEVIVFSGVTYLVLLVCFVPAMNAIFFIILPLGNRKIIQTTIKKIFSNKIASGDKSLNNQTTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK33</accession>
    <name>A0A0N5BK33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CULT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK33"/>
    <dbReference type="STRING" id="174720.A0A0N5BK33"/>
    <dbReference type="WBParaSite" id="SPAL_0000629800.1">
        <property type="protein sequence ID" value="SPAL_0000629800.1"/>
        <property type="gene ID" value="SPAL_0000629800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000007">
        <property type="entry name" value="Protein cereblon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULT" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000629800.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18190" checksum="093E138A6DEE0B18" modified="2015-12-09" version="1">MKYILVFRIIFCLLWLIIINTVRTYGNNLLCRSCGSLITNDRAIIHKNSPLNSGEYIQNVVGVNATIQKFINPANEEFDVMIVNGATLMYHGDPSFEATWYPNYQWTICLCRKCRKHMGWYFSKPRQEKDGFIGLILDRLISEAYVDQMILPPGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKB0</accession>
    <name>A0A0N5BKB0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKB0"/>
    <dbReference type="STRING" id="174720.A0A0N5BKB0"/>
    <dbReference type="WBParaSite" id="SPAL_0000637000.1">
        <property type="protein sequence ID" value="SPAL_0000637000.1"/>
        <property type="gene ID" value="SPAL_0000637000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000637000.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38702" checksum="42F17FA86D185F5D" modified="2015-12-09" version="1">MPAIPHLKKNRTLNCDFCQFRVLRLLGQGGFGAVYLVEEVNTKGKYAVKTELIPGKHDKFQPRLLWEETILLEIQALQDENQKKHFIKIVDRGTFPPLRYMLMTLVGKSLYDLQVQQKNRRFSDNTCWRIAEQTLEALEAFHNAGFVHRDIKPQNYTIGGEGREDIIYLLDFGLVRCYTGKQFTHGLIDRPNFAGTIKYCSRSAHLSVFQYPKDDFESWVISIMNFHNQGSIFWSRETDLIEIKHMKMDLFAGKEPYRIFRKLVPSDYKSLVRMVGDLTPPHLIKKPNDIMRGKVPFTPFYEKLKEIQKNCRFSNDKPFDWQKKKISKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKV1</accession>
    <name>A0A0N5BKV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000655600.1">
        <property type="protein sequence ID" value="SPAL_0000655600.1"/>
        <property type="gene ID" value="SPAL_0000655600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000655600.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20967" checksum="3D1D3BBE76B3EC4F" modified="2015-12-09" version="1">MESTKDYGDQYLTLTDRSSYSSVFETELTPSCEEYFYNSGMICNNPIITETTASLYSTLNDDSNYSNCNTAAPFSDDDFELVEKIKNESVPQRLHICLYEKSQYFLNKNEVGMNIKEPIEEPQSLYCFGNNYYCGMTKNEPKKFVNSQYQSNDLINYNLMKEGQENTYQFSGVESQYVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL89</accession>
    <name>A0A0N5BL89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL89"/>
    <dbReference type="STRING" id="174720.A0A0N5BL89"/>
    <dbReference type="WBParaSite" id="SPAL_0000668900.1">
        <property type="protein sequence ID" value="SPAL_0000668900.1"/>
        <property type="gene ID" value="SPAL_0000668900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF0">
        <property type="entry name" value="DISCO-RELATED, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000668900.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53744" checksum="F19BC9B16C529C38" modified="2015-12-09" version="1">MGGTNPFTAENLAKPDTKKIMTNQSLGNFNIPSLQNELNTMQRFGLDFNHASTLIEQFKNSFMPSIFQNCNLNNSNNTNNLNIINQTIESFKKQDNDGASVGTSISNKSETINHSKNTDTHPLVSSLPNTPNMLMDVKNNTSFQISSTIKNDTSKVKSPINDEIKGELNKILSNRLIPSSREGRGSSYGKSSKKRVQCLQCLKTFCDKGALKIHTSAVHLKEMHKCTVNGCAMMFSSRRSRNRHSANPNPKLHINTAIHPRSVMQMVTPRLSIPKNLSTNDCKKNKSHKLLNITSPMDTSTTPSLLNIPSTDLFLQTHLNNNNSNKNNNCLKQQDKILTPEASPKENKPDLHHHHQQPPNTCNNGGIFGNINNIFLPTTNFLNFKHSMDVSLNHPQGGILSHQSINPLSTIIPPTTTPNTTNNIFTNLQKAEELRKVLAGNNQMTDDGSINKATTMERRENLVDLMRRLQYTSLHTEIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLA7</accession>
    <name>A0A0N5BLA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Rho guanine nucleotide exchange factor 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BLA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000670600.1">
        <property type="protein sequence ID" value="SPAL_0000670600.1"/>
        <property type="gene ID" value="SPAL_0000670600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="105"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="13">
        <location>
            <begin position="870"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000670600.1"/>
        </source>
    </evidence>
    <sequence length="1454" mass="164530" checksum="2D67C1B5D8A64A3C" modified="2015-12-09" version="1">MTLILRSEDIYCLYGSCFSEFNEKQFHFFIIKITSIIPPVITSKPVIVHNSVNKANTDINKHYKTQTSLAESAYSSLESPLGRSTNIVTDNQNNFHENVSLIQRCVVIYADCNGYGITVTKTHPVTVENIEKNGASQKAGVKKGDIIFKVNGIQITSTNCSSVINMIYENCNVVLTLLSKPFDNSELLYENNQKNLEKQKIEDLKKEKITTINQMLQDEKINVEKLKASSPNNKTPLKRALKRIEVLQLQLKKLDNQIFNDQIDDYETIADDSSFILSQKNPLKHSNFYETHRLDMNTSKGHDGYSISKESDNFSMPSSLNLSTHGPFSNLPELKSRPAHLAIFINYLLQCADPSCLLFCLITDVYQTAPVTYKELRKWAYEIFSTFLIPNAPLSMPSIDQNIIQNIDKVLGRPYSSSEDYLEELHIVFIPSKRKALEHVNLDLVAFRHKQQLGLGDIFEPKILEQLDKNGSGMEDRIAEQMLLKTLESQYNIINGELEKAKPKNVAIICSLATVIKNYFGMKPNSAHFEKLLEKCPTFVTKDKSGGVFKMKSISQKRIVNIKGHPFILQPVNITVFCYQCQEAVWGVNPQAYFCQNCDVVIHKFCSQNLVDHCYPASQQKKNQQGKKKATSSLLGNKTNNSDLLQNTPTNTQYNSSDYGISMKNVISLHDINNTRYQPISTSSSGPSNNASSLGGFTTTGMLPPNVMERTAAYIKATAAYSAAAINKPPAGSIVVDETIYNKSTFSDSDLISTGSTWITNSDLKGKSVSRSQSLHCNKSLDTKSRVSTGKSDGQQILPCLNELSQMDITENDNSPNEKYANTISNGDEAEIFVDSGDNDSDLDVTVEIPSLENILSTETIRHLKPKERKRQEVLNEFFYTEKTHLRNLKVLYKVFYCPLLTKKWCSSYEIEILFGQLEELLDIHREIVKKFENRMEIWRQKPDYNGLYGDISDLVLSIFKGSDGERLKLTAAEYCKNQQYALNFLRKKQAKGKEDLLAKFLMIAENNSLCRKLQLKDMLPMEMQRLVKYPLLLEGVAKYTPDPSPEYDGLLNAINAAKKIVSYVNTAKEASENERKLMEINSRIDISYKSSQNEIIKSFDITKHKLIHDGSLQWKIAKNKIIDMHVVLLHGYLICLTKSSDGNKLYLKSHEPSKDVRLHPIMFLNNLMIREKANDKRAFFALYKTNDSQQMFDVLAPTVSELKTWFRFLGEQIEIIQKDNLNDPTLRLNDINSDIKNRLLLSTSDEMNGSDSDKVQVVTHPRLVDANEIMIQQPTVFEHAEPILTPEEKLKRNDRIIIGALCEKHQILCSLISSISKEQLIQLSEQLAGLSVVDLKQKDSKELALSAIVHGNRLLDSINKGMSVRRSNDNESTYQIDDYEKHLPSVPCYKLTTIAAPLMNHLKALLQTIQDQQNEIVELKKQLNTTIGHLVMKGLPLDDTPPAVPNTLPPEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLB4</accession>
    <name>A0A0N5BLB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">A4_EXTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLB4"/>
    <dbReference type="STRING" id="174720.A0A0N5BLB4"/>
    <dbReference type="WBParaSite" id="SPAL_0000671300.1">
        <property type="protein sequence ID" value="SPAL_0000671300.1"/>
        <property type="gene ID" value="SPAL_0000671300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019543">
        <property type="entry name" value="APP_amyloid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF15">
        <property type="entry name" value="AMYLOID-BETA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10515">
        <property type="entry name" value="APP_amyloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894481" evidence="12">
        <location>
            <begin position="19"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="13">
        <location>
            <begin position="38"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="14">
        <location>
            <begin position="253"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="8">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="8">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000671300.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="85584" checksum="150A15E87E33B2C5" modified="2015-12-09" version="1">MLPGSIFIFLLQIIFSFASPKDGIYASIDTPIPTKLHSKFIPMVAFLCGYRNKFSNENGGWTTDTNKFATCLTGKLDILKYCRKVYPNLNITNIVEYSHEETIDKWCREDTPNCKFSHTVRPYKCIDGEFVAQALQVPNGCMFGHMSSRSMCSDYSQLNNKAFNECIKMKDNNGKSMVLRSFSVLQPCAIDLFRGVEYVCCPTIIKNKSNEFLTNDINEITEGNDFDDDVFGSDDLLNIIENDDNGTLLDKGEQDPYFKEITNANNEHEKFREAEKRLEQRHRSEVSRIINVWSELYDKYKNMKDNDTNEAEKYKKDMVRKFRKTVANIEEENKEMKKEIETVHEERLKNIFNERKRKATHEFREALARHVEKDNKIEVLRTLKACIRSEEKDRYHMLNRYRHLLRTDAVEAEKYKTELLHNLKYIDLRINGTIAMLDDFPQLAEAIGPIVKSFWREYRKEHTPEIESDVLSNAIGENDNVKLVNLYKTHYEKLHEAEKNIRKKYFSKGNIKKATTTPKPTTTTTTSTIPPATEINKNSIYNELEKADLEKGDNDKSNEVNDIEYVKFNKNQTDDRSDYDEDEDDNDDDDSDTSEEGNNNKKQETFNDSEEDNVPVEIEPIISGPIMDSTFDENPSYVKLSKMDHNRQLYSYNKSQSYLSSNFIIYGFIGTLCCVFFVAAITLYSKNRHSGFVEVDVCTPEERHVNSMQINGYENPTYTYFDANAPVKSQNEESLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM42</accession>
    <name>A0A0N5BM42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurofilament heavy polypeptide-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM42"/>
    <dbReference type="STRING" id="174720.A0A0N5BM42"/>
    <dbReference type="WBParaSite" id="SPAL_0000698500.1">
        <property type="protein sequence ID" value="SPAL_0000698500.1"/>
        <property type="gene ID" value="SPAL_0000698500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000698500.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="62100" checksum="D630B822E89CA4BE" modified="2015-12-09" version="1">MANGDLKFYFSKSKSRSKHRRSITAAEESRDVGTGREIDVIPKLDENQGETRDVGTAREIKLMSKIEAHQDETQDVGTGREIKTMVKADAHQEETQDVGTAKEIRPNRKAVLADISNGPTSDVDTAKEISQTAVLAPKDSSKAQDATSQNPTPPVVEELPKVAPPTETPQVVPPASEVQQTTNVVVSETPAAKQLAQESPQAVTSSVPDNSQALQKSEPAKPLEVEKQKSEETGLQKDVTPAVHIVPSDVSDIKKDEKVKENQVDKPEESKDNKPEQSNEVKPEPVKENVPPKAEEPKAEKQEESKVSNQEAPKENSTPKVEEQKVEKQETPKEVVAPKVEEPKVEKQEEPKVSNQEAPKEVVTPKVEEPKVEKQEEPKVQNQEAPKEVVPPKVEEPKVEKQEEPKVLNNEAPKEVVPPKVEEPKVEKQEEPKVLNNEAPKEVVPPKVEESKGEKQEGPKVLNNETPKEVVAPKVEEPKVEKKEETKVLKQETPKEVVPPKVEERPALKTESPKPKLLSGEIKKNSAVSETNQTPKSNTTKSQTKVEEPKAQPAKSSFGCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMI3</accession>
    <name>A0A0N5BMI3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMI3"/>
    <dbReference type="WBParaSite" id="SPAL_0000712125.1">
        <property type="protein sequence ID" value="SPAL_0000712125.1"/>
        <property type="gene ID" value="SPAL_0000712125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000712125.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14136" checksum="725957A045A96A2E" modified="2015-12-09" version="1">MKRYELKTLLTVQYSFQDSSSSSSSFSSSEESQEEDGLPRKPTVSSRFHPLTSILSRAELIKELEGRIREGKERDDKLIEEAMEALDNYRFVIDESRINNEENNKLSSENSVSYNKNILFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMI6</accession>
    <name>A0A0N5BMI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMI6"/>
    <dbReference type="STRING" id="174720.A0A0N5BMI6"/>
    <dbReference type="WBParaSite" id="SPAL_0000712333.1">
        <property type="protein sequence ID" value="SPAL_0000712333.1"/>
        <property type="gene ID" value="SPAL_0000712333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000712333.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22675" checksum="5F1D1632291CA910" modified="2015-12-09" version="1">MRYAPTRQTIKNIVKRFNKHGSVGDVHRRGRPLRKNAQQLCMARSTLHNVIKHKIKFFSYKSQDAQELLPVDKNQRKEYATKIKELVEKDCNFIDKLIMDDETNFYLNEKSEGKKGYSMMWYIIKKKFGPYFFEDKKDDSVTINSQRYCDMLENFVAFELESFPKDTWFQQYGASSHTAARTIKLFKKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNV8</accession>
    <name>A0A0N5BNV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000758600.1">
        <property type="protein sequence ID" value="SPAL_0000758600.1"/>
        <property type="gene ID" value="SPAL_0000758600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000758600.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21269" checksum="0714CD2BBA25646E" modified="2015-12-09" version="1">MMEPSNNELLNKESYNDQSIYLTLNESIHVYLALYPLLSYYLFISTSLPILSITITVASVVESTTGTFSQKNITIFESFNFSDNLINLIPLNILLFLTSLIYLYKFNILHRCIDYCDIAKINNFDQTHNLKPSNYSGASELEKIPILINENTEDTPMGIRKENNFTIVEEYSSDEDCFDNRKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPF4</accession>
    <name>A0A0N5BPF4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPF4"/>
    <dbReference type="STRING" id="174720.A0A0N5BPF4"/>
    <dbReference type="WBParaSite" id="SPAL_0000777900.1">
        <property type="protein sequence ID" value="SPAL_0000777900.1"/>
        <property type="gene ID" value="SPAL_0000777900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000070">
        <property type="entry name" value="Putative carboxypeptidase suro-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF51">
        <property type="entry name" value="CARBOXYPEPTIDASE SURO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894655" description="Zinc carboxypeptidase A 1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="171"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000777900.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="85260" checksum="46F8E53FC643BDB6" modified="2015-12-09" version="1">MIKYLWVILPYFLYINGSFFVDNISNDNKEIFSVYRVTPRKKEELDVLRKLEANNSRNGLDFWVEPRRINYFCDIMTHPTNQEDLISTLQRHNISYRLMIKDVQELIIRNERQKRSKNKGSKKYNDKKIKINIGNHSNFFKRYEDDVIDSHHRAKKLENIGELLAKYPFGEYTSYSAMIKYMRTVEFYYPNIAKLIRIGKSHEDRPLEGLKIGIDSNNDKTKKRAFWIDGNIHAREWASSHTALFIINQLVAGYGKDKFITHFLKYYDVYVMPMLNPDGYEYSRSSTHPEVRLWRKNRSPRKCAPGYWGGIKCCMGTDLNRNFDFYWSETGSSDNPCSNQFHGSSPLSEPEARAVSDFLTSDEMFDRLDGFITLHTYAQLWIHPYSHEYENYPTDVRDISRVALKAINRLRAIYGTDYNYGTGADLLSPASGGSDDWAKSALQVKYVYLIELRPEMELSGGFILDKDELIPTGVETLEAIKVVMEACLAKNKIPTKPDDLVLEDVKTRQNVFGAFFGKDTNIGMFSNINSQTTPSPFGVEKMLVSRATTTTTTVKPITIENVIKTTKKIVIKDELPSTTTLSTTTKHHQITMKKDSMSTPGIPITKNNNILTEKLFRKQILRLQAEGKLSDVLKTNILYQSKDLETSNHQEEFEEIEVPKEVKITSPLNIKSQILSKTKLLPLQPVYHNHDFEKKYEVCEDNQRSCKLWIKARPNVCQDHKRFMEIQCPLSCSYCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPS6</accession>
    <name>A0A0N5BPS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ricin B-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="SPAL_0000790200.2">
        <property type="protein sequence ID" value="SPAL_0000790200.2"/>
        <property type="gene ID" value="SPAL_0000790200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="5">
        <location>
            <begin position="1967"/>
            <end position="2486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000790200.2"/>
        </source>
    </evidence>
    <sequence length="3170" mass="364061" checksum="92EF0DECC3266816" modified="2015-12-09" version="1">MLEGLLALVLNRYVGEYLDDINTDNLSIALLSGQVELENVPLKKSALSKLELPLSLKSGVVGKLTLTIPITSLRSEPWIVKLSDVLILLEPSFNVYEEEYLEKCEMERKEKLLLELEELHKKAILKKINYSTPDDSEQNQWWGASMITSIINNIHLIVDNVHIRYEDDQTLEVPFNSGIRIQNITVNTANSQWKTGFVNSENENFSFKKLNIKGVSIYWNGHDQVISDITCINQLRDLLLPQNYRDNCNVIKSFGLQMRMSKNLSKLPLFHEDTPRFKIDIRPTKLDVEMTTLQLHQFRALSKEWARIDRAKNFRKWRPSVSIKDNPKVWWKFAILCVKEPISKVINRNTITYAYNRAKLVNQYVIAYKKRLVYFLKNKITEMPDGNKILLENLTIFENIEGDTEKASDTAFIKQIERGNEISYYELSILRDVLAKKIMNEIDKDMKKIPLENIIKEEKDDEFEELEVKRKSSNVVEDSNSTSSNIYGWLTSWISGTSKNGEILEDDDKKFFDKEEDFSSIKSHTLPPNLKKLEQQVEQDLFDALNETWDDTAVFTRDKVLANFTLQIDRIILRLINENKMNDIPASRCLTMDMSKVSSKVIFSARERRTNILLTAGNFNIQCTKVTSLFSENTISEVDHLSSASFEDDLDKQNTDLFYSNEVDDSALGLFGETTTADVAQVMFAIGRSNHDIRYGCQNETNSPILTMSYSRFAPKSTVFHNLNAELKPISVTYDESAIDDLYSMFGIKEDDGIGGKEFIETDEPKRDEFKIRENNFYCHFKIPIVEIELKTKRKNLFNDEGEADVGESFATLIMDGVNVGLAKTEQFVTKYKFSVQKLCLRDMYDNKFAKLLEIQKNNKLGLSKTISKSYQTLNSINVVGKKHLSLNDLRVVGYDNEKTSEKVIGKNKYFNKKIFGHISSDFEMSETDQLLLSITYVNKKHPQFSTKYKETEINVDGQMSDVIVGMNRRSWILIQDFIGLIPRPQKGKFNFDKQDIELFTQFLSQSGMEFEETVKITGKYLSNCKNLPKSSSNMEINLFMDTVKIFMNYPRANTYLGSVDVDDVNLSLKIDRNNDKKPMLMDIGLSKLLVNSNTCSYSCLYPNVISIYNTEKDDKKRGIRISIEKNRTSDPHLEKPYDMKLTMDVDKSYRFVYLHTQRFLISFSDFWTNLMDLQEQITKKRIINIDEVDECKLKGRILLKINADCETFTILPLNQFSTECIILESTNLSLSNRFQLASETTFYDENVIEKNAMQDGTDCLLDNMEILLSNLKIYKGRRITNESRKNCVSIISFNESEIGVLSKSILNKDYDLRVLFSRNLSNFISRNVPNMSAVLFFNDIDITFTTDFYKLLRGFLDKNLGDSIIQNPDTIPLECLLRPAQDIDAEQLKSFINFSFRIQFNNVNLHMLTPTKEFNDYENLGTLIFSDVLLSFDSYVENQSELNLVCHSIFLKDSRDSYSNEKSNVFKDTLLPKYDNCKDKSVIAEIHMLMKKDEAPKVTFVLQKVRLLCIIDWYINIKDFILLNTDFVPPTDEEMSISQEFNSLFNSQEMPINKSVSVMVHERKHTISLKLQLTDTDFIFFEDISDSKSLSLILSFTGSLYLDDVNGLLNVKLEVMKTQLSWSIFTSERDTICLISTPMKFSVEIGCETSKLTLTEKVASIITGMHLEEKLPKHVCSCYIEESSFRLSYKDALIVNSVLTGTIENFKKSLNHVHWKPPPNDNPTAFNSTKIKRVQVNISKFSFWFLDDFKGPAVSVMRISASNTVIEKIHNDFNCKGSLSMEYYNSKLGNWEQFLDTVVIDSLAIHQPKNQKKVIDIKINKDSPLDFNITTPLIHLCNTLSKKLPYMIKAIDENFKIWCRKGRTNQVSYSIKNDTGSDIAFTYQIDKIHSKDNVSQKSVKWFHVGVGKNVSFTLPISRSHLYDTINTNQNKLAIFIDGYEELPIISLESIKIFTVYGKRKNNPKFKNSGYKTKVIISITMDNDGRKSISIRSAFSIINYLTVPFMLRLDNTDYGEIEWQKVRIEPQSEYYVPLNYVNARIYGRPLLSDSEILPNKITEYIIIDLKDEYFYKLYQKAILKKFKHDDDKISYTCISSKQDDKVYLYKNIPGQIITIFSPFIIRNQLPTDVQCLVNGKTYSCKSSKTISMVDVNINENIEIKFMTDKLVSTNSIKINKGSIKKENDEKSLIVNMEDEQGRQLDIYTNIFLAKSGSIVIVIWVTYWIVNKSGIPLIIKKRGSSSDVAGQLPEHEYGKDKNPLMLSFKDDEEIKKCKVRIGNKFAPNREYTSEYSNSFKLTPGEHSLTLFLKHPNEPTLIYNIGVEINQGRGRYKNTQVIIFTPRYLLINRSSHKIHVTHSDDIHSKNKVILDPTSNVIWNESFEDNKMICVRRDDVKYWSQPFKINQVDSFHVNMRAYDETPNFVRVEITLNNARFCITFTDTDLYPPPIQIVNDSHIPVLYHQQIETSIPSHLRSICKAHSKIDYSWDCLYDKKLLTLQASTFKSNTYDLSKPSFGPPLIYENYSYIFLKSTIQCNDNNFKNIASMKGHVLTVAENNRVRLVSINKNLPDSTQLWNITDEGYIENVSLKIIENNIPVSYVLDVNKEGESYGLIVNKKDLSRKKTQLWKFDKDGRIQCGIAGYCLKRKDRNYLRLEKYCETSSVDDDSLFIHIFQKEGDGILNVVSNYEGPTFVVRISDYNSSKNTDTSSNTKKEPLYDINFYIPKGIGVSLINNSFEELIYGRFCGVYLNVTVKNNSYEGTLNVKSIQIDNQLEEAQQFHFIYCDSPDDRLRDDFYIPNNQEDASVLYYSSLPALKVELNWTPKEHYDSFECLRILFSNININLDELLLWKFFEFIKESVNDDNILSDNFNQPPSTDLDCVDIRSARRCYFGSLHLKVGNVSLSINTIPFNGMPKKLKKIKSNFNIQLISFENAIISLPPFKQEHTFETLSFLAESLSKFYISELKTQTFKIIVSLDAFGNPLGLATDIKESFQALVFEGDLTGFVSGFGYGVANSFSKVVATVANGIGTLTYDENHELLRRKAIKSSNEPNQNNPLTHIYSGFKGLGVGVIGGITAIASNTAKETQKEGIIVGSVKGIGTGVVDTFTKPIQGVFDFIGGTALAMKEIAGSGYMKKSNIPSVRLRPQGYYQQFQNSRQKSRLLIYNNNPGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPW5</accession>
    <name>A0A0N5BPW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tachykinin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPW5"/>
    <dbReference type="WBParaSite" id="SPAL_0000794000.1">
        <property type="protein sequence ID" value="SPAL_0000794000.1"/>
        <property type="gene ID" value="SPAL_0000794000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000794000.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28731" checksum="A46AD888C30FD8B3" modified="2015-12-09" version="1">MSVSFLIIYILGKIYQNHYENLRNNNKNEMQFYDISKLDNDFGKPILFDDKIDRGLLDYSNDAISSNKDTPTHSYFDDLKRLLEIDNFVRKNLISKKYSYYGKRSHIPGRYIGLGKRSIVNSDEIKKRYRKSGDVEKKFSDNNFRSIGLGKRSLKNGNFKKYEDDVQVNSLKKNYIMFGEKTKEGIPVVQKYGIKYIPTSLRRRIGEKKLKSKNKSANISNTFFKHDKDINSINILIKYMNVRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPX8</accession>
    <name>A0A0N5BPX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB2 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPX8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPX8"/>
    <dbReference type="WBParaSite" id="SPAL_0000795400.1">
        <property type="protein sequence ID" value="SPAL_0000795400.1"/>
        <property type="gene ID" value="SPAL_0000795400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026627">
        <property type="entry name" value="NDUFB2_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15223:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15223">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14813">
        <property type="entry name" value="NADH_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000795400.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18617" checksum="3B8EE12034F1EF97" modified="2015-12-09" version="1">MVLGRGLANLVFHTKTFTPQQKKIILTTIRSKWLSAKEAERIAGVPVGTRMGSQQDPERNTFDGHYNGTPGKDKPLHDFYYRQAIPHTTHLDKTLSRMISGFLWFWFIYHMYYHSGVLFGHWYMPYLTEFSDEELGIPPDNAPDPEYWGNHDKKYGTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQJ9</accession>
    <name>A0A0N5BQJ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQJ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BQJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000816300.1">
        <property type="protein sequence ID" value="SPAL_0000816300.1"/>
        <property type="gene ID" value="SPAL_0000816300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="282"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000816300.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35148" checksum="241C3A3CED09793D" modified="2015-12-09" version="1">MGNRKIIKERLKKKKKRSFSNMSKVHSTEGQDNEKFKIKKYSLNLLHKLSDTFRLPKKKKSSLEDGDESSESSANLSVTQQKEDKSSMQNVSFNESVISRKNSMSNTKNEPNNRSNSISEMYLVGNESEYKRQMKNYINNLASCSNENLSLHKWLSMVAKIFILLEKYFTSINTANIFNFDSAFLKLFPVDVIQSIVHKVISIISEEPILLELSTTPKDIVVVSDIHGSILDLIKVLMDNGFPDSKNYLFLGNYVDKGTEDVVVITLLFLLKICYPKTVYLLRGNHEFLDHIMFIEYSIMVLSFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR12</accession>
    <name>A0A0N5BR12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR12"/>
    <dbReference type="STRING" id="174720.A0A0N5BR12"/>
    <dbReference type="WBParaSite" id="SPAL_0000831800.1">
        <property type="protein sequence ID" value="SPAL_0000831800.1"/>
        <property type="gene ID" value="SPAL_0000831800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="389"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000831800.1"/>
        </source>
    </evidence>
    <sequence length="771" mass="89743" checksum="94484B3E74E7AC2D" modified="2015-12-09" version="1">MVKVKKKVSKVGKEKTKTLKKSENVSNLLINHKQGTKWYENTFDDKAKSEDDLLSGDALKKIEEKANDLWKKDCNNFNKRNNISSTTINWMETVLSKGTFSDKITAMQLCIKKSPVHSIDHLNGLVYICEKKKLRNLFMSFKLLRDMFLDDLLPPDRKLVSFSMRPLAKINEISKGNETVANKMLVMWKFESELKDIYYKFLKSVDSCSTVAVENIATQSSSLLMDFLMARSERESEILSMIINQLGNPHRKNASYIIVLLKKLIEKHPSMKEVVIKEVELLLFRKNIPIKTQQYAVGFLTQIFLNVVEKNVAQQLLKIYFCLIKTLLAKENTECKLMDLVIVGVYRVLPFAKDKINEMSKEIESLYKLISVAKYSISMRILRLVFKSSSIMGTVSDQFYSALYRFMLRDHPSKYQKDLCALVYDAVKHDLIFERQRAFIKRLFQIALVGLPELAAEALYTVGRLVKINKKLVSFSEENSLYEFKKDEVEDEIIEEEEMDDEEVYYDYDVDEKGNVIKIKADIDQTTVQKSKLSMKIENDGGKDLKITKYYSPFGTHPQYSKAHLTNDIELTYLKKHYHPVVSDFASKLISGKEIFYNDDFKEDLSIIRFLDRFAFQKSKKNSKGSIKCLAVDSEEYITAKPSKIPVDEAYIHRYACMKYEKSKKNDDDEDRYSINSDEFDDIIKNFNDQIVTEEFNEEDEYDDDDFDVFEKELEEKQQVGKKRKRTSDAEKSLYQILNDIDTEEADDSEEEVGFDDDDDDFEDDDDENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR52</accession>
    <name>A0A0N5BR52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR52"/>
    <dbReference type="WBParaSite" id="SPAL_0000835600.1">
        <property type="protein sequence ID" value="SPAL_0000835600.1"/>
        <property type="gene ID" value="SPAL_0000835600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000835600.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16630" checksum="69824568EB38B77E" modified="2015-12-09" version="1">MNVSKILTVFIIISTSCIVIFCRRGYILAVNGKPGCIIWGPIKREENVTTTLANNKTKNILLSVTNLCGKPIKISKFLPADIIKSNDLYVNFAYNISKKFFTKIIPKDCDANGVINRDYFICDFVTAKELAFRKLCDQLVGTVGWCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRK8</accession>
    <name>A0A0N5BRK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000850500.1">
        <property type="protein sequence ID" value="SPAL_0000850500.1"/>
        <property type="gene ID" value="SPAL_0000850500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894773" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000850500.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24037" checksum="ED4804BBD2D11812" modified="2015-12-09" version="1">MNLNKPIHIFLIIIFAVFVNAVDSYEWDSDRQAAARFLTERIFGAVINYNVSNALMLANNINKFKKKKTGKYNKSIFRKNKWSGISKKILKNTDKYEKTKDLEMKHSGKIYDNIKYTINKKSKSFGNFKSTSFVDQNMIQKPERVSSERFVINHSNSPRGKLIKVEASPFIRELPFEDHDLDIVAPHLAGIKTLIVDEPLELRKTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS47</accession>
    <name>A0A0N5BS47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS47"/>
    <dbReference type="WBParaSite" id="SPAL_0000869300.1">
        <property type="protein sequence ID" value="SPAL_0000869300.1"/>
        <property type="gene ID" value="SPAL_0000869300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000869300.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18835" checksum="D4281044C45A7B36" modified="2015-12-09" version="1">MVVIGAVFLCFVTEINQYRRLHDVPPLKVDHGLNKLAKKHAWGTCLNDPSMFKSSSKIKYLGLRYHLVHGNIIVKNMYEKFMLGYNWYAKHHVGRYDKYAQLIWKGTKKVGVGVCVRNDNIDVVIAFSPKISTRDFNANVRPIGLKHVHMFGVFARNSETSRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS51</accession>
    <name>A0A0N5BS51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS51"/>
    <dbReference type="WBParaSite" id="SPAL_0000869700.1">
        <property type="protein sequence ID" value="SPAL_0000869700.1"/>
        <property type="gene ID" value="SPAL_0000869700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="123"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000869700.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32740" checksum="943416064DA63A04" modified="2015-12-09" version="1">MTGEFRNLFSLCSRTPKPSQEKDYQVAYYLYNYKVLYECNGFFFNQHKYVVEYYSKLLSGKDRNKRPKGAMDCKYINPYKPSYLITVYKNRDILKSNPFCDKIYERVWLGCDYDCFAANNFRLLKQGYVVEINEYRRLHDATPLIVDPFLNKLANEQANESCLKKPSLFRKYPHIGYLGGVFPVKHANLIITKMYDKFLTSYNWHAKRHEGKYDKNAQILWKSTKRVGVGVCVKYNQIYVTFLFSPRGCTKHFHNNVRPISPKHIHMFAVFGRNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT28</accession>
    <name>A0A0N5BT28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000902100.1">
        <property type="protein sequence ID" value="SPAL_0000902100.1"/>
        <property type="gene ID" value="SPAL_0000902100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000902100.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16694" checksum="30F37B400721E039" modified="2015-12-09" version="1">XRLRQARQNRLRQQRLRQAAQRRRMRQQAAARRRRQQLRKRQLAMRKRIEQLRRRLSSTVRMTTTTRTTVRPTTASPESYDEGETTDGEYEYGEQEGDQNNGESEGQTDGDNQDQENVTEEGEDENTGETEEPQKEEQATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUI6</accession>
    <name>A0A0N5BUI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RabBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUI6"/>
    <dbReference type="WBParaSite" id="SPAL_0000950600.1">
        <property type="protein sequence ID" value="SPAL_0000950600.1"/>
        <property type="gene ID" value="SPAL_0000950600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000950600.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="74859" checksum="49B336B6F3529F9F" modified="2015-12-09" version="1">MSKGDGNGKELGEMNCEEENKLVDVITADYEIKGIAFKKLRDAETKYREMERKLIIMKEEREKELGTNKYCSLCSNKFRIFDRIKICKNCKCQICKNCIDDNMICEYCETKDIFLIKRKEFRTLCPYSNTEFGIYKFLCKLETWRQRAKLEVHMMRLLGDTFENCPIFIQIDDPPLNECFKRLHKEISDYAFSNELSYINSAYRDFYRQLNRLWLTIPTKMTSKNRFVMNLVPVIKQKEESYPATKYFSAVAHAVAYKCEVILRQKLEKEHVKNVKLNILSHIQSIPRFRNFNSYKNSPLYENTNRYFKKSDQCNTLSKIPLSKIASHKMSMIDLSSSTNTGILSPVTRCSSVYLEKQHDLFGKDKEQEVIEVCNGNSCMPLTPNSTKMSTVKKYIQDDSNIVKITMDRNKIKCQSGRMVLVTCKVHCPKDTLLKKDDILWLSAKNKVIQIGGKNQFSIDGNNLQSNGYYELKLSLFDVNDSFNGSLGICALVNDKMYFNCCTLSVKEEPFDTTEDCKFPKGIKISKKDDGVIVVEVQPEGYPTPYIEFLQNNKIVEEDSNHKITVKNGTWVLEISNMIQAISTDSQFSHSTSSNINSALSSFEIVAIARNRFGTATAKGILSNGDKKETQKNVVEYDSSLETVSISSSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVI9</accession>
    <name>A0A0N5BVI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000984600.1">
        <property type="protein sequence ID" value="SPAL_0000984600.1"/>
        <property type="gene ID" value="SPAL_0000984600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000984600.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18044" checksum="2ABEE34108C65772" modified="2015-12-09" version="1">MVFRLLSQASVNKTCLGFVCSTIFSILAKKFQFDFDCLDKKQREFRNIELLPSSRDETMPKLKDRVILIIEEQIYPSSVVTMGYNIGHTCRIVFYLNTHGNELLIPCMRKTMHKVTGYMTFAKPYCDENEFCYETDVTIDIPYEDNDDISCADFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVK3</accession>
    <name>A0A0N5BVK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVK3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVK3"/>
    <dbReference type="WBParaSite" id="SPAL_0000985900.1">
        <property type="protein sequence ID" value="SPAL_0000985900.1"/>
        <property type="gene ID" value="SPAL_0000985900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013334521" evidence="1">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000985900.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19929" checksum="62CAC26E12806253" modified="2015-12-09" version="1">MYFCIAFIFVLGVNGVSIVKVNVKPKIEEQDNFNKNKLKEIPDVGEKNITKAIFDLKNDKENQDIEKTIQNLLFHNKVILFSKTYCIFSKRAKEVLSKYDLKEFEVVEIDTIENGHKYLKALKKFSGIQTVPQLFIGGEFVGDARKIISKDNSGTLKEILQGANVLFDKLKHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA9</accession>
    <name>A0A0N5BWA9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L15, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001010900.1">
        <property type="protein sequence ID" value="SPAL_0001010900.1"/>
        <property type="gene ID" value="SPAL_0001010900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010900.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34323" checksum="9426D4145DCF2675" modified="2015-12-09" version="1">MTSSSIKNATERALKYVSSASRIKLQDLRDNPGARVTGRQLKKAHNQLGHTIGELQRAAKPPLGWVWGDFFRPWHRIFPGERHFNGDINLRREYPPISLIELQRLIDLNWIDTNKLIDITTLCNTKRISIDPNQRQFGVQLNNEGGEIFAAKVNLEVQWASEYTIAMIEKNGGTIRTAYYDLNSLECAVDPKKWFLSGKPIPPRKAPPQSLMLYYTNPRNRGYLADPAEIEKDRIELAKKYGYTLPETTGKATEVKKPTEVFLGIESGSIVSLKDKKVFVPTDSTLKKYYTDEYLADWQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWF8</accession>
    <name>A0A0N5BWF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BWF8"/>
    <dbReference type="WBParaSite" id="SPAL_0001015300.1">
        <property type="protein sequence ID" value="SPAL_0001015300.1"/>
        <property type="gene ID" value="SPAL_0001015300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF9">
        <property type="entry name" value="PROTEIN CBG14864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001015300.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33335" checksum="2644ED47A0F9EF09" modified="2015-12-09" version="1">MNLKIVLYVLVVNSLSAIVRKKNQFPFNALLVLPSKESEFDHFRLTINKALPVIDIAIDDAVEQGYVPKGFLNVTTHDSRYWQDISLAERYAVQGVVQAYTEKRLDVIFGFADFYSLATVAKVSPALGDGVPVLTTAGMISQLGSKKIYPYLIRMQGSITQMADSVYQLVAYQDTTTRTIENMDVSVIKNTTIPSISTNLGYKNLFFIYNDKKRAVNKKLHLYKDGSGDSGETEISSYCYFSLYAIKSYFTSKNQHFKDVWKMSAPSLAFDEDNNVSQTDLKNWLKLGSTYANGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWN0</accession>
    <name>A0A0N5BWN0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="5">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with RSC1A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWN0"/>
    <dbReference type="STRING" id="174720.A0A0N5BWN0"/>
    <dbReference type="WBParaSite" id="SPAL_0001022300.1">
        <property type="protein sequence ID" value="SPAL_0001022300.1"/>
        <property type="gene ID" value="SPAL_0001022300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000007">
        <property type="entry name" value="YrdC N6-threonylcarbamoyltransferase domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="14"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001022300.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25256" checksum="540F559320F04479" modified="2015-12-09" version="1">MKRFISIDTDQNYKKAIELASKILKNNGVIAIPTDTIYGICSSLYNSHKIYDIKGRDQYKPLGIFLPNIESIDNVAIVPDSLKLLVNKLLPGPVTLLFKRSPLLPISFNPGVDTIGIRIPESRFVQDLVKHFGEPIAQTSANKSGATVNSTSINHFSDIWENLSLIVDGDNLFPQNKSTICHPGSTIIDLTKFGYFSIVRDGVIKEKVQKILIDFGLNEINAENGTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYN6</accession>
    <name>A0A0N5BYN6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYN6"/>
    <dbReference type="WBParaSite" id="SPAL_0001088700.1">
        <property type="protein sequence ID" value="SPAL_0001088700.1"/>
        <property type="gene ID" value="SPAL_0001088700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001088700.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32303" checksum="0C1B823228377E39" modified="2015-12-09" version="1">QIMTNASFFLVNSNPLLDIPTPKSPKMIDIGGIGIPKPEPVSENFNEILNKRNKTILISFGSIAKSTYMDQEMKDEILKTIQNFPDITFIWKYETPEDGHGSGIENLVLSKWIPQNDLLNDKRLTLFVTHAGMGSTTEVAFSYVPALAIPVAGDQRRNAKLLERLKIGITAEKEILRDSKKFGEKILEVLNNEEYKINSIKTAEMLRNRPISSEELLVKHVEFACRFGQLPRLDLASKDMGVIEYYNLDIIIPFFTICSLIIYVIIKLLLKIISKFILKKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYS4</accession>
    <name>A0A0N5BYS4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYS4"/>
    <dbReference type="WBParaSite" id="SPAL_0001092300.1">
        <property type="protein sequence ID" value="SPAL_0001092300.1"/>
        <property type="gene ID" value="SPAL_0001092300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001092300.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19942" checksum="21032D2CB2AF5083" modified="2015-12-09" version="1">MAQLIYGITPYVWANNITTVKELRKYFFHKLKNWLPSQSFEKIVRTSFDEFLEEEYCHPYIKVTKPPKGKATFIPNPTYARDESPGLRINRRGIENTEEGIILDLNYHYYYKESTEQTYTIITEAENATRDHWWRNTENNEGTGTPGKSDWYTYLASMMQKPFKDTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZC5</accession>
    <name>A0A0N5BZC5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZC5"/>
    <dbReference type="STRING" id="174720.A0A0N5BZC5"/>
    <dbReference type="WBParaSite" id="SPAL_0001111800.1">
        <property type="protein sequence ID" value="SPAL_0001111800.1"/>
        <property type="gene ID" value="SPAL_0001111800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001111800.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35474" checksum="3C92A43928682585" modified="2015-12-09" version="1">MSQEKSKRFNVLYISQTDVNNFKYKYTIEKFPLRPEKTGEKIISPTFVIGGKKKSEWCLHIYPNGGEEESKEYVSVYLVLLKPDKAKAKYRFSILNDKEEEKNVKFATESEDFVNNDKGLAFSHFVKRDFLLNESNDLLVNGCLVIFCEAEIIYLKSENYDNLEIIDFKSENHDNLDTSINVTTPQSKLSLDYGNMFDSSLFYDCVIKVEDTEIQVHKAVLAARSPGFYNIFNSTSDQSQTNIIEIKDFNVGVVRKMLKYIYKDEVSDIRDMENEMFEIANKYELHRLKAISEQSMCNSLSVENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZY4</accession>
    <name>A0A0N5BZY4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZY4"/>
    <dbReference type="STRING" id="174720.A0A0N5BZY4"/>
    <dbReference type="WBParaSite" id="SPAL_0001132200.1">
        <property type="protein sequence ID" value="SPAL_0001132200.1"/>
        <property type="gene ID" value="SPAL_0001132200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="148"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001132200.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34726" checksum="902EC3356F6AB4F1" modified="2015-12-09" version="1">MVKVEILKVSSKDNHGVTVDVSNESTIGDVKKAYSKAANVQLERIALRNEIKGKNIKDDVKIDTFPNRQFFFRDLGPQIPWKTVFLLEYAGPFFIYPIFFLRPSFIYGGGASDAPVECSVKLALLCSTFHYGKRLFETQFIHRFSNGTMPQFNLFKNCGYYWGFCAFMAYFINHPLYTAPTFGKFQVYLGLTLFILSELGNLSIHILLRNLRPEGSKVRKIPKPDGNPFTLLFNYVSCPNYSYEFYSWIGFSIMTQSLPSVIFTVAGFIQMSIWALQKHRNYKKEFSDYPKKRKAIIPYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0I0</accession>
    <name>A0A0N5C0I0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuroglian</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C0I0"/>
    <dbReference type="WBParaSite" id="SPAL_0001150800.1">
        <property type="protein sequence ID" value="SPAL_0001150800.1"/>
        <property type="gene ID" value="SPAL_0001150800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001718">
        <property type="entry name" value="Neuroglian, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002807">
        <property type="entry name" value="Sensory AXon guidance"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF35">
        <property type="entry name" value="NEUROGLIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="161"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="270"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="363"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="462"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="553"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="771"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001150800.1"/>
        </source>
    </evidence>
    <sequence length="1346" mass="151084" checksum="4C24760107ACBF02" modified="2015-12-09" version="1">MANLAFNNSNYRQLCLNIPSLLIILLIIYTSTVTGVVKIDWASIPSPPRLIHEPNDPIIYFTVENTISSNSEMLDYLKERTLKCSGIGNPPPVYTWKKNGKPFNLAMYSDRIAQKPSDGSFVFSRLTADDEGEYQCEVSNDNGTAVSEKITLRQTWIHYFPKQRAEVVKVELGEPYSRNCTPPESNPPARVYWIFKGDEEGSFDSINSSHISTNEEGTIFFHYVKESDFKPNRYYTCTAENTKLKDYKFGSQFSLQVTTNRRRSLSSNVPPAEQYVNQSSPIALNGNTHKLHCFFSGYPEPKPKWYHNGHIISEDNNDGFLFESYGKTLVFNVTMNKAGRYDCKFPAHSDIDRSFNVVVEAAPYWPDQPPANTNTSEGETVIFDCKTSGKPPPVVTFYKNGVEMINPKAGEKWVIDGSKLTIYDVKKGIHGAGDNAVYQCKSENKHGYLWTNFYLNLLAFKPQLLEDSGEVEAVEGKELELSCKFFASPIANITWESPNLLGIPHEIIPVDPNGVGKLIITKVNEDTEGEYKCIGINKYGMATGASKVSVRKPTHLNDFEEPTLVHIAGEVLRLPCSAHHDNRLEVNYEWLVNGKPLDQDRLDSGAYEIDDDNTLIIKNPTQYDSAEYTCNANTKLDSATKSIQITIQDVPAPPHAAYITDCNEKDYTVKVNFEHLEDANVISPVKEFWSQYLPDPDVDNTAWRTHPVPVFAEQNEHIENGQRMVRASLTISLKPYGRYVFRVIARNAVGDSSPMKVKGSCETSPKPPFRNPSGVKVQGSQPDNLIVYWNAMPREEWNGPNFGYEIQYKPKSGGSWKSIEVSDPFANKQSIEFDEDRPFESYEVQVIAKNELGPAIVSPETIEGRTGEGDPGVTPTNFKLIKAGSTTAEFSWDPVDPSAVSGNFTGYQITHWYIDEDDDEYFTDMEDSDKESKSKKRRYISKERIKRSFNDEDKSIKIPNNKKTVIFSPEATGGIVTGLKPNAINYAQISVLNGQNAGTPTEPISFRTEEGVPTPVRRLGAYPMNNRSPGENGVIMVRWDKPKHIHGNLQHYTVEYCTIDEASGKTLQCHSPEIVPYDKTEIRLTNLTPDTRYRIKVYGNTNAGVGAPNSADAKTLSEDIATELHPETPTLTNIKVGEDNINLTFVPGDFDDNTKRPVGNSHIVQYREKGTDDWIELPTTDDTLEANIKNLEPGTKYDVQVVAQYTDEDGNIKQTPSRIHHIQTIGSSSKFGRFWWILLIILLLLLLCILLCIICLILRQRGQKYPVSEKERLQGREPMLGKDRNFGEYDNGTNEEGRSLAGHSQTGSETDSMAEYGDGDPGRFTEDGSFIGQYVPTKTLAPNSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0L6</accession>
    <name>A0A0N5C0L6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0L6"/>
    <dbReference type="STRING" id="174720.A0A0N5C0L6"/>
    <dbReference type="WBParaSite" id="SPAL_0001154400.1">
        <property type="protein sequence ID" value="SPAL_0001154400.1"/>
        <property type="gene ID" value="SPAL_0001154400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="229"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001154400.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42185" checksum="9B69E1B93F7CE37E" modified="2015-12-09" version="1">MFLSKFLKPNNIKICSSILYSNFHNEKFSSREIAHLSDQFTNIPKEDKNKTTFHAVLDIYLKNKTNTRGSVEFITTALKYMKEFNVHKDLDTYKVLLDSFPKGPLIPQNKMQKVFLHHPQQQHCCVKVLDEMEWNGVQPDKEIHDIVALTFGEWNFATKKAKRMLFWNPKIRHTNKYLDGRDIDNKNLNKLELAELALKMMSRDAGTNFSDAKSVDKNGNESFIVSAQSPLQRRLLFNLIRDYKDLTLYVDGPSLVYLREHQIKYVVLSCDDPEYSKDDDLLVMDNDSYYNVDDIVYGIEREFKKVKNIHQEDGKIILAMAVLEENTKESAMAWTRHLQEDNNNLGEAKILFRMKTSSIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1K5</accession>
    <name>A0A0N5C1K5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Proteasome activator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C1K5"/>
    <dbReference type="WBParaSite" id="SPAL_0001187900.1">
        <property type="protein sequence ID" value="SPAL_0001187900.1"/>
        <property type="gene ID" value="SPAL_0001187900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="363"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1237"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1807"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001187900.1"/>
        </source>
    </evidence>
    <sequence length="1892" mass="219559" checksum="9B43E61332715EF3" modified="2015-12-09" version="1">MSDDDMSDSDEYLTNSEGEDCLDEGEDGAEDVTMHDLETDEIDENGMNDDKGNSANGKRFQKDRWQLRHLPYYDDIVEEADEHFCRIKEGLANSILLREIKPGFTVWLKEFETYFDQYGYRFTKQDHIYLVKLAYGILECENLEYRIIKNAAIILTVLGKRRELLNYKDVTLDWRVLYRVYDTIINKHEEDRGKIIYPKGLRQSLEHCAQAIRQFFPPTALFEMTEELRQHMCIFENTVTFATNTLVYFAPFNFDGKDHKIARTTEWFDEIWNLAKQLETRSDFPIKLLQLFARLTRESPFVIDWRSKEEYLFTRLMTALSLGVTNENISLGDASTSMIEAIAQIIIFSLDGKNKDSLQHIVKFFRTIESYFHPSNCGSHTEHLMTVLGKFSSSMCSRLYREKAGSKSSFQPFPDDKKMTDEVLESFVSVFIKPCKFAAYSKSKSTLVVPTIKSLTFICPGIMIPTVIDMVYQGLETITEPHRLTQSLSLLHAIIVPLVRDTYEEGSGKTRLKVTTIPYDQPKETSFRLFAIELMNALINVIDMNDMQKTAHAFNALCNFFTLIPIVDCSEAIYHYKNLTEDEKLLCQASANFETMICNLFDKLTSLVESMGNQTLTGEGGGQGEVMTRRAHKLNIEEQLTRKGLSCIFQALLGNCSKDFNEMIITKLFHFIQSCMFNNKAAALILKDLITVCVRFNCDFAFPMFFKHLYKMTTIHLTKEILSEDEPDATFTWYFTQLISCINSAQGKMILRHSKEIEELIGIVLQFKSPLMHPRIGEFITGVVSRLCLINVDNSSINYFSKEKPLDEELPIRNWAKPLDKDKVCTKFYVPSNEEITFAEHLFNKFCVPFVETLKNPKELKDREMVKNLTFIFAFLEGIAFRLPYITGKRITIDKSYINPSLPDHICSPKSMKNITLPDGGSVRLYLLDVIVNLIDYILDHHEDNTRAITKIASILNFIIFSRGMFKNLTDNYAHSYEISRKMLNDPIRGRKMDLETIHHDHMFLLHLKRVQLRSCESFTEHHWRAIRAAWRMTLSTYTNTRCEAQTIISNALSIYNESSKFLIDDVLKYVDVKAKHEQLKGALHNILTGKRYNILMRQNWEMLNKMIPKLIMCQSTTRESITSVLDDIQSFLTDNFETFNIRYTVPDSIVKYAENLYIKYEGCVHYPKHPKPTDEEISMAKIREEENNCKKERLYYQLWDSLCNFVTDPTLHWRHREVSFSTMGLLLRKDMKVPDKAVHLLVKQIISDEAYSREEALNSLQSWLFITWPKSIDKEYVINVNNNKKPTMGYRKDNEFLLVADNVNLYSSEKWNNSRCFKYLNIGYYGWPKNKRAFAPPIEQPYHNMKFEDFPEIDRAVITTLRDPNYIKKFIEIYVHEEKKGDRLRPSVYTLFITLFAKYNILFFDAWKGAIEELLENKESGHQRLAAEFFTGPIDTWSLWTFDKVEHVWRWMEPLLYKTVLNMNSENQNHWCTAISIMCNKGDPRFIKCIIDLTIKAASVPSETNFHNNAKIAATYYAIHSCSWKAPSQWNKLSKICFAYLENSYQSVRDRITDVFSTTASYSLESTPKDPEIDKEFEALNHREILSMLSKECYNQLEKNVYVNIHSLQSSNKLTISPSSSECPSRNESYANLQITPEEKRALQYFKVLVDFVATTAHNNELGLSTEIIDTIPILAHYENDCDEDLAESCHAALLMNIARGYVNEDTCLHFLSVIKKSIENCFLWKAKVSLFKVLQVNIFSNIFVYARHTEQVYEIILPLLLSDRIEICNTAAESLTGFVMCGYLEVTDGLLKTFYSWASSSSSQQRHAGVLALSSVVLAYPYNVPEIMPDILMHLARMVGDEQHISRAVKKTFSEFKRTHWDNWVEHKECFNENQLLVLNDLLVSPTYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2C4</accession>
    <name>A0A0N5C2C4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">COX6C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2C4"/>
    <dbReference type="STRING" id="174720.A0A0N5C2C4"/>
    <dbReference type="WBParaSite" id="SPAL_0001213400.1">
        <property type="protein sequence ID" value="SPAL_0001213400.1"/>
        <property type="gene ID" value="SPAL_0001213400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001213400.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11593" checksum="C73D60EC343B9854" modified="2015-12-09" version="1">MAPVMRNIIHTSAKRAIYLGMVSGTISAAVYYATFVQPRQKKYEEFYANYDPYQRMREICATGKGYMHTCPEELVKLYEEKGIPIGSRAQAEAEESSEVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2H7</accession>
    <name>A0A0N5C2H7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="4">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2H7"/>
    <dbReference type="STRING" id="174720.A0A0N5C2H7"/>
    <dbReference type="WBParaSite" id="SPAL_0001218600.1">
        <property type="protein sequence ID" value="SPAL_0001218600.1"/>
        <property type="gene ID" value="SPAL_0001218600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000206">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049063">
        <property type="entry name" value="T6PP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041064">
        <property type="entry name" value="T6PP_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21141">
        <property type="entry name" value="T6PP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18572">
        <property type="entry name" value="T6PP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose-6-phosphate phosphatase helical bundle" evidence="8">
        <location>
            <begin position="824"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Trehalose-6-phosphate phosphatase C-terminal" evidence="9">
        <location>
            <begin position="960"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001218600.1"/>
        </source>
    </evidence>
    <sequence length="1254" mass="142031" checksum="632B5EE067AE23C3" modified="2015-12-09" version="1">MKIAETTASSILIKNNDEISLPDCIDNLQQPYHTTSLPFERNASEKIETPEQSTAILEKELSQLLCKLNIDNQVVCGDNIDKFISDCCAKFYEIWKSRCQSSEIALKGLVCILEYCLVFPLIRYDAFEELINTVGFSSILFWKNTVPLVYESDLSTGTQYRDSLLFSLELYDVNNGKNKVRELYAAVPGMQQSLLGMHAKRFGERFKFIQHMRSRRCSKAASSANSLSNEDICITDNDSSSDGFEIDQFPLEGGGLADIAQEKGRVINVSNAPPVSVSRRQSGSWEIKQGSGGLVACVDPVMSSDKENIWLANLGINVNLQADNESVDGNQSSILPSTNSLGLPLIKQAKAGDVFHVLADDKKKDDIEDPVERDMSLLNVLHDYNKSSYKLNPVIVTQDDYEAYYGGISNGLLWPALHNLPEYIVTEYDNVHTLKKHWCAYVRVNYQFALNAARNSRQQDFIWIHDYHLMLTGQMMKSLDSSLEVGFFLHIPFQPPDNFMTKYRVVAEPIVRGILRFNKVGFQTHRDRQKYVDIVQKYITRVKVSYDGVVDIFMVTYEGSTCSLGVFPVSIKNQDFIDIAKNAATIERSHDIKKELASKCDPDGKLFFSVERFDYTKGIRQKLLAWKMYFQRHPDRIGKDTLFQVAVTNRRTVESYRNYQDTCMAIAQEINDSVISDQYKEWKPVIFQTNGLNRKDLIAHYLAMDVGIVTPIKDGMNLVAKEMMICNSKATLVLSSGAGTEVQLTNAGLYSDSEKCYFRVEDINNTDEFADIFYKAASQSSEEVLCKGLKIKTFLMQHDIVEWSTSFLDPSWTHEVIRVSELKSLSDFYVLMEKTCKLRRQIVENILKGIALKSHFDISLKNALETLEKSCTDGHFLNLITESVSLDGSSVIAKLDINDQLQELNKDIEFLRFIQSDNVNNVEEFVATLSKYHPVSDEAFEEEVSNAVDILTEGDHFDHFFTDRDGTLKSYCCSYASSIQPAYSAVIQAQFARRCAQFCAIVTTAPLLNIGILNVSTMPEGYYVYGASGGREWYMNPAVQFKDSKIGHDELELFDIVFEKLEQITELPEYEHLKWIGSGIQKHYGHITIACQDKNQGICDSSSQKLLEIVQNIVNEVDPIEETLLVTMDNIREIKICIKSDNSDQIFNKGNGIMLIKEKMGLKLHKGNILICGDALTDLPMLEEVLKISPKNVYTIWVTIDESLKGKVAEMCKKYGNEFYTFVSCPTVLLAAMAHATVRDIRIRPHILELDDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C311</accession>
    <name>A0A0N5C311_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C311"/>
    <dbReference type="STRING" id="174720.A0A0N5C311"/>
    <dbReference type="WBParaSite" id="SPAL_0001236600.1">
        <property type="protein sequence ID" value="SPAL_0001236600.1"/>
        <property type="gene ID" value="SPAL_0001236600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001236600.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13134" checksum="A18E9410954F0FCD" modified="2015-12-09" version="1">MERINQSTGTTVTRAQTVTISESRLAQEPLILRLKPIQVDKKEEIHVKWDESVIDNEHLGRKKSNCCCIYVPPREWDKPETRKRNEYETEFCRGHTEVNHPNSGEHKEENCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3K0</accession>
    <name>A0A0N5C3K0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3K0"/>
    <dbReference type="WBParaSite" id="SPAL_0001254500.1">
        <property type="protein sequence ID" value="SPAL_0001254500.1"/>
        <property type="gene ID" value="SPAL_0001254500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001254500.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11999" checksum="9E0F36912CCEF078" modified="2015-12-09" version="1">MQLLRLIQDQLYWIDIKINGYDESLRYIIRGFDPFVSALWMFINAASIILISKTLRDAIFENLKFDVVYKKLFRKNIVVKISYNSNIIQNINRGTKKKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3N7</accession>
    <name>A0A0N5C3N7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3N7"/>
    <dbReference type="STRING" id="174720.A0A0N5C3N7"/>
    <dbReference type="WBParaSite" id="SPAL_0001257800.1">
        <property type="protein sequence ID" value="SPAL_0001257800.1"/>
        <property type="gene ID" value="SPAL_0001257800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001257800.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8743" checksum="813AC82F44759811" modified="2015-12-09" version="1">MNVIEIKNFRPEVVQGMLEYVYKDKISNVRNMHSEMLAIAVEYGLDRLKAVAVEYLCDHLTVENVCEHLILSEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4C9</accession>
    <name>A0A0N5C4C9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4C9"/>
    <dbReference type="WBParaSite" id="SPAL_0001281000.1">
        <property type="protein sequence ID" value="SPAL_0001281000.1"/>
        <property type="gene ID" value="SPAL_0001281000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001281000.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9513" checksum="F9F630DA746C6375" modified="2015-12-09" version="1">MLQHIEDFRNDFNKLVQCIEKLRERADKLREENKELKKHICNLKKGNFLYEEMVNENKMLKEKILMLQKGFENQSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4J6</accession>
    <name>A0A0N5C4J6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4J6"/>
    <dbReference type="WBParaSite" id="SPAL_0001287700.1">
        <property type="protein sequence ID" value="SPAL_0001287700.1"/>
        <property type="gene ID" value="SPAL_0001287700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001287700.1"/>
        </source>
    </evidence>
    <sequence length="26" mass="2930" checksum="8034A673739A25E9" modified="2015-12-09" version="1">MEGEIEPHISIHQVFLILVLKNGILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4N6</accession>
    <name>A0A0N5C4N6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4N6"/>
    <dbReference type="STRING" id="174720.A0A0N5C4N6"/>
    <dbReference type="WBParaSite" id="SPAL_0001291600.1">
        <property type="protein sequence ID" value="SPAL_0001291600.1"/>
        <property type="gene ID" value="SPAL_0001291600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF20">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 9" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001291600.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69784" checksum="B459E7B9F0388ADE" modified="2015-12-09" version="1">MAPGSKREKNHAPSDEVEIKFVPVRNSPGNGTLVQKNGHSEIERGQWTGPFDFLMSMIAYAVGLGNVWRFPYLCFKNGGGSFLVVYAIFFILGAVPIFIMEVTVGQYLQRGAMEMWNMCPIFKGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSFNSTFPWETCNNWWNNGQCITGKENITTLQSLVSNLTSYNLKTETSVEQFWERRVLQQTDSISEFGGIQWELFGLMLLAWIIVYFALWKGITQARKFVYFCALFPYFLLFVLLIRGLTLPGAMTGISFYLTPNMTKLLDTTVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNCFRDAFLMCCINGSTSILAGFVVFSILGYMSVIANKDIAEIVKPGVGLAFQAYPEVASNLPMKQIWAILFFMMIVILGLDSQVCMMEGLFTALEDAFPTVLRKHKKVSLGVTCLIFFIIGIPMVTYGGAYWLTLIDAYGASGIALLFVVFFEVVGLSWGFGADRIRHALHEMIGIKTSLFWNLIWKFCAPLVTLLLFIFCLVMYHPLKYPNGESFPVWAEVLGFILSSCSMIVIPGYAIYYLFFKKSGLTFKEKLHCGLHPPPNAFDHIQKHYQPGEEMDFIDSEQRKRIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4T0</accession>
    <name>A0A0N5C4T0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphate carrier protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4T0"/>
    <dbReference type="STRING" id="174720.A0A0N5C4T0"/>
    <dbReference type="WBParaSite" id="SPAL_0001296100.1">
        <property type="protein sequence ID" value="SPAL_0001296100.1"/>
        <property type="gene ID" value="SPAL_0001296100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="242"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001296100.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37852" checksum="146CB6AE36240076" modified="2015-12-09" version="1">MVGYVEKAAEMMKSNPFSSPLPRIAECSTGSSGNGDAVELGSLKYYSLCALGGAISCGVTHTAIVPLDLVKCRIQVNPEKYKGIISGFKTTISEEGGRALAKGWAPTLYGYSMQGLGKFGFYELFKNVYADMIGEENAYLYRTYLYLAASASAEFFADMLLAPMEATKVRIQTSPGAPPTLRGCAPMIYKQEGLMGFYKGLPPLWMRQIPYTMMKFACFERTVELLYKYVVPKPRENCSKAEQLGVTFLAGYIAGVFCAVVSHPADTVVSKLNQDASASAGDILKKLGFAGVWKGLTPRIIMIGTLTALQWFIYDTVKVVFNLPRPPPPSMPESLKKKLEAAGKPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4U6</accession>
    <name>A0A0N5C4U6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C4U6"/>
    <dbReference type="WBParaSite" id="SPAL_0001297500.1">
        <property type="protein sequence ID" value="SPAL_0001297500.1"/>
        <property type="gene ID" value="SPAL_0001297500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001297500.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="40498" checksum="32815294C5F2D878" modified="2015-12-09" version="1">XVNTTTDNSIKDILYPHQIAIIMVIANATEHNFEQAIETVKCYSWHYNYTFVILRIEKVSEFIYNCIYFDFMFLRHCIIANYAQKNKKEIKYIVFIDGDMGVVNPLHKLENYLPKGEEDILFYDRIFNNEIAAGSYIIRNTLFARSFLKFFADYDYKIPENSAGSDNIALQAVFVDFMGTVEHRKKYLQCMEIYNYAKGYNQFMVFVSCMRYILSLIDETPNDIDYHTYEGGKIKVVRKLSKKRWVRDGWLSEWKFCDDELFHHAWRQEEIEQRKIIFKTRFLANKSICKNSDFSKLWDYDKSFIKDCKTIDDSIKSYVNNGYSQYMKDLNESNVTKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4V4</accession>
    <name>A0A0N5C4V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4V4"/>
    <dbReference type="WBParaSite" id="SPAL_0001298300.1">
        <property type="protein sequence ID" value="SPAL_0001298300.1"/>
        <property type="gene ID" value="SPAL_0001298300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001298300.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12701" checksum="04F61E57E1A14F87" modified="2016-05-11" version="2">MDPTTGTMNIELPKYTDMSKDIGPFLRRMTILLDSQNLDDARKQAMLKIQLPDACLDFLEGKEFANYNALVNSLKEKYNGQISKTTAQSRLLSFQFEFKDVEKGILKFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4Y6</accession>
    <name>A0A0N5C4Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001301300.1">
        <property type="protein sequence ID" value="SPAL_0001301300.1"/>
        <property type="gene ID" value="SPAL_0001301300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001301300.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28644" checksum="11A5524335ADB691" modified="2015-12-09" version="1">MSRIAFRCILNIRSCSTVTSKFDIRFTTPADREQLDILLKRGFHEGENLIKMLDLTYEEMKPVYDKILSNKFTINNSLCAVNNYNGEICATIIFKLLTRGNNYKNYVDESEEEYFKRVVNGNDKLKKCFDIQEKCCEDVWKVFPNDINSIWKTFMLAVLPEYRNMKLASLIMKSREKLCPERFPDLYGDIADCTTLASVKIQNNCGYKNYSKVPYSYIGLPPAPDGSDSVIGNYKILPHYYENKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5M8</accession>
    <name>A0A0N5C5M8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IGFBP N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5M8"/>
    <dbReference type="WBParaSite" id="SPAL_0001325500.1">
        <property type="protein sequence ID" value="SPAL_0001325500.1"/>
        <property type="gene ID" value="SPAL_0001325500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001325500.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="7250" checksum="4D387B35678F278A" modified="2015-12-09" version="1">MIVFNKCILGCSAPAPSCGGGGGCAAPPPPPPPPAPSCGGGCSAPAPAPSCGGGCAAPPPPPPPAPSCGGGKILELNHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5P2</accession>
    <name>A0A0N5C5P2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-nucleotidase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5P2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5P2"/>
    <dbReference type="WBParaSite" id="SPAL_0001326900.1">
        <property type="protein sequence ID" value="SPAL_0001326900.1"/>
        <property type="gene ID" value="SPAL_0001326900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001326900.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57869" checksum="A7BCCDAA8534B0F9" modified="2015-12-09" version="1">MLRIMTKRSISLHNKCSKNKEIMNMYNESKAKIEMITLKRPINPRGVFAQNELNLRHIGAFGFDYDYTLCVYKKELNKLIYNLTMNVLIEDKKYPNALKSLPYDFDFAIRGLHFDIENSCLLKIDAFNTIQPGSVYRGRRRLTDEEILKQYKSFNLPDSKIKKMMQLNDLFSLPWAGILSNIVDYCDNVIGNVIAYTLHDDVKEAVGKVHSSGMMYKAVMENIENYVHPNENLRPYFETLLKNKSKELFIISNSPYNFINAGMTYMMGDDWRHFFKYIIVSAKKPDFFKKDTPFRLYDEQLNTVVWFRQVDELEKGKIYCNGNINAFSKMANFKNPNVLYFGDHMFSDLADPILQLGWRTAAIVPELAREIRLQNQNDYIRNILWIDALTEIYERYQYLEDECNDCAKILTELENERKEARESAKAKFNPQFGSLFRTYNNMTYFSKRLSRLADIYTSRVSNLNNYSDRHSFYARRNALPHETSLGFSKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5R2</accession>
    <name>A0A0N5C5R2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">PBPe domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5R2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5R2"/>
    <dbReference type="WBParaSite" id="SPAL_0001328900.1">
        <property type="protein sequence ID" value="SPAL_0001328900.1"/>
        <property type="gene ID" value="SPAL_0001328900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000255">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="46"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001328900.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="65623" checksum="432949D828547176" modified="2015-12-09" version="1">MLKDTLRGERDTIDKEFQDGWNFDKNFEKTWHYGLDSTSSNFNGQNLKIVVYLEEPFVTRANNSIGYEGFCIDLIKEMSLILNFTWTILEVKDGAYGVEDDIGKWNGVIGMLQKHEADLSVSALTITYSRSSVVDFTLPFMHLGIAILLGKQSDDSQNNSLFTFLEPLSFSVWISLLAAYLIVSCTMWLLARFSPYEWFDVQQIDERDKSMDNHKNQFSLLNSLWFAVGSLMQQGSDVIPRAAATRTVAVVWWMFTLILISTYTAQLAAFLTVERMTTPIESAGDLASQQKIKFGTLRNGSTMDFFRESKIPIYERMWSVMQSNSPYSFVNSSKEGIARVKAGNYAYMMESSMLEYYMEKDCELQTIGGLLDSKGYGIALPKGSPLRHIFSKTVLQLQERTILEALKNKWWKSRRELKKCSQYSTTKGSFQSVFGIFYVLLAGLIIAVLMSCGEFCIESRENNFRLELTIPGKIFMLLFSRRKSKNRKKLLNIQLDEIDNGESNSYSIKYDPDLHSALSSIDNRSNGQLSISPRHNSFDFSGDIRRFSRFIPLNEGNLITRRMSTYSATRESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5V7</accession>
    <name>A0A0N5C5V7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5V7"/>
    <dbReference type="STRING" id="174720.A0A0N5C5V7"/>
    <dbReference type="WBParaSite" id="SPAL_0001333300.1">
        <property type="protein sequence ID" value="SPAL_0001333300.1"/>
        <property type="gene ID" value="SPAL_0001333300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333300.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="57132" checksum="40C5BA2DB6B4574B" modified="2015-12-09" version="1">MIGILLLLFTIYYVFNFYKKVKSLPPGPTPFPIIGNLFSFDFKKLHLWIHGQKKTYGNVFTVWLPAPQVVFADYDSITEALVKNDDNFIGRNVDGFPDKAFHEKLNVGVIFSEGEEWRDQRRLSLHILRDFGMSRTIIQDKIYLVIQDIYDHIENLENKDNVNIDKILQLSVGNVINLILFGSMFYSTEDNEFFKFAEALEDFAKGASKWEFRVLLLFPSIDKIPILNNYLYKRITRTQRKMRELAKIQVEKCKKTYKPDDEPPNFIHAFMKETQSTDSKYSYLNSDHLEAIVLDFWTGGVETTYTALRWFILLCMKHLDIQKKLQDEIDEVIGKDRLVQLSDKSKLPYMNAFINEGQRYTNIVAFVPKHKCTKDTVINGHLIPKDTIIDPFYWGANMDEKYFKDSYVFNPNRFLDDEGKFKVEYDHMSFGKGKRICAGKSLAETEIFLIFTSLLQKYKFTHPNGPVDLSFDFSGVLQPKTYTCKIEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C679</accession>
    <name>A0A0N5C679_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C679"/>
    <dbReference type="STRING" id="174720.A0A0N5C679"/>
    <dbReference type="WBParaSite" id="SPAL_0001345300.1">
        <property type="protein sequence ID" value="SPAL_0001345300.1"/>
        <property type="gene ID" value="SPAL_0001345300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF108">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895525" evidence="6">
        <location>
            <begin position="22"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="13"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001345300.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52470" checksum="C13752A62F59A5FA" modified="2015-12-09" version="1">MTSKNTLKLMLIGLILSTCSIFQMGYSNAYVNTSMSEFKIFLNESFKSQDIPLTSYTYYWLWSGILNVWFIGFLLGTCISIPITDIFGRKVGLIFANSLTSISVIIMGTSIFIKSIVLLIIGRILSALSAGIAMSSLILFLQEIAPPNLRGTLSFYAELSFVLTNAIGAFGGMPSVFGGNLPLLIMLALIPSSIVTCLLIFLYETPIFLYSVKKNENDALKSISFYHGTNNKAVQLEFLVNNSSEGQQKLSFKNLKDLFTINYLRKGLILGFLSLQITCSIWPIIYYSADFLMKANVSEELSQLFSTIMLIVSVFATFCGQYAVEKFSRRLLFISVSLINILALTLFWLFDQTRIHTNIDNFKYGCVSAVFLHGISYSFATGPIAWFIEAELIPITHRLLAQTFCLSANHLSALILTFITLPLYNIIGSHTIFLLFVLPSSVSLIWIYKYLPETKGKTSNEVIEMLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6L9</accession>
    <name>A0A0N5C6L9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6L9"/>
    <dbReference type="WBParaSite" id="SPAL_0001358500.1">
        <property type="protein sequence ID" value="SPAL_0001358500.1"/>
        <property type="gene ID" value="SPAL_0001358500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001358500.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13899" checksum="A62436BDF0FC8FFF" modified="2015-12-09" version="1">MKLRASSKRKPGYFSRLLKTTQENSAINHTMHIEISLSESKNDPLGSVGITPSSSRNNSCTNSPKRNRSIVKRNISSSGNITYDEKLILQLRYLLNHIILPNMCVVPSLKKLYKEILKIVDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6M4</accession>
    <name>A0A0N5C6M4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6M4"/>
    <dbReference type="STRING" id="174720.A0A0N5C6M4"/>
    <dbReference type="WBParaSite" id="SPAL_0001359000.1">
        <property type="protein sequence ID" value="SPAL_0001359000.1"/>
        <property type="gene ID" value="SPAL_0001359000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="13"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001359000.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24274" checksum="0CCCFFAC9C5C94AA" modified="2015-12-09" version="1">MYREHSVYNMSKTIIGKPAPEFTLEGVFEYDFKMISLSDYKGKYVVLFFYPNDFTFVCPTEIIAFSERIKEFEEVDTVVLACSCDSKYSHFAWISMPRKEGGLGEMKIPVLSDFTKRIARDYGVLKEDEGSSFRGLFIIDRDGILRQITINDMSVGRSVDETLRLVKAFQYTDKHGEVCPANWKPGDKTINPTISDAKKFFEAENDNENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6P3</accession>
    <name>A0A0N5C6P3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TAPT1 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6P3"/>
    <dbReference type="STRING" id="174720.A0A0N5C6P3"/>
    <dbReference type="WBParaSite" id="SPAL_0001360900.1">
        <property type="protein sequence ID" value="SPAL_0001360900.1"/>
        <property type="gene ID" value="SPAL_0001360900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001360900.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="62214" checksum="49B0E36BA888F051" modified="2015-12-09" version="1">MDEIGEGYSDTPQLRRRFLGSVTEEIDIKCDENVSSDLISEEEVPKTCGFEGEKLKIKIETDEELKEEVVDEIDEPTENETLCEENNNKEQSKVRNYKKCKFTIWQFFIDEISRGYCLQNDSKRFTEKRRKVYAFLNIPLELEKFFLFGIFQCMDAFIYVFTFLPIKILFNFLTILLRFKNWGSSDSINVIKLLTIVLCSTLMQFIDTSVIYHQVRGQAIIKLYIFYNMLEVVDKLCSSFGQDTFDALYLTVSENDKHKKLPHIIILFTFSIVFSFMHTLIILLQATTLNVAFNSHNQALLTIMISNNFVELKGSVFKKFGKPNLFQMACSDVRERFHTFILLVVVVLRNMTAVNWQVDHFIEMWLDLVLVIIAEIAIDWFKHAFITKFNEINADVYKDFTLTLAFDVVRCKEENAFTDFSDQVARRMGFIPIHLLILLLRIISQSVSMSNFTVVLLGSIWILLFIVKILNGYLLYTLSCHLISQYREMQLKLDEDDARNRVVSSKSKSAPSSPKISILDFSDILTQAQNKNTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C716</accession>
    <name>A0A0N5C716_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C716"/>
    <dbReference type="WBParaSite" id="SPAL_0001373100.1">
        <property type="protein sequence ID" value="SPAL_0001373100.1"/>
        <property type="gene ID" value="SPAL_0001373100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001373100.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29554" checksum="77E3A2FE1DFA9D72" modified="2015-12-09" version="1">MGKYNGYSRPYGYQPAPTAAPSLSVTINQNNASTTEAPPYQKSPISPPIPTPPKTPRPNVPPPVAPSAPPDYDPDGYQSYSNPMWLDRFVRRENRGMFRLCLFEAMLALVIFGGGIWCARDTPDYCPYYSPIWTSIFYIINAIVGSIAAKRGSLKLYMSHLTLSMIALAMCIVSGIISAKNWVAVGTYTHPKLSRNHAFCLIGQHDASRISYIFSHMDRYDFSGCLFSLKVGIAVNSIQFVVAAIEAFLNLLSVLLCMKRTCSSPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAN1</accession>
    <name>A0A0N5CAN1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAN1"/>
    <dbReference type="WBParaSite" id="SPAL_0001495100.1">
        <property type="protein sequence ID" value="SPAL_0001495100.1"/>
        <property type="gene ID" value="SPAL_0001495100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001495100.1"/>
        </source>
    </evidence>
    <sequence length="826" mass="96437" checksum="A59EFB26B838B051" modified="2015-12-09" version="1">MQVLKEKTTFSKDKKFTFNVRKSNDCHSEKRSQNEESELPTFIIPDLSKSKAITKNVNKILKNKKFQESFKKENHNCEEASKSNKISSNTLYTKTYENEVSEQSKDFCLLTNTLTNKYSTLDENLKIQVDEVKENQGLISEELNDFYDQIIDLKKCGENIVLKNSNYDQKIKISSKNFEDFVDEIKQIKNTNETIKNIYECNIKILTEEIKNNETKIKSQSESINLFKSKIFEISNNLLKYKEENEQLKKINEEIKGENEKLRIALQNSNQTVNKAQEIIQELRGQATENEIEIGILNSQIKKSDKSQPSAGKDIKIFTRDLKMFIFSMLENCHNYNDINNMVKKSINHFLNREIDDDMSQKLLCKWQKEFKVCSVYVSGYMLEEFIRKKGKGVLIQRKITLKNKKLQTFVLCGNAEGRFYEILLGAIEVKNNSAEYMVKCFEELLETLANVTNNLKEDFILDIYNAIYGYMNDNTRSGKKIYNLFNEKVYFGKDPNDIRKYITYSSISCIGINILKTIEKLVYNLTEGKKIFVFLRNISKELCQENCNYYPSAVAFNNFIKNKLIREKNEGKKAIKPESKISSIEGSSTQMYGIICQDIIYSYSDLIEFSKINENRFDICKKILSMLSSKEVMNFLIFIAYVNEMFVYPIIRAASSTDIKEFVSYIKNIINEVEVYEFSKLPDIQKMILNYGNNYTFFKYGTLSILSNMMKKTFKDDTIGKEMIVKVLKETVKNVKKEFINVYERINENDDQTGRFLKIQTKIIANNVFSQVKQNSLEIPYKDITMISSQVRASYNKMTEVLEQMTQSKVDSMLELRLPFEEYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBM3</accession>
    <name>A0A0N5CBM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBM3"/>
    <dbReference type="STRING" id="174720.A0A0N5CBM3"/>
    <dbReference type="WBParaSite" id="SPAL_0001529000.1">
        <property type="protein sequence ID" value="SPAL_0001529000.1"/>
        <property type="gene ID" value="SPAL_0001529000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529000.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="57334" checksum="14312A0BD3F40D8C" modified="2015-12-09" version="1">MIGILILIIVTIYLINFYRKVKSLPPGPMPLPILGNLLSFDFRKTHLWIYDQKKIYGNVFTIWIPKPHVVFADYDSINEALVKNDDNFLGRNVNGYPEKLINDKLNTGVIFSEGEEWRDQRRLSLHILRNFGMSRTIIQDKIHLVVHDFYEYVDSLNEKDNVDIEKILQLSTGNVINLILFGFMYSHTDNDEYFEFIEAHENLLKLTASWEIKLLTLIPFMDKILFLRNYLCRRVVGLVRKIKRITKYQIEQCKKSYNPDNEPPNFIHAVMKEIQSVDSKYSYLNSDHLEAIVLNFWLAGRETIATTLKWFVLFIMKHLDIQKKLQDEIDEVIGRDRLVQLSDRAKMSYMNAFIAEGQRFANIIGLAPLHRCTKDTVVNEHLIPNNTIIQPFYWGANMDEKYFKDPFTFNPNRFIDSEGKFRMEHEHMSFGRGKRICAGKSLADAELFLFFTSFLQKYKFSHPYGPVDLTSDSGLALIPRPFKCKIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC94</accession>
    <name>A0A0N5CC94_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunoglobulin-binding protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC94"/>
    <dbReference type="STRING" id="174720.A0A0N5CC94"/>
    <dbReference type="WBParaSite" id="SPAL_0001550300.1">
        <property type="protein sequence ID" value="SPAL_0001550300.1"/>
        <property type="gene ID" value="SPAL_0001550300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001550300.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38578" checksum="8A2552C3A3779127" modified="2015-12-09" version="1">MGETNDCTVGEIFEKYRDLILKEDGNFSDKQSLLIDSIEEMKKLKSNLEMSNIISLNEQIDEISSTNLEMLLLPYLIGVAYYNVRATDQEKRMDVLSNVRAYMREYLEELRMYSIIGFTLPWLRDIEDESSEGPSVSSKDKLTPSEKRERIIKRHQMYKNLEDQLKEYEQEASTSGGLDEVTQRNYVLAKMRTYALKAMMDLEKVDEEYDILEHMLKIKRGEIAEEKPKPPVKLSTYRIVRNEEQKKVFGMGYKNIPTLTVDEWYREMDKKGHFNVKQDSGLPSNGQDDTDEDDLDEEKEEARRQKQISWDEYTDYHRSGWGNTYNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCN6</accession>
    <name>A0A0N5CCN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ephrin RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCN6"/>
    <dbReference type="WBParaSite" id="SPAL_0001563800.1">
        <property type="protein sequence ID" value="SPAL_0001563800.1"/>
        <property type="gene ID" value="SPAL_0001563800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895695" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="2">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001563800.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24027" checksum="DCE090B676AF5177" modified="2015-12-09" version="1">MYFVAAVLALVELSIYSQGTTHEHLFPDIPKNLETGTFPYDITIYSRSDVVAVKCPISGYHHNSELSNFYQSFEYRLYEPLPKATIGWEIIDTINYQKYKTLFCGETEIYKTINGTSEYFGQTGWEYRINWKDNPDPKKLATEKKEYACSESVPEKCGSSIEDLIILRKRGSGRSKQLDISITRKVPAELLFYFFKKPNEDDELNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCN8</accession>
    <name>A0A0N5CCN8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCN8"/>
    <dbReference type="STRING" id="174720.A0A0N5CCN8"/>
    <dbReference type="WBParaSite" id="SPAL_0001563968.1">
        <property type="protein sequence ID" value="SPAL_0001563968.1"/>
        <property type="gene ID" value="SPAL_0001563968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001563968.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="11265" checksum="46634CDD26DE9A33" modified="2015-12-09" version="1">MLPVHDIAKINGDTYLYSEINILYQTIDFYDLYQRNIVIKLFGLNSDQLNNLRLQVYLGHFSNGISAQNMLHWVQIPHSRKQEMYNYRNEKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDM4</accession>
    <name>A0A0N5CDM4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDM4"/>
    <dbReference type="STRING" id="174720.A0A0N5CDM4"/>
    <dbReference type="WBParaSite" id="SPAL_0001596800.1">
        <property type="protein sequence ID" value="SPAL_0001596800.1"/>
        <property type="gene ID" value="SPAL_0001596800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF30">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001596800.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32314" checksum="EA9D0C7F073FDC4E" modified="2015-12-09" version="1">MAKNSSVPYVSMTDILFSDQWSNTDAKYFMSHWVPTCGWISLAYVVVVFVGQRIMKNRDAFDLQKVVGLWNLGFSLFSAIDLYFLLPELIWSINNLGFFGSYCYNAEYYTNQTTGYWGWMFVMSKLPELGDTMLLILRKKPVIFMHWYHHALTFYYAALTYSESQAWARWSLVMNLFVHTIMYFYFGTSALGKRYPNAFRQFITSIQLIQFIISVGIFSHLVYIMTLGNVEGCNTSWNVLALGGVMYLSYLYLFAKFFYKAYIAPKKVSDKKSKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEF0</accession>
    <name>A0A0N5CEF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEF0"/>
    <dbReference type="WBParaSite" id="SPAL_0001623900.1">
        <property type="protein sequence ID" value="SPAL_0001623900.1"/>
        <property type="gene ID" value="SPAL_0001623900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895752" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001623900.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9504" checksum="8ADA26355D6D1438" modified="2015-12-09" version="1">MSRINLTKVLSYFLLIITLIGSLTINTVESASYGEYLISYDNINKRSSPMMKWYSNSKRGGDLCGCNMGCFYRSFGACSACCSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEN7</accession>
    <name>A0A0N5CEN7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEN7"/>
    <dbReference type="STRING" id="174720.A0A0N5CEN7"/>
    <dbReference type="WBParaSite" id="SPAL_0001632500.1">
        <property type="protein sequence ID" value="SPAL_0001632500.1"/>
        <property type="gene ID" value="SPAL_0001632500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524:SF5">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="197"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001632500.1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111908" checksum="E261C47D4827ADEE" modified="2015-12-09" version="1">MDFLKYLKSNDSSSGKNHLHDERIAKQKKTYTKWVNNVLQDHGSPYRVKDLYDDLRSGVVLADVVYAFTGVRLKVSTPSSLDDKVIMSSNLSLVLESMRSDGIDLVNNNIGDIYDGKPKIVLGLIWQMILHYDIRRSIQHHQDLSYSDTDRSFSSHENGSIKSYKSSPTNKIKNVVMSPITSYKKKKEKKKRTIERGQCNKIILSWLEREICVPYGIKISNFSSDWKDGVAFMALVHKFCPSLVDMEIVRKSTSYDNISCAFKYAFEYLGIKSILEVDDILCDFPEDSAITLYVSQFMKIDALRLEDEDKAVGKIGTPEDLPLLDGAISSSPIGNAVVTEKVVVREESVEEEIQTRQFILAGGPLSTVSEESCEDASMDSQYVMNACKQMKNVVYGDHDDYSIEFVREPTDSFIVSSETNDSVFERSIVSKSERTMDEEVVQFTENNNLPSPNDVIESYDRGLENIFSSIFGSGAPEDNSGNTSNFCDVESATSYVKQLTSSVGLGMEITDDSVVSTDTDSGDEGDIECCLDEMPSFRNKSFFDDSQESSSTSETIVQSATSANLDVVETVDSLVDAVVALMEMDSKSGSEVSAVSNESQSIVDETDYEDDYVEESVCSNKTEDVTCGDTLNDVGKIEEERTDSTQEAENANLCEDDSGETPYSVEEGQGDNFHLMPWLMAPFEKVYEMMNDSGAGEYVEGYSTSLKATSLQDCVAEEAVGDCSLLPTSDITLDLNESSPLNTSSLNASVENHEDAGNEDNSMDESLLNEVANIKEIVEDIASKVQSIPGDRSGQHYNFSDRVNEELLSLDFPEKSIEEQIKDIAEAVGTLSTVYTEGLQKIEENSESEESPNQDVTEDMGSVTDSENPCNECADVSPATPAHMLEVCPEYPDSCVNNNNLDGSLLDKDTGLRVRFAESSGEEKPLCTSNDTLEVDSIDEVDEASTLGVKEVPKTHSSYTFGMLLLFVIMLVGILCFVYDCAKCLGGCGSTSSSSSLCCAPFEMRIQRLGGHVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF94</accession>
    <name>A0A0N5CF94_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1835 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF94"/>
    <dbReference type="STRING" id="174720.A0A0N5CF94"/>
    <dbReference type="WBParaSite" id="SPAL_0001653300.1">
        <property type="protein sequence ID" value="SPAL_0001653300.1"/>
        <property type="gene ID" value="SPAL_0001653300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001653300.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32408" checksum="BC8ED5346C4F63B9" modified="2015-12-09" version="1">MEKDFMPYVLILYGSRIGCAYAETLVEVIDGLEYEEGEDYCSIAYYMSLSLDRILKCLKEKALTPSEKCLLIDIRTSMGFDSYTEDDVLGTLNMRKENFLRMVNLKERYNLSFKYKQFIGLSNEDIGVHIVEKMLLIEDEMETIYSGVLKPYCQEYMLDRKSLICDFVGKWSAQQTFITGDGRVGMLKNKVSSICKLVSKINDPVLQIRCLQDLADAVPYNWPKELTQSVYSILFDSTIAKDIKSDLADRCTFSEICQIIKVYKDVPYDIGNIIDTELNLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFQ0</accession>
    <name>A0A0N5CFQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5CFQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001668400.1">
        <property type="protein sequence ID" value="SPAL_0001668400.1"/>
        <property type="gene ID" value="SPAL_0001668400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="73"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001668400.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56609" checksum="0B3E635E521C276D" modified="2015-12-09" version="1">MKPEVNKLDVDIELDKILHENEVAFSKNDNDISETNFFKHKIIVKDHPPIREKKRPTPLALQKLVKKKLDEMLKNKIIRPSTSPWSAPLQIVAKGTDDVRLCVDYRKLNRIIKLDAYSLPNIQLLLQSLHDKAVFTNLDLTKGYWQIGLTECSKQYTAFSCDYGLFEFNKLPFGLATSPAEFERMMELVFRDLIQRKVVFVYLDDILIATKTVHEHLEVLELVLKRVIKYKLKINKTKSNFCKSTIPFLGFDISAEGVKIDKVKQAKILNFEIPTNHATLQSYLGFINYFRNFIPNCAVLLSDLYLCLNNKTKFDFNSKCLNAFNKIKEILLKGDALIQPDIEGAIDGSNPFSIFIDASYSGIGACLMQRYEKHLRPIMFFSRAPQGAEKNYHISDLEALSLVSALKRFKNIIYHTKVKIYTDHAPLVSFFTKTNLANRLLRWALLIQEYNIEIIHIKGSSNAIEDYLSRSGWKNSKEPKLEEFKKIKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGH5</accession>
    <name>A0A0N5CGH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGH5"/>
    <dbReference type="WBParaSite" id="SPAL_0001695100.1">
        <property type="protein sequence ID" value="SPAL_0001695100.1"/>
        <property type="gene ID" value="SPAL_0001695100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895836" evidence="2">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001695100.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17887" checksum="8CE95BDB183F76E3" modified="2015-12-09" version="1">MHSMKYLAILILLIVQYSFQESSVENSSSSDDNEVVTPSLEEKSLPDALSLVDNDETGAYGLKNNVEENGREKNKKSLFGKSFTNSHFMKKLKTRSNKAGKTLKKSFKKMGGFFNKGKDALKKLIKKGKASSSSSSSSDSSEEINNREKRFLVIVEDIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH71</accession>
    <name>A0A0N5CH71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5857 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH71"/>
    <dbReference type="STRING" id="174720.A0A0N5CH71"/>
    <dbReference type="WBParaSite" id="SPAL_0001719300.1">
        <property type="protein sequence ID" value="SPAL_0001719300.1"/>
        <property type="gene ID" value="SPAL_0001719300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895874" evidence="1">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001719300.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36908" checksum="6A1D1EDC20337BD6" modified="2015-12-09" version="1">MLIILISLIILLTMPLIDSNCSTFQNYYFLGNLTKTNESEIECKDKKEDCVYISIDFPALAIGSLQSCSSKVSEILTKIFEERLDILELLYKIKNNKTNLYEVDYFCKNYNAKVWEENSMSGKIKLYTDCYEQNTIFNETNIIKFKPPISSAVPVLCYNDEENYKTCTEGFCSNFQISYLAEPGNYQQKASMITCPNSIFNFLEDLNCDELLHDSLKNDLPIIGEHCVSMDRFEKVVINGSRSYYYYINCYNPLIVGNQTQPKIPVINNTNVDSSPQGDGNNNMAKNNSNQSSLLLYLVFFKTIKDYMENVFTMHTKYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI74</accession>
    <name>A0A0N5CI74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CI74"/>
    <dbReference type="WBParaSite" id="SPAL_0001753300.1">
        <property type="protein sequence ID" value="SPAL_0001753300.1"/>
        <property type="gene ID" value="SPAL_0001753300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001753300.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24856" checksum="7360F39CB95F6127" modified="2015-12-09" version="1">XKDNQCSFWQMIYKEDIATVIAIIYNKNSEENDGISKDLYWKSDKRTYGDITVAHYKKIKVNVLSVTGYQILLERKGGRSKSLKIYHAFNWKENDIPQSDLQFTSIYQEILKVVPKKNILINSSQGTRARIYILTYFACIYDGLKSENESYCPLRIIKSIRDKRYGGNLVSYEFTYIVKALVTTLFNNKILVDFSTRRSDFMSSYDNYFMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CII5</accession>
    <name>A0A0N5CII5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CII5"/>
    <dbReference type="WBParaSite" id="SPAL_0001763900.1">
        <property type="protein sequence ID" value="SPAL_0001763900.1"/>
        <property type="gene ID" value="SPAL_0001763900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001763900.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19967" checksum="DD30929503530ABC" modified="2015-12-09" version="1">MIAGSRWSLEFKPISNDEFTGVNSVQGFINLNQEQTQVNEIYLNMELREKEQNDEKMWSNCLDDLDEISNKTRNKTLNFRGNGSYTRMETLSWKEQIIGENFKQDTERMNYDFQKIDEIDDWSRVLAGKVRDISYRTGTTELDNILSTICCLIEQLNMGEVFAQETQDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIU1</accession>
    <name>A0A0N5CIU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIU1"/>
    <dbReference type="WBParaSite" id="SPAL_0001774600.1">
        <property type="protein sequence ID" value="SPAL_0001774600.1"/>
        <property type="gene ID" value="SPAL_0001774600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001774600.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15146" checksum="CECBFA99819F1EAB" modified="2015-12-09" version="1">MWLTCDNIGLLPASNPSQVTLTPTGATDHDSDAVRELYAFPVNIPRDAVLLFPSQYSAFTCADTRRSRQPLHSYIEVLDTLPSLWQLHSMVRFDGHLPTTSILWGRFFRSSTGGQLKMPIMGSNTHGKPFLSLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B258</accession>
    <name>A0A0N5B258_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Testin</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B258"/>
    <dbReference type="STRING" id="174720.A0A0N5B258"/>
    <dbReference type="WBParaSite" id="SPAL_0000016100.1">
        <property type="protein sequence ID" value="SPAL_0000016100.1"/>
        <property type="gene ID" value="SPAL_0000016100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09341">
        <property type="entry name" value="LIM2_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF22">
        <property type="entry name" value="TESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="163"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="291"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="356"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000016100.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="55456" checksum="ADDBF3AE88B0FF2B" modified="2015-12-09" version="1">MNETQTDILTPYFKRLELKPKHIIAHEYGAGSKCLSCSCPGLDLHFWRKMCKSCNCRMDEHDIVMPLNFDHGAHIRKILIDRSSPQPSRDSENFINLRNKIGTAIFHKNEHSLKTNTTISTPSSSTNYKTSSEILKEPLYGKINKSNNNINGINNLTFKDGYKKSNNSPCINNENDRQVPEYTWLPQGLPEQLIVEYMNSIPENDRPLVGTDGEQVRRTKLAYQLPYHDSDPTACKSLQKEEDIELHRKFVEKIKKNVVGVGEVIDKREFRNCESQKPNDLSCQTNNYQNVDCYNCNNGLHNSNVIIDTSNGPGKDVFHPKCFKCEVCNQLLVDLLYFFHNDKYYCGRHYGEQIYSRCFGCDELIFQNEYTFAEGKNWHIEHFCCFGCDMSLGGYKYCVKDEKPYCIICYMNKFAKRCETCSQKIPPDQERLTHSDLNWHATPQCFKCFTCLKSLKNSPFMLKSNKLFCSGICRNNFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2N7</accession>
    <name>A0A0N5B2N7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2N7"/>
    <dbReference type="STRING" id="174720.A0A0N5B2N7"/>
    <dbReference type="WBParaSite" id="SPAL_0000034200.1">
        <property type="protein sequence ID" value="SPAL_0000034200.1"/>
        <property type="gene ID" value="SPAL_0000034200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000034200.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13934" checksum="81DB031DE8DBBD4F" modified="2015-12-09" version="1">MRRKLSVLKPVLVNKRVPILFHDNAKPHVSKTTVQKLKELKCETLPHPSYSPNLSPTYYHLFKALELHLRQKKFTKSDDLKNNVSEFLDSRDRSFFSNGINKLVSRWQQCADSNGTYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3X0</accession>
    <name>A0A0N5B3X0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3X0"/>
    <dbReference type="WBParaSite" id="SPAL_0000077000.1">
        <property type="protein sequence ID" value="SPAL_0000077000.1"/>
        <property type="gene ID" value="SPAL_0000077000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000077000.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25428" checksum="22BBD898C24F1723" modified="2015-12-09" version="1">MISSQSRENLKEWIIGKISANFDSSLAHVQILRRNIKNVLEKCRSDLNCDLDNKEKKMLQFFCNHLYRSIFLSSEMSAKKCASQLFVDEIESKLCIVGKNFINKRNLVNSKTYAKHVQSNESPQEEEHEVLMEISNEKELQEYIKMKLLPQFVLEMRNKIDGSRVKSITNSFAIIRSPLPGEALINPFGNLLQKLKVSLKKFFSFIYLRTFFFLTFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B691</accession>
    <name>A0A0N5B691_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B691"/>
    <dbReference type="STRING" id="174720.A0A0N5B691"/>
    <dbReference type="WBParaSite" id="SPAL_0000158000.2">
        <property type="protein sequence ID" value="SPAL_0000158000.2"/>
        <property type="gene ID" value="SPAL_0000158000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002863">
        <property type="entry name" value="Pre-mRNA-splicing factor cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003210">
        <property type="entry name" value="RNA helicase aquarius"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="3">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="4">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="331"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="634"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000158000.2"/>
        </source>
    </evidence>
    <sequence length="897" mass="104346" checksum="0C5BFC69AF07C023" modified="2015-12-09" version="1">MMPVLVYDNLKSKTEFYGQSNKGLQILSSKIVHIDKPKVGEKVPSVVKGEIQYVLPDNYTNFNKKKEWDSIRKHDICFLVTVSAKFDKEISLRDESGDVISNDEFREKLFSFFSKSNNFFDMMEVINVRGCEVECFIDKYGEPIEDYEFEDNTKKFDGLKRIIRVIFDSNQFQKDYVKRVNNKVDNDLYTSFNVIIKRDSKSNNFKGVLETIRQLLNTECVVPTWLEELLLGYGDPSSAHYKEIGTAYETLNFNDTFLDSDHVVESFPNNKVIFAENINFNGSFKLTFNDLKLKYDENSEINTNIYVENGPSDKCVLKKHTSKRNKIRFTPSQIEAIKSGMEPGLTMIVGPPGTGKTDVAVHIILNLYHNHPDQRILIVTKSNQALNQMFEKLILLDIDVKHLLRLGHGEEALQTEEDFTRYGRVNYAENMRNELLGKVKVIKDSLKIEGDYEYSCETATQLFKIILTKMWKKFISEANKTENLYESFPFKEYFEKVEKDENITTDSFNFDIASAVWKSISDIFIELSKYRSLELLKNKKDQSEYLMTKEAKIVAMTCTHAALKRKDLVELGFTYDNILMEESAQILEVETFIPLLLQNPVNNSNRLKRWIMIGDHNQLPPIIQNIAFQKYSNMEQSLFTRFVRLGVPLIILDKQGRTRDEILKLYSWRYPNLTSLPHVQNSNLFKVRNPGFVHNFQFIDVPDINGQGEITPKPYFYQNIAEAEYSVTLFKYMRLLGYPAEKITILTTYNGQAHLIRELWKRRCGDSKFYGSPDKIATVDVFQGQQNDYIILSLVRTESVGYLRDVRRFIVAMSRARLGLYVFGKFSLFEQCIELHPIINVFRTKPMSLEIYKDEKYSPTGETKEDGSTNKTTMKNVEEFRSFVDRCYYEKTSKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6N0</accession>
    <name>A0A0N5B6N0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6N0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6N0"/>
    <dbReference type="WBParaSite" id="SPAL_0000171800.1">
        <property type="protein sequence ID" value="SPAL_0000171800.1"/>
        <property type="gene ID" value="SPAL_0000171800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000171800.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44305" checksum="D7BFC41B91D344B4" modified="2015-12-09" version="1">MNYNYGNYSMGGCGNFGPGGYGNAMGGYAGGMGGYGNGMGGYSNGMGGYANGVVQSQYCSPAMGTSTFGASQYAVAPASPVAYLFGTPSLKPCMNTNPMADANALREAMRGFGCDKTAIMQILCTRTNFQRQQIRASFKQMYGKDLIKELKSELSWDFEDLMVALMQSPHEYDATELYKSMEGLGTRENVLIEIMCSRSNYEINQIKAYYRTMFKTELEKDIVGDTSGYFKNFLVALCTGTRDESGYVDYLKAQQAAAMLYRAGEGRLGTDESAFLGILCSQNFAQLKTIFNEYHRLTGHTMAYAIEAEFSGDIKDGLLALYSIIMNRPGFFAIQFENSMKGLGTRDRDLIRLAVTRCEIDMVEIRNEYFRMYGRPLQQRIADDTSGKYKDALLMLVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7C3</accession>
    <name>A0A0N5B7C3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7C3"/>
    <dbReference type="WBParaSite" id="SPAL_0000194900.1">
        <property type="protein sequence ID" value="SPAL_0000194900.1"/>
        <property type="gene ID" value="SPAL_0000194900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000194900.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17630" checksum="0693B10FBBD78B01" modified="2015-12-09" version="1">MVYFNYYIIFAILKVVFLPEASSFFITPSSDIKSIMRLSSDSPSESDSKENNDRIIEIESVRRPISGESKDFKDYEEYFERSTDVYVDDSNNTTEKVDSLINSTTPTFPLTAHIFIDKMLPIFDSSKEKKLTSKDGESSDDGRRKVDVDTSNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B834</accession>
    <name>A0A0N5B834_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B834"/>
    <dbReference type="STRING" id="174720.A0A0N5B834"/>
    <dbReference type="WBParaSite" id="SPAL_0000220700.1">
        <property type="protein sequence ID" value="SPAL_0000220700.1"/>
        <property type="gene ID" value="SPAL_0000220700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="58"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000220700.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23252" checksum="D88D055ECDDAA686" modified="2015-12-09" version="1">MSLLTKLTNNVRNCFNASRKVSEELPKGDKEIILSTYKILLEADPELFSKAWIMSASRSTSIRKSFNLIESNNIHIEVEFAKFSAVIERFFTRIICDEKLATELFETSCINLGKRHVDFVSFGFHSNYWDIFLNCMLDVIADTVVVAFANDAKQQHQVQKSWNKFVGRIVFLMQSGFKQRQLAEKTVDKKNNSNEFNENNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B897</accession>
    <name>A0A0N5B897_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Merozoite surface protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B897"/>
    <dbReference type="WBParaSite" id="SPAL_0000227000.1">
        <property type="protein sequence ID" value="SPAL_0000227000.1"/>
        <property type="gene ID" value="SPAL_0000227000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000227000.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12673" checksum="E6A4E762A7841E3E" modified="2015-12-09" version="1">MFILKNIFLISILVTILAIVIFGEDKNSNTMVQSTHNLGLDKEKTNEIDHEAEKVPHSPTTLPTPNGDVSDESISQEHNTNTTKSNNNNGNHAHLTSISGITFIFCIVVYYFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B990</accession>
    <name>A0A0N5B990_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty-acid and retinol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B990"/>
    <dbReference type="WBParaSite" id="SPAL_0000260550.1">
        <property type="protein sequence ID" value="SPAL_0000260550.1"/>
        <property type="gene ID" value="SPAL_0000260550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894187" evidence="7">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000260550.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26364" checksum="083DC819EAA4E889" modified="2015-12-09" version="1">MLKIIIFCQLFLILPINGELANSKNAIQCTNDVEIQWEKVNITKLISIIPQDIKEVFDNITTENTLYLQNILHTLYRFVTSDNTKVNEKILDKFTHTNVSLVEEFKNLWVRMIGGSNGITKNGNEFLKKLIQFHYTVLEYVTSDKETTIDYKRLREEVYKIAQEYLNLTNNDRNSFSSSFPSLSNFFNNKILLDALREIKPNSSIKDYTNIRNKLINAIIEKKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9T3</accession>
    <name>A0A0N5B9T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9T3"/>
    <dbReference type="WBParaSite" id="SPAL_0000280300.1">
        <property type="protein sequence ID" value="SPAL_0000280300.1"/>
        <property type="gene ID" value="SPAL_0000280300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000280300.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40346" checksum="20970FE64F646C24" modified="2015-12-09" version="1">MLKNSLEEIGELCDILNVIIEECLTTSVIQDCLTNENLMFVDQELGQTCTYFHKNIFNTDYKCMRNIILKKPECYKMIRGRNLPGLNPLIKCKKQTAFYECIHDDIKQSCGEKGLRILDDTIFNYGCKHPKKLLLSKSSKDEPLFSDTGNKHLTFNVAYKIDNSFIITKYGESITKGNKFYYKISNDCTHYNLMKSRSCTYNIIYEWRETIINAKNPMTISVFLFSYEELLNMCDNYANIFLCSGLENILSCTDDSNVRFIRDNLAYSCSPNNISEFLKSFNCVKRIINDNHGNCKKFITGRLLPGEDQRKCKGIVQFYDCISNDVKRTCGENGKQQLWKYLNEYGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9V5</accession>
    <name>A0A0N5B9V5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9V5"/>
    <dbReference type="WBParaSite" id="SPAL_0000282500.1">
        <property type="protein sequence ID" value="SPAL_0000282500.1"/>
        <property type="gene ID" value="SPAL_0000282500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000282500.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16362" checksum="B47C86BB2139C654" modified="2015-12-09" version="1">MLSKSLIAIIFFVLIGTIYSAGIIGILQSTGAKGKLTCKGKPASGVLVKLYDEDDTDFDDLIDKGYTDANGEFFLQGSHKELTPIDPKINIYHKCNDWWFIPFCKKKFTIKIPNDYITQGDNPKNIYAAGTLELSGDFPGQSRDCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA84</accession>
    <name>A0A0N5BA84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA84"/>
    <dbReference type="WBParaSite" id="SPAL_0000295300.1">
        <property type="protein sequence ID" value="SPAL_0000295300.1"/>
        <property type="gene ID" value="SPAL_0000295300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893994" evidence="2">
        <location>
            <begin position="19"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000295300.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40861" checksum="FA86C729291D7212" modified="2015-12-09" version="1">MCLLPLTLLSTCFTLTWSFQLCQVYLGGGKQISLDICKNLDSGDIYSKESVTFIKANFIDDYCQNFTEDVYISESRLLRIKVRKMYLFGNGPAKPSCVPDGAVYLINGLYYLPSKKHNYITNISNAAGSKLAHSICKEYTNFINAKDFRAVSETRDFIRQIYGSDNITGYIVGGKIYIQPCVETPATSVISSKKLNGICYKETPIVIHGSTLMFSSIGIDLESEATTVDCDSIEKNRSGVWENNISLKRIILALSSILILMLILNCILISWCTSKGQEKKAAEIDYNDFLYNLANETIGDQTLKRCSAYSLTAVKVEGTNEKENFKTSNRNTYNSGPIVFTEPAPQPHPFDAFLQCGNETLPSSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAQ1</accession>
    <name>A0A0N5BAQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Dystrophin</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BAQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000311600.1">
        <property type="protein sequence ID" value="SPAL_0000311600.1"/>
        <property type="gene ID" value="SPAL_0000311600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16242">
        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056503">
        <property type="entry name" value="Spectrin_Dys-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23729">
        <property type="entry name" value="Spectrin_Dys-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="137"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="2928"/>
            <end position="2962"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="3182"/>
            <end position="3238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3421"/>
            <end position="3454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3535"/>
            <end position="3575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1001"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1701"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2034"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2480"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2749"/>
            <end position="2801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3365"/>
            <end position="3392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3541"/>
            <end position="3566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311600.1"/>
        </source>
    </evidence>
    <sequence length="3623" mass="420499" checksum="00A5422E420393AF" modified="2015-12-09" version="1">MLFSGGASGSSKPKKEERKEKKAEKNERYDIQEQVFSKWASWLIEDSNVENFKDLGDHKFLIKLGEYISGQSIPTTNHRHQDIDNVFATLIPDLEDKIYLIPINEVVEGVPKTVSSMIWQIIQVYWKKFAPPGMNELKLSEAIKNWCLEACSQYNEITISDFTSSWRDGIALNALIASYDPTLVDMDEIHSMKGDERIENALNIAKYKLNVPKLLTTKDFSSEYLDNRSVVLYLMTLYLCLVKETSDKSNEKTVKQPSEIRKDEIKMISPETVEALQNFNQNIQMTGEEQQQMHQEQINQLSSLIQQTSQSTSKENPEPQPEYTIRSRKSSSSSQKKYEACLEQVLVWLLEAEEELNNMGHVSTTDVEKLKEQFKQHEQFMLSLTQSQDSVGKVLARGQHLSQKLDDEQCTSVISQLLIVNQRWETVREKAMERQTELQSNLNCLQLQQLNEISKWLDDMEGIMEKRQTIGSDIDEIQRQIKDHEDIQEMISVQQTNIEKLSTFVAVIDVDSDSSEEAKYDILEKKLHEVGQRWVTICEWAENRANALDGLVELQTQYRNELEGLGKWLDIKENEIGFLKSTDLLESENDIKEQLLLLQKIETDLEKEHSSFVKLSQLCMELVGKYDKTNASEANKIRNDLDIITSRWDNIVTRLEEHSQNLIKSGKTGEPYLQQLAAENEKNTLDSSLGTTVQFPSMETSYCITTSPSSEKKIQQQTSQSEMEVVDEFVHAVGELNDQIQPLYDWQRTFKMNLAPETLPIMIKVCQKKLNEIKDCEVKVDGLQNKLMTIEEGVLSKENLQIVNDVFDNFMKKWSLIVKKISECLEELTEKNTDLEKSTQIANTLNDWLTKIEGVLREITKISEPDQRINRLKKIADQLDAQEKNLVYLQKTIPNSEKVKKLQYRMISILTSIQKCQQNESKATLNEWVNKMEQNLKGGDIFPGNVELLNEELNRIERLVAEMLETKKRNTDNNELCEKIDKLLKSTDIKKHNIIENISKTQQLNYKYENAIQKSSELKNELDLLKKSNESLSNLEKEFKLLHDKVTTESQTKEEIIEHLNDIVFKVSRSDNPKKEDLCEMLNGMVKNLNESWNVLDLEIDEHLNCLRKEQKKICETELKNLKDLVEKVETCMNASSDASDAEELSEFLDELEHLLEKIEKVSKQLSSVTPSQNCSLKSEIEKFIVHKEAIVASANRRINTLQSAVNTCDKFESDLCKFQNWCTNVGHILSKRVSDDVYASDVPHEYKQIAKEFDDNQKFLKDLDTFIEKSKSQFQSNDRLRVLLEHSSSQLNELRTKFEEFKKPVMFNNSVNRILRRLSDIENTVDGLTCCSINDIDYNLNHCQQLVVELEEINNELVELDSKKQKFVDCDTVSEDEARKLEQKFDHSRSCCKTLIDRCEMADHKLIKCKEYLEKIEFEKKSLNEILSEAENIDVSTANDKIKALLSEAKASINKIDEFHCLIIQNGFKTNINFDDILERYKNIQKSFNAECFEKEKMNNDNWDALLARTMEYRDELDALLNNLNDVDGIDLRKALFNQRELKNSYNDKVTFLMHVKPELSDKLLSEMNEINNRWNSLENRIDIEDSPVPSKILRCNSDSSEDGIVSIAMEYSEPPTLIENNKDLHFNDSEDNVETLTFQEKVSKLNEVFKQAEESLNFQKYPVKDFDDWRERIDVFNKWLDRWNPTVNEVLDEDVHDALDKLDNVVEMSSNIKETLEENEANLQKMLNDWNIYESETKQLCDDVEELKNNEIVNITEARKTQEKLNEFVKKVEDMNTQWFKMQKNLPGNEDGIAEERRIRSIKQDIFDIGEQIKNFIDLEIKNKDGSVERSEKSLKEENSLGTSLHMDVCESDDDESIHTSSHLLLDGSINNLYDNLNSIENYFDEPEVLPFDGESEGYVEANQMTMDISESDDAMKRIKNLKLKLEKRKRQIAERSSALIALKSLIGQTENVITNHLLRVAKTDDGKEKTPDLNELEEEQNECDSALAKSAVLLRQCENKVAPILEQLSEKDKQNIKSQLGRLKQNFTISEEIIRKKKEKLENRLSDENKLFAILETLEFWCEECKAYLAFMPNPLDEEELLKTKNNIEQLSSEYDEKMSTFHSLENLKNRFVALDCVHNDIKHKMRRDVSSIGAKITDLRLNLRASITQLETLLVECREYSIKYGEVKDWLEMVGNNLEDAKTAKIYTPNIHEFLRYHKEDKEVICPKLKTLENKWKDARKKVDETKMANVKINNFDDLQLQYNMVIENLNSFIHLHMQDKEYSPENEDEVYHHQLLSAISEVDENKSLHSNVQPVKSDTTDSHYTPTTPKEEIIVLPMTESSYSSKATESKESYKPKFNFREMAMLDTIMNIRHWINETERDASQTVDITDQIRQKELNDKIQNLIDELKVRQLESFRIFDTSMEQEIKEKAELCQADINRITGQCQRRKAQLREMIDSSRTWDLLRTDIEKWLIEGNDLLNNSPNVNELSDIALKEQLQAVDMVIDQLSEYKNKMKRVNKMSDELLDSYKIDDGHNLSHIISKLNTKWSKFNDNIRVRKAVLEASIRSRNDFQSALDSFEKWLDENEEKVNKLYLETESSQGLKSCVKRKELLKKENDCNIGIQGNQEVIFSLRQIGYKIIGSLDDEKEKGLLREKLEDFEERWQKLLKDHSIVKERLETAQEESEKLTNNLSELLYWIEEKNLILNKEQPIGGELSLVIKQSEVVKNIKKQIEERERKVTDTIELAYSFLMQHNLRPNLYTKSVLDNNNDSIDEKKEFAEREERRIGLKILADCERLKTDWENLKNKCSEWEKVVEEAHLEMQVLDRAMAESLLAISAIETEIKKRKPVYDLRLEQLKDGLIDNGILKRQIQEASIHIDDMNDAGGRIQASDIVITSGLRSQINAVNERYTILKRDISIRQAALERAFEDFGPSSEHFLIESCQAPWQRAISKCNQLPYYINHDTEVTQWDHPVMVDIMEQVQTFNQVKFSAYRTAMKLRALQKRLCLDLIDMKQLDKAFEKIASTDIGEACGVELMVTSLVLIFEELAKEYPDKIRNVPMAVDLTINLMLNIFDGCRDGFMRLISFKITLIIFCKASLEDKYKYLFSLITTPNGVDPKRLAVLFHDLIHIPKYLGEAAAFGGSNIEPSVRSCFEHNKFPHTLNIDNFMQWLKKEPQSLVWLPVMHRLTSAEYAKHQAKCNVCKMFPIIGLRYRCLHCFNFDMCQNCFFSQRTAKNHKLVHPMQEYCVPTTSGDDVRDFGFMMRNKIKALKPKVGYLPVNTVDEGKPIENRQVIPNNPMTENIHHRMYNFAQKLSKNDEPMVDEIEYSTEKKNSSTNEDEYIGMDDSVVLNWKRETERKTEDVKSPIQLINQVDQMHKEELDQVLHKLQLENIELKRELEKKRQISNLRSTPNINQLGRGTYGSSCKQYNTFGRYESSKRNDKNLSNGSLPPMVPLHQSRGSYDGYGNNMKRAGSVVTQGSYISSQKINKHGSLQNIDPVNMTDEQALVEEARTLRLHKHRLEQRSKVLEEQNKQLETQLERIRKMISSRKSSEPQMRSPSTFDNIQSPYENRDNNALTTDDEESCDNGLRKNRMEALIGTCDELGRAMQNLVYNVVATEATDDDIDENDDIINGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBL2</accession>
    <name>A0A0N5BBL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBL2"/>
    <dbReference type="WBParaSite" id="SPAL_0000341825.1">
        <property type="protein sequence ID" value="SPAL_0000341825.1"/>
        <property type="gene ID" value="SPAL_0000341825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894046" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000341825.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9753" checksum="3BFF259688148F04" modified="2015-12-09" version="1">MNYKVIIFLFLTFIQNSVERKKFTRFQVVGATGRLFCGKHASPRTQVLLTDHLSYGLKILSRIHSNTDGIFYVSGSERKVFPISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBQ5</accession>
    <name>A0A0N5BBQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BBQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000346100.1">
        <property type="protein sequence ID" value="SPAL_0000346100.1"/>
        <property type="gene ID" value="SPAL_0000346100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="7">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="504"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000346100.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="81522" checksum="BF147B593F417B67" modified="2015-12-09" version="1">XQALVALLETKFAELEYTEEQLDQWTQENLYLSESGDNRRTVKLEEFLSKEIEKRKIDDLSSSFELSFRHTEEESGKVIKTEIVDEEEEDMSKAWMEIDKFEASSGKSIKPMLERLKIAFEVDGTNVDRMKINLLKLKVCDDTLKFIDNLEEDKKNTFDDLAAELLNKYEGKVQLTTAMLMLRHFRIKNNPTTFRKECEEFGKLLDQCYNLKESEKIARLMSIVESDCVFNKLVQDFDKYSSYSEAVLQCECILKADANRKNSRSERKTFAGVCHHCQIKGHKSDECKFKKKGLPVGNYNKKKEKEVKKEDINNVVKSDERKQTDNLLLVDVKLNDKKIKALLDTGATKSIICNKVARDLNLKIDKNRSLNIATLGEKNLKMWKSQKSVNIKFKGYSFTKYILISDSEFSLDREYQLIIGNDILKDIPHFNELKKLSWDEANVLVVKNELDQKNELIENLKRKFKDVFSKSDYDVGNAELYMAPVELNGQNFEKPLYYPIQEALKDQSNQLIDELTSSGILIIPDENTDVEFISPTIVLSKGERKVRLVCDLRKLNKCVKRRHFPMPLLKHLLGRCSGMRWFTKLDQNSAFWQIGIRKCDQKYFGIYTSRGIRIMTRMPQGYVNSSAEYQAKISNLLKSIEGVVNFIDDILIVSSGTLAEHIKIIESVLEKFRSVGMKICFQKCNFAGSACNFLGFEIDQYITKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC75</accession>
    <name>A0A0N5BC75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC75"/>
    <dbReference type="WBParaSite" id="SPAL_0000362200.1">
        <property type="protein sequence ID" value="SPAL_0000362200.1"/>
        <property type="gene ID" value="SPAL_0000362200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000362200.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16405" checksum="D4468A4ADD127B36" modified="2015-12-09" version="1">MPSTYISCNIEQCDLGLVFFDKYKNIEILNNVNKIHDVEHAVLMIIKSIDNKMLLDTKSHHKVNIRLSICPYINWVHKNRLLKFIPEDHIKDNEFFEEENEYAHIVVPLYKINYNSEEFTCGKLKQPTLPDLIVGFKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCR1</accession>
    <name>A0A0N5BCR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase PIF1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCR1"/>
    <dbReference type="STRING" id="174720.A0A0N5BCR1"/>
    <dbReference type="WBParaSite" id="SPAL_0000380600.1">
        <property type="protein sequence ID" value="SPAL_0000380600.1"/>
        <property type="gene ID" value="SPAL_0000380600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000380600.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11691" checksum="C103D3571462C552" modified="2015-12-09" version="1">MIYEGSCSFPNETRKMLKCKSLDGSKTYYIPQIVHDPVDLNIAIPFSRYQFPVKLGYCMTINKSQGQTLDKVGLLIDEMVIFSHGQLYVALSRVKTPNAIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD63</accession>
    <name>A0A0N5BD63_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD63"/>
    <dbReference type="STRING" id="174720.A0A0N5BD63"/>
    <dbReference type="WBParaSite" id="SPAL_0000395300.1">
        <property type="protein sequence ID" value="SPAL_0000395300.1"/>
        <property type="gene ID" value="SPAL_0000395300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="221"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000395300.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56979" checksum="DABEEF78AFCE96C3" modified="2015-12-09" version="1">MKLKKKDISSPEAFQHRIHAEYDKNTCTFKGLPKQWEAILGMNTYIGKSRPKPIDPSKFTPHQMAQYKKIVRGTTGTGYSSRPESTMSKWNASDMFNSDFSNRSTPLSIVQQTNLSISSYPSTPPIYSKIKKSDSFRMTPIINNVESNCDFNNDTQKIIVKNRPTLIDNYNYNDDNNKKEDTEAVKKDISKVQSESQGLSDENFRMALQCVVDCGDPRSNLKSFVKIGEGSTSLVVRAILTTNNTSVAIKRMKLKGQQRRELLFNEVVLMKDLKHSNIVSMYNSYLVEDELWVIMEYMESGPLTDVVTEMRIEESVIAYVTYQTLLGLDYLHRNNIIHRDIKSDSILFSKDGTVKISDFGFCAHLTDDKPKRRSLVGTPYWMAPEVIKRSSYDVSADIWSLGIMIIEMVMGEPPHFHEDTIKALKKILECDEPTIPSNANVSEELRDFVSKCCVKKSDLRLSASKLLEHPFLKKRCDNQYVINLLKKLSLEKNESHKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDG2</accession>
    <name>A0A0N5BDG2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEST proteolytic signal-containing nuclear protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDG2"/>
    <dbReference type="WBParaSite" id="SPAL_0000404800.1">
        <property type="protein sequence ID" value="SPAL_0000404800.1"/>
        <property type="gene ID" value="SPAL_0000404800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000404800.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10021" checksum="45B9172CC251C259" modified="2015-12-09" version="1">MTEKKPRMSICAVEGAPPPATITLPSPTNISSANESQPEKKKNIFGKLFNKSTKEEKSSSIMGRGNNVNPVITDTGMSRKDTVTSMTESEGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE02</accession>
    <name>A0A0N5BE02_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE02"/>
    <dbReference type="STRING" id="174720.A0A0N5BE02"/>
    <dbReference type="WBParaSite" id="SPAL_0000422900.1">
        <property type="protein sequence ID" value="SPAL_0000422900.1"/>
        <property type="gene ID" value="SPAL_0000422900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF25">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="NTR" evidence="6">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000422900.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16166" checksum="88CFA8D18A06328B" modified="2015-12-09" version="1">MICLNFNHLTEGCDCMINGGENDYCFSDWISHVKILSKDVAMVDGTDEYAQEPEGVKYTVNHLQVFKKPSNMTDESLSTLITTPSNTAMCGVDFLNVSDSYILSGAFNSDHTLSIYLCGGLKYNYDKVDSIRKLMKYKNEMNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEA4</accession>
    <name>A0A0N5BEA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEA4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000432700.1">
        <property type="protein sequence ID" value="SPAL_0000432700.1"/>
        <property type="gene ID" value="SPAL_0000432700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894243" evidence="11">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="144"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="242"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000432700.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37676" checksum="6435A661034FE0BF" modified="2015-12-09" version="1">MKFWYFIFFIFLSSVIENNCLQNDGTDRNITSDAALLKTKKIHGRWYFGGIASCGAALLSHPLEVVKVHLQTQNRYDPDSKSFLKIIGHIFTVHGILGFYAGISGSLLRQITYSTARFAFYEFFKSTFLYLNNEDPDNDVPFDYKVILASFAGAISGFIGTPGDLVNVRMQNDIKVCDEHRRNYKHAFDAIYIIIRDEGFITLFNGATMAICRAIAITIGQIAFYDQFKYIIISTSFLNLKDGFITHLISSIGASSTGTLLTQPIDVIKTRMMNAQVGEYGTVTEYIIKIWKSGPLNFYNGFIPAWIRLAPHTTFMFLIYEQLKINFGYTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEK4</accession>
    <name>A0A0N5BEK4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEK4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEK4"/>
    <dbReference type="WBParaSite" id="SPAL_0000443000.1">
        <property type="protein sequence ID" value="SPAL_0000443000.1"/>
        <property type="gene ID" value="SPAL_0000443000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000051">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000443000.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12689" checksum="EB46EEF9C9792A8D" modified="2015-12-09" version="1">MLLFCPECGTLLKVTEHKSHGCNILKCINCSYWQNIPGKIRSKYYPQLKDMDEVLGGPSSWDNAQVTDEKCPKCGGQRAYFMQLQTRSADEPMTIFYRCAANECCHRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BES1</accession>
    <name>A0A0N5BES1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BES1"/>
    <dbReference type="STRING" id="174720.A0A0N5BES1"/>
    <dbReference type="WBParaSite" id="SPAL_0000449300.1">
        <property type="protein sequence ID" value="SPAL_0000449300.1"/>
        <property type="gene ID" value="SPAL_0000449300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="421"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000449300.1"/>
        </source>
    </evidence>
    <sequence length="757" mass="86920" checksum="C272E4E7D96AD272" modified="2015-12-09" version="1">MGIFQYKRVPMGLVGSPDFFNHVMEKVFSDENNFVYLDDILLTDNTITAHLDNIENALEKANTLGLRFSLSKCLFFQQSLEYLGFIISSKGVEPNPTKTSALNEKDIPKNERELRSFLGAANYYRKHIPNYSKIAHILYDATNNFIWTSKHTIAFNNLKKAIIEACTLAPPNLAEDFTILTDASIQGLGAALIQQGRPIAFASRTLKKSEAMYAPVQLEALGLVFALKQFSPYIYGKRTTVLTDQSSLISLMEKRDVSNILDRYKNYIMGFDLNIKYIKGSDNTVADYLSRKVFSINLTSTTDDFADVFPKVQNYFQYPFIIKNFNKYLSDKEKETYPNCTITMRGKVRIYVPQKLRFMTLTLWHEHPLLGNHTGFDKGSLKFKDTFHWPAIDNDIRRIWSSCQQCIQNKPHGPLQATVNVKTLPIPPHPWHTLSLDHLVINENSYVLVLIDEFSKFVRLHHVTNMGALTTIRELTNTFFLLGFPNTLKTDNGPAFIADTFKSFCKTFDITHYQVSAYNHQGNAIVERFNRTIRESIRLYNNNNILDIINSIQYVHNFSYMTNQDGKPKEYILSTIDRYTNENYTNIELSGRRSLLDYIKTHLHKSDKTTPPNEFKIIPRDTIVFKKNVSAHKNDKQFLGPFKIVEHLHGDTYMIVKITNSKRPTGLPEKVNARILKLAPKIIQEQSQHLENTSSSTTDTTETPINIQIPIINEDNQPKRSRGRPKKITAPSKINENIVSDKPLLKRGRGRPRKNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFF8</accession>
    <name>A0A0N5BFF8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable DNA-directed RNA polymerase II subunit RPB11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit J</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BFF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000472400.1">
        <property type="protein sequence ID" value="SPAL_0000472400.1"/>
        <property type="gene ID" value="SPAL_0000472400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="10">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000472400.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14051" checksum="982772D704CFAD6D" modified="2015-12-09" version="1">MNAPAPFESFLMLDGEKKISFEKDTKVPNAAIFEIVKEDHTLGNLLKHQLLKDPNVLFAGYRNPHPLEHKFHLRIQTTPDTTPTQVLLDAISDLIAELSMTEQYFKESVKDRRETSDIQHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFV1</accession>
    <name>A0A0N5BFV1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFV1"/>
    <dbReference type="STRING" id="174720.A0A0N5BFV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000486300.1">
        <property type="protein sequence ID" value="SPAL_0000486300.1"/>
        <property type="gene ID" value="SPAL_0000486300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="67"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000486300.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="60733" checksum="4342CA1835135FF1" modified="2015-12-09" version="1">MGRFNVGLLRYLQPDDFRVLLAVEMGLKNHEFVPLPLIATVAGIHRGATSRTLMELCKYQLVSYECGKSFDGYRLTNLGYDFLALRALRSRETVSAVGNQIGVGKESDIYIGGDKDLNDVVLKFHRLGRTSFRKIKDKRDYHNKRHHASWLYLSRLSALKEFTFLGALYTRKFPVPKPIDCCRHLVVMGLVDGVTLADVSELNDPGALYDKLMNLIVRLARHGLIHGDFNEFNLMMKKNEEPVMIDFPQMISIDHPNAEYYFMRDVNCIRDFFKRRFNYESELAPSMKDIERIHNLDAELSASGFTKQMRRDLNKAYEVGDFKAHESDCSESDIDGDKEEEEEDVEEIDTDEYDDDIHNREKTDKELRFDKWIQNTQNNFDKLCIEENIENKNNGLEEMSNEQMEKYKKAIDDAKQRMEEVNENEKVNQPPEYDSEEDDEVDDMGGDAESDNQRRFRRGKVTQARSVYSNGSTIAPEIVRKRLLHEKRHAKKEKIRVKGKQSAISRNRKANKELIKEYSGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFX2</accession>
    <name>A0A0N5BFX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFX2"/>
    <dbReference type="STRING" id="174720.A0A0N5BFX2"/>
    <dbReference type="WBParaSite" id="SPAL_0000488200.1">
        <property type="protein sequence ID" value="SPAL_0000488200.1"/>
        <property type="gene ID" value="SPAL_0000488200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="389"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="487"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="580"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000488200.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="81892" checksum="886D2AC5B409227A" modified="2015-12-09" version="1">MAQNLFKQPSTCRYGDNNYSTLINQYIEGERKSKIDLEKKSLPSRMWEKYGPLRSARCNVDYSSVVSHTIQRANREQLRKIFNKYASIEKGNEKYMTDDDFIRKYLNLYMDNDYNKKTVRLLASAVNTSKTNLISFEEFCSFEATLCKPDALYLTAFQIFDNNSNESISCSDFERIIRHTTPLLEVDFDFNSDFIKRYFGQDKKRTLGYYAFCELLHDFYEEQGKQAFNIYDKKKEGAISAGDFSRIMTQIKGHLLTEFVRNNLMAVASGNNSSHKIRYPFYAAFNSLLSKMELIKRIYLSLARGNLNLEVTKEEFLQAAQSFAHVTPYEVEILFKLAEVAHPESRSLCFNDIEKIDPERLKRVTYISRLATYSAVNEKKERSTSTAILESLYRFVMGSVAGACGATAVYPIDLVKTRMQNQRTSSVIGEVAYKNSLDCFKKVVKFEGVLGLYRGLLPQLVGVAPEKAIKLTVNDLVRDKFTDNGKISLIGEIIAGGCGGGCQVIFTNPLEIVKIRLQVAGELQNAGKHINVFTVLKDLGFLGLYKGARACFLRDIPFSAIYFPAYAHAKLATVDEDGHNSLPSLFASAFIAGVPAAALVTPADVIKTRLQVSARAGQTTYNGIFDCAKKIMKEEGPTAFWKGTAARVFRSSPQFGVTLLTYELLQRVFYVDFGGNRPTGSEVAVNKTRSDIKSDNPDHIGGYKLASATFSAIEHKFGLFLPKFEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGT6</accession>
    <name>A0A0N5BGT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BGT6"/>
    <dbReference type="WBParaSite" id="SPAL_0000518600.1">
        <property type="protein sequence ID" value="SPAL_0000518600.1"/>
        <property type="gene ID" value="SPAL_0000518600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000518600.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42626" checksum="A671D531BA71DD45" modified="2015-12-09" version="1">MTTDLLKTYFCFRDRNIKMSLPPEEEFLCPSCNNIFYSIDYLIAHLEESLRFNDDTHKQTVKCLFCDVYCNGSQSILHHLYTEHIQEWPTSSKNDVLLEPIAEVTSTTPTIKEGTVSKRVIKNERKHGCGFCEKKFTRPADVRRHERIHTGERPYACRECDSSFKTRHQLTQHYAIHDNALPSEFICEVCKKAYFTKGALTLHLRTHNNTNPFSCSYPGCSQAFHTNQLLKRHIKRSHPQKQVIDKKGILKTIEKISPSKTNHQIIKQSENSAFDLQIPEPPPYEHHISYPTQIVVTDPSETVSCVDPVIIYESVDSISGNIESTTIIPTQMYQTVEPIYHEMMPSYPQSVYHTEESWDYSTEYPRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH73</accession>
    <name>A0A0N5BH73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrotrans_gag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH73"/>
    <dbReference type="STRING" id="174720.A0A0N5BH73"/>
    <dbReference type="WBParaSite" id="SPAL_0000531700.1">
        <property type="protein sequence ID" value="SPAL_0000531700.1"/>
        <property type="gene ID" value="SPAL_0000531700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000531700.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30230" checksum="6C87D75B2682F5F4" modified="2015-12-09" version="1">MDFGAKLIALAMSKGYNMEVPPIESIKTESADAQQRGMFLADIYILAEHMPLIFTLAYKYGCLKRRMKDGTKCSGKEKVDLPVLQPYDDKNPREFLEKFEMRYGGLETTSQHQLFKEYLSGGALIAYKALKIEDYNNFKEFADAWIENYKPNFSNKRREIILEQLLINNSRKADSPIQYINRLQGWINELSELRHLPDSEIAKYWLAAAKGLKRYDEIFDYYCSSNRENSLLKAKVLAALEKETQRDPTYKKENTGPSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIU0</accession>
    <name>A0A0N5BIU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIU0"/>
    <dbReference type="WBParaSite" id="SPAL_0000587000.1">
        <property type="protein sequence ID" value="SPAL_0000587000.1"/>
        <property type="gene ID" value="SPAL_0000587000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000587000.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19528" checksum="17B96DD25F03DCB2" modified="2015-12-09" version="1">MIFFNRIKQYILFIFCILIIEFVKFSLSSESEKLPEKDRKNSETKRHSQLGVKLRKNSKKEGQTPKSREKRLEGLRKQLNVGDHAPISRPLSEIRVPERKTKSRNSQHNSNKLRRRPSQTKDNQNLHGQRRHSNPITGQLTLPRQNKQGSQPFRRSKSCRGYFCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIU5</accession>
    <name>A0A0N5BIU5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIU5"/>
    <dbReference type="STRING" id="174720.A0A0N5BIU5"/>
    <dbReference type="ESTHER" id="strea-a0a0n5biu5">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000587500.1">
        <property type="protein sequence ID" value="SPAL_0000587500.1"/>
        <property type="gene ID" value="SPAL_0000587500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012249526" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="21"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000587500.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="67255" checksum="0A186645BEAD454D" modified="2015-12-09" version="1">MLIFILLFSITKTLCYSGPNITFGNSTLQGTNITVLNDSMTEYLGVPYARPPIAYYRFEPPIELNDTLYWNGTYPAIHLADACPQIIRMMNFSGYDDANPKNTSESCLKFNMWVPKANDDEKMPVIVFFHGGSWTVRTASVDKFNGSVLALKTKSIVIAANFRLGFLGFAYLEGSSQIRGNMGLLDQQAMLKWINKNIDKFGGDKTNVTIFGTSSGASSVAAHLFSNGSKPYFNRGIMSSGTITHFMSTVSTKIADTNTRNVSRLVNCTQHTNGTNFTVEEIATCLKNITNVTLLLEAARTVKADGQFPTPFPFMPIDNDTVFFNGSIKKMYSEGSFNKEVDLMMGRTGDEATFFMATGFTNNSRYNCRFYPQKNATDPDNACNMNETNFVNLVSFGSTILHFNETENNTLIQIYNNSAATYTNRSIRILSDFIFDCELSRFANIYANGTNKNVYLYEYARRSPINIWPNWTGAMHGDDLIDIFGIPFRHPEKYKINDEKEEQKLSEQVMWTIGNFSKYGNTTSKWEKTKPSNLTAFIFNGTDSFNSPTNKNFTPPTCIEFSKLMQNYMTRIKKMIEEMKKKKEEDKEKEKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ73</accession>
    <name>A0A0N5BJ73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ73"/>
    <dbReference type="WBParaSite" id="SPAL_0000599800.1">
        <property type="protein sequence ID" value="SPAL_0000599800.1"/>
        <property type="gene ID" value="SPAL_0000599800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058430">
        <property type="entry name" value="DUF8117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26431">
        <property type="entry name" value="DUF8117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8117" evidence="1">
        <location>
            <begin position="48"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000599800.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="36177" checksum="6A7F59D21A7B7BCF" modified="2015-12-09" version="1">MTTNIKKLPILSMEDEELFPKDKVFDVPQAIASFDIKLFVELNNISTPLWWSRLIISSRGYLANYIEMDEEKLFLTDDAFILLHKVFVEKNHTFTSLEFIKALLHLFRIPRMSDGFCYTLQDDFEDEILNDDKVDEESSLEKYNVIKDRITISPCEVLFGKNGVLSIKMAEIQKEGYLMFMKILSILILRFKEDMEQGKKKGIRFDIDNEWQPDDRVVLFQQFYSGNRTWILTDFDRHIMLYWKPKGANVIFGDAYIDKKKRSGFMLCEYCGMLEQSVNQFPQFRNMKFCTEQCLNKLLDEKNITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJE9</accession>
    <name>A0A0N5BJE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJE9"/>
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    <dbReference type="WBParaSite" id="SPAL_0000607500.1">
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        <property type="gene ID" value="SPAL_0000607500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894355" evidence="2">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000607500.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35991" checksum="7BBF39FB0DB5CCCA" modified="2015-12-09" version="1">MIRILSLIILLFQFVCIVEGSCNYYQYYNLLGVLTNEKVEAHACKDFFETCTYVSLVIPGLVEGSFSGCPSETNSILTKIMKERLDIFNQFKVFINNATGLIDHELLCQHSIDDNKPLLIATMSGLGKLFVHCYGQDTTYNTPGVKYNPPTTVVIPANCNTDQGQAICTEGYCGMLELSSITPDGQSQVSKKYQYCPNNIINQLYLISTQYNNTFNQALISDIYSIGPVCVNELNFQMLSKNSSLSYFWYVNCYVPNNTVSVQFPAIPNLFANDTTTTTLNPIMTTTTSNPIMTTTKVTIPSSDFSFITITLFLLINFILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKG1</accession>
    <name>A0A0N5BKG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKG1"/>
    <dbReference type="STRING" id="174720.A0A0N5BKG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000641800.1">
        <property type="protein sequence ID" value="SPAL_0000641800.1"/>
        <property type="gene ID" value="SPAL_0000641800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF31">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE ASM-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894658" evidence="4">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000641800.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23465" checksum="9EB89CEEC42293C9" modified="2015-12-09" version="1">MNLKIFVILISIITTIRAESEACSACHTIVTLLHQIWGSSTVDDCLADALTFVCDKLKIEDNFVCKGIIGDFKDEFFYVAGKLIVNPEEMCSLLIQDCGTPILELGSNWTIPIHGNKPPVTVPNLPDPSKPKLKVLHISDIHIDSQYLPGSEAECSEPECCRPPKDQEEIVLGNVNVSAPKWGHIGHCDIPYATLENMLQHISKTHSDIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLD4</accession>
    <name>A0A0N5BLD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000673250.1">
        <property type="protein sequence ID" value="SPAL_0000673250.1"/>
        <property type="gene ID" value="SPAL_0000673250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000673250.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11186" checksum="540BED71AA345073" modified="2015-12-09" version="1">MDLSDPKVTEKYSQKIGEFVNKIMAKFKDGKPIDGLLLLHADYKELYDQVDFKFMLKIIIFIELQTRAFYPANNFLLLIGLNRFKSIKYITVTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLL7</accession>
    <name>A0A0N5BLL7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BLL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000681300.1">
        <property type="protein sequence ID" value="SPAL_0000681300.1"/>
        <property type="gene ID" value="SPAL_0000681300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000681300.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49058" checksum="62F425733D4BC564" modified="2015-12-09" version="1">MMGSGSSKPPPQIIAKSSGPVYAIKTIGSRHFIIGGGGGAAKTGVPNEIELFLMSYNNFCKLDRNEKDSSNLMQAKKTASFETNPHATMNMDVLNIGEIGECKYLIAAGHDEYCNLYETTNFDLAEGCEDDIDDPSRLKFNFKHVVKFITDKKEDGGYQKTVRFDKSGNNINKFRMATGGGDGSIRIWNVTEFLNDRNPVNKKNPILIFNNAHEGDVDDIDICGNGRHLLSIGSDCKTILWDIEQGRKVSEISLPKSMIGIFKIRSGRFVNFSKSGGNVLFVTAINQIKQTRKRICYLALWVFLIEKKEARIITMKEIGKESISTLAISSCGNFTAIGTIEGSVGIYNTHTMDQLYFAPSTHKIFVTGVEFLPNKSYDTLGRLPGVALNNKTSVLSLSADQTIQLHYVPFTKPPSTSRFLVALSFSLLIFYFILSWLMNIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM88</accession>
    <name>A0A0N5BM88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM88"/>
    <dbReference type="STRING" id="174720.A0A0N5BM88"/>
    <dbReference type="WBParaSite" id="SPAL_0000702900.1">
        <property type="protein sequence ID" value="SPAL_0000702900.1"/>
        <property type="gene ID" value="SPAL_0000702900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005863">
        <property type="term" value="C:striated muscle myosin thick filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060972">
        <property type="term" value="P:left/right pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="86"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="859"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000702900.1"/>
        </source>
    </evidence>
    <sequence length="1247" mass="145578" checksum="E17340CF06D823C8" modified="2015-12-09" version="1">MVVQLEWLTDPGWPYLRQMPDEALKEQAARKFDNKTHTWIPDPDEGFLIVEVMVAEGQTFSVKLPNGQTRKITKDQCQEINPSKFEKTEDMANLTFLNEASVLHNLRQRYKSMMIYTYSGLFCVFINPYKMLPIYTDSVIEMYNNQRRSEMPPHLFAVSDEAYRNMVTDKKNQSMLITGESGAGKTENTKKVISYFAKIGGSNESKVNPLKKAVSFSDFPVGGSLEDKVVQANPAIEAFGNGKTNRNNNSSRYGKFIRIHFDKSGKLVGGDIESYLLEKSRVIKQGPGERSFHIFYQIMTNKKLRKEYLLSNNIKDYHFVSQAEITVPGMNDTEEMSITDNAFNVMGFTGPEKNDLYKLCGAIMHMGEMKFKQKPREEQAEVDSMNAIDNVCKLFSINGEKFVQALLKPQVKVGTEWVCRGQNLQQVEWSVQALAKAIYSRMFKWLIDRCNETLSTNLDESVNYIGVLDIAGFEIFDTNSFEQLWINFVNEKLQQFFNHHMFILEQEEYQREGIVWEFIDFGLDLQNCIDLIEKPLGIISMLDEECIVPKATDMTYAEKLKNQHLGKHTNFQTAKPPRGKQGEAHFAIVHYAGTVRYNVIGWLEKNKDPLNDSAVAVLKTSDKKNLIYKIFEDYQTETDREEAHTRGKELARKKGKSASFMTVSNIYKESLNNLMSMLHTTHPHFIRCIIPNEVKMSGEIDAQLVLNQLTCNGVLEGIRICRKGFPNRMVFSDFRYRYAILAADESRLPDIRDACIKMMDKLLKSKKISEDEFRVGETKVFFKAGILAKMEEYRDAALSNIILKFQCQARFYLAQIELKERERKINAIIDLQRNIRTWIKIGNWSWYKLYIRLKPLMGGFKTKEEMEALEKKIKEMEEMLAAANEENQKIKAIQNESVKREEELKTNIKNEQKEKEMFDKKLKEYEEALEKEKQINIEREKKNLERESRMENERKRLEEEIFRQKQEMETMTMKHTIQIEELAQKLLLQGDISEQMNQQRKIQEQAKLDLMDQLERMGSKVERIEKQRLATLEELSKYEEKVNYEKKLKEEQIKLRKKLENEMKQLIDKIELLENKNDALEKELRDKHEESIRLKDKNFSEISLISKMQVNIRQLIERIGQIEDELDIETRARSRAEKSKAELQRELDEALQTITELTGQLNAQMHINKNKQHELAGLQREMDKRHIGFETHLSDLCSMQMSTLNNLRRLSTQAKCLEHETNLVLECRKPCEIKRSYSLTSYDDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM89</accession>
    <name>A0A0N5BM89_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM89"/>
    <dbReference type="WBParaSite" id="SPAL_0000702950.1">
        <property type="protein sequence ID" value="SPAL_0000702950.1"/>
        <property type="gene ID" value="SPAL_0000702950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894607" evidence="2">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000702950.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="52176" checksum="8C65103A5AE2F374" modified="2015-12-09" version="1">MEIFHFVFYFSYIGFILSFIPSKIPDCSLESPNIEYIYTDKFNDYIYLNQTWEVKIGERYFFKDHECLSTKHYVLVSKFFIIDLYSFEIWLKTKSVGGELCGYMSIKVHDGSYFSFYSITQGTINDVYESLKIDKKYDEAIKSFVIGTNFKNFIRREGKLKREEWLSLLNYLNIYYKSEIYNGNGTIYCYKKEKEHCFLKDTLIEYTPSWFSKMYIDLFGYEYYIYGEPEELLDLVARQINQIGNEIFKQNNYTLNKDIGEYIIDENDNNKKYFQVNEKIIVDPIFNGFKVKNCTLVYIKQVMNKLNKCGEKLMVNTNYGVRFYDVNLQTLILPEDLEHCDNKLEYMSLKKNDITNLEDISIFDQVKFQIANMNTLTIISFILFIILFLIFVSIILIIKRKYSFDQKKKLSFNITLEDDVIIEDYPNKAVKISKEILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMI9</accession>
    <name>A0A0N5BMI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMI9"/>
    <dbReference type="STRING" id="174720.A0A0N5BMI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000712500.1">
        <property type="protein sequence ID" value="SPAL_0000712500.1"/>
        <property type="gene ID" value="SPAL_0000712500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000712500.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27997" checksum="F623CDA76448AD29" modified="2015-12-09" version="1">MERYGLVSSLVIIPIITNGLVVKIISILTFQHNNHPPPYQIPEFILTLIKINGKKSLCSNGFLYYLYTSFWNKTWNEYKNGFGNGETNFWLGNELISLFTNSFEKVEMLIQIRGDRLDKVDPMASSNYWSGTFTFNLLPEYTDYTIQLSNATGNATGNGWDDFSYSNGWKFSTIDKINSPYPPCLTQFHMGGWWYNYCGFGSLNGQYNPPIAEDRGYGFSWSITEPTRIVNPVKSRITIREITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNA9</accession>
    <name>A0A0N5BNA9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="4">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNA9"/>
    <dbReference type="WBParaSite" id="SPAL_0000738800.1">
        <property type="protein sequence ID" value="SPAL_0000738800.1"/>
        <property type="gene ID" value="SPAL_0000738800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000007">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF634">
        <property type="entry name" value="DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="23">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="570"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000738800.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="96973" checksum="0B370B72EC110A3D" modified="2015-12-09" version="1">MLILNFSSTYSHQYNSQSMIFLLMSLLISIINGLELRECNKALGMENGRIKDSQITSSSSYDEQSTGPQHSRIRTETGAGAWCPMSQINMSSNEWIEIDFPTNMVITAIETQGRFGGGEGQEYTPMFKIRYKREGMGPWARYKDSSNNEFIKANSDTRTSVLIPLDGSIIASRIRLYPLSYKTRTVCLRLELHGCRYNGVLDGYTITNGGIIDGLEMRDFKFDGNTNDTIKTKGYGKLYDGKIGEDNFDDKPNHWIGWKNEDVKGKVTMKFYFKDKQNLTGVNFYTNNFFKLKSMIFKKAIIKISPTGDEKTFSKRSIEFSYEPDLIYPSSRWVRIPISSRIAKLIKVDLYLQSAADFLLISEVKFETNRILFDTDIDDPLLSSENDDIISLDETKNSLTFFAINEVPDNLTNYVLIVVIIFISLSLLICSTLIYVMFFCRKEAQQKNTLLPIFKKQNVQMIIKDDSDTIKRSFKSGTLMESKNIPSDSSSDYADPDYSVCVEQPLLNRMYYSTECGTYNIFSQGTLTSNLSNTSSTISSPNTCYRNCNKEIEEFLFNMDHIVKINPSVLIHVEKLGDGEFGPIDLCRLEHRLVASKKLKQTATKDEFINFKKEIIVMSSLKHQNILEVIGISIEQPNNTICCIMEYMKNGDLCQYLQSQNFNTLTTEFLLSIATQIAAGMSYLESQNFVHRDLAARNCFVDEDDIVKIGNFGMARSLYSSDYYVVEGKVNAPIRWMAWESLLLGRFTTKSDVWHFGVTLWEILMGGYDKPYSKLTDNEVIENLECIYNSGRLRTYLPRPRHGNSILYDELMLKCWQREEHNRPTFSSIHCFLQKMTCNHARGSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNQ5</accession>
    <name>A0A0N5BNQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000753200.1">
        <property type="protein sequence ID" value="SPAL_0000753200.1"/>
        <property type="gene ID" value="SPAL_0000753200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000753200.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55896" checksum="5CDD3E436C086A71" modified="2015-12-09" version="1">MTRKWSIKSRTSSLIPKPLRNSTIQKIIAKSITYIVLSKKRKKGKKTESECIFDTDEAYFSQSAEDTKILSHADEMSSDNIAKDVQELKKPITLHKSVSKCQAKEERIKNIYYFVIFQHGNIIKDYQEKSSSMYETNKKIVSVEIGKNEKENLKCFFEYINEFKEYICSGMSTKIKKSSLISLLNVNNNYPEYYIDYDEYIKHLNIQINYKENLIFLNCSLELSSQNKIDSLDTKISSEYFIDVEEIKNESSSDIQIGPLVVSVDNTLYDINNNNLCLSQNEHIGCLPVSQSTIHDIISEDKIESLSHKSIEIERKKNMHNESVNINFDRNTEQLDNINNIDETNFPQLISKTPILESVFKYIHGISSPPTKNKSQKVTLCRRLSSIKRNSSDEKYSNTLSTTKSSIEDIMSQLNNTSLIYAPFSISSIASSPSFYIKDNDCSYLDATRVKNSIIELREEIKKLSILEEKLTLYYEFLLDQQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPL5</accession>
    <name>A0A0N5BPL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPL5"/>
    <dbReference type="STRING" id="174720.A0A0N5BPL5"/>
    <dbReference type="WBParaSite" id="SPAL_0000784000.1">
        <property type="protein sequence ID" value="SPAL_0000784000.1"/>
        <property type="gene ID" value="SPAL_0000784000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000784000.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54444" checksum="914B90097535FE69" modified="2015-12-09" version="1">MNKSQVLHRQYILLYHGYSKVTSNFNSFVLEQSIGSLKKDSFISTTVTLELLDFNIVVRTSYNSEILNLPYSDFCDYAKSSKKPLHFGLIFEEGTSRNKRCYIFSIDANLVNHAFHEKYCSLFNFECSQNFSMYSECDQFPSDVDQIVESTNFFRNILSNDFMDSVNDIEDANDSPIHEEFVGNRQKRKVEDKLLSCHLLAKRPSLGGDTLDKEDTFEYSECYYRTSEKDNNPDTKLLSETSSNALLFYRTLDDETLRKPFMKFLEEQFCQENLIFYIIVNKYRVAKDVSKRIDIGKEIIQNHLEESASDQINIDDKIRKEIFKKSNEGDYGVDLFDAAQFQITEMMKFDLWPRFLKTIKEKQDAFSPLDEQKEYLNKPRLSLHTLKNKLLGRKNKKNNDTINYILNSSSSQKSVERFSIHVDSLGQSFRSTKSSKLDKMFKNYSQHKNSLSRSLSSKEIKTLHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQF1</accession>
    <name>A0A0N5BQF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000811600.1">
        <property type="protein sequence ID" value="SPAL_0000811600.1"/>
        <property type="gene ID" value="SPAL_0000811600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894709" evidence="1">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000811600.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26401" checksum="060243DE976B2E9D" modified="2015-12-09" version="1">MIKIIGIVVIILQLLYNLEGCTFTDYIHIKRFRIRGSVVCMEDGGVPSIYRVQLLIQFSSENEYLLDEVDVNPSDGTFSLFGLCMIPEKFAEEKMRLLLIILEKPYIQDRLDRLEVLSHKEEFNYLIEYSDICYLKGDKQRLFFADDIELISNNGVLHIFNLYISNNAVYDVFGEVRELTGLLIANDGGKSASLFQLKSFLDRYKMITGESQLILGNKKNGFVTYQDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQX0</accession>
    <name>A0A0N5BQX0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQX0"/>
    <dbReference type="STRING" id="174720.A0A0N5BQX0"/>
    <dbReference type="WBParaSite" id="SPAL_0000827900.1">
        <property type="protein sequence ID" value="SPAL_0000827900.1"/>
        <property type="gene ID" value="SPAL_0000827900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000827900.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12276" checksum="FB6276BD126B2DA3" modified="2015-12-09" version="1">MKNTLSHVWRKHGGKYDLYIKADNDTYVIMENLRAFLLNEDLNTHDYHGFRVAASGKVDHHTYNSGGAGYVMRSVKELVEKGFGDSKYCRQADKAFDDLEVRLCLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQZ9</accession>
    <name>A0A0N5BQZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000830525.1">
        <property type="protein sequence ID" value="SPAL_0000830525.1"/>
        <property type="gene ID" value="SPAL_0000830525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000830525.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15421" checksum="B822BFD8ACD758B6" modified="2015-12-09" version="1">LPYYSIYEIGVKGTFKCENQRVGFATVLVSERAVDARIDRPITGTVGKYMKPFYLIGSVKSFSTPVLYATVLHNCLSINPQCTRLLVTKIPQKYIVRTGQRLNLFDLGIVNLGFQASNRTDCSRRRNSTLPLFPVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSS8</accession>
    <name>A0A0N5BSS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plexin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSS8"/>
    <dbReference type="STRING" id="174720.A0A0N5BSS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000892000.1">
        <property type="protein sequence ID" value="SPAL_0000892000.1"/>
        <property type="gene ID" value="SPAL_0000892000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000892000.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55427" checksum="B5E9F1C3A0EE1ED6" modified="2015-12-09" version="1">MYKIKYLNFVFFLIIPLIFLNILLPINANTYSVTGYSSVRTPNNNVAIETLPKSRKRRDIEKGIDDNDNDSGDFDQSSWNIPSDVEVHDDNGTDHLYYEMKIYSNNETIFKKYYIDVEEMLKEPGTEGSIDHPQLVNSYRKAVGIHLNNTYRFYGHTLQQVTIATGGFCYVGDQVHSWLAATQYIAPLMANFGTENTDSSILYADDGKKLVVEWRNVFVRDHVEAGPFIFQMSLYANGDIVFVYDKIPLNPQNITEENHPRKIGISDAYTSEEPFGTILGSPRRSNSTKRVIYEYHKISVPLEQITNKTVVYIMAKPNCIQIENCDECYSSNLQHFECSWCHDETTNTGFCSDQNGLHRRRQDWIQNHCHEKKVDGAEYCRNINSTTTTTVKTTTDHDITKVTTTSESKHSKKEHASIDGTKGGRHFSYLLAIFVLLVIFVACWVAYAYYNPSTPSGQFLIKYRFSQWRIPTSHVRYSASLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT82</accession>
    <name>A0A0N5BT82_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lysozyme</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT82"/>
    <dbReference type="WBParaSite" id="SPAL_0000907000.1">
        <property type="protein sequence ID" value="SPAL_0000907000.1"/>
        <property type="gene ID" value="SPAL_0000907000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894821" evidence="3">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000907000.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27938" checksum="7D581FBE0A7A1A49" modified="2015-12-09" version="1">MLNKVLTVFLLLSTVFVNTNAQYAYATDVMGSFSVSQFSCIKSSGYSAVFTQIYSASNGGLVDTTGCQNVINAYQAGLGTEVYINPAPQSTKQSYTQFDEAYNQLKSANINVRTIWLKVTNPVLWYENPSYNINFIQGMITRARNYGITLGIYTNWYDWYQITASTTTFQQYNLPLWYWDTYGFGPSAEGTADFSDFRSFGSWTSASAKEYALNESCCSAIISKVVYSTSASYLELISNKSLSTPVAGSAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTL7</accession>
    <name>A0A0N5BTL7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aurora kinase</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BTL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000919900.1">
        <property type="protein sequence ID" value="SPAL_0000919900.1"/>
        <property type="gene ID" value="SPAL_0000919900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="115"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000919900.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44980" checksum="B6CC631DC8BA9B5B" modified="2015-12-09" version="1">MDDDYNASTRRFDETIDEENSGDSTNYPPDMTSISNYIDSNISAIEYVDSEDEKRTILIENEYETMETDEEDDEEMDTEVLCQRMDNIHVPRKHLQQKKRETKNEEKKFISLSDFIIGKPMGAGQFGRVYLAKTREEHFICCLKMISIKKLNSHKYHKQLEIEVTLQQRLNHPNILQLYNWFQDKNNVVLILECALHGSMSNDMRNEEKKFYDDKKACKYTVQVADALMYCHSLNIIHRDLKTENILLDHYKNAKLCDFGWSIQTVKNRATFCGTAEYIPPEMLIENEKVSYGKEVDIWALGILIFEMLSGETPFCCTSTKAILARVREGRFHMPCDIDSDAKDLIRRLLKRNPTRRLELRNVLKHPWIMKHYSGNTTIDDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTS2</accession>
    <name>A0A0N5BTS2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTS2"/>
    <dbReference type="WBParaSite" id="SPAL_0000924700.1">
        <property type="protein sequence ID" value="SPAL_0000924700.1"/>
        <property type="gene ID" value="SPAL_0000924700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894844" evidence="1">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000924700.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32899" checksum="09A62ED0DF844D5A" modified="2015-12-09" version="1">MFCFHSIFLLFVFGFNYLVSIDITLQQAQEIVSKVITPLFVGFHYIMDDTSYSTHPSDLEKTGHRLDNLTKIGIVPADFQFKINGGQYGCTKHQVIKLCNLVPIYTYFDHYINNTYIEDQAHLHQRTDDPHRAVSTVAKLIGYFSSKNGSCGAVHSITRIRLSKKTEPILQNRVDVRIYHEPDTKPYRDQKINNPGLYDSIFRPFNFGWKMGNVNTRAGLMRYNELNNNLTIDGKPVDRTYHCAGDSFGVITLEDYKDDMPLVGDELSLLNGQQVAGTTTPKVDEVVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU93</accession>
    <name>A0A0N5BU93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU93"/>
    <dbReference type="STRING" id="174720.A0A0N5BU93"/>
    <dbReference type="WBParaSite" id="SPAL_0000941200.1">
        <property type="protein sequence ID" value="SPAL_0000941200.1"/>
        <property type="gene ID" value="SPAL_0000941200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000941200.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="58796" checksum="5E827D05F7858ACC" modified="2015-12-09" version="1">MDLKSPEGEHIMMLRRLVPTINISQIHDALIAAKFTKVPCRQNLKKVVDYLINQENLNKSNERNDENIEYEDSNLFDFTEIGAIDGKNIIKNISTQRSYNNSVFLKTNIPKNYENKNELFFNIKGYKYTLKNCTVGYKVYICSSCKKIFDGKSKNCTSVNDHNDKNLSKPAFEVSKIVLIEGSERIINEGNHNPECKENFLHLEVVNQIMLNVSKQMKCQVLMPYDGYSLLLDKGQKFANDNNIDVIKFLINFPEFECFSVTLSMRKNRTNTFTTDQLDEILYKTKHNQDFIRKSTEKYILCISDYGLQTLIFSDVWIMDGTFKKKSRNHGQLYCIHAWYKGKYICAGFGLLKNRQKTLYSALFRTLKQEIINYHNKYISYTPQNFFKDKVVVIDREQAVISSLRSTFFCDIVICYFHTIQNLQKRLKALGLQQIYSKKNGRYSLRNENSVENTNLFNCIKHIYTLPLFRVDKAKQFWITIKNDLQKFNSQKVSIKKFNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV91</accession>
    <name>A0A0N5BV91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV91"/>
    <dbReference type="WBParaSite" id="SPAL_0000975600.1">
        <property type="protein sequence ID" value="SPAL_0000975600.1"/>
        <property type="gene ID" value="SPAL_0000975600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000975600.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="23004" checksum="FE02C47DA0B1E22D" modified="2015-12-09" version="1">MKRFMENQFMEHENINEQMDQIFANCIKIWQEETFLFLGNIPRSIQNLYFHAIPEFTNTTSSHLDNLFPNLNVLFLSSIPKTEKECLNNFSSLKIYVSRFIDALELPNNIESCMIYDTPYLLKNDIRMRKYINCTDYYKSSKHFNNEYTLDGQISGTIFFNYFHELYDMQDHFDDICQMHKWYDKYEKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVH2</accession>
    <name>A0A0N5BVH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVH2"/>
    <dbReference type="STRING" id="174720.A0A0N5BVH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000983000.1">
        <property type="protein sequence ID" value="SPAL_0000983000.1"/>
        <property type="gene ID" value="SPAL_0000983000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="505"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000983000.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="66146" checksum="DD334EB7800CDF2C" modified="2015-12-09" version="1">MTDNRLTEIPQIIIEKMKLLETLILAKNVIKTLPTCMKGFNSLNYLDLSSNNLTTIPSAIYSLPLQILLLSNNKLDTVSGDIVQMAPTIQELDFSKNRITSITSNISLLKQLRKLNLRSNRLGALPSEMASLDLYSLDISANRLTHIPVEFCSMQSLIHLSILDNPLLSPPIEIVLKGREHIFKYLQSAISSDVDYRGNYTDWSTNRNSFINATIRRPKNAEKVAAKAKRFAALNSSDSGYTSTGDDQRHSYDMEFSRNSLASIDENHKKETIIINKEYNGCLNNDDEGVDLSHTPKDVRKLNLIEECNDVNNSNNNNNNDINMDSSIYTTLASVTVTDSTYIKPNNIVVKDKEPKNEENPDSVLESTSPTTSESHSPLSESMASLSSPDGENNSTLVIESPNVKDNSNILVPISSNESPPKASNNRTLKPPTKKSPPSKVQSKLSVPSQGKSTLLIKKEPTISKLMKPSITTAIPTPRISKLTPPKKSMSISSSRSTTPSTPISPSNDDDVELMKKLLGSKLLAVTKEDEISKQLSSGVLLCNFVNKLKPRTIPVVMASLSPSQPVPLPKAKKNAENYVNAAKKLGLSEVCFTIFIISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVI7</accession>
    <name>A0A0N5BVI7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4776 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVI7"/>
    <dbReference type="WBParaSite" id="SPAL_0000984400.1">
        <property type="protein sequence ID" value="SPAL_0000984400.1"/>
        <property type="gene ID" value="SPAL_0000984400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895209" evidence="1">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000984400.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41107" checksum="D3D21180E3593D59" modified="2015-12-09" version="1">MGYYYILITIFTNFVFIYGQGTLPAQPDRPDCSATWQTVDLSFVAQLSQCSNYEENRGVPCSPSNPTTCTGRNPFCARMEDKTTYKCCSDTIQDSIEIPFLSPESIKPICPGGAIPFKMPQVMLCSPEIVNFCPTDYTCVEAANGHLLPQDSRSLCCKTSTLYSFAKVFLEMSLSPRLIPYPPINAIDFTTLNVHTSALDHAPEIRTGDHFVLAPYRLQEPAYLKKVTLFHPQTNGSYLHVLMFDPNSQTETLQFYYDRKSVGSKEIDLDTPIADGGFISKRIVNPRNDYSQGNEPPTLNFKQNYRKMWVIMVFKTVEPLTRLYVSVSTDFNTKYRNAHDFLRSSTAQRLGTPVAGTYFFLTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVK9</accession>
    <name>A0A0N5BVK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVK9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVK9"/>
    <dbReference type="WBParaSite" id="SPAL_0000986500.1">
        <property type="protein sequence ID" value="SPAL_0000986500.1"/>
        <property type="gene ID" value="SPAL_0000986500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000986500.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22742" checksum="5FF79AD101CED97F" modified="2015-12-09" version="1">MNSNISTNKVINNVPDYCQVMRIKGSNGEVKELLFPKALDLDRPKRPRTTFSTSQLKTLEIEFEKNPYLVGSDRIFLAKKLNLTETQVKVWFQNRRTKCKRKIIDNGVPRITTSSSLSSNENTSNPSSPNLPQSTINIPSWNSQQIPSSTFNNFNPFLYLPTHVQFPFDQATFFPGSNQINNTFQQSYNPTSNVCQQIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXL2</accession>
    <name>A0A0N5BXL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BXL2"/>
    <dbReference type="WBParaSite" id="SPAL_0001053600.1">
        <property type="protein sequence ID" value="SPAL_0001053600.1"/>
        <property type="gene ID" value="SPAL_0001053600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895135" evidence="2">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001053600.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32326" checksum="C6BD7342FD1CF899" modified="2015-12-09" version="1">MFFLTLLLSLIILFNYNESCLKTREPPKPPPTPIPPAPPRPPLPPPFPIFSTTTTTTTTTTTTTTLACCPPISKTNPPRVKPPLGTIGANLDECSSLRRVSAGNCPRTAQIICSKGIGTITESVLLVFYNGNQIVTSVQGVKSAALTIYCTINGWNLLINGNYQLFSAVSCSQNTLSSGDYADYDGIPEQIIGNSLVSNLLPPAKTSTTTTTTTTTTTTTWCQWPPHCGFPYVKKWHHETPNGYAWAEIEEFPVAPASSGHSHLPPSYPPSPGGSHHPPSKSNNNGGYAWYDSVQYPASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY65</accession>
    <name>A0A0N5BY65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_S9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY65"/>
    <dbReference type="STRING" id="174720.A0A0N5BY65"/>
    <dbReference type="WBParaSite" id="SPAL_0001072600.1">
        <property type="protein sequence ID" value="SPAL_0001072600.1"/>
        <property type="gene ID" value="SPAL_0001072600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="3">
        <location>
            <begin position="326"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001072600.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="59579" checksum="14C889BCFD67A0EF" modified="2015-12-09" version="1">MPTENKSRFQIIENLKKTYSRLSKIRIPTNARLFLNDDKKLCTVEVMYSQRSVEIYAFLRQRRMIFFDSLINNPVTFTSYIGKKDNKTIYNDDNKKKAVFFSEKVNDEERHFIQLIDNLNESVINTFDLSSSKVHGEPILSSEFGTFSLSLDGSKILYAAEKKHKASKYFDSDIDWNDEKKLIESNVGQKFILNESFGEQLNGIFRPVLCLLNVKEGKIEVIDEIIKGENSSPLFSLLTFDSKFIISFVLPQMQLKEGKIFCNNRSGKLVIYNIETKESNVIIENKSIECLINSPCGRFVYFMMREPFGPHDTCLSLIQLNLGTKEIREIIPQKDLENIEDDNVFPGFFMPSYGQRSWSKDGKRLIISTLWKCKEEIVSVNIASKSVKKLTNLPETKGSWSLYDVYEDYIISSVSSPNMAPTMYAGKLNDTTTVEWKCLENLGNKNFAEDEKLIDNDYERLCFDRGNGKYECIFIKPRNVKELNLAVCVHGGPHGKFCKTFFSIFSLYNICKKITIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYP0</accession>
    <name>A0A0N5BYP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYP0"/>
    <dbReference type="WBParaSite" id="SPAL_0001089025.1">
        <property type="protein sequence ID" value="SPAL_0001089025.1"/>
        <property type="gene ID" value="SPAL_0001089025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001089025.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20881" checksum="A6E9FC458B695161" modified="2015-12-09" version="1">MWIKRVYSPICFISLVGLILGHLISVINRYCATYHSITFKTFWTKKLCLRLIFLQYFIPIVIHSYNFFCEPKLVYIPSFDIYVFSFTDKWVSIVNNAILLGTSIISVIVTTILNIAIFCKYNQVISKTSKKEHSKRFLMLSYMAVSTICLVIFATEQLAILYFSSVSRIDGLIFISFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD2</accession>
    <name>A0A0N5BZD2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZD2"/>
    <dbReference type="WBParaSite" id="SPAL_0001112400.1">
        <property type="protein sequence ID" value="SPAL_0001112400.1"/>
        <property type="gene ID" value="SPAL_0001112400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001112400.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34027" checksum="DB6361240C108A1F" modified="2015-12-09" version="1">MYEREIRFAVKKFKDLQLNILVKTFSVKVLVLIGDHVILQDAYKRLKNFKCQGSTPVCRCCTLSPNEYITTFLSEKVEKFLRTDVIHPDLNKGNELYSDYFHDCAEGIFADTIFAVVNLFLLISDESSFEFSRMIRDISKNVCNFSLHHVITNDFFFVSRERKFVYKKNYVSLTGGQQIELVFVIYCFLKSYTERNLSCSPIILCFKYLLQSFVNLHLYMTDITKTTDEIIEKIKGIVDSIQVNIRVCLPEFSSTYISHFLNHYKSMIRALGHPYFLNTMKFEVNFKNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZE6</accession>
    <name>A0A0N5BZE6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZE6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZE6"/>
    <dbReference type="WBParaSite" id="SPAL_0001113700.1">
        <property type="protein sequence ID" value="SPAL_0001113700.1"/>
        <property type="gene ID" value="SPAL_0001113700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="4">
        <location>
            <begin position="287"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001113700.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38888" checksum="93B214FDEFF03513" modified="2015-12-09" version="1">MHFIIGNPKILHNADRNKSFYLTCDASSTGLGAMLSQYDDEGNEVPISFWSYPLSESKRGRAPTFLEMMSISKAVSHYCHVLLGSELIIISNHLPIKGLLKKNDDAKFAELMIPLQEMNYRFEYIKGKDNIIPDDLSSLYQEEILKDSSNLNKLQSDDEEKELISLQKMIFDELRKREKKLEDDKCKMVNCLKVLTGEIEEIDDSSDEEDVEPSSKKQDLNKIGDDIPLLTYHYYKNYILITMEEQLSDSFIKEDFEEKIYDKRKIIELNNQIMIEDLIGIGYVIMVPNSKIEKVLNIAHSLSGHYNAEKIFKWLKDVCFWKNMFMDIQLHVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZM3</accession>
    <name>A0A0N5BZM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BZM3"/>
    <dbReference type="WBParaSite" id="SPAL_0001121400.1">
        <property type="protein sequence ID" value="SPAL_0001121400.1"/>
        <property type="gene ID" value="SPAL_0001121400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001121400.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18935" checksum="9D48E1EB11744BE7" modified="2015-12-09" version="1">MQNCKSYTIINGDYVIFKGEISPLSNFYEKKFTDDDVQESRFFNDANTVYKILRSPKAISVKRLARQIRNYDDQTWINVRDKIMYEGLKLKFRDEELNNYLKKCYLNENKPKYFIENSGHHYWGCNIINVVSPINPRQMNGQNKLGNMLNALAKQMFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZT6</accession>
    <name>A0A0N5BZT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZT6"/>
    <dbReference type="WBParaSite" id="SPAL_0001127600.1">
        <property type="protein sequence ID" value="SPAL_0001127600.1"/>
        <property type="gene ID" value="SPAL_0001127600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="196"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001127600.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35186" checksum="5BBC9ADC4037970A" modified="2015-12-09" version="1">MFYILAESNISTDDILYNMNETYVKDRHICTIENFKLHIGEPGGKFISNPFSFGTTEKSDWYFWLYPNGDSSESKGYLSIVFKSLDYSGSAMKSKFKFSIINNKGEEKYVRESCTLGSYQCVNYWTVPKIVRVDTLLDPSNGLLRNGNLVLLFEIFLIGPNNNITKNHSATQFKLDETLPKLDNYLDQILRRQLSTDCIFVVGKHNFYVHKHKLINRSPVFGAMFKDQLKESKKSVIEIVDFKADVVKEMLDYIYTDEAPNLKEMAVEIFMIAYRYGLNGLKSMAFEHIMNKLKEECLKIFSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZW8</accession>
    <name>A0A0N5BZW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">COPIIcoated_ERV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZW8"/>
    <dbReference type="STRING" id="174720.A0A0N5BZW8"/>
    <dbReference type="WBParaSite" id="SPAL_0001130600.1">
        <property type="protein sequence ID" value="SPAL_0001130600.1"/>
        <property type="gene ID" value="SPAL_0001130600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="232"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001130600.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46900" checksum="D5379630BA23CED2" modified="2015-12-09" version="1">MSLPQNTLRRRRGLLEVIQDLDSFDKVEEKVKEEKNAAKGFASFIVMTLIIILILGHIYDRFYGQKQYLYSMNTADYAESFPKLTVDMQIATPCGNFELDFPQSDAIPKMFDLFGEKNEKGPTLNKDPIRFELSDTENKYWKILQDAHRKKYNKVSKFNELNDIDYVNINLEEQLKEAADIKQEEEKKELSKGHQGNDDNNNNGVFGGKNQIIVFGNGLGVLQIISSNGVNDNSNEGTACRIHGELEIKNMQSETITININGGSNEIESMLAHLQGNVKPGNSSHRIESFYFGDKNFGIVTPLAGVEEISISGKTIYTYNIKVIPTRIYHGSIFSSPSLVYQYAVTSIKSEPPSSEVHSHGGIIIIYELTGTVIEIRESTMTTTQFSLRLCSLIGGIYATVTFLSVYISKLFEVAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0J9</accession>
    <name>A0A0N5C0J9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FRG1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0J9"/>
    <dbReference type="STRING" id="174720.A0A0N5C0J9"/>
    <dbReference type="WBParaSite" id="SPAL_0001152700.1">
        <property type="protein sequence ID" value="SPAL_0001152700.1"/>
        <property type="gene ID" value="SPAL_0001152700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001152700.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30014" checksum="79EAF4905AC8418A" modified="2015-12-09" version="1">MSSSDYANIKKGGFKLKGKISLGITKKKKKVIEKKKEIDHDAESRGGWRRLTLTKDIRGGMDVAFECGDFSKHFLYSQDNGKFKIGPVHEDNSSPDPEEIFTIIKAPDDVAFSIKTGYGRYVGVNANKELVATAEAISERERFEIVSENNKTAIQNVATGGFLTMNRNSDGQVLCSSLVAKEFEMINIRTNSVLDQTVDLTPVEDKLSSGDCETSYVKMYQHSRVDLKNKHICVDVGDRKVIEKAKTEGTLHSTLLDRRMKTKSDRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1T3</accession>
    <name>A0A0N5C1T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1T3"/>
    <dbReference type="STRING" id="174720.A0A0N5C1T3"/>
    <dbReference type="WBParaSite" id="SPAL_0001195300.1">
        <property type="protein sequence ID" value="SPAL_0001195300.1"/>
        <property type="gene ID" value="SPAL_0001195300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001195300.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37765" checksum="8BA884EECFCED1E7" modified="2015-12-09" version="1">MENNHCEKLSKIILQELMQDKSFQMKWLCDSLSRVILLTELKEPDNPVDKKPVEPVVEVIQNDTSTKKELYELLEAINLAIETFLTNSQFVYCHMEYEKNQDAATIYSNKVLLDRLINSDKFNRDRLNHFIRRLRQCVKGFTLRISGSFQVVNCAFYAHSLVELFFNLGTYFEVHREKLGLQNELKRFEIISSEYSELVEKKLSNYLLSYSKSKSKDSLAKENHSITKNPRKNRRSQNFPRSGVLQPQDYNERHNKLKELASDVIKNKNLSESDLNRIKKKWKPLFDSHKIFYSSTVPTTYGTVGLHATNNITKSILNKIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1U6</accession>
    <name>A0A0N5C1U6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1U6"/>
    <dbReference type="STRING" id="174720.A0A0N5C1U6"/>
    <dbReference type="WBParaSite" id="SPAL_0001196600.1">
        <property type="protein sequence ID" value="SPAL_0001196600.1"/>
        <property type="gene ID" value="SPAL_0001196600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001034">
        <property type="entry name" value="Intraflagellar transport 88 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="624"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001196600.1"/>
        </source>
    </evidence>
    <sequence length="834" mass="94584" checksum="4DA687CFDB3A5E26" modified="2015-12-09" version="1">MDGNDDEDDYGGFNDYEHAYDVENMFEDRSFQQALAKSSHGRRPTTAALRQRTGSILPTRMSSNRTESNLQTASRMRSSLMSRGGDISNRPMTAIKAAGYTSMGRKSNFESIQNPFNKESITEETLEDKCKKIEKQVNQLLKESIMAYDSQNFKLSLEKAKEAGRKEREVVKLREQSSSSSSTYNNGSNNDPAVNVDLTFTVLFNLAEQYNANGMLNEALNTYLVIVKNNRVFTNAGKLKINIGNIYFRKKDYVKAIKYYRMGLDEVNNLESTVKIKLLNNIGVSLIKLGKYYDALATFEYAVDEGGDYSTALNLVLTSYCLDDADKMKESFQKLIDIPTMVDDDISKNSESDILAAQIMNNDNLKQWERKRKQVAENTILTAAKIISPAIASTFTEGYAWCVEAIKQSVYAPLATELEMNKAVELLKRGEISAATDAFLVFNTKESKVASSAANNLAMLSLLKGSSADINEAETYADQSLSFDRYNSNAFVSRGNIYFIKNDYTNALQYYREALNVEPSRVQALFNMGLVYQKTNDFQKALECYYKLNHMLANNVQVITQLAGIYEKIENNEQAIELYSQANSLAPTDPEILNKLGRLYDIEGDRSQAFQCFYDSFRLFPSNIKVIEWLGAYYIDAQFAEKAVSYFEKAAVIEPNNIKWQLMMASCERRSGNYQKALNLYKEIHRKFPENVECLKFLVRICTDLGMAEAKIYHEKLEKIEKMKLLREQRENISSQGKRVLSSASSHDSSSTTNKRDGTLRIPSSKSQRESSAKSLLEGEEPYMANTRKLDDLDFRYNDPIGPQASRPKTGHHVHQSMNEMFENDDIDDNLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C242</accession>
    <name>A0A0N5C242_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001205500.1">
        <property type="protein sequence ID" value="SPAL_0001205500.1"/>
        <property type="gene ID" value="SPAL_0001205500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001205500.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="17076" checksum="672B7B8455E59A69" modified="2015-12-09" version="1">XCISIFGVIISKSTTVEDKDNSTEYNAVMTGLPMCPYCKEQESVTVFLYNHYKGEWFNEKCNQPFYIKKYTKIQNKETFNATFHFRCEYEVKVEIKNRWPKSMLEYDGVYYYDFGFIDFRTTEERKKKRKRRNGFRKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2F5</accession>
    <name>A0A0N5C2F5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2F5"/>
    <dbReference type="WBParaSite" id="SPAL_0001216500.1">
        <property type="protein sequence ID" value="SPAL_0001216500.1"/>
        <property type="gene ID" value="SPAL_0001216500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001216500.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49841" checksum="2BB56169AF91FBB6" modified="2015-12-09" version="1">MAIECIICLQSCEASGTRHAPYSTPCGHVMGKECLEQLKMLSKDDHFNCPFCNENIKFNSCRAMYGIDEEDNTEESRNFIKESKENKNILFSKEFRNDINGNIKYFDEHKGYILIAGEGSSRFPGTQFIKLIVTKENKIYDISKSIIKPKCSCLCFNKYNDDVIEFCIGYINGTIKLYRCKFDGNNLKIMDKKSLNNRDFISHLHGRIEINSICFLNNGTVAFSIGKGKLCIWNKSNKWLSKTQIIKEFPYSESDKITNLKSTKYGDCIGIMNNRIYVFQKSGTSYELVSEIGKKIISYSIDEDFNRLLVLYSNEMDKKRKNSTSQSFVFYEIIEIDYTDNFGKKFKKYYAINLIINNSIESKIPKSFIAKLFAAEQSDGTFLYHCILPNMKDIKNCLGITFVDGKEFCIQRNSRNKIAKIFKNKVIVTDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2P4</accession>
    <name>A0A0N5C2P4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C2P4"/>
    <dbReference type="WBParaSite" id="SPAL_0001225400.1">
        <property type="protein sequence ID" value="SPAL_0001225400.1"/>
        <property type="gene ID" value="SPAL_0001225400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="603"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001225400.1"/>
        </source>
    </evidence>
    <sequence length="1529" mass="177433" checksum="D34F359BFF330F64" modified="2015-12-09" version="1">MSVRRTRRNPITVPAGLTESQAYQYIQNMAANGNDQLNLLRNPGENLDGTTLQGNQFEILQSQIRQLIDEKNAHAEQLNQMREMNRSIDQQLVTLTQLIQNLNVQRNTTEENNDDERVPSQFGRSYNVQNSVLRDHNVQNSVQNVAPIIDRHVVEVFSGKNSEIHITKWIKKLELYFKMNNIPEERKASILAYHLSFDALEVIEDYEDDYVMSKTVLIHKFDNDISSVTARQQFYEFRKGPVIRTVGELDKAVIELDKLVNKVFAKEDSSARIQEMHQALLDRLDPRAQAIFKAIPIVYDITNYEQFIQRLKIYLINDIRKPRDKPKVKTCFTPNCKYWWNHKTEECKLKNKSKRIKEVNFVNLYDQINKEQINCDFNDKPEYCIDKYYTNKNTNMYDYENEVNDKHENLIYELVTLNKIDAIAVIDTGSQITAISDEMAEKLHLDLKGIETEEIKLLGKLSTISKIKARITLKYKNKKTTIQNPYIFQKLNVKHDILIGIKHCKRLGLIIDTDNKKVIVKPKTENPVNDKKSQIDELIKELTKKLLDKHSSIFISSDAQLKPTIVAQPQTFSNKSPHEFPIYNMPIHSQKIAQEIANEWLQAGIIRRDIPKNNIIAPTIVVKKKTDGNEESDISNKARLVTDLRKINSIINKIDIISPSIHNLLLTSPRYSFVSKIDLKSAYSQVLLNPANRRDFGLYIANVPYCYNVLPMGGKNSANLFIQAVHQKFEDFIMEGSLLPYHDDFLIRSVIDSDTILDDKTLIKECYKHYDLLDRIFTRMKENNIMASKGKSKLFQEEINFLSYTLSREGWVPAKKSVLRLTKNYPSNKRQLQKFLYGTNYFRISIPNYSQLTSCLYDLLGTLKSDSEKFTFNDEQKQNYEKIIKGLLQPQKCYFGDLSKEYILRTDSSQVGIGGTLSQMFYNPKENKNEELLIGICSIKLPKTLRRRHSTFLELNGIATTLEYFSHILMHCKGIKVITDHRPLIDLQTRTQKPRFVELLSIIHQFPVKSIEYQPGRLNHTPDYLSRLEEEKILKDTDDQQDKGYNDEEYFKALECYIATELQKRKRGRPPKQKNKNENIVQVENNLISNKENMSEEKHDIPDTTSSNLLKSFLDMFILNKDKVRQAQLEDPDCQEAKERGYFMNYAVKYDEKENLIKVKKNFNIDENTIKKESPDESWKTLIPKSIADDVVKMAHLVGHFNYLKTKLTLDSIVVIPQIGTHLKNVIDNCEHCKLRNIGRHKIASNRTISIPDAPYDEISIDLICPKTPDTSGKNYKYILAVIDNCTRFTWLIPTRTKNAPELTHKLIKHVILPGMIPRTVRTDSEGEFFSDHFHSLLTQIGVQEIIKSTPGNSNSNSLVERTIKTANKVISNLMSQNPLLPWKDCLPLVSYAMNNSRTIGREFTATERLYATSPRTILHTTVNEKSYTKFIDRHPEISEMLSRFFIIRRIENDAYEQLRLQDNKKKFEETQGYKAGQTVYYRKNRKHKFDNNYTKATVIADIGPNIVVSKAKKHGKWRKVNKKNVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2V1</accession>
    <name>A0A0N5C2V1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2V1"/>
    <dbReference type="WBParaSite" id="SPAL_0001230800.1">
        <property type="protein sequence ID" value="SPAL_0001230800.1"/>
        <property type="gene ID" value="SPAL_0001230800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001230800.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32766" checksum="BF02ACACE66F4915" modified="2015-12-09" version="1">MVSIASVVDIIQLIYKIPSTLLMILSVFVIIKEIKKKNVHFNKQFYIIIVCKLTNEIIFIITLFIFVKLPKWGFVINFWEKNNWTATTLYVLATQQITFMYLITLFLTINRYIAVKYPLLYKLYFSKPKIVIILLSSILFSTIIGLGTILFNPRYIKSNLYGYLAPSLTSKNEIYYQIFCQVFLSGIIYIATCTFNVMAILTLKKHNMICNKHNRELYYVIYSIFTFITLSIAEAYYICKSITLKYEIKSFDHIIYFLYIVAFDLTSVGDFYFLIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3C5</accession>
    <name>A0A0N5C3C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3C5"/>
    <dbReference type="STRING" id="174720.A0A0N5C3C5"/>
    <dbReference type="WBParaSite" id="SPAL_0001247900.1">
        <property type="protein sequence ID" value="SPAL_0001247900.1"/>
        <property type="gene ID" value="SPAL_0001247900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="781"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="895"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001247900.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="108219" checksum="73E343E5A81D0B7B" modified="2015-12-09" version="1">MSTFSESDSEIEIIVKAPSSKKQNKKQKIFTPVPESNSKIESSSKKQNKRQKKLYTLPESNSEIENFFESSSSKKENKKQKIFNAVPESDSKIESSSVPISSKKHNKRQKKVNTLPESDSEIENFFESSPSEKPIEVITIFDSDNDIENLSIRPPSKKQNKKRKVVTTVPESDNKIEKFFKAPLTKKQKIDKSNSTQFNNEECNFRKIKEEIEEAIITVKDLFDEDKNIDEAIDILESSKENNFGISKSDSKTVSNEFGELLYKALRKLLLDEDKCYVYAYIDSIDELSMDDTIKMVSYIGKGKNFRAGDHIIDAFYFKDNASHCSKDKNPHYRNILRLGEGITIVKFAEAIPETLAYFFESILIRYIGVEKLQNVLNGHQELISEFSSFALNSLGSYLTTLIYEKYNLNEGEQFTLKSFGYKELPDEEFKETTCVVCEEIFTTPQDWMRHLRYGICNGNFSEYSAIEKIDDTKKYVCKCLLSDGKYCNSKFTTVGCLKRHIGYDHDNIFKKIFLTEVHDYKCKHCKYSTKDRNCLKGHVGIHHGDKFYSEYKYRGGHCCEICSIVYLSEKLLKDHYISNHRPEYFNKFGEDIEKFNCEKCCERFSKKENFDCHMSFYHFEEGDDDKHVCPYCYGRYKILKFHVRRQHPEYYEKSIGTFKCHFCPENFTTLPNLNEHKKETHSDKIENKCETCYKTYFNKQSFDAHNVSCEIKCCVKTDCKFVCYTSCQMNVHKTEMHEDYYYIDGNNEYVCNKCHKSYSDIKILNYHILTHKEEYIKAHLTCNTCKKTFSTKYNLAEHMLYTHNKEYKKNNERKCDICQKIICNDKNFNKHMKIHSKRVKSTCEICGFISVSKEGLKEHQKSNRKTSCKKPRCEYIAKNGCDLKKHINEIHKEYRCQEPGCNKEYPNQGGLNRHYKNSHKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3I4</accession>
    <name>A0A0N5C3I4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3I4"/>
    <dbReference type="STRING" id="174720.A0A0N5C3I4"/>
    <dbReference type="WBParaSite" id="SPAL_0001252900.1">
        <property type="protein sequence ID" value="SPAL_0001252900.1"/>
        <property type="gene ID" value="SPAL_0001252900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001252900.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="25087" checksum="C83742DC522DB148" modified="2015-12-09" version="1">MHSRERIEKCEELFLRQEEIYANHYEKKNEEYGPAYDNFVVTSVKKYPKFVNLLMVYLRRCGKHRTTQIDNSFIESLDVSKLPKMMAIIYNEYLLFKKELNKGISNYPPYPSFDRFRETVLKYADEITRMTLSPIIWNLLLKLESKYGSRESLKRIFFRGLESVGWSKEYYMKYLLCESSAFDDVFQLLIEKGFRVRCLKEELPILLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4G3</accession>
    <name>A0A0N5C4G3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-activating enzyme subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4G3"/>
    <dbReference type="STRING" id="174720.A0A0N5C4G3"/>
    <dbReference type="WBParaSite" id="SPAL_0001284500.1">
        <property type="protein sequence ID" value="SPAL_0001284500.1"/>
        <property type="gene ID" value="SPAL_0001284500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="15"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="15">
        <location>
            <begin position="448"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="113"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001284500.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64975" checksum="3E50D530CC80AA88" modified="2015-12-09" version="1">MSWYDEGFINDLSKPVLVVGAGGIGCELLKSLALAGFSNIDVFDLDTIDVSNLNRQFLFRKEHVGKPKADVATKAILRKFPSIKIEYYYDSIMSEKYGFQFFKKYAVIFNALDNFAARNFVNRMCIAGEIPLVDAGTSGYIGSCRPIIPFKTECFECMGQNNGRERTYPGCTIRNTPSEPIHCIVWAKYLFNQLFSEYNEHEDVTPNQKIASNGSENKEEDKVTKDGTNGEPVENLRMFAERISFCPSQIFNKIFYEGPAKLLEHSHLWEKRPAPKPITWESFLDNLKNFQCVGEFDQESVDQHKTLTMEENLIIFADCIKKLRHMALEKEKDDQYLYWDKDEKISMNFVTVCANIRAHVFGISQTKPFEVKSMAGKIITAIASTNAIIAACAMNEGVKILRGLTKDLRISYLVEEPYHKGDLITSCEPFGPSEECRACSEVKRRHYRVNLNLMTVNGLKNEVLIKDMSLTSPSACCNKTGKIIICDEDSIPEEIMRKTLADIGVTSGSFLDIDDFFQQFNLVLCLHHSDELGELEFEDISSSYGEDHMVSSGKRGAADTIDEVAHDAKRLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4S3</accession>
    <name>A0A0N5C4S3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4S3"/>
    <dbReference type="STRING" id="174720.A0A0N5C4S3"/>
    <dbReference type="WBParaSite" id="SPAL_0001295400.1">
        <property type="protein sequence ID" value="SPAL_0001295400.1"/>
        <property type="gene ID" value="SPAL_0001295400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="4">
        <location>
            <begin position="316"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001295400.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="51962" checksum="1CE6A89A25AA81BD" modified="2015-12-09" version="1">MRFLSKVVSNSVTGVKALHTTSAAAISMRSTAGGPPPIERSYPIPGKSPKVVSAAEAVDVIKSGDSVFVHGIACTPTPLLSALCEAAKAKNLKGIKLHHLHLEGPTPWLEADVRDKIRSNSLFTGHNLRKAVNEGWVDFNSTFLHEVPLLFRKGAIKLNVALLQVSAPDEHGYCTLGTSIDTARAAIQHADCIIAMSNKNMPRTFGDGIIHQSHIDYLVEAHDFPVHLRAMPSIGEAEQKIGKIIAEELVDDGATLQMGIGAIPDAALASMKNHKDLGIHTEMFSDGVLDLVESNAITNKYKRTHPGRMTVSFVYGSQKLYKFLHNNPFVHFGDVAVVNDPGVIRTNPKVTAINSCVEIDLTGQIVSDSVGHKFISGFGGQVDFIRAAALSDDGLGRPIIALPSITKKGQSKIVATIQDGSGVVTTRAHAHYIVTEYGVAEIWGKNMRQRAYELIKIAHPSAREGLEKAAFKRFKVMPSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4U7</accession>
    <name>A0A0N5C4U7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4U7"/>
    <dbReference type="STRING" id="174720.A0A0N5C4U7"/>
    <dbReference type="WBParaSite" id="SPAL_0001297600.1">
        <property type="protein sequence ID" value="SPAL_0001297600.1"/>
        <property type="gene ID" value="SPAL_0001297600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001297600.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="49151" checksum="AD00AD8DCDEC7830" modified="2016-05-11" version="2">MYLVFFKNIAYLNIFYDLDVYDKKISKDFDENNYCLFEKFNIWSVIVQSYIKPQTKFKKCEKVRDSKHYKIVDGIITVMNNDMYCFCSCMYSNGSYRLNPTQYIFIGKLFKLDCDIFHLRCYNLSGTIIYDDVYFHINKLNKIPKESTPFLEENFIVPINNKRYDVHIYVIDSLSYYHALRALSKTRKYLKENFNGVEMEYLNAIGDNSRPNAYGFLLNKQNMDVDDIFSYKKTKKNDFGDLDSCGVALDNQTFIQEYYRKMGYVTLSAEDSEFGGPFTYPSCVGFKKEPAHHTLKPFQILSLHTITTKSVKDKLKKECLHHGFHIMNYMSDFLQKYENNLKMTLIWQAMILHDEINLIFAADEIFYNFFKKNEKHYKNSFNILMGDHGYRLNTFSISDIGRYEHKNPYFIITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5G0</accession>
    <name>A0A0N5C5G0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5G0"/>
    <dbReference type="WBParaSite" id="SPAL_0001318800.1">
        <property type="protein sequence ID" value="SPAL_0001318800.1"/>
        <property type="gene ID" value="SPAL_0001318800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001318800.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15536" checksum="372CABABC4E1CA2A" modified="2015-12-09" version="1">MDKIELQDDILCEDSINNPIIIDDSDGKDSEDEILSADNYELPFMKDYDDDSTISESDLCTTAPRCGRLQPHLLSASGLLSTKRNKYQQWHMELCHCSAKELQNCKLQNRSDTTTVPQNNSRYKSHIKPKNMGSSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5K0</accession>
    <name>A0A0N5C5K0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5K0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5K0"/>
    <dbReference type="WBParaSite" id="SPAL_0001322800.1">
        <property type="protein sequence ID" value="SPAL_0001322800.1"/>
        <property type="gene ID" value="SPAL_0001322800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001322800.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67285" checksum="AAE1A9B8BC5F3DB1" modified="2015-12-09" version="1">MPSSLNWCNQNVSELSKDYVAQLEDPVWAQATISDSVYDNPPHFPSNMDKQVRGVAAQLLLYKAGLVVSDLNKVQQITPESIFSDYKYKNVCYTRLPVLVDGRLQFVDNDGYIHEYSVGHPCTQLSPEEVTEFQTTDEKTENQWSWTENFSLLSGLSTYGTSIWICVQNVVLGVLGIVLLILVALLGWKIWKAVQKCRANFRKRRIRQRQRKTILSSLSEVVVLSNLGNTQVSSIGPLQGKQLFVNLYIAQNTSTKIVKCLIDSGACVSFIRKDCLSEFKDIHTFAQPTKIAQDFNNNPILAIGQCKVKFVFNTKKIEIPLLIMEKLHQDVLLGSYALEYLDKANFPVTFKLSSNIIQIGNTRHPLDQISRVSYLSPSELWDTVKTWIWCVRSLDDTLIGPEPEAVVAEELDMPDKLINDLAIWDPLPHTEALIKANLADTQFSEKNQKLLTQILFRCKAAFIHNEEDIGRYSGPIKHEIMLKEKGKLPISGVPRHSPIMQEKAYKLIQGMLKSGIIQHSKSTCTSRYLIVPKPNGSDRFVVDYRQLNTCSYLEVPCIPHIEDLLNKVCQFRYLSVFDVASGFHQIHLDESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6W8</accession>
    <name>A0A0N5C6W8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectopic P granules protein 5 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C6W8"/>
    <dbReference type="WBParaSite" id="SPAL_0001368300.1">
        <property type="protein sequence ID" value="SPAL_0001368300.1"/>
        <property type="gene ID" value="SPAL_0001368300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001368300.1"/>
        </source>
    </evidence>
    <sequence length="2367" mass="277292" checksum="2B3BF6DD8D813D72" modified="2015-12-09" version="1">MEIAPKTKKNKTKTREVVEELGPAPLPPRGIQSYGPKAVPENESKVDDSVKQHEVEHENVTASAPVIDEEEYVTEKSPDKVGDRYKPKYNIGYVDNIATTTQLYPQLQNEVISDKIIGNIGFVIDESGIEKTFPYQPKIHEINLYSERRFECNIVNEINYISTAYKDMEILRNRYKIKGIEGIVHLNQHMNKIMDSDMFPHSIYIEDLLKKFREYSVSKINATVDNQMNVLNLQNSEKDVWTEEIINNDVTGVCGHGSKCSGIITFTNFKFQNESYNKFCNVVNETFNHEFNKLYPLEIGCQSLIIQIEWCLHRVMKSFDEEIKMRRVIEHTINEDSNEMNGSIRKEIRKILACLFSQLRKPIVSKEFSEFIKKWIKMTVAILNKCIHVSDQIAIIIHLLRLPGDLYAGATDLIIPCLTNCTFDQSISYFGLLISTLMKAINNREEFLSEVNTSHSDEDDFLVVNEDSNIENPIKLQPLVVSAIFDRFNINDLIGCHQKSFTTRYGDPSFHLSIFTKFSHLIMILSEGLDNYSGKHVFKDFMIRIAHMQKEIICLLYSLYGATQRQENIEYCNLLKADLSKLMVYFFYKIVNTDCPIIGQVLVGLPLDGMFTVDIYKLNFILTKDTRNLDFNQLFEPSISNLMQERRQKKWDNLFLEMNKEITVHDSCYFNALAEVVSHLDFLDLSFVEQILESFMIDSRKRELFSKTGSEMICSMLMNKPECLKRILDFIGRRHADLNSYALDIFRCSNLSGVIPSISIVNQLGKWLLLFDITHPVARVSISLLKSVNWRNCYKNEEFELYDIVGKLLGQLQQTKCSAINKKIAKGSLNLVKQGEHNVYLEFNNFLWDICLRLPQLHVPFPYNDSDDILNTPISHFLHIMRNCMDTMENFKTYGYFYLEELSKQGCHQAIAVIIGRLLYEFNTQVITNLNNKEFMGIFEAMITSNDSYLAFSMIGLGAKFPTNIVHFFRNIVLLYLHLLMTKNSSKTEIYKYLISVIKLMSLRTQVDYYNTMEFTYIFDCFVRYYITIGLNDFSFDDEFQKEIFNIYLDKASDSKKKIESSMFGFMKTYELPPFYTKTPNCDISEFILLSIYTRCSREWQDLFFEYISKGKSLESAISKVKSRLKVDITLFHLSIIQWLQMAVEKSDENVTYPWILQTLLYQIFEYQKFFIILSKNVFVAQLFRNLTELVLPKIIKNTDDKKLKCQYELYLQSFLEKKFIVRGEYSDLHLVNIWKLNDKSQSIMTNIDLKDYVDETSSMFDYSLKRFELNYQNRQVKGNEPKWLKFKNNWIGLFNQYNNYDASHLVVDFSILQFRTSLPTYTFIGSEKQENYVMANNTMFNSSFNNLKNHVHEYFSNKEKIEELLIKYKTLIPQRMQLTSQSIQGLLYCKKQPFKKCDRPVNVTIVVSTHKDVSNIFSQINQIRSQKTSEINCMKSKLFNDIAMNHAQLNDFVLHIYQTINRFKIFNNSDPLCDNLRYIGQNIFERVMCDTLAEEMLFELFNQFVSDAIKYSAEIICTDDRGKQRFQEQLLFFIFGGSGLLNHVLHKIFQPGMFNNQSITTTYQTICEQLNTFGKAYDARQCLLRFSEILSKESEETLYNLIPVIVKFARKCKNCGEGTEEHSLLILFSDHLAIIVRRTLPGSISAIIKDLVNSSDEIIFPDSLGIALYEKLNIPNVLINRDISTVDTSIINELTTLDILNHIKYTCQKKRLYHKEKFFGILKKNICMISDIIRFLTIIMGHHYIRNPLYISKVGEKMLYLLHETWDFLLFPVDSDNRDILVWEVNEQQFGNFVVDVFEKAISDVTYFSFNIVEVTFPKISKMSHGIQQRHITSVLRLAFRQLRWEQYKPSIENYSIFQNMIYNSDHEISGIIGDISVKINWTYVCDDSNCMVCVFKLFYSLSIYPLSSNDIFSSFIRSMRCLLNLPNWYELTSKQFEDISETIFNNASIERYRNFFDKSDTVLYPELLDILKKISQIEVTNDLEEKSQTEFEERVKKISIYVKIMNKLIFSRKKSEGYIVEKEYITLFDNASSWLRKVYEHNNHSCYYGLVATNLIDLSSVQNEDLLKRVLKSVNDYILNYKEIKTKPILPGFQQILITYHSSISLRYEMTLINELFKREYLQKDIYLFPECDIYFVVDDSILSHILQNFGSYNEYTNIEWILGSILDGLIDRQTSNEKHSEFFMSLENYCLRCLKLNAEITIEFCVIIYYYLQNLTIHLQSVDVKSRRLTHLKSTINLLEQFENKFSSNYIISSFSNMFKKFVSTGAENQFPISTFIKGVILFIKNQKLKNDVRLKTSDKIYKSRYTDFQTLLKSNPITYKNKTLDGNTFKEYFTEEKTLFDAPKFYITYYNKIAEFLPPNFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C902</accession>
    <name>A0A0N5C902_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRICK1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRK1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C902"/>
    <dbReference type="STRING" id="174720.A0A0N5C902"/>
    <dbReference type="WBParaSite" id="SPAL_0001438500.1">
        <property type="protein sequence ID" value="SPAL_0001438500.1"/>
        <property type="gene ID" value="SPAL_0001438500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008064">
        <property type="term" value="P:regulation of actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033378">
        <property type="entry name" value="BRICK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668:SF1">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001438500.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8884" checksum="795853E5B938A698" modified="2015-12-09" version="1">MNPTLQPTSVQKQLKEDWDNRLFIQVVSDNIKNISTFLAKFELSCRSKLADLNDKLSVVEKKVEFLEATVSKRETLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C959</accession>
    <name>A0A0N5C959_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C959"/>
    <dbReference type="WBParaSite" id="SPAL_0001444200.1">
        <property type="protein sequence ID" value="SPAL_0001444200.1"/>
        <property type="gene ID" value="SPAL_0001444200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733483" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="319"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="13">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001444200.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65118" checksum="66A04A9DD2041754" modified="2015-12-09" version="1">MFFILIISILPFYFNCQFPFQDRSPSFFPPGSGRSPPFTSSGPGLGPDRHPQHPRNRDNQDNFQNFIGSFIPSNAREIVTVVSETVLSNVDEVTHSAFQGPSRRWKFPPHMIRRMVRFCRRHPEAQKCHKIPSRIRSKFEKFNSGPNIGGLNFWNRDVFTGLKHYERPKMRRIKLRNFLEGVPSLFHKHVPKTIYGNIGQSNKEQLMKWCQSKSCKEQPEEAINKRASIADGLLAFQYFLTPNQSIEQMDQTIEMNLMRTMQVKEALIKNAGLEGQVEPVNDGTFQHDVLLTEEQSNMMLNQITNGTGTEEEGRKKRSSLFLEGVPTSKWPITEKIKYTFDSTMDENNKVVVRNAIKEIESKTCVRFIYTPTKPSGAHLYYIKYASGTFCGLSYIGRVLPSNPIYLSFSCENSVGIAVHETLHALGLNHEQLRGDRDEYIQINWENINPQQYDFFAIADNKQFTSYGVQYDYGSIMHYDQLIASSNGKPSMTAKINPSVNQRLMGQRRGLSERDVEIIEKMFCMPGCEDRNVYCGHWSLKNLCGTPGTQTQNSWMMQNCQKSCGFCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9G5</accession>
    <name>A0A0N5C9G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9G5"/>
    <dbReference type="WBParaSite" id="SPAL_0001454900.1">
        <property type="protein sequence ID" value="SPAL_0001454900.1"/>
        <property type="gene ID" value="SPAL_0001454900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001454900.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40035" checksum="8C077001930246F3" modified="2015-12-09" version="1">MSIHEHEDDFLLIEDDGEQVQPQGDNEPAVVNPQVPEEDVAFLDVNALEGEVDLDAILGRYSRTLKSMGATVEAVLLLMEMGEEISGVPYHYADSFEDLTNIHDARLAFIRRRAALLAAVGDNPTVRQKDAIDTKAKSCVSKRLDYQVARTTEEIMSMYQSIAKIEATCVRVCINGSGIITFPSTIVPSSLTSLKIKHVSGKLSGRLPDKLGCLWIDGLVIPSPSSPNSLVGFSSLQTLIVSSCDTLKLLLSPLEKNVPLKVIVSLCKPHKCVCEKHIRATSQLDLPFKIVIVPDRRYNGQAITQNATVQKNLFFHRMGTIYYKNSHWIKTFAACEYPEDIAEIQSERKKMRLTAASESIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9L2</accession>
    <name>A0A0N5C9L2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9L2"/>
    <dbReference type="STRING" id="174720.A0A0N5C9L2"/>
    <dbReference type="WBParaSite" id="SPAL_0001459300.1">
        <property type="protein sequence ID" value="SPAL_0001459300.1"/>
        <property type="gene ID" value="SPAL_0001459300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001459300.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31178" checksum="FC16BA53F50426F0" modified="2015-12-09" version="1">MKHKEKRSSPILQPLTSAPLEKGFIDIGYDDHVNSFFIVLKDSYTNYPFASWLPNLKSKSIIKFLMSVQHQVGAFQHLQFDNQSCFTSQDTQTYLKSIGTAYSYSIPYQHESNGGAERLIRSIKSSLGRFFDLNEPKSQALYKTLKRLRQIPYAPRKGRFTKNKSPTPLQLMYNDESREYTHLTPHQILHQITPIFRTGFFKRRPDLNSEWENCVILSRINNRTYFVIDDNNTLHRRTASAVKITEEELDEETTKDLEKNFKVAFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAP1</accession>
    <name>A0A0N5CAP1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium leak channel non-selective protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAP1"/>
    <dbReference type="WBParaSite" id="SPAL_0001496100.1">
        <property type="protein sequence ID" value="SPAL_0001496100.1"/>
        <property type="gene ID" value="SPAL_0001496100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001496100.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25107" checksum="6CAD3A110E6000D5" modified="2015-12-09" version="1">MGYRIILNDDPLDSSFEWAPPIKIVAVVTLITSTLDLLADFLMCAKIAEYMENFQSDVAFRAANGFFLFTGISILVYIFEMTDVCLTLKNEVEDVHMARLAKSMVLALEEVPLPIFLNIMYTHEPRMSLSTTVNIGSWIKLVTLCWGLVKFTKIRFMWCCLPINPKHDTRENIRRCFEFTLYRVVMIIVNFCHFTAILICVLNILDSGKGGKPIYVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB54</accession>
    <name>A0A0N5CB54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB54"/>
    <dbReference type="WBParaSite" id="SPAL_0001511700.1">
        <property type="protein sequence ID" value="SPAL_0001511700.1"/>
        <property type="gene ID" value="SPAL_0001511700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="65"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001511700.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19452" checksum="3122A8DB07A4F2B2" modified="2015-12-09" version="1">MESFFSVKNSIRRSVRNSFKKKISKTESLDSRKTNDLTILEKDIENLHCGKFKAIRKFVIILNLFKSRVPKKTHKVIFKKYDNVFNGKDAVDCLSNHVLPKIDSTGINYIMKAKKLIVYFLKERFLICLSNNFTIHDNSYTFSDDDIYCINENYVVPEIPLNIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB71</accession>
    <name>A0A0N5CB71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB71"/>
    <dbReference type="STRING" id="174720.A0A0N5CB71"/>
    <dbReference type="WBParaSite" id="SPAL_0001513300.1">
        <property type="protein sequence ID" value="SPAL_0001513300.1"/>
        <property type="gene ID" value="SPAL_0001513300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001513300.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37047" checksum="34E27F557455B4B7" modified="2015-12-09" version="1">MTEKFNRLDQEYRRYREATLVTENDFQKSLDDMDKIKKDYETGISCLKQKLTSVLVMDDDKSSSMNEANKLLEDENAVLLNKLDEKEEEITKLKNELNHHRSFKILNDDEYDDDNLLVLDEFKDENSTPENGSKKEETFKSVSSALSKIHLSSLHSPSNSSGFGGSHSHGFISSPLIEKPSNSLTKNSVAGSLSNNMNDISNNDKTATLMTIQPRIQRIIKASNEVGKRLRMISKCFSEISSNIVDGKEPGFHKLASRFNDSSDSDDDINNFENKMSYNSLQFEDVIRKHQEDIQKAEKFLSQVSSNIIHYTTRTPGENNPVCNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBX8</accession>
    <name>A0A0N5CBX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBX8"/>
    <dbReference type="STRING" id="174720.A0A0N5CBX8"/>
    <dbReference type="WBParaSite" id="SPAL_0001538900.1">
        <property type="protein sequence ID" value="SPAL_0001538900.1"/>
        <property type="gene ID" value="SPAL_0001538900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001538900.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14044" checksum="0CBBBFAA93D4E2C0" modified="2015-12-09" version="1">MEPGETINSEFYCQVLEEMYQKLSKKVPALINRKGPILLHDNAKPHVSKKTFQKLSQLGYETLPHPAYSSDLAPTDFHFFKHLDNFLTDKIFGSDEDLKTAFEAFIESRTPDFYARGLKNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBZ4</accession>
    <name>A0A0N5CBZ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYSTM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBZ4"/>
    <dbReference type="WBParaSite" id="SPAL_0001540300.1">
        <property type="protein sequence ID" value="SPAL_0001540300.1"/>
        <property type="gene ID" value="SPAL_0001540300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001540300.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9318" checksum="1809EE54ECD0829B" modified="2015-12-09" version="1">MGHCEEERIIINPGYYPPGVAVPPPAYAPPVAAPVYPPPVYPAYGGYPAYGAYPAYGGYPTVVLEEYGHHHHHHGFFHHHHHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD46</accession>
    <name>A0A0N5CD46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD46"/>
    <dbReference type="STRING" id="174720.A0A0N5CD46"/>
    <dbReference type="WBParaSite" id="SPAL_0001579200.1">
        <property type="protein sequence ID" value="SPAL_0001579200.1"/>
        <property type="gene ID" value="SPAL_0001579200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="12">
        <location>
            <begin position="538"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001579200.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="78541" checksum="3CB978F4F06C9F87" modified="2015-12-09" version="1">MACTGCMQPFTLFRKEHGCSNCAFGFCDKCLNKKIVIEKFSSKPVTVCGPCYEKLSKKESEKNALITISDIDPVRTKSRSEPDKVVNSQKWWGDDALPPPSFRQQYSTPTSFQGKNINKAIEKTSKAEREIREIEERLAKLKNVDVEVIRNPRIMVTNEGFEPDEDDDINVEGILKELDQENITKERKNDESVWRNNSQDINTHSSSSLNKALNKLEDNIKSSVEEVEKIYNMTENELNKYRDDVNNEETKLVSKNDDNQSKNEGSKLFQENPQFDVNAIKTTYIMRSHVDEYIQNMRKRFYKLQSQGNFNDRTFKNEKLSMTSSRCQFKIPLKESEDVRRMYTSTGTKLRIGKILEDLDMFAVYLTYLYADGDIFKDRNLFDQIMTPRVVVTAAIGKLTLNEVLNKNDENLIFDGFVSYVGKSSALNIIRMYQKQGSTFKKLLECKVIMVSKDFNNVNKTLPLPPMKFESDEEKRLFDEGKKYNDEFKKLMNTNVSITAFEGFNICKKSNQSDNLLNRIDEDSLNLKPLRPFETTISKASSCNSFVAYAQSKNYHGTVFGGLLMRKGIELANITVNKFCEDTVYLCCLGNIVFRKAIDIGSVIDLSATISYVDDCYIQVRIFYEVSSIDKAFEKYTSNIMQCTFKYDGSKKLKKLHLNKINDIIIMLDGKFHLEEAKKALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDB8</accession>
    <name>A0A0N5CDB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDB8"/>
    <dbReference type="STRING" id="174720.A0A0N5CDB8"/>
    <dbReference type="WBParaSite" id="SPAL_0001586300.1">
        <property type="protein sequence ID" value="SPAL_0001586300.1"/>
        <property type="gene ID" value="SPAL_0001586300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF259">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="281"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="744"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001586300.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="101196" checksum="D1FA7AF68A0A3C87" modified="2015-12-09" version="1">MIKLINFRMLTTSSPAEKTRDLSSENLGALPVNSFNSFELWNKENELDSSDDSEDDTVSDGYPLNVNPLSDSVSDFTTSDSELYKSSNSVDINWQRIISKKRRTHYFSTPKTKLRKIPSFPSIPHSNNSSSFENYEDDLDDDSFTEYEHGNSKSKRHCKLSVIKELNSPSPFHNSGEINEFNTNFVHPSRLDSKWNPMQTSTKTALNNYDCDTLPKNKPRTKMGTKRIPFGSYNEIHDFTTQCSPIRNVPPLDRCRLIKQQNIFKSEQFGLPTQCARQWGCKGILYLKISLVGDVINFTVNKSIYFANPILDNTSSYVKLELKHRDSTKSSDSYRHSKDVYSHHSNHYYHRKNVSYRTKTVPNTNKPEFNETFSFKITPSNIKKHDRIGISVYSTSPNNELKKGKIGCMTFPIKRLIKKAYQQNDYTFGRSSSGTYIINDGGFFLLGPTHGEKTNFPINKIKLRKFYDDFGTSVDSSSIGTSSIHSRSPLKMTNQNEWRYGQERHQINITNYSQPTNSIINYRTSLDNVGRSTMKNNNLHQEIEDGNKFIHPSNSNSHRQLGNVKSLGLVQTNDLNCDFDNNGYKRHYRFTLPSITATSDSNCDLTQTDDFIDSSPMPPIGLHIFYADSATPNFNYDIRNTIKECDDQKQKPSSSSSSSSSSLNNANAVRRVSSFTFLPNNKKVKRNSADSSSKDVESLTRHDSKRNLNIVSKSINYVKHKMASALSFPILYPSKHEVKQWETSFEALLHHKEGSELFKNFLKEEFSVENLDFWFECEEFKKMKEGKKSYNKALHIYDLYIHEDGSKQVNLDADTRNVTKTLLENGAKSDTFNLAQNKIEQLMAKDSYPRFLRSKRYLDFLQEVEHSEVLHTGGKRNSTGDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDE3</accession>
    <name>A0A0N5CDE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDE3"/>
    <dbReference type="STRING" id="174720.A0A0N5CDE3"/>
    <dbReference type="WBParaSite" id="SPAL_0001588900.1">
        <property type="protein sequence ID" value="SPAL_0001588900.1"/>
        <property type="gene ID" value="SPAL_0001588900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22395">
        <property type="entry name" value="KH-I_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20407">
        <property type="entry name" value="Tudor_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047368">
        <property type="entry name" value="KH-I_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047367">
        <property type="entry name" value="Tudor_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF65">
        <property type="entry name" value="A-KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="357"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001588900.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58153" checksum="2B2250191AA260EE" modified="2015-12-09" version="1">MSNLSDLSSKKLITLMVVSGVSVTALIWLYLRQRKDKPNKELSKKNERRQIDCSEKKEKISLNNSPLVFECPTAPTPDDDKMSKVDVIEEGCAKVDHIQLETKPLQNKSESEENLDKKIKSIGDWASICENKEDKMPEKKIEKCQVTGTGDGETFINAKSPSINSENSDDLGSADSGRASSGETYSARQSYVQVPNFPMYEFEIPHSLVGLIIGIRGQTIKELCERANVKMLIRKHHSLEKQKTHQVCTVEGKREHINKCLRMLRHRFPTTRFPDLNLSPILPAPIPLSPNAPGASPSMLILPFNVSCEAFISSLIDAGHFFLQQPTHPTFTSLPTLDKYMNIIYSQQTGIPELPKPLTSGFLCAAPAHDGWARAITCIVFEEEDEVIVRYVDYGGYARVPRADLKQIRTDFMALPFQSCECYIAHVEPADGTATWSHQANALFTENCLNKIIEVKVVGYNVKDEIPVVEIQYTDSQGHTVLFHELLLRKELAKPSDPSKVRMEPKKNEKSTGVQVLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEP1</accession>
    <name>A0A0N5CEP1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEP1"/>
    <dbReference type="STRING" id="174720.A0A0N5CEP1"/>
    <dbReference type="WBParaSite" id="SPAL_0001632800.1">
        <property type="protein sequence ID" value="SPAL_0001632800.1"/>
        <property type="gene ID" value="SPAL_0001632800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001632800.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38006" checksum="5536B411CB8A9EA9" modified="2015-12-09" version="1">MSTSNNNTQSTQNSNPDVYVGTLTGTVKALSFKQETFTNLNDVNELDPKQDEVVRMALADKDKNDFLFVTRGKKFNYYNFLCNSVSTIFEKKDTLKGDVCGVAVNNNSEILTVTSNGDILLLDNGGENKLSEWNIGPGLQAFTTDHFNDFSIFATGGKENDLKVWDLSTKEKKFEARNVKHDSLNLRVPVNILNICFAGSDDKIVTSTKNHKIRMYDTKAQQRPVIDISWLENPITAMSVGYEKHYVVVGNAIGEMGLFDLRTQRLVHKYKGASGSIRSIVCHPYLPYVVSAGLDRFVRLHDMKKHSLIKRYYGKVRLSNLLLQNNLSFISVKKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEQ2</accession>
    <name>A0A0N5CEQ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5CEQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001633900.1">
        <property type="protein sequence ID" value="SPAL_0001633900.1"/>
        <property type="gene ID" value="SPAL_0001633900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="344"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001633900.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48584" checksum="AD0954DD2DA08513" modified="2015-12-09" version="1">MVHGDQFDKWYDIKTLCYKNGPFVDPQFIAGSENFEMLEQIRLLVVGAGGLGCEILKNLALSGFKNIDIIDMDTIELSNLNRQFLFRDHDIGFYKSDVAAKFIKERFPDCNITSHTCKIQDKDDDFYRKFHLIICGLDSINARRWLNNLLFNLIDFNEDGKPDPSTAMPLIDGGTEGFRGNGRIFTAFDTPCMECLMDLYPPQITYPLCTIAHTPRLPEHCVEYVKLIQWENEKPFDTSIDGDNPDHIMWIYEKALGRAEKFGITGVDIRLTQGVVKRIVPAVASTNAIIAASVCLEALKLTTGIASKINNYIQFEQTEGVSMYSLQLDKKDNCTICSESSKLIRLEKEGTLNDLLDILINHFSLTNPSIQTNTGEYLYIINPLRNNLETMSKNNLKKQLEELNIKSGTSLLIADPSLHRALTFTIQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFE5</accession>
    <name>A0A0N5CFE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFE5"/>
    <dbReference type="STRING" id="174720.A0A0N5CFE5"/>
    <dbReference type="WBParaSite" id="SPAL_0001658100.1">
        <property type="protein sequence ID" value="SPAL_0001658100.1"/>
        <property type="gene ID" value="SPAL_0001658100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895837" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001658100.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15859" checksum="F5F533AEBAF9C5E6" modified="2015-12-09" version="1">MGLFLKAIFVFIFCSILLVYGAPTYDIKEQLAQVREQLNLIESQIKMEPEEENIPLIIPKSIKSGDKVRRQLAWQPMKRSLAWQPMRKRSIFNSDESRDEIINILENRLMEVLSIGERLGVSAGDVIDHLRKSQNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFK6</accession>
    <name>A0A0N5CFK6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFK6"/>
    <dbReference type="WBParaSite" id="SPAL_0001664200.1">
        <property type="protein sequence ID" value="SPAL_0001664200.1"/>
        <property type="gene ID" value="SPAL_0001664200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895901" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001664200.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17450" checksum="68B5DF759BF9887F" modified="2015-12-09" version="1">MSGFYRLLILLFIFIYKTNEVRLPQYEYLTAITGKLTCKYPVGKGAVVTLYTKSVRKSRRKVLSSKYVEYGNAFFISGSIRSFLIPRKGVMITLLTKVGKKQKERPITTKFVEYGYPYFISGAFKSIFKPRDIETASLPGKDTPYVIKQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFL5</accession>
    <name>A0A0N5CFL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFL5"/>
    <dbReference type="WBParaSite" id="SPAL_0001665100.1">
        <property type="protein sequence ID" value="SPAL_0001665100.1"/>
        <property type="gene ID" value="SPAL_0001665100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019429">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sri"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10327">
        <property type="entry name" value="7TM_GPCR_Sri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001665100.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20501" checksum="CB8DF37526A25AA1" modified="2015-12-09" version="1">MLVQLTLVFYLVKNYKRSNNDYIKFLTFTKIAATIVYTYVSIVIEVRSFFPRKVIACYGLIRFVDRYGCRISMAFIIPAILCECLFILYAFNGQFNTLCRKKNFHQNNLVQKLSFALIFSYAAIIFFCFASYFGIGADKLTSDIISNYPDIHFLVYDNYTITGIGNIKGTAFSVCITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFN2</accession>
    <name>A0A0N5CFN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFN2"/>
    <dbReference type="WBParaSite" id="SPAL_0001666700.1">
        <property type="protein sequence ID" value="SPAL_0001666700.1"/>
        <property type="gene ID" value="SPAL_0001666700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001666700.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18313" checksum="0D0EF9A0600791AC" modified="2015-12-09" version="1">MNPTNKYNRSSRFIPPINQTIGLQKFENKLKRVFDKTLKVGNYNNPDINQNNSKIEKPCQNNGYLTLNEMKISRKKEVSEIETYIREEPIPRKVRSKSINHKQIIFNHCNENEMHSKVYPTKQNKQYLNAFAKNQVIEVLESVSIALKNKNSDVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFQ4</accession>
    <name>A0A0N5CFQ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFQ4"/>
    <dbReference type="WBParaSite" id="SPAL_0001668800.1">
        <property type="protein sequence ID" value="SPAL_0001668800.1"/>
        <property type="gene ID" value="SPAL_0001668800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895804" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001668800.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13056" checksum="2EA290369955AE70" modified="2015-12-09" version="1">MKIFTIVFYFAVLLGVTFSIQHMSNIFSESLCSPCKFLFQEVKKVMPTVNTDAEYQFKETVKKACDKNLHTIPLLDKVCTQVLDDLLEEVVKDVEILDEEINAEKICKKIRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH48</accession>
    <name>A0A0N5CH48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH48"/>
    <dbReference type="WBParaSite" id="SPAL_0001717000.1">
        <property type="protein sequence ID" value="SPAL_0001717000.1"/>
        <property type="gene ID" value="SPAL_0001717000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001717000.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17026" checksum="136A3DAB5718763D" modified="2015-12-09" version="1">MYININDPRDPWAWRNKWTGESRYSNDDLWIWVTLCILFVILAIIAISPLLIIKYCRGSCPCDSFFNRFEKFLYTLHNLGNKKKISLRRYNGCGRQSRRIIRSHGNSPRSNNVYYVGRNEPIKPATKHSPSTTGTSIPKINLSTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHE9</accession>
    <name>A0A0N5CHE9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHE9"/>
    <dbReference type="STRING" id="174720.A0A0N5CHE9"/>
    <dbReference type="WBParaSite" id="SPAL_0001726600.1">
        <property type="protein sequence ID" value="SPAL_0001726600.1"/>
        <property type="gene ID" value="SPAL_0001726600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001726600.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49781" checksum="C17E500868442765" modified="2015-12-09" version="1">MREVVSIHIGQAGVQIGNACWELYCLEHGIGPDGLMPTDTTVGVEDNSYNTFFSETQSGKHCPRAIFVDLEPTVVDEVRTGTYKQLFHPEQLITGKEDAANNYARGHYTIGKEIIDVTMDRIRRLCERCQGLQGFLLFHSFGGGTGSGFASLVMERLSVEFGKKAKLEFSIYPAPQISTSMVEPYNSILTTHTTLEHSDCSFMIDNEAIYDIAIKNIGVTSPTYTNLNRLIAQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYSPIISAEKAYHEQLSVSEITAQVFEPGHQMVKCDPRNGKYMACCLLYRGDVVPKDVNSAITAIKTKRSIQFVEWCPTGFKVGINYQPPTVIPGGDMAKLQRAVCMLCNTTAISEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGDFSEAREDLAALEKDYEEVGIDTFDGQEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHM4</accession>
    <name>A0A0N5CHM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHM4"/>
    <dbReference type="STRING" id="174720.A0A0N5CHM4"/>
    <dbReference type="WBParaSite" id="SPAL_0001733800.1">
        <property type="protein sequence ID" value="SPAL_0001733800.1"/>
        <property type="gene ID" value="SPAL_0001733800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001733800.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21571" checksum="BFC1A30AFC35A83A" modified="2015-12-09" version="1">MWKGNRNLNDNKRCTVDLNRNYPFLWRESDGTCQRYPGTYRLSERESMYHAFYMDKFIHLIKGYITLHNYGRFILLPWSHTLKTDAPYYNEMLSLGNKMKEELKSKKNVDYRVGSSSNILYPCHGTSSDYAKSLGVKYVYVVELSPEIETDSIGFIVNEDQLTTIGEEALIIFDVMLRQVYSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI34</accession>
    <name>A0A0N5CI34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI34"/>
    <dbReference type="STRING" id="174720.A0A0N5CI34"/>
    <dbReference type="WBParaSite" id="SPAL_0001749500.1">
        <property type="protein sequence ID" value="SPAL_0001749500.1"/>
        <property type="gene ID" value="SPAL_0001749500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001749500.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40344" checksum="6FB1621A4A85512F" modified="2015-12-09" version="1">MVTLMNYSLLLKKNPKLTLLGPGNVKIPDKEEFNRITESGCIKVMCYTWNIAERSQSSIDAICNSFHSIPSIDRPHIIGISLQELPPSDRTFHLNIVKQLTNLFTNTHYLLSWVRRWSQIQIIIVKNCLKKFTVSFNYKWIPSKIVSKPVRTKGSIATYVKILHLSCVFISCHFSHENKYERNRYSKKMYDLLVKNNDCSKPIDCFFLFGDLNYRLEITWDNELCKKFIHYSLLSTSTKQKFVTKILEEHDELLKEISRNEIFQGFQEPKINFPPSYKYIPLSDKFNMNRTLAYTDRVLYMEKSKNLILPYRYDSLQSCKVSDHKPVYAIFMLNVNNSKILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIK5</accession>
    <name>A0A0N5CIK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIK5"/>
    <dbReference type="WBParaSite" id="SPAL_0001766000.1">
        <property type="protein sequence ID" value="SPAL_0001766000.1"/>
        <property type="gene ID" value="SPAL_0001766000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001766000.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22030" checksum="0D358341E78D7AB0" modified="2015-12-09" version="1">LSSFINRNEISSNQQIDNNEEFKCIKDGESLELALRSTILPDFIQKISKSFLLSDIEKILDSLPVSNNTLPGEPSKTKFGFLLENLKINPAALWKHGPTEEDIIIIVHTNEGDMCLYAGYTCILNTRNLTEIIHLALCFKINTTYPTEPNLEFLLCFFAKKLNSDAVSSTWQSNERRIQMDKFPGASGRQSWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1V3</accession>
    <name>A0A0N5B1V3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 20">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1V3"/>
    <dbReference type="STRING" id="174720.A0A0N5B1V3"/>
    <dbReference type="WBParaSite" id="SPAL_0000005400.1">
        <property type="protein sequence ID" value="SPAL_0000005400.1"/>
        <property type="gene ID" value="SPAL_0000005400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000147">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022568"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000005400.1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120557" checksum="1B5FCDC8D51B9DDB" modified="2015-12-09" version="1">MDKGKGKYGVTVEELRTLMEYRSTEAVEKINTLYGNIHGLCEKLNTDPNNGIEENEVLERERVYGKNEIPPPKAKSFLELVCDALKDATLIILLISAGISLALSFYHPDSGLELDETEAEAGWIEGAAILISVIVVVLVTAVNDYTKEKQFRGLQAKIETEHKFFVIRDGISKEIYINQLVVGDIAQIKYGDLLPADGVLVQSSDLKIDESSLTGESDQIKKSVDHDPMLLSGTHVMEGSGKMIVTAVGCNSQTGIIMSLLGAAKDTKKEETLNIEEKKELLDNFELEGISNKGNGDEIKNKDKKERSVLQAKLTRLAIQIGYCGTFVAIFTVIVLFIRFCIDRYIIAEKEFHINDIQYFISFLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATSICSDKTGTLTTNRMTVVQCYLNEVHHKQIPSYDSLDKFTRDVLVNGISINSAYSTQVIQPKAAGHQREQVGNKTECGLLGFVLDLGQCYQDIRKNNPEDKLFKVYTFNSQRKSMSTVVKIDGGYRVFTKGASEIILKKCNYMLGERGSIVKMTEARVSSIFKNVIEPMASDGLRTIGLAYKDYKEVKNKENEIAFDGDINWDDEDAVIKGLTLVGIVGIQDPVRPEVPDAISKCQRSGITVRMVTGDNIATARAIATQCGILKPGDDFLALEGKEFNKRIRDSNGEVVQAKLDEVWPRLRVLARAQPSDKYVLVNGIINSKLSKHREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFVGACAIEDTPLKAVQMLWVNLIMDTLASLALATEPPTESLLNRKPYGRTSPLISSTMSKNIVGHALYQLVILFTLVFYGDTLFNIKSGRYALLHSPPTQHFTIVFNSFVMMTLFNEINARKIHGERNIFSGIFSNPIYYCIWISTFILQILIVQFGGRWFQTAPLSVDQWLWCLAFGVGTLLWGQVVTSVPTSCLSKRLSIGREDAGEFQRFLPETHRLEDAPEMRNGHILWLRSLNRLQTQIRVVNAFQAGINRHESIYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Z1</accession>
    <name>A0A0N5B1Z1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Z1"/>
    <dbReference type="STRING" id="174720.A0A0N5B1Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0000009300.2">
        <property type="protein sequence ID" value="SPAL_0000009300.2"/>
        <property type="gene ID" value="SPAL_0000009300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893869" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000009300.2"/>
        </source>
    </evidence>
    <sequence length="174" mass="20874" checksum="1C508C08C18FB332" modified="2015-12-09" version="1">MIIKLLYFFAYNVFFFCLPTYGTSNMRIGNEKTYKPDGNVRLQTSIMLMENNWQYFKGSWYKFFDIEMYWDEASEFCKQFDGYLASIDSQRENDFVDKLRKRNDIWIGFTKPRNGYYQWSDKSDVNFVNWGPTQPNEPDVDCTIMAYSKDDTGKWHDYSCNAKLPQYFVCKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2Q6</accession>
    <name>A0A0N5B2Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2Q6"/>
    <dbReference type="STRING" id="174720.A0A0N5B2Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0000036000.1">
        <property type="protein sequence ID" value="SPAL_0000036000.1"/>
        <property type="gene ID" value="SPAL_0000036000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000036000.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11989" checksum="5CB6A6BAD4520B39" modified="2015-12-09" version="1">MYLKKIGIINMERASRKTNKYTTTVKNRSTYKIDFKKAIKFLTFKLVCFSSVTGADKIAIPGDVVDEYMMLFQINGSTSLKMTQMILKIKKSKIFYSICDTFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3B3</accession>
    <name>A0A0N5B3B3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3B3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3B3"/>
    <dbReference type="WBParaSite" id="SPAL_0000056500.1">
        <property type="protein sequence ID" value="SPAL_0000056500.1"/>
        <property type="gene ID" value="SPAL_0000056500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000056500.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43250" checksum="681506E847E33B86" modified="2015-12-09" version="1">MLNCTSLQLFDFNSEISTKIILNLFKFKAHYQPFHKYISVILCLLGIITNNIHIWVLSRKQMRFQSVHIVLIFIASADIGTMLSYLIYIIRFEFFNDEGYEYMWTVFLHFHASISIALHGLSIYLVVFMAFIRCQVMKVKTGQSIWMLPHVALISASIITLTLFILSIPTYLAHEIVERTTSNEGVIKYTINIAKNYQANDCVAFKIYLWVTGILIKAVPCFLLMFFTLGLLKQLRENQKKRNLLFSQNTMVGQNLTEKDGIKEYQQNRKENSRLISRNRGSSKRHNSPDRTNRMLLLMVTIFLITELPQGVFAILNALFTQQFHEFVYSNLADVLDLLSLINCFVAFIVYTTTCSKYRRLLYEVLKPLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3K6</accession>
    <name>A0A0N5B3K6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3K6"/>
    <dbReference type="STRING" id="174720.A0A0N5B3K6"/>
    <dbReference type="WBParaSite" id="SPAL_0000066000.1">
        <property type="protein sequence ID" value="SPAL_0000066000.1"/>
        <property type="gene ID" value="SPAL_0000066000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="29"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000066000.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="71308" checksum="198D0ECC804A84CE" modified="2015-12-09" version="1">MQKLKSLGRRIVKSNDPGKLPSLEEFTPKKIRNFSIVAHVDHGKSTLADRILQLANVVDSNAKIAQVLDKLQVEKERGITVKAQTCSMIYNDYLINLIDTPGHVDFSFEVARSLAACNGIVLLVAANQGVQAQTISNFWLAFERNLPMIPVLNKVDLKTANVKKVQNEMKSLFDMDENEMISISAKSGLNVPKVLDAVIDRFPSPSGDREAPFQGLIFDSWYEQFKGAIPLILVKNGSISKGQKIQSLNNGKSYEVVEVGVMHPDMVPCKKLYAGQVGYIICNMKTVKEASVGETLFDPSSSERIENVEVFKSFKPTVYAGLYPVETSSYETLKLAVERLSLNDPSVVITSDSSPALGLGWKVGFLGILHMEVFGARLDQEYDENVILTAPNVEYRAEIVDNENVRKKRYNGQEVIRILDVSSFPELPDVKRFLEPMANVKILTPNEYMSTVNSICAGGRGSRGDITSIDENRMLINWRMPLAEIVTGFFEKLKYLTSGYASFDYELDGYDETHLTKLGIHINNKEIPEFSMVVPSSMAMDKAKKIVRKLKEEIPRQQYEVNIKATFGNSTKAVCNAVIQPWKKDFSQLLKGNFGGGGMERLNKKLSHQKKGKERMKTLGQIKVPKEAFINVLKNSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B448</accession>
    <name>A0A0N5B448_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zf-primase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B448"/>
    <dbReference type="STRING" id="174720.A0A0N5B448"/>
    <dbReference type="WBParaSite" id="SPAL_0000085000.1">
        <property type="protein sequence ID" value="SPAL_0000085000.1"/>
        <property type="gene ID" value="SPAL_0000085000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="185"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000085000.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56617" checksum="AC4F2626E66DC9FF" modified="2015-12-09" version="1">MDNSEDLQILHENTDNQSADEKEIKDTSSVEVKDKNLSRKRKFKECDEDDKVHVKKKPLKEMNNEGDTNEAFEDLMAEFADDFKDSDIGNTPSILDGKEKKAEANTDGAFEDLMAEFADDLNNDKVDASSSCDNNTGNEIKGKKNSEKLTPKIVEKKSLEEKKKEMVKNMKKIAEPENQSYDSFFDIRIKSPKIDVTLFETVVKDMNKVLVKDIRKTNENCSDNFVTMGVIIEKSECKVSGNGKNYIIWKINGFKHINESSVKVLLFGDCFKSHWKLQEGMSVAIVKPTFSTNDKSKDNITTLMITKDTQVIELGFCIDFGICKSMRTDGKPCSNVVNIKIGNFCAYHLEKHAKDVASRRGTFNSMYSQPNVKMQQKKLLNCHASPVKKIARTFSALPVRKINGALPNKDNIHLLKEQQKQDILMNASKAASCSLNARAILKKQKEREENEIKVDTKKKRNNVEDFISKLRENDKKKEIEAKKNPMIGRAFKGKGEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4A1</accession>
    <name>A0A0N5B4A1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAP-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4A1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4A1"/>
    <dbReference type="WBParaSite" id="SPAL_0000090300.1">
        <property type="protein sequence ID" value="SPAL_0000090300.1"/>
        <property type="gene ID" value="SPAL_0000090300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF12">
        <property type="entry name" value="POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000090300.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31577" checksum="38CAFB30B651ACC6" modified="2015-12-09" version="1">MKLVGQIIRADEKIWNKKKNGMSTLYDAKVPIIKLYFGDGTKIDIQFCNYHTLKNTNLLRYYATSDPRYRKVYIYVKNLLSCLNLLDGEKGLLTSCQISVLVAHFLQKPFKNQKPILPIIPQVCSSFVSPNLSIEEVIENLSKPVDISRIQPLINRKPLASHLAIQFVDYFAEFDFSSYAILMNKADPVEIFPVDLLPKLRLFDLYSNKSISNGDRALEALSVNLKYVRNSIKEGYFIDNFLNSTSFNNLKKIVHMQNKLISFLLYFINRFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Z0</accession>
    <name>A0A0N5B4Z0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Z0"/>
    <dbReference type="WBParaSite" id="SPAL_0000113900.1">
        <property type="protein sequence ID" value="SPAL_0000113900.1"/>
        <property type="gene ID" value="SPAL_0000113900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893731" evidence="2">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000113900.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9771" checksum="94A9C8D0AD121AA5" modified="2015-12-09" version="1">MYSTSFNKVAQVIILLCFISFAVINCETNTQFSNEFKNAPIRARRQLSIGATGQLGDRLHKEKENDLKETVTKHYKDPSDPYGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5B1</accession>
    <name>A0A0N5B5B1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">High molecular weight complex that consist of phb-1 and phb-2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5B1"/>
    <dbReference type="STRING" id="174720.A0A0N5B5B1"/>
    <dbReference type="WBParaSite" id="SPAL_0000125600.1">
        <property type="protein sequence ID" value="SPAL_0000125600.1"/>
        <property type="gene ID" value="SPAL_0000125600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030421">
        <property type="term" value="P:defecation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000125600.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32134" checksum="C8BEA7884C8E6C14" modified="2015-12-09" version="1">MDPKKLMGMTKGAGVAASALAIAGGLGYAALNSIYTVEAGHRAIMFNRIGGIGDDVVKEGLHFRIPWFQYPIIYDIRARPNQVRSPTGSKDLQMVNIGLRVLSRPDPGRLQDVYRMLGQNWEERVLPSICNEVLKSVVAKFNASQLITQRSQVSLLVRKALIDRALEWNIILDDVSITELTFSPQYSAAVEAKQVAAQEAQRATFLVEKAKQLRQEKIVQAEGEAQAAKMLGESMKNDAGFLKLRKIRAAQKIASLMADSNNKVYLPSDGLMLNIADEDYIKSCDVNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5J0</accession>
    <name>A0A0N5B5J0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5J0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5J0"/>
    <dbReference type="WBParaSite" id="SPAL_0000133200.1">
        <property type="protein sequence ID" value="SPAL_0000133200.1"/>
        <property type="gene ID" value="SPAL_0000133200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000133200.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30511" checksum="03C0398BF28FEFD4" modified="2015-12-09" version="1">MMKLDVKNSVNERATADSTISDSQNNEEEILGSEEQVNAEPYTEEHNNNVQISENNVIDILISEEKTAKIDIRDSETLYIYKNTVQAPLPSTTIIAITGSEIAEPTSSRRIYTKIRNDKRMTHDELQNAFRLKMTEKLGREPGLKENILQTQETGDPKPLSCVDFTIVDCNINADDNLKCVHCDNLMNTKTFINHFFEKHQSEIEVPKCYLCLLELIINARLSEKFGHDFQITLPDEEHFYCGKYGTKHSKEKALEKGIVAKLKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B640</accession>
    <name>A0A0N5B640_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallothionein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B640"/>
    <dbReference type="STRING" id="174720.A0A0N5B640"/>
    <dbReference type="WBParaSite" id="SPAL_0000153000.1">
        <property type="protein sequence ID" value="SPAL_0000153000.1"/>
        <property type="gene ID" value="SPAL_0000153000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001396">
        <property type="entry name" value="Metalthion_4_echinoidea"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00873">
        <property type="entry name" value="MTECHINOIDEA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000153000.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9534" checksum="D869B56E6B48577E" modified="2015-12-09" version="1">MIYTLSNKVISFKRHQSSCRFFFSYFKPPHLIMDCCKKGESCSSGKGSDACKAKCGNDCKCPNCKCGASCKCGDNCKCGSDCKCEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6J5</accession>
    <name>A0A0N5B6J5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0160 protein MYG1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6J5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6J5"/>
    <dbReference type="WBParaSite" id="SPAL_0000168300.1">
        <property type="protein sequence ID" value="SPAL_0000168300.1"/>
        <property type="gene ID" value="SPAL_0000168300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000168300.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39432" checksum="77A62D2591CBD727" modified="2015-12-09" version="1">MSTATIGTHNGKFHTDEAFACFLLKCLPEYKDAKIIRTRDQGLLDTCTIVVDVGGVFDHEKKRYDHHQKSFNETMASLNILPDFNTKLSSAGLIYAFYGKRAIASILSIDENHKHIPLLYNKMYEHFVEAVDGVDNGISQCNCKKEDKNYCKAESLDGRVSSLMPYWNDPDQDTDPRFYKAIQLTGESFTDKLNYYYKAWLPAREIVEKAVEDRCDFHESGKIIFLPNGGLPWKSHLMEIESEQELSEDEILFAIFEDSQGNGYRVSTVPLHDDKGFEFRLGLHEEWRGVRDDELAKISGIPTAYFVHMSGFIGGARTLEDAKEMALKSMEHAGCIISRSKRVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6T9</accession>
    <name>A0A0N5B6T9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6T9"/>
    <dbReference type="STRING" id="174720.A0A0N5B6T9"/>
    <dbReference type="WBParaSite" id="SPAL_0000177500.1">
        <property type="protein sequence ID" value="SPAL_0000177500.1"/>
        <property type="gene ID" value="SPAL_0000177500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000062">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="109"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000177500.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51560" checksum="5D92C7F1C4873A6B" modified="2015-12-09" version="1">MTLLNFKVTTITNSLCQLNVAFFPYDIQTCTLLFGSWAHSNDSIKYSLYSKNLSLIDFYDNQEWELDKVNSQISADGFLYDYLDPPLFWDMVIIDLVVSRQSFYYVFNLVIPSTIITFVAVIGFHTPSTSGRVRDAKFRLGIMTLMSMSVILLAIVEDMPKFSMSSTRKGRGSFSGIPLIGLYYFILLAIIGLSTVTTSMFVFLERDVRRKHVIPWYLNWLSFDIPARNQMNHNVVYNEINGSISKPPKDSYYTNAEGTALITSSSESNLSVGRNNRMKDCALSMVQLVSNKNDNPYQDTSTTYYNDNAIANSTTTDTTKDVNGRFNIQKGKMIINPMNNVPNFQVDLFQQNLSNILSSMLSILSTISGTCINVRKEMSNMIPQDDYNGKWQVVIRRLELISLMFYITLLFSTMFLFFYHDWYCAVGHNPCGQQNLKCPWMHVNPNDPSCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7R6</accession>
    <name>A0A0N5B7R6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7R6"/>
    <dbReference type="STRING" id="174720.A0A0N5B7R6"/>
    <dbReference type="WBParaSite" id="SPAL_0000209000.1">
        <property type="protein sequence ID" value="SPAL_0000209000.1"/>
        <property type="gene ID" value="SPAL_0000209000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893918" evidence="1">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209000.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="15701" checksum="5105F991F5B39D58" modified="2015-12-09" version="1">MNKIFIFSSIILVIGVLYTSVNCQGFNAGFGGGVDPRFASPGMGGANFNGGFRGQGPMGGRGQGSFGGNGFSDRRGPGGFNGNNGNLISVVEAMQALVEIMETLVDVEASMEEEDQWEDVETSEVVEVSMEDLEVLMVDSVVVAHLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7U5</accession>
    <name>A0A0N5B7U5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7U5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7U5"/>
    <dbReference type="WBParaSite" id="SPAL_0000212000.1">
        <property type="protein sequence ID" value="SPAL_0000212000.1"/>
        <property type="gene ID" value="SPAL_0000212000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000212000.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42566" checksum="0775D6058C7A28DB" modified="2015-12-09" version="1">MTIQYAHDVRDASIWSNIKILLKWKGSVWKDIYKEFIIWAFLFVIIKLLVTFAFNEEQKFTFDKISYAMMKYESFIPLTFMLGFYVTQVFMRWVLIIDNLAFIDSFSIYCTQYISGMDIRSRFIRRSILRFMATSQILVYRDISPKVRKRFPEFASIKNEGYLTDYEHETLVNNARNTLAPWWIPVSWSMKLIIDASKEGRLDNNHFGVQDCLTKIMAFKGSLQQLLVFDWFPIPLAYTQIVSIAVRSYFFFCIVSRQKGMSNEYYDKKNKSLDIYVPVFTVLQFIFYMGWLKLAEKLVNPFGNDDDDLDVDFVLNRNLNAGLGIVDKDLEYKPQIVPDIFYMKLYPQLSDISPLNKYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAP7</accession>
    <name>A0A0N5BAP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000311400.1">
        <property type="protein sequence ID" value="SPAL_0000311400.1"/>
        <property type="gene ID" value="SPAL_0000311400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311400.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9462" checksum="49300016AE9C8A7F" modified="2015-12-09" version="1">MDKKVLKVKSGEDRENCPVAFEDDFYVGHSKLDTQHSGPYEIQRIKGANVWIKPMSGGAVIKTHRKFLKKMLIDEWSPEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB53</accession>
    <name>A0A0N5BB53_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BB53"/>
    <dbReference type="WBParaSite" id="SPAL_0000326300.1">
        <property type="protein sequence ID" value="SPAL_0000326300.1"/>
        <property type="gene ID" value="SPAL_0000326300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000326300.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28987" checksum="83CDA592B066EEAC" modified="2015-12-09" version="1">XIFFVSINQTKFLDTTSTIVSSTNPCIEGYPEKICDGQIILAVDASNNLNTTSFNDEIDVIRNNIAYGWEDFEKIALAWYNDKTLKLPFTLIDSRKLFNIILSVINQDSGLSLTNLLSNLNSLKLPLSNTLSTFIFISSTTNDDIDNSVEYAKSLKNKGTLNFIVLGDINQSMYLEEKLNPSNIFYYDFSMGNVTNLVKFFNDSMVCEVKCITSTISQSTISTTTNYESTTTFKHDTSTDIHSIFNFINNIFYINTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBE5</accession>
    <name>A0A0N5BBE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CNDH2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000335300.1">
        <property type="protein sequence ID" value="SPAL_0000335300.1"/>
        <property type="gene ID" value="SPAL_0000335300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000335300.1"/>
        </source>
    </evidence>
    <sequence length="977" mass="113336" checksum="021E4E570B2E76AA" modified="2015-12-09" version="1">MDMEVDGEDFHWRKRFEKCIANPDSRGEISELVLDLEKLALDMAKKKITMDPHLFIEWVINLGLRTSNLEQAIRLLMSGMKMNYLAVERLDVDVNEFREFVCYDQKKKSSEENEEDVRAAKQRKKERELERKKIKWTAKMDELKEQFEYEKDECSRQDDFNVPKQILRALSDGNTDPFNEVFNLHQLVIDEKLHKIKEVTTTVKITKRKQKKLEKVKIPKVYFDDPFFQEATSNYEEGNVCGLISLNCRRDIRGRVMKINGKCNFDLKQHELGQPSWFIRDFHKVVNECLKEEPTKELYRVHSCFPEPPYNFDEPSGFIYENYKPFVPEIPKDSARRIYSDCMYINGLSKEDALKIYGIEEDFLEELNKLTKGEGDFKEIMEKLKKVIPKKSLRELVWSDEEFDITKKENLDKVYNPYYGYETINMEFLPDLTRFDEMKGGKFRKMTDESGEIKFFFGREFIPEEPHQVKNIRRSSHLLDSAKSLDMSQQINELSMANDVLNESGASDTNLNNSFDDLEFNPDRTSRMSFIDNSLLEEERPRKTDVMNFSQLPRGVDQSFWKYKNPDTKKTPRVKSSLSNKGTPKSKKRSSSTRLSQITPKSSRILRSHSKKLGETPLPQIKEEFCGDVFDGGIDDEVCSEPERVPTSDVEEESSHNDSYLSAVDEQGDTNTEDDEDQPSDNEGSNRDFATPSMEVDDDTPVATDDENTLIEESDDEIFICNEELLNGSSNNKGISSATPKPSHELFKNGMNLLHNNSSDCLGPFGQIYDEEELRPIHVKDNIPKGYDKVVTDENAHSFGYMAMKYSDNAGKIKSTTNVTYINAPLIKCAIFDVLSNSQLDDDNCESFNYIMNRAKTGDYKDIDREKLREQFGKCLEFKDALEKLRLSFTSTMKTRVKHPLPDEIIINGHHTLRSLYYCVCQIIPQSKDSQLHYLTFINLLLHMNNRYQMTFIDPSTNMEPDGEAPITCYIKKHSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBI9</accession>
    <name>A0A0N5BBI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBI9"/>
    <dbReference type="STRING" id="174720.A0A0N5BBI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000339700.1">
        <property type="protein sequence ID" value="SPAL_0000339700.1"/>
        <property type="gene ID" value="SPAL_0000339700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000339700.1"/>
        </source>
    </evidence>
    <sequence length="721" mass="85229" checksum="C7A36F802B8F4445" modified="2015-12-09" version="1">MNNYFKIAGTIFQILIKRTFSSYSTMSYCIECRTFIPQDLYCDHLLRESRISGKNKITCCYDQKAKCYMKEYSISYWRKHCEGHIALSSEVSPPSTFNIMDMEIDEQVVFDEEYINYAENEVKIDYVKYIFADFSAKIFSKVKSHEIVDLVVSELQNLITKIEPFQYDLKTFKEKLESTISTRKKREASIPFKVKCFKNAIYFVEPLDIFKYFWSRDNFTKHITTKGSEEDCIVNEFDYERGKLMVEQIKKDYQNDCLFFATYIDECNVYGRTKLYTIAFKILLLDNLISSREIAFFIVGYCNSNTDYSIVKEFLEEKTDIIEKQKFLHIGDNLELAKYWNSSGNFGSFGAESCRFCLTKNMNLELVVKESTINRENRVIRTDDYFLDSCHDFYLGSNLYFIHMWTLWLKNTDFSLESFNRVLSILPYGEFEKITPFTSFESVTITSAVSKSVIIFFPFIMKFLTLEYQYQVDDFDDYLYLYRKICKIERIINSQKLYQKDLDNLSTIVEEYLTKLKFLRQRTGAVTGRQLYIKPKEHNLIHMVNSIKKNSNLYRHSSIRYESLHKNGKRSIINSNNKKNASFTAASKNLFLLYSNAFSFDNDNFTTDESLFKILTFKKPNVTRIRRNLENNNDVPLLFKIIEKDGVNVKGEVYKFVCQMGVLDAFVLDNEYTYNVDEILIYDCFSIVLDSSYVLTILRNVNHGKEDEENKKRLKKIYKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCI1</accession>
    <name>A0A0N5BCI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000372750.1">
        <property type="protein sequence ID" value="SPAL_0000372750.1"/>
        <property type="gene ID" value="SPAL_0000372750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="32"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000372750.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26658" checksum="B91C53219B06ED04" modified="2015-12-09" version="1">MNISKEWNDILGNYGYHLQHLQLFTSPVAISISVFAFSLFYKRNVYHDNFRIVIQALTISLLSNNMMIFSHSYTSFKDDSFNFDLIDDIEKMKPLKGNLHICDKYSPIPLPLMFINVSMLFVLIIERNVAIYTFGKYEKLQFGNTIYYFCIPLWLFSLLLIVYDFFAIVGIDGNFLFKFCHSVFVQKFYWKFSLPYVAALPPLVLITFIFIKNYKVSNCIKNIINVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCV3</accession>
    <name>A0A0N5BCV3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCV3"/>
    <dbReference type="WBParaSite" id="SPAL_0000384800.1">
        <property type="protein sequence ID" value="SPAL_0000384800.1"/>
        <property type="gene ID" value="SPAL_0000384800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="76"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000384800.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47702" checksum="2AD26F1DEA0E603C" modified="2015-12-09" version="1">MNGELIENTTDGNDEKNGTTNDINKKLKLFQGDMVLNPNQAEDLLDKVVEKVESTGIQISEIIGERRRRKKRKMDANMKLTWKFPILYFVEREVNGSLIDIALKLMELETCIRFQRVYNIVSLEAGLRFFAGDGCYSSVGRRFTYSFQDVSIGEGCDTIGTVQHETMHALGSYHEQSRSDRDNYLKVFLENVEKENEYNFLKVQLSSALTYDTKYDYGSDMQYSTTAFSRNEKPTMLPVEPLYAKTLGVNSGLSFVDAKLLNSYYCMEKCRRPISCANGYQNPNDCERCKCVDGYVGNRCDKLPPNTKECGVSNLLVLNEKKLLFVVGKKDCIYHIRTRPGKKLKMTVRILIYFPGYKTHCKLENSLEIKYLIDKTVTGALLCLFDNSTTIISKGEHVIVHHRSTKVNNGVKLEIESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDE7</accession>
    <name>A0A0N5BDE7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">protein adenylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.108</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55932"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fic family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.108" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDE7"/>
    <dbReference type="STRING" id="174720.A0A0N5BDE7"/>
    <dbReference type="WBParaSite" id="SPAL_0000403300.1">
        <property type="protein sequence ID" value="SPAL_0000403300.1"/>
        <property type="gene ID" value="SPAL_0000403300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Fido" evidence="21">
        <location>
            <begin position="299"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="413"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="18">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000403300.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="53385" checksum="35287532793687B5" modified="2015-12-09" version="1">MAVIESTINLSTKKFIFICILTTIIANTSWNIIINTIRHTDFCNFKWINENIKNNYLKCNIQKGILPKNGGLDIKKVNDDFPFMDTQVLDISQYSGNRDDVIYQPLIKTTNDFAFSENEAKAVLIASKNSRERGNFKKAQAIIENALLKSPLHTDILMEYGIILEKEETGIILADTIYTKVLNYNPYHSEALIRRQRTLPIVQKYDNKLLKALYYKRDEFYKIRKNIGAFRRALKECYFQHVYHTVALEGNTMSYLQTRMFLETGRAIGGKSIFEHNEILGLDAALRFLNQSKISLGGIGLPEILQIHHKVMAYVDPENAGKIRKVQVYVGGFTPPAPQYIDSEMKNFIEWLNDYDTLQMDPVELAAIAHYKLVFIHPFVDGNGRTARLLMNLILSRSGFPPIIIPLEERLNYYKTLKEANDGDLRPFIRFIIQQTDKTLQYFIDTTATNLEKDELKESQLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF1</accession>
    <name>A0A0N5BDF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF1"/>
    <dbReference type="STRING" id="174720.A0A0N5BDF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000403700.1">
        <property type="protein sequence ID" value="SPAL_0000403700.1"/>
        <property type="gene ID" value="SPAL_0000403700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000403700.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61079" checksum="DE0832130C0FC516" modified="2015-12-09" version="1">MSDTSSETKSIDIDDRLEENTTYDKLSWSRTLFLIVVSIILTTLTNLPSGSSHTTINTGATLIDEYMNDSYTSRGNELSHGQISLLRSGLSSSWYVGQIIGTVIAPVIMNRLGRKPAYLISIFCMTAACTLQWLSTHMPYPEIFFAGRIIGAVFSPLADAALIIYTREIAPPSLAGALGSMMNPGFSACALIGALLSTKHILGDSLKKMLFVPVMPGVIGILFLLWIPETPKFLYLSQNNEKKARKALKFYMGNETNVDGIIERYEVEKLQEMNKESGKFTDIFFISHVRKATLLCLVVFMLTLPFYPFLSYSTHFLDKLNFDHAISQYISTVVMVLLTVTAIVSPIAINKFSRRGMTLGVGIFGYICITLFSVCGYFNYISEQMKYFSVVFMIGYMVSHGLAIGSIAWFIGTELVSHEYSSIVLCFCIGIQSFMIAGTNFATMPLYDTFGPLSLIPLFVIPSILFFVIVYYHLPETKDAVIADVILQLKNGIRGKTNIFPLTVPLILGENLVKKAEAAGGELRPMSPMEIESAATSTVTSTTSSILPIGCDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDY1</accession>
    <name>A0A0N5BDY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integumentary mucin C.1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDY1"/>
    <dbReference type="STRING" id="174720.A0A0N5BDY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000420900.1">
        <property type="protein sequence ID" value="SPAL_0000420900.1"/>
        <property type="gene ID" value="SPAL_0000420900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894224" evidence="2">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000420900.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="18536" checksum="52F6BDAC60069B90" modified="2015-12-09" version="1">MKFSVVLVFLVSLLALVSCKSVRSVGSEKQLEPKDESLPSLRADTDNNNATSNDATTVDATTVTSTEATTTTTKAAEETTTTTTEAPTTTTTTEATTTAGSSTTAAAVTTATGETTAAESSTATTVAPIETTTTPQKRSTSPGGTEPTPSPTPEPSAGSVNNLQLKALLISIFSYSLIFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE03</accession>
    <name>A0A0N5BE03_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BE03"/>
    <dbReference type="WBParaSite" id="SPAL_0000423000.1">
        <property type="protein sequence ID" value="SPAL_0000423000.1"/>
        <property type="gene ID" value="SPAL_0000423000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056872">
        <property type="entry name" value="TTC3/DZIP3-like_helical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24525">
        <property type="entry name" value="TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="706"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000423000.1"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154356" checksum="5B2A933BFEC8A58D" modified="2015-12-09" version="1">MVNSTPSRSVSNVSQNDTPETSTGSSYDDAYKFVINFRISNFTSLDDTVKSVPYYVDHTYWRVMAMRRHSDGKNKDSKKENLRPSDFTLGIFVHCTTDSYSDEWSVEAQACLRILNLANTGNPITRELMGHQYNVTETDWGYSAFAKWVEIVDENNGYLVDGAIQIQVEITAKKALNLMDYQTFWRKGTDLLKIAELQLERGNVDKAIEANGRSSALCGNRCRKLKAKIEEQKSRLSQVAISENIKRIESMSNSGCHELKNASTSALKQAISTSSIKKVVNKAKHFGIQMPGVRNGDVRNSRRSSLQTKSNNSKDNDEEDTACTSPSCLCSLSPQSNNSSNFVNESCGYNDNLEDNTVRSAQEPLNPESSSGPHSRKSSLSVYGYPNNEYCKGDTNVSSYNSQRLEVIKQTARIEYEVYQDFTTKTILRNNINEYNGESQNNPSWMNINSLPPFTWENKGFDNQTLLSFRTNKLDKPHPMNFLTPVNFQMNNCSRIQIEEKDMAPTTSRYMENVIYNNDHNYEWWPEVPEGQTFEAYHKIPRSLCIDERVKEQEDMAKLSEFLKKNMIGMWKSRHPDLNQKGKNFFKLLADLDTKMSKFRCDPSEEDIKSMVENKQSFEETINHAFIEACHLLNANTNDTVKRNMFGKEKDNYVDEDCFDDKYLNSESSFMLVPARICDILAHLYSRWKWIEVVYIKKCSLANDVNEELHKDLRDTVIEKKKLSEEIAALSSENASVKEMIKSLKTECKILTEKCKVNETAIESNRTTNALYKNVLKEYNGYKKTSEEEVAKLKREIQSINDLKKKFQTDYNSLQESYKNLQKLAEERNNLVKKLEKQLNDQKKANEKEVNTLMERCKRVEISLVEKIADNGIIFYDRAKEQAEIELNSWKEKQKEFTNEEIVKNNIKLFEEYIANIEKQITTIKNDFENRSAQISSGKNISQIGKLKISKPPLLPKAEPLPLPKKKATPPKVVPATMINRQPNNPMPNYGTPTRGLSSTNPTFTNNISEKSAFRPPASTYSKDVPSSSNNLIYSFSPINNSSYESKPSRSENSSITPIGVKPNNFKNVSDNSGSTSRNSSQVIKDDSSINEYNNNDKPDNIWGVWNPLSSTHEITSIFHETPKKSKDNMTYDFPKDPFDFGISREPLSNIWTTEEDIEVSDLLKINTNYGTPSKDLVKGSQNMSYNSMYDGVRGETGMANNFSPYSNASSTNNYRRLPYGGPSNQSDSINTQDWYNNTMSWNTTTNRNIPSFQSKSATPQQGTATNHRYLPKSDSVSKVQQGQSSSQQPQSSQQPTQYSSYNSQPDSGGSVINHTGIGKNSYNQGSQSTSNIWDWQTTNYTNTSNGSYQNSRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE34</accession>
    <name>A0A0N5BE34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE34"/>
    <dbReference type="WBParaSite" id="SPAL_0000426100.1">
        <property type="protein sequence ID" value="SPAL_0000426100.1"/>
        <property type="gene ID" value="SPAL_0000426100"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001299700.1">
        <property type="protein sequence ID" value="SPAL_0001299700.1"/>
        <property type="gene ID" value="SPAL_0001299700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000426100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001299700.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12760" checksum="DF358D36AD9248C4" modified="2015-12-09" version="1">MSSQYHRDKEYLFEIQLKLTDVIAKAGKAGNPIEKEILSHQALVGEMKDTIQLGFERKVAEYIYNLHHKLGYDKSHEIFNVKSYFLHHHRIDEEQFREIVGRSSCIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEC6</accession>
    <name>A0A0N5BEC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEC6"/>
    <dbReference type="WBParaSite" id="SPAL_0000434900.1">
        <property type="protein sequence ID" value="SPAL_0000434900.1"/>
        <property type="gene ID" value="SPAL_0000434900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894151" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000434900.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28755" checksum="9F7B23E389266042" modified="2015-12-09" version="1">MTLFLELFVLLVSTGYFSLAKEVSDYNYRYLYSGLGKENGKSGSFHISMASDGKKNEWKTVINDDGNIDILEKVPVLKNIVNSHKSDGKVNIIHGRNIRRKEMTNYRRAPIIYEWTSPSDSKETFFNTLPSPALNNVNNMVSKPFKRLESNEILTSPENTFTAQPLNQKHMKFLHPREFFNSNFNQKMDFSIPWFGARFFEKHQPIPESTSPQDFVRQHTINSYGNGRLLFNEMQEKLNTLFKDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BED4</accession>
    <name>A0A0N5BED4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BED4"/>
    <dbReference type="WBParaSite" id="SPAL_0000435700.1">
        <property type="protein sequence ID" value="SPAL_0000435700.1"/>
        <property type="gene ID" value="SPAL_0000435700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000435700.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42621" checksum="A4CEA7D587F8CA13" modified="2015-12-09" version="1">MEEQLFPISIELISNEDWKSWEDSLNKKMNNELKILSEDFNYKINEISKTVGKIKENKMEIEAKCKETNTDLGASLITSEYAYNKAYVLHSWHYIEYERKKNNIIILYQQLKEDFLKLKNQNNNLNSGNEKEKINVDNLEQELICKRKRRLGTGTEIKQKEIDSFLLSKCNLLIKSFESFDCFIQINFYKVAFAKTIKEMVINAYREKMIVNVRDQSEKERKFMLDLNSNNLEHDFNGDDGLTKYYLKLLIKGLDDGLDKKTTNKKIKVIVAGLRLTEIELLSDIENGKDSKIVLDNDQISLLYNYMRHINANYHVTFLKKSKSRFLDKLSAYISYNQNSFKGNYCTEVISYEGCECESDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEP8</accession>
    <name>A0A0N5BEP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEP8"/>
    <dbReference type="STRING" id="174720.A0A0N5BEP8"/>
    <dbReference type="WBParaSite" id="SPAL_0000447200.1">
        <property type="protein sequence ID" value="SPAL_0000447200.1"/>
        <property type="gene ID" value="SPAL_0000447200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000447200.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35070" checksum="CF23D23E2EC1DB15" modified="2015-12-09" version="1">MKGGVRCFNKEKIELPVLQQYDEKNPREFLDKFRMRYGSLETTSQHQLFKEYLSGSALIAYKALKIEDYNSFKEFAEAWIEHYKPNFSNKRREIILEQLLINNSRKADSPLQYVNCIQGWINELSELRHLSDSEIAKYWLAAAKGLQRYDEIFDYYFSPNRENSLLKAKVLAALKKETQRDFNNKKENTGPSTIEKDFRKEVNMIECDKPSDNSNADNKISYVCRLVLNGKENLVPCNIQGKESNCLLDSGAEVSLITISKVKQMDPLPIIKKNPRIIVRDVQNQPLHLLGSTELLVEDILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEU7</accession>
    <name>A0A0N5BEU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000451600.1">
        <property type="protein sequence ID" value="SPAL_0000451600.1"/>
        <property type="gene ID" value="SPAL_0000451600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000451600.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18888" checksum="BA58AE0ED688AB0B" modified="2015-12-09" version="1">MATHLKNLNTLSLLGIESGDITLKEILELFPKIKVLEIFFKKSFKDSQVLDFLKGQKLGDGSYKFAWPKTILLNIFTYYPNEEEFYDFQMVERTISRKSGQLTFSDDGSYRAKPCILRVTLQQSPGCYDHLRVFKNYKYYFDVEIDFYQFMLFKFELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEU8</accession>
    <name>A0A0N5BEU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEU8"/>
    <dbReference type="WBParaSite" id="SPAL_0000451700.1">
        <property type="protein sequence ID" value="SPAL_0000451700.1"/>
        <property type="gene ID" value="SPAL_0000451700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000451700.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25553" checksum="1661DF1912FAD3EC" modified="2015-12-09" version="1">MFSLSGSEKPVVLKKASNGKTSCEIVFDCPELVTMRFKIEYRSCLPIDILLEGLSNFRQNEIDYLEIIGTCYNKCDFTNNWDKFIKLISYFKRVDITSNFIMYGQGFYNSMKRLSSIDNNSKFGFNLKVNIDSSFWNEIDQPICLKIKFLCILDIVDERTGGYVDEDMTNTICKKISMMHELETLIFRFRKTYLGVNFANFIQSASRNLKNIQIQIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF10</accession>
    <name>A0A0N5BF10_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BF10"/>
    <dbReference type="WBParaSite" id="SPAL_0000458000.1">
        <property type="protein sequence ID" value="SPAL_0000458000.1"/>
        <property type="gene ID" value="SPAL_0000458000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="261"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000458000.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="59199" checksum="C60E7830480A8927" modified="2015-12-09" version="1">XEEVIDGKKHYNIISFYSRALSKAEQRYPAMELECLAAVSTLQAMRYQLWGLPIQIISDNKQLCSLLISGNLSLRLLKWSMLLGEFNISNIVYLPGSKNVIADAMSRVIEHCDIPDDEEFPTPILSVCSISELTNKIPNECEWYRIQNTDEIFLELRKNVLNKSTTPKLTDEFGKKQFEIGKNGLITYNKKIVLNKEYATYILKMIHETNHINAESMCSQFNRVYYAKNRTVLALNIVRDCKTCFHNKEIITNRKVIEKEKVDKPFELGSMDYGYSECYKQYFLLLRDGFSNFAYATWVKNFSSKVIIQFLESIFQNYAVYKNIKCDNQTGFKSNEIRKYLESKGVNIKFSNSYEKWSNGKAERAIKSIKNHLKIFYKLNKSKGIALQLAISKSRDTIYHHEKSPRELHFNTSNLSSINTIRNQNTLNSMRYIWSRGNYKVNDEKKDCDIIAQIGKKTFIIKDKEKFIKTTLVNVGKEKIPDHEKKELAKKVQPFLRTENFFSKEGNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFG7</accession>
    <name>A0A0N5BFG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFG7"/>
    <dbReference type="WBParaSite" id="SPAL_0000473300.1">
        <property type="protein sequence ID" value="SPAL_0000473300.1"/>
        <property type="gene ID" value="SPAL_0000473300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000473300.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9650" checksum="9EE989F2D8649EA5" modified="2015-12-09" version="1">MASLDQIFLTVDKSFAELTEDLSRLIKVLTFCIPFIVFFLGLLFLFLVFIILISFYLQCMNYKNRVVEYNPELGIKDPLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFJ3</accession>
    <name>A0A0N5BFJ3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000475900.1">
        <property type="protein sequence ID" value="SPAL_0000475900.1"/>
        <property type="gene ID" value="SPAL_0000475900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000475900.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="58356" checksum="ED0CD359930D3EAF" modified="2015-12-09" version="1">MALPPFRARNLDPNKRVYVFMENELDDASDALGWRYLVKLPTGMEEDEENETHIQEAINNKQAYTLGSTNDQLTTLIPTRPTEEINNDMYASLYKVVDDKVLNEEEYIRLPIPYLFSNPITMYDADEEDYEWLEKRPYITIDELESIIETLENESTDITLCLPGNAENRLKHMTPGIVGEVYDLWLHKRTDCNLKGLRSLMPRVKTECGKENHTSVNPYVCFRKRREKMQTRRTKKCGEINYFKMLYLRQNIKIFDRLLKKMEEREKLKRRIIDENENIFNMRLSFDLNSQSVISKENLPEKAIVDCVMKTIINDIDEYFIKVDAKGKKNKDGNRKRSCKWDKFLKGADYRKTGGELLFNNRYRNLSEINIEDSDSSNEEIDDEVMDGFEFKRKRGVTYHAPTSNTLRLDSSNCDDVPFHGDAYNHRNRFYPFTFSSKINGGTFTRMVRKVLGRCGQTFLEYINVDCNENLPKKLFAVHNEQFQVNFDLPSSKNVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGA5</accession>
    <name>A0A0N5BGA5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGA5"/>
    <dbReference type="STRING" id="174720.A0A0N5BGA5"/>
    <dbReference type="WBParaSite" id="SPAL_0000501400.1">
        <property type="protein sequence ID" value="SPAL_0000501400.1"/>
        <property type="gene ID" value="SPAL_0000501400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000501400.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16411" checksum="3DEC17F6B1B6AC32" modified="2015-12-09" version="1">MLPKKDLRVIFLYEFKLGRNGAEAYQNIVDAWGEGSTSKRTDDKLRCHISKIILKKFGELKYEALPHLPYSPDLSPTIFNLFKYLDVFFKDKLFKNRDSAEEAFTDFIKSKKPEFYKTGIQKLVERWEKCVNSNGYYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIC1</accession>
    <name>A0A0N5BIC1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIC1"/>
    <dbReference type="STRING" id="174720.A0A0N5BIC1"/>
    <dbReference type="WBParaSite" id="SPAL_0000570500.2">
        <property type="protein sequence ID" value="SPAL_0000570500.2"/>
        <property type="gene ID" value="SPAL_0000570500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894648" evidence="6">
        <location>
            <begin position="18"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="348"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000570500.2"/>
        </source>
    </evidence>
    <sequence length="650" mass="76680" checksum="9A7045083688755D" modified="2015-12-09" version="1">MKLILLLIFFKLPSTYQESPSSYGNKNNFKPSKNISLYPGRIYLDKIKFFDGTYTKINEEKNPNKYQTEKTNDDEIKIIDLNKETTMVDSIANLEDINSLYKNITTEDYYNLINSIKGNENFNPLKRLVDDLTDPEYYEKSVHPRIDFKLPTNINVSMSLYQILEVNERLQSITVNVWMVQDWYDEFLNWNPDDYSGIQQLILPYDQVWTPDTYLYNSESLEQKKTESLMNVIVTANPNSSSGAHVRLMFPAIYKFSCSMSVKFFPYDQQNVSMIFSSWTHDSSVIDYHYTTEDVNLKNMAPNDEWEVISFKFTRIPVKYKCCKNPWVMLYAHLFIKRKPLYYIINLVLPTSIITVVAVTGFFTPSSSDSERNEKLYLGINTLLTMSIMLLMVCNKMPSTSNYVPLMGWYYMCIIFIIVFGTFMATLVLFLHRKKINVSPLPKMVRKILMHNYLWWIILEPPIQLVEIWMEYGFVSEKRLSIQQIDTELLEFLEELAEYNDNDNLSIESSNFFKEMSRRLKEYDVYEYQKRMDKITRQYALLLKAKQQKNFSNRAITNFGTLQSTVNGASIKTIKSTSSNYYCNERRPRANKMFQLNHIFIKKQKLARRSALEWEYFSNVLDRVLLVIFTLISLSFFMLLAFFDHVHPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK41</accession>
    <name>A0A0N5BK41_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Equilibrative nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK41"/>
    <dbReference type="WBParaSite" id="SPAL_0000630600.1">
        <property type="protein sequence ID" value="SPAL_0000630600.1"/>
        <property type="gene ID" value="SPAL_0000630600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF80">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000630600.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49438" checksum="0C841FAEA9E82C9D" modified="2015-12-09" version="1">MTFAPPKDVYNTVYFIMMLHGIGVLLPWNMLTTIAPSYYIDYKLTNYYENGTISYQPSVAKDFFSYLGIFAQFPNLLLNLINLFLRIKGDLTKRVLWSIFILGGGIVFTIVFIYIDTSSWIIAFFWMSMGSFFVINGASGMYQNSIYGIAAVLPMEFTNSVILGNNICGTFIAVINIITIAGSNNPKVAATAYFVVSLAVIVICFFSIPLLKKLEFYRYYDDLSKTSIQNKNGDEEDAKISLSVYLEVFKKGWQQMINVFLVFFVTLTIYPTILSDIVPAKYHDNDWTFFISKKYFSAITCFLFFNFFASAGNMIAGYIPMKYKRLTSIPIIIRLLFIPFFIFCNFRPERRTWDVVFVNEWWYIIGNIIMAFTSGYFSSLSMMYAPQAVDPSKSHIAGMMAAFFLISGICAGVGFTFFVTYFTESLGPLKPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKF9</accession>
    <name>A0A0N5BKF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuronal calcium sensor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKF9"/>
    <dbReference type="STRING" id="174720.A0A0N5BKF9"/>
    <dbReference type="WBParaSite" id="SPAL_0000641600.1">
        <property type="protein sequence ID" value="SPAL_0000641600.1"/>
        <property type="gene ID" value="SPAL_0000641600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF172">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000641600.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24130" checksum="A5394A06037701AC" modified="2015-12-09" version="1">MGKNNSKLKNDSNKKKANKKLSEEELNELESKTYFTKRELKKWYKDFIRDCPSGELKIDEFQNIYKQFFPNGDPTKFASFVFNVFDNNGDGHISFKEFISALSLTSQGSLDEKLDWAFSLYDVDKDGFITKAEMINIVDAIYSMIGNMLELPKDEDTPEKRVEKIFATMDLNYDGKLTRDEFKQGSKNDPWIVQALTIDMSSEDTNVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKL7</accession>
    <name>A0A0N5BKL7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BKL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000647300.1">
        <property type="protein sequence ID" value="SPAL_0000647300.1"/>
        <property type="gene ID" value="SPAL_0000647300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF477">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="156"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000647300.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39494" checksum="0BCB87E70B0A45ED" modified="2015-12-09" version="1">MSDPKATKKANELGGQNEGITQKYNPSDKLSKLPHRTKDEIKKWLCDMVNRLVHEWRPALSTVLFSEEELIELCYRARETFWMSKTYIDVNPPVIIVGDIHGQYEDLLAIINFNGFPPFKNYVFLGDYVDRGPFSIECITLLFVLKVLYPAETTLLRGNHESRPVNMHYGFFVECKKRYSPALYDAFQWAFNCMPFCARVGKKILCMHGGISEDLVDLRQLDRVERPCEIPDLGVLADLTWADPDVGISGYEDSPRGAARVFGKEALEAFLAKHNLELIVRGHQVVQDGFEFFADRKLVTIFSAPSYTGSHDNVAAVMNVDKQLVVSFTLFKNDTEERKTKEKAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL05</accession>
    <name>A0A0N5BL05_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL05"/>
    <dbReference type="STRING" id="174720.A0A0N5BL05"/>
    <dbReference type="WBParaSite" id="SPAL_0000660800.1">
        <property type="protein sequence ID" value="SPAL_0000660800.1"/>
        <property type="gene ID" value="SPAL_0000660800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894439" description="protein-tyrosine-phosphatase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000660800.1"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116780" checksum="2C3D2C61EBE84471" modified="2015-12-09" version="1">MSLNYPYIKYICLVLLIFSEIASVKGSIFLDWTTNIPDDLNVLHYQLDYTPNVGEPPPKSIFPIRYTNTVINNTLPAHDYKISLVAVLADGANIPLINKYIPSSPYPPIYRNISTAPTEAIIEYEPPQGQAVTYYIEYFPSNNEDLSNYVETQATIVRLKGLLPKTLYIIRLYSVYKGMPSDTFNEESFMTKGIQSKGKENEKVLFGIKTLPPFFKPIQTTPQKNGIDQSQTLSPSFFVQQAKEFFATSTTPQPPPATLKPFSFDTLNFKKEFSQLFTVPSSPYEITTQQSTILASSSTLNYPDFTKPDYFNPQTNNWNFKTPSKNNNNSTSNLLFTTISSSSDTSTIPTITTKTLTTKMLTSSLPLQTTIQTTTNTVKSEEIIDLENVKFNNKSTVKFNKVSSSNNSMNHQNEVKKVDENIQEENEEDIQEENEEDIIFEDKSEFLSSTPTTTTTLEPLAIGNTVTFQLTESGELNLEKDGDNLIVKWENPETILCDTYIANLTYLTNNKESVIETTNDNEVKFKFPEVDKALITIYCSYDGVIVNTWLAQRISDFTKPKPVEYFKVTSISTDEFYLSSVNLTWNNIYKNSDKYYNIMISYSYGKTSQNKKTVVVEQGNYVVIDKLNPATLYTFTIKNISSEFSNLSSKARGLRQLTPPVITSTVYPGQISSTSININFGESDPEHLFDSYELIFVSSTKNVTKSVKKDEEKSFTFNKLIPGKTYTFILYTIYKSIKSRPVISKVTTYPLKVSKLYPILGAGYASLYWENENIGCSTTKYRLSYVTETKSGDRKTATVLLKDVTKHRFEELDYDLYYTFTITIIMGEGNAEAESESETITVRVKGTLKLRMRELNVAFDNDRSFNTDTNGNVDNYAIIVTENLSSTEDEYDLKTWFDVKAEEKWTSYRASPSTYNPFKNGVKKASFVIGEEECDKRKLSEPYCNGALKSNVDYYVKIRAYTERNVAIETEWVSVHGTVDEDSPKEVTKRLPCHMYLNGCPRNHSSGRFSVKVNQINIIIMILLLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLA9</accession>
    <name>A0A0N5BLA9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Viral A-type inclusion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLA9"/>
    <dbReference type="STRING" id="174720.A0A0N5BLA9"/>
    <dbReference type="WBParaSite" id="SPAL_0000670800.1">
        <property type="protein sequence ID" value="SPAL_0000670800.1"/>
        <property type="gene ID" value="SPAL_0000670800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029512">
        <property type="entry name" value="CCDC154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="759"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000670800.1"/>
        </source>
    </evidence>
    <sequence length="815" mass="95173" checksum="A462E6CA9C65B4E0" modified="2015-12-09" version="1">MATKKQKLITQDTAKHIITGIKAPQVYSYQTNDSIPKTKKKDSIVRMENISGIDRFDNYPQMNNIPSKKEQDNSGMTIFMFDFQRNLSNIETKQSLIQNDVNIIKSTLNKHEQEIYSHDAIHRVKQLDSKLKNVQSQVNDLVKTLDKEVTEKGKFNAMHVEAYNKLQDHINSQLSQDKNTFNNAFFDIQRENNALKNQITKIDKEIKDDIKRIDRNLRDLELTSKNLDKEYKNGNMKSVDEIQILKTEVLNTNNTIRNNFNSKLEKLVNEFNTNDKNSKAYVDEKHHLIIEKMDNNFKTLNDSITEVKMDVDKNVNDIMKLFKLTDDKIEKIDKTVLKIEKDNSRNSKELHVNNTTTRKHEEAIIRKLGILENQLYEYVNNANRKMEQLGNDVEEKLTRQKSSDSLLSTSTATLKSSINTPEKIKEELLLIINEKEKLSYNGMLAVEKKFLNIQTQLESFKNEFNKKSKQYSSNKTINQLKIQMGSFEHLLDHVQDAQKKLNQKINQEIPESINELSMKTNNDLKALDNKYTNEINQLQNSITELNKSKKSSSKEMDENNRKRTRHEEIIMNKLLKLEGDLNSYLNLKMKEAEEIDNNINSNKNNSRLGSKHSRTSESTVNPEMDLEKIRAELMTIVNSKSKLTYQATLIVEEKVINLQERLNNFRKELTYKLGTKQLDDPKIIELQKQMESVNSVLEDMEKVQKNMKEKLDDELPSNIEEMSMKMKNALNLIGRRITQEEEERYLAVKELQEVYDSMLMEYKSSFNDIQKKNKKMKDEVDDMKNDLDSCKVAIKKLAESMMVFKSNLENQLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLC5</accession>
    <name>A0A0N5BLC5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 18">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="12">IMP dehydrogenase</shortName>
            <shortName evidence="12">IMPD</shortName>
            <shortName evidence="12">IMPDH</shortName>
            <ecNumber evidence="12 18">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 18">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 17">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="12 18"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLC5"/>
    <dbReference type="STRING" id="174720.A0A0N5BLC5"/>
    <dbReference type="WBParaSite" id="SPAL_0000672400.1">
        <property type="protein sequence ID" value="SPAL_0000672400.1"/>
        <property type="gene ID" value="SPAL_0000672400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000086">
        <property type="entry name" value="IMP dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0129">CBS domain</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12 18" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 12 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 12 18" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="19">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="12 13">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12 13">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <begin position="354"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="394"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="417"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="442"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000672400.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60352" checksum="D109E03C15223711" modified="2015-12-09" version="1">MSGEYYTIESNNDYNNTLNNNKIAMYDELFFISNEKLTSEIDDDGLKIVELFEDKRGITYDDFITLPRLIHFSLDKVNLNTRLTKKIILKSPFVSSPMDTVTEHNVAIGMALHGGIGIIHNNFSDISQQVEEVTRVKRYRHGLVHQPITVDPNATVGYLKYLQSKFNISGVPVTENGGADQKIVGIVTKYDVSFVDSSDYDITKVFEIMTKAEKLVVTYEGATTEMAIKLCNRFKLNYIPMLTNTNELRGLYVRSKILQIDFPNAVYDKHGRLLVGASVSTQDGILDRVDKLVSAGVDVIVIDSSNGASVFQIRALKAIKTKYPVCPQIIAGNVVTVKQAKFLIDAGADCIRVGMGSGSICTTQEVCAVGRAQATAVYNVAKYCRSRDVPVIADGGIKNTGNIIKALTLGASTVMMGGIIASTTEAPGEKLLGPNGERLKKYRGMGSFSAMMANNASCERYLSNRDDNIVVAQGVSATIREKGSLHSLIPLITASIKHGLQNLGTRTIKDLHTDVNNGLIRFELRTISSIYEGNVHSLYRYICLHSQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLR8</accession>
    <name>A0A0N5BLR8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLR8"/>
    <dbReference type="STRING" id="174720.A0A0N5BLR8"/>
    <dbReference type="WBParaSite" id="SPAL_0000686400.1">
        <property type="protein sequence ID" value="SPAL_0000686400.1"/>
        <property type="gene ID" value="SPAL_0000686400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004950">
        <property type="entry name" value="DUF267_CAE_spp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31930">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31930:SF1">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03268">
        <property type="entry name" value="DUF267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000686400.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46675" checksum="6F0843572CEB2197" modified="2015-12-09" version="1">MENNEVIQNFSEEYYDVKSLKKYVFYPIYCFSKKVGIPNFDNKDQTNDCRSKFTKIFLLIIFVLPLIATFIYHLIIGKKYTFLSLRNLENSLISLYYIHSIIALLIYNNLKNTNFFINFIKHLKEYKEIRIVPSFSVERNFSKIKVKLFIFWFLFLVSFIYETILNFVDYEKNSSDDKQYKLSKLYGKSTYIIDALLLFYAKLIIVISATIYSCIYGTLDFEAEAFGKECQEFFEKTPSIHLENINVISLKHTKFFKLVTFSHQIVGKYTDLAVFNCTMMIVYGISVYRFYSSTASDTIYAIQYLLAIFCVIYLEVILLLPICFMDKSLQNIKNTILNNPILWDMKNTQLHGLALSMVTRSDHCEYHGLLMGLIPLNDKTIPLLLIVVVILTSLLGTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLV5</accession>
    <name>A0A0N5BLV5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="17">1.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50820"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:50822"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5alpha-pregnane-3,20-dione + NADP(+) = progesterone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17026"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:21954"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54384"/>
            <dbReference type="ChEBI" id="CHEBI:13601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:47909"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>androst-4-ene-3,17-dione + NADPH + H(+) = 5alpha-androstan-3,17-dione + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:50816"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:50817"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.22" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLV5"/>
    <dbReference type="STRING" id="174720.A0A0N5BLV5"/>
    <dbReference type="WBParaSite" id="SPAL_0000690100.1">
        <property type="protein sequence ID" value="SPAL_0000690100.1"/>
        <property type="gene ID" value="SPAL_0000690100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047751">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006702">
        <property type="term" value="P:androgen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000014">
        <property type="entry name" value="Steroid 5-alpha reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF57">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="88"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR015596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000690100.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27804" checksum="51620F9E3B19509E" modified="2015-12-09" version="1">MLIYGFKASYFKASYGRYNKDAFFKSITLNPRLSWMLQEMPSFVIPCYLIITRYNDYNLYKLFVTSLFVVHYFHRSIIYPMLMKSKNPVPIEIFLSAFTFCTINGALQGFSHLLYIDYNYDNMWTLSTLFGFLLYLSGMFINIEADHILRNLRKKDETGYKIPVGGAFKYITCANYFGEIVEWIGYFIVAKSFPSLAFAFFTIANIGPRALQHHQWYLQKFDDYPKNRKALIPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMJ0</accession>
    <name>A0A0N5BMJ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMJ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BMJ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000712600.1">
        <property type="protein sequence ID" value="SPAL_0000712600.1"/>
        <property type="gene ID" value="SPAL_0000712600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000712600.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26975" checksum="215B977C1A992AC8" modified="2015-12-09" version="1">MCEVSDNPQSCLQIKEKNPSAQTGFYTIYIQDRPTKVFCDMNVNGGGWVRIQDRENDSMSFWNKTWNEYKNGFGNGETNFWLGNELISLFTNSFEKVEMLIQIRGDRLDKVDPMASSNYWSGTFTFNLLPEYTDYAIQLSNATGNATGNGWDDFSYSNGWKFSTIDKINSPYPPCLTQFHMGGWWYNYCGFGSLNGQYNPPIAEDRGYGFSWSITEPTRIVNPVKSRITIREITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMK7</accession>
    <name>A0A0N5BMK7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMK7"/>
    <dbReference type="WBParaSite" id="SPAL_0000714500.1">
        <property type="protein sequence ID" value="SPAL_0000714500.1"/>
        <property type="gene ID" value="SPAL_0000714500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF164">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000714500.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57475" checksum="833B0A62DC93466C" modified="2015-12-09" version="1">MNVFALIIYYFGLISVSKGITTKKLLKIPTKYDPELTSKSLHEYVDLTVDPCDNFYKFACGKWIKDKEEKSKNKTSFHYTNSITNFDYFIKGNIFFFVFIYFLLEALDGRYNNESTAIKNIYNLRKKCIQLSGEKKKNCESEIRNFGKYAFGILFIKKRRIDSEKHGDYIILEDMIKRIKEELKLLIDEKKDIFDKESRDNLLKKLDEMEFTKKIDLLDISSILLMETCYKDIGISGNDSIEEVLKNIESLSKMNHTAESCGYYIFEYEKYLGRFVYFNAMYINVYNVFTTSFNALVEPWFSRYFPSALNYGSIGFVIGHEILHAFDNNFYKYIHGIDHKGELIVTSESIKNFEKKMKCFVKQYGDQKESITMKNINGTLTLQENIPDNGGIKISHRAYMKYLQSIGGEEPKVPGFEGFTSEQLFFISNGKSSCEHTSKEHLEDQINDPHTPAEIRTNLLLSNYKPFSNAFNCKLHSRMNPEHKCEVWTKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP14</accession>
    <name>A0A0N5BP14_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP14"/>
    <dbReference type="STRING" id="174720.A0A0N5BP14"/>
    <dbReference type="WBParaSite" id="SPAL_0000764200.1">
        <property type="protein sequence ID" value="SPAL_0000764200.1"/>
        <property type="gene ID" value="SPAL_0000764200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF34">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000764200.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20481" checksum="8AF3E425380256A4" modified="2015-12-09" version="1">MSEATNTARPAPPSLRGEPDEGGAVDFKKEHEKFIKSLNDVQDPTLKIVFSKFEETTGQKREFLLYGVGGILALYLVAGSAAQLVCNCIGAGYPAYRSIKAVKSTDKDDDTLWLTYWCVFGVFSCFDFFSDAICGFFPIYWLVKVIFLLYLSLPQTNGAIKLYKKYVEPMHKKIEEFLGDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ28</accession>
    <name>A0A0N5BQ28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-C</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ28"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ28"/>
    <dbReference type="WBParaSite" id="SPAL_0000800100.1">
        <property type="protein sequence ID" value="SPAL_0000800100.1"/>
        <property type="gene ID" value="SPAL_0000800100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="181"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000800100.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33207" checksum="CCD8B1ADBFCAB76E" modified="2015-12-09" version="1">MAFSFWSSSHYKTCLIDPVNGYSIHHQDDVKIIGEQDYEKLMIFFTNFIQELATSVTSSKDKISMTVIATAIVYFRRFYAKRSVKEIDPFLLAPTALLLACKAGEYGYLLTNRVIIRCNLMLRKYPFLSEDIVINLDLIQEAEFYLIEIMDCSLIVFHPYRSLTSIIQDAKDYFETEGRVDPLANFSSTTNGWDELVSNTTRYINDSYRCDVSLKYPPHKIALACMLLALIGMGKETYFEDYYEVILTDKEGISDATNEIISMYDTWKSFNENIELPEIFKKVPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQD6</accession>
    <name>A0A0N5BQD6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase peripheral stalk subunit OSCP, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase subunit O</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Oligomycin sensitivity conferral protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQD6"/>
    <dbReference type="STRING" id="174720.A0A0N5BQD6"/>
    <dbReference type="WBParaSite" id="SPAL_0000810100.1">
        <property type="protein sequence ID" value="SPAL_0000810100.1"/>
        <property type="gene ID" value="SPAL_0000810100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000810100.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22467" checksum="627DF6808C788E7E" modified="2015-12-09" version="1">MAAIFKRSLSLSAVANNMVKTPVQVYGVEGRYASALYSAAVKTKTLEVVEKDLQKIKGIYDTDPKFKEFAINPTIKNDKKRDAIQRVGKSIGASKEATNFLALLAENGRLNILEAVCNSFESIMRAHKGELFVEVTSATELSKSHKSALNDALAKFNKGGKKLTINYHVKPEIIGGVIVNLGDKYVDMSMATKIKKYHDALSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQY6</accession>
    <name>A0A0N5BQY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000829350.1">
        <property type="protein sequence ID" value="SPAL_0000829350.1"/>
        <property type="gene ID" value="SPAL_0000829350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000829350.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8365" checksum="DACA72AC60DAE688" modified="2015-12-09" version="1">MSIEKIRCSISKDGIKITSKRVESKSPSPLIKRKSNDNKYSKKYSEILSIKKQNHESRIDAFLREKQIIDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR23</accession>
    <name>A0A0N5BR23_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR23"/>
    <dbReference type="STRING" id="174720.A0A0N5BR23"/>
    <dbReference type="WBParaSite" id="SPAL_0000832900.1">
        <property type="protein sequence ID" value="SPAL_0000832900.1"/>
        <property type="gene ID" value="SPAL_0000832900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="4">
        <location>
            <begin position="513"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000832900.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="70508" checksum="63329ACDEB9F5C64" modified="2015-12-09" version="1">MNTQGFANRQFFTTKPKKEQKPCYFAVGEVLDSPQAKVFVSGITKLISDEILKKIFEQCGEIFKWKRTEGADGNLQSFLFCEYVDAQSSVKAVKFLNNFKLGDRRLIVKMDDKTKKNIIEYLRNSQKPDDLKPIKINEDGLPIFDNDRKAREEVEDNVVAIIRGHYPEFIKMPLAEDNENNKDDGNEEMTKEKKEGSVGRDENEMSGRESVLSNSKKDSERRHGYESSPSESIQSSPVSNSKKSRDNSRRSRSTSKKREAEDSDEEYERRKLKQMMKEKEEDYQKRLRRWEEREERQAKGYKAEEKFNIEMSKKEKKHISKMLRFLEDYDDEKDDDKYYNVHTMNKIRREYDKQRDADLKDREREEREIKELRKIAASHPKNTNESTTISDDDMEVDNHEGKTSKNVVAEQVTPDPGASPSNASCENNDNSTLSDNGEKKPAICLNLNVNNKRVQNEAFDIADDEDDDGPKLEIKKKLKIFEVTHEERMQTMTDEEKAVLIKSIVNNIPKDKVELFKTPVNWELIDKDIVEKKIKPYVDNKIQEYLGDREESLTAFILGKITNQSKPDDLLNDIKLVLEEDAEVFTIKLWRLIIYEIEAKKIGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRJ7</accession>
    <name>A0A0N5BRJ7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRJ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BRJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000849600.1">
        <property type="protein sequence ID" value="SPAL_0000849600.1"/>
        <property type="gene ID" value="SPAL_0000849600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000849600.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="50180" checksum="B349816DC0036008" modified="2015-12-09" version="1">MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGEFEAGISKNGQTREHALLAQTLGVKQLIVACNKMDSTEPPYSEARFNEVVTEVQNFIKKIGYNPKAVAFVPISGFHGDNMLEPSTNMPWFKGWAVERKEGNASGKTLLEALDAIVPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILKPGMVVTFAPQGVSTEVKSVEMHHESLAEAVPGDNVGFNVKNISVKDIRRGSVCSDSKNDPAKEAKSFTAQVIIMNHPGQIAAGYTPVLDCHTAHIACRFAELKEKVDRRTGKKVEDAPKFLKSGDAGIVELIPSKPLCVEAFTDYPPLGRFAVRDMRQTVAVGVIKGVTKSDGDAKATKSAQKAGAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSC3</accession>
    <name>A0A0N5BSC3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
            <ecNumber evidence="13">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Monomer. Interacts with TST. May interact with RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSC3"/>
    <dbReference type="STRING" id="174720.A0A0N5BSC3"/>
    <dbReference type="WBParaSite" id="SPAL_0000876700.1">
        <property type="protein sequence ID" value="SPAL_0000876700.1"/>
        <property type="gene ID" value="SPAL_0000876700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000876700.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26952" checksum="B903DBFD77F192A4" modified="2015-12-09" version="1">MAMIRKPFIFRQFYEAATSTYTYLIGCEKTRDAIIIDPVLETFERDSKYVREMDLNLLYGINTHVHADHITGTGELKKVFPKMKSILSPYSGGKADIYINYDNPLKIGGLNFYFLSTPGHTNGCTTIVSDDLEACFTGDTLLIRGCGRTDFQGGSAEKLYKSITEKIFKLPEHYNVYPGHDYNGVHNSTIREEKKYNPRLTKSLEEFVEIMKNLNLDKPKQIEKAVPVNLKDGITNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSE3</accession>
    <name>A0A0N5BSE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M41 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSE3"/>
    <dbReference type="STRING" id="174720.A0A0N5BSE3"/>
    <dbReference type="WBParaSite" id="SPAL_0000878600.1">
        <property type="protein sequence ID" value="SPAL_0000878600.1"/>
        <property type="gene ID" value="SPAL_0000878600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000878600.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9301" checksum="918C7D5940E9A838" modified="2015-12-09" version="1">MNESYARVKTILTENAVEHRRLAEALLEYGTLTAKEVQSVIEGRPLEKKLMERASRAETIRKTQSSKKLHPGSTAAEGTENFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSI1</accession>
    <name>A0A0N5BSI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSI1"/>
    <dbReference type="STRING" id="174720.A0A0N5BSI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000628300.1">
        <property type="protein sequence ID" value="SPAL_0000628300.1"/>
        <property type="gene ID" value="SPAL_0000628300"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000882300.1">
        <property type="protein sequence ID" value="SPAL_0000882300.1"/>
        <property type="gene ID" value="SPAL_0000882300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000628300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000882300.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10413" checksum="1D2742023C87F977" modified="2015-12-09" version="1">METRLIINKDNEKFKMYSFISNAGENTLEAFHIHGKINCISVEAIENLDKCLGVLCINEPQALSNNFYKVKIAVILSNEIIALEFFCPTTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSJ5</accession>
    <name>A0A0N5BSJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty-acid and retinol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000883700.1">
        <property type="protein sequence ID" value="SPAL_0000883700.1"/>
        <property type="gene ID" value="SPAL_0000883700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894903" evidence="7">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000883700.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21330" checksum="70A3FB8949C7DB92" modified="2015-12-09" version="1">MHLYQIFIFVSLGTLSLTRCSVFPYEEMPSEFRELIPKDLYDIYFNLTTEDRIVILQAVLEKNRLSTFNEAILFIKRRRPVFGKKLEEFVDQLSRSVKVLSNESKSYLKQFSQQFLDVLPDKEEAINFDRYKSFQHKFIKKFNSLDDYSKQEILNAVPIIQLVVDKEALSRMINLLIVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTA6</accession>
    <name>A0A0N5BTA6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DBD_Tnp_Mut domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000909300.1">
        <property type="protein sequence ID" value="SPAL_0000909300.1"/>
        <property type="gene ID" value="SPAL_0000909300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000909300.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32063" checksum="B16296B2DBBF6EAC" modified="2015-12-09" version="1">MNDTIYSTYLLEDSLIQDDFFLPDELLSQGQDEVSMKTCTPDGMGSFVSEEIDNFEPEDMYPEEDESMTSDSENSFQLNIEAEDTPKYPKIDDEVDDLDFVFTKHTTPPDEIAKNKAKILGKFNSGDTEGRVTAILKGKIDTSIDRSFKSTSPADFIFKRNNPNKAALIECESTKKRKGRLSIAERYWKNRVDNEKTYPLEVIKRCLDVVSIHEDDYIITRLTDGSVVPILWRNFPFLAYSKFWRIRKILSESVTDRRKRQNKLYNETRSAAVIVIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU85</accession>
    <name>A0A0N5BU85_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU85"/>
    <dbReference type="STRING" id="174720.A0A0N5BU85"/>
    <dbReference type="WBParaSite" id="SPAL_0000940400.1">
        <property type="protein sequence ID" value="SPAL_0000940400.1"/>
        <property type="gene ID" value="SPAL_0000940400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="4">
        <location>
            <begin position="170"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000940400.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37027" checksum="A392C851D55E8E05" modified="2015-12-09" version="1">MDFNNTNHLHGRKRKNESDYESVDCKKKPSIGFKLLEKMNFEGKGLGKYGQGETKDIEVQNPIGRRGLGHHIHSRIEIDFNESEEVKTINETPKWCPPCSRGFEQSKLIDDTWIIVDKPKEVIEDETKYCSSETLTKMLEGKNVFDHMSDREINFARLRANPYETVKGAFFQNRAAMKMANLDKIYDWLLSGEKIKEDRLNKNPLDLKIDELYRKNYDREQPLFYFADVCAGPGGFTEYLLWRKSFYNAKGFGFTLIGDCDFNLNKFTAASPMYFHPYYGVHRDGDVMNPENLISLQQFVGEGTDGNFCDLVMCDGGFNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUJ4</accession>
    <name>A0A0N5BUJ4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUJ4"/>
    <dbReference type="STRING" id="174720.A0A0N5BUJ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000951400.1">
        <property type="protein sequence ID" value="SPAL_0000951400.1"/>
        <property type="gene ID" value="SPAL_0000951400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="11">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="220"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="959"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000951400.1"/>
        </source>
    </evidence>
    <sequence length="1227" mass="140280" checksum="6498AEEEC8D67189" modified="2015-12-09" version="1">MSTFKVGEKVETDKGKGKVAFFGETQFAPGTWVGVILDTENGKNNGTVEGVKYFTCPDRYGIFMKPSQVRREGEKKSSTRTSIASSARQSKAPSAKASVKSSPIPTPRSMSPSKAASNTSSTNATSKRQSSSSAIKAPSSGSKASNSTATVPALNSDSLQSSCQSNESFVMVKEESLSDLKDNISEESKSSEMIDELEKPVEVQPKTYVPPPDLDEEKEIEYLRSKNVDLEEQVEVLKTKIRDFRPKIHELERLKVTVQKFEENKKQILEQNSRLKRELEDYKHRLEESLRKAEDAETLDATELAARLEELSIDKEIAEEECEAVKAELESYKIQFADKEKELALLKSEMERIDPSPSGNSLQFSALQRQNENLSDAVNKLRDHIAESKVVDAENKKVIEKLKQDIEDLEELTNNQEAEIAELKNMLSDYSEQVDAAAGAEKVVEILTEKNLELEDKLGTLNEQILELEELNEMNEQLLACAKDDESEYLRQLDEKIGEMNVLKKTLRIREEEISKFESTIQQFRSRIGDLNIEIQNKEDELLTEREKLQAKEANEGIPVYESNKVFSELVDLELYRINCEFSQMTSKLLKFFLPDNFSKPGGDNDALLLTVALPRVAAKSMALSDLLIKKYPAVPGGMRREHVTRSHRGEQWGFVANVCYILLNLKVVAKKFEGTLQSCSVDKLASICHLQSEFAHHEKVLDSYFELLKQDRLDENSTIDPLYQIVHHFNYSFEINMSMESYDNKEMLINICAQLSKGFEWIDINRQRILFYLEENYPKENDIIRSFTRIIDTMDEGEKLLIRIQNSIPGDKDILVNSEFMDSIYTVTTSLEKIAKIFVNTCKAGISLMNSFNEFDGLRIAQLAECIHNSVEKISGSIASDKALEHVQSFADTIVAGLNKVSKTMENDGLVVGKIERKTYSALYERGITRKNDSQELESLRWQVTSKDEQIRELSFTLKEKKDCIRNLELKLETHMKNIEGGKGSDKRVELIKKECDEKIRRYKEDQERLLIEIDDLNRQIEIISMEKPSHLVQLNESQSSFDLSLPNNDAIAVKELTGQLDIIRRNYQNLQDSYQYIAYKNCSLEAKQSEAILKELKPLKEANYVAGIYSLKSYNKNKRKREIVDLLLEADKLNAEWSLLQLEGVNPDNRKKYELKVRNYNNRVQALEFRFFTYWGIHHPSEELPKEFRRPKVMNVDDNSLENVKPCGTSKLLEKWCKLNKQSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVK4</accession>
    <name>A0A0N5BVK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVK4"/>
    <dbReference type="STRING" id="174720.A0A0N5BVK4"/>
    <dbReference type="WBParaSite" id="SPAL_0000986000.1">
        <property type="protein sequence ID" value="SPAL_0000986000.1"/>
        <property type="gene ID" value="SPAL_0000986000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000986000.1"/>
        </source>
    </evidence>
    <sequence length="959" mass="112146" checksum="7BDF255D959C214C" modified="2015-12-09" version="1">MNGCTIFNDKLEAFCIDSDQKGKFVITAGSRNITLHRPMITEHCSSCHTKNIKETNVDVLRLNHFDMNDLKIAFTNISDLNVSKITESDIICIYSKSETGRKISDLDWCMGDENLLITTSNDHRAYIWDLREKNPVLWFSSLSKMRHGKFKKSNSGERQLYVAFSESTNIKVFDVRYPEKAYRNVYSHENIINDLQWDNLDYDVVVTVSDDHNIRYWDCNNFNAPIYELKSSLLPPKQFINSPCGKFFTTVTDLYFNQKMSYPSYTIWRRPADNSIFSKDFVDEKIRGGVWQYNDELMSELYFFYLTYSGKFCRRTLNSCHLGTEIESILHAPTIQKCIDIELDERITRYDSETLNSEYLMQSEESITNIGINNDNNIIDVKEVSLPKEIAVVNEYSRYIKIPYFDDNLLNELEALKNISTLELQAAEVNFSRAAVMLVYENIKVSFKLVMEIRFHCDFIINGNILISIYEKDCPLSTKKAEDFLERLQVECNLQKLLPKNKNFIEKMYNKKKIKKKNSTGSSKNSIDYKNTTFLTMVIRQIPKIIKEMNVFPEDFTDSSDSDFCHTDSDENVCNFENIDSANSKTKLLKNLSKSTHFVLDKIDHRTLTATFPFNYTPSSYDRKIHLPRKFGAYFSKSGHFITFGINSTYQAIIITEKINKNDKMNSELLNCDTKFRNQKGNKLHVFHINPREKLPKYRSMFKSLHHFREHLRKQFEKYILSFTWEKHEVTAYHLKLRKFVDMKERNEENNDEYLHTTNYNNKDLYNSMKQCYPFKTHGKVLYSLKESLSINDINKILLQKNDSLVLIKDYEREKHINICENNCVHLIDNDITQILSHIESRMLLNDSQMMSVWNSMKGELLKIMSQCTKGFKSEFTTEHSCKMAPLKFILQHLITSSDYHSVTLLSIILSRICVLKTKNVPLNSNETGLSLPLSIPSRSSYLSNYGYYRASIYYNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVT1</accession>
    <name>A0A0N5BVT1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVT1"/>
    <dbReference type="STRING" id="174720.A0A0N5BVT1"/>
    <dbReference type="WBParaSite" id="SPAL_0000993700.1">
        <property type="protein sequence ID" value="SPAL_0000993700.1"/>
        <property type="gene ID" value="SPAL_0000993700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="189"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000993700.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45976" checksum="3D605C6F0BD4165A" modified="2015-12-09" version="1">MSLSCRQITRLCSLFSTGLKRTGNVVFTVQRNTFIENLNHIRQYHTSGKLLKDYYKILGVDKKATAKEIKKAYYKLAKQYHPDVNKSKDAPEKFRELTQAYEVLSDESKRSHYDATGDNPFAGAGGSSNYGASDWQKKAEEMYEKVYKDFFGRSGMNSGWGRGFAESYSGFDRTSQMVLSITFEEAVRGVSKEINVNVVDNCIRCSGSGCEPPHKKVLCPYCNGSGMITSKQGGFIFSSSCDKCSGTGSYNKNPCMDCEGHGKVVQNRTSTINIPAGIDNGDSIKYRVGSQDVYITFQVSPSKIHVRDKYDIYTDVSISLAQAALGGTVVVPGLKGDTSINIPKGTSSHSRFALKGHGIKRVNDYGTGDQYINIKIHIPKNLTEKQKKALLMFAEDETDVNGTVSGLKEWLVTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVX7</accession>
    <name>A0A0N5BVX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVX7"/>
    <dbReference type="WBParaSite" id="SPAL_0000998300.1">
        <property type="protein sequence ID" value="SPAL_0000998300.1"/>
        <property type="gene ID" value="SPAL_0000998300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000998300.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12662" checksum="C12E2CC022B72264" modified="2015-12-09" version="1">MSLNDSQWIRCNRCIGSLSQMELYLTMCGHIFCLSCLGLDAKQNQADCPTCNSKTHLLEINSKLGQNKTIYFKDPEEESKEVKKKEEKIKSFQRYHFENNMKVMYIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWB4</accession>
    <name>A0A0N5BWB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FFD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWB4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWB4"/>
    <dbReference type="WBParaSite" id="SPAL_0001011300.1">
        <property type="protein sequence ID" value="SPAL_0001011300.1"/>
        <property type="gene ID" value="SPAL_0001011300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="5">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="6">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="3">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001011300.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39155" checksum="029FB104FF741D6A" modified="2015-12-09" version="1">MSGAPTPYIGSKISLVSKLDIRYEGILYTVDTNESTIALSKVRSFGTEDRPTSNPVPAKDEVYEYIIFKASDIKDLIVCETPKPVQSVGGLYDPAILHVSKEAAPAQTNQSPKTSNNESSGEKTKKSTKEADVTKSERVKSVKKETSKPVHRESGGKQSHGNNRNFGSRGNYRGGSRGGRFNHREKLKFDSDYDFEKANEQFKETLSHLTSDLGKTSIHDGDKQEESENGSNIALSDSKSGSEENANKEPCYDKQSSFFDSISCDALEKLKGQNCRPDWRKERMTNQETFGHTAVRALNYRRGRGGFRGSNRGGSNFRKNEGKGGNGRFNSGGKHYYSQKRYNSNKAQAVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXK0</accession>
    <name>A0A0N5BXK0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abhydrolase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXK0"/>
    <dbReference type="STRING" id="174720.A0A0N5BXK0"/>
    <dbReference type="WBParaSite" id="SPAL_0001052600.1">
        <property type="protein sequence ID" value="SPAL_0001052600.1"/>
        <property type="gene ID" value="SPAL_0001052600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="79"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001052600.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40991" checksum="A1FECCEFC9E36919" modified="2015-12-09" version="1">MSFIRKVADLLIKFFSLILPNILGLYNAERAMMIRQFATTLGNSKKSKNTNNYFISNIDINNVACRFYKPKNIKNDCLIIYIHGGGWCTFNARMYDHFIENIIKNLNCYCISIDYTLSPKKKFPYAIEECWNVIEGIASKNNEILKDISTNNVIVMGDSAGGNMTAVITQKASKHEKYKNFINGHVLIYPYLGSWDFNSESFNNYNKYPLFSVLSPRLMAEFILIYLGETANNENVKKILESDSITGNFDSNNNLKNVAQNTEISPILADENILENLPKSLTIIANYDILKDQGIIYYEKMKNSRKSFNSENEINIENFHEIHIFESLTHGEINISKTASKHVASLITNWLIKNNFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY51</accession>
    <name>A0A0N5BY51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY51"/>
    <dbReference type="STRING" id="174720.A0A0N5BY51"/>
    <dbReference type="WBParaSite" id="SPAL_0001071200.1">
        <property type="protein sequence ID" value="SPAL_0001071200.1"/>
        <property type="gene ID" value="SPAL_0001071200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001071200.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54338" checksum="00CB5C1C5BF34717" modified="2015-12-09" version="1">MSFDCNICATNNTASGTEHALYSTKCGHLFGKSCLEEWIRRSSRENRFRCPVCRMHLNYSGCHPIFNAPIELSKSKFGNSKGKHLSENDIVKDYLSGRLKKGSTFFIETGIGRTHKKFIKFFDVHDGYILISAFYCSGVGNIDHDGDTCLHKYFIQIFKGTNILYSEDSGSVPVTAVAFNKFREDAIEFCVGFKDGCLMTEVLSPPYENLRIQNKRGLIKEDSKINSICFLGKEKVVFSVGKCNIFTVFTDNASDKENWLTNVNVELKAVTNLAVINDCVLFGIMEGKIYVFEKNKIPYVLFSEEDTQVTNYTYDSVTNMISIVNSLPYYFIDDREGYMDEIWDEKIVSHKMFIVSKIPKFDSEGCRRETYDINSVGDFPDSSSQVVHEFNPTIISVKYCGRCFAYSIVPNVENGTLQVHFVNDALNIVGRKKIDNLGECIGIFRFEKPVLLLSNVLKIPIVLIFHHGFKTLNFYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY57</accession>
    <name>A0A0N5BY57_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001071800.1">
        <property type="protein sequence ID" value="SPAL_0001071800.1"/>
        <property type="gene ID" value="SPAL_0001071800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001071800.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13413" checksum="C9A116FECFF9A674" modified="2015-12-09" version="1">XKLISTSKFSSAKETKDELRLKVGKGVCYFRISSKNDKNVSITIEQLVLKNGDCETFKSNVEVLVRNDKGAAGINLCKDKSESISLPKLSKEVILVLKSYDDDTFIKFSYQAAPEEVSMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0I9</accession>
    <name>A0A0N5C0I9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0I9"/>
    <dbReference type="STRING" id="174720.A0A0N5C0I9"/>
    <dbReference type="WBParaSite" id="SPAL_0001151700.1">
        <property type="protein sequence ID" value="SPAL_0001151700.1"/>
        <property type="gene ID" value="SPAL_0001151700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="145"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001151700.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34761" checksum="5E3066586D8C4B8C" modified="2015-12-09" version="1">MDKIKNVRNITWREVKSFSESIAKDSVDYISTKAKTVGASFDLTSSPPPHEDYYEKKSVLLDSISINLPNTKVVSFFKAEEFDNKKIYDFLMDVFRIHEPITQSLDCKEEDLEDFFTDIASEYLMDNVSVVVFNDDKELVGICLNSIHHVKECDLKNDIMDKDCYNKTDYSEEYFKNPYQCDKAKKIDLFVSLIEKNYEKLVPNDIKKLLKIDIICVNPSYARLGIAKKLVELSLNFAQEKECHGVMSCTTANGSRKLMEKEGFVALRTVNFTDFKVKDELVFQNLLDKGTGGALMFKNLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1J3</accession>
    <name>A0A0N5C1J3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1J3"/>
    <dbReference type="STRING" id="174720.A0A0N5C1J3"/>
    <dbReference type="WBParaSite" id="SPAL_0001186700.1">
        <property type="protein sequence ID" value="SPAL_0001186700.1"/>
        <property type="gene ID" value="SPAL_0001186700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001186700.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61526" checksum="B82596E131AC91FE" modified="2015-12-09" version="1">MISNYHGYYTTNTTVSSSSYSPSPKEGIDERRGDEGREEGRDGLRDEIIKTQFITREGIYKSQCIAEYIKIATRLPTSPGQAPTNLLTPSVPVRVSMSSMNGENDCRIAFNIGRELFIYEYNEKSQSIDPSKPLDKRIYKGTYPTAHAFNKFIDNEDNCTIIIGFSAGQIQQLDPLQKDIQTSRLFNEDRLIDRTPVTCINWVPFEQSLFVVSHSSGNLYLYDTEITCSLTPPTYSIIKAGNGYTIYGNKNKENRLSLNPLVRWKIGKGSLHQFEFSKNDNEENLLLGTVSHDGFLRIFNYNNKELIIQMKSYFGGLLCLDWSPDNRYIVTGGEDDMITVFNVNEGRIVARGQGHKSWISQIKFDPYMTVTEEEVKIRRGNKFCRTTAVNDDEIAYRVGSVGFDAHIALWEVTEEILTTPFKKNRQSIHYIPHQQSTLLTDDGGSSKKKQQKHHRKVFSFGIKSGKELSNVVCHNDDYIDEGGINLFGTVLCPKMDQVPVMEPMILKKISHDRLTSLIFRKKCMITACQEGNILEWDRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C290</accession>
    <name>A0A0N5C290_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C290"/>
    <dbReference type="STRING" id="174720.A0A0N5C290"/>
    <dbReference type="WBParaSite" id="SPAL_0001210200.1">
        <property type="protein sequence ID" value="SPAL_0001210200.1"/>
        <property type="gene ID" value="SPAL_0001210200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210200.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14447" checksum="F28567F2DBC08870" modified="2015-12-09" version="1">MPQKKLIMEEERVLNTYDAATDYSIYITTDKNIGMDRSKLVRLQRMLAQDKANAPVVSVESKYEEEEAKPKYIRVNIGGVKNRFSSLDIHAIIHDLKTLKGMHVVNVYDIDSKIYLIKLHKHEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2L0</accession>
    <name>A0A0N5C2L0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2L0"/>
    <dbReference type="STRING" id="174720.A0A0N5C2L0"/>
    <dbReference type="WBParaSite" id="SPAL_0001222000.1">
        <property type="protein sequence ID" value="SPAL_0001222000.1"/>
        <property type="gene ID" value="SPAL_0001222000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001222000.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11821" checksum="C79BD7D9DF59D074" modified="2015-12-09" version="1">MEIGIRAGIAYYHAGLNSEERHYIETGFKNGALYALCATSTLAAGVNLPVRRVIINQPKVREEFLEKSQYLQMISRAGRAGYEDESITIVVEEYEERFREYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2N5</accession>
    <name>A0A0N5C2N5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2N5"/>
    <dbReference type="STRING" id="174720.A0A0N5C2N5"/>
    <dbReference type="WBParaSite" id="SPAL_0001224500.1">
        <property type="protein sequence ID" value="SPAL_0001224500.1"/>
        <property type="gene ID" value="SPAL_0001224500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001224500.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26013" checksum="974F6CEA01EFF6DD" modified="2015-12-09" version="1">MSSQEITVQHNHAVIHDKIEKEKILNHIYQEAVENSNQPIVLIGAHLSDLNKEVSINLPSIANITRTICRKRKNKKGHPTISKHAKAEDLILSDENVTLSNGESFLFYDSILNTTNSNDDNCETDDGKNDSSENIETVNNNEDNESKYLRKRQADRKEGQNKQKSDRNKMNKKKVKAKRPPTKKPLGGRPLPPKPLPGKLTTRKTLTKKATTGRPSPARPSKGTMSFTCPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Q7</accession>
    <name>A0A0N5C2Q7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salivary glue protein Sgs-3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C2Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0001226600.1">
        <property type="protein sequence ID" value="SPAL_0001226600.1"/>
        <property type="gene ID" value="SPAL_0001226600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001226600.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="21220" checksum="32F097BBABDC6F39" modified="2015-12-09" version="1">XTGSSSRTTTKKPVMRTKKPSPPPRKPAPTTTKTTTTTQASTNSVPTTSSPFTTIQTTTQASTTPAPTTSSPSTTVPTTTQAPTTLAPTTSSPPTTILATTQASTTLAPTTSTPPTTTQAPTTPAPTTPSPPTTVLTTTQATTTPVPTSPSSPTTTQASTTSASTTVLTTTQATTTPVPTTSSSSTTTSTTTQTPTTTKPKKECRVLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2U0</accession>
    <name>A0A0N5C2U0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2U0"/>
    <dbReference type="WBParaSite" id="SPAL_0001229700.1">
        <property type="protein sequence ID" value="SPAL_0001229700.1"/>
        <property type="gene ID" value="SPAL_0001229700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11 13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015024160" description="Zinc metalloproteinase" evidence="11 13">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="133"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229700.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55150" checksum="821F083B45C340C0" modified="2015-12-09" version="1">MLKTFFIFLCIILFSQIQSLPTINEKNSPNEDQDDKSLTRNTMKTLDEILHRIKEFNSTINHQLYYFRGSKTDTTRKNSIDNEVMENPDLFQGDMILTKTQADDLVENVVEIAKDLGADVSDIFGNAETRKKRKIDMSANFTWDLTIPYTFDNHVKKELIREALNKLQNETCLSFKEYSDFIPQGQAGLKYIYGQGCYSNVGRAHQDKHQIISIGKGCELISTIQHETMHALGFVHEQSRDDRNRYLKVYLENVKPGTEENFIKLGSKKAKRYDIPYDYGSAMHYSSYAFTKNKEPTMLPLNPVYKKTLGSKSEATFLDIKLLNKHYCSNKCSSRITCTNNGYQDPNSCERCKCLKGFTGRDCSEIEKDISCGDQELFADDNNKTLNIKGKKDCVYHIRSKDENKNVSIVVGKVNIYPTYGLFCYAGNRLEVKFESDKTKSGAFVCSKTGETFESEDNYAIIYYKSMEDANYANIYYQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3V7</accession>
    <name>A0A0N5C3V7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4238 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3V7"/>
    <dbReference type="WBParaSite" id="SPAL_0001264200.1">
        <property type="protein sequence ID" value="SPAL_0001264200.1"/>
        <property type="gene ID" value="SPAL_0001264200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001264200.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43074" checksum="7F121064048A1A53" modified="2015-12-09" version="1">MYSIKDGYFGSGKTPCRICLLKTDDFSTTYHEKPELLRTEDWNNIFTQKLKNYSPCKTRYVDLCHDVMLGVIPFGMCVIIHKLIKRIKCIDLYGINKALRKINFKNLNLPPQITKIPSDKKNIRWLSFTASQSYNFLLMFPVIMAYLEEDKLVKNINKGEEIHNQIVDCMAELYLLRKIVKILFSHDIGSDDIKTLDMMIGKHLRFMSTETGRLVYKQHLLTHYPNSIIQLGPLTSVSTLRFESGHQPHKLNSLTGKNRVNEPLSIAKKDAYRECKLYASNYNFEKHGRYVPQRNDNVFLMTSTTECKNLPSRSKKIYKDSDYGKGIRLFHVVDFKNNLIEAIEYDLKFEIEGMLFVKLNILGEKKSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3V9</accession>
    <name>A0A0N5C3V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3V9"/>
    <dbReference type="WBParaSite" id="SPAL_0001264400.1">
        <property type="protein sequence ID" value="SPAL_0001264400.1"/>
        <property type="gene ID" value="SPAL_0001264400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895313" evidence="1">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001264400.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36515" checksum="F68A337BCEF710B2" modified="2015-12-09" version="1">MFSIILILLLSNAAKAPPLSSARTGNSRREVMPSRLRNIKSEAKVNMENNLVCVKMMTYNGRLIAKQGLLDRTIEEMKRLSTDILVITETKLRKNIHEEDTNSIVIMKKGHDTGFIIGSKLKNQVKNIYFSNERIGLNDTLAKLRKDKIVIMGDMNATFSKYDSCENILDKFCIDNETNENGEYILNLCQEYSLSLHQSFLRMRKSRKFTWTKAVSTEYIVQNKVIRKQLDYVITAQKIRKHIKTIYAISQWTFDPCCSDHRALIMEWYIPNSEQQNPKKWKKEKIKIFDEEKAKSLLLNFVDNLVHALNNNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4B4</accession>
    <name>A0A0N5C4B4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4B4"/>
    <dbReference type="WBParaSite" id="SPAL_0001279500.1">
        <property type="protein sequence ID" value="SPAL_0001279500.1"/>
        <property type="gene ID" value="SPAL_0001279500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311:SF7">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311">
        <property type="entry name" value="PROTEIN CBG21698-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895543" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001279500.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25666" checksum="DD4883E31EBC6614" modified="2015-12-09" version="1">MLILHLFLIYFLLAKVVNCKECNVNDFMESQKIFQKFLNLSELADWNHPNVLSYQLNEIYINDYDGSNGLVETCNAYSQMGSYLNQKNISLSDCISTLFILKSVNESSNGLLYGSIINTVEYQCSGGFYNGIAQWNCLKRIFKYKYDDLMKCLTTMLDNYMINSTNVCELIKTSIDCQTKIYRDVCGDNQATYYGCESFNQFIEHLWPMCDNTCNIFDFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5D2</accession>
    <name>A0A0N5C5D2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5D2"/>
    <dbReference type="WBParaSite" id="SPAL_0001316100.1">
        <property type="protein sequence ID" value="SPAL_0001316100.1"/>
        <property type="gene ID" value="SPAL_0001316100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001316100.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="25097" checksum="E4BD7D5E1F18BFF3" modified="2015-12-09" version="1">MVRSLKSTITIISIIFLRKGYTLPVEGGVGSLASKGGSAAALGGGATADNIKRLTELYGIATQIMNIGGEVLSGGRGSGSSYNSNSLSRYSNPYSNKFEGNSIGGGDVVRPTFHGVSGYEPSPTISNSYGGGFLGSKSGYGSPNLGGSSNYGGGPVQSARMSGLEQILQGFLGSSFGSNSYSSSATQPDFFNAKKPNEFESNGYSGKGSNIDAVMNALIRSGAKKSEERPDENRNILSQFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5F4</accession>
    <name>A0A0N5C5F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5F4"/>
    <dbReference type="STRING" id="174720.A0A0N5C5F4"/>
    <dbReference type="WBParaSite" id="SPAL_0001318200.1">
        <property type="protein sequence ID" value="SPAL_0001318200.1"/>
        <property type="gene ID" value="SPAL_0001318200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001318200.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39679" checksum="2C84C93439738B24" modified="2015-12-09" version="1">MLRIMEAIQRRKLIQLLNDEYKQDMVHDGQETTDGVINYTSPPKVIGKQNAINYDNIPYITTPSLTNANKKFTKNITNEDLHKFIESLENKLTDLQRKALRITWKKMSEAPRTSSKGMLCIMEKIFDKMISENPEISNVFYRSAFLSCIEDNRKMKMLKNENNDTEKCPFKKKTIATLRDHANILLDFVNTIMAQMYNIPYKPTYTYKLNSLGCSHAKLTPLGFDRNWFHMLGECFAEVMFSQESIRAFPHAPNAWSIFAVSLTERLYVECKWRKCDNYPKVQRPLQNSYTFSDWSYNNTSNDSERKFPLSSKSMYQIEDKCDDTDQESKIYTGRPTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5G5</accession>
    <name>A0A0N5C5G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5G5"/>
    <dbReference type="STRING" id="174720.A0A0N5C5G5"/>
    <dbReference type="WBParaSite" id="SPAL_0001319300.1">
        <property type="protein sequence ID" value="SPAL_0001319300.1"/>
        <property type="gene ID" value="SPAL_0001319300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="742"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001319300.1"/>
        </source>
    </evidence>
    <sequence length="1197" mass="135922" checksum="242ED6DD36CC9563" modified="2015-12-09" version="1">ATLFEQDCNSDLVGQIATFHCIMRMPKDLVAAFFKHLKKKKEVLCRESLHNWATRNKTSTHQRLVPGKGDKDKNTIVEKKRDTPKIIGPSHWTIKALIGNVKLSTTMYLDSCSGFNYLSMKSWKDLGEPSLDLLDTVEIKDVGANIISCLGALVIPVVLDNIEHTCNDLKWLGFIGCESIKKKLENCTQVRVPKLSMSFDVSEDFKPCVMPFRKLKPNVHDLVKQRLEEECKLGYLRKIPSKQVSNASPIVVVPKSNGEICICGDYTRINKFIIIPEAHDNILIKNILQLRKEDVRYLSSIDLKDAYKQFTIHGKNQELATINTPFRFYEPLRAVFGIASVPALFNNALADLFNPIPDTYRYFDDIVVISKTESGHRAALSQLFQVLEDNNIVCNCQKSQIMVNSINFLEFCISSDGTIQASNKMKGMILDSPTDSTSLRGALVKMSYARLFIPDFAKLAKSLYPKKNKKFCWTDLKEKQFQQLVQAYHQAHSLHMIEDNINTLFIDVDCNNEFVGFVVCWMKGGKPFLLYSNSRVLQGSQKRYSPALRLLLAVSIAAEELESILLYNNIVVYTPSVDIKKMFDSFVSFDECISNDTTFINWEVKKKNSKSISDVPHFLIASKDAECETILDPKLIIDEYKNDYTYKVLKNQDRKKWPICLRKFKTVHEDQGLLFLDHRLFIPSTLHSELLSKLYSPHRSLLHMRRTITMKFIVEGYTRKTEKFLINCKECQTAQKNLNKLISSLPKATFSSERIHIDNMVYGKSKICVMYDSFSRLTKAFFIKSYASKEMIKCVEKWIEEVGTISILVSDNHRPLISSEFDDWLKGHNIYHIRSIPYRSISNGSVERGIQSVRHGLNQHLSLAQTITKINSSIGADKLTNCQRFEMGKANDTSVSLHDKYTVQVTALNGSGWYKVKYDDDDWKECELVSKIGQSCFKIKDGETYHIRASDAVKLSIVKVTGEFKDQQLWNIHNDEVVKEPQDPLESSDAESTTTAAAPLNDDNDPINYLPDRCVNQSEVDAITKDFVDDWIVASDAAEANINNHTSKGWAIVATNGTQVIIQGKKVHGNTSTQKLELEAAVKGLEFLRANSKKGLLLSDSGFVCSSSQCNYNVTAFPDLWSSFQEKRGETRIVHVSAHSKIVLNEMVDLFGKCYAAEIVEKDMEWPCDLNTAVIRSQEFKELLNKLLKDDAADIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C769</accession>
    <name>A0A0N5C769_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C769"/>
    <dbReference type="WBParaSite" id="SPAL_0001378300.1">
        <property type="protein sequence ID" value="SPAL_0001378300.1"/>
        <property type="gene ID" value="SPAL_0001378300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001378300.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57979" checksum="249F6E1BF1697686" modified="2015-12-09" version="1">MSPTKSSISDSLENIHLSSKIYDRESSIEKEVADSKINEEKTQWKSIYIGGLLAFSSNVQFSIYFATIWPFLQVLDPHVTEEFFGFVIGSYSISNIIFSPIFGWWSNRIKCIKVPLYIGISCQLIGNFLYFTLDKLPCWQKEFMLISRLITGVGWSCVSLLRSYAATASTNKDRSRAVSIISGGLAFGITIGPSLNLLFINLGYPGFRIIRNIYFNIYNMPSFLAVIANFCSLLAVKFAFKEKYVGIHNSGTGDKENSNSNLPKYDKVAVSIAFISRFVQMFIVSNLSTISPIIAMMMFNFTKKQTVTAIAYAQGFLGFSAFVVYFLFIFFDIGKYGKFRRNIMMGFGLLIIFHLIAYPYSFIYKNSPKVSQYNSSTLTNISSSTELTGCDISKFDWCDNLPIINPYLYFITYSLCIGIAFPVVNAAMNTLFSRMLGSRRQGTMQGWLQTCGGVGTLTAPIISAFMYQNFGPKIIFIYQIVLGCIVILLWVIYHHRMVPLKVNNKDEEMNVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C787</accession>
    <name>A0A0N5C787_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C787"/>
    <dbReference type="STRING" id="174720.A0A0N5C787"/>
    <dbReference type="WBParaSite" id="SPAL_0001380100.1">
        <property type="protein sequence ID" value="SPAL_0001380100.1"/>
        <property type="gene ID" value="SPAL_0001380100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001380100.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46160" checksum="E96C8526DA707C4F" modified="2015-12-09" version="1">MDVMQVDQSSVSSTLRENVFCQSEYQSTDEFLKFKKLEKDLEHIDVMEEYIKLEMRNLEKELLHAQEEVKRIQSVPLVIGQFLEAIDNEHAIVGSTTGSNYYVRVLSILDRELMKPGCSVALHKYSNALVDVLPPEADSSIQMLRADEKPDISYSDIGGLDMQKQEVREAVELPLTHGDLYKQIGIDPPRGVLMYGPPGCGKTMLARAVAAHTTASFIRVVGSEFVQKYLGEGPRMVRDVFRMAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQSTNVKVIMATNRHDTLDPALLRPGRLDRKIEFPLPDRRQKRLVFSTITGKMNISEEVDLEDFVARPDKISAADINAICQEAGMQAVRENRYVVLSKDFDDAYKVVIKKDGDTFDFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7B8</accession>
    <name>A0A0N5C7B8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7B8"/>
    <dbReference type="WBParaSite" id="SPAL_0001383200.1">
        <property type="protein sequence ID" value="SPAL_0001383200.1"/>
        <property type="gene ID" value="SPAL_0001383200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001383200.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42862" checksum="0783BA7267D16D02" modified="2015-12-09" version="1">MESLQFVSIYYFFDIRNNFLIFLVLTAYFIVIVIFDVISWIIYLLLLVFLIRCRLKDDRVISKEFFTLCIFNGVLDIIFVVEEYVNFRIPQFGFFEDFYEDVLAYSTAAGVCYVYSLCQIIVISLSGITLTFNRFYAIKFPTKYKEFWSGWKLFLLTIWPITVVVPIFIVYCSTKVNFIVDPLSGRIFQNFFDEKVNRDIWSVVIGLHITALIINGVLNIFLIRIIRKEFGSRTNVNNQDSDNRIDLAMSKYAIIHFICFGMIAILETVIVFAFKGGLTYLAYDCLTIYVLAETMMVFFSPYALLILSKDIRKRFFLFLGLGKLNKIFNSSANGLTANNINATHQTRSQKTTNLPSQPQRQNLVENIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C999</accession>
    <name>A0A0N5C999_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C999"/>
    <dbReference type="WBParaSite" id="SPAL_0001448200.1">
        <property type="protein sequence ID" value="SPAL_0001448200.1"/>
        <property type="gene ID" value="SPAL_0001448200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001448200.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15386" checksum="01F2F65E098AC224" modified="2015-12-09" version="1">MRGLVPTKVLGKFTCHGAPEKNVQVVILVRNIWGKQTAISTVRTGLNGLLLMSIPDATFKSKEVLLRIGHHCGDPTPGCQMIFTRPLPSKDRNNRRTSYRRYYQLGNTELGRVPFSQTKVCSNGPRRKMSLLNRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAF3</accession>
    <name>A0A0N5CAF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAF3"/>
    <dbReference type="WBParaSite" id="SPAL_0001487600.1">
        <property type="protein sequence ID" value="SPAL_0001487600.1"/>
        <property type="gene ID" value="SPAL_0001487600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895716" evidence="2">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001487600.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28782" checksum="B45021E0E51364B7" modified="2015-12-09" version="1">MYFYFLLILSYVSLSMEQYDNVIYGYNYPYPTSTSNSMDGRNLNLFSGITGDFLSSMTSALISGMGNGVTETFLPGTTTLNGVYQPQVDLNNIYSGTFYPSRYFPYPSEYSNYERNTILSGNGYENLYKGSLITTPQTSSNLYTMSSSYYPPNAFNGINGPRPLGSTFAGHSNVWGRPIVPIISSKDTTAFNGKFLSTLISKMGYQKGEKSLSTTTTTPLSSLVNQTPKIPTISSTTSPNDKTIKKDNLKKRKKRNIVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAU8</accession>
    <name>A0A0N5CAU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAU8"/>
    <dbReference type="WBParaSite" id="SPAL_0001501700.1">
        <property type="protein sequence ID" value="SPAL_0001501700.1"/>
        <property type="gene ID" value="SPAL_0001501700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895622" evidence="1">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001501700.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39859" checksum="419DEF10BCECB922" modified="2015-12-09" version="1">MIYFKISVQKVLFITLLCVSITNGNHFIYEKTPIELIESARNLGITQRNLMKEFISQKNIIPNSDEETEIINHFLNKCHEYSQKVGYDEEYIKFLESVALSEVDSHPTSESHYHHPKILDLMSLDDATISFLTTPINGMKKILQRQCLINEVDFQCVDSFFGANNHVTSEKIDIIRSSGGFAKLMLDEECPNNGDDLNDYHCIGTTAKEYGKQCSTSLKFYNMTKYDVDHKILNLFASAISEIDKFNDILEKTNDLKERIKIKRDTEILLSSTLKTISQMEGSKCRLFYQLGKCLKSSVTNLCGKDAGRKFEIMIQVGYLRRERFNDINDAFLALNMEPHRSCGNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAX7</accession>
    <name>A0A0N5CAX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA-processing protein FYV7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAX7"/>
    <dbReference type="STRING" id="174720.A0A0N5CAX7"/>
    <dbReference type="WBParaSite" id="SPAL_0001504300.1">
        <property type="protein sequence ID" value="SPAL_0001504300.1"/>
        <property type="gene ID" value="SPAL_0001504300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01854">
        <property type="entry name" value="BR22PROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001504300.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13865" checksum="6B46614A635DC2CC" modified="2015-12-09" version="1">MGKPKSEEKTDKTSKKKFNYFEKKFAHKKRKKVTAAVNEFKNAQETYKRLKKQQEDERERKRKEAEERKEKMDQYYKIKKDMNNALRKRTKKGQPNLGAQVEVLLKKIERKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC37</accession>
    <name>A0A0N5CC37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC37"/>
    <dbReference type="WBParaSite" id="SPAL_0001544600.1">
        <property type="protein sequence ID" value="SPAL_0001544600.1"/>
        <property type="gene ID" value="SPAL_0001544600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001544600.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7559" checksum="6C7CB5E2DE17F4CB" modified="2015-12-09" version="1">MSKKSIFDQLKASANGNFVDKKKRAPKNNNSDKEEDITYKFAGYVLSNPDTGFTISKTQQSQNNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCJ7</accession>
    <name>A0A0N5CCJ7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCJ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001560300.1">
        <property type="protein sequence ID" value="SPAL_0001560300.1"/>
        <property type="gene ID" value="SPAL_0001560300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001560300.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43897" checksum="8A4AD75C1C458CA1" modified="2015-12-09" version="1">MITCYSVNFTENVVSLNYREKRAVIRDEKYRWNRHIFSYSVDKSLRSDKIVLGLVMITKSTCLKFRRTLERQKPDLLYVRGPMYVTYLGKHSKSPHKIYVPGVFTDPSKVARETLRALGLDYEHNRPDRNKYLDVRFLNIPTSLLLLFYKDSPQFVNTFGLNYDYRSIMHFSIGESCKKKKICMRTKERDPLVESVLGKANELTFNDAKLTNLQYCLSLLVVRRSKCKHFGYPLNLKPTFCLCLPYFVGELCETPRKNYEYCRTQNVFFASRKKFETILISKKDCYYFIRAGKGERIRFEIKYLRYRPWNRLCNNFEHIEVRNKDISVSGTMICPKFLPYKFISESNMVIIHTKNSKKSFKVRLSYKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCK9</accession>
    <name>A0A0N5CCK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Troponin T</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCK9"/>
    <dbReference type="WBParaSite" id="SPAL_0001561100.1">
        <property type="protein sequence ID" value="SPAL_0001561100.1"/>
        <property type="gene ID" value="SPAL_0001561100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001561100.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="16669" checksum="B30782E9CD27B76E" modified="2015-12-09" version="1">MSNITEEEWENYKKRVNKIEAERARRREEEEVRRLSKEERKELKDTFKRLPQGAQNYLKDRKRTNKQKAGQEVNKGNQREWHQLHEEEKEEFKRRHQSPRPGENYLQYYHRMEDRKRRIEVKRKRINDNEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDC7</accession>
    <name>A0A0N5CDC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDC7"/>
    <dbReference type="WBParaSite" id="SPAL_0001587200.1">
        <property type="protein sequence ID" value="SPAL_0001587200.1"/>
        <property type="gene ID" value="SPAL_0001587200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001587200.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41660" checksum="B28E9AE0A6A853FE" modified="2015-12-09" version="1">MPNLKPAKEDSWAFQTIGSPFPDAPVKVIGQQNQYVALWYKNGKPIHGRAWNNGGVVECSFPYLKTELKGAHDLGGQIQILQYKGNHLNLGYWYNWIKYSDRFDIENREILRCGDSIPILWKNRPNGAILGYLDNKTEIAKFSHDGICEEVVGPKLSDFLIIVRELKGAPPGCECKECAVKPPPPPTLRVNSNVWRDYRIGDSFPTDGTPLKALGKSLTTADGESVDQYVALWYQQGEPVYGRVWNENGKIAGSFAWHGNDYRKNLGSIQILFELPEAMRGYDYLWVPYPEACASARNPDAPAQPVHVKFAKGDITPAALCLDGGKQILGKADMMNERTEAGFGGKGFIQEAKAVHTCLVLCRKAKPGCKLEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDN5</accession>
    <name>A0A0N5CDN5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDN5"/>
    <dbReference type="WBParaSite" id="SPAL_0001597900.1">
        <property type="protein sequence ID" value="SPAL_0001597900.1"/>
        <property type="gene ID" value="SPAL_0001597900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001597900.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22248" checksum="D720815060A159C4" modified="2015-12-09" version="1">MGTLDDVFYSTNFIFGCLSNIVAISLVVKKRNESQNKYYTFMLFFQFGMAIISTIVLGFLKPHIYAFDDFLVAFSRPLSDPPSNDFLHSSLFGLSVFLLYFNITIPTGLIAARFSIVCTNSGFKRNSIIRVIGLCITLTIIQAFGITFPFSEHVSSDIIINSIKKYNIESDILTESTTVLGRKIVCFFEIIFLMLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEM6</accession>
    <name>A0A0N5CEM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5658 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEM6"/>
    <dbReference type="WBParaSite" id="SPAL_0001631400.1">
        <property type="protein sequence ID" value="SPAL_0001631400.1"/>
        <property type="gene ID" value="SPAL_0001631400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001631400.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25932" checksum="A7F46B92210003FD" modified="2015-12-09" version="1">MIPIFSTDSSLDSNVSVETFETIQLNENKSSLFTKDNFPHTIVNIHQKQNTSNNEKKYYYCFIGLCMIYYIFSSCMLFLSNMRNILSLKSYTKERTDNKDYYISEEVSLFLCQIFFILFAIVVVFNIVNSCKEMLDLVGKYFKKQKFPVNEKLIKYKKYLMRVNYIYVACILTTLVITLLNRSPLLLYAEICYVKTVTIGLVVNYMLICSLFFENYENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CES9</accession>
    <name>A0A0N5CES9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CES9"/>
    <dbReference type="WBParaSite" id="SPAL_0001636600.1">
        <property type="protein sequence ID" value="SPAL_0001636600.1"/>
        <property type="gene ID" value="SPAL_0001636600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001396">
        <property type="entry name" value="Metalthion_4_echinoidea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31369">
        <property type="entry name" value="PROTEIN CBG02325-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00873">
        <property type="entry name" value="MTECHINOIDEA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896018" evidence="1">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001636600.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18241" checksum="637BD47FAFECFB28" modified="2015-12-09" version="1">MNSFQGKLIASFGLFLVLFISQAYLHPLAKIDSADIGNANNDMTLFSNETALVDTLNNPMMSGNSTELARVKRQGGGCGCCGCGCGCGCCCCRPRCCCRCCKCCTCCTTCCRTCCRPCCCGCGCGCGCGCGCGGGMGRKRRSLENLTHKLMDSIASSNQTTAITTADIHSFGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF03</accession>
    <name>A0A0N5CF03_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Girdin-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CF03"/>
    <dbReference type="WBParaSite" id="SPAL_0001644100.1">
        <property type="protein sequence ID" value="SPAL_0001644100.1"/>
        <property type="gene ID" value="SPAL_0001644100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049885">
        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742:SF5">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="862"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1677"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1716"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001644100.1"/>
        </source>
    </evidence>
    <sequence length="1788" mass="206437" checksum="96BEA09B629D649C" modified="2015-12-09" version="1">MADGEECSLFEPQSYLKDRCKKCFKLKSKHPVMENVENNNSLSIHNTTTKSVLNEKKSSKETSLTNGGISRSPGKIVATRTKSDVSNTRTVKENINTLTTSKSEKRRSFNDKGSNEVDENDEDTASLMSYKSAHSKGLSSAKSFESIISNMDTRSMVTAVSGSMDDEDRAVTPTEDCHLINGIMVDDKKDLQREIARLTEEVKKLKSERDRWVNQKRGTVEGSEAEQSLIEFLEERLLEAENTIQDYRDENTVLKCELRELQENVPIIENSIPKEKEMEVKLTTTENLCDELMQENEALKADIRELQQEIEEMQDQYREEEIEEFRELQKELETNAKNCRVLQFKLRKTERLKDQLQAEKENSEMKLKEILSSKGINGVESNVNLKVDQFKLKELESELKIAKEVSVRLHTDLEAAEQKRYKLEDEIFYLKEKVRELQTQNKWREQRNKAEQAAKRASIELTEAALSGNDSAKELRDVLEREIDLREQLKFTEEDLKRTQNKLHDVENENEELLRKLTKMSQIGNCRSRPPITRSASDSLNDDREEKLLTEIQDLKEKIKNSEKKNINLAKKLLEYEIETTKKSHAEAEALAKIAEKGDSQNVDIKNDISRLMVILSNIDKTNEELKDEIHTFTTRPSSPKSPIPGLLNKEKIQLQNQIREEQDKSKKLEGELMEMKQIIAKSDNQKLISIASKVDVLTNKLALANDRYNALVRRASSPTKNSSDTNHIVDALNERILELEGKLSEKKANLFYSANDNKNKQTSGDEIEECCEVLASIEAQTNRIFKQVEKLEPSNKDERRRSLSKDTGAAIVSELSTVTEELKNVHKLLESHKLANPEVFCRKNIDNLEASKKDDGNCDGCKMLVENNENQKTEIEFYKKKNKDLTNQVLQTEDRWTIEIEKQRQQFEKDLGQLRIELDDQKKKYDEQKHLIESFKTNLSEKDKLISEKDMKCIRLSQEIQEKLKQILESEKEMKQWKEYEIKYKKLENIYEMEKEKIKAERSKFKAEMSLLRKRSEETLADIEKLRESHQRREIMWNKEREKLENELNSLKKCLTKRGNDDISECDSISQCRSTASNNNTSIIRVTRPAEQSILNELREKITLSERRNCVLENDLVKIRMEKDEIELEVMKNKQTWNREKDELNHKLRQADKIKAMEIDALQQKFTSRMNIMENTNKTLQTQLVQARRERDHNKEGINQLQKKLENEIKKIEKENSKHSEITAKLVATEKKVNDLEVGLDRLKTDLKLSKDAHAADKKLWSVEKSHILKANSVNGCKDDQANGDRKIAEEALKAGEIVQKQYSEYQKFFKKEVDRLNLKIKQLNDEIKHKENDYGKIIKELKEQIRVLEIDQKNLLQNKEVILSAKEALQIDQERLIQALQLAEVQKLTRKYKLTSIVEQLKFIKDQSQKENKENVEGIINILGGMRDDDSSSGLLLTSDSTFDRVDNISDNLSQNSLSIRSINHFRTFNRITNLDLSHRSYSTDNTNDKGQYDSGINTSYSHRKYDNNGRLHYIPRSFGRSASYDRYGMSESALPNTFERMKSTGTLTDDYDACQNGNCPSRSGSAGTNILYKVRREELAKGTTPSVKAMTMAFESLDTKITSKRGFFSIRKSKSVDNGENKDSKKKSSKIKPAMKNIPSDLSSKSAFADTSTLPYEKSPRGGRNPFKNMGSKLVERVRRSLSRTKPEKNKHQEIEKEEKAKTPTLAEPEKFVDDDDDDNEENGDMDKSCLSEIADTITEDRDTFRSIQECESIAVSINEKPFKASIPTTINSSTLRKVNISRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFJ2</accession>
    <name>A0A0N5CFJ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Triosephosphate isomerase</fullName>
            <ecNumber evidence="8">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5CFJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001662900.1">
        <property type="protein sequence ID" value="SPAL_0001662900.1"/>
        <property type="gene ID" value="SPAL_0001662900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001662900.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19456" checksum="8DF0CC64E2CFCC78" modified="2015-12-09" version="1">MPSQCECFVGGNWEMNGDKESINNISTYVKKHLKNSDEVAVEECYKLQKGAFIREISFGMLNDLEIKQLQAFIDLDVFFDNIVIAFEPVWDIKNGKTATSEQTQKTHLWIRKFLKKKVFSDAATKTRIIYDCSVTDDNCVELGKKKDIDGFLVGGAFLKPEFLKIINTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG48</accession>
    <name>A0A0N5CG48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG48"/>
    <dbReference type="WBParaSite" id="SPAL_0001682700.1">
        <property type="protein sequence ID" value="SPAL_0001682700.1"/>
        <property type="gene ID" value="SPAL_0001682700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001682700.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11238" checksum="29DA1A17CCF55424" modified="2015-12-09" version="1">MPSLPNLNSTETVTSTTLGPISNVTYAYNNGPMFQNDSQRFALFLCCTIIGIGACLYLTLAAIRDHRIRQENNTTYETRNTLPGYAENDDVGRAKERFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGD7</accession>
    <name>A0A0N5CGD7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGD7"/>
    <dbReference type="STRING" id="174720.A0A0N5CGD7"/>
    <dbReference type="WBParaSite" id="SPAL_0001691500.1">
        <property type="protein sequence ID" value="SPAL_0001691500.1"/>
        <property type="gene ID" value="SPAL_0001691500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001691500.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34662" checksum="F02EA5DE0751B216" modified="2015-12-09" version="1">MNENTTTMDQNEKIKNDIDGSEEERCLSQLTQTSKDSIFYSIPPSPKSTSSNSPHEQKKSIKIYPANMPPIPNVVIYPNTNMLNVPNKDNSGKNGTARELNGHERFQYSLNKQQIKASSRVSALLTGFAMVVLVEFQFEDTTPHFLLILLSIITILVISVHLIALMISTCLLPYIESSGCSEDSPHKRLSFYINLAWIFSTCLGLILFILLIAVIAFIKFENVSYLPAAYVAGGILIPVFILFILISCLINRDRTNYSIHRAEVKMASFKNKYIVNMDLESDIQNCDVVSINIDLNDLPNTKETSTKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGZ9</accession>
    <name>A0A0N5CGZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001712400.1">
        <property type="protein sequence ID" value="SPAL_0001712400.1"/>
        <property type="gene ID" value="SPAL_0001712400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001712400.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29002" checksum="18D5774EBAD2E3E1" modified="2015-12-09" version="1">MSFPLNESCINYNDVHYLNLDTVVVGKGRDRIKYLDLEGRWRRSGTSCSAIANAFNHLEKLNYSTLPLSDLGECSLNAIRGPTPFSTKTTLPIKKTPIVIPTEPITVTIEQEVPPSPREIPPYRSLGYGEAHQKRRLSIPAERSRSPSLSSRNASPVPPTYDSTITKGKWSPRPSNKDLGYSSAPSSGYPSPRMQDDQELPRPPHRTQPLSPLPSPRSAYDSEYDSSYLYKASKETNESFQDIRMSLRESRRKLVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHQ1</accession>
    <name>A0A0N5CHQ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHQ1"/>
    <dbReference type="STRING" id="174720.A0A0N5CHQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001736500.1">
        <property type="protein sequence ID" value="SPAL_0001736500.1"/>
        <property type="gene ID" value="SPAL_0001736500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001736500.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49842" checksum="B9A990824F92D40C" modified="2015-12-09" version="1">MREVISVHIGQAGVQIGNACWELYCLEHGISPNGEMPSEAQSGAFDDSFTTFFSETGSGRYVPRALMIDLEPTVVDEIRTGTYRQLFHPDQMITGKEDAANNYARGHYTIGKEIIDLSIDRIRRVADNCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDFGKKAKLEFSVYPAPQVSTAVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPSYYNLNRLISQIVSSITASLRFDGALNVDLNEFQTNLVPYPRIHFPLATFAPVISAEKAYHEQLSVAEITNQVFEPGNQMVKCDPRNGKYMACCLLYRGDVVPKDVNAAIATIKTKRNIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVPRAVCMLSNTTAIVEAWANLNAKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIDSNDAGDEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHT7</accession>
    <name>A0A0N5CHT7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHT7"/>
    <dbReference type="WBParaSite" id="SPAL_0001739900.1">
        <property type="protein sequence ID" value="SPAL_0001739900.1"/>
        <property type="gene ID" value="SPAL_0001739900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970">
        <property type="entry name" value="PROTEIN CBG08587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970:SF1">
        <property type="entry name" value="SERINE-RICH ADHESIN FOR PLATELETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001739900.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="85129" checksum="84B6E01FF409EBCE" modified="2015-12-09" version="1">MHSSSPQPTDTQKTSTLDTKEHKENIQRSKNFRDILSRFQNASNNFNRQYSLRFPSSTSTAILQNINVTIPPTITSGSQTVSGRRPRTARRSTLGISNISTSNSSSNLQHYYQPSLLVESESKGQVGDKDDDISIAENNKTTLPNYNNNIHSHRELDTSLYKEEKQNQNLLSPTIVYENSNQSIFGSVNSMRASSVHSARSPLSPIDGSVSRRRNSYVRDLPPRSNNSESCYSPYHNTYTPSEVGSTASKRSSRRDGLVNDISSQQLPSSRHLSLSSPHTNSLQIKMTPSNYGRSGTPGRENKDIKLSPVPNQRITSRPASVNRLGSYNGNTNILNNGYNSGSDSGCIRENSSSACVSPRSPDYRGPEITLKNKFTQKEAYNEVISSQATTLAMVAENFNEISSNCYPEQRIISKDFLNRLSFYQINFKYSSPVIIKGSIIISDAEIGTGYGGTDVRVTVMISPAAHYSPLMGRQAQVSGFGPVILTEFEETSNNMSNFLNNCGIYQKYYTNYKITVMPSQICCSFHTLAAQFLHHGSNSINPTKYEEHVCFIMLQLLTALKYLQSDGVEKLSTNFKEFLITYHHSDLQTCLQTFEYLPRLFLLKEAIDVNEDESQNVGMCKYAMRALYTLLNHKMHTIIPEIVERSEFSFPLKKCAELLSMDKSSSLSEAKNVLEMAFFVGPARFIQESEAKIWLDINRAHLLNRILGIILTKNERFLDLKEKMHIQFLLSSTPKSLCQSLKLLSYGSLRNIQDSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2M2</accession>
    <name>A0A0N5B2M2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication factor C subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2M2"/>
    <dbReference type="STRING" id="174720.A0A0N5B2M2"/>
    <dbReference type="WBParaSite" id="SPAL_0000032800.1">
        <property type="protein sequence ID" value="SPAL_0000032800.1"/>
        <property type="gene ID" value="SPAL_0000032800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000032800.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39321" checksum="BCCB330C4365CD0E" modified="2015-12-09" version="1">MTTLGVFPTIKRSTKLLQLSFHKELNQTLHNIVEGQDFGHLLFYGPTGGGRRTRIRALLKGIYGDGVSTVKIEKRECAVQSSSKKISYSILSSNCHIELTASGLGSSDKLIIQNVIKEMAQSKQLNETKQKSFKVVVIFEAENLSKDAQHALRRTMEKYSHNCRIIMCVDCLGRIIDPLKSRCLTIRVPSPTDSEIREALCEVVKKDRTACCIKDEHIELCVKRGNGNMRRALITLQTLIQQKGENEVVPQSYIQIVSDIANIIATRQGKSGILECRKKFCELLERCIDPATIYRTLVNQLTPLISEKLHPIIWDMALESEGRCITGSKPIFSLESFVTQAMYEIYISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B488</accession>
    <name>A0A0N5B488_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B488"/>
    <dbReference type="STRING" id="174720.A0A0N5B488"/>
    <dbReference type="WBParaSite" id="SPAL_0000089000.1">
        <property type="protein sequence ID" value="SPAL_0000089000.1"/>
        <property type="gene ID" value="SPAL_0000089000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="140"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="362"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000089000.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57808" checksum="E83F9C6439CF05C3" modified="2015-12-09" version="1">MYQMEHQDIAAVVMKKAQEHIQKHKGDSFIASDVRFEEKRLDRHAATEYLTKSMTIAEKKKRLEEMKAKTSQRLSQSGLLSSSTLKTDTESSVPLSKNNLTIENDNVITKMEISTIKEEVVEKDGASKGPTKDLKTEIMYDPSLQVRKPYTGRKRESFNFFKPGEIVKKAMLARAKSKLQQDLSEIPVLLDEKKVDVPNIEWWDKFILERDNYDKLPTVDDLLSEDFSHIITELVAHPIKKKPPNEPEKEVYPVAYLTKKEQKKIRRQNRKEIQKEQAERVRLGLEKPPEPKVKVSNLMRVLGTEAVQDPTKMEAHVKKQVAERLKKHIDANAARKLSDEEKAEKKRKKMAEDTSLGVHVSIYKVKSLQNPSKKYKVETNAKQCQMTGIVIFTENFSIVVVEGGPKQQKYYKRLMLHRIKWNEEELGEAPSDDKDGPTSSNIIHNECNLIWEGIVLKRNFTGMKSIFAENPKQARDLLEKHKVAHYWDYVINFSNIAVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4D0</accession>
    <name>A0A0N5B4D0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IMP2-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4D0"/>
    <dbReference type="STRING" id="174720.A0A0N5B4D0"/>
    <dbReference type="WBParaSite" id="SPAL_0000093200.1">
        <property type="protein sequence ID" value="SPAL_0000093200.1"/>
        <property type="gene ID" value="SPAL_0000093200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000093200.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18327" checksum="387C7AE0B8FAEAAB" modified="2015-12-09" version="1">MAGKGKFFSEIFSLKFLGRVSIFYLSASAIQQHIGEIVVCRGDSMEPTISSGDLVWAERLSLKFGTLRINDIVALISPTQPDTLLCKRITHKEMEYVENCPLVYRNIIPPGHVFVQGDNRPVSCDSRNFGPVPEGLVQVKFCLRIWPPQKIGWLSNRWFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4F4</accession>
    <name>A0A0N5B4F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Programmed cell death protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4F4"/>
    <dbReference type="STRING" id="174720.A0A0N5B4F4"/>
    <dbReference type="WBParaSite" id="SPAL_0000095600.1">
        <property type="protein sequence ID" value="SPAL_0000095600.1"/>
        <property type="gene ID" value="SPAL_0000095600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF9">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000095600.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21276" checksum="2A7B3ECFC98AA162" modified="2015-12-09" version="1">MAYQQYHPPQGPNLRQIFDNVDRDRSGNISAEELQKALSNGTWSPFNPETCRLMIGMFDTNGDGGINFNEFQSLWRYVEDFTRVFRSFDTDNSGNIDKNELVNALTQFGYRLSNSFYDLLMTKFDRTHTKTVYFDDFIQLCVVLQTLTAGFRDKDTDRDGVITVGYEEFLRMVFSVKMDLMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4K1</accession>
    <name>A0A0N5B4K1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4K1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4K1"/>
    <dbReference type="WBParaSite" id="SPAL_0000100200.1">
        <property type="protein sequence ID" value="SPAL_0000100200.1"/>
        <property type="gene ID" value="SPAL_0000100200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF4">
        <property type="entry name" value="DUF268 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000100200.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="39628" checksum="337B94F6F8E0F2B1" modified="2015-12-09" version="1">MIIVIDNIYFHNFYKIYITTDNPVKDILYPHQIAIVMIVLNASEHNYEQAIETVKCYSWHYNYTFAILSLEKVSEFIYNCVYFDFFFLRHCIVANYAQKYKNQIKYIVFIDGDVGVVNPVHKLENYLPKDQKDILFYDRIFNSEIAAGSYIIRNTLLARSFLKFFADYEYKMPKTKDGRCMKIYNYAKGFDQNMLFVSCMRYILNLMDETPNDIDYHTYEGGKIKIVKKFSKKRWARDAWLTYYTFCDDELFHHSWKQKDIKINKNVFKGRFLANEKICKSSDFLKLWDYDESFKKNCKNINDSLKILADFAYLQYMKELLKSNIVEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5M8</accession>
    <name>A0A0N5B5M8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCDC50_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5M8"/>
    <dbReference type="WBParaSite" id="SPAL_0000137300.1">
        <property type="protein sequence ID" value="SPAL_0000137300.1"/>
        <property type="gene ID" value="SPAL_0000137300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000137300.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22034" checksum="98ABFB42675EF1CE" modified="2015-12-09" version="1">MLERSATADIGRYQREIEELYAERLKKVGPIEKQQIAVQAELDSEEVQEDAVEKYNEQEDENPTHRSTEEENHPSKNHEQQSKDSIIHIESEENKKNAFQAILDMGAKLFYRPTEIDPKSPLLPSPETPKRKVGGQDSTMYHSFNEFRPSLSSTMNRPKVEEQEDQLAHSVMKVMMKAQKQDHEGAIEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5V9</accession>
    <name>A0A0N5B5V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Inward rectifier potassium channel irk-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5V9"/>
    <dbReference type="STRING" id="174720.A0A0N5B5V9"/>
    <dbReference type="WBParaSite" id="SPAL_0000145100.1">
        <property type="protein sequence ID" value="SPAL_0000145100.1"/>
        <property type="gene ID" value="SPAL_0000145100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="199"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000145100.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55841" checksum="B3F327F06701D0C1" modified="2015-12-09" version="1">MPQSLLEKGNQLMEDNFISDNNPLLYSSKKSYSDNGRHLTHRSKLKRQRNRLVQKQGICNISLVNVPMQHRGYFRDIFNTILEIKWRWCIFFFCMSFAISWLFFALIYCIISVYHGDFEHTEEEWKPCVQNGNSFLNIFLFSFTSQTTIGYGYRYPTDACPIIILIMMIQFKLGVICQALMTGVIFAKLARPIKRAATIIFSKNAVICMRNGKLCLLFRVGDMRKSSLAEAHVRLQMIKKHTTNEGEVLPFHQYDMNVGYDLGLDRVVVMWPITICHVINEDSPLYEMSKEDLETSQFEIIAILEGVVESVGSTTQARTSYLPNEVLWGRRFDKLVTYQKDNGAYQIDFGKFHNTINVDTPSCSAKDMDESEIDNTDEIQCNVHDNFSPYITIEDAPDDDISSYPPSGTDSKLTSAGQFQELIDDDDKFSSSKLNTRKYSLSARSTVCFPSSHKLSVRSHRFSTYNPQHFPPYKRSGSVHLGHDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B688</accession>
    <name>A0A0N5B688_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 128</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ferry endosomal RAB5 effector complex subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KLRAQ motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B688"/>
    <dbReference type="STRING" id="174720.A0A0N5B688"/>
    <dbReference type="WBParaSite" id="SPAL_0000157700.1">
        <property type="protein sequence ID" value="SPAL_0000157700.1"/>
        <property type="gene ID" value="SPAL_0000157700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040024">
        <property type="entry name" value="PPP1R21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049372">
        <property type="entry name" value="PPP1R21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019343">
        <property type="entry name" value="PPP1R21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019348">
        <property type="entry name" value="PPP1R21_six_helix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448">
        <property type="entry name" value="SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10205">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21636">
        <property type="entry name" value="PPP1R21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10212">
        <property type="entry name" value="PPP1R21_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01254">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="616"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000157700.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="78943" checksum="9098B871F1790BAE" modified="2015-12-09" version="1">MSELSSPNRISPTFSDSLQFSFSPTYSLPENLSPSEISRLLQTIPSLKQSLFEERSKFEYISNSLIKSDEERRFLLAENESLIFRNEQLIKKVESLQESLRETKKIIDDKKKTFKFGIFGKNKRKGLTPNKSNDDNGSLDPALLEEELSFRVNENENLQRKIDILEHEIEESQQLSNDRIKILEEKNQKLEKELNEILKDREVMKVKMKYYNDNDLKKNLCEKRVSKDVEDGRCIDSFSSNNTHDSPLILEVIDGTITPESGENSDVLTANNNKIDFKDFEEILKLTKNVTELYQHLFVLLNNRTSIYPRDSQLEKLTPSLNHLSTILTNIVNVFEKWNMSSNSFKNINDFMVANIHDSLFDSLKELFCDLKPSMKICIEEENKESLCSPNLQRYNENFIEKMNELLNVVISQPKISCLLNLDNKSPKALPFIEALKISTKKMSDEFVNKILIENRLPTASKKLKNTNDDISKILIGIVDHLTKLEVHIVNRRNDISKLASPIQPLTKRSSSEEEDDNYIDNLNDEDMSKSIEVLKTIIYKLQVENSILKQKIPSKLDNFDLRQIDLIYVHKFKEIVRKLEYFKGCARFYKIQIYTHTIRSVDNLMLKLNNANDFNKRISEELSEGKKALKHLNEDLDTTKYNYDEQMKTMYEHIEQLNNQITEQAQIINALNEGNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Q0</accession>
    <name>A0A0N5B6Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Q0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0000173700.1">
        <property type="protein sequence ID" value="SPAL_0000173700.1"/>
        <property type="gene ID" value="SPAL_0000173700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF12">
        <property type="entry name" value="CC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000173700.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="20959" checksum="C59548DE598DAC85" modified="2015-12-09" version="1">MHSITKSQFRLALILGTIACTIFILRVNADIESSVDLNTETFMDDSEIQVDSKNGSRVKRQYGCPANCYSSCQTTYQCKVYSPTTQCVRGCCCPTTVDLDTACDGGVAVAACINKLCGQGYFCSAKNYCCRCSAGKEAGPCLFNATEKYCPAGYACNTNNYCCPLGSGSALTACSANGVCPSGYTCGAGNLCYPVSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B794</accession>
    <name>A0A0N5B794_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B794"/>
    <dbReference type="WBParaSite" id="SPAL_0000192100.1">
        <property type="protein sequence ID" value="SPAL_0000192100.1"/>
        <property type="gene ID" value="SPAL_0000192100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000192100.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="15078" checksum="4DB4D7C0E5B6355E" modified="2015-12-09" version="1">MDETPNDTNYYTYEGGKIKIVRKLSKKKWARDGWLTGWTFCDNELFHHAWKQNEIKKRKNVFKRRFLSDEKICRSSDFLKLWDYDNSFRKDCKTIYDTIKGYADGAHRYYLKEIIESNITKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7D1</accession>
    <name>A0A0N5B7D1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lyase_8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7D1"/>
    <dbReference type="WBParaSite" id="SPAL_0000195700.1">
        <property type="protein sequence ID" value="SPAL_0000195700.1"/>
        <property type="gene ID" value="SPAL_0000195700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000195700.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10503" checksum="2BECF060E93EB69B" modified="2015-12-09" version="1">MCIDVFGKQFTRDKIDENVRRTNLYYDGNTNYHGSNVVMAYGSIDLWNILGSYTYDSSHNLFSYLINGKAHFADLYPPRETNPVDLPNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7G3</accession>
    <name>A0A0N5B7G3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GpcrRhopsn4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7G3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7G3"/>
    <dbReference type="WBParaSite" id="SPAL_0000198900.1">
        <property type="protein sequence ID" value="SPAL_0000198900.1"/>
        <property type="gene ID" value="SPAL_0000198900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF43">
        <property type="entry name" value="INTIMAL THICKNESS RELATED RECEPTOR IRP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="2">
        <location>
            <begin position="230"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000198900.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="58507" checksum="211E231A8D1ECD29" modified="2015-12-09" version="1">MLLHPLYLLIILYYYTIQIIGIRVTGKWTPTKEPLKFIAKFGFQQLDPLDIPNSMGFVYGNITTKEINENINSEYLLTIVPETKIYSFLNIKDSKVDNTFCSNLLKDISNIAFDSRCFTNGSRGDIFRWVPCPKDKLCIDEDDPKKVLPNYQMTFRIREPVTPEFWYILGISCHLNENCKWIQSTNKKLIDIKYDIWLTNGNPNLRWSNIFRLQLSFDKQRLEDIYGISLFIYIILFVIQRQSLENKGRLNKASIYYKILYNSIICHLISFFLSTLNISSIAWNGNSIEIAIFLSKIFQIVAISYISLFMVKFAQEWRIHISKPKGLSLVTRKIWLILTGISIILYFIKYFLFTTNIYTPGEFETYPDCGLILIRCFYTVWFLYEIRFYIESVTELNQASFLAHFGASTLVWFVYYPIFGVFSHLIAEFWRSKIVVGITTFADTVCVGCLVNFLYQNNSQERILQASLPIDIILSQRTDSLDSADKILLDDYEEDNGGEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M0</accession>
    <name>A0A0N5B7M0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B7M0"/>
    <dbReference type="WBParaSite" id="SPAL_0000204500.1">
        <property type="protein sequence ID" value="SPAL_0000204500.1"/>
        <property type="gene ID" value="SPAL_0000204500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="16">
        <location>
            <begin position="51"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="205"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="17">
        <location>
            <begin position="1468"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="18">
        <location>
            <begin position="1793"/>
            <end position="2094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000204500.1"/>
        </source>
    </evidence>
    <sequence length="2208" mass="250231" checksum="3AAC7EA1662170F2" modified="2015-12-09" version="1">MPDSPKISTHRTSCYPKGISLSTQVNQHNKTFSTVEDFVASFVRDSSKARVIKKVLVATNGIAAVKCILSIRKLLMQLFRDDRIIKFICLTTEQEIQSHAEYLKMADYCVFSPAGSNNNNYANVTEIVEHAVRNNVDAVWAGWGHASENPELPRQLKANNIVFIGPPSTAMFALGDKIASTIIAQTVGVPTIDWSGNGLQLSLCNEINEQVSIPKELYEQATVRTVQEGLESLKRNNITYPVMIKASEGGGGKGIRKCNNDQEFIDGFRKVQDEVPGSPIFLMKCMVNARHIEVQLIGDMYGDVIPIYTRDCSIQRRCQKIIEEAPACIVPQNILYMMQRDAVNMAKKVGYVSAGTVEYMYVPATKEYYFLELNPRLQVEHPCTEMVANINIPAIQLQVGMGVPLNKITDIRLFFGLDRYGDDPLPEEQIKTETNICVIAARITSEDPAEGFTPASGSVEVLNFQSNQNVWGYFSVSSTGKVHEFADSQFGHLFAKGTTRHEAISNMLCALKELELRATFASQVQYLVGLLKEEDFEQNRFNTAWLDARIAAKVQNVQILPLHVNLAFGATVIGYTKIQHAFSQYQSSIERGQILPTSDLTETWQMELVHDNIKYSVLVNRYGPINFVVYLNGSICRTEVRELGNNTLLVTYSDIAYTCYLEEDLERYKVTIGRSTVIFEKENDPSVLRSTNAGRLLRFLKGNGEIVSVDESYAEMESMKMVLDLKVKKLSGTLIHIARPGQTLFPGTLIAKLENQGDQCVPKAKDFEGRMFEWDSIEEERYHSNTRLVNKYDQLKQYCFNVMQGYSVPETVFKEEIKNVVDSLFTVMNDNNLPKNMFEVSFSAVASRIPRTQKDLLEHARRGENFQAQKISEIIYNHLTSVDPKNLEIEKTNFDELLKISKKFLNGLNGNIKMFVEGLLNMYLKTELYFQGVTYDRAVSLIQNQVKESDEVLRMIYSHTKIAAKNMLLVEIISRLDKEVILNLKDTLRTVSNLFNDEAQKLALYAQQTLNSTYKLPIPSVNQFFINNTCNIKTITLYLQSTFCVDYKAITVIGNDNDNVNFVKLTITTDDPLYRYIENTDYANQDTKYTYGFVISNNLETIEDEKDKITSFIQMEMKFISNNLETIEDEKDKITSFVSQFKDLKKIYYIINDSNKESDIEKIKNIILQYLDPNGNEIENIGGCMIIREDNEPVFLNTEFGIYEKLQLSRLPKTAKITSGQSSSFLIFKNENKGITRYFARHLINNLFSDSIGNSKTIISNLTTKLSDIVNSLSGEIRINAFKDKAQVTTVACNHIFICMNMEKQLLLGSKNSNENDEMYKNRIFSLFGLAFKNAINNNYDVLCKSKVTEVEIVLNFSVPLKDNNDQSYKFTQNQWVIGKFVYYNFISTLSSDQCFYIVDKDGNLIPKDLEKVVPLDITIFQNNKYFLQEHRIIENATLQRKRFMASKLNTTYVYDIPGVLAHANFERWRELKSSNIIGYIQALEDMAIARNMKVQNFSARSLLKAYELILNDKNVLEKCTDEKILQDRALNALNNVGMIAWEIDIYTPECYLEPLKIVVIANDITYKMGSFSMKEHTVYAKASEYSRKHNLPRIYISANSGARIGFAEDVKKHLKIQWINEDKPEDGYTGLTLDECSEDVWSQVKYSTKDNVRYLEAVVGKENDIGVENLVGSGLIAGETSEAYNCVPTYCLVTARAVGIGAYAARLCRRICQVENSHLILTGAPALNSLLGREIYSSNGQLGGTQIMYNNGVSHTVARNDSDGLKKILNWISYCPTKKDILIPRSLLHPDNKERMVGFRATKAPYDTRKLLDNSIDFGIFDTNSFDEIMAGWAKTIIAGRARLCGLQVGVVAVETRTVECEIPADPATADSQSKVVMQAGQVWYPDSAYKTAEAINDFNKENLPLIMIANIRGFSDALHAYTQPVIVYIPPYGELRGGAWAVVDTNINKNCIKMFADPESRGGVLEPEGICEIKFRDKDLFAFMDKYDFKLKELNQQLEDIALNGDLQSKKGEILGEIKSRREFLKPVYKTASVKFADMHDTTVRLMRQNAIHDVVPLKNARNYFYNYLCKEIAINRMAKMFVKNVIHNGEDKLIGLEELGQGIEFANNYISYKFGNISDVKNLYQFFESETSEFLAYIKDASLGRVVQNVAEKLNDSSVEKQVGQMSNLMRQMPSNAVMSTLKNILLTNTLSESEKNELLTLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8H2</accession>
    <name>A0A0N5B8H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8H2"/>
    <dbReference type="STRING" id="174720.A0A0N5B8H2"/>
    <dbReference type="WBParaSite" id="SPAL_0000234500.1">
        <property type="protein sequence ID" value="SPAL_0000234500.1"/>
        <property type="gene ID" value="SPAL_0000234500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000234500.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32617" checksum="92B90EF4B366D2A9" modified="2015-12-09" version="1">MEYGTAGLQDSVLKAIISNDRSSNLNTTNVKKVSNSRKNSVVGESQIFDIDDRAKVNLNQIANISKGLAVKSQKMSYDEFEAMPIKYLKMIMDGDIEKLKNELKENENHINGIYLLNNSYTLLHYTVLFQKEKVLKLLIELGADVNSRSNMGFSPLHLASRNQDYNMIDLLINTYNADKYALDVEGMTYADRLFLAEISNNSEHDNLHAKYREIFKNFNDSSYVSKCSKKNTPVVLSKSIKCRSVSQEIKSKKEVESNGVFRKKTFLYGLNKIMGTATNRVRHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B916</accession>
    <name>A0A0N5B916_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B916"/>
    <dbReference type="WBParaSite" id="SPAL_0000253800.1">
        <property type="protein sequence ID" value="SPAL_0000253800.1"/>
        <property type="gene ID" value="SPAL_0000253800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000253800.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28090" checksum="F09AD0BEFA2F5E7C" modified="2015-12-09" version="1">MAQRNVIKCAITILYSKNANKILVGEKKVNTLYLSNSLGFPGALLQPGIDESFDYRKTNLDRISINNTYKSDAYGRSIAAARGLFIESGILPTVEGVPQKSRIETIENNPLLKAYREKVENYPSIFKDLFVAKCLDIKSFIPFTRLQLNTKSDISYDVEVFALPINDLSIGDKISNNVGKFHWVSADTIPGLKEVFATNHSNNFNLPSIEKGSVSKDVFETNKNDSHFQEVISRVNIAFLNGNNSMKSVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B918</accession>
    <name>A0A0N5B918_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Endoribonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B918"/>
    <dbReference type="WBParaSite" id="SPAL_0000254000.1">
        <property type="protein sequence ID" value="SPAL_0000254000.1"/>
        <property type="gene ID" value="SPAL_0000254000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF11">
        <property type="entry name" value="URIDYLATE-SPECIFIC ENDORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026378476" evidence="11">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000254000.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37487" checksum="1B3D4AEEFB8B32E2" modified="2015-12-09" version="1">MLNNILFTSLLLGIFFIVSKEESIPSVPVKDHEIVDLVQKFYDSDLNAPTGDSVLVNYQGHINLQSFNDAAPAPLFKRVDTSIKRKPTFKAYIDLMDNYVTEVGTRESEDEQERNEIDRFLEAVTNTTIGKDFYDFLKKKKHPFVASKRTYFNWLKQLWFGTYSRAKGVPDSSGFEHVFIGEIKNGEISGLHNWYRFHYLESRGQQENFDYKGFIIKRFKTMASVKYSWKGYFKKGGSFFIATSPEYDFFVYTLCFLFRRGSGGCNIEVNGCPASITAYDLHQNNKVYIGSLFPSIGSMNDKCKRYNSGLRKKRSANDAFNLKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9V7</accession>
    <name>A0A0N5B9V7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcyclin-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9V7"/>
    <dbReference type="STRING" id="174720.A0A0N5B9V7"/>
    <dbReference type="WBParaSite" id="SPAL_0000282700.1">
        <property type="protein sequence ID" value="SPAL_0000282700.1"/>
        <property type="gene ID" value="SPAL_0000282700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="68"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="1">
        <location>
            <begin position="146"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000282700.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25236" checksum="086243AE7A7D3930" modified="2015-12-09" version="1">MTNLLKLESTIKECKRLIDLTSNSTVQEKLKELLESSNKELAVLQSNAKLNEGKEQQPGGKVSCRSLTKITNYSYEDSEAKLKLYVTIAGAKEAPAESFEMNVGSDSLFFKAKDINGRDYEFILKGLFDKVIPEECTFKQKTDMVLITLSKAKKEKWSSVLKINDKKKSALKKDYDDSNPQESIMNMMREMYENGDNEMRKTIGEAMLKAREKSAGLGDEPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAS8</accession>
    <name>A0A0N5BAS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000314200.1">
        <property type="protein sequence ID" value="SPAL_0000314200.1"/>
        <property type="gene ID" value="SPAL_0000314200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000314200.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58162" checksum="7B828BC7E01A5266" modified="2015-12-09" version="1">MSGSGSSSNISEISNFQDNTIFSNKIIIESNDNQKYRKDNGKYHISCWMVMLVVCIYSLSSSMFFPITKSLIYQKVCIQQGYTELECRDKKDLSSNYVIQTETNNIFMVVGMVFSVIAIFSSICIGKLSDDVSRKYALMVPFVGLIFSDLILISMANKMEERNQHLFAVSEIIFSLFGGYMTIFAAAFSYISQATCHNLKRRSQFISYLEGAIGLGSTFGYFVGSFFGAYEYSDAYLVILLMHFLCMVLLILAKDMTPEPDDFNKTSVLNETLVERIQDRFTGWKGIFWNEDGKYNFSLFYTTLAFFLSFLALMGSNRILFFFLKNKFYWDAKEFSKFKMPMQSVATFFAIFIYPLLKRTDVKDSTLALIGLIARGFGRLLIAVAWDDTVIYFLVLLEAFNKFGPSGMRAMMAQTVYTTELGRVFSLISVVEAVGNLFSVILFHSLYNYTISFMPELSFIIMAIICIPAIFFLILAEGAIQKLVQRRHERQKLMEPKLIVKVEKDTQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAU8</accession>
    <name>A0A0N5BAU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complex I-MWFE</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAU8"/>
    <dbReference type="WBParaSite" id="SPAL_0000316200.1">
        <property type="protein sequence ID" value="SPAL_0000316200.1"/>
        <property type="gene ID" value="SPAL_0000316200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000316200.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8121" checksum="7F18293678164501" modified="2015-12-09" version="1">MWFEQAYSGIVTTAFIFGAMYMSYPFNKLDTGRMFRRNYCTRDRIHNSKRDHKLTGNQYVLSGLESIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBI1</accession>
    <name>A0A0N5BBI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000338975.1">
        <property type="protein sequence ID" value="SPAL_0000338975.1"/>
        <property type="gene ID" value="SPAL_0000338975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000338975.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15538" checksum="01DE8BE81D52592A" modified="2015-12-09" version="1">MLNKLYNTRKLVPSFLLLDKVCSSLKFGENVDEKELINILQNIVWITKIKIEENDVSALKLIATNLLKVNKHSVGESFNDEKYNIFSIKDKNFISEFDGDYITTKTSASTSTPIKNSISLSSNKPYSTISSNPIDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC67</accession>
    <name>A0A0N5BC67_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BC67"/>
    <dbReference type="WBParaSite" id="SPAL_0000361500.1">
        <property type="protein sequence ID" value="SPAL_0000361500.1"/>
        <property type="gene ID" value="SPAL_0000361500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000361500.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="81576" checksum="21F890F9D4A4E107" modified="2015-12-09" version="1">XPVVSPDTPPAPTTTTTSTKKDESPVKVNMNKKGGKKSQSNDVVPAVQTPPAVVEKAPEAKASNLTGSNKKTKKAVNDVEDKEKVVEKKVVKNVESAPEVEKEQTRSKRSVVPPMKDVNDAFGYLISIDGIPEKCISLITDELDKLRTSVTSCNNKVASFEKQLKEKDATISKLKEVSKKEAENAKILDKLAEKDKIINNLNAKLIDFEEKYNILDDICRTRLTSSGNDAEVSALKSNVSALEKERDFLRKQVDSAQIEFGKLNNDYLNSVSAFKAQLDNCNHEINRLHNEFSLATEKGKNFERMYVDAEGARTRLVSELQMITNEYNQTESQVKELQARLNTFMSRENETLQKSASETENIKAQFESYKNETEKIKAGFENTLSEMKHAISTLEMELDENKKENERLRNSLNEQDNLQQKIVSLTETIQKHKENHNQIAEFSEKAKELKIKLQNDIAAKDQETSRLKDLNKELIIKNINQARELQDLKAELSNIKDKDGTSKNSEKELAEASRRFNEVVKINESIVDAVKKAEENCQKVIAKTEAESAASIKSIVDTTFDVLSQLNNSIPKAPKTSDPTTYKNWLAKSVESLKSKEKEVVEKVVEKVVEKVVVKEVPLSNISNDNKFKELENTSQFYKSALVKLEKKLFEIERYINDFEENEDVLKNKNKGSLVKHNEPSTNLSNCKAHKNEGSDNFAVDKRLIEQKSQETINGDEWEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCL9</accession>
    <name>A0A0N5BCL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCL9"/>
    <dbReference type="STRING" id="174720.A0A0N5BCL9"/>
    <dbReference type="WBParaSite" id="SPAL_0000376500.1">
        <property type="protein sequence ID" value="SPAL_0000376500.1"/>
        <property type="gene ID" value="SPAL_0000376500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000376500.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="70226" checksum="FAD9C25D4A358940" modified="2015-12-09" version="1">MDNMCQIPKFNIWDKSISRYITKKYKNKKCVKTYENNYYTLNNGLLKLNSSTLENSTCFYACIYPIGDNSLTKGKYEKIVNPVILDCDTFHIYCRKPNITIFEDLNFHIRSINFNNQVSSNVSKINQNFVESSKKYNVHIFVIDSLSYYQAKRGFEKSRNLFREKYQSIEFPFLNRVADNSRPNAYSFLMNKNSLNIIDIFGTKRTIINDWKNDDPCNVPLNDTTYIINQYKKMGYITMNAENYWYGGVFNWNNCKSFTKQQADHTLRTFQLANRVISYKLVDRITRERCFGHGNYLFEYLKQFSERYKDKPHLSLVWESNAVHNDINGIMDFDNYFENFFSENINLFKNSFMFVMSDHGFRLGSFQDTQIGKFEADNPYLMISVPIELRNNKQLLKTLKENSNKHISHFDVYATLLDILTEASKTNFENLKEFDLSSIVNFKVKGKSMLRPLQIKNRSCYELYVPLENCLCQFNFTKKYFISNKEQNSLKYAFLDEINKNIINNNLTNICAKRSLNNNYKFNIGKAYLKNETPVYEVKGHVLPGDGIFSGFFNGDFQLINNELLRINSYRSESESCLYEGKNSKYCFCKKLIKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCU6</accession>
    <name>A0A0N5BCU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCU6"/>
    <dbReference type="STRING" id="174720.A0A0N5BCU6"/>
    <dbReference type="WBParaSite" id="SPAL_0000384100.1">
        <property type="protein sequence ID" value="SPAL_0000384100.1"/>
        <property type="gene ID" value="SPAL_0000384100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000384100.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37976" checksum="E90267CBBB92D337" modified="2015-12-09" version="1">MANINYVEGKSLQIVLEIPFKNPSYFPFRLIGDKANGVFVTCITDERSFLKNGDIFLYCENIKLSGLSCNQVYSVIKYFSLKNDGTINILIWRNSSKYFENRMKRHWTVNEGLNLVNTQFIAKQSHNHYHENEGEEGKEEEDDEGEEKGMLLMEDKNINNERNNNNNDSDKMLIDNNVFLYHQSNFNNNINDVMEDGTKSSEGIFDEKQQQLKIHSYVVVFDEAKCKTTTLIQSKKKYFSDIFNKAYSQNTRFWMCPKCKYHVRSRRLHTIKHDWISSARRLLPHSASNFFELQRFNDKEDDEEVDGDEDDNISSYEEYSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDG3</accession>
    <name>A0A0N5BDG3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 12 member 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDG3"/>
    <dbReference type="STRING" id="174720.A0A0N5BDG3"/>
    <dbReference type="WBParaSite" id="SPAL_0000404900.1">
        <property type="protein sequence ID" value="SPAL_0000404900.1"/>
        <property type="gene ID" value="SPAL_0000404900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF53">
        <property type="entry name" value="K+_CL-COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="173"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="455"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="867"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000404900.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="127026" checksum="3758C899AD57737F" modified="2015-12-09" version="1">MNTNSFNVDEENQENVPVNHLSSNRVPPSIRKKMSLNSQQHLYSENKRFMVKQLSKSDCHLNGISELPCTIQRAESSQTECLIEQQGTLNVPISPNSMSSPNDGARNLFSWGGSIKRTNTVTGGSTNDHNLALYEDQNATFLSAYFRAYTTPGPSERAHSKKGKADLGVMLGVYLPTIQHILGVTMFIRLGWCVGVAGIGQTFLMLFVCCLCTFLTCISISAVATNGVIESGGAYFMISRNLGPEFGSAIGLLFYLANTVATSMYLVGGVEILLLYIAPGLTIGGPEVQSDTGLFGMMTHNLRFYATILLILEFCIVAMGVKFVQLLAPVSLVTVIISILACYAGSIEKTLNPDMGPYVCKIDNHLLVSKMYMPEGVGLDRVCEFCNMNNTLLMENICKNETCLWDMNGLKCVNGFPGFTSSAMLDNVGPNYPGKNEYTHGSEAVINAEIFQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPGRSIPVGTISAQLTTSFIYFSLALCFGAVIDGDVLRDKNGFSLNGGMIVASLAWPSDWILLAGSFLSTFGAALQCLCSAPRILQGIAKDDVIPILSVFAKVTKNNEPFYGLILTTIIAELAVLLGAMDSIAAVVDFFFLMCYAFVNLICALHSILGAPNWRPRFQYYHWSLSLLGAGLCFFIMFSTHWDYAIISCLLCTIIYKYVEWKGAKKEWGDGIRGLALSTAQYSLMKIEDKAPHPKNWRPQLLVLHSMPWSKELVDIRYLNLLHLASQLKAGKGLTIVTSFVRGDPISVEDREHANKVRARMEFDMNSLHLRGFAKTLLYGENQIAGSLSTLIQSVGIGGLKPNTLLLSWPIRREDIDRSLDSEYLTFTDKIHIGAAMNMSLIVAKDITDFPTTTKMNGYIDVYWIVQDGGLCILLAYLLKQHRVWRHCKQRVIAVAQKDDNNTKLMKDLQNYVYQLRITADVCVVELSDPTISKHAFERTLLMEERTKFQKELHQQKIEASNNSNGFVNISLADTQSQSSKIVDETVDTMDDSVTSEEIKTDSSDDAKTDENNGEGKTNKGKKTATLAISDEYEKNKKLRALDRKKVHKMHTAVRLNELIQEKSGDSSLILLNLPRPPHTREGLDDYIHYMEVLSDKIPRVLFVRGTGQEVITTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDI2</accession>
    <name>A0A0N5BDI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDI2"/>
    <dbReference type="WBParaSite" id="SPAL_0000406750.1">
        <property type="protein sequence ID" value="SPAL_0000406750.1"/>
        <property type="gene ID" value="SPAL_0000406750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000406750.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8897" checksum="3F556E731A0D5BC5" modified="2015-12-09" version="1">MNIRELKKIMLFVLKYITFNWKNQLKKTNLKGYHKLFFNCLKLYAESIYHYKIFDIFKILSFMLLPLLMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDP0</accession>
    <name>A0A0N5BDP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDP0"/>
    <dbReference type="STRING" id="174720.A0A0N5BDP0"/>
    <dbReference type="WBParaSite" id="SPAL_0000412300.1">
        <property type="protein sequence ID" value="SPAL_0000412300.1"/>
        <property type="gene ID" value="SPAL_0000412300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000412300.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37544" checksum="CA10A1810A877A31" modified="2015-12-09" version="1">MESFPEDIQEIIIDHLFEMGEHASKVTSVMESSEKPKLFRVDGILQQPFVSEKNLRSARKLIPRDDDVFVVTTPKSGTTWNLFICLNLLRVDYMKGSQEMITDVPFLDSFSSEVLDLFPIQRIFKTHFHYDWIPKSKKAKYIYTVRNPKDVLISYYYHVRNMKINEWENGDFNVMFDMFLNDEIESGGYFMHVKSWLPHIHDDNVLFLVYEDMCKDLKGNIIKIAKFLGGNANRVLEDPKLLDEVVETCTFKSMHDKNELFSSQITMRSKTFIRKGGSKNWKKYLTKEQSDLIDKKFNEYFKGTILENLWVEEMAWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDW8</accession>
    <name>A0A0N5BDW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Negative elongation factor B</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDW8"/>
    <dbReference type="STRING" id="174720.A0A0N5BDW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000419600.1">
        <property type="protein sequence ID" value="SPAL_0000419600.1"/>
        <property type="gene ID" value="SPAL_0000419600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000419600.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="72714" checksum="94A37B8427895E19" modified="2015-12-09" version="1">MSSDPFSYSNELERRQLISAKSISKARKNRDIKETIKFVQKACSINVGAPLDPIFQMLDYHGLRRHGIHEQIFKALEEKMIQTIRILGSVRCYESQAKIEKILSRTFDLHKIPSMRPIVLEVLKFAERVDEKYLPEIVENKDLYEACCVTVKQQIWYSNLELFKEEVFKIFDEYIKKKEKVVLYLDSNALNFFNFETSRARKKWKEVVTLGEMAGDSVELYNQLMLLIQQRFMETGCYHYCSLKVEVMVVVFERRQPLDEETVVSQFACSLDAYVRDRQLESQAIAKIRSIFEPSKQNPKDPTFRSLNELEFFAEMAMIACDPHITHFICNYIIKIIYENAATKHKMPRDQHVLHVLIKLLHLGSCAHKAVTILGNGEIISTDEAFEGCQDVNTEIYTKFLPEFTCLIIDDLINDIFIQNNLLSRDSFPQILKYYTPISDQLVNFLEEDRVCALIWMFYYVEILPKGKTIHSTETMNKYLDKLKILNGNLIYQTPWTNFLVQRVICSAGIFDGYLNPGSYLHLFLDQIICSQMEHRLEAKYFLLRFICYAKTVLGEWMTKKYLERLNPKVLIADGNCVFGDEDKANYLEAYDKISKKLAPKTVNIDYKEEGSKVQTLINLANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF40</accession>
    <name>A0A0N5BF40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF40"/>
    <dbReference type="WBParaSite" id="SPAL_0000460900.1">
        <property type="protein sequence ID" value="SPAL_0000460900.1"/>
        <property type="gene ID" value="SPAL_0000460900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894490" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000460900.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15441" checksum="9DCAA8F5EB04D338" modified="2015-12-09" version="1">MVITFTIKFLVLLLIHGVILPCPVKCYSAKFFNDNSDFYKKYFMKHYNLNYKLPLDYQYYHDIKNIDDFPVPELLVKNIDDHDKYGEGIGINEVIKEPLEPEAIKRSLLGNKRNNSLKLKLLNQGARGFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF70</accession>
    <name>A0A0N5BF70_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF70"/>
    <dbReference type="STRING" id="174720.A0A0N5BF70"/>
    <dbReference type="WBParaSite" id="SPAL_0000463800.3">
        <property type="protein sequence ID" value="SPAL_0000463800.3"/>
        <property type="gene ID" value="SPAL_0000463800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000463800.3"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113647" checksum="40CEB47AB2158317" modified="2015-12-09" version="1">MTGPCSKLFLSAVREARDDNKRRNHIAASTASLSQSLIITGENVNNFESNSSDNNNSNTQNNKSIKNNFKKNNNKTKPRYHGSMDSLNTDGGGNKTNNPCILPLPLLQMASSNQQNTTTNSPFPTAANFPRTPQILIDPNTGQQYIIPAPQPQIYYQPVYIPAQTAQPNQGQQLFFTPSQNGQIQTQPFILSAQGTSTSGYLYTPRNSNQGSNVSTPVIGQQNEAQQLFTCDGFSRLSNNTTKDNPETPLSSRSNQGNLLTTTFAQMKISQNNRRKGSVEQLSQMTSLDDSKNITRPTLNWNSPKREIKNEYGDDGPRTTPTSPSKFLSKRTPFHSNNYTGNDTKVKSNNDEIKEPTTPTVIQKPIRMDFDFAKIEENKEKKDQAKTPVCRVPPTAFTISFDDDEDGTNDGNVSKKNKPKNLQEARMKKLNSIRNENLSNGGQKINNKKKTNNDNDNSSTTSEDPKRYLLTKLLQGSSGKMSSKLIPNNLISSTGNKSIGSIGKGEDTLSDAGTYVITNDSNKEVSMSKVIDSDDDDSINRSESEYNCDFNEEEEDDYRSPSPINNFKKNNSKYCSNESSSGKSHTSEGTVKSGNMFSYDNENKHKYAMSSTTSSIKCQQQQPLTSNVKNDNQTGGKKIPSTSGTSIKQSSKSGSGRATNTPSVVVKQTVASMARQAMNHSNVENNKDNRSRGVLSSAGTPSTSNNFRRADGGRFSMRGSGTTTVNQKPPFKTGVASARGSSTASPRESSEFAAWLRRKDYNPMKAAAEAKKMKELKSRLIDIKKYKYKIDNNINLNKHLYHDNADSYVSTRSISFHHGAITSKDSNLISDKNNISPRFSISNSKLRNKAPSKDNDIMMTSMDSINENDDDDVGKSKEDIVPSPFTSTQSLHLSKAVDELTHKCQKSIQLIKLFSGQGLSESMENLIEEVISPDSINKDNNEAIVGEDLGHRLENLNTAFDAIQKCLEGFHKEMRHGSPMISRRNNVNSDVNSETTISSQYQDKRSNIGQSRHSLTSLGSSEDSEKITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFY9</accession>
    <name>A0A0N5BFY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000489700.1">
        <property type="protein sequence ID" value="SPAL_0000489700.1"/>
        <property type="gene ID" value="SPAL_0000489700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894531" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="79"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000489700.1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119746" checksum="861E9C75D158ADC9" modified="2015-12-09" version="1">MKIIFLLTLTVLFINYRVNCRLDWNSDIVPTNNDIEGAKSDALVRYFGDKAEESSIFLTYDNVSNLIGEYTDIDKKRFRNHNYEKMKKYIHYLNSTFPDITYLYTAGHSVEGRELWVLIVSKNPTQHELLKPEFKYVANMHGNEVLGRECLLYLADLLCINYGKNEYLTKLVDDVRIHLLFSMNPDGYEIATVGDRMSGEGRSNINGVDLNRNFPARYPEHKEPSGGTEPETETNHVMTWIKSFPFVLSANLHGGSLVANYPYDDSDSGKDGIYTPSLDDKLFVQLAYQYARAHKNMWKTGRRCGLGSDGDTFYHGITNGAAWYHLSGGMQDWQYVHTNTLEITIEMGCYKFPLDEMYEPLWNDNKFSLIAYIDLVRYGIKGIIKDADGNPLVGAKVDIVGDKKGKTITTTDKGEYWRLLAPGKYQLSFTHGYHQSKTLDIFIKPRELIHQDIVLEEPPCGFNDNAKEEVYFRGFSEYKTVLIGIDNIGKQIVTQLLSGLCNKSFPHVKTLLKNTKIIGLPQYVPEEHLPYIKAQSPTILIFLGMGETKSTIYIPMDEAPKAFNQKILDDALNITFNKYNDNSCKGILNDEHVSTMAADIGLEKSFILGIGFGCDITMAQNDDALGNIISTINSIVITAKKDAVEEYSVVPSVNPLDHFTPIDVIMSTSAGLNRIEESKYCDTTVTMIDTMRVLEIGQQKSGPRTLIMSIEARTEHMMYQMLSYLCEVSPTDHDYRVKRFMENSRLIVIPEMAGTQLNCHDYSTIIPFEPMLKIILDKYPDVDFVIFMASGGLKVRYINASNTEMSYQLSEAYIKKHELMKGAYWNICSKNKKMTLVNGELQWNNTKEDDWKKPDALLVQAGCCYEASGDGHLFEENRNSLFDVLESRLQGISGRVFEDGKFVGKKIEVNILQHGQLYKKVETNPKTEGYYHLWLPVGDYTLQTLDDRFPKQEIDFHISSATSVVINIDISKGGKPLNTGIIVVGIVIFVVGLGLYFIFKGYNGKKYFTLGNSNDGFERIPLRDNMDDDSDTEDDNNDKLFSFKVEHGIMESSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG74</accession>
    <name>A0A0N5BG74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG74"/>
    <dbReference type="STRING" id="174720.A0A0N5BG74"/>
    <dbReference type="WBParaSite" id="SPAL_0000498200.1">
        <property type="protein sequence ID" value="SPAL_0000498200.1"/>
        <property type="gene ID" value="SPAL_0000498200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF8">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000498200.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22596" checksum="04B6DF382E48A95F" modified="2015-12-09" version="1">MMEDRNSGDKKIRTVEKDSVKHPFSIDNILQVCSPMKSLEIFSTKDPQNQTDLPIKCKESPIGEEKRRRHRSTFTSTQIRILEYEFMNSRYISTEHRSRLANFLGISEQQIKIWFQNRRYKTRLMFLEKNDTSNRIPNLSVKNQEHFTVNNILTNNLLFTKQENLNNIQSLFHYNTCTNFKNTVSQRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGB3</accession>
    <name>A0A0N5BGB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BGB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000502100.1">
        <property type="protein sequence ID" value="SPAL_0000502100.1"/>
        <property type="gene ID" value="SPAL_0000502100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF1">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="534"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1223"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1322"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1431"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1535"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1747"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1853"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="893"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000502100.1"/>
        </source>
    </evidence>
    <sequence length="1908" mass="211513" checksum="CCDB13E8916CA0B9" modified="2015-12-09" version="1">MSHTSDDDRSSSKSVIYSVTRNALTQKEFDETFKNSTKEVKKFKGKAKNFMGKVFNKKCLSTECLMNWIPIVRWMREYKIKGLSNDVSAGIIVAIMNVSQSMAYAQLARLPPVVGLYSSFVPTLAYAILGTSKHISLGMVAILSLMVETAQQAYYTDYNLSYDNITSIVDGELDPNSLGLLTPIQVTVTITFFCGLTMLVMSIFQLHILTTYLSDELVGGFTTSAACYIYLAQVPKLFDIHTKSHGGFFKFFKIAIDFFSHITKTNFAALIISVACLIVLYVGKEYINPIIKKRISYPIPFELFVVIITILLSYFFEFNKKYNVKIVADIPTGFPDPTAPIFSAFSSLIVHSITIAIVIYALSFSCGKIFAKKHCYTVDAKQELRALAISEIIASFFSCHPTSGAFSRSTINSQMGCQSQVSSIISATTILLIILWAGPVLEPLPLCVLSSIIVIALQTMLKQFLEIFNIYKKSMVDLSIWIVTFLGVILWDVSPGLLIGIGYALLTVIVRIQSSKTVMLSKIGNTDIYKDTRRYKASYAIPNVFIYRFDAPLIFINVENFKTKINYFLSTSFLESDMENNNENQKKSIIFDCTGITLIDLMGVKCIEELYYDLKSLDVNLLLAGCKFPLRKMFEKCGTYTKISKDYFFPSIHDAVLYAEYFTRNKKSTTLILDNKNVQNVPRGQVQYRTINCNRNCNNNNNQNKFKVIQKPISNIRVLPNNVKILPNIKPITRPPNIELVTPVSTQSPYIHNSTRITAATQAPYSPITIQEILTPPPSSPTLNITSPVVTTISTTSEVETSTAPVVTSTTTMSSTTTTTESTTTTFTTTTTPTTTTFTTNTPITTTYTTTTSTTTTSTTTTQSTTVTEAETPSTSVEFVTPISTTQKIIPTTTTATQETSKTTESSSTLTEEELKATTTFYRHPNRKSTTKKNYLSTTETPTIPTVEEETTEITTEAPIINPIVEETSETENKKEIPTTTEVPLTESTTTKKPLTDSTTTKELLTEPTTTKEPQTESTTTEEPRTESTRTEEPLTESTTPFIQTKINPCPNGTPYGWGINSTFSTCSYLLPDNGGCPDNYYCHTGANFLTTTCCPLPDGVDNICNLPRTSGEGENFLSRWYYDNLSHSCKRFIFKGLHGNGNNFMNQIDCEATCLTSFNTPKPSEIINPCSYGEPATLNNDSSSQVQCNGPSDLVCPVDYYCHVSGSQLTSVCCPRLKEEKCDQPLLTGQGNSILDRYYFNKEKRECEKFIFAGLKGNENNFLSLSECERICKPWISPCPMAENTKPPRKSCNLCNNDEWCHVGDSPSNTVCCPNPVEDVCSQPLVIGNGSGNVTRWYADPEDQSCGRRCLSFTYSGSGGTQNNFLTKEECESSCKRECPNPCSSGELLLTGNGDPRQCNQSSPCPSGYWCHVGEIQDTTVCCSSVRNICELPLAVGVGEGQLDRYYYNSQTKSCIPFKYKGMLGNQNMFLTEDDCKLMCPVYENPCAIDSPLLTSSKKPKICSPSSRCPSTHFCHIGPRGTDNYCCRKNGNPCEQELEEGLGNHSLSRYYYDLSTRTCKPFIYLGGKGNANNFLNKNDCEIVCPVVLNPCSIGNPLTDPNGDSVVCGGHDTCPSDYYCHIGSSPDTTNCCPIIEGNICKMVLQTGEGSDKLERWYYNSTSQKCIKFIYSGLQGNPNNFLTLDECKNTCQDSNPCLNGSPLKSSSNNLLTCSSYNGIDTCPSSHYCHLGATVTETVCCPRMTQDPCEQPLNDGEGNRMINRWYFDTGLNKCLPFIYSGIKGNENNFPTKTQCNAACPEYKYYCPHGLPILSSDNDNQPLTCSIDKACPDGSLCHMNIEFNTSICCEDPSYFCSEERDHGPCDGNEIRYGYDSETDTCIEYKYGGCGGTLNNFISLQRCTEVCCKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGI3</accession>
    <name>A0A0N5BGI3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmodium yoelii subtelomeric region (PYST-C1)</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGI3"/>
    <dbReference type="WBParaSite" id="SPAL_0000508900.1">
        <property type="protein sequence ID" value="SPAL_0000508900.1"/>
        <property type="gene ID" value="SPAL_0000508900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894565" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000508900.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10789" checksum="9AC967678C5AE5B3" modified="2015-12-09" version="1">MNFKFNLSIFVAILVTFAFNCLADSDAFKYVADSELQMRNKRHDLDSNNLSVHNLEKRNCKDKISNRKNKVDFKSKDKGEGFYLNSTSLGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGN9</accession>
    <name>A0A0N5BGN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGN9"/>
    <dbReference type="STRING" id="174720.A0A0N5BGN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000513900.1">
        <property type="protein sequence ID" value="SPAL_0000513900.1"/>
        <property type="gene ID" value="SPAL_0000513900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000513900.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="10002" checksum="46A3F8C5924AA17D" modified="2015-12-09" version="1">KLRELRYETLPHLAYSPNLSPTDYHFFKHLNNFLTEKFFRNDEAAKTAFEAFIESRSPDFFVDGINKLVSRWQQCVDCNGSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHJ3</accession>
    <name>A0A0N5BHJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000543200.1">
        <property type="protein sequence ID" value="SPAL_0000543200.1"/>
        <property type="gene ID" value="SPAL_0000543200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000543200.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17305" checksum="4BCC45378F3183AB" modified="2015-12-09" version="1">MFFFLLFYEYTIFGVIFFIKEHRWDLNTEKFLRHPLASVFCTRDSMGRLHRFQVDVGYLRQIDFWTGNSRSAITRNKCRFIGPLLNIITSTCSNILETLRVLLWTPKARGSARPSFVGIRMETNDLIHTPLSIGSSPVFAALLWTLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHL9</accession>
    <name>A0A0N5BHL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHL9"/>
    <dbReference type="STRING" id="174720.A0A0N5BHL9"/>
    <dbReference type="WBParaSite" id="SPAL_0000545700.1">
        <property type="protein sequence ID" value="SPAL_0000545700.1"/>
        <property type="gene ID" value="SPAL_0000545700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="2"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000545700.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55286" checksum="2B3A7B4EA45DE8FD" modified="2015-12-09" version="1">FNMWVPNGGENMSVIVFFHGGSWTVRTASVDKFNGSVLALKTKSIVIAANFRLGFFGFAYLSNSSRISGNMGLLDQQALLKFINKNIYKFNGDNTSVTIFGTSSGASSVAAHLFSEGSKPYFKRGIMSSGTITHFMSTVSTTIADNNTRSVAKKVNCTKDENSSITTDDEIAECLKRVNVTLLLKAARNVSAPGQFPTPFPFMPINKDTVFFNGSIKDMYKNKTFNTDVDLMMGRTGDEATFFMATGFTNNSRYGCYFYPQKNATDPANACSMNETNFINLVSFGSKILNFNDTENQTLIEIYNNSATTYTNRSIRILSDFVFDCELSSFANKYANVTSKNVFLYEYARRSPINIWPNWTGAMHGDDLIDIFGIPFRHPEKYKINGESNGENGNSKDSVREEQTLSEHVMWAIGNFSKYGNPKNHWENATSSSLRSFIFNGTLSFVNITHQNFTPPTCIEFAKLMRNVTTRIKTEMEEMKKKKEEEMKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHX2</accession>
    <name>A0A0N5BHX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase TOR</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHX2"/>
    <dbReference type="STRING" id="174720.A0A0N5BHX2"/>
    <dbReference type="WBParaSite" id="SPAL_0000555700.1">
        <property type="protein sequence ID" value="SPAL_0000555700.1"/>
        <property type="gene ID" value="SPAL_0000555700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000555700.1"/>
        </source>
    </evidence>
    <sequence length="822" mass="94313" checksum="440F6FB1B18EB7BC" modified="2015-12-09" version="1">MYQSFLCCWSTFKPRHYKLVDSVYPKNELESRPNANIDKLVFYSCSHGEKLSRIGEYLFLKLSRDLYRQKLARVRVGTECFIRLLKSSHHHNSQSSFIDSYLKMVEKLLETNDPQMEDLAIECYIVFAQIDEVQPNYSRRYDSFIPKFASMCYTNRGNRIKQQRCNGLKGLLALIWRATSGDYHSDFWNHEHMDKVIPSILFNIKEDDDETASDNVRFSVNTFSSQENTEPYIIAAECLREIMGKSSYGSFQCVLEPLLTFCDDQKKWLPPATFATHVFRVVVYSIQGTSSIIVIEQLLKHLDKFKTKNVQERIGIATVLSNIVLIAGQSIGPLLLATYNNMLKNLKMSVTFQKSGRCKDVENELVFQETFTHAIGNFASILPDYQKVEIMTFTTNEICKIPDNEEKASVDSYYHHVLASTFLKIATKYKTVYLSTLFTDNFMTTLLRLGLHPNIDIRLIVQKLFHTLLDRKDNLKNLEKLPFINEIEDLNLTIEKCSKADQMFSRRFITSVSDVFYDIMFLVPNEDEKVISTHIEAILCTMALFCVEVGCDETLIEMIHLCASYQTIAMNINNDFSDLKRYHIHMLCGKFFNFISLILQIPSFLQHVRDILNLRKINFSVTSIEDGSFEEIFDRNLIVEALKASGLDVGRFNVPLGSGADKMGRDPLLKIGTPHRKGSNFSAVDIKNQLIPNNTVSFDISIDWSPECSEAGTRRNTLVEDKIIDSINSSTIVSLRQIMHSPNTSSDEIRKDKDVSTALLMPYRKGHLDDVAKALLKDNSSNLSTKIRNIIEKSNVQEEENNFLRNKPKNVFDIAIPESFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI62</accession>
    <name>A0A0N5BI62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI62"/>
    <dbReference type="WBParaSite" id="SPAL_0000564600.1">
        <property type="protein sequence ID" value="SPAL_0000564600.1"/>
        <property type="gene ID" value="SPAL_0000564600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894299" evidence="1">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="3">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="2">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000564600.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34483" checksum="618909115F7727E3" modified="2015-12-09" version="1">MYFIVTVLALVELSIYSQGTTHEHFFPDIPKNLETDTFPYDIKIYSRSDVVAVKCPIRGYHHNSEVSYLYQNWDYILYEPQPKATIGWKMTQKTDYRETETLICGDVTIYKTINGTSEFFGETRWKYRINWKDNPDPYKLAIEGKEYAYTESIPEKCGLSVEDLIILRARRGIWLDNLDISTKNKVLSNLLFCFFKKPNETDEINYMYIEPCLVLDAFNFCPQITILDLEHTTVPYKGYEILAFKLNEDKETTFDIRLNLQIGGRSLGYYNTDNVAITRMLNFKNTIDYAPMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIY0</accession>
    <name>A0A0N5BIY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIY0"/>
    <dbReference type="STRING" id="174720.A0A0N5BIY0"/>
    <dbReference type="WBParaSite" id="SPAL_0000590900.1">
        <property type="protein sequence ID" value="SPAL_0000590900.1"/>
        <property type="gene ID" value="SPAL_0000590900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF150">
        <property type="entry name" value="PHD FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="329"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="388"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000590900.1"/>
        </source>
    </evidence>
    <sequence length="754" mass="86453" checksum="F835DF34D5E26832" modified="2015-12-09" version="1">MSNTRNDNLKRIEESSNGDVNNCSLLDINIKNFRWNTCAVYRLEKFSELLSMIGHQHITYSSGGCYRYYKCKDNQCPARLRLHSKKDNGEIAVFVRQVHVCGYDWDEIVKGDGVIRLGDLEKGNDKVKVGKSITSTDRKRRRKSDNTTGKRKKNNANDKLALSFACDDYVHDIKIKDSPPSNRVVRKAKKKEVKVKLKSEKSDSSPESGDEKYDNNKNGINNSTTSSRSSSSSQSSRQNTPINLSQKNLRPKRKSAMKAMQTEILSNGKEKNVDDDFEDSDDDDYTEGSVKSSDEEDNDEPEVVVVDSNNQPTTSRRFQSYTLTHIDLKKFCGFCLKDEESDDSLLQCTRCKIRVHEHCYYVKNTFQPDTQRILSPWFCNECLSDSGTLNCVGCHEKHGPMKQTENGWIHGFCALYNNDIYEALVDNLEGPFYLTKTALSKKKFRCIFCDNPVLSCVGFTIQCEADKCSVRYHPMCGLKYGATFNIFPDDGYKNLSITHCPLHSTSETEKSKSYSIYQVFKKEYNGLSNGVEKKHTIQESHKKSFNAQKKLMDNAYKEWLSKTREDIINCSLTPIPIDLLSQLIDKEKKNQPNFDLSKSFDNHFPKTKSFTKEISILDKRCNELQSNSLQNITNECLSLIKRAKLISPKLNNNKGKLNKLIPSDGIGIMTHMYDQLFPICDDIILKVVDMVSGNLEEDEVIDRNIVLIRSFVRFKKDYLKYGKNNCPDEDTIKMCMVNLYRCLHNYANYFESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJI3</accession>
    <name>A0A0N5BJI3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJI3"/>
    <dbReference type="STRING" id="174720.A0A0N5BJI3"/>
    <dbReference type="WBParaSite" id="SPAL_0000610900.1">
        <property type="protein sequence ID" value="SPAL_0000610900.1"/>
        <property type="gene ID" value="SPAL_0000610900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="8">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="6">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000610900.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39749" checksum="255DF0DC31DBCD16" modified="2015-12-09" version="1">MLEKASLIIIDEAPMLSKYVIDYLDQQLKKVCKNDLPFGGKVIICGGDFRQTLPILPNSTRHQNVLFSIKYSPLWNVHFETVKLTRNMRVKEDEIDFAKWILDIGDDAVKKNEDGEVDIPLNIQSTGNLVNDIFGAKNESILEKSNYAILAPTNVIVESINNEVLDTLPGDVEKIFSADSIRKDSDTDENYYNMPIENLNQLTPSGLPPHVLNLKVNAVIIVLRNLNIKEGLCNGTRLRIIKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEYPFTLARKQFSVRLAFAMTINKSQGQTLSKVGVDLTTPFFSHGQLYVAFSRVKSPDCLFVKTESDKAKNIVYTEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJZ4</accession>
    <name>A0A0N5BJZ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJZ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000626000.1">
        <property type="protein sequence ID" value="SPAL_0000626000.1"/>
        <property type="gene ID" value="SPAL_0000626000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000626000.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17293" checksum="44E19DC07B085BBF" modified="2015-12-09" version="1">MVNGRSHSETLIRFLKNLGSPSTHNKDIRDFSNFALTSISSKSFQLTNPLEGNLPLLSDFAIENSRTLSTSFKHYSESTHENSIYLEHKSGPRSEPKENITLNTLSKITEYHDIENNEQLNKLIEVNLNHMHINFFNSTDKIIMCVWIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLP4</accession>
    <name>A0A0N5BLP4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynactin subunit 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLP4"/>
    <dbReference type="WBParaSite" id="SPAL_0000683900.1">
        <property type="protein sequence ID" value="SPAL_0000683900.1"/>
        <property type="gene ID" value="SPAL_0000683900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000683900.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27301" checksum="2D2705262162D602" modified="2015-12-09" version="1">MAVTIDFQDIFLIVFHREMRSQLQDVVVVGEIEYMIKREFLIQSAYCGSELMNRQVIAQGNYMEPGKCVVKTDVLKEQRVIHYGGQEVVSLKSALSLHRIVAQERIYTQLNDIRNTDTFDESLSGNVIVYPSFDEPKDVIRENLLTNISVQSDQNDNESALSITICKSPPLLSSDANYQLPTTSPQDSSDLSEEIYPPVNGVEEKNNSFFSNYQDSILASLIKESDNEKEDGSLYGEPSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMP7</accession>
    <name>A0A0N5BMP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000718575.1">
        <property type="protein sequence ID" value="SPAL_0000718575.1"/>
        <property type="gene ID" value="SPAL_0000718575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000718575.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14336" checksum="C1BD4E06C415EC22" modified="2015-12-09" version="1">MVIARLPSELSGFGAPRQQLPSTSCAVAAITSVPGMLRQQLPGTGHTAAAITTVLAILRQQLPGTGHTVQLPQYRPYCGMRCHVRASSKFDAPRQQLPGTGHTAAAITQYWPYCGMRCHVRASLLPLNNTRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN14</accession>
    <name>A0A0N5BN14_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA topoisomerase I</fullName>
            <ecNumber evidence="9">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN14"/>
    <dbReference type="STRING" id="174720.A0A0N5BN14"/>
    <dbReference type="WBParaSite" id="SPAL_0000729500.1">
        <property type="protein sequence ID" value="SPAL_0000729500.1"/>
        <property type="gene ID" value="SPAL_0000729500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="295"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="578"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000729500.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="80788" checksum="0F081E7A9863264B" modified="2015-12-09" version="1">MTATIASSPMSSGCQNISIRTYSDDCHMKDVNELKKEDLSEDDIPWSQRVVKGERKGENKKPKEQKKKRKKDSDEEDEYIPEKKNKKEKKVKEVKEEVMTPVKEKKSKKKSKTNEVKEEKESPKKRKKGKQEEEEEVWKWWEEEKKPEGVKWNTLHHNGPMFAPPYERLPEDVVFRYNGKVMKLSDEAEEVATFYARMIGHEYTEKEAFNTNFMNDWQSVMTEKEKGIITNLEKCDFSSMTRHFQELTEARKAMSKEEKQVLKDQKEVEVKKYGYAYIDGHKQKIGNFRIEPPGLFRGRGGHPKMGKLKRRVLPEDVIINCSKDKIPEPPAGHRWKEVRHDNTVAWLVCWTENVLGNNKYIMLNPSSKLKGEKDFEKFETARRLKTKIDEIRKAYRADWKSKEMRIRQRAVALYFIDKLALRAGNEKDVDEAADTVGCCSLRCEHIKLHDELDGKQYVVEFDFLGKDSIRYFNQVPVEKTVYKNLKIFMENKDPNDDLFDRLDTTTLNSHLQTLMPGLTVKVFRTYNASFTLQDQLMKLSNKDDTIHDKLLSYNRANRQVAILCNHQRAVPKTHEKSMENLATKIKEKKSELKKAKTALSEASGKEKEKLEKKVARVKEQLRKLKIQRTDKDENKQIALSTSKLNYLDPRITVAWCKKMDVPLEKVFSKTHREKFQWAIDMADEDYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN21</accession>
    <name>A0A0N5BN21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN21"/>
    <dbReference type="WBParaSite" id="SPAL_0000730100.1">
        <property type="protein sequence ID" value="SPAL_0000730100.1"/>
        <property type="gene ID" value="SPAL_0000730100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894561" evidence="1">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000730100.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47499" checksum="B98CDE59ED79D3E3" modified="2015-12-09" version="1">MISKNTSIFLFFLQIILTVNGKNLPFNEKINSGKIQFNTPCSNYYGLFIIDNTNSGNKMLSMQLTIVDYFFDFASSSNYSASATVTSQSTTSVTNNFNVVSPNDYASLNKQFNQVIQQIAGGSNISYFNLIVQALQLNLVDPSVYTYNPLLIFFVDSPIVDLNSTTQILENLNIKNNNKVKFLAIAMDPQYLEEAGKLVGGTTNAYAFNSSDQNNYNNINNWILQQGCSSSLTPTTTTTVKPPCDSYVNIVIDASSDGLTPQQYNLQIDLIENYILPMWSNFSKISTLIMYNETEILFREYNNYETLDYIRSFINNSGQSKSNTTFLHGAMYILDENQSYLQHKTQMSTFVFLASVSEFEIAQAAQDANNLAYFGKLNIITMGSNIQNTALAPLQFSNLINWDYSSGEIRLIQEFVSGNLKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPN6</accession>
    <name>A0A0N5BPN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LNR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPN6"/>
    <dbReference type="STRING" id="174720.A0A0N5BPN6"/>
    <dbReference type="WBParaSite" id="SPAL_0000786100.1">
        <property type="protein sequence ID" value="SPAL_0000786100.1"/>
        <property type="gene ID" value="SPAL_0000786100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876:SF1">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894828" evidence="4">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000786100.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17353" checksum="16B170C1D39D9FCA" modified="2015-12-09" version="1">MTSIIILGILFLFPIVKAQIYDVQYPACSSPFQWSCDSGECIAQYDLCDGIPQCGDGSDEKYCNGRVRSTTPHLPAKTNTGNESKNNTTLSIWKLPPYSFNSHVSIVGIISIAIVVIFYLCVCRQRRRPPHHNFRKSDLITEDEDELLINSMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ00</accession>
    <name>A0A0N5BQ00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ00"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ00"/>
    <dbReference type="WBParaSite" id="SPAL_0000797500.1">
        <property type="protein sequence ID" value="SPAL_0000797500.1"/>
        <property type="gene ID" value="SPAL_0000797500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000141">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000797500.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15696" checksum="8736E1D3BE6BEC5A" modified="2015-12-09" version="1">KNWHVEHFVCSVCEKPFLGHKHYERKGLAYCEEHFTKLYGSTCFRCGKSCGGETFTALEKTWCLKCFGCHLCDKKMDHKSKFYEFDMKPTCKKCYDKFPTELKKRISDRLKERNQIAVERQRRSMSPTFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ21</accession>
    <name>A0A0N5BQ21_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ21"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ21"/>
    <dbReference type="WBParaSite" id="SPAL_0000799500.1">
        <property type="protein sequence ID" value="SPAL_0000799500.1"/>
        <property type="gene ID" value="SPAL_0000799500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000799500.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49810" checksum="455D423EEBB40C5C" modified="2015-12-09" version="1">MEVTQQSIDLNTQFSGHDDVSFSLSKDILIPKGFQLKSSNGLITFEELIGKGGFGKVYKIKVFEKQLALKTIESEQQTEISILMTYCLPHEISLFYSGRNVKEPPIIKFLGSGYFFYLEHTFSYYVLPIYTEDFRQFNKRKIESCESIIESTFTVVERIFLALEYLNEKNLVHNDIKEENIFLKMNNKPCSAVLGDFGSAIFGPDLEKINIRGTPNFMSNDSHRGKSTYRGDLLTTIFVIYNIFMTLPWSKVTNLENILKQKEMFLLDITLILSPLTNHKFYNIFQILLTEYQNLQILEKPDYCTILKKIKSVFKSKDDQYLATIMETLNLNEKEEKLKCNIRFENVGKDFMKLLSYTTRKDVDMFLTLVTLKHTNGFAYTYSFASGDSKCGCKKLAHYYKEHECLFLGMVSFSRYIFKKNKIMVGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRF2</accession>
    <name>A0A0N5BRF2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caenorhabditis elegans ly-6-related family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRF2"/>
    <dbReference type="WBParaSite" id="SPAL_0000845100.1">
        <property type="protein sequence ID" value="SPAL_0000845100.1"/>
        <property type="gene ID" value="SPAL_0000845100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF8">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000845100.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17944" checksum="A2A2E8F5A5CC6E5F" modified="2015-12-09" version="1">MSAQYEDAFRNNGVLSEHFYEPRNFTDECNDPINDRYMGTVSCRNICLTITQDIISLGIRTGKKLTIRGCSTKLTKLGFRNRTINLLDRFDSCRYVKASDLFLYPVDDSVTVYVCSCLGDRCNSSKRSNCHTSIYSTAFLITVILPFILCSKLLQSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRM7</accession>
    <name>A0A0N5BRM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRM7"/>
    <dbReference type="STRING" id="174720.A0A0N5BRM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000852300.1">
        <property type="protein sequence ID" value="SPAL_0000852300.1"/>
        <property type="gene ID" value="SPAL_0000852300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="158"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000852300.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45276" checksum="5C3B763E7AB210C6" modified="2015-12-09" version="1">MSLSIQEKSKILEEVEALKGLCVALAKKLEISVSTLNTIVRNKDSIIKNVNESGHFCKKRKYASYSNVLLREKALNVADKLSIENFSRLMVGLIDSKSVTILFSKVVYGEGNAVLEESVREWQEGKLKDPHETGLFFCVLPNKTFTFKGENCHGGKNSKLRLTVMLGKSKKPRCFKNVKTLPPKYEANKKALMTSDFLGKQMYALDAKMGAQNRRILLFVDQCSAHLKKINLKNIRIKFLPANYTSRLQPLDLGIIHAFKISYRKNVVQRLFDFIESGKDTMTYKISILNALHYIAKAWKDVSQSTISNSFRKAGFFQTHEEEVIEEDSDLISAWEKLKIDYEVKDFLHFDVELATVQTVSVESLINSVQEERDSDSDFDDDSSVSLVQKWFLQKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS72</accession>
    <name>A0A0N5BS72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS72"/>
    <dbReference type="WBParaSite" id="SPAL_0000871700.1">
        <property type="protein sequence ID" value="SPAL_0000871700.1"/>
        <property type="gene ID" value="SPAL_0000871700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="176"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000871700.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45498" checksum="FD38DFCCCB792CFA" modified="2015-12-09" version="1">MLTNSQNSDTTQSFVKFKMNVFILILYTYGLFSISQGGIVNELNKGDPKVSTIIESGIISLNITIEATDLDEYLNPNVDPCDNFYLFSCENNETFFEKIDQMKFERNFDSMNSFNVTSMENCYNNIGIDYNDRFGKVLVLIMHYKAVSDVYGMDLKSCEGKIFQPIKYLNKNILRNVYYDSEKNTVTVNSDYFNEPMFSRKFPMSPNYGGIGSTIAQKMLEAFDNVDYKRILEGDNRNKLSFTQMLMENYKVKSDCFVKQYGLQKESITNKNINDLLTLNENFANNGGIKIAHRAYMKHLESIGSENIFLNGYFKFTDEQLFFISAGRQYCEYTTKGYLEKLIDMRKYPAGEIRTNMALSNYKPFSNAFKCKLNSKMNPRDKCELWKNQKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTH3</accession>
    <name>A0A0N5BTH3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative H/ACA ribonucleoprotein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTH3"/>
    <dbReference type="STRING" id="174720.A0A0N5BTH3"/>
    <dbReference type="WBParaSite" id="SPAL_0000915600.2">
        <property type="protein sequence ID" value="SPAL_0000915600.2"/>
        <property type="gene ID" value="SPAL_0000915600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="9">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000915600.2"/>
        </source>
    </evidence>
    <sequence length="438" mass="48724" checksum="51902CCB95A83382" modified="2015-12-09" version="1">MGKKSKEGKKSKEEVKDEYILPSSTEPGKMNSEEWPLLLKNFDKMNVRTNHYTPLPDGCSPLQRDLKNYVSSGYFNLDKPANPSSHEVVSWIKRILRCEKTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYVAIFKLHNSVDGEKPIRNALEKLTGALFQRPPLISAVKRQLRVRTIYKNTLIEYDNEQNMGIFRVSCEAGTYVRTLCVHLGLLLGTGGNMLELRRSRSGVTSEHDGLVTMHDILDAQYLYDHQKDDTYLRTIIRPLEALLIGHKRIVVKDSAVNAICYGAKILLTGVLRYDDGIEIGKEIVIVTTKGEAVCIAIAMMTTATMCTVDHGIVAKTKRVIMERDTYGRKWGLGPVASRKAQLIKEGKLDKYGKPNASTPAGYISAFVDYSATTNSDNRKREATDDNDTVPEKTSKKSESSSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUM5</accession>
    <name>A0A0N5BUM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUM5"/>
    <dbReference type="WBParaSite" id="SPAL_0000954600.1">
        <property type="protein sequence ID" value="SPAL_0000954600.1"/>
        <property type="gene ID" value="SPAL_0000954600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000954600.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="63295" checksum="6A3123943909591B" modified="2015-12-09" version="1">MDFKTNFSFVELMEINLIRKKIIKELSSWSDFENLSKTCKWIYYLVNKENISRKMVWYNDMPHIKIDGVRDSYESTVRNQNLSEIAIKKDDRYSKTMDDGKKYNHEIIINGSSINLSIENGVGKLTKNDHEIFIKQLTNEIENICHLRKHSTTLRFMEYYFANDYMLLHLLSNLNNHTITSIHIPLHSMMFGAQRYKGLNEDIFEGLSKLNELVLFTSPAINEFTPYVNNRTIVDSILKSFSKKKNPVLVFKDLGCGYQLISSYIHMILGIAVKYEIKIKWNITSTFQFLNQKNNDRCSIGSCSHFPLEKFISTFSCSAREPETFIHTMKNMRCLENLETLNLRIFFSNLKEKIERMGIDIKDFSLQHCKSIKNLVLDFKEHLTINYNTDIETIHDDLKYLASLMPTTVQKLEINNCQQLTNEVTEVITQYMPNIQIIIFNNVTYNDLDSLNSFKNLQVYISSNIFPPQLPNTVEFLAVGNGCNLFSPNNDSPSNTEEQLRKYSKMFSKNLYTNRKDNIFFNDLITWDKYRNLLMDNFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWD2</accession>
    <name>A0A0N5BWD2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWD2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWD2"/>
    <dbReference type="WBParaSite" id="SPAL_0001013000.1">
        <property type="protein sequence ID" value="SPAL_0001013000.1"/>
        <property type="gene ID" value="SPAL_0001013000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="6">
        <location>
            <begin position="300"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="555"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001013000.1"/>
        </source>
    </evidence>
    <sequence length="1125" mass="131366" checksum="01BD6E11A0B2C6BB" modified="2015-12-09" version="1">MGNKDSYLIRSTDSKNDSDIPIKYEEAVEILTDVEFHRLEAIWSHRKQMNEFDFCRELFKNTKIPRNFQSLIYHKFCFDEDVITFESLVISIVILTKGDLAMKKKFLPEVNERFFNIFSNDSTMMDREITLNHNLYEVLSGVTHFTEDEIGQLNNFFYDICTIQKSKINFDKFKMICNGSLTPSQVKLLFKAYDSNEDNHIDFKEFLCALSASCRGPPVERIKFVLQMWDRDKDNNFSEETIYNIYNELDIEEKDRTLKIENSKVSLYDVVCWANGVKKVEEFLELLKQNSYVCFGLPLQTKEEEFMTLEGYRNSVKRTKNTEFYVISHKWWNKMIVGISKNNHEIEPIVGGECLVETNFPYDWMYSYEGRQMIGPILKQNIVENVDYVLVDKALFLFLRKKYGIYDNEIRRYCDCNGIVDLYPPLLLMHCHRGYEKKPWFWSLYPKTLPIKVLKNDAQEGFEIDDSNAIRLWLMPEMILLDNEDITLEKFIDDRKYLKILLEIRNRDMSWPEEMIEFFNTTNDSSISNKDGYTSSQSLANKNLLSIEKKTLGIVGLANLGNSCYMNSVLQCLIRTDIITDYIIKRLDEDVEDNSLVTAFGRFLCEVFAKENHKFTPGELKNMITNKCPMFADQNQQDANEFLSCFLNTISEELATSNNEKGILPETTYLSNTPADLEWKKQLKREFSIITLQICGQLKSSLTCQSCFNVSETFEPFTFLQLPIPDNDLLLLTIIVIPQNGKVPIRMSWSLPGHMKLPYIKSLIKNKTGIVETSIFFTILDSNFKLKQNIFEKLNNENVEVKSLCSLKECNIIAFEIVPESTDSCPVFALNRNDHFNDLYIIKAIDGITSYFFGMPLVFQYRPSITRVSDFYRDVYNKLSQYYLKDGNKNSTHNRAVDASENLKGRYPFEIVAVDNSFEWCAFCDWTKFCRGCNLEELGEFLSINVRNIAIHWKPSSLYLNYQSVMDLMCIDDDSVKREKEEYKKPVSLTTCLNDFVKPEILDDNLMCSFCDKKTKMEKKFQIQREPNILIVNLKRFVYIPSSGWVKSRKAIEVPFNNFTILSNGYNYECYAIVNHYGAIGGGHYTAYTKVSNKWYLFDDSSYNAVNIEDVDVKNAYMIFYKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWI3</accession>
    <name>A0A0N5BWI3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Olfactomedin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWI3"/>
    <dbReference type="STRING" id="174720.A0A0N5BWI3"/>
    <dbReference type="WBParaSite" id="SPAL_0001017800.1">
        <property type="protein sequence ID" value="SPAL_0001017800.1"/>
        <property type="gene ID" value="SPAL_0001017800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF85">
        <property type="entry name" value="GLIOMEDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="7">
        <location>
            <begin position="288"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="289"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001017800.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="66366" checksum="7E999B650934C2D4" modified="2015-12-09" version="1">MNLLIFDSGQKDDVKHCNGFDENVWKKYLKRMEYFQLLLFLVSIILFIHSYYELNNLENRIFLTAMKIHQLKNVKFQEKWNKRTKRENVDSINSIFPIDSDNSKLNLTRSEMWLQSLSKIRMNELMDKCLDLHEYCVEENGSERGPPGPPGLPGEPGPQGNPGPPGKEGLFGLPGPPGPSGPPGIRGKNAICPKCTVATELEMSGPKEECPKIEEMKCPHYNIFGNKFKDQEMPYVIEKALPIIVERMIENMTEVESCMRVCLTNVTDDWFAPPEVTETPYIKGATAHCYLEGVGRPVFHAHSNTFYGSWMRDAYPKSGKDSDKRWLAPHFQGDILYEYSSESDLRRQNVEEDHILPYIYSGTNPIFFNGSFYYQRIGYPSIIKYDLTTKRHKELFMGDYVSFRKKDYLFNLHNNYFDLAVDENALWVMFHYQDEPFLSVSKVDISNLTIYQTWNLTMVNHTDVGNGFVVCGVLYLIKNTTDIKSEIFISYDFYRDKYKTPNIKWVNLYQNANMISYNPFDKRIYIYDHGYLLTVPARIHWRAKRDINENGMDELSDNTDDIKENFYVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXN3</accession>
    <name>A0A0N5BXN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXN3"/>
    <dbReference type="STRING" id="174720.A0A0N5BXN3"/>
    <dbReference type="WBParaSite" id="SPAL_0001055700.1">
        <property type="protein sequence ID" value="SPAL_0001055700.1"/>
        <property type="gene ID" value="SPAL_0001055700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001055700.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36868" checksum="846305DB2BF35438" modified="2015-12-09" version="1">MNICKEIESTNKDLSTNNSLLSTHLNLRHRLRLAPLPTYKVWLYSTNILLILLQTIYLYFLCRLFQQKNIKNFPIYWDEKSLLGNYIIVGIQYFSSFCGILGVYIYSRHLLRFFWFVITSLLSLDIFFAIIIAIKFATLHATFEDHLSNSIKDKFKNNETIEICFDWKEFQEQNFCCLDKPIIDICLNMSFKNNFNETFGNIYSNCNKENTKKELCHYTLLRWIHREVDFLVIIYYFMIYPVKFIIVIALRDDISELFSEIIFTKNRHLYTHWVLDEDITSVDLSNSSFDHSTEENGIIYTGGANLKDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY78</accession>
    <name>A0A0N5BY78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY78"/>
    <dbReference type="STRING" id="174720.A0A0N5BY78"/>
    <dbReference type="WBParaSite" id="SPAL_0001074000.1">
        <property type="protein sequence ID" value="SPAL_0001074000.1"/>
        <property type="gene ID" value="SPAL_0001074000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895108" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001074000.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26612" checksum="558B17AC46953342" modified="2015-12-09" version="1">MSYLRNCIYILFFIIGNVILEIQTTSDFSLQCKKGYHITTIRRVASPYHKGPGSFQVECQLLDTEEDQVYCEKLTTAPQCNGQLEGCSGNQFLTGFHGYSLTNDSNVILLDPICCSSENVKIDSLSCSSERINSVGQSFSHKLETSDFSYRGLQCWHQYKSSDNTLLDMVLKLEICSITSKTFNSKRDWKLESCPPCKCSCGIQYCPGGRVPVKIIHKHFLPHECSCNCQCAYKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYW1</accession>
    <name>A0A0N5BYW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYW1"/>
    <dbReference type="WBParaSite" id="SPAL_0001096000.1">
        <property type="protein sequence ID" value="SPAL_0001096000.1"/>
        <property type="gene ID" value="SPAL_0001096000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001096000.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40532" checksum="4920E2543F6E35EF" modified="2015-12-09" version="1">MISDNNNSNTSITSLPSEIVRMVLQKVDWKTIHNIRLVSKFFNDFVSSNIDNLPKPMMTSLSISSTHNPDGKMYIEFLYLHEKEYIKVEDVYIPSENNEPRLPEMENLLIKMDLTNVMHFEIVVTGETIIFDVLDRYLKFGTTVESLQINIQKCPSFKGFSRFIRKIRYVTYLWLNKLCFLSQLIPLDFTLPMIDKLNNLCLVECECTKFFNPKMITNLYRNNKNLKRTLIFSNCKNMEYELIKVIKGKQEFCSGKKGCHSNSYLYLPLRNNSIHYAEIINNFPLNAYDISFPPEMDNTIIGVKECSKCAASYGIALSYRKSTYLNDTRCDSIFDRTLFIDDNFYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ66</accession>
    <name>A0A0N5BZ66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ66"/>
    <dbReference type="WBParaSite" id="SPAL_0001106100.1">
        <property type="protein sequence ID" value="SPAL_0001106100.1"/>
        <property type="gene ID" value="SPAL_0001106100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001106100.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30726" checksum="08CA83FE49390D36" modified="2015-12-09" version="1">MNKTIEYEIKTGFSERTIEVAHDLLAKETCLNFTRIYGQSTSATVIRKKDKCSASAEIHDKKIHYYINVNWSCSERDKLQRLIYWSTEMRYQITKCLAKHGRTEFLADRMIELLTTYHCIFENPRETDINISNNLLEFSGEKSPKKKDIVPSNLVQKDYSVEISFHDVRFLNEKICKDSCKSKPSKKCKNNSYPNPRRCTSTCLCPFFYSGTSCEKLVMPKDPWFCKSNPLLTATSKKRTLVLDLFTECFYKIKPSSRTKKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ74</accession>
    <name>A0A0N5BZ74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LsmAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ74"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ74"/>
    <dbReference type="WBParaSite" id="SPAL_0001106800.1">
        <property type="protein sequence ID" value="SPAL_0001106800.1"/>
        <property type="gene ID" value="SPAL_0001106800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="3">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001106800.1"/>
        </source>
    </evidence>
    <sequence length="1152" mass="126890" checksum="3FEDDD9C3BB298AC" modified="2015-12-09" version="1">MPLRQSTENNDSRNKSSTIDVSPGKVDGVYTNGEMVRVFTYIHGRETKILTTDGEIIEGVFSSASENCDVAVRLASEESKKGKNNLLTLESDIKEKMQIPRDSIVSMTFELKSAKDSHTFATDLDYSKRLTNIKTVDDEEKEFVEWDDGGDGDDNLDVSMPSQDNKDHHYNGKNNKETGWSVDDMFKKNNDLGVKSTFEGSECLYTTVEVVGNHEDRMRAEELAKEIENNADSRKAAELENDDEEKNIIERKPAMNESNDVRSSGNQKRSNGHQRTSRNGPMLRSGGQMNKSNDNFQNQNNRYGNNRDGGRYQPPQKQYSNNSQQGSSTQNQQQSSQQQSSFNSNQRGQDFGNKYDNKQGNISGNRTLPRNNSGSLNQNNYNRPSNQEPPKGVIQRTKDLNNQQQKKTGDGGRSSNYDNNTKTNVSSSNTSGAWNRGPPPSGNSRVNSTQSDTTNIDNNHGNKNIKHDSSTRKESYHNDSQHLMKKDNNKGSRDVSVIESTTSSTSNIESNKKLESPKTEVKKELAQQDTVATTTTTPTVTSPSSKERDQQQGQRKKDDEEKDSNKKTDSSEASTCSNNNSTTSSTKSFKFNVDAPAFVPSSSINTNPPSSPSNVPTPPETINTNPVQAHIPPQPMWYQQTVFQGGSYMYGPPTHANIQHPFYPTYPPQHPSGINAGNPPMSTFVVGGPPPMAIPQGAVNQGSVVQIPVPAPDTNTQGQGNPPAGPAIQGVPGGAPQQQPPAVIHPQPAPHYTQHNIHQGPIHHQPQPHRYDGQERRDKKPKNEYRNKDRDHRDYHGSKRDDRYHQNEGQPMPPPATAYPGQIIQGYPQYSPYPTSHIIPIPYPYFPANTSINQQNIPPMSGASPIHYQIPPQQGVIPQQQPLGGGEVPTGGGVMYNNNNLRHGSQNTGHKPYTTTGDNNISNDSNPSNNTVQRHTHSPDSVHQQSRPGSPKASNNTTSNNGATHRSSPTLSTTSQHSYHQPQQILPIQSYVLPQVCQAPGPMNVPPGQGGHFNIPAPGPYQHPQGMIPGNNMMYYQTVVTVPPTPYQMAPPPRRNSMSHNGGNGQQMYNNGNNLQGGHLPPSGPVHHHHHHHQNHPQQHHHQMGGQQQQQVPPQQQHQPSHSQQPSTEGVNTTGSGNSLQQSSSTQSTNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZG4</accession>
    <name>A0A0N5BZG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZG4"/>
    <dbReference type="STRING" id="174720.A0A0N5BZG4"/>
    <dbReference type="WBParaSite" id="SPAL_0001115400.1">
        <property type="protein sequence ID" value="SPAL_0001115400.1"/>
        <property type="gene ID" value="SPAL_0001115400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001115400.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="54263" checksum="08E505C8A7840291" modified="2015-12-09" version="1">MKNKTYSAVRNGILNCTPDGVKCKLYCKGKNCKYCNSNDWSENETAIKGIYSNWITKKILGMARPTEKAIKKFNIIEQFKSNNIRTIVNLQTINEHSHCGPMLHQSGFTYDPEQFMKSGIYYYNFPIPDYEICAIKFIRCIMKVIHFSLSEGNVAIHCHAGLGRTGTIIAAYFIWHDKLNYDKAIEIVRQNRPRSIQSKMQVEFLKNFDNYCHKYGVLLPKIKKKSFSWLIENQKLSLPTPQCHQYGHILKSVHEICKRLLKEIFKTNYTFNKVDNDNCYCIIGKLKVNWFPAFTVHGKSVIRYIVNLLETIHLISDDNETKEILKKAQKSNIITFDKDIYLYNIKELLIILEAQMQLIETPIAMKDELISVFSCNGSMQLNYIKTHDSNNSWICFVQYLCQVFSVIMGEYYDNFVKILTRWLFGNEDEDIKFVLFKYMRDLFASHLDDQQRIKNINDGIITEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZR4</accession>
    <name>A0A0N5BZR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZR4"/>
    <dbReference type="WBParaSite" id="SPAL_0001125500.1">
        <property type="protein sequence ID" value="SPAL_0001125500.1"/>
        <property type="gene ID" value="SPAL_0001125500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001125500.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="65964" checksum="5F30C5B5A6255EEC" modified="2015-12-09" version="1">MLVSSESQKPVILEKAGNGKTSCEIVFDCPELVTMVYKNLSDLKDKSNFIRTCKTFFNSVEKIKSLPEECGLNGDFFDINDVISIDDTVLHLHRDYLVITPGRREIHDGQLVNNVNKKIKMNTKNTRKLYISPYLRNWNQVTRKLNSFENIKHLKIGWDLKLPKLNFFNYLTTLNPDTIYLMDRQCTLFARDGRNYKSSNENWSFPRSVKRFIIKYRGCLPISRLLEGLSNFGQNEIDFLELIPTCFTKSDFINCWNKFIRLTDYFKRIDITSNYIIYEQGFYNCMKRLSSIDNNSKFWFNLKANIDSSFWNEIDHQICLKVRLLCILNNIVEGRYVDENLASTIYRTLFMMHGLETLMFGFTITDLGVNFASFIHNVSRKLKNIQITDCEKMKLIDLQTMAAHFKDLHTLSLHGIKSDDITLKEIFDLFPKIKVLEVFYKKSFKDSQVLDFFKGQKLNDGSYKFVWPKTVLLNIFTYYPNEEEFHDFQMVEKTIPRKSGQLLYSPDRSYFKGKTDILRVTLQQSSGCYNHLEVFKAYSCEMFYELLFYQDLLYGFENCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C179</accession>
    <name>A0A0N5C179_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C179"/>
    <dbReference type="STRING" id="174720.A0A0N5C179"/>
    <dbReference type="WBParaSite" id="SPAL_0001175700.1">
        <property type="protein sequence ID" value="SPAL_0001175700.1"/>
        <property type="gene ID" value="SPAL_0001175700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="2">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001175700.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18621" checksum="A1D38960B176585A" modified="2015-12-09" version="1">MNKGGIDKADQLASSYCFMRKSCKWWRKIFFWGLEVFTINSYILYKVSTRRENRTPMSHFMFVRKLVEQLVGDFRDGASSKPGRPSTSDKEERLNGKLHILRHCEDVKSKDCIVCSNRKIRGGRRQTNYFCDTCNRKPGLHIGDYFERYHTMEKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2C6</accession>
    <name>A0A0N5C2C6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
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            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="4">Belongs to the globin family.</text>
    </comment>
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        <property type="gene ID" value="SPAL_0001213600"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
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        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF16">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001213600.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34635" checksum="53FD81B8F357E9FC" modified="2015-12-09" version="1">MGNRHSIKNEERSSSDEGSGLSYYQIQAIQRAWRHMSKGGQASCGRRIFQKYATSDNLPICQDKPFEWGILKHGEEIVCFLTYIIKNLGNLEAVEEKCQDVGRSHRKMKQYGMKEEHWDVFGEALSETISENYAWKKNRQLLKASNILANFVVDRIRVGFVEKEGNTIKLSVNYSIPENKSRDSSIKLYNTIGNGEICYKKNIHSPLETKYPINHNLIRAKSFDTNANPKRRILPGIPNFEARKIEQQDNLHNFQRRSSTTIVQYNRSTIFNRSRPCICNFTNIDYDLEGNITKCKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2J8</accession>
    <name>A0A0N5C2J8_STREA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2J8"/>
    <dbReference type="WBParaSite" id="SPAL_0001220600.1">
        <property type="protein sequence ID" value="SPAL_0001220600.1"/>
        <property type="gene ID" value="SPAL_0001220600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001220600.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="24019" checksum="979560527402FCF5" modified="2015-12-09" version="1">MKIKYPETKEIEKVNFSTVKLLDHPLKLGENRKLADKKPFVGEKVEQSSKMGKKLFPQHDDKLTLFSSKDSGGLRKRKRDLYIKLKLDGDEGQELNKDGELEWNEEQELDEDYEKEWDEGQELDENNEKEWDEEQELDEDNENEENEDKEPECYKDKEPEYDEDNMRIDEFLDIMRKAFTNNDTENNTVKKEDPIKSFRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C382</accession>
    <name>A0A0N5C382_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRC8_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C382"/>
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        <property type="protein sequence ID" value="SPAL_0001243700.1"/>
        <property type="gene ID" value="SPAL_0001243700"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001243700.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43994" checksum="81393C3767697FC4" modified="2015-12-09" version="1">MMVIYNWVISQNCKYDKKHGIKGSFKNIISHSIVSIFVITLCFGYILFSMKGIQVFEQVNYSNMNLSVYEYVEIDEKLHWIALQCVLQNLIFPLAIAPFIVVTCYVILRNRYFKFLMCFFFLLEFHFSVFPLYDHFHRIFKVFGYRVEEYSLLTLVTSIVTIKLLSVLLIGPNIGSFLFTIFLIAIISLSCVLIVPYELLMAMFMVVSICILLVLLQKIKATLENQFRRMNDIEKKRKIIALPTYYEIEPFLSVHFKFLTPKASSIIESLMNKEYEELICNDKYKTIVAMDIYRTPIYFWDLLFISVLFGKIVLLDDYLLMLIGYISVILGLLFTTKLQIDYRTLLPAFPLSFVFAMFSTFVIHQLIYPVIHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Z7</accession>
    <name>A0A0N5C3Z7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A0N5C3Z7"/>
    <dbReference type="STRING" id="174720.A0A0N5C3Z7"/>
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        <property type="gene ID" value="SPAL_0001268000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001268000.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="58791" checksum="91AD6BE0BC944E42" modified="2015-12-09" version="1">MNNRKEVQKGSIMAARATASCIRTCLGPRAMLKMLMDPMGGIVMTNDGNAILREITVNHPAAKSFIEMARAQDEETGDGTTSTIIVAGDLMAKAEQFLDQNIHPNTINKAFAEALNLIIDKSNTTLSRTINIDDNEEIGKVVKSCINTKMMNNFMDFAVDIAINAIKTIAVTDGATKDIDIKRYCRIEKVPGGNIEDSRVFKGVVINKDVVHPKMKRRIENPRVILLDCNLEYKKGESQTSLELMNEADFTKVLQHEEAEVKRMCDEIIALKPDLVITEKGISDLAQHYLVKAGITALRRLKKTDNNRLARATGAVIAHDTKDLGEENVGTLCELFEIKKIGDEYFSYITSSKATVSTILLRGPSKDIINEVERNLHDAIYVVRNLLLNPKIVPGGGAYEMALGSVLRSAHASTKGLVHNIFMAIADSLEVIPKVLIQNSGKHVGGEVLKQTTELRFLHSQETTDSKKENWTYGVDGITGKIVDMNVANIWDPLTVRLQALKTAFENCIMLLRIDDIISSTKKKDGEPTATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4P3</accession>
    <name>A0A0N5C4P3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4P3"/>
    <dbReference type="WBParaSite" id="SPAL_0001292300.1">
        <property type="protein sequence ID" value="SPAL_0001292300.1"/>
        <property type="gene ID" value="SPAL_0001292300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF877">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12 14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015024239" description="Zinc metalloproteinase" evidence="12 14">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="169"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001292300.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53497" checksum="06CFCC244A665EB8" modified="2015-12-09" version="1">MFFIKEFILLAIAASFIEGRRRFEIRDETRKSLSDTSKKNFDDTVIGLERLNRIQRRLMRLKDRNETDDLNSEVTVESPMENLDLYEGDIMLTGNQVDEIVNGLVKQAEEKKIDVSDIESRARKPKRGKRSISSSLNNMWTFPIPYYVDTGVNATLVTAALKGIESETCIRFTKSATPITGKPGLRYYKGTGCWSYIGRIYTNASQEVSIGQGCGLNAIIQHETAHALGVYHEQSRPDRYLYVTIKTEDIIAGKESNFAGSIPGYVNEYGIPYDFGSVMHYGRFSFSKNGNQTIVAIDGKYDKTMGQRKKLSFNDIKLINFKYCNSTCPSTSISCKNGGYLDPNNCARCKCPLNFYGTYCQNYVTSPSTTCGNQMLTANTTLQFLTITGALNCYFVINTTPGYVIRLNLISTSLVNNDPCFSGKGLEIKHKTDKTATGINICGVNSYRIFYSESDSVLIHYVGTTATDSFTLTYIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C609</accession>
    <name>A0A0N5C609_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C609"/>
    <dbReference type="WBParaSite" id="SPAL_0001338500.1">
        <property type="protein sequence ID" value="SPAL_0001338500.1"/>
        <property type="gene ID" value="SPAL_0001338500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895514" evidence="1">
        <location>
            <begin position="20"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001338500.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="59569" checksum="91CA2316BF410E6F" modified="2015-12-09" version="1">MNVLILILYTYGLFSVSQGGFVDWLKDTWDDLKKLNFEFWNKHPASRILYEHVDPKVDPCDNFYRFSCGNWIKTKERKKGNSESFHYDSSTKNFDKFKDGNILFVFIYLFSEFIDGKYNNESKVINTLYKLRQKCKKLPIKTIFDCNLKILNFGRYALSSVFLKKNIIKSEEDGEYDTVENIIMLIKHEFRLLIDEKKDIFNEETRNNFKYKLDKMEFVRNFDKLDLSNVTSMESCYDNIGIDYNDHITDILEKIKNLKALSKKEKDNLDSCRGKIFQPKEFMLQYVYSDSWYDPYENYFSVNSNYLNEPSYSKNYPLSFNYGYLGSTIAHEILHAFDSKNFKLVLEGDNKNYFNISQESIENYKERSDCLVKQYGMQKESITNKNINGLLTLNENIADNGGLKIAHRAYMKYVQGYDGEKKKVPRFEQFTDEQLFFISYGRSFCEYVSKDRLEERINTDVHSPGEIRTNVALSNYKPFSDAFKCELKSKMNPEDKCELWKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C695</accession>
    <name>A0A0N5C695_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C695"/>
    <dbReference type="STRING" id="174720.A0A0N5C695"/>
    <dbReference type="WBParaSite" id="SPAL_0001346650.1">
        <property type="protein sequence ID" value="SPAL_0001346650.1"/>
        <property type="gene ID" value="SPAL_0001346650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001346650.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15071" checksum="C225B164787BB919" modified="2015-12-09" version="1">MFNTSYIKINDILCSSEYKSSFSGACAELVVVDGVLDLWHLEYLLIEQRKYLYKYFDDNVYENALMSLVKVPSPDVYLDLLDLLADGNYHTDIGEILICFLFKILTRIKKIVSRECGEKLRIIYDMYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6X6</accession>
    <name>A0A0N5C6X6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6X6"/>
    <dbReference type="STRING" id="174720.A0A0N5C6X6"/>
    <dbReference type="WBParaSite" id="SPAL_0001369100.1">
        <property type="protein sequence ID" value="SPAL_0001369100.1"/>
        <property type="gene ID" value="SPAL_0001369100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001369100.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30684" checksum="0BD51E5FE6A73898" modified="2015-12-09" version="1">AYQLPSLIQNIIRSCSICQITYQKCSKTHNWKECTKPLQRGHLDIGHCSLYKSDFFVLKDSFSNFLFADWIPKQDASTICNKLQRIFELTGAWSELVLDNQTSLAGNHMRQFLSSFGTKHTLSIVKQHNTNGAAKRAIRSIKDQLYKEKTLGNGKEMALRNTLTRLRCNPYKDGTPYTKFYNDPERLPNKTLELSLDIGTKEEIFSPPLDGYFQRKPDINKQWSKAKILKKLSKHTYLIEDIIDGTHHIRTDKCTKIIHKPSGKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7T3</accession>
    <name>A0A0N5C7T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7T3"/>
    <dbReference type="STRING" id="174720.A0A0N5C7T3"/>
    <dbReference type="WBParaSite" id="SPAL_0001399500.1">
        <property type="protein sequence ID" value="SPAL_0001399500.1"/>
        <property type="gene ID" value="SPAL_0001399500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926789" evidence="2">
        <location>
            <begin position="16"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001399500.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="71702" checksum="E09A7D08A4761291" modified="2015-12-09" version="1">MVLVLFLCFLFVVNCNYVGGSQCGNGTIPFSFEALKDGQPILGCAKATCLGWLPNGTHVGGDVKFLKMEGHPDGYLRSQDVKLEDIVIDKNSPQSIVRCEENFHSKHCGKSGEWVGGIKPVPYEKLLNTTLKMKCCSYDKLLDSYDQGVAEINPGQIIIGGEIFKNGKQVAFEYIADIHKKIEYGRILYTVTTRRFKCGKATDDNKQHIGRRKLKKINVLMKAKIDKEIVKKQTINKIKKDKNKKNFAEIAFVKLLEEIQLTENAITKGKMSKTNRYKIEYKKHPKKDIRMSPRKNINLDVVEVNESNRSLKPRFQAYWDASENKWKYKTFTRSEGITKYDGDILFPSSDSIISESFNEKKDEQIPPIPITVKPRFTKKAYETDVYVKIPKRTSEEPQYPITERLKLPETPTTAAPTFPPTITSTPELPPQRTINWFGQQLVPGKTYKCQKFLNLSLHTTTSTPELPPQRTINWFGQQLVPGKTYKVYDTITPELSYEFTVPEIFEPLATLPPQPPIPGAASNPLDILNTLQAQPPTLEQALRTILSPPPHPVPSDIRRSPVLHDIPVTTETKRDGSIIHDRPQPNIVIEQVGGKVNPAPQKNINEIIPEGGREIFNNIAKTLLGEYYNRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C861</accession>
    <name>A0A0N5C861_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAM86 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C861"/>
    <dbReference type="STRING" id="174720.A0A0N5C861"/>
    <dbReference type="WBParaSite" id="SPAL_0001411600.1">
        <property type="protein sequence ID" value="SPAL_0001411600.1"/>
        <property type="gene ID" value="SPAL_0001411600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001411600.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25908" checksum="000D5D9D1CC10C69" modified="2015-12-09" version="1">MDNVDKDKVSYRVYFDENFKNKIIIQEYVEQLSCGTTGLSCWQASSVLASVICFDNEFKKKYNFKDKSVLELGAGCGLTGIAIKVFAGVGFLKMTDCNELVIKQLMRNVEINKLDCKEVSVSYLNWKDEINEVSNYDYIIAADVIYDTSILDSLLKTVSVLLKETSSTFIIASTLRNQETIEKFENQIVRNNLLLLERRILDDFKNVYLPFSTTINAPTIIHFLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8I6</accession>
    <name>A0A0N5C8I6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8I6"/>
    <dbReference type="WBParaSite" id="SPAL_0001423200.1">
        <property type="protein sequence ID" value="SPAL_0001423200.1"/>
        <property type="gene ID" value="SPAL_0001423200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001423200.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28894" checksum="FFD6DF5CC94F7701" modified="2015-12-09" version="1">MSYHDRFHDSLKNLQLELTQLCFPPPEVIIHQSVVPNINSLSIKYDFDIERTVVEDSEKKLKKLKDEKEAMLLKKLAIQNVYKTNILGGKCCNDLNSSPVTIGGEDLMDQVDTCSSLSDSISKTSSLQEDRLIDSTTKKEYSSNESFTNMKMPLVDLSEFETPNTVFDMVALKSIDDKAELEALLSSSSHYSGTLEMAKENGNSKNRELEMEVVKPSIVIEVTKPTTNRNVQHSENLFQYPSMPSFSFNDFKTGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8L5</accession>
    <name>A0A0N5C8L5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8L5"/>
    <dbReference type="WBParaSite" id="SPAL_0001425800.1">
        <property type="protein sequence ID" value="SPAL_0001425800.1"/>
        <property type="gene ID" value="SPAL_0001425800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF12">
        <property type="entry name" value="CHITIN SYNTHASE CHS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1178"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="16">
        <location>
            <begin position="33"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1085"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001425800.1"/>
        </source>
    </evidence>
    <sequence length="1322" mass="152126" checksum="0211D8E7E6D2F6DE" modified="2015-12-09" version="1">MVLAESEGNSQYKWDVFKSYPRAIYTAHLQDSTKSNYFLQCFRLTVYIVSCLLLLGGSVFSRSVVYILSTNISNMTQIEIKDLEKCRANAKDFGIEIGDYAEKRNDVIAAIILSLWFIQTLPDFVEAVRSFSSYFLTKHETIPIVKSFIVFETLRSAASLVIVMFLFPNLDLFRCIFLTSSFAFAPISLKMLSLLKKAIIDNIGIGERMLWLMVCVPLSYICCSFFTTFYIWDFVGYRIYNDISLLLWIPVLGFCFWESWIFKSSANGVFDSLFRIKYGLQKVNSKTRLITALCRIFASCFVFSKAVEYHKINDILVSDFLLQLEFSTQAMSIFWLSGAVVVVNALLRLSIRLLSAMKMQLTTLWHPYVLLPITSFWVIYIAQYEESKCFIDTLLSDYGLAIRGDRYTTPESDLIAYDFYIGVLWFLCHIIWAFTFIENKKTSKRHEYIEAVAPNSNGLFIDQSLLVFSHRIKKKTNINYLDDGHLIDDALLGDYHIKDGERIDDVINNTYDNVPTIYACATMWHETKNEMKQLLESIMKLDEERKKLEGGRLGENSYFNLEAHIFFDDAWVDDKLCGSIPNEYFETLYGLLKELLNWDEPQKDEEEDEDNSGSQKTEEIVRILIQTAYGGRFVTKFKYGTVLYVHLKDKRKIRHKKRWSQVMYMYYLLGHRIMASDISSQDRKMVADNTYILAMDGDSKFKPEAVLRLLNLMRMKDDIGCACGRIHPIGSGIMVWYQKFEYAIAHWFQKAAEHVFGCVLCAPGCFSLFRASALMDDNIMHKYTKVAKEARQYVQYDQGEDRWLSTLLLKKGYRIEYVASSDAETYAPEGFEEFFNQRRRWTPSSIANTIDLLLDYKVAVANNAAISKLYILYQAIVIGFSMFGPAIIFTMIVFAQTAAFGVSSDKMIWYNAIPILGFIICCFLYESSTQLKFAKTASIIYAFVMLSVMVATTSQIVLETIFSPTSMFVVNMIVIFLFAAVIHPNEFTNIIYGSVFFLMIPATYIFMALYSLINLNVINWGTREAVAKATGTTTTVEDPIVKILKKFSNKIGLDKVLKLFYNCITKRNEEYKEIKEAIQSLKSKLENPENDQNNEIKEERDVDNNINSVEPPPKEKIVYQDYTWMDTEVLCECSKGELGEAEDNFWHELIDSYLAPLRTTKEENQNAANCLIDLRNKVAFTILILNALLVLAIYLLQKHKNVLSFEFRPFNGFEWTKLNEMTGQFEVTTDALKIDPLGLFIIVFLMGILVVQTFGMIVHRFNTLIESLSEIADAENEFLFSTTNVIDHDEVIEIAQSMLNTVDYETAHGAIGYRRPGKNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8L8</accession>
    <name>A0A0N5C8L8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8L8"/>
    <dbReference type="WBParaSite" id="SPAL_0001426100.1">
        <property type="protein sequence ID" value="SPAL_0001426100.1"/>
        <property type="gene ID" value="SPAL_0001426100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001426100.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28558" checksum="876EF4D282E7E724" modified="2015-12-09" version="1">MSAYLGWSEDKPSKDYVRLHKQYDTDSSIGGPITNSYEDYIKSIFKNSDSKNKDNTLPEEYRMPQGITEASKGISARVMLKMEQHFGKHALDNLGDMNLDLDTKHHDPLDDLYSEIGINRPKETKYSEYVVYKPKCSSEYFSTLNRREYPVYSSTDCKGAFKSFEAQDKNDWRNNDRQMLIDYKQFDSSPLSPYMYKDHQFLKNQDSRIVCSNFVQLTTRPKDRFLEKIDKTLAEVRAMPRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8L9</accession>
    <name>A0A0N5C8L9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPI2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8L9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8L9"/>
    <dbReference type="WBParaSite" id="SPAL_0001426200.1">
        <property type="protein sequence ID" value="SPAL_0001426200.1"/>
        <property type="gene ID" value="SPAL_0001426200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF139">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="309"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001426200.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="59945" checksum="036D9C522F295F77" modified="2015-12-09" version="1">MSDATSVTDEKNQGLPGVKIRLTSNGVSFISKVTANILITEVITAVVDLPPQKVQFDGGYVELQNLKMEMKESKHNVNSKLIPPNNVSIEVSDLGININGKVNGNINGNNNFMGDVSLSNNGFKVLLGINILSNNHGIPNIKLNSCKIKEDVTPKITANINLLKADEKEKIELGIAKKNNEILESMICSRIEIIIEDRINDRFSLIPNKLPMNVLAETAILEEVVSKMALRRRQIRNVENLRLKRQALRSLSSSFNLTKANNLLLDYGIVGEPKIVNNILEIDSVSEISLNGRGGTPFGANKFIYPEDVKNGVMMQLIVSDFVPNTLMYHGHTIGIFNTRIDSKTPHFSTMMKSSCSISSGVLFCLGDLFPTLKRTFPNRELAMLYKTIKAPVMKFHDKTSGGVKFNIAGQITILGIESNGEEKPFGSFIIEVDSSMKMRLSNTMTKPKVTIENMKFTTESPNVITQQELNQAGILTKEVLQRMVNDMLKEGIPIPIHPLYKLDKPRVRIIERAMLIQTNFKLNEKLLRQLTASEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8U6</accession>
    <name>A0A0N5C8U6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8U6"/>
    <dbReference type="STRING" id="174720.A0A0N5C8U6"/>
    <dbReference type="WBParaSite" id="SPAL_0001433200.1">
        <property type="protein sequence ID" value="SPAL_0001433200.1"/>
        <property type="gene ID" value="SPAL_0001433200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001433200.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27389" checksum="822EC761B61DAF8E" modified="2015-12-09" version="1">MGSTVLGELDEKIDNNVDNINEWDTEIDLDSLNKTEKEQKRKEREMRHKERLMEQQKRLKEKRDSDMLRFPAIFDVIYSKRLISTSSYLLKTSAGKTKPTLDGSQMMTYEMSQKPYHIGSRKAWLTWHTHNLEEFRKSQGSIIAQDEVIRRFIHGFFPKHITMDGNEIVIKRRGNSIAIAGFLQYSHHLNIKKIYWMFGFTEEFLSILLKQPVTLEFQFVEDETELAYNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C971</accession>
    <name>A0A0N5C971_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">Glutamate 5-kinase</fullName>
                <shortName evidence="17">GK</shortName>
                <ecNumber evidence="17">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="17">GPR</shortName>
                <ecNumber evidence="17">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="17">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="17"/>
    <dbReference type="EC" id="1.2.1.41" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C971"/>
    <dbReference type="STRING" id="174720.A0A0N5C971"/>
    <dbReference type="WBParaSite" id="SPAL_0001445400.1">
        <property type="protein sequence ID" value="SPAL_0001445400.1"/>
        <property type="gene ID" value="SPAL_0001445400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04256">
        <property type="entry name" value="AAK_P5CS_ProBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000011">
        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000006">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041744">
        <property type="entry name" value="G5K_ProBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 17" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="18">
        <location>
            <begin position="79"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001445400.1"/>
        </source>
    </evidence>
    <sequence length="782" mass="84669" checksum="31BA27ACE665ACC7" modified="2015-12-09" version="1">MLRFASRQVTRFVASRSIKTKTDRLLVQTAVPAVVNDDQGHLMGLSELGLRSADGTFDPSEMKHQHRNINNRADLIKAKRIVVKLGSAVITREDECGLALGRLASIVEQVAELQLSGRQMLFVSSGAVAFGRQKLRHELVMSMSMRQTLRGPAGINADKRACAASGMPGLMSLYEQLFQQYGITVAQVLLTKPDIDDPQRRKNLRATIESLLNLNIIPIINANDAVAPDPKLNMHISDNDSLASALSSEINADLMIILSNVNGVYTGPPDMEGSRLLNTYNLQASGDVVFGENSKFGTGGMEAKVSACVNAMKHGVSTIITNGSSTNAITSAVYGKKIGTLFCRGGNDEGPPIEEVAAVTKESGRALQALTNEERSDLVKKLADSLIENEQLILEANRLDIHNAQQNELEPALLNRLRLNHSKIADLHAGLNMISDSAKTLIGKVLKRTELTNGLILEQKSVPIGSLLVIFESRPDCLPQVAALAMASGNSLLLKGGKEADESNRFLHSLVQDVLGKHSFELRDAVTLIRSREDVADLLQLNEFVDLVIPRGSSEMVKKMQEQSKGIPVLGHAEGICHVYVDKECDENMALNIVKDSKCDYPAACNAVETILIHRDHVNGKLFDQLCGMLKSEGVKLHAGPKLQSILKFGPPAAESLKFEYGKLECTLEVVDSTEEAIAHIHRYGSGHTDSIVTKNAKTAKQFLNGIDSACAFHNASTRFADGYRFGLGAEVGISTGKIHARGPVGVEGLLTTKWTLSGGGHTVGDFKTGKFSYTHKPLPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9E2</accession>
    <name>A0A0N5C9E2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9E2"/>
    <dbReference type="STRING" id="174720.A0A0N5C9E2"/>
    <dbReference type="WBParaSite" id="SPAL_0001452600.1">
        <property type="protein sequence ID" value="SPAL_0001452600.1"/>
        <property type="gene ID" value="SPAL_0001452600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002997">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="29"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="239"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001452600.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32691" checksum="B02EE4BC16DF8E9F" modified="2015-12-09" version="1">MYNDILTKMYDVKVVSKKLPDALIIGVRKGGTRALLDALSLHPMIKIARHELHFFDNNETYFKGIDWYRNQMPLADENQIVIEKTPAYFTTPYAAKRIYQFNPNIKIILILRNPVTRVISDFTQVYYTRLSKNLSLPQFEKEVFFEGTNKININYKPIRNSLYSTHLINYLKYFEKNQILLLNGDKFIKNPLNELKKVQKFLRLPSMIKPSQLIFNSQKGFYCFKKEEQSKVKCLGNSKGRKHVNVSLKTKNLLKKNFKKYNYVLKTLFNDFDFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9S8</accession>
    <name>A0A0N5C9S8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9S8"/>
    <dbReference type="WBParaSite" id="SPAL_0001465700.1">
        <property type="protein sequence ID" value="SPAL_0001465700.1"/>
        <property type="gene ID" value="SPAL_0001465700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001465700.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8978" checksum="6DFA32B8CF379C1D" modified="2015-12-09" version="1">MFELTDTQHVIMSLILHLIGINFGIWCWYLFPKNPHRQINRCANRVEVKLNNNLESRNLITLNPLSKEAINNRYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA01</accession>
    <name>A0A0N5CA01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA01"/>
    <dbReference type="WBParaSite" id="SPAL_0001472700.1">
        <property type="protein sequence ID" value="SPAL_0001472700.1"/>
        <property type="gene ID" value="SPAL_0001472700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001472700.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="75560" checksum="88C89EA4A58B0287" modified="2015-12-09" version="1">MNRNVKYRSIAYGTWHIGDARKFVEEKFNGSKNKKCEKKQSSILPSKNEMILNKIDKNLLSLKISSDGGVTFKDDLRSVTPIMEISTIMNSSPSFDHYNQEDNSLTVSTTEANSFQFDSLNKRKKISINNQHSMADSGIADNSDSSPEGDWYSSSEYIQYCQKMQQTANTEDDFSFSSTITNTKKDDNNHHHCSLETIYQNSVSPSTNNIMMTKKNNNRPTITNNTHLKPLKDNSKFTIKNVPSSTIRTPITGPRQMISTNNDYNYYYQQPSSLNYCENNLICNLPKNTIHYNNYHKPYYDSKLYKMANFLPQQNNENPVNCIPFPMVNDSMYNSHGNSIILDDNTRYYNTKTLFPYDEKLNYKSNSIDKRRAKSVEIGNTYSTVLNDQGYNTMRLKNFTNQSNNIKIYNNKHESLKNWENNSLTYNNCDNKKDKTFSAIKSTKNFFQRIFTNPTSTLPRKWKKGNDKSNFKNEETIVDDWTHVNALTTMHKYGTIHRTKTDINCLLNNYDILRKQYQQNGYSSDFIYPFTIDNIYKDIKDLSIPQSSSQKSSSDSCYTSTISSNSPTHQTTNKILIGKFKVEERPLIRDERYYDKVYPSFENFKNWNEIYHYLKNELQTIKEKDHRILENLRYTEEQLNEYKKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA32</accession>
    <name>A0A0N5CA32_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5CA32"/>
    <dbReference type="WBParaSite" id="SPAL_0001475700.1">
        <property type="protein sequence ID" value="SPAL_0001475700.1"/>
        <property type="gene ID" value="SPAL_0001475700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="452"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1248"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1248"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001475700.1"/>
        </source>
    </evidence>
    <sequence length="1292" mass="149662" checksum="5B915848F2325DB5" modified="2015-12-09" version="1">MALRVDLPYFEMKDTSRAEAFVKFMEWYLKCEKDKDGKEISDNLRIQKFLTRLDLDAWTRVKEEISVYSIEKNKREENLVFDDYVGVFKKIFMTEKNSYIELVTMLKSINEKVADVDKLYEEITSVLRKTKMSSITMEELGGLLMILKFAAPEAMEPLLLKKAAEERLNNKSERRLAYAKEILDIIKELNTFSLALSSSKDSVHRVYTKSNDKFKKNTFKRKTFNKKIQCHRCNKYGHIARNCNEVIRKIEDNTSDIENESDDDEVVSVVGRIEGEKQLILPVKAYIGKKNCFVIKAEADSGSPRTFIARNQIPGVGGGEMATCGKIKMILEVNGKRVETDAIVTTLNYSLIGRTELIKLGLLDGLKDVCIKRIKSGINNDGNLEKIRVNLEMEIKRKCPNLIDGKLGCYVGKPIKLPFKEDSKFVIVPNRQYNCLEIEPVIEEKLANYEKEGLIKREKYPDAASPIMPMIKKLDQPVDKNNIRIVADYSLLNRNFKLNCYKMKSVDDVLRKVGNMMNSKKVYISTFDVQDCYGCIRIDQSDQSKVCINTHVGIFRLCRLPQGVSVSPPICQEIMDKIDKQVTEFCRKNYNNFNNGNDFIETYYDDTIIITELLEDHKRAVMCYCKTMEEKGFKLSTSKWKVLTKSTMFLGVKLCEGKFKPDERKIACLKAMTIPKDKDQLISFLGLVNYHCKYVDSLAQLRQPLDVKRRKDGKFEEFSDIEKKSFDDCIEAISNCNGLYPYRKGMKLIVESDASDTAMGAVLKAESGEIIEYYSKSFTATECRYPIQHKEALSCVLAIEHFKYYLMLKEFQLHTDHESLAICFNLEKGIKKSMSNRLQRFALRLMPFHFKVYYVSNKRVLCADTLSRLICEKRKDYLEEFLVCKIHSKNELYLRESQILKEAEFDQNYLLIRDKLINNESITHLGERFLDATVEDGLVKLGNQYLIPKSLHQRCLEILHTSHQSSSTMKRLARQFWYWSSMTKDIQEVYDKCEICNDNKIMPNKSLPFMENSLYPMERVHIDIGECFSIYFLVLHDSFSGYLDIFSLKNMSTTECLSCLNRAFSYLGYPTSIFSDQGRQFISQETKAFTLKHGITWYFSGAGHQSSNGAAERSIQTVKRLMKKLHKPGCDIDELFIKIKVNVNNVPSGKRQDSPNNLLFKYNCHSLVRTNEYLEGIPKFKIGSLVKFRLSKDKKWENGRIIKIHGSKLYDIEDSKNHIRFMHQDNIIESSANLNHLYYEDTINEQNKKETDPISTKERDYGKRKARKRSSPPLEHPMITRTKKRKGMIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAD2</accession>
    <name>A0A0N5CAD2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TFCD_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CAD2"/>
    <dbReference type="WBParaSite" id="SPAL_0001485400.1">
        <property type="protein sequence ID" value="SPAL_0001485400.1"/>
        <property type="gene ID" value="SPAL_0001485400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="401"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001485400.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="78725" checksum="42BA16027BD1EED5" modified="2015-12-09" version="1">XTYSPDLLKPFVHRLATRLVTVSLFDKELNIRRAASAAFQENVGRQGYFPSGIDIIHIIDYTSVSRLSVCYNELCVKVAKYEEYLKPMLDHLVEFKVGHQIMKMNERACEGLYHLVKLDIAYSRTVILEKLLKKADTVNCCLQYKVMKAIESVVRSLTEEDSFDVSNKDNPFTLERVLEMNKKLVKEADTTSRNKRSTYAKLSLSYFIKICCECGMALSDGVYLKWLELLENFTEENSIELRDGASMASKSLMEKVAGISTIEIDKRIEKRYLHPLKENRFDLTLNKAVLMISSLPNSLLNENIGNELIDFIQDKMRLHLMDSRVYALNCLKERFIESELLKVLSFTKIIECLNFCINDFTCDPAKGDVARFIREKAIQTIISFVKQPMLYDKMSSDIVCKFIGNLLIQACGKNINLRQIAAQAIHDILTAEPSLPILEVEALREIFILKDLNFCEIFVYANVFDMLSQLLDNNVYGSYIRYGLVMSSGYHNGCEKEKINQIITDYFENSSIDKKLDIIKELRTEILRKKISSRVIKSILDFLDTYLIECFEFIQEDLDSFKDICEILKYCCFLVNLKQKPSTSKSSTLKEYAGKVLSFTILCNESSSMRKKSLESLCTLLEGTNEVASFEVSKKITEYLVIVDEDIINEEDKETAINLLSNTVWDGDSKAIQTTTETLRRIFKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAT4</accession>
    <name>A0A0N5CAT4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="STRING" id="174720.A0A0N5CAT4"/>
    <dbReference type="WBParaSite" id="SPAL_0001500300.1">
        <property type="protein sequence ID" value="SPAL_0001500300.1"/>
        <property type="gene ID" value="SPAL_0001500300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06370">
        <property type="entry name" value="PBP1_SAP_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="643"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="989"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1349"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1366"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001500300.1"/>
        </source>
    </evidence>
    <sequence length="1543" mass="178428" checksum="3164D9EDCAA26041" modified="2015-12-09" version="1">MENFQYMIENGKLYGIVEDIKSWNKIRKERDIKDNDIPNNKTIITISYLSAISVFPKNLYDYIKNVTNSSINNNSLIKKLDKLNILSDYNYVSKCFRADFEGSLISGALKFAVDEINSNPDLLPDYYIRYVYNNTCGDEILSTKHFMDHWKSGVSAFIGPEINCKAEAQMAAAQNLPIIAYKCKDEVVSNKDKYPTFARTVPAESAIAKTVIATLKQMKWKKVAIVYEEASIYSKLVDSIKLIMEQQNRHLKINKYEILSVNTVPSPFSEFNENKFDQIVDETKDFSRIYLAVGTPKMGRKLTQALGDKNILSGGLYSILIVCPDYDWLNTYHAMNNHFFRDTSKWLSKSWDVNNSDDHRFLTYARHMLAIIPTPVSLNNPQVKVFWKKCNENLKFFGIFGNPFEKEIKPNRHAYFLYDAVMLYAKSLHQVISYYKENDLNPNLAIRNGQMIMSHIIGKRYFSIQGFEMRINKNGNAIGNYSLISLQEVAPIYDKTDPNYYPVKFALDVTADFIDVDDDLLTLPKIRYHRKIRWPRIFPPLDEPKCGFLDDKCPVNIFFKYIWAFFFFFFFCLLGSYLGFKHYYERKLRLEEIPDIWKIDPKKIQKVSKTHETLKSLLFFDEDSEIYSDELSKLLARYIPKSTAKRNKLSQSGNSKFLKLSGIGVYEGSFVVVKEFTYDHDKKTVTDLLKKECNAIKQLRNDNINNFLGLIVGPYSIYVVREFCDRCSLMDVYRNNDFKLDNLFISSFIDDLIKGMLYLQNTDVKIHGNLKSTNCLITNRFALQLSDFGLYELRYGQDFKTEELMWEGLLWTAPELINFDDVSRPKPGTQEGDVYSFGIILHELVTGDGPFRLLSKNNICAAEIIRNVVEDDNFRPDTKFLNCPKFVIKCMKECWKKCPKSRPTFQNEIRRDLLPMLEQVMKNSLMDNMMALMDVYQNQLEDLVARRTIQLQNEKRKSEALLQRMLPPSVSNQLITGGKVRPEFYESVTIYFSDIVGFTDLSNFSTPIEIVSFLNDLYTMFDSIIKKYEVYKVETIGDAYMVVAGCPKYYSASKQAEEIASMALNVLACSSTFVIKHKKNEKLLIRIGIHSGCVAAGVVGKTMPRYCLFGDTVNTASRMESTGSGMKIHCSIDTRSLLESKDNFLFQHRGFQNIKGKKPVLTYWLLGRTDWNDDKSINIDTPNDESNISVSYSQKKCKRAKEKMNENQKISISNATKKKSTSNRSLNKIKYLMDRTKNKYDNGLVNEELNKKDILTNKYTNIINKAQRSSLTKSFSLPILNQSKSYLWNVRNCLPLKELSRKSCMSSIKSILDSLISDDDYNTNISKNTIENDSFNSLNDITGYTNKNSSSENSITSLDDCKNFTDDNEDEEDKDDDNDNEYDRSYDNKQKLLNNKVKKKLSNGDTLMKRVKRLNEYDSFTAYSRSLKNSTFIEYKSLSTHSSCDGYMDRYAVNKSQLNDDYEYDLEAAKSWNNSTIKNSYFPVKRKKISKVVKNPKNDIDKQEIDSYKESLITKALLIFNQRRGVRKKNKSNYYVNGNDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAV7</accession>
    <name>A0A0N5CAV7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-cysteine protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAV7"/>
    <dbReference type="WBParaSite" id="SPAL_0001502500.1">
        <property type="protein sequence ID" value="SPAL_0001502500.1"/>
        <property type="gene ID" value="SPAL_0001502500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895687" description="6-cysteine protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="3">
        <location>
            <begin position="230"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="348"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="444"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="606"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="705"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="798"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="874"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001502500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="126029" checksum="09A9EBF8CD8956C6" modified="2015-12-09" version="1">MGKMLKLLWILAVFSIYKNSCQRPDRFKRQFKYYSENETYDGIFPRNQTVMSDTNTIALKCPLSHSAKRRKPGTDERSHIAIYENFDDNENNINIPKTDDDIYVWKFVSIEKNQKMKKINCLNIYINNISNLIAEWSHLIRRTDGQKLNIKRKKDLNIILHSHEKNIYSFGVSEITFVSSVLWGYRNFDSRQTFLFKGEILVTFNADKINSEDIEFQEPIGITQVYHPPPFIDIQNDPRIKVNAKNKEWWFVEPHSFPWTFTIKLVYNSTTNQPGFFNNENITVSYLRYSKDNKLREIKKDILKPNNPNTRNILLNESAIIKLNYFCDNCIEGGIDIVQNMIIGKNFDFENTVLPSVEYVYDKLNSEANCPMNLNNFTQLKTVSFNNEMIEVQALYGTNDEAKGNFSLSNGVVKFKNTNPSGTLKCTYIYPAGEFHTSQTYKSFKDEEMPSITYVYDKLFFKPNCSMSQGKSVTLKTVLFNNEKVEVKNFQASGNQMGNFKLNRTFVLFTDTNPKGILSCVYKLFNGEYSITQTYEHFKTTILPDVKYASNQLSFKANCSVELKTNAILKTISLEGNYVTYMDKNPVGKCVCVYKLSFGDISISQNYESFTDENMPLTTYRHDELHFKPNCSLKLNNFSILKTVSFNNEKIEAAKLQGTGGNQEGNFKKDNKFVVFTGTNPNGALSCTYQLPYGEFSKYQKYKSFKDQNIPPFTYLRGGLRLTPNCPMDQGDSVNLKTVSFDEERVEVSDLNSRSDKRKGNFKSDGKFVNFLGTNPKGKLSCVFKLSYGEVSTNQSYGYFSNINHPIIRYASDQLVIRPNCSMEPEKNVNLETILFNDESVEADYLQNTGNNPKGKCTCVYKLQVGEIKTFQEYQSIEDTTLPDVKYAYDQLNFNPNCSREENTYTQLKTIKLNDKTIEVEGLNDAELIQMGNLKPTKDLLLYTVQNPEGKFSCIYKVPIGEIKKSQNYNPISNETHPVVEYSYNDLGYNANCSRHLNSFTHLRGIQFKDDKTTVVSLQRSRVGALGRLKLEKDFVINTEKNPNGTLRCLYDVPIGEVWVIKNFTTFKTGDEENSSKKMGYVASIILGYMIVISMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBC6</accession>
    <name>A0A0N5CBC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBC6"/>
    <dbReference type="STRING" id="174720.A0A0N5CBC6"/>
    <dbReference type="WBParaSite" id="SPAL_0001518900.1">
        <property type="protein sequence ID" value="SPAL_0001518900.1"/>
        <property type="gene ID" value="SPAL_0001518900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001518900.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15241" checksum="CD6B1287FF16DAC6" modified="2015-12-09" version="1">MVLFLPTKNTYDSYYRCDFFSLEHWQLEKKPSLGIGLLYIIPGSIFIILYIPILFVMMNKEFMKLSCYRIMIYLVCVDLMTLLHNSLLTGAFSILGSLFCEHRLLMFITGQTALFGWFAGCITVVVLALNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBM1</accession>
    <name>A0A0N5CBM1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBM1"/>
    <dbReference type="STRING" id="174720.A0A0N5CBM1"/>
    <dbReference type="WBParaSite" id="SPAL_0001528800.1">
        <property type="protein sequence ID" value="SPAL_0001528800.1"/>
        <property type="gene ID" value="SPAL_0001528800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001528800.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="56786" checksum="E19E059EC2EEE2D6" modified="2015-12-09" version="1">MIGILLLIIVTIYLINFYRKVKSLPPGPLPLPILGNLLSFDFRKTHLWIYNQKKIYGNIFTIWIPTPHVVFADYDSINAALVANDDNFLGRNVGGYPEKLISDRPNVGVIFSEGEEWRDQRRLSLHILRDFGMSRTIMQDKIHLVVNDFYEYVDSLEDKDNVDIEKILQLSVGNVINLILFGFMYSYTDNDEYFESIKSHESLIKLSASWEIKLLSLIPFIDKIPFLKNYLCRRVMGFLRKVKEMTNYQIELCKKSYNPDNEPPNFIHAVMKEIQSVGSKYSYLNSDHLEAIVLNFWLAGRVTTATTLKWFVLFIMKHLDIQKKLQDEIDEVIGRDRLVQLNDKAKMSYMNAFIAEGQRYANIIGFAPSHRCTKDTVINGYLIPNNTIIQPFYWGANMDEKYFKDPFTFNPNRFIDSEGKFKVEHEHMSFGKGKRICAGKSLADAELFLFFTSFLQKYKFTHPYGPVDLTSDSGLALIPRPFKCKIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBQ0</accession>
    <name>A0A0N5CBQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5CBQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001531400.1">
        <property type="protein sequence ID" value="SPAL_0001531400.1"/>
        <property type="gene ID" value="SPAL_0001531400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895749" evidence="1">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001531400.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45808" checksum="F6D15616C9020A52" modified="2015-12-09" version="1">MQKLLLLAILGLTVSTIYCDSGSGSGSSESSEAKDLKKKKECAGDVVDETGDSGKPLLIEALFNVSITLTGEDKIIFETFIIELEGLFASENYTSLEIVMYSSFKLKKFFLKYPVFYKQCKFLSIGSWGTFYDLFQVGVYLSADKFNGCLIVNESGKFDLIEAFLQFKSKCPNPAAFEVYISQLTLILESTEYSESEKYALIYELILEISVEFPDLKEEFLELEIGSFGSIYMLQEISVQYYRMKEVKKLFKGTPKCEFVSALYSCLSDSKYQLSMSNKGYLKVLFDKFSVIIANDTLTYAEQIKAISYQYRQFIKTYYYLQETILSFEISAEFGTFGDFIAMFAFGESQECWPEDFLTFPEVTTEVATTETATTEAPTTVPVTGDCSTASSVVLQVVGTQSILYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBQ3</accession>
    <name>A0A0N5CBQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBQ3"/>
    <dbReference type="STRING" id="174720.A0A0N5CBQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001531700.1">
        <property type="protein sequence ID" value="SPAL_0001531700.1"/>
        <property type="gene ID" value="SPAL_0001531700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001531700.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62225" checksum="7C0863A4105A0FA8" modified="2015-12-09" version="1">MSLLSNENSQIYEEELFEKVCASVSLEEQNESEKTLKNLLTNNILKMKDSQGRSLLMLSCMADKPKIANMLLKKGLRFDEKDINDRTSLHWAVKCESIKIVKWLLQLPINENFILSKDNQGVTSLHIAATKSSSKILRLLLSVLPKNEDLLSKIFDSQNRIPLHYAAATGSLECVEEFMDESLNLPVSIRDIYGNTPLMLACGNNYASEVIRCLSNKKSVSVTSRNGHGMSPLHIAVLANNINGVKILLEECKISTEIYDEDARTPLHYAAQNGRVEIVELLLEHGARYNAVDAYRATPAHYAAEISWPILRSLFIKSGHSDMIDKEGRTPFMWGVVSGNEETVLNMLRNFNIPRNGKDNQKSTALHLAALTGNSSMCKMLIQQGWLPTAEDEVGATPLHIAAGKGFTYLVDIFSTSDDIVRKVDIAQRTPLFYATLGGQAHTLNVMISDLGYDVNVHDIHGRSLLHAAAYGGFVACVQKLIEHGVDVNSKDKDEETPLHVACSRGKEEIVYILENAGADINAYSSITNATPLSYAISNKHTKIIEYLKERGATSVEEYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBR5</accession>
    <name>A0A0N5CBR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBR5"/>
    <dbReference type="WBParaSite" id="SPAL_0001532900.1">
        <property type="protein sequence ID" value="SPAL_0001532900.1"/>
        <property type="gene ID" value="SPAL_0001532900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001532900.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16801" checksum="30F8896DB0CB5668" modified="2015-12-09" version="1">MSNNIEDWFIPETSENPTFKNILDKSGKKTNNVTQRKALPEDIQKTLPDIPNFDFDAPIVVRLKKRNNNELPPNVKAAPKILKRKLDSGVKEIKNIKEQVKRVHFEIDRYRIGMTKDPAERLKANIDLAIKLGAKKPKGKPKSPKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCW1</accession>
    <name>A0A0N5CCW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CCW1"/>
    <dbReference type="WBParaSite" id="SPAL_0001571100.1">
        <property type="protein sequence ID" value="SPAL_0001571100.1"/>
        <property type="gene ID" value="SPAL_0001571100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF7">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="243"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="371"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="466"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="572"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="678"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001571100.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="161164" checksum="74478B61F97D86EB" modified="2015-12-09" version="1">MVFERHSCPEGNLFVDNLGCIDPTKDTFRYGVSTTGSGKVGDSCQFNTDCLSGMYCSMGTCACLSTYILKESYCYEIINPNSAGCIYDAQCQAVFPSAHCNMESGIGTCRCPEKTHLARETRDGWVCISLIDNASKNGDPNENLHFICPLPEGAGFKVALFDPNVKFDGLPVGCTVGSTSTVEPIPQLQGGAGCIWPSTGEYIGDIYDCIHTSPLINLKSKYSFSSYHPSANGVCCPSRALTCTQPAVSGPNPTEARWWFNSITGQCQQFLWDPTAPAAGDHSPNNFKTMEHCQNYCRDTCVRSYPQYTKAKSILKERPITSCSTTTSCGNEYQCKSIGSEHLCCPTIASICSYKGGRMIDSLAPRKTLYDPGFLSKTGKEHIRFYYNNEKKRCQSFLYKGAGGNFNNFISKHECDMFCSKLICEIGNPLKIGDDAQKCESNHDCPSSYSCNMVQKVCCPKKQTICSQPLRTGDCSENLQRYYYNPLIKQCVIFSYSGCQGNDNNFDTLLQCQETCKNISPEPRCPQGQAYKDSYGNFVNCNEGSTTTLVPNYFCFNDGQTSGLCPTKSYTCSLNSDKGVQCGAGTSFKYYFNPNKNSCEAFQYLGCDGNSNNFQTLEACEEYCGISCPNGGQPLRDHQHQLISCSDNESCPATHECTELSIKGSVSSRCCPTRGHICSQPPQTGTSCISNPITRYYFNIVTSQCSKFLYNGCNGNLNNFLSESQCNNFCKSSSCGAGESVFLDPNTNIPLTCNENLKNACPQNYVCTLNSFTNTHVCCGATDMGVCPHGEKAYINPMDMTAKECTINQEGSCPSNYLCHFNLNKKKYYCCSGPETCPAGKFLYKNSKTLQPIKCNINGNSNQCPKGYSCQSYLKNSFQGFCCSVNDICPNNGEFLIDPTSNQPRLCTMGSYIGCPNNYYCQKNGNENSGYCCKGAPTLKSNGCPPGEYAQISGGEIKTCDPFNVHDFPCGEGYICQWSISNMGYQCCSGQKPTEYKREDGCPRNQKAFYEDNKIRTCTAGGSDCPLGYFCEFSFKNVQFQCCATSGGCPGNSVAFIGIDGEPEKCVLGQSQCKRGYSCQRTESNSFHCCTTGIVEEECKEDEIMYEGKCLKMVIVGDRCENNIQCLGGGICLGGSCVCPKRTTLIDGTCQPIPECLENQVLIDKVCYDKMDIEGSCVSHIQCPKTSFCIQKICSCRRNEHYNYDKGKCVKETSPVVVPSKKKVKKVKFRRMKPKLSLPTIDYQSIKTNVISTLDLYMNECYNRTLRPFIDPKTDKSQYCSPKTNTCPLGYTCEMNLSRQVFICCGKKNINEELNNLSNEDKVCPKGRVPYLLNGVPQKCTKTRCYNGYQCVYTSYEYYCCSESILESDIPIQNSISMLSEICPRGTPLIYPLTNTPIQCTPTKGNCPIGYTCDKSISQIYSYICCSLRLKKDYISNITTFQQIENVVDNLTGYDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE69</accession>
    <name>A0A0N5CE69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE69"/>
    <dbReference type="STRING" id="174720.A0A0N5CE69"/>
    <dbReference type="WBParaSite" id="SPAL_0001616000.1">
        <property type="protein sequence ID" value="SPAL_0001616000.1"/>
        <property type="gene ID" value="SPAL_0001616000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001616000.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15166" checksum="0C96B2BF144E3BF1" modified="2015-12-09" version="1">MSNKIYYTIFSDCSIKINGVEIGVHKRTLATRSPVFFELLYNKSEETQNNIVEINDFSIEVVDAMLSYLYRDEVPNIENIASEVLAIAEKYELNGLKGLSENILCSSLAIENVCQRFALSERFGTKILKERCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEH2</accession>
    <name>A0A0N5CEH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEH2"/>
    <dbReference type="STRING" id="174720.A0A0N5CEH2"/>
    <dbReference type="WBParaSite" id="SPAL_0001626000.1">
        <property type="protein sequence ID" value="SPAL_0001626000.1"/>
        <property type="gene ID" value="SPAL_0001626000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001626000.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35397" checksum="02E649F8DB1286E6" modified="2015-12-09" version="1">MSSLDSRIVTGLQNRFKKHDKNMWIFTEEELANVPSIKDGMSAQDVLECRIRTANYITQMMIMLNKKATGVKRITQLCTCIAITHMHRFYTLHSFKHFNMIDVAASCLYLACKTEDCYRKISYVIHAWWKLKFPGEHPPDDKDNLFIQSKELIELIENLLLKSVNFDMQLLIPHYVVLRVCQSCKVDRNVISAAYFYVMDMIHLTDWAVRYSDDTLACLGCHLAISHAIGNGDERLKSTIMEVDPCEYIIKNSNNTISKSLISTLANKFLLFLEDNKDKMTFRRHLRFREKRDTGSHTKNQAIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEJ3</accession>
    <name>A0A0N5CEJ3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5CEJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001628100.1">
        <property type="protein sequence ID" value="SPAL_0001628100.1"/>
        <property type="gene ID" value="SPAL_0001628100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001628100.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44246" checksum="B766816164D67572" modified="2015-12-09" version="1">MPPKKNAVEEKVVLLGRVGTNLKMGILGLPNVGKSTFFNVLTKSEAQAENYPFCTIDPNESRVAINDERFDWLVDFYKPASKVPAFLNVTDIAGLVKGASEGQGLGNAFLSHVSACEALFHVCRAFEDEDVTHVEGDVNPIRDLEIINNELRLKDLHFLEPSLKKVEALAIRANDKTKKVEYDTLLRVKEVLESGKPVRSATWNEKEIEVLNKYLFLTAKPIVYLVNLTENDYIRKKNKWLAKIKAFVDETDPGATIIPFSGAFELKNIEMNPDEREAWYKEIGATSNLDKIVKTGYKALQLEYFFTAGKDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMKVSDLMELKSEAAVKAAGKYRQQGKTYVVEDGDIILFKFNAGAGLTAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFE2</accession>
    <name>A0A0N5CFE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFE2"/>
    <dbReference type="WBParaSite" id="SPAL_0001657800.1">
        <property type="protein sequence ID" value="SPAL_0001657800.1"/>
        <property type="gene ID" value="SPAL_0001657800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001657800.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8658" checksum="005AB8409A0E8761" modified="2015-12-09" version="1">MGTEICNKDFNTDHIKRNSISSAPTTPNLHSPPAFVLDPANLIYLVPNPVNSKLADVLKPMTKCYRSTARKEKQFTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFK5</accession>
    <name>A0A0N5CFK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFK5"/>
    <dbReference type="WBParaSite" id="SPAL_0001664125.1">
        <property type="protein sequence ID" value="SPAL_0001664125.1"/>
        <property type="gene ID" value="SPAL_0001664125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001664125.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8485" checksum="C1BBA7F22E72E228" modified="2015-12-09" version="1">MIIEARRIYPTYSVGITGELRCRYKNTKNAFVEISNDPRPIIERNPIAMKVTKFKEAFFLAAFIRSFRRPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGQ2</accession>
    <name>A0A0N5CGQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein BIG GRAIN 1-like B</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001702800.1">
        <property type="protein sequence ID" value="SPAL_0001702800.1"/>
        <property type="gene ID" value="SPAL_0001702800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001702800.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42659" checksum="563B965CCF7864DF" modified="2015-12-09" version="1">MLHVFDHPRRPVSASPIIPPEKPKRYYMSLSWSLNDISVKEKRLVEFFSKNDDINKKKMLNDKILEAKSTIEDDFDNILIEPNKFQNMSATTKRSIWRGIPFYGSDSTTSHSGSTCRTTTDSSMCSCSTSPYSSISLHHKHSFFSIKNPFSQIRRNKNLQRSKQLINAYSDASYKSVNSLNSIYHDDVTLRSRDFSLPEKDTATRKRSKSKGIESKILCPLKNSARKISNALHLRPLKKSYENISQGSSPLPLQTSVPPNNYTNSSFLDVDFNIDELNYYSHPSSPNPSPNLYHQGSKNLDAPKMTKSENQKKVFEYSEGSPYSEEFIKKELKKNLEKHKSVVRRKSCDPILDSKPFDNYLNNDFRERMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH35</accession>
    <name>A0A0N5CH35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH35"/>
    <dbReference type="STRING" id="174720.A0A0N5CH35"/>
    <dbReference type="WBParaSite" id="SPAL_0001715800.1">
        <property type="protein sequence ID" value="SPAL_0001715800.1"/>
        <property type="gene ID" value="SPAL_0001715800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001715800.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23881" checksum="E158140B501DF0AC" modified="2015-12-09" version="1">MTRKRRKTFLLVESNGLLINDKLTILCEVEIIDLKFENHYNPETSINPTIPQSKLLLDYDDVFDSLLFTDCIIGVKDTEIKLHKAVLAARSSAFYNTFNSTLEKSKTNIIEIKDFSVEVVREMLKYIYKDEVSNIQNMANGMFKIANKYELHRLKAISEQSMCRSLTIENVCERFTPSETYSIETWKECCQDPILVNGAWLTKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI37</accession>
    <name>A0A0N5CI37_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI37"/>
    <dbReference type="STRING" id="174720.A0A0N5CI37"/>
    <dbReference type="WBParaSite" id="SPAL_0001749800.1">
        <property type="protein sequence ID" value="SPAL_0001749800.1"/>
        <property type="gene ID" value="SPAL_0001749800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001749800.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46279" checksum="8BE01F493ABC8E6E" modified="2015-12-09" version="1">MNKYIFIGNSINLIVFLILSVVLHTLTNIDDKKNLVMVQVVWRHGDRVPTSSYPNDIYKDEDWEVPYGTLTKSGIRNQEKLGKNLRKIYIESSGFISDKYDPDEVLVRSTKKNRTIESAYANLRGFYNIKSSQNIPILTDFFGIDDEWNKGKSCPRLQKVTKDAISLIESEVLVENKELIDTLKEKTGYTKMNLRDISTLYDILHVQKLIKGFLPEWTENGVYEKLQKLTQEIYRLYGGASAFGRPENPDIMKLYEGPLLKIMIQYFDKKEEQLKKDIINPKFRLLSGGITLPDKLKYIAYSAHDYTLDQLFFLMDLDDNLVTEELSSDFTATLFYELYKYDDIYEIKILFSRSGAENIIDITDRVIGCKESKKCLYSDFKNGIKDRIPSDIKSECGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2U0</accession>
    <name>A0A0N5B2U0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2U0"/>
    <dbReference type="STRING" id="174720.A0A0N5B2U0"/>
    <dbReference type="WBParaSite" id="SPAL_0000039300.1">
        <property type="protein sequence ID" value="SPAL_0000039300.1"/>
        <property type="gene ID" value="SPAL_0000039300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000039300.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25773" checksum="DA80110AC2576DDC" modified="2015-12-09" version="1">MTSNVTLYTTNQEGKSKEYILSTADRFTNVSYTNITLSVRQNLLQFIKEKLKPTPSDGKSTSKEFATLKAGTIVYKKIVNAHKNNEQFHGPYRILEHLHGNTYLIGTLTRSNRKKGQIERCNARFLKLALLAIQNTLNKEAHSLDNDNIQNTQVTSNFPQTSINKKGRDKPRKVLSTNNETPNTDEIIIQPKKGRGRPKKIISINNNSNDSLDNQQPKRGRGRPKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4J9</accession>
    <name>A0A0N5B4J9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4J9"/>
    <dbReference type="WBParaSite" id="SPAL_0000100000.1">
        <property type="protein sequence ID" value="SPAL_0000100000.1"/>
        <property type="gene ID" value="SPAL_0000100000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893732" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000100000.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15402" checksum="C120B9C163C96E7B" modified="2015-12-09" version="1">MVKIYSIFLFLILFLNTFICSLFENEVIVRGIAVCYERDFRGPSYIKISLLDKEIFRDYYMGTEIYYFLDYPDIDFTISGSADELSPLDPYIIYECYCGNHIKVREVRLYEHGVNRRNSIYYIKIDCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B555</accession>
    <name>A0A0N5B555_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B555"/>
    <dbReference type="WBParaSite" id="SPAL_0000120200.1">
        <property type="protein sequence ID" value="SPAL_0000120200.1"/>
        <property type="gene ID" value="SPAL_0000120200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000120200.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="74218" checksum="4AA9701205F1C063" modified="2015-12-09" version="1">MNYNTHGNESSKYINPNQLYPLPYTTNYSQLVRSPILKNQGRSLSAREYQIDKSFDSFSPKIHGNSKSFESAETEDYDYILRKSSEIMNSNKTTKCFKKHSFRRDISPYRTHKKQTLSVSYLPNVGNISPRILPNSPKQFSSNYDIKRPSELGLFQYDDIEKSGSNSDNRQSFLWNRNLLYPTTSFKIMRSTSCRSTPNQTKFIPPTNDEYKNYDGPQYSSSNDLNIIDFLYNVRSFDEEKNSYDSENIVQKSSSNLFFKRATRSVEKKMAQLKMGQKESRLQKSTNSLCPGFSNSFDNSYIDTNKKTEKTKNHINNSSRTNSTNSDDSYPIDNKSSTKAGSSGSLNIFTKNKHKKSDCRVQNGIRSSSATSKSASSKRNVSPPKLIAVKKLAPISSSSQEIIRYCMENVRGDIASRIVSRMAHKREDFAMFITNLSADQLNEFTGALRDYMNQVLKHVHSTDKIREVSMQFGILQVSRREWGFKADFFACMANSITTECVFLDGAAHQPTEAIEAWAELVELMFTNIREGYYQQIRYLRRRSQCFSGYFSQSQDASTYNENTSDGLNYLDSANDKTSTNDINRRTLSKNSREENYRHPWAMQRQMSESGCYGERPKNPRTRYNYNASKNSPIEPVMSPGVIINIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5L6</accession>
    <name>A0A0N5B5L6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5L6"/>
    <dbReference type="STRING" id="174720.A0A0N5B5L6"/>
    <dbReference type="WBParaSite" id="SPAL_0000136000.1">
        <property type="protein sequence ID" value="SPAL_0000136000.1"/>
        <property type="gene ID" value="SPAL_0000136000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000136000.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16999" checksum="B5371BAE7911FF7D" modified="2015-12-09" version="1">YLNPRETMTVDRCCKKEEKIRKKLSVLKPALVNKRGPILLHDNVKSHVSKTTVQKLKELECETLPYPPYSPDLFPTDYHLFKRLELNLRQKKFTKSYDLKNDVYEFLNFRDRSFFQMAYINSYHIGNNVLIPTVLISNKNINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5P9</accession>
    <name>A0A0N5B5P9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Small nuclear RNA-activating complex polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5P9"/>
    <dbReference type="STRING" id="174720.A0A0N5B5P9"/>
    <dbReference type="WBParaSite" id="SPAL_0000139500.1">
        <property type="protein sequence ID" value="SPAL_0000139500.1"/>
        <property type="gene ID" value="SPAL_0000139500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000139500.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="67763" checksum="18E8B5FE7C682B98" modified="2015-12-09" version="1">MSFDRNYVPSNPGAFSLPIVASEFLEHALQQRTILKNFLEKGEDIKPKNLIYNKIKKKLRPPHDNYVTENYFIDKLFDKNHLLEIKKHPRTFINGIKNLPIQSSSSSESDIEALIEYRMKNNRRFAMKGLDAVTKLFHRDNTDDELPSVAKRKCHKLISSHIEQVMNERTLTSFLRWKEKWCLNVLLCQEMTYQDFVDENESEKKMFRVWEKGAEILSSRMDTSNMNISFIQFVELLGGDKKSAKIAVKGVEGATDDYFDKNPKHKIVNREFTDDDRIFNKRCVDQFLKMKALLSTPMNMSEHKKKLKYYNFHEDFLRRTYPKINDDLPEDFVVTVSFFKPMMNKWKRPNYPKRIVHFAEEKKYQFRGDNTLLDLRDTILCSWDLVNTKPASNEFLQPEECFGTLIPSSFLFIHDTFYIDLCRPNAKNLAAEYKNFFDKKPHLFVEELKIKSMVEVKLKDLTFRLNTPYVYVHMGGNCEHTFNFNDMRLITSNDYQKLETYPIIRFDLMKIRRCNYCKKPPPCFIILEDNISPKLPALCCQFCFDYLFADKEGIKKENVIAYHYVDKLHHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5T2</accession>
    <name>A0A0N5B5T2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="STRING" id="174720.A0A0N5B5T2"/>
    <dbReference type="WBParaSite" id="SPAL_0000142700.1">
        <property type="protein sequence ID" value="SPAL_0000142700.1"/>
        <property type="gene ID" value="SPAL_0000142700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="11">
        <location>
            <begin position="70"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000142700.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34829" checksum="961CAD355EF8BA79" modified="2015-12-09" version="1">XLLLTPKDDYLKNRTRKNVSDLPLALSSPAPYSDEEAAILEREKVDYSKKITLEMAINNTAGRPIRVFSDGIYDLFHNGHANQLRQCKKAFPNVYLIVGVCGDEETHRLKGKTVINEEERYEVIRHCRYVDEVYRNCPYYVTLDFLKEMKIDFIALDAIPYAAPGEEDLYEKFRKVDMYIETQRTEGVTSSYVVCRIIRDYDKYVRRNLTRGYSAKELNVGFVAATKYQIQNSVDQIKQKSVEILNTWKNRSDEFIKGFISTFHPDGGLHYFTDKIRDLVSRSPSPTFEETESVYSDDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5X1</accession>
    <name>A0A0N5B5X1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5X1"/>
    <dbReference type="WBParaSite" id="SPAL_0000146300.1">
        <property type="protein sequence ID" value="SPAL_0000146300.1"/>
        <property type="gene ID" value="SPAL_0000146300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000146300.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11068" checksum="8ECA259A3FEBF85F" modified="2015-12-09" version="1">MAGKERPSGAQYRKRKAENDKLVAELSGSFLKYLSSSNTNEEKCVQNSEISAAVANSTTTEADIHIEGSEEGKKTDNEVTVCDKDNLENEPPYRSREEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Z3</accession>
    <name>A0A0N5B5Z3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Z3"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0000148400.1">
        <property type="protein sequence ID" value="SPAL_0000148400.1"/>
        <property type="gene ID" value="SPAL_0000148400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="538"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000148400.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="72622" checksum="A7ED491DFEB904BA" modified="2015-12-09" version="1">MTSETTNPKSTSTVQGNGIVEKSDSEKGKMSFAKVLLSGDNNSSKGTIVYSSTSKNTKPTTDIDSSSITNGNSNKGNRNNKKRNNRRSGNRVKNDLKTIVNDKLQESINEVKGKTPVNYESNNKNNGKVILSPAPMPVKNAWFSGNSEILRKNLILEKEAKSSVASESGVVSKSSAAPVCVIESDDKTKQFARVESEEDQSNQKEKKLKSNNKKGKDKKISEDCNSGEFGENVNKQVFVKDDKVDSTMITNINSPENSTNIPNNDTSEIQQPREKTRKKVFSKTIKKYHDSTNNGNQEDDGFDGDWKDSENTKDDTQYCYYDKGTDGYYYQNQGHQGWKKNGKNNVSSPPEKSNSPGLSTLPDQNNINGGGVVDDQSKDSGHNFNRRYKQYKGRRSGEHNSNDYDYRGNRQNNHYKERGPLPSWDEAAVHAEDGTEDGEDYMETLENQFRNMGPYYALPSFDPTKAAEATAAVVPVEPQLLLPIPNLPHQAVIFPQDLTTFNRFPNQPFITTAFPSLPHVPYHPYFQPHYRNPSFGSVMSTDQIKDCILRQIEYYLSEENLVKDFFIRRKMDENGYISLLLVAGFPKIKNLTHDINLVIEAMKTSTALEMSEDCQYIRTKTNPKSWPLLDEVKNTSEESKNVTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6W9</accession>
    <name>A0A0N5B6W9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal_L2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6W9"/>
    <dbReference type="STRING" id="174720.A0A0N5B6W9"/>
    <dbReference type="WBParaSite" id="SPAL_0000180600.1">
        <property type="protein sequence ID" value="SPAL_0000180600.1"/>
        <property type="gene ID" value="SPAL_0000180600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000428">
        <property type="entry name" value="Mitochondrial Ribosomal Protein, Large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF73">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000180600.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24737" checksum="F818E879C1EF495D" modified="2016-05-11" version="2">MCRLMDHKLMKNMMIQENMMVLFIKLLLVFSLKSVVLNPNTSKSLQIVCRRNYPARGTKPLPQHLWDEKHLKELTNGEYTHKPLRVNRLGGRDPETGKKINQHIGGGAKFDYFMIDFHRRGPTTPGDVYEERVLEVRRDPNRSPYIALVAGKEGKRWILATENMKAGQIITTSCYIPPNPIVGVEGCAYPLGALVPGSFINCVERFPNKESDVFVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B713</accession>
    <name>A0A0N5B713_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B713"/>
    <dbReference type="STRING" id="174720.A0A0N5B713"/>
    <dbReference type="WBParaSite" id="SPAL_0000184400.1">
        <property type="protein sequence ID" value="SPAL_0000184400.1"/>
        <property type="gene ID" value="SPAL_0000184400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000184400.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37579" checksum="53DCA33A510D1493" modified="2015-12-09" version="1">MTHFYLEQEISCLSINPKDSRQLIIGQLNGVFSMYEMKLRNLKPLGSLQLENESYVRDVSYMCDGKRFALTTSDCSLALMDTVTMEPYHWVNNATENKPSALLTLGGDKGIQTVVGDDEGQVKMFDFRTQEGAVLEFKEQDESITDLKFNQGSVFAASSDGILCVYDLRKKKVSVKSEQAESEYNSICISSDKTYIGTGNGVIDVYKNGEYGYILERIDAKMKYGIDSIVEVRENLLMCSSMLEDYVKFVNIQPNKVLKKKSVPFPIGKVIFDGNKKNFVGYGMCENFYHCSVAEMTNDIPLITRDNVRDTKNLVKDNDTNGFFSDLINDNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7L0</accession>
    <name>A0A0N5B7L0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GB1/RHD3-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7L0"/>
    <dbReference type="STRING" id="174720.A0A0N5B7L0"/>
    <dbReference type="WBParaSite" id="SPAL_0000203500.1">
        <property type="protein sequence ID" value="SPAL_0000203500.1"/>
        <property type="gene ID" value="SPAL_0000203500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000003">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="8">
        <location>
            <begin position="59"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000203500.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61053" checksum="702E10BFA8C0B370" modified="2015-12-09" version="1">MSFDFDLTAPFTPEFSTRDQIEHRHKIEAIQIVCPKEGGGFKLNENGLNSILKHNAIQNKKIVIVGIAGAFRKGKSFLLNFFLEYLYCLQKAQQNDVKLEWLTDETQVNGFHWKTGAKRDTVGIWMWGEPIMIEAINGEKYAVVLMDTQGTFDNASTYNQSTTIFALSTLLSSIQCYNLTENIPEDALQNLSLFVEYGRLALKESQYVGKPFQNLNFIVRDFKNPEEFSYGKEGGREFLQHVLEIHSDLEEELKDVRLQLQACFDEINCYLMPHPGHKVAERSSFRGHVKDIRPIFKEEVKKMVENLLNPHALKPKSVNGRELTCKKMIEFTKQFVKVFEGSDIPQPKNILNANCHLLCIESANEAKLAYCRGMNRATVDARMLSEKRLLEAHIKNGIVALNIFDKCPKIGSAQVRSEYLARLQEDINAELERYKKLNEDKRVTGLASIALAYGDSFFFGLGLAGCSTIAIGATYITLTAGVVAGGIVAIPITFTTLFAIWSYVFISEKIKDCKNQISQESEKKNERENEKVGKILKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7U7</accession>
    <name>A0A0N5B7U7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">APH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7U7"/>
    <dbReference type="STRING" id="174720.A0A0N5B7U7"/>
    <dbReference type="WBParaSite" id="SPAL_0000212200.1">
        <property type="protein sequence ID" value="SPAL_0000212200.1"/>
        <property type="gene ID" value="SPAL_0000212200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF35">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000212200.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35226" checksum="2D343B43D05A90B0" modified="2015-12-09" version="1">MVVKMRIVRITLVHSDIRLDNLIFHPTENKVIAILDWEMSTIGDPLADLATCAFAHYNSIQMTGGMNLKLPQKMREALPGLREECGFSINGIPNVDELLKMYDDSLISTDKSWLFYISFVCFRFAAICQGVYMRSKQGQASSPLAEGFASAPRLISSFALKFIKDDKEKVENNGKLGNFPTSIEGLSPRSRDMYEKIKSFVFDKVIPIEPELCKHSIGLWNLFITLNIDPTSKYGKGFTNVEYAHMCEVMGMSPFTPEVFNCSDPDTGNVEVLIKYGSEEQKKKWLLPLLEEEIKSCFAMIEPDVASSDATNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8R9</accession>
    <name>A0A0N5B8R9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid-sensing ion channel 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8R9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8R9"/>
    <dbReference type="WBParaSite" id="SPAL_0000244200.1">
        <property type="protein sequence ID" value="SPAL_0000244200.1"/>
        <property type="gene ID" value="SPAL_0000244200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF293">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="823"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244200.1"/>
        </source>
    </evidence>
    <sequence length="875" mass="101451" checksum="9553B4039F3A0469" modified="2015-12-09" version="1">MGTRVDNHFLPTTTMTTSKISDISTSTKLSFCERHYAKTTRNFIDQFADDTKMLGFRYLHSRYRTWFRVMWALFLFMALTLTIYQVVERISYYLFKNPLTTKRSFETLSSIPFPTIVLCNKMQLKASKVASYNPKLLSLMSEIFADDDDGIESDTDRRNISNIMNEIKSVVESNFLEIYQNSHQTVDDFIVNCQYGRKKQCIDNISIHLTPNGVCFAISPNITVTRPGPESTLSLLLNLETYDIIPGMVPDSGVILSIYDRNYSNTRLYDDGFHLEGGKLVTIPINDIRKLHRHPTECGKILLDIDGEYSKQACQWHEKSRRIEKTCDCIPSISPINKEVFSELNYKSIKNSLNSTREPCKLDEEYECVRVFVEDEDIKNDINNLCPEDCDDIRYNTIVFGNELDVGELSSLLPVNWEDEKERRIEKFFKAIELMPKKRIPIIKSIQKLATEAQVFISTINKILNNFKNLNIIKAVDIIDTPYCDSVLDPNVLSTLLREINSNERIWKHYIIYYNYVFKPNIVWLLKFFHLEDDDSLGSMNTTFGPDIIDKISVELNLLSKTINDPEKVFGLKSMTIHEKKLVSMHVENLITNTKACIENWKENDTEDSTTTTISLKCHDTFKKYLHPFEAGRNVAEVLSKANIAEDYFVIIKNLTNIIQKATGKNGAEIFNYKNYNIDIRKFRNDYRDDGKELGIIFELLKCRKILQSKIPKNIYDVVERIDSFIKDRDEFYMNVSMINNNIEIEYLNNSMECFSNFSTNIQSLKRYPFMRGDWMIRLQRDILTAQSYSSGQQFDKVNLLHVKLYFTHIKSESITNVRSYNLFLILAEIGGTIGLYVGATLLTVAETIVFLFENHVKTKFGVIKNKKSVRKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9B6</accession>
    <name>A0A0N5B9B6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9B6"/>
    <dbReference type="STRING" id="174720.A0A0N5B9B6"/>
    <dbReference type="WBParaSite" id="SPAL_0000263200.1">
        <property type="protein sequence ID" value="SPAL_0000263200.1"/>
        <property type="gene ID" value="SPAL_0000263200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000263200.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20777" checksum="D75DC06A7D1F7841" modified="2015-12-09" version="1">MAEGEQRNSEMMIEILRNIRDSISVIIHELNKVKKSLEASEKKYILHIKKVKNTNHKDCILNMVKILAVSRHFFEKIRMIKAILRSVSLESSSWIRRMSSNHTMRPSAIAIKKMQKKINIAQKHIPSINFLNVFSMMETKEEITSDKIDNIFEGFEDYEELESILEKFLVDLGIKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9L2</accession>
    <name>A0A0N5B9L2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9L2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9L2"/>
    <dbReference type="WBParaSite" id="SPAL_0000272800.1">
        <property type="protein sequence ID" value="SPAL_0000272800.1"/>
        <property type="gene ID" value="SPAL_0000272800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF65">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="369"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000272800.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="68457" checksum="28CA86EFAE99ED37" modified="2015-12-09" version="1">MTKTNDFYFDLKFFKSLIYLTPHFYSRTNYYSIVLTLLTLIISISSEVLGYYLGLVPGECYKALMTKNSKTFFAIFWKGSLMYIGKCCLLGALTASGWFLYIVYRSNITKSLHKSYFKNNVSLKVNLNYENDIDNPDQRITQDVDRMCNQLANSIMPAALICPFVIAYYTYKTYETAGFYGVGAIYLYFVVGTIVNRLLVSPLAKWTGRVERYEGDLRYKHVTIKNNCEQINFYRAQKFENESSDDFLFRLLKNHYYLSWWRFPNSFWQNFFNYYGGFLSYAIQYIPIFIFNSFEGLSPSELAQIISNNAFVYIYLVNSFTRLTDTAYVAGQMAGVLQRVSQLLQYMEESNDDELIIDNVNKFSGEYGLLMEDVVISKPHGGILVNNLSVNLEDNDSLLITGNSGVGKTSLLRVITNIWKQDSGKILSKYSIKDITVIPQKPYFPVGKLTLLQQLIFPKKLLDFDISITDIEGRIFDYLSMFKLEDLLERIGSLYTQPIFEYSDLTPGELQRLSIIRGLLTNPKILLLDESTSSISEDMEEILYKYLLKKSIIFISIGHRKTLKRWHNHILNICDDGSYIYSDNGTPKLNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9N3</accession>
    <name>A0A0N5B9N3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9N3"/>
    <dbReference type="WBParaSite" id="SPAL_0000274900.1">
        <property type="protein sequence ID" value="SPAL_0000274900.1"/>
        <property type="gene ID" value="SPAL_0000274900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000274900.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25097" checksum="A595F4D59AE07113" modified="2015-12-09" version="1">MMTSLWMFWKTLTAFTILFVCQTIFITYFWSNTWFVANNVKGYGPTTYTVSFGFNSYCIKSIYNTKPHCISLSDKGESFEDYGVQLSIEKELLTYLRVSKFIYILIIVSQLLMAIGIIGRCKYIDNNQISVSDVLFTSSSIVDVILKFALSNFLILGYNREIGATMYGNKIYSSFSMNMVLFVISLIMTVIVNILMLRSFVKTAEKCSCQRGKKYLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAU7</accession>
    <name>A0A0N5BAU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAU7"/>
    <dbReference type="STRING" id="174720.A0A0N5BAU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000316100.1">
        <property type="protein sequence ID" value="SPAL_0000316100.1"/>
        <property type="gene ID" value="SPAL_0000316100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF523">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000316100.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57058" checksum="02EAE40C31E9C388" modified="2015-12-09" version="1">MSNIESCSETSLTSGKKSNKEVVVNRNSIGILLAVGYIVGNVIGAGIFVAPTEVIRHTESSGLSMIIFSLAAVTSLFGALSYAEIGSMITESGADFAYLCKINWRIVAFIFMISGCLILYPSIVAIQLQTFSEYFLKCFNIQFIDSFHSKVCGRIIQIILLLIIILLNFQSLGKVVAKFNICASVCKIAAPAILILTGIYFIFTEENLPNYWDHSLETGNYKPLNLVVAFIAALFTFDGWDVLNFGAGELKNPKTNLPIAVIIGIALVSIIILSLNGAYYSVLDLDSILNTTTVASTFVSKTLYILEPIIPFIICIILIGSLNSSIFAASRFLQSAAEKKYLPKFISCKNGSSDSPRLALTLHAIFVVLALFSGNIEFLLKFSGIAQWCQRAVTVGALMWIRYKTPEHYNLKSTFKSPIIVPFIFFATCTATVLIVAYEEITSVLINFIIFILSGTIYLIFFDERLQKQKMLQNIKSYLHTFDKKLIVIAKIVFKCVPEEDNDVCMKNETYKMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBM4</accession>
    <name>A0A0N5BBM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting transducer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBM4"/>
    <dbReference type="STRING" id="174720.A0A0N5BBM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000343000.1">
        <property type="protein sequence ID" value="SPAL_0000343000.1"/>
        <property type="gene ID" value="SPAL_0000343000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000343000.1"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128213" checksum="11F0218C24C81DB3" modified="2015-12-09" version="1">MDNQENIGLNNKFNIPTIQTYNSETESDEEVEFYNYSMVRVPSDRTIANISSNLVKDILSDPGLGIWDKISNDLLSNDINNSSSYDNNMEFSDKLKDGAEKVVNATESVVDNVKSAAHESEKAIENLIDFNHSDEESNEKNTKKEKEGVVNIGFDKLGSIWDSAKKGIEKASENIGEGADSLINKTKDIGHSVVEKTTSAKEFVSEKASDAWESTKHNLEVTTEKSKELGHSAMETTISTGDHIVDKVSNIFGASKNTDNDGDKKVSDEIEHPVTNEDVSTKEVVSEKLSDIFNSTKHGLEAAVDKASTIAKSVGDEVYSKGEELSKMLSGENDLVEEEDKSGKAERATSEGATSSEEATDKKISNLLSSSTGESDENVGKNKETEESFTDKIIKAEESVENKLSGVVDSSKHIVEDVVNKGKEAVESALDKTSSIEKDISSKVADAVDFTKEKAKEFSKYSEDFTHSVMDKVTGEPSADKKSPEIEEKSVESNISTNLAEKINELVEDEPEKDNKTSESLIDKVTSFGEYVSEKTSDAIHSAKESFDEFADKVKKEEESIVDKSVSIGKSAAEKASDLAHSAKKSFDEFTDKVEKEEESIIDKTVSFGENVAEKASNLAHSVKESVGEFADKVKKEEESIVDKAASIGGTVVEKVSDLGHSAKESFDEFAGNVKKEEESVVDKTVSFGENVAEKASNLAHSVKESVGEFADKVKKEEESIVDKAASIGGNVVEKVSDLGHSAKESFDEFAGKVKKEEESIVDKAASIGGNIVEKVSDLGHSAKESFDEFAGKVKKEEESVVDKAASISENVVEKASDLGHSAKESFDEFAGKVKKEEESAVDKAASTGENVVNKVKEDAIKATKVIADNASNFLNAVVDNSVELKDNIVNKVNKDFDHIESSAKNIEENIVDKGNDIVENVTETIKDSGNEIIHETKKIGDGVSNVVDSINDKKDEVVDKISSVAETVTNEIHSAKDKAEEVKDNIKSEIEKKSDDINENIKDANDAVKETGSSIANKVDHVIEDSKKAVDEAKNNTAETINSILNSSSSGLSKVGDSFSDLTEKALQKSGEKVKEISEKAKEEAREAFKNAKDIIDNVGEAIEKKTTIEKVQVKDNKSTNDQVKETKTPEVEKVKSEVPHAQEHKAPKESSQSSESNSEGPSNGVAKRAPANRKFCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBP9</accession>
    <name>A0A0N5BBP9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAPIN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBP9"/>
    <dbReference type="STRING" id="174720.A0A0N5BBP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000345500.1">
        <property type="protein sequence ID" value="SPAL_0000345500.1"/>
        <property type="gene ID" value="SPAL_0000345500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017246">
        <property type="entry name" value="Snapin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305:SF2">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000345500.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11784" checksum="FC76B8C7C4FBE889" modified="2015-12-09" version="1">MDVIQPLIVKLDEQVKLTRKSQTDLSSKIQEVSSYLKEITDMLEKPFELESYARKLEENNARILNVQTTLMSIQERIGELQRNIQREAYQTKEACNLTTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCD0</accession>
    <name>A0A0N5BCD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCD0"/>
    <dbReference type="WBParaSite" id="SPAL_0000367900.1">
        <property type="protein sequence ID" value="SPAL_0000367900.1"/>
        <property type="gene ID" value="SPAL_0000367900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000367900.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17759" checksum="291CC143A2A4A644" modified="2015-12-09" version="1">MIGKCIGPKKVFERYLTYEEKMELKELVEDTFNGSNKDFVLFEVFEYLQRHLTATQWNDIWPEIEYYLSLNLPCSPYASILPPNYYKALLKAVRNAGKAGRSKKEVKRLVDDYLDRILMDPQFQEETAHRFDYLTKQQVLIPSSNVPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCE5</accession>
    <name>A0A0N5BCE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCE5"/>
    <dbReference type="STRING" id="174720.A0A0N5BCE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000369400.1">
        <property type="protein sequence ID" value="SPAL_0000369400.1"/>
        <property type="gene ID" value="SPAL_0000369400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894286" evidence="1">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000369400.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41595" checksum="9F6FB9B86ECF7DEC" modified="2015-12-09" version="1">MNTIVTIVFFIFIQSLVCEDDRLKIKPIDMRFYDEVNCGRNDYLNDFDSSFKQSDSSYGYNSMVISGIPWMARIVDHNKTTICNGILVTQLHVLTNFGCLKGIEELIKQQTEYNILYGHYQVRIGEQSSKDVCDSDSDGIFNCSNKVIIRYINALHLPHPVLDDDLKYGVIELNRPVTTIPHACIYQYQMDFLGLEEENKVENVISLMWGIDLKNNFDKFELNAYYYNETFDYKDKRFANTFGCKIREDYLMVIEGFKNGMWKNIIKGAPLLRKVKDNQFGVYGIGEDTCVKNFNKEIKHIQEIFFVTFKSAQYFIFHSLNEVNHDEEYVGNEFYDISKFYGKKYRYNILIIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD18</accession>
    <name>A0A0N5BD18_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 16">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="16">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="5 16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD18"/>
    <dbReference type="STRING" id="174720.A0A0N5BD18"/>
    <dbReference type="WBParaSite" id="SPAL_0000391000.1">
        <property type="protein sequence ID" value="SPAL_0000391000.1"/>
        <property type="gene ID" value="SPAL_0000391000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000002">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000006">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000155">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000173">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 16" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="18">
        <location>
            <begin position="424"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000391000.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61836" checksum="8764E9FDCA0DF09F" modified="2015-12-09" version="1">MSNDLQSLGQDNICQPLLTDYYQITMAYAYWKANCHEEPAVFDLFFRKNPFQGEYTVFAGLEDVIKFVQNFKFSQSDLNFLKKIMPQTTEAEFFDYLASLNCNSLKIKAIPEGSVTFPKIPLITVEGPLAVCQLLETSFLNLVNYASLVATNAARFRHVAGNNVELLEFGLRRAQGPNGGLSASKYCYIGGFDGTSNVLAAKLFGIPAKGTQAHSFICSFNSESDFKNRMLRSKDGSIELDILNLCKEKITFLYEIMSWSVDREEISQSELVAFCSYAVAFPDTFLALIDTYDVLRSGVINFLAVTLALSDLGYQTLGCRIDSGDLCYLSTELRSIFNKLKTFVPQYAHYIDNIKIVASNDIKEETIQSFNEQGHEINSFGVGTHLVTCQKQPALGCVYKLVAMGDVPKIKLSQEVAKISIPGKKNCYRIYGKSNYSILDLMTLENEEPPQPGKQILCRHPFEEGKRALVIPSKVEKLQEVYWDHGKITHYIPSLIEIKQNLMSSMKTIRKDHCRFINPTPYKVSVSEKLYEFLHEIWLQNAPVGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDN1</accession>
    <name>A0A0N5BDN1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDN1"/>
    <dbReference type="WBParaSite" id="SPAL_0000411400.2">
        <property type="protein sequence ID" value="SPAL_0000411400.2"/>
        <property type="gene ID" value="SPAL_0000411400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894115" evidence="1">
        <location>
            <begin position="20"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000411400.2"/>
        </source>
    </evidence>
    <sequence length="674" mass="78181" checksum="610CC21300E32CC7" modified="2015-12-09" version="1">MNFFCIFTILFSIATLSYGYLKYNCYLGDKKPCEILMTPEDNVFKKIFMPMLDALTQFSVQFGITGYENDPKTILGQVNEDLKEVNQTTIKQFVDKLGTQYKNPTYVELIADYDPFFLPDHLISSSQRGLSRLDPFTAISLDFTFGEYELNKTKTLATLNNIIKDEVDQKTLQEFSKKLNITLPKTNITILMVENPDKIEIPIDVSKGLTTSGVVKSTTDTKNSTASKFATTKYITNISTNTSLRPTKAKFISKLNITLSPSRLTFPSRTGIVISHGYIYLCNNNGPTKKSCMLTITAEEDAFKKVLMKYLDPIDVLTCEFGLHEFCNNQERLNQTNINLKNMVNQTVMEKVVTELGLIYENPTNITLVTKEAMDAITSKSMMNILTVDLMTYIIDNNENKDEELINDSKPIPMLKKSFPSNDKNEYQGSSKYKLGACLIGKNFSSLIIRIFCSLNKNEKSGYFIANCTNDNRYPSLHEMAKEYNIKDLNELFNDYHMLMIVRNPIDRLISGFMQLCYFRIYLKPDQDFCYGCDKNLTCFINKLQTDLWKVAKNEIIPDQFYDYHFYPQVWQCEYYKYKSNYTYIKYSTPDMESFYKTLINYLENAHVPNNQLDYLNKFMHSFQTIHTTATKNETINFRNTLYEDSILLRKVCKMFYYDFVEFDFDLPKECLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDP5</accession>
    <name>A0A0N5BDP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rop family plasmid primer RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000412800.1">
        <property type="protein sequence ID" value="SPAL_0000412800.1"/>
        <property type="gene ID" value="SPAL_0000412800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000412800.1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3678" checksum="82DF9965EFD0326F" modified="2015-12-09" version="1">XNPFTLEDFSLCITQFSVCKRERELLHRING</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDU7</accession>
    <name>A0A0N5BDU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BDU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000417500.1">
        <property type="protein sequence ID" value="SPAL_0000417500.1"/>
        <property type="gene ID" value="SPAL_0000417500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000417500.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34321" checksum="A28AEAE2AEBB2183" modified="2015-12-09" version="1">XADNERVWTEKENFLKLSFTGNPGLKNNLNVNSKAIDYLYMFLNDTILGTIVDMTNASANNFINNLNENLEKIEWNSLTISELKNFLGLILHMGNIVLPSTQDYWKSDDLYDFPVFRNTMSRLRFNTILRFLTFSNESDSDDRLGKVRYLSNHFNKIMEEQYYPSRELCIDESMMGFKGRLLFRQFIKNKKHKFGVKFYVLTEPNGLILKHRIYDGTKIDFDGSSSATESIVLDLMKNYLSKGHSLYMDNFYNSIKLSERLLELATYSTGTLRSNRKLNPREVVDAKLKKGEIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFK8</accession>
    <name>A0A0N5BFK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypotheticial protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000477400.1">
        <property type="protein sequence ID" value="SPAL_0000477400.1"/>
        <property type="gene ID" value="SPAL_0000477400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894287" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000477400.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9605" checksum="4A7C78624BD2D3C6" modified="2015-12-09" version="1">MIDIILQKYSILILTILSIINAQFLCKIHGDCQKMNGCVINDFGSYCANECTNNGIMNGGCYINEVCRRVNDSEQKEAYVCISTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGE7</accession>
    <name>A0A0N5BGE7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cullin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGE7"/>
    <dbReference type="WBParaSite" id="SPAL_0000505400.1">
        <property type="protein sequence ID" value="SPAL_0000505400.1"/>
        <property type="gene ID" value="SPAL_0000505400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000505400.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24704" checksum="A1D11F0F9F07E5A3" modified="2015-12-09" version="1">MLTAEQYGVVTAFGIVISTKLGPTGITKFIEVLKNETDQLTTNKLKNKVIVIVNEQISLFLKDYQIINALDNTYKLLYNGTNLEDVEASFADCLSKSFDEDQLEAVMIFGIKILTRLGLDGMDIFISKTLGVLRPIIFPYMDKIKDRMFEMKKKNDDVLEGINEGYSMTITFATPEVITRAFCEFMKIFTEDEWNAIYPDYDEFFLINNYIHKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGK3</accession>
    <name>A0A0N5BGK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGK3"/>
    <dbReference type="WBParaSite" id="SPAL_0000510600.1">
        <property type="protein sequence ID" value="SPAL_0000510600.1"/>
        <property type="gene ID" value="SPAL_0000510600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000510600.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="29021" checksum="EEB283E2FFD0514B" modified="2015-12-09" version="1">MTNKNGTIDVVMENVNGVIEKMECDDCPENDNNLDNKEVTLRDSRSYELLMNMTKNREYIFRELNNITLEDINKFKTFPEFIGQYKNIIQGIAFLKYDNLGYIHESVLDKEKYDNHEIRMRHELLVREKKILSEEIRMCDTMNNDAFKLYKTLVKELNLNEDEISYEIQCTPETFTVSELINILQKHLNERKGAANTLEINETYLSTLKSFYEGRLAANSEKKAINCQIKKLVRNYSKSLKVSSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHD2</accession>
    <name>A0A0N5BHD2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHD2"/>
    <dbReference type="WBParaSite" id="SPAL_0000537400.1">
        <property type="protein sequence ID" value="SPAL_0000537400.1"/>
        <property type="gene ID" value="SPAL_0000537400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12 14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013951205" description="Zinc metalloproteinase" evidence="12 14">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="169"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000537400.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40421" checksum="3372D24B882C6FC7" modified="2015-12-09" version="1">MHFIKELIILILVAFLIEGRRRSEIRDETRKSLSDRSKKNFDDTVGGLKRLNKLQRRLMGLKDRNETKDEDTEVVVELPMENEDLYQGDIILTEGQIDEIVDGMVEQAEEKKIDVSDIESRAKKSSRGKRSISSSLTNMWTSPIPYYVDTGVNATLVTAALKGIESETCIRFTKSATPITGKPGLRYFKGSGCWSYIGRIYTDAPQEVSIGQGCGSNAIIQHETAHALGVYHEQSRTDRYLYVSIKTENIIAGTESNFAGYVPGYVNEYGIPYDFGSVMHYGRFSFSKNGNQTIVAIDGKYDKTMGQRKKLSFNDVKLINFKYCNSTCPSTSISCKNGGYLDPNNCARCKCPLNFYGTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHU0</accession>
    <name>A0A0N5BHU0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHU0"/>
    <dbReference type="WBParaSite" id="SPAL_0000552500.1">
        <property type="protein sequence ID" value="SPAL_0000552500.1"/>
        <property type="gene ID" value="SPAL_0000552500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000552500.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41307" checksum="EFA0229B174652C5" modified="2015-12-09" version="1">MNDTNFIAESTEEKKDFVLPPLPDDVMVKIFSNLSLGDLLKVKECCKRFSHLIEKFYYKMKREKAFRVIIGYDKPFVRSYFSFSMYVVRSGSVGCSLHGYSKRSIDEDSELIRAIRMFKTDYICLFDIYGSDNSKIYQILSDCLKAGSGIGTITIDNFGKKALKTFYLFMNKLGYVKELKFKNVSLRDDKIDNPYNIMGLGNLKSLKKFALSESENTRFLNLDFFIQLLDNNPLLKNIDILTTNRTLIYDVIIKLAMDQYNHQHQEVEEVPLSHGGACNHESVRITFGGPRNIYLFAKMLYESVPFLRGTLIGDVSYYSNDTYSGFGIMKKCEVCLKLYRSIDILFIEFKNYHSVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI91</accession>
    <name>A0A0N5BI91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clr5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI91"/>
    <dbReference type="WBParaSite" id="SPAL_0000567500.1">
        <property type="protein sequence ID" value="SPAL_0000567500.1"/>
        <property type="gene ID" value="SPAL_0000567500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000567500.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27286" checksum="3D946378E747BE8F" modified="2015-12-09" version="1">MEDITLWRSDRLAIESLLVTLRTLKESESWSEEELERLAIQKFWVLQRYNLGSKRLIEECRKILKSVKRSSANSEKKVDSKKRKKRSNFSESMSASKINNIAPVTTTAPGTPIVTIAGSQHLPFVNTPIATGVGSHQIPLLGTPMVAGLGGYQTPYGMNNNKSSYVEKIPEEDWGDVLWLSLEDQIREEIEYLPESVKTNYISLKATLMEKFATHLEAKQSRMEADVYELNFADGEKLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIZ6</accession>
    <name>A0A0N5BIZ6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIZ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BIZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000592400.1">
        <property type="protein sequence ID" value="SPAL_0000592400.1"/>
        <property type="gene ID" value="SPAL_0000592400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000592400.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="54103" checksum="AC32BBC045F78521" modified="2015-12-09" version="1">MRTQRKSSQCYEDYGISCGVKESIKILGISRVVIFLLQLFSTLLLPEFPTDAFKNDFNINDNSFLSKAIFQLLKGYSRWDGQHFMNIAKNGYKWESTLAFQPLYPTIVSLFSRLVPFVSEDAGILLVGVIFSNICFIMTGILLHYIISHIFLINSYTRKIAIIIFAYNPSSIFFSSMYTESLYSFLTFLGIYYLYMEQQLYKSVIGTSIIFSLALLTRTNGILNIGYIGYKLLSLWMSEKVTTRRFAGLLILSFIILTLPLRIYEYLVQKNFCSQEPSSIMVSPSDDGKYIYPGDLENLSWCPVTGYYVPSLLLPSFYSAIQKKYWDVGLFSYWQFKKIPNFVMAGPTIFYTFYASKFVIMKTLNIKSYSTIILPIRSLLPFSIHSSFLALMAIFIYNVEVSTRILFSSNPFIPMSLAILFSTTYKQRWNNFPFDLVWNENLISLYFCYNLFLFAIGTIGHCIWLPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ99</accession>
    <name>A0A0N5BJ99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enkurin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ99"/>
    <dbReference type="WBParaSite" id="SPAL_0000602600.1">
        <property type="protein sequence ID" value="SPAL_0000602600.1"/>
        <property type="gene ID" value="SPAL_0000602600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000602600.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25537" checksum="1E409DE3405A073C" modified="2015-12-09" version="1">MSFNYRSSSLPTKQNTSLHVSGDAHASETKPVNIMLQPSQVVPIMLQARPPIHESGDHHVSEVFPNHDTTYASKATPSNKVVSFQEHPKLLPNVDTSLPAFKGWRNLFHKGSTSILSQVSHLRLPRQVDEMKPGQNGIPLAEQSTIMKTVIAELLNEQQQVLDTEPHKYDALRAEQTNRLTEVLKELHISSDYYVPDLRASYTPKKRSIRTVSELENALLLAQTKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJH9</accession>
    <name>A0A0N5BJH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000610500.1">
        <property type="protein sequence ID" value="SPAL_0000610500.1"/>
        <property type="gene ID" value="SPAL_0000610500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000610500.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11797" checksum="07C0F7F3C7D1C786" modified="2015-12-09" version="1">MADMIFRHDNHFQLEIILLQKVTKTILTNSKSLNQNIFLKVRIETVVLKSLHFKGRSDINIPSYHKRVFSLYIKIISLDSDDYLQCFDVQESRELEQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJS9</accession>
    <name>A0A0N5BJS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJS9"/>
    <dbReference type="STRING" id="174720.A0A0N5BJS9"/>
    <dbReference type="WBParaSite" id="SPAL_0000619800.1">
        <property type="protein sequence ID" value="SPAL_0000619800.1"/>
        <property type="gene ID" value="SPAL_0000619800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="115"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000619800.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31739" checksum="B687D42D20110894" modified="2015-12-09" version="1">MLKSEWKSKNKPKTPYVMIIALTRELVIQISEYGRKLCEGTKLCCTMLYGQKTKDFFKANLDSGCDILIATRGRLTEFLSEEKCTPQQTPLYTARQNLLFSATFPQEPQEFFREWVKNNAITIQNDKSNPVSKNIILTFIRVEGMHKNKVCADVIITENKEAKKHGMSLRKTLVFHFFLTYNGIKVLSINGDHYQDYREKALKEFRSGNIDVLVATDVVARGIDICDMEHVMIVELPGDFTTFIHRVGRIGRMNEGQVTTFYDPNKDYILADEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKU3</accession>
    <name>A0A0N5BKU3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">transketolase</fullName>
            <ecNumber evidence="9">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKU3"/>
    <dbReference type="STRING" id="174720.A0A0N5BKU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000654800.1">
        <property type="protein sequence ID" value="SPAL_0000654800.1"/>
        <property type="gene ID" value="SPAL_0000654800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="302"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000654800.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="64644" checksum="9CD0D8570D4972A1" modified="2015-12-09" version="1">MPANIGALKDVANRLRIASIEMTAVAKSGHPSSSTSAAEIVATLFFNEMKYEVASPKAPYSDRFVLSKGHACPILYAAWEEAGLLSHEQILSLRKIDSDIEGHPTPRLNFIDVATGSLGQGLSIAVGMAWVGKYKDKASYRVYALLGDGETAEGSIWEAAAFAITIVDVNRLGQSQETQLGHEVETYAARFKAFGHNAIIVDGHDIEALLNAFATARNTKDKPTAIIAKTFKGAGIEGVENLENWHGKPVPMEKIEAIKSKLSSTQKGSIPIPSPIKDTPEFDLNLGNIKIAPPSYKLGDKVATRAAYGTALAKLGDASPHVIGLDGDTKNSTFSDKLLAKYPERFIECFIAEQNLVGVGIGVGCRGRAIPFCSTFAAFFTRAADQLRMGAISFANLKCAGSHAGISIGEDGPSQMALEDLSLFRSVANSVVLYPTDAVSAERAAELAANIHGIVFIRTGRPALPVIYNNDEPFAIGKAKVVRKSDKDSILLVGAGVTLYECIKAADELASSGINACIIDIFSVKPIDQQTLINEAKRCGGKVITVEDHYQSGGLGEAVSSALADTSNVRVRSIFVRDIPRSGSPEGLLDLFGISAPHIVKAVKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKZ9</accession>
    <name>A0A0N5BKZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000660200.1">
        <property type="protein sequence ID" value="SPAL_0000660200.1"/>
        <property type="gene ID" value="SPAL_0000660200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000660200.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55623" checksum="293AED6BFCCFD71E" modified="2015-12-09" version="1">MENSSIDLYDINNMVDDSNNTLSGNTLTPPEGCFDLYHPIIIPRFYLVCVAGFITSIVSIIENSFLFFLFAKKKSNRNHYNLYLMLIAIIDVFMGISYILLMVVNVSADYFQSLILLRLWYFYVVPMITISHVAMTSSAMCILAATFERYCITVNSKYTDFVKENRIFIALGSLFIAIFNKGSMFFEFEIITNETCFGTMNEYAIIPTSLIDSSCYTIFRVWYRNIATVFLPFFALAYLNARIVRALAKQQRLDYCADLILANSKNHPDKEKSRRKILTRSATRTLVLVVITYLISNVVNVILTVGEYVNKLQLQTYYTDAYFILLDASSFLCVLASALRLPIYMTCQSQLREEVLNLLKHKLRKDNLIDESNNSSNSNNNVGVPLLTYKKDDLTISVRLDDNIKSTMDFKNDLLSNEEEKDEGEAPTMVGQGNENNLNVDGDNEDFQILWDINDPVECQRINLPYKNDFFQYIIFSGSQKESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL84</accession>
    <name>A0A0N5BL84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL84"/>
    <dbReference type="STRING" id="174720.A0A0N5BL84"/>
    <dbReference type="WBParaSite" id="SPAL_0000668500.1">
        <property type="protein sequence ID" value="SPAL_0000668500.1"/>
        <property type="gene ID" value="SPAL_0000668500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="777"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000668500.1"/>
        </source>
    </evidence>
    <sequence length="1078" mass="123618" checksum="CA4CE284F670609B" modified="2015-12-09" version="1">MGNQKNYLKFFDKCPENLSNVKTGNNIIRTKPYCVENIPEKIEELKNQELIAIEVQINDINVVALCDTGTNVVTVHPDLANHLGLKKDKLIHIGTIAGGKAEKMSNQPLTVSYNFKSTVIKETMIAAQPCSFSLYQLIIGNQVMKNLGLEIDVKNLSVSETVQPMPTSMIIQKGKEIFIEDEFVKIIKHNFPNAYAKFSGDVGPGKVYVEKMEFELRSPEPMKMYPIPENLKDEHTKLVKQMLELDIIEPSTSTKIHPTLLLQKPGTSEYRFLFDGRLYNQLMIKINCYPNDANKIFLELKDFNHISKIDLSNAFHQLSIHKDNREYFAFHSQLGTMQYKRLVMGGKNSTILFQLAMERTFKSIEKYIKIFVDDIIIVTPGSFEFHRDILFKFFSICNDLELKVSLPKCQFNAKYIKFLSYKVGPDGITPCDESVDKLIRRHVPTSKKELYNFLQSASYFRRCLPDFASKTADLFTLAAGKDGKIEFSKEHLAAFEQVKEDLISAPKLAFYNPSFKTFLTTDASNNAVGAYLSQVNPDTNEERPIAFWSAKLPPTVKDRCPTYTELYAIEHALRYFGYLVSNIELTIRSDHKCLGKIMSTNNRKYIELLHGIDKHFCRITYIPGRNNQVADLLSRLNEPKECNAITRASSDLKHQLITPLSMTENMTKLINSMNLIEAQQNDNDIIEALETGHVKNHPISKNAQGIVKINFGGTRLQQPLWIQKNVKNYNNHYGYKKMLKMLVNCYSPVLKKMIKEKLSSCDVCLKHNVVPTNHPIPSSIPPYQVMENLVMDFSGPHSEEGKNKEKYLLVIVDSASKYLWTIPMHTTTGEEIIKVLTKLFLEYGFCKTIKSDNAKYFNNEKMLTYLKSLNIEMVFTTPSHSRGNTLAEATIRYVHLAVGKAKSQFKSSIVSWTEILPWTTFIHNTNVCESTNTTPFSLMFLRESPNPVDMFMKSNNISLFESNRTHAEQLELARIARANANEFYQSYREEENLRLASKDDFKLKKDQLFYLKNIKRKKKFDAAYVGPYVAESFDPETNKVKYYKPTGKKLWECHISNVKIPKESLKLPKNPEIMLDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLZ0</accession>
    <name>A0A0N5BLZ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLZ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BLZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000693700.1">
        <property type="protein sequence ID" value="SPAL_0000693700.1"/>
        <property type="gene ID" value="SPAL_0000693700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033547">
        <property type="entry name" value="transpos_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000693700.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="36337" checksum="D768DEBB8B87637C" modified="2015-12-09" version="1">FLFVKNILLSKMALFQLYELVRDEEMSIKFLQEHELLPKTKECINGHEMKLVMGSPPRWRCYVRDCRKDIGIRNGTWFEGSRISFRTAILFIYCWTRELTSVDFCKEDLDMNHNTTVDWNNYLRKVCFFKEESSQTKIGGEGQTVEIDETLFVRRKNHCGRLIEQQWCFGGICRETREVFVEPVPDRSAKTLMEVLRRRVHEDTLIMSDMWKGYSRVEKNGYEHLQVNHKFNFVDPETGAHTQNIERVWRSVKERNKRQCGTRRSMLESYMFEFSWRKRNKENAFKQILADIKDFHEYHKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM93</accession>
    <name>A0A0N5BM93_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM93"/>
    <dbReference type="STRING" id="174720.A0A0N5BM93"/>
    <dbReference type="WBParaSite" id="SPAL_0000703300.2">
        <property type="protein sequence ID" value="SPAL_0000703300.2"/>
        <property type="gene ID" value="SPAL_0000703300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000703300.2"/>
        </source>
    </evidence>
    <sequence length="483" mass="56933" checksum="EB358AADA6EC5C8E" modified="2015-12-09" version="1">MTAENTSYGTLAIFRKRSTLFSCGYCKDNGKRNFSHGCLIQSLTYKVFESLLDRGWSSFLGLVAIELSPLGYNITMDRGWRRSGNYLYKPIMDKTCCPQYTIRLNLDKFILSKSHKKVFKNIKHFLQIGECKTRILNEENISLPIKKAKNNSETETKEESIDKSRRMSKKKNIRRERALEKLKSKGIDIEEYQKERQKKEDNRKKTLSNYIEEIKSIEGQHKLQFRLVYIGSDAFKETKKESYNVYKKYQEVIHKDPNNSEANWHDFLCCGNIFKGSGSSKTSNITYGAYHYHYILDGNIIAVSVLDILPHLISAKYFYYDPQYAFLNLGTFSALHEIYFAQTLHASDPKLKYYYMGFYIHNCPKMRYKANFRPSELLCDHSYQWMDLKEAVDMIEKNDGKFTIFYPDVDGIETIDLDRVRFINPRKEIHGYRSMSRQSGYEYLNDPYQREVIQYMMNRIGKACYNMKFFIIGERINYDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMF0</accession>
    <name>A0A0N5BMF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotrophin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMF0"/>
    <dbReference type="STRING" id="174720.A0A0N5BMF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000709000.3">
        <property type="protein sequence ID" value="SPAL_0000709000.3"/>
        <property type="gene ID" value="SPAL_0000709000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039260">
        <property type="entry name" value="Cpg-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37973">
        <property type="entry name" value="CHONDROITIN PROTEOGLYCAN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37973:SF1">
        <property type="entry name" value="DICKKOPF_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894530" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000709000.3"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113095" checksum="061D97837D8C2017" modified="2015-12-09" version="1">MQTGTRSRFALVLLFSLLIGLSFGANARRNGIGAAIVGGIVNTNKAIIGGITGTIGAVVDTAKESNNATEKEDKRASRSAYGWDDSSYTANKVDDNLFPQNLPSDDGNSMLTEMNGGDYGGAEIFQSDEQFLDVNVPSSTAETDVDVEGSGNLYEPVVVVNEEKSTFGEESSYSSAYGQGAELLPPSNANKLTYGSEMEGTVKEKKLPASGNKAVEFVAIYAVRRRRDSRRTKEVARNGKNRKSGSLNADAPVEQQRSRRDDDWDDHFDDNNSGERQRVRVTTNRLSPKQPSSHEDDNSGERQRVRVSTNRLNQKQRSRRDDDWDGHLDDDNSGERQRVRVPTNRLSPKQPSSHEDDNSGERQRVRVSANSLNQRQRSRRDDDWDDWFDDCDDADDIFDPECRARLNHPVQSQRNPVPVSPKQNSVVTNPMNQRGLPRRGDDWDDWMDDDCDDLDDLNDPECRMRLSRPVQQQRNPVPVSPRGNAVATNPLNQRDRPRRDDDWDDWMDDDCDDADDLFDPECRVRLNRQVQPKTNTVVLSPKEKSVAANALSQKDRPRRDDDWDDWMDDDCDDADDLFDPECRVRLNRQVQPKTNTVVVSTKEKSVATNTLSQNDRPRRNGDWDDCDDADDLFDPECRRRLNQRPASPLPPVRNPRPVPQQPPMRDPRPPVQSRPPMVTPRPVPPRPPMWGPGPVQPPMRDPRPPVQPRPPMVTPRPVQPRPPMWGPGPVQPPMRDPRPVPQQPPMGNQRPVPPRDGRAPAMVIREETRPVSPREGNVSATPMKDQRTVSPEEEQVSPAPAGGPQPFQPNNNQGHPRRSRRSVSEAVVGGVTETSKAVANGTEKVVDATTGGKKDKVKSKETKGTKKASKVGGITDTANSTATGVESTVDEAKKEVKTTTTTTSKPKETLSSSNSTCKSQNVCYGDSDCNGGRCVGAFVGTCNCNACFNFITCTSDEGCGGLKGACDMNTKRCNCQEAHRKLGYPNYFDALTKFCNHQSCDGSSNSCNGLPCTSGRCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP54</accession>
    <name>A0A0N5BP54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000768200.1">
        <property type="protein sequence ID" value="SPAL_0000768200.1"/>
        <property type="gene ID" value="SPAL_0000768200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000768200.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8816" checksum="B128F03294E52C03" modified="2015-12-09" version="1">XGIKIKIVVTLAHLPPGNPCFEKQALEIKHRKDKSLTGLCLCTYASNVTLESEDHEVLIQYNGKNKNHNAKIEYQAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSG6</accession>
    <name>A0A0N5BSG6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BSG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000880900.1">
        <property type="protein sequence ID" value="SPAL_0000880900.1"/>
        <property type="gene ID" value="SPAL_0000880900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="156"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000880900.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41304" checksum="E905440EAE00E282" modified="2015-12-09" version="1">MSFNYKGQKIVIDDILFDDTYSTFEERTNFNIPKDSKKKRILSKVSYITNDNLGGCSDWNCEIITEDNKNDVIDGVIVSSLTEISQYKSNIFVGLLTQESPAHDTTDSLANNVVYPHTFISFRHDSYTSSPYGYTVHLAPESQLLKNPITENDLINKSKSISWMVSHCQTPSNREGYVSDLKKYIDVDIYGACGNKNCTRENNCNYVDNEYYFYLAFENSICKDYITEKLWNRGYNRPIIPIVLKKSIVERYAPPNSFIAVDDFKNPKELASYLKDLIKDKNKYLSYFAWMKEYKVIFLDGQNHDIAERPWGFCQFCRMLHSNINKNYTRMSNYEKWWNNSCEKKGTLVDEHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSG9</accession>
    <name>A0A0N5BSG9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSG9"/>
    <dbReference type="WBParaSite" id="SPAL_0000881200.1">
        <property type="protein sequence ID" value="SPAL_0000881200.1"/>
        <property type="gene ID" value="SPAL_0000881200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000881200.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8378" checksum="2BCEFF551DFB0319" modified="2015-12-09" version="1">MFFIKHFYINKLFLLFKMNIIIITKLFTIILLSSFMISVSGEIFYRDWGGNIGSGNPALSSFFLLCGSINCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTW9</accession>
    <name>A0A0N5BTW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTW9"/>
    <dbReference type="WBParaSite" id="SPAL_0000929300.1">
        <property type="protein sequence ID" value="SPAL_0000929300.1"/>
        <property type="gene ID" value="SPAL_0000929300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000929300.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="74667" checksum="348FAC1E526BD69C" modified="2015-12-09" version="1">MEYSNDTIKCQLHYNDDYKEGKPFLEKHDTIIQSTNFKKKNEVWATRDRLLIIVIIQICIVFLWILHEAIRFDHSCSSQLSSSMSNSYPFTTDSGSLNRLSRSLIDETTKEPEIIALPNGTLLKVISRKRKIVVYKKPDDVDLENMPGEKNSRGILVGRKKIRVRVTTPSPNDSNDNNSTTTNDKKRRPIQRRYHLLTGANNKNLKNHYTSTKKESTSDGKVNTWLHGIVNPNDPQFTNKGEIRAVKVKVAKKKPKIDLEQVGMDGKYIQNYNIDHDMDIKNEKGNNFNVQSKSQDTGREVINDAISNNKNEGNNIKESGDNYDKGSLGIPFTFLLNSEKEINKFAKSGDEFKYTSDDIPPTEYHEGENINNKKNNILNENILTKQPPEKEEEEQRFEEVPPNILTPNPSMTYFDNKDYYTTDKEEKEIKEAFKDPITVDTLQKNTTSPNNFTTELSRFSYNTTCILRTLLAFWCLAQLSTLIFFLIGLILNYSTLRCLFIPHIISEALFTIIASIYCITITLFSTVLYFLVTSKEMDFEKLLKWLALSFVILFLVLLHAWILDKKIKYFKRNEYKDEVKSEVVEILHNDDPEMEKIVKSKKRTPNVVLSSGSSNCSNYDSNNGSLVKLYSHGDYGRRLHLLDRMSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU16</accession>
    <name>A0A0N5BU16_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barrier to autointegration factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU16"/>
    <dbReference type="STRING" id="174720.A0A0N5BU16"/>
    <dbReference type="WBParaSite" id="SPAL_0000934000.1">
        <property type="protein sequence ID" value="SPAL_0000934000.1"/>
        <property type="gene ID" value="SPAL_0000934000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000934000.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10070" checksum="503F80586A0F3C5E" modified="2015-12-09" version="1">MSTTKKFESFINEPMGEKHVIEVPGVGKKTAEKLGSDGIEKAYQLQGQYLLQGKNESEFNDMLQDKYRMNTKNAGQCTDSISQYTNRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVD6</accession>
    <name>A0A0N5BVD6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prolyl endopeptidase</fullName>
            <ecNumber evidence="3">3.4.21.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Post-proline cleaving enzyme</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVD6"/>
    <dbReference type="WBParaSite" id="SPAL_0000979900.1">
        <property type="protein sequence ID" value="SPAL_0000979900.1"/>
        <property type="gene ID" value="SPAL_0000979900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895204" description="Prolyl endopeptidase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="12">
        <location>
            <begin position="476"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="957"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000979900.1"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132713" checksum="4F0BD2A14B52AE36" modified="2015-12-09" version="1">MYLKFLIFYIIALVTFLPYLSTDAKKLKNKNEDETNDLAEIDNNNNDKALVKNEEKEESKGKRKDKHIVKQKGNTNIHIHIHHLPPHCGPVKPKPPRPGKTTTRRTKSPKPPSGGKTTPGGPTTTTRKTKSPKPPSGGKTTPGGPTTTRTKKPKPPSGGKTTPGGPTTTTRKTKSPKPPSGGKTTPGGPTTTTRRTKKPKPPSGGKTTPGGSTTTTGKTKSPKPPSGGKTTPGGPTTTTRKTKSPKPPSGGKTTPGGPTTTTRKTKSPKPPSGEKTTPGGPTTTTRRTKKPKPPSGGKTTPGGPTTTTRKTKSPKPPSGGKTTPGGPITTTGKTKSPKPPSGGKTTPGGPTTTTGKTKSPKPPSGGKTTPGGPTTTTRKTKRTKKPKTTPSGPTTTTGNGKPPVKPPAKPTPKPPSDKKTTTPRSTKRTKTPPRSTTPRRTECDDWRDYYYERYHSTIKINVTEYIQTDRCQEKCYNVIFGKEVYDYYRHLEILRNKKTVDFVKKLNKLSYKYLSSITIRNYIERKIISFSSYPKFSIFEKHGQFVYYKYRRSSENQDSIWRRDGYMGKGEIFLNISEIDNTGKTTIVQVSFSRDDKYMAYAISVSGSNLWTIKFKETDKKYSKIKDELKYVFSPFMGFAYETKGFFYSAFVDKKGKLVTSLVDAKEMYHALFYHRFGTKQENDILIDVVYDIPNVFVHGWVSHDERMLFVRYSLGNSDSQQGIKFLRLHKISESSIKKGIQLEPLFTKYDAHYSIVDSLFDEVILLTTKNAPNGRVVKINIGNAGQSEKYWKDIIRGDSKKFIKNVQAVGQNYLYINYMENVTNKAFIYDKRNGRMLTQLDFETSYHVEFSGSIFNSRFFIRVINQVVPQIIYTGNTLDLKRISKKRPYKLKVVESTEISGIEKKDYVIKTVYYQSFDKTMVPMFIFHRKNMKLDGQNPVLLESYGAFGISSFPTYSPSNLMFVTHFSGIYVIAGIRGGGEYGEEWHKAGAGKNKNNTFNDFIVAAEYLIKKNYTRPAKLAIRGGTNGGLLAAVVSRLRPDLFGSVIMGSPLLDMVRYNKLNFGLSWNGEYGNPDNKEDFEYLLRYSPYHNIKMPMRPVQWPCTLILTSLNDQNVHAAHTLKYTAELYHVLRKDGIKYQRNPVLVSVTEEEKQTTTVTKKQIIKTTVDEFSFVKETLNIKWKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVK8</accession>
    <name>A0A0N5BVK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000986400.1">
        <property type="protein sequence ID" value="SPAL_0000986400.1"/>
        <property type="gene ID" value="SPAL_0000986400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894923" evidence="3">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000986400.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33224" checksum="DC85195FB192FE68" modified="2015-12-09" version="1">MHLKVLIFVLLTNLYLQCKTIKLTFNQEEGYKVISYFHNLNRLNITCEAGQGFTLDDLKILYNNKYIPSRYISREKNSTTLVVKNFVPDKSESTFECILDNNITRKSKTLKIIFYKMCTINQCLNGGTCFVQGNVEFCQCPYEYHGTFCEKFVPDINFFGILYKNGMQLPATTVAAILLLVIILLCIFIFWYITTYTKWGVEKIHKFYLKRHKAVVIDTINVEVKDKKETILMDESNYDLAINDKTEDETPFIDDPVQNYDNLNPKVCQSMSQRKLHFFSKSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVT6</accession>
    <name>A0A0N5BVT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BVT6"/>
    <dbReference type="WBParaSite" id="SPAL_0000994200.1">
        <property type="protein sequence ID" value="SPAL_0000994200.1"/>
        <property type="gene ID" value="SPAL_0000994200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000994200.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11364" checksum="1EA0E5E4F47A1B51" modified="2015-12-09" version="1">MDLQMQDLLVYETETNTYMSYFVSGAGSRTDRSQKNKDKVPNDSIRFVYPDNLNIFGQLGFSRGAFIGIEIREHQAILKFYNGGGSELHKAYLYPREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWK4</accession>
    <name>A0A0N5BWK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWK4"/>
    <dbReference type="WBParaSite" id="SPAL_0001019900.1">
        <property type="protein sequence ID" value="SPAL_0001019900.1"/>
        <property type="gene ID" value="SPAL_0001019900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001019900.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29528" checksum="CFBABE6AF2E97ECF" modified="2015-12-09" version="1">MNIATASNRPLSIEDIIIANAKEIERLHFWNESTKVDKDNKNDTFQKSNNGNKEIGNLSQITGKELLIANANSDGTISFFEKNDDKSIQSFDNIKTDNKINEASAPSFNMKDKSNLNNETVSVKISENDKHNSLKIVDGSKNSNQDTKIKKEKFDFFIRSVNFKNTSNNKYNEMSFVEEEDKFSTLQPLIMNNINQIGKSNQDNKEIESQKFVDSNHTSSLQIMLFNQQNSGKTVYCFNVQHYSIFIIFVLSYFTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWP0</accession>
    <name>A0A0N5BWP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NifU_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWP0"/>
    <dbReference type="STRING" id="174720.A0A0N5BWP0"/>
    <dbReference type="WBParaSite" id="SPAL_0001023100.1">
        <property type="protein sequence ID" value="SPAL_0001023100.1"/>
        <property type="gene ID" value="SPAL_0001023100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000001">
        <property type="entry name" value="Iron-sulfur cluster assembly scaffold protein IscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001023100.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16825" checksum="D7314CA1DA0640D0" modified="2015-12-09" version="1">MNTCTKFLTSISKNSCQISKVTQVASYHQKVIDHYENPRNVGSLDTKDPNVGTGIVGAPACGDVMKLQIKVDDNGKIVEAKFKTFGCGSAIASSSLATEWIQGKTTEYASKIKNDDIAKELSLPPVKLHCSMLAQDAIQAALNDYKKKQQMKNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX15</accession>
    <name>A0A0N5BX15_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX15"/>
    <dbReference type="WBParaSite" id="SPAL_0001035200.1">
        <property type="protein sequence ID" value="SPAL_0001035200.1"/>
        <property type="gene ID" value="SPAL_0001035200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895063" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001035200.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17459" checksum="36A92A193DBE6673" modified="2015-12-09" version="1">MKYLIFFLFTLLLNLSLCDKTGLTNIPSFLKIIPSNKRTEVEGIVLNQTLSQNEMYQKLDEWANTLGQAFNTLYTSYKNAFLEAKKELKEKHNLMLQSETDEDFKRVDAQIQSIADNYDMPIGEVRQEILQIINNQTDAIKEKLKEKSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXI9</accession>
    <name>A0A0N5BXI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BXI9"/>
    <dbReference type="WBParaSite" id="SPAL_0001051600.1">
        <property type="protein sequence ID" value="SPAL_0001051600.1"/>
        <property type="gene ID" value="SPAL_0001051600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001051600.1"/>
        </source>
    </evidence>
    <sequence length="791" mass="90093" checksum="93FF9C79BAC00BC5" modified="2015-12-09" version="1">MAFKDLRFSKNQLDSAGTFYELMLLILKNKGMTDSNKDATIESECKTELLSKLDLEVLKEIREDIQKSLEDSTTKEIMTSFKKLYMREDPDALRIINLFKNLNEKTSDLEFLKRETKMLEGLLSNLNGKQVAGLYALLKWDAPCGAEAAILSRIVSSEKVSTGDEMIHMIQSITAMTVTANITKSTTVGKVYNNVATKKSFRKKNDIRCFLCGKMGHIKSHCPEYTIQRKVKLITEREVMDREESDDDLSSIGMIDQVGKVSNGKRRLLIDIEIDGRKMKAEADTGSPVSFVSKANFDNNCIQPTKRRFCGLGGNEIKIYGKANVMLKINDKLFNAIVYIADIDHGIIGLEELKSAGLINSLLQLVSIINEPEKDEKAINKFVERFPKLFSPGLGCYTGQPVRLKWKRESECTYKHIPCRPLTSEILEPIVLDKIDKKRSEKAFKPLTKIEKECYDKCIEAATNAIKLTPVGETTTFTVQSDASSIGAGRILKNERGEILAVYSETFSKSEKRYPITHRKALAAILSIEHWSHYLRLRKFTLETDHSALLQIFQQDNYSRKAKSSRLVKFGLRLMSFDFTVKYIPGKNIRPADCLSRLLLEFKQEHGEEIIAKVVAPNELFLDLNSIKECMVNDEEAKELLNSIPNKDLPDIRMEDLVLKVGDTTHVPKVLRKKVMEILHYTHAGSSKMKSWGRKYFYWKSGVVDESVGKMVKIRRGQVQYLFHIDNVKKCNVNMDGLSLDSVMPKEKPIDVNKCKNKRKLVDDHVEAPIRKFRVTKQRTXXXXXXXDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY56</accession>
    <name>A0A0N5BY56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zonadhesin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY56"/>
    <dbReference type="STRING" id="174720.A0A0N5BY56"/>
    <dbReference type="WBParaSite" id="SPAL_0001071700.1">
        <property type="protein sequence ID" value="SPAL_0001071700.1"/>
        <property type="gene ID" value="SPAL_0001071700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001071700.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="52898" checksum="260277D7846EF00D" modified="2015-12-09" version="1">MYIYHSKYYITFTILSTLFFQYHALENNIENIKSEPLDLIQNDISPENPIHYKHFVIGIPGDLDNKHQIKLPGNKKIVRNKNKCIIGRKFNKPRRLKPKPPKPLFPRPKPLKPLLPKPKPLKPILPKPKPLKPICPGPICRKPPKPLLPKPPKITALPKPPKITTTKLPPRKPHGTKHPTRKPTTRKTTSKENKIIKPSPGRPSKGPIRPPSRPITITPSRITTKKPVLTTKKPAKPTKRPAETTKKHKVSTSRPASTQITTKKFSRSVKTTTSTRKPSSKPTTGSSSRTTTKKTVIRTKKPSPPPRKPASTTTKTATTQALTTPVPTTSSPSTTVPTTTQAPTTPAPTTSSPSTTVPTTTQAPTTLAPTTSSPPTTILATTQASTTLAPTTSTPPTTTQAPTTPAPTTPSPPTTVLTTTQATTTPVPTSPSSPTTTQASTTSASTTVLTTTQATTTPVPTTSSSSTTTSTTTQTPTTTKPKKECRVLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZI8</accession>
    <name>A0A0N5BZI8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZI8"/>
    <dbReference type="STRING" id="174720.A0A0N5BZI8"/>
    <dbReference type="WBParaSite" id="SPAL_0001117800.1">
        <property type="protein sequence ID" value="SPAL_0001117800.1"/>
        <property type="gene ID" value="SPAL_0001117800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001117800.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25322" checksum="958F92B9C286E1B6" modified="2015-12-09" version="1">MEYIKVKDINTYNDINTLIKICNLYVKKNLTSKEFSLYKKELYEKYKEILDFDDGNFHRLKTCNDGFTDSVMKFKNVQGLYDAVSKLNNQQYLIYAKLNNQQYLIYEKLYDKSIERFESVNRGIDFIPARILCDGPGGTGKSFLIDVLAASITAIIREKMNTPESKNQPFVLKVCLTGVASVNIKGRAIQSLFNLPVSKSKFKMKLRPLNTREKYSIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZQ1</accession>
    <name>A0A0N5BZQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001124200.1">
        <property type="protein sequence ID" value="SPAL_0001124200.1"/>
        <property type="gene ID" value="SPAL_0001124200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895099" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001124200.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27272" checksum="FB97C6B24AAB3094" modified="2015-12-09" version="1">MTGKFTNTFILLLFLHVNFCSSLSKASDKSLCNFVVDNIKTGKYTTEELFKACNPSSIHRNYMHRDTRAPSFSLKHSLFSNRMLFDHLRDSDGINKIFQKFKNHVDASGRNRYHPGFTSTGFDRMMKKTNFNKYMKLKLNKRSDNLPILKKKRDTTDRFQRSDPTDSDGFSYDFVRFGKRDTPESQDDSLIQSSLGMYGPLYKRSGKYQNLNFGKGGEEGKRGVGESTNYDFVRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0N5</accession>
    <name>A0A0N5C0N5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOC3-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar complex-associated protein 3-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0N5"/>
    <dbReference type="STRING" id="174720.A0A0N5C0N5"/>
    <dbReference type="WBParaSite" id="SPAL_0001156300.1">
        <property type="protein sequence ID" value="SPAL_0001156300.1"/>
        <property type="gene ID" value="SPAL_0001156300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="10">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="9">
        <location>
            <begin position="550"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001156300.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="89928" checksum="E9C3FA08245E8353" modified="2015-12-09" version="1">MGKIDLNPTRNHLKKTRKRLKKLTKKGKLKKHVRDGVNSIYLRKKKDLIKRRQNIEYDWIEDRMALREEENENDMNLVPIDMLTSTDIDWEKTPFKNERKRLMKRLRLEEEESKINEEVPRKFKNIEKESKSNNLLPVKIDGKVIFKEEVSNEPEIKEECIDDEVIEEEPEEEKEKNKSTDEVPIKYEKMSSVELLGLRKVELEKMKQHISIASLAIISNPEANTEKLKELLKYAIGKKTDELIKKDTQKIATASLTEILIDIIPGYHIREYTEAEMEQRMKKETKALFNFEKTLLEVYKQYLQHLETFIRPMTAKTSNALCQKSFEYKMGMISCKCLCKLIKHATHFNFAANAIKLIVRFAAYCLEEVSIECCKALSEIVSEDYQFRTSLCVAKEIASVVKDKKGNVPPRLLSTLLNLNIKEVDKKTENDEKREKQHFKARKNAIHKDRKSKSVSKYEKQLKKLEKDLKEAEAANTLTEKMKFGTDTMKHVFTIYFSVLKRLSKSSLLEPVLEGLAKFAHLINIEFFDDLIASLSQLVQDEDMRVLDTLHCVYTVFVILSGEGKSLNIDPVVFYKIMYKKISHIPFYNEDLRKKCVDISIQCINIMLNVRRKFVPTVRVAAYVKRLIAISFLLDSRCIVAILAHVRTLFISHRNLVSLVDCDDDEEGGSGLFYPEIGDPDCTQAMNATLAPDLKKLIGHPCKEVGIFAVHILAGCPSTGDNRLSLNYVNIPPTDFLEDQSIKLVPSPYKDGITKVAKKGNAKLEWKNLQTYVEKWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1D7</accession>
    <name>A0A0N5C1D7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1D7"/>
    <dbReference type="STRING" id="174720.A0A0N5C1D7"/>
    <dbReference type="WBParaSite" id="SPAL_0001181200.1">
        <property type="protein sequence ID" value="SPAL_0001181200.1"/>
        <property type="gene ID" value="SPAL_0001181200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001181200.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42050" checksum="0E7DD75E7D397849" modified="2015-12-09" version="1">MESMTIKFIIKPMLSLQTSTNTILFEKEIERKVTVDNNVLLKDICIDIMQNIGLKHLASNAKVSIKISESKYHTFESFIPNLDLNIGSLKPIFGSSLIFMILVPGKVEEFNAMELKKTFCSNFLHLIIKRYSSIKNCITDPIFKDIIESIENNTIESLSYESLLQMNETIQEELNFLNNFKNEQKILPNIDIQSYQNSNSLLLCSPINLNLKIPNTIPAIVPGINDKGNISEENTTTIPPQPYFTPTNKPFIEYHETLLNILQKTPPSMETPNIMEAVFPPTPKEGTLNSRSRICFDQNTETPILELWFEITRTPSPSQLQDYADHLNNLSNRSNEDKITSHNVKIWFKNRRAKENRVNKYFNNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Z5</accession>
    <name>A0A0N5C1Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Z5"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0001201300.1">
        <property type="protein sequence ID" value="SPAL_0001201300.1"/>
        <property type="gene ID" value="SPAL_0001201300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001201300.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33455" checksum="7BD1A45169236E61" modified="2015-12-09" version="1">MYPKGDEDENKDYISLYLVSEEWAYTDLLMKVGFYVINAAGEKKSLDFKNIQKFNKSPGKYGYPKFFKRDFLLSRNNKFMVNDTLMLGCEIFYSYSGQNNVNTSTICNVNKPLNTLINDFSSLLESSEFSDCVIRVGGSDINVHKCILASRSEVFDSIFKEKNNESVSNIIHMSGHSVEAVKEVIKYLYTAKLPNIDIMACEMLEIGDNFKLIHLKSAAEDYLIRNLDFDNVCDYFEKSKLCSAEILQEWCLRFIYLHPEIVNKRMEWKKVVTNHPLLVAKLLPMLANIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Q0</accession>
    <name>A0A0N5C2Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0001225900.1">
        <property type="protein sequence ID" value="SPAL_0001225900.1"/>
        <property type="gene ID" value="SPAL_0001225900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001225900.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14512" checksum="3966BADF37841055" modified="2015-12-09" version="1">MSTGLSPAQILLNTSDRWINEQPMHNGYSGLHELIKDTKDRFTENDIQRKGQKLNPGDLVLRKVMHRKDTDTSQKNQPTWEGPFKIMKHLYGDTYEIARVGRKTRSAIEKVHADRLKKYVEEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2U7</accession>
    <name>A0A0N5C2U7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2U7"/>
    <dbReference type="WBParaSite" id="SPAL_0001230400.1">
        <property type="protein sequence ID" value="SPAL_0001230400.1"/>
        <property type="gene ID" value="SPAL_0001230400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001230400.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42496" checksum="E2EB9F884B31CF3A" modified="2015-12-09" version="1">MNISKSSLDFNLEYYREKRKVRGNILERWFSLIPVYIDEKLDRELIIKALNIIQTETCVRFKLVNRIIVGMSGIRYCPGEKCASFIGRSTNRQFQNIFIAGHCQTVGVIQHETLHALGIDHEHNRIDRNQYVTIMTDNVDESLISDFSISSPLNSNTFGLPYDYGSIMHYDMDSFTKNNGSTIIPKHELYRKTIGQVEQLSFIDIKTVNMMYCRYKCPPTPFRCHNNGYSNPNNCLQCKCVEGFVGNDCGRFAVNPYSCGRTRFVALRTKQEIKAVGKINCFYHLLAPKNSKIVINIVFISIHPYTRKICLPNDSLEIKYWKDKTVTGARFCGINKNIIFYSKSNVVLIYYRSTDARSRFKLLFKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Z1</accession>
    <name>A0A0N5C2Z1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Z1"/>
    <dbReference type="STRING" id="174720.A0A0N5C2Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0001234700.1">
        <property type="protein sequence ID" value="SPAL_0001234700.1"/>
        <property type="gene ID" value="SPAL_0001234700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000009">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001234700.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48435" checksum="DF2E9D16D6B31506" modified="2015-12-09" version="1">MSTTEGDTADRNVEIWKIKRLIKSLELARGNGTSMISLIIPPRDQIARISKMLADEYGTASNIKSRVNRLSVLGAITSVQARLKLYNKVPTNGLVIYCGTIITDEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALQALLCDDSKFGFIIMDGNGSLFGTLTGNTREVLHKFTVDLPKKHGRGGQSAVRFARLRTEKRHNYVRKVAEVAVEMFIKNDKVIVAGLILAGSADFKTELAQSDMFDQRLQAKIIKTVDISYGGENGFNQAIELAADALANVKFIQEKKLIGGYFDEISQDTGKYVFGVVDTLHALEMGAVETLICWENLDITRYRLKTANGEEKIVHLRAGDEKGKDFLDPETGNEMESVEQMALLEWLANNYKSFGATLEIVTDKSQEGAQFVRGFGGIGGILRYRVDFNLIDVNPEEDFDLDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C385</accession>
    <name>A0A0N5C385_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C385"/>
    <dbReference type="STRING" id="174720.A0A0N5C385"/>
    <dbReference type="WBParaSite" id="SPAL_0001244000.1">
        <property type="protein sequence ID" value="SPAL_0001244000.1"/>
        <property type="gene ID" value="SPAL_0001244000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="7">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001244000.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27881" checksum="92C5164D77D927F6" modified="2015-12-09" version="1">MAEKKLPTVPETILKSRKIRAEAKAKAQEAKKKALVKAKLARGVAIRRAQKYAAEYRKKQQTELRLKREAKAHGNFYVPDEAKVAFVVRIKGINKIHPRPRKVLQLFRLRQINNGVFIKLNKATIEMLRIIEPYVAYGYPSLKTVKDLVYKRGYGKINGQRIPLTNNATIEENLGKYDVICAEDIVHELYTVGPHFKEVSNFLWPFKLSNPRGGFTKKANHFVEGGDYGNREEKINALLHKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3H0</accession>
    <name>A0A0N5C3H0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3H0"/>
    <dbReference type="WBParaSite" id="SPAL_0001251750.1">
        <property type="protein sequence ID" value="SPAL_0001251750.1"/>
        <property type="gene ID" value="SPAL_0001251750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001251750.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7688" checksum="D3BE42B03405F6A9" modified="2015-12-09" version="1">MWKKLEYYVWVIYQYYHYKYINDDSPMSMRETPNICDENLENFNGVKTILKSLTILCWKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3W4</accession>
    <name>A0A0N5C3W4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3W4"/>
    <dbReference type="WBParaSite" id="SPAL_0001264800.1">
        <property type="protein sequence ID" value="SPAL_0001264800.1"/>
        <property type="gene ID" value="SPAL_0001264800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001264800.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23372" checksum="E0E104CE41E69470" modified="2015-12-09" version="1">MIYQPSHSPESNLNKSISPESSIPIHIQSNSNPLDHKNVYNSRSSFIFPTSLQKTDNKNIEETNTNSNSKYIFSKSDCFDCIDIFDFEQDEQQLDIGYNNSDQGSSNDCYFSDDCESDFEGNQNYIENIYKCFDSNIDYDWGFEERTRPNEFSDVGDIIGYAKLVKAQRDAAMGELDSLLSQIDSVFGVIKKGFNIKKNQNNFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C443</accession>
    <name>A0A0N5C443_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C443"/>
    <dbReference type="WBParaSite" id="SPAL_0001272800.1">
        <property type="protein sequence ID" value="SPAL_0001272800.1"/>
        <property type="gene ID" value="SPAL_0001272800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895317" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001272800.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10533" checksum="8ECEE33BFC91D29B" modified="2015-12-09" version="1">MNHQTVVLFICYALLIFKFATTIPVFYENDNDGYYLIGEDNFQPVINDKVIEKRQKLHSFMGTEAGNKKPHGYSLKGIPLRLMSNFRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C473</accession>
    <name>A0A0N5C473_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C473"/>
    <dbReference type="STRING" id="174720.A0A0N5C473"/>
    <dbReference type="WBParaSite" id="SPAL_0001275700.1">
        <property type="protein sequence ID" value="SPAL_0001275700.1"/>
        <property type="gene ID" value="SPAL_0001275700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001275700.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60373" checksum="CDF7B4ADCC87DBC0" modified="2015-12-09" version="1">MDILNHQNSLEVVCRLRPSNTSNKDSKDSVVYIDERHIQLNGPSNSRSHNINKSIYTFGYVFDPFEEQRTIFDRSCKDLIQKLLQGENGLLFSYGITGSGKTYTMNGTHSDPGIIPRLSDVLFNSIPNIAQKCIFKNEGKNKVVIQSYADSIKDFKYLQGTLSYMTMIRDSEIYSNRIMDISKLSVFGDEKVATVFISYVEIYNQYVYDLLDNDSTVKKEIKLGTNGNTYIENVVEVEVSNSGELMSFFEKAQIKRKTAETALNFSSSRSHSVFMIRLVMGDCNEKGNYPIVNDVNVQQSQLFLVDLAGSERTKRTNAEGERLIEANAINNSLLTLRKCFEGIKINQKKKQKVIIPYRENKLTIFLKKFFEGSGYIRMIICINPQIEDYNENLHVLSFGQSSQEVSLNININKIEEFYTFTGGKFQFPKRVICKWFNEANETFSSKEYGLIDVLESKLNKYIWELCMEVRNEILKKCCYGDLLRQKLEACESELHKIKQSNYEADIRINCLIEQKNELEKKTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4T9</accession>
    <name>A0A0N5C4T9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncoordinated protein 58</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4T9"/>
    <dbReference type="WBParaSite" id="SPAL_0001296800.1">
        <property type="protein sequence ID" value="SPAL_0001296800.1"/>
        <property type="gene ID" value="SPAL_0001296800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF310">
        <property type="entry name" value="UNCOORDINATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="481"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001296800.1"/>
        </source>
    </evidence>
    <sequence length="664" mass="75962" checksum="A0306B48160A0784" modified="2015-12-09" version="1">MFFYSPHPKTTIIRRPTIFPSQLREIPPVVREALEHPPRSPTTIHHQPERVSICRRLNIDDPVVNVVEETTSSHLRRDRGIENAPFIAASVAVLPFALDSTSTQRAHSQDVQLETGGLNNNTTINNNVTVRRHGTISHPTSYLQLVHNVDDGGVLTPPESIISREYEHRRLSKVGKSIYLRRPTISIQEDGRIVIDHVGGRWDGIPLTSQAGLIDDDGATIITDTLKDDGEGKEPLTCPQQTVKYIKILIPHVILVSVLVGYLCFGAWILMLLETRTELMARSRKLVRLTNLMTNFTSHSWLTLNDVQNGIRSIDHEEWSSQFREYMVSVSELVDDRRPIRKELLQPDNLDNMHNKWTFPTALLYVLTVLTTCGYGEVSVDTDVGKVFAVVFALVGIPLMFITAADIGKFLSETLLKFVNNWNRITRQIKHHFQKIFCRKRYIRRKSLQEANGNLDTLEMLGIDGAEEKLWFPIGAYVGCICLYCSMGSAMFINWERTWSFIHAFHFGFNLIVTVGLGDIVVKDYLFLSLIVAFVIVGLSVVTMCVDLASTHLKAYFTRIHYFGRAKRFLGMSEELREIVALLGAMRKKKGGKVTWSDVRDFLDNELRDRPFEPHDLLMKMRFIDETTSQMNTIRHNSFQSDFFRDNEYFRRLVALRPEQPAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5C0</accession>
    <name>A0A0N5C5C0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8077 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5C0"/>
    <dbReference type="WBParaSite" id="SPAL_0001314900.1">
        <property type="protein sequence ID" value="SPAL_0001314900.1"/>
        <property type="gene ID" value="SPAL_0001314900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058390">
        <property type="entry name" value="DUF8077"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26284">
        <property type="entry name" value="DUF8077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8077" evidence="2">
        <location>
            <begin position="37"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001314900.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49938" checksum="5E649C71F2FDB326" modified="2015-12-09" version="1">MSRRNFYSIYINLFIILIYLTSLAATNFHHTDPSQAEVEYVDWVTGVQVVFCKDTFVTQADIENNFKKSIVNVLNKHCRNSTACGLRKPVSFTPQNIIFMEGFPRREYEAINFRFLIVLPTESIPLKKISKPLLHKQYSSDAFKKFLVEEITNKLGWHVLYFEKYPKYDRITEFMNVALIPIALTAGLLMICLAYWSTCLNSVAFNNGDWIVSGASGGKNAALRRTMEIINEQEAFFNQYLKERQYYENFSNKENDEKKKDFHEMEINNIPQFSKGKEKKDCRTVKNFPGNESYEMQEWNKEANRVSDNHLSTIPEENVEKNPPVYKNDNKDVVIRISRNNSDSSLLTQEQEAQLFAKIQERNRRRISVLNFNPDVLKEIKRMKRHHIHRNSMFSMPSPKRKSICSPKQKHWKTGSIMFNFMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5H2</accession>
    <name>A0A0N5C5H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T9SS type A sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001320100.1">
        <property type="protein sequence ID" value="SPAL_0001320100.1"/>
        <property type="gene ID" value="SPAL_0001320100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001320100.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12177" checksum="3994CAFE8BD8D405" modified="2015-12-09" version="1">XDIHGKETSLIEIRNDIYKFQEGEKAFVNIEYKGINKNTSNYNIRCYKNNKIMVNFCPRILFKGTNLIALGKMTKVMEGDYIIQLINKHGNVKDFGTFSIQLKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5K9</accession>
    <name>A0A0N5C5K9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5K9"/>
    <dbReference type="STRING" id="174720.A0A0N5C5K9"/>
    <dbReference type="WBParaSite" id="SPAL_0001323600.1">
        <property type="protein sequence ID" value="SPAL_0001323600.1"/>
        <property type="gene ID" value="SPAL_0001323600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001323600.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12127" checksum="B456C08806FB5037" modified="2015-12-09" version="1">MASSWSSSENVNDITIDENSLSEDLLRDIELFSEHINRLRISLDSSSYVPDGESKCVQVHAALSMVSQSVRDLLVRYPLFKTSHVLIPTSQLVHSIKGNIIINKIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5V5</accession>
    <name>A0A0N5C5V5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5V5"/>
    <dbReference type="STRING" id="174720.A0A0N5C5V5"/>
    <dbReference type="WBParaSite" id="SPAL_0001333100.1">
        <property type="protein sequence ID" value="SPAL_0001333100.1"/>
        <property type="gene ID" value="SPAL_0001333100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333100.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="57166" checksum="7283CACC35CB3D8D" modified="2015-12-09" version="1">MIGIILITAILIYLFNFYRKVKSLPPGPMPFPIIGNLFTFDFKKTHLWINDQKKIYGNVFTIYFPGPLVVLADCDSINEALVINGDNFLGRNVNGYPDKAFHEKLNVGVVFSEGEEWRDQRRLSLHILRDFGMSKTIIQDKIHLVVQDIYDHIDRFENKNNANIDKILQLSVGNVINQILFGIMYHNAEVNEFFEFAEALEEFFKETQGWEFRLLLFFPFIDKIPILNNYLYKRITRAQRKMRELAKIQVENSRKIYNPDDEPPNFIHAVLKEIQSKDSKYSYLNSDHLEGMVLDFWIAGVETTYTTLKWFILIVMKHLDIQKKLQDEIDEVIGKDRLVQLSDKSKLPYMNAFINESQRYANIIALSPKHKCTKDTIINGHLIPKDTIVEPFYWGANIDEKYFKDPSVFNPNRFLDDEGNLKIEHEHMSFGKGKRICAGKSLAEDEIFLIFTSLLQKYKFTHSNRAVDLSFDFSGVIQPRPYTCKIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6P8</accession>
    <name>A0A0N5C6P8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6P8"/>
    <dbReference type="WBParaSite" id="SPAL_0001361400.1">
        <property type="protein sequence ID" value="SPAL_0001361400.1"/>
        <property type="gene ID" value="SPAL_0001361400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001361400.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42784" checksum="7D068A584D27D641" modified="2015-12-09" version="1">MAPNNHIKEVFANILGRRGRKIFFEPSTIIHIHKKKHYNDIKEKSKYKKDDSQLIKTTPIPQLPEEIWYKILINITDPFDLLKMRRVSKIFKSTIDNYMKQKLYLNILKIDLNEVELDTINKNDCDNCLNLPEENIRDGYSNGHYKRHKKCQILLSISSRNVVIIVDERWTNKDVQCIWHALQYFSQFAHTVNLDCQIFELLSVALSPMKLSRWYTFECYLGSIGLPDADGYHMKPSSHNCGKTFTSCAAIAGNHKNPNNHLDHHLYVNLDDSYESDVSLFEKCKELTIRTTPYDMGHLSRIPDYHVHFTSIFNPENIEIIRISLVNVHEKLPLKAKKVKDHLNIFKKWIESNKLGEKFVVQRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7S4</accession>
    <name>A0A0N5C7S4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7S4"/>
    <dbReference type="STRING" id="174720.A0A0N5C7S4"/>
    <dbReference type="WBParaSite" id="SPAL_0001398500.1">
        <property type="protein sequence ID" value="SPAL_0001398500.1"/>
        <property type="gene ID" value="SPAL_0001398500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF145">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001398500.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="96140" checksum="37318225B1BBC490" modified="2015-12-09" version="1">MDVEDGNLNATFRHILKEKPPNTAYIFEDKDGFYFYGDDAILASEQIFGTDSLMDYIKLDNKSEEAVARYFFVANHYDKVVRDLLIRLQYSVKHYIIEEGCDWDLLYEGTPLDPNDFGYIVGETAQLASLCSTISVRLTNNGHFNELVEVAYCSTKDYSISTFVLPYDVNFQNLEHIIIILAVKEVFVTKEDMEVIPDIFKKFQSVLNKIQVPVKFLEDEGNQEVEVKGAKDIVTRMTSNTEEIDQLSDSMIINLYVLLKNMDIIKDFSDQAGLLCYRKYPLNNFVVLDSAAVEALELFNIVTKSYSADDNKGTVFSLLNHCRTPSGCRLLEEWLRRPLVHVNMVNERHDIVEAVRNEPSVKNVLYESFLRRVPECISISRRLIIKKGTLRDCVEIFRLAKSLYKLSTHFEQLALTSPNCGDSVNSVLQKPLEEIEQSLTHFVKVIGKVVDFDALINFGDYRIAPDVDESLSEINVLMGDLESKAKRVFESVQKAIDDPSLKIESGENGFTLAINPSGADLVDKSKYHILRNTKATGVVFVTDVLEQINEVYVNCLKDYKERESSYVLKVLEMAYDNTSTINAMFDFVAQLDVFVSLAVFASSTTKSFVRPNILEHTNIEEERVLQMTQLRHPVVETSPNVEFIPNDIKLSSYEGVGPRFVLITGANMGGKSTFLRSVALGVLLGQIGCPVPCNEAIYTAVDGIYTRIGARDYQDKGISTFMDEMLDCRNIVYGATPNSLVVVDELGRGTSTFDGIGLAYAAAEELIEKNCFTLYATHYAELTELKDKYPHIVECLRADCAYSESGELMSLFKMVPGVTKKSFGLDVARTLKLPEDFLQLASSYYQRFSNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8G9</accession>
    <name>A0A0N5C8G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8G9"/>
    <dbReference type="STRING" id="174720.A0A0N5C8G9"/>
    <dbReference type="WBParaSite" id="SPAL_0001421600.1">
        <property type="protein sequence ID" value="SPAL_0001421600.1"/>
        <property type="gene ID" value="SPAL_0001421600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000036">
        <property type="entry name" value="Heat Shock Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF35">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421600.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12534" checksum="F3FC57F0A45C20CA" modified="2015-12-09" version="1">MATSTIPVQSEAAGSWDWPLQQADGVVKVHNTNDKFEVGLECYFFAPNEIEVKVSGNEVLIYCRHDSRNDEYGSVKREIHRAYKLPSDVDVSTVKSHLSSRGILTISADKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8R3</accession>
    <name>A0A0N5C8R3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8R3"/>
    <dbReference type="WBParaSite" id="SPAL_0001430400.1">
        <property type="protein sequence ID" value="SPAL_0001430400.1"/>
        <property type="gene ID" value="SPAL_0001430400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF8">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001430400.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44292" checksum="68683B5C9B595EE2" modified="2015-12-09" version="1">MRNRTNVLFAAMAFADLGFLLLSLIPCVYMKWYGYLPGWFKAFYIRNNILTTWLINWLSAFSIWVMLAVTIERLAVVRRPFAHYRPMNFVFGIKILTILILSLFVTLHNYLSIKTENDNSGKYVHTKITDNPIFTIWGWVHALSVVVIPNIVLLSCNVMLITNLRKQSFPIELAQENNQPLIISRTKIEKKITYLIVIILTTFLACNMPGAIIFLLRTLNISFKDRYYNQLLQVISNALTTIGKVLNFGLFCLSSKHFRKSLIEQLKICCFYIRHIPNSCGRTKSSYLQDNKYVNKLSYCQTESVRLSTRDRLMTITTTPSPGNSSRLSKSYHHSFHFPIMVNRTSGDSGSMSVEYSSKNNYNPRMRSEIVDTRVVAKRAASTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9R1</accession>
    <name>A0A0N5C9R1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9R1"/>
    <dbReference type="STRING" id="174720.A0A0N5C9R1"/>
    <dbReference type="WBParaSite" id="SPAL_0001464000.1">
        <property type="protein sequence ID" value="SPAL_0001464000.1"/>
        <property type="gene ID" value="SPAL_0001464000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001464000.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55646" checksum="FB1A8FB458314B17" modified="2015-12-09" version="1">MEEKIIVNTVLHFLQKYKTMNDIENIIYDGFSTNIVNEAIEQLNLLLTENKMNNDIENLSLLELYNKLINYCTENNILVPKFVIDDIESVPKNLFAKLTCESKLDAITDEIRCLRKTMEEIRQRSQQGDKRVSPRRKKRRLSAELRSQKNGTSLADDCSSSSGDLQHSAHNSFCSSSSSSTSLIGSVSSPPRCLTNDIGTGNQNLSAYLSNHSTPSSTTIPSKDSSRRTGGKLANCVQRLTDRLGSQKESVSPNDIETSDSPSSEIDNGIPSSPATTGILFENFLNQGIPLYTALNPNFFTKKIHPQIGNPFSIDPSLTSTPTGPNMEYLSLLISNAARNLTSQNKQFPITVPTTTVNDDLISSSQKLNINEKESSIKMEIDSCETEKLWSDINPSLSNGNIIDFGGNQEETKSDSDKPFVCEQENCNKRFANKFLLKKHQFIHTGLRPHACPYCQKRFNRKDNLLRHKKTHTQAGMSIDESKRCGFLINNETAGDLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAK0</accession>
    <name>A0A0N5CAK0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAK0"/>
    <dbReference type="STRING" id="174720.A0A0N5CAK0"/>
    <dbReference type="WBParaSite" id="SPAL_0001492100.1">
        <property type="protein sequence ID" value="SPAL_0001492100.1"/>
        <property type="gene ID" value="SPAL_0001492100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001492100.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13878" checksum="DB6EC0A053346BE4" modified="2015-12-09" version="1">MVLTDPKERIISVIGDEDTIVGFLLGGIGKIDKCNRRNYFIVEKDTKPSEIEEAFISFTERDDIAIILITQHVAESIRSVVDNYKKCIPAILEIPSKEMPYDPSKDSILNRARGIFNVEEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAS5</accession>
    <name>A0A0N5CAS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAS5"/>
    <dbReference type="WBParaSite" id="SPAL_0001499400.1">
        <property type="protein sequence ID" value="SPAL_0001499400.1"/>
        <property type="gene ID" value="SPAL_0001499400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF51">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001499400.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25319" checksum="82E84B47B3A20CE9" modified="2015-12-09" version="1">MCRIFVGAITSILTIFGVTLMILAVITPAWQVVTLTDLHVIHEHGLWLDCSSTNPTFRDIFSSDHRCTNKFINFEFSKKENDMKIDNGDANSHKLHRWHQVMLIFFASSIILAIMGQAFLFCAFCFPISGVVANLFLLLSFSTASMAMIIFHIYTNKTEFRFISVMLNVYEQKTGYSSIIGLLAVLILLIAFLASILLSVLLFIYDRKRHNISKTFPKFSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAW4</accession>
    <name>A0A0N5CAW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAW4"/>
    <dbReference type="WBParaSite" id="SPAL_0001503000.1">
        <property type="protein sequence ID" value="SPAL_0001503000.1"/>
        <property type="gene ID" value="SPAL_0001503000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001503000.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32982" checksum="AFC664581A00D6F0" modified="2015-12-09" version="1">MALKMVEIIQLSYLVPSLILMAFVFCFLIKKFVTRSSIFCNEFYPLLSFKILNDIIYHLTILLFLKLPLWKINEQFYIDNHFLSTLSYFLGAATVCVQFLHSFILSLIRFIAIHYPLKYKLFFSTNTIVYIITSMFICCIVIAFPSIFFESRYIYDSKAKTLSPMYINLNVTYYQIFYTVVIYGSTTIISFTLNIINIISLTKKTTPLNNRNFEKLYAIYTIFTLFGTTLLEIYLVLRIIGTYSENNHLVSIASSFLTWAGDVATLGDFYFFLIITYVENYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAZ7</accession>
    <name>A0A0N5CAZ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAZ7"/>
    <dbReference type="STRING" id="174720.A0A0N5CAZ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001506300.1">
        <property type="protein sequence ID" value="SPAL_0001506300.1"/>
        <property type="gene ID" value="SPAL_0001506300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF59">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="33"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001506300.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41776" checksum="FBF30C88D008AA8E" modified="2015-12-09" version="1">MSRFGIFLILFVITNNYIITTTYSYVPPFDFSRYHGYMEIKQFINDVAANNPSFVKVVKIGHSHEGRTLEGLKIGNNINNTSKPIVWIDGGNHAREWPAAHFTLFFIKELVDGYRKNDDITNYINDMNIYVFPLLNPDGFVFTKTSKKSIIRQWRKNKAPENCTGWTHFKKGVCCDGVDLNRNFDIAFDYNSESFGNPCSDEYQGPHPFSEPETIALRDFILSPEIKGKLKGLISLHTHGQFIVVPYNYKLHEYPPDYDKLMELGEKIRTSIKAQRGTEYQLGTAADLFKMPASGGAIDWIKKNTNVSYIYVFELPPEWKTWFAFQMREWHLVYTAEETWQGVKTFLKRCYQEFVTGMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB28</accession>
    <name>A0A0N5CB28_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB28"/>
    <dbReference type="STRING" id="174720.A0A0N5CB28"/>
    <dbReference type="WBParaSite" id="SPAL_0001509200.1">
        <property type="protein sequence ID" value="SPAL_0001509200.1"/>
        <property type="gene ID" value="SPAL_0001509200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001509200.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77063" checksum="E033EC55491BBBD2" modified="2015-12-09" version="1">MDGEVSNVKVCVRCRPLSKKEIEHNEQIAVSFNKIEKSITVKNVDNSEEPSKTFTFDEIFDMDSSQITIYNTIARPLIENVLKGYNGTIFAYGQTGTGKTYTMTGIPDVPEQQGIIPNSFAHIFDHISKCKDDKTFLVRVSYLEIYNEEIRDLLVKENTKNLEMKERPDIGVYVKDLTTVTVSNADNMFKIMEIGSKNRSIGSTNMNEHSSRSHALFTVTIECSETIGNTQHLVQGKLHLVDLAGSERQSKTGASGIRLKEASKINLSLSTLGNVISALVDPKSTHIPYRNSKLTRLLQDSLGGNSKTLMIANIGPVGYNYDETISTLRYANRAKNIKNVVKINEDPKDALLRKFQQEIELLRKQLEGADIDNSEISDQEGDETTSYSETNAENRDDRWNEKIAEKEAEIKQLRLDLEKKQKGVDDGEREKILLELQAKEDELEKSRNEHYALKAKLHQIEKNIIIGGENLLDKAEIQAKLLEESNIELEQSKQSEEELKKVLKEKEAERLDIEEKYSSLQEEANGKTKKLKKVWTLLCDAKEELKDVQEEHQREMELLLDNVRQLRKELMLYLTIIDNYIPEEYLELIEKHVSWNEEIGEWQLRGIAYTGNNMRSTKGAPPRVVKKEDPQMKNVYLSYANILGGMTHPPSVASRTKARLKSAKKERNAAALRALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB64</accession>
    <name>A0A0N5CB64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dimer_Tnp_hAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB64"/>
    <dbReference type="STRING" id="174720.A0A0N5CB64"/>
    <dbReference type="WBParaSite" id="SPAL_0001512600.1">
        <property type="protein sequence ID" value="SPAL_0001512600.1"/>
        <property type="gene ID" value="SPAL_0001512600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="966"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001512600.1"/>
        </source>
    </evidence>
    <sequence length="1244" mass="139120" checksum="A576098009CBB0EE" modified="2015-12-09" version="1">MDINLDITTSSDGVSEQKKMKLENVDGKCKNHIENGISSSLASLFPKNDDNGSGDVNVDWRNIFSKVTSNGIFKCEDGIKKDSENLGNSPTENTTKSENAQRSNNNNNNNEQKSNNLQNVLQNMNNPIATMFLASHAQNILRGSGNIPTSQPFNPMFMPFIPGMGNCENPQQLLQFLQQQIGVNGNDPQLMQMYMQQAQNYFKNPENKEALKQTLLASHRGSSQTPMSTTPPTVGIPGAVAVAASPAAALFPEDDWSWHRNPAAAIRSGGTNKQTPVWKYFVYNKQENISRCIIGDCSYMLKGPHTSTLACHLKKHPVEFAEFQRLKQEYTRERSVSQLGNSTTPTFKNSTNHSFNNFNNGGNYHKSSGIFRNDNNINRQIISNASVFTGNYNKMRGNINVVSGGGKNNHFKQHPNMNNIWNALSAKAHSQVRNYQNENNNDKGGNGQNNQHVQLNGSINNNMLGNVQYNPSELLNIMTANINSFLPTNNNERNDNKEEKIGVKGDEKETTSPGSINNENINSGDNSSSENNDSSIFSRSPSNILSSTQGNDDKWMKEDKKQKELEVKLAMMLGTTQLPLKIIQNSDFRNFLKMAQPKFDIPVEVKDIDEILNNKYNQIIDVLKKELSKLSSYTLMIDLLKISPKTIEMEILNSRKRKHHENVMLNDGECNLRSSNESIISFPPSIQSDVTIISDDSCVNTSSINLPNLQISPATVSCSSSISPSQISITPSTYDEKNGTFESLKRCYEEFRLCVSVAYYNKDTGKIEIVLLAVRPIVFKDEEFKNILRDIVKTILQEYNIDIEKASKILTHGLSECGIDGNDLFPKQMIPYNFKLHQFLKKVLNANSTVQNLKKAFNHMMHPFLCNQQNIDEFNKHLAEYGQEINQFDSFFKLASAVLSAKETFLTIFLRKVNFNSSSVMMNEEKWNQLDQLIQLLKMFNDHTSRIIGNELTTIDKVVPSLMQLKVSLERGYNGFEDLCQELKNELNMATANILDTESQNFDSTFIEATALNTQLAVLLDDAQIACAKTAIEKALTKRMNFQLNESASIDQSTNLQFASSPSLSSASSTSSEGSSNNVGSSAISHPASSLFPDLLQAANQRRKQLQDNNKNNENKKNIMVEVIVQSYFDSIYSSNNQAFSLFEQSSRDNQSLNPTTSINTQLPPLEFWRSYSTKSFHLSEYAIELLSIPVSTLSIQKIFNDDDHGSSLSLLNKALGDTNTSIISINLDSFAITKALETPTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC50</accession>
    <name>A0A0N5CC50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC50"/>
    <dbReference type="STRING" id="174720.A0A0N5CC50"/>
    <dbReference type="WBParaSite" id="SPAL_0001545800.1">
        <property type="protein sequence ID" value="SPAL_0001545800.1"/>
        <property type="gene ID" value="SPAL_0001545800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001545800.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17605" checksum="8A2E9B4AC3EC9D28" modified="2015-12-09" version="1">MEILNSQLADTLSKVVLKRIVEDNLYCAEFTGTKRTRILGSLLSSISMEQLSFVEELEKNSVKSLLHSAVNFLSPKKSSNLLSSFEHVSNLSDISGNLEVDTPRTFLQLGKYNEKSDPIGNFISDFEDLLIVHNIIADQKKKAALRSLLPCTLRDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCC8</accession>
    <name>A0A0N5CCC8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCC8"/>
    <dbReference type="STRING" id="174720.A0A0N5CCC8"/>
    <dbReference type="WBParaSite" id="SPAL_0001553800.1">
        <property type="protein sequence ID" value="SPAL_0001553800.1"/>
        <property type="gene ID" value="SPAL_0001553800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001553800.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26622" checksum="52568EBFD8530026" modified="2015-12-09" version="1">MPETLECNDKIIKYLSSEEVSSLIKQSNYKNSNELKDIDKSDLIPNIYEGGLKVWEAAIDMCNYITKNGNDTFKGKTVLELGCGAGLPGICALLLQSSHVYFQDFNEVVLKCYTQENVKMNGFNGNQTTYISGDWKYFNDKVRESGTKFDIILTTETIYCEENYEKLYQVFCDNLKDTPDAYILLGGKLYYFGVGGSILGFMDFLKIKNDFNVEVVDVVEASVPRWLLKITRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU8</accession>
    <name>A0A0N5CCU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU8"/>
    <dbReference type="STRING" id="174720.A0A0N5CCU8"/>
    <dbReference type="WBParaSite" id="SPAL_0001569800.1">
        <property type="protein sequence ID" value="SPAL_0001569800.1"/>
        <property type="gene ID" value="SPAL_0001569800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36520:SF4">
        <property type="entry name" value="DUF3421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36520">
        <property type="entry name" value="PROTEIN CBG13000-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895743" evidence="1">
        <location>
            <begin position="26"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569800.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55636" checksum="2CAE81C2F8BA7B7B" modified="2015-12-09" version="1">MLWQYYFLILFFLSIIFITNPQILGSQEPFFVNRDKKAQFPELITADNFPLFPFTDQFNFGIEVNPANKVAYASDINIPVPGWGNWDMDSTLYTGHINTDTRVGAMAKPTNRLNIKPETLSLLGQNPAFRAARKNAKEVLVGKLPYNYMPLRCKPPYCNPFVSFVAAGSEFEEGDDIFFIGGLDFPVPIGPSGQGVRFPLSGVVEYGTSPVSYMHGNAYNPSSPFDFTKIDNVRRRSLEPHVVNGDIKTQQFPELITADNFPLFPFTDQFNYGIEINPANKVALASDINIPVPGWGNWDLDANLYTGHINTDTRVGVQVRPTNKLGIKPETLVLLGQSPAFRAARKNAKEVLVGKMPYNYMPSKCKPPYCNPFVHFVTAGVEVEEGDDTFFIGGIDFPVPVGPNGQGVRFPLSGAFEQGTSPFAYVHAHAYNPSTPFDFTKIDNVRKSPPKKFLVDKKEDEGEENDKYHASSIKLRKKRQINIIRNLPKYYYLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCY8</accession>
    <name>A0A0N5CCY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCY8"/>
    <dbReference type="STRING" id="174720.A0A0N5CCY8"/>
    <dbReference type="WBParaSite" id="SPAL_0001573600.1">
        <property type="protein sequence ID" value="SPAL_0001573600.1"/>
        <property type="gene ID" value="SPAL_0001573600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895960" evidence="5">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001573600.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17334" checksum="C12347269D370528" modified="2015-12-09" version="1">MIINIFIYFLTFFYGTINQNLNTSLGTVKIGIILPNTDPNLVYWQGYPNSAAAVTRALEAAREKNTILNKVNFEFVWTMNECVASEAAGELFNLINVQKVQVLFGPPCSNTANVATNIAEYYDIPLYLFGISGLHEITEISTYKVVTSIMPSYSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDP9</accession>
    <name>A0A0N5CDP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDP9"/>
    <dbReference type="WBParaSite" id="SPAL_0001599200.1">
        <property type="protein sequence ID" value="SPAL_0001599200.1"/>
        <property type="gene ID" value="SPAL_0001599200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895988" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001599200.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23748" checksum="382A1D49F3D4F90A" modified="2015-12-09" version="1">MIHWKLIYIFFLLNCYHISTIFSCTNNDELGIISNPTFSLTFQPPAAWTYPLSTAEETLSFFPGQPMSQTSAQNIASTDMESAVIGAFKEIGLPPDGITVTSTYIPPQYHDCYKNSAASTELQSLKVGSTFQIFENGVITRTATIGGADLTYDICLAQSFSENSITLTYTEISLQATIKIDNFSASKFTVKQIASLITTKLVFGRGVKFLKEIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE27</accession>
    <name>A0A0N5CE27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE27"/>
    <dbReference type="STRING" id="174720.A0A0N5CE27"/>
    <dbReference type="WBParaSite" id="SPAL_0001608100.1">
        <property type="protein sequence ID" value="SPAL_0001608100.1"/>
        <property type="gene ID" value="SPAL_0001608100"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001611800.1">
        <property type="protein sequence ID" value="SPAL_0001611800.1"/>
        <property type="gene ID" value="SPAL_0001611800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009790776" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001608100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001611800.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14946" checksum="E79CF97BD379E084" modified="2015-12-09" version="1">MCCCCCVVIVFCLLASVSNIVNGITCHNYTSSEVSTGALTGQATCSGSYCLYEKIITNGETRIARDCSDIGQIVYTGGYFTDINKCFETTVGDTSYSLKICNSGDYCNYACNSGLAPTQSSTTILLSTLLVIFSIIYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEW0</accession>
    <name>A0A0N5CEW0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEW0"/>
    <dbReference type="STRING" id="174720.A0A0N5CEW0"/>
    <dbReference type="WBParaSite" id="SPAL_0001639700.1">
        <property type="protein sequence ID" value="SPAL_0001639700.1"/>
        <property type="gene ID" value="SPAL_0001639700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001639700.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37869" checksum="2844D4FF4A1CC176" modified="2015-12-09" version="1">MTSKYSQPVKLFSFYNEKQEDGQNSYIFGDKSIPVFHRSPGVLTSPLDIVAGVDKYFVEPYSPTIPCQWDLLAYIHNTVGLSLQHILDHSQVVCYRGFLKNLALIPLKEHFSHSYIVFMYNGIVFIERIETSENSLSKKEIEKQYMKKKLSKFCTEQSVDKYSNVDLNENYFVTKTRVFQTAKSTIKVMFTEGADAKNPHSKSEENDSMEIKICPGHITHIFKGLALYKTWAQSFISGNEVIAVGIRKDTVVKEIKLVHVSDLESKLPLPASKIMDFVGGCLEGIIDGCKKYPGKCFIIPKDEFALRIADEETVRRIKFSNPTNSFLEAFPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEW4</accession>
    <name>A0A0N5CEW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CEW4"/>
    <dbReference type="WBParaSite" id="SPAL_0001640100.1">
        <property type="protein sequence ID" value="SPAL_0001640100.1"/>
        <property type="gene ID" value="SPAL_0001640100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000242">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000189">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000017">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000580">
        <property type="entry name" value="Wing blister, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="19">
        <location>
            <begin position="56"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="429"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="18">
        <location>
            <begin position="554"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="797"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="915"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="967"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1014"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1062"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1112"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1207"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1253"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="18">
        <location>
            <begin position="1321"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1566"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1673"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2282"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2494"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2685"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="2967"/>
            <end position="3138"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="3143"/>
            <end position="3326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2908"/>
            <end position="2950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1937"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2075"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2138"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="2925"/>
            <end position="2943"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1253"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1585"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1673"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1675"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1694"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2647"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3299"/>
            <end position="3326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001640100.1"/>
        </source>
    </evidence>
    <sequence length="3330" mass="375161" checksum="202AFFE4289809DF" modified="2015-12-09" version="1">MGDRLLSLPSTIFLIKLLVFFLLINIFLPTYGNNIEYAPYYDDRYQELTTPSEEKSERGLFPTIFNLATNAKITANATCGQRGPEQFCKLVEHIIGRSPQCDYCDANNKYKRHPIENAIDGTSAWWQSPSLDNGLEYEKVDIVIDLRQEYKIAYIIVKAGNAPRPGTWVLEKSLDGINYTPWQYYAMSDSECMRQFGVPATIGVPKFKSDDEVICTSLYSKREPLEHGEIHTSLVNNRPGVDQPSKALLEFTRARYVRIRLLKLQTLNADLMIINRQQGKLDASVTRRYFYSIKDISIGGQCICYGHADSCPSDPETGQFKCHCQHNTYGDSCSQCLPLYNQYPWKPGTNFEHNICQPCQCFNHADRCEYDEQVHKQQLSMTPDGIFEGGGKCIACKHNTAGINCEICKDGYFRPGGMSHYREDACRPCECNPEGSETMNCVRDESEASDGKNPGDCHCKPGFGGRQCDRCAPGFRNYPFCEPCPCNQAGSLNFDLCQEDKCICKSNVEGISCEKCKEGTINLDINNNEGCQKCFCFGLSNNCVEKKWKQDYIRGTTGFNLTDWQNVKNIPMKGDQETDILMYTTTDYKNEQPLQYWRASSQYSGNLLNSYGGNLKYFVYFVPSQQTQVAHIADIIIEGNGIQLEYHSRQEFFPRENNSVIIPMKESSGWYNSQSRSPVEKIDMMRVLSDVQYLLIRAVYRNGQVQSTIYGLSLDIARENDDFEEEEEDNLLPSANNSLPLNIETLHTMKSKPTKYYMKSVEVCECPENFEGNSCERCKKGYRRVNNQLYGGRCEKCECNGHSEECDPFTGACINCQHNTTGDHCEKCIDGHVGNPILGGIIGGCSPCACPSLDNNHSKNCVLSQLGIHGILASNQEDNYICTSCDPGYDGNKCEFCADGYFGDPLAINGSCKPCECNNNIDPLDIGNCDTKTGKCLKCIYNTDGDHCEKCADFHWGDADKQTCKPCGCHSVGSLSLTCNNMTGICDCKENYIGDQCNKCISGHGDIENGCPKCDCNELGSEGTECDEISGQCSCKVGVFGKHCDRCLTNYFNFTIDGCQYCHCNQFGSVDGGNCDSVTGECECKPNVEGTMCEKCKEGYFNITSGNGCVECECNSIGSESLICNEATGVCKCKHGVTGDKCDKCEVNYYGLDENGCKKCQVCKAEGQVCDPVTGECICPPNTVGEMCEECTENSWDYHPLRGCRKCNCDTIGSIDGKCNSLTGQCLCKDGYVGPNCNLCSNGYFNFPNCEPCNCNTNGTLPSQCNGDLCLCDNDGQCPCKSNVMGLKCDECKENSFSLSGSNIKGCTECFCFGRSDKCEQSNLYWQQIYGPDREVTFSAPFIAFTKKHNIRLLKEEPAKYFSYPTDSTPLYWPLPRNFLGDKITSYNGYIRFKVYNNDYRNGNSPIKPEPIYFKYFPQVIIIGNDRLILEHIPHEISNDGKYKVHIHESQWRSKSTPQVKVTRGQLMTALQNLQAIYVRATYNYLVPGDQAGMKEISLDVGIREEELGEGQLAIKAIGVEECLNCQSGYDNSSCQNPSSGYYRKKTVDYLNSPNDIDLIGYSVPCACNAHSVKCHPESGRCMDCQDNTIGDYCEYCKPGFYGNATNGYSDGCIKCECPSIERSFSDTCIPISHGRGFMCDSCKKGYTGMYCEKCSDGYFGDPSIENGKCEACNCNPHGSVQFTCDKKTGQCECRDGVTGRSCDLCEERHAFIDGVCTTCDKGCTKELMFMVDQLEEQLLMSNFSNLKPVPWKRISRIENTTKDINTFIHNIKVDNVTIDKLDPSSYLTDPKVLLDESNFIMDRQNKTYGQLLQYIKDAESIYDEGRKQRRLIYDVTAQLRQFTLSGGAKLPIVEVDYLITEGKEFLEGTKKRGEYIDKRFHSGMSAYNKSRDLLDQVFKKKVNESTFKDIKNQLDDFIDMLEGYQDTLWDNARINTKDATNRNNALLQKVDNLKKIVSEIEEVESDIKDQLNESENNVNKAKQEKLLEMFDHYNEIKETLKESLNDKITALTTFGDTYGEAYNKLHHDVIRNQGKAKTLEHEANRIKEAFANTKHATELPVQASTAYKDIIEAIGNSTNAVEEAIESIKEAEEHADTSNEESLINLAKKSSEFSKSLKDKANEIARIWDEEYLPEKNQELKDRLENLSKSMSDSEKMLKNFQEKFSNMEDQKERLELYPSSLEGTHKKASEIKTTSENIAEEVSNLEKEFSNLGSSTGNEIKMVIDQVHNIGGGLTTDEDRIKNMGHLSEKNGKKIEELSQKLGILKDRIKEARERASRIKLSVTSNERGHCVRSFISPIYPSPSNSFNIKYRPARDVPDSLIMITMTKGRRTQASEYIAIALQDQRIVAHWNIGSGKRSATNSHPIRYIPSSDRFTWYNIDLKRSGNSVILKVVQEQSAPGDTPKKLTEEVSVMVGKIDGDSNVIFNTVPGETKIGFGYEGEKSISNLLSLKTDKFRGTVGEFVVDNEKVNLWDFSSSTKECDGGVSPFTPTTGGFMFKDGFAQVHMTTAERANTMLTVEFSSYSKDGLLYFRGNPDVKDFVSLELRDGQVVFKVNLGNNSFVKVTSKGPEYNDGKVHVVRTIRFTNQIHLQVDSEQDRVSETVPGENTALNVNENDHFIGGVPSDFDTLPFSQFDIHWKGFYGCIKSVKPNQISDLDLENVVRSHKKESGCGYKENQLEPSDRVIGFEKEGYFITNGIKFDYNSSISFNFRTRDENGILLYQTSTNLDKSKKIKRNSEMDGKGFIAVYLFKGTVVLNIGFDATIRNEMISLKSRSLYNDGLLHSVFIAREEDKIYLRIDDKEILKDSLNNDLTIGSLDHTVYIGGVDNQENINENELPVKNGIIGCISNVYYNFELLPLVPLSHSSIIGNCPSSLKDLLSSHDDTIINDEEKIKNLDRTVSKIVMGNIDPHQRGGKYNSNGENDDDEDYDMNELENDDNENNNKSKNTNMCGVFIKDEEITASRFGMTHSSHSRINFVEKEIPDYKNFKLSLEFKTKEKNGMIWVWANYKSYSRYFYLNIVNGRLQLDVKGHKGLRSFTIPNIKYNDDKWHKVILLRRDRDIFITVDGVTKYVLRDISHPKVMKKRMFVGGVISKHKKLFNITLPGFNGCIKDFEVNGIKYSLDNPESSRDIIPCSVNLNSPSYIHEGGYAAITEPSKYHSVKENSIKFGVDFKTVTSNATIFSIVNPNNPSKERVSVMILNGKLYIDFNFKPYDIVEDLILKADMCHGDWHKLAVEFGEQGTTINIDDKHENIETELPSKLLKMLRDQTIYVGGINPDIKDKIKDYKNFKSITGCMRNLRIGDREVEFHQIKKLNKVISNGCPYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF49</accession>
    <name>A0A0N5CF49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymosin beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF49"/>
    <dbReference type="STRING" id="174720.A0A0N5CF49"/>
    <dbReference type="WBParaSite" id="SPAL_0001648600.1">
        <property type="protein sequence ID" value="SPAL_0001648600.1"/>
        <property type="gene ID" value="SPAL_0001648600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001648600.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16854" checksum="0724E2F666605001" modified="2015-12-09" version="1">MTSTIKDSPKLPTDITNDLLHGRELKHVSTEEKNILPTADDVKVEKQHEEFVNGIEQFSKNQLHKVETADKTILPSAEDIAIEKVPVEVVNFNIDKLNHVEPTVKNVLPNKEQYTREKCLKQAASFDHEKLNHVEPVVKNDIITINDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF62</accession>
    <name>A0A0N5CF62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF62"/>
    <dbReference type="STRING" id="174720.A0A0N5CF62"/>
    <dbReference type="WBParaSite" id="SPAL_0001649900.2">
        <property type="protein sequence ID" value="SPAL_0001649900.2"/>
        <property type="gene ID" value="SPAL_0001649900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF4">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001649900.2"/>
        </source>
    </evidence>
    <sequence length="474" mass="54194" checksum="6A4A31D9BA23D8EF" modified="2015-12-09" version="1">MSFLFDGLQIFTPYLKDDDSEKDETFLNVSFLDGSTKSMRISKKATGAKVCQRVLEYLNIIDTEFFGLMIKHKGRKLEKDNSKESDCCDGTNWEWINEKKKVHQMIPKNAHGLCVFLRVKFFPIDPSKVVDCFSRRLIFLDINEKMKNGVWNFDEYSKSDTIEIIFLAVKAFDPAPIGCNNTQQFIKIAKEYGDILMIKKGISFDDVLRESIRIETSFEKLCRYYENSPVRLFSNINKDTYVLEFLKKVKDTVDYGSFVFDEVGNKCDVSRRVIVNPLGIHIIRGNEEKRIFKGWNSVKSITKKGRNVKISFIKSLDEYDKPCSISFCKKLLDAKNLFTVASGYHKHTNDCLQKIVVEEERMRMSMKSRHASMDSDISSTSNFSSQFSLKNTARNSIVDRLTSIRKRFSSNTANVSLKLRSSPLSSLSSRNMNSANDSGVFNDSIVTSSASNSINLNNSIFETPRRDELLSNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFA9</accession>
    <name>A0A0N5CFA9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001654600.1">
        <property type="protein sequence ID" value="SPAL_0001654600.1"/>
        <property type="gene ID" value="SPAL_0001654600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001654600.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20046" checksum="935B6CCBF5F7E9FB" modified="2015-12-09" version="1">MSKYNFGDSKLIDNLNISATSKSFTNSSTNLTVATPKSTNDVNEQKNEDLSEIIDMFNNGSTPRPETPEEKKAREEMEAKDKKERETIRIAAEDFYNDEKVYYTCYNNFTEYFNKSYIFVNATITDRIYNKTTKHYDVKLNITALSVGNPTDYKDAHGDFNCNNPGMKCNCTITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG42</accession>
    <name>A0A0N5CG42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CR1-gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG42"/>
    <dbReference type="WBParaSite" id="SPAL_0001682100.1">
        <property type="protein sequence ID" value="SPAL_0001682100.1"/>
        <property type="gene ID" value="SPAL_0001682100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896053" evidence="2">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001682100.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25579" checksum="D32E719AD396CCA2" modified="2015-12-09" version="1">MFIYNFILFLFILININLLVESESNDSVKPNNTYFFDLYNIYVLEHSAKDLWKCDDKVTIFIEKEIYVTSATCSKSSNIITLTCDSHKDAYQFVWLPSNTIKTFKIQMSVGNESFTGTFDGNMTNLMSPQIVLINPTNVNETKTVNSTDIEDNSFNAYIVFMIAPTNTILDKSLVKLSYINVILGIVIALAIITSLVILGFTIWKLAQNNPKWMEEQEFALKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGH6</accession>
    <name>A0A0N5CGH6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGH6"/>
    <dbReference type="WBParaSite" id="SPAL_0001695200.1">
        <property type="protein sequence ID" value="SPAL_0001695200.1"/>
        <property type="gene ID" value="SPAL_0001695200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895843" evidence="2">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001695200.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7864" checksum="555A2B998A94E216" modified="2015-12-09" version="1">MHFMKYLAFLFLLAFQNSFQELYGVGEPEEQGLGPVNRYKVEDGPSYDEQTPYERAQERVPSFFALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGW4</accession>
    <name>A0A0N5CGW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGW4"/>
    <dbReference type="WBParaSite" id="SPAL_0001708900.1">
        <property type="protein sequence ID" value="SPAL_0001708900.1"/>
        <property type="gene ID" value="SPAL_0001708900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF3">
        <property type="entry name" value="I-BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001708900.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="30443" checksum="3A9D0AE99F4E8510" modified="2015-12-09" version="1">MKGIKKPSGNVIDKYVKAISILKLAPEFFKHYPINAARNIARIGKRTRLFLSGDIENYSSFNYESRVSRLAEKKILNNKENNLVLVHRRFEILESVPVPKLKSELYELYKDKKAFVFHWFFYRQGHKIAGLDEWFNTEENLNEVSISWTTSYKNRNWEPQFVGDDRVPFHDERFSYRTRSNTHLGHIMCFQNFSFAIMNDVFTVHRGVKRKLNKYESHQLHTSKKLFYEIIYKFNRNLTRLYPNMKHKCKALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHT2</accession>
    <name>A0A0N5CHT2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHT2"/>
    <dbReference type="STRING" id="174720.A0A0N5CHT2"/>
    <dbReference type="ESTHER" id="strea-a0a0n5cht2">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001739600.1">
        <property type="protein sequence ID" value="SPAL_0001739600.1"/>
        <property type="gene ID" value="SPAL_0001739600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="7"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001739600.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61438" checksum="6844D38242188A8E" modified="2015-12-09" version="1">MEFPDGNVTEYLGIPFAYPPMGLYRFRGPVELEKPAWNGTLDAVKLAKHCIQPTQRINFTEYDDMNSKNLTSEDCLQLNIWVPQNSSGDVIVFIFGGDYNSGSPSLDIYNGSILALRTQSIIVNLNYRLGIFGFGYLGENSEVRGNMGLLDQQLGLKWVHENIYAFGGDPSKVTLFGENAGGASVTAHLFSNASHPFFSKAIIISGVISNVWATVSEDIAEANTRNVSAILKCNGTDTEILKCLQEVNATTLLNASLAVSNPKQLPLNIPFLPIQNDTVFFSGNVEKKIFKRDMKKDADMLVGITSDEANNFMHLILEKYNCSFDLSKDISSIENQCLLDDNIFKGVVEMISNMIDFNEQETKSLYDVYSEMRTNATKGKIYELLRDFLFDCTIASFAQRYYGLTNKKVYFYDFKHSLPINLMQEFMEPMFGQDLIYIFGYPFRHPEKYTNEELEKEKKFSEKLMEHIRKFVRFGDLDETWQEFKSNSTKALVINEHFLETSDRKYVHALSRTCKSFDKIISSFVSRNVKDFAENQGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI09</accession>
    <name>A0A0N5CI09_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 81 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carnitine deficiency-associated protein expressed in ventricle 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the IFT81 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI09"/>
    <dbReference type="STRING" id="174720.A0A0N5CI09"/>
    <dbReference type="WBParaSite" id="SPAL_0001747100.1">
        <property type="protein sequence ID" value="SPAL_0001747100.1"/>
        <property type="gene ID" value="SPAL_0001747100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.70:FF:000001">
        <property type="entry name" value="Intraflagellar transport protein 81 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="17">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="278"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="542"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001747100.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="74113" checksum="8C101F563B6F98AF" modified="2015-12-09" version="1">MSVEHIRTLVNYLNNPPFSKNLNLITLDSLRNDKLLQLLSDVLQWITNNNFVDIRSESAEETALRIFNILRLIRFKAPKDLDELHEWRTGIIEGEKGFVYPILYWIFTNEEKIKERVYLSQYLTKVNVPPEFRDDEIIKLENEVSDVMEQFKDIHKAVKEVKGDSLLIQDIKNDLNTMNQEKEQLSRRVEKVKNKVMNIKNYGKYLELAKQLREAKDEGLKYRALKQEQETFIANYSGKKKRLQKDISEIENNINNLDPSQLIKELEEELNSYTYILKEKLHSEIENKQRVISDLTQIANMKAITKEDILQMNNNIENLNNEIMNLTLERDNKDEANDDKLSIYRHQAANMTRKKSVTAEVLQKRREELAELEGELEEKRERLKKKSGDEEIVSSGEMKKYISKFRNKSFEYKKRKANLDNIKREIGILGRTFAILDREWNDVKKEKEKNNEIVIETILKHPEKSKGYERPKTGKVKSRDVNELKDFINGIKNEITEKNDKIKGLNNELLSIHEKINKIKKISQERNNNNDLMEINKFEGMLQKIISEIQEESKNVERHEEYVNKSENNLLLPSLENEQKTIEEEFKVVTKELDDLRKQEHSIDQVEMWKGIQAIFDSKLSSLEKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIC2</accession>
    <name>A0A0N5CIC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIC2"/>
    <dbReference type="WBParaSite" id="SPAL_0001757600.1">
        <property type="protein sequence ID" value="SPAL_0001757600.1"/>
        <property type="gene ID" value="SPAL_0001757600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001757600.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20165" checksum="B405CD498BC41070" modified="2015-12-09" version="1">MLKTIKNNYDAQLISNSATLTRQTIDAISEDCMVKSNIVVRCSSFKFNHIYYKIRNEDFISFTEYADGLVNLPHAEKTKNKEAWEFSDYGILLTVPSNLIGVNFKGCDVMIFHKISVSLSDLYQDFGRLARDLDIGIGIIYITRSSINNHINISTRKIKSIADTAEYWSDDDIDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2J6</accession>
    <name>A0A0N5B2J6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2J6"/>
    <dbReference type="WBParaSite" id="SPAL_0000030300.1">
        <property type="protein sequence ID" value="SPAL_0000030300.1"/>
        <property type="gene ID" value="SPAL_0000030300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023252">
        <property type="entry name" value="Aurora_borealis_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15280">
        <property type="entry name" value="BORA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000030300.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37910" checksum="0061F00644085A86" modified="2015-12-09" version="1">MESTSCCNQSNCISTTSNYSKFSNLLLSPFTSIKSSTPVKSRRISRVVTPLRRSILRSHSCSCTNNPFSPGIYDGSFGLHLNGNDFSPRMFEYKPEDVGNENTFAWNIDQMSKLHPISISEESVCCHSSPNITRHLELREKVVKYFQENHHIPSPDTSRCLGHSKELAKTPLTSKRLRTPKTSITLSSSRSICIYRSLSESSSGNISQSLDSDKRTPKLSEKILEMIQSPSFIGSQKPPEENGNSSDMFVYFPDEDPEYDKEVPLSDEGYYIPVIKAGEFLDTDDSFLQLEEGENDYSHQKVDFDISSIEYDSFRLDLMMSPIPSNSETNLNSPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B322</accession>
    <name>A0A0N5B322_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">REPA_OB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B322"/>
    <dbReference type="STRING" id="174720.A0A0N5B322"/>
    <dbReference type="WBParaSite" id="SPAL_0000047300.1">
        <property type="protein sequence ID" value="SPAL_0000047300.1"/>
        <property type="gene ID" value="SPAL_0000047300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="2">
        <location>
            <begin position="198"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000047300.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36725" checksum="25C05767A9588A32" modified="2015-12-09" version="1">MDTKQINIKLVTRNGNNDQLPFFSLTDLKTSIEIHSNVLEKDICKVILDKYGLECLHHETEAYIDAEDSQIINYANFFQDQQVNVDKLYYLLGSSLTIVVHAHGELTDFFEMGGRSQHLSPDQNSTTAIRSLNIRLGLSYNIKGTNSSVKLADRRLNDTQHPYEIKTIGDTEIRLVETTRTSPQRKLVFTILSNIKRNVNKCVNVVAIIKNIEKATNYITRNGSLTRRRYVYIMDKSVSSVKVTVFGDFCNNFTSDLIGKAVLLKIFRVNQFGALFTITCTMDSEIVLSGKSKLRQLQIWYNNYRNNRANLTNEHELIIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3M3</accession>
    <name>A0A0N5B3M3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3M3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3M3"/>
    <dbReference type="WBParaSite" id="SPAL_0000067700.1">
        <property type="protein sequence ID" value="SPAL_0000067700.1"/>
        <property type="gene ID" value="SPAL_0000067700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893939" evidence="1">
        <location>
            <begin position="21"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="362"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="501"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="635"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000067700.1"/>
        </source>
    </evidence>
    <sequence length="993" mass="114169" checksum="CEF070341225B7CB" modified="2015-12-09" version="1">MERNIFLIFLSLSLINILSASEINEGHCPLVFNVKKYHINEISKVDSYFVNFNITSIDECAKFCGKRHFCRTADYNPIEKSCSISYKETLNCYTNYERFSSYHIDTKRIDKYIYRISCANYCDSKFNSNPHSHEKTQEYKDAINSINGNEEFGKYLNKIPEIILELQRKLGSDTKIHTQLIPVERKIEEKIREIDHKNGSLTRQVQKVETEIKEVKGQLIKMGQLDGEIEEKVKGIIEYVEKDNDKEVNVLSDNLSKSFDNDIVNKIPTMKSFRVVSDDVPLPIQRYPKMRGVRTEVRGDSITFDLPNEPVVINGRVVGYQEKSDKDGNSVDVFYNSKEYNSHEFTYSSKENIDANNAVEYCYRVINEQELMYAGYKTLEQISLNECRCACAESWLTMNDPVCLSIQYFKETSKCILNKGDHHGRYDLVYNPKTVYYHTSCTREVFLSTVKSICNFTLGSPKDTTTLAPINDNNSNVKSDKDEKEEVDSIMVSSKKTSDECFEVIPGYNMIGVTGGMESNVTLEECKCFCAHGKTLNRHKFQCLSATYFHDQRDCLLNIADKEIKPKGFVKNYAKNYRVSYIGMTCPFSKYLTDVFEDFNLHKCRIDDYEERKNNNNNSEEEEVLDVKTKNTDDCFTEMPSYVLEGTAMALETNVTIDECKCYCIDSENRYGIICQSLQYYYDSSTCLLNNENKDSNPEKFSHNRLSDTSHSYFHFSCHSQKIFLSSYVEQTCTNILDQKLPKVELKDEMNKKVDGDLSQDSRLSYSDINKHDKEDKIIQLISNDEIKKHVITSTPNNYLASDNKMINKEESKVPKTSNKPVLETFTQSPNNGNDNANYEENEKTFENNEIDLDDSEEDDNEITTTTTEYPLTTVGDSSETEITTTTGTDEESLTKPLDNIGPCSYNALYNRLFNGNKLIKRVEVDSAVQCFKYCHINNCRSANLMLSTGSGRICELYKDSIVDYRRSDILEFARGGAHFDTIKCQVKEKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4U2</accession>
    <name>A0A0N5B4U2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="9">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4U2"/>
    <dbReference type="STRING" id="174720.A0A0N5B4U2"/>
    <dbReference type="WBParaSite" id="SPAL_0000109100.1">
        <property type="protein sequence ID" value="SPAL_0000109100.1"/>
        <property type="gene ID" value="SPAL_0000109100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="11">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="10">
        <location>
            <begin position="365"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000109100.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61767" checksum="F3E7794165F35317" modified="2015-12-09" version="1">MNIKDTSSVVSSFNGSNILITGFSGFLGKVLVEKLLYDCNGIEGIYCLIRVKRGQKPNERLEELIKGNLFTRIRAKNPSILNKIHVIEGDLLQPNLGMSNETIEFLQEKISIVFHCAATVKFDDILRVSLTMNLIGTHKLVEICKKMKNLKCIVHASTAYANCQLNETTEDVYPSPVDPEQLISALNWMDDDMLEMVTPRLLNQRPNTYTFTKALAETQFIREAKNLPAIIVRPSIIGACWKEPNPGWIDNYNGATGILFAVGKGAIRVMPGDISCKADIIPVDIVSNMMIVCAHYRMNMVTNEIPVFHCTSGELNPLKWKFIVEYCNQCLTEYPMKDPVRIPYCIMTTNQFIFLLDFYLRCYGPAKIKDLFSSFFGKKQNNVRIYDRVYKMIRTLEFFTTNDWNFKSEGLVSLWNTLSKHDQELFNFDIRQVSWSNYLFDYLIGIRIYLMKETVSDVKQSAEKSKSLWKRNFFYSFIFWGLVVKLTASKASSKIKLFLWIFGILAHVIARKYFVSKKHTICTIDQFEKRNTKFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5L9</accession>
    <name>A0A0N5B5L9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5L9"/>
    <dbReference type="STRING" id="174720.A0A0N5B5L9"/>
    <dbReference type="ESTHER" id="strea-a0a0n5b5l9">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000136300.1">
        <property type="protein sequence ID" value="SPAL_0000136300.1"/>
        <property type="gene ID" value="SPAL_0000136300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="5"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000136300.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="64150" checksum="ABE4A7D854651498" modified="2015-12-09" version="1">IKHPSVTEFLGIPFAQPPVGILRFKAPKPLKKNYYGKKCFKATTLANTCYFNRESTGFKGIDDWQPQSLKMSEDCLQLNMWVPTNKTGAVIIFINGKSYRMGSPSLKFYDGNMLASFNGTIVVNINYRHGVLGFAYMLGGYLVPGNMGLLDQQMAIKWVYDNIESFGGNKSMITLFGHGTGSSSATAHMFSEGSKPYFSRIVAASGTILNKWAIEYNKENVDENFRRLMRRLRCFTRNELNLLRCMQRQRVLKLVIEADKIFNLKQTIIKYPFLPIDGDNLFFNGFIVKMLRYGFFKKDLDIVIGKIYDEASVFMPLYFSKKNYGFNLNLNKSMNSQANKCNIDSRQYENIVRLIARDQQLHRDAVDEIIFYYSGLKELNYRDKAIRIVSDFGFDCDFARFARKIGRYITGNKYLYEFEIRSTQTPFPFWMGLVHGYELLYFFGHPFTNSLEYKKEDLMYEKYFSFHAMEMLSMFVNKGKLHDNWLQYSNKFMCMAIFDANYKINNKFQIRYANTKECLNVKSIYQYYRIRALRRYRSDYPANKNDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6K4</accession>
    <name>A0A0N5B6K4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6K4"/>
    <dbReference type="WBParaSite" id="SPAL_0000169200.2">
        <property type="protein sequence ID" value="SPAL_0000169200.2"/>
        <property type="gene ID" value="SPAL_0000169200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000169200.2"/>
        </source>
    </evidence>
    <sequence length="203" mass="22986" checksum="EB19E6D13F36C9E4" modified="2015-12-09" version="1">MSCYSNPSIDSCNSCLSIYSDASSFENLDNRPCTKSNYEDTTDSQYTFVSSYLPSLDSCTSCYCSPDELEFLQHSNSTSSITSVNRCKKNTNPRPDIKSLDKSTETLCYDSEATEKMLIKSGLEKNIENFTHNELSLSTKRLPPYLVEHLGNKKIEIIEITDQVDLKIPNCHYYSTIFFIDNGDSISSFVKDFYQSQEIKGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7D9</accession>
    <name>A0A0N5B7D9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7D9"/>
    <dbReference type="WBParaSite" id="SPAL_0000196500.1">
        <property type="protein sequence ID" value="SPAL_0000196500.1"/>
        <property type="gene ID" value="SPAL_0000196500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000196500.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9318" checksum="E22273E84098A5FC" modified="2015-12-09" version="1">MFNVPQQYEEFLSLPTKMFNVPQQYEEFLSFSSNSKPDLKILTNYGRPRLDSLSSTMPKVTFVSRPIKQSSRGLTSLRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7F7</accession>
    <name>A0A0N5B7F7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7F7"/>
    <dbReference type="WBParaSite" id="SPAL_0000198300.1">
        <property type="protein sequence ID" value="SPAL_0000198300.1"/>
        <property type="gene ID" value="SPAL_0000198300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894005" evidence="1">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000198300.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10203" checksum="4EA681AD9EAA6125" modified="2015-12-09" version="1">MNKFSFYIFLFITIILLVTHGANGRSLDDNHVKIGEIQPDYNEDPRYIVVKNHYKRERPLQMSGYGWDECEFSPLSCLLKKRNYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M3</accession>
    <name>A0A0N5B7M3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7M3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7M3"/>
    <dbReference type="WBParaSite" id="SPAL_0000204800.1">
        <property type="protein sequence ID" value="SPAL_0000204800.1"/>
        <property type="gene ID" value="SPAL_0000204800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000204800.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18323" checksum="DD43BB42D951691E" modified="2015-12-09" version="1">MAMQYPYLGKESLEEKEKEKLGTEVVKKLTNNYIGDHRTVYMDSFFSDFDLSQYLLQNKMYSVGTCNSNRRFIPTTFKKNSRKRDIGAVYVYHDQMTLVNFKEKKNRNAVNVISTKHIGLQKEEVLPNIVKNYRKYMGGVDRFDQLCGNYTVQRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9F4</accession>
    <name>A0A0N5B9F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TFIIS-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9F4"/>
    <dbReference type="WBParaSite" id="SPAL_0000267000.1">
        <property type="protein sequence ID" value="SPAL_0000267000.1"/>
        <property type="gene ID" value="SPAL_0000267000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000267000.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23673" checksum="72DDF1DA7B281286" modified="2015-12-09" version="1">MIPEIEGEKDHNECHPPDEVYNDIDLSFDNKVPEVMYENELYEEYQIYVDEGGKEYIYMNGEPILLEEANDVIYEEAIQDYDDEQAYHYFKETQFIDPPIIVGGNKRKRKKQCKNQNKSKTRETAYDNMKIVDRKTCSQQKLTELIDKNSTNIKCLSCNMEYFITKQLYGKYKVVVEKDDEGGSIFNFVCPVCSIRTTCALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9G6</accession>
    <name>A0A0N5B9G6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9G6"/>
    <dbReference type="WBParaSite" id="SPAL_0000268200.1">
        <property type="protein sequence ID" value="SPAL_0000268200.1"/>
        <property type="gene ID" value="SPAL_0000268200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894140" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000268200.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9241" checksum="BAF32C5D98E272BE" modified="2015-12-09" version="1">MNIYSFILLAVLFSITTGRIIHKRQTFYYDPDLKKYAQTHAGTKYSHGTASLYGPEEWGKWYARTMMRWGGLSHFVPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Q4</accession>
    <name>A0A0N5B9Q4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Q4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Q4"/>
    <dbReference type="WBParaSite" id="SPAL_0000277000.1">
        <property type="protein sequence ID" value="SPAL_0000277000.1"/>
        <property type="gene ID" value="SPAL_0000277000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000277000.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39403" checksum="43066F6EBBB30CF8" modified="2015-12-09" version="1">MNAIKPSASYITETSWFQPNYIVDFKYHIHSLISTGGFGQVYWASDNYTGQFVAIKVEKKDAKYQLLKFEAETLSKLNKISYKRHGKGKKFDCIKLINYFETKNFNFMVMPLCGPNFYEIRKAMIEEKFSITTTLWVMKNMISCLEGLHNYGWIHRDVKPANFCIDLYNTNDCRRKMYLVDFGLAKKFRKSDGSMIPKKDYSNFKGTVRYTSINSHRRRDLGRIDDLWSVYFICVENLIGSLPWRNIADKEEIGYMKKECNLLELNYGSTGPPNSFKVLYEQLRSTGFYNEPKYGELYDAIENEMRDFGYYSHGKLLDWEECGIINLILFQKGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9X9</accession>
    <name>A0A0N5B9X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-complex protein 1 subunit zeta-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9X9"/>
    <dbReference type="STRING" id="174720.A0A0N5B9X9"/>
    <dbReference type="WBParaSite" id="SPAL_0000284900.1">
        <property type="protein sequence ID" value="SPAL_0000284900.1"/>
        <property type="gene ID" value="SPAL_0000284900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000284900.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="58913" checksum="E77A9F59EF1D1922" modified="2015-12-09" version="1">MSSLQCLNPRAEMARQTAALELNMTGAKGLQKVMQSNLGPSGTLKMLVSGAGDVKLTKDGNTLLHEMQITHPTASLIAKTCTAQHDVAGDGITSTVLLIGELLKQADKYVSDGVHPRLISEGFEKAKVLALEFLEQFKESPEINRDLLVEVARGALRTKLRRRSADHLAECIVDAFLAIKDSDNLTEPDLHMIEIMEMLHENDTDSKFISGLVLDHGGRHPDMPKHVKNAFILTCNVSLEFEKTEVNSSLFYKTAEEREKLLQCERDYITQRCQKIVDLKNQVCKNGEGFVVINQKGIDPPCLDLLAKNGILALRRAKRRNMERLQLACGGEAINAIENLDASVLGYAGTVYEHILGEDKFTFIEDCKSPKSVTLLLKGPNRHSIIQQKDAIKNGLRAIRNVYNDKCVVPGAGSFEVSCHVHLMEKCDTIEGRERLGVQAFAEALLVIPKVLAINAGHDGVKSIISLIEARKKRGVVVGVDLENGKPIVPSGIWDNYIVKFNALNACTSIASNLLLVDEVVRAGLSNLKGDRLDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAA1</accession>
    <name>A0A0N5BAA1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAA1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAA1"/>
    <dbReference type="WBParaSite" id="SPAL_0000297100.1">
        <property type="protein sequence ID" value="SPAL_0000297100.1"/>
        <property type="gene ID" value="SPAL_0000297100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="89"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000297100.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43682" checksum="906B0694327668F6" modified="2015-12-09" version="1">MSIEPQEVTNDLHDCETAHIPEDLEGFEEIHCSQQNFGINNINTENEKYSSKCPNMSSNVAYISVQSFSESQFESDFFQTLVYSHLPHHYLGELIGEGGFGRVYEVHSFKSKKKYAVKMVKTKSSFLLEYKLIMKTMMISQEYFCKLYMAYCKSDGAFLVLSLEGSDLKSVMVSLPKKKFSTHTLLRLALQMLLAIEAFHQTGYVHQDIKLANFVLSNDSRSRIKMIDFGIAKKYKNSRGEIIPEDKYQKPKNYVGTLNYCSLRVHNLYHSSPRDDVESWLYCVIQTVDGKLPWHKQSNGDQNIIAKMKHDIRLWSREELKQHKFHAFHKLFAIIDKWEYYDKVDYEYLKEFLKKLMVSNNIDYDLKYDWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAJ1</accession>
    <name>A0A0N5BAJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000305800.1">
        <property type="protein sequence ID" value="SPAL_0000305800.1"/>
        <property type="gene ID" value="SPAL_0000305800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000038">
        <property type="entry name" value="Glutamate-gated chloride channel alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="216"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000305800.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43656" checksum="10168B9EE9893A8E" modified="2015-12-09" version="1">MNKESYNSRVRPDFKVNKDAVEVDVDLFIRSISNLNEINMEYLSQITLRQKWVDERLAYGNNKSILNPPEYFILNDDSKIWMVDTFFPNEKSAHRHMIDKPNMLLRVYGNGSIIYSVRLSLVLSCPMYLQYYPMDVQNCYIDLASYGYTKEDIEYKWNDEAPIQFRKGLTKSLPQFEIINYTTTTCESVTKLGNFSCLRFKFSLKRQIGYYLLHLFIPSILLVMVSWISFYLDPNAVPGRVTLGTVTLLTLIANANGINSKLPPVSYIKAIDIWILFCVVFLFTALVEFAITCFLYNRKPTYTLVDKTERNHSNIEDREGNSYNCRMKFFDRFSGNNAKQIECMSRMVFPICFLLFNVFFWTYYSEQRYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAY6</accession>
    <name>A0A0N5BAY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BAY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000320000.1">
        <property type="protein sequence ID" value="SPAL_0000320000.1"/>
        <property type="gene ID" value="SPAL_0000320000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000320000.1"/>
        </source>
    </evidence>
    <sequence length="3327" mass="362612" checksum="0A6108A705E1F01B" modified="2015-12-09" version="1">MESKLGLNCTNSSQCTGIGEYCSSYNICLCLTSHVEVSSTCLPIIFPGNSKCLSSLQCTNGFPGSWCDKNHTCQCPDGSIIKGNTCILATNGIPLIQADNSVVTNTVNLAKSSFFDKITDFIALKTRSIFSNQQSETNEIIGVRPGGSCINDLACAGYPLAYCDTVCKCKENSYNAGSTCITLPTATQNNQGLCPSDQVYATEPGICVNRVFPGNNCQYSEQCSAIESGSFCRNNICECVFGMIKSNDGRRCIFRDNHCPTKGTIWVPELGECKQVIIPGVDQCSHSLQCSTAFNGSYCYERKCTCPDSAPVPVDGTCGTDCQEGQSFSSITGSCLPNVTPGYECTYTSQCHSSFPGTLCIAGICKCGKNKVFTGTRCDYTCPSGFMKGAHDICVPGCTESQIEHNGECLPYASPGQDCKVNAQCLGDSLCGNGICTCRPNMQIVGGVCQVIKVFPDQSCALGEECIGGSYCVDGTCLCGPGTVNVNNQCIKPITVPPNSACTKATFCSGGSHCINEICTCEFPLVPINNTCSYPPSVLPKHPCPTGYEKCLGGSTCIQSICTCPVGTVEEGGNCHAVIYVNATQACSISRICTGHSVCIDHVCTCPNPYILKNGVCMLLGIALAGHSCANNQPCTDNAYCDQEKKICTCIPPTNNQNGICILSLTSSPGGPCDETYVCTGFSNCIDNICTCPPGTINIDGICKQILVDFGNCTNTTDCPDNSYCDEVTKKCLCPNNTIPVDNKCISLNEKPLTGTNNSSVSYNDQKTTRNNSQIELGQNNNNNTQVPPGGSCIESFYKCINGADCVAGTCICPPDTRLINGKCTKELFAFPGEDCGSGQECTRNSVCNHETLKCECINTSKIAIGRSCVDRLRSYPGYPCGNGEICISGSVCYKGVCKCPGNQIVSNKMCVEPRRLMPGNKCSDDDICTGNSECDRKTMMCQCRPHHIAIGGICTRIILSKPGEKCLGQQYRCILNSYCNGDTCVCLQGMKLIEGQCKIPLKKQPGSFCTEYDECTNMSTCIKGRCTCTPPRILKNFKCEIPVEVRAGESCNYHDVCLGGSSCVNGRCLCNPNEYIRSGICTEKVSKKPGEHCNDYEICGGGSYCNRSKYCTCNVGYAIEDSKCVRKTRSNPGESCKSGERCLGNSTCLRDICTCPKSTTLSGKNCIPVRDANIGESCAHGETCLSGSKCEPRSKICACPPGYVNRNAFCVPIEGLMHKKKSQESEYFHYPDRIKNSYSFAMNKESLKRNDFVSPSHCNKTSDCDENAKCKNNICVCNPNYVLKNGFCIRIISAVAPPSGGSLGHKCSTSNDCHVNNSQCKNGRCLCAPGFKMLGVNQCIKGAFSKISRSEPIKHYEEISLPSSRRPSIPGGKCVDSKECLNRSFCHQGKCVCPRGMKTIKNHCIEVEIVPPLSTCNDGQICAGNSECSVNGICLCPQNHTLYKGFCQTDEQIEIMKKILGSELDKKKGLVAIPNLKIIEKMSLLEKIELMASKAKVIQNTTTEIPETTKKFITTLKPRKPTKLPLDEIIKNASREKEMIKKLEKIIYQTRKTTTSIKETSPTTIPTPKITITTKTTESHTTTQKKESLKTTQRIKSPKTTQKIESPKTTLTTELQTTSTTKVSVESSTMIPTKVSEIITSPTTLLTTTSPVTTDITQSSKKATKTTLLTTTSPVTTAITQFSKKAPKTTLIATQQILSSTSTTSSVITTTMPTTIPTSKTTKIESPTTSLPTTESFKTTLIPPIDRKINIIPTSPDYNPKTMKPINITNIIENKVKSNKIIEKNDTMTIQVTELPTKKTTSEPIFTKQPEIIPSTNNTLPKINQTITNNLNITTILKELLSIKEPFIVSSTQPTIEENYVEVEEVGEIDENGDILPVLQILPPYQPSSNNNFYKTFPNLISNTQYSSALNSRPLKIPYSLFQISYPGQFCDEALVFCSGNSTCEQNTCQCNENFYLYNNECLPIDMNVNCISNDDCPLVNPGSSCSNGETCIGGSYCKNNICICPQDKQFIVDNTCSPTPTPQTVPVEESELKNSTESYTTTKINYLNLTKDIETNPISRVKRDAMIGLGYECTNITLNNMTISPCIQNAFCLEGFCQCSYDFLQAGNACYPKNLIGNVIKEPGEDCETYYYCNGGSTCNPNTKKCECNTGTILYNSHCVRKNVVGEGSPCNETQECGPGLECIDGICVDVTQPINATVVEVGPGQPCPKSDRYIICKCTGNSILANNYCICPGGEKIIDGVCVGVDSVADPGESCVSNFTICLGNSNCLDNICTCNEGFINVNKQCIPSSSINTTTTTTTPTITTTTTITTTTITTTTISTTTTIYIPGIGEPCTSVIGCRNGAICLNRICQCPPNTILVNGQCVIRYITANPGEPCSSDGIICIGGSACINNICTCPQGSFIVNGKCVLGSLTTPPQPIWRVIDPGFPCGMPFTRCGGGSYCSGGLCICPPNFVPIKNICTEYINVITTTSQPFTPLFPGDVCGMPNSYCTGGSSCIYGFCQCQNGQVPMGTICADVIGQTSTMTPITTLLPGESCDAVCELLRTCQKYCGGGSICIGGVCTCGMGYVAINGICQINKDYSLGNDVKYVADEPSWISSYRYPGQDCNTFTTCTGGSACDGKICQCPTGFVPTKNDRSCINSNYLREISTKTNDIINNNSNTNILVRTPELSSIIKPFKSMKYSGKYKKCYDDTQCEGGMICNTLGLCQCPKQLTNFNGQCIDIYSEKLAYPGSKCISKETGAIKLLTCANGSQCNKKIGYCLCPNGTLPNLSSFCVTADHVDSKLALPGKGCDKNITPNCVNNAICQDDFCVCPYGTKNNGNGVCSSRVTLDEGIVLREFNKKLINDPCNNTMECIFPGECKKGICSCPPEMKVSDERTCLNKKKLSRIGEYCDEVAGIYCINNSACIKHYCTCKEHFIPIRINNELEYLVINTDYVNFQSDIDDDEPFILRPIEDSLLECPHDGTCSLPDCFCSRTGLNIPGNLRYDETPQMVLLTFDGPITDRVINIYKNIFSGKHKNKNGCPIKGTFFVSHEFNNYDQTQWLYSRGHEIAVNSITHRSLSDLSEEEWKDEMVGLREALQKFSYIDSRKIKGLRAPQFALGGEGQFSMMEKENFMYDNTQTTLDGPYWPQSLHYKTPWRCVRQNCPNTSHNVWEFPINMLTRNDGKQALFMLQAVTRFDSPDQIANMLIRNMERNLKSNKAPFILNIESDFLTAIPFNGALKALDIFITKVLQRNDTYIVTMEEALIWIQRPTKLSKLKDFFPWQCRRYRNEYQRPCETPSICSYTDGPTSYPHSFRVCGSCPHVYPWLKDPIGRGNTFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBH1</accession>
    <name>A0A0N5BBH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein Asterix</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBH1"/>
    <dbReference type="STRING" id="174720.A0A0N5BBH1"/>
    <dbReference type="WBParaSite" id="SPAL_0000338000.1">
        <property type="protein sequence ID" value="SPAL_0000338000.1"/>
        <property type="gene ID" value="SPAL_0000338000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000338000.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12477" checksum="3385B96A2200744D" modified="2015-12-09" version="1">MKKNHYSSELKNASKIIRYKPVIQNLAVLASEDPMPEYMNMLGMIFSVCGLMFRMKFCSWLALLSSCVCFANSRSSDDTRQIVSSFMLSISAVVMSYLQNPAPIEAFWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC09</accession>
    <name>A0A0N5BC09_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC09"/>
    <dbReference type="STRING" id="174720.A0A0N5BC09"/>
    <dbReference type="WBParaSite" id="SPAL_0000355900.1">
        <property type="protein sequence ID" value="SPAL_0000355900.1"/>
        <property type="gene ID" value="SPAL_0000355900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000355900.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52890" checksum="FDC260EE13584DFF" modified="2015-12-09" version="1">MYLDDLPMWNPVGEFVTGTPNEHYLYTHRKFEIGYNGNRIVDVNVTQGEKVLIRPNMVVEFSYEVYWLNSDITFDRRFEKYLDPGFFQHRIHWFSVFNSFMMVIFLVGLVGMILMRTLRKDYTRYHNADELSDDKDFGDDYGWKQVRGDVFRSPSMPTLFSSLLGSGCHIAAVVFIIVCHSLYEEMYTERGSFMSAIIFYYTVLSPINGYVGASYYYKFGGKKWIRQIVIGTGLFPCSVSCVALAINFVAIYYHASRAIPFTSMLTVIVICLFVILPLSFIGACIGRHFNREISHPCRINVVPRPIPDKKWYFEPFSLIVASGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMLLVIIILAVVTTCSTIVSIYCLLNAEDYRWAWTSFFAGASVSGYVYLYAIYYFIAKTKMYGFFQTTFYFGYMGLFSLAIGLMCGTIGYIGASKFIHKIYSAIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCD8</accession>
    <name>A0A0N5BCD8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Clc family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCD8"/>
    <dbReference type="STRING" id="174720.A0A0N5BCD8"/>
    <dbReference type="WBParaSite" id="SPAL_0000368700.1">
        <property type="protein sequence ID" value="SPAL_0000368700.1"/>
        <property type="gene ID" value="SPAL_0000368700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000042">
        <property type="entry name" value="Clc-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF54">
        <property type="entry name" value="CLC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000368700.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32442" checksum="CC8E9D3A870F320D" modified="2015-12-09" version="1">MSQSKFSCTLLVPSVILSIIGLILCFIGVITPSWQVVYARELQQTIQSGLWINCQTRPSGMYTCTYTFSESDYNFYTSAELVNFRTPPFYSWQRKLLYTILVGQFIGVVGLFSFCTSFYQPVARKCGVIYAVLIGISAVMNLTTSVIFTIFAHMVEYRFFHVSVSGIYEKHKGYSFYLHLVGGILLFISLIIAIIHVVIQFKNKQIERVDDYDRDYMHYGKNVFHEYQYYNNPQGNTLQQPPQRYHGYADSFTGSGSWHGSQDFRMHEYDHIPRYNQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCH2</accession>
    <name>A0A0N5BCH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCH2"/>
    <dbReference type="WBParaSite" id="SPAL_0000371900.1">
        <property type="protein sequence ID" value="SPAL_0000371900.1"/>
        <property type="gene ID" value="SPAL_0000371900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000371900.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15385" checksum="823EAD3151488463" modified="2015-12-09" version="1">MQGDEIMDIFAYPFRHSKRYDKKALKNEQKYSKTLILLIREFSKSGHPSKRWAKFKDPNTTAFVFNGKLDLKKSLKQKDVLPLCSKVNCIIINTRRKLQNEVIVTTTTQATTTTKKKSVFDKIKVRFKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCS8</accession>
    <name>A0A0N5BCS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCS8"/>
    <dbReference type="STRING" id="174720.A0A0N5BCS8"/>
    <dbReference type="WBParaSite" id="SPAL_0000382300.1">
        <property type="protein sequence ID" value="SPAL_0000382300.1"/>
        <property type="gene ID" value="SPAL_0000382300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382300.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49757" checksum="F491A664446BBCED" modified="2015-12-09" version="1">MTCPCIKLLIDNVKKLWKQRTRYDNISDFQTIENFEARWSCIFVEYVLENVHCVGKSCLNKGDDMVWYVPMANKACGGKDPSATGTSYLQVFRKQSKNKPIPGSSTINWEETVCLNILMQFVDFYVTCAVCTKNSPNNLQIQRKNCQRVYPSPSRRRMDAKGESEEITYPRIYFAIDNFEQVFSDMIVTPGECVCVELVARTRYKENESVIFLGSIRYEVLKQTYENKATKTWGWAQKLMNANKKRHEFIRMRGPHGKGFAEMAIARIASCGFETPMSEYGYDMRRSLGDTDRNSERRMSDTNLFNRMLTKRTAATPTATPTTTSFFGSLGNRARRWTSEADNVNQNNEVEAKPIDEEVNGLGSLNRLWPMKSINSAVSWLQKTDEEMPLNSYLTFITLQWNNILEDLLSDRPKKPILTFELDGFYQPTPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD06</accession>
    <name>A0A0N5BD06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD06"/>
    <dbReference type="WBParaSite" id="SPAL_0000389900.1">
        <property type="protein sequence ID" value="SPAL_0000389900.1"/>
        <property type="gene ID" value="SPAL_0000389900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894183" evidence="2">
        <location>
            <begin position="25"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="346"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000389900.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="64791" checksum="4237A79132DF2D0D" modified="2015-12-09" version="1">MKFLWLVFNFYLLTVLLVREGSSAGAGNKWSGENELEDVSEGLKEYLNANKYQCTENLDFYTFTCSKWAENEKKKERIVPDMAINYRNIMFQKFIKSTLNIKTINETKLVKDSLNINTSEKRGLLADLSSIKIIRTDYWLKDLGFSEKNRNSTTTNETVLLDDKMDIRINNRSYLLEEFSVFYHECNKLKSKKEIFKCQQKVLKIGYPIYFSQFLKENRFSNEVTNKFKVVEKIAKNIREEFKRLIMNKWFIKSNEAAMMIKKIDNMKFRYGYSYEALFNDIQIEECYNDLLLNSTTGYKRTVFEVIGNYTYLAETLTKNVPRECKFIYENDEYPVDPFDLLFSRYVPEINEFVIHHHVLNEPKFSTKYPESLNYGGVGFEIARQIAMAFVGNNTFRDYNGILASEMFSTKFKHQHEVSTSCFMQKYGEEFSKGENYRNLRSYPQLNSDIADSIGLKVAHLAYMRYLRSVNGKEPKIPGFEKLSGEELFFMSFSRGLCEDKSNYDTFFQLKDHTISPSSKRVVGALYNYKPFIYAFGCKIVNPIATANECNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEW5</accession>
    <name>A0A0N5BEW5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEW5"/>
    <dbReference type="STRING" id="174720.A0A0N5BEW5"/>
    <dbReference type="WBParaSite" id="SPAL_0000453400.1">
        <property type="protein sequence ID" value="SPAL_0000453400.1"/>
        <property type="gene ID" value="SPAL_0000453400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000453400.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38238" checksum="74580474C7E448AF" modified="2015-12-09" version="1">MVLTCRFYSEKFPDLDEPVMVNVRRIAEMGAYVTLLEYNNIEGMILLSELSRRRIRSVNKLIRIGRSECVVVIRVDKDKGYIDLSKRRVYAKDLLQCEERYSKAKAVNSILRHVAEQLGYGTDEQLEDLYTRTAWYFDDKMKKKAASHGVFKKAISDPTVFDECDITDEEKSKLLEEIRKKLTPQAVKIRSDIEVSCFAYAGIEAVKTALLEGLKHSNDKISIKINLIAAPSFVVTCQTLDKEDGLNAVNACLEAIKKKIEEMQGTFKLVMAPKIVTDLDEDEIKKKLEALELEEDDDESEADDDGLVAPEGLDRAADLQDARDKLSGKKAPQEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFB0</accession>
    <name>A0A0N5BFB0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prion-like-(Q/N-rich) domain-bearing protein 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFB0"/>
    <dbReference type="WBParaSite" id="SPAL_0000467800.1">
        <property type="protein sequence ID" value="SPAL_0000467800.1"/>
        <property type="gene ID" value="SPAL_0000467800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895:SF21">
        <property type="entry name" value="PRION-LIKE-(Q_N-RICH)-DOMAIN-BEARING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895">
        <property type="entry name" value="PROTEIN CBG03177-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894177" evidence="2">
        <location>
            <begin position="23"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000467800.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="67881" checksum="8D1F417ABC5C24BC" modified="2015-12-09" version="1">MKRWNLLFLVVVLTAFCLTVFGDQNKTLENDELSVNKTLTRAKRQCCNSGTQSCCPQQNTCNCAALQIQVQQCDCANIQQNQCGCSSQTSSCNCPALQQQYTQCGCGALTYEVSCNTCQQQQQPQPQVIVVQKPQENTCTPACMPACDNSCVSQAAQQIVVVQSQDNSCPQACRPSCSNQCVQQQTLCVSACESSCATSCQSNNACVSSCQPSCMNSCMEQSQQQIIVIPQQNNQCSNSCNNQCQSSCSGSVQCTQTCNNQCQNACSSGTTAPQVIVVQQQPQTCQSSCSNQCQNSCSGSVQCVQSCNNQCQSACDSGSSAPQVIVVQQQPQQSCQSSCSNQCQNSCSGSVQCVQSCNNQCQSACDSGTTAPQVIVVQQQPQQSCQSSCSNQCQNSCSGSVQCVQSCNNQCQSACDSGTTAPQVIVVQQQQQQQSCQSSCSNQCQNSCSGSVQCVQSCNNQCQSACDSGTTAPQVIVVQQQQSCQSSCSNQCQNSCSGSVQCVQSCNNQCQSACDSGSSAPQVIVVQQQPQQSGCTSCAPQSYGQCVPQCQPSCQPECIKMYTTYVQQPAITACTQSSNGCGCSSGYTQCMQGVCCLRRRHRFARNTKEEPIAEVSENIKSSDIDEKQTEKEEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFZ6</accession>
    <name>A0A0N5BFZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFZ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BFZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000490400.1">
        <property type="protein sequence ID" value="SPAL_0000490400.1"/>
        <property type="gene ID" value="SPAL_0000490400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000490400.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28132" checksum="C699834C43051EE4" modified="2015-12-09" version="1">MSFPAKKYTNAKKEWAGESYIVTPSIFKILVESDLIKNKDVIDIGCGNGNHSNRLLTWGAKSVHGIDQSIDMINEANATYNKDNLTFENLSTFDMKYEEKYDVAVAFFVMEFNPTVDDLFMSLKNIQKCLKKGGKFVAIIPNGTLDYNPTTEEGQKFGASWEVDSSTKRYDGERLKVNFYDKNGEVVGNAPVTFFFKETYTRGALEGGFKKVEYENLIVSEEGTKIYGEEFFYSFTHPPKIIFFIGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGA6</accession>
    <name>A0A0N5BGA6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell division control protein 42 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGA6"/>
    <dbReference type="STRING" id="174720.A0A0N5BGA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000501500.1">
        <property type="protein sequence ID" value="SPAL_0000501500.1"/>
        <property type="gene ID" value="SPAL_0000501500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000167">
        <property type="entry name" value="Cell division control protein 42 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000501500.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21202" checksum="275481C7AEB94D54" modified="2015-12-09" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVIAPASFENIKEKWVPEITHHCARTPFLLVGTQVDLRDDPNVLEKLAKNKQKPISAEMGEKLAKELRAVKYVECSALTQKGLKNVFDESIIAALEPPAPIKKKRCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHE0</accession>
    <name>A0A0N5BHE0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHE0"/>
    <dbReference type="STRING" id="174720.A0A0N5BHE0"/>
    <dbReference type="WBParaSite" id="SPAL_0000538200.1">
        <property type="protein sequence ID" value="SPAL_0000538200.1"/>
        <property type="gene ID" value="SPAL_0000538200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000626">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="82"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="264"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000538200.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54218" checksum="7BD27F884594D891" modified="2015-12-09" version="1">MSDSSDDEIFEKVRPKTNKQGLSKDEEETLKILKAKTKDDGEEGEEVSEPPSFAELGVTDVLCQTIERLGWKAPSKIQEATLPHALAGKDLIGLAETGSGKTGAFAIPILQALLETPQKMFAVVLTPTRELAFQIAEQFQALGTAIGLSVAVIVGGIDMATQAMALAKRPHVIVATPGRLVDHLENTKGFNLKAIKFLVMDEADRILNMDFEVEVNKILRVIPKDRKTYLFSATMTKKVAKLERASLKDPERVEISTRYQTVEKLKQHYIFIPNKYKEAYLVYILNEIASNTAIVFCSTCAGAMKIALMLRQLGFGAVPLHGQMNQGKRLAALNKFKAKQRSILVCTDVASRGLDIPHVDYVLNFDVPTQSKDYVHRVGRTARAGRSGVSITFVTQYDVEVYQRIEHLIGKKLDLYKTNEVDVMKLVERVAEANNSARVEMKELEESKKNKKKRKKGEACDGDDDEEEGGYRKKVKVKNMKTIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHE1</accession>
    <name>A0A0N5BHE1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHE1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHE1"/>
    <dbReference type="WBParaSite" id="SPAL_0000538300.1">
        <property type="protein sequence ID" value="SPAL_0000538300.1"/>
        <property type="gene ID" value="SPAL_0000538300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000538300.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35462" checksum="36CA2A1DC8CDCADA" modified="2015-12-09" version="1">MKLIKNLIIFALVKGGHKFVALNSNFDAFYLIFNSLLNFYYLKQYGSSFFEYFYGIKRVVKNTGTIPTSNAEVARSLLQIVFLPYIKEKVIAWKKKLSEESLVIQSKWKYFLLKSWPYILKAINIISITLQVMYLFGYVPIHNIEMLLAGVFYQKYSALDLKLMESRKLLFDSSNIFGRFINFIIGLFSKFGKILSFVLIGIQVLQYVQESNDGSLNSILNIFKTNSSGERKSDIQFPVKMLDETEALNLSKDQCPLCLKKRENDTVLSSSGYIFCYKCIRQYISKYGRCPVTSTPATLNQLVRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHG5</accession>
    <name>A0A0N5BHG5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHG5"/>
    <dbReference type="WBParaSite" id="SPAL_0000540500.1">
        <property type="protein sequence ID" value="SPAL_0000540500.1"/>
        <property type="gene ID" value="SPAL_0000540500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894279" evidence="2">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000540500.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34953" checksum="89A3F2970775C9E0" modified="2015-12-09" version="1">MRFIKYLTILILLAVQYSFQDSSLENPSSLETPLSAEKSHSSEDLSLAQSELMQNDGESETNLQDTSPLENKEETEGLMKKFEQNLSGEVSNEEEDNSPGISPIADDAVPEVEESMEQNNSNSDKEADDNEADDLTKESPSENSEVPNVDEVNGQPGPNSNDKNDSNEEAISSVELTEVVPEVPETVELIEELGPNSIETVEIKSESNIGRNRFSNGLKKLSNKFGDLLGSGTNKLKNFYKNSKNKLTAFSRNLKNKFSGLFGRKHPKQLAFNDDDSREKRSILKESAKELGSDIKKFANKVGSKIRKLVSRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHJ2</accession>
    <name>A0A0N5BHJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000543150.1">
        <property type="protein sequence ID" value="SPAL_0000543150.1"/>
        <property type="gene ID" value="SPAL_0000543150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000543150.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16407" checksum="BDB405643AA6AA41" modified="2015-12-09" version="1">MTSRKKCSIERVKRSFGQKIKFTTPQKDKINHDERKWYKTKPLTQRIKRVKYSKKKRNGRLLGIVDSGGETFVCHCMTEQQIFLSIDFNTEKAMLDFILSFHLSLVMATSTRISFVTVMILWTDSTFIIDTAQLRQFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHM4</accession>
    <name>A0A0N5BHM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DPY30 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000546200.1">
        <property type="protein sequence ID" value="SPAL_0000546200.1"/>
        <property type="gene ID" value="SPAL_0000546200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000546200.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11663" checksum="6AD4BE986DE812DB" modified="2015-12-09" version="1">MSKTTSLKKLIEDPTDLCSQCIPTDGTTSNKKKELLLFALGLFASIAIKLLSMTTYGKKILEWLCKIEEYFPDTEISDLLRSATAAATTTADTTTTNGDDKEFMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHV3</accession>
    <name>A0A0N5BHV3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHV3"/>
    <dbReference type="STRING" id="174720.A0A0N5BHV3"/>
    <dbReference type="WBParaSite" id="SPAL_0000553800.1">
        <property type="protein sequence ID" value="SPAL_0000553800.1"/>
        <property type="gene ID" value="SPAL_0000553800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000553800.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36890" checksum="5E68F8D4EAB599F1" modified="2015-12-09" version="1">MNGFEKRNRRLNRLKFIFTSFNFLILLSSLFLIGFSVDYFVNEYQSSVMKNDNTIILTSFVFITLAFAIFIFVIFGFFSVITLDKKLLQIYICASLFISLINGIIGCYCFVTNINLSLDNTRAKLSKALSQHYGDDSHKSLTEAWDFYQQQFSCCGVTSEIDYISTQWFKKQQPTLPRKRRPLSCCPSCEQLFSHHCLPKTSQILTTQPTHTQPFIDGSQLHTEECLTILHICSFNSSYPFSDDMCHGNLPIPPGVPISFLLHTNGCLKVIHEKDRRIVEKFIIISWFYSILNAINASFVLFIYQRVFIKHAYSTISLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHZ5</accession>
    <name>A0A0N5BHZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHZ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BHZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000558000.1">
        <property type="protein sequence ID" value="SPAL_0000558000.1"/>
        <property type="gene ID" value="SPAL_0000558000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000558000.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14043" checksum="3862AED16ACC929E" modified="2015-12-09" version="1">MTSRNTKKTKEHKSDSEDDYFSPYINDALNEAREIVTKGKATEKIGEHILQDTTSIKVDKTRTKGKPVEVIVKRSTIATHFSDEEEDYLSSGSDGEGLFDFIGGKVRSRANSCEDIDKLLAGGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJN2</accession>
    <name>A0A0N5BJN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJN2"/>
    <dbReference type="STRING" id="174720.A0A0N5BJN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000615500.1">
        <property type="protein sequence ID" value="SPAL_0000615500.1"/>
        <property type="gene ID" value="SPAL_0000615500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894362" evidence="2">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000615500.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="37250" checksum="F22F3A0EA0008CF6" modified="2015-12-09" version="1">MLYPKIFLLFFWFFLVGIISTFQLENFDQDNFINHSFYNENRPLISNDISGLSSQHFQEGSKTDVFLRVKRRAREIRARRQRFQHMRRREAKRRQNLQRRRQQMFRMRQQRKRQQQQQKRQQMIRQKAERRRKQQRMRQEARIRKRFKKMRQEIERLRRLSKTTTTKARTTTKKVIIAAVTTAKASKTTKNQAASTKDKSRKKSKSQPSEKTKEKSSKKSGSSDNAISKNVEKKKQETTKSNEKNEKSKTTAKDKKDKSDTEKIEEDEENKDDAEQDENDKEGTEEDQADESAAQDSQEDNDDTDPTEEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKG0</accession>
    <name>A0A0N5BKG0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA_28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKG0"/>
    <dbReference type="WBParaSite" id="SPAL_0000641700.1">
        <property type="protein sequence ID" value="SPAL_0000641700.1"/>
        <property type="gene ID" value="SPAL_0000641700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000641700.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="46048" checksum="BC0DF011B5DCB623" modified="2015-12-09" version="1">MTDDVNKKERRIYKLVLTGGPCGGKTTGQNRLISFFEGMGWKVYGVPETATILIGSGVKFCELNEEQVYSFQKDLLLTMLRIEQTFFNLAELEKEKDVLIICDRGTLDPSVYISKEGWNSIINDLNLSQFDLRDNRYNHVIHMVSAADGAEKFYTLSNNAARSETISQAIEIDRKTREAWIGHPYVDVVDNQDCKTFEDKISKLIQIVCERIGISNNEGLSSNSKKRKWLVMSFDESKFPHFEEFIVNHDYLISEDKNIQVRIRERRQGLYSTYTITTRIKHGDNHIETRTQINYREYIRYLQIKDHNKCTLHKRRRCFQYGTQFYHLDIFINPLPKSLNNQQLMILETYSTKSVNSPLPELPSFLNVVKEITNDKTFSMYNLADKNMNYIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKM5</accession>
    <name>A0A0N5BKM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKM5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKM5"/>
    <dbReference type="WBParaSite" id="SPAL_0000648100.1">
        <property type="protein sequence ID" value="SPAL_0000648100.1"/>
        <property type="gene ID" value="SPAL_0000648100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46068">
        <property type="entry name" value="PROTEIN CBG27172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46068:SF1">
        <property type="entry name" value="TRANSPOSASE IS30-LIKE HTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000648100.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="32021" checksum="B7D386516CF8EBFF" modified="2015-12-09" version="1">RIERKDDRSLIKMAKELQISRKSVQMIVKNELGLRSYRLLNGQVLTEQAKQNRKEKCKKLKDFFKVRRIEDVLWSVEKVFTVEVAKNSQNHRQHLSPAFKNTRKQKIGTRSQFPKSLMVWSGISASGKTPLLFIDKNVKINSKVYQKEILKKAVVPWKRNHLNFIFQQDWAPAHRAKTTIQFLETKIGSFLTKDLWPMNSPDFNPLDFSVWGFMEEQLRSRNIKNLVTLRKKLTKIWNNLDVNYLHRIIDSIKKRINACIKADGDHFEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKM8</accession>
    <name>A0A0N5BKM8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKM8"/>
    <dbReference type="WBParaSite" id="SPAL_0000648400.1">
        <property type="protein sequence ID" value="SPAL_0000648400.1"/>
        <property type="gene ID" value="SPAL_0000648400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000648400.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9720" checksum="EC6733E470307EEC" modified="2015-12-09" version="1">MDQEKLTAQKFIDLFGDIPGDYIDVPNNDEISIILEISANVSNSQMTNVVSNQEEYKRSRINENVNTTEMRKTPEVSKPTTGTKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKP3</accession>
    <name>A0A0N5BKP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-6A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BKP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000649900.1">
        <property type="protein sequence ID" value="SPAL_0000649900.1"/>
        <property type="gene ID" value="SPAL_0000649900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000139">
        <property type="entry name" value="ras-related protein Rab-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000649900.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24676" checksum="1CE32ED4A3EF8942" modified="2015-12-09" version="1">MPDFEGIGLYGIMSSDFGNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNANSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLVDKRQVSTEEGERKASELNVMFIETSAKAGYNVKQLFRRIANALPGIDNDKTSEPKQTVDIGPIKPRQIVTDEGSCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKW0</accession>
    <name>A0A0N5BKW0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKW0"/>
    <dbReference type="WBParaSite" id="SPAL_0000656350.1">
        <property type="protein sequence ID" value="SPAL_0000656350.1"/>
        <property type="gene ID" value="SPAL_0000656350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000656350.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10579" checksum="E09A65B8367C3FBA" modified="2015-12-09" version="1">MEIISTLKGLTTQTAEEEQELPLKRKMILDFPHHYDRDGDAQSGESNNSNNEDKSDEKLKVREIQETEDEEEINVIEKIVDYREINGAEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKZ0</accession>
    <name>A0A0N5BKZ0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7381 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000659300.1">
        <property type="protein sequence ID" value="SPAL_0000659300.1"/>
        <property type="gene ID" value="SPAL_0000659300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7381" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000659300.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20726" checksum="35E6BF944808A085" modified="2015-12-09" version="1">MPTILYYTTFISKRLFFCYGKSIFATKLEMVEQIVKDNNHYPPCCLYIQQIEYKKRFTLFNDRTIKAPEKVIDIIKSKKKDPYCKPNKYCPLRHRIKEVYKDGIFMYECFGNYFKSFQEARFYLIVRTKYRVRFNGERRISFDENDPATNVRFAKQKAIKFSKSLDSGLNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH1</accession>
    <name>A0A0N5BMH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Structural protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH1"/>
    <dbReference type="WBParaSite" id="SPAL_0000711100.1">
        <property type="protein sequence ID" value="SPAL_0000711100.1"/>
        <property type="gene ID" value="SPAL_0000711100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711100.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21433" checksum="463D8EAB1E831CAA" modified="2015-12-09" version="1">MAYVDFLKRVIEGVVNEVNNYPLVIKASDDMNNGFISTDNHSILSRTKIREIFPEFLKRLNEFGKVTISVNEISVQTRFDFVQSEFHKELEILNYNIIVNLDIDLKEELHHIDTKIELNIGELYEGDKEEITFGDKCDSSKVTGFTTVTILQKSGFMKKKSSDNEYTFNLHVSDFDGNIVYCVCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BND7</accession>
    <name>A0A0N5BND7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Retinoid-inducible serine carboxypeptidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Serine carboxypeptidase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BND7"/>
    <dbReference type="STRING" id="174720.A0A0N5BND7"/>
    <dbReference type="WBParaSite" id="SPAL_0000741600.1">
        <property type="protein sequence ID" value="SPAL_0000741600.1"/>
        <property type="gene ID" value="SPAL_0000741600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894574" description="Retinoid-inducible serine carboxypeptidase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000741600.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51607" checksum="51A68A9D5BEBC796" modified="2015-12-09" version="1">MITFRFLIIFFIVPILSINSFKSSDTVNTLSGVIKYFEDWGYTDIRDGAHTFWWLYARENTTADANRPLILWLQGGPGASSTGFGNLEELGPKDLNGNDRNHTWLQLADLVFVDNPVGAGFSYVDDNTKFTKNVAEISADLLSWAKDFFNNQHPEYKKRPFYIFCESYGGKMAAEFSRYLFNAIRSSEINVQFSGVALGDSWISAMDFVNTWPQYLYSLSFLDDRDLALANEQAAKCQKLVDNGKYSDATNCWGDMENLISELTNDVSWYNILKTSGTDDWSTAIKKNLLDTPIKKLYSHYVSPLQNDALSDFMNTIARKKFGIIPSSVQFGGQSNAVFDYQSGDFMKPNYATVDYLLLNNVNVTVYNGQLDLICDTLGVNKWLERLTWKGMLNFYSTPKVPYSLKNSQQTAGFSKKYSNFQLWYIMKAGHMVAYDAPIATIKMVSTLINKGNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPD9</accession>
    <name>A0A0N5BPD9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPD9"/>
    <dbReference type="WBParaSite" id="SPAL_0000776500.1">
        <property type="protein sequence ID" value="SPAL_0000776500.1"/>
        <property type="gene ID" value="SPAL_0000776500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000776500.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44798" checksum="56D9DC74E647C798" modified="2015-12-09" version="1">MSNIERNINISLPRKTISELYNDAKDSNQLIREFIKDYEAKGFQRIKVENFCKSFMETEMVNDILVHYEMPYLSYRIMNEAAGTDRYTHQLATLVFKKSCCIVFNLGLYIGEGDDKYIHKELKSSFPRCDFDFAKLDMRNIQSEYRRISSNNNVVDRKRKGNLPEVGSTTNLAKRPNILKVNNTIISNIRHRNEVCKNVGTIKANIPISSPCSYNNATGVNVSRGLTGNSEDESCVDKSLFGEYLEKKRITLLDQLSKNFNLSFPEREQLSCFLSTYLTYFIQKKYMELKNVDKVTKVTNNSMLRILTFMTKKDSGKILFSKILNNEISPKSLSEYKDEDFCERTISFAANEILYNSELSDHPALQTYMCRKCATMHSRNDSCRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPY4</accession>
    <name>A0A0N5BPY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000796000.1">
        <property type="protein sequence ID" value="SPAL_0000796000.1"/>
        <property type="gene ID" value="SPAL_0000796000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894947" evidence="1">
        <location>
            <begin position="20"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000796000.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="58610" checksum="1A9DE4B25EB5337F" modified="2015-12-09" version="1">MNAFILILYYYGLFSVAQGDSTGRFEDTLKDVKRFRFETLYKNAASRSLNNYVDLDVDPCDNFYKFSCGNWIKTMEKDRGDSELFHYDSRTTNFNNFIIGNIFFSFIYLLSDSLKGKYNNESNAIKNIYNLRKKCIQLPRDRIGNCVAEIAAFGAYAYSSLYVKKNRIEIDKHGNYNIIEDMIKRIKEEFRLLIDEKENIFDKESRDNLIQKLNEMEFVRHFFEHELSSVLFMENCYKNIGISENNTIEDVLKNIENYKLLSESNNQTNSCISNIFKYNKYMTLFVYTNAMYYSIYNKFTTSSDAFNEPSFNRHFPNSLNYGYIGYTIAHEILHGFDSDGYKYIFGEDKEKYVIVSSESIKKFEIKSDCLVKQYNDQIESITGLNVNGSLTLDENIADNGGLKIAHRAYMKYLQSIGGEEPKIPGFEKFNSEQLFFISFGRSFCEHRSKESLKRMMEKQRHAPAEVRTIVSLSNYKPFSDAFNCPVNSKMNPVHKCELWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ75</accession>
    <name>A0A0N5BQ75_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ75"/>
    <dbReference type="WBParaSite" id="SPAL_0000804300.1">
        <property type="protein sequence ID" value="SPAL_0000804300.1"/>
        <property type="gene ID" value="SPAL_0000804300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000804300.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20940" checksum="79776E279A7D75F9" modified="2015-12-09" version="1">XTNAELMDETFDLLDIEHSPRPTVENLEADGQHHLDSTEQLPEKSLVSNTYSEIDGFTNQFTLKDYTYLPILFSQVETSSIYVIFGICLTNQGNLLVTIRKSQVIGFLNGTEICKVVEVDVVSFNKRTPGTEEYNMRNNYVHINYLGFKLILIPRRSIHRAGVRFFKRGVDSRSNLANYVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQG9</accession>
    <name>A0A0N5BQG9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CUT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQG9"/>
    <dbReference type="STRING" id="174720.A0A0N5BQG9"/>
    <dbReference type="WBParaSite" id="SPAL_0000813400.1">
        <property type="protein sequence ID" value="SPAL_0000813400.1"/>
        <property type="gene ID" value="SPAL_0000813400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF32">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="9">
        <location>
            <begin position="322"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000813400.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49995" checksum="3F9FD17E1495FF9E" modified="2015-12-09" version="1">MGFEVKYISSGDVPDPCDVPGDQVDAATDEEVCPPKSECKGPSPNISGPFNETNKSKNPFQRNGSHYFEKSGRPIYLQSHFCHPPTFWAANYINAPRPNLDHPQIQNCYSNLHHPPLHYNFPSNTNNKYQRRTEYGKINYDYGEPGNNTMTNDKPITRCCCCGRNRVYDGDSEIQKGSCNVNNILQEHRVVQYNRREFVVPQRNLYGIHEVARERVIRHVSGNRITRPMEPLPSDMGMCKLIEGSNEESQPTILPIDSSINNSDNSSTTRVEESVSPLPIDTLFSVSDEGNGNKSSNKRINTSKKTKRKLNKDNNDSDGDSCSTSDSLLDIDTESLCRFVSEELKKHSISQATFARKVLNRSQGTLSDMLRNPKPWNQLKTGRVTFVRMHRWSCLPEDVRARILNEDSRFTRPERRRRRNRPKINVTEDILTNDDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQP2</accession>
    <name>A0A0N5BQP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000820400.1">
        <property type="protein sequence ID" value="SPAL_0000820400.1"/>
        <property type="gene ID" value="SPAL_0000820400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000820400.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32507" checksum="9B0AFDDD337FACB2" modified="2015-12-09" version="1">MAYYRESSPIPGYTGHIPGSKFHIGGGINRKGIVNNDHKMTVEDFSTGISNDFDNFSIVDKLKNDESRLPSLLNFEIDKHETKEKYLDEENDSEIRQVFSEIPSYRKGSISSNRSVVSKISKKSNNSVELSLNKHEFDSNKGDNASFLNSERKSIKKFQYENEEVRRPMTVGRERKEKLKKKMENIKPTGIWDKKPIPYNEKKTSIIDNIPEMKNNPFEGAEKGWWSEGQALVNLKNIKKNQFNDDSYIDYQKIMTDGSNKYNLNYTENSSIIDDFKNCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR03</accession>
    <name>A0A0N5BR03_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR03"/>
    <dbReference type="WBParaSite" id="SPAL_0000830900.1">
        <property type="protein sequence ID" value="SPAL_0000830900.1"/>
        <property type="gene ID" value="SPAL_0000830900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000830900.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18314" checksum="1E62F85528CEA92D" modified="2015-12-09" version="1">MSQNPLLPWKDCLPLVSYAMNNSRTIGREFTATERLYATSPRTILHTTVNEKSYTKFIDRHPEISEMLSRFFIIRRIENDAYEQLRLQDNKKKFEETQGYKAGQTVYYRKNRKHKFDNNYTKATVIADIGPNKVVSKAKKHGKWRKVNKKNVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRA1</accession>
    <name>A0A0N5BRA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRA1"/>
    <dbReference type="WBParaSite" id="SPAL_0000840400.1">
        <property type="protein sequence ID" value="SPAL_0000840400.1"/>
        <property type="gene ID" value="SPAL_0000840400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000840400.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11779" checksum="03AA661659249B62" modified="2015-12-09" version="1">MAAWGEFWSIFFKVCDFISVDQCLRDMFRQHDKDMSGFIGKEDILVMLLNADKVKENDPIFKTNLRFLINIIKEADKDGDQKISFEEFKDYINKANEQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRM6</accession>
    <name>A0A0N5BRM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRM6"/>
    <dbReference type="WBParaSite" id="SPAL_0000852250.1">
        <property type="protein sequence ID" value="SPAL_0000852250.1"/>
        <property type="gene ID" value="SPAL_0000852250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000852250.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7921" checksum="EE71E2D6348B7DC0" modified="2015-12-09" version="1">MAFGRLPNYDASETNDEDSGDYYRCQMKLGGLTETEEKMYFWIRTKPHGSDIFEVEAYFHFAYRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS02</accession>
    <name>A0A0N5BS02_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS02"/>
    <dbReference type="STRING" id="174720.A0A0N5BS02"/>
    <dbReference type="WBParaSite" id="SPAL_0000864800.1">
        <property type="protein sequence ID" value="SPAL_0000864800.1"/>
        <property type="gene ID" value="SPAL_0000864800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RBD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000864800.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29728" checksum="CCA32F882E4DCA49" modified="2015-12-09" version="1">MSSLVVLSPTAHRTVVKVTPSKILQEVLEEACLKQGLNPESYKLMYQKKILDLSLPFRLSGLSNGATLNLLYSEPLSDNVQCTIALQSPSGSRDQKVLSNGLTLLEVLEKFGVDLTSREKCPIVMVMNKSFVGTEELKIKTLKSVGIISGRTLIKYDFKVLSEQEQIELEKRLEDEKKRRKKMEETFLIKKKENEERELLKLQMEQESEKRKEFYEIKNREREMELERLKKEYLEELKHKEEQNEESNQEENNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTJ9</accession>
    <name>A0A0N5BTJ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTJ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BTJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000918100.1">
        <property type="protein sequence ID" value="SPAL_0000918100.1"/>
        <property type="gene ID" value="SPAL_0000918100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF98">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="59"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000918100.1"/>
        </source>
    </evidence>
    <sequence length="739" mass="83349" checksum="190E9DC946E03F05" modified="2015-12-09" version="1">MGVFNGTSSFIFFYYIFLLLISIIVANNNNTVKDAPEYHIFSDNFHHVSTPYTVSLWLIIAAIAKILFNVSKRFSDTFPDSALLIVVGLILGLILKEIHVDSSIFTLDSTTFFIFLLPPIIFDAGYFMPNRALFENVDSVLLFAVIGTIFNTLCIGFSLYAIGYMNYFSVQFSIFEILCFSALISAVDPVAVIAVFEEIHVNEFLFINLFGEALFNDGVTVVLYQMFKQFLLIGPDNVTPMDYIKGGISFPVIALGGTIIGIIFAFIVSLLTKYSQKVVMMAPVFVFVLPYLSYLTAESFGLSSILAITSCGMLMKQYVKENITQSASVSVKYFVKMLAHSSETAIFMFLGLSTISSGKHHWDTAFVVCTLVFCLLYRAVGIIVQCWVLNKFKKEKFSIVDQFVLSYSGLRGAIAYGLVVSLPDNIVAKNMYVTATVAEIFFTVFVQGITIKPLLNFLDVKKKDEREKTMLETVYSKYFDYAVSGIEDIAGLKGKNSFRTSFERLNAQILKPLLIKKAKRNKFDASQIIRAFKKITIEEALREREIKSSDREKSGLYIAAGLASPINASVNLGHKISGTLEVEKALSRINSTRSKGTSVISEKPIKHTYQDMEDENRKNIFSEILKYLPNEATAEVLTNAIMNKVNKKLNDIAFSYNYDDSDESDIEDNYLKSMQKKELHHILSHERLNTINYDRNDEYDNYDTKRRTRSTLNTVSPVNRPRSSSISFNFSVKNGHEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUT8</accession>
    <name>A0A0N5BUT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUT8"/>
    <dbReference type="STRING" id="174720.A0A0N5BUT8"/>
    <dbReference type="WBParaSite" id="SPAL_0000960700.1">
        <property type="protein sequence ID" value="SPAL_0000960700.1"/>
        <property type="gene ID" value="SPAL_0000960700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000960700.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29647" checksum="592E6E932AE7EEF8" modified="2015-12-09" version="1">MIFVLDVTNNNAQVLGQLQTYMTTMLRDIASTGRRWISEFSVLGYDQTKTYHLGSGGRRDIDVIATAFSKAYNLSLANSPSCIPVRVWETIETATHLSTNFGYIFNFQSTPPLETVPELIALGKNAFTCNSNSNTFKNIKLSCEESEGDAFDINPSNFQYILRIILTFYSSGVVYKKVMNDCTSGCYLYYPIDSHTQNAQIFINGASGNISQQIFMPNLTALANVLFLLQDTTTGWNIIEMSRACPSGWNDLSSQYCYTTVSTPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV31</accession>
    <name>A0A0N5BV31_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV31"/>
    <dbReference type="STRING" id="174720.A0A0N5BV31"/>
    <dbReference type="WBParaSite" id="SPAL_0000969700.1">
        <property type="protein sequence ID" value="SPAL_0000969700.1"/>
        <property type="gene ID" value="SPAL_0000969700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF244">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="561"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000969700.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="75271" checksum="B9A6CFD86CF15594" modified="2015-12-09" version="1">MSDCKVKFELDGSRGSNLFPPPSSLSASAHIKNIKTYHEKYRSSLNETDKFWRDIASELYFEKMTDNGLEWNFNREKGKVFVNFMKGSKTNIAYNCLERNISRGLGDKVAFKFEGNEPGDEDSITYKELLEKVIAFSAVLRSKGVKKGDVVAIYLPMSFELPIAMLACARIGAIHSIVFAGFSSESLANRIIHCKAKILITADAFYRSNKLIDLRALAISAVKICEKNNYQLDSVIVVDHSSKITIPNGAPQPSTSAGPLDIECSWDSELKQAFGVESPVEWMDSEDPLFILYTSGSTGAPKGILHTTAGYMTYSYYTCKITFDAQDDDIYWCTADCGWITGHSYVVYGPLMNGMSSIIFEGVPTYPDAGRMWDIVEKYSVTKLYTAPTAVRCLMGFGNEIVKKHNRSSLRVIGSVGEPINPSAWEWLYYVVGEEKAAVVDTYWQTETGGHVIVPIPGAVPTKPGSATLPFFGVVPCILDNDGSLMEGPGEGNLCFSRPWPGISRSCWGDHERWEKTYFSSFNGYYFTGDGCRRDEDGYHWVTGRVDDLMNVSGHLLSTAEIESALVEHPYVSEAAVVAAPHSIKGSFPYAFVTMKEGSKLTPSVATELKLAVRRKIGAIAVPDVVQEAPGLPKTRSGKITRRILRKIAEGDVNADFGDTTTLVDESVITKLLNNRPESRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVH0</accession>
    <name>A0A0N5BVH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVH0"/>
    <dbReference type="STRING" id="174720.A0A0N5BVH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000982800.1">
        <property type="protein sequence ID" value="SPAL_0000982800.1"/>
        <property type="gene ID" value="SPAL_0000982800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
        <property type="entry name" value="CCD_aECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435">
        <property type="entry name" value="PROTEIN CBG14344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435:SF5">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23626">
        <property type="entry name" value="CCD_aECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894915" evidence="1">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="aECM cysteine-cradle" evidence="2">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000982800.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25571" checksum="E9FA04F38CA46DD0" modified="2015-12-09" version="1">MNLQFHLLFIIIIHIILISSVESSKRYKENIEKLRGLINGAKSFTNILKESRPEKTKRYKCVEIIDDEEEVNFEQLPIPNIKINNDNSFPIIDETSQNKFTTFNENTPDIEEIKYVTLPHQTTESVEFILTTMKPIPTTSTEKPSIDISDVPRDSKNRPLLLAPEHCKMIKKYADMYMVTNIRQWAHNHCSFAKMYLPTATCGEIDILVDSCFKQKFINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVN0</accession>
    <name>A0A0N5BVN0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVN0"/>
    <dbReference type="WBParaSite" id="SPAL_0000988600.1">
        <property type="protein sequence ID" value="SPAL_0000988600.1"/>
        <property type="gene ID" value="SPAL_0000988600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000988600.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13260" checksum="EB5AD999A2B8C683" modified="2015-12-09" version="1">MESENYIKTNFTNSSVLPSKNDNSTNPITKPDASMSSDFKNVPDCSKNNHIHSTPAIIKARRIHEQLHIQSPSDNMLSPCTKKLFSNKPRSKKISASHPINILRIKQQEALYNQKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA4</accession>
    <name>A0A0N5BWA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA4"/>
    <dbReference type="WBParaSite" id="SPAL_0001010450.1">
        <property type="protein sequence ID" value="SPAL_0001010450.1"/>
        <property type="gene ID" value="SPAL_0001010450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010450.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8247" checksum="F59DC213DE94F31D" modified="2015-12-09" version="1">MSIKKKIVCKESPVLETINKTADKSDIWIWAHLLYIIDVLFEKEKISLQDKEFLTLSVKQRLLFIALNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWL1</accession>
    <name>A0A0N5BWL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-galactose translocator 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWL1"/>
    <dbReference type="STRING" id="174720.A0A0N5BWL1"/>
    <dbReference type="WBParaSite" id="SPAL_0001020600.1">
        <property type="protein sequence ID" value="SPAL_0001020600.1"/>
        <property type="gene ID" value="SPAL_0001020600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001020600.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39256" checksum="753EE38BBA2E35E8" modified="2015-12-09" version="1">MVLHGKKIKPVKDGINTKEITIDVDQEKDKNLTKLNDYETSIFFKIYIIIGIVACWGSYNILIKYTVINVKEEDKFFSAVVPVLCEILKLLLVYPLYFREQNYNIKKFFSGLYNEILMKPIDFLKISPPAVCFIIQNNLEIIAAQNLSPGVYQVTCQLKIVTSALFMVIFLKKNQSFKRWICILLIFLGITISPFGEEINKSVIIGLSSVFAISILTGFASVYFEKMLKNGTQSSLWLRSIQLYTWGLIAAIICMMSKNVNDIIEKGIFHGFTIIVWLAMFVLAIGGIYTSLIVKYLNSLYKCFASTITIALVASVSVFLFNSTLSVTFIISFTIVVISIITYNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWV5</accession>
    <name>A0A0N5BWV5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWV5"/>
    <dbReference type="WBParaSite" id="SPAL_0001029400.1">
        <property type="protein sequence ID" value="SPAL_0001029400.1"/>
        <property type="gene ID" value="SPAL_0001029400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001029400.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57961" checksum="CE3A83C7F3CF23A2" modified="2015-12-09" version="1">MAKKLDNKEKNGTFHYMENATAWTSIHVVCLLAFSSAVQFTLYFSSTNQFLKTFDPNTTEFFYGLVISSYSVGNVVFSPIMGYLSNKLRQIKLLLYVGLICQFVGNLIYFYVEILPFDKKIFLLIGRFITGIGASNVSLMKAYISGASLPQDRSKCIAYITGTMAVGAFCGPALQLIFVHLGHPGINILNLFRIHMFNAPALAACLFVIINFFFVFFFFEEVYVDILETPNNNYLSLPPYNFKSILICYLTRFCQTFISTNLETLAAVISMSVFSFTALESVNVISLANTGRAIIALLISLLYVFVKIENYVSLRNTIIICTFWMILFHIITYPYGLYKNVLVYNSTITYFNNTSVGCNILKHSWCESLTPCNPYLYYITHTIIIGSTYSAVNICLNTLFSKIIGPRRQAFEQGTLNMSKGISQMISPPFIGYIFDYAGLKVVWIIHISFLSGAIILWIIYYKKMVPFKLFNDKNYNDIFSIELSNSNISQDTEKSIHSGNSLSTSQNILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWY9</accession>
    <name>A0A0N5BWY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RadC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWY9"/>
    <dbReference type="WBParaSite" id="SPAL_0001032750.1">
        <property type="protein sequence ID" value="SPAL_0001032750.1"/>
        <property type="gene ID" value="SPAL_0001032750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001032750.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8465" checksum="6202F9F58F2D0764" modified="2015-12-09" version="1">MTCQVKNILIMATHRFNRGSYTVIQSCHSNKNDEVRKYLINKENNLLAILEITDHIIFLTCDKLKLFLKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXJ9</accession>
    <name>A0A0N5BXJ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Desmoplakin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001052500.1">
        <property type="protein sequence ID" value="SPAL_0001052500.1"/>
        <property type="gene ID" value="SPAL_0001052500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001052500.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47116" checksum="2075C2923B69CEA3" modified="2015-12-09" version="1">MDRQISTLLLEKEKLSKNISTLDANLLEYIQKLVEENESLKAENESLKSEQRHSNGTQISTSQTASSHSHYYNSKNDDNTSANCLSSTFATSPKDLSIKKMCVTAKINAMNELCCGMFQRLKSVALVIKDILKDEDSEIIGDLVLCVDAAKYEISNSLHEASILLSQDVEVHRNDIDNCKSENPQIGSLKDLSLSESVLITLKDNQDHELKRKCEELEKERDYYKELYENNAASDSTNASNSGSLCDVSEDSRSEYGKENWVVNDDQGYLLLHQVIRLIDNITNYCSKKVDEVDVALRNPLKNIEDVSKKAAKKLQQYDRLVAQAKSEDCHVTCNNRPFVDRHSPLDTSDKIKKPHKDKRISGESGFTKEIKIKLMKELKGIRETMVYVSEATTEMFAHLQFKDKSKRKEKNTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXN1</accession>
    <name>A0A0N5BXN1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane-bound O-acyltransferase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXN1"/>
    <dbReference type="STRING" id="174720.A0A0N5BXN1"/>
    <dbReference type="WBParaSite" id="SPAL_0001055500.1">
        <property type="protein sequence ID" value="SPAL_0001055500.1"/>
        <property type="gene ID" value="SPAL_0001055500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001055500.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49697" checksum="D5F2AFB2D613641B" modified="2015-12-09" version="1">MNVNQVSKTLRTIYPFIVGIYICYFCYGSAIKHPIFLTLGNYLILKYSPGPYVHKASFIFSMGYLFYIHFYRFYVLTSYSIDVTGTMMVLVQKCTTLGFSLHDGKCKKKEELNDIQKNEAIVEVPSIINYLSYMFSYQTVMVGPLCFYTDYKKYIDGDHLKVEGSKQPCPKKAAIKKLIASACFMVIIILFGKYSPEIIATPEYLQLSWIKWCLWWFFVIFIQRVQYYYVWVFADAVANVSGFGFNGYDENGEEKWNLVSNVYPLKLEMAQTFKETLDSWNVATMFWLRRVAYDRVPKNMRTLTTYMLSAVWHGFFTGYYLTFATGALFTLAGRYVRRSLRWRFLKNPNLKLIYDVVTFLSTKIALAYATLPFVTMHLNPGWFCFKRVYFIVHIIALFLVLVIPKILPPEKKENIKNEGKKDKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY01</accession>
    <name>A0A0N5BY01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UBB protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BY01"/>
    <dbReference type="WBParaSite" id="SPAL_0001066400.1">
        <property type="protein sequence ID" value="SPAL_0001066400.1"/>
        <property type="gene ID" value="SPAL_0001066400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010623">
        <property type="term" value="P:programmed cell death involved in cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000387">
        <property type="entry name" value="Polyubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001066400.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24992" checksum="BB974FC73038037F" modified="2015-12-09" version="1">XQIFVKTLTGKTITLEVEPSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY20</accession>
    <name>A0A0N5BY20_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="STRING" id="174720.A0A0N5BY20"/>
    <dbReference type="WBParaSite" id="SPAL_0001068100.1">
        <property type="protein sequence ID" value="SPAL_0001068100.1"/>
        <property type="gene ID" value="SPAL_0001068100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90234">
        <property type="entry name" value="Zinc finger domain of DNA polymerase-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="461"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="745"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1203"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001068100.1"/>
        </source>
    </evidence>
    <sequence length="1395" mass="159116" checksum="D3D5ABF388223AEA" modified="2015-12-09" version="1">MSSSDEEIVINRSAKRSSRNVPKNSEREETLAKMREARASGLKYKPEIEVKDVYETVDEEEYQRIVNEKRRNAFVVDDEGDGYYDDEEEEFLDEYDDAGGEKKPTKGKKSKNDKIVKGSIKNYFSAATKEKVKDDKAVKLDEDEVLKDLLKELDGDGESVNEVVVEQPSRNPFKRHLESPVACGKPIKSARISSTPVAGDSTTSEKVPVVKEEFTTPVRPIDANVKKDSTEDVVMEEVPLKTEDALVDDFDDSLDTTAFENEKIKQERCIGVVANTLKQEQTTESLPVQNHDLMNEDDFGSDEDIQLSENFNGSVGFNEPGNDDSNSIVIHLLDAFEDPIKHPSTVFLFGRVQKSGNYNKSVCVKLHNIERQVFFIPRTKRVVDQNVTDIPVKIDDVHEEVKNILLRDYNILNFKSRLIKKKLAFEDEEWNNKEVECLEVRYEAKFARLPKTLSGETFFKVCNTTSSALERVLLECKIMGPSLIEIENVVPAGSKISYCELEYLCNMEKMNNIKNLEYFKGPPTVTKLISFNVVTELNQKNENRIVMINGVYDLKSSNVDKTPASSNNLNKFCYMTTPAKTSYPYDWKDKCSRKGIKNVDMLKTENEVIIRFLEFLERHDFDLYIGHDFTEQLAKLVSRLDKLKIPQWSRISRLKRTIDIHKVGFSKAAQWELTGGRLVADSRTAAMELLKAKSYDLDDLVEQLFGEKIDEGLSDGNIREHYSNGMKLDAIPLFAQITRTVGGVFSRTLLGGRSERNEYLLLHAFYDRNYIAPDKHTKVSPRAINNENGNIGSSRKAAFSGGMVLEPLKGLYDTYVILLDFNSLYPSIIQEYNICFTTIANCTKEPNNEDDLPNAPGSKKELGVLPIEIRKLVERISEKKKLEIKQMALKLTANSMYGCLGFNASRFCAKSLAALVTKKGRDILESTKSLVERSNYKVIYGDTDSIMINSNSRSLQQAKDIAETVKNMVNKCYNSLEIDLDGIYKKLLLLKKKKYAGLSVNPNNEKEEKFELKGLDIVRRDWSVVAKETGNTVVDLIFSKNRDELGFEIHSMLGSLKNKLVNNEIPLEKFEIFKQLTKNPTEYNDVKSQPHVSVALRLNNAGKNHYKAGDVIKYMICNDGTGNSATQRAYHKSEIERNPALKVDIDYYLKQQILPVITRLCEPIEETSQIQIAEALGLDTTGLRRKMYENDNQIDNNDVDATFEQDFEACKSFAFECPNPECMDNIEMRSPILMFGNTCKLALERCSKCECPFNENKGYIANCLTEQLRNQVKEYCASLYVCDDEICAYQSRRPPIKMSRLGPLCLKCENGIMKKKYTIRKLYDQQCFFRNIFDLEHAMSKERMSLEVRKQLESDAALPECREFYSFLLNIVNKYLNMNSFNIVDLDFIFAPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYF1</accession>
    <name>A0A0N5BYF1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYF1"/>
    <dbReference type="STRING" id="174720.A0A0N5BYF1"/>
    <dbReference type="WBParaSite" id="SPAL_0001080900.1">
        <property type="protein sequence ID" value="SPAL_0001080900.1"/>
        <property type="gene ID" value="SPAL_0001080900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="247"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001080900.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55583" checksum="4CA0CB962CBACCC6" modified="2015-12-09" version="1">MVAADEGTRRLIRNELKDAMDTYHMCYNVQVTNFLTDLFTSYDKGKIRSYVDKIAGVMRSGGVEVKALSLESLKIILTHLSAVKDDNLKIINVFEDQYGDEEKEWKRKSFLPTEEEICNLQTGRLLTIKRLMEDRKNTIKSKIPGELRCIQTLFGYPKLDTPVSIIGCAFADSKNRYRIEDHETTIKMNLSKNCTYGDGILSIGAPLMFTGLYADGVLTVNNIQLPPLIKVPREVKESKISMSDKLIFLSEVNLDNGDCLRSIHQLLSGFSQSPPKCLIMMGNFVKSPLNSGSFEEYADGFRRLSNVLKDVIGLYPVWKGVKYVIVPGDQDLPSSIMFPKLPISQCLRKYFSEGIDITFTTNPTVITNKGQKIFVCRSSNIIEKMCRDAFHLPQDLTKISDHFVESIIRMRHIQPLPNYISPISPAFDDLFSLEVLPDLIVLGDRFKSYNSSVSDCLVANPGQFTKANGFEFLVYYPRDKVCEYSAIGEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYF5</accession>
    <name>A0A0N5BYF5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYF5"/>
    <dbReference type="WBParaSite" id="SPAL_0001081233.1">
        <property type="protein sequence ID" value="SPAL_0001081233.1"/>
        <property type="gene ID" value="SPAL_0001081233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001081233.1"/>
        </source>
    </evidence>
    <sequence length="61" mass="7064" checksum="5C272462572E4F47" modified="2015-12-09" version="1">MMMINGREYNSLHTDLNIKLHKLSVLINNYFRVIINLLLTSSFLSVAITPSFLRQNVSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYM3</accession>
    <name>A0A0N5BYM3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYM3"/>
    <dbReference type="WBParaSite" id="SPAL_0001087500.1">
        <property type="protein sequence ID" value="SPAL_0001087500.1"/>
        <property type="gene ID" value="SPAL_0001087500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001087500.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="43058" checksum="409AB0E7E8204D5E" modified="2015-12-09" version="1">MNNNESSYDFNFEYYREKRKVRGRNFYLWKKSIPFYIERNLNRNLIVEALRGIEAETCIRFHEVKQVHRRMSGIRYSPGNICFSFLGKRLLRGFQKIFIAKYCEKLGPIQHETLHALGIDHEHSRIDRNKYLFVQKENIEPSSLNDFTTPRKIHSNTLGLPYDYGSIMHYDMFAFSKNKEPTLLPKHMLYNHTMGHIHKLSFIDIKTINLLYCRNKCSFKIDCDNGSYQHPTKCFQCICVEGFVGKNCNHFTTNLPSCGKSMHVAQESPREIIVIGKINCYYQLTTEKNSKIMLKVVYTKIYPSHGTFCWPENSLEIKYWEDKTVTGARFCGSTQNIVFLSKSNVVIVYFRSTNALNIFMLMFKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C062</accession>
    <name>A0A0N5C062_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C062"/>
    <dbReference type="WBParaSite" id="SPAL_0001139300.1">
        <property type="protein sequence ID" value="SPAL_0001139300.1"/>
        <property type="gene ID" value="SPAL_0001139300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7381" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001139300.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31553" checksum="8541B1FEE8B15A66" modified="2015-12-09" version="1">MVKTILKEKYTDKIEDVCIYNSGHRKRNMIVKVIVPKCESILPYVYQHYSSTKIDVINPSTYGEDVYSCNNRIFYDFESALDYALKTRSYITFNPRGGSPIPPLRDFCILTRYGRICQMKNSPLPNHWKKIWSNCNSDCYFYKNFIIAKKNYLEEINFNRKIYKDLPLTLNAKLSELAQRCANLMAKLKRLRSEQTKNINEIVAYAPNANGMYLMKLLFEDSYVNRNTNKILPKNSKIGQLLSPKQKFIGIGMTKEGSGVFICLKYTSMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1F9</accession>
    <name>A0A0N5C1F9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1F9"/>
    <dbReference type="WBParaSite" id="SPAL_0001183400.1">
        <property type="protein sequence ID" value="SPAL_0001183400.1"/>
        <property type="gene ID" value="SPAL_0001183400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001183400.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11476" checksum="D09C5AE5E0B1E53B" modified="2015-12-09" version="1">MDPDNFEGRRRLPKNVQDIIINTGNLITSIQQDSGSNEIMNSLIKQFVSFDSIIESTHAGVNKLAATIDGIEKYADSLTNMVPVVYDVNECLSKIKNDASKMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1I2</accession>
    <name>A0A0N5C1I2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1I2"/>
    <dbReference type="WBParaSite" id="SPAL_0001185500.1">
        <property type="protein sequence ID" value="SPAL_0001185500.1"/>
        <property type="gene ID" value="SPAL_0001185500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF3">
        <property type="entry name" value="I-BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001185500.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43549" checksum="3E9D8A536A00EF90" modified="2015-12-09" version="1">MFGSHICLTFAKYKNYKIIPNIIKSTSYSYDNSIILILHISSDQKLEKLKNHLLNWEGYISLAVYLDSHTFFSFETICTYCRLKEIIGISNKLSVHFVYNNIFNSTIDDYLLSQIIGNICYKYPITYLNQSCTNILTNEKELGTKMSKYPANILRNIARKYCYGKYIVIADVDHMFSRNFHDKMLNVAKNKLNNESDNKYALVYRIFEVKTKNLSEAPKDKVELKELMSKKEAFVFHHYYKNAHSIPKLDEWLSIPDQMVPDIQFSAKYDRSYWEPQFVSLNDIPYHDETFPYPNRDNTVLRWEMCRDGYQFLIVNDVFMFHLGLKEKNESKAVAIARSLTNTQKDNFLTKFRKLMDLKYPLTAKECPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1R1</accession>
    <name>A0A0N5C1R1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1R1"/>
    <dbReference type="WBParaSite" id="SPAL_0001193225.1">
        <property type="protein sequence ID" value="SPAL_0001193225.1"/>
        <property type="gene ID" value="SPAL_0001193225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001193225.1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6219" checksum="199B9DBDEE96AA55" modified="2015-12-09" version="1">MYGGPYGRYGGYGGYGPRHHHHHHHHHGPPPRLGLGILPPRPVIRRPVPIIVPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Z0</accession>
    <name>A0A0N5C1Z0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Z0"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Z0"/>
    <dbReference type="WBParaSite" id="SPAL_0001200800.1">
        <property type="protein sequence ID" value="SPAL_0001200800.1"/>
        <property type="gene ID" value="SPAL_0001200800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001200800.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39932" checksum="CF537311A009E259" modified="2015-12-09" version="1">MGLEDASIVERNFLRLVKELNCTNRDHDKEVRCMQTKNASEIINTTETISNPLQSVLRYPFMAVDYDGYFFERPVEKILGTEKFKKDVDVLLEKTTNESTIYMNHYLQNTTYGCPFYPNKPVEDPDNQCNMTKKQYLKSIEFLVKILNLNVTATKKIRKIYSNLTLISYRDRAVRIFVDFFFDCDFLEFGKKIDTYINKTKDKYFFVLGKRISINPWQLFFGVTHDCQSHYMFGHPFLNATAYGYNATMEQEFSSQYMKILSKFTHNAKLYKGYPDKIWNYWPNFNAGETFGVFVNSTLRGWDQYDIINISTHTCERVKNIKLCYRLPRFSIPDICLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C275</accession>
    <name>A0A0N5C275_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C275"/>
    <dbReference type="WBParaSite" id="SPAL_0001208800.1">
        <property type="protein sequence ID" value="SPAL_0001208800.1"/>
        <property type="gene ID" value="SPAL_0001208800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001208800.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="57286" checksum="1F219B857F30A726" modified="2015-12-09" version="1">MFFVSQGCIPDLLKNILKDVEKFSSKKLYNETASRSLYEYIDLNVDPCDNFYKFSCNNWIKSKKKLRGSNKSFAYNGKTSNFDYFVKGKNSFVFIDLFLEFEYGKYNNESRAVYTLYKLRERCNEVSEDKLDDCQLIINNFGTYALSVIFLRKNKINSENNGDYNIIEDMIKRIKEEFRLLIDEKKDIFDEETRKHFLHKLNEIELKRNLDEYNLSNVTSMEDCYDNIGISYNDNIENIVKTIEHYKALSIKDGDDFNSCRRKIFQPDAYISDYVYSNGLYNFDENYFFISSDYLNEPSFSRNYPMSFNYGGIGYTIAHEISHAFDSTNYKSMVKGGNKNKFNVTKKSIRSFNEKSDCFIKQYDKQKESITNKNIDGVITLDENIADNGGVKIAHRAYMKYLQSIAGKDLVVPGFEDFTNEQLFFINVGKKNCQYSSKDILEKQIKNSEHPPGEIRVNVALSNYKPFSSAFKCKLNSKMNPESKCELWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2N6</accession>
    <name>A0A0N5C2N6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2N6"/>
    <dbReference type="WBParaSite" id="SPAL_0001224600.1">
        <property type="protein sequence ID" value="SPAL_0001224600.1"/>
        <property type="gene ID" value="SPAL_0001224600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895291" evidence="2">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001224600.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17531" checksum="11BAB7F570C62B01" modified="2015-12-09" version="1">MHFMKYLTIIVLLAVQYSFQNSSSESSLSSSSEEQQITLSNEEQPSSTEISNNGGPMDVLPENSPKQVVDKRRLFNSFSLKKSLRNGAKKLKVGAKKATKKGKKLMGKMFNGLKSSLKKLSSKKKRSTSSSSSDSDSSEDQNDRQKRFLVIEEDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2S0</accession>
    <name>A0A0N5C2S0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NIDO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2S0"/>
    <dbReference type="WBParaSite" id="SPAL_0001228100.1">
        <property type="protein sequence ID" value="SPAL_0001228100.1"/>
        <property type="gene ID" value="SPAL_0001228100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF64">
        <property type="entry name" value="DENDRITE EXTENSION DEFECTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895297" evidence="3">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="124"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001228100.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47064" checksum="9A41FC1526A264FC" modified="2015-12-09" version="1">MKPKEIFFILLSITCIHAIENSVTRNNFKYAGHRRYKRTLSAQKRESGLDLNVTVPYIFSARLYPYGKEHNDYEMTKNTEDLFLSTPLYLLGIQYDRIFISRDGAITFNNHLIGEPKNFPLDDPLIAVYWMKSKNGKVWFRETRDPNIIESTRNEINIQYKYGKHYKPDSVVIITWENTQEIGTTSEEGNLFQIALILSEKYGTFVHFVYSKLSTNKDAIIGFHGEPGLHYFTLPGSGTEDAILLGDKSDIGIPGEWLFRIDADDQIYLCGAGSKGMECVETCSPNQWYMDCTRECHCESNTACNSDDGHCPAGRCNKGWRGAPICDRDIDECFENKHVCPPETPDCVNTPGAYICLCLDYNNSTKSCRSPVHTEKIGKQFDEKVSSHSFTSDSPHMNENSDNIINAIPQVILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3N0</accession>
    <name>A0A0N5C3N0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3N0"/>
    <dbReference type="WBParaSite" id="SPAL_0001257100.1">
        <property type="protein sequence ID" value="SPAL_0001257100.1"/>
        <property type="gene ID" value="SPAL_0001257100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001257100.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19398" checksum="48932A3B9D0886E2" modified="2015-12-09" version="1">MGVQCIICFESCTASGTNHAPYSTPCGHVMGKECLEKFKEHLNNNCFNCLFCRKEIIVNNCHPIHGFVPEIKNSVTKSESTCKKLKENFSFSKNFSENINGTIKIFDEHNGNILIAGEIPSLFFSSHFIKLIVTNGRKIYDISEYKLDIECSCLCFNKSENGVIEFCVGYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4D0</accession>
    <name>A0A0N5C4D0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4D0"/>
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        <property type="protein sequence ID" value="SPAL_0001281100.1"/>
        <property type="gene ID" value="SPAL_0001281100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF10">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="204"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001281100.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37682" checksum="ABCE48126AF21590" modified="2015-12-09" version="1">MVFAGIEGRRRKDMSELNYFNNETNILSKDFFGNNYNPNQFIIYAPIKGKQVFTRIKYGSEASFDKKGKTRTANKNLKTKNKKIIKVKEKSSYSMTTNENFELSKNEFPDGNELEYLSKSKGVLPIPRRPKFYNEDKIFLTNKTKQVTVKKKVLDFIERLTTTTFKLPTKSLTRITPLSIVSGKENFYDRENSFTTADEALSTCCVRKGISHDCQQLCSFKEISDKTLVQAVLTNKCPNGELKGVFECANNGDDHTKCCFDQNVHLINNGQCMAFCSKVSTPITDVLQYFICLQVFEKIKNCYISNLNLVNSHRMPSKLRNKSYELHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4W4</accession>
    <name>A0A0N5C4W4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4W4"/>
    <dbReference type="WBParaSite" id="SPAL_0001299300.1">
        <property type="protein sequence ID" value="SPAL_0001299300.1"/>
        <property type="gene ID" value="SPAL_0001299300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895458" evidence="2">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="279"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001299300.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48310" checksum="F9AB4E4EF8FA96A4" modified="2015-12-09" version="1">MKVYILLLTLINTLLSQEPPPLPLKRHSYVKAGNSPALYSKDHTHGNEVIPPQLPSKRFSYVIPNQNRVLRPQSIVNYSVKLYLARGMKFYECNRVTFSNQAQAEKYCAMLNKYELKKAEQNHRHHTSTIENRRKSLSRSNSDLTNRRNSISESSSFLRGSKNSFSGSKSSLSGISRSSLRQSLTESGNHLSPRRHSISGSNRDLSWERNSISGSTRDLSGRSFLSKSRESLNNNGIDNERNKQLHDKYTKQKPKSHQIWLRVWSSCSVECYSANYYDVYKQKVFTEINLYRQMHNALPIRISPKLSVIAQELADKYAMRQTLDVDKNSEYGILYEKSRIESAPTIIRDWYNTNEKYNFFLGKKNSKSARSFTQIVWATTTKFGIGVQHDSGYLYVVCVFSPKGNKKGEYKKNVHKWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5F3</accession>
    <name>A0A0N5C5F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5F3"/>
    <dbReference type="STRING" id="174720.A0A0N5C5F3"/>
    <dbReference type="WBParaSite" id="SPAL_0001318100.1">
        <property type="protein sequence ID" value="SPAL_0001318100.1"/>
        <property type="gene ID" value="SPAL_0001318100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001318100.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35039" checksum="E23FBF3F9765ED19" modified="2015-12-09" version="1">MIAASIRLHYQPRAKKDGKASAKTDKLRRRSQILPERSEDGSPIKPNNLLKVDANMRKRSGSVPALKCTLATIWGIKSSHVKALKVTWVRLCDTPRSNCKGIVAIVEKVFDKLELKDKSVKEVFYNSAFVDSVYEYAGRRRPSCPSINEHRPKCAAHSHCGLREHIHFFVSLISQVIKALDAEPQYIIEHINKVAIFHANLKQYGFRPSSFDRLGELLVDSLVVQETVRCFPEACKAWTILIAAITDKLRTPSSSLQGGSPICLFDSSTNLESINSLSSQYKSLSLKTPYFGGRQIPSRASSPNPMLITSGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6D8</accession>
    <name>A0A0N5C6D8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6D8"/>
    <dbReference type="WBParaSite" id="SPAL_0001350800.1">
        <property type="protein sequence ID" value="SPAL_0001350800.1"/>
        <property type="gene ID" value="SPAL_0001350800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001350800.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14851" checksum="14D06C842D9D1E71" modified="2015-12-09" version="1">MWIYCCVFVIFYHSQTIYPFQRSKSNTNVSYHERYGTKSLVNDAINDLEDCLPIFDKCLSWSDVHEDRLKICEDFYDIHIFKNVTQPRRMYNFVNKYVEVHRCWKIINVFTPHMDDFFYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C864</accession>
    <name>A0A0N5C864_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">V-type proton ATPase subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C864"/>
    <dbReference type="STRING" id="174720.A0A0N5C864"/>
    <dbReference type="WBParaSite" id="SPAL_0001411900.1">
        <property type="protein sequence ID" value="SPAL_0001411900.1"/>
        <property type="gene ID" value="SPAL_0001411900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033181">
        <property type="term" value="C:plasma membrane proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001411900.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9843" checksum="397DEC8E08490A18" modified="2015-12-09" version="1">MAVWMTLVSVSAFWLVIGFFGPLLIPNSPNKDLIRTMIILTATCCWMFWIVVYLHQLNPLIGPQIPVKTIKWISKQWGDAKLLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8H1</accession>
    <name>A0A0N5C8H1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8H1"/>
    <dbReference type="STRING" id="174720.A0A0N5C8H1"/>
    <dbReference type="WBParaSite" id="SPAL_0001421800.1">
        <property type="protein sequence ID" value="SPAL_0001421800.1"/>
        <property type="gene ID" value="SPAL_0001421800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421800.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15821" checksum="8970E21764944BA4" modified="2015-12-09" version="1">MINKKGAIKNISCTSTLFGCNVHLTIIFILSIVAFQLSNVTEGKLNKWDQASALWGKRSSNALLYDFDYQPDYFLTSGYYMAKRPATNWQQMNSLWGKRSSKWDNANALWGKRGTWKSADGLWGKRASTWNNANGLWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Z5</accession>
    <name>A0A0N5C8Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUFIP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Z5"/>
    <dbReference type="STRING" id="174720.A0A0N5C8Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0001437800.1">
        <property type="protein sequence ID" value="SPAL_0001437800.1"/>
        <property type="gene ID" value="SPAL_0001437800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001437800.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="76741" checksum="699FA31F7E64D128" modified="2015-12-09" version="1">MTDNNGLTTNNNFNNMSSDSSKYNMDNSMGSFYPNQQYNQFNSQPNNQFSVPNGQNNYINSQMFSNQNNSNQNDNMSNTQLINQSRSVYDMSINKQSSYPQQSPTPNSANNMNNYSSNMNLPINNNNTMHQHSQIYSNMSFVFSSDMANKAICEINEKKYDNFKSWHISNYGHPNQFSNDKKLEQNCSRGVKRKMSPIKEQPNSSFTKPLSIPSTNGIHGQDGSGNILQNNTYGNLSTSSRTYNKDDDNPLRRMERMTQETLNEPPNKIPIRGNNPPLNGDNSLSYDQKKSQEKHLKLEKLNQIEKVFGIDKTRQKEESYHMNHMLHEQDMNKFPQGPMKNPNGFMQGVPMNIQQGMHQNIPQNMRQNGPPNLGPPFLPNTNMPPQNRPGSQPMPGNQRSHPQQQSPSVPFFPPGQNLQNRMNQFPNQQQLQNPSQSNPMMPSPQMYPMGSGGQQQPKQFIPPSSLPQQNNMRQMPMNGMQQPNMPPNINQSINPNMTQMRQQNMSTNINPNVNQVSMPNGIPNHSLQQKMPVPNNMNVINGQNNRPQNLQNPGMTGSGMQIPGLQGPGLQSPNIQNNNLQNSGIQGPGIPQQNRPQQNMPPPNMQLPNSMGSMQKSQQQQNMDQMMIQQNQNNQRFLPNQQIPNQMINGQNGMVPQGNEQSNMMRPNYDMSMIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C968</accession>
    <name>A0A0N5C968_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C968"/>
    <dbReference type="STRING" id="174720.A0A0N5C968"/>
    <dbReference type="WBParaSite" id="SPAL_0001445100.1">
        <property type="protein sequence ID" value="SPAL_0001445100.1"/>
        <property type="gene ID" value="SPAL_0001445100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001445100.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37612" checksum="722B4003671E745F" modified="2015-12-09" version="1">MEKANLVNTCINRENENDDDNELCDLGSNISLHSGVFRYNNNKFSNNISKDSHSHQNINPTQCYCEPSSIKDSINCKCDSTMYNSNINKELLSSRISASLNEGIDMPKYLLGFDRIVRKDIASENSRSLQNLEYVHALQKGRMKNRSQWFLDGNTNGNDKSDGNKPNKANIFNENGINNVKTNNDTSIAANNNIEDDQELINGETSKAIKKFNKKTPLAKTLSDKPILLPSLCNSTSGIERRSSWKRHYFRAQKSLDLSIESNNNTDKVLSSRDDKPIRRISTLTGFIRSTTNEDDNQSKSNKTKLVRRKSSSSMKNKSPSYYSTSKLVLTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA49</accession>
    <name>A0A0N5CA49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA49"/>
    <dbReference type="WBParaSite" id="SPAL_0001477500.1">
        <property type="protein sequence ID" value="SPAL_0001477500.1"/>
        <property type="gene ID" value="SPAL_0001477500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001477500.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="17311" checksum="D0190A8F545A6698" modified="2015-12-09" version="1">MKNINSTIKEMLEYEIESVARKCLLCNEISECMTKKRMIRKYPKYLFVELTKNIMDEDYLNMSIDFISSKDSVYVNEFFTPNTPHKLKGFIAYERFRRITGHYVTYIRYEDKWHCLNDSQKPKEMDENELPTERSTVLLYEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA56</accession>
    <name>A0A0N5CA56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA56"/>
    <dbReference type="WBParaSite" id="SPAL_0001478100.1">
        <property type="protein sequence ID" value="SPAL_0001478100.1"/>
        <property type="gene ID" value="SPAL_0001478100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001478100.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40247" checksum="620FC0C8E85B883D" modified="2015-12-09" version="1">MVQNELESTIYDDAHILMEQKICVKYVKTTRSASLINATLIKRGNKCSASADLVGRHVSFTVIVNSDCNTMSRIQKLIYWSLYMRYEFAKCLGNKQGHIIEKKMANVIKKYNCSFDKSETTTTISEFSVEYSYFSLPKVDGIEPKTLRQIDYSREFSFHEIKDLNKKICQNSCKKSKISCKNYSYKNPKKCNECLCPYFYNGYKCQNFVKSQHPKLCGKGSLTAQRKLSKMSLNLEVGCLYKVKAKNKKRQIKVTFKFDQPVFWDCKIYRNLEIRYRKDKSETGLIPCGNMSKFSVTGSYGGYILIYHPKLYSNRPRKIIMEYYELKTKMSKIYKEKKFKNFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAQ9</accession>
    <name>A0A0N5CAQ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5CAQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001497800.1">
        <property type="protein sequence ID" value="SPAL_0001497800.1"/>
        <property type="gene ID" value="SPAL_0001497800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497800.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40291" checksum="1B9E58F576B8C365" modified="2015-12-09" version="1">MELKKCPACTDTCSFSKSDSFLKCYSKKDCETNSECVQLDQCYNKAKTTKKPTTTTGKCPPNENWANCRSACEPNCLDNIKKPKPCPRICKPAGCQCIEGFVRDDFTKKCVKREQCPKTTTPFPTTTRKCKNNEIWNYCGSLCEPKCSDDPKKIKPCPLICQVGGDCVCKKDYVRDEVTGECVKRNKCTRTSTPLLTNTPTCLENEHFTRCGTTCPSTCSNYYKKPQKCTKDCFVGCECDEGFVRNEETNECVTPKKCPRNVTHDCPENEHFDECGTACPITCNNYFDPPKICTKQCIVGCQCDKAFVRNEDTGKCVPGVECPRSTTSNLKPHHVIQKTWFTRIANLLPNQDVEHLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCH8</accession>
    <name>A0A0N5CCH8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCH8"/>
    <dbReference type="WBParaSite" id="SPAL_0001558700.1">
        <property type="protein sequence ID" value="SPAL_0001558700.1"/>
        <property type="gene ID" value="SPAL_0001558700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895947" evidence="1">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001558700.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="54167" checksum="A3EF930ADDFA15A5" modified="2015-12-09" version="1">MKKNHINYFTLLLQLLWLLKVYANISMKEDGNKPLNGEINNVKEGSKYHNNHIVYKDIFSVVEDVFSANITETDSKDEKIFKDIIFSVPMKETIQIYNQIKEKYKTLSNVTMKTKNLMKKENKSNGIFNLTSPSPIHNTTTNTVTSSIMKLTRKLSNKKDTLTTMSSGVIRKNDSIMSKNETSTCFRTPFEKTKCIELFQLPNNNNYLVPKYKFHTCSIGKNFSAYITAIFCYLFNQKKFKYIYGHLENGIWNSFPCHNVNGPFSTKEVIKDYTNRDGKEFWERWRHVVIIRNPIDRFLSAFTHLCATKNNKNRKKDCFNCNSDMKCFLKRLYIDILRVKRKKKLVNNRVKNHFYPQTALCDYTGKNQFIRYLNFSTTKEIFYTNFIKELEDSNIPDNDVFFIEVEIRERILKHTTTGTKLREIQVEKLFNDPYLLDLATKIYYHDFIAFNYSLPNIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE66</accession>
    <name>A0A0N5CE66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HRDC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE66"/>
    <dbReference type="STRING" id="174720.A0A0N5CE66"/>
    <dbReference type="WBParaSite" id="SPAL_0001615700.1">
        <property type="protein sequence ID" value="SPAL_0001615700.1"/>
        <property type="gene ID" value="SPAL_0001615700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="3">
        <location>
            <begin position="498"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001615700.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="87806" checksum="08C798425DCA80B2" modified="2015-12-09" version="1">MEEESAEHFPYIRAPALKHLPEDFKINEDRLLDELRNIKSEEDREKFRADYIKFYNSSINLRKVVARLASLSSLIELDSVQFYQAKTTPQFRQLLKAMKAKFSKIFDEVCSSSFQHKYSMIDINDDDCRMELVNRLVGASKKARYQLNVDEQGIKNKIQCRANLSNLDVATGSRNKRNRTDDIALPTIAPNKKIRRIDPTISLLTASRKPQEDFKECIINDDAPFINKLKIKHNAKVEWKNTINDENELSKHPYMYELKSLEICNDLLREQILVDVKPLVDTPLVFVNTVQSLEEIIQYLKMQKEFAVDLEHHSLHSFLGITCLIQISTYEKDVIIDPFPIWRDMWKLNDPFSDPNILKIFHGAKFDIIWLQRDFGIYVVNMLDTQCVMKILNISPLSFASLVYRYYSVELDKKYQLADWRYRPLTYEMTQYARSDTHYLLGAKNYIVNHCLRAGNKNNNLIRAAYEDSILLCMNHFEQPRLEVEIYGSFKKRFELFSPLQKLVLRRLYRWRDEIARVEDESLEYILAEDALYSIVECHPIDVQSLLCTCVPTPPYLLKHANEISSMLYKMREYSVDECEKYLEEEEKNFIGSGSRNVTYNILDINEMRMHAMFNKMDYSSEYNMNKISKTICIDERLSDLPLFDCSVTTDTSLYKKFKKRIYNEGKKVIVEAPFYLKNCLEDIVPKVVENKIIEIHKKHQDWVTPYEKYCMGIKLLEELKPDSEPSRDVRIAEEKMKSAKSWAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF43</accession>
    <name>A0A0N5CF43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 18 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF43"/>
    <dbReference type="STRING" id="174720.A0A0N5CF43"/>
    <dbReference type="WBParaSite" id="SPAL_0001648100.1">
        <property type="protein sequence ID" value="SPAL_0001648100.1"/>
        <property type="gene ID" value="SPAL_0001648100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001648100.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="52807" checksum="C75E765D1C561F5B" modified="2015-12-09" version="1">MDVDTTAKKTVKRMLTEEEKEYQEKLTKKIFLDQHFLSSSESDEDDDASEKINKVEKKASVWEDESSNDEDDSIKKKKRFRENYVKNNINKYSWAKKKEPNLDGHSDSDDDELDKASSMLSKKAGKYIKTQKGLGVKVINFNQIKDISLGYHTSKPVASVKFHPSKPVLMVASSKGKISLFKVCEADNLKKIEKDNYLQHISIKNFRLINAEYFAGGTKIIASGHKSSCLYLYDILNGTVDETFIPKSIKRFSSGQFTVSSCGTLVALLGDVSEVYILNANTFEVVATFIASSRVVSATFSKNTRNEIYGFTEDGNVYIWNLTSRSEQNAFIDKGCVHGSKIAISYNDQFLACGSNTGFINIYDVTRAKIADFASSLEPIHTISNLVTAGDILSFNNTSEILAYGSTSKDMQMRLYNIGSGTTYENFPHISEMRSRTKMTCVDFSPNSGFVVFGTRNGGLKMYRLNNFTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF64</accession>
    <name>A0A0N5CF64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF64"/>
    <dbReference type="WBParaSite" id="SPAL_0001650100.1">
        <property type="protein sequence ID" value="SPAL_0001650100.1"/>
        <property type="gene ID" value="SPAL_0001650100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001650100.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="35230" checksum="5B92D8FBCF51FAA7" modified="2015-12-09" version="1">MRVTCRWCRINNCKRFQCQKFGKLNIMADIDTEELPRTFRIPETIEIDEENVATTSNFSKPNLTPKKVSSISEVSIYHKTPLRRPKIYKNYMHKETIFVRNIREARSPCWLKRSSLSSIRKTTNRGRNICVTLRKNYIENIIEFVRNESKMYSNDYPLYDIEEEYEEDVEKSERNPQYCNTFSSQVVNSSSPKIVELDEHGNEIVDTSVTSSINAFNNLSLENGIEKTWQNYRCIDLSEKSDNYNNLLDFRENMLICGLQSLHIPDRNNGSIVNERDFFESSIDTITQKLVKTLDMSQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFC9</accession>
    <name>A0A0N5CFC9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoplasmic reticulum transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFC9"/>
    <dbReference type="WBParaSite" id="SPAL_0001656500.1">
        <property type="protein sequence ID" value="SPAL_0001656500.1"/>
        <property type="gene ID" value="SPAL_0001656500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001656500.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11362" checksum="DE94B72E6A21162F" modified="2015-12-09" version="1">MIVCSNVTLNFVCVNSLNRIYGEENSFGVTGLTITVVVLIVRAVHVAVEFLYKNKSRENKLLKIATLTVTKSEPYDIKIKETQQLSVGERRGSEETAKLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFU1</accession>
    <name>A0A0N5CFU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFU1"/>
    <dbReference type="STRING" id="174720.A0A0N5CFU1"/>
    <dbReference type="WBParaSite" id="SPAL_0001672400.1">
        <property type="protein sequence ID" value="SPAL_0001672400.1"/>
        <property type="gene ID" value="SPAL_0001672400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001672400.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34045" checksum="D0262B558E691EC3" modified="2015-12-09" version="1">MTLSFIFLFFKAALGFLFVIKYIQYIVIIIDRTSSELNRSLIRIKYEKEDNFDKSKEINNNKEEVYDNNKLGNYVDGSSNYSISEFTDDSRLYSSSSMTYSNYIRRRSRIPKYGTPLLKDGKSTTQYTPFDNRPPFKKYTTPTGLNSNIDYSSDLKKIENQIQSQIKECSCSPKFKVKKLSDNNNVIFYEFGSYNTLKRHVRIYNSTVSIRVGGGWVSLEDFFNKIDPCRMAKKRYSQYNVISPVLTQEKMRSYSSETLLTSCMPLRDYNTPETPLRRPRNNNYTRIKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG14</accession>
    <name>A0A0N5CG14_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3106 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG14"/>
    <dbReference type="WBParaSite" id="SPAL_0001679300.1">
        <property type="protein sequence ID" value="SPAL_0001679300.1"/>
        <property type="gene ID" value="SPAL_0001679300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895823" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001679300.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15738" checksum="DB3B0D54D32BBA7A" modified="2015-12-09" version="1">MKLHFLLLLSTSIICCILEVSSYHLSVSQISDLNPRPYQTTSVYETFKYEERKDMWDRIKYQLKKKQNLPTVEDKPTFLRWAWELIFPSSVTQYDKMPLPSYVKLLALENLLKNTKKPFNIQDINYVLNMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGC8</accession>
    <name>A0A0N5CGC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGC8"/>
    <dbReference type="STRING" id="174720.A0A0N5CGC8"/>
    <dbReference type="WBParaSite" id="SPAL_0001690600.1">
        <property type="protein sequence ID" value="SPAL_0001690600.1"/>
        <property type="gene ID" value="SPAL_0001690600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="330"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="870"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001690600.1"/>
        </source>
    </evidence>
    <sequence length="904" mass="102424" checksum="48546777E64AC5D1" modified="2015-12-09" version="1">MGNLDFVKNSITEMKSEKKPLLNSKTNLSFNNKLNADKLIYELVESLTPSSSVGGQLPGKSFNIEVVNKNLSSSPSPGAIGTPSHFLPLEQQVCPALIYSEPALNENFHNYEQPIRISAFSETALQHLYDQDVNDDVPPSENTSSFDVNRIRRNKKNLGRESVVQSNATLAYGESIQSVITTATLTTGTNQHKQSFSTREIREQHMEIQKKYRPSKKRNFTDPVDFEGILNIIGGCSWWQMWVYLLISFQQIPHAMFNLNVVYMMYQPDHWCQVDGFEDSYNSSIIYKWNLTDAMNTPIVFNQTNINQRDINYYHDQCKYFDRGPERYRQLRQMSLKDAILDIEREKNDPNYKPINLTKCKKWMYADDVMTRTIVTEWNLVCEYNFHRAHAHLFYAFGCLVGCMLGGAASDRYGRKPTIVGFGILSSIFGLILPYSTYFPMFLLFRFCGAICNEAADLAAYILCMEVTGTRYRAMVGSLLQAPWAVGYAMLALTAYYCKSWQHVQLITAALHTVAVCLICVLPESPRWLIVNNRVEEAERYIRRACQEPPFPFSMCIFNKSSLPCDLELVKHAEQRQWIQQNQRANLFHVFKSKALCVRSIVICIVWVATCLVYYGLVIAFSDQSSPGKILFSGNFFINNAIAGAVELPTLIGCVYLMKYGRKRAQMISLIGAAILIFIAMIAVHNESHDIAIVTMLGGKIFIQGAFNILYIFTSELYPTVIRNSAVGFNSMIARFGSGVSSYIAILSDVTLPIVPMMIFSCFSLFAGALVLILPETLDRPLPDTLQDAVTFLKNDDKYHCYSFGISSKKQTSANNLGEKSSEKESDQKEKNEDIDDYLPIAHDTIKELPDVSMGKRRRRLVNTGSRRLSSDFMSQLSSRNTSSSLNSDLKETDIPEHLNELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHG7</accession>
    <name>A0A0N5CHG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L54, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHG7"/>
    <dbReference type="STRING" id="174720.A0A0N5CHG7"/>
    <dbReference type="WBParaSite" id="SPAL_0001728400.1">
        <property type="protein sequence ID" value="SPAL_0001728400.1"/>
        <property type="gene ID" value="SPAL_0001728400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001728400.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18422" checksum="432D747D365E8382" modified="2015-12-09" version="1">MNRLFQVPSYILPRTANIITRTVSTTQTLLGPKVQAYKVDKSFVETDAEKLCKYVCINYLTEVKEPGPEIKPDSEYPAWLFELDLSEPRELEDMDPDVDGWMYYRTLLKRYHEQNRRIRKLKARFLHIQDSPSLKYVDGNTKRARFTKKSHPFNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHK3</accession>
    <name>A0A0N5CHK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHK3"/>
    <dbReference type="WBParaSite" id="SPAL_0001731800.1">
        <property type="protein sequence ID" value="SPAL_0001731800.1"/>
        <property type="gene ID" value="SPAL_0001731800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895946" evidence="1">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001731800.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18656" checksum="B6E00AE600CAA193" modified="2015-12-09" version="1">MRVFNTSKIFIIILISNIVKICTKKVEVRVTATPMCIGGLFTGTSEDVKAELGKLGMKGHIKPKNTTDGLCNYRITNHANFTESDIKNSDIYVNYTYTSSHRNITKKIPDDCKDKDDYIQQDFDNKYHFLCNLGYLDPNPKNESENTTPVSGKYPSLLGNCGCCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIG4</accession>
    <name>A0A0N5CIG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001762000.1">
        <property type="protein sequence ID" value="SPAL_0001762000.1"/>
        <property type="gene ID" value="SPAL_0001762000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001762000.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21807" checksum="7595D66D9AF28EBF" modified="2015-12-09" version="1">XKDYQYFKGITRPFRFNDYKHIFYYYCNATQNNDCMYGGYKLEKSITSSTCKCPEYLNGTKCEKIFSNNMNCTKLEQNITATSEKQFFNLTITQGRCYFNITSQSGKNISVTIESLAFNKTNCLSGQSFLEVLVRNDKGAGGINFCNNTKNKLLPALSNQVFLVFSNGDQNLTFNVSYVEELENNLNGNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIL0</accession>
    <name>A0A0N5CIL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIL0"/>
    <dbReference type="WBParaSite" id="SPAL_0001766500.1">
        <property type="protein sequence ID" value="SPAL_0001766500.1"/>
        <property type="gene ID" value="SPAL_0001766500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001766500.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="42100" checksum="2FB03F1598A01282" modified="2015-12-09" version="1">MYLFTETIFSQCPHENYCVWMSILGIILFPIQVSLAAFLISHYKNTKSEYIQFMAFFRIISAFLFTFQSIVVEIRTFFPRKTIICYGLVRFLGDTFCQLSLVCAMVYIMLEFCIILFAFNGQYNNICRKTGFYNNNWIQNTSFFIFFITIVAYFTLFMFSFIPREEGISKLYMKHNDMKAFANGSYIIVAIGESKENISNGIFIIAAIYLVHYITHFSFVFCKMGRFIFEMKELGKNSSLRQSYINKFIHHLINVSIPMVIVFIPLVNLCLCFFVFYQEELYWLTKVTTNSIMFCFYINEIVSPFYTFYFILTSNKTKIKIILSSKITKVLKKKNSNRNLFMKKEITKIENFKCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIZ9</accession>
    <name>A0A0N5CIZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001780600.1">
        <property type="protein sequence ID" value="SPAL_0001780600.1"/>
        <property type="gene ID" value="SPAL_0001780600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001780600.1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5756" checksum="FD598C32B27AD699" modified="2015-12-09" version="1">MLTEYLHLVYSFESPLGSVGYINSYGLFYILEYVLPGASTLFPLKLLRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2Y2</accession>
    <name>A0A0N5B2Y2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0000043300.1">
        <property type="protein sequence ID" value="SPAL_0000043300.1"/>
        <property type="gene ID" value="SPAL_0000043300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000043300.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9874" checksum="8DE65752EB78EE07" modified="2015-12-09" version="1">MSKFKTINKDHGFNIRDQVYKKLLDRVGNTMKLETRFKGPYKLMNIDEETGNCQLQSISRYGRENEKKLVTAHIKQLKLDKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3I0</accession>
    <name>A0A0N5B3I0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3I0"/>
    <dbReference type="WBParaSite" id="SPAL_0000063300.1">
        <property type="protein sequence ID" value="SPAL_0000063300.1"/>
        <property type="gene ID" value="SPAL_0000063300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000063300.1"/>
        </source>
    </evidence>
    <sequence length="755" mass="87343" checksum="4812BF84D1F4C7BB" modified="2015-12-09" version="1">MSKNICSICGSKSILFNNIPEFKEHVHTIHKCGGVTIGKLSFRCVQSFYRTLTSDNCNCKNTGIFTFTSILRHYQKMHNFGSPENNPLHEVISNTNEISINNDENLYDTENTSMDVDEMNANIEEATNEILNDLISTSGSAIEFARIQATYDFLIKSLNVLKKVTKCGFIDEFQKVLEPISTQYKREQYLMKKKVFIKPIVRYAVGDNLYPYHCFSMRERLVSFLSNKYVQKQLVLKMPKRTQARKYSCLDGNRAKNIIDRSKKTIFLNVFQDAMSPRGICSVSKGSFTMIYLRLANLDPIYGSQLNSIRMICTANSKIWKGTKFRYPLKLIVSEMNDLIDNGINICVDGNMENFAVRFLTFSSDNLELNQAMGFFTDFASRNTDTCRLCETTNTNFKNVFSEKDCILRNELRESVLNEIHGYNTLVPYLDVCHDILLGVVPNFIKIFFSRLVFYYKNLKLKPEPTKGYNSLQNLYSNLKYGNFQKPNKIGKIFRNYKDTKLFQSAMQSYSLLIFLPMVLNKLKNSCDPIEQILEFEEDERILTNVIRLTYLTMSSSIHDVEIKKIEDELVPSIIKYFRDKEDLKPKTHNMVHLGRAFRELGPLKNISAFRGEAFHVLCRNDVLRSKNKVEEAKTIARKNAYRECKMKLQDYGASAIKKYIPGKDDIIYLEKNGNSYGYNVIKVIDSDATKVHGFKLSLKHCYGSLFYFSITEEEDFYDCSTILSTECEYHIYKEKNCSNYNSDLLVIFNSYICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3P7</accession>
    <name>A0A0N5B3P7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3P7"/>
    <dbReference type="WBParaSite" id="SPAL_0000070000.1">
        <property type="protein sequence ID" value="SPAL_0000070000.1"/>
        <property type="gene ID" value="SPAL_0000070000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893942" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000070000.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15615" checksum="1F88442176C691D0" modified="2015-12-09" version="1">MRFLLVQLFLITFICLTISAKKGQIKKPRGLQNPLHDDYVRCKEECKKIEEREVTEKYIQYLRTELEAAELVAAQEQALLQSTISTQTGNQNVNNLNNPITENDPSTMIEATQKETTEVVNEVQKETFAQEENLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B533</accession>
    <name>A0A0N5B533_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B533"/>
    <dbReference type="STRING" id="174720.A0A0N5B533"/>
    <dbReference type="WBParaSite" id="SPAL_0000118000.1">
        <property type="protein sequence ID" value="SPAL_0000118000.1"/>
        <property type="gene ID" value="SPAL_0000118000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893906" description="Glucosylceramidase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="104"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="455"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000118000.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59801" checksum="55FA8BDA1171FAD7" modified="2015-12-09" version="1">MLIKIYLLYILLNIVRALSEDKPCSKKNFGDENDLKIVCVCNSTYCDESSDFLSTQLISNIGIITSTKDGKRFEKTFQVKGDSLNDSEIHGIINIDTTKQYQKIIGFGGAFTDSFGINMNTLSSGAQANLMNSYFGNKGIKYTIGRVPMASTDFSERIYSYCDTENDFELKTFNLTEEDFTLKIPFIKKAFQLTNNNLKLFASPWSAGGWMKTNGKMKGGAPLKGEIPGPYYETWGNYFVKFLESYYSQDIQFWGVTAQNEPTSGLDPFYGWQTMLFTPETQRDFIKLYLGPKIKNNPKFKDTKIMILDDDREVLPYWADVVLEDNETESYVDGVGIHWYQDEFPVNNIKKTYERHPTKFLLATEACNGWFGLDRGGKPGYWIHGEAYLFSIIDDINHYVSGWTDWNLALDMTGGPTWAKNNVDSPILIDKSKDTFYKNPSFYAMAHVSKFVRPDAFRIDSVMDNKINEFDFVAFKNTDGSKVLVILNKSERDLNIKINSISSNAVNIGVVRVEKYSFKTIVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5A8</accession>
    <name>A0A0N5B5A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inhibitor_I29 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5A8"/>
    <dbReference type="WBParaSite" id="SPAL_0000125300.1">
        <property type="protein sequence ID" value="SPAL_0000125300.1"/>
        <property type="gene ID" value="SPAL_0000125300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893979" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000125300.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="21130" checksum="F0E7966AFC68DA73" modified="2015-12-09" version="1">MLFAFCIFIFILYPCLQSFEDKKLSFSSYEKMINKDYIKALVDEAVNRLQQTYETENLKYKKSAQEYKKYIDEKIEGHEVKKISLQKKHMDLRKKYSKMNEDLFGNGNFIESPEDYEFEMKDKKYQSFEDILSKNDTTKKFPDQPILEQHQKNMRSKRTIRKISKIKLKKVNSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5T8</accession>
    <name>A0A0N5B5T8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5T8"/>
    <dbReference type="WBParaSite" id="SPAL_0000143300.1">
        <property type="protein sequence ID" value="SPAL_0000143300.1"/>
        <property type="gene ID" value="SPAL_0000143300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029162">
        <property type="entry name" value="InaF-motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929:SF1">
        <property type="entry name" value="INAF MOTIF CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929">
        <property type="entry name" value="ZGC:153157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15018">
        <property type="entry name" value="InaF-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000143300.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23931" checksum="4FC4B8CDB71C3F0B" modified="2015-12-09" version="1">MSSLHARSSLSGTNANMYSRPRSRSRQPIYTSDKRAKFAQRENKKYIRFVTVIGYIFCVSLPAVCLSIYYINFWDPRYIDKFTKINYPPINTSDKNIRINDDKLIATSRVKLLKKELPRKTRDNPLEYDETIYGLDNNTSNNKIFDKIIENGQILPTDNMEENKENYSKKIIKEMKKSGCKCTCPNDSTKDAKKSTILNMVLSGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5U0</accession>
    <name>A0A0N5B5U0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5U0"/>
    <dbReference type="WBParaSite" id="SPAL_0000143450.1">
        <property type="protein sequence ID" value="SPAL_0000143450.1"/>
        <property type="gene ID" value="SPAL_0000143450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893783" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000143450.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10609" checksum="D7FB6FC1F1B5C963" modified="2015-12-09" version="1">MYILTLFLFLLTNLLSLTQCIFKKKDRKANKELSVKREVIDYNNQENDFINQMVDKENNRSSVSGVSGVSGFGTNVSYINGVKSSVSPAANRNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6C5</accession>
    <name>A0A0N5B6C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6C5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6C5"/>
    <dbReference type="WBParaSite" id="SPAL_0000161500.1">
        <property type="protein sequence ID" value="SPAL_0000161500.1"/>
        <property type="gene ID" value="SPAL_0000161500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893953" evidence="3">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000161500.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43248" checksum="C4F267A7AFC00DAA" modified="2015-12-09" version="1">MILATLLLPLFYLSTTNGDDTLLGVQVLWRHGARPPEVIFDYDPHKNDWPVPLGELTPLGMRQHYDLGKRLMQRYGEEYKLINTSYNVGEIYVRSTDVNRALASAYSNLAGMFSESKNTYPDSNWPSQWTPIPVHTVPDTDDNLLNPTFYCPRLYQLSDERLQTKQFLIFENTFSSLFDYLTLHSGANITDYKSLETLYVTIRVEKYFNYSQPSWVTDDIFKQMESFVNSSINYSYGCAGFGLPEDTELISLKGGHLVWQMIDNMKTIKNNGKIEKYIAYSAHHTTLISFANVLGAKVKIMGQGLIDFAASFILELWKDENGNYYIKLFYANNAYGDFTPVTHLIRGCINQDKCSLDDFENGASAYLQHYPQDHCTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6H6</accession>
    <name>A0A0N5B6H6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6H6"/>
    <dbReference type="WBParaSite" id="SPAL_0000166500.1">
        <property type="protein sequence ID" value="SPAL_0000166500.1"/>
        <property type="gene ID" value="SPAL_0000166500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08554">
        <property type="entry name" value="Cyt_b561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF50">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="57"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000166500.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33209" checksum="6BE7169375D949D4" modified="2015-12-09" version="1">MSRNIYGNIVSTSHPYWDYSEENDDCCVGLRYTSKVDVNSLKIKQASLRIFDFFSTFNQLCGLIMVILIGFFYGNIDGSYYWKDINSTTLTPDQERAYLNLHGLAVIVGLVFFHGEGLLINRHYRHEPRLIFKVYQVIFNLVALACGGFALAAFVVFSNKQTDYQYYSFQFWLLLGVLAIYVIVSFVYLFVFTFPRLPKKYRQIIRPYVNAMNLITFVLASVYSILSNALYINKYVNKQSSNICQNDGDCVTNFEYVMNFGLVATVLYSIIVVVQVSKPSWSRKVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7F0</accession>
    <name>A0A0N5B7F0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7F0"/>
    <dbReference type="WBParaSite" id="SPAL_0000197600.1">
        <property type="protein sequence ID" value="SPAL_0000197600.1"/>
        <property type="gene ID" value="SPAL_0000197600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894003" evidence="3">
        <location>
            <begin position="22"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000197600.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51454" checksum="8BA84F4C050CD8CD" modified="2015-12-09" version="1">MFVNKNILFVTFAIFSTVVEGQISPIVPINSQYSYGLYNPYTSMNGYSSYYNRINPYSSLMYPSSLLSPISSGYSNYVDGISSLGYLNPSLNSLMYRNGISNSYLNSLSSGIPSSYMWNTRYGLGGLSGISGYEGSLTPNTFSNYIQPDVSIPPLGVPDSTSLTRNLLTSQYIPGSGSGMCKDQMTQCAVYASTGQCSSSPILMTKLCPISCGIGCATSDIGSVGVNNLNTISTMASIDSPFTTLPTRLNGGYLDLSPSNILLTPVDHLNSIPTLDHTSIIYDSVASYKFDNIMKYLNALYSRFQNNINILPNLYNYENSPKISSSLLLPPIINSDKDSHYLLCKDSHVDGCPSWSAMGYCSRFPTFMNTYCRGSCNSCENKNTISNGILVNDKDFITSFSGGYGSYSPYINSVRSGIYPLTERKPSTGNNNGIPSLPTLKTNNNDEDLLHISRKQRTNRLRELLEMSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7J4</accession>
    <name>A0A0N5B7J4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7J4"/>
    <dbReference type="STRING" id="174720.A0A0N5B7J4"/>
    <dbReference type="WBParaSite" id="SPAL_0000201900.1">
        <property type="protein sequence ID" value="SPAL_0000201900.1"/>
        <property type="gene ID" value="SPAL_0000201900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF27">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="114"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000201900.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27785" checksum="5A4581E8EC7C2122" modified="2015-12-09" version="1">MDNIKWLEDHYCCYVIDTSTPDALEKSFNAWLKSTPSEEYNNSCYQLQSTVGNPYYDVTKEYPNYYFNNISYFNYPITNDSSMLNNNTTTELSTNISTTDTEKRPPRKRNNHRRTSGTNLYGRPYCPGRPLSMSERCRIIELHRQGMKVNAISKALCVSHGCVSKIISRFRETGLLSPFSNSENRRNRKGMKNSNNNLNNNNNNNNKIAIVDKNVNRSLQDSCDTFVIPSNIPSDRQIASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7V9</accession>
    <name>A0A0N5B7V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7V9"/>
    <dbReference type="STRING" id="174720.A0A0N5B7V9"/>
    <dbReference type="WBParaSite" id="SPAL_0000213300.1">
        <property type="protein sequence ID" value="SPAL_0000213300.1"/>
        <property type="gene ID" value="SPAL_0000213300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="3">
        <location>
            <begin position="90"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000213300.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37014" checksum="2C0D4C963E8067F2" modified="2015-12-09" version="1">MLDNKEYISDVEIGSDIINTLPPEIIFKIFNYLPAKYVVKQCSIVCKNWKTIIQKPQYWINRSLNEGCREVLPPAEIVNDPIYEWNFAKLFILRPFNRNLILNPSGEFGLEGWDSQRREERFQVERPGGSLESVFPTLETCFVSSYYECRKYCDIDLRDYGLSRSFLDRFKPTIYVSEMNSYRKDAAAFYSLRIQLHPGNINLDRSNHFRVKNNETTFTYKKLVDQWTDPVWETIEHNFSGYPSGCHQIFFDTIGRDNMFWAGNYGSKCCNATIIVKYEFNKPYEKVEESSDSQGDEVLDVEEPNDNQGDDVLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Z5</accession>
    <name>A0A0N5B7Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RHO protein GDP dissociation inhibitor</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Z5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0000216900.1">
        <property type="protein sequence ID" value="SPAL_0000216900.1"/>
        <property type="gene ID" value="SPAL_0000216900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000216900.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21939" checksum="43028FF2724A2EB9" modified="2015-12-09" version="1">MSEADKIDAKEFELPQNYVKPAQKSLNEILSTDANDESLVKYKEKLLGQNAENLVIDPSISSNCILKSIALEIDNDITNKVEFTKSQPPPGLSISIKEGVNYRIVFEFYVQREIITGLKYCQKTSRHGLPVDKESIMLGSYAPRPEYYTYKTTICEAPKGMLHRGKYKVRSLLTDDDENHLCEWGWQIEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8D5</accession>
    <name>A0A0N5B8D5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8D5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8D5"/>
    <dbReference type="WBParaSite" id="SPAL_0000230800.1">
        <property type="protein sequence ID" value="SPAL_0000230800.1"/>
        <property type="gene ID" value="SPAL_0000230800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000230800.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38457" checksum="BE13687A9769619B" modified="2015-12-09" version="1">MPRIDNEPKLDFKDVLLRPKRSCLRSRADVCLIREFVFRNSKKTYSGVPVVASNMDTVGTFTMASVLAKNNMFTTIHKHYTTEEWIEFANGCSRDKQIFDNIAISAGMASEDFTKLKAVCDALPELEYICLDVANGYSEHFVDYIRKVREEFPRHTIMAGNVVTGEMVEELILTGADVVKVGIGPGSVCTTRKKTGVGYPQLSAVLECADAAHGLNGHVMSDGGCTNPGDVAKAFGAGADFVMIGGLFAGHDQSGGDIVEKNGKKYKMFYGMSSDTAMKKHQGSVAEYRASEGKTITIPYRGDVSGTIQDILGGIRSACTYTGSKHLKELSKRATFIRVTMQTNEQYAAFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9D5</accession>
    <name>A0A0N5B9D5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bestrophin homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9D5"/>
    <dbReference type="WBParaSite" id="SPAL_0000265100.1">
        <property type="protein sequence ID" value="SPAL_0000265100.1"/>
        <property type="gene ID" value="SPAL_0000265100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000265100.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8432" checksum="4F2D52790FE73A70" modified="2015-12-09" version="1">MLLFIISSTLFYQAIRRYKNNEGCDEWVRLEENIGEYFSISIIYITTIIQIWNVGWNIKYSEDKFNVNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9F6</accession>
    <name>A0A0N5B9F6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9F6"/>
    <dbReference type="STRING" id="174720.A0A0N5B9F6"/>
    <dbReference type="WBParaSite" id="SPAL_0000267200.1">
        <property type="protein sequence ID" value="SPAL_0000267200.1"/>
        <property type="gene ID" value="SPAL_0000267200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="132"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000267200.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="62282" checksum="D1B42F0CB673DAA2" modified="2015-12-09" version="1">MLDQHSQRILANATDVLYHDFEPKDCVHFFQSKGILTDDDVEEIISCNRRHGRVDLFLNKYRKRCFNFILLREYFTNYVSQVHLAELLEDNIDVEVEKIEDPKILLGKMNCAQVPRSLTYHIRRFELEECLEKKLKQFINGDVDWLVVNGIRGCGKTLLTADVLRNNVEFLSKHINNIYWFNDSCEIISKSKQIFIKMLVSLTDTSCLQSSYPEDEDLIMGMIVEQIQSKAGKTLLIIDDILLEDNLRWYSKMISMLSNICKIITLSPNEEIFQALPQEAIKFSFKNNSGFNYTQIERFFTNNEETPSPFLINRLLEETNGLPAFLGILKFQSSNNISRLEKLVDRLESCNSLTPFTSITPYFYKNMNTAFDKDFCIMDDSDILNLCHLCILFTPNIWYHFAYATLILPLDIPSYNCDIPALVYESIEKLSKLSLLQIDGDKFMIHPIVFKYCIGKQCQYHQIDKECLVSLFLSRLNPIATGTGSNFMFKEFKGMSKSDAKKTYNQLKDYHSKRNDFEDSKKENVYSLFNFFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9X4</accession>
    <name>A0A0N5B9X4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9X4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9X4"/>
    <dbReference type="WBParaSite" id="SPAL_0000284400.1">
        <property type="protein sequence ID" value="SPAL_0000284400.1"/>
        <property type="gene ID" value="SPAL_0000284400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="158"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="385"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000284400.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56915" checksum="6117FB27D3FB32FC" modified="2015-12-09" version="1">MHYVYRNFSNIYGTSYLPIIFITLSFLIQFGQFKIYLNDERIPHWMVGNPNIGPDFSQPEQVHLSYGGDVTKLIVTWVTFDDTFNSYVEYGENIDRLDIIVKAKMHLFDEGKKRYIHTATIDNIVPGKRYFYHVGSKYGWSPVFWFYGLKERPDGGYKYAVYGDMGNKNARSLGKLQEMAQKHEIDVVLHVGDFSYNFDTDNGNFGDQFFRQIEPIAAYIPYMSVVGNHESANNFSHYVNRFTMPGTEDNHFYSFNLGHAHFTAFSTEFYFYTGYGWTQISNQWKWLNNDLRYANDNREKYSWLITMGHRPAYCSTWDGDDCRFFNSIIRTGLPLTHAYGLEKLFYENSVDLEIWAHEHTYERMYPVYNRTVMKKGPNPYIDPLAPVHVISGSAGCQEKTDIFVKDPGPWSAFRSSDYGFSIMQIHNKSHIHFQQLSAAEEKIIDDFWIVKNNKLGYHRKGALEKLLQEGETYLAPVEDNEVEQEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Y4</accession>
    <name>A0A0N5B9Y4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Y4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Y4"/>
    <dbReference type="WBParaSite" id="SPAL_0000285350.1">
        <property type="protein sequence ID" value="SPAL_0000285350.1"/>
        <property type="gene ID" value="SPAL_0000285350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000285350.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16044" checksum="6ECA3BE147A2B0DF" modified="2015-12-09" version="1">MIEEFVKNSKIKFGDGGKEFIEKLGRELKKLNYSPKNVHVISNMMEFNKDNICNSISEPVKVTLFHRLCDRHNILLLGDSLGDIHIDVGVKQKNVSLKIGFLNYEVYKLLSKYMEEYDIVIVDDQSMEVPNHILSLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Y9</accession>
    <name>A0A0N5B9Y9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Antigen peptide transporter-like 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Y9"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Y9"/>
    <dbReference type="WBParaSite" id="SPAL_0000285800.2">
        <property type="protein sequence ID" value="SPAL_0000285800.2"/>
        <property type="gene ID" value="SPAL_0000285800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18572">
        <property type="entry name" value="ABC_6TM_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000154">
        <property type="entry name" value="HAlF transporter (PGP related)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000140">
        <property type="entry name" value="Lipid A export ATP-binding/permease protein MsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="14"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="327"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000285800.2"/>
        </source>
    </evidence>
    <sequence length="623" mass="69673" checksum="D174AE5A0638E391" modified="2015-12-09" version="1">MQFVKREWIWHVSGFFWLFVYSLTRIFVPYYTGNVIAALVPGQGYAALIEAVKLMSALAIGSAIAAGFRGGSFEYGGARVARIIRNDLFTSLVHQEVAFYDVHKTGEIISRLAADTQTMADTVPLNLNVFLRNTVMCIGSMLFMMSLSWKLSLITFIVVPIIFVVTKIFGSYYDELSEETQDAIASSNDTAEEVISTMRTVRSFACEDFETQRYFDKLTYTLQITWKKAIAYLIFIWASEIFQTVIVVAVLWYGGHLVLTNRLKGDLLVSFLLYQVQLADNLRQIGEVLAALLQSVGASRKVFQYIERKPHIDMNGKYKPQEFEGKIEFKNVRFNYPSRPDLPILHDVSFTVEPGETVALVGPSGSGKSSCIGLIEHFYEPLSGKILIDNIPIEEYEHHYIHRKIALVGQEPVLFHNSISENISYGLDYCPEADIIDSAQKANAHNFIVQTRDHYKTNVGERGGNMSGGQKQRIAIARALVRSPAILLLDEATSALDTESEALVQEALSKNMKHKTVLLIAHRLSTVETADKIIVIDKGRVAEMGNHQELMSKEDGIYRQLVQRQMIGQSLESPAKKGTKTSRGDDSNISNYLLRDNSMAIGSRGMANSLLATSFSNSSVYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAQ4</accession>
    <name>A0A0N5BAQ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase_Zc3h12a domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAQ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000311900.1">
        <property type="protein sequence ID" value="SPAL_0000311900.1"/>
        <property type="gene ID" value="SPAL_0000311900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE REGE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase NYN" evidence="1">
        <location>
            <begin position="40"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311900.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40916" checksum="E94DE1F68B3F3465" modified="2015-12-09" version="1">MNNTPCVLKELYNKQVQRKLQRIVQNEYIFKPPCAEALPRIVVLDGCNIARGSCGPQREYFNCAGLLAAIRYFLIRDIDVMIFMPVIYLNNDNPFIADSHLLLELKKFDIITFTPARASHRGRPAFLNYDDLYVLHAAKRFGGVIVSNDRYADILKRQQYQQYHHIITHQRLDIQFIPVGKSIVKFGKDIFYKCLPNIEFSTTSQDTPVTMNQRSLFCMPFDADYEKVAFRGRHWSKSRRLEIIRAIDTLLHNLESKCCIYDYTSHVATLSPLLNVQFANCFPTYDKTRRKGPINTLHINETLSNYSNLESNTEENYTLTPRELQIIAFKESFERFSEQLKKKNSNSKLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBA2</accession>
    <name>A0A0N5BBA2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ell-associated factor Eaf</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBA2"/>
    <dbReference type="STRING" id="174720.A0A0N5BBA2"/>
    <dbReference type="WBParaSite" id="SPAL_0000331200.1">
        <property type="protein sequence ID" value="SPAL_0000331200.1"/>
        <property type="gene ID" value="SPAL_0000331200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="11">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000331200.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41616" checksum="C9BF41609294DB31" modified="2015-12-09" version="1">MTNNSNCGLPIGVYQINIGESLLSKDNNKTFHSIKYDFRPASISAGGAETFLQFSQNNYANVAIENESNNSLILYKGSDNKISNNKECMMLLDPNTNKLTIEKLSSQIRVKYLRNPADQIVQIIREKIQNKKGMKKEKTSEICRSEEREKSTPIRNPSTFVKLKEVKTSKMEDETTTEELLQGLDIDSPKNVNEDVVKNEEKPSMKGAVNISDFEDSSDGEFDDFLDKAVKTKENTTQDVVSGTEKSSNSNNTSNTKVNSEKPNDDLLDFFDNIDDFSNKSFPKSPKKPSPEIVKKVVPKETKPDPFNQNIFGSLDDSSDEDPIIEKNDKPKTVENKNNGQNKKMVGPGGRMWHDDLDLSEDEDEDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBF8</accession>
    <name>A0A0N5BBF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BBF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000336700.1">
        <property type="protein sequence ID" value="SPAL_0000336700.1"/>
        <property type="gene ID" value="SPAL_0000336700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF24">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000336700.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47351" checksum="819817FD981924FF" modified="2015-12-09" version="1">MASERLENLSINVDSEWYCKEKVSNISSISNEIQNIIYLYTLPITGTFGILAAIICVIVFTRPQMKCSLNVYLAGLSFFDLILLSTSIIIYPLLAGCTSQGSIEVCRIFAKLTLIFYPISLMAQVASVYTCVAITVDRFLAVKYPLKMRMWCSASKATFIVICIGVGSILFRIPSYFENTLGECGLYVQTKFAKNKYYYAFYHLYGQLFYLFIIPWAVMIVLNVTVVYEVHTAYKIRQQLGTRQACVDDGERRCTIMAAAVLLTFMVFNLPTVLNSFIDVYFGVSRKVTYFDRARVPVANMLICFNSASNLIIYSIFGRKFRRVFVKLIIPCFKRSEYKFLTQVVQQSDGNEMTKKYSQQANKNNSISNAERQTSRRLVYCRDKKSVCSQESMRFSETAYQKISGCHTAPSLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCM1</accession>
    <name>A0A0N5BCM1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCM1"/>
    <dbReference type="WBParaSite" id="SPAL_0000376650.1">
        <property type="protein sequence ID" value="SPAL_0000376650.1"/>
        <property type="gene ID" value="SPAL_0000376650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000376650.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8789" checksum="7C08D2067C21463E" modified="2015-12-09" version="1">MLRVLVILEFKFVQQKFEISTVVESSLKRNSWSEIRFSVLQSVIERTRQPSEDGQSLLRQCIVRPCGAPIKVIVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD52</accession>
    <name>A0A0N5BD52_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD52"/>
    <dbReference type="STRING" id="174720.A0A0N5BD52"/>
    <dbReference type="WBParaSite" id="SPAL_0000394200.1">
        <property type="protein sequence ID" value="SPAL_0000394200.1"/>
        <property type="gene ID" value="SPAL_0000394200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000394200.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20881" checksum="FCDF40682932290E" modified="2015-12-09" version="1">TYLDWLSDSGYDSFCILCNQSFTERDTIRLKCLHLFHKDCLHAREANMANDTKVESRRCPKCNDKIFPAQNQTSPTVEVLKVWLATTNWGRQGLGLPIDSSINDKAIPPPPTFNEKAIHEGPQERTQTPTVINMDGRVDSPQMGYNNKPHERSYSSRHGASSIPSFNYEPFTSQTTHLLNDENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE20</accession>
    <name>A0A0N5BE20_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE20"/>
    <dbReference type="WBParaSite" id="SPAL_0000424700.1">
        <property type="protein sequence ID" value="SPAL_0000424700.1"/>
        <property type="gene ID" value="SPAL_0000424700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000424700.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="33272" checksum="A8320D7B1F4D1328" modified="2015-12-09" version="1">MVEIILVIDIVQLIYKIPSTLLMIMSIYVTIKEIRNKNVYFNTQFYIIIVCKLTNEIAFIVTVFIFLKLPKWGFYNNFLRNNNWTATTFYILATQQTTFMFFITLLISINRYIAVKYPLSYKIYFSKSKIVITLLSFIILSTMIELGNIYFDANYKKSYLFVYFVPIFKSKDEIYYQIFYKLFLFGIISIATCIFNLMAILTLKRLNHIGRRFKRDLYYTVYSIFIFLTLIFVEAFFICGFIAVKYEIKSFVYLSYFLHIVAFDLTSVGDFYFLIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEG6</accession>
    <name>A0A0N5BEG6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BEG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000439100.1">
        <property type="protein sequence ID" value="SPAL_0000439100.1"/>
        <property type="gene ID" value="SPAL_0000439100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="10">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000439100.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24892" checksum="EC230421184C8EBE" modified="2015-12-09" version="1">MAIYTQHVTASKLMKRTLDGSDKDEEPHAKKDFKKDKDLEEQRKAGQIPAMVDVVSGRDINPHIPAFISQTPWYISTDGPTLQVFDATPHPDRQKTDIEINEWYNRGTTGVRAKKYRKGACENCGAMTHKKKDCFERPRKVGAKYTNEKIAEDEYIQPDVSYMSFDAKRDRWNGFDPAMQSEVIEEFEELEKTEELIKKEKIENGEVDPNADEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFR6</accession>
    <name>A0A0N5BFR6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Skp1-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFR6"/>
    <dbReference type="STRING" id="174720.A0A0N5BFR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000483100.1">
        <property type="protein sequence ID" value="SPAL_0000483100.1"/>
        <property type="gene ID" value="SPAL_0000483100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000018">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000483100.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19214" checksum="E1B2FE6A96212DB1" modified="2015-12-09" version="1">MVVKVPVRSSDGETFELEYDVIKQSGTLHTMLTDLGVDFSSDEELTIDPIELQNLNGNIIKRIIQWCNFHKEDPPSHDDGDQHEKRTDDIPSWDIEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKSPDEIRRTFNIRNDFTAEEEEQIKKENAWCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGD8</accession>
    <name>A0A0N5BGD8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGD8"/>
    <dbReference type="STRING" id="174720.A0A0N5BGD8"/>
    <dbReference type="WBParaSite" id="SPAL_0000504500.1">
        <property type="protein sequence ID" value="SPAL_0000504500.1"/>
        <property type="gene ID" value="SPAL_0000504500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="223"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000504500.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58563" checksum="1B99FE704D9DCA71" modified="2015-12-09" version="1">MERNISSDKDTLVQYAKDFALLNGLAMRTSEHPNSSDVIEHAPFTLFPSYFDEDSFYFAKNLQKDIQMLYYKVSQDIPFLIDTHKDIVNQDKLIKGLCDTLTKVSLDPSPQQFDLVLQRSDYMPHVNKNGKIEIKQVEVNNIAVSMGGLGEVVSNLHRNILDIFYKNVILNQQDVFLPPKTNPATLCAEGLVTALKYYHVIDYNSDPNKGMLLYGNLLPVNSACILTVTEDESRNIFDQRHIEAEVQRLTNYNVKNFRIPLSQLNSRLSLDDNKKLILDNKYEIGLVYYRTGYSENQYNDTTKDWDTRLLIEKSAAIKCPSVGLQLANTKKMQQVLANRNILEKYIDDNDTIDRILKSFAGLWGLGEGSDEEKKIIDDTIRNPDKYVLKPQTEGGGGNYFGEDITRLLKSLSNDELKCYILMEKLNPVLTKNILVRPNQEAKINKVVSELGIYGWLIVDKNNIFPNKNCTYYSYMMRTKESTTNEGGICIGAACLDSIIFKDFEKDFYRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGK9</accession>
    <name>A0A0N5BGK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGK9"/>
    <dbReference type="WBParaSite" id="SPAL_0000511200.1">
        <property type="protein sequence ID" value="SPAL_0000511200.1"/>
        <property type="gene ID" value="SPAL_0000511200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894571" evidence="2">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000511200.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27904" checksum="425154B444BCF7D9" modified="2015-12-09" version="1">MISSTYKTFFAILLVAFLSITLYSKPAPEERLVRERDSLIEDDNALLNLQFGMDKKLLENEEENLEEFKIREPRGSKKHKKDSSESSDDDSSEESKEKKKHECEDEPLSESSDDNEKEEEDCSEKDFKCHRRHHRKHHKKHHRKHHRKHHGKHHKCTTTKAPSTTTPSTASDTPRSSSPSTTPAPTTTSSPSEVSTTPRSSSPSTTPAPTTTSSPSEVSTTPKSSSPTTTSNSSTPSSTTASLTSTLKPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGW7</accession>
    <name>A0A0N5BGW7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGW7"/>
    <dbReference type="WBParaSite" id="SPAL_0000521700.1">
        <property type="protein sequence ID" value="SPAL_0000521700.1"/>
        <property type="gene ID" value="SPAL_0000521700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894257" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000521700.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9416" checksum="F07BD95BE7DA2BC9" modified="2015-12-09" version="1">MKNIIKMHFIKYFTILVLLAVQYSFQDDTTTYATTPDCTNNCATRDSDFGTTQETPSYPDTREKRALLKKLVSSNKVFLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIN1</accession>
    <name>A0A0N5BIN1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BIN1"/>
    <dbReference type="WBParaSite" id="SPAL_0000581100.1">
        <property type="protein sequence ID" value="SPAL_0000581100.1"/>
        <property type="gene ID" value="SPAL_0000581100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="623"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000581100.1"/>
        </source>
    </evidence>
    <sequence length="1312" mass="150699" checksum="0B8F94E57846A673" modified="2015-12-09" version="1">MTDNKPGGGDLSLDEGATSHANFNDDDVVWAIKRDDLELFTLDYLKSIKVMEMIINKFAVDSDTEEVKEIMNEILTHISKVNEKKVDKDNDSDLIEAKRRISELEKEIEKLKISSDKESGTITTHQLIEIISLTQKNMMEAFKSLKSEQTVSGFSNIDPSNFEIFKNEEEDITHHVLGVKRRMKLRSITVDEDKFLFMMVTLSNQIAGFIEENLPYPRSYSVLRRFLLEKYDGRAAKKKLMNDINYFKLDFSKRDIGCQLKPFVQKIAIAYKELNATELLVTQRRLIMNLFSDKNTKLYFYLTTTKPDDIFEYIRQIQNIFELDNIGKTFVSRSAPRPNLAEIVCRICNKKGHIARNCLEGASNKLSSPIPSKNAKRVRDVTYEQIVSSYVNNSDDDDVTDQNVFVYMVKQTDQSNITDDIYQHIVLQINDKLSKAFIDSGSCISFVSEKLLDASEIFDVKPLIARTANNSRMSLSRMSNIYINFLNGYDIKVKAFVVGPEILVNEDILIGEDVMSRCGLSISYEGGKCVKIKDQKCVSFKTDSKESRIVKKVKICNDVVDLKNKLFSDYTSLIPKSRYDVGEGILVCDDVEVVNKNFDFKPPSYGIPYSYKERVYNDFIEMEKAGIVEQRPAKFIHPLVVIPKEGGKLRLCGDMRYINYFIKPKFLPANKPYELVHNLCGYKHYSKIDLQNAFYQVRYPETTVPLMGVKVFDKVYCFKRMVQGAKVSAVEFQRLATQIISNLGEGYFAYIDDFAIASSTTTEDHVLKVRKLLDVLHLYDMKVNVEKSSICGDQITFIGYDISEKGATISKRNIDAFIERDVPSNKRQLMSFVMAASYFRGNMPQFTRNTLFLQNMVNSLKYKTSKIIVTDEYLTAIKTLRNMMMNPMYLVKPEPHDVLYLESDASQEAVGGVIYKISSSKEKQAIMYYSKKMSICKKNRCITYLELYSIHLGVTKYREILVGHKLIILTDQKPLEGIVHTKETKFLELILPLQEYDFQIKYISGDSNGCADFFSRTNKVSLDKGSIENKEYFQDSCNSTKLAEKLFRKYHLEMGHVNLSKVKDDLVKFCYEEKLSKFKACESIKKVVEMIKQCELRTVSLVFCGHTNVKMLDDDALITSLNFIHTQLQLKTKEIRCDKGLAFGSKKFQQYLEKHGIKLNFAVSYEHYANSKVERSIRTLRGLLTKLESNIDHKGPKGFQNKLTEACYVHNTTIHSGIGVKPFNLIYAYDVGDGKMTSNLSDLKLQARLYQQFMTAPEKRVIYRKIKDGKPVNEVGVYKERIDNVTDVKLMPVDSKDKRKFVSISGYKNRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ10</accession>
    <name>A0A0N5BJ10_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ10"/>
    <dbReference type="WBParaSite" id="SPAL_0000593800.1">
        <property type="protein sequence ID" value="SPAL_0000593800.1"/>
        <property type="gene ID" value="SPAL_0000593800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024">
        <property type="entry name" value="BIOFILM ABSENT ON HEAD (AFTER YERSINIA EXPOSURE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894662" description="Glycosyltransferase family 92 protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000593800.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="55519" checksum="7DCD728DC4C69A18" modified="2015-12-09" version="1">MMIKILLALLFLYQILIVNALNCQLKNTRFITNNTANYDSLHIYSFHVVPKNYYASKYATVKGFMVAYCDNKYTRNPRKEYLIADIDGKKFNGIVKIMQYSFCALKYINCRLEIFYVDFNIPRNLLVNRENITIIDNGSKKKRVFKLSSEAANSEVYDGITICTPTLYWYNNWIQMFTFLEYWRKQSNVHIVIHYRGMSSNVFKLINYYKDLGLVTLIPTPALPKQKGKNIEPFIFGFGGKVYLNSCMYSKNTKYVLAMDSDEYIHFFKNKTQHVYDFVEKEVKLRPYLKSVNFKNVRASYTHRKITETFRFAQRYYYYKDTINKEGKSVVRTSKVDMIGYHMPVGTSTKQLYRVNNKVALVLHARPNYVTVNVKGKRKIPKALLFDENERLVIAKHYNEIKEKIMNGTLKFNYDVKLANSLKITDRYKPKKYICYFDYEESKKYVSKLENWIYGEEQCNMERIFVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK71</accession>
    <name>A0A0N5BK71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK71"/>
    <dbReference type="STRING" id="174720.A0A0N5BK71"/>
    <dbReference type="WBParaSite" id="SPAL_0000633500.1">
        <property type="protein sequence ID" value="SPAL_0000633500.1"/>
        <property type="gene ID" value="SPAL_0000633500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000633500.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="75089" checksum="5D3CF0F885AB08E6" modified="2015-12-09" version="1">MDGKKEKFVCPHCSEVMDVDMIYLHVRRIFNSALYKCRECDFSTNDTFHRHHHKTTTGHRLEDKTELDPLLEKVINSTATIFMNSLVGKSESTNVVKNVNKPKEIKKIDNLKPPTNGNETPTTVKRPPSDFEQKRKFFQNTIYSISTMSFEYENENNSSKGKLGNLNNHIFLAVEVVEISTDAKLPKQKYNVPLPLFGKNKMVACQKCGKEVHESYLSRRKHVFKEHQDDIMQKLKDIKSFKKTDILFNGFMIIRDCFPDHVVCSDFQCVDCGCYYCSISGVRYHVGVSHQKSIVINCPFENCEFKSGSSCHAKDHIRIHMKGIADGKHDVSIKDLASYVSPQSFAKFNNSCKNESHLTKCISKHYFPISMTYYENFQKDFKDALSEFKRSYLQIHVLNDLISTNQGMNESEIIPPHNDTIEELDDDSDVPEECMVEQNNISGKKRKRDDSNSDGEGSDVIFLKEIPLKSKKNSISEESTSSGASVVIENSPRYPSNEAVNTKNNEVSLERPNVPRPVNKQNNEEAMESGKIEKFKKEIPPLEAVTRNFIQNNGNGKLKEEIAPRPSISLDAKKVKDEFTTLPPESRAERPYKDSAYETSSRRGEEIRTKPRQGDFNKERYHNKSYSNYNDNRRHSSMSHNYDNSFKYSKSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKR6</accession>
    <name>A0A0N5BKR6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKR6"/>
    <dbReference type="STRING" id="174720.A0A0N5BKR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000652100.1">
        <property type="protein sequence ID" value="SPAL_0000652100.1"/>
        <property type="gene ID" value="SPAL_0000652100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF12">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894525" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="63"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000652100.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="42549" checksum="23F1ABCFC701070B" modified="2015-12-09" version="1">MLKLYDLIFICISLLYLVNSVGTVFTNINDETLESEEHDKFQKSYNNSVFEGISQKLKRDIRIFCVILTSPKFKFSKCIPQKMTWLKRCNGYVFASSRNDPTLPSIKSFPKDKYKFSYGKVKNALRWVYKHRKNEYDYVLKADDDAYLVMENLRAFLINENPDDHSYFGFAFRNPPKYHVMGFIQGGSGYVLSRKSFNTLVEKGLSNKKYCSQKKGLSNKKYCSQRNDVPDDVEIGRCLFRMGVNTTFLVDDRNRNSFYPEPITRILAKDKRIMNYYKEKSFIQPERGMEILADFPIAFHRINSDLMYFLEYLFYNAEVIGKKSRLFRMEDNDEDDENEKIKKRMELIKTFSQYNYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKW3</accession>
    <name>A0A0N5BKW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKW3"/>
    <dbReference type="STRING" id="174720.A0A0N5BKW3"/>
    <dbReference type="WBParaSite" id="SPAL_0000656600.1">
        <property type="protein sequence ID" value="SPAL_0000656600.1"/>
        <property type="gene ID" value="SPAL_0000656600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000058">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF45">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000656600.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31967" checksum="58F8AFE64CC37F0C" modified="2015-12-09" version="1">MNHQYSNDRNCKSKSQFDNSKSSNYIKNGTILKIRYGTGSASGYQGSDIVCLTPKALCIPNQDFGQATQLAQFFSDTPIDGILGLAFESIAVNKITPPIINAYNLGLLEKPIFTVYMGHFGLKDEQKGGTFTYGGLDTDNCGDVIAYEMLTSPTYWQFNIKGVSFDLFSDTTTSTAISDTGTSLISGPKGIVDIISDKVGATFDVSLQTWVVDCNYKGPPITFKIGDNSYEIPVINYVLPIDGDICEFGLFSLEGMTFGPTWILGDPFIRSYCQIHNFVDKSIGFAKPKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL08</accession>
    <name>A0A0N5BL08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related C3 botulinum toxin substrate 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL08"/>
    <dbReference type="STRING" id="174720.A0A0N5BL08"/>
    <dbReference type="WBParaSite" id="SPAL_0000661100.1">
        <property type="protein sequence ID" value="SPAL_0000661100.1"/>
        <property type="gene ID" value="SPAL_0000661100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033563">
        <property type="term" value="P:dorsal/ventral axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000661100.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21421" checksum="EE6E512A4B7B870A" modified="2015-12-09" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDAFLLCFSLVNPASFENVRAKWYPEVSHHCPDTPIILVGTKLDLRDDRDTIEKLRERRLAPISQQQGLKMAQEIKAVRYLECSALTQVGLKAVFDEAIMAVLRPPKKKKKRSCDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLN2</accession>
    <name>A0A0N5BLN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLN2"/>
    <dbReference type="STRING" id="174720.A0A0N5BLN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000682800.1">
        <property type="protein sequence ID" value="SPAL_0000682800.1"/>
        <property type="gene ID" value="SPAL_0000682800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000682800.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12063" checksum="C4722C360B4DCA27" modified="2016-05-11" version="2">MKDKIVSKFESINELDFTISSDIWTKENLFKATKLFQERGSEEDTVEILEKLIKINVSNVPSEIGIELQDFIYEIVKRVSISSFAEKYQMTMILFINQCPYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLS7</accession>
    <name>A0A0N5BLS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000687300.1">
        <property type="protein sequence ID" value="SPAL_0000687300.1"/>
        <property type="gene ID" value="SPAL_0000687300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000687300.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13144" checksum="84C0D0051FAA7C4E" modified="2015-12-09" version="1">MLNSTKSRINVSKTIGKRLLFDRSIEKEDEPAKKNFKLDLSWDYDAFVLPDEEDLSEQDKSLSTSILEISRNLVEETKKYEERNSDGSDDNSEESSLYDPLEDSFDYLNDSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLT8</accession>
    <name>A0A0N5BLT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLT8"/>
    <dbReference type="WBParaSite" id="SPAL_0000688400.1">
        <property type="protein sequence ID" value="SPAL_0000688400.1"/>
        <property type="gene ID" value="SPAL_0000688400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894707" evidence="3">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000688400.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31419" checksum="CB6C20D61F3855A9" modified="2015-12-09" version="1">MKYYVNFIFVILSGFIIGTKHQESTCDFTSLVKCFIEVLDEWTWTLYELSDIKKNMVGITNDQCQHLRKLEICMDDGNENPHSCTHKEVVEVSNTVSDLITHRKNAGSFLKSYYLLSFACSNEGQKLINENEECFRSEHISEMTISAGTYLSEKFLDGDKEDDDICSDLNEKMEEYKEALRQACNKRAQYLMCKSLESMFKGLHADKLEGCDLNCGSIDDLDEEPEQEHREEQSEPEIGQSNALLNAASYSQIGGSLSTLPVIIVFLLSAIYLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM12</accession>
    <name>A0A0N5BM12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM12"/>
    <dbReference type="STRING" id="174720.A0A0N5BM12"/>
    <dbReference type="WBParaSite" id="SPAL_0000695800.1">
        <property type="protein sequence ID" value="SPAL_0000695800.1"/>
        <property type="gene ID" value="SPAL_0000695800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036465">
        <property type="term" value="P:synaptic vesicle recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047161">
        <property type="entry name" value="GIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097:SF3">
        <property type="entry name" value="ARF GTPASE-ACTIVATING PROTEIN GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000695800.1"/>
        </source>
    </evidence>
    <sequence length="714" mass="81915" checksum="BB52BF2AA09BE60C" modified="2015-12-09" version="1">MAIFNNHTIFSSWRCADCDAEKPTWASINLAVLLCSDCASIHRDLGRHISQLASLQKSYWSPYRLDLLLYLYANGSNNVWEYFLTDPSRNDHNNQKHFIKPKPESAITPTKERFIKEKYVDKKYASRGVDENQNDLDMQLFACVRTCHVETAFRLLIHGANPNYVNYETGETPLHIAVKEGQLKQVELLCIYGANLHFINNKEESAKSICQASGSTDLLTRILEIEFEISDRISWFLCGKMPSHDKNSHFLIPDIVGSQLTDKQRMVIKKYVNQNNELFCSISQDIFDEIERRTNEKIWYGETKERHEKLGSVVNVISSFLPLNPLIPSFRNQRRQKLAKFDTNAFVYLLVCHLKETKRRFYCEDIETSIGRSIKQQLRRSQKSSEKNYSNNDYEDYASVPSPESLSRLSERKFVKRQSPLQNRFGCDTTSNRDVEILQNVVKKQTETINNLSDVIISFSREMKVMQEKIDRVAEENATLQNDLSRLRAHVYMKDTQFASQTNAFNTKNTPSFSPTNGPSSNTSNISNTPPIFNTTYSVQRTIIAPQNSSNTFKGHISPDNDYMHNLEVNEKYVSSQNVQSQMDNSYVNVLSEKRISTRNEKNRPLKDGLSKTKIVRFVDDLTSAIRSLQTELLKPSPFVYPHCEAVNVVVFNILNSVPKSLQRKTVIVLMQKLENSMYKLESICSNPNINVHEASLAAFALALAAKNLFLTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH5</accession>
    <name>A0A0N5BMH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH5"/>
    <dbReference type="WBParaSite" id="SPAL_0000711500.1">
        <property type="protein sequence ID" value="SPAL_0000711500.1"/>
        <property type="gene ID" value="SPAL_0000711500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711500.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42068" checksum="5CF972901BEC253B" modified="2015-12-09" version="1">MIKDINPDDENLLDDNNNDVAKSTDIVGTKPDDPSKGNKDKHSNLPDPPLIKLINTYIKIIFYFTDPPLGEDKSKKRKSNSSVEEYAKKLETDNRTLESYFFLQLINQMPSKPMSFCSIMAFDSFKVYHKLMNAININLLESSMQKNVSLPLEVNKNVDFGIINKGNSLLRIYSLSAGNRYRGVKILVPAGAEFPSMRIPDWKELLIIYRGGTVSGNLPPKLEFLGLEGFKESINVNWKELFMGVTKLKVLLTVSCEVFKKLEKLIANMKTLQAVMCMNKQGCKCYSSPLRKTFIRELSIVPDHENNNTYFADVGRAKKARKPNPRFHYSAKIYYRNENILTKICSTELPSTIKEELKALSSKNPKTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMN2</accession>
    <name>A0A0N5BMN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMN2"/>
    <dbReference type="STRING" id="174720.A0A0N5BMN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000717100.1">
        <property type="protein sequence ID" value="SPAL_0000717100.1"/>
        <property type="gene ID" value="SPAL_0000717100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="557"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000717100.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="78091" checksum="3B9BA650486C40A2" modified="2015-12-09" version="1">MEEEFWRKNSFKEEVFSSGKKNYPDICLCKYDLKNSNYNNNKKRLFVVRLLQRFISFFPIISWLPNYNVKENLISDMVSGLTTGIIHVPQGIAYAKLSGVPPVYGLYVSFLAPFFYLFFGTSRHASIGSVSFIALMTGVTNEMVQEKYKIGIFEPLNNGTFIYREGEEWKGSVTPIQITTTLTFTIGIILLLSSILKLKVLTTYMPDSLIKGFTTGAAVHVLLSQLDDILGVNIPRISGFGNVILKLIALTQQIPNVNFITLLCSIFTIAFLWIGDIFITPFVKRKVSPKLVIPFEMIIMAFFIVMSNFFYFNQNFNVNIVGEVSNTLPKPEVPNLKIIPDIIINGIMISIVIMTVHLSMTKMLSTNMNYEKDLKSGQELYAISFTSILSSFFPVYPNALAIGRTMVLVSSGGRTQLTNFFSASLLLFVILFIGPFLYHLPMCILSSIIAFALRSIFRNLLLIRNIWISSRYDGMIWITSFLATVFTDIVYGLVISIVFALFTIVLRTQKPKWFLLFPVSPNFMAPLTKKKSKSIGDKVNSLEDWDCDSLCYPLFAVHRFEGPLVFTNGDIYRDSCYNSMEELKERLKIKSSTVSRNTTLVSSTIVLILDFSRITQIDLAGIKVLNEIITHAEVLNIQLIITSLNHSISKSFKKASILKRKLPIYDNVQKAINSVINFDYNLQNITQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMR3</accession>
    <name>A0A0N5BMR3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMR3"/>
    <dbReference type="STRING" id="174720.A0A0N5BMR3"/>
    <dbReference type="WBParaSite" id="SPAL_0000720000.1">
        <property type="protein sequence ID" value="SPAL_0000720000.1"/>
        <property type="gene ID" value="SPAL_0000720000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF7">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000720000.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11191" checksum="943021E27C574BAA" modified="2015-12-09" version="1">MASLTAEPAAAEIPAAGGKSVHKLANPGANRVAFKIKSSNNNELRLKPVFGFVDPGASADVEITRLAGAPKEDKIVVHFAEVPPECAKPEDAFAGGATGTGNLTIPVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMT9</accession>
    <name>A0A0N5BMT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000722250.1">
        <property type="protein sequence ID" value="SPAL_0000722250.1"/>
        <property type="gene ID" value="SPAL_0000722250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000722250.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14433" checksum="8ADBEF38A50C0A85" modified="2015-12-09" version="1">MDLDTILVFYFRYNSDSKLYFGQRVSVLPLYEYECLKSVVNHTSKGYSFDMYIQLEVPDIKTTLRLKINGVVKNIIIGNNSEIMYIYTVFASGMDDGQVECLSVSNDMKVLAFEDFYKKRCRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN24</accession>
    <name>A0A0N5BN24_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN24"/>
    <dbReference type="WBParaSite" id="SPAL_0000730400.1">
        <property type="protein sequence ID" value="SPAL_0000730400.1"/>
        <property type="gene ID" value="SPAL_0000730400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF875">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000730400.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44000" checksum="5A9EAFCDE98CD6FF" modified="2015-12-09" version="1">MGVQIERLFFINNIFKNEGTLKADGNSESYETRIKRSIINNMEFKWTSPIPYFCRFNVNKTLVQEALAILEKETCLKFNETVDFTNGFLRYANGTNRCYSQLGKVSNNDLHDVVVGRDCSYVTGILHETLHALGVIHEMSRHDRDSYIDVKYENIKPSSQFNFVRYELTRASSHGLKYDFGSVMHYNRYITTKNNQETMVPKGKYKSYLKTIGQMTRFGFNDAKQINLKYCSDKCRGSKLKCKMGGYPHPNDCRFCKCPAFFTGILCLKLLPSHKQCGTTIFKTKIVDKQLTANGIKTCYFQITAPIGRKVRLNIEKTDLLESYVCQPDQGLEIKFLADKSVSGSVLCGKNSGEIIISENHVVVMKYVGLTSNSTIKIRYRDVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNS4</accession>
    <name>A0A0N5BNS4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNS4"/>
    <dbReference type="STRING" id="174720.A0A0N5BNS4"/>
    <dbReference type="WBParaSite" id="SPAL_0000755200.1">
        <property type="protein sequence ID" value="SPAL_0000755200.1"/>
        <property type="gene ID" value="SPAL_0000755200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF4">
        <property type="entry name" value="CHITIN BINDING DOMAIN (CHTBD2) CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894608" evidence="1">
        <location>
            <begin position="28"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000755200.1"/>
        </source>
    </evidence>
    <sequence length="928" mass="98712" checksum="2566EDC896FB8EA9" modified="2015-12-09" version="1">MAAIINYAILKKSLCIIILFLFYSIDGENNLELIDGRMCMTVEHSRSTSNSSTYYECVPLSESDNEQYRIKGKYLGIWTLRKCQKNFEFDEAQQKCIEKRKLHRQPATGENNECQASNVNPIEGGECNWLTATLQNDPYSRNHFLQCSITIPGEYCGEWVRMPCAPGTVFEFAQQICVAEEIDNNNECGKSGGSPVCPCSGSSGTCPGISICISSICCQQQQSDPSMQMLQQAPFMQQPLCIGTGARPIGPCQLNSCPSNYECQDGIGCCPTIPSDSLSNIVSVSVKVCPGSSIVPIGTCTNGNTCPSGTFCNEKVNGCCPQLEDKKFTVIMLCPNGKPAVGTCNANNLCPQGQNCFKGACCQLSTCPLGQQPQGFCNSGACSNGGTCYQSTCCQSVEIIKLPICSNGQASTVPCTMSNQCGAGFECSNGGCCPIPFCPNGIQALSRCNGPCGAGTTCLEGLCCPLPKCPSGELANTMCTQNRDCGIGSDCTNNGCCPLPQCPSGNFASCRCGAGSGGKSCPLGQTCINGGCCMLPLCPNGIQAVSLCTASFQCGIGMECVNSGCCALPTCSNGKAASERCQMGGCPPNKICENGVCCDIPVCSTTGMIPAHFCGMGNSCPQNFYCERQGCCPEPLPLCPNGGRSTSRCDRGSDCPLGFGCTSLGGCCRLSLEPICPLRMNAICQCSANNGCPQGSTCNQGTCCTQASATFNQVPGTSCQMSTQCNGFTNSNSRCLQNTCICTKGSISNGASCIQQPAIVVTQARNGCDQYGNPCKFVLSSTRRRPLFTPVGNVTDTPLWFNVIELRSCIDDPSRTGIDFDPDATCLPNEKCINGKCRTKLWPGEYGCNSDLECQARCPNTYCETKTDKNVPQCLCTHGFLLYGRCVENCPKGFHSSGKYCMHNDEDHFWKDASQQDNLRELLNKGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP50</accession>
    <name>A0A0N5BP50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP50"/>
    <dbReference type="STRING" id="174720.A0A0N5BP50"/>
    <dbReference type="WBParaSite" id="SPAL_0000767800.1">
        <property type="protein sequence ID" value="SPAL_0000767800.1"/>
        <property type="gene ID" value="SPAL_0000767800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002010">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000767800.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14765" checksum="F8B238E0C5716A6B" modified="2015-12-09" version="1">MLVENHLTNLIDIPPQQSQNLSSTISVTSNSINSQSSPASSNSATPASTLPPIIICPSEIDTISITLEKNQQCACKDCGKLFNSVWYLKQHAVKHSNDRPFKCKFCMKTYKFRSNLYQHKCPERVKSMGNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ73</accession>
    <name>A0A0N5BQ73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ73"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ73"/>
    <dbReference type="WBParaSite" id="SPAL_0000804100.2">
        <property type="protein sequence ID" value="SPAL_0000804100.2"/>
        <property type="gene ID" value="SPAL_0000804100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000804100.2"/>
        </source>
    </evidence>
    <sequence length="709" mass="85008" checksum="CB5DDD999E98B9E6" modified="2015-12-09" version="1">MIYFYYQYHLIFDEITIEYDLSTNNVSFLSEVENKSIPVLWKHPLVSHINCGALLNGDSSYIMKESKELKKLKYLPNTFSTLCEDIKKRGHYPDKPLSQEEADFPIAYIRTIYTDYLTLEYQFLLTYAPQNYYCFIIDKKQPAHFHNKIYAMANCFKNVHIIQNRYQMNSRGFNVNSANYDCMRYLNDKNYKYVVVLNNDDMPLKTNRELVEIFKIYNGSIDIEYADPRPFYDRVDFNLNWSLGHLEIFKEGDPRKLDNKILSSQLEFQKGYNAIFYPKETVKYFVEELNLTKFFKQLDDMNLYANDEFGFQSLIANEYLNIPGRIDADCLKKDYFFKDSYMTRYVKWIFDGDCDESETRHYDYLTLEYQFLLTYAPQNYYCFIIDKKQPAHFHNKIYAMANCFKNVHIIQNRYQMNSRGFNVNSANYDCMRYLNDKNYKYVVVLNVSFLNIILFFQLLQNDDMPLKTNRELVEIFKIYNGSIDIEYADPRPFYDRVDFNLNWSLGHLEIFKEGDPRKLDNKILSSQLEFQKGYVTISYPKKTVKYLVEELNLTKFFKQLDDMKLYANDEIGFQSLIANEYLNIPGRIDSDCLKKDYFFKDSYMTRYVKWFDSGYCDRNETRHYICLHNIKTLHSIKKVPHLSVNKFKGEFDFGGLTCWVEYMYNRTYFEHYKPINKSFYENLSLVKYGNLKNHIKDKEQLCEMSRSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQE2</accession>
    <name>A0A0N5BQE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQE2"/>
    <dbReference type="WBParaSite" id="SPAL_0000810700.1">
        <property type="protein sequence ID" value="SPAL_0000810700.1"/>
        <property type="gene ID" value="SPAL_0000810700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894867" evidence="3">
        <location>
            <begin position="25"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000810700.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43286" checksum="A3A73A67E96796C6" modified="2015-12-09" version="1">MRLFHILKLSIVLQILTLLGSISGANENSYVTVFESVESLTRKGSYYYQYIKNEESNKEFDLKCLPSKDSGVGPLARSKYNISHIPASGGLKENIFKVRFSSDSMENGFGKYKCIKLDDKTEGELVFYLPSPSYKLNFKKVNISSEIKPDCTRSYMFANLIKVTANIKVIEGNLTNSGDHSFTNFGLSNGIFSSNDNRVFFDKRIYDTADVTIKCIYELIFGKDNATFETSQIFTYTKANDTSSSHTIQKKFQETVTNVEKTSPIPIIIAFVVIVIALIVTAIVIAVIVRVKKRRRRRRQLEESALSAAQSGSSSQYSSSSTAGSSSYTSKSNQKKGSKTGSKTGSKTGSMTESRSGSKSGSKSGADPNARQPVRTFQSFDGSLSGTSPNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQE3</accession>
    <name>A0A0N5BQE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQE3"/>
    <dbReference type="WBParaSite" id="SPAL_0000810800.1">
        <property type="protein sequence ID" value="SPAL_0000810800.1"/>
        <property type="gene ID" value="SPAL_0000810800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000810800.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36312" checksum="A819D14CA3DAF74D" modified="2015-12-09" version="1">MDFISLPEDFKLQIFKKLHWKDSNNLKLVCKNFYLTVVSNIEKLDRPKIDCLKVCYGDNKILGADYDFKRTENLLTHGGLKHVEFSNDSEYENFLKDRDLTKIKELILLDIENGGVIMVYDSSFIIGIISRYDFTISLSNGTLFSTRLNVSISSTKKLGIPYTGKVLRKESLRKMGLFERGGSHLVIKKVIMDIITGDPMLEYQSASSDTTEPIFIHITNHLCDLGFLNIKNRCDGKQFKLCFFGSDKFDNLEKEFYRKLFDKIKFGNDLVVEDNHERYYILNFINCPRCGTQHKNFILYEKSFRAFHIHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQF5</accession>
    <name>A0A0N5BQF5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQF5"/>
    <dbReference type="WBParaSite" id="SPAL_0000812000.1">
        <property type="protein sequence ID" value="SPAL_0000812000.1"/>
        <property type="gene ID" value="SPAL_0000812000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608">
        <property type="entry name" value="PROTEIN CBG07207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608:SF3">
        <property type="entry name" value="TNP_DDE_DOM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000812000.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37447" checksum="96EBCEBBFF8118A9" modified="2015-12-09" version="1">MIHPINIPEELFASNPRRPKLLITNDKPRKKLSYTSDGRKMVDDVIKSPLSPNAIWKETFLRTFIRRLSVSKVVPLTKINDKHKQRSISPNDDAISRTSIPIETCDMIDIVDLEPKNTYKSQIDQNNVTTVILEDDEILKNCCPVDYNAICPILEDCCKSIIDSNGDRKYQEFLRCDFSNYNKSLLFNEELCASNHGRKNSIDFLPSPVGNRIWLENETPSCGCDTELRFNIQQIHKNDDVINIEVHVNNGNAMDVLFKTLLHVHIKDNNGNDKRAAVGENLHILRRHDDRNIKLWIPINDLIKEALNNEEKTLIFVVMAKLEMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQG3</accession>
    <name>A0A0N5BQG3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQG3"/>
    <dbReference type="STRING" id="174720.A0A0N5BQG3"/>
    <dbReference type="WBParaSite" id="SPAL_0000812800.1">
        <property type="protein sequence ID" value="SPAL_0000812800.1"/>
        <property type="gene ID" value="SPAL_0000812800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000011">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="78"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000812800.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="77472" checksum="7DB3F613829BBC2F" modified="2015-12-09" version="1">MGMERKRKTSTSSSTSSGTTSTPTSSSQQTSPVAYYYTSGSRKVNVHKPPYTEEWSRCFQHGKIQLKNLRQHALEGDLRSSKMRSIYWRLFLRILPLDKDEWYSIVERCRYEYQEIKCRHSRDSKEFNEGDPQSNNPLSEQENCPWSQFFYNSELKEQIKRDVDRSFPEIPLFKNPETREIMINVLFIYAKEHPHIEYKQGMHEILGPLLFVLNYDQENFITLKEANIISSLNENDKRLLGFLNDPHFREHDVYQMFTGMMLLIESWYIYGDENLSKSDDETNRSSSSVSNDNEYISNSIDNLKKLKKKRKISISTYQSNLFKQSVDDDNSKSLIIDKLKEIMECFLKEYDNVLYNHLKNLNILPQVYGIRWLRLLFGREFPFPDLLYIWDVILSDDDPLVMIDFIFLSLLLQIREQLLSGDYSCCLQYLMRYPPIIDVTNFVKFALHIRSPKKYSMPKMSGPMNFSNITLTGQLHPNADKKKYISIFNDQKDVKKNSRDKENDSLSVFSQASSNDNNWDEGGSHHHKNSIENIRNSPELEMMPMNRRHTFTNGSRTPMLSSTEIQEYESMKKQIDSLQQATINSETKQFEASQRLYEIISGIKQLNIEKDIKKQLAKSIGEVAAKLSYSSINEASIRNVTLPTDASPTREGVEVAIEAKSPDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQX1</accession>
    <name>A0A0N5BQX1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQX1"/>
    <dbReference type="WBParaSite" id="SPAL_0000828000.1">
        <property type="protein sequence ID" value="SPAL_0000828000.1"/>
        <property type="gene ID" value="SPAL_0000828000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF794">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000828000.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32292" checksum="62602A67B07B7E84" modified="2015-12-09" version="1">EHSRSDRDEFVQIHNFWIKSGAESEFAIQNSREHSNLSVTYDYSSIMHYGTTDGTWFEWFPTISAKKYKLFEFMMRQNKNMTFNDFKQINLHHCVKCNWVDMLYKKYEKKHEKARWGKCYFGGYPDYRHKTCKKCICPKGYTGDKCGHIVESDKKKCNGTFLWAFRQRRWYIVRGEQKCFVLFKSANNQKVKLMIAEAHARNLRPCTEDYAHQIKYLKDKGNTGLLICNNNYDTINVTSEGYTILLYYNGQRPNDYFIAAYQSVSSNLPTAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR73</accession>
    <name>A0A0N5BR73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR73"/>
    <dbReference type="STRING" id="174720.A0A0N5BR73"/>
    <dbReference type="WBParaSite" id="SPAL_0000837700.1">
        <property type="protein sequence ID" value="SPAL_0000837700.1"/>
        <property type="gene ID" value="SPAL_0000837700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="197"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000837700.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="53690" checksum="40FB623460074C70" modified="2015-12-09" version="1">LLAGTRKTQSICSALLTGITYGKRYLVVGPTNKACDAILERLFTWDPETNMVLSIKSKSAMVRYPDTHNRSELYYFRHGLERIKDKMEKIDRDKLQLYQSNKASYGSLKANVTDLNEDYFKNLNDAKSRLKNTETKLPSLIMKYINPKIFVCTIDLLIGGIPKAYTENGFDHKIVDEASQVRTSTAILLLSKFPTSNANYRSHPQLVALLSDLFYDGAQYPIRQHYDIDFSWIKLVKHNQHRLSPIYPYYLFHINYPSETHHSGSTYNPKEALDISIFLLYFFTIDYNPDDLATVSMYKAQVNQIHRSAMTLLNRYEYYLKSNNMSSHLIDHKKYTFEDYKTKLIVDTVDGFQGHEKKILIISTTRSTARPDDHETEFYRLRNRICVALTRPNLAFFLFGDISLMKKCDTWGSLAKRMEKEKTVIPFDKTTLANIFFRRGPLSNFINYYFNLRDLKEFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR76</accession>
    <name>A0A0N5BR76_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR76"/>
    <dbReference type="STRING" id="174720.A0A0N5BR76"/>
    <dbReference type="WBParaSite" id="SPAL_0000838000.1">
        <property type="protein sequence ID" value="SPAL_0000838000.1"/>
        <property type="gene ID" value="SPAL_0000838000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="350"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000838000.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="67259" checksum="4AE39699E6282BE1" modified="2015-12-09" version="1">MTPEAEDAFYKLRELIGNPKILNKADRNKPFYLTCDASSTGLGAMLSQYDNEGNEVPTKMISISKAVSHYRHILLGSELIIRSIHLPIKRLLRKNNDAKFAELMIPLQEMNYRFEYIKGKDNIIPDDLSKLDPEEILKDSSNLNKLQSDDEEKELISLQKMRFDELWKREKKLEDEKRKMVNCFKVLTEEIEEIDDSSDEEDVEPSNKEQALNKIDDDIPLLQKLYFGSEENFDKITMEEQLSDPFIKEAYEEKMYDKRKIIELNNQTMIEDLTGMGYVIMVPNSKIGTVLNIAHNLSGHYNAEKIFRRLKDVCFWKNMFMDIQLHVERCRECMLGNDIRSKNYNQKSVIFLRPMQSISIDVCGPMNVISHTGNRYVLGIIDNFSRFLIMTGLKDLTYTSIVNNLFKKLFFRHGIPEEIPNDNAKSLVNNKLTSLYQMLNTKQTTGAPYYKKANVLIERAFRKLHNICTKLITKETAQDWNELLLPMTYFHNTMMHGTLKCTPYEVFYGRSCRTPSHVMLGKQHNSLFDKDVDRWELTKNALKAYKHIEDTIVECRDKENKKNGGKDFPSFEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSL7</accession>
    <name>A0A0N5BSL7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4201 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000885900.1">
        <property type="protein sequence ID" value="SPAL_0000885900.1"/>
        <property type="gene ID" value="SPAL_0000885900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000885900.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44880" checksum="03097C9AEBF34B73" modified="2015-12-09" version="1">MEKYIGIEGEINFHISEKTKNLINENNKHLLQLEEKAFKIGETSKVRYFLPPFDFLKITNSEFNKLDLLNQSGNSYTELCNALIKDAEMINDSLLKSINSFDMILRDTDEQSAGNSHFTTILEKLTDVYKRLENVKSDLLEKSEEIKNKNEQISHLQGELERKNENYNKRMRCYIERKSENGKIKENERSLHHERTLHEMSVYNSMCKDIEKKIMDKIKENALLKENFKLNIKDKLRANYGMYFGNPKTFIKTKTKSKRQKLSDLLLGIKLLIKESLNEELEKVEKLSREVSHLKMREVKLLSNIKHITDENPMLENKIKRLTEMKTKFEEFLDDLIIKSCRIHSVDRKKFLTQFSFDTCYSGNTSFSAIFLSMLDESKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT85</accession>
    <name>A0A0N5BT85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT85"/>
    <dbReference type="STRING" id="174720.A0A0N5BT85"/>
    <dbReference type="WBParaSite" id="SPAL_0000907300.1">
        <property type="protein sequence ID" value="SPAL_0000907300.1"/>
        <property type="gene ID" value="SPAL_0000907300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF13">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000907300.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27177" checksum="EE14EA2F26253EE4" modified="2015-12-09" version="1">MSIDVNMCGIKKNEDEYELSLIMSPEKNIIVVGAKEILIKCTTREEKSFSEIPENDEIVISLNSNPNISNKLHFSPITTSTLTGNGSTSKISLQILKQHNMKGLLTTTAKIGEPLTLLVHLENTKLYNIILSDCYAHDGKGNDKAILKIIDSQGCGVPLARAVEEEVTTQIINDNEKNIFINIYGFQFTSNKNVFFECKIKTCIQPCNVKQCKKNTKNDLNKESEEKDFTNLVVKYMLEIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTM7</accession>
    <name>A0A0N5BTM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BTM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000920600.1">
        <property type="protein sequence ID" value="SPAL_0000920600.1"/>
        <property type="gene ID" value="SPAL_0000920600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="14"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000920600.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27313" checksum="D5A59A39E095DC9B" modified="2015-12-09" version="1">XSYNVSIKPSSSKEIVFCIVLQLLCGIQISVFFTSMWQYIVSVVPTFSMHFYGLLIAIFSVGQAISSPLFGALSNKLGSRNKIVAFALLLMASGNLLYACLVNLKTDWVPVAAVAARLFVGVGNGILSVIRGFVATVGDKRKRSSNIAAGIGSFVLGVALGPTIPMMFSIFGSKGYKVMGMVINLFTAPAYFNVLLFLIMTIILIFFIDLSDKHLNLSDTASLISTADDETGSTRKEEVSKIRLIPTISCIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUL5</accession>
    <name>A0A0N5BUL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUL5"/>
    <dbReference type="WBParaSite" id="SPAL_0000953600.1">
        <property type="protein sequence ID" value="SPAL_0000953600.1"/>
        <property type="gene ID" value="SPAL_0000953600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000953600.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36088" checksum="28B7559124BE3599" modified="2015-12-09" version="1">MLENTNNTILGLSVNRDYFNSALLNTLTCTLSQGTIFHLTYITAYRKPFMVPGNIRTIFLTIMLLASFNNTVILLLQACYFMGYFSEGAMSLKLSNFFQAFSNLTYYLIFTAPLFITIWRYYNIIMIKKLNTGKAVILYMAIILPGLCVFIDNVFLSKKFAISEPFTIRFDVSLEISKAIQKYYQTISIIFLILFSCLLIYTLNKIHQTLKTSKSLEVCGIEIWITIAYLYHAIIPYIHWIVTTILIYLTETEKIDIHRNIWIGNEIFIGLFVILFPYTFVLFLKPYRKMILEKFKFYKEPDTLSSYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVN4</accession>
    <name>A0A0N5BVN4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVN4"/>
    <dbReference type="STRING" id="174720.A0A0N5BVN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000989000.1">
        <property type="protein sequence ID" value="SPAL_0000989000.1"/>
        <property type="gene ID" value="SPAL_0000989000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="192"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="282"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000989000.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="72622" checksum="32672ED2F24E5FE0" modified="2015-12-09" version="1">MTTLIVGMSINILRSNKTKQSATVVNINKDVGHVKVRFVESDGSFKSKTLSFQQVLSWNPELSLQTQSSSEISFISTSNHISQTSFSSNTTFRERNLSSLNESSFNESFTSVVQKSPTESMSPTSQETIIRPLCKTLKSGINFNESRGNNCKNFPSIPKNHPHYDYYKLIQEEISCVQFSPLEYFVDNEDARMKVFVRVRPLNEIDVSNQEIEIINIPNSQSLIIHQPQAKVNMQKYINTISFQFDGIFDAKATNECVYENTAKNLIQSFFNGNCVTYFAYGQTGSGKTYTMNGEGLGVSSNGIYSSTCKDIFQQSSVNYMNRNGYHIECSFFEIYMNKAYDLLNKRVELKVQADQNDDVKITGIKRVRCNKPEEVMKLISSGSKLRSTGQTKANAQSSRSHAIFQFYLTYDEEIISKFSLVDLAGSERGVDAGNVDKVTRNEGNAINKSLLALKECIRYMSSENAERIPFRNSALTQFLKDSFIGKNSKLCMITMVSPAISSCETTLNSLKYAEQVTKICPRQQSLQNSECFNYSSTYSSKIDQSFNNNSMSEVSDYSHFEIDTSKYDNSMEILSSMQGLISSYEKQLSHCITMRSVLNGGNVNTFHDALKNISQSDVIDRLKNLKVQLCSSIKKAEFKSEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVP6</accession>
    <name>A0A0N5BVP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000990200.1">
        <property type="protein sequence ID" value="SPAL_0000990200.1"/>
        <property type="gene ID" value="SPAL_0000990200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000990200.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9653" checksum="A13295FEBEC7231B" modified="2015-12-09" version="1">MATEDTSRRILIQKLLVISLICNHFIFVRYMVSLLYIYLGNTIHTYEIIMIGKIFVTHPLYIYFLFCNMWKNNYIRPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVT9</accession>
    <name>A0A0N5BVT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVT9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000994500.1">
        <property type="protein sequence ID" value="SPAL_0000994500.1"/>
        <property type="gene ID" value="SPAL_0000994500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000037">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="293"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000994500.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="42020" checksum="2A61E69936F2FF2B" modified="2015-12-09" version="1">MTACLIEMESTDNQLKRRLSMESIDSNLYPSSSINSQSPKENVRTLFVSGLPFDTKPRELYLLFRAYPGYENSQLKITSKNGKTASPVGFVTFSSKNEAEEARRQLHGVKFDPDSNITLRLELAKANTKSTRSKTQLSSPTTLIMPPPVSISHTNAGAAYAAAVGLYNPQSTTISTSPYSISTPLIGHSATGLYSELGGYDMGILSSGDPNTNLLLSSLTNLPSTIGYYSTQSVGGGKSQRSSPKSNVTISPHSHVSLAAAIAAQNSVVAQAAGGAFYPSNAYSQISFNNPCSTLFVANLPGNVNEDELKSLFRGFPGFLKLKLNIKNNNNSKINENTIPLNAVAFVEYGDVRQATQVLHSLQGFKLTNSERGGIRIEYAKTRMGDINSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW79</accession>
    <name>A0A0N5BW79_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA photolyase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW79"/>
    <dbReference type="STRING" id="174720.A0A0N5BW79"/>
    <dbReference type="WBParaSite" id="SPAL_0001008200.1">
        <property type="protein sequence ID" value="SPAL_0001008200.1"/>
        <property type="gene ID" value="SPAL_0001008200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="13">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001008200.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="51020" checksum="5C8BE867A554FE2D" modified="2015-12-09" version="1">MNFVMDNRTSFITQFGDYKNTLYLIQRDNRIFDNHAFNLAVELAEKSKGSLYVGTELNKIKMNERQKVFLMEGLQELEKACIAHNIFFYLINDIDEFIELKEISCIITDFSPLRENTKYNEELEEICQTKKITFGICDAHNMVPCKLLKVYKKTGKAVKAQLFKYWDDYFEDMPAIKPYKYNNIDEVMEVRNNFIYKSKDKCSSFKGGYTAGMKEVEEFFEKRFSKFSSMRNNPNVNAQSNLSPWIHSGQISSQKIIFMACKRFKKNDVNLSSFLNEIFAWKEIAEHYCYHEKNYDNLDGALPWAKETLLKHKNDKRDEVYSSEDLEAGKTKDPLWNAAQKELLTKGKIHGYVRMYWAKQLLKWKDDPEDALKITIELNDKYSIDGNDPNGYTAIMWCICGAMDQGFKERNIVGKIRPMSSLKLKASDYIQRWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY55</accession>
    <name>A0A0N5BY55_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY55"/>
    <dbReference type="STRING" id="174720.A0A0N5BY55"/>
    <dbReference type="WBParaSite" id="SPAL_0001071600.1">
        <property type="protein sequence ID" value="SPAL_0001071600.1"/>
        <property type="gene ID" value="SPAL_0001071600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF877">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733540" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="133"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001071600.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32745" checksum="5BAD621BE12C9168" modified="2015-12-09" version="1">MTKYIIINLLLFLCLTITLQLHPEDEKFPAQDRDNFEITKKAVEIIEKVEEKIEGKNENYSLMTQAENSKKDIYNFNTENTNFSPMQNPYLFQGDEMLTKNQAENLVDDVIEKARSYEIDLSGLLGENTRTKRKIQKDLNYTWEFPINYVVQGVDNEMVDTALKFIENETCVRFSKQKAIPSGQPGLKFVKGNGCWSYVGRSEESKFQDVSIGYGCTTVGTVQHETMHALGSTHEQSRADRDQYLTIVEQNVRPSLMYNFVKLNISNAIDYYIKYDYGSEMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY83</accession>
    <name>A0A0N5BY83_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY83"/>
    <dbReference type="STRING" id="174720.A0A0N5BY83"/>
    <dbReference type="WBParaSite" id="SPAL_0001074400.1">
        <property type="protein sequence ID" value="SPAL_0001074400.1"/>
        <property type="gene ID" value="SPAL_0001074400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001074400.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37827" checksum="9A663DA7E7400B7C" modified="2015-12-09" version="1">MRSAKSVKRSHISKHAYQNKSHKKKSAKKAIFAYKEWKKTTYSSEKNEIVVNFSSVIKHNAVYNAPQQKIETNKENLKTNKSKEESVKYQPKKKSNEKVNEKPKQKTNEIKKSEVKVKVRPEPKAVEQKVEKKNEVIDIVKVEEKERIVKVESIPVVEKKIDSVQIEVVENPLTVDVNTKNDDTGMKASVDSGIDFNNVNHSTGSPSPPQNKSGSPSRVSASGNSFFDSVNKIVQTALGSAENRLPTKLQLNHNGGSRQRTHKLLPRDIKFCVKMLEKFGDDFESMSKSEDNVYMDTPSGIKRKIRTFKESPYYEQWQKAKIDGKSIDDILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZG6</accession>
    <name>A0A0N5BZG6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOB kinase activator-like 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZG6"/>
    <dbReference type="WBParaSite" id="SPAL_0001115600.1">
        <property type="protein sequence ID" value="SPAL_0001115600.1"/>
        <property type="gene ID" value="SPAL_0001115600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001115600.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27439" checksum="44677424CD7245F2" modified="2015-12-09" version="1">MHRKLLEKYINMSKSSALNFFEFLHLNKDKTFRPKKKFRPGTLRYNLHKRATATLKSGIDLKEAVKVPSDDTFEDWLAVHTVEFFNRINLLYGVIQTSCTSETCPIMSGGERYEYLWQDGDKYPKPTQLPAPEYVNNLMEWVEGKINDERIFPPCVSVPFPPDFKKTCKKILTRLHRVLVHVFIHHFDCVRLLGVEPHANTLYKHFYFFVTEHSLVSSKELDALKGMTNALITKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZX2</accession>
    <name>A0A0N5BZX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZX2"/>
    <dbReference type="STRING" id="174720.A0A0N5BZX2"/>
    <dbReference type="WBParaSite" id="SPAL_0001131000.1">
        <property type="protein sequence ID" value="SPAL_0001131000.1"/>
        <property type="gene ID" value="SPAL_0001131000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895169" evidence="2">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001131000.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23560" checksum="5CABF981CDC62F71" modified="2015-12-09" version="1">MNFLPFFISIFVIPAILAQSSLEPVSGTKCAKNQVVNKVTVYEDGAIEAECGPIPCATSGDTCVDDQIACKAERDIFSGMKWASNGQSILLRCCNLNVTNKLYVGTDLVTLGSYYTGGPVAKKDLYGNGGAEYDFVANIRTEQGGVRLWVYRILCPLQQETESSATPSSQITDGRNFAYEKRRQYLLRQLSQSQQQSSGDLRNEAMVGETRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0R8</accession>
    <name>A0A0N5C0R8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0R8"/>
    <dbReference type="STRING" id="174720.A0A0N5C0R8"/>
    <dbReference type="WBParaSite" id="SPAL_0001159600.1">
        <property type="protein sequence ID" value="SPAL_0001159600.1"/>
        <property type="gene ID" value="SPAL_0001159600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001159600.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="59011" checksum="D7801D0E96E19FBF" modified="2015-12-09" version="1">MDVGQPEIHLSPIFPKPSEKSIVNEDVDDFLFNELTGKRVHGFNIEKKLGEGGFGVVYKCNATTKKGITINAAFKAERNTSPNTPSMGLLFECKVLQKLEESDNNSNFVSLYSCGVRRNFTFMVMMLLGPNLYDICCYLPGEKFEQSTWIRVSYQILQAVKSLHSIGYVHNDLKPSNFTIGDKDDENGCTIIYLIDFGLSRVYGTKESPRPPVFTEEKRGIEYIGTITHCSPNAHKRVELGRRDDMYAWMYLMMDFYNELPWRRCDTDKKIEDFKLNCDYETYCKYLPKSCNAIIKHILNLSVYDEPKYDLLADRLKKIMKECRIRMDDHYQWELLPIEAKKALNLKIELRKIKKSNNRENNLSSKRHSRKGRNDNDSTRKSNSRKRIARGYSPKKQTRRSIKDPTSKKSSPVGNKDINSPNKPKESDGSPMNNKNVGLNNIFINISNLIGKKGNKKAKANLTVDDVHQKDTLTQDFNNIGGQNVDEKIDKRHKNKKVKDKGDVDCDSPRNNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0W3</accession>
    <name>A0A0N5C0W3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0W3"/>
    <dbReference type="STRING" id="174720.A0A0N5C0W3"/>
    <dbReference type="WBParaSite" id="SPAL_0001164200.2">
        <property type="protein sequence ID" value="SPAL_0001164200.2"/>
        <property type="gene ID" value="SPAL_0001164200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001164200.2"/>
        </source>
    </evidence>
    <sequence length="544" mass="59685" checksum="7F8B543CB299E97A" modified="2015-12-09" version="1">MDYSLNNISSTKRRRNFISNMNGDVESNVETNFDSEQLKKLMKEVQELKTIVQSLFDCKKKPDNENILSTLGISNESRKRSATQSSFHPECPPPIAPVQNHISSSLLQFPWSLLQGTIPCASPNNLNLAMMDSLNFDGTSNTTSNISGGRWNSPTLLESVRKIETNSINSGDNSMPDSLNYDGTDITSSTQSNNTHQMLLMMNRNNIQNQNLLSSMSVSQVASDLAKVGTSGSLQQLVQQIQQQQAAAAAVAAVTAATQSQTSPTSQVQTATQHLSSIAPVVTAALTNPSLFFPLSIQSNNNNHLIQNNGRLLTATPHQNNSCGSNSSSSISSISSNNTTPIVVPEKKKQVSDDFVKIIRQNDLSEDRISRIEIPVREALLVDSSFRPSSEQQIIQIVLKNKKVEELEISEVMTQLCKKLAEKRVFGSKLMAQTTVAGPNHSTYNNLPIEGIIYIQHVCRKVLGAKVRSEDEFWDVFRDAMRKLAARCRRVRHARKTKSVLENSISMKKEASSDSSGDSTSDNHLNSSGDSSSTLLLPTLAQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C102</accession>
    <name>A0A0N5C102_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C102"/>
    <dbReference type="STRING" id="174720.A0A0N5C102"/>
    <dbReference type="WBParaSite" id="SPAL_0001168100.1">
        <property type="protein sequence ID" value="SPAL_0001168100.1"/>
        <property type="gene ID" value="SPAL_0001168100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF274">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001168100.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="33828" checksum="EA6229F7F835397C" modified="2015-12-09" version="1">MEIVKISITFCICICLGVILICLTTTSLMFNEISNFYDEAVGELVEFQDITESAWNDIIKIIDNTKNDEIVHKNMFPILSRKKKDIDGDDNWPPQCACHWSPTNCPPGPSGEPGIDGTPGDDGLPGPNGIPGSDAVRVYVRRGTQSECIRCPVGEPGPQGSKGLPGPPGPKGPPGERAYSRGGGLPGPPGPPGEPGLPGRPGEMGEPGAPGRPGFGRQRSVPGPPGPPGPPGDDGEPGPPGLTIDGDGGFRGPNGDPGLPGLPGDDGAPGAPGEPGKPGNDGGYCKCPPRNSLPKGEKNVESTFDAAIEEAPSRITSEYRTEKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1F4</accession>
    <name>A0A0N5C1F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1F4"/>
    <dbReference type="STRING" id="174720.A0A0N5C1F4"/>
    <dbReference type="WBParaSite" id="SPAL_0001182900.1">
        <property type="protein sequence ID" value="SPAL_0001182900.1"/>
        <property type="gene ID" value="SPAL_0001182900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895197" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001182900.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="21890" checksum="59843C86ED56B2FC" modified="2015-12-09" version="1">MYTKFIVSLTVIAIAYACTDGKDNVVDVADYSNGAYNVHFQNAQGQVYASDGTPSCYKGEANLKLPGQLKLVSGTLVVKSNMNLMSNVEAKLTLKKDSSIIGKICENGKSKNILIPDKDCTIALCNNAMEDPLCTLLEKAGTYDLSQIEKTLGITATLSLPALPSSFKGIIKGKWEAGVSLVVNGQVVADIKLPSNEQFIYVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C328</accession>
    <name>A0A0N5C328_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C328"/>
    <dbReference type="STRING" id="174720.A0A0N5C328"/>
    <dbReference type="WBParaSite" id="SPAL_0001238300.1">
        <property type="protein sequence ID" value="SPAL_0001238300.1"/>
        <property type="gene ID" value="SPAL_0001238300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="279"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="437"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001238300.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="91590" checksum="0C1374DF5C38700B" modified="2015-12-09" version="1">MNYLQHHLKNSLKTEDLSNNTFNSTNFIINNKFNNQFPIRLPVITYYGTSLNYEFSVMSNSIQAPSNTLKPYHNNNLNQNTALALYYYYLQNSTTSQNDILNPQHFIESNKFNQKVFENLILKSYYPPDLPSSPTNNKETSTKDSYIKLLDYSNKKKQKSCKDDAPISNTNDPDNLLLYNLKYPFLCNDFTYKPNLNDPKMAQTKNKSPLKIPTSPLEDKIYNNSLSLTPIEKFSWVRHYGIDIENLYEYNNCSEEINNYDITSTSNKYAFKNEIDRENFICAICGDKSSGLHYGIYTCEGCKGFFKRTVQNKRVYSCVSGSGCCPMTKEHRNRCQYCRFKKCLKKGMVLEAVREDRMPGGRNGSAIYNLYKLKYRKNKRSSGSEMKDDNSDKNNCLLNLNSCEEGDGSRLPRKWSRQEVPEICSPSQSSSSISSISPSEITKHLPAAPSIESVCDPESIERFKATPTPRNLIHEMMEIDRLDSLINLKGLRVASNNALLNQEEEPIPACQRLSRIGDEIVEQLVEWTKMLPFYNDLPVEIHTHLLTQRWAELVLLSACYYAISNCSPVSENNISTIVIKKDNHNYLSHSPLSHSSSSSIFSEDDLTPTNFYNNISSTSVNGLTEGHDEISFSDPSINLVILQKRLSLIMHKDIPMEHVVTEAGPLVEKFTALLNSFAKLKITYEAYVCLKAITLLHYTPPSGSVGKIGTANDNNGRSNQMSNIKKVSIIQDQFVKALQIHLSQCEDGPRLTDILTWLPMLHQASSVLLHSKMFYVPFLICKSPQSIAASSINNVNTESISDTDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3N6</accession>
    <name>A0A0N5C3N6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3N6"/>
    <dbReference type="STRING" id="174720.A0A0N5C3N6"/>
    <dbReference type="WBParaSite" id="SPAL_0001257700.1">
        <property type="protein sequence ID" value="SPAL_0001257700.1"/>
        <property type="gene ID" value="SPAL_0001257700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001257700.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40358" checksum="67D91298CA11032B" modified="2015-12-09" version="1">MDQRQEGKSDVPIDHLCNVQGKLKKFNYECSIENFSQRPEKTGERIESPTCVVGNNDEISVWCLYIYPHGSNESSKDFVSVYLNLLEPDRAKVKYYKLSILDDKEEEKHIRMNRVIEFNNRGWGFTKFIKRDVLLNESNGLLVNDKLTISCEAEIIGVNFENNNNSETSENCSKPQSNLSLDLGNLFNSQMFTDCCIKVGETTIKVHKGILATRSPGFHNILSSTPENSQINVIEIKNFRIEVVEKMLRYIYTDDISDIKDMASEILAIAAEYGLDGLKAVAVECLCDDLTIENVCELFILSETFGSEELKERCEEFIIDNSEDLKKTDKWVELVRNHPFLIESLFWKSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3X3</accession>
    <name>A0A0N5C3X3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3X3"/>
    <dbReference type="STRING" id="174720.A0A0N5C3X3"/>
    <dbReference type="WBParaSite" id="SPAL_0001265700.1">
        <property type="protein sequence ID" value="SPAL_0001265700.1"/>
        <property type="gene ID" value="SPAL_0001265700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033930">
        <property type="entry name" value="FAM43A/B_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF2">
        <property type="entry name" value="FI05246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001265700.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59819" checksum="F9AEF568652099A4" modified="2015-12-09" version="1">MPSLSNIKETALFNLPFKKKRSYTINPPDDHYNVTYLGNVLTIIGKGNASIEKPLNLIWKTFCQKGQRCDMPMKLSVTRSGLKAETKQQGLTEYLPHRITYCIAPPAYPKLFCWVYKHEGKKMKPELRCHAVLCKKHSEPMLISSRLTDFLHSALQEYKREKILMEKARKNSIFNGPCPKRKLILQTGSLNFRPSISKNKALSRLGSINEEEEIIDDIQNKINLIDEEKLEKITSQTIIEKNEIKNSTCDYFDDDLLEEDEEEEESFSKSCPVYYLPSTSGISSDDGEFSITFSNTQIDIFDKNNSSVKLKRNFSLTKNKKEIHKESIEKILEKQKNNYGLSSSLNNISSKENEDNFPENQVNFNNFPTSSTLLDTDSVTKTVNFCKQHNSNEKFVKNNDIEILLEEDDLSSYEKSRTPSVDFESSASSCSSIDDGFNISDLSKLNNTKIKDDFSECTLSKDKDVDCISDESGYHEETFRRMYQEIEKNVSVPICNAIQANTIKKIDVIKKDKYADYEVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4H1</accession>
    <name>A0A0N5C4H1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4H1"/>
    <dbReference type="WBParaSite" id="SPAL_0001285300.1">
        <property type="protein sequence ID" value="SPAL_0001285300.1"/>
        <property type="gene ID" value="SPAL_0001285300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001285300.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57872" checksum="3306159C52170A01" modified="2015-12-09" version="1">MQEITDEMMENRKKHYKAENYQLEYSRGLSQPIYFSKILKGQKIDKYTKSYCHDNIERSVNVYKLSLTDDFLKSEKYNDKLVLSINEVVRKVKIELYISRPYANLIGDSFEVLTKHLFCNLRYCEIGFFHSCDRNSQNSGIFGALLTVFRSEMFGYYYIGFTSSNEYRNLILKLIPKNNDNKHVFNVVFCPGENWVHKRSEVDYFLDDSNLVGAILMDNSTRRLFLKLAYCHNNNNKIFIKCGRLDQKYMSSIDVGYECNDYNKEEANRIHNKDEKKTDMLVISNDILMCNGHNIFKSSSIIISVLPPENNFNKAGIFKVSKVNQTTNLYPEQELQLIDVNDIIKTHSGATEYLGYVVNYEPKCRVPYLNVKLYLKISDTIQKFENKANDNFGKIDTYVVDRKGINSVPVGCHVVFDEKKHPAFNHFYENCCQPSLLMFNGKTKKFIEITDIQSFQPNNMYKCALKVKNANSKSGQQKYIHETDFTINLIDPSLNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5J8</accession>
    <name>A0A0N5C5J8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5J8"/>
    <dbReference type="WBParaSite" id="SPAL_0001322600.1">
        <property type="protein sequence ID" value="SPAL_0001322600.1"/>
        <property type="gene ID" value="SPAL_0001322600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001322600.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11271" checksum="9ACD1BD815BB9D3D" modified="2015-12-09" version="1">MTKFSKEFILSTVQKFTQEHFTDNDLPRHQNLLEFIKQSLVEKPSNVENPAIIPNGTIVFKKESSAHKRDEQYFGPFIITEGIYRDAYQFQQIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Z7</accession>
    <name>A0A0N5C5Z7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Z7"/>
    <dbReference type="WBParaSite" id="SPAL_0001337300.1">
        <property type="protein sequence ID" value="SPAL_0001337300.1"/>
        <property type="gene ID" value="SPAL_0001337300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001337300.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29544" checksum="E9EF8CE94D48277D" modified="2015-12-09" version="1">MFSSIFSGISSLFRRTKKVEELANEVANDNSTIVSETEEKESSFVNQRKRKFDFSNDEFECSDIRKNIKSMLNCTSIGGKKKENYEHLKNASFFNETQCNNLVTESKRFKSSKKKETYLRAYTDDYSVSADRKIIDAFEILHDGIVEACEKFPHAKLLVLGDNPVYQNFLKKREEDENFLDSIESYRIRKLVTKIVMLEFKHDITFDETGSTFAQGVLEISAKGEATVECFNKYNNFLTSYEYYKRYMDDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6A5</accession>
    <name>A0A0N5C6A5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6A5"/>
    <dbReference type="STRING" id="174720.A0A0N5C6A5"/>
    <dbReference type="WBParaSite" id="SPAL_0001347600.1">
        <property type="protein sequence ID" value="SPAL_0001347600.1"/>
        <property type="gene ID" value="SPAL_0001347600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF50">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="35"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001347600.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57375" checksum="626AF05099968228" modified="2015-12-09" version="1">MQRNGDSNNHLITYYNDMTNFINLLKKEGRIIPLILSSIFLSISPVGYHIVVLNVPGTIIQNSINESIFNNFEIKLNDSQLGFLWSLTVSSQAFGALIGCFSVTYFVQKYGVKFTMFYINNIVLIVSSLLMFTSKYIFTFFLLFAGRVCVGLYTGMACGITPMFIKEVSPRHIKGALGCFLHIAVCIGSAISAILSLEFILGGPNTWGFLLLIPIFLGGIQMWIGQKMPDTPNFLLQNCDIRNALSSIEYYYNIKQRSSDEILSKYSELVSNVPSQISIKEAFNDYNTRKGIILGMILNAAQIFCGSMASVSYSTFMFNSVSFSKLLTPFLPAIGSLISVLLTIPAIRFVEMYGRRQLIIVTLIICGSANYLMTLFSLLSQSKVSANWSTYAYSLTFLLMGIGYNIGIGPLAYFVPEELVHPRASSVALGFSICINWISTMTTNFIFYPMNIVIGGYSYLLFALPTTLFTIFLYFYLPETKSPSYDSDGETLTCNLLQNVYDDELTYGTFYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C766</accession>
    <name>A0A0N5C766_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">40S ribosomal protein S24</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C766"/>
    <dbReference type="STRING" id="174720.A0A0N5C766"/>
    <dbReference type="WBParaSite" id="SPAL_0001378000.1">
        <property type="protein sequence ID" value="SPAL_0001378000.1"/>
        <property type="gene ID" value="SPAL_0001378000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001378000.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15050" checksum="A5DA3D7FDF3EEC63" modified="2015-12-09" version="1">MVISTSGAVVISTKKIVNNRLMNRRQMLVDILHPLKATISKKELQEKLAALYKTTPDVVVPYGIKSQIGGGKSSGFAKIYDSLDDAKRYEHKYMMARLTGVKLEKSGRKQRKERKNRQKKFRGTAKVKGAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7U0</accession>
    <name>A0A0N5C7U0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7U0"/>
    <dbReference type="WBParaSite" id="SPAL_0001400200.1">
        <property type="protein sequence ID" value="SPAL_0001400200.1"/>
        <property type="gene ID" value="SPAL_0001400200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001400200.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19536" checksum="7638E0C086DF5295" modified="2015-12-09" version="1">MILKNIIIIILFIILFNIIDVENRRSKRERPKLRVWGRIDCRNRHVKNMQIGLYQYSALRLLVRLQKVPCYCEQYFDIKTIETLFPKSRPFLVLKYFYTDGRLGCDTKAILKLPHPYDNNPYKFGKSYHMGTINILKLFYEYKKCHRIKNRRWFKPRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C817</accession>
    <name>A0A0N5C817_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C817"/>
    <dbReference type="STRING" id="174720.A0A0N5C817"/>
    <dbReference type="WBParaSite" id="SPAL_0001407700.1">
        <property type="protein sequence ID" value="SPAL_0001407700.1"/>
        <property type="gene ID" value="SPAL_0001407700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001407700.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16165" checksum="58445AA87ECB0337" modified="2015-12-09" version="1">MEEYTREPCPFRIGEDTGSGFTMGLIGGSIFHAISGFRKATDRQKFKSAYNNVRKKASLTGVQFAAWGGVFSTCDCTIAAIRKQEDSINPILSGGLTGALLACRSGPVVMVSSAFLGAAILGMIEGAGLIMSRYVGKMYDPTIAQPQAEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8D8</accession>
    <name>A0A0N5C8D8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8D8"/>
    <dbReference type="WBParaSite" id="SPAL_0001418900.1">
        <property type="protein sequence ID" value="SPAL_0001418900.1"/>
        <property type="gene ID" value="SPAL_0001418900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001418900.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10282" checksum="DA6D1D69C1A8553C" modified="2015-12-09" version="1">MNFTKTVSQRVLTALEKAKIVCWFEETNSFAIVKRRYVSEFGMEPPSVELVKNLHKRFLETGNVADVPSKDTIPMGVLHKPFNFGGSPAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Y8</accession>
    <name>A0A0N5C8Y8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Y8"/>
    <dbReference type="WBParaSite" id="SPAL_0001437100.1">
        <property type="protein sequence ID" value="SPAL_0001437100.1"/>
        <property type="gene ID" value="SPAL_0001437100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001437100.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27905" checksum="883730613CE32FBD" modified="2015-12-09" version="1">MEEEISIRMTRSSTNIPWGVGFRQNGNEVVVDFLDKGSIAEKAGLNRTDRLIEFQHSSLRAPDAHSISRDLERLLEVSMKLKRFVSFPQGIPWNLNGNERNIEFNTFDEGHKKFHDSDRFQLLGGYNSNQNFDNTYNSNYYSHSNFSHHEPSFSNYNRSSNTNGGSPYTMDHRTTSSSPYYGHREPYQYNPRNYNNVSPDARLTNLYGNYGQSNDGGHIIHHSSIPQSDCFKRISKALGTPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAC7</accession>
    <name>A0A0N5CAC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAC7"/>
    <dbReference type="STRING" id="174720.A0A0N5CAC7"/>
    <dbReference type="WBParaSite" id="SPAL_0001484900.1">
        <property type="protein sequence ID" value="SPAL_0001484900.1"/>
        <property type="gene ID" value="SPAL_0001484900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001484900.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11390" checksum="B106C115569D8746" modified="2015-12-09" version="1">MHGIVTYILKSTGIFKYSTEKIPGPKAVPIFGNALSFMGTSDDIRKKLDEESAIAFKNNDPLRRSWIGDILLIHSLSSEATKIIYDSITEISTGRSYNFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAS1</accession>
    <name>A0A0N5CAS1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ELM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAS1"/>
    <dbReference type="STRING" id="174720.A0A0N5CAS1"/>
    <dbReference type="WBParaSite" id="SPAL_0001499000.1">
        <property type="protein sequence ID" value="SPAL_0001499000.1"/>
        <property type="gene ID" value="SPAL_0001499000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELM2" evidence="3">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001499000.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="45505" checksum="25F04068D3F706C8" modified="2015-12-09" version="1">MDGQIKGQEVPSRKRKKTSERSFLEELQIRRSTRIQHIPEESEFYWLAAKKDSTGRHDYTQKLKVGPKHQVFVPEFKANRKNSQPQKTTEILIWDPRQDNADEWSIEKQAIVHEFADAVEDYGYDYLEALNILRQCNCDPLESSRYVEAYIPHHSFKPFSSAEELLLKNCKKKANKPQKKQQVFQQMVHESKRTHKEIVEHYRKTKKHTCESVPRRKKCWCKERLIIKPVRNIIKRQDCKNCRDRLYLNSILDLRIYTDSDKTFPLCSLCKFYYNHTNKMRVPVVEFDPSEGDKSEKKQEINGEIEKTDIPESHVSLILTELEAHCLDIDSTVTGLRENHGIVTYTHSHIRWFVTTQAHKYNIHFNNSFSEGHTVERGNLETEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB69</accession>
    <name>A0A0N5CB69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB69"/>
    <dbReference type="WBParaSite" id="SPAL_0001513100.1">
        <property type="protein sequence ID" value="SPAL_0001513100.1"/>
        <property type="gene ID" value="SPAL_0001513100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895739" evidence="1">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001513100.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23099" checksum="B076A5C0A0081D70" modified="2015-12-09" version="1">MFAKLVVILLIFSQIHGNDLEAETPLSGTQKGLELDNMFRGLILSNQIGDTTNYTHKETIGGQGYVDDCLSSDPISIDISFNHIKMHLFYDNFTQSRTIRYQIRCYLKSLVFAKRISIREIRLGPLMHNDSIIDDGDCEKLKRVIGKSSKNEMYFIITGTPKKCDNFIGLGIFVMLNPMQNGRPYPFKNNNQFREFKKDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBE8</accession>
    <name>A0A0N5CBE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C5HC2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CBE8"/>
    <dbReference type="WBParaSite" id="SPAL_0001521300.1">
        <property type="protein sequence ID" value="SPAL_0001521300.1"/>
        <property type="gene ID" value="SPAL_0001521300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001521300.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18340" checksum="C2DFAE47FFE69D2E" modified="2015-12-09" version="1">XTKEQTVKFKKRNEDSESSSDSSIDILVKREKVDNEDTGDCVGSDEDNERKEEGFVLIGKESTCNRCKRVITVLCLIPGCPCFENAQSDCIKYFNGTHEAPKISILHQLSGRSQLMAMRLLKHQIQSTQQSILMEKGILTWSSCSFCWSWFLTMGRKDKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBM8</accession>
    <name>A0A0N5CBM8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rad21_Rec8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBM8"/>
    <dbReference type="WBParaSite" id="SPAL_0001529500.1">
        <property type="protein sequence ID" value="SPAL_0001529500.1"/>
        <property type="gene ID" value="SPAL_0001529500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529500.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51723" checksum="1670BFD5748C891D" modified="2015-12-09" version="1">MNITNEPFYNTSGSLNDNDVNINGCNCINKGTGYKVDLNELSNIISKNINQSYVGKLKITKFSTIISINDISFKDNLNMAVIQNERVQIQMKIKDESVKAFVEEVINMENDCEGLLIFTTFNVSEEGMINELFLEEFHKINNLLRSIKIFNLEKDTMEKALEVGLFDTAGLDLSFKENKFSNLSQEKSDYAINTPIFSPNERETAVFLFEGDEFHDLPQEPDYAMNTPIFSPNEKETAVFLFEGYEFHDLPQEPDYAINTPIFSPNERETAIFLSEGNEFHDLPQKSNYIVNTPTFSPNEMETEVFLFEDNDKLQEEISGVRNTSNLLLNESVMSLSGSEHSDGTPKNRFNNSSAGNTRKRKGSTIEMDSHSTKKKKLSPIVLNQHIYEIIYTLQIPDVIDAVEAGIDSSENGKVEIETIRKFLGAKRLELSRCLLQMRNNYSIVDGLTAVVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBR1</accession>
    <name>A0A0N5CBR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBR1"/>
    <dbReference type="STRING" id="174720.A0A0N5CBR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001532500.1">
        <property type="protein sequence ID" value="SPAL_0001532500.1"/>
        <property type="gene ID" value="SPAL_0001532500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001532500.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49233" checksum="80D22C2C6E1B67CC" modified="2015-12-09" version="1">MSLPVNNKSITKGYSELSRNEWLMFIVLIVSNILGPIAFSCIAPFFNDVAISKGMSLSESGVIFGIFHLTGALLSPIIGKHIGRLGAHFMFTYGCLVTGFSTLLFSITIYLPTKNIFFIGTLIVRFLQSLGRAMFYTTTFSIVSTQFPDITSSMLGYIETVSGLGYNLGPVFGGILYDMYGYQMLFIILGPIIILNGIAAYFYIENKPTQEKKLKIDDCQKKFNYKKSIKMTGIYFLMIITMICGFFFCYNEPTLPIALKPFNMSHTQIGTFFLIQGTVFSIFAPIWGLLLDHLPITNTLLLTGNILLTISLFLFGPAHFIPLQRTPITVGVASIIQVTALAACYVPCFKQSMNIITNEYGYPNDMNTSGILSGMFTCVFSLGGFIGPTIGAILVQYYQYTTASTIIGYAHGVFVVFFIIFYLIPRFCSKPRKSTENTPQVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC76</accession>
    <name>A0A0N5CC76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC76"/>
    <dbReference type="STRING" id="174720.A0A0N5CC76"/>
    <dbReference type="WBParaSite" id="SPAL_0001548500.1">
        <property type="protein sequence ID" value="SPAL_0001548500.1"/>
        <property type="gene ID" value="SPAL_0001548500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895767" evidence="2">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="3">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001548500.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18071" checksum="C0D1ED6EA7E33FE2" modified="2015-12-09" version="1">MYKHIYFITFLLIFLYTYVVYSKKSSEFPLVTRGVKKTPLDYEVNIIHNDHNKGNVTTSNKQFTNSKKDKTKNNKSITTSKVTTKDTQCNNDTLKKILKNNILETASVSKRAIYHTAVSEMGEYFNVICSEHSFSFLANAQTFCHQTVKKISCLAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCI6</accession>
    <name>A0A0N5CCI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4150 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCI6"/>
    <dbReference type="WBParaSite" id="SPAL_0001559300.1">
        <property type="protein sequence ID" value="SPAL_0001559300.1"/>
        <property type="gene ID" value="SPAL_0001559300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001559300.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24699" checksum="B13F9895DB569DD6" modified="2015-12-09" version="1">MEETVIKESDKFVIFIIVDNNGARPGIQGENGGVYDYGAGNRGGTESGAGVGINQYGQGSGNFNGNTQGNGQGMNNNMGQNIGNENNQNNGGGTYPNGNQNVPPNRNPNQPRVSKFFSNPVVGSVLGIGNMITIAIFFQLTLSKILGAGIGGMYALNHNKMMMKQYAMMNGITKSLFLLVILGQNPYEMRIRNSMMKQQWKDDARRFRNENSKKLFNIYEIYKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCY7</accession>
    <name>A0A0N5CCY7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCY7"/>
    <dbReference type="STRING" id="174720.A0A0N5CCY7"/>
    <dbReference type="WBParaSite" id="SPAL_0000079000.1">
        <property type="protein sequence ID" value="SPAL_0000079000.1"/>
        <property type="gene ID" value="SPAL_0000079000"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000443400.1">
        <property type="protein sequence ID" value="SPAL_0000443400.1"/>
        <property type="gene ID" value="SPAL_0000443400"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000569300.1">
        <property type="protein sequence ID" value="SPAL_0000569300.1"/>
        <property type="gene ID" value="SPAL_0000569300"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000647700.1">
        <property type="protein sequence ID" value="SPAL_0000647700.1"/>
        <property type="gene ID" value="SPAL_0000647700"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001528000.1">
        <property type="protein sequence ID" value="SPAL_0001528000.1"/>
        <property type="gene ID" value="SPAL_0001528000"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001573500.1">
        <property type="protein sequence ID" value="SPAL_0001573500.1"/>
        <property type="gene ID" value="SPAL_0001573500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000079000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000443400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000569300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001573500.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11401" checksum="62964BC7A9EE1218" modified="2015-12-09" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRTVLKSFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE74</accession>
    <name>A0A0N5CE74_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE74"/>
    <dbReference type="STRING" id="174720.A0A0N5CE74"/>
    <dbReference type="WBParaSite" id="SPAL_0001616400.1">
        <property type="protein sequence ID" value="SPAL_0001616400.1"/>
        <property type="gene ID" value="SPAL_0001616400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="150"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001616400.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54427" checksum="DC80314F562967AA" modified="2015-12-09" version="1">MEESIDKKQSKKSARSIKSLGKIPVFTGNNSKNIEEQEWFHAMRPRGDVQNLVKNEGDWLVRVTDTRGFYELVITARGPKSKLINFTVGVCNEKGFFLNILLKTKNINYFSNIVDLVEYYKDKVLPGKIVLKNPIIKPAWLIKKNQIKYEVNCGEIGRGNFAIVYKGIFTNNANQSIDVAIKVAIIDNSDKVNNKNAKDDLLKEAKIMSFLVHDNIVHFYGIACDKPPVILVMELCPGGALSSHLKREENNISDLEKALYGYEICRGCDFLHSKEIVHRDLAARNCLISQEGIIKISDFGLSKMTTELKNENFWSQKIPLAWMAPETLVHNPRYSEKSDVWSFAVVLFEIFSNGAKPWPDMEPKKMATLIRKIKLWDMPSGTPKFILDIVNRIFKADPKARPNFKELASTFRNYVQEHRESCSAKELTVNKIKGVKRTKYFTNIPEREAFTSLLKINLKNSSKENDEDRNSSCTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF25</accession>
    <name>A0A0N5CF25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF25"/>
    <dbReference type="WBParaSite" id="SPAL_0001646300.1">
        <property type="protein sequence ID" value="SPAL_0001646300.1"/>
        <property type="gene ID" value="SPAL_0001646300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001646300.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30747" checksum="04201CEEF0831B93" modified="2015-12-09" version="1">MVGHLHWLHCNKCGIHATPNPRTTTKLFICSCQDVLCQKCLENSPTASSASKRNCILCNREIGFCLIGNTMEQRLQKFFVPAKNLTKLSLDDMTKVASFQMKQKDSSLKFIMSKYKRSEELVVAAKKKFAASNGKPGEEMTGPYEELQSLLKEEAELDKEIARMMKLVNAGAKKLKEEGAARALNSTGANSVHPVSTQGGSISYTPKSFNVQSLGRPFSGIGSSGVSRTSKVASNREAGNPSRSTAEKFFDPLISSTPILDGAKRMSLGRIDGADMLSPIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG41</accession>
    <name>A0A0N5CG41_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG41"/>
    <dbReference type="STRING" id="174720.A0A0N5CG41"/>
    <dbReference type="WBParaSite" id="SPAL_0001682000.1">
        <property type="protein sequence ID" value="SPAL_0001682000.1"/>
        <property type="gene ID" value="SPAL_0001682000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="10">
        <location>
            <begin position="125"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="9">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001682000.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="71746" checksum="96608F4E0416DD1F" modified="2015-12-09" version="1">MLLSASLSLIIGEFDKAEELFLKSSTPLKALDMRRDLLHWEKALTLADRLAPNDVPIISKEYAQQLEFMGNYKEALKYYEMGLFEENSDTTEEQYEHNEICNSGIARTSLKTGDFRKGIALASSIPIRSLKKECAMILEQQKQYFEAANLYELGNFYDRAAAVSLKTKNYGKVNDLLKHVRSPKIHSQFGKVMENEGKYQNAVEGYLKGHDYDNAVRVYLDHLNDPESAVKLVKESRSIEGAKLVSKFFCSINDKKSAIQFLVFSQCFKEAFQLAETENLIPVYEEILESYGTNVQFHQMAEYYQEKKNYTKCGKFYYLAGNYSLALEYLMRKDNKDDALLIAIDCVAASKDASLQDVLLHHLMEDNGGIPKDPKLIFKFYISMKKYKEAAKVAVIISDNEQLKGNYRVARDLLFQMTQELFKNNIEMPNTIKQSLVVVHSYLLVKPLMATKRPEIAGRLLIRVLQNISKFPSHRIQILTSTVVVCAQAMLFETAYNAAVELMKPENRKFIDDKYKKKIEQVARKRENASKGDVDEKYSNCPFCDEPVKEYSLTCFSCKQTLPFCIITGRHIVKDDLAICKNCTFPAFASEFNKLSVKICPMCGGNVSNYEIIDDISKLEFHTRNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG57</accession>
    <name>A0A0N5CG57_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG57"/>
    <dbReference type="STRING" id="174720.A0A0N5CG57"/>
    <dbReference type="WBParaSite" id="SPAL_0001683600.1">
        <property type="protein sequence ID" value="SPAL_0001683600.1"/>
        <property type="gene ID" value="SPAL_0001683600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="236"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001683600.1"/>
        </source>
    </evidence>
    <sequence length="739" mass="85193" checksum="5011C32BA957EFD1" modified="2015-12-09" version="1">MDFITKYIDVQDDNDRTMDVKSDECFENLSIPCEMIKKFNDMRIWKPSPIQAATMPMTLCGADLLVQAKSGTGKTLVFAAMSIIVTMETENYPQTVIVSPTREICEQIYSTLKQIDYKNLKIGLCCGGENSYKSQKSMIEGGVQIVVGTLGRLVQFINDGILDLKNVSTFVMDEADKMVEGNFQQDISLIFSNCNENKQTCVFSATYPQEILDVLSRFMIDTTMIRLDSENVQLLGIKQYVQFEVKDNEKGEFTTAAMLAANILKRQQFNQAILFLNETKLLVEFAVQLKKHIQEYSIQLMSGTMLQKERSKVMNELKNKKVKVLISTDLLSRGVDSQHIDLVVNVNCPVDCCTYLHRIGRAGRFGNYGASFTLIDNVKDLIKFTAMVDSEKLAVKYLSKDGLRNSHLTMDRNVFNESKDFNGDLVKDMCSDLCDVFKCGCYIDNSSEPVISYTRDEIMKIKDMKSINEWQVYAKEIFKNCSCIFYNIGRDRFVHEHKKENVRRNDAFDKFTKLRLKNDKFYYKEKIKKEENNYVEENGHSEIESTPSPTELTCDISEPKIEFNGKEKIDSQDLCVYSKDDLLKILNSKTNDQLRAIFIGMNLGKEVYKNEPVVMDSELRKPFALQLRILREREKERSRRLRKEVEKNEKRDKNFIYGKVERNWYHNVKFPSIPPKTKKIYQEVYNLATGNDRYSLPSINSILVSQSSIDEDDCGLKSRAEENKVLTQKWLMTQANSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGF9</accession>
    <name>A0A0N5CGF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001693600.1">
        <property type="protein sequence ID" value="SPAL_0001693600.1"/>
        <property type="gene ID" value="SPAL_0001693600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001693600.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="39003" checksum="3694FF7BFB3652AB" modified="2015-12-09" version="1">XEWIWDGNERGSGTAREAFCLRQCPQKFWSGAVNEKSKHLTKDINFLDYMTLRNIKILEVNVTKYDADYIGIHLQGINNDYNTGKQIFGVLYKNKDYFFKNPHTSCQMSYCENGLFFMSDISTEGMYKAKVDDFEEIFYLKFVTSDMNFRLNKLIIDGNNFPLILCPYKNWVSIKSVTKFIPFETNGIEFANLLERQILLPGYPRSDDSDIFVCGYIKYEDGSQLTISHEIEIRDYYKIDLIKQIKNFQHIWKCSEGERATNYHYFIYSYNVKGYNKMKHIKKDSMNENKFYYNDTMYLYNEDYTEGFKSVEKFMEVTTTKIQNTTCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGZ0</accession>
    <name>A0A0N5CGZ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGZ0"/>
    <dbReference type="STRING" id="174720.A0A0N5CGZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001711500.1">
        <property type="protein sequence ID" value="SPAL_0001711500.1"/>
        <property type="gene ID" value="SPAL_0001711500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="17"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001711500.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="65300" checksum="525F4202EADAE007" modified="2015-12-09" version="1">MSTSSRLVQNPTTLFEVFLEFRVSKLDDGTIIKEDMTKFPESYEENDKLRSIKDFAFPWKTTPNIENAIQLFTFVLTDGKGEFTFGHSRYNPRTSTCMCFLSSLPWQAFFIKILNYISKVLNEVGDAIESLSVIKNFGVPIPDTVLYTKEGSYQLAIPIPNKVLMPSIKDSKILLDFYNAMPEKNMEIYYISLLKERRIIFTGSKISQVSSCCFAANHLLFPFHWQGIFIPVLPPKLVDTLMAPMPYIIGLHKEIFEIVNMDILGEVVIFDIDDKSFYTPHQDDILPSPVLEFLKDKLKYLHDNFLTESLTKIFLSCNVLIFGRYMEGFLRGLDDKIFSWNRRLFTDKQHPALRPFISELMGKDGVQYFERFIVERIEIINSGKLREDLFERECVTIYPQLDKILSSKNNKINVEGAISTIKNKLIKMNIKDFTKASKHETPKKRFLKFNKTPSIVTNVMYQDNENEYISKLPVSNDPTLPNVPLDGTVNNTFIDHSNKGTVNGRKSIVEEDLIRFDDEPNVIPSLQEEKIEKEVKGNKIDLETLIGTNPLISDEKMQEILKEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI02</accession>
    <name>A0A0N5CI02_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pseudouridylate synthase 1 homolog</fullName>
            <ecNumber evidence="12">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA pseudouridine synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Forms a complex with RARG and the SRA1 RNA in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI02"/>
    <dbReference type="STRING" id="174720.A0A0N5CI02"/>
    <dbReference type="WBParaSite" id="SPAL_0001746400.1">
        <property type="protein sequence ID" value="SPAL_0001746400.1"/>
        <property type="gene ID" value="SPAL_0001746400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="21">
        <location>
            <begin position="202"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001746400.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51960" checksum="3A84AC86A354EE38" modified="2015-12-09" version="1">MPSHTKETPRVEDELHKIISGRVEKSSKETNDANKTPREKQDRKPVVRKYAMLLAYQGKNYFGMQIQKDQSTIEGMIFNALEKCGFITEEQKNDPYSFYFQRAARTDKAVSAVRQTCSMFLPRDLNVNIDGHLKMNDNLPPDIRILGFRVATRNFHCQKDCSSRTYSYTVPSYTFAPLDELTKGDYRISEERIKEVNDVLSIYKGTHNFFNYTSRRDSGDKSCFRFIIDFYAGKPFIYKDSLHEKEHEFITIFIHGQSFMLHQIRKMIGMSIAVLRGHTFKSEIQRSFEPIRMDVPKAPGLGLVLEKVHYTNYDKKWGKSHPTLDDWGEEVEKSIESVKIDLVYKEILDTECYKFNMMQWLADISKHSFSENPTSEEGVNRELTGVQMANSLLKNIQQETEAKTVESNVQVKEETSLKEEISGKEEIPVKEEILNKDEMSVKVETNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIA0</accession>
    <name>A0A0N5CIA0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIA0"/>
    <dbReference type="WBParaSite" id="SPAL_0001755700.1">
        <property type="protein sequence ID" value="SPAL_0001755700.1"/>
        <property type="gene ID" value="SPAL_0001755700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001755700.1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5053" checksum="C17A6A947F365F21" modified="2015-12-09" version="1">MLEEHQTVEVHRTIISSQIRVAEDIQMEEGDDDGDNAIEEIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Q6</accession>
    <name>A0A0N5B1Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ING domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0000001100.1">
        <property type="protein sequence ID" value="SPAL_0000001100.1"/>
        <property type="gene ID" value="SPAL_0000001100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000001100.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31674" checksum="0197CAF7C17162D0" modified="2015-12-09" version="1">MDELDMLIALEKKIQEDLLIVNEVVDEILAMQHELDEKYEEVYRLLNERIQYKDMFHNNCRNMDALVNRTLDIIDHSQDETSFYNDTSSDNKVLQDEPSEILFDDDIVSNDKSLQDVEDDIVLNDNNVRSEADVSENNDKIVGKKDKILQASDDEVTNRIDAKKDETTQVDGSEFINKIDDEKDETLQAGDGKVTNRIDVKKDKTTQVDDSEFTVKIDDKKNDILQAIDGDVINKIDGENDKKQQVDNSKNMEEKIYNTPGKIRNLFSLKDYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2E1</accession>
    <name>A0A0N5B2E1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2E1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2E1"/>
    <dbReference type="WBParaSite" id="SPAL_0000024800.1">
        <property type="protein sequence ID" value="SPAL_0000024800.1"/>
        <property type="gene ID" value="SPAL_0000024800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000024800.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="72659" checksum="0927DCFE53B20CEC" modified="2015-12-09" version="1">MNGREIGNFINFVSPLDHDNGGRRSRNPFESNNIPLNDKNIFDSSEKYEQVSKETDNSIIEVTSDYFNNQFAIFSKLREDGHFCDFVIKCANISFSVHRIVICGLSEFFKAMLTNNMVSNCNTNSISLSYICPETMESIINFAYTGKIKISERNVEDIASAASYLQIPILLDHCVNYMTRRIKYSNAVKIYKFIKSIRGDTDRGSMRYIEKHFLQLSRTTDFLQLDYDEFFEILKSDHLLVDSELQVLEVILSWISHDIPYRLQYITKLYKTIRLGLVSIEMINDKFKIHPVVPGALKKYLSNEEANNIFDLFRKAEHQFMDYANRGRHCQDVSPIIYAFGEINKDRNNISGVGSVIECYDKDSDKWFRNDSTILQRKLFAVVYDGNSIIVLGGNDGSNKLKSASRYDRFTLDWKSLPPMLSRRSALCAATINGVIYAIGGYDGSAFLNSMEFFNPQTLKWHHGPSMTMQRSGAAVVVYQDLIIVIGGRCGQTVHNSIEIFCTRRFQWKLITNALQVPRFGHTASLYNKQIFIFGGNNGNETLKSCECFFIEHERSYEFPSLQYPRANASSHLVNNSLYVFGGYNDERKLGSTEIFSFKTNQWNFGPFLRFIEGSVQSVIINTNTSQILNKDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2L6</accession>
    <name>A0A0N5B2L6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2L6"/>
    <dbReference type="WBParaSite" id="SPAL_0000032200.1">
        <property type="protein sequence ID" value="SPAL_0000032200.1"/>
        <property type="gene ID" value="SPAL_0000032200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000032200.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8714" checksum="E0F51C31445DD656" modified="2015-12-09" version="1">MINDYVNPNVIIMTTHLALAGKIDKYEMTGFDYIFMDDASYISTTTALIILSKFPNSKVCYLGDSQQLPPLRLHNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B313</accession>
    <name>A0A0N5B313_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B313"/>
    <dbReference type="WBParaSite" id="SPAL_0000046400.1">
        <property type="protein sequence ID" value="SPAL_0000046400.1"/>
        <property type="gene ID" value="SPAL_0000046400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000046400.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35737" checksum="B514D423DE930AFD" modified="2015-12-09" version="1">MEDVVNSPVHCNQFTSFLKLGQIDRGSKLDICVTFATNDKCSNKKVKLFEFKKNLKISIKGQEEATKVAHQKITINNKQNLDEVGICKEESIVIEKQGTLTVELVLNIFPDKEHVEENISEPINKDDKCSSPKNINPQSLSQTSGNASLSSSKITDKMEAPKVATEEFMLESYNSRVNESCGSVDIFQAIGDGDRTASKVTDNDITKDDGVLWQSGGNVLDSHNSDGTTVANESEISKTLPAVSNDMEVCNAETTKEVHVSNIGHMADINVSNVSTKQFERDCISEHSSHINKDNTTQSFLNRSGTYPLSSQKPNIAIKFLSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3J0</accession>
    <name>A0A0N5B3J0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5B3J0"/>
    <dbReference type="WBParaSite" id="SPAL_0000064300.1">
        <property type="protein sequence ID" value="SPAL_0000064300.1"/>
        <property type="gene ID" value="SPAL_0000064300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="493"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="2202"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1599"/>
            <end position="1618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000064300.1"/>
        </source>
    </evidence>
    <sequence length="2309" mass="264853" checksum="A37043C251E4EB0D" modified="2015-12-09" version="1">MTYQYTLAVNPYSHLDKGKRFSTFLTQLKDTMTIDCIVDQDIKFPLLRSRLADHTMEIIPDVLPDETFEQYTTRLSTIFDDNHLTANLETQYSFYKLNFTSDKFEDSLREFHRLHEMMYKNLPTDVNFKAFRRKLLDLLTSRKDLFMTALKSTATTNQTILLELLQFHSANQLLTRNNKPRDICSWCSIPGHKESECRRKSNGFAKGNYHFLKNNKKDSPSITPSLKKEMNNSKKKDDVIHPLIIKEVKVNNHPMRALIDPGSNITCISPDVRDIIIPPNSPETFHQISSNGHRHFATSTLCPVTIQIEDHSYTLENIYINPVPYENYNILIGMDYLKPMGAIIHTSDGSIDFETTPETIQKKNHSYTLGNIFINPLPYENYNILIGMDYLKPIGAIIHTSDGSIDFETTPETIQVNNAKLGSIITEVEFERKIKHDIQNNFPSLSPSNEYDVGPGKLTAPEQIIFPTQDIPDFKYYHTPQTPELKSIINNLYENGIIEYSDAIETCPYYLLTKRLPDGQQQLNDDGSPRRRFVLDARRINAATHKIVQQSPHLTTIIGSMYPFKHATKLDLTNSFFQITLHPNNRHHFSFTAFSKTYQFCRLVQGAKNSSSIFQRSIEKIIPSIKDAQIFVYIDDLLILTNSTPQSHYDAVMSVITCLHSYGLKINISKCEFYRESITYLGWTFKGETFGPAADSVSSLLKKSRPRTKKQLYARLQSINYFRMMSPLFTKYSRNLHSIATNKSSNQTIEWTSALIDDYNKLIDCVFATPLHLPPKDQPYILKIKVDACQTGIGSSLIYVLSSTDIPKPIAHYSYKLPESKYGRSPTYLELLGIKKSLDFFHYFIINADSTIIVESDHKPLQYIHKSNEKHLLDLIQCICAYDIKITYINQSSNELADCISRLFTNSVQLKKRGRPRKIQFDHGKNMDEFDSMDIHVLQLQNSDNSILDALENNTPWEGTFLKRRGDDVIATTQHQIAIPENLETINKILYLAHDKSGHYGIDRTLQFITNSVFIPHIRKYVVNYINNCTICQSTNSAPSLLPDKESNYTYFHPWENVSCDILGPLEETSRLNKHIILFVDIITKYLIAKPIMNTQSATIEKIILQVIQVHGPMKVLRMDNAPYFKGIVKFLESYGISPSFSTPLNSTGNTFAERHIQSLQNTLTKELLVQKDKEWDQLTDLVAYYHNISSKPDVPSPFELHFSRLSISPLSMRLKTTSYLGKEMVNVNHSPTTYYKKKLTRKLQPKYSVPCSLKSISKDGNQLPDIQQISDSQLLKYSDILNKKPKDQLQILKLCITRDIALRISPISISPIFSPHRSSFQFDSEQTLNLSISDVEARELIHNFSQTFPSPSHSSVSSQEILYSANSSPTQPLLAIEYKQKKMTYQYTLAVNPYSHLDKGRRFSTFLTQLDDAMTIDGIVDQDIKFPLLRSRLADHTMEIIPDVLPDETFEQYTTRLSTIFDDNHLTANLETQYSFYKLNFTSDKFEDSLREFHRLHEMMYKSLPTDVNFKAFRRKLLDLLTSRKDLFMTALKSTATTNQTILLELLQFHSANQLLTRNNKPRNICSWCSIPGHKESECRRKSNGFAKGNYHILKNNKKDSPSITPSLKKEMNNSKKKRRCNTSSYHKRSKGSNTTCISLDVRDIIIPPNSPKTFHQISSNGHRYFATSTLCLVTIQIENHSYTLENIYINPLPYENYNILIGMDYLKPIGAIIHTSDGSIDFESTPDTIQVNIAKLGSIITEVEFERKIKHDIQNNFPSLSPSNEYDVGPGKLTAPEQIIFPTQDIPDFKYYHTPQTPELKSIINNLYENGITEYSDAIETRPYYLLTKRLSDGQQQLNDDGSPRRRFVLDACRINAATHKIVQQSPHLTTIIGSMYPFKHATKNLHSIATNKSSNQTVEWTSALIDDYNKLIDCVFATPLHLPPKDQSYILKIKVDACQTGIGSSLIYVVSSTDIPKPIAHYSDKLPESKYGRSPTYIELLGIKKSLDFFHYFIINANSTIIIESDHKTLQYIHKSNEKHLLDLIQCICGYNIKIIYVNQSSNELADCISRLFTNSIQLKKRGRPRKIQFYHGKNMDEFDSMDIHALQLQNSDNSILDALKNNTPWEGTFLQRRGDDVIVTTQHQIVIPENLETINKILYLAHDKSGHYGIDRTLQFITNSAFIPHIRKYVINYISNCTICQSANSAPSLLPDKESIYIYFYPWENVSFDILGPLEKTSRLNKHISLFVDIITKYLITKPIINTQSATIKKIILPVIQVHEPMKVLRMDNVPYFKGIVKFLESYGIFPSFSTPLNSTVNTFAERHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3J6</accession>
    <name>A0A0N5B3J6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3J6"/>
    <dbReference type="WBParaSite" id="SPAL_0000065000.1">
        <property type="protein sequence ID" value="SPAL_0000065000.1"/>
        <property type="gene ID" value="SPAL_0000065000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893935" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000065000.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13915" checksum="E2352470FF66B359" modified="2015-12-09" version="1">MNSLSIAILFGILINISCGFLTNCTRNLEKPCTAWLKPGEPAYKKFLGCLKDPEKIGIGLALGENDPSKIKKENELIESKVPTESIKCFFSKLKNRPYAPNRKIVIVPYDSRMSSRLNKQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5E3</accession>
    <name>A0A0N5B5E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5E3"/>
    <dbReference type="STRING" id="174720.A0A0N5B5E3"/>
    <dbReference type="WBParaSite" id="SPAL_0000128600.1">
        <property type="protein sequence ID" value="SPAL_0000128600.1"/>
        <property type="gene ID" value="SPAL_0000128600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000128600.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56453" checksum="612318A73300F47E" modified="2015-12-09" version="1">MFDEKNVKMQKSIWNLIFDEKKFDKNEINSKNKPRLIHVIIVIFLEYFSWGLVTIPAINFIGRNYPEDKFLINGLSSGGRGLLAFIFAPILGKLTDMYGRKKFLFLTVLATCLPIPFLLHDSQWYVTIFVVTGLIANSFAVANAYAADITNFSDRHTAYSVISSTFGASFMFSPFLGAGIANTYGDNVAIIIATGIVFFNLFYITFIFPESLPRNIIKSENYNDETFWLIINEFFSLRKMWADEYTFKISMIIFLSNVPEAGQISCFFIFLRAIVGMSQNEVGSFIAYIGLLTVFSQLFVFKYLINSVGIKGTLAFGLMTQCIQLFFYGFCTNIYLIYIFGLFLAFSQVVYPSIASAISLSYSNEEQGSAQALINGLRGLCSGLGPVLFGFIFQLFNFDVHSDLDSSININGAIFPPPNIKVNPLAIHVLTPNKTSTSDEKESEFLRVMPGPPFAMGSVLVFIAFFFLLSVKKIKGKNRKRHGSISEVTINGGSLLLSEHMDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5X3</accession>
    <name>A0A0N5B5X3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5X3"/>
    <dbReference type="WBParaSite" id="SPAL_0000146500.1">
        <property type="protein sequence ID" value="SPAL_0000146500.1"/>
        <property type="gene ID" value="SPAL_0000146500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000146500.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16559" checksum="BAE31D2CF6093B19" modified="2015-12-09" version="1">MHFWLSSPKNCSCRSTCEELENNTCKHIGAKIHIAEKEKNTLALAELKGKCVFFIKSNNNNGNITIDINYIEFGGSRTPNKNSFIEIKYRNDKGTKGLTIYENVSNVELPSLSDKVYIITNDANGSFDLEIEYHLNITETDELKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5X7</accession>
    <name>A0A0N5B5X7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidored_molyb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5X7"/>
    <dbReference type="WBParaSite" id="SPAL_0000146900.1">
        <property type="protein sequence ID" value="SPAL_0000146900.1"/>
        <property type="gene ID" value="SPAL_0000146900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000146900.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15254" checksum="A9083F0108F09410" modified="2015-12-09" version="1">MFENREKDPLSSLRRGSGQYGSISSIRSGGRWGIRESIRGSMRLQPKLVGAVGNLLCNGFPAKSVRIALYYKNNMKVKTYLDGIYSNERGAFMVRGKINPILRVHPIAQWSSGMILALGARGPGFDHRLSPAFCFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6K8</accession>
    <name>A0A0N5B6K8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6K8"/>
    <dbReference type="WBParaSite" id="SPAL_0000169600.1">
        <property type="protein sequence ID" value="SPAL_0000169600.1"/>
        <property type="gene ID" value="SPAL_0000169600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894020" evidence="1">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000169600.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="27631" checksum="C6936ADF07845461" modified="2015-12-09" version="1">MILTLFLLNIYFLFVMAGETNNMIYYNNRNVNKKFYRKSNSPSSSILYTSRFQLKNRNNNAINQPVKKQSYTKTKQNFRYYAIATQPVSKKAPLQTLPNIKYTYTKHVPYQYYYKNTNVGPTLPYKYNINSNYARPYQYNYYQRSPYYTPYYYNYYSRPQTPQYNYYSTPQTSQYNYYSTPQTSQYNYAPKPSPLLSALQQEYTYPHKGHGFFGNELAQFWIVCHDCPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Z0</accession>
    <name>A0A0N5B6Z0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Z0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6Z0"/>
    <dbReference type="WBParaSite" id="SPAL_0000182700.1">
        <property type="protein sequence ID" value="SPAL_0000182700.1"/>
        <property type="gene ID" value="SPAL_0000182700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042308">
        <property type="term" value="P:negative regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000391">
        <property type="entry name" value="Large tumor suppressor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WARTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="604"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="19">
        <location>
            <begin position="914"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="226"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="417"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000182700.1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127999" checksum="2A6134F09A1F3CE2" modified="2015-12-09" version="1">MFNHRYQYGPSGQTGVPGLHSQGTFSNNGKTFDGSQIPNNTSIPQHIITTKNGTSTYCIDTSDSSNVQNGKHYKEKLSCIREDLKAFEQQSNYPVNNHTTYQSPVKNIPFSGYTSRSPSTNQRLSPPSSYTDSNNGPSPNNSNRDSKQKSMVNYLTSMGYNKVDAICALNLVKYSSVTAAANLLISIEKNKNNDGIIGNGNGVYSNKVNNNIHTSIINVPSNGKVYSTQQSSNVQQGPSSTSIPSSTTTTPTTPPSSTTTTTTTTTYPVNSIEENGNCDGYQEYNKRIPLHYQQYQNNYYYNECLEKQVGSGGYVNDMTKQTPQRTGTVISIEQNNGNNNPPTNNTSNNNVSLTNYKTSINTNDIRKVPSSRVPGTIQDNMNQKSNYNNIEVKRSDSYKIPTTNNARNINLIKMHQQTSFGNGGTPSNLPKQQSLTTTPSSGSANRNSPSLMNNIVNNNRGIQSIIVNPDAPPDLGKELDKICKVVTRLPLINSTSLDIPPTVTIDDSNYYNNKNEERRKSSGLFEKNIGKRKVVRSLSPLPESVGVRLKNNAFESNIRAIQLMSEMEQAELPERLKEQLLKFLSQKESKYLRLRRQRMNVGMFDILKHIGVGAFGKVSLVKKKDTGQVYAMKTLVKTEVIQKQQAAHVKAERDILAEANSPWIVRLFFSFQDSCNLYFIMEYVPGGDMMQLLINKGIFNESLARFYVAELTCAIEYVHNLGFIHRDIKPDNILIDKLGHIKLTDFGLCTGLRWTHDKRHYVIAENENGEIPEHMRSDSLTFPVNGNNCKEPVKVLEQRYAKKRNQAHSVVGTSNYMAPEVILKIGHTKACDWWSVGVILYEMVLGRPPFMSQTEDPRETQYKIVNWKHYLNLVDHTGKLSRECLNMIKNLCRDQETRLGKNGANEIKKDPWFNGIDFNTLRSRKAEWIPKVDHAEDTSNFDDIKFEDDIFGGDLPPQFVNNPAFYEFTYRHFFDLEGQGPLTGVKSHHPHKRAPLSNIEGMSSIKTINENSNDKGALNVIKEGQKISSNFTRTTTSFSPGKESPITSNIIIGTENQGKIVNNITNVLQQQQKMVNGGMLTGNMPNGNRLNGFHLLKHHQKYKLSSAIRTPSMGRKGNQLEGGRNGVIVEDESYESDPSELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B729</accession>
    <name>A0A0N5B729_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B729"/>
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        <property type="protein sequence ID" value="SPAL_0000185700.1"/>
        <property type="gene ID" value="SPAL_0000185700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cystatin_sf"/>
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    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894051" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185700.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15339" checksum="492E45A3A4644744" modified="2015-12-09" version="1">MDYFKLVVFVAVTVLLNIEASYVKDYYALGNGWKYKDTKRPTIVKLAGESVNAFNQEHGTNYKLENVDSARKRREREPHYKLSILAKTNCGKLNTPCTKHLLSDVYGNPKSGNKLKISVEEDQNYYPYHLNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7B2</accession>
    <name>A0A0N5B7B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7B2"/>
    <dbReference type="STRING" id="174720.A0A0N5B7B2"/>
    <dbReference type="WBParaSite" id="SPAL_0000193800.1">
        <property type="protein sequence ID" value="SPAL_0000193800.1"/>
        <property type="gene ID" value="SPAL_0000193800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893999" evidence="1">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000193800.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31884" checksum="2A36CF2A95E9D8CE" modified="2015-12-09" version="1">MKFLNFLFIIYKILLFKSSIQWPTTNEYKFQLTSTSDVIIPVLDGFSGRLQCTVYRCKDQALSVSWLKNGVVMFNNTKFIVSSGVDPSSVYLQHTIDEESMKVEDCKEMFKLPQGKTCNCITENYNLILRNITKQDGGDYRCVINEVPQQLDFHVEVLNSGLKQGFHKHIRYDYTACCLERGINPMCRSMCKPRDMYLEVFDPISCQSADFRNFIHCVTDDGRKNYTSCCQARNIPDFCHDFCSNNFTMLKKSHRLCLYYLPEIFECFNLQADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7B7</accession>
    <name>A0A0N5B7B7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Cysteine dioxygenase</fullName>
            <ecNumber evidence="3 11">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="11">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7B7"/>
    <dbReference type="STRING" id="174720.A0A0N5B7B7"/>
    <dbReference type="WBParaSite" id="SPAL_0000194300.1">
        <property type="protein sequence ID" value="SPAL_0000194300.1"/>
        <property type="gene ID" value="SPAL_0000194300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00012">
        <property type="reaction ID" value="UER00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042412">
        <property type="term" value="P:taurine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="9">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000194300.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22792" checksum="EF96EEB28CD2ADAF" modified="2015-12-09" version="1">MDEMLKKMRAEFDKDQYSIDSIRKILASYKSRKEDWEKFYFYDPHKYTRNLVDTGNGKYNAMILVWPEGIASPIHDHTENDCFVKVLGGELTETRYKWPKAQNDEEEMIEIGKDTYSINEVTYMCDEIGLHRMENLSNSKPAVTLHVYIPGYKTCQIFDEHTGHKTKCHVTYYTKFGQKVNYKGCKEGTIVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S4</accession>
    <name>A0A0N5B8S4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S4"/>
    <dbReference type="WBParaSite" id="SPAL_0000244700.2">
        <property type="protein sequence ID" value="SPAL_0000244700.2"/>
        <property type="gene ID" value="SPAL_0000244700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244700.2"/>
        </source>
    </evidence>
    <sequence length="537" mass="64384" checksum="AF3838BEFD5D3D72" modified="2015-12-09" version="1">MDNKKELTFLDIMNCDLVRKTILEKFSCVSDITNLAKTCQEMNYHLLGDKIKLKMYIYQDFQNVNVKDIHRSIENPDIITFENMIFEKDLRCYTEFDNVKKLNCEVFLKNHCINIFYKNWVEHFLNRERMLLVKKLWNNMNLECEVRKNMKVLDFLINFSYNHHLVLYVLSQVKHNNIVRIKIPDITFMAYDTSVYEELPSNIFDGFKRFSELEVNCLYFQYNYDGLVKNKHIFENILRELSKRENATLILTFSRCDYIHITKLTKMILEITSKYKIKVNCNVRYILNLWSKKSNIISSNNISSYLPIKDYITTIIISISNSKVLLKIMKILQCLTNLKSLELEILFYNIRKNLKNVDKININDLSLRNCIKLERVKFNFPDYTNRNENVNVKKFCRNFKYLVSLMPKTIKRVELIKIPIITKNLAISIDENMPNMEVLMMDEVLIKEPDSIVPFNKLQTLICYKYIPIQIPPNIEVVAIKLNHSNCNETQLYNEIIQNYSQKFRKILQNTKDQRYIFFNNLKKWDIYKDMIEELFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA47</accession>
    <name>A0A0N5BA47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA47"/>
    <dbReference type="STRING" id="174720.A0A0N5BA47"/>
    <dbReference type="WBParaSite" id="SPAL_0000291600.1">
        <property type="protein sequence ID" value="SPAL_0000291600.1"/>
        <property type="gene ID" value="SPAL_0000291600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF27">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR NPR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000291600.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42504" checksum="F78B5721BDE87DFB" modified="2015-12-09" version="1">MELIYSLNSNCTPYIEAYPDPSNSWISIIGFGIYYSIIFILGIIGNLYIIILTLKYKCLQSVQNLFILNLAVADIFLCLISIPITPYVNIYKEWIFGSPACLISGGIQGISIFVSTYSLCAISIDRYYRLIESPNIILKKVHSIFATLTIWILSFILTLPYIYNMKLVSYDDICGYFCTEDWGNAKHRQIYTIILLFVQSVIPFCIMAICYQQIFATLHNRTNSKVLSITQQINLLSMITNTVGGNNVPIDKVQVNKLIEKKKKIVQQKKKITIILVLMVLIFATASLPLNIVSILTEMDSLSIFELKDGTDLTYIINISVHAIAMIVCITNPLLYALLNPEFRFLVMKSINCQTSVFNLGGNSMYYSTQECDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAD4</accession>
    <name>A0A0N5BAD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAD4"/>
    <dbReference type="STRING" id="174720.A0A0N5BAD4"/>
    <dbReference type="WBParaSite" id="SPAL_0000300400.1">
        <property type="protein sequence ID" value="SPAL_0000300400.1"/>
        <property type="gene ID" value="SPAL_0000300400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001072">
        <property type="entry name" value="Transcription factor unc-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="10">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000300400.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="75815" checksum="4E0534D60CD16DF4" modified="2015-12-09" version="1">MFPGRHPVSNGNMPPNNFQVPNPGGFKSSIPEYLDRIKEEFNQMNNQLQQLRVELDKVSQEKDTLQRHYMMYFEMSTNVSMEMHKQMEINKRLSAILNSVIPLLPTDHQSSALTASERAKQISASEIQQIMNSTLHQQQMGMMGNMGMLGNPAAIAAMAASGPGGMNQAAMAAYAAAAAANMNPALNINLLKQSMSPAITTPNNLSSLGNNETRSQSRTKSKSPSMEPSSSKKQRLEDSEGDLEIDVSNDDNSNPQSGLNSSNGIKQEGRESVHSNLSSDSKNALKQFNANNTATTDMDAMASQLLSNPNLASFAAGRSNLNILDPTLQAHMMALTGRGPNVKPSYSFKTDSNGSYQPVNFPPDAFTGPGIPSTFTVAHTLNHGEVVCAVTIDNQNKNVYTGGKGCVKIWDITTKTDGVKTPLHTLDCLKDNYIRSCKLFSDGSTLIVGGEASKITIWDLEAQKIKCELDSNSQACYALAISKDNKYCYSCNADGKIHVWNIDSQELIATLPGHQEGASCVDLSFDGYTLWTGGLDSTVKSWDLRENSQLELFEFGHQIFSLGCSPTDDWVAVGMENSTIEVLNHVNRSKYTLHMHDSCVLSLKFASTGKYFISTGKDNVLNCWRAPYGANIFQLKENSSVLSCDISADDNNKKCRFLNFKIYFLLHIIYIILFKTVIHLYLKCIRGETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB72</accession>
    <name>A0A0N5BB72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCDC158</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB72"/>
    <dbReference type="STRING" id="174720.A0A0N5BB72"/>
    <dbReference type="WBParaSite" id="SPAL_0000328200.1">
        <property type="protein sequence ID" value="SPAL_0000328200.1"/>
        <property type="gene ID" value="SPAL_0000328200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000328200.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22167" checksum="2AA08DF33E0A20C4" modified="2015-12-09" version="1">MSTPARKEGAKRGSKRNARSTSVATNGSTDLLVESLCTHTSPIKRARVQEEYELGDLNNRLVDCINIVKRLENDKSQLEIKIQGIENKISRSEAGFNEKTSQLDDLKSKAEIGKQLQRTDKLQASRQGIDNMYRSQLNEANVAVKHARENSAKATEKAARLKIRLPELSANIHFVSLEIASVITDDLSNQQDLNASHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBH9</accession>
    <name>A0A0N5BBH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000338800.1">
        <property type="protein sequence ID" value="SPAL_0000338800.1"/>
        <property type="gene ID" value="SPAL_0000338800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000338800.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8437" checksum="33F7D0A3CE8B120C" modified="2015-12-09" version="1">MKVAPTISGNLERLTEDRVNLDEYLKELLNKPLIFTIKVSKFISPSQPDKPSSNKLIDYINFCPAQVYFSWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD99</accession>
    <name>A0A0N5BD99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD99"/>
    <dbReference type="WBParaSite" id="SPAL_0000398800.1">
        <property type="protein sequence ID" value="SPAL_0000398800.1"/>
        <property type="gene ID" value="SPAL_0000398800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894198" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000398800.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25007" checksum="5A923A9E55C73DE3" modified="2015-12-09" version="1">MRIFSTVFTIILISNIVKSYNSRKNFIIGATPLCQDPFGMQESYNIRIPTEDKVTMFLFLSTELKEEVQRDSEKQNNYPGFLTKTGFCNQKIKITDSLSDEILKLHGRKSTDLNSTEYHVGFFYESKYPGMVKKIPDDCEDPGKVTVDEILCDFGELDPNKVRTISENTYQYRLLLHMYSHLLNRDSYYPKGPDRSKTQIEPNFEKYKERFKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE77</accession>
    <name>A0A0N5BE77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid-sensing ion channel 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE77"/>
    <dbReference type="STRING" id="174720.A0A0N5BE77"/>
    <dbReference type="WBParaSite" id="SPAL_0000430100.1">
        <property type="protein sequence ID" value="SPAL_0000430100.1"/>
        <property type="gene ID" value="SPAL_0000430100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000430100.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="65983" checksum="408475DA31870D7B" modified="2015-12-09" version="1">MKIFSKFSKKNEDKKDDDNLSIKSPSIPKRIFLMCRDFSQWSTLSGFNHIFGSKNILIILFWILVTGTCVYFSYIQTKELLDEYFKYPYNTDILLKYEEVTFPAVTICSKSPYDDNKKNNYLTKIVDAFKRKNDNNWSLYGLNNGINLSHKETIKFWLTIYGDELLNDNNINYQWKDSIISCHYNQDRCDDNNFKLVKIPSYGTCFTLNHLGTWKVARSGSEYGLKLILKIDKDDVLPFDTSYGVVAFVHSYDEYPFVEMNPILLSLGFDVSLGLSFSSSERLPKPHGTCIPNDSNELEDTDNFYGGMYQNEKCIRSCIQRKIIENCKCYYEGYAINDEYSNIKSCSTYIEEDQSRRPATLACIRTHIYPEFNGDDMTFKVNVTSDCVCYDTCDKIFYDYSYSLARYPAANFNPNECRNSVLENKRENNIKLPYSYTQNECFKYYMKNTLRLEVYFEKLSYIVSSEFAEYPTLNLLYDIVGILGFWIGISLISFFEIFVFIGVLTFAFCFLCKEPIKPIKTREIRKNIGDGWKDDIDKGRKFPKRKDLYDKAAEADKMPPIHESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEL1</accession>
    <name>A0A0N5BEL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000443600.1">
        <property type="protein sequence ID" value="SPAL_0000443600.1"/>
        <property type="gene ID" value="SPAL_0000443600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000443600.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11285" checksum="83790CB3DD2067C0" modified="2015-12-09" version="1">MYSPKQTILAKDIKEDPIKDDFYDDFKDDFYDSINESGISIEEVEETIENTRKRKLDYSPITDQSMDIKKPLLEINNDPIEDDFYVDYDDVDFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEN9</accession>
    <name>A0A0N5BEN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BEN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000446400.1">
        <property type="protein sequence ID" value="SPAL_0000446400.1"/>
        <property type="gene ID" value="SPAL_0000446400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="752"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000446400.1"/>
        </source>
    </evidence>
    <sequence length="1128" mass="130211" checksum="F44B190C6577454F" modified="2015-12-09" version="1">XKKKTENDGRKTELLTKQIKFQSVSNTCEATISIAQCKLDGLEESIDFGMDSCASYCTIQTEIFNKFSPELKEQYKNNRNEDVLLTSIHETTSITNSYINTYITISGCPKIIEKKKIRLFIDPKSKLPLISFNFMCDNDIDQRWFRKENDCSNKSNKNLIGKYGITYWKFSKKFKEFLDEDKSRILWDPSMIVENKITVELKVNDEYSPRRMHIIPVPINLQKEVKEILDNEVSRGWLTKLKDNEKVNNTNSLIVVKRAGKSLRLCYSMLHVNKFIENSIIESLPSAKDLLLESNIELISLFDIRSAYRSISLSNKSKEFCIIATQWGLYRSNSLTFGCKASPSLFYNEIRKILKGLECYVKVYVDDIINHAPRNIHEDINIEICRRLRSYNFRLATDECYINVTSGIFLGMNFDVKKGLSIPAERLEAILNLPSPSNNKEIKSIIAKLRFYGDNIPEFPLYAQNIYKIIDKKPFDKERVNLEFKSLLEKTAKAITLECIDKCCISITIVVAAKDESLAYIILCNYESIKKPIMVGGRQLRTHEKNYKEGTKIILALRKAIYKKSNGIISLTAFNTHQRLLVELSPFQIKFQFTDTNKDLVSEFCNTKFSRSTTVIEESYEAIEIAELLPFSSSELKESYKNDKAANLILDMLLDVKTKEEIKMKLASSFIKFLDTIELVNEIIFINKKLFITRELSSKLMLFLHKEHDNAYAMQLKANKYYIVAVNNCLAKEIYESCNICNNLRRNKTRTVDSWPSTDSSHERFHEDVGEINKTKFLCITDVHSGFIMIETLKTEKSLEIINKYRSIFRLYGKPTLLVSDNTRYFCADETIQFLESINVCPIFAIPRCPQSNEYGEKTTEAVEKAAIVLQDRITKNDKTAKEIFFGIDINIKDVLEKHNFKPKPMSVECLFKVDRSDKQWRAEIAIEQVGRNIFRIGSQDRIFIRKLSSINFTKEGRTVNIDKIWCKDNEVMSNKSTEMPINCMSNNVDESCQVRESLERNDTLNNFNESLQFSKTLEKDDLLGLTHTIEQENLDLNQYCMETEEEYQQFMKNGEFRIECGIDGSAYQGVGSAFVLKSSYYNINTVSEMKGNSSDSAQQAEMTALILALEEIHLLAYSKTILKMNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BER2</accession>
    <name>A0A0N5BER2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BER2"/>
    <dbReference type="WBParaSite" id="SPAL_0000448500.1">
        <property type="protein sequence ID" value="SPAL_0000448500.1"/>
        <property type="gene ID" value="SPAL_0000448500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000448500.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21481" checksum="62BAE2C412A5AA89" modified="2015-12-09" version="1">MYRLDTPVFPLRANKRRSHFFRIEHENFDDHFKDFIKNIVAACSIRMATLLTNTEVDGVNESTRDLQRSEKALQTLVKIEFLYALPTSIGQELENKVRILTILELKDKAAELVLREKDKRAVREKWHDNDRKPKSTRFYKSSKPAKINTVQPQESFEPMGEGPSGVSIEDQHLDFRKPILTRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BET2</accession>
    <name>A0A0N5BET2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMRFamide neuropeptide</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BET2"/>
    <dbReference type="WBParaSite" id="SPAL_0000450400.1">
        <property type="protein sequence ID" value="SPAL_0000450400.1"/>
        <property type="gene ID" value="SPAL_0000450400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894259" evidence="2">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000450400.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14886" checksum="92C71078316D5F17" modified="2015-12-09" version="1">MKYFFLTIFLTIVIFGTNFTKGSSSENTTDENIVYIEKRFADSIKRRVARALTKDRVSPIDDSESSRNFMRGPRDRRRPGNKRFDREYGFGSDKMFGGLPPKSDESYYDSENSADDESVSDYYYRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEY9</accession>
    <name>A0A0N5BEY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BEY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000455900.1">
        <property type="protein sequence ID" value="SPAL_0000455900.1"/>
        <property type="gene ID" value="SPAL_0000455900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000455900.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44210" checksum="F47886980D4AA486" modified="2015-12-09" version="1">MNGFNNKSLLLKKWGKNIEGSLEFYDSFNGFIIIIGFLPIVTRKIQILEVIDASSGTVCHKSSFCPGDCSSISINKYRTDGILEIAIGDCSSISINKYRTDGVLEIAIGKKNGEIEIMKGRWKTSNFNIFNVEKYDFGEKVTSICYISKDNLVFSKCGYLYVFDGKDRCKWSNNGKIKFRNAIYDIQKFKDDAVLGIVHGKILVFFRNKKPYEIFNDNNCKVINFWIDHSTSMLSISCAKKLGNGRSNKTPLAYILCEITRKSSSSSNDEEDQKYFASTVKNIPYDGRRFPINHRPTIFSMIKGVKSSMYTLLPDFESKKIGACCILDGDNILGDVDFEELKKCVGTICVNEAQKFLPNVFKRRIIVLFKYQFDVIDLYCSIPGDQKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEZ2</accession>
    <name>A0A0N5BEZ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box/LRR-repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEZ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000456200.1">
        <property type="protein sequence ID" value="SPAL_0000456200.1"/>
        <property type="gene ID" value="SPAL_0000456200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000456200.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19471" checksum="5289759F9586AB41" modified="2015-12-09" version="1">MTFYSVQDENLGIIPHYYKVTVLLFVPVVDSLDIFDILNRSSQIGAHIRCLKISNLAEKDFESFIIFIEKFSSVEVLYIEHICSISTEIKNVYFLLSLSSLNNIRSFAISEFRETKILSADMIIKLIEKNSEIRSMYIGSWNIYFFESLFKKYLTIEQPCKMECKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFL1</accession>
    <name>A0A0N5BFL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FRA10AC1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFL1"/>
    <dbReference type="STRING" id="174720.A0A0N5BFL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000477700.1">
        <property type="protein sequence ID" value="SPAL_0000477700.1"/>
        <property type="gene ID" value="SPAL_0000477700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000477700.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="31185" checksum="42E727F14B5D68E0" modified="2015-12-09" version="1">MGKTREKKEKRKFEKILKDMDIFKRHQKLISTFVDMKQKEAGDVDGISKNRASDIVKNHMKFIYDTNVDENRMTWEEKLAKRYYDRIYKEFCIADLSKYKENKIALRWRLEMEVKKGKGQFICGGKDCEIIENLSTWEVNFKYKDEDEIKNALVKVRLCEECSKKLNFHSVKKKINKIYKEVKKKKEISNKKVDESRDCEESDKHIKEDTNKCTITTVQEISTGSQCVDKSANSSSLTKDLEYKGENTNCVEELDTFLDNYLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG16</accession>
    <name>A0A0N5BG16_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM and PDZ domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG16"/>
    <dbReference type="STRING" id="174720.A0A0N5BG16"/>
    <dbReference type="WBParaSite" id="SPAL_0000492400.1">
        <property type="protein sequence ID" value="SPAL_0000492400.1"/>
        <property type="gene ID" value="SPAL_0000492400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF3">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="248"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000492400.1"/>
        </source>
    </evidence>
    <sequence length="925" mass="105075" checksum="B39B51E44BE861A0" modified="2015-12-09" version="1">MDNKDDYYSDNAKDKPNQCDMCVLEDQRLFYIDHISKSVTYNDPRQGASSDSSGYFEIPNTQLSLKETSSGEHSVSGSYILNSDIDISESSTEPPSARTNEERTMKKACSTKLSQNEQPNEDDKCLHEKCVDEERRQVNLIKDPDIGFGFVATSQMPVLVQYVTPNGPSDGKLCVNDQICMVNGTNVYYMDKEEVINMIREQTNEITLTVQQLPKKKKRNKKDFHVRFTDKIHVSNMKTSDFFDEIPDVIRVYLENGQTKSFKFDDTTTVQDIVNNICSKLLIKQINRFVLSLENSLSLRASKLVILKPSLKIVDLSNSAYVTYTRCRFRIAFMPQDIASFQISDSSAFDYLYYQCINDVVGGRFSLEMRYESCMRLAALQLRQLAYDNGNLIGNHVSINCMEKEYGLATFLPMILLENVKIKRIKKHLRLYLKKDEGNKRDGRNLSLVKKCIQSELGSEEFIENTEPIYSLIENTNDIGKVCKLKYVEIVSLLQSFGGKTYNVTFKQTKVDMVIQINHFQGLLIRQQGIHSQPTISVSYDLIEKITIVDETEIIKLILIELRNNCHPGLDFLIDKDYAEDLVYYIIGYAKVLLSKDIPCTYEKYVPSSVLVNYGPPQFRSIHIVTPSDWNYSSEVDPSTKMMVNLINDPPDYEQAIKATTAYYNETNEKKICSNNIVEDSNLKVDNEVKSANIENVTVEILQASNESLDNCKEEETKTSRFNLKFNDSIRLHKKRHSIVSSQINLSASNTSLNAFDNEDRRSSTISFNINNISLLKSHLSNQNAISSSSHMSGTSINEEHNNSQKLRASPAKSAKNNGITTVRRTSIHPLSNINDKEVTNSDIVNSKITSNKNQEEEEDAEKNNVTDFDSTFSKKISSSDSSTINKIPNNLPIQLFNSQEQDHETEIIDLTNGITVSKTIQTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGN4</accession>
    <name>A0A0N5BGN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGN4"/>
    <dbReference type="STRING" id="174720.A0A0N5BGN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000513400.1">
        <property type="protein sequence ID" value="SPAL_0000513400.1"/>
        <property type="gene ID" value="SPAL_0000513400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000513400.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62260" checksum="085EA4709E400E4C" modified="2015-12-09" version="1">MSNTTDPPILNDSQINPETPTNGNLTTQNHPPTQPNGIDMGQLQNVINEMIRNAINNYLPAVLPQVNQPTCVTQPPPQVIQPPFNQPTCVTQSPPQVIQPPCVTNVIPTNQFENIVTENVNDEMPIVNNREDLDMLNVHRNRMIYSNDRHSFVMPEKFNVKDNFEFLKPSDSRERKNEMKIKYLSKVLPSAIQGNYFCKPMNTLDDGLAAAKTLWFQEQRAKRDKARGHSILKFYNHRSDNRNVKPYQHQKSHQNNLYCSYCKMNNHSTATCRNSKNKLKAQSNNIEVNDPQSNNIEIVTKDVKTDLINKDEMKNDVINNEVCDNYEVQKVETIDESPPLPRNHSFRDILRKINVKDNLIGAVVKLNGLNVIALIDTCSNCVIINNKLKDKLGLTTVEERNISTFQSDNTALKISTPITIQIQKEKFIINDNVYAAKDDFKNDSYDAIIGTNVLKRMMAVIDLQTGKIIVNEKPKDLVKDDNNISNVILSDQDVNINIDKFVTDLKLKYPLAYARHSLDIEPGKIMVNEIIVYNNKEMIKAPYYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIB2</accession>
    <name>A0A0N5BIB2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIB2"/>
    <dbReference type="STRING" id="174720.A0A0N5BIB2"/>
    <dbReference type="WBParaSite" id="SPAL_0000569600.1">
        <property type="protein sequence ID" value="SPAL_0000569600.1"/>
        <property type="gene ID" value="SPAL_0000569600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000569600.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35062" checksum="0D848930B0ADDAF8" modified="2015-12-09" version="1">MSLHSFSRYQIVPIVTKYVQDKKGTNISRIDMLNLQNTKPETLKKELEELFNGLGHERILLPSSIEVPDDTTIEFNYKNILGCVDVGTIISTDYTYGLPEKAVAYISFKLIDAIEYLAGKRIVHRSIMCPNILINKNGIVKLVGFHTAVSLNTKKHWIRKSDNINEYDPDILKDCLNYLAPEVLKQDLVGYHCSSDIYSLGVTICTMINGFTPFSDMPELEMLYEKYCGTRPKIIDSSSTVDDDDEGIFDKYKEKVLSKEIHDVVVETLDCNPETRITLKKLKQHPFFIVNGTSKEILSYDKLFNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIY3</accession>
    <name>A0A0N5BIY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000591200.1">
        <property type="protein sequence ID" value="SPAL_0000591200.1"/>
        <property type="gene ID" value="SPAL_0000591200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054291">
        <property type="entry name" value="DUF7027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22954">
        <property type="entry name" value="DUF7027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7027" evidence="2">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000591200.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26153" checksum="90222647F6AB84E2" modified="2015-12-09" version="1">MDFSPTADKWKCCCCLLPQGLQILALIEIIIFFSLLIGTLIFTVTSQPSTLQDIIFNYSFIFVLAFFTLSSILLIIGLRKIIPTLLYPTILARILLIIFLQIFGVSKTLLTDEALNEDEEMEYNSRNEYYHNRGNYKNSKQYAAVRFVGFVFLFIFITIALIYTIYIVVRALKYVNGYSKLLIRRSSLVAAEVISDNMIAQHYRIESLINESHKEQGNNGSGEQLHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJE5</accession>
    <name>A0A0N5BJE5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000607100.1">
        <property type="protein sequence ID" value="SPAL_0000607100.1"/>
        <property type="gene ID" value="SPAL_0000607100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733417" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="37"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000607100.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="47206" checksum="0BE2B6125DF7EFEF" modified="2015-12-09" version="1">MVILSYTFILIFFCAVTNSIKAPNFNDDTNIYRQKRAVLRDLTYKWNESIIYYKVDTNISKDNIAVALEEIMEETCLRFQEVSLSTRNRSITGFYFQLGYMDATNLGRKLDNGNFQNLWLTSKYPERHKVLRVVLYALGVDYEYNRPDSEKYVWTLWTSIQKRYMPYMFKKNNKTVTTYDLPFDFKSVMALNQYEYSNKPGFKPFVMVKEEDRKKNLDTVNENLSTNDIKLLNLHYCGGKCIKMSVCQNGGELDIGGCSKCKCPPKYTGRYCQRLKSVDHKICGPADILIDSKTEEEKELKFSDKCGYSFRAHRGKVVEMKVEFTKKRNISEYLCTENAAVELKFERDKIRSGLVACDIIDTVLTYSEDELFFLNFYGTKNDKVKISYREIIPLNIYGFFNKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJK9</accession>
    <name>A0A0N5BJK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Envelope-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000613400.1">
        <property type="protein sequence ID" value="SPAL_0000613400.1"/>
        <property type="gene ID" value="SPAL_0000613400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000613400.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13383" checksum="B5A41CB6B0EF3CB0" modified="2015-12-09" version="1">XSQKIHFLAKPLLSISRAILGCLLKINCQDNIDVEVELVDPTYETQTIFNAMCRGAHPSGITIAGEGKFNFTRIINMIHTEKLKMSLSNSTLFTQEEKDKVKYRVEVVNLNSFVWVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJY5</accession>
    <name>A0A0N5BJY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DC_STAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJY5"/>
    <dbReference type="STRING" id="174720.A0A0N5BJY5"/>
    <dbReference type="WBParaSite" id="SPAL_0000625200.1">
        <property type="protein sequence ID" value="SPAL_0000625200.1"/>
        <property type="gene ID" value="SPAL_0000625200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="7">
        <location>
            <begin position="436"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000625200.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="89629" checksum="9B2EAF93DA104E87" modified="2015-12-09" version="1">MSYIELIRARRRVQKSLHQFVVYEENARRKYNGINEFIPEHSKFKTFLRTVFPFIRSEKDYKAETFYQRIYEEGTRENSVAKILLSFTILQFIGFLMYSITTFKYAVFPQKAGVYIGIIVQVIICFNIFSKFSRCVIMLSFPALITSKLRQILLLLLILWAFQNSAMNVTKNFQQTAEGISCVQNRIISVVKEVMGSINSVLGEKMIEDVIELVRQILNPMELFKKNVGGLSNMITKMIELFGDESSILRKAQDLCDESLVGPEAKCRRFVDESIESCEKRVWKIFCLPIKTLYASCNLVSAMVAHCNMPSKIIQYVNSGVNNMIASAANQTINSLKKNGKLNVFGGMSDDAIKSLSKGHLIKDFGLEFVADYDSHHKNDVDLTKLKELIKKEFEFLVKLLYYVETFINSAIYFVVFEGILWSTIYLYKFLKREKHDNHYIGQRFIEMDVQREIQGMSCILPLLDREKITYIKSYQKKLTKLEKRWTYFRMSLTFFSGVVPFLLVAMDIVVYNSFEMLFHFLTDDVFFEFPSLYKFKVSGNGMFAGLLNKILDIFEPISSLTKKKDNMWTQCLVEPSPPNYELYEKMLYVFIFCFILCPAESYLKRFRHVIASSYYPSRIQPRLLYLYNEILEKRRSSIQRAMMATKQMDEQMKLIKDHRGKGKKKNLVNKALPSLTKDTYCCTKCSRGDLRISDEFNTRICVNCHSVYCIDCYTIRKRCIDCNYTLQVMTHQIEFYYDSSGDESDSSSSSSSSSSTSSGSLSPISPKGKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK53</accession>
    <name>A0A0N5BK53_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK53"/>
    <dbReference type="STRING" id="174720.A0A0N5BK53"/>
    <dbReference type="WBParaSite" id="SPAL_0000631800.2">
        <property type="protein sequence ID" value="SPAL_0000631800.2"/>
        <property type="gene ID" value="SPAL_0000631800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF2">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894715" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="662"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000631800.2"/>
        </source>
    </evidence>
    <sequence length="792" mass="90472" checksum="07F9FCEA4655797C" modified="2015-12-09" version="1">MNLSIHLFIACLLILIQCATCIVDKEQMKKTVHEMFLHGYTSYLKFAKYDDELMPLSCKGRRRGVTPSRGNVDDALGNFSLTLVDSLDTLIVLKEFDEFEKAVRFVIDNVQFDSDLDVSVFETNIRMVGGLISAHLMANILRNHDSNRLTWYKGELLDMAEKLGKKLLPAFNTTTGIPFSRVNLKYGITEKIRNQKNTCTACSGTMILEFAALSRLTGNPIFEEKAKKSMDFLWSQRHKESDLMGTVLNIHSGDWIRRESGIGAGIDSYYEYCLKAYILLGDDVYLHRFNKHYKAIMKYLNKKGLFINVQMDKPNVASRSFMDSLLAFWPGLQVLKGDIKPAIEMHEMLYLVMKKHKLIPEAFTYDFQVHWGQHLLRPEFIESTYFLYKATKDEHYLEVAADVVKSLNDHVKVKCGFAAIKDVRTMTHEDQMESFLLAETFKYLYMIFAEPEDLIFDPDVFVLTTEAHFLPLSIGESGTDKPRKIFLDIDEVVDEDHHKYDKICPYYEEEFKNSEKIVEYGKSIRLETQAFVKQLTSGSSLKDETCEVIQPQLDPKNFKYDDKEQLKLLNDIGITVELDKSGNIKFTHTPFTAQCAARAKQGLAYMTEMINIHKTLSEANENLMMKLTRTVQIISAPYYGLKYKTIASPAQYGFDFSDPKFVTGKLELAKPLDGCSPLYNIEDCNGKIIIMRRGRCMFQEKSRNAQNVNGIGLIIIDNVVGSSTETAPPFAMVGDTTQEDDIYIPTVLLYDVESQDLLKAFQQNPDIIVRIGESFANPSQVFQKSLISYVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKF1</accession>
    <name>A0A0N5BKF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000640850.1">
        <property type="protein sequence ID" value="SPAL_0000640850.1"/>
        <property type="gene ID" value="SPAL_0000640850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000640850.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8783" checksum="8DAA9D3AE3F644E7" modified="2015-12-09" version="1">LSQHILHSSDHMKNFHVLYSSCIIIVCFKLKLKKYVHQLLWIPLQYLNEYLNGKTKNFVYYTSNISFFKMKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL09</accession>
    <name>A0A0N5BL09_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL09"/>
    <dbReference type="STRING" id="174720.A0A0N5BL09"/>
    <dbReference type="WBParaSite" id="SPAL_0000661200.1">
        <property type="protein sequence ID" value="SPAL_0000661200.1"/>
        <property type="gene ID" value="SPAL_0000661200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000661200.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60558" checksum="88BDC76FD7863C38" modified="2015-12-09" version="1">MSDCNNIKLQQIIPSECDMLLEESHMDESDKIRNNSQGNLPIDIVVETITAAVNLPDSDEEDEVITIKALNYQLGKKGFKVTEQENGADLEITTKLDETDNNDDGGRKKKSIVMFKKGHRRAWSMPYNNKEKNIVAVVNNDEYAIDDKNKKHIIRYRLHPKKEDGSKQNMNSSIELKNVPVLKDLDVPPTENLVEELNVDLDENEVLCYTEEEVGKTKTRTVIRKLWEPKWTTQNFELLPEWLQDNEYLKTGHRPPLSSFSACLKSIFTLHTETGNIWTHMYGCVIFIGISLWFLTRPETVVPPMEKFVFSAFFLGAITCLGLSFTFHTVACHSDAVGKLFSKLDYTGISLLIIGSFVPWIYYSFYCRKLPTIVYISMITILGISAIIVSLWDKFAEPAFRSIRAGVFVAMGLSSVFPVIHLLITDGFWRLVNGSSFQWLILMGFFYLLGATLYATRTPERFFPGKCDIWFQSHQLFHLFVNVAAFVHFYGIIRTASHFLEEGSCREQLMEQFGPSYEINSVDRFFGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLE4</accession>
    <name>A0A0N5BLE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLE4"/>
    <dbReference type="STRING" id="174720.A0A0N5BLE4"/>
    <dbReference type="WBParaSite" id="SPAL_0000674200.1">
        <property type="protein sequence ID" value="SPAL_0000674200.1"/>
        <property type="gene ID" value="SPAL_0000674200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000674200.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="73078" checksum="DFB06E88E37B3641" modified="2015-12-09" version="1">MSNNIYSAYLHSNGIYLINSTDISSNCIFETHDLWSKNIFKWIKPNKKYNNCKNTIENNYYNLKNGILSLHQKIPNDTKCTYKCYYPINDKKMREGSVNNLIEPVNLDCDTLEINCKNKKNKTTFVDLGFHINNFPKLEKKNFNFLNSKYKMKKNIKKFNVFIYVVDSLSYYQALRGLNYTRKILLNDFQGIEMKYLNIQGENSRPNAYGLLMNKQRDDIYDSYGVRPVIKNDFFPKESCNTPLDNNTYIVDYYRQMGYLTMNAEDFFDSGVFNYYNCIGFTENPYHHSLRPFQILKTKKRNEFKQLEKEKCYSDGLFLLDYFDQFLEKNTSMPKLSLVWHSFLMHDDINRIFSADEIFQNFFKKNAKQINNSFTILMGDHGFRLSDYQKTDIGFYEHKNPYFIMTVPYELRSNKHLINNLKTNSEKHISHLDIYATLLDILTEATNNNFTNLQPYDLSNVVNEKIKGKSLIRPLEHRSRDCYEMYIPIQYCLCHVDFKYLELKNKKEYEMLEKTFIKELNNKIVIGNLTNICAKMVLDKEEKFIVKKATDGTRGALYQIEATTSPGKATYRATFNDKMVLIGNEITRTNSYNKQAEVCEKKSEYRKFCYCKSLLKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLE9</accession>
    <name>A0A0N5BLE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000674700.1">
        <property type="protein sequence ID" value="SPAL_0000674700.1"/>
        <property type="gene ID" value="SPAL_0000674700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894691" evidence="6">
        <location>
            <begin position="25"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="71"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000674700.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40422" checksum="9643F308A059E06C" modified="2015-12-09" version="1">MKIFFLCLAVLLFIAQNSIEQSSGANTLSLRKPPYYKDLLTSTPYYWDKSLEKITNPKISIRNRLYNVTDDIYFTFQLINQETCLNFEKKDNPITNSIGINFYLSSDGKNVVTLSNNPKSPTNVSLQESVYKNATSLAFYIGLALGLIPEVARPDRNIDVKVDMNNVQDDYKKYYKIALPGVVPYLKDTDFDFKSAMFFGSDFGLSNGKQSTYIVDLYKDYQYPSTVSKSFSHNDYKHMYYYYCDGSKKQNNCKYGGYPFPKDQRYCKCPYYLDGNKCENFIFRNNLIHTFAERITKKSLVASDTEECVIVNLTDELLYLNVTSKNNKKNVSIVVEELTFERNDCKIDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLI7</accession>
    <name>A0A0N5BLI7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLI7"/>
    <dbReference type="STRING" id="174720.A0A0N5BLI7"/>
    <dbReference type="WBParaSite" id="SPAL_0000678300.1">
        <property type="protein sequence ID" value="SPAL_0000678300.1"/>
        <property type="gene ID" value="SPAL_0000678300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="190"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000678300.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="78843" checksum="550FA4E5E33A9C1F" modified="2015-12-09" version="1">MLPSKLDELFKDDQYLLPHKNEIVRRYNAFQDGLKVIDKCGGLNEFTKGYKHYGIIVKDDNSIFCREWAPGADGLSLVGDFNDWNKESHKYTKKDFGKWELEIPPTSDGDCVIPHDSHLKIVVWKNGVPHYKLSPWATYVRQYEKEVIYHQRFWNPKEKFAFKHPHPPKPESLRIYEAHVGISSHEEKVNTYMDFADNVLPRIKKQGYNTIQLMAIMEHAYYASFGYQVTSFFAPSSRFGTPDELKYLIDKAHSMGITMLLDVVHSHASKNIDDGLNEWDCTNSCYFHGNARGYHTLWDSRLFDYTQVEVQRFLLSNLRYWIEEFGFDGFRFDGVTSMIYHNHGMNESFGGGYPMYFGMNVDTESLLYLTIANYMLHNFYPNFMITIAEEVSGMPALCREIEEGGQGFDFRLAMAIPDLWIKILKHTKDEDWKIGDIVFQLENRRYKEKHVTYAESHDQALVGDKTIAFWLMDKEMYTNMSCLTENTPIIDRGIALHKLIRLITYGLGGEAWLNFIGNEFGHPEWLDFPRAGNNSSYKYARRQWNIVDDELLRYKFLNNWDRAMNELEESFHFLTRGYAYVSWKHDGDKVVAFERAGLVWIINFHPSKSFTDYKIGVEVPGCYKIALNSDEEKFGGHNRLDMNQSILTFPEGYAGRRNHICVYIPSRVGIVLKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM77</accession>
    <name>A0A0N5BM77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BM77"/>
    <dbReference type="WBParaSite" id="SPAL_0000701800.1">
        <property type="protein sequence ID" value="SPAL_0000701800.1"/>
        <property type="gene ID" value="SPAL_0000701800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002542">
        <property type="entry name" value="T20D4.11-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431:SF5">
        <property type="entry name" value="PROTEIN CBG06905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431">
        <property type="entry name" value="PROTEIN CBG06927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01579">
        <property type="entry name" value="DUF19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894605" evidence="4">
        <location>
            <begin position="25"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="T20D4.11-like" evidence="5">
        <location>
            <begin position="742"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="T20D4.11-like" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000701800.1"/>
        </source>
    </evidence>
    <sequence length="1495" mass="165458" checksum="890F975329C97504" modified="2015-12-09" version="1">MVPSLRYLIIVLISIYLFISIIKSAPTTFPTCSPEEFQCNDGGCIPLDSFGNGKKECADGSDEQSEETGSQPAPPPEEIPNNPLPENPVQENEKVPQHNIEDPFENIPTSEPIPETPNVDPPKSKTLNKKKCSDDGKSRRKECTSNLKLWYEDVESVNFLNISILNDFNSIDLLQQGCEMLSQYRNCMGEFVGECVLPKKLKEWSDLEMYACQLLLPAAREHGTGCFSIVRNSQCPTDNVISTLTSPFCRLVRATAGDLDCIESSKTDEKCSEMAVELLGPLKSETDHMMMESLICETIEDAHNRGDKNDDEYDDNSVPTTDNETTDTTQESKIETVDKLEDNEDKNSNAPTSLTTQKTALEESKIDDDEPLLSSVNILDSLAFFTNLEEICSEDKKDDIFLPLKSIVCQNKSKLKQHSECFVKAKGIVNCPVKSPLDVTTKCAVIETFNSNIDCIITTLNEECTVEEQETVVKIQEKLNDDAIVLQCYKTEEATNSTENMSNDGFNLTPKNTRCTSRQENSALVCLVELVELNKQMTNFASFNFLLEVSNIDSTFVNNVCGLYDRYEKCLGETVFAQNEGKRCAFNSPLNSLARIGLSPICNSENRHKLSEARECIEIIGTVGHGNLTCKDNGLQNMGNAVQMMLQGIHGEALLCKVFYSIRSTFECGEALIKEKCSPDAYKKLSELKVDFDNIGIEEGCPPEMPGDLDEIIAKPVKPTLLQPITPKDPKHSKSAIVSPVCTPEEQRKFQICVQNLTSYQPHPLAVIKIPRQIDEACLTYKDFKDCSKNVKCNPLWAQGMSAMFEYACGKGYDQYQNIKSCIRKTTTRNDIRECVTNFSKGAPSEACSSSRTLLECSVDIIGDKCGETAKTWVKEYVQKFASAIDSSCQIEGPSITTTIQAINCSPVEKQMIYTCAAPLNDISSRIDELFEGGLQTFMKNVNNLAPVFAQGCNLTAEFRSCIAPIYATPTECIASSCLIRAGNGICDKEDVPAAIDENLNCVFSNAADPNFAKCLRSGIASIKDFNMNTLRAILPKFVECVEPMVLKKCGPVPLNVLKSFGTTDVCPVELLPTNVEKTDKPIVPLTGSICDSETATKYDTCKKDFYRNYRFVPIQLIPNVNDTTKMCQEALQLSQCVEIENVGVCETKSHKALKNLIVSICKHGNIFQNHSSCLANVVSSDEGAKCLEAFMNVQPNSDEDLCKVIKDSSQCLSKPVYENCGPEAVNFAYDTINSYTQNLDETCHITSPSISLQTGCSEEDLIAYLQCEAIIDRYHYIPIAVLPDNTKMGEFCNSARDVYKTCLNNLKCKFEPATTASLSLFDDLCGTFKEEQIKHGDCIASIFNSFEGKNCLQPITALDVLSKEGYKDICHGMTSAFECAAPLIEDKCKYEAVLHSASLYENYLRKFDNKCTLENIKATRNFKPMDSNVTTTEVTTEKSTTNPVTETTITEDSLTTASLTTTTVTKSKENCASINSSLSLALFSVIISAIILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN88</accession>
    <name>A0A0N5BN88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN88"/>
    <dbReference type="WBParaSite" id="SPAL_0000736700.2">
        <property type="protein sequence ID" value="SPAL_0000736700.2"/>
        <property type="gene ID" value="SPAL_0000736700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37433:SF6">
        <property type="entry name" value="ACTIVIN_RECP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37433">
        <property type="entry name" value="PROTEIN CBG25136-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894653" evidence="2">
        <location>
            <begin position="34"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000736700.2"/>
        </source>
    </evidence>
    <sequence length="358" mass="40749" checksum="1BFBD0D805BAEBE7" modified="2015-12-09" version="1">MKINFSFISIYFFKKLIFLFLISILIINLPVNGNQCYSCSGLCHNEKCNCQMGSCESDYCYIERRPVDIPGIFRITKGCVKKPSRTQAGCDYDTLPDHIYCVCSGHFCNEAVHMKQMIRKNVTCRKCSEKDPNCDNVCVGHWCHEDSLTGVSGCGYGPPSLPYFYKGPHLLFHRNRICVTIARGPLAKPRKHCICNSNMCNDFMRTYHLTYNYNTQNVKSKFQNGQVSRSLFNNYPLYQCVLCEVTSHEPKMTSNCKQNRCIGNFCTYGIHRIISHDGNALSGTIQRITERQGCINVTDHSQIQLGCHDKYTSVEQKIACACASDLCNIDVVIANVTLTKYCFSYFSIILLIIIYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNA7</accession>
    <name>A0A0N5BNA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNA7"/>
    <dbReference type="STRING" id="174720.A0A0N5BNA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000738600.1">
        <property type="protein sequence ID" value="SPAL_0000738600.1"/>
        <property type="gene ID" value="SPAL_0000738600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="191"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000738600.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54761" checksum="54AFC85DD6FBFE7B" modified="2015-12-09" version="1">MTVVGAIGSFSINNSPNTILNNTTYCEVCGDYSDGYHYKIQACRSCTAFMRRCVTFNRVYSCRFSNNCKIDFRNRNTCKGCRYNKCLSKGMDTSLVQPKREPTGAQPYRRRRDPKPFKNDDGRFVNLSSDQYNNSLLSSNPLLSNRLDILSAEPSPSSYKTNQNSITLPNISNISFVNSHTISEVSLTTPGEIFLSSMSRESCQKYMLPFYNCVKKYRELQTFNSHLSVPFPHFLMDNNETPPPLRIFTPDDIDLLCRVQISNVFSWLSSISSFDNLTNSEKSDISKRFTLKKINLDTFVMTSKYPEQIDLKCIVLENYTFIPPDMTGFEKNEDTEVVRSIRLAVFRNSIDDTFETIIKPLSELKLTDYEIVALYLLLLWSKNNERFVSKDKKKLFDSQRNWVIKCLYTHYCKSSINDPEIRLGEIMLLLKELEWSYINSCKDYLMSQIFNVGILKTNWFDKFCYSEPNFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNK7</accession>
    <name>A0A0N5BNK7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNK7"/>
    <dbReference type="WBParaSite" id="SPAL_0000748500.1">
        <property type="protein sequence ID" value="SPAL_0000748500.1"/>
        <property type="gene ID" value="SPAL_0000748500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000748500.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19734" checksum="3CB691B7E5671B99" modified="2015-12-09" version="1">MAPFLSLHKITQNPVTLTTVTSGLNKTIGMGNSQNVKKSQISPKPIILSKYNNNIFNNDKSTDINLSNISGIRTYNFTSSPKISKKSVKIFHKKVSEIQKIATSKPPNLEEVKFLQEDWESFNLDSSGKKDASIFILKTKPVDNTDFIPFDINRFLTDRIAEELDIDPKVLHYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNV4</accession>
    <name>A0A0N5BNV4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNV4"/>
    <dbReference type="STRING" id="174720.A0A0N5BNV4"/>
    <dbReference type="WBParaSite" id="SPAL_0000758200.1">
        <property type="protein sequence ID" value="SPAL_0000758200.1"/>
        <property type="gene ID" value="SPAL_0000758200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase associated" evidence="1">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000758200.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36944" checksum="1F2FAE826B778602" modified="2015-12-09" version="1">MSLKELSALDNDGNLTAIGFQMTNFSFDPAHTKSLLISVLFNVSEEMTLFMAYDSLPTPFFSKKAPKDRITAVINNHYLKQFPLLSDHFMAWNFHNLAFSDNITVSEYENECTNFCINTSSSSLLFKINRQINRKLRDSFELNNIIVDDSMEASEKYKEFILCSLLVKTHYPKIGYLIQSQSTPDKSPIVLNDFEGNAIKIQSDSCLYSGITSNWKQALDSSTPFFLYSKKREAKDRVIGTNLTNVTPLQLLLFGCKNAYTDKDIGVELDQKMLININRKVASHILGLRIVIDNLLDSLCCNGKLTSSEEEIRRKLVKLIAKISAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPG8</accession>
    <name>A0A0N5BPG8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPG8"/>
    <dbReference type="STRING" id="174720.A0A0N5BPG8"/>
    <dbReference type="WBParaSite" id="SPAL_0000779300.1">
        <property type="protein sequence ID" value="SPAL_0000779300.1"/>
        <property type="gene ID" value="SPAL_0000779300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040271">
        <property type="entry name" value="T19C3.2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443">
        <property type="entry name" value="PROTEIN CBG09852-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37443:SF2">
        <property type="entry name" value="PROTEIN CBG15264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894736" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000779300.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25193" checksum="251DD736BD4833B4" modified="2015-12-09" version="1">MFLPILFVIFSLLGKCVDCQISAMFGNPIQAENCQEWSEWNPCIWLHSQNRTNKRFDRSYFDQLLPGRKGCRSHVFFKILRERFGTAFDNFYNYLRKMTISEKQCGECSYQQSCGRNCHRRGNGNIINPLFVAERKCADIDQSDACVSRQLNGGCKLWPNPAIPLPNVTSSMVDIINGLDYLTCIPEKRINGDVCRCCCHPYSVNPNTFKCELKSYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPW1</accession>
    <name>A0A0N5BPW1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000793600.1">
        <property type="protein sequence ID" value="SPAL_0000793600.1"/>
        <property type="gene ID" value="SPAL_0000793600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014:SF1">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000793600.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10942" checksum="347412E9E81C9C27" modified="2015-12-09" version="1">XMSTYKCTTAYSYITSNYNCLTTADHLSKDAITKCFSNMLTSSEDKMCEAGNTLIQCLDAIYSSYCGPKAADFVCNVAKIDMTYDIPQCADKIMKCNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQT4</accession>
    <name>A0A0N5BQT4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQT4"/>
    <dbReference type="STRING" id="174720.A0A0N5BQT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000824600.1">
        <property type="protein sequence ID" value="SPAL_0000824600.1"/>
        <property type="gene ID" value="SPAL_0000824600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000824600.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26191" checksum="038EE88958A33140" modified="2015-12-09" version="1">MLRCKGFVTTKDGIAQCAPYIVAPTSTTTTTTPPAASTAKADIYLIRDVSESVLNKVYASTLTDFLMEFFNNFKIDPKYVNVAFSPSPGDDNIWFTLPVSNEFYGNTSLQISINSSYYSLDGVQSPGQKQLSEIIGMATNLRFLNTGYNPSYKPHWLIYVTTISSPNSDAIAAAQKVRKSGKFKVVTIAYQPVYNIQALLNMSDCFYSAYEPRHLSRIAKGLATIISYDSSKGQDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRI9</accession>
    <name>A0A0N5BRI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000848800.1">
        <property type="protein sequence ID" value="SPAL_0000848800.1"/>
        <property type="gene ID" value="SPAL_0000848800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000848800.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22330" checksum="BC4B5D87175C2FE8" modified="2015-12-09" version="1">MSSLIRIKKRSRLPWNTNLSSNSSFTNQNTISKDTSSRSSNNNHLRTSDFSKLSKISAMTPPSYSVYENSEGEMINEKENVKWPERPLTGYHSLKEYKKRKAFIRKNIRDQEKYGKNKDKDHSSSTSALDLKQNEGSETSKKFQASCVTTGKCANMGFCNMPNINANEENSGKIDYINGSNVKQSYLFCGVKTPQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSD7</accession>
    <name>A0A0N5BSD7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine-rich PDZ-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSD7"/>
    <dbReference type="STRING" id="174720.A0A0N5BSD7"/>
    <dbReference type="WBParaSite" id="SPAL_0000878000.1">
        <property type="protein sequence ID" value="SPAL_0000878000.1"/>
        <property type="gene ID" value="SPAL_0000878000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000878000.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7772" checksum="E0BBC2E68F3E98AE" modified="2015-12-09" version="1">MTGTERKVFQKYYPPDFDGSKVPKIRTKKSSYFIQCVMTPFNMQCNTCNEYIYNGKKFNMCCNICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSG3</accession>
    <name>A0A0N5BSG3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSG3"/>
    <dbReference type="WBParaSite" id="SPAL_0000880600.1">
        <property type="protein sequence ID" value="SPAL_0000880600.1"/>
        <property type="gene ID" value="SPAL_0000880600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000880600.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12721" checksum="6E5042D82F53DD7F" modified="2015-12-09" version="1">MNDNINQEDYSFELDFFASKCQIIAQKFVTNMMGFEERGCFTKLSEIYKKKTNEIEECYQDVKNISIILCHYVPIYELVSETSNQIQYLLNTGRIEGDGNLLEYRDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTC0</accession>
    <name>A0A0N5BTC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000910600.1">
        <property type="protein sequence ID" value="SPAL_0000910600.1"/>
        <property type="gene ID" value="SPAL_0000910600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895132" evidence="2">
        <location>
            <begin position="25"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000910600.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="68214" checksum="8F15D804C77B3071" modified="2015-12-09" version="1">MKALLNILPSLLLFFCNLLIYTNASDENYALTYQYEIIETGTLSPEYQASRENRSAPVSIYVSENETKEKQLLVFKISLDIKNLPQLRVYHKMIFNIKYNDQELENIWIPNNETNRNFKLPNIPDDFHCNLMKCRIGFSSINNVETSMHNHGDVLPNDFIYISLEIANNKNRFQLGTITVPTYIHNLYAVICPSKNWVSEYGLLKYNPNNHFMIHFPDGITDSFDRHIKLMNPWNRGEDNFCLCGHLEQNFGPSLDIGYNYYQYYASEPTLFVDEYSLVFENNTLICEEWDIFSKNVVAFIISIPQYNFQSNRTTVHQLTKNSKFYSGEIIAIMVLEEMKGWYEENDGFNDKFEIQTYCNVPNFNANLRLRINDTLQLLTTIDDEIYGEIDSFTIDYKTIKNDIPADCILEHDKQVFPQFQDLYVKRFKTSLQIYDEDDKKYYDVEALKLLESNKKYKCSLIVPPNHPDVEELDFIKEYEFIVIGNKDLYNHTLQNSTENFTNDTNGNNLTNSTNNRSENTTKNIKLVIYISIGIFGCLIIIAVTGISIWIIKNKERSEKCKSKIRKLLPNSWKKRANRSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTP8</accession>
    <name>A0A0N5BTP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major sperm protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTP8"/>
    <dbReference type="STRING" id="174720.A0A0N5BTP8"/>
    <dbReference type="WBParaSite" id="SPAL_0000922500.1">
        <property type="protein sequence ID" value="SPAL_0000922500.1"/>
        <property type="gene ID" value="SPAL_0000922500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894996" evidence="1">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="2">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000922500.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21491" checksum="90456258F3A8C020" modified="2015-12-09" version="1">MFLKLYWLGAAVALMPLLIQPNEVHRMELFPYVPEDINNTTFPFDLNVTTNSDMVLVKCPDTDYRHKNNNEMFGRNSKIFNPKGIFSPNASLFAWVPLLKTESGPTKLTCGEIVLKDNANPYHEWTFNVMWKNGTGDGKFIKRVRSIKDIPPDHENCDFLDGNYKVFGSKKKGDFLLVEKFQNIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUU9</accession>
    <name>A0A0N5BUU9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BUU9"/>
    <dbReference type="WBParaSite" id="SPAL_0000961700.1">
        <property type="protein sequence ID" value="SPAL_0000961700.1"/>
        <property type="gene ID" value="SPAL_0000961700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="514"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000961700.1"/>
        </source>
    </evidence>
    <sequence length="670" mass="77179" checksum="2F138D702F2D5DCD" modified="2015-12-09" version="1">XNEDCTVADEMNNGNNNCFKAEKGYKSTLVAYYNLNKNDINARKYLYNEIPEYYWFDLKTREWKLRHRQRRTIGRIFTVSPMNVELFSLRQLLLHVPGATCEGDLKIVNGFQWPSFRDAAIARGLLDTEDNYNELFEEACESAMPNMLRNYFGLMICYWPSFTRHYDTFIKFKNYLIEDYLMKYNGNEERAEAQAIFDIRNVLQSNNFNGYTDLPEVNFDIIEIDYVEDKDVLKRLGEENLKSANEEQRNFINRILNIIVNNFSDKRCFFLEGPAGTGKTFVYTTLYYLIRAEDKIVLNCASTGIAATLLRNGQTVHSMFSVPITLFDSNFRLSKLNKLRTTMLEKASLIIIDEAPMLSKYVIDYLDQQLKKVCKNDLPFGGKVIICGGDFRQTLPILPNSTRHQNVLFSIKYSPLWNVHFETVKLTRNMRVKEDEIDFAKWILDIVNDIFGAKNESILEKSNYAILAPTNVIVESINNEVLNTLPGDVEKIFSADSIRKDSDTDENYYIMPIEMLNQLRPSGLPPHVLNLKVNAVIIVLRNLNIKEGLCNGTRLRIIKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEYSFTLARKQFPVRLAFAMTINKSQGQTLSKVGVDLTTPVFSHGQLYVAFSRVKSPDCLFVKTESNKAKNIVYKEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVS2</accession>
    <name>A0A0N5BVS2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVS2"/>
    <dbReference type="STRING" id="174720.A0A0N5BVS2"/>
    <dbReference type="WBParaSite" id="SPAL_0000992800.1">
        <property type="protein sequence ID" value="SPAL_0000992800.1"/>
        <property type="gene ID" value="SPAL_0000992800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="466"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000992800.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77497" checksum="6DD3F6A3D5655CF1" modified="2015-12-09" version="1">MGSINSEEDRRTESFAKFELDAESLKENYRYGFGSYTPDYLQFLNNPYFLSFFMGLASFFQSIAVNGAYPMAISSLERQYNLNSKQTGTANVAYDLSVALIVFYVCKKGNTGHKGRWIAGGVLFTSIGCLLCGLPHFLYGPYQVPTVINHKNTDLGQCTFRNITITNNLNELTYFEKFIRKFKVGNIGLYLDPIFLMLFFGMFINGAGSTPLFSIGTAYLDENVSQQSSAMFLAVNAFMQALGPVFGMMGFAYLLNIYVDFDTIDHNDLNLKDSNDPRWIGAWWLSFLITATASVITAIPLFGYPTQLPGARIHRMHDIDQRHQVAKEVEDKLEYIGIISCIKSFKYIISNLPFMFIILENITESMILNGFSGFMPKIMENLLNVSPLASGFLSSSVIIAACCGVILGGAILQKLKLQLNGMLKINMTFHILAVFFMCAFIFHCPSKEFIGVNEGYHGTLVKQSKITLNDTCNANCYCKEEWNPVCHISTNKMYFSPCYAGCKENYEDDDNTILWKNCSCVDGSLNTTKIKQGFCDIECGKNRYFFILLIMGGTVCSFAAGIPAQQALLRMVPFQSRSFAIAINWVLLRLLGFLPGGYLFGAVIDGFCLKWSKTENEENKSCLIMDTHGLAMRLMQICMICKLISILGCIVAQITYKPTDRGTAITTDSEVPCSFAINDDRTNDEKLKTRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWI4</accession>
    <name>A0A0N5BWI4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWI4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWI4"/>
    <dbReference type="WBParaSite" id="SPAL_0001017900.1">
        <property type="protein sequence ID" value="SPAL_0001017900.1"/>
        <property type="gene ID" value="SPAL_0001017900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="12">
        <location>
            <begin position="44"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="43"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="314"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001017900.1"/>
        </source>
    </evidence>
    <sequence length="881" mass="101516" checksum="0F7EE6A96FEBCF1B" modified="2015-12-09" version="1">MSSNLYKSPSMANANIYKSPSVSAFAGGAAAFGNLSVADLGSLTRLEDKIRLLQEDLESERELRNRIERERADLSVQLIALTDRLEDAEGTTDSQIESNRKREAELSKLRKLLEESQIESEDAINCLRKKHQDSLLDYQDQIEQLQKKNSKIDRERQRLQHEVIELTSTIDQVQKDKHIAEKAAERFEAQANDLSNKVEDLNKHVNDLANQRQRLQAENNDLLKEVHDQKVQLDNLQHVKYQLAQQLEEARRRLEDAERERSQMQAQLHQVQLELDAVRTALDEESSARTEAEHKLSLANTEITQWKSKFDAEVALHHEEVEDLRKKMLQKQAEYEEQIELMLQKISQLEKAKSRLQSEVEVLIVDLEKAQNTIAILERAKEQLERTVNELKIRIDELTAELEAAQRELRACQAELQKMKHLYEKAVEQKEALARENKKLHDDLHEAKEALADANRKLHELDLENARLAGEIRELQTALKESDAARRDAESRAQRLQAELQQLRIEMERRLQEKEEEMEALRKNLQFEIDRLAAALADAEARMKAEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKVLQANLEDSQRQLQQTLDAYALAQRKISTLSAELEEVKNALDNAIRARKQAENDLEEANGRINDLQSINNNLTAIKNKLETELSTAQADLDEATKELHAADERCSRALADAARALEQLHEEQEHSMKIDALRKSLEEQVKQLQVQIQEAEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEVQMQVDEEHKNFVMAQDTADRLLEKLNIQKRQLGEAESITMQNLQRVRRYQRELEDAEGRADQAESSLHLLRAKSRTTVVGGKANASKVYVLEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX01</accession>
    <name>A0A0N5BX01_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX01"/>
    <dbReference type="STRING" id="174720.A0A0N5BX01"/>
    <dbReference type="WBParaSite" id="SPAL_0001033900.2">
        <property type="protein sequence ID" value="SPAL_0001033900.2"/>
        <property type="gene ID" value="SPAL_0001033900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001033900.2"/>
        </source>
    </evidence>
    <sequence length="287" mass="31704" checksum="F4914EAA1295630D" modified="2015-12-09" version="1">MFKETCFNDVTKSIDFPELNSVVEKVRKEAKMYIEDKDVLLKILYCTDLTTLSSDDTPSRVYNLVDKALNPCEKNPTAQCGAVCVYPLRVKDAKKRIDELNCNGKLHIASVAGGFPSGQYRLESRCLEIQLAVEDGADEIDTVINRGAAIDQNWELVYDELVAMKKACGKAHLKTILGTGELETLENVYKASWTAILAGSDFIKTSTGKETVNATLEVSYVMLQAISEYYKKTGIKIGFKPAGGIKTVEDACQYYLLVKTILGDSWLNGDLFRIGASSLVDNLVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX59</accession>
    <name>A0A0N5BX59_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BX59"/>
    <dbReference type="WBParaSite" id="SPAL_0001039400.2">
        <property type="protein sequence ID" value="SPAL_0001039400.2"/>
        <property type="gene ID" value="SPAL_0001039400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15574">
        <property type="entry name" value="PHD_AF10_AF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049781">
        <property type="entry name" value="AF10/AF17_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF164">
        <property type="entry name" value="ALHAMBRA, ISOFORM P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="840"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="864"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="919"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1001"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001039400.2"/>
        </source>
    </evidence>
    <sequence length="1327" mass="144396" checksum="F1C70D13D9352F33" modified="2015-12-09" version="1">MDSNKEKKSDGSPSVASLIPSGCKPKEKEMISGCCVCSEENGWTDNPLIYCDGPNCDVAVHQGCYGIIDVPEAEWFCSKCTYALRLLYTLDKEKIPSWLVNANPSTEQLLSDPKCELCPYSTGALKQTHDKKWTHVICALYIPEVRFGNVHSMEPVILKDVPFDRYSRPCYLCDDYGNKNSRDVGACMPCNKNGCRKTFHVSCAQKFGLLCEEGGQSKNVKYCGYCRSHIKKAKLDPNIKVIPAFKWGESPFTVNRDSPASNENGYLDITPSTTPVHKEKKNLHFDSENLSDDINFDHLHKTKYSSQQFPTTSSSSTKSELSAGSKKLIRNNLSTSSSTNSHSHHKMSSGSLKDYESYNLPKTIKSYDNEKKESQSFVEDQKRQNCGDEYTIEKYCTSTPTNFSSALISKANNLGSSNSIHNSIPSTTSTETSSSASSPKDSILHLQPGLELTRKKNNSIITNSVYNSPNVTPTQKELTVVTNNLDRCIPKVGFNGGSLKLPTSALSSPSSASINSDYDTRNQLIIDGTHYPSCDSEPSPVPYSYQGQTKAALKRRNYDTVFVSGNSDEKKAKIDKSEHSSLKLNSSAISPLINSNGVKHTRKSKIYKNGSSMSMTTSYSGINNRGEKESVEELEDLCKHVVEDTVSEIYRETIEKRKAAAAAAVVNTGIDTKRQSPSTTSPVPQPGNNNDYNNSKEVIKGEFAFPRERSSSVKRNSISLTTSNSSLPMSTEDKIEASISATISNNMVHENHSITHSIVTSTTSTNQPVTSTLEDLLEKQFSRGHSFLLSKAPCDVSQLLTLLQELQKENENMSQKEALLQKRLEHLTTVNNRLKMTLQQPQTSKVTVSTNTIPIEKKEENRKTPTPQYNVHIPSTSSNTQLLGGNGTPTTIINSGSPNTNSQVTIQNSDQLQSSNNGTSSSSVLSPVLSPVPRTPSSTPLSGQTQQQTYNNSTTPIHQLQQTNNLLINQNSISSTSNITNTAMTPKTSSSITSNLHLPNSSTLSQVTSSSTPSSNSSATTISTNDEIHNQIKNAALNRVIPPVATRPESRTLSNNLQNSNPLSSFNNRNSISTVETSISNPLQQLNSNTINSSTHQNLANLKIAQDIARAAAMATTSLANSNVTNNLNTTLPGTGFSKPSSTDNSPRASSTAPFSAAVTPVSNVNLQGLPTNLQSQFLMSRGSASGTPSLPNTISQLNSLNQIDTQMRDLIAAAHLAQLERNNHLQSVPQVQVSSSSQAFSEQQASLLAQLMLANQLENSAGLQSQLTNILRSQQQFQVNQLMQGYLPQNSVNMNSPNLGQSVFPTGTPPPSVSLNTSMMSSALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXJ3</accession>
    <name>A0A0N5BXJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXJ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BXJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0001051900.1">
        <property type="protein sequence ID" value="SPAL_0001051900.1"/>
        <property type="gene ID" value="SPAL_0001051900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="364"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001051900.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53601" checksum="8359748B4F710AAF" modified="2015-12-09" version="1">MNTNSENLHHFWNCVESNSAFNLSVMQNGCYSNPNHFLQSPAYGNSQRNFFDTIDIPFSSFAPINISNTATSSANNIYIQTPTSTITTIDGNKKFEHSSKNESYISGRSISKEAGESHINLSDTGELLNKNINETENCLLKTSDSQTIINKSVPIFTTSKISIPTENHNTKIQSTSSNTLTNNKLELKNSDKMFHSIETPISNFNIIHNSHFIDYSGNSSTSHYHIAQQQPIHNFSGHHKLAFNNFLTSNNMTNLYTNIPLINEQQTFSSTSQNDIYTPFASTQTNYETNSSFHVGSLPSSIPKHLPPYTTPSTTNKTDQKTFAQSSSLSIITTEELYKIKQSPHNFQNNSPSDSSTIETISPKSICSVCLNAPSNGLHFGAKACAACAAFFRRSISDNKKYICKKSQRCIITTNVETGGYRKMCRECRMKRCLSVGMQPANVQNRRQIHMVMPRKDYLDTGLFAFCYIYLIFDYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY44</accession>
    <name>A0A0N5BY44_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY44"/>
    <dbReference type="STRING" id="174720.A0A0N5BY44"/>
    <dbReference type="WBParaSite" id="SPAL_0001070500.1">
        <property type="protein sequence ID" value="SPAL_0001070500.1"/>
        <property type="gene ID" value="SPAL_0001070500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF5">
        <property type="entry name" value="EGF-LIKE CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895159" evidence="7">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="248"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="309"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001070500.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53698" checksum="AFB4AEBD6B6C6EAE" modified="2015-12-09" version="1">MKIFILLFFLLPLVNGKGHYAISKTQGNKMWNIIYRRDVDIQFEIWHDSEMEGTLISIYHQPYDHQELVFDWYLSSITNEMKVRWLVSGKNNTEDDMSTPHIREIKFPVNMVTDDWHKPMLSIRDNKMMIVDDCKIVWAMEDFDLISKKSNGIRVYIGHNIHKSNKFPGKIREFSIDHGSPISLLCPYLDTSLFTKHNDNEDEVHNEKDIDDTDNDNRINLLENEVNHIRYVVKGLVERIKKVELHQRGCSLVGGHILSFGEKHQNLENCTECQCSTSGNLQCGPIGCPKLDCKHPITVEGKCCPICGKKCWYSNIAYHDGEIFWPKNCVQCQCEDGKMNCQFKNPTSCPSLSCSEDEQITPPNECCPRCKKENWCEREHYIEKEYPCDENAICIHEDHGPKCLCKEGFFGNGTKCFDIDECHISEGQNSSCNLGTVCINIPGSYKCDCLPGFTRIDDKRCLDTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY58</accession>
    <name>A0A0N5BY58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY58"/>
    <dbReference type="STRING" id="174720.A0A0N5BY58"/>
    <dbReference type="WBParaSite" id="SPAL_0001071900.1">
        <property type="protein sequence ID" value="SPAL_0001071900.1"/>
        <property type="gene ID" value="SPAL_0001071900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001071900.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="96087" checksum="AD4AF4DDC8A02B27" modified="2016-05-11" version="2">MDKLKKFRSELASTLSYDEIKGSITNTPSDDQELLKLLNDLKDIIYANHYNELYKPNSKQLKELLKHFELLSVLLNVKEYSIRVAATKCLDSILISCSIANPQKIIYALLKEFDRNRGINSMEYILKRLIYFFKDIKLSVLQKQSKGIIDIVINLVDRKDQRIADALVIFMKTFIQYCKKCKIPDISVRYIQLAATMEEIIFENDQTTRQMLCIIENIYNEVDCIDDIIYEIIKKSIMIEEYKISEQIGIILILKHCWKKILEDDSTYVKLKYSIESIVMLLGCESNQLSLSILQFLEKLLQFPKKLKYILDVKSKENEFISEINYINDPLQNNDASEGEEWVPRKHFFFSNKISSEILVIIFDKLLSLYINNNSKNNVKIAHQIIAIGIVNEILEIVPLSIQQLSGVIDIKDIRNVTDNGLQKALLSLTLKCLYNGTNLILPNEVKMLFIKLLRDDKTTSKNVALTSLIPYTNRIIYDSQFLEEIIGCLEKSCLNENFTFQKNCIQFISSIPWQHSPEYISTTQSKNREIFAKLLLSKDKKVVMECEDNLYQFLRNGDNEINGSNVFELEVPKSLLSPYQNNFPKTMNLPKYFDFVVKPLNSSFGSNLLLLLEEVINGYHELMINNEDRLYLALLTIVRIAPISQWRDVWIPFLIGNNEPKISILSLIDEHIYNEQTQLSQLSDNIELSTYILAGLSEIDFYECFISGTKFNFDTKSTLGQMMKNEDGCGVALKTMNLYYTIITAAATNKQLIKQTIFDINYENNSVTSQTTPKINGQFQKLHDISRFLGHGIRSKLKTTFFDSQNETMLLRNFFGTYENYCTNFDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ88</accession>
    <name>A0A0N5BZ88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ88"/>
    <dbReference type="WBParaSite" id="SPAL_0001108150.1">
        <property type="protein sequence ID" value="SPAL_0001108150.1"/>
        <property type="gene ID" value="SPAL_0001108150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001108150.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18515" checksum="FC7D63C406CC136C" modified="2015-12-09" version="1">MIERQASVYFGPNFVVLVGVSYDVYRDPDSLYLAYIEHGFLDFSVFFFVFYLVTQFKSLRKQNKDFLNHAKFDLSERHHTVHNTKIARRLIPFTIILLIFCYLNEVLVFAMIFINENVELLTIINLLWLVVLSNRCLYVPIGIIYVGLCFFIPKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZM1</accession>
    <name>A0A0N5BZM1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZM1"/>
    <dbReference type="STRING" id="174720.A0A0N5BZM1"/>
    <dbReference type="WBParaSite" id="SPAL_0001121200.1">
        <property type="protein sequence ID" value="SPAL_0001121200.1"/>
        <property type="gene ID" value="SPAL_0001121200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001121200.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20827" checksum="313A6930B6A57DEB" modified="2015-12-09" version="1">MDENRKILFDDLLINAMFDKLKNMWGIKTYISKNELLKECVKDIKNTENEHVFFIGCKVYYYYNEISDNKNNFLSNALCVLLNTEKFSDCILKCGEKEFKVHKCIISCRSNILNKLLTDMKDEGISRIEINSYSEDSIRNMLSFMYTNEVASVEKNPIELLKMSHEYEIKGLKEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZN3</accession>
    <name>A0A0N5BZN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoma HMGIC fusion partner-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZN3"/>
    <dbReference type="STRING" id="174720.A0A0N5BZN3"/>
    <dbReference type="WBParaSite" id="SPAL_0001122500.1">
        <property type="protein sequence ID" value="SPAL_0001122500.1"/>
        <property type="gene ID" value="SPAL_0001122500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001122500.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25682" checksum="9C81C96B3E22274F" modified="2015-12-09" version="1">MYPSNYLDLITYSKDYNKSWRILSAVWIFLTICSTILHMLVIINPEWIGNNKTKSYFGLYNYCNNGIDCEWDIMTIKPFSIISHISFLFYVSAAILNGFSIFSIMLFVLLTERYVFLVASWFQLLSFVMTTIGSFVFPFSWDHSIAREICDSQIYTLGYCSVRWAFVMSIVLIFDQLLLSILGFILARKQPQRLPEYYDYLNYCKGSSFDGSRDEKEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0L8</accession>
    <name>A0A0N5C0L8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0L8"/>
    <dbReference type="STRING" id="174720.A0A0N5C0L8"/>
    <dbReference type="WBParaSite" id="SPAL_0001154600.1">
        <property type="protein sequence ID" value="SPAL_0001154600.1"/>
        <property type="gene ID" value="SPAL_0001154600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF105">
        <property type="entry name" value="CYCLIN-G-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="51"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="6">
        <location>
            <begin position="575"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001154600.1"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126641" checksum="9B3A9D97B3C634F9" modified="2015-12-09" version="1">MADIFKSAFDYLSTQTESIRNTVAGSSATGMHGKNNHELVGTFVEVGGLRLVIRSLLAEGGFALVFSAQDSQSNWYAVKRQLATTKEAAANILKEIRFLRQLTSHPNILNYASAAQNKNNNGSTEFLLLTELCSGGSVVDLMKKQKKLSPEQIVKIFYSTCSAIYHMHSQTPPLIHRDIKVENLLFDKDGFVKLCDFGSATNKQYNPNEDWSSLERGKIEEEMVQNTTPMYRAPEIMEMYSNYPIGVSMDVWALGCVLYYLCFNKHPFEDSSKLAIVHANYSLPAESQYTVFYSLIKACLKPNPLDRPTSDSLKESIQSLAKSMGVDLSKPVSGIENFTEHGDPVPMGPKQAGMNNETVSSQGSVLSSLKGQGLSLFKNLKEKSKDVVQTVQSTYGSKGPDVTWISSKILMAPLPENIPDALKSTFDETLKSHIYQTTQGRFLILYNLGNRTFKCDYKGKSFEAQFPPSNSGIAPSLNYLFELLTDISRYLSRDEKSVLILVGPELSCILMAAALIIFNKILPTADVSSIVRSLLRKRNSDDNEKRMPLCYMRQLEYIQTIVNCDSQQLRSLIHNRPISIVSIHFTSIPVANRAKTGSRPFIEIYSGITKLWSTFKDYTLLREYNSLTDSSITMELENLPVLNDVTIVVSHARFNRMTNKTTSVFMFSFGFYSSFHDVGQSTIEFDIKNIDINRNAEVLIHPDFKAILALKIGPVDRGFNIDNSPNFLTYDKATSSIMNIVKDTQERDYLASTFISTNNNLLQQKVEEANLFDEDVLSETYTATDKSFFDTLSWGNDGKPKTPPQRPPPPATNSYTEKPNLFDDAEVHERLAGIRVTKEEEADDADEFKFDYEKSPTIENSKDNNDQKLVSESFDLLGLGNEISNTYKPTTISNDDPFNVFSMTPQTTGNSMAVNYDANDLLNFDSPLTFSRNASAPNLENKCKKEIDPFEDFLAQSSFPTTAMNSNESLSKPTSKPNYNSAFFNMSTSQKTNNESKKSKASCAFDDLLSSQGFSKQNRNENKTLADMKKEEEKKTMDPIQFKIKNWTSGKERNIRALLASLNSILWEGASTYKQPSMGDLLDPAQVKKCYYKACLVVHPDKQTGTCNEELAKAIFTELNDAWSAFENGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1H4</accession>
    <name>A0A0N5C1H4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hyaluronidase</fullName>
            <ecNumber evidence="3">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1H4"/>
    <dbReference type="STRING" id="174720.A0A0N5C1H4"/>
    <dbReference type="WBParaSite" id="SPAL_0001184900.2">
        <property type="protein sequence ID" value="SPAL_0001184900.2"/>
        <property type="gene ID" value="SPAL_0001184900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001184900.2"/>
        </source>
    </evidence>
    <sequence length="271" mass="32227" checksum="F70B3712F0209284" modified="2015-12-09" version="1">MTKHLKKLEENIKTIIKDENFSGLAIIDIEEWRPTYDSNWSSKRIYREQSIKQVLDKDENKNLDKKEAEKIAIEEFDKAAIRFFNETLHTCKQLRPQAKWGFYGFPTCNENAKDRNWSFCFPNISDKTIPIFQHVDVMYPAPYIVKGQNYSIKNLFVQAVLNETRRIVNKISEDGEKQKPIYVYQKFEVSPFLSDIKDIEFFDPYYLCITFKNMIYYKVDGIIVWSTSRNMTDRCPYIKNYTDTVFGPYVKNLNEDFLMYVSLSLLVIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C293</accession>
    <name>A0A0N5C293_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Movement protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C293"/>
    <dbReference type="WBParaSite" id="SPAL_0001210475.1">
        <property type="protein sequence ID" value="SPAL_0001210475.1"/>
        <property type="gene ID" value="SPAL_0001210475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210475.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9081" checksum="18420404A77A813A" modified="2015-12-09" version="1">MAIVVVHTPHLVRVDKYCKVHCKHVIQDPGCGWGQEFVVEAVVSLSLLFFAFIFAWASRRYNRYRESQRQIQGDSTGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3J9</accession>
    <name>A0A0N5C3J9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3J9"/>
    <dbReference type="WBParaSite" id="SPAL_0001254400.1">
        <property type="protein sequence ID" value="SPAL_0001254400.1"/>
        <property type="gene ID" value="SPAL_0001254400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001254400.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19384" checksum="9CC757953F8E2E8D" modified="2015-12-09" version="1">MPPVYHYYLLVFLVHSLIITSIILTIAVKYKLRKLNNCNSSVNLRDDKKKKAEYRMTHYVTVLTFLQLCRILEDQMYYIPVKFGGHDESIYQIANAVNPFISVLWIFINSLSLIIISKTLREAIIRTFKLRVMFRKLFRKATVQNVGAFSVDCHSKGLTRITKHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4B0</accession>
    <name>A0A0N5C4B0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4B0"/>
    <dbReference type="STRING" id="174720.A0A0N5C4B0"/>
    <dbReference type="WBParaSite" id="SPAL_0001279100.1">
        <property type="protein sequence ID" value="SPAL_0001279100.1"/>
        <property type="gene ID" value="SPAL_0001279100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001279100.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44977" checksum="5CB4BC894C302F28" modified="2015-12-09" version="1">MSLKIHCTICTDDFWSGTVSTCPCGHTFHEECIKKWLEHQRNCPICRQKCTTGKLTTLFFSFTGETSQAMVEEKATNSEYKNKITQMTHELEMTKNELRRANNQLDEARSIIETQSTSLIGYENLQKEYEILSNIASDYQNLKNECKKMVRRIKVSDFYKIVSESRDSIDVSLLDEYVKDEDGSVNVTKLLEAAVKENRRIKKVLIEKQRENNELTRRKAQLESEIQEKSEMINKLRMKLTHEENSSNVPSFVLDENNSPNIGKIDDDIYIIEETPIYSQLEPTINGSFSKINYETIISIDDDDQTIQNTPNTSILSPSRVSSILDKVIASKNVSNGRMKDANSTLDKIMENRASRMKRYNSFSNKNETNSIGNLTRLKYQMQSKKSKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4G9</accession>
    <name>A0A0N5C4G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001285100.1">
        <property type="protein sequence ID" value="SPAL_0001285100.1"/>
        <property type="gene ID" value="SPAL_0001285100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001285100.1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5359" checksum="EE698053A90DD9AC" modified="2015-12-09" version="1">XLEELEKVGGEKSLKPLLTMLESTGGMAYSNGQKLEVLSGNIGPDFFCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4K3</accession>
    <name>A0A0N5C4K3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001288300.1">
        <property type="protein sequence ID" value="SPAL_0001288300.1"/>
        <property type="gene ID" value="SPAL_0001288300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="197"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001288300.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39829" checksum="9AFAD72025750CB1" modified="2015-12-09" version="1">XLINWVDEDNEEYYGIGEQVKKIFKRNDLNIGAFKVKRDTIPAINTTSTTPITKNASIMTIESNPTLDKNQTVKLKAIASNKRKKRSNMRRSIQDKTEYKRKQATKRKNTPKRSKTTKHKTTPKKKLTTKRRTTSKKKLTTKRKTTPKRKLTTKRITTPKKKSTTKRETTPKEIPTTTTIETTTSSEKPSLGIDIDSLRKKYLDQTNYYRKLHGSPDLTNSEEIENRAQAYAEKLANDFSGQLIHDPDQTYGENLAYMPSTMIDDPVKLWYDEVKNYDFNNPGFDMNTGHFTQLVWKNTKEMGCGIGRINQKNNGFYYYIISCKYNPPGNYPNQFNENVLPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C634</accession>
    <name>A0A0N5C634_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C634"/>
    <dbReference type="STRING" id="174720.A0A0N5C634"/>
    <dbReference type="WBParaSite" id="SPAL_0001340900.1">
        <property type="protein sequence ID" value="SPAL_0001340900.1"/>
        <property type="gene ID" value="SPAL_0001340900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="5">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340900.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33089" checksum="5562342F98DB7727" modified="2015-12-09" version="1">MDRRKGRAGRTQDGHCVRLLTKKFMNSLAQHPEPEITFSPLDSSILTIKALGLGDSKTFLQDAMEKIDEININEAENNLQEIDALDGNKNLTHTGRILEILPCAPNTGKCILTGLLFNVLDSLSIICTYCDSNASLFNDPFKQVETSKATMELCDDFKSDFILPLMIVQMNTGCFKKFVKDLSLSKMLSKESKDRLLKARKQTGNILHRMFQHNDFRDTGLPSNKESSVEMYTISSLLVKAVFQNIAVRNNKYKFIDNEGTIVLPVKNSALTIFRNLYDPESMFILHWQKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6B4</accession>
    <name>A0A0N5C6B4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6B4"/>
    <dbReference type="WBParaSite" id="SPAL_0001348500.1">
        <property type="protein sequence ID" value="SPAL_0001348500.1"/>
        <property type="gene ID" value="SPAL_0001348500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001348500.1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6495" checksum="0FD3C5EF89CC4959" modified="2015-12-09" version="1">KYITNLLSTFILCESTLSILHTDECVIQREKSPGAKGLKYDYIISTCFHTSRRVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6G3</accession>
    <name>A0A0N5C6G3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6G3"/>
    <dbReference type="WBParaSite" id="SPAL_0001353100.1">
        <property type="protein sequence ID" value="SPAL_0001353100.1"/>
        <property type="gene ID" value="SPAL_0001353100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001353100.1"/>
        </source>
    </evidence>
    <sequence length="41" mass="4724" checksum="D0450A9322E7411B" modified="2015-12-09" version="1">MRLSGIEPESAAWKAAGTRQSFKNFCQKTQSRGLCDFWQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6K8</accession>
    <name>A0A0N5C6K8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6K8"/>
    <dbReference type="STRING" id="174720.A0A0N5C6K8"/>
    <dbReference type="WBParaSite" id="SPAL_0001357400.1">
        <property type="protein sequence ID" value="SPAL_0001357400.1"/>
        <property type="gene ID" value="SPAL_0001357400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895536" evidence="3">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001357400.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43110" checksum="D52DE33990340BF9" modified="2015-12-09" version="1">MLVGLLLALICFSTNKGDDTLLGVQALWRHGARSPEVIFDYDPHKNDWPVPLGELTTEGMRQHYDLGKRLMQRYGEEYKLINTSYDVGEIYVRSTDVNRALVSAYSNLAGMFSESKNTYPDGNWPSPWTPIPVHTVNDTDDNLLNPTFYCPRLYQLSDERLQRKQFLIFENTFSSLFDYLTLHSGVNITDYKSLETLYVTIRVEKYFNYSQPSWVTDDIFKQMESFVNSSINYSYGCAGFGLPEDTELISLKGGHLVWQMIDNMKTIKNNGKIEKYIAYSAHHTTLISFANVLGAKVKIMGQGLIDFAASFLLELWKDENGNYYIKLFYANNAYGDFTPVTHLIRGCINQDKCSLDDFENGASAYLQHYPQDHCTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6X3</accession>
    <name>A0A0N5C6X3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6X3"/>
    <dbReference type="STRING" id="174720.A0A0N5C6X3"/>
    <dbReference type="WBParaSite" id="SPAL_0001368800.1">
        <property type="protein sequence ID" value="SPAL_0001368800.1"/>
        <property type="gene ID" value="SPAL_0001368800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="443"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001368800.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67970" checksum="1CBEBF7E5BB93DAE" modified="2015-12-09" version="1">MNVELFSLRQLLLHVPGATCEGDLKIVNGFQWPSFRDAAIARGLLDTEDNYNELFEEACESAMPNMLRNYFGLMICYWPSFTRHYDTFIKFKNYLIEDYLMKYNGNEERAEAQAIFDIRNVLQSNNFNGYTDLPEVNFDIIKIDYVEDKDVLKRLGEENLKSANEEQKNFINRILNIIVNNFSDKRCFFLEGPAGTGKTFVYTTLYYLLRAEDKIVLNCASTGIAATLLRNGQTVHSMFSVPITLYDSNFRLSKLNKLRTTMLEKASLIIIDEAPMLSKYVIDYLDQQLKKVCKNDLPFGGKVIICGGDFRQTLPILPNSTRHQNVLFSIKNMRVKEDEIDFAKWILDIGNDALQKNEDGEVDIPLNIQSTGNLVNDIFGAKNESILEKSNYAILAPTNVIVESINNEVLNTLPGDVEKIFSADSIRKDSDTNENYYNMPIENLNQLTPSGLPPHVLNLKINAVIIVLRNLNIKEGLCNGTRLRIIKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEFPFTLARKQFPVRLAFAMTINKSQGQTLSKVGVDLTTPVFSHGQLYVAFSRVKSPDCLFVKTESNKAKNIVYKEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C715</accession>
    <name>A0A0N5C715_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C715"/>
    <dbReference type="STRING" id="174720.A0A0N5C715"/>
    <dbReference type="WBParaSite" id="SPAL_0001373000.1">
        <property type="protein sequence ID" value="SPAL_0001373000.1"/>
        <property type="gene ID" value="SPAL_0001373000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="53"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="252"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001373000.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50277" checksum="8B11C71811EBF4E9" modified="2015-12-09" version="1">MPSDGREVISIHIGQAGSQIGNSCWELYCLEHGIGKDGFMSEEVKQSQKSFSFSNFFSESSHGKFVPRAIYIDLEPSVIDEIRTGEYHQLFHPEQLIAGKEDAANNYARGHYTVGKELIEAVSDKIRKQAENCIGLQGFLVFHSFGGGTGSGFTSLLMERLSLEFGKKSKLEFSIYPAPMVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICHKNLGIERPSYSNLNRLIAQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYSPVISADKAYHESLSVAQITDECFREGNQLVKCDVSSGKYMAVCLLYRGDVVPKDVNAAISAIKTKRGINFVDWCPTGFKVGINYEPPKAIPNGDLAKVNRAVCMLSNTTAIAGAWKRLNSKFDLLYSKRAFVHWYVGEGMEEGEFTEARDDLAALERDYEEVATDSDNKDAFDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7D3</accession>
    <name>A0A0N5C7D3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7D3"/>
    <dbReference type="STRING" id="174720.A0A0N5C7D3"/>
    <dbReference type="WBParaSite" id="SPAL_0001384700.1">
        <property type="protein sequence ID" value="SPAL_0001384700.1"/>
        <property type="gene ID" value="SPAL_0001384700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="73"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001384700.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50074" checksum="A7936E0818A95FEB" modified="2015-12-09" version="1">MQVVGDQRDSQTPASQEKTTILRTWKITNTGLKEIKKVILKEGQTTEEINMGAFLDKPITKKSNDHGEGQGMRYGMASMQGWRVDMEDAHDVQIAMSNEPPFDKWSFFAVFDGHAGPNAAKHAAENLLKTIMETPEFEKLLQHLKDTGGTIDDETRKLIGKGLINGFLRHDEMLHNQPKPESSGTTAIAAIVTPEYVFLVNLGDSRAIFCKKDSEVIATEDHKPYNEKEKERIVKAGGNVMISRVNGALAVSRAFGDFEYKNVPNLSSTEQLVSPEPDVYEVQRDSNADEFFVLACDGIYDVLSNEELADLVRERLIAEDDLRVVTNQVLDYALSKGSRDNMTLILVTLKQAPTVNNEIAEKEKCWVEKLNVVIKDVITELKGECEDGEKVCLEVAVRKVNESDVIKDSPIKNVTYHTRYYVDKALNDFYDGNRYEGDDEGEDKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Z4</accession>
    <name>A0A0N5C7Z4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Z4"/>
    <dbReference type="STRING" id="174720.A0A0N5C7Z4"/>
    <dbReference type="WBParaSite" id="SPAL_0001405400.1">
        <property type="protein sequence ID" value="SPAL_0001405400.1"/>
        <property type="gene ID" value="SPAL_0001405400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="N-ACETYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538:SF4">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001405400.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26277" checksum="8314175597B58157" modified="2015-12-09" version="1">MEIYKLVPLATCPHLANEVVLLLNSEWPRSDTVRQRSISKSCNMEPPMSLVLFKDESQNIPEVIGYAKLCEIPKTDESACWIESVIIKSTLRGRKLGFFLMNELEKIAIKFNYDVMYLSTHDKRKFYEKCGFEECPPVSNVGANSELFKKFSIKTSLINDRKKDYTSQNNGIKILSQENNCTIVKNNIPIPPLLPSLSSLTPPQISSSSSSIDNEAATKSQKIYMKKFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C894</accession>
    <name>A0A0N5C894_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C894"/>
    <dbReference type="WBParaSite" id="SPAL_0001414600.1">
        <property type="protein sequence ID" value="SPAL_0001414600.1"/>
        <property type="gene ID" value="SPAL_0001414600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895527" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001414600.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11206" checksum="0FD999C15345C02E" modified="2015-12-09" version="1">MINAELSLKIFILLCTCGIFINCQPIFNPYAIKYSGYIRHPSIISSNIIPVTVPGHNGRTPFINNGFGFITQSAALLNGNNVVIPPRRVVAIPSYISPFPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8G4</accession>
    <name>A0A0N5C8G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8G4"/>
    <dbReference type="WBParaSite" id="SPAL_0001421100.1">
        <property type="protein sequence ID" value="SPAL_0001421100.1"/>
        <property type="gene ID" value="SPAL_0001421100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421100.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33149" checksum="D578A5296C7638B0" modified="2015-12-09" version="1">MYIPEKISYPSTNDIDTESIIRPILSPVERMFQIAEDSNKMYEYAEKYEEKRKASIFDPDSFLEAIGLKPTTTTKAPTFVEKLFDPFIRPFKKDFERYAKESPFKSILSSTPLPNSLINNDSPRHRQPSSSIPEVKAYTDFQKLANSFHLDPNFEPLKPLKPPPSIFPLIENNNGSNDLLKSRPIKILEKFFNKDEDEKDIFGFPKPNNIELRNPFTANPLMSMFTTVKPKISVDDVIENIPKILKPVFPTPKPDDLLKFHTLLPVPTLPNPYENPLLPSNGNKLARQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8K4</accession>
    <name>A0A0N5C8K4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8K4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8K4"/>
    <dbReference type="WBParaSite" id="SPAL_0001424800.1">
        <property type="protein sequence ID" value="SPAL_0001424800.1"/>
        <property type="gene ID" value="SPAL_0001424800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000467">
        <property type="entry name" value="Steroid dehydrogenase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001424800.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35379" checksum="9140B586720AE7C8" modified="2015-12-09" version="1">MICPCTLKLFGYGALAFILLKCFCIFKRLFYPFFIASPVSLIKKAGARWAVITGSTDGIGKAYAIELAKSGFNIVLISRNPTKLNDVKQEIEKVSQDIEIKTIAFDFTNASLADYEEIILSKLRTLDIGILVNNVGLSYEYPNILHKIEGGLKRVTDITVINTLPPTLLTAAILPQMVERKSGIVINLASFAGFNQMPMWAVYSATKKYVSFLTGILQKEYHDSGVLFQAVSPMMVATNMSKVKKTSFFTPSPTQYVKSALKTVGNASETTGTFSHQLQAEILGLLPESILDYLFWSTSKTTRAKALKKKERQAAEGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9N7</accession>
    <name>A0A0N5C9N7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001461600.1">
        <property type="protein sequence ID" value="SPAL_0001461600.1"/>
        <property type="gene ID" value="SPAL_0001461600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001461600.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51089" checksum="DF1072BD7A5EA3FB" modified="2015-12-09" version="1">XFPRPSEQNIIDSCLCGLQYKTLYNKYKKFLAVNIYIDDVSLNTPIGSYSNNNGITNVSYSIPNVVRRRCTLDNIQPFIVTLSEHAKKNSYQEIAKIIKNEFEGLEVRVGEEMIPCKLFMLKGDNLAVNSILKLSASFSPKSATNQCCFCLCTYDQFQEHLSSSRIPTSMIRLESPNELFKFPLNRSLVEDSYKSLDPFHDLHEGVVPQITFSLIRRGVEQRLFSARAFYNTAVEISKQLKNHTKFHDSLNSPENITWHINNTDVTKKATLRLNGSQSVTLLYALPIIFDMLCPDGFNEEKKLTSKLIDIVRYNTSNTMEYVQVDSLDSSITAFLHLLENIEPRYSLSIKFHNLCHYKLMIESFGLPKSWSCEREESTNAVLKQLVLISKNRVNVPKTCFRKLMQRKRLLEMLIESDLDFNPSNQPVVASQVTKIIGSDGKTYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Z5</accession>
    <name>A0A0N5C9Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like protein 46</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Z5"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0001472100.1">
        <property type="protein sequence ID" value="SPAL_0001472100.1"/>
        <property type="gene ID" value="SPAL_0001472100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF114">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895587" evidence="5">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001472100.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17471" checksum="240DDAEE4671EB5A" modified="2015-12-09" version="1">MIINNLLSLFILYSFYHLNFVKANILPKQRSSGVQSLSVKGKFFCGDEPAGNVRIKLVDQDYGPDSDDDMAAGYTNEDGTFQLSGSAEELTTIDPHLRVYHDCNDGFTPCQRRWKFELPHHYIQSGKDSTIVMDIGEWNLEARMPDERHDCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAB0</accession>
    <name>A0A0N5CAB0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Low-density lipoprotein receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <location evidence="15">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CAB0"/>
    <dbReference type="WBParaSite" id="SPAL_0001483300.1">
        <property type="protein sequence ID" value="SPAL_0001483300.1"/>
        <property type="gene ID" value="SPAL_0001483300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000190">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000209">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000147">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="419"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001487200.1"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135159" checksum="81E9DEEFE7E1EE2F" modified="2015-12-09" version="1">MATKNIESEFLTARKLCGLEPLTDENYAAWKDTLSVVFLQMGKKFDDVLEGKDDDKISAATLRTVLSSNLRTKFLSYDSTSEILKQLKARYESTPMKVIVDTIKELIHVGGSPLTMMDEIANCKRRLEKENVILPDQFFIGLTLSKLNDLGNGLLHAINKDTSFSAFFSMVASSMQFMNANKVEDSPVVFKAYGEKLKPSGIVCFRCGKPGHIKRNCRVKLSAQIISEDKEGYGFVADNGPNFKLKGIYIDSGCTEHMITDKSLLINLSPAKRIKITFANNQTETLDSAGWLNLGGLILKNCYYHKSGVTNLLSSGLLDDLGLTRYSDKGLVGISDGCVFVPIRRVNRLYEVLIDKAYKVGVNASIVDSGISMAKLWHLRLGHPNRFALKDTANVDLVEKCEVCCSQKIKKIPHKKSTISTAPLQLLFADIGFPKCGKGLGDYSCYLIVVDDFSKITCVRSLKDKSALTVKDALEDIIVCLESACKQKVVQLRTDNGCEFKNSILSQFLLKKNISIQYTNVECPQQNTAERYNQTLKLCTSTLMYTMNIPVMYWPEIIVSAAYLRNRIRGPDGLSPLERAGLQLDIGNLKVIGCMVFVKNLDIDVTLLDKSQVGILVGFGKSSVSYRIALLSQRKIIESCNVTFLEDKNFLDAKKHVLEFRQSKCEDDFFDDMKFFNDKLQPVSEISSPLVVTDVMDKTFDNSSEIKNDSIASRVTGRRRQVNCMAIVDISEKEALMDDKWLKEMQDEVKKLTTFDVYETVDRKNASEVLPGRWVYTRKPDGSLKARYVIKGFKQEAEIINFSPTTAYLTIRLFLILASSLNFKVATLDISSAFLQSGLSENIFVEIPLCCNEEKSKVWRLKKALYGLRQAPKAWNNTVTSILLSLGLVQCQCDFSVFKNNDGTLFITIYVDDFLFIGKNESVIDECVGKLKEKLTLKYYGLIKENERRKFTGYHISRVNGAFKLDMVEKIEELLHQYPNIQESKTPFYDKSELDESESLNDAEVKKFQSLLGSISYIAYNGRPDITFITAKIARKAHAPTKKCWLSLLQIVNGLDLITYSDASFATPPDLVCTSGMCIYAGGKLVHWKSSKQKSISKSTFTAELYSCVSAVEYTVYVKKFLEFFISRINKPTLCIDNVPLYKSLQKDFGYTSKAKATAINFLYLKNELNNMVLKVVSTDLMKADPLTKVSNKLKSLFAGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAK3</accession>
    <name>A0A0N5CAK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAK3"/>
    <dbReference type="STRING" id="174720.A0A0N5CAK3"/>
    <dbReference type="WBParaSite" id="SPAL_0001492400.1">
        <property type="protein sequence ID" value="SPAL_0001492400.1"/>
        <property type="gene ID" value="SPAL_0001492400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000021">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028236643" evidence="5">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001492400.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37554" checksum="FD8859FAE6687A66" modified="2015-12-09" version="1">MLFDASILILIILCIFSSNVQCDESSIVLKVEKFFETPTHVNNWAVLVDTSRFWQNYRHASNVLLLYDRIKALGIPDSNIILMMADNIPCNARNPYAGKIFGETRSNKNLYTSNVEVDYKDYDVTVLNFIRLLTGRVHPSFPRSKRLLSNHQSNVLIYLTGHGGEDFLKFQDNEELTSKDMADAIEIMYHRQRYNELLFISDTCHAESMYTPITTPNVLATSSSLTHEESYSLQVDHNIGVYVNDRYAYYVSEFLKDKVNNLESNSTMKDFFDSCPITKCLSTVGVRTDLYEKNITRVRVTDFFGSKRIFTTFNEEMEIDDGWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBH1</accession>
    <name>A0A0N5CBH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CBH1"/>
    <dbReference type="WBParaSite" id="SPAL_0001523700.2">
        <property type="protein sequence ID" value="SPAL_0001523700.2"/>
        <property type="gene ID" value="SPAL_0001523700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="764"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="2245"/>
            <end position="2667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001523700.2"/>
        </source>
    </evidence>
    <sequence length="2701" mass="306459" checksum="C2D9DF9721C976F1" modified="2015-12-09" version="1">MKSPNCKKQMTPIKQQRSMDDRISVFSGSSENSGAIESYSNTSGFVKGGHIGNNNLRKFTNSVGRVGQAKETREACTKAMSISNPLRKSFKPKPLDYESFIENNLAQLKNEKNSGIVLFPRDDINEGKTKCRYGDKYKGIENINMANIEWLITKDCLKLYNSKGKIINFNYSNKYGEYDESEIDNVNSLTQPRFEIDQRLEEEKQEKLDAEHYRLPHIICEGMVLQLSSDNSILDKFRNGKKRYCIFKQDFTKNEVVVELIKNPNIKKTVDTVFYPKSAMIHTNKNRSVIVISDKSPLSDSSTSSKDKEKTLQLAGDDGFDITKWFFDIDKAIKNCLVLDSSSIISDKHNSSQEANSSTCEDMGNDDTFNDSSISSSASTRIQKGKNAIAKILRPPLVERNTLFKLYYQLSKLQTSSDRQGCVLSRTIKSSSKMFTRDAGRSSIKKDSMSLPTQSDISVACSNSISSKNDKRITIEVYDFEFKAFISPGTFEQIEPFIVKGYVFDARYNKRLSEEFSFSVSNPQFDELLKESGYGISDNKSPLTESINTIYSDSTISTTNSFENLITKDRIKVFFNLPTIHESIFLILRVERVFSNMSLEPYFKPFTVPKAAMKYKKCINQGLSKLGNYRTCIAWGKRSIFKGDCEERLKLYKCDGKLTDSDIYKYLYNYNEFQKLEKNGKLITYPQASMITRIETDVRKSMFPTFYNSSLQLAPESSGSFELDSPNQSLASKINICSPKGSPTSVFELQAFGDVIGCPYSNVVNLLYVYPVHLMYNGQKAFSKARNISCSVSLITNTGDCNNENIPRIIDTSNPSGPFLLSSECAVQYHEQFPSFNSEMKVLLPVTIKPTDHLLFSFKHISISNALSEKKVKENVESEIGYSWLPLSQKDCWIMKDDEQEFELPVSMNLPNNYANSFLPNKNSDAKYIENGKGLFKVKLRLISSLFSSEPRIQSFFQHCQNLETQTKEHTLPHSKSTEESLLSCKISSLKENGPSDVPHSVSVQNTITLGDSDIKDNGITHIQSIYEKIGRRCDGLITVSPEKITPFLYVILNRLLSTLTKISSTNVSNKIIKCIFKIFEKMNQLEKRSLFKKYILEVIGSDTFTDFENEQIHESLVKGLTPFLKCCDDDLDLMLLVFTELRVIVDIILKCMSSHIVSCELHFKERSKRFSSDFLEAIKDFVQLLVDTICHRSQDLSRDAIIQANGSLMYFLRGCLSLTDRGFIFELYHYAANKYDNYESKILRDLKFDLVQSIVYHEHFLQLSLPLLVDKDYNILRMDGLIDNTSTSLAVREDTPSGFVERFFKKLFSNTSNITELVGMGTFTPYMENFVLNEHYCSVHFPIGLLLQELKAVMREPKESRRKVIKLLRNMLAKHSVDDRYAASTVQNRIAILYSPLIRFVLENITEIEASAMSLNASPNTTISNNETSGIILKQSFTSSFESPILTTIARTPRSNPYHSEMSKFGTLVSKTFDCNGSGPNTPVKGHHKSSNDEKLLLSSIPEQATPLSSKIPVATLTERLDKHEVRDLLLSVLYVIHNLKSNVFRSIINSLDDSHLSRNDITRKPISDIKVGTLHLVRLLELVLHFFHYEPQEVFINKYLSQAKKTRPNAKVTIEFPKDSLNDDDPLIREEYQKALFAYMQECSLIQEICLIVLTATETLANHISTQSKLLSFEEMEDAFIRILNVQIKLMSEEWPENVRLHALANLGIFVTTFQKRLFINGSLTPLADLIEALLLQLNSRIVPIQNSAAALLHLVYKTNFDLFSNISPAYYRQDENGMKKLSFKSINPLSLSEKLGRSGTQTGVALAKLLGQKYLLARSVRFQKGLSTLTTIVERCSERYNENYDNAVLYLIKELKGVLNATGALLESSNDPIKLTELHIQLADSYRGSALLRYAWLQSLATSHYNQKFFSEAAVCKAHCLAIIGRELVGKNLVKIDWKFFDTINDKICVEEKVMETDVETIQPAGFTIENFTTKAEDLIENLFMAERYEAAASICSICMELQQSFSRLSEIKTSGKRHLGAYFRVIFYGKFHFGEEHETEWIYREPGLTSLAEASEKMLENVKNSLGHXFQKRLFINGSLTPLADLIEALLLQLNSRIVPIQNSAAALLHLVYKTNFDLFSNISPAYYRQDKNGMKKLSFKSINPLSLSEKLGRSGTQTGVALAKLLGQKYLLARSVRFQKGLSTLTTIVERCSERYNENYDNAVLYLIKELKGVLNATGALLESSNDPIKLTELHIQLADSYRGSALLRYAWLQSLAISHYNQKFFSEAAVCKAHCLAIIEEKVMETDVETIQPAGFTIENFTTKAEDLIENLFMAERYEAAASICMMLLPIYESQFNFTKAGSICMELQQSFSRLSEIKTSGKRHLGAYFRVIFYGKFHFGEEHETEWIYREPGLTSLAEASEKMLENVKNSLGHDNVKLVMDKDVKSGTFKDNIAYVQMTHVHPFVVKEGTDPLDYWANTNIKSFYYDEPKLDSSAPPGSTDVAKHMIKKVFLTIDEPFPNMKRRQKIIGKKEQILNPLEVACESLLKKADQIRKVLKAAKEASNHGGMQLDTYDKSFLDKLDLKGLQLLLQGAVQATVNAGPLAYGEAFSTIIQKQRYGEDEINRLIKAFKQLLHQCSEALRVNEVAVSSDQVEYHMMLKSSFEVLQERLNEYFGEDKMKIMGDDIVNDDSDLMEDVHNASIHILDSIAGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD43</accession>
    <name>A0A0N5CD43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD43"/>
    <dbReference type="STRING" id="174720.A0A0N5CD43"/>
    <dbReference type="WBParaSite" id="SPAL_0001578900.1">
        <property type="protein sequence ID" value="SPAL_0001578900.1"/>
        <property type="gene ID" value="SPAL_0001578900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895702" evidence="2">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001578900.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13056" checksum="ED05D7362F15B8E1" modified="2015-12-09" version="1">MKTTLLSILLFTTIYLTYGMPQDVKNLLNIDGMKCPICEMLVKQSELWLGKEGEERESTVIALCEKELSSLGVYGKMICDAFVKDELDNIIQHMENGDDEAKDAKKVCTKAGLCKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDC4</accession>
    <name>A0A0N5CDC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic protein NCK1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDC4"/>
    <dbReference type="STRING" id="174720.A0A0N5CDC4"/>
    <dbReference type="WBParaSite" id="SPAL_0001586900.1">
        <property type="protein sequence ID" value="SPAL_0001586900.1"/>
        <property type="gene ID" value="SPAL_0001586900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="286"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001586900.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44738" checksum="0472D2ACE33DBD74" modified="2015-12-09" version="1">MTESFVIVKYNFEATGPNELSIKKNQRLRLLDDSKEWWKVQDENNATGFVPSNYVRREKGTIADDNLLMNKNSNFGSLMDDKNSNHSSTSMKSSSDSNNLLQNSGRYIEKNNLLSPMITVEGTRLSCGIALYPYEPQRDDELKLNKNDFVEILEKSQDGWWKGRCGNLIGWFPSNYIEEQQIIPTISENEKILEIVEALYNFNAQNDEELSFDKGELLEILDHPEHDPEWWLARNSRNKTGLVPINYIKVKEAYPKGSLFNFSGLEHKLLNQTKHDTSSKFGNHSYYYGKISREIAENHLNSRGVEGDFLVRDSESNPGDYSISLKGNKRNKHFWIQVDKHSNIYKIGQRTFPSLELLIEHYKLHPIFSSDSTNEKLFLIKPLPKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CER3</accession>
    <name>A0A0N5CER3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CER3"/>
    <dbReference type="STRING" id="174720.A0A0N5CER3"/>
    <dbReference type="WBParaSite" id="SPAL_0001635000.2">
        <property type="protein sequence ID" value="SPAL_0001635000.2"/>
        <property type="gene ID" value="SPAL_0001635000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047887">
        <property type="entry name" value="ARHGAP20_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22286">
        <property type="entry name" value="RHG20_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="378"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001635000.2"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111808" checksum="C9535DCF621B766B" modified="2015-12-09" version="1">MTSRRRSLSASRTLDQTVNFVGRIGASLRLPSRKRNTTKNALQQNQLEVQQRLAQLTQLNFTNPTLRNSYSYQPTDCLSPAAQKRLLHKHLSSNTNQNTEQTFCTVSSPLVIRCGEDKQSLEFDSTNISISGDSHNISGNNFNYSKSDTIKQQMKRRYIKEGAAQLTSISDLLTHHRYLFLFNDLLLVSKQKGENSYKLKEKVLLEKIWISSITSCSSSFLIGYPSSHSISNYVAHFSSEKEKAEWFEVLNQHILRKRISKSTTISIAVKIEGRQQIIRKEIQNGISSTEIVAELVKELDLPVATNYELGFETHASGVTIFNGIENVYAVLMDVAAKSGAVLSESQLAHLDVCPLVTVRLVLRITSTSRSTTASYLKTQLKKVLSRPESKRLFGKELEGSMPPQPILTLIDHIFLHGINTEGVFRKSPKMGTVQQLKAQLDNGQVPDFTQHSVHCSASLLKEYLRSIPGNLLLNGNYHLWMEVVTEKNHEKRLNSCRNLLKLLPPSHSVLLRSVLRLLRRIALSPNTKMNVESLAVCIAPGLLWNDSDSLNAGQNVPKLAEFLIKNTPELFNDFTEDGPLLPQKLAQSTDSGLSDDSENQRRSITPDSLLLLESPFSDASVTTCDSPTRIHIEEIPSSNCATITEIRKNKNNLDDERTPVVSRENSQKTRDFSITNKYQWRSHLHRASPGEPNCNNHQISHSPLSFKSSLASVENDLRDLSPISRTITYDHSTKRFINIGPCDSSNSSSILSSPEIQIKNDIFSSGSRVISPIKPNYKFDSEATNSHVLNNLPSSKFRDSRGYYSVYKHQKIDSSDSTKTLTESRPNSITCTGKDDGYSSSSISSSSTTNKSSYSKKPIGQANSLNWKSSVNRNSFQPRTSDITSNYKFKELPLNEPMLLTKMSSMNNDTAWKGQDLSNKANNSLTSTITSPPPVQISSITAHKPLRRPPPRAAPEIQLSPLEVNWSVTSLRSAFQNNDSKPASIDTIYVSRDMLSTINAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF31</accession>
    <name>A0A0N5CF31_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF31"/>
    <dbReference type="STRING" id="174720.A0A0N5CF31"/>
    <dbReference type="WBParaSite" id="SPAL_0001646900.1">
        <property type="protein sequence ID" value="SPAL_0001646900.1"/>
        <property type="gene ID" value="SPAL_0001646900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001646900.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51367" checksum="B553D9449F312D17" modified="2015-12-09" version="1">MGDQDDKTLPINANDKIGPTTVISDTSFPFQEKENSGLIDIPSGVIIEEKYQFIKPLDEGGCGSIFLVKDTLSGSQYALKAVSNKVKESSILSFEVQVMKRLKNKKNVCQLISSGKNNRFTYVIMTLLGQSLFDLIIQEKFFSKSTAIRVSIQCLLGIKQIHEVGFIHRDIKTENFLKGHGTERIIYLVDFGLVREYVKINPSGKIEKRKARVKCGFRGTTKYASINAQENQEQGRCDDLISLLYCTAEFLKKLPWDFDDNEKVKSVKKETPTKDIFPDLPELASCLVYLYGLNYYVRPDYHKVFTFYKTEMDKLEVQFDDPYDWEISKNPTQKPLPKKKENNDSTTTVYDNKKKGGSNRTTKNGSNLKTRIAKARRSLRKTSRRIRNSFRRRNNRNNDDSNSNIINENVFIEKNVETEKANKKKEMSSSINLEEIEQEFKKNIIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFP7</accession>
    <name>A0A0N5CFP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFP7"/>
    <dbReference type="WBParaSite" id="SPAL_0001668100.1">
        <property type="protein sequence ID" value="SPAL_0001668100.1"/>
        <property type="gene ID" value="SPAL_0001668100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001668100.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21018" checksum="1D121364C8CBBB94" modified="2015-12-09" version="1">MLRSDIGPAFIANPVTDYLTSNAVVERFNRILRSAIRICKEEPLTTITTHFTYVYNRSKNTSTGFSPAQTLLNTPDCITNELSIHNGCSGIHNVIKETREQFYEPELKRHGLKLKDGDLVLRKIMHRKDASTSAKNQPTWKGHFKVVKHLYGDTYEIQKVGDHHRTRSAVDKVHADRLKRYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGL4</accession>
    <name>A0A0N5CGL4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidohydro-rel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGL4"/>
    <dbReference type="STRING" id="174720.A0A0N5CGL4"/>
    <dbReference type="WBParaSite" id="SPAL_0001699000.1">
        <property type="protein sequence ID" value="SPAL_0001699000.1"/>
        <property type="gene ID" value="SPAL_0001699000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF48">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="57"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001699000.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50124" checksum="33DACB168F6F90B1" modified="2015-12-09" version="1">MLPRRKILSAPFIWNEGGFLKNFAIKANNDGVIEEVVPFNELTEKEKLDVVMLQDQIVLPGFINCHSHSFHRFLRGKSCIGTPGEENFWKWRDNMYSLIQNIDYKKMLYFCKTTFKEMIEAGITTVGEFHYLHHSNVNEKNFNLDKAVIEAAVETGIRLVLIVTLYTFPGLNRSEELSQPQRHFECIVDEFIGHLNNLKKTIKNDNVSLGVAAHSIRAVDENSFKKLWLYCKEKNLPLHIHMEEQPKEIEDCMKYLCKRPSEILVENFKTLGPVNLTAIHCSFTTRKIMDELKRNNTKICVCPLTEGYLGDSIPLLDAEDHIVIGSDCNNRISMLEEARWLAFGQHLKNNNRNHGRFEADKLIHILTENGGKSLGIDKTVGKLEKGFKLDFVTIKLKSTVMRETKNQDDISDSIIFSCDNKEIGTVYVNGKMLYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH45</accession>
    <name>A0A0N5CH45_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH45"/>
    <dbReference type="WBParaSite" id="SPAL_0001716700.1">
        <property type="protein sequence ID" value="SPAL_0001716700.1"/>
        <property type="gene ID" value="SPAL_0001716700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF108">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895870" evidence="2">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001716700.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47920" checksum="5D54EDE9303095BE" modified="2015-12-09" version="1">MFKNIYALLLLLISIDGFTLTDPLSDEVICKDLDPDCPSRKIFCDHEAYRAVMILKCAKTCDACDEVNKMIEEMEVEEENENKQLPWTHGGGSTEGEVDEDNEESDNGGEESEATLKEVEEVSETTQGPEVTDIENIVEEEEVEEEPKKVEEEEETLTEQSAENNKESQPLPDVEEEEEEEVHEVPVNKIKPKPFGQFNKFRPLPEKMFTKKPRTTTTPKPKSKTAAELLKRIENENKRRCVDDATDCEERKNLCVDAKYGPIVKKVCRKTCGICKPVSISSSTYMSLTSKSNRTRVKGTDFYSKWKESRNTTPKPVIITMQHMRNQTRNMNNNKNTFGRKTITKKVTSQTLPRNKNPYTNILSGRYGSRGAEETDTSSTAAVVDKAIDCVAKQALCNHKGYKNLMERMCPKTCSATFAYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH51</accession>
    <name>A0A0N5CH51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH51"/>
    <dbReference type="STRING" id="174720.A0A0N5CH51"/>
    <dbReference type="WBParaSite" id="SPAL_0001717300.1">
        <property type="protein sequence ID" value="SPAL_0001717300.1"/>
        <property type="gene ID" value="SPAL_0001717300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF372">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP76A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001717300.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42930" checksum="665B8E21F2D573F1" modified="2015-12-09" version="1">MSTKNDAILETQAIFTIDVLKQLILSEDEIVFSPYSLTLALAMCYVGARGKTETEFNKLLSPYSEKEEYFRMLKNSIEDVHKNSCNLGSISVANRIFLQNDYAVEEKFKNDIENYLAASFENVDFNDGEKSAKIINDFISNATNHKIKNLIRPNSFSTYTRAIITNALYFKCQWNQIFCEQLTVDDEFYITKSEKKIVKMMNRKSLSLYGSNNNFHIVKLPYIRTDIEFVLILPKERNKLHSLLRKMDRNSFINVIRPTYSQKEVILTMPKFRTEATCNMKSVLNKMGLVLPFNETANFTGITSAEKIWVEDVFHKVFIDVNEKGTEAAAATIIRLSGGGRLPEMEKIIVKADHPFLYVILNKEKILFSGIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH55</accession>
    <name>A0A0N5CH55_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH55"/>
    <dbReference type="WBParaSite" id="SPAL_0001717700.1">
        <property type="protein sequence ID" value="SPAL_0001717700.1"/>
        <property type="gene ID" value="SPAL_0001717700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895868" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001717700.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22629" checksum="390DC4B04588A46D" modified="2015-12-09" version="1">MVIIMLNLSIFLFLILPGTLLACSGSNNDYSIVQSPTLTLTFNPPALWTYPETDAQATLSFFPGQPLTQIEAQNNAQNDIKNAVVNSLTEIGIDPQGKNVVANYQAQMVHDCYKVLPTGVTNAVGSVYGILENGAITKLATLGGTAALSADACAKRNFAANPLTYTENVLTATVQINNLITTRYSLRQLANSIMSKLSFGNSVQFVGEITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIJ5</accession>
    <name>A0A0N5CIJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIJ5"/>
    <dbReference type="STRING" id="174720.A0A0N5CIJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001764900.1">
        <property type="protein sequence ID" value="SPAL_0001764900.1"/>
        <property type="gene ID" value="SPAL_0001764900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001764900.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28029" checksum="DA31EC7584A8ACD8" modified="2015-12-09" version="1">MLLNASSEEQVFFRGKTATTVGGCDSKCRYGCRVDETNYHIVTQCKAHSYNRRHDMIVYSILRKLKTKYQMNTVLPFGRSVMNFEDSSIKVRAGHKLLTETPLVSNKPDLLIHLKNNDTIYVFEISVPHINNFLLQEKIKHTKYCKNSMVEITADNVDKVCRDLNLMDMLERKERCKVKFGSLLIGCYGEYLRTEKAIETENMLKEIGFTKNEIKKLLEEACYYVMTETSRILMKHSKKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIM4</accession>
    <name>A0A0N5CIM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TransThyretin-Related family domain</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIM4"/>
    <dbReference type="WBParaSite" id="SPAL_0001767900.1">
        <property type="protein sequence ID" value="SPAL_0001767900.1"/>
        <property type="gene ID" value="SPAL_0001767900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895926" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001767900.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15752" checksum="468AA94384930848" modified="2015-12-09" version="1">MKYFIILVLFIIISLSNVFTQKSSSNGRRIDVKFNITCDDDKKNNKIVVNMKNNKTNSFIEEQKDSCYRNNFNFVNKKISDDSHLDDILFTIYYENNSSNKTFIKPNKDNCESISKGKDFSDKDSEFLLQCDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1S7</accession>
    <name>A0A0N5B1S7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1S7"/>
    <dbReference type="STRING" id="174720.A0A0N5B1S7"/>
    <dbReference type="WBParaSite" id="SPAL_0000002900.1">
        <property type="protein sequence ID" value="SPAL_0000002900.1"/>
        <property type="gene ID" value="SPAL_0000002900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="62"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000002900.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45126" checksum="A4DAD66D5AC84C51" modified="2015-12-09" version="1">MNGNINYKTIGVTLDRNGKVQVSEENIKKLCNELEYFSRKINLKTQTVLKISQDLSLTHTKLEESEKNCQKLEIDIRRGNEIIEGLKKEFEKDYSKLRDKCNQLVKEKETLKKENEYLLKENDQLKDEVRNLRKDCLGYRQKIAKLEVKEIKSVIHKEQSFENEELKKRSEELKKDVSILLCDKEELIKERDCIKEKMERLSQEIIYLLNGDPKAIDEDIDRIISDNRIMKAQLENMKQERGLTKAALKKYKSLLGKHTYNNNNDDNEPFDCQMEDFFSNRNSKVITFKQIKELLGSTCEGVTEEDYKTLTLLLVDYCNDKKLALTHQRNANKILGKKVSDMELKIKNLEKNKERICKSPNKDFLNELLTKKDVCCKNIQVDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2F6</accession>
    <name>A0A0N5B2F6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA_pol_L_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2F6"/>
    <dbReference type="STRING" id="174720.A0A0N5B2F6"/>
    <dbReference type="WBParaSite" id="SPAL_0000026300.1">
        <property type="protein sequence ID" value="SPAL_0000026300.1"/>
        <property type="gene ID" value="SPAL_0000026300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000026300.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11969" checksum="2A04314F20786EBA" modified="2015-12-09" version="1">MDYSNLDKLEILDPEGLVEDPTCLTLVIHEEDHTIGNSLKHILVMMPEIEFCGYNIPHPLEDKIILRIQSKKGYNAVDLLIKGLDNLTYIFKGVQDKFEAAIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3W2</accession>
    <name>A0A0N5B3W2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3W2"/>
    <dbReference type="STRING" id="174720.A0A0N5B3W2"/>
    <dbReference type="WBParaSite" id="SPAL_0000076200.1">
        <property type="protein sequence ID" value="SPAL_0000076200.1"/>
        <property type="gene ID" value="SPAL_0000076200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000076200.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="103219" checksum="5FC41DD682D2BF6E" modified="2015-12-09" version="1">MEWIKAVYERRCNLTDEDTRGRAFGIFKKGNIDDPKNYRFINVTNSHYKIFMKYLNSVIVDQIEHRIPKEQIANKKGRSCLDGIIINRLIQKKTVHGQQIAQTWLDMQKAYDSLDHKKLLIVLENLGIHRDFIEIIKKAMRCWKFTVINGKETYMNNEKKKKKPTVIHVNRGIYQGDSLSPTLFVCSLIPLSWMLNQQPRINLEDPNTEANVVTTMNDDEVEDEGLYNHLLFMDDIKLFSINAKCLNEMTKICEKYGLEIGLKINPLKSSYSINQGEQAEEPLINFEELSTVYKYLGIYENHKTADEKANLQELYKVVDEKLKLILESPITVGNMIDAINTCLMPKILYVFSHERSELIKRKIYLDMDLRIRKALNTYGVKFQNLSNARIYLPRSRFGLGLKSTETEIDKIQLKNFIHIKYSEVFRKMNETFKMMENDIIIIASKYNINMSFEEGLPCINGTIGSEKEAKKKISELVDNFAYKRWAEHYTRKKEFPKFVINNKLICPWLRTLNIEPRKFKTITMTQDDMHPMLNPIFDKESKCVLETNSVKCNHYDNIRHVGSYCEHSVSWRRRRHDNVLHTITNVLLRKLKQKMVDLNNYKKCYKIDDNTELRIDQLNYTSESLVHNKPDIIYETKDKIIIGEIIHVNRGIYQGDSLSPTLFVCSLIPLSWMLNQQPRINLEDPNTEANVVTTMNDDEVEDEGLYNHLLFMDDIKLFSINAKCLNEMTKICEKYGLEIGLKINPLKSSYSINQGEQAEEPLINFEELSTVYKYLGIYENHKTADEKANLQELYKVVDEKLKLILESPITVGNMIDAINTCLMPKILYVFSHERSELIKRKIYLDMDLRIRKALNTYGVKFQNLSNARIYLPRSRFGLGLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4N6</accession>
    <name>A0A0N5B4N6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4N6"/>
    <dbReference type="STRING" id="174720.A0A0N5B4N6"/>
    <dbReference type="WBParaSite" id="SPAL_0000103700.1">
        <property type="protein sequence ID" value="SPAL_0000103700.1"/>
        <property type="gene ID" value="SPAL_0000103700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893736" evidence="1">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="44"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000103700.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51284" checksum="B97ACC92446D29BA" modified="2015-12-09" version="1">MKFSGRILSLLFLLTLLGVVESFKIGNIFNDNFDTCPPNNCEGDISVVVDASSDGLTQQLFQKEKDLIKNNLSSTWNDYTRIYLTWYDKGTTSVNNFGSPYDKDEFDKIIDAIPYDSGTNITKVLQFLSGNSPDTKYQSTIVFISTGTSADILNSKPYADDLKSRGALIFVILGNILTKDILSFLNPTAVVIWDFRDETAQSVVDGVVNNLACASKCSNGGTTTPGTQIFTGFPTLAHTTTPPSHVFTGFPTIAHQTTSPVHGYTSFPPNGHSTIPPSKGPYVPAKADIIFSLAASSTKISIDQFIAQISLFQTDDVLSKSYTHYERFGFVAYSDYPQAVVQLNEVSNRTVVQHMIVNGINQGDGNSLTNLVLGLADKNFLNYTPKTKQKHYIFLDNLDIGDLLTARDEITNLLKNKQVSVYLISFNSLIDQEILSTFQATGTFEWDITDETNSDLIKFISKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4U1</accession>
    <name>A0A0N5B4U1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4U1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4U1"/>
    <dbReference type="WBParaSite" id="SPAL_0000109000.2">
        <property type="protein sequence ID" value="SPAL_0000109000.2"/>
        <property type="gene ID" value="SPAL_0000109000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="58"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000109000.2"/>
        </source>
    </evidence>
    <sequence length="454" mass="52275" checksum="08A586A95AB4893C" modified="2015-12-09" version="1">MSVTFETYTDYDFLPNNEDVIIENDFLFNVSHNIPIKPFIAAIICIVVSIIIVVTLIGNLMVCLAVFMVRKLKQPPNFLLVNLAVADFSVGFFVMPIAFLSLFENRWILGETVCRLWTSADLTLCTASILNLCFITVDRYLIITKPLRYCAQRTSKRIFIYILLVWCGALLVSVTPLIFLPWKMDSNVCQVPQNQFYQIYATFFSFYGPTAVMVTLYWKMLMAAKRLTEKEERSVSVYLDDSDKKNLPLKKLTKTSSYVITSDNDLSSSESGSKFFYNRRSSAFLNVVRMPLISHTRRHSQQSHHAVRENKARITLGVIMSTFIICWLPFFIMALMKSFKLIDAPRWLDNLTLWLGYSNSMLNPLIYCKYNAEFRVPFREMLCCRFRTLKSVVRHESFTKKYGPLKPQKIKENEVEGKQLALLTNKLPVPEVPDSSPTTSKKNSTNETQNNVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4W9</accession>
    <name>A0A0N5B4W9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4W9"/>
    <dbReference type="WBParaSite" id="SPAL_0000111900.1">
        <property type="protein sequence ID" value="SPAL_0000111900.1"/>
        <property type="gene ID" value="SPAL_0000111900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF877">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031611048" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="132"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="372"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000111900.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74646" checksum="CAD08088D8DD99A9" modified="2015-12-09" version="1">MYRLLLLTIFFLLFNLNEFKFHREKFLNGKSTFTEDSLNDHLKKMDELRRLQVRLFGKFEANDDINYKEEHIEPAEAEKDRKPYENPFLFEGDIILTNDQFDSILDAVKEQIKENEKNSNSEENDTGDRKRRTLTSSFSSRWTQFPIPFYINTRTGVDSDAVLAGIKSWEDNTCVTFKQYSSLPSRNGLEFILGNGCYSNIGKYSGGTQQISIGYGCTSLGTVTHEIGHSLGLYHEQARYDRDNYVTINSNNIQYSYLSQFTKQSPSTMVDYGVAYDLGSTMHYDPYAFSSNRAITVETNDNNYQTTIGQRMGLSFYDIKKINFAYCNSTCSVKLPCENKGYTDPKNCTKCRCPPGLTGKLCTDVDVQTATCGEGILETSNTLQTLSKSGRYTCYFLIKAPTPNHKIYMTLSQSRFTQATTCQDNYVEVKYSSDIGQTGARICKSSTNVQITSETNIAMIIYKGGSSTSFTLRYRHDPPDVITPPTTTTTTTTTTTPKPTTERPTEEPYTEILTITPEPPTMPTPPSTMTTLTTTKRPSTTTTLTTTKRPTTTTETPTGPWGYWSSCSAQCGGCGVRFRIQGYGTSVQRQFCNLAPCMGNWCCDPFEFVSPYYCKPKVDGNTYGTIQISSGSSENINQPIYPYYPGFNYHSDNFITGSGRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4X4</accession>
    <name>A0A0N5B4X4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAM184 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4X4"/>
    <dbReference type="STRING" id="174720.A0A0N5B4X4"/>
    <dbReference type="WBParaSite" id="SPAL_0000112400.1">
        <property type="protein sequence ID" value="SPAL_0000112400.1"/>
        <property type="gene ID" value="SPAL_0000112400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="193"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="256"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="471"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="721"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000112400.1"/>
        </source>
    </evidence>
    <sequence length="967" mass="111925" checksum="449B058D8F95AEFA" modified="2015-12-09" version="1">MLSEPENDDDCSLNVSFCHTSLRPISPLSNHGYDGNYMDNQYKIRKSSKSPRSHKTAIVDPSPVLPRLDSRPEIAAWPTPPSNNILNSSTPPAKKVTVAKTTSLTSPNQKPQVLCKKLSQPVSPHSALSNTTTTAVSSPRSIDKTSMLNTSLSVKTEANNLCNESSQLYSILKVAACTGGNEKSNDNSRFVKGRESELQRKIDNLEETLVEYERQKFSVIGSFSEYQERVAERERKLDEEYSRKIIALSEEVLSAKKDFETRMKNFQALQEKFEREKECALEKLRKEHQKEIQLLEQRFSNSQLLNLEQKYIIEIQRLEEERKCLKREKECLGNTFEMKLRRAQTLYETELTAAKMLYKRELEALRDHEDALKEELLARQEEYQDRIKESEIKSKEIKEKLNIATKKIDELIRSIKQKDELIYELNFKVEQAKAMEVSFKNNCKERDQLGTLTKNHLQMLESEISENQKICTVLRNEKYELESQIKAKNEEIKNLKDKNNFLEVERNNLLSQSESQSEMQKSQLQAMEAVLESVTKEKEACKENYERELMKEKEASQEREFLMKKEFSSKLNRLEEQYNNLRDKMGDCDDESLEKEQKMVAEMDAMMLENRKLREKIMNLEDQIDGKDCNNCDKFNRYECAVASMLRLTDDFNVGDDKERDNDNFNILFLRLETLVNKVENLESEITKQPQINNTEKFDREIQYDISEGNNGEEEVNDKIIEEKDEKINKLEEKLLKNENERENLSNDLSCALIEIENLKEQVKKIESALQFEKSRRIHVSPSRGIKIDTIHLNDILAGNIAELSHAKSESSIVKFVKGNTPEINSENETITIMKTTIEEKDKEIERLLELLKNNEQKGNCKEERKNSSSSDGSDLSSEKKSLKEKKESKKLQPGSEKSTDYRSKSPAVNKALKLPTNPVNVSADNTTFEEKKKLSPNKTSSFRVKKDPATVNNQDSKNEKRPAWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B522</accession>
    <name>A0A0N5B522_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B522"/>
    <dbReference type="STRING" id="174720.A0A0N5B522"/>
    <dbReference type="WBParaSite" id="SPAL_0000116900.1">
        <property type="protein sequence ID" value="SPAL_0000116900.1"/>
        <property type="gene ID" value="SPAL_0000116900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000006">
        <property type="entry name" value="Protein CBG05566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055262">
        <property type="entry name" value="GGT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF73">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="418"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="470"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000116900.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67013" checksum="41F9FA4E6734060C" modified="2015-12-09" version="1">MIEIPSYKRVGFYLSSFIFLLIIVVYLFFSISENKPEWPKPSYTLYDKFNNAAVVSENGLCSEIGRNIMVEGGNSIDAAIAVQVCIGVTNFHSSGIGGGFIMVFYDKKSKKCITINAREVAPLKSSKSMYMNETENSLIGWKSIGVPGEIHGLWTAYKKYGSKKIPWSRLLEPSINLANNGFPISKSVERFIKVRENELENFPELKQYLTNPVTKKYYMDGDIMKRQSLGKTLHDLAYSNDPMYLFYRGYIGRVISRDITQNGGYITIQDLYEYSSIVDEDPIIVNSLGKNLTMCGCKPPSGFVVTQSIVSIINEKYKNKKIIDLNNPKLYHRIIEAQKFAYSQRTKLGDIKFVETAEFVMNYMKSDKFIQNVVKNLPEKAQNLKYYTDDLYFDNMDNGTSHLSVIDNEGNAVSLTSTINREFGSLCLSKELGIIWNDQMDDFSSPGFSNSFGYPPSPSNFISPKKRPMSSMSPMIVYNNYSGEVRLVIGASGGSFIISSVAQATMRNLIFNQTIKEAIDAPRFHNQFIPSLTKYEDGVPDSITTILQMKNHQSLMKVQKFKNNVIGLEKRDDGFIYGATDPRIAIHNYPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B573</accession>
    <name>A0A0N5B573_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B573"/>
    <dbReference type="WBParaSite" id="SPAL_0000122000.1">
        <property type="protein sequence ID" value="SPAL_0000122000.1"/>
        <property type="gene ID" value="SPAL_0000122000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000122000.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30015" checksum="F95086DDD4881EDA" modified="2015-12-09" version="1">MSIVFENSNILSEEQSRSLFSKILIFSQISGVLAFLSSAYWMGSFDDGGFGWSDDPEKQFHYHPTFMTIGFIFLYGESIIIYRALRSEPKRITKLAHLCIHTVVLIMVIVAIKAVLDSHDYHKDAQGNPDPIPNYMSLHSWIGATIILSYFAQYAVAFYTFFIPGARQSTRQFLMPFHQLFGLIIFIIVSVNALVGISERAAWKHTCWTKDKEFCGKQAVSNFLGIFIICYCVSVVIILLNPRWKRRPLPEEETLHRLSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5F1</accession>
    <name>A0A0N5B5F1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5F1"/>
    <dbReference type="STRING" id="174720.A0A0N5B5F1"/>
    <dbReference type="WBParaSite" id="SPAL_0000129400.1">
        <property type="protein sequence ID" value="SPAL_0000129400.1"/>
        <property type="gene ID" value="SPAL_0000129400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="282"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000129400.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="65075" checksum="695B83E7C508091F" modified="2015-12-09" version="1">MVTGEPISKVRINFNFKNVQTMRLNSDLKALTDEITNTNMMILGICETKRNKEETFVLDDLYHCYMGKADKRIGGMGFIIRKEFAKYIKFVEFQEARLGKILFKIGRKTILYTIGYAPTSQYTLDERESFFDKLLQFTKTPADFKIVAGDLNCKLQGIDKTKYGSKYYELKYEDKSENDLVNKFSAISGFNIVNTKFVERRNRRWTWCSPNKKTFQEIDYFLVSNLKHVINFNVLNWKVFNVRSDHRCIEIGVLVENIRNKFKKKKPCNVHILKGGYDSDHSFLDFNSKTSIETDYENKLLEERRALKNNLINTAIINKALRLSIDKDLDLYKLQKLTVLKNCSRKRLLKSGLFKKNRISIDNDTIKQFYTSLYAKKLNLRRTVRNTNELQPILKEEISEAGVKQGDALSPTLFCIALNRALRKANLERFGERYGNTCIPYLGFAEDLVLIAPSIHKAQKMLEELTYQTSQLGMKINQKKTQFMARIVKRKWVKGRGGKRVKKLEFTEDPVIKLNGEMLEKVEIYRYLGQIVSIKLKDYNSNELRERIKKETITVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5G7</accession>
    <name>A0A0N5B5G7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5G7"/>
    <dbReference type="WBParaSite" id="SPAL_0000130900.1">
        <property type="protein sequence ID" value="SPAL_0000130900.1"/>
        <property type="gene ID" value="SPAL_0000130900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000130900.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19861" checksum="0ED7F6897C6638B7" modified="2015-12-09" version="1">KWMPQSDLLNDKRLSLFITHGGMGSITELSFRGVPAVVIPVQGDQYRNAKLVERQNYGIVMNKLDLTNPDILIKNIKTILDDVTYNENAKMVSKRLKKRPIGSKRVLIEHIQFAAEFGRLDMLDLGSRNMGMIEYYNLDIIIPVIFGFIILVSLVSYVIFKIVKKLFTSKAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5N2</accession>
    <name>A0A0N5B5N2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5N2"/>
    <dbReference type="STRING" id="174720.A0A0N5B5N2"/>
    <dbReference type="WBParaSite" id="SPAL_0000137700.1">
        <property type="protein sequence ID" value="SPAL_0000137700.1"/>
        <property type="gene ID" value="SPAL_0000137700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="354"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000137700.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="76930" checksum="BAB1F3B02E774DDE" modified="2015-12-09" version="1">MEEKSDALMKMSKAELSSLLSSTLSTQPKVKSLFAGQMDFDLFLLSNHHFFCNLPHLKVESEKVGKLIQTLSDDVVKELAEFFGIKFMSSTFNDSVIEYLQGRYNKKESRFSVIARLSDTSKKQDTLFDWFSRLRSMTHQFKAKFGTELCDLVIIKDVISQLHEPLKIESIMLSPLRSRNLISQIFYLIKKRQRKNPRYRKRSSGTKQKDVDAINFDSVDFLSTCSKFIAVNLSSTVSCDMKVDTGAGDSVLPFYFYKKNLSNVPLQKTSKICTSATNAPIKVYGYFNFSFNNVSYSCYVADVARPLLGSNAAWMAVQLLLSSRMDEIKHDPNLLSNIKQKFPNLFNLSGKQTGVHDYVIDDDILNHPPIFIPPRLKASTKPLRICMDFSATVNRVTSTRCTLLDNFDVLYRDLSDACFFTHLDLSSAFLQLRLSDSLSSIMTFKVLDTTYKWLRCPFGYKNSPYHMQTFLSWVLRDCVEFTRIYYDDILIYASNMSDLTKFTFQVCEQLDRYNFVLNEQKSVFGSNVVCFLGWKIQDGKRYWTDAAKNSILSIRSPQNVDDICTILGVCALYADAIPNLMNFILLLSPLCHRPTYLSCDASSIAIGGVLDQQVNIGGKSIRVPVLFFSKALSQLQINYSQTEKELLALITGFQKFKYYIMAIITRHVNEIINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5N9</accession>
    <name>A0A0N5B5N9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_S9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5N9"/>
    <dbReference type="STRING" id="174720.A0A0N5B5N9"/>
    <dbReference type="WBParaSite" id="SPAL_0000138400.1">
        <property type="protein sequence ID" value="SPAL_0000138400.1"/>
        <property type="gene ID" value="SPAL_0000138400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="87"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000138400.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27135" checksum="83AF67F3A385C11D" modified="2015-12-09" version="1">MIKYFLIPISNNDSISGSYVLVNSSPKYTIIYSHSENSNLYHYTQIFPNTQSIANFLIVNFVTYDYSGYGISTDTPSIENLQETLKAIIKYVNAELGIKKDQIILWGSSLGGTLSADIMVDEKDLCGLILYDTPNTMLEYLCYKDKQFNYQKYQKYSKYRKDFNTLDAVSKINVPTLILRNQYNTNVSYVACFKIYRAIKNPVPCFTIYDNNDLFFTRETLWRVKEYLEYDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5P0</accession>
    <name>A0A0N5B5P0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B5P0"/>
    <dbReference type="WBParaSite" id="SPAL_0000138500.1">
        <property type="protein sequence ID" value="SPAL_0000138500.1"/>
        <property type="gene ID" value="SPAL_0000138500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000138500.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50982" checksum="7B99FC8819C2C48B" modified="2015-12-09" version="1">MAPTITDNNYHDISDNIFPDKVWMGIFQYIPLKQRIGTFSLVSRAMRDLARKSVMEVAFYMEDMDYLDDNRLNLFLRQYGYYLKYINLDLFKATLCTSQGNWRQTVLNITSIGKNITSLDVLVCDRHKLRDTDVMKIFKFCNKLQMIRVDAQFLNGYCFANAPKTIQHLELDMCFRFSADALTKLLNXXXXXXXXXXXXXTSRPPMVILTENAEAWTSVPPVLGDDPNSPPKLRIYSLFTDCIYKDKIAPYSVVSGDCVSQLCPGYLEPELRIGNRYRTLWAYIGPNASPKVANTNNSNNNGKIHDNIETPKNNYMNRNNSYPRYGNNSNTNPTFGRKPFSNNRGGGRRDYNGSRYGHEHQFRHLKSYGDSGDEFVGKNVNTQYDMKHRNVLQHHQSQQQQHPLQHHQTGTTHNFWRKNNKFDNGRGNMFEEKMXITIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B634</accession>
    <name>A0A0N5B634_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B634"/>
    <dbReference type="STRING" id="174720.A0A0N5B634"/>
    <dbReference type="WBParaSite" id="SPAL_0000152400.1">
        <property type="protein sequence ID" value="SPAL_0000152400.1"/>
        <property type="gene ID" value="SPAL_0000152400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
        <property type="entry name" value="CCD_aECM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23626">
        <property type="entry name" value="CCD_aECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893941" evidence="2">
        <location>
            <begin position="17"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="aECM cysteine-cradle" evidence="3">
        <location>
            <begin position="776"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="683"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000152400.1"/>
        </source>
    </evidence>
    <sequence length="823" mass="92662" checksum="8FF26D8192347491" modified="2015-12-09" version="1">MKYFFLIYLYTTVVLSEIVQRTYRKDGVKEFQIVKYIKGNKCDCSCQCNPQNQLKIFTETTTSLPITTVLLKEDDETKNVENINLGNILSTNGKKIKLKTVDVSAETNIVTNEDIQPTTINPTVSSLDESSSSGNLNNFEETPPAVTTVGNIQFHEKLTSIKVNEEESALKKDVETTSSPKNDDVNILTTTIIPVITDQLSTAIDEETTTTPADIETTNNFIAITNSKENQIKEEKLETTEHPSISVVSTNDNTESTATEINLPTESIVGTTILSPSLSTEESQITETLETLNFEPTTQKLNLESTPQTINFEPTTQKLNLESTSQTLNFETTSQTTIFETENKTNLDETTTSTRIKDIAENESVDTFSEGTTISTQKNILINDKSTVKEVNDFSTTTQKTIKNNNNSKITLEKENVVNELGLKISDSNDTSLEEDIPEAEFSDSEKNEHISSNITNPTTISIDDITTTKTIELETTTLSFTNTDISLNLNNIATSTIQTTTETESGDVAFKIEEIDDKSEEEATEIVDSTILTTTPSIIAESVTKQTEIFNVSDVIQKIDIVTEKVDELDNLDSQLTKEIYNIVSEIRSKFENTSTSFKIDENDQRLIQVKWSKLINKLREKLAILKSKKVENDETLGTVDFVTSQTTTPSITIFSKKYKEPIKTDFSINENPSEEKVPETIDTLENRLEKAKLLREKEEKAEFDEKLSIEKTLDALAEKERLLREQADRKRLHFSPNQLNKAKTISDTTLIRQPIRRIPDHEEIDDSIKLPQIQCEPVRNFIKIFKISDPKVWIQENCQFVKQYFPSASCVQIKDILISCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B761</accession>
    <name>A0A0N5B761_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000188900.1">
        <property type="protein sequence ID" value="SPAL_0000188900.1"/>
        <property type="gene ID" value="SPAL_0000188900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000188900.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11322" checksum="6F8A97AADD4579FB" modified="2015-12-09" version="1">XVLLAVQYSLQDDTTTYATTPAYMYSYDNGNSDFGTTQESPLDYVNREKRSLKDKFKDVKSKAKDLVGKAKDGAKKLAKKTKDVAENLVDKTESKFRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7W8</accession>
    <name>A0A0N5B7W8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7W8"/>
    <dbReference type="STRING" id="174720.A0A0N5B7W8"/>
    <dbReference type="WBParaSite" id="SPAL_0000214200.1">
        <property type="protein sequence ID" value="SPAL_0000214200.1"/>
        <property type="gene ID" value="SPAL_0000214200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020420">
        <property type="entry name" value="Atypical_DUSP_subfamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01910">
        <property type="entry name" value="ADSPHPHTASEB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000214200.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23053" checksum="2ED6ACBC127A5F65" modified="2015-12-09" version="1">MDSSSSIISEISKIKSRLKNVETTVVNENGIASVEKKDKEGYFIQVKSDNTKKREGFVVDLKPDFEIAQVTENIFLGSQDVAMDEVLLKTNNITHIINVSIDVPNYFPDKFVYLSLKIYDRPDTNLNNYIPTINNFIKESLANFPNPKIFIHCNAGISRSVSVTIAYLILCCGLSYNEAYEKIKKVRKNARPNDGFMKQLKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8V2</accession>
    <name>A0A0N5B8V2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Dr1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Down-regulator of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Negative cofactor 2-beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NC2 beta/DR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8V2"/>
    <dbReference type="STRING" id="174720.A0A0N5B8V2"/>
    <dbReference type="WBParaSite" id="SPAL_0000247500.1">
        <property type="protein sequence ID" value="SPAL_0000247500.1"/>
        <property type="gene ID" value="SPAL_0000247500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000247500.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20125" checksum="C888A7790C05B108" modified="2015-12-09" version="1">MGDEDNEVGLPQKGLNMIIKDIIPDMRVANEARDLLNQCCVEFIKIVGQEAQKMSQTDQRKTICHDHVRNALIKLGFSSDYVEAADSCLGECKLAAENKLKRKNSRLDKCGIPEEQLYMMQQQLIEEARQQEAQRAQEENDRIAAMGGETYREQCFMHTANQIMAAAKYGSDDEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9L7</accession>
    <name>A0A0N5B9L7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9L7"/>
    <dbReference type="STRING" id="174720.A0A0N5B9L7"/>
    <dbReference type="WBParaSite" id="SPAL_0000273300.1">
        <property type="protein sequence ID" value="SPAL_0000273300.1"/>
        <property type="gene ID" value="SPAL_0000273300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000273300.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29842" checksum="D5F1C6D37636E5FE" modified="2015-12-09" version="1">MLSKRLLSNYIQSIAKFSTQLPANGGLELTNEEKWRRRIELRKPKLQRDEVIPPKVYYTPEWVLNKEGQDKYKDVTPMQKYGMNPEKWEFYNKTIWPSGYIVPETGLPKSKEVFHCREQIHFSPKRMWQACELVLGMNVDEAILQLELQQIKGCLILAEVLGEAKKRASDEFKIEFPSDMHIAEAFAIQSKIIKGLRMRARGAPGQIKYRYIDLYVRLEEGEGPGFKSRLKPKDGFEKGEDYIEYLRSRSIKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAB9</accession>
    <name>A0A0N5BAB9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAB9"/>
    <dbReference type="STRING" id="174720.A0A0N5BAB9"/>
    <dbReference type="WBParaSite" id="SPAL_0000298900.1">
        <property type="protein sequence ID" value="SPAL_0000298900.1"/>
        <property type="gene ID" value="SPAL_0000298900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF91">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="473"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000298900.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="93707" checksum="383553971CCA07B6" modified="2015-12-09" version="1">MARKIVGVPLVKKTSYIPTQDELEKIFQTCLAPEVKNKCLNQSVAKLIPILNKFLIDASTSFHSGDYKTAQIYASRVAIITKEAIQKYRNEHQYLPDLKDLCSRSIEILENLKKIAAENYISNSDLDESYETTNDHDNNWTVKNTIKPTDLFSLIKNNKKILLVDYHGDRNSYLSIPQYPNFERVQLCPMVLAKYLSYNELCNKFPIDYQNKLKKSFYDFIVLMGDKNDDENEKDIREEILIKGFTEIKNISSNESFPPVLPLQGGFKEFVLTYPNYVKKTDNNSLPSFTYHQKFLEFLNNHRSESIKNIQEYPRLGRTTPPKNNHEKEVKELLEATKENNLSFTKKTTDVDKNISQTPKTINYNLPKDKPIPKPRGQIKIPDKNNKIELTQESINSVCESLDKLNETEKRPIIPDKTTKPQVSGPQIPNRELKENIVKKRKYFDDRIIEIYSYSIKDLERQSYESSVPQGMTGLTNLGNTCFMNSILQALFHLPEMKNLFTIGNIIKYINESNKFGTQGTITAVFTSLMDLFWSGRFRKIHPECFLITFADQVNRRLADRCQQDAQEFQIYLLDALHEDTNYVSTRKSFKQNYNGDNLFEDFNDYKEKVEQFSYSKVNSLFNLRIVSTVSCSVCMHQSVTFEDSVQISVELPIQIQSTRLSECLTNHFSVEILNDGWKCPKCDVIRKSTKTQRIWELPEILVIHKKRFAYVNGCCDKNNVYVDFDINDFNVSSFVHEQNVNNVKCLYDLYAVVNHMGTLNSGHYTSYVRSGDQWLECDDDTVTPMSDTNHDIKTKTAFMLYYRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAY5</accession>
    <name>A0A0N5BAY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAY5"/>
    <dbReference type="WBParaSite" id="SPAL_0000319900.1">
        <property type="protein sequence ID" value="SPAL_0000319900.1"/>
        <property type="gene ID" value="SPAL_0000319900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000319900.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18536" checksum="CF43C90BA0CC8900" modified="2015-12-09" version="1">MICWIFSTTIAFWALPNWLFSLFYCLVVISVITLLIINCTRNSSSNSKASSVEAKIRNEGISSSASKARKSTISGRRGSLSKNSTKAIEVSSDTTKRQDSKRELLEKIFLKLNNTKKVGVSMPSVELDQINVKQYKDKTKNTKDITSEMVIEDTDYVNLKKIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCM0</accession>
    <name>A0A0N5BCM0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCM0"/>
    <dbReference type="WBParaSite" id="SPAL_0000376600.1">
        <property type="protein sequence ID" value="SPAL_0000376600.1"/>
        <property type="gene ID" value="SPAL_0000376600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894358" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000376600.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10239" checksum="49F57057DC3BECF3" modified="2015-12-09" version="1">MKFILIVQQLLLSVCFTQNFSSAIIWKSHLVENTSMVSTFQYLTYMKTIQPDREGFKSIRLANTKTYSKTAPTNCSLFLPFFEINILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCT1</accession>
    <name>A0A0N5BCT1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCT1"/>
    <dbReference type="STRING" id="174720.A0A0N5BCT1"/>
    <dbReference type="WBParaSite" id="SPAL_0000382600.1">
        <property type="protein sequence ID" value="SPAL_0000382600.1"/>
        <property type="gene ID" value="SPAL_0000382600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF17">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="11"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382600.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25253" checksum="89B51EE15335777F" modified="2015-12-09" version="1">MALFGTFDPEMLKMPLGFIKVLQLPFALIAFTTMDGWGFLLEYKCDEKVIQKAIIDRFALSSIMLPMCNGTKTNLWEHSFGGTALFYGLISLLSLVFIGLMLFVYLFNLELYATDNRLPHADCITTCILGICWVLVAISWWSATSKVLEDTTNENIVKLLNDKHFCGENSCVSGSYSHSSTLTISVLAAWGCAILFFSNIWFAYKETDWFKNRQPFPEPQMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDH1</accession>
    <name>A0A0N5BDH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDH1"/>
    <dbReference type="WBParaSite" id="SPAL_0000405700.1">
        <property type="protein sequence ID" value="SPAL_0000405700.1"/>
        <property type="gene ID" value="SPAL_0000405700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000405700.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14581" checksum="5330E72260144D6A" modified="2015-12-09" version="1">MTVGLFGAHAITAAAIDPLPVTIGLCLKPQNELYLKSLHARKINNSEIIVNYNNKSAIIKIELNNKINKTLLNIIEDNRTSFYPEILTTRIKKDDCLKHLETQLNSVDVMMFVVIGLIGFFAIVLCTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDL8</accession>
    <name>A0A0N5BDL8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDL8"/>
    <dbReference type="WBParaSite" id="SPAL_0000410100.1">
        <property type="protein sequence ID" value="SPAL_0000410100.1"/>
        <property type="gene ID" value="SPAL_0000410100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000410100.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45140" checksum="940A9E3949AFD77E" modified="2015-12-09" version="1">MNKSFYIFISISFCFAGNNSNTFVNIEARSKKSILFKDAPPYPTSPNSILYFAEKKINQSNLNLNLKQLSSVTCLTFKKQATRVNKIGINFLIGSNDTVNLTSDKEKPTLISLSLDTYKDDKLFFYYLGIALGLNPESSRYDRDEYIDIVWENIDESYKQYYKISNNGNKKNFNTGFDYSSVMLLDRFYGSKNRKPVYNSKLSEFYHRMINLNSFFTHNEVKLINSLYCNKNCDLKKIFCRNGGYLSKDCRCKCPDGYAGNTCSNIVDTKNKCGGKAAIVPSKTVETISSRLPGTCFYFFYPKPNTQIKLTVDYLKMSSDENCLLKSGLEIKYRNDKGATGFYLCGKYKNITISPIVSRVVIRYYAKSNNSEFKISYNQVKVKNIKEIKTRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF72</accession>
    <name>A0A0N5BF72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH cro/C1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF72"/>
    <dbReference type="STRING" id="174720.A0A0N5BF72"/>
    <dbReference type="WBParaSite" id="SPAL_0000464000.1">
        <property type="protein sequence ID" value="SPAL_0000464000.1"/>
        <property type="gene ID" value="SPAL_0000464000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000464000.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16588" checksum="3D00590C98C65AF9" modified="2015-12-09" version="1">MAHIAEIRAKMPDGVQVKAVKKNSEIAKAMRSGNIVETAKKFNAGGNKQHQAVKNSLKLAEETEELHHDRIPLDLGKLIQRVRTELGYSQKDLAVKINEKQTVITEYESGKAIPNQQIFSKLERVLNVKLRGKDIGKPFPAKKVPQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFT1</accession>
    <name>A0A0N5BFT1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Endoplasmic reticulum membrane</location>
            <topology evidence="2 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFT1"/>
    <dbReference type="STRING" id="174720.A0A0N5BFT1"/>
    <dbReference type="WBParaSite" id="SPAL_0000484300.1">
        <property type="protein sequence ID" value="SPAL_0000484300.1"/>
        <property type="gene ID" value="SPAL_0000484300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733398" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="11">
        <location>
            <begin position="18"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000484300.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51361" checksum="5642367081918EEC" modified="2015-12-09" version="1">MYGIVYLLTTFFLLATSAPSDLEVSVARDIDISSQIVKNTLVYTIKNNGKQPLKEFVQIIPKAEHGKLAFISAQVDKTTKFKVTQKQVSGVPSGFVSYVVDLSKSIPAGGSEKLTIEYKVTQYLTPYPEEIKQLDNQFVVYRGSSYTPSYYALAKDATTFKIPSGKVHSYTNVSPSKQSSGKITYGPYNNVNAYDWKDISIHYENNSPFVVATHLTRWIEVSHWGNIAVEDSLEVVHRGAKLVGGFSRVDYAHDRRRSSQPSVSSWTTQLPKGAKDIYYRDEVGNISTSEVLHRAKSVDVEITPRFPLFGGWKTDYILGYNLPSSVGLFYKGNEYTLKLPVVDKIYSNFVIEKVTVKIVLPERSTNIKLVTPFSVTKLPSTTHYTFLDTVGRPVTVFEVSNVVDNHVQPFTLTYTYEMFSLFIDVGIAIGAFGTLFAVVIFLTRLDLSIGKVDDSKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG98</accession>
    <name>A0A0N5BG98_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG98"/>
    <dbReference type="STRING" id="174720.A0A0N5BG98"/>
    <dbReference type="WBParaSite" id="SPAL_0000500700.1">
        <property type="protein sequence ID" value="SPAL_0000500700.1"/>
        <property type="gene ID" value="SPAL_0000500700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000500700.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37504" checksum="F4FF18DA7178E6D0" modified="2015-12-09" version="1">MVHKKNNDNKIRFNFKSKPFFKSLNLDKNQKTNIPNETMEDYLTDLFNEEDTKDNGLLRQWLNETQFEQQNIVNIWNEELFENELKYSKRWKAAGLNGIYLALYKQLPSAKMFLKNWCLGVLKGLLTNTKKCTYSLSEILNSSQLEEIAYADYNELKATYKYLGIDEDQYGYNMEENVERIYEAIEKFLNLVFSIPLFIGDMIKAINTCILPKVSYIFSHQGEPTLRNKIAQKIDLIIPNIYGLKIEYEEDHLIIKDIIFESEKKCNKYIVESIDKVDEPYWLTEYSKNRTYPATVVSQKLFTLGHGIMFYHQNCITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI77</accession>
    <name>A0A0N5BI77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BBP1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI77"/>
    <dbReference type="STRING" id="174720.A0A0N5BI77"/>
    <dbReference type="WBParaSite" id="SPAL_0000566000.1">
        <property type="protein sequence ID" value="SPAL_0000566000.1"/>
        <property type="gene ID" value="SPAL_0000566000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000566000.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="82492" checksum="52AC3EBEA17144E7" modified="2015-12-09" version="1">MFEKIKKFWSSNSNVSRTRKSSPRFVRTKSGRSISTFTFKKTSRPSHSKEGDYATPPVVGRPPNTLPNVAVAPRDDVYDNLHAHQSQKTIRRPSVPSIEDEETLTLLNQDTVAQSPPGGYSDNNTSFCGFPGRESPSIRGTDHWLGSAKEEYLRHYRDSERPSLNVNPSSTLNYRSYMMPKTRRTRSFAHLPGSSKQSSASSNVSQGASQVYNSQPGIYGERGAVRRQEPSLSSSGFVSNISSPVCRDRYRNVDSESPYRVVETRYPRYSNSSELLSPPRNPRVSVGSVYKPSPCSTPIKGTSNIYGNARNAQDVFFDKSSRCGVSSAVSCQRIDEIEESLRDIQRKMSTSTSIQTPSNVQTDGSQQALLSILMDKKNEADRLREKVKKLENRLQMQKCDFAEETEKLQLEAENIRHKLKLMTEKFNRLDQEYRRYREATLVTENDFQKSLDDMDKIKKDYETEISCLKQKLTSVLVMDDDKSSSMNEANKLLEEENAVLLNKLDEKEEEITKLKNELNHHRSFKILNDDEYDDDNLLVLDEFKDENSTPENGSKKEETFKSVSSALSKIHLSSLHSPSNSSGFGGSHSHGFISSPLMEKPSNSLTKNTVAGSLSYNLNDISNNDKTATLMTIQPRIQRIIKDSNEIGKRLRMISKCFSEISSNIVDGRDPGFHKLASRFNDSSDSDDDINNFENKMSYNSLQFEDVIRKHQEDIQKAEKFLSQVSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJP3</accession>
    <name>A0A0N5BJP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BJP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000616600.1">
        <property type="protein sequence ID" value="SPAL_0000616600.1"/>
        <property type="gene ID" value="SPAL_0000616600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13565">
        <property type="entry name" value="HTH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894367" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000616600.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25066" checksum="A55AB94408163308" modified="2015-12-09" version="1">QCCQNVVFALLCYTSSNAVLMPQKQNQQINETFGENLVFASTVQRWFKKFREGSENLENEKRERPETVLDNDVLREVVEANPRTTVRELARKLNVSKSTVSRHLQEIEKTKKLDRWIPHELNDYQKLSRYEICSSLILRNKNDPFLGRLITCDEKWILYDNRKRSGQWLDKDESPKQFLKPKLSPKKIMVTVWWSAVGIIHYEFMKLGGTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJU3</accession>
    <name>A0A0N5BJU3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJU3"/>
    <dbReference type="STRING" id="174720.A0A0N5BJU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000621200.1">
        <property type="protein sequence ID" value="SPAL_0000621200.1"/>
        <property type="gene ID" value="SPAL_0000621200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057001">
        <property type="entry name" value="RYYR-CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23674">
        <property type="entry name" value="RYYR-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RYYR-CCHC" evidence="2">
        <location>
            <begin position="358"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000621200.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="106203" checksum="FA4F1BB1662A1DC3" modified="2015-12-09" version="1">MDSHNDQNETPLFEEELEDNVNLNKEEEMEELQGVDDQIESYSGVKRRRMDSSGLVDGEVVGEESELIEEDELIDVEGDDGMPPEAIVYDNNQPYVLEAEESVGRKGRKRNPSQGYSQASGPRVYTVQNDGTAVPLTPQRQYYNTRGQGRGRTSLSEYDGTPSSVSRRNTEKIDWNNEQVEEIVQRYEENPRCGNMRDVARQISTVTGTYISHSTVFKQLQKRRRAREAEGIEYSEPQSYEYEYYDQDGCMDESKYHDTSTDYPNTTGNSSMLNNSNVTQISTGTPKVFMLKKVENTSGSGPRYDPVQLTPADEKPIFKKPSNQRMGEKAGSEENYDHVENRFHGMMKTPLESLNVKILLTGRFTESILAIPEENGLYREYFLTNTRQDGRVRYYRCSKCCRLRKTYKDIIEPKIKVLDGCILGDFRSIVHHEECKPITELEATVKQIDRDCRRRVRNGEMTPHESWIEGRERLVRHLTANMPKGSEQPSYEALANLFPSYKKVKQQYFRHKRMGKVDKPKQSKASKMAMDDKQFGNMLKKYKLTLRGLETNSADETFLLMCDRGQGILVFASDKDLRLGGESDILCGRSSSEINCEDGKKTVYTVHAKLNIADAFEWVPILYAVIERRDQKNFFDIFALITQRWHEMGVSPRFERFFCEFDRHQIQAASEAFGAQFVSVLYMDYLRVVLNTTKNFHLNKYLGDPNPALEPIRFWVRSMCCVPLLPPNYVIPFWRFVLAKAPELSESEIGDDLEDINKQMSVMLGLINENWMDEGIIKNWNHWCSGRYTAIPYPPGYDDYIHKNNLVFSDPLHITNILHTIHTMQAAYEENSSILQENPTSAIVLSQDYKEFDIKLSSLQETFEQELENIIGPNGTVGWQAVIPILKKYIENVVDIIIPLKDAKLDFEDLNGDNVSSQDVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKD5</accession>
    <name>A0A0N5BKD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKD5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKD5"/>
    <dbReference type="WBParaSite" id="SPAL_0000639300.1">
        <property type="protein sequence ID" value="SPAL_0000639300.1"/>
        <property type="gene ID" value="SPAL_0000639300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000639300.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12410" checksum="B2142AC0D23787F1" modified="2015-12-09" version="1">MEETLLPKPKVEKIITHTEDEISKAEGFEEVDTRPPTPQKAQLAYYRPFVPDPVDEQTIGNPERGQIEYHDASEISVPNYVESHSLPRPPSRKADAMFYRPGVDNVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLQ1</accession>
    <name>A0A0N5BLQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000684700.1">
        <property type="protein sequence ID" value="SPAL_0000684700.1"/>
        <property type="gene ID" value="SPAL_0000684700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="148"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000684700.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33938" checksum="478F334B9E30502C" modified="2015-12-09" version="1">MYVTMKQMLEEIIKDHQYVHAKYLLLTKISLLGNGKAFIPEKRKYLNIYTGKFLTHTPRLIIEEFYIHNKLKYICNGRTFNSYQMALKYVMNEKRNNPIRYTRKPSSPILSQLEYTDWIKEKVYCRKFWMTLWGTCDYYCYSKKNFRVMIEKFLLEINYYREKYGAGKLVESKKLFTAALNYLREIVSLGSVIDITKFEDVEKASLAKAPLIMNHWFGEHKNYKWNTRFGSTETRHFTAMVWKSVSKIGIGVVQLGNYIYVKVIYDKKVNIPNQFEENVLKKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMF7</accession>
    <name>A0A0N5BMF7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMF7"/>
    <dbReference type="STRING" id="174720.A0A0N5BMF7"/>
    <dbReference type="WBParaSite" id="SPAL_0000709700.1">
        <property type="protein sequence ID" value="SPAL_0000709700.1"/>
        <property type="gene ID" value="SPAL_0000709700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000709700.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30309" checksum="9C57771830536A2B" modified="2015-12-09" version="1">MQADDITWGVINKGHCSYKVQLSKQKLFCKNEYNLTGVCNRVSCPLANSQYATVREEDGICYLYMKVAERSHMPNKLWEKIRLPNNMTQAVNTINEELLYWSEFVRQKCKARLVRIHQYLIRMRKLRLRSMHKKITPIPRKIERRERRNEEKALIAAKLDNAIEKELLERLKEGTYGDIYNFNRTAFENVLEHPDLQEQEVQEEVEYDEDEDDLMEREFVADFDESDSDDIEDGGYGHGKSHYDESDDDEDALEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNE2</accession>
    <name>A0A0N5BNE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A2M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNE2"/>
    <dbReference type="STRING" id="174720.A0A0N5BNE2"/>
    <dbReference type="WBParaSite" id="SPAL_0000742100.1">
        <property type="protein sequence ID" value="SPAL_0000742100.1"/>
        <property type="gene ID" value="SPAL_0000742100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF166">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="1">
        <location>
            <begin position="245"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000742100.1"/>
        </source>
    </evidence>
    <sequence length="1207" mass="141054" checksum="6F3B33B0D776836B" modified="2015-12-09" version="1">MVGTNYLIVFSTTNTKIIDMILFIGSNLCQNTNYFVSSKKTILFFNDTYQGHIKGPDNGLALMKVYDKRITFFDNSNKLKDDFWNLEKLLNLDGFFSSKNVFNPLPPEIEGDIIRNFKPINDFFDEIFEICKNFINTKTFSPQNKQLTFGNSSYWISNKCTNLIKEAIKNLIQRNKEEQDFYNDTKLSSINVVKQIFKNMPAIKNRYTTKKLSQNIYDDIIIEDDNNNYDNNIRNSEIRDFFPEVWIFDEFTLDDNGFASFNFIPPHSITTWIVDADFWKPSTTYTCPIKYNQELEYRKDFFIEINLPSTIRALETIDISVTVHSLSNSSFDNLYICMDKGTKNSCQNRGRDGSLADNSHFSLKSTTVNNVATKKFEVIFFEENNNEIISFSLRRHVEDDKTFACESNDVYDIIKKSVKILPDIRVDFKSTFFIINPDKKSELFSENELDKDKNFIITEKRDEKTSELITNITIVPGKDEIVGNLMVTLSEPRMYHMEDNNNDRRKRDILSKYGDSHIYWIMSELSSIFYKKLKKDFINEFIIKEEIPENEYLNIDYSNTLWANIIKLKKYMVECDKYDFFVDTIDNAKEIKTCTIEDVIKGDNVWITMLNTMMICDLYTSDAKQNNKDEMFFNINKLLDFLKISMKDGNLIEYILLPFDVEKDDKKYILYGIYLHVLNSCKFYDKSKNDNEINEIFSQFEDREKEDILSTLFYISSSKRGNDYKRIFAWNDILYCFNYNFKKMPWIQEKIDECEDIFRGSQRYISNPDTNMLINILALYAVTNNFSIPTNYPNVSTSELQDYTLITRNKRSDTNLANEIFLEQEIYKYIIFDMKKRNYRHKKMLDIRMECIPSCHFIPQEDYGSDGKSKVIHFPSQTKTILFKSKGNGKKVALVEGNMLTKLNVLKNEYPLKIDVKMYSEKNDLTHIVTIKNLKNQNLDMIQFEHGLYSAGYELKFNNDEGYVIFEDKDNIKYKTKPYRTDNSVVFLIGPLSTDKDTLSYNLTQKAVKAEANDIKLMGTKIILRHPIKGILGKIIVDNRTGFLKNKGDAKEKDSDVEYLCLQNSKKCFCGEGTSNDMCKIEMTDRIERSFNKDLYDKKKFLLVGEITNITTVEENEDYRKFTIVLRAQSCKTSFDVNLHVFVRTTNNSNVKCILFSKGDDVMLSGNVENTKSSHNIYHMSNGDVLVRIKENDGAAKTIVKLPFIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNJ2</accession>
    <name>A0A0N5BNJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000747000.1">
        <property type="protein sequence ID" value="SPAL_0000747000.1"/>
        <property type="gene ID" value="SPAL_0000747000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000747000.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37069" checksum="78F6E01057EE8FF6" modified="2015-12-09" version="1">MDFLSLPDDIKNMIFSMLQWEVLDNVRLTCRELCLFLERNYRRIDKRGLSVMCVYCHKWKPNTEIIGIKYKSRSETTNNGADDIYFLRRAKRVHFTDLYMYKTFLQRFDFTKLVSLHFIINAKTDVVKLFNNCLNRGSCLKEVVLEYTGIPGEESMSDILEFILKTKNTKNICLRFAVPKPNKNEKFECIQSNGLEEINNSNNTVESSSARVIGNLIYHSPSTCRIELASQIDNFYSNVMESFFKVEKLTKENVCKHKSMKTVDFKDCSASQINIILNAFIKYNYETACSWSSNRGRLYITGLKNCPICGTSDSFDLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNP3</accession>
    <name>A0A0N5BNP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNP3"/>
    <dbReference type="STRING" id="174720.A0A0N5BNP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000752000.1">
        <property type="protein sequence ID" value="SPAL_0000752000.1"/>
        <property type="gene ID" value="SPAL_0000752000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000752000.1"/>
        </source>
    </evidence>
    <sequence length="859" mass="97886" checksum="E50711C6A42DF71C" modified="2015-12-09" version="1">MDYFYKIKDTVSQVAAQASKVLPGNPITREYEVKELIATAGPGLLWKIYNGYKRSTKQKCAVWFFEKNDIEKWSKDEKEQFLNIIRKNVLTLTRIRHNRILIVEHGIEESRESIAFCTEPIFASLANIFQPTSVPSNLDLKDYELEKLDISHGLFQLGEALSFLHIDLKMVHRNICPESIIVNERGAWKLGCFEFSCNEAINSQNIGNTITFSCLNWDSQKTAVSQPNLNYIAPEHVNQKECYPSSDMFSLGVLSYACFNNGKPIFEHKNNLHTFKTNSKKLEDISTTHVAKVPPEFQNDVKKCCALNPVFRPDCTQFTRLVFFDTIQIKTLNYLENLMQMDHNQKIIFFKGLLQVFNSFPKRTLFQKVLPFLSSEFSTNQLIPFILPSIFQMAEIANNNEFSRYILPPLIPVFKIQKPYQISLLLLQKMELFLKKTPENDIKKHVLPLLYDSLLSETVRIQELCLNNIPTIGKLVDRETMKNQLLPRILKLITDGSVVSIKIQALLCLAKLMPNLENWMVSDQIIPSLSKVTCKEPGVLMAILGVYKLAFESEKFGISRELIARNVLPFLISTSIENTLNLSQFEGFISLIKQMLSKMESEQRSRLQQLSAGQEEQRGVTDFNDLINQKTSNVISNDKVAEDLEDFFRNSDKKNHEAISNPPKTIGNILESQNKPLKVAPKNETNNDLFDFSEFLKPKNNSTITQTKPSFSNVNFPSPPGVVNAINSTNSLLTFDKSFPNNVQNYNTPSLGANKTTSMCSNFESGFFSTPESTMSVQKTTSKGNNDPFADLDPFAKTKGPPMNALSANKPINATNNLFTHSQKSPKDQLNDIFETFKILRNNIHKMNFLKKFYDSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPF6</accession>
    <name>A0A0N5BPF6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPF6"/>
    <dbReference type="STRING" id="174720.A0A0N5BPF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000778100.1">
        <property type="protein sequence ID" value="SPAL_0000778100.1"/>
        <property type="gene ID" value="SPAL_0000778100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679:SF3">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000778100.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15190" checksum="FE4A2B93CEC7F793" modified="2015-12-09" version="1">MGNFLSSRRPYEDEINNDIKANPVLVFTTSGCGYCVKAKKHLFNESIDYTEKNLTQLQMDEPQKFPEYSKTLMEMTKIRTVPQIFVCGKFIGGCDDLESLIRRDALLDLLELCNKEKVSSIRQKRKELFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPV7</accession>
    <name>A0A0N5BPV7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPV7"/>
    <dbReference type="STRING" id="174720.A0A0N5BPV7"/>
    <dbReference type="WBParaSite" id="SPAL_0000793200.1">
        <property type="protein sequence ID" value="SPAL_0000793200.1"/>
        <property type="gene ID" value="SPAL_0000793200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000793200.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17014" checksum="765C5E02AEC0A615" modified="2016-05-11" version="2">KTYLIIACLIGIDKDEGRNRKLSYFLIDERDKKNFFLYQKTGSLFLKSPQPLDYEIQNKFIIKFKISDNRENSLSTICTLEVLLEDVNENIYLPTFEDVEIEGSIEENIPIGTTILTIHTTDSDNATCQPTYKIIDGDGLGYFEITEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ57</accession>
    <name>A0A0N5BQ57_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ57"/>
    <dbReference type="WBParaSite" id="SPAL_0000802700.1">
        <property type="protein sequence ID" value="SPAL_0000802700.1"/>
        <property type="gene ID" value="SPAL_0000802700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000802700.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21005" checksum="B734BE8994514CD4" modified="2015-12-09" version="1">MVITINLKYFLILLLFTTTGINTFKLFDLFNFNGKSAPKDTENSSIVQIELLNGTEETTTILPIEEELVLTTEVITNDISHNESTSDEIVHENNHEAITNTSDYDTNNLTHLITNITDIDTNNNNLNKNVTVSESMYSNETITPTINEEQLFVINENSSNSTSTITTIDANESSGQQCKFLLQKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRD8</accession>
    <name>A0A0N5BRD8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycophorin-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRD8"/>
    <dbReference type="WBParaSite" id="SPAL_0000843900.1">
        <property type="protein sequence ID" value="SPAL_0000843900.1"/>
        <property type="gene ID" value="SPAL_0000843900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000843900.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23746" checksum="F6FF170B80375422" modified="2015-12-09" version="1">MLLQANVFNNTANITDNVTTNSTNNNTKTEYQISVSQVKTDNGTSVVTKIVSNVDSKHKEAKESGETTHLINVAESGGSSICMCVFFITIIGLIGVGGIFYITKMQKKNSYENSSTESRSSSAGDTSHTPKQKNPKEKTETNTSEDNDADSVKSKKESADKPKDKVASKVEKNNNHTKGSKTKNKGKNKKKTVDLKNFDVTAASTTEKVVQSKTKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS33</accession>
    <name>A0A0N5BS33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS33"/>
    <dbReference type="WBParaSite" id="SPAL_0000867800.1">
        <property type="protein sequence ID" value="SPAL_0000867800.1"/>
        <property type="gene ID" value="SPAL_0000867800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000867800.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15329" checksum="6BE4D3055B937C16" modified="2015-12-09" version="1">MAPLPSYLLDTSTSTVIFCIGFVIMILSIMVICCTNPPNPRRNGVYIVKPPKSIKHPLYQSKCNQQQIKTVSLSVSSGPTMREGKRNHDIINSLSTTLPVPKSAKLDAIIQFTRHREYDTEYNKSGVKVISCNRSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT17</accession>
    <name>A0A0N5BT17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TGT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT17"/>
    <dbReference type="STRING" id="174720.A0A0N5BT17"/>
    <dbReference type="WBParaSite" id="SPAL_0000901100.1">
        <property type="protein sequence ID" value="SPAL_0000901100.1"/>
        <property type="gene ID" value="SPAL_0000901100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000901100.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43607" checksum="522D43606CF1F9F9" modified="2015-12-09" version="1">MIKFEVKKSTNVGRIGEFTEWEEGKSIEHKTPSYMIYTRGGCVPNLQWKNFINHLKLKQDPIIQINISSFVDSLDVIEKFGKGVSAFTNIPENFIVHLTGLDQLGRIEMGYNNNSGMAVWTKSGKKLVNSEYYRTFIDIVKPDSFTTLMDYDTPKDALKKRLQKSIARTNNYMKDFEANGEINLPRIVSINGGNDLECRAELANFLAVDPKASGFNLDMTLFSDSDQNKFYMGFDNKHIAQLFKETFEILPSKKFKIAEGAFNPTQILQLISIGFDLFDSSYATKLALEGKCFRLNDDYPHSGGGFKIIDFNEKELFEKDFSEVTKNCECYTCKNYTKSYITHLVNTKELLAPLLLTLHNISEFDNMFDLIRKHIDSQDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTY5</accession>
    <name>A0A0N5BTY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTY5"/>
    <dbReference type="STRING" id="174720.A0A0N5BTY5"/>
    <dbReference type="WBParaSite" id="SPAL_0000930900.1">
        <property type="protein sequence ID" value="SPAL_0000930900.1"/>
        <property type="gene ID" value="SPAL_0000930900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000013">
        <property type="entry name" value="SH2 domain-containing protein 3C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF8">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000930900.1"/>
        </source>
    </evidence>
    <sequence length="755" mass="86843" checksum="80C77B192655E714" modified="2015-12-09" version="1">MTTIFPTELDNVPDDSIVMDNDILYFKYNPEPPQKLHSQPWYHGLIKRIEAEFLLKNDGDFLVRDSISKEGEYVLTVQWSSKPLHFQINQETINNKTYYKFEDEQFPSIVDLINFFRTHKRKVTLLSGCIISNPINCQLIKNKLSNKNYHISEIEANYARLFNSPTQPRLPNIKHNLSQEAMLTNAKKYLNKSENNLNSLFNSKEKFNNNFQSTSNIKLNSLFSIKPQETKVLTFINEKDGEQDYCDIDYDTMENYPLPVHIKRLSTSGDEDNTISNLKKNYSNSVHDLQTNLGDTDNDHIHNNIGKTRSFSNLRFMVNPPNTRPVSISSTSTTSSSTTNSFPKGLYNFTGSNKNYKFISQPKSISRLSMGKTAASIIAEKKRGDLVPSLPQRPSEETTIEDKLNNESISELTKLEKELKQSIMSLNNLVLINNDRDSACVLDTSNEGDYDCLPLTKKCGSLSPDSVINNDTDESESENSEQTYLSAMNVFCDRLISMNVNSICRMITEEDIKLLNLHSDEENEITKLLLPFGSIIRQECSERSSTLSEVVLNTLYHFSNTKLILDMWTRVASSLLHDYGNLFSFASIYVSLKQFYEEHHYKNDSDDSSLKLIKSLLTPIFEDLKNTGEISYKNNIGTTMIPYIQPFIKIYNNDSLKDYESSLVTSYDKTPIDKQLDYMWTWLSIGRKWCQNANVFVNKAKLFYKPENEIKHNIFEMTQLRTLLSSIKQDKKKNGKCYTDKVYIDNNEKSILISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU63</accession>
    <name>A0A0N5BU63_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU63"/>
    <dbReference type="STRING" id="174720.A0A0N5BU63"/>
    <dbReference type="WBParaSite" id="SPAL_0000938475.1">
        <property type="protein sequence ID" value="SPAL_0000938475.1"/>
        <property type="gene ID" value="SPAL_0000938475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938475.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14113" checksum="6C17D6A6A9B8C632" modified="2015-12-09" version="1">MNGNNFTLQYTLPSNRTIKGKSFSCNLLPYLKELKLLNNTDFVDLTKEKVPEPKVVTAISDNHLAFKGDCHMNGNNFTLQYTLPSNRTIKGKSFSCNLLPYLKELKLLNNTDFVDLTKEKVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUA2</accession>
    <name>A0A0N5BUA2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RT_RNaseH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUA2"/>
    <dbReference type="WBParaSite" id="SPAL_0000942100.1">
        <property type="protein sequence ID" value="SPAL_0000942100.1"/>
        <property type="gene ID" value="SPAL_0000942100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000942100.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28673" checksum="D84C4B2023A702C5" modified="2015-12-09" version="1">MSFMLSQNGKLVAMNAYTLPPTLSKRHATYLELKSLVKSIEVYSYYLFNHQHLVRVYRDHKPIIGLQQTCKNHKFLDLLLTLKSYPIDIIYVTGKSNIVPDDLSLIMEHTLQSRHHLILKDKESSFKVICQSSKEIHKSDTNEIITSWKHNPTSLFITKIDEPKTPAEDVENPGNLIQEEDQTSEGEEDINDKLSEHENVRKTKITQLAESLFQNLHVNKAHTHLEGIKDDILRNIEKNQLTKYEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVV0</accession>
    <name>A0A0N5BVV0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVV0"/>
    <dbReference type="STRING" id="174720.A0A0N5BVV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000995600.1">
        <property type="protein sequence ID" value="SPAL_0000995600.1"/>
        <property type="gene ID" value="SPAL_0000995600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="38"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000995600.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47299" checksum="39819B030150FF41" modified="2015-12-09" version="1">MVSIAKTFEECGFEKEFIDYLHSIGFKEPIGLQQQLIPLMVKQNYDIILNGGARSGKTIGYVLPIINQIIKNQKQSDYMICGRSPTGIILMNRPSLIKSVTQQINNLCQGLNIGVMSGNNKTLAIISTQGVDIIVTKVEILRKSIFSLGSSVSNVKYIVVDQANLYSKGEGKSALKEIYYYIQQYGNTDITSVFSSTDLRNEQHNLEYNFLGDNVKIINSLQPPMMVRNYGNNLLSPTANLHYKQMYRSNVPNYYNNSIVKKRTIPIPREYVPIHIFDCFKMILKIVLKIFEEDPRMNIVIFTRTSHIGQYLNHFLTQTKISTCYINESTNINDLSFNTMNHNLTGTTFIMSDGVHFTINCLIKNLIIIHQQIPTTKMMYERRLSMFNNNSTQIIKSIIVDSEEKLVTFEKCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW36</accession>
    <name>A0A0N5BW36_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ras-related protein Rab-2A</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW36"/>
    <dbReference type="STRING" id="174720.A0A0N5BW36"/>
    <dbReference type="WBParaSite" id="SPAL_0001004000.1">
        <property type="protein sequence ID" value="SPAL_0001004000.1"/>
        <property type="gene ID" value="SPAL_0001004000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001004000.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23641" checksum="295B01AFAE6A2EB8" modified="2015-12-09" version="1">MSYSYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSNMVIMLIGNKSDLEARREVKKEEGEAFAREHGLIFMETSAKTAVSVEDSFIDTAKEIYRKIQEGIFDINNEANGIKLGPQHSPSSPNAPNSGNNGSSGSNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW84</accession>
    <name>A0A0N5BW84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW84"/>
    <dbReference type="WBParaSite" id="SPAL_0001008700.1">
        <property type="protein sequence ID" value="SPAL_0001008700.1"/>
        <property type="gene ID" value="SPAL_0001008700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001008700.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11491" checksum="BE9B5AA281D7651E" modified="2015-12-09" version="1">MDNNKSNLQSDEEPIEYIEKKMKLKYSYSNYSTNESNNLWMSDKIDELAVDFNREISTAYNIFRNDNQLKNNKDLEKLATTMNSVFFGPPAEYLRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWJ6</accession>
    <name>A0A0N5BWJ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001019000.1">
        <property type="protein sequence ID" value="SPAL_0001019000.1"/>
        <property type="gene ID" value="SPAL_0001019000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001019000.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22839" checksum="74B9440E02674292" modified="2015-12-09" version="1">MFLIILTFIFGGIFLYFIECYRKNITYIPQGENVIQTASVETSQTLLDKTQVSDFTRSITKYFDIQPKGSINSDLQKEATKSSNTIPTEISTTTCSTLPESQGSRISPTTTITNQTTESHDKTLIRKLTPTSNSVIKTNENNSESQKNDAKKSHKQFLEWSSNEIIQLDPASKAAEEHRLKLLEKRHEKLKDEKRNCSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWK6</accession>
    <name>A0A0N5BWK6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWK6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWK6"/>
    <dbReference type="WBParaSite" id="SPAL_0001020100.1">
        <property type="protein sequence ID" value="SPAL_0001020100.1"/>
        <property type="gene ID" value="SPAL_0001020100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000019">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001020100.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15498" checksum="36C4B14CD668E3BD" modified="2015-12-09" version="1">MEDQVQQNVGEASTQMDINEAVKRALKSAYYADGLSRGLHEAAKTLDKVAGHFCVLAESCDEPMYVKLVEALCHEHSIPLIKVNNKAILGEWVGQCKYDKDGKARKVVGCSCAVVKDYGRDEEAAKVLRDYFATQKKMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWN7</accession>
    <name>A0A0N5BWN7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWN7"/>
    <dbReference type="WBParaSite" id="SPAL_0001022800.1">
        <property type="protein sequence ID" value="SPAL_0001022800.1"/>
        <property type="gene ID" value="SPAL_0001022800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="57"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001022800.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16003" checksum="92AFEF7A60195F9E" modified="2015-12-09" version="1">MLFAGSASRYNLHKSNSTTKLAPNIDRKKSFNVRKNSEIYPWPQNVNDDEYFKYTETRKKSILTFNSSQYNKDDVEITFKDNFLNIKLSKPVKENDKISIKDINRCYKIPQNIDINTLKKEFARNGDLIIKMKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX94</accession>
    <name>A0A0N5BX94_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX94"/>
    <dbReference type="STRING" id="174720.A0A0N5BX94"/>
    <dbReference type="WBParaSite" id="SPAL_0001042700.1">
        <property type="protein sequence ID" value="SPAL_0001042700.1"/>
        <property type="gene ID" value="SPAL_0001042700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="12">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001042700.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="63816" checksum="8B4AAA7DA295C3E1" modified="2015-12-09" version="1">MLRNFVIQTSRHCTSTAPKISVPYAIKRTPTELLEALNSTVGVDKTAPHFAFIDDPITIPSTRLNKKVYFQAKELGKRAARHLASEWPTLFMYDIDEPRLPVFRPTHPLSMIPFEGTEEELIKMIEAREIKTAVECYEKIRANGVNVSDKVQMDLFKLIVYYNENDIPYQDIEKFPALRDFYSDKLVPSWNGQGLAELLFETIKKTPETYSIMIAGMCKHVSSYSFKRAKELYEEMLENNMVPCIEAFNGLISISQNEKALKYLKEIDKYKIQPTVDTMNACIIAAPKIDKMASRLDFIQKLILEFRFANVKANLYTYHLIINYLTPKMDKKKPEDYKSVISVLDQIVTNLEMVNEIKIENCSDSEFFKTAMNVAADANNSKLVERIEKIYSDKKNTVKFVNFQDEDSYYYKYLIYNIIKLPLPELEKLYKELVPRVCGVYAGSLRLLMNRLLSAPRWSFIKRVVEDSIAINLLAQQGFSNELRKLLLSVDVHSLPSEDFLDYRETLSHCLDLWSEILQYNKSAVSKGVNFLPNIDDEFITVTKKAFSKYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXC1</accession>
    <name>A0A0N5BXC1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXC1"/>
    <dbReference type="STRING" id="174720.A0A0N5BXC1"/>
    <dbReference type="WBParaSite" id="SPAL_0001045300.1">
        <property type="protein sequence ID" value="SPAL_0001045300.1"/>
        <property type="gene ID" value="SPAL_0001045300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001045300.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29327" checksum="7221B2DBBB07290D" modified="2015-12-09" version="1">MVHTCDKIFLFDLDGTLTEPKKCIKPEHWKFWIEFSKTHTLGLVGSSNINNILKQMNVTEEELTKIFPYIFSENGLDGRINGHPIPKQSLLKFIGEEKYQELVNFVFKIFSEIKLPKKRGCFVDLRSGMVNISPIGRDCTYEEREEFVEYDKKHNIRTTIVKRLREQFQNFGLDFVLGGQISIDIFPIGWDKRFCLNYLDGRFSTIYFFGDKTLPGGNDYGIYSDDRTIGHTVTGPIDTILQAQKIANNLYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXC7</accession>
    <name>A0A0N5BXC7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXC7"/>
    <dbReference type="STRING" id="174720.A0A0N5BXC7"/>
    <dbReference type="WBParaSite" id="SPAL_0001045800.1">
        <property type="protein sequence ID" value="SPAL_0001045800.1"/>
        <property type="gene ID" value="SPAL_0001045800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001045800.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="66968" checksum="DD0B3EF9F4B8EC83" modified="2015-12-09" version="1">MEINNNIKQNDSCEFRSLKKRNPDKRVFANRNLRLEKIKWIGFDMDYTIAMYKSPQFENLQFKQIIERLVDVGYPKEFLKFEYDPIFPTRGLWFDYTYGNLLKVDEFGHILKGMHGLRWLTTTEIEEQYPNKFITLTEQRVYVLNTLFNLPETHLIAQVIDYFENHSEFEQNPEKTGIQQGDLTMTYKSIFKDIRKAVDYMHIQGTMKQDVIDNVNHYVDNDPRIAKMLLNLKENDKKIFLLTNSDYYYTNAIMKYILGDKWNTYFDITVVDARKPFWFAEGSLFREVDTVTGTIKIGAKKGPLASDIVYSGGNCETFSKLVKCKGRDVLYVGDHVYGDVLKSKKSRGWRTFLVVPEIVNELNVWTKGRKYFDTLDKLEELLSETYKSYDVTTRTKPDNKELLEKLRRATIDMESEYGVFGSLFRSGSSQTFFACQLERFADIYASSCVNLMYYPSFYFFRSPMKLMSHELTVHHGSILFPSGRQGFYHNDTLGEKVRGWNREKRTSECDTFCEDEEDDDISPQADNSFLLVDRKDSDTNQYDTNSEDKLTVKNFPYTDVISHPNVQIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYC6</accession>
    <name>A0A0N5BYC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYC6"/>
    <dbReference type="WBParaSite" id="SPAL_0001078700.1">
        <property type="protein sequence ID" value="SPAL_0001078700.1"/>
        <property type="gene ID" value="SPAL_0001078700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001078700.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8260" checksum="79C503C90B7D0D9F" modified="2015-12-09" version="1">MDCLVIFHFFYQMFLDFFTSTTGYFENPYSYSISIICCHHLNFIEKEKFLLLSNAFSMNDFYYATNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYR8</accession>
    <name>A0A0N5BYR8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYR8"/>
    <dbReference type="STRING" id="174720.A0A0N5BYR8"/>
    <dbReference type="WBParaSite" id="SPAL_0001091700.1">
        <property type="protein sequence ID" value="SPAL_0001091700.1"/>
        <property type="gene ID" value="SPAL_0001091700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="223"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001091700.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33624" checksum="D672FA7943D0C438" modified="2015-12-09" version="1">MESMNSADSDVGSNTKIDLKRGRFICAIENFSIDHVDFKPCGQFVSYGEGYFCDVNKLCKECDERKHSMQSVQTFNFKLETDFEENHYFSLHIEPACCYDESEGCISVKLKFHELGDFEVMALCKFSILNAEGKEEYKSVICVKRFDENNDSYCHHVNINIIDLLDRKSMLLPNGRLTLCFEMFYLINFDLNSFYVSKWTHIDKQLNMFLNDMTRMLDSSKFYDCKIKVGNHELKVHKCILTARSEVFRSTLENKDTEHELDIIEINDFNWVVVKKMVDYLYTGEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZB2</accession>
    <name>A0A0N5BZB2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase III subunit RPC3</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZB2"/>
    <dbReference type="WBParaSite" id="SPAL_0001110500.1">
        <property type="protein sequence ID" value="SPAL_0001110500.1"/>
        <property type="gene ID" value="SPAL_0001110500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001110500.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="38276" checksum="B897B4AED184145F" modified="2015-12-09" version="1">MIEKIKYFETFPSEENDEVYDEMSRVAYFDSLLDLIKIRLHSMYVGDDVNSIIEECRCDIVNEASSKAFKKLIVKLYYDLHIEESVGRRPYKYEIFIYIIEKLLLGRSKDLMTANQLRSRITSKNSYSQHAARSHFARSFTKYGVEELEEYVKEEENKNEIKNFMHDEFSKKFNVEEEKIKQTFDKVFDYYKKEAEKENLISFASNASDISKLLEDLGLNKLIMPNEPSLNEIEAKKVGIIKKNMKYLIYVKSIEFDSYTCPKEALYNLMLLTSVTKAECALSLSKLMSLFGLIYKADESKFLGPKLKYHDKSLKVYKKIINELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZB6</accession>
    <name>A0A0N5BZB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZB6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001110900.2">
        <property type="protein sequence ID" value="SPAL_0001110900.2"/>
        <property type="gene ID" value="SPAL_0001110900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057085">
        <property type="entry name" value="Ig_Irg-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006582">
        <property type="entry name" value="MD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324:SF3">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24415">
        <property type="entry name" value="Ig_Irg-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00604">
        <property type="entry name" value="MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="74"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="868"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001110900.2"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118224" checksum="ED726ADB3B14A949" modified="2015-12-09" version="1">MRNCSIYFSVDSHTQNIKAVVKGSTGGFDVTFIMPNQSVDTTSYGLIQDSTTGYWVMETRKECEDGWQTLGPQYCIKLTSQTASWYDAYNDCLQNNAFLVDDLYASKDNYLTAYLGDYNISSIWLGLTDDPQYSDGNTWTWNHGPLGNIPLSSAHFTNWNSNANLTDPTKLCAYKTRTWDTDNCLNTRAYICQKHSYRDNFSPSISESEKLPPGKWNIKLTSTGKTTIEVRVQSRIRVLSGFLNDIHGDTIDFNANILSSTQRMATHVSGYGDNIFNTYMVNSRMFLLNNTMFEAVNYQTRLSCTYQYLSQVFSCPKNGLTSTDFYALTTGVDELGYTIQRYTAHRCVKEIKKCNHGVAYNDLCICEDSWTGTLCDTPICQNNGTYNSLTKTCTCPIGYSGAACDKAMCFDRSPIQISRDGKIFALVIENTQENLIAINSLKKSISDTLRSLNPKWFDQYIYVTFDSTNQAILKNFFDLSQFLASIQTIVPQDDTTSCNLPVFNAIIKAFGQLNHQQSVVYTITRALPSDLYNQYEFEESLVQKGPQFYYHTISGDSGCTTDMSDKVVSFLQQYTIGSGGNFLSTTGQDIGSAFSVIIPSLYYGGPLGNPTLMNNSCSGGITTYVYISRNMSDMYFYIYGQYPTITVISPTNETLQPKTVFSGQAGISPRLYIYQIPVLTDYGIYTVTITSSGNCYAQIRNTGGPEIYYGFVPSSIDKLDIGNHLDNTTVAPMNDYNHFVGSVVGDIAALEYVQMCNLYSNECQYLRFYRRNNCTYQYYSDPFKCENGLLYLKVYARDNSGFTIVRDGITQCTQYITTPTYQPTTTTMGPGIVTTTTTTGGGIVTTTTTPGGVITTTTPPSVLAAKADIYLITDVSASVPASTYANTLTNFLMQLFNNFNINPSYVNVAFSPSPGDDNVWFTIPVFNAFYGSTSLQNSINSSYYPIDGAQSPGQKQLSEIIELALNPNFINTGYNPSYKPHWLIYVTTTSSPDSNTIAAAQKVRDKGVFKIVTIAYQPTGNIEALLNMSDCFYPAYQPQDLLGLATALAAKIDYDNSIGQDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C025</accession>
    <name>A0A0N5C025_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C025"/>
    <dbReference type="STRING" id="174720.A0A0N5C025"/>
    <dbReference type="WBParaSite" id="SPAL_0001135800.1">
        <property type="protein sequence ID" value="SPAL_0001135800.1"/>
        <property type="gene ID" value="SPAL_0001135800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001135800.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41367" checksum="BAB1FE3BD26EA96B" modified="2015-12-09" version="1">MVFESGKLNNGSCNIQTKITKFNYTFSIQNFSLRTEKIGKKIKSPTFVTGWKNRSEWCLWVYPNGDRKESKEYVSVFLTLLKPDKAKAKFRFSILNDKEEEKKVFNGGDTDTYLKNSGWGKYKFVRKDFLLNESNNLLINNKLRILCEIQVINNCESKNNDNSEISMNIAIPQSKLSLDYCNMFDSPLFTDCIIKVENTEFKVHKAVLAARSPVFHNILSSTLEKSRTNVIEIKDFPVKVVKEMLKYIYKDKISNIQNMANEVFEIANKYELHRLKAISEHYMYTSLSLENVFERFSLSEKYSIKSLKECCVELIFENAGWLTKTKEWKEFVLVHPLLIESLFIKLLNISSEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0C2</accession>
    <name>A0A0N5C0C2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0C2"/>
    <dbReference type="WBParaSite" id="SPAL_0001145100.1">
        <property type="protein sequence ID" value="SPAL_0001145100.1"/>
        <property type="gene ID" value="SPAL_0001145100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001145100.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34886" checksum="7B4EE2C68DD38A58" modified="2015-12-09" version="1">MSLYPCPCNQPIPERNNKNSLGSAETTTSVIPVNCWGTSLTKIGIKDSWLPPGVRLRNEKYPEVELLSKKELLQSIDEMRRSYSVDSLGITREKYLSRWSRENTPHDSCGNYSRAVRRSYSDLRDISNYSIVNDETRSGDRARRTPIGLITTPYYTNVNYYSESQPLRKYDVFQLRTWSYPIYKYIYGREQTPSRPYSYVRDFACTPKYTPPIIGAEARGMNERRGYSGYSYMAGEHSFNISAKPWSLGSARVIASPYISKSPSNYYDPYNGYSTLRHYNRFRPRSYSARYNTFWKPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0G1</accession>
    <name>A0A0N5C0G1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Dual specificity Yak1-related kinase mbk-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Minibrain Kinase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Through phosphorylation of P granule components including meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm during zygote polarization, and thus plays a role in P granule distribution and segregation in early stage embryos following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0G1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0G1"/>
    <dbReference type="WBParaSite" id="SPAL_0001149000.1">
        <property type="protein sequence ID" value="SPAL_0001149000.1"/>
        <property type="gene ID" value="SPAL_0001149000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="184"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001149000.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="56830" checksum="F979CEE803FA54D5" modified="2015-12-09" version="1">MSSASTAASHAKYGLSSSMNGLPNVGVPTMKISGLTTLNAVDVICHKLSKSPSQDSLRSVKTRTSNSSSLDSSGKICVPNPNVPVPIINIDNSCSSGVASSGSSSSGIVEGKRGYRPEDALLSFKDRISPYETTEIFNYNRVYYVGSQAKKRGGYTSNVTNNYGFDDENGGYHLVPHDHVAYRYEILKVIGKGSFGQVVKAFDHKYSQYVALKIVRNERRFHKQADEEIRILEFLRDRDADHSNNIIHMLDNFTFRNHRCITFELLYVNLYELIKQNKFQGFSVSLVRKFAISILQCLKLLSKHGLIHCDLKPENIMLKAAKRSGIKVIDFGSSCFDNQRVYTYIQSRFYRAPEVILGTKYSKPIDMWSFGCILAELFTGHPLLPGEDEADQIALTIELLGMPPPSLLEGAKRTKNFINSKGFPRYCRMVQSPTGTISIRPGTSKRGKPRGVPGSKGLANAIRDPSDTLFVDFLARCLEWDPNLRITPEQCLKHPFITRKLPLETKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C145</accession>
    <name>A0A0N5C145_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C145"/>
    <dbReference type="STRING" id="174720.A0A0N5C145"/>
    <dbReference type="WBParaSite" id="SPAL_0001172400.1">
        <property type="protein sequence ID" value="SPAL_0001172400.1"/>
        <property type="gene ID" value="SPAL_0001172400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001172400.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58970" checksum="1F2414175F2626CA" modified="2015-12-09" version="1">MDNNHKEADGDNLSIGSIEKETNIEDIKDILSPPPDTSKSFGIDYQESLSEFEEKERQIKSEIILEESLGKNQLNELKKELTIVQEEDSQDLSDYNKELLMDDKRTSRSGSLNIEDDDMDTRRINESIQRAPNEGTIFERDNQVDNDEIEEIVQHSYSPDYPSEPPPAYMEDDVITSSKLLKNQPKPSYYNFSKEEDSDASESNYGVLSRRQSTDSNNQSSGVQGIASAFSGITNLAKAFSGPKTEPLKEEQLYQEDEDDDDDDGILESPLEENKYNKKEEESQGKVLKMTSELSKLFEMIEDYTPPNIDIPYRLLPFIPDYAPAVGDVDPFIKIPRPDEVEDNLGLTILDEPAIEQSDPTAIRLMMSKNFKDIKNVDDNDGPVRNIPSHANKSLILNQWISNVKEIQSTKQATTVPHTKNLPDIEKLMQEWPESVEKVIKKIRLPTANLNVDLKEFVDICLAIVDIPVIDSRIRSLHIFFSLYAEFKKSQHFKNMSLSDGLSQYGDTKMHTTDRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C180</accession>
    <name>A0A0N5C180_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C180"/>
    <dbReference type="STRING" id="174720.A0A0N5C180"/>
    <dbReference type="WBParaSite" id="SPAL_0001175800.1">
        <property type="protein sequence ID" value="SPAL_0001175800.1"/>
        <property type="gene ID" value="SPAL_0001175800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="390"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001175800.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="79399" checksum="AEA80EB245E296DD" modified="2015-12-09" version="1">MVLDQLRSHCLKINANKSQFFSQELRFLGFTFNEQGMLPNQDALEAITNIPPPKTLKALRRFIGKTSFYRFFFPKLSEVEKPLTDMLKKDVPFVWTEECDVAMLRIKEMIKKVARLKLPDFNKEFLLYCDASQDTFAAALIQCEDDGTMRPIAFFSRRNPERKHLLSSVELELRCIVEVMKKFRVWLLGGFTRIFTDHKLLKKLIEINTDRKLYYYINCLNEYAYTLEYLPGSKNTVADCLTRVNLRRILYPATILIRNPPFDVKELKENELKDEEEDTAPTFNYPILKEDDNSKIEEFKESSQGRESPPVKEGEEYKDNEITEKDKEELFKSFHDELGHGCYERIYPLIKMRRSWKNLSKDLKQYLARCKVCLKRNEIPKVKTMEKHVTAERPFQLMNLDLMGPFAVSLHGNKYILGLVDINSKYAIMEPLQTAKGEEILETIERCLFYKHGSPEVIRCDNAAYFRGELFRTIEERYGTKIDFGTAYWHESSAPIERLFRTVQATIAKLSEGVYSNWCHILHRAIFCYNTMYHTSTHTTPYKIIHGYNPILKYDIQNCKDKIGYIAGKESLDDREASFMLAKKMSECINAKKDQLPNKSYISKMEKLKPGVPILVKLPIQLKRGEIGKFEFKWHDGFEIVKQVGNSYMVKRRGKGRPRKIHINHIKLDSSEEEDTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1I5</accession>
    <name>A0A0N5C1I5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1I5"/>
    <dbReference type="WBParaSite" id="SPAL_0001185800.1">
        <property type="protein sequence ID" value="SPAL_0001185800.1"/>
        <property type="gene ID" value="SPAL_0001185800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001185800.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50381" checksum="E9E82749C6E176F8" modified="2015-12-09" version="1">MSSDWIVDEEHVAKLELKLKELKDRKVTSREVIKQLEEVNCFQLSCDNVELKFEDNFVDDKVLDNSWIKKKIAPQNCAVLILIRETMESQTMEYDRSEYFQCAYNNADSLHIDKDGRRMILDIFGNLLYIKDAQIESSYDLLNLIDKGDGFTNEGNVVEVVSSCTKGDKLAVSWTVFNMDYIPLYSILTLFDIVDDIGIVVCVGQKIMDSIVNCTNIASFNGKDYAVFQLHDTLPQIFEIGGNKFENISDPTTVSHIFRDYPTNSTYVRTIFYSDDQYDFCIAFNDTGKLYITVASKEKFLTRRIKCFNRVLSFIKFFKEKGNSSIYKLITTEGDGPVYHYNIEVNDGDFMETLSYQDNTWDNYDLVTNIDFNSDMSEYSISTYGGGVFVYKYFWNHSTLHHIFRVDCPITTIKYIDDSSYAILSNSGLHIYKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1K8</accession>
    <name>A0A0N5C1K8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1K8"/>
    <dbReference type="WBParaSite" id="SPAL_0001188200.1">
        <property type="protein sequence ID" value="SPAL_0001188200.1"/>
        <property type="gene ID" value="SPAL_0001188200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001188200.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26252" checksum="0DA4FB9C3A655E7C" modified="2015-12-09" version="1">MNKLYDDSDTDDDKKPEEPPAIKEDIKESVTSKQSRFIPQQVNSAIKRAPPPKKSHIPTKISKSQIFKTEQPNGDFIEKNKEIRAKVRELIKSNNLSDAIGAPEERITYFMGRKIINEYDPFNWNRYEDVVRLKAQEKLAEIEKAQTSVPEAKTTVTIKNVSEVMKSDEVSEEPESIIKPSKPKMGSFDVALRYIQNKGHVSGTGLGKYNQGTTESVEIVKSLDGTNILKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1X2</accession>
    <name>A0A0N5C1X2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1X2"/>
    <dbReference type="STRING" id="174720.A0A0N5C1X2"/>
    <dbReference type="WBParaSite" id="SPAL_0001199000.1">
        <property type="protein sequence ID" value="SPAL_0001199000.1"/>
        <property type="gene ID" value="SPAL_0001199000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001199000.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18318" checksum="FF8A945088AF1609" modified="2015-12-09" version="1">METSYICERYILDDRQLVDVFHMLDLDKDGLLGRGEIGALLRQSNYEANSKELRLIFDEVDTNENGKINENSFMSFMKPPENQNITIRQLEDKFDKFASKEDSINIDDMKNIIKELDFQHDDDHLSKTFDAADSNKDGLINFHEFVLILRRIRFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C254</accession>
    <name>A0A0N5C254_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORFan</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C254"/>
    <dbReference type="STRING" id="174720.A0A0N5C254"/>
    <dbReference type="WBParaSite" id="SPAL_0001206700.1">
        <property type="protein sequence ID" value="SPAL_0001206700.1"/>
        <property type="gene ID" value="SPAL_0001206700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001206700.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="44077" checksum="A27ABC1A7D447EA0" modified="2015-12-09" version="1">MEEDSYLKLATILKQNHLAKKINYYLGNFEDIKNLALSNMVFYDTLKKKNFCLCLNIPYSSDDVEFESDFDKEEIVKSTIESLPWINKSLDLPISPSLITELEIPFIECIEEVSPIILSTDIQFPNLRTFTWYYNFFTSNNDLNIMVEENYKLIAHVLGGIQCSKNLKCFCFHFPQIIISGKSINNKEFYEYLIKMMTKHVSNDVRKIEFGNFEIFTKSMADYICKHFKDLSQFILYKVNIMNDVSFEDFNKLNYLYIPCFEGNIRISSNLKVLIVRCSNYEARIDYEEGDNIDFTDIEYPCNCRTVGQNFSYCINHNVGISLHRLTIYFNNPILYDFYRYNLPDKMEMYIPNFNYTGSYGTRRCYKGYYPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2X0</accession>
    <name>A0A0N5C2X0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2X0"/>
    <dbReference type="WBParaSite" id="SPAL_0001232700.1">
        <property type="protein sequence ID" value="SPAL_0001232700.1"/>
        <property type="gene ID" value="SPAL_0001232700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895303" evidence="2">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001232700.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19223" checksum="F9B6608BE24A59C9" modified="2015-12-09" version="1">MKYLITSIILAIVIFAAINGNQSSSPKSPKWKKWRGNKTFPEEIARNATYLYNNETGENYKLVKVNSTFTRVINDTDRYKVKFCATNCTKKKQPKENTKDKIKKKSYSNYETNCDQFHAVLTVKNSTGHRRLTVTKDGTNTTYNSKKVSTTTLRPVSELPKKKKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C304</accession>
    <name>A0A0N5C304_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C304"/>
    <dbReference type="STRING" id="174720.A0A0N5C304"/>
    <dbReference type="WBParaSite" id="SPAL_0001235900.1">
        <property type="protein sequence ID" value="SPAL_0001235900.1"/>
        <property type="gene ID" value="SPAL_0001235900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051381">
        <property type="entry name" value="CREB_ATF_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996">
        <property type="entry name" value="AGAP001464-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996:SF3">
        <property type="entry name" value="CREB-H TRANSCRIPTION FACTOR HOMOLOG LET-607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001235900.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47999" checksum="EC8C416DEAC71C79" modified="2015-12-09" version="1">MMNASDGTINYNGQILPTEIEDIDEPYNFNCDRPSNYLAMNNETFNDDYMHHIYTNLQEENQRDNAFENFEDNSLFNCQSFLSNSNTLSDSGVDSPSIDATLIPIPLEYEDKNFPYYTNQSSIEVLSSNNIITLYDSPKSIDEKGLNIHRNDKIRFSKNKKLVNMNGNLQKNDTANGVTSENNLNITSRGIQKISNSKSNDPKCFEYNGDSIKKVNNISASSNSYNDRSSSSGKFPPLILTEEEKKLCAKEGVHFPEYYPLTKNEEKELKRIRRKIRNKKSAQESRKRKQDYIKALEERVYEYEYENKRLKYRLECSNNENQKIILQLRKLQSVVNKDSKNNTHLSTCLAVMVLSVCFFVGHCYLSVSGNNTNRNNDNLKEIRFTGRALFLGSVLKSNLSPQPSTDADYPVPCKKFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C398</accession>
    <name>A0A0N5C398_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C398"/>
    <dbReference type="WBParaSite" id="SPAL_0001245200.1">
        <property type="protein sequence ID" value="SPAL_0001245200.1"/>
        <property type="gene ID" value="SPAL_0001245200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="154"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001245200.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="50044" checksum="45D9F16F6FC10CE8" modified="2015-12-09" version="1">MDDNKILSLFSDSSSVKDFFIENINVTLLWIVEILSNNCTEFNKAIINGTKICNFEIKQIGEGKGFISYVYRIILYLTNGETFSFILKFQTSKILNDGADVQSGEVEFISKEEVSNFHNNECLFYKLFNDIPNFRIPKVYYTQNYRINLHDGLLLLEDLTRVSNHIECYRSFNIYQIESIFDQIFILQSTSMSLKDKEWLGKLARPINDNDFLFFSQFALEHWKELTKVLPHSLYKHLEEPLEALISHWKDTIIVNCYTFKEETSNEVVLAHGDMWNNNILFKIDSNGNPTNEVEALIDWQVLHITSTGHDLAKTLIYCTDPYIRKEAEEVLLKKFFYKLKDTTSKDGTKFTMTFDLFMKNYKYAFIECTLMFLMNIGFSLKGCGMPTEDCDSVWYERKFNIGIRIIKSVADAVDYAKELKPEWLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C433</accession>
    <name>A0A0N5C433_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C433"/>
    <dbReference type="WBParaSite" id="SPAL_0001271700.1">
        <property type="protein sequence ID" value="SPAL_0001271700.1"/>
        <property type="gene ID" value="SPAL_0001271700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF819">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6 8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013770024" description="Zinc metalloproteinase" evidence="6 8">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="130"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001271700.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53525" checksum="A5BAAC1D1C0C2235" modified="2015-12-09" version="1">MTVLSQVLLALLCLHIVAGFGGLTRLRIQQETREKMSENGKKKFDQHQKAMEQLAKLSNQIHDVKPSKDDSKFDLAPMANPSMYQGDMILNKHQAEYLLNEAKMRLEAKHANKSGAEAEKEIVKKLKKNRAYKKDSPFKWKFPIPYYIDGPIPQGVVDNAFKNMERETCLTFQKSRPFNDRQGLRLFPGQGCYSYIGPISTNKPQDVSIGHGCEWNGIIQHEVSHALGLFHEQSRPDRDNYLDIALQNVAPNQRHNYDKSSIAETETFGIPYDYGSHMQYDKKSFSANGQLTMIPKNRLYLNTIGQFDKMQFNDVKLLNSIYCSNICKGGIRCSNGGYEDPKRCGTCRCPSMLGGPTCADLAKNPPECGQGDTMIATSQVKSFSIKGVKNCVFLIQAENNKKVRINIDQGYFNTTERCFPGIALQIKYNIDKTITGPTFCGTVQNQGLVSEGSQMLVNYVGTIPQHMLTFRYMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C468</accession>
    <name>A0A0N5C468_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH_dom_type_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C468"/>
    <dbReference type="STRING" id="174720.A0A0N5C468"/>
    <dbReference type="WBParaSite" id="SPAL_0001275200.1">
        <property type="protein sequence ID" value="SPAL_0001275200.1"/>
        <property type="gene ID" value="SPAL_0001275200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001275200.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25629" checksum="28CEA439976A1E8C" modified="2015-12-09" version="1">MTKVVLPGDFVEDITNLPAVPVIGRGLKVYKNEVICTQAGVLCSGKDGMFVNTNSKRYQPTVNDLVVGVVSNVMVENIKLDISYLESAVLSTLSFEGATKRNKPNIKVGDVVYARVISTSKYLETELACIDKDNFARGLGVLPYGGMVFKVSLRHARRLLSPTCQLLNLIGKEIKYESCIGMNGRVWIKAETNQVMKVIVKLIQESEKVSDADMGKFVSSYVKSMYQDVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4Z5</accession>
    <name>A0A0N5C4Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4Z5"/>
    <dbReference type="STRING" id="174720.A0A0N5C4Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0001302200.1">
        <property type="protein sequence ID" value="SPAL_0001302200.1"/>
        <property type="gene ID" value="SPAL_0001302200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="92"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001302200.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="87136" checksum="65897952511874B6" modified="2015-12-09" version="1">MPYTLENVVEEEEEGKEFLGYDENSINNSDDDSEHFNNTLNIMRQRETHNDLYDIEEFRKRYKESKHKERILLIKRKLYTLLEKPTNTLNFLYQMVIFIIIIIIHSLCAMVDIPEYSHFTTLVHSLEIIVGLYFIGEFFLRLWCVGVDAQYVGVSGRIKYMKRPICIIDIITFIVTIFLIFVDSSNLVSNKTVEKIRFLQILRLFHIDRQMATWKMMKNIVKQSRYELISVYFIASFLYLIFCFSVFITESYNEEKIILEYNENINSSSLVIPEDFSPTFKNYGDAFWFGVISFLTVGYGDIVPKYWVSKILTGVLAFCCYCMFCAGSGLVGVGLTLQLENANKVKREGKVRHLAASLIQAWYRHRLIKDDDMFEKIPRFKEQCLKITETIKRMKVAKQLVKKATASNKAKRKASKVFDYFKKKDTTENESRKNSATETSVDVGIQMVRKLGILNQVGSIQTSDQSIAEQIQNMPSLTKKFSITSSDIQPIEDNKGKVLKKSLSLVGTRPKGALQKRLSFKSCPSKKSTSFDSSQSDTNNTYESTFYPEFSDEETYIDYYYTMHEGDFQKISRGTSSLNVVDENLWKTNRILLDRLICLSFLMLKKKFKRARQPYELVDAEAELCEMEYQSNQKIKELEIRLDANIGKATKSLFAMDDEETSHSIEERLLLCEMRIKNVEKKANDILSLGETIIQMLEYKQAAESKGLIRDPVNAHLPPIPKKASKSTPTTPVKHTPTVLNKYSHLQRQNDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5C2</accession>
    <name>A0A0N5C5C2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5C2"/>
    <dbReference type="STRING" id="174720.A0A0N5C5C2"/>
    <dbReference type="WBParaSite" id="SPAL_0001315100.1">
        <property type="protein sequence ID" value="SPAL_0001315100.1"/>
        <property type="gene ID" value="SPAL_0001315100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008726">
        <property type="entry name" value="PRK11728.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001315100.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47791" checksum="7EAAF1DC7D05DFC2" modified="2015-12-09" version="1">MLLRNTIVQHKLLSSSILNQSNGIDIAVIGGGIIGSATARKLKLEKPHLKIALFEKESILAKHQTGHNSGVLHAGIYYKPGTLKAKLCVEGIDLAYKYCDEKNIPYKRVGKLIVAVEPHEIPILEDLYKRAQTNKCRNIELVSGDKIREIEPNCRGLKAIWSPYTGIVDFGVVSRQYVKDFEEVGGVVKLNHELSDVSLSSNPDYPVKLQFKNVSSPVEAKYIITACGLQSDRIAQKTGCSSVPKILPFRGEYLKLKREKSGLVRTNIYPVPDPRFPFLGVHFTPRMNGDIWLGPNAVLAYKREGYTYTDISIPDLVDALTFRGMQKLVFKYFTFGLTEMYKGIIKSAQVKQLQRFVPSLKASDVEYGPAGVRAQALNENGDLVDDFIFDGGVGKVAERVLHVRNAPSPAATSSLAIANIITEKAIEKFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5G9</accession>
    <name>A0A0N5C5G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5G9"/>
    <dbReference type="STRING" id="174720.A0A0N5C5G9"/>
    <dbReference type="WBParaSite" id="SPAL_0001319800.1">
        <property type="protein sequence ID" value="SPAL_0001319800.1"/>
        <property type="gene ID" value="SPAL_0001319800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF127">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001319800.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51892" checksum="1A5218237C3FBC07" modified="2015-12-09" version="1">MTSRNTKKTKEHKSDSEDDYFSPYINDALNEAREIVTKGKATEKIGEHILQDTTSIKVDKTRTKGKPVEVIVKRSTIATHFSDEEEDYLSSGSDGEGLFDFIGGKVRSRANSCEDIDKLLAGGEERHTKARYHKKKGSFWTKQDNKSSEKDNKNEGANLEIDVFEQTCDYVDGDWLKDNEYLLTGHRPPLPSFVECFKSILSLHTETGNIWTHLIGCVAFFVLALWFLTRPDTHIQFQEKLVFSFFFLSAILCLGASFVFHTVSCHSIPVVKLFSKLDYVGISLLIIGSFIPWIYYGFYCRSIPKVTYIAMIAVLGIIAVIVSLWDKFSEPKFRPYRALVFVLMGLSGVFPAIHFIMTDGISKMIDENGFYYLIVMALLYLIGAGLYATRTPERFFPGKCDIWFQSHQLFHLCVVCAAFTHYYGVYNMAMNRLTNVCPSDANTTLHEKHYQHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5V8</accession>
    <name>A0A0N5C5V8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5V8"/>
    <dbReference type="STRING" id="174720.A0A0N5C5V8"/>
    <dbReference type="WBParaSite" id="SPAL_0001333400.1">
        <property type="protein sequence ID" value="SPAL_0001333400.1"/>
        <property type="gene ID" value="SPAL_0001333400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333400.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28209" checksum="8C9FD489A63554B9" modified="2015-12-09" version="1">MIKYQIGECKKSYNPNDEPSNFVHVVMKKIESVDSKYSYLNSDHLEGMVLDFWGDGRQTIVTTLKWFILLVMEHIDIQKKLQDEIDEVIESDILVQLSDKAKMPYMNAFTVEGQRFANVEGLSPSRRCTKDTIINGYLIPKNALTQPLFWGTNMDEKHFKDPFTFNPDRFLDSKGSLKIENEPMTVGRGKRMCAGKSLADAELFLIFTSILQKYKFTHPCGPIDFSSDSCVLIIPRPYKCKIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5Z8</accession>
    <name>A0A0N5C5Z8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5Z8"/>
    <dbReference type="WBParaSite" id="SPAL_0001337400.1">
        <property type="protein sequence ID" value="SPAL_0001337400.1"/>
        <property type="gene ID" value="SPAL_0001337400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001337400.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="74836" checksum="C057731EB679772D" modified="2015-12-09" version="1">MNKLNSNVECQFCGRKIERSGYLDHLKDMHEYTDDKFLKKIVCPLPEYSCINGIKNDAKSEKLSNVIDHVICQLLKDHKHTDQFVFDIASALQTIFSATGDATLIKALSNTQFLNLKKRSKMFVKKLVGNVDSSFSDDSDSEDTENVHVLENNLDKAFSTDLCMDVANHLKTIDYASKENDNKLKVVVYFDDIGINNPLSSHRSNGMITHCGYSILNTNKESSKLNTLRTFAVSPTALLKSDRYESFFKETLKKFKEAKIAHKDKVYDLEIFSVIGDHPILQDLFKRKKNFGNRGYDQCRGCTIPASLYNKYLECKKVEEMVRLDHDIEMVPEWNHIISDSFHDISEGKYIILSYSYPDMGKISLRILGNMLYSAINNFLIVTRYSHTELKNDILAMSSEYECLKTLKSVLKDDFFKLSSEKKHIMKKGRFPLTGSQTNVLARMFYEVLKKFICSNEEINNFDSNIILKLRQHLYILKCILNLLYLMESFEFDNNSLEKMVEETVDNFFKILFVTYGENMKLSMKYHFILHYPLMIKKFGLPVHLSCKRFESLNKYVKDKMLLNCCKTNIGLSIIRKIVYDNFLKSLIHEDTISDPISLIRKTWDFNCSLDESLMECSTLEHVLEYEILNLNMQLNESIVNENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C771</accession>
    <name>A0A0N5C771_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C771"/>
    <dbReference type="STRING" id="174720.A0A0N5C771"/>
    <dbReference type="WBParaSite" id="SPAL_0001378500.1">
        <property type="protein sequence ID" value="SPAL_0001378500.1"/>
        <property type="gene ID" value="SPAL_0001378500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001378500.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26328" checksum="6B1FC5254CEB7E5D" modified="2015-12-09" version="1">MPELSIVHAEESQAPIISSVDSTQHLEIETAALKEGLELLRSLEREPTGLPPYMTTNVERCKESINKIFKTTFNLIQARRAGTITTDEHSRTKILLLKDAGQTLKRYLIVYHHERLNRIRKITRNTCGILGQSLKANMSKNEQTFAEKYYRLYIDFENDVTSNNGLKLLTNNSPPKLEYYYYRCKEDYGEYELADGNIIIIKRGLIHHMPKENAETLLRSGIVEQVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7M3</accession>
    <name>A0A0N5C7M3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7M3"/>
    <dbReference type="STRING" id="174720.A0A0N5C7M3"/>
    <dbReference type="WBParaSite" id="SPAL_0001393500.1">
        <property type="protein sequence ID" value="SPAL_0001393500.1"/>
        <property type="gene ID" value="SPAL_0001393500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000039">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000034">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="135"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="351"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001393500.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71092" checksum="FDF3C73F0507AE58" modified="2015-12-09" version="1">MIISYLARLVLILPEISSEDANRLKMIADKHIEMTGNKDIDLNYFGNKNNDFNSLAMTNLPDKSFTNYGIHHTNKYEMKFKNINNQKNIQISKNPPWTQVVESNSIQEKINDLNENIIKSKFSDPCIPMNETLRKDLIKKLFDESYDKNTLPSTNSTPVIVELTVQSITEISEFSSSFSGDIWFSQIWKDIRLEYGSNNYCLTNLSLSAHNLQHLWTPNVCFINTKRVEIHASPSQNVLLLLFPNGTLWLNYRVSLTGVCRIDLKYFPFDFQECSLIFESYSYNTAEVRIVWREWDPVTIPDPNAKKLPDFELVSFNHKKDTLVYTAGLWDQLEVIFVFKRLYGYYVLQAYLPTYLSVFISWIAFWIDTKALPARITLGVSSLMALTFQFGNIMKNLPRVSYVKALDIWMFGCVGFIFLSLVELAVVGFADKLEAKKRRTRKARQMLLTRSDSEQQWLARFNNHPIHVNLPSSHNITLQSPCMNTNDIYSGSSPSDDYFQENNNYQNQSAGESPNITLRSNNFPQRNTTHITSDCRENINKSPCCTQNCAWDVLTRSSKNGSQKKQHITVVQKKTRKISGEQIDAISAKLFPLLFTAFNIFYWFYYIGMSTGVTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8P5</accession>
    <name>A0A0N5C8P5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8P5"/>
    <dbReference type="WBParaSite" id="SPAL_0001428500.1">
        <property type="protein sequence ID" value="SPAL_0001428500.1"/>
        <property type="gene ID" value="SPAL_0001428500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001428500.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16417" checksum="CC1B35652129F040" modified="2015-12-09" version="1">MLKIHISIIFIIVCVLIFIFINAYNKYFNDILKENGDSCCVELDILNYSRVEPPYRSFSYGWSQESKLRNYVDSTCPLNGVFVCAKDLKKLSNYTHIQFLSSNGKIIYENSDESNVSIWVRCLNKNWLVEGKSFSAITCSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAP5</accession>
    <name>A0A0N5CAP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAP5"/>
    <dbReference type="WBParaSite" id="SPAL_0001496500.1">
        <property type="protein sequence ID" value="SPAL_0001496500.1"/>
        <property type="gene ID" value="SPAL_0001496500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895616" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001496500.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="17958" checksum="F685DDCF5C827251" modified="2015-12-09" version="1">MMVLIYFFILLLNCFTTIYSQELSSNTTEVALYRKDKDGEKNVVIRAKRQCGFGGCGMGMNMGMMMPPMAMMGGCCPPPMPICCPPPMPAPVPVPVPVPVPIPTMTGGCCSCCVPVCTPMCIRTCGMGMGMSMGMSYGGCGGFGGFRRAKRSTMLQLGHIKGPEIDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBD4</accession>
    <name>A0A0N5CBD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CBD4"/>
    <dbReference type="WBParaSite" id="SPAL_0001519800.1">
        <property type="protein sequence ID" value="SPAL_0001519800.1"/>
        <property type="gene ID" value="SPAL_0001519800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001519800.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52367" checksum="D84245A203536CDD" modified="2015-12-09" version="1">XSRNYYSTLDLSDAFWNIGIEKESRDLTTIVTPWSCYRFKRLPQGLKVSPLIFQCYLESQLNPDMLEEIVIYQDDIIIITDTLERNRQLVFDIMTKLESLNLRLSKDKLLLFKKEVKFLGCWISAKGRKICTERYNHFKALKFPETLKDLETFQGLLSYFASYLVGLYKFKECFELEKVKVENNKIIPTTMQLECFAEIIKQLSSDNAVVHYSLKEKLLLACDSSDNIMGATLFHVYSDNSRKPIISACKTLTSFEKKYDIASKEALAIVYFVQRFNQYLRCRKFEIECDNRAVTCIFQNNKNISKLAAKRIARYRLILSHYDFSIKLIRSKDNVLPDALSRLIDMDKVELFKEEEVLVSALSDSNYKNEFMLLKEELPSSVNISELIFISNEDEVVNKVKGILSGNGNWDKKSRNLEEQFLLKNRFNLDVLDNILLVKQIICWYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBH2</accession>
    <name>A0A0N5CBH2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBH2"/>
    <dbReference type="STRING" id="174720.A0A0N5CBH2"/>
    <dbReference type="WBParaSite" id="SPAL_0001523800.1">
        <property type="protein sequence ID" value="SPAL_0001523800.1"/>
        <property type="gene ID" value="SPAL_0001523800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="268"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001523800.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50005" checksum="726E83D78E8CCF20" modified="2015-12-09" version="1">MEDENEIEKDIPREEISLLNKILNSRLEELKKGTVEVLSQQQNPDSPLYSADSFYSLRLKKELLDRLPEINYLMPSNIQGTALPLLLQEPASDLIAQSQSGTGKTATFVLTMLHKIDISVMEPQCICMAPTLELAKQIGEVVSSLGKKMEGLEIFYAIKDNHPTESIKSHIVIGTPGTVYKLITKVPIRLNHSNIKCFVLDEADVMVSTQGYQTMSVLIHKKILSQSPKVQTMLFSATFEENVKKLATALVPNAIILSIKKELLALDNIKQYYVKCDSREYKYMALCNLYGALTIASTIIFTHTKASSDWITYKLEEKGRKVLRLHGNLTSQQRINTVKDFRDEKARVLVTTNVAARGLDFPQVTLVINYDLPLDSKGDPDFDVYYHRIGRTGRFGKFGIAINFIDSQRSMDQMLTIQKYFNKEIIPLDPENFEEVEAIQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBI2</accession>
    <name>A0A0N5CBI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBI2"/>
    <dbReference type="STRING" id="174720.A0A0N5CBI2"/>
    <dbReference type="WBParaSite" id="SPAL_0001524800.1">
        <property type="protein sequence ID" value="SPAL_0001524800.1"/>
        <property type="gene ID" value="SPAL_0001524800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="182"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001524800.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41556" checksum="842E6166521356CD" modified="2015-12-09" version="1">MSEELQYSGVNFFRQRLVYSLLSGRSVKIIDIRYKNESPGVKDFETSLLKLLDQITNGIKVTINQTGTVVHFQPGVLIGGNVSFDCGTSRCISYFLEVLVVLAPFCKRPINAKLNGVTNKHDELSCDAIRATWLPIFKKFILNDENLEIKVLKRGFYPLGGGFVTFKSPVTKNLRPITIEKVGKVCKIRGLAYTCRVNSSFANRMVDAAKEHLRNFIADVYITIDQRKGEAGGKSNGYGIFLTAETTDGVFYHGEAMSREAIDGETPLVPEDLGKAAAEKLLDEIYRGGASDCTASFLVSTFMALTDRNASKFMYGSLTQYSVYGLRHLKDFFGITFNLSQRKKENEETQDGCKEKLIGSCIGVGYTNLNRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBJ1</accession>
    <name>A0A0N5CBJ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5CBJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001525700.1">
        <property type="protein sequence ID" value="SPAL_0001525700.1"/>
        <property type="gene ID" value="SPAL_0001525700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001525700.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13294" checksum="4277CA0264269DC0" modified="2015-12-09" version="1">MAKSTVQKCEMSQEQLNAIEEEEFKIGPLSILTNAVRQNTQVLINCRNNKKLLGRVKAFDRHFNMILEDVRELWTETPKTGKGKKKGQAIAKDRFISKMFLRGDSVILVLKNPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCA5</accession>
    <name>A0A0N5CCA5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable ATP-dependent RNA helicase DDX23</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAD box protein 23</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCA5"/>
    <dbReference type="STRING" id="174720.A0A0N5CCA5"/>
    <dbReference type="WBParaSite" id="SPAL_0001551400.1">
        <property type="protein sequence ID" value="SPAL_0001551400.1"/>
        <property type="gene ID" value="SPAL_0001551400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000520">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="302"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="518"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001551400.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="80445" checksum="EF6497E55B378A14" modified="2015-12-09" version="1">MSYGNKSKGLISLGDLLATKKAQEEEGVKPKFLTKAERQALAIKARQEEAARLQAQRKEFEEKRKEFMKESEKASDKRDRRRDEDKERRKNYEDRGESGTGSSSRRSKDDGTLSSSKSKKMDEEERMQYEELIRSRYLGKDKEKKKRRRKLHGRNFNFDWEETDDTSKDYDKLYKERHEIQFFGRGHIAGMDPNELERDKKDYYQHVKEERKDKFDKLLDEVKPKKMRKDEWEDVHWRKKPLEAMSERDWRIFREDFNITVKGGSIPKPIRNWNETPIPKQILDIIHKVGYKEPTPIQRQAIPIGLSNRDIIGVAETGSGKTAAFLIPLLVWITTIPKKETTDILDGNGPYAVILAPTRELAQQIEQEAIKFGQHLGTKTVSVIGGASKEDQALKVRMGVDIVIATPGRLIDTLDNSYISLNMCSYLILDEADRMLDLGFEPEVNKILEYMPVSNMKPDSEEAENESSLLANFMTKNKYRQTVMFTATMSPAIERLARQYLRRPAIVYVGSIGRPTERIEQIVYMISEEQKRKKIIEVLTKYYEPPIIIFVNQKKGADILAKSLLSMGFNPAVLHGGKGQDARESSLAALKENKKDILVATDVAGRGIDIKDVALVLNYDMAKSIEDYTHRIGRTGRAGKKGRAVTFLTPEDKDVYYDLKQCLIESPVSVCPPELANHPDAQTKPGAIVTKRRQDETVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCY0</accession>
    <name>A0A0N5CCY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major capsid protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCY0"/>
    <dbReference type="STRING" id="174720.A0A0N5CCY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001572800.1">
        <property type="protein sequence ID" value="SPAL_0001572800.1"/>
        <property type="gene ID" value="SPAL_0001572800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001572800.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31834" checksum="8FE42412463998B4" modified="2015-12-09" version="1">MAEEPDNNEILGLFDNSTQQPAEESADDQLINALLHNKKSMTLSEQGMKAVSKIFSCKRISHETIESITDRMGVHQDLQFLAPAFSTPYYSKLKMRSVDSNLAKMQDHLLQSVCMLSHNVEAATGDNKSAVLSALINIKYVVDGLSDIRREVAFRNFSPKFNKGLPSVPLDMEEKVTRMDSSERISILPKHAEALFKNVADTPQDLLSFIQRENRKRSYNNTANIEPERYVIINPNMPPNTIHQCLPFWQKIAPTDTVLLDYIINGVDIGILCEPTQHKIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE30</accession>
    <name>A0A0N5CE30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE30"/>
    <dbReference type="STRING" id="174720.A0A0N5CE30"/>
    <dbReference type="WBParaSite" id="SPAL_0001612100.1">
        <property type="protein sequence ID" value="SPAL_0001612100.1"/>
        <property type="gene ID" value="SPAL_0001612100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001612100.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="68220" checksum="E126DC4ACE690347" modified="2015-12-09" version="1">MKYKKCKKINDNIYYKFVDEVITVTRKDFYCFYSCIYPKEGFKIAFSRYVYIDKSSKLDCDIFHIRCFNISNAVVYEDVHFHVKKLSKIPKESTNFLKEDFSIPINNKRYDVHIYVIDSLSYYHALRALPKTRKFLKEKFNGVEMEYLNVIGPNSRINAYGFLLNKQNLDVYDFYYNNKTKKNDFGNLDSCKIYLDNKTFIQEYYRRMGYVTLDAEDSEYDVIFTYIYCAGFKNEPTHHSLKPFQALWSNLITRKILKTKFKKQCYHHGFHIMNYMSDFLEKYKNDLKMSLMWQTNVVHDNLNEIFAADEIYYKFFEKNEKYFKNSFTILIGDHGNNMNKLIKYDIGKYEQKNPYFIITIPEELRSNEQLVKNLKENSKKHISHFDIYATLLDILTNAPKDEFKMLDKQKKFPIKNDIIKGLSLLRPLPVYNRNCYEMSVPLQYCLCRPHFEPLPSFMVMERSKLEMNFIKALNNKLVEGNLTDKCAEMSLDKSEEFIIKFAKGGNSKMVYQVDAVTMPGKARYRAMMTHNFEVMNNEILRLNIFKHQAEVCEKFSFHRIYCYCKILLHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEL1</accession>
    <name>A0A0N5CEL1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DnaJ homolog subfamily C member 21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEL1"/>
    <dbReference type="STRING" id="174720.A0A0N5CEL1"/>
    <dbReference type="WBParaSite" id="SPAL_0001629900.2">
        <property type="protein sequence ID" value="SPAL_0001629900.2"/>
        <property type="gene ID" value="SPAL_0001629900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="17">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001629900.2"/>
        </source>
    </evidence>
    <sequence length="482" mass="53078" checksum="C1CA8713D05FE726" modified="2015-12-09" version="1">MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGVVLDSGDGVTHTVPIYEGYALPHAILRIDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEAMFQPSFLGMESAGIHESTYNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSISNGFVLGALALAAIGYGGRFILRNQRAIKKAAEALPGANDAFSKYYKGGFESKMTRREAALILGVQPSAKPKVIKEAHKRIMIANHPDRGGSPYMAAKINEAKDLLESKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFU2</accession>
    <name>A0A0N5CFU2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFU2"/>
    <dbReference type="STRING" id="174720.A0A0N5CFU2"/>
    <dbReference type="WBParaSite" id="SPAL_0001672500.1">
        <property type="protein sequence ID" value="SPAL_0001672500.1"/>
        <property type="gene ID" value="SPAL_0001672500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 8 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="112"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001672500.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33941" checksum="F01D47553773885A" modified="2015-12-09" version="1">MLSRVTRLRPLFKNSICGSVSFSNKKDDKDIEIDTTKLQEELKKIKIDYKDVDPEFMNFKQQNERQKHERSFIFGWKTSLATLGVGSILVAILLYMRQQRLNEEEKRRKIMAGKARIGGEWELVNTDGKLEGSKDLLGKWVLIYFGFTHCPDICPDEIEKMISVVDQLSKTNPEIPIVPVFISIDPTRDTKERVKAYCQEFSPKLRGYTGTVEQVKKVAKTFRVYHSQGPKTAEDDYIVDHTVIMYLIDPNGEFYDYYGQNKTDEEIVNIIKMKVLKYDIAKKKEGKLFDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGA1</accession>
    <name>A0A0N5CGA1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Small nuclear RNA-activating complex polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGA1"/>
    <dbReference type="STRING" id="174720.A0A0N5CGA1"/>
    <dbReference type="WBParaSite" id="SPAL_0001688000.1">
        <property type="protein sequence ID" value="SPAL_0001688000.1"/>
        <property type="gene ID" value="SPAL_0001688000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001688000.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58784" checksum="65F8D438511C5943" modified="2015-12-09" version="1">MSLDSLIGNRRLFKFSPILNLNDFRYNAIHVKNSLKLSFPCANEENLNGTQFILGESTPRSCHGNIETVEDHDDQRKENNTPSDVVTDDGKSSTAFDYDVRVGNSSTCQVAANKLLKLTFEKAPPGEIETKYKERLLKPGEEVLDDVAIDYNKPIINESSMAKYKNGFLNLINSWNSNLSAAEAATYNVEFFGTECIKKTPVYSTIHLFGGVVEYKDKFSHRISVKKMKAFRKNRNLKTVYSSKTKYFNFEEFSYDTRTNDLNVEIPNEIRLTVRIYMPKVRRDIRLPYNFNAGYPVIDKTFFFCGDNTLKQLKDEMLCYWDLVCVKKEEEGIPNYKDFMMYKVPSSFIFIHDTFYIDKSKPHLADITEEYREFMEKRPHLYGSTKTADMESTKLVDLNLRLGMAYVYVHMGGRCEHMFSISDVRMITYNDYHNINTYPIKVNHPLRKRSCRVCGNVGSRYIIAECESMPKTPKLMCESCYKTFNYTLSIKNSDSVVYPYVDRNLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGR6</accession>
    <name>A0A0N5CGR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGR6"/>
    <dbReference type="STRING" id="174720.A0A0N5CGR6"/>
    <dbReference type="WBParaSite" id="SPAL_0001704100.1">
        <property type="protein sequence ID" value="SPAL_0001704100.1"/>
        <property type="gene ID" value="SPAL_0001704100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20188">
        <property type="entry name" value="T-box_TBX2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000016">
        <property type="entry name" value="T-box transcription factor TBX2-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="78"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001704100.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58024" checksum="31CD0FD70595B0AC" modified="2015-12-09" version="1">MSFTPFFQRPDVAFLNPYLNGPQQHLPYPNLPGHGNFFPHLGMDSVTAAALASITAGPPVPPMIMEDDGVQDDPKVELDDKDLWDQFSSCGTEMVITKSGRRIFPAFKVNISGLDKNAKYFLLMDIVPADECRYKFHTSRWMVAGKADPEMPKRMYIHPDSPATGEHWMSKGANFHKLKLTNNISDKHGYTILNSMHKYQPRLHVVRCNDIAHLPYSKFKTFIFKETEFIAVTAYQNEKVTQLKIDHNPFAKGFRDAGAGKREKKRLMCRGDVSSSSINSKESSPLLKRNTSIQNTSGNRSDSRHSCENNTFEKGAESEASEDDSGIPLKRSKSSCSTSTLDTSTNSSGPDEKPISSTENRAPSSLSHTPSNNGDIKPISTPTITTSKGFLPPMSMSFKEDLQLPFMFPPTGPFHGFSQSAAFFAAAAAAAAHQNNPLNGLNPMMGGLPPNFLMQNLILQQQQNLLRMANPTIMQATSAAISPLLASSPPEESAAAVPPTKNENRTPSPNQPISKKSGFDMNDLLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH25</accession>
    <name>A0A0N5CH25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH25"/>
    <dbReference type="WBParaSite" id="SPAL_0001714900.1">
        <property type="protein sequence ID" value="SPAL_0001714900.1"/>
        <property type="gene ID" value="SPAL_0001714900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895928" evidence="2">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001714900.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46547" checksum="32756E69AE5180E6" modified="2015-12-09" version="1">MFVGLFLFPFVTFIILTLVDSTDYISKHDVINWIDESKEKNYGIDKQVEKILKRNDIGIGAFKIKRDTFSAINTTSTTPIIKNASIKVIEHNATLDSNLNVKLKAITSNKRKNRFNMIKLIQRKPAGKRRQTTKRKNKSKRRQTTKRKQATKYRTTPKKKLTTKRKTTSKKKLTTKRITTPKRKLNTKPKRKLTTKRRTTPKTTPKRKLTTKHITTSKKKSTTKRRTTPNKILTTTTVKTTTSSKKPSSGNEIDSLRRKYLDQTNKYRRLHGSPDLTNSQKLENLAQAYAEKLANEFSGQLIHDPDQTYGENLAYMPSTMIDDPVKLWYDEVKNYDFNNPGFGMNTGHFTQLVWKNTKEMGCGIGRINQKNNGFYYYIISCKYNPPGNYPNQFNENVLPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHA2</accession>
    <name>A0A0N5CHA2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHA2"/>
    <dbReference type="WBParaSite" id="SPAL_0001722100.1">
        <property type="protein sequence ID" value="SPAL_0001722100.1"/>
        <property type="gene ID" value="SPAL_0001722100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001722100.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="49698" checksum="04E6537493B1ED91" modified="2015-12-09" version="1">MKTGLPEANLEIPSTDIADVANNVASNNAINAADYNGNDKKVHSLRINKNVSTANAAKNPNTSEVANSATEIKCIQDVNIINNSVCKGLDFTKKVDSAKMQKIIKDSNQAKIQELVRNLSNTNVSKLAKDDTCSKSQNDSKNLEDDTVSKEKKRRCPSEWAGPIPKISRGSYKHHSSTSSPAVKIYNTIQLRVVEALISSKLSLDDFITILEKNTRTIEAQLFMEQLRHFIHAVDGGKWREEVFQARLRNQVLAKSAVIHYGSIGCTKELENIYDAIHATASGGMAMSIIGTRPIMLPSHNIPKWNGMLFCTRKVGFTANGIQFDTLLARSTKLRVVVVNTCKLMGKMLHAVSKVSTIQALVCKQRVYLVPEGQNSNLFWKRHKRASVKVLREMAVDVGSGNRLTLLGHVYFKSMEVLSYICNTAAPASKMAEAKAKRELTINQMKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHE7</accession>
    <name>A0A0N5CHE7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHE7"/>
    <dbReference type="WBParaSite" id="SPAL_0001726400.1">
        <property type="protein sequence ID" value="SPAL_0001726400.1"/>
        <property type="gene ID" value="SPAL_0001726400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001726400.1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7405" checksum="AE6CC24AA6E964F7" modified="2015-12-09" version="1">MDMEVDGEDFHWRKRFEKCIANPDSRGEISELVVDLEKLALDMAKKKITMDPHIFIQWVIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHM7</accession>
    <name>A0A0N5CHM7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHM7"/>
    <dbReference type="STRING" id="174720.A0A0N5CHM7"/>
    <dbReference type="WBParaSite" id="SPAL_0001734100.1">
        <property type="protein sequence ID" value="SPAL_0001734100.1"/>
        <property type="gene ID" value="SPAL_0001734100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000199">
        <property type="entry name" value="Glycine dehydrogenase [decarboxylating], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="795"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001734100.1"/>
        </source>
    </evidence>
    <sequence length="973" mass="107923" checksum="153868370B9217C2" modified="2015-12-09" version="1">MLRLSCKKITSPSNFVRLIQAKYFNNDIFAERHIGPSELEKQKMLDYIGYKDLDALTQANVPDSIKIKKQLNLPEPVNEQSMLKELREISGQNKIYRTYIGMGYHDCIVPATIMRNMLQNAGWTTPYTPYQPELSQGRLEGLLNFQTMITDLTGLEIANASLLDEATACSEAMALACRATKRNVLLYDPNLHPQNIDLLKTRAKHLGYTLKPIDFDNYNVTSEVGGVMYQYPDTNGNIRNLSDMIQRNKEAGSLSIMVCDIMALTLMTPPGDMGAEIAVGSAQRFGTPLGYGGPHAGFMSCVKNMGKVPLSRMMPGRIVGVSKDVHGNKALRLALQTREQHIRRDKATSNICTAQALPANLAAMYAVYHGPNRLQAIARKIHKSAAFLQQQLKQAGYTTINKSYFDTIKISGINIEEVKKRCEEKKVNLRYFDDNSVGISLNETVQEEDIVDLLYIFDVPVPEGNISQMIHETAAPLIGNSEHKRTSLYLTNPVFNTYHSEMAVTRYMKKLENKDLSLVHSMIPLGSCTMKLNAAAEMLPLTWPTLSNIHPFVPIEQANGYQKIFNDLEKWLCEVTGYDNFSLQPNSGANGEYAGLLAIKGYLKSIGQENRKICLIPTSAHGTNPASASMANFKVVPVDSDKHGNINYKDLSLKAEKYGSDLGAIMVTYPSTHGVFESNIIDVCNKVHENGGQVYLDGANFNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKSHLAPFLPGHPVISPNGNVDGSVSGTPWGSASILSITWAYIRMMGGKGLKEATQVAILNANYMAKRLEEGYKIVYKDEQGLNAHEFIIDCSPFKKTAGVEVIDIAKRLMDYGFHSPTMAWPVHDCLMIEPTESENKDEMDRLVDSLLSIRQEIQNITDGVWDKTNNPLKNAPHTMTAVTSTNWNKSYSRELAAFPKEWCYHKSWPTVGRIDDQYGDKNLICSCPPMDSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIT6</accession>
    <name>A0A0N5CIT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotran_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIT6"/>
    <dbReference type="STRING" id="174720.A0A0N5CIT6"/>
    <dbReference type="WBParaSite" id="SPAL_0001774100.1">
        <property type="protein sequence ID" value="SPAL_0001774100.1"/>
        <property type="gene ID" value="SPAL_0001774100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001774100.1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6490" checksum="3D80C4E55A158E0A" modified="2015-12-09" version="1">MSCNNNLKRVYLDAAGAGIPSEWLLNEIKKIDLSLFSNPHSQSNTSKDTEARISQIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CJ07</accession>
    <name>A0A0N5CJ07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PI3K/PI4K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CJ07"/>
    <dbReference type="WBParaSite" id="SPAL_0001781700.1">
        <property type="protein sequence ID" value="SPAL_0001781700.1"/>
        <property type="gene ID" value="SPAL_0001781700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001781700.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19582" checksum="4A85D5CC910A07C3" modified="2015-12-09" version="1">MSNLNDSLDESSKFKLIQLRELLKRIDDALPLNNQQLLRYTGVLDRREKQQLPVLRGLLKGDLLLNSTSTFRSSVSSIDKLTLSPIKPNIITILPNQSSATISNKPKTMSYHFTLAVTKFSHTETSRKFSTFLSQLRDAFAIDGVTDENTKFPLLRSRFEDKAREMLPNKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H6ABW9</accession>
    <name>H6ABW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 7">Ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="Exp. Parasitol." volume="132" first="62" last="68">
            <title>Strongyloides papillosus: changes in transcript levels of lysozyme and aspartic protease 2 in percutaneously migrated larvae.</title>
            <authorList>
                <person name="Biewener V."/>
                <person name="Welz C."/>
                <person name="Khumpool G."/>
                <person name="Kuttler U."/>
                <person name="Schnieder T."/>
            </authorList>
            <dbReference type="PubMed" id="22366363"/>
            <dbReference type="DOI" id="10.1016/j.exppara.2012.02.009"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="JF326457">
        <property type="protein sequence ID" value="AEZ67031.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6ABW9"/>
    <dbReference type="STRING" id="174720.H6ABW9"/>
    <dbReference type="WBParaSite" id="SPAL_0001407200.1">
        <property type="protein sequence ID" value="SPAL_0001407200.1"/>
        <property type="gene ID" value="SPAL_0001407200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEZ67031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001407200.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10234" checksum="0C96885CA5442F1D" modified="2012-04-18" version="1">MAKRTKKVGITGKYGTRYGASLRKQVKKMEVTQHSKYTCLFCGKEAMKRTCVGIWKCSKCTRTVAGGAYVYSTVTAATVRSTIRRLRETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B247</accession>
    <name>A0A0N5B247_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B247"/>
    <dbReference type="WBParaSite" id="SPAL_0000015000.1">
        <property type="protein sequence ID" value="SPAL_0000015000.1"/>
        <property type="gene ID" value="SPAL_0000015000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000015000.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="42818" checksum="8CEDB0E0BF4D6A98" modified="2015-12-09" version="1">MLLVGIIYTYHLEKIKTDGLVEHDLNHENGALINNNLNALSSQNFQEESKSDIAVREKRQAQQRRSRRRRGQRAQRRQREQRMRRLRQQRQRRLRQARRRQAIQRRRQQAMRRRRQQVMRRRRQQEMRRRRQQVMRRRQQVMRRRKQQAELRRREEQRRRFSRTTVRPRLPSRRVTMGRPRTTPGRSGKESGGRRPSDRGSGSSRPRQHEPSEDEEDAEGKKDAEDKEDAHGKENSGEVEEEPEDKEEEEEEYDYEEKNDGESEDRLSPPEEENNEQSENEDGDVEKEREENEDEEEKEENEEEEEEEGNGEEEKEEEKEKGDEEEEGEEDDDDDEEDDDEEEDEEEEALSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B298</accession>
    <name>A0A0N5B298_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B298"/>
    <dbReference type="WBParaSite" id="SPAL_0000020000.1">
        <property type="protein sequence ID" value="SPAL_0000020000.1"/>
        <property type="gene ID" value="SPAL_0000020000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000020000.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39758" checksum="FA4ACB4258B69D6B" modified="2015-12-09" version="1">MKTIISIVITTILLATNIYSLIRCPDFKKVKRSSRFQPMSVMCDTIAQEKYAESYVYYIKANFTTETCTYSPLTKAFISPKVIIAADSKIIYRRGPESHTIRPPCLPERAEYLTGDVYLLIERIPHPTDDMFELEESFKDAACTNFLNEAANINSGNSTYEEKLKFIRRVTAYDGLIGDIKDGRIHWVKCDIIDLPVANKTILQSDCFYGAMIETYNGNFWYSRNGLDIDDKEEVEQCIYSHSLIIKRSISFNNGSEETKSTYLDDCYNGSLSTRLFKFCFFGRKLAIIHEALLELTSAQLATIVIILSVIIIFMMCCFCCAVESLHSNANKRHGQRIRRHGSHVSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2R6</accession>
    <name>A0A0N5B2R6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000036900.1">
        <property type="protein sequence ID" value="SPAL_0000036900.1"/>
        <property type="gene ID" value="SPAL_0000036900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000036900.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21492" checksum="4CA077F3A4D4FAD5" modified="2015-12-09" version="1">XTNFIFGCLSNIVAISLVVKKRNESQNKYYTLMLFLQFGMAIISVIGNRYLKPHIYVFDDFLIAFSRPLSDSPSSDFLHTSLFGFSVFLLYFNITIPTGLIASRFYIVCTNSGFKRNTIIRVLGLCTTLTIIQAVGITFPFSEQASSDIKIDAIKKYNIESDILTESTAVLGRKIVRFFTINFFNANFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W5</accession>
    <name>A0A0N5B2W5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2W5"/>
    <dbReference type="WBParaSite" id="SPAL_0000041700.1">
        <property type="protein sequence ID" value="SPAL_0000041700.1"/>
        <property type="gene ID" value="SPAL_0000041700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000041700.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49504" checksum="B96A28E9129FE1CC" modified="2015-12-09" version="1">MEDIDLEKLKKEELVKLLQEQGRKARPKVNEVFDALMNFKFWPTTNSLAVMDVIFLSQSIVEVLLKQFGDLTVTAVEDVDEYLEKTYTPKVAVTTKIMELLRFCKHEHESIPIFHASCIAKVESFEALCSSHNVVEVCLQIAGCYSSDRLREKALAYFEEKLTNKATVVISEFTEKMEFHASLFTDESVNVVKSLYKKKRHKKKKAKSFNAISSNTDSVIVSVNSAEVDYVNKDLRYCTIRVASSFIRFKIILNKPKMSQTSIQARKCNGRIFQLLGYFEEVIFGHTVKIYVADVLSNFEEVIFGRTVKIYVADVLSNLLGGISAYRAVASRLKRIKEISHVGTEISEESLRHELMEKFPVLTGVKSSSLGISGFIADSEFLPGVTPKYIPARKVPLGFEDIVNNLLNEWIESGIIESLGDMIPSCASPLMLAREENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B305</accession>
    <name>A0A0N5B305_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B305"/>
    <dbReference type="STRING" id="174720.A0A0N5B305"/>
    <dbReference type="WBParaSite" id="SPAL_0000045600.1">
        <property type="protein sequence ID" value="SPAL_0000045600.1"/>
        <property type="gene ID" value="SPAL_0000045600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="67"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="401"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="710"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000045600.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="101901" checksum="DD11804C93536EF6" modified="2015-12-09" version="1">MLLLSNSKRISLLHSRYTSSYLKWPLNGPNELSANLKNLENHWKTISETRIKPTDPFAPTKYVLSMFPYPSGALHMGHMRVYTISDVLARYYSLQGYSIIHPMGWDAFGLPAENAAIERGVDPSKWTYDNIDFMRGQLQKTGIIFDWDREIFTCDPSFYKWTQWIFLKLSEKGLVKRAVSEVNWDPIDKTVLAAEQIDSEGRSWRSGAIAEKKKLRQWIVETTKYAKRLKDGLDLIREDWKDVADIQSNWIGICDVYKFNLPLRDENDVVLDETLDLRIKNPYDIEKGQFIVIGKNHQLVKDYGKETNDKYYILNGVKTMNVITGKELRIIVENIDGEETGSKEMFLNARLGGEMLSKEDKEISQILNLPLPPVRVRNLPLVDIQEIAAFGGYGGYITSRKLQDWVVSRQRKWGTPIPMFLSRENEKDIKRVPYESLPVTGADRGIEETIDGRRWVFENDTLDTFFDSSWYYLRFLDVKNDYFPVAYDKTVKSMPVDVYVGGIEHAAVHMFFARFISYFLKDIGVVSCEEPFRNLVPQGIVRGRTFINPKNGEYIRKENVITKDGKFYDKSSNAELENVFEKMSKSKHNGTDPIDVLDNYGIDLTRLQLLVAAAPKSPINWDVEDAKGIKRWLDRIASLVNSYIEARKNGTLFDIEKVDKKKEKELKDIYNYHIRNATISLEDLHLHNTALAKIIALINTLKKVDPKYIEYSPEFERCLYSIVIMLQVFAPHTSQELWSALSQVPALNQNKWDKSKDVRGQRWPEIDNDTVIDVFINACDINCVKAFVPRLEIEKLTDEDIYERTKSHWHAELFSEFEKNGHKIKGYHLKRKDGRFCIINLDFESNTTERDVRMILNDIVKKRSAAAKEAKSKNKKSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3D5</accession>
    <name>A0A0N5B3D5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3D5"/>
    <dbReference type="WBParaSite" id="SPAL_0000058600.1">
        <property type="protein sequence ID" value="SPAL_0000058600.1"/>
        <property type="gene ID" value="SPAL_0000058600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000058600.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="45180" checksum="0DF47E1FDC939A28" modified="2015-12-09" version="1">MNNIIKSRFQNKNIRNAITSTIENIGKFNETNVIMFDTHDFEFPLEIINKGAQQVTIVEGSKKYHRWQVNSLDKWKLNNNAIEDKNFLNTDRNFPSIILASKCVLNANVEEIFNTTKRGKQNSETFVEQILQYNSNDYIQKYPDKAHEVKKDEKIAYSKNSVIITATNTTRSHKHFINYLMNEAGTYYSNKESSLLSPKTKLSLITFITPELYYELFLVKNNLMSPSKTIIKNSLFFNTFFNLKDIGSFKCDEIYPKMILPEYKATTLSKLEDNSIDPSLMKGILIQPKSRNELGYDQKHIDEIFIVKLHFLLSKIVNIRKRDTFEGVFKSMFTSYPGDINLSSKFWSIPLNEILKLLPKLFNEEFTQEMKEEFENFQISYKKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3W7</accession>
    <name>A0A0N5B3W7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3W7"/>
    <dbReference type="WBParaSite" id="SPAL_0000076700.1">
        <property type="protein sequence ID" value="SPAL_0000076700.1"/>
        <property type="gene ID" value="SPAL_0000076700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000076700.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="62615" checksum="1C9FFF034E5C061E" modified="2015-12-09" version="1">MDTSSSEEDLPDGTHANVNTRSENVTSDEIRNTTTPSTGRPCTRSYLRKRKATKSTDARSPELSSVSELTTTSHSNPATTDILRQWQNPTNTCGYNVDSSDGIDLRGKVPLTNKNFNFDAILFKDLGISKDKEEQNHIHASDLISEQIQSIDPSDDEEQISHIINSLQILHTTDLSTTKTKKKTQDPLNSNRLLDHLDNIFLYSEEFKNRIRTNARNIKHYTTSINVQKERPSLSRRRAEDYKTVWNDTLKLASQIGSNLTTDMVKRFTLNDNNYNEDDLEYIKRFIGGYRYHFYHRGLDVKGFYSFNKVFTVAFHIFHSKDQYDSSLNCKFEDYLKQLSERKEETQRQQELRYRISKNLFANLYEKKSIPHTPITDEPINTLSGNDPITTGGYIVRNRDMLIDLENAYNFDAVERDPIENSYIKIGSLARICDSTCEDLSDKFIEDIISIIISFQDPNNKVLTLFAIKKYIEDTKFIDSLEKYMICYSRLRGFHRRLNEILSQLTWIKEVNRLNNDSSLNDYSKFNILLRRKLSHTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4B2</accession>
    <name>A0A0N5B4B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4B2"/>
    <dbReference type="STRING" id="174720.A0A0N5B4B2"/>
    <dbReference type="WBParaSite" id="SPAL_0000091400.1">
        <property type="protein sequence ID" value="SPAL_0000091400.1"/>
        <property type="gene ID" value="SPAL_0000091400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000091400.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34914" checksum="8B715BBC26B1173D" modified="2015-12-09" version="1">MSFIYLQIISKTNYVSKRDIRAIILYEFKRGTNAAKTTQQINESFGEDLVSVSTAQRWFRKFKEGSEDLENEERGRPEIVIDNDELRKAVEANPRATVRSLGEDLNVSTATISRHLKEIEKTKKLDKWVPHELNDYQKMCRFEVCSSLILRNKNDPFLSRLITCDEKWILYDNRKRTGQWLDKNEAPKPKLTPMKVMVTVWWSAVGAIHYKFMKPGETINSESYCQVLEEMNQKLSQKMPALVNRKGPILLHDNAKPHVSKKTLQKLNELGYETLPNPAYSSDHASTDFHFFKHLDNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4F1</accession>
    <name>A0A0N5B4F1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4F1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4F1"/>
    <dbReference type="WBParaSite" id="SPAL_0000095300.1">
        <property type="protein sequence ID" value="SPAL_0000095300.1"/>
        <property type="gene ID" value="SPAL_0000095300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 12 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="208"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="298"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000095300.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="71432" checksum="415781976CBC36A0" modified="2015-12-09" version="1">MENIAVGLRVAILRSDGSLQDAMITDVDHETQMVKAVFDGENNMKRSKKVSFRDLLRLNEHLSEKVDKPEPLPAPPQQQQAPPRPRNTRRSVQQHQNKPSRPSSTTNNAPRMSLVNPTNLTTIDEAETTTLLRKTFTPGFGTRETTNVRKTSAHPVDDKETTSMGHVLHHKLPKSHLHYQYNTLILEEEKKLTFRNLEYNEVGQCTKKMTSYIRVRPLNATEIRGQEISSVTVPTTNSIVLFSPQAKVTTDKFITPHSFTYDGVFNENASTECIYKVACKQLIPTFLSGECATCFAYGQTGSGKTFTMHGGAGKNKSSGLYDMVSLDVFEGFKGGHLGKRGYAIKCAFFEIYMNKAYDLLDGRKELRVQADSDNRVQIPNLTNHYCRTPMEVSQVLRQGSLLRSTGKTKSNKGSSRSHAVFQFILVHNEKVVSRLSMVDLAGNERGIDAGNVDRQTRNEGNAINGSLLALKECIRHMSTGVVDRIPFRNSALTQFLKDSFIGEHSKLCMITTISPAITSFEATLNSLRYAYQVVQINSRDSLLPGQLLTEIAGVRINQPLNVINEDQEECISSPTSNDENCEGQSPTEVIEASEIETLKSMFQNAIEELDEIDSLIQVPNQKIIAVRKLKVLKDRFNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Y4</accession>
    <name>A0A0N5B4Y4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Y4"/>
    <dbReference type="WBParaSite" id="SPAL_0000113300.1">
        <property type="protein sequence ID" value="SPAL_0000113300.1"/>
        <property type="gene ID" value="SPAL_0000113300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000113300.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="78954" checksum="70B2BE2952B39C0E" modified="2015-12-09" version="1">MPSLRDEAKYYCPYCKETNYIEDEEYDAIQLKSHFEAFHGYSSKTLEKFYCQECSRRRALGDLNVKPKKVTPFWMFRHMQKKGCYRVPETEDQQENIAQEEQEEMLVTFMENSDMEAISQTIEEENKEAEDNIFDDLIDLENIHNDPHKKSLKTVLKYFSKLLNDNGTTNKNLELYLQSHQEHGLTNGNMFLTDTIESLLRIVRDDFVNEIRVISPFDPEETIFESITNVEEGNLERPIGDNKKNLGVLVSLKYIFELMCKNQKQIVETYPNKIPLQLYCDELNMNTFSNGLLQYLHVALRISGDYADISKIESVYTVAILPTYKLNTINNSEAGGRYVHFFRQFKNIFDMNCNVKFEGRNITFVLEDLLGDHCFLDHYWGINAANSDKGDNPSCRICLIPPNQYIDTVTLESLESKYPDLRRSESPQDPIFKNCKNMIYSDWFHDLNEGIISSSCYVIMQELCTNNDEFPRLQPYEISGLLLKEFKERKTSGKIFQNIGVQLEQNIISKRLSLKQETKRMSINFGSGFGNLEAMWCLHNAITELVVKYRSEKLLNFKNVLHSYGSLCNMCMKSDKLNDDDYRILRNLCNETVERTLKLTRGRYGFSKKLHYILHYPEIAKNFHDQLKNIATSRFESKHQCIKKYFTSSNNKMFPAKTIIKKSIMRTKLSSMLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5W0</accession>
    <name>A0A0N5B5W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5W0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5W0"/>
    <dbReference type="WBParaSite" id="SPAL_0000145200.1">
        <property type="protein sequence ID" value="SPAL_0000145200.1"/>
        <property type="gene ID" value="SPAL_0000145200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="212"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000145200.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34792" checksum="C088EE103277E7DA" modified="2015-12-09" version="1">MVGIHPDHPDMKSMTLIENVKSGFLTGITTRLIVQPLDVLKIRFQLQEEPTIGKERGKYRNINQAIKTIYKEEGITAFWKGHIPAQLLSQIYAVVQFTTYLQFAKCFTEVFKEYNQNKEIGDFLAGSLSGSLSITASMPFDVIRTRMVAQGKPKVYKNIFDASKKIFLKEGYRGFYKGLSASITQTAPFTGLQFLSYNCLANIWNKMISNNNSPMGSVICGGLSGCFSKFLMYPFDVVRHRMQVLASDRQGFGKATNHIGMINTFKKILYEESILGLYKGLVASILKAGVMAGLSFCSFELFAEYFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B657</accession>
    <name>A0A0N5B657_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B657"/>
    <dbReference type="WBParaSite" id="SPAL_0000154600.1">
        <property type="protein sequence ID" value="SPAL_0000154600.1"/>
        <property type="gene ID" value="SPAL_0000154600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000154600.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56716" checksum="4718508688912B3C" modified="2015-12-09" version="1">MTSEKNSTSYYNETKDNFSYDEDLESKLRELNEEETSWSSIYLVYVMLFFGGIQITVYFTSMWPYLLSVNPKANVNTLGWIVASFSIGQAIGCPLFGWWSEKIKSTRIPVCFGLIFVMTGNFIYSILANFSSEKVSYIMILSRFLVGIGSGTNGVLRAYNSTACTQSERRKVVALGVGSMTLGATLGPVIQTIFNPVGVNGYLLFNIFKLNMFTFPPLVMIVICTISIIFFFTSFKETFIGIDEDNENNKNHNDKMLKDKKILPPFDKIAVTVCIYNWFVIQTMATNVEVLASPLTIVMYNWTDKEAIFYNGIMLGCSAITNFINFLLQAFTRLRYVDARKMIITGIGMFFIFNIINYPLPFYTEKLDYIEYLPNTTIESTYYSGGCSRKFDWCEDTPRTPFILYTISFVFCLGIGFPSISGPNGALFADILGPRRQGFMQGIMELFGSIARAIGPVSATWLFYHSGTKYCMLMQGTLVFIAISLNIIFRKRLIPLQIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6X1</accession>
    <name>A0A0N5B6X1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Charged multivesicular body protein 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6X1"/>
    <dbReference type="STRING" id="174720.A0A0N5B6X1"/>
    <dbReference type="WBParaSite" id="SPAL_0000180800.1">
        <property type="protein sequence ID" value="SPAL_0000180800.1"/>
        <property type="gene ID" value="SPAL_0000180800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000939100.1">
        <property type="protein sequence ID" value="SPAL_0000939100.1"/>
        <property type="gene ID" value="SPAL_0000939100"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001089100.1">
        <property type="protein sequence ID" value="SPAL_0001089100.1"/>
        <property type="gene ID" value="SPAL_0001089100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000180800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000939100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001089100.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22765" checksum="A4B72CD73E1A175D" modified="2015-12-09" version="1">MGNEHSGASALDNHLFNLRFAAKELVRNSKKCEKEEKDEKNKLVNALKKGQREVAQVHAENAIRKKNESLNYLRMSARIDAVAARVQTAATQKRVTQSMSGVVKAMESAMKSMDLEKVQNLMDRFERDFENMDVTTATMDNAMSATSTLNVPQGDVDMLMKEASDQAGIELNMELPTGETGTIGTKAPTQAENDDLSQRLAALRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B724</accession>
    <name>A0A0N5B724_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B724"/>
    <dbReference type="WBParaSite" id="SPAL_0000185350.1">
        <property type="protein sequence ID" value="SPAL_0000185350.1"/>
        <property type="gene ID" value="SPAL_0000185350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185350.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16760" checksum="86F46022524E93EC" modified="2015-12-09" version="1">MYSIFIRTKMNYLKLVIFVAVTILLDIEAYYIEDPSFIHERWKNKNTHSPTMIKLARESVYAFNEAQNTNYFFESLDSAQKRKEKEPHYKLSISVAAECGPFNLPCTKHLLSDVFGHPKSNKELKIDVEEDENYYPHSWNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7W9</accession>
    <name>A0A0N5B7W9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7W9"/>
    <dbReference type="WBParaSite" id="SPAL_0000214300.1">
        <property type="protein sequence ID" value="SPAL_0000214300.1"/>
        <property type="gene ID" value="SPAL_0000214300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000214300.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22997" checksum="3C8A06EAA10380CB" modified="2015-12-09" version="1">MSPNVSLTNSMSKRRKVLGESNIKNFNKHKVEREILDKDVGNVNCHVTKNTVEGEYDEEMSSFGTINQKPSNMVVVVPGESNRKVPLSSIKTQVLEPIFVSCNIDELKLRRNIHTQIHLSYLKSLYKKDKQKTISKWIVGSKERIEYDCKVNSGRFMLEPSRNICQNNSMIVDAMYNLYNNVTQEIFDTVSGGRDFSSDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8B5</accession>
    <name>A0A0N5B8B5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8B5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8B5"/>
    <dbReference type="WBParaSite" id="SPAL_0000228800.1">
        <property type="protein sequence ID" value="SPAL_0000228800.1"/>
        <property type="gene ID" value="SPAL_0000228800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="49"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000228800.1"/>
        </source>
    </evidence>
    <sequence length="1021" mass="117309" checksum="7365C0F5987AD65F" modified="2015-12-09" version="1">MRIDKTGREANQKAITLFAESKKKKGKKRHRVSIRVEAEECQNLLMHGRVVKFPGRFTPYGSQKMIIHKNIYSFDRGLNVLVESPTGSGKTMALLSSSLAWLHDYNNRRELSQKNCLQHGRRKIEDLKEEVNKIEELLNNIKDGSEIKSKRKKSLDSSENIDFDDIFGFKKEGSATNKVPELFKKTSLDTIPYANTLKKKAKSEIVALRPETKCLKENISAKLLKSNSFLSNNGKMHGNKSIKSEVIRQEGNSSDEVTDCSENKFDCTCLPKVRIYFATRTHKQIAQVVKEFKRLPYGHDRNVRHTILSSRENCCVNNAIKHSNTGDITSNCIDINSTTGKKSPDKKGCTFKNNVMKSYIGKYKELRNELIENDTPVWDLEEIVEYGEARGLCPYYVTSTILRSDADLVFCPFNYLIDPVIRRNTKTTLKNDIVILDEAHNVEDVCRSSSSFEFSEKEVIHSLNDIYNKHQKILAPDMHFGKIDDIPDASFRFKEYETKLNTMLGFFKNFLKWFRSFADEVLKISNNSSYSTTNGKVYTTQFIYQSLGLFDLDCYIKNPKCLEELQKVWKDLSHDNGESIENPNEKETKQELKLLTEALDFFRPCMLTMSCIEKFVYFCYFIKRNPSAYRLYYSITESTKDLNMFSFNYQKSSRMNDSNALYLSENQYYNGDSSDQQNEAEHLIAGEQYNVIKERCVVKLNLWCMDPSICFIDAFNDTLSVVLASGTLSPIGTFTSELGMEFTQIGQGRQVIPKEQIFTCIVPKGPNGIDLICSKDHLDKQNKGQKITTIEELAYLIFDVCKVVDKGILIFLPNYNFIDLIFDAMIKLRLMNKLKEIKKVLKEPKKGGELESVINQYKRSIESPSQISSTCTGAVMFAVFRGKISEGIDFPDDMARCVMSIGIPYPNFGDPQIREKKSYNNMFYKQKKLLNGSEWYKTQAFRALNQALGRCLRHRGDWGAILLVDYRFSDKAHNNDLNMISKWVIENLRPINDYGSLIENLKTFIKERNLGDSNSTNETTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9P4</accession>
    <name>A0A0N5B9P4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9P4"/>
    <dbReference type="STRING" id="174720.A0A0N5B9P4"/>
    <dbReference type="WBParaSite" id="SPAL_0000276000.1">
        <property type="protein sequence ID" value="SPAL_0000276000.1"/>
        <property type="gene ID" value="SPAL_0000276000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000276000.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46237" checksum="3B365C487C369285" modified="2015-12-09" version="1">MSSESSSSEESDQLKNGNHKSNGKDSRYNINKRLNTVIDLYIPITICAVIGLLIEKYISPFSEIFSLAMSLIYNDKQSMIKAKSTQYTGLLDSIPSLSMLLIITLCFLGVIIVMTSLLVFLYVKGFKRWLEYFFYIQIFFSLMVTETKILGKTFVYFEILVSDWTLTIICVIFSLIGVFSINGFGPLKLRQFFHIILGVNIALLFVSLFPEWIIWSILITISSWDLVAVLWSKGPLNILVNTAQKRNEELFSALVYSCMAHTEIVKSDDNKKKLDDNKKDEDKKKVDNSKKDEEKNETNNKKKIIEDNSEEEENENAKLGMGDFVFYTLLILHVYRYKDPISLVNCFTSILTGLTMTIFILVYFKRALPALPISIFSSIIFFFGTYYLGSPFYQEMANNNIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA56</accession>
    <name>A0A0N5BA56_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA56"/>
    <dbReference type="STRING" id="174720.A0A0N5BA56"/>
    <dbReference type="WBParaSite" id="SPAL_0000292500.1">
        <property type="protein sequence ID" value="SPAL_0000292500.1"/>
        <property type="gene ID" value="SPAL_0000292500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101283">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="921"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000292500.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="133474" checksum="90EB5B1CE8DD7F0E" modified="2015-12-09" version="1">MANQSVIKEHTEAIRKLEEDNAITLATVKAQFHSQLEEKDNEINNWRNKYSQQVIDIENVKKEKENLMVLAETLEQEKKEMLEKIVETKKQVLESVENDEKNKRLQCEAEFNEKLTSSLKENDSKWEKKLISLKEEYDKKINELQESTNVDLINLTDKNYLDENNQRILEELKAENNCLKNEITTLKSSSEKEISDLKKSIEFTSERHNSEIDGIIKEAEEGNKDLKKEIESVTCKYNELLKSVEEERNNLCEKIKSLEVELDNNNSTIAELRKMCDTQKSDLLTELNKLKVQFESTSTERNNLSLKIKEYEVKLKDLEEKYQIEFNENNSLNGKLEEIIIEQNILKETTKNEIGELNMLIESKKQEIINLLNEKEAIEAELTDARLIKKLKCQLEADLENMRNELKETTENLTSSELRYNEMVNKLKEENEKLKEEKDLYRKDEINNADYENSEEILNKKLVYTDEGINSLENDYEKEQLKQELIEVKKSLQDSVDEKNNFINQLDALQNEFNEITSKIKLLENDKLDLLNELQNSNNQVDELKNKNENLHDLEASLNNIKQENSDLKLQLNDLQDKLDLNSSEKNDISEKFNAKLEEKENEIKKLSDEIKSYESSKNSSDILSKEMEELKVSNENLRIEYMQKENLISELREELDVVKSDKDVLNKEIQGLLQSKQKYLDDIESSKTRVVKLAEEVDKLKDMEIGHKEHINILQEEIARKNEEYEKAVSEKDSLISEVECLKRQVKENEIALSVTEKYKLEMDKFKRDAEMKVEEMKQKVSQVESDRNSKYQTEMEKMKITLENKTDELANMKAAKMQVEDLLKEAQEKVDDYTTKLTDLEEKLQETNSLTLKLLEKEDIIHELQNQCSKLEEDYVEYKEKSAITIASLETKITEIEQSKATDVKKAMAKVDGDQKRMIKELQKEVKQLYQELNKTSNANDALNEEIKKLKQNGSSGENSITKLTASNLNNEIEGEENDNVTKKTFDIIDYEELNVLREKVLNYQSKLFDLEEKYAKETSALKEEIKRNNLTKSFENNTLANALEIKSINHSTTNKLHNQLTTAENYTFAEPTEAEYLRNILYRYMHERETLGRGIVTLAKVIGTVAKFTPEQMEAVLNKEEQRHLSWIQGTLLSGSSLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAA5</accession>
    <name>A0A0N5BAA5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAA5"/>
    <dbReference type="WBParaSite" id="SPAL_0000297500.1">
        <property type="protein sequence ID" value="SPAL_0000297500.1"/>
        <property type="gene ID" value="SPAL_0000297500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000297500.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31371" checksum="3283264CA402BECE" modified="2015-12-09" version="1">MDDREEKIKRLKEARSKYSDLTRLKLNKTTSSREFSLGQVRKVENNFKPLQENYKKILENKPECTTPVSQRFSLRPKQSIIAMKVTSTVPSKGKIENIENVTVTDAGKKRAMELLETVARRNNLSSDVKSSPTKCLNSNCKEQLLLNNVEKETKENVRNFSVIEEKVVADEVTDTIKKAKSSRRVCFADDSTTLTYNYNETLTEDFVCETPISSKFSRQPRQSIFGVKQQKSTNLPSTTRSIDSIPVTEEGRKKAMEHLYRLIETSCSRNRTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBK9</accession>
    <name>A0A0N5BBK9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBK9"/>
    <dbReference type="STRING" id="174720.A0A0N5BBK9"/>
    <dbReference type="WBParaSite" id="SPAL_0000341600.1">
        <property type="protein sequence ID" value="SPAL_0000341600.1"/>
        <property type="gene ID" value="SPAL_0000341600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000341600.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49867" checksum="91D4FE9E20A0E439" modified="2015-12-09" version="1">MEDLSVQTSILKVIEKKDSSLMSPAVSNSYRQLSSDDDLKFRNSNNKLFYNSPQTLVRMRPENAKSRNSPEEADHYLETYDIIKFRLYIYFNTVVIFLIIGAAIFYSLEGNVSVEREQEYNNRCKEERKQIQAKVRQEIEQLAYSQKEKTMYHVFLEEKLYKKMEKLINEMDNCHRNINITKAQELSFVKSFSFVYSIMSTVGYGDVVPLTVSGKIFLVIFSIITIPCFITFYIEFSEIITIKLIKLYINLYDKLNTKIGIICKETSSTTILKDQETYQTSKAIISLASFLIIILVTCVLHYEIVRETPIKEDFTSSFLFVFESIALIGLGYNVPEDTIKYIFLELPFIVIGVSFFGLYINIIVNCLRHTLPTFISKKYPIKGMGVNSETHFIDYILKRRKVKFTDITSDYRSDVYLKSSLESCMEHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBL7</accession>
    <name>A0A0N5BBL7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBL7"/>
    <dbReference type="WBParaSite" id="SPAL_0000342300.1">
        <property type="protein sequence ID" value="SPAL_0000342300.1"/>
        <property type="gene ID" value="SPAL_0000342300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000342300.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="53596" checksum="E2E563C11AE8DD25" modified="2015-12-09" version="1">MKTQRTISFVTLMGISLLRKKILQYIGSFDDLENLSKICRWMNYYVQIESIKRGIYFYDDRNRIDISVKEGISKDLDSYKLEELEIKNSSNFLKKWDFSEKSTNEFISYDNLTTFDYKKDVFEIDENDIINTKKKISEEINLVLNCLMRKNAEILEFTDDLRKNPFLMLYLMKHMNHGNIKFFKIPDTFVTYYMDEYNKKFYYGIFNGLPKLKELVINIDYIYNEEPNYDEVYNKFMNSMSFLENILNELSKKRNGTLVLEHLNGDHNKIVKFIKMIYELKDVEIYFEPIRKTNNEKNLEILYNNMKIIVSMMPKTVEMLKLTRMDYLTKEVTEVINQFMPNIKLFVTQNVSFKDLDCLSSFKHLQAFIYNQNYPIHIPGTVKLVGICNHYIHNDGNLEIITFNQELINTYSKRFSKRLSSEFRGCIFFNDIRQWCMYKKIISNQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBR4</accession>
    <name>A0A0N5BBR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBR4"/>
    <dbReference type="WBParaSite" id="SPAL_0000347000.1">
        <property type="protein sequence ID" value="SPAL_0000347000.1"/>
        <property type="gene ID" value="SPAL_0000347000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000347000.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="79058" checksum="48C246965E315F74" modified="2015-12-09" version="1">MATEIFSDKDKEKYIKELEAVKKIIPDSPTIQAIQDSIKKGTPLPFAEIPKLHTDKEAILYANLVQPNCPDASTSFKLKNYLELFIETSGIQAQNAMRRENVEFKGFWSSVICFIITLINHQTTMIIPLLIYEYGYGFVKWLLVSYIFVCYPALVFVITLSQYSGLDSSRVYSRIKKVWCGMEYVVLLRTSYSILLVLQELQYTSGPLSMLEEVRETDRNYLDSCLTSEDGCINLGFIHPCSTGYGEDVEDNEQCRRLNQVNFEKFIDPDDVIKTISTSQYMFKMLNTPIHEKTYLFSLIIPGLIVCLTTFFLYFGKAKCVVIVALLSLPILFGQVYGLVLLSGNNWSTEFQQFFNMEFVPSFNMAILVLNLTIRSLNMIDLVPKISTSISSQMKAIHISFFVILSVIIVISISTTLYITSTIFYKQLLMKNITGYGRIQRYALSNLLQYIALPELFIINNNQYVNKAYIICTIIQRCFILSMLIEIFYDYIRTTSMRFYNFFYNYNFPTKLVVVLFCYSSATFVLESTYNSLMSAQFMHQFLKIDGGILFIQFFIIGFVYGIDRYLGHLREMNGKVQMRDKVLKAFKYISPMLFGISMMATSDPDKREYYSDRMYHRDYVIASLETSSVHILAIVTCPVLIFLVVEVVKTCISGYYWKTAFRSMDVWSKRENKFIKTSSLHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCJ3</accession>
    <name>A0A0N5BCJ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BCJ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000374000.1">
        <property type="protein sequence ID" value="SPAL_0000374000.1"/>
        <property type="gene ID" value="SPAL_0000374000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000374000.1"/>
        </source>
    </evidence>
    <sequence length="3140" mass="355326" checksum="2FD0983878779617" modified="2015-12-09" version="1">MVPHQVITGAINIKHSPYSVGYKNGLPFIASCVGRDLVILDKDLNRIQLISNTFLDEDKRSSRISAINCCQESGKIVSIYGTTIALFEPKTNDCKDDEVGVKDEWRLVRKFESKDNVKAISWALDGNRIILATDRELKVLQARPVKQNQNINFSIDYDHDNSTKYDLMWKQAISSPIRSISVSSDSMFFATCGKNDTIVKIWYQVPSDTNVNSLYTGNFSFTQLPHPDVVTGFEWRAVSKDVPRKGIQNAIITYCKDNVSRIWKENVINDLFYLDISGESGEFCTTDKIIKKRSVFKNFGIKGLKMKMLNKIGKIVSDKKKLNGKNFYFNICPNSGSTQDLMSNTIQSSNVTFYLSTSVDVENDSTICRSLSNEKLKLSKPLTIHWLNNKEIMFNIGFEKILMDSLKDINESILNEENKLKNKDNLNAEDSAVEGGKKSSSGLGPFQADMYSPSMSSESFICKDSLDLKLDKLLSEWKNENDVLYAIHPVDGSLITWNLFHLDSAENKVENKLISRTPNVFPVTDASSLKAEIHTFRHHNNTLLMEILQKSLTQIDKVPTSDDGSEALSDRSTTPPTTDKLLEAANRKISDSKEITLKKVLGLNSLSVLTSHDNGTLNLWKMSLEENSNFKTISHVRHIVRMCGHRYDVSEIVPHPILPLAITTSKNTNDGWKNMEENGESELILWKISPVGQLAVNGGISELARINSRSAECFEKTAWIPHVITSSNMGILSPSSCFISSVDGKLEIFQCIIDARKILSKMQQPLDDVHPSRKRYSLNYISENEMDNDEVKYEDEIDKKCYTSDEEEEEKINYRNMERCQINENADSNENNLERSLVSTQSASKPGCIGLIETLENSEHDSKDILLLHVFTSNSLTYKNNEKNRHTEKDSNKFFVLMVSKNHTDPVQQLWKIWSVIIKPDERISVSKECYSYSSAFSINVTSELLYQKHFNINNDDTLELLSLQPMTDHLPSSNIYPACQPPFHLIGHCDDNSLHFYKIFVDEKSNSYEFECIEESMVGGEDSSILVGGKIASSKAANGERFAIAFSSYGKMYVSVYECESTGGVNWRLEDSFPIRTYDKECKFQTSGSAVILKHDEENVKLDWVSMEDGGYILTTAFRNEILFYTYMSYDLAQKNIITMQDPTESGKAPLVRQPSINPKQFKMSFQKTHWICIKHLELHSVNCLKPQPTAVSWVRDGFLVVGMPSELLVYHQWNFSNVEKPEIKNNINKLLDKEKQGMTLSRSSAMFDQLHKATFTDKSGQSSMKKIVSKIFTETDFENEKINGGKNKSIIDELKDDNIFKLINDVGIFEAARLANPMLPQYHPKQLIDMLNAGQIGCVEAILINVLQEIRRNKNPPLKKLKRKTSVRIRGKDNRKLSLSDEEDMFNVDATAKESMALKDETLDYEEIEGFAPIPLHELLKIQNVQCSTIDNLQQSDNVSKPVLENQLSFNDPPLSAVNNETKYDDLFGGPSNDYQESTASDDFNILDSDEDDVKDEEDEEEEKKVDEEKNDTAEAETNIIKNLYNIDDSRPKFTKSDNEELTTFLMHSHLPGLSSSDQIQLLAIADTICHINKGASLKQHCFMLNGQSKLNKEFLKKKGLSTAIMAWAFHSESESELLTEVLSHQGPQYTWNDLKSFGVGWWAKNPANLKICFEKLAQQAYQKNNNPMDASLYYLVLRKKNVIAGLFRNKNEHSKAVFFSSECTTDKERAFAQRNAFSCISKGQFENAAAIFLLTNDVRNAIKVIVERLNDIQLALVVARIYILQKEEQDQITKELILKHVLGITEEELNNWHSKGKLRDAGEFSDPIAYSKAAVKDPFVRSMGFFLIKEYFLSAHTLLMEAKVNINFEAAIGGIEEIEKSLPDIYNLFVYLRNHSLVSLQRINISGLRTKADTWEMSEWYKRVITVSERRLYFRTVDIHLTSGCPFLALNILITLPKNIESVVADASCLSDTFSMKYLNQNNSSYKGSLWNGNDQFIQKMTFISCLKMFIDEISNVRCNISNDGANMRYEILKLIENDINVLRKLCQYNITSTNINNFSNYINNLQTPDTLTKERTQFLISHQNLIRSFASYCALYSSHKQSLTSVQIELLLLLLEVQQGNYFLKLTKDDDEYKFPLLSASCSPAKMAAQTPISFIEEQNNDIMATLLGLANPPIIGEGISDAINMLSIAQGLSTCLFQVLSDLDVEKIVKDNDYLNYTLIKSLSEIKFPSVDKDVNTIPSKWPGVSNLTNIINIEKDDDSPALNLLISEVYIAINMTVFCYSLAVCDAKLLLKVIGRKLTIDDFGRVFGGGGSQIFKSISESVLRNENEGDVNEINGEENSNCNSSSPKVNQHLPTVMENKVTTNDIRVFSTYSDIIGFRSDGDNKQLNRLSIFPKNFNDNSSPMVQKISSPARLVNLQHQYSSTTSKRNNSVSFDSQKSFTEEPKYGWVPPKKHVLQYLLDRIIVKNGELLTGDVTLDKDKIEEAKYDEFGEEITDFPHLTPYGYAWTLLRLAAIKLQKKRIEEFVNLCGIDMDQISCHSSNIDNILKLLDVWYYNVELKIQSFTDGPPSNLLPNMSMDDYDKSKIVPFNEKYRSLLDEKNTPFEVVDNLSFSTNNLWRFLVSTSDCTDLFVRYIYGSKIQSSIEMTQNKETVGSMSSSNGNISHWGNSKIFRIIHKEQEPIVTFTVNKCNTNQIVVSNGREIQELDIHSIFEEDEKENLGKANILFNQPEIDIVLNSIHSDPMKNNDNYQIFVENTKINQPFTSATTIQRVQINGVRRIESHPNRDIYVTGASDGSIFLRKWNISSPISKVREPGCYAKVTNIAFALNGEKFAAVDGDGLLCMWQLTNEGPSMIRTFFNTRAYSKSAADVCYMGHSSSTLVTAGHGGENESVILWDTLQKRGKMSKFLKGHPDGAVCVKYCSQNSIISAGKYGEVNIYDIRGSENPRTTVKLFDNATVKYMTFDKSEDLLIVGSSEGDIKVFNYATNFDLRDPPLFSFTGEHHNKSGFSLRQVGSSGAVCVKYCSQNSIISAGKYGEVNIYDIRGSENPRTTVKLFDNATVKYMTFDKSEDLLIVGSSEGDIKVFNYATNFDLRDPPLFSFTGEHHNKSGFSLRQVGSSTVQGIQKVYIDESRRVYSCGGDFSMKIRSLPRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCR8</accession>
    <name>A0A0N5BCR8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCR8"/>
    <dbReference type="STRING" id="174720.A0A0N5BCR8"/>
    <dbReference type="WBParaSite" id="SPAL_0000381300.1">
        <property type="protein sequence ID" value="SPAL_0000381300.1"/>
        <property type="gene ID" value="SPAL_0000381300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000381300.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39891" checksum="3EB3F5C03D6E05C8" modified="2015-12-09" version="1">MNDSIVIDTSLPYCNICLPSTDPKYQAYNIAVSGVLLAFVGVIGFFGNILVIRVYTTPSMRKYSSNIYLAALGTSDLLMICTAMFLFVLESWRHHSHPFVAYIYGFGAPYIFPLGAIFQTTSVYFCVAAAVDCFIHVVLPKKIGDKCCTTLIAERVVIVITILCILYNLPHFFELQSVLCIDTRYETNNLQICPTDFRTNEIYYTIYYTFLYTSFMAVGPLVVLVILNICVVVSVCSKSNTIEEGEVEEEDGTISLILVVFFFIFCNFIALVVNFLELIFQQQLEATMAYLIDMSNLLVVINCTANFFVYLIFSPAFKRTLKELIFPNKGSKDEEEIWKESCENGSSLQNILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDD0</accession>
    <name>A0A0N5BDD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDD0"/>
    <dbReference type="WBParaSite" id="SPAL_0000401600.1">
        <property type="protein sequence ID" value="SPAL_0000401600.1"/>
        <property type="gene ID" value="SPAL_0000401600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000401600.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="77809" checksum="ADE4EAE786E257AD" modified="2015-12-09" version="1">MRILIFFLISQALTEKSIWDGNEKGKNFMRGVAYIRNISDYIWQGNVNKSSKSLPKDITFLKHVTLRNIKILEADITKYEPGRVGVRFQEIKGETQYNLIFGGAYLNDTYFHKMDHTTCQMSYCENGLYFDSDIVEYKNMLDVYESKLKNVFYAKFVTSDMNFRLDRFTITGSNFPLILCPYKGWVAKYSGTEFIHYTTTGITFSNLYERQILLPGYPRSDDVDIFVCGYIKYEDGSQLTISHEIEIKDYYNTDSIKPINDFRHIWKCSGGDTTDYHYFIYSYNAKGNHNMRHIKKDSLNGDQFYYNDTIYLYSEADTKKISQLKEGIKDDYTMEQIEPLCGWKLPQLKFKLRLESSDGSKVLDGKNGIQTLDVREDMLNKDIYYKCKIVIEEATQHPFLSNYYDQVMETLLVSEDDDGNQIFHNKINFDKSFDGFKKYECAIIYKNKDFEYGHSVEKLSFLTIPLNISITNQDETWRVRDDIVIQCQKRISNMGEIDSIKVEISENFFIEYSNVTSDGIFEVEGDFVRSNFGNLIKSKNKKDSDVKHLKTICNYKLAGGKMFSIVKSGTVLQKTVVTKQKGNRSKKGNKHQKIIIIGLIVGISILVFAIILAITTLFVVKYINKKRRRGKDSSLSSSSSFSSLSKSSMSGSLLSASALSSVSHQNSKSKISKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDQ1</accession>
    <name>A0A0N5BDQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF362 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000413400.1">
        <property type="protein sequence ID" value="SPAL_0000413400.1"/>
        <property type="gene ID" value="SPAL_0000413400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000413400.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32865" checksum="7800099100611401" modified="2015-12-09" version="1">MVYIDLASSRKRPAQDYTEAALSIDDLVFKFLLKHPHSEEFVSDLYDLLRNISVLCCESSLSASLSISKFHKQFLVAEKEIIKLSKDVYSIDLNRDFNRYVEEYKIPKNNLISHSSLNFILYFDDIAVNSPLGAFAKTGLQTHCAYKLILDPFNASSGALSNYRTYAFVKASIAKGTDKYKQFFLDCINSFLNSRIIIDNVEIGVKIHCVTGDHPVLQNLFGFKLNFRSIGKVGSCRACTIPNEKFSEFRTIESTEKYLRTNHDLEHLLPKYCNYVTDPHHDWSQGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF65</accession>
    <name>A0A0N5BF65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF65"/>
    <dbReference type="WBParaSite" id="SPAL_0000463300.1">
        <property type="protein sequence ID" value="SPAL_0000463300.1"/>
        <property type="gene ID" value="SPAL_0000463300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000463300.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42656" checksum="D1F2DB94DEC694E3" modified="2015-12-09" version="1">MLKLFRTESLWRRSSNKKKDLIREVGVNSNTKNDYSQFIPSPFLRINTIEDISDKCIIEILKRVDCKDILNMRLVNKRINKIIRRHFTEFNIKKIEEIVLVGCGEDKCYRLNESMFLLSPEERRQFSVSIKDISKWVRYLMITQTVSMESLNFSQSCYKTLRRMCENSVYELLLTECVISINYEIFSSLIRTLYLSKVVIKRCVLEDCQLLSDHLFTSNLQLKVFKFFGINKKVDCIYAPLLSNKTLATWADSASWPEIILLQGVKSNITHNGIKYLLEAFHEYSCMIEKNNMKNEMLKSTRSVYWDLGFIRCQLSQLVAVIRNYNRWIRYIKRNSEQISFVYRYSNTTHPLVLNIYIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFX1</accession>
    <name>A0A0N5BFX1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BFX1"/>
    <dbReference type="WBParaSite" id="SPAL_0000488100.1">
        <property type="protein sequence ID" value="SPAL_0000488100.1"/>
        <property type="gene ID" value="SPAL_0000488100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF175">
        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894303" description="TEP1-F" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="12">
        <location>
            <begin position="562"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="13">
        <location>
            <begin position="825"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="14">
        <location>
            <begin position="1483"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1595"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1597"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000488100.1"/>
        </source>
    </evidence>
    <sequence length="1637" mass="182648" checksum="5CD8F395D2C85F34" modified="2015-12-09" version="1">MWRGYSPHIILISLLLINAIASQLNNETSNDSTNGFIPTVQWEEVRTTIMMNTIESNTITPKHEDPTDLSTTTIIPILDISNPFTNKNPKKEEETKNYKGSYLIIAPRVVRPSLPYAASVNILKSDFTDYIVRLEIRTRENNETIAAKVVTNITPGKALTVTIDEVPGDVLVPGQLYKVYIRGETLNGLLMFEDEKDINYNSKSLSIFVQTDKAIYKPESTVSFRVVVVNPELKPVKETETVSVKIVDPNKNIIQQWNEQTLKKGVFSSTFTLSKQPPLGDWNIEVQTKSGVKFEKSFTVDKYVLPKFDVSVKTPSFITVNEDLSVLIDAKYTYGKGVGGKAKVVLELPWHRWHLAPRPVIVNEDGSHALNTFESRIERIVTLNSLGEATVKFTNEELKKHKLITIYGGSTVRILATVTEDLTDVQRNGSAQIIAYRHDVKLEVEKQGDTFKPGLNYNVIVTLKNMDNTPVKSTVPKRVKVTTFYNFPYEEGSNEVKQVNESKIVELDGHGTSVLTLKPPINCTSARVEAHYDRDGKDNFTNALIYTSLYVEAGKSPSGNFLQLTADNEGTVDVGKPLSFSVKSTESLKSLTYQVISRGYVVLSNEIPVSGQHAAITFTATNQMAPKSRLLIYSVRDGNKEIMVDALDFKVDGLFQNEVSLSIDKTSVEPGEDLKFTIKAAPESYIGLLAVDQSVLLLKSGNDITKDIIEQDVEQYDTMDQPGDYRPFDMFKRKKRSIWYPFWGIGGKDAGSIFENAGLVVMTDALLFKDEPENYMVAESVMRKGIDGPPMPVMMMMNTASVDGASSESSPEPLVIKVRSEFPETWVWQDFDSDNGTVTFETKVPDTITSWVSSAFAINENLGLGISPSNPKLKVFRPFFVRLNLPYSIKRGEQFALQVLVFNYMENEQDVEVTLKQRENSGFEFVSEDLTSIDKNESPYINKRIISVPGGGISKAVYFPIVFNEVGDIMLNVLAQSQNAGDAVEMPIKVEPEGYRVDRNIPLVMELNNDTNEEEVNHEDSDNNTEDEEKPKNESTTKIYKYTKTVNMIFPSDSVQGSKFAKIDVIGDIMGPILSKLDSLVRMPSGCGEQNMLNFVPNIVVMKYLSATHKNIPSLTKKAISFMEAGYQGELTYMRPDHSFSAFGKSDSHGSTWLTAFVLKSFKQAQEYIYVDTTILTHAVNFLNSQQQPDTGAFMERGEIHHKDMQGGAQHGGVALTAYVTIALLENGIKNEKAIQYLEKNLLNIISNNSSDENDSTYTLAVTTYALHLAGSEKANSGMKELEKRKITSSDGTVYWSTTPKKGGIDRSQDKDTSLYFYQAKPADVEMTAYVLLSYNKIGDTHTASSIVRWLTSQRNSLGGFSSTQDTVIALQALGEYAEHVYANEINAEVKIEIGNNEEHTFTVNNDNSLVLQSYIINNFDGPITIKGSGNGVVFLQIEYSYHKTATRDESVFNCSKDIKEVRSGNRIQMDLCCNYNKVGSKSNMAVAEINTLSGFKYDIDETNKLTEVDDLQRVDLDNDDTKINIYFNPLGGNPVCLSLYSDKAYQVVDQKPAQMVLFDYYNPEEQLKSTYSIKQSRTLRDICNECWSNMPQDKVNNSSSTTYNSNDSSTSGVSKGVTLSLITDKGGEKASKIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGA2</accession>
    <name>A0A0N5BGA2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000501100.1">
        <property type="protein sequence ID" value="SPAL_0000501100.1"/>
        <property type="gene ID" value="SPAL_0000501100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000501100.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14255" checksum="8A9391F43FCC6B61" modified="2015-12-09" version="1">XFKNVLHSYGSLCNMCMKSDKLNDDDYRILRNLCNETVERTLKLTRGRYGFSKKLHYILHYPEIAKNFHDQLKNIATSRFESKHQCIKKYFTSSNNKMFPAKTIIKKSIMRTKLSSMLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHL1</accession>
    <name>A0A0N5BHL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000544900.1">
        <property type="protein sequence ID" value="SPAL_0000544900.1"/>
        <property type="gene ID" value="SPAL_0000544900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000544900.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11967" checksum="982F3AF968C27B88" modified="2015-12-09" version="1">MNNCALEFNYEDILFDPLLGKAVSNLKNTFGVIMLNKHAVDITLNWMCNVNDFINFEDEILFFTLDKESKHELESKYKNLNIYTWDRIKFKKHIWCNNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHZ3</accession>
    <name>A0A0N5BHZ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000557800.1">
        <property type="protein sequence ID" value="SPAL_0000557800.1"/>
        <property type="gene ID" value="SPAL_0000557800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009924">
        <property type="entry name" value="DUF1459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07312">
        <property type="entry name" value="DUF1459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894405" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000557800.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9856" checksum="7BCFA20587026014" modified="2015-12-09" version="1">MNSKIIIAFIAIIIASVSGQYYYPSAYSGYYPGYAGYYGYAAGYPTYSGYGYAGYYPSAFSSLYYGYGSNKGNTNGDAKATNPQVKLTNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKB8</accession>
    <name>A0A0N5BKB8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase I subunit RPA1</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">DNA-directed RNA polymerase I largest subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">DNA-directed RNA polymerase I subunit rpa1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 23">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BKB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000637700.1">
        <property type="protein sequence ID" value="SPAL_0000637700.1"/>
        <property type="gene ID" value="SPAL_0000637700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000012">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="800"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000637700.1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131343" checksum="6EDC6368A52EDF97" modified="2015-12-09" version="1">MNRQPSLHKPSIMGHRARILTSQKALRMNYTPCKAYNADFDGDEMNGHFIQNRVGQTEARELANVGSNFLVPKDGTPLLGLIQDHVVSGVYMTLRGRFFNKEDFMHLVLSAFGHVSKRLVMPPPAMIKPEVLWSGKQLISAVIMNNIPKDSPKINLTGKAKTAINCWTVKGYKAPPFNMSESEVIFRNGELLVGVLDKAHFGATQYGLIHACYDLYGNRVATAILSCFSRLFTTYLQFHGFSLGVADILVDDEANKIRTKLIKKIRAVGEECVRKTFMLNANATELEVKHVLASAYNNPQGDISNVKKWDYSIKQELNKLNDKICQACVPNGLIKSFPMNSLQMMIQSGAKGSMVNAVQISSGLGQIELEGQRPPLTASGRTLPSFKEFDPSPRAGGYVDQRFLTGINPQELFFHTMAGREGLIDTAVKTSRSGYLQRCIIKHLEGLKICYDLTVRDSDNSIVQFRYGEDGMDIGKVCFMNEKQYPFIKDNLESVRKACVPKNVRDKDFHVSKLQKQWKKYKQWKEENYAKKDYRSGFVEFSKEHRGVNKGELVKMWYKMSEDEREEYNNRVPRRLDTLDVVYNPTHNLGALPEKMLESIDKFSKKIENPSEADYFKRSVFWKGMQSFADPGENVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMTASKNISTPMCEIKILPHATKEQLENIRRELDRIYMKEVLSEMSVDETITINQSKAIRTYNIRISILPKKKRDKLINHISCKKILNAIEKKFVKELAQTIHKRYKDITMDQSIRSQKLRGGNIAAGVVDDEDVPVSKKETRQDDDTDDEEAVDADATLAKLKKRRAEGDQDYEGEEEEIKEVKMEKEVNALDVDEEENESDDNNQSEMESSRNEDSEMGEGCRNRIDAVINSHMIISNYTYDSVNSRWCQISIELPFNSKSKFDVHALVEQCVEKFIIHQTPGIEKCVFAEQTRGGVTYNVLQTQGINFQALYKHLDVLDVNSLYSNDINVMLENYGCEAAGQVIAREMTNVFSVYGIEVNPRHLSLTADYMTYTGVISPFNRIAMSYTPSVLQRITYETSLGFLSSALISGGKDTLQSPSAKLVVGQLMKSGTGSFDLVSSLQPRSSTKSSLPQVKEELETNVTFKEELLNGTANEHIRSIFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKT6</accession>
    <name>A0A0N5BKT6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKT6"/>
    <dbReference type="STRING" id="174720.A0A0N5BKT6"/>
    <dbReference type="WBParaSite" id="SPAL_0000654100.1">
        <property type="protein sequence ID" value="SPAL_0000654100.1"/>
        <property type="gene ID" value="SPAL_0000654100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894741" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="595"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="907"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000654100.1"/>
        </source>
    </evidence>
    <sequence length="1180" mass="138012" checksum="AC2E5957EEC51198" modified="2015-12-09" version="1">MFLKLYLLGAALALMPLLIQPDEDHRKKLFPLVPEDINGTTFLTDLRPTIFSNIVLIKCPYIKYRHKPSNYTFTPDDDILISENIFRDTENVFAWIPLLRQSTNQTRITCGRVNIKIGEEPKIEKQWIFNVIWNKSLIHNVEVEPRDVHTHISRTHTKCTHLEGKSVILSKKKENDVILKVNPDNIEHPYVNQLFYYFVIPENGGIDMLKKPCVILKAYNECPKIILKKHTINTPSNGGNNTNIVKVNGIVEKIDVILKLNDDTNYYRDEEISLSRMKYKDGEPDIIEDSKINSHFFIKGYDLVKLTYNCFFGGIFKNISEKYYFAPLSKDHIIKVNTIKYFKNETSKKPNCPIFYLNVGYLKKINYNGTEGNYQTLESIDGIKGNFNRTESHIFFKENEDGKTTLSCTYKTLDGTIKTTTNFVNEDTIAHLKDLENQIILNEKIQINETANSKVTAMQQALKEKEERMEKTIHEKEKRLKESNMSLFQKLSDKVGKGNAIFLVAALILFILIILAVLIVFVYKKWLSPYLIMLKQKRKYPNVYVFWDTLTSQPFDNYCKAIKEKKYLSNKVLNQIVVKKMEGGEEVDVGVSHLFDQTLVKCYRRFPRKIKAHYIYTDIEKRKYILSDGLTKDTQSTFWQMVYEEDIGTIVAIIYDTKSLDADEYPDDVYWKWKTKKRVFGKVIVTRLEEIKVNALFVTGQKILLEKDGGETKNLEIYHVSNWKENDIPQSDLQFVNMYQEIIKDSQKKNILIHSPEGTGARVYMFTYFACIYDALKTDNDTDCPLKIIKMMREQRYGGNIVPYEFAYVIKALVTNFFNNKILVDFSSRRADFYSSYDTYFYDYLRRQAKMDENVKKFLDFVNIVDEGKIYEYKSVFDTLGRMDPDILPEYSKRFQNAVKNHKEGKDKKRFRYSDIPCIDANGITINGKPEDDKESFIHANKFEYKTVNGTRKLILCQAPTEETSDDMLDMILRYKVSLIVILVKPEEANGPQKKWVPYYPTKHYELDTPNFTLSRIMLNKLDENFIVESRYQVRSKKTNEAVAFNILHYQAWPDTSIPSEHKSVYGLYKKIVSLRTDDYVAIHCSAGIGRTGTLALIMYLIDTINYFPTFDPITRLKCLREHRYLAIQKHNQFVFALLVVFEHYKKEIDEMDDGAYERFLAIAENLFNKEKKRQEKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKW6</accession>
    <name>A0A0N5BKW6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKW6"/>
    <dbReference type="STRING" id="174720.A0A0N5BKW6"/>
    <dbReference type="WBParaSite" id="SPAL_0000656900.1">
        <property type="protein sequence ID" value="SPAL_0000656900.1"/>
        <property type="gene ID" value="SPAL_0000656900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033547">
        <property type="entry name" value="transpos_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="2">
        <location>
            <begin position="399"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000656900.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="77003" checksum="89CAC4F9EF16ABBD" modified="2015-12-09" version="1">NCNLRTCRKKIAVKHGTWFSDSRLEFVTAIRFIYCWSEELVSINFCEKQLQISHNTSVDWCNFMMEMCVGSMEHLEAQKIGGPGRIVEIDESLFSKRKNHCGRVLPPVWIFGGVCRETGECFLQAVPNRGFKTLTSVILERIEEGSTIYSDCWRSYKTSELEAQGFEHFRVNHKYNFVDPESGAHTQTVERMWGSAKWRNKKQRGTDRNMLDSYLAEFIWRKNNRENDLFIKALQDIAALWPPEENDFGMIAEPHATSKIRKYEDLTAIQTYGFRGRALNSLCSSSKLTVLIRAEGNKGYQLGFDNTGKYLPEETKEITKTVGTEVIVTNFMCHSPVRRKALQRKKKAYIDIIINVVKVLQDYALARIDSVFELSHTNNGKTTVLMKTPANNAQMDRVVRSVFPNKGYFLNNNMVKLKDVDISETAYDLYKLSKVKLDLLKVNLVKVEGYISMIENIENYSLDYIFLFVNKRQIKNQDIKAGVKRAYPRICRVCDVLSVMHITIPSIYLDVNSSPLKDQIECTIMDLVLARFYSCVDAAMIEKISPNTCDTRKVRIDDSEGLNISRNRKLSIDKNVNDETFKKPDLSNHSQVPSKFSLKALKEYVKSLSQQETPSTNSYDTEVVFREENEKGAEEELKRYLKKDDFAKVNVIGQFDYTFILCQNIQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL14</accession>
    <name>A0A0N5BL14_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL14"/>
    <dbReference type="STRING" id="174720.A0A0N5BL14"/>
    <dbReference type="WBParaSite" id="SPAL_0000661700.1">
        <property type="protein sequence ID" value="SPAL_0000661700.1"/>
        <property type="gene ID" value="SPAL_0000661700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000661700.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32740" checksum="3B560114AD82848A" modified="2015-12-09" version="1">MVSSLGKDVKVAICSKILLNSPPGELIDVFNSVRGIINDDDLLKNECAPAVAEYNLENFHQVRQDLSNPCLITKYNHLGNDRFLEPQAGVTFKFDHIRREVSDIQPADKLYYSEDLNKWRKVVQVELNKYIEKSYKNSGVGVVFVYDGQLVICIESHQFRPKSYWNGRMKSCWIVPPYDSKTSTIEITGTVKLDTHYFEDGNVQLKMDHTYKPKCVASNIGNMAIEVIKGIGKSEDAYQATIQETYMAQIEEVFKQLRRSLPITKTKFDWNKIHNYKIAQDMGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL99</accession>
    <name>A0A0N5BL99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL99"/>
    <dbReference type="WBParaSite" id="SPAL_0000669900.1">
        <property type="protein sequence ID" value="SPAL_0000669900.1"/>
        <property type="gene ID" value="SPAL_0000669900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894684" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000669900.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16672" checksum="E2217D6C5B95A641" modified="2015-12-09" version="1">MFLQFITFILISEIIVGIPNITNKEVLASADGISCYYFSHGFNNIADTPITKVKCPIHDNCVKVVDQYGSMKGTWKGCSSQYFTANFKKLGAYYVPNTCISGEYIPPNGVTVQETLCGCDNKDLCNSGSKTSILPVSFAISLFFYLKTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLS6</accession>
    <name>A0A0N5BLS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLS6"/>
    <dbReference type="WBParaSite" id="SPAL_0000687200.1">
        <property type="protein sequence ID" value="SPAL_0000687200.1"/>
        <property type="gene ID" value="SPAL_0000687200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="152"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000687200.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42965" checksum="D838FD74FBCFA188" modified="2015-12-09" version="1">MTAPEFFCEEDYGSKYFIGGKITHQWIVDCLEKNDADFRKHKGDSKVKEINGIDISDGKGFTSKVFKTSIYFDDEKKMPYYVIVKIPGEESMKESMEKQNAEDTFNLELDKISVFHNKECHFYNDIASKIKDLKYPKCYGSKDLIAGKQTGVLIMEFLGSDSVTVPFYRSLNIYQTKSVLDEAFKLQEYSLLNQGDLTKINWEQPFSEDIMKSFSDLLRKGMPTLKKYIPKEMWSEIEDDLNKMASNYIKIMKHVFIELPKSNDNVNVISHGDMWTNNFMFKVDSNGDCSNNLSAVFDWQTVFKGTTGHDISRILAICAPTDVRREIEKDYLPVFYERLKNSLIKNGKEIKISFETFMNNYKLCFVDIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM32</accession>
    <name>A0A0N5BM32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L50, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM32"/>
    <dbReference type="WBParaSite" id="SPAL_0000697675.1">
        <property type="protein sequence ID" value="SPAL_0000697675.1"/>
        <property type="gene ID" value="SPAL_0000697675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000697675.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10967" checksum="F6BD4FF8980EC891" modified="2015-12-09" version="1">MALRNTLTRLRCNPYKDDTPYTKFYNDPERLLNKTLELSLDIGTKEEIFSPPLDGYFQRKPDINKQWSKAKILKKLSKHTYLIEDIMVLIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMY5</accession>
    <name>A0A0N5BMY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMY5"/>
    <dbReference type="WBParaSite" id="SPAL_0000726600.1">
        <property type="protein sequence ID" value="SPAL_0000726600.1"/>
        <property type="gene ID" value="SPAL_0000726600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894748" evidence="2">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="112"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000726600.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29914" checksum="20DBC7D8686116C4" modified="2015-12-09" version="1">MLIFYNNYYITLILSILFFRYQALENGARSDDIASLSLVHNDESLRNIIKRDTKIDYNAEVKENKYQRKILAVNNRNNQKKVVKKKASKKDSNKRKPKKDSTEEIIHEKFIHEKFALIELCNEIRRKHHSPELKFSYKLSEEAQKLAVKLLKTKKWKYYKNSKYGVITYFTPNMEIEYTPINYWTKGETNINYKNLEKTIPPDYAQIVWFSSKQIGCGITDKGPKKGSLTVCLFYPKGNIKNKYSKNIYKPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNV9</accession>
    <name>A0A0N5BNV9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNV9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNV9"/>
    <dbReference type="WBParaSite" id="SPAL_0000758700.1">
        <property type="protein sequence ID" value="SPAL_0000758700.1"/>
        <property type="gene ID" value="SPAL_0000758700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057565">
        <property type="entry name" value="WW_TCRG1_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23517">
        <property type="entry name" value="WW_TCERG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="477"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="545"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="455"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000758700.1"/>
        </source>
    </evidence>
    <sequence length="864" mass="102223" checksum="77C9B235B88E2459" modified="2015-12-09" version="1">MRYSPKTLDIRDLKAPQNLHSSAPMTDVSFFNNNAPRPNIRQRGPPTYNAGARLLPTHAAAAYGNNSNPNIIQPPRIGNNNPGPSIMANNINPIEIQEKQKEIFIKLVKERIEYKDGDELWVEISQLGGKPYYFHAFTKQSVWNKPEGENIVIIDQHEFKNIGEEAGRRFSEFTKKSPPTINGYSGGKINQSNNMIYGGTNNLSPMTSSNNTQLDPCIFWKEYFDKNTNRAYYYNIKTTETTWIKPPELVEKELEERRRQEEERKLELERKKTNRAVKTIPVKGTQWTVVWTGNGKVFFHNPSTRQSLWERPPELFHRDDVDQMINNESLTNNKLLNGELFNNENDDIKEDNQDNLKDCLVVDQQTTEEPLAKKKKINNSNDNGIVVPAKLLDDPSVQKEIEAQKTREQLPFEERVRIFKEMMLEKNVSATSIWEKELAKIVNDERYLLLNKDERKAEYDKYVKERLEIERLERKKRHKEAVEQFESLLEEAKLTHKSLYPTFAAKYSKDERFKKIEKTREREEIFNNWVKNIANQEKEEKKKLKHDAKTSFIEMLKEHKSLTRNTKWSVFKKKIDNDSRYFNTYLTSDIREELFKDYIKTLSSYSQSDVEDEDARLDRLKEKSLSQKALEERKKTVEKEKNEMTKDMKHSAGALARDNAKRLWKTILVEKIKKYDISWHDAKKILRDDERYEECDYLSRSEKEKYFDSHIKDLLSKRQKEIFSQFDQDKRFTYASSWSDVKKILITDEIYSNLYSSERKLEKDFREWKDETINKLLGDFKELLRETKIITYRSKRLAEENEQHLLDILSILEKDNRYLILNDIPMKREKIFMEYIEKLDKYGPPPPPTSSESESVKKKDFNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPK8</accession>
    <name>A0A0N5BPK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRA1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000783200.1">
        <property type="protein sequence ID" value="SPAL_0000783200.1"/>
        <property type="gene ID" value="SPAL_0000783200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000783200.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27424" checksum="CB3DEBC2854E808E" modified="2015-12-09" version="1">MPLKHKKDEEEAQLGDDMFTRVQRIDNQRGNPNGTEAVIHSGVSVTNHGQQQQNSYSGQVLQQPLQKPLGQSRPGSSTQQLPYMGHSGMYQNSEIPLDNSPNYLIFSPPHTVMSEERRPITQPDPATYVPPIKAAGDVSLSGNQLVAFLTKATLRLPPGETCKGIQLRIENFNQMIQNNSITDACLKKLNFVVDAIDRDMLEDASVFFDQLMLSFGNEAGQWGHGVKLLINELKRINNDRRLRGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQB1</accession>
    <name>A0A0N5BQB1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoplasmic reticulum membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQB1"/>
    <dbReference type="STRING" id="174720.A0A0N5BQB1"/>
    <dbReference type="WBParaSite" id="SPAL_0000807875.1">
        <property type="protein sequence ID" value="SPAL_0000807875.1"/>
        <property type="gene ID" value="SPAL_0000807875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000807875.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10832" checksum="DF146A91BF0C7039" modified="2015-12-09" version="1">MYYIFIFIQISYFVVDVKEWGSCTNNQEYRKILVLFITLLGFVSKGTIFIELNVSINEECIGTLNEYVLGIADFLYENHACDTCWKFYTEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR37</accession>
    <name>A0A0N5BR37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH rpiR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR37"/>
    <dbReference type="WBParaSite" id="SPAL_0000834100.1">
        <property type="protein sequence ID" value="SPAL_0000834100.1"/>
        <property type="gene ID" value="SPAL_0000834100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000834100.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12538" checksum="B02DB438ECD54E3E" modified="2015-12-09" version="1">MTGNVKKLLIKRGFAKVDEVKGEVAAILKSEPKISIRRLSAMTGSSIFTVWRALKAIKFHPYCMLTIQKLETCDYKKCRKFCMEELENIEQDSNYLMNLMFSDEAHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRK1</accession>
    <name>A0A0N5BRK1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRK1"/>
    <dbReference type="WBParaSite" id="SPAL_0000849900.1">
        <property type="protein sequence ID" value="SPAL_0000849900.1"/>
        <property type="gene ID" value="SPAL_0000849900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000849900.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10988" checksum="7712F0D1D0ABDA0B" modified="2015-12-09" version="1">MFYEKYPIDKRRVRYGNTFYLRGVFRKRKRPKLYLKIFHNCVESNFVGKRKTAITKILTLRVPDQYVGKGTWPSSLYFMGEMDLAQINRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRQ6</accession>
    <name>A0A0N5BRQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF775 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRQ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BRQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000855100.1">
        <property type="protein sequence ID" value="SPAL_0000855100.1"/>
        <property type="gene ID" value="SPAL_0000855100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000855100.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23268" checksum="D2BC83B2758532A4" modified="2015-12-09" version="1">MTSNVFGALVVGRSVNANFEVVSPTNFLCTIQDNTNISHIVVFLTGVEPFPEGYGGSIYMRWASIGNEDPAWHYLGAITNSKPSAMFKVGNLYDKEPTHSNIFSQQNIFTLSHNCCQIGIQVEAESEINQRTATEGVKPSMEGEMTEFCRKMLSNFFNYCQSFVSTVPSGNGFGQNVEVIPAKCLEQWYNKFETRMKNNPKFWKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSI0</accession>
    <name>A0A0N5BSI0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSI0"/>
    <dbReference type="WBParaSite" id="SPAL_0000882275.1">
        <property type="protein sequence ID" value="SPAL_0000882275.1"/>
        <property type="gene ID" value="SPAL_0000882275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000882275.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13050" checksum="7FAF289B32A6CA06" modified="2015-12-09" version="1">MEEKIEENVEASCKWGVKDIDEEKEKLDQNYDKNKKTDVREKNKKNSNNPLVTEKKRAIKKIPMINKIKVKDSTDKKMNSDNAKEEKKKLKHQKMIVKRKIKLLKTVIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTE2</accession>
    <name>A0A0N5BTE2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTE2"/>
    <dbReference type="WBParaSite" id="SPAL_0000912550.1">
        <property type="protein sequence ID" value="SPAL_0000912550.1"/>
        <property type="gene ID" value="SPAL_0000912550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000912550.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8504" checksum="E9B43D8DD84FF417" modified="2015-12-09" version="1">MVFFVKSTYSYVDCDYTKIKLSNHLLNKVSSQKKKNNYKHEEIKYKKHLYFMALKPSICINIWVYNYSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTP7</accession>
    <name>A0A0N5BTP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000922400.1">
        <property type="protein sequence ID" value="SPAL_0000922400.1"/>
        <property type="gene ID" value="SPAL_0000922400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000922400.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26396" checksum="3DFF027F74454399" modified="2015-12-09" version="1">DEKFKSLYQKKKGRNTRIFNTAFDYGSIMMPEISFGSKNGRNAYEVLKSKAYIHMVGQREEFSHNDLKKINDVYCKGLCARKFKGCKHGGYFSSDYCVCNCPPGYAGKTCTKIAKSVGYCGRKKRLFATESKRRLVLKGKKKCVIAIDTRAGRNVALVVEKVETERLLPCVQNKGLEIKYRYDKGATGLVLCGSYRNISIPPTFSRTLLIYHGLENNHEVRISYREVKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTR9</accession>
    <name>A0A0N5BTR9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTR9"/>
    <dbReference type="WBParaSite" id="SPAL_0000924568.1">
        <property type="protein sequence ID" value="SPAL_0000924568.1"/>
        <property type="gene ID" value="SPAL_0000924568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000924568.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14983" checksum="E81352B4B8832513" modified="2015-12-09" version="1">MMSGAHANFMYAGGYHHREFPTPFRKSSVRSSQKRHHRPLSVPSQPIFISFIKFGKSMNSASAVNFMLAGGYQPGGFPMPLSRTNKNRGSSSRGSRNHKTQSSHRSKQGQVKKKGRLFGWLNRKNRSNYQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU27</accession>
    <name>A0A0N5BU27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU27"/>
    <dbReference type="WBParaSite" id="SPAL_0000935000.1">
        <property type="protein sequence ID" value="SPAL_0000935000.1"/>
        <property type="gene ID" value="SPAL_0000935000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000935000.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38385" checksum="616893816498D637" modified="2015-12-09" version="1">MDLPDLLKTLCQIKLFEDKDAASFQIYVLNRDYFKDFKFGTLTREIAVKKVLEDINIKITTQFQEFKLDGKHFSSTPKITKENRSFNPPTIHSDDVTTEIDKLGSTINNSDYSTLLSQVNFNGDKKPLPNNSIVALPQTNNYNPNDNSINILSVSTAQLPNIIFVNVESDNDIQKLKSNTDTAIDIFEVNSIFAYTYGLKIGEKIDVHKRKFPSNYKTSAAHFSAILSFLKQATIKSISNLNVFTDSDIVIKYFKSVAGVSNEVFNKSTEAAKRYFDEIQLKLKKIQTITIAYILNPKVKTLLDVCKQISLDLKNDFKNEKTNESELSLNVSMDNRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUT2</accession>
    <name>A0A0N5BUT2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUT2"/>
    <dbReference type="WBParaSite" id="SPAL_0000960075.1">
        <property type="protein sequence ID" value="SPAL_0000960075.1"/>
        <property type="gene ID" value="SPAL_0000960075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000960075.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9504" checksum="E79BB61EDC266E3F" modified="2015-12-09" version="1">MAKRKHTIISKEGNKAASDEKDISTITESSFYENIEQESNKSSNSSINSNDENVDSKKRRRGKCTTENNKIKKEEIVEAAVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUV8</accession>
    <name>A0A0N5BUV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000962600.1">
        <property type="protein sequence ID" value="SPAL_0000962600.1"/>
        <property type="gene ID" value="SPAL_0000962600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000962600.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20058" checksum="5FA36E136E49F278" modified="2015-12-09" version="1">MASEFIRRKLRENPEIARKIKDNLEDQLRLQRHREHVEKYRKCVEMLGQKLMYEVACIRSAPPTHYIFSSTNEKNKEEKDGGEKKNKKEGGGKKNEGEGGEKKNEREGKENEGEGKENEGEGKKIEEEEKRKKSEEEEIEEDEEERKKSGDEEKNSGEKKKGGRPKKKGSTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWA7</accession>
    <name>A0A0N5BWA7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWA7"/>
    <dbReference type="STRING" id="174720.A0A0N5BWA7"/>
    <dbReference type="WBParaSite" id="SPAL_0001010700.1">
        <property type="protein sequence ID" value="SPAL_0001010700.1"/>
        <property type="gene ID" value="SPAL_0001010700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000045">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000077">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000303">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733536" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="341"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="390"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001010700.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55102" checksum="CB33FC7A304B3354" modified="2015-12-09" version="1">MRLLFSVFAFSCFVLTYGSVVELTDSNFYNRIEDFEVALVKFYAPWCGHCKRLAPEFDKAAIKLKTNDPPVTLVKVDCTVEKKVCEDHKVQGFPTLKIFRKGVLSSEYEGPRDADGIVKYMRGQSGPSSKELKSVAEYEKFIADEDHSVIGFFESESKLKDSFLKVADTERDRFRFGHTSDKALLEKLGYTDDIVVFTPKKLQNKFESHEHKYDGNYDTDKIKNFLIYESTGLSGIRTQGNLFQFTRRPLFIVYYNIDYVKDPKGSQYWRNRVLKVASEFKRKAYFAVSAKEEFGDEIESIGLGERKESDKPIVGALTKDGKFPMEAEFSVENLKNFVQSVLDGKVEPYMKSEPVPETQGNLKVAVGKNFKELITDSDKDVLIEFYAPWCGHCKSLAPKYEELADTLADENVVIAKMDATANDVPPMFDVKGFPTIYWLPKDTKIPVPYNSGREVKDFINFIASKSTDGLKGYDRAGKKKKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWC3</accession>
    <name>A0A0N5BWC3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWC3"/>
    <dbReference type="WBParaSite" id="SPAL_0001012150.1">
        <property type="protein sequence ID" value="SPAL_0001012150.1"/>
        <property type="gene ID" value="SPAL_0001012150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001012150.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12677" checksum="5DEB2EF8BD365A5D" modified="2015-12-09" version="1">MSKNLSLNKKIFLTRNTMIDFSFQNLYYFTIHVSSFWFLNTIILYLLHCTNRGKGSSQNSTNENDVQLKNINQMTSVKVLNAKDTYRTLKNKQYNEKKKNGVGEQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWL7</accession>
    <name>A0A0N5BWL7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWL7"/>
    <dbReference type="STRING" id="174720.A0A0N5BWL7"/>
    <dbReference type="WBParaSite" id="SPAL_0001021100.1">
        <property type="protein sequence ID" value="SPAL_0001021100.1"/>
        <property type="gene ID" value="SPAL_0001021100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="188"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001021100.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="52001" checksum="6FC4925D1A243DBB" modified="2015-12-09" version="1">MEETRGEPSNISDGLHKYMKISAKSILLENSICCVCGDKGVTKTYGDILCRGCTDFFRRCLEKNPQLTCKLKGECEITKESRAKCRYCRLKKCFDCGMKREIWEKNKMRFAKNLKNNNFNKENSQNKLLVKIAEIKTPPVYLTGTTAMKIKTDVSPTNTTEMKIKTDVLEKDKNKPVKSSSTQIMSQPKESILNDLIERENIMKHPKRWHCYNSKVFFETIKDNGETVYSGGVLKPLNEMLGSTIQWTEAVGKFINLKISDKIFLTEAFACKSIILCLMYRAMDNENFIYMTEKSIDENYDESDDKRIFNKFFGKKLRELVNKMLRLNVTYVEFIFIKATLFLNNNVDGLSNDGSISVLELKKTILESFIKYKNNDSLSCLLRLYDLLCSISPLLDILSKMIMKNKILRDVFNFDNAGVLIQQYIGEPSVTKEDEINERITTEDDFMVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXI8</accession>
    <name>A0A0N5BXI8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXI8"/>
    <dbReference type="WBParaSite" id="SPAL_0001051550.1">
        <property type="protein sequence ID" value="SPAL_0001051550.1"/>
        <property type="gene ID" value="SPAL_0001051550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001051550.1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7453" checksum="1D07D09983C12D5C" modified="2015-12-09" version="1">MHSYSYYPYYIITFSLGYCNEILYGNNNDNRIYISIAYNHESKFYFCRFDEILRIHNFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXK8</accession>
    <name>A0A0N5BXK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4536 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXK8"/>
    <dbReference type="WBParaSite" id="SPAL_0001053266.1">
        <property type="protein sequence ID" value="SPAL_0001053266.1"/>
        <property type="gene ID" value="SPAL_0001053266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001053266.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12305" checksum="F07E26666CB566A6" modified="2015-12-09" version="1">MKPSPNLSASFQTIKSAGGWCKYKCCFTGVAALGLMALAYYYYTKSNSQSTNNKGIQKKLASAGVALGIYLVYKMSNNNCKKPSDNIKIEEPNEYCPSSAEGCFTSNQIPFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXL5</accession>
    <name>A0A0N5BXL5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="18">DHPDHase</shortName>
            <shortName evidence="18">DPD</shortName>
            <ecNumber evidence="18">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXL5"/>
    <dbReference type="STRING" id="174720.A0A0N5BXL5"/>
    <dbReference type="WBParaSite" id="SPAL_0001053900.1">
        <property type="protein sequence ID" value="SPAL_0001053900.1"/>
        <property type="gene ID" value="SPAL_0001053900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 18" id="KW-0274">FAD</keyword>
    <keyword evidence="7 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 18" id="KW-0288">FMN</keyword>
    <keyword evidence="15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="961"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="994"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001053900.1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115797" checksum="34267D7E5F2BF5CC" modified="2015-12-09" version="1">MAPQNIEKFSQDTPDIEAILALNPRVTTHAKAIPTIETKKNKLDWKRNSPKGCNTKSCNNGSNPYEKDFRDIKHTTLSERAALRESARCLKCADAPCQKSCPTSLDIKAFITSISNKNYYGAAKQIFSDNPLGLTCGMICPTSDLCVGGCNLAASEEGPINIGGLQQFATDVFRQMNIKQKLSPEIESSTKDDPSYNQKIALIGCGPASISCGTFLARLGYKDITIYEKNSDPSIIGGLSTTEIPQFRLPYNVVDFEIQLMRDLGVKIVSGRSLHSSDLKVDKIKEELGVDALFIGIGMPEAKRIPIFENLSIENGFYTSKDFLPIVAKGSKPGMCTCSSSPLPNFVGCRVLVLGAGDTAFDCATSALRCGAAKVTVVFRKGFTDIRAVPEEMEAAKEEKCEFMPYMAPRKVNTKDNKIYSMSFVKTEQDIATGEWYEDEEQTLTLKADIIISAFGSTLIDKDVISALSPIKLNRWGTPEVDYKTQSTSEPWVYVGGDFGGIAETTVESVNDGKVAAWNIHKYLQKQFNVDVSSKPQLPLFYTSIDDVDTSVTLCGIKFENPFGLASAPPTTSGPMIRRAFEQGWGFVLTKTYGLDKDLVTNVSPRIVRGTTSGHMYGPGQGSFINIELISEKKMAYWLKCIEELKKDFPTKIVIASIMCSFNKQDWQELAIASEKAGADALELNLSCPHGMGERGMGLACGQDPHMVENICKWVREVTTIPFFAKMTPNITDVRKIAQAAKDGGADGVTATNTVSGLMSLKSGDGTPWPAVGNEKRTTYGGMSGNAIRPIALRAVSAIANAIPGFPILATGGIDSADAAVQFLYAGASVVQICSSVQNQDFSVIGDYITGLKALLYLRSNENLLRNGWDGQSPPILKHQMGKKVLVENTKLPNFGKFKEEKKKIEKDFIMNQNLTEKVDEDFTTRETYKEPTKVATVNEIIGLSLKMIGSYNELTNKEQKVALINDDMCINCGKCYMTCADSGYQAITFDPVTHIPCVTDDCTGCTLCYSVCPIPECIQMVEKKIPHKIKRGYPMNSYEILTESVNGKIILNPNNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY17</accession>
    <name>A0A0N5BY17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0585 protein C16orf13 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0585 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY17"/>
    <dbReference type="WBParaSite" id="SPAL_0001067800.1">
        <property type="protein sequence ID" value="SPAL_0001067800.1"/>
        <property type="gene ID" value="SPAL_0001067800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974:SF0">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001067800.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24201" checksum="5D87CDACD11E0CB6" modified="2015-12-09" version="1">MLQNAAASRNCKPIVEVLKNYISPEDNFKVLEIASGTGQHILSFAKNFPNSTFQPSEVSHRYLHSIVAYLDMLRNAHSMISKKEINIRVPLYIDVSKAPTKWAMPQDYGPNEIDVMISINLLHICSQDAVIGLFRAAGAFLKQNTGKLFTYGPYAIDGIISPQSNVEFDISLKEKNSEWGLRDITDLNAIAEKFGLKLINTHQMPANNYILVFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY74</accession>
    <name>A0A0N5BY74_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY74"/>
    <dbReference type="STRING" id="174720.A0A0N5BY74"/>
    <dbReference type="WBParaSite" id="SPAL_0001073600.1">
        <property type="protein sequence ID" value="SPAL_0001073600.1"/>
        <property type="gene ID" value="SPAL_0001073600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="381"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001073600.1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="119238" checksum="107E002632295012" modified="2015-12-09" version="1">MDLESKKDKRVEKFEMRFPMMEVLRFDKYHEENIITFASLEKDDIMDDLDKVSIILEKLSGELKKKLYLMKSPEDIIKMCWSSKGITEGLKELLLREFGGFQNPLVRFIELMNGDLDSDDPEDALTELQTKYAVLKPKLSDDKVLIGMFMNFLEKSNSTLCMEIKEVFREKIVKQQFTEVSADKTDKIAKVAKLEFQNKNGSFNKTRKVDYKRNQTYFRRNVTGNSEIICYKCNGKNHLSINCNSKFGLNVTCEECGGKGHYTNNCPNVKKAVKKLHSKILDDSGDVAIDDENKDFEDYSGVPSFRINKLARRDFIYETKWVPKFVSSLEKKQQIDLVSLFSDIENVKNYFVKLFSGGIGLVPHEFKLTLKENIKPVFFKTPRNIPYALVEATKEKLREMERENIIEKCYNPTWGSPIMVVQKTNNMDDKIKVRITGDYSCTVNPFLEDFNSIIPDRESIFCKLQGNYYSTLDLSDAFWNIGIEKESRDLTTIVTPWSCYRFKRLPQGLKVSPLIFQCYLESQLNPDMLEEIVIYQDDIIIITDTLERNRQLVFDIMTKLESLNLRLSKDKLLLFKKEVKFLGCWISAKGRKICTERYNHFKALKFPETLKDLETFQGLLSYFASYLVGLYKFKECFELEKVKVKNNKIIPTTMQLEYFAEITKQLSSDNAVVHYSLKEKLLLACDSSENIMGATLFHVYSDNSRKPIISACKTLTSFEKKYDIASKEALAIVYFVQRFNQYLRCRKFEIECDNRAVTCIFQNNKNISKLAAKRIARYRLILSHYDFSIKLIRSKDNVLPDALSRLIDMDKVELFKEEEVLVSALSDSNHKNEFMLLKEELPSSVNISELIFISNEDEVVNKVKGILSGNGNWDKKSRNLEEQFLLKNRFNLDVLDNILLVKNVPYIPKNFRLKLLQDIHGMEHYGITTMLELSKKFEFPLKKEIISSFIKSCNICQKSGKKPKFVSDKWPEALYSFHRCHIDYLKYDGKDIILLVDAYSGWIAAKITNKSSSEETIEFGFLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYM8</accession>
    <name>A0A0N5BYM8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BYM8"/>
    <dbReference type="WBParaSite" id="SPAL_0001088000.1">
        <property type="protein sequence ID" value="SPAL_0001088000.1"/>
        <property type="gene ID" value="SPAL_0001088000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="643"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="1265"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1111"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1126"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001088000.1"/>
        </source>
    </evidence>
    <sequence length="1540" mass="176656" checksum="3EA7B08AD79A3AB7" modified="2015-12-09" version="1">MTENFDEEKPEVKNEIHIVLDKETRLQELERKLEEKLADLERREENIKKMENEVSRLSKLYSEKIGNFQSSIDLDKSSLSGINHQQNAYANQISTSKEPAMSMLRTQEPGGTPMLRNKRPVFNTLLSTLTSLPNENQTPYKSVLRTQNLNNCLSEIRSEIPRSMETETIKSYIDEIQNPRHQSTPIFKNSHEETKKKTLFANSFTAGYQMKQFTLEPFKGKEMFASYLTRFEAMLNINMVPESLFTATLIMHLESLPAEKVNMVFNIYSPYNKIVDFLLEQFKGTESVESAKQELRSLCNVKIEKIIDVAKRIDKLVDTAYARESIDDRLIKKRKYLADLIKSPNVANAIEYQSSGETFEITIWKARNMLDRELKSNIINRGNGRPKGREKCNHCGYTNHKSEDCRKVNHGLNRSNFKRDNYNKQSKQEVNNILESNNIITDMCEDSSSHLRIITVAINNLIKVKALFDTGSTKTLIPKNLATKIGILSDLSKPITLKTLSFGKSLSAMKTKMPLNFKFDKQSLTKKVYITDVSLDDRSYDCIIGWDLIKRLNVYEKFIKNAKIDDEVNVVVKESVPKNCKFLDDLKFEYSDVFAISEFDLGEGLISCSEIELKPGGVFKKPIHYPIPESFMSQFKHYLNELENAGVLIKMDTIYTHPCIILQKENNILRMISDMRSINNMVVPHYHAAPTFKEILGKLNSSKYFTKLDSPNAFFQISVLPNSVKYLGIRTPFGTYCYQRMPQGFLNSSSEYQRLCENMLKNIDGVINYIDDIVVYGGDNEEEHFEIVKKVLQCFRQNKLKLSFDKSTFCGSKIQYLGYEICSLGSKPARKNIEKFLSRKKPVSKGEMKSLLASSNYFRQHIVSYSKIIYPLEEALSQKYKRLNWTSDMEESYKLLLSTMNGDNFMRHPNFNVPFNLITDASQFSIGAIVTQIGPDNKEYLVSTYSKRFRPGKTEQSATWRELVGVVKSFKHYRSWFVGNLVNIKTDHGPLVGIFSHTDDPRYIGQIAQMQGFHYNISHLKGAHNPADYISRYILTPTTNTFSCPQQYTLDTFIQPEVRNLHYVSNTDDSDSCLESDNSLSSTTTSSIIDNIIVIENNAITRAQKLQNSSDINAIKRKRGRPKKQLATNTTNVPSKSIENDNVNPIDAPQYKVINESQKRRGRPPKSKYIPDDIIDVNEPSLENFSNFSENKGVDSDDLNLHEVFEITHNSGHPGLDKMVELIQLRLPNVENLRGKIAKYLSTCLTCKLRNSGMKRVPPPEAIDQYDCPGQCYSMDIMGKIKPPSDNGDCYVVSVIDNYSRAITLFSLKNYDAETLIPILHKKVFMIRGYPKDIKTDNGTNFVCSKFKKFLQNLNINHITSNAFHSRGNSQCERSFKTISDIIAKICRRLPTTWADTLEAVQFYVNSTISKSTGVSPFYAEHRRHPNTLLDQMLKTYSSGVHDTSKSLFDLYKHSAIIREEIYQCLKETRTEENSKLPFKPVLKFNAGDEFFIRSSDKDSNKFGYRYDGPHKVIRDCGTFLIYKIGNLERTVHKQNVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0U9</accession>
    <name>A0A0N5C0U9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gag protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0U9"/>
    <dbReference type="STRING" id="174720.A0A0N5C0U9"/>
    <dbReference type="WBParaSite" id="SPAL_0001162700.1">
        <property type="protein sequence ID" value="SPAL_0001162700.1"/>
        <property type="gene ID" value="SPAL_0001162700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001162700.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46750" checksum="203A44606A28A14E" modified="2015-12-09" version="1">MKKLFKRTMEIEPNAAFKTTYNVLTTKWKQEQKETRNLPQIEQEKVTNRQRKELQSLFEEYGIDMVKFETQYPLPLLTNADIDLDIPTHEKELDDVFRKEIGKVIPLLRDFTITGLEKYIKTLEKALLSLAKNPIRYAALDRIAGPYLPALLRKDRGMVTSYYNLFLNRNGGAHATLLETLEGMIILMEEDGHRARLGAMAQPPRQGDSAIGSYIQKFNDFVSRIDGIRMDSLEMATNIPLRNERRRQFVNGLQDALRKNVTQPDYEAEWHAFTQAYIAGFTRLYPNQPLFGIQKTGKFQPFSTFRDQRHQQRHHQHHNHNNANDNRFRRPISTNQPPKFLNHRNEQMKPRGYNNGFNRKPQFQKGNPPSSLIKKIHNVETELSRQSALLNTISTKLSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0V8</accession>
    <name>A0A0N5C0V8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2185 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0V8"/>
    <dbReference type="WBParaSite" id="SPAL_0001163700.1">
        <property type="protein sequence ID" value="SPAL_0001163700.1"/>
        <property type="gene ID" value="SPAL_0001163700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001163700.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11820" checksum="5743DE376EBDB59E" modified="2015-12-09" version="1">MKFGNDVKLASYFYVGFEKIDKNEKFIIQLTPKWNDKYSFNVAVCPGKEWLSNYSSTEYIVDKNNILDLPKNKYHPFRYINKIIYCHDNHLANKFENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C147</accession>
    <name>A0A0N5C147_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C147"/>
    <dbReference type="STRING" id="174720.A0A0N5C147"/>
    <dbReference type="WBParaSite" id="SPAL_0001172600.1">
        <property type="protein sequence ID" value="SPAL_0001172600.1"/>
        <property type="gene ID" value="SPAL_0001172600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000238">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000337">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001172600.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21933" checksum="78FFB65D93331AAB" modified="2015-12-09" version="1">MRYYRGARFNQRRKLYENAMALGARCAQNVNVMQYSEEVIKQLTPEEIEEFHEAFIMFDKDRNGTISTKELGVAMRSLGQNPTEQEILEMINEVDIDGNGQIEFPEFCVMMKRMMKETDSEMIREAFRVFDKDGNGVITAQEFRYFMIHMGMQFSEDEVDEMIREVDVDGDGEIDYEEFVKMMSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C238</accession>
    <name>A0A0N5C238_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DCB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C238"/>
    <dbReference type="WBParaSite" id="SPAL_0001205100.1">
        <property type="protein sequence ID" value="SPAL_0001205100.1"/>
        <property type="gene ID" value="SPAL_0001205100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001205100.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36126" checksum="A991B7F776A690EA" modified="2015-12-09" version="1">MEGIFEKLGPLIDQTTTSNILVKGYYEKAKDTIKKSHIPVETKRGDFLIFLSQCLINGKNRLSHVAFEGLQYIIQDPTYSSDYSTKKEEDTLPSQLVRNFQKMPEWDKQIQCQSLTLIMQLFSSPNIRISSGNIDECMQLGIKTYLETDESSVKLAVRGAITQIINSFCLNKYAKTIPGNQDEIAIFMEMTALMKKFINRLKTEELVVDEIILLLDAIYSLLSVQPIGVCKHKPFLNALDEDLGTLIKRMFEWCSPKRSKQGIQLPSILGSEKSCTKVIVPDIFFSNEMVSSLYQVVEHLIRIYSKNENCQDILNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4Y2</accession>
    <name>A0A0N5C4Y2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0001301050.1">
        <property type="protein sequence ID" value="SPAL_0001301050.1"/>
        <property type="gene ID" value="SPAL_0001301050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001301050.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36595" checksum="116E393443BA99AD" modified="2015-12-09" version="1">MFPPIADLCILIIEAISLILYLIVTIFMIQSLNTSQAFHTSFIILFVFNGIYGFLSFIILILFWYFPKWGLFMHYYASNEWLSIIYILTFYQFQTLLIIGNVILTVNKFFAVYEPIFYKMCWTKNASYIIVIFQVVVTYLYYSYLYFIGAIFVGDVDRAYFTKSEWKYILFDKIAFCFICWFSTIIMFILTARIGLKFNKYIFKNNESTLLTKFQSFLLMSVSNLILFSLSVISSVTIYATAIDNDDTRLRMNNHTSRILPLLACSAPYCLILSTKGFRDNFWHFLKCSALKNKQSKTIVTAYFSKKNVAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C573</accession>
    <name>A0A0N5C573_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C573"/>
    <dbReference type="STRING" id="174720.A0A0N5C573"/>
    <dbReference type="WBParaSite" id="SPAL_0001310100.1">
        <property type="protein sequence ID" value="SPAL_0001310100.1"/>
        <property type="gene ID" value="SPAL_0001310100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001310100.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23557" checksum="315FDED170DA6DA3" modified="2015-12-09" version="1">MDVKTAVETKTITLQGSAQIVKDLFYYSINNILFQREIYPSDTFCRVKKWNVTLMTSTDKKVKAYLDSLLKQIEVWLATKELKKLVVAIVSVESNETLEKWEFDIETDNEISVDGPITSKKYDEESVRNQIGVVIRQITASVSFLPLLKDRCVFDIMAFTGNSTVPNSEWEATKDRVIKNAETTVFRDCNTGVHNVKTKVQYQVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5I1</accession>
    <name>A0A0N5C5I1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C5I1"/>
    <dbReference type="WBParaSite" id="SPAL_0001321100.1">
        <property type="protein sequence ID" value="SPAL_0001321100.1"/>
        <property type="gene ID" value="SPAL_0001321100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001321100.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="26173" checksum="BC6E5603747C3294" modified="2015-12-09" version="1">XALLETKFAELEHTEEQLDQWTQENLYLSESGDNRRTVKLEEFLSKEIEKRKIDDLSSSFELSFRHTEEESDKVIKTEIVDKEEEDMSKAWTEIDKFEASSGKSIKPMLERLKIAFEVDGTNVDRMKINLLKLKVCDDTLKFIDNLEEDKKNTFDNLAAELLNKYEGKVQLTTAMLMLRHFRIKNNPTTFRKECEEFGKLLDQCYNLKESEKIARLMSIVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5V9</accession>
    <name>A0A0N5C5V9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5V9"/>
    <dbReference type="STRING" id="174720.A0A0N5C5V9"/>
    <dbReference type="WBParaSite" id="SPAL_0001333500.1">
        <property type="protein sequence ID" value="SPAL_0001333500.1"/>
        <property type="gene ID" value="SPAL_0001333500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333500.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56940" checksum="8F83C20FC3E260F0" modified="2015-12-09" version="1">MIGIVLITIILIIYLFNFYRKVKSLPPGPMPFPIIGNLFTFDFEKLHLWICDQKNIYGNVFTIWIPEPLIVLADYDSINEALVENGDHFLGRNVNGYPDKVFHEKINVGVMFSEGEEWKDQRRLSLHILRDFGVSRTILQDKIHLVVQDLCDHIDNLENKDNCNIDKILQLSVGNVINQILFGIMYSNVENNEFFEFAKALEEFGKSVCTLEFHLLLLFPSIDKIPILNSYLYKRITKRQRKMRELCKLQVEKSRKTYNPDNDPSNFIHAVLKEIQSTDSKYSYLNSDHLEGMVLDFWIGGVETTYTTLKWFILIVMKHLDIQKKLQNEIDEVIGKDRLVQLSDKSELPYMIAFINESQRYANIVAFSPKHKCTKDSVINGYLIPKDTIVEPFYWGANIDEKYFKDSYVFNPNRFLDDEGNLKIEHEHMSFGKGKRICAGKTLAEAEIFLIFTSLLQKYEFTHPNGPVDTTPAFSGVLAPKHYTCKIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C612</accession>
    <name>A0A0N5C612_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C612"/>
    <dbReference type="WBParaSite" id="SPAL_0001338800.1">
        <property type="protein sequence ID" value="SPAL_0001338800.1"/>
        <property type="gene ID" value="SPAL_0001338800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001338800.1"/>
        </source>
    </evidence>
    <sequence length="51" mass="5877" checksum="4F0F51655767B123" modified="2015-12-09" version="1">MYPTVQASENPLLDGIVEIKYEKHPENIINKTIYKDEDCKDGIEFPSASEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6L8</accession>
    <name>A0A0N5C6L8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel subfamily K member 18</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C6L8"/>
    <dbReference type="WBParaSite" id="SPAL_0001358400.1">
        <property type="protein sequence ID" value="SPAL_0001358400.1"/>
        <property type="gene ID" value="SPAL_0001358400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF61">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="780"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="850"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1401"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001358400.1"/>
        </source>
    </evidence>
    <sequence length="1470" mass="169438" checksum="0CB26B6EC3EF77B6" modified="2015-12-09" version="1">MAKINHGISIDIEDKESLNNTKEDEEKTKIINEEYSEDNLSYKKSSKKNILYRLLNRFKNLIYQLKFFLLIIIYSIIGALLFIYIEKDYDLASKQESYNYHLVARDMLFHNLKQIHIENKNDRENRWKEAILEFETNINASPPSLETSWTFSMAIFYAGTIYTTIGYGNIACATTIGRIVSIIYAFVGIPIFLIILNNLNEFLLKKIKTISIIFEDIVFYYSIRFGLLKLEGEKRVLHYKKLKKKNNFENLIENELTEFPKVPENNDTYIKIEVEEEEKKIIHDPPILTGVFVTLIWIFLSAGLFCLWEDWTYGSSTYFIFISLLTIGFGDIYPVNKPELFCWAFGAVIIGLSLVTVCISLCQEKIELLYKAILDKLLEDYIKALESGDPNAVKDAMSNFGGKAKFIMPLISKSKGLKMMEQLKSDAKEKGIDLPPSISSVNPETGRPTFCDTNKDKLDNLIKNEKLNNEKRPLISKNQHEKEKTMTNDYIKNNRRDNNYNSTNKISSIINDNIIQTENKRINNSNVVSNAKVLTTSRSAQTNGVLLQDCGIQPDVSYIVKHLNIKNNELENIKNNEELKCKNIISYDENIYVNFMKDTASDPIDVLTYKNTTAQTQDVTLKSRRSQTRFTGIVKTRRNIKDHHNLKEYELQKNKNMKKRINNDGITKKEKRHLKKFLLKIRKDNDNKEKVIDNINGNVDKANNLTNQSETILLMKELERYRLINNIYTCDNNDVDVYDYELKSEAQQFEVLKNISLDFKDYSNKNKEFCDESNLNIGSPNLKNSDLTDDSKNNDVQTFSNAPTPTIQEENSSILLDNQNESYQFCNKHPSQLENVIFPSHLNNDNLKIKVGESTDGHNDDNNTNIKLVGDVSSKKPNNKTNETSSDGEKYEEVTINIELTKKLKHEGYKLITNKEKDYIMKLAGATDFLYDDSSDSDEFIDNTKMDQLRKLHDKFSSEEDNLSIEELFTDKWSQTINEFELKKPKIVLEEKSCQFDKTIELSNLIEKICQTDNKDVKNNDTQTPIYKNHSIQCQTKTNDLHNVECQTKLELTDAFTQEPYRDPEIFDGIYIRDIGIQASCTYGNFTSQYNYEATRVDSQTQHISNTSDFGSQYIYKPNTVSTESQIKVDCLDFNSQYIFKPLKTDSEVQVSCRKKEKNTQTEVKFYEDQAVQFTLEQVNEETQVGFDDGIISRNTSLKNLTIREVECIKEGAEDYLKFPIKNDNKEDTPSLIKFTLFNDNLTTSIKSKKCENDFIETEEKNNTFSSCSSHLSDIIDKDFETQHFQSEIKVQHFNKKLEFTNFGEDVANNSFKDELCREERNFSSITSNVKTENKNVKNAENVVDVGIQTGVLARVQHIYGDGQKMIGTNETVNTPPPEFQKVNLKKLHAIDDKGVYRSVDVTPPASPSSYSIKKKLSLKRDRSSKTSSDSVRSLTKEVTVPDLIRSFSTYEEHEDLQLSTKSDPSKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6P9</accession>
    <name>A0A0N5C6P9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DBF4-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6P9"/>
    <dbReference type="WBParaSite" id="SPAL_0001361500.1">
        <property type="protein sequence ID" value="SPAL_0001361500.1"/>
        <property type="gene ID" value="SPAL_0001361500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001361500.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="35190" checksum="C8E578AA62A2F165" modified="2015-12-09" version="1">MNAFSYSRNNIKRNFIGKKNQINLTNNYRINENIVSQNVLSERNLKSISLSKCGDQNNCFLPVNFTVKEKFIFLEINEAKLLNKIKEQIMSLSGKCVTDLDNTETSNLTVSLIVTDHSKIIRNITKKERSIYLPSSLLKIKNVNNIPICPAHYFHSFLTTELMKKKQAICKAPISSNIIFLTNNFIKIQQRQNIERIKFCQKETIDEFVKLNVFNNFLLSAFTIKTTKSLKYNRKKKFLKYEGYCEFCRIQTVNRFIHCDDKYHKYRISLNKQLFEELDREVGFFDDNFKNDLLYKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7F5</accession>
    <name>A0A0N5C7F5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7F5"/>
    <dbReference type="STRING" id="174720.A0A0N5C7F5"/>
    <dbReference type="WBParaSite" id="SPAL_0001386800.1">
        <property type="protein sequence ID" value="SPAL_0001386800.1"/>
        <property type="gene ID" value="SPAL_0001386800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000524">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="147"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="405"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001386800.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="55495" checksum="634D42AD8244309B" modified="2015-12-09" version="1">MYESSLISVYTFTIMVPSLDNSNTPSNYLIFECSIESMDKNCNCKIKYMGEEIFTKQFSEFQYIYNSLKPGITSIVPTPPKKKFFSNINKVYEKRKFWIENFLTILVNNYASLDSVQAFFDGFLGDESKNHIYLGPSERKTARPDDFDIVKTIGKGSFGMVFLVQHKKNHKIYAMKVLKKEQIKKRNEVRRVMAERNVLKANINHPFLVSLHYSFQTKHKLYFILDYLNGGELFFHLQKERSFSETRSRFYAANIASALGYLHENNIIYRDLKPENLLLDKYGYVVITDFGLCKEGLNKNDRTDTFCGTPEYLAPEVILKQPYNYTVDWWCLGVVLYEMLFTLPPFYSRNVDEMYKNVVNQPLYVPAHGSAVSRNILTYLLQKDPSMRLGAIKDFDEIKNHPFFMPIDWEKLLKREIKAPFIPKLKDDYDFSNIDSEFTSISPNISSLIPQGTLAQSCKDLDFINFTFTEECLNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7F9</accession>
    <name>A0A0N5C7F9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SGF29 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7F9"/>
    <dbReference type="STRING" id="174720.A0A0N5C7F9"/>
    <dbReference type="WBParaSite" id="SPAL_0001387200.1">
        <property type="protein sequence ID" value="SPAL_0001387200.1"/>
        <property type="gene ID" value="SPAL_0001387200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="143"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001387200.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32801" checksum="3682F96CEEE2D898" modified="2015-12-09" version="1">MRNKKLIGNCQSDTSSEEMDETEDTEVIENLISSFTKFKVKRKEVGQKIRKNFNGEGDDMPNIQDVKEFSRCYDITYNIAMTLIDKMSKSAFEIFKYAAFEVPNIKPADFLRSLNLYGELLPPYIPKCHDPVIEGVGGYPFADNSILKEEDLVAGYINKVLCLGMVKQCKVNERYPENSKYYIVDVEDRRKKGQWFLRGELYPLPKYKADPVCHRHAIFRKNTRVLAMYPQTTCFFNAIVLKKPKRSKDKYTLIFENDAQKDDWSEPMEVPQAFVLPCKQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7R1</accession>
    <name>A0A0N5C7R1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Malonate-semialdehyde dehydrogenase [acylating]</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7R1"/>
    <dbReference type="STRING" id="174720.A0A0N5C7R1"/>
    <dbReference type="WBParaSite" id="SPAL_0001397200.1">
        <property type="protein sequence ID" value="SPAL_0001397200.1"/>
        <property type="gene ID" value="SPAL_0001397200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001397200.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="56188" checksum="CE54D026332025EE" modified="2015-12-09" version="1">MLSRFHIVSSRSINLTRPVSVDTVKLWIDGKPVESKTSKFVDLTNPATNEVIAKVPLATQDEMLTAVESCKKAFSTWKNTSVLTRQQVFFNLQALIRRDMKKLAANITLEQGKTLPDAEGDVSRGLQVVEHACSTASLQMGETMSNISKDMDTFSFRTPLGVTAGICPFNFPAMIPLWMFPLATVTGNTMILKPSEQDPGCTMMLVELAKEAGLPDGVVNVIHGTHDSVNFICDNPDIKAISFVGSDQAGTHIYQRGCMNGKRVQSNMGAKNHAVIMPDANKETTINQLVAAAFGAAGQRCMALSTAIVVGSTKDWINIVAEKAKNLKVGAGHENGVDVGPLISPAAKERAVKIIESAKKEGANVILDGTKCTVNGYEKGNFLGPTIITGVKKNMTCYKEEIFAPVLVVMEVDTLDEAIDIINTNKYGNGTAIFTTNGITARRFTNLVEAGQIGINVPIPVPLPQFSFTGNKGSFLGDANFYGKAGLNFYTQWKTVTQFWRSEDATPEAKPQLAFPQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7T7</accession>
    <name>A0A0N5C7T7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7T7"/>
    <dbReference type="STRING" id="174720.A0A0N5C7T7"/>
    <dbReference type="WBParaSite" id="SPAL_0001399900.1">
        <property type="protein sequence ID" value="SPAL_0001399900.1"/>
        <property type="gene ID" value="SPAL_0001399900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000121">
        <property type="entry name" value="Transcription factor IIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001399900.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62204" checksum="E9942F5BE682E89F" modified="2015-12-09" version="1">MVRTCHHCGSSEIDEDSSRGDTTCMNCGTVLEESIVVSDVQFEERAGISSLVGQFVSRDRAQPNSLSGIHGIGSQESREQTYLRGKKIIDEIASQLRINQMQADMAFNFYKMCVNRNFTRGRVRSHVVTACLYMACRLQNTAHLLLDFSDVTQVNVFDLGRTLNFVARSLKINLPVTDPCLYVLRFAVLLEFGEKQKEVVSLATRIVQRMKMDWIDTGRRPTGLCGAALLLAARSYNFNRTVSDVVRVVHVSESVVRKRLEEFSNTPSSMLTIEQFSTVNLTECEDPPAFQRKVKEELEELRAKEEEIINNIKPELDAIEKKVEVALEKKRIENFRKSKWAKELSGNVIGLGADTEVATSLIGNEIIDLAISHSKDEYESPSKKEAPKEDNIYVQNWPTLEQMGVGRVNSNHTKSEGTDEESKREWENDGEDEEEDTLSDIDDDEIDKYILSPRERELKEKLWLKANSHHLEEMERRAKLKKEMEEKGEEEKGEKKKRKPPRKRAKIEADTATEAMQMVIQEKKLSKKINYDVLKEIGLLPPVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C887</accession>
    <name>A0A0N5C887_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-SGDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C887"/>
    <dbReference type="STRING" id="174720.A0A0N5C887"/>
    <dbReference type="WBParaSite" id="SPAL_0001414200.1">
        <property type="protein sequence ID" value="SPAL_0001414200.1"/>
        <property type="gene ID" value="SPAL_0001414200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001414200.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="22633" checksum="53EAF8446FA136F1" modified="2015-12-09" version="1">MAVLSKVSLNALPLLRKHLALVRPNEVQTSSIRFSHAHLFVRRPGELVINRIKDAIHFYFIGIGALPFFLIVAYNHIKYGNCELRDIPEGEVPHYWQYERTPMRQWWAKYFGISDMEHHERNLAYYERQQTLALWRRQQERVRHLEGERFDYKAWTYQPVSSKWIDYARWQAVRQNTQYEQHGRYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8F4</accession>
    <name>A0A0N5C8F4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8F4"/>
    <dbReference type="WBParaSite" id="SPAL_0001420250.1">
        <property type="protein sequence ID" value="SPAL_0001420250.1"/>
        <property type="gene ID" value="SPAL_0001420250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001420250.1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6846" checksum="DE18C13A88258B5C" modified="2015-12-09" version="1">MQFSQRPVLIVIVVGVSMSSVLIKIGELPWQLIVKIVCFFNLLLSHLMVHILSWKNNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9I0</accession>
    <name>A0A0N5C9I0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001456400.1">
        <property type="protein sequence ID" value="SPAL_0001456400.1"/>
        <property type="gene ID" value="SPAL_0001456400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001456400.1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3365" checksum="D836E03067F9DD9D" modified="2015-12-09" version="1">XCRQFSTSLDTIGILACISNVSRLKMNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAL4</accession>
    <name>A0A0N5CAL4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001493500.1">
        <property type="protein sequence ID" value="SPAL_0001493500.1"/>
        <property type="gene ID" value="SPAL_0001493500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001493500.1"/>
        </source>
    </evidence>
    <sequence length="9" mass="926" checksum="3C4C404415A2C728" modified="2015-12-09" version="1">XGLVSRING</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAU9</accession>
    <name>A0A0N5CAU9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypotheticial protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAU9"/>
    <dbReference type="WBParaSite" id="SPAL_0001501750.1">
        <property type="protein sequence ID" value="SPAL_0001501750.1"/>
        <property type="gene ID" value="SPAL_0001501750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895685" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001501750.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9932" checksum="540FDDC049D65950" modified="2015-12-09" version="1">MHVSKNSLQISIYLIFLFVLTVYCCDCGRCKHSTEIGCVRCCSAYVKKRSSELSNPYMWRVSPKFDSFNYHNRYYTDFYDDIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAZ0</accession>
    <name>A0A0N5CAZ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001505600.1">
        <property type="protein sequence ID" value="SPAL_0001505600.1"/>
        <property type="gene ID" value="SPAL_0001505600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895693" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001505600.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27007" checksum="B8A9C5CDAD51BDCF" modified="2015-12-09" version="1">MLIFPLFLAILFIGCQAYENKVTGGESASFNLRLNDVPYYSNNIGESGSKFNLVSGYVENKDLQKRQVRKSSAKSKSSKKVTSKKSKTASSQYIKMKYKLYNDINALRVEHAVPKLKVNVTLSKELQKYVEGLVKVDQTYKYQLLEPEDLYYIVKRGEKYDPIGFWSKDLKLFKPDDKIIFNLPLIKLIWKSSTHIGCGISGANNSRGRYRIIVYCRISPRRKIPEELSENILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB38</accession>
    <name>A0A0N5CB38_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB38"/>
    <dbReference type="STRING" id="174720.A0A0N5CB38"/>
    <dbReference type="WBParaSite" id="SPAL_0001510200.1">
        <property type="protein sequence ID" value="SPAL_0001510200.1"/>
        <property type="gene ID" value="SPAL_0001510200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001510200.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23537" checksum="EC9D36598ADBBE70" modified="2015-12-09" version="1">MNKTKNAEGNRDSMYYVMSLGVLFVGLSFAAIPLYRIFCEATSFAGTTQVAKDFEKIRNMEKVKDRLIKVQFNADVPSSMRWHFKPLQNEIYVHPGETALAFYTAKNPTDKPIIGISSYNLTPYQAAYYFNKIQCFCFEEQILNPGEEVDLPVFFYIDPDYANDPNLEYLDSILLSYTFFEAKKNLKLPDPFDPNNRPNVKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBF4</accession>
    <name>A0A0N5CBF4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBF4"/>
    <dbReference type="WBParaSite" id="SPAL_0001522000.2">
        <property type="protein sequence ID" value="SPAL_0001522000.2"/>
        <property type="gene ID" value="SPAL_0001522000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001522000.2"/>
        </source>
    </evidence>
    <sequence length="261" mass="29971" checksum="12042DC09ECFAD78" modified="2015-12-09" version="1">MSSLIRIKKRSRLPWNTNLSSNSSFTNQNTISKDTSSRSSNNNHLRTSDFSKLSKISAMTPPSYSVYENSEGEMINEKENVKWPERPLTGYHSLKEYKKRKAFIRKNIRDQEKYGKNKDKDHSSSTSALDLKQNEGSETSKKFQASCVTTGKCADMGFCNMPNINANEENSGKIDYINGSNVKQSYLFCGVKTPQEIKSFAKSRDIFYLFYDSKRTDDKIQFEIPLKMAYFDAEINDVSLTNTLLSLYILVCYQKCLQEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC09</accession>
    <name>A0A0N5CC09_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Venom peptide</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC09"/>
    <dbReference type="WBParaSite" id="SPAL_0001541800.1">
        <property type="protein sequence ID" value="SPAL_0001541800.1"/>
        <property type="gene ID" value="SPAL_0001541800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895722" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001541800.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13108" checksum="CE4E101F438A383F" modified="2015-12-09" version="1">MMVSSKKIFILFIVCALSSLIYAIPPSYVDPEELKLMINEWVKNVDNGLPPVRPTRSDLPNSPRKAYSLFHILTPAKFFDSLFTIGNVEMIMPKKPLSKNEEAQKYNKLTSTFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCB2</accession>
    <name>A0A0N5CCB2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein KRI1 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCB2"/>
    <dbReference type="WBParaSite" id="SPAL_0001552100.1">
        <property type="protein sequence ID" value="SPAL_0001552100.1"/>
        <property type="gene ID" value="SPAL_0001552100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001552100.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="31161" checksum="5A3330E126A10731" modified="2015-12-09" version="1">MNSNQNVHKGKVTALFELQVEMSKMKDEAKKVKKCPQYVSGGFSLKKRPHESKGSTRREKVDEEEEEIEEKRRKSYTAMEEKTKRYNEIKKNCIYDEELLVQPDDYDFPERNCSERNDEESGDLLSQDTLEENFNHEDLYRDYGPCNYTFSADEMLKKVQQDNLRQLSKETLGAREKAKELSYQRLKETYQRVIKAYERRNRPIISFEEYVAENTHYYTFKKDNDLEDHTLSDDSTEGNIERSKIRRRREWDIGKDLIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCQ7</accession>
    <name>A0A0N5CCQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCQ7"/>
    <dbReference type="STRING" id="174720.A0A0N5CCQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001565700.1">
        <property type="protein sequence ID" value="SPAL_0001565700.1"/>
        <property type="gene ID" value="SPAL_0001565700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001565700.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="51201" checksum="A8621988BDFF6971" modified="2015-12-09" version="1">MVIEDDNNKEVVICKNMKRNVSLNGDEFTEFTESLLQDCSCSFNHHTSTSKQETFINKEDKKVNDILSIITSDTDYKKLSIISNKFNTFNYNVPKRNLFLTEENQNFLNKLKYFNKYEKCSCIKNEDISSNDDTVNIGCSNGKMILWNFTKNIKMYFKKYFDDDILCQKVWKAPLNEYYMIKNLPSINKLRNILPKHSPECFLSMIKYFLIPISNNDSISGSYVLVNSNPKYTIIYSHSENSNLYHYTQIFPNIQSIANFLNVNFVTYDYSGYGISTGTPSIENLQETLKAIIKYVNTELGIKKDQIILWGSSLGGTLSADIMVDEKDLRGLILYDTPNTMLEYLCYKDKQFNYQKYQKYSKYRKDFNTLDAVSKINVPTLILRNQYNTNVSYVACFKIYRAIKNPVPCFTIYDNNDLFFSRETLWRVKEYLEYDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCT5</accession>
    <name>A0A0N5CCT5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCT5"/>
    <dbReference type="STRING" id="174720.A0A0N5CCT5"/>
    <dbReference type="WBParaSite" id="SPAL_0001568500.1">
        <property type="protein sequence ID" value="SPAL_0001568500.1"/>
        <property type="gene ID" value="SPAL_0001568500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001568500.1"/>
        </source>
    </evidence>
    <sequence length="1056" mass="119563" checksum="F9D447C906B02132" modified="2015-12-09" version="1">MSIPPEAFTSYMNSINAPTPRELENNHFFGNKKELLKSMEGTPGENITFTDSKKDVAKDSLCNNGVEENGWEHVSQKAKKPTNVIPRSSTTDSYTTKKIIRTNNALNHNWRDSSNGFIDREKKSFRCTEKFFTGKCGIMQSELDNNWRADNKKNVETNIYSSTHQQNSNKETSYAKEGGLMNNDRNWNKESLMNNEKKESSDSNIDDYSKSNSIHSQREVYKNTIRNEIRPINNHSEFDPLNSSLDNIFHPNDSRLHLDTLSGPLSNINNNVGFQNNVNAFDTLFQSLNINNGKLQYSEGFSNNLVFPENDTITPIQPNNVFDAFKDNLDVSNDYLSQIPMQLTGNEDFPQQNNTTTTNTTLGHSDFSPGHMGSYLDTVRINQAFNDTRKISSDIMSNIPKGMDINQHLVSSNLFTIPQVGVANNNPMQNLPEQLLQNFNVNQQQQIPPHSPHNGSNMFMNNAVNNYLGLLNLGITEKMIQSLFQVDAFSQLLQCAGWFTQRENLRWICVNDIGDVKGPFCAQDLVFKLINFHIPPLLKFHCEQLPFKGWLTLVELIRAADDRIPFISAYFPRTREEFIIIQKILKGVGEVPNSTKWLLFFQNEEKIMKQASHLFEAHIAQIVANLRTNPVLQKSNLQLTTEQFKAYVNTNFLTQQYQKDKIKGGNLHQQQQPNCEDVSRSQGFSHNANFNSDLQTANNQQDLSSKQLYNKQQCSNYFLGGGKVMNNIVNNSEIQQSVENHDTNQQHKHHQQSINRLSPRKKSLGDSKEHEVPSFHCGTWVPQNAKRKVSTKNSTHTNNISNGVHQHSEYHGRTNVQKPTLLSSSKNWESPNIKPDDDTPAGKVPIGLSLGEFLAPATGQIIERPSHHTPNTRSHNINNNNNWNNSLDNRPSTNIQTKQPEPIVNEPTIVSPTVPSRPVGAVWKNDNKSNGNSNGKGSSSSKNNNNTSNFGSEEATTELRQWLLERLKTFKSESDVMAFCQFITNVDNPADIEDYFSTNFGDSVDVRKIYRQYLEKRNEVRSRVIKAKSGQDDLSAPAQAIGFTSQPVKKNKKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD77</accession>
    <name>A0A0N5CD77_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD77"/>
    <dbReference type="STRING" id="174720.A0A0N5CD77"/>
    <dbReference type="WBParaSite" id="SPAL_0001582300.1">
        <property type="protein sequence ID" value="SPAL_0001582300.1"/>
        <property type="gene ID" value="SPAL_0001582300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="6">
        <location>
            <begin position="528"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001582300.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="100124" checksum="81468DB5B77EE816" modified="2015-12-09" version="1">MSNSMITNLVDLDTDTIDNIFEMDDFTNLTDFERTSFSLEVILRKWNIHVTKNTNLNKKNIEEIEWIENSEKFSFKNINLLIKYYHPKIGKINESTEKCDVPSYQNIIMNKFYTNVPEFVNKYGIIQWILICPESESNVISSKDDLTLLMSCLECCDIYCNIPFLIQFENTFKHLFYGFQKNKYSKYEYKSCYFKTISKFNIVDIFYDHFKYDTIKESDILHSSEFEYTYNLTKDKRSKYTFSYLFENFQFMDQLFEILKYDNDSKGIKNYIKGFKLLIQSDRQCNGEVNKCSNSKIDILSIDNNLSKWLFHTKFKNDGSNFLTNILKEYLTLFKDFEIFNTSIQNILLNVNERVSKKNFANSLFFSENVKIDSNNSLDLSLKTVTVEEIKGFQLNSKAIIKKLFSCAKHPPIKQNNSECCDNEYLLIKINLDKSKSAPSYSIIEFISLTISIILYKEKHGIIFSCILWNEFLNYLQNYFEISKHIPGIPKKSQPIFSHSTLQQDIEFLQCCINSKKKWSSFNDYQKYNGRSCKSKLTLYHYPNENIYIPILQDKIPQTEEMFHNEMENMIKTSSEERNVNQLIFLISDMSAFKAANPKCCFEDFIRWHSPNDWIFNNENNKYEFSPRMSSKDNTWRKAWDECIPLSVYKQKKHFNENEEWKKTIDKIKNITFGELISLILPSVFKGMIQLLFDNFEKFSSTVNKKFKKLSIDFLQSTYESNIEMYENILNDFSFIENYIERSFLLKSFLFNSGSDASYIEHILMDMADNNTIKIENNKRNEIKNLIETTIIDKDDNFVFEDQIESSKHDIFYYYNARIYMSYSKDGSRIYSKLPVLNNINKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDR1</accession>
    <name>A0A0N5CDR1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDR1"/>
    <dbReference type="STRING" id="174720.A0A0N5CDR1"/>
    <dbReference type="WBParaSite" id="SPAL_0001600400.1">
        <property type="protein sequence ID" value="SPAL_0001600400.1"/>
        <property type="gene ID" value="SPAL_0001600400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001600400.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51605" checksum="CA7E3476D3D61F42" modified="2015-12-09" version="1">MEYEDLDSINFTFNDLDIIENTFHKDGKIIINGILVADLDFQYIIYTWYVPFLFVILGIACIGNIIILSSSFFIQKPISIYLKLCLSLANSDLWAAILIAIGLYVNSYLPSVIGKPIPSLCFNLRLEVIRISGMFTSVLHLLALSVGQFLGIICPFKLKRYATSRRVNCTIICMYIFPVFIMSFIFYLFIDDEPLRPCTHSSYSQLPFRTLIFLLFTIPLIITFILYFIILYILLNKREGNLNRYGGSMVNRSKIQNKLNIVKITFTILTTFTFSWGICVLYFFLVCKKGCLIIYLVSIDFYTAFACNSFVNTMVVLKLALNPLIYAFRIDKIRDGIMKMFCTVGCSGIILHLCKLKKFYNNGSGIINIDSTREYQKNDNLLSIQEDNIIDEKFGIEMVEEIIPRGSENSNHLIGRKKRTPDGRRIIVHAEINDCCMINKDIKNISITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEZ9</accession>
    <name>A0A0N5CEZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001643700.1">
        <property type="protein sequence ID" value="SPAL_0001643700.1"/>
        <property type="gene ID" value="SPAL_0001643700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="53"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001643700.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38459" checksum="0638C64FC11A2EBB" modified="2015-12-09" version="1">MSNNTIFTDYCDGIEDDVFDNSVESITFISNVTIGLIHFMFTVFFITTQILMFISFYKMSKQKYHNMAFDIMRHHGVVSFIQQLCHLLTSVQTIFYINWAAIFSTIIGGILQSAYLCSILFILVLSLNRCDLMYNFKFFPSISRKKFYSIAAILCYVYFCLMTVFFLLPSNRMTFKFRYYEWDFVDDECLSSFGFVLEKLAVYSPLAVSFILYLMTFYKIVSLRNLKQKSTYFCPEDIKLIVHLLICYVLIIFMELCWNGHFFNIYKTQFGALVPHFVYILVSGANTTFTVFFVRNIRNSILGRCFSKSIIPASRIDNTQIKNIKVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFL1</accession>
    <name>A0A0N5CFL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFL1"/>
    <dbReference type="WBParaSite" id="SPAL_0001664700.1">
        <property type="protein sequence ID" value="SPAL_0001664700.1"/>
        <property type="gene ID" value="SPAL_0001664700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001664700.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16084" checksum="F9DE911FA54EF9ED" modified="2015-12-09" version="1">MSRSTNPNLNAQSDEDSDELGINKRSFPPFEWLFNNRFYNIYPFFNRLHTVDPDEQELINEIDDTYGFSSNSDTKEDDNNDEKYPIDEIQPESIINDDSQDNNGDSPNEELEEQDSTDERRDYDLRPRLTTINYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFV5</accession>
    <name>A0A0N5CFV5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFV5"/>
    <dbReference type="WBParaSite" id="SPAL_0001673700.1">
        <property type="protein sequence ID" value="SPAL_0001673700.1"/>
        <property type="gene ID" value="SPAL_0001673700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733488" description="Metalloendopeptidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="35"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001673700.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47991" checksum="794C240407013FD1" modified="2015-12-09" version="1">MDILKLISILLVLIVKVKKIICMDMYKENHIIKKRDILSDNFSSWIMPIKYQINDKDLINENVIKEAIKEIENNTCIRFNETNLSANNTQGIVFKLGKHCSSGVGRTFKNNTQVIQLTRDCSNKKGAVLHELGHALGLVHEHCRTDRDSYVIVHKENILREEKVNFEISNHSAYKNFSISYDYSSIMHYEQFDFTNGLLFWWWYPVLESRLHPAYNRMMGQRLKMTFNDYKKLNLAYCKCNQTEKKETKKKEVTKKKEKKKKGPENGIRCRNGGYIASSNSSKCICPFGYTGNFCNETIKSDKNCNGTTFNVTTKDIKTHWIAGSYKCFFSFVTEKRKKIQLGIYQSYAPYSKICTEDISHQIKYLKDKGTTGILLCSWRSDVINVTSEDNSALIYFNGNSNNAFMQFGFKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFZ9</accession>
    <name>A0A0N5CFZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001677700.1">
        <property type="protein sequence ID" value="SPAL_0001677700.1"/>
        <property type="gene ID" value="SPAL_0001677700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001677700.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8973" checksum="FCEF035BE0BFE78B" modified="2015-12-09" version="1">MFAFIFAWMQTMHNIVMDIAKYLVIYNTHVSIYERKFVQYLGMFIQILLMMYLAIYFVFALSPENFFSVTYVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG80</accession>
    <name>A0A0N5CG80_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG80"/>
    <dbReference type="STRING" id="174720.A0A0N5CG80"/>
    <dbReference type="WBParaSite" id="SPAL_0001685900.2">
        <property type="protein sequence ID" value="SPAL_0001685900.2"/>
        <property type="gene ID" value="SPAL_0001685900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001685900.2"/>
        </source>
    </evidence>
    <sequence length="373" mass="42748" checksum="C1E7FB04A5C2EBAB" modified="2015-12-09" version="1">MVLVCRSLICTWMSSINKKSHLIFSIPIKKWLEQKEKFFKNIIYLTSMDQKVSKIKTKKSSYFIQRVMTPFNMQCNTCNEYIYKGKKFNMKRETAHGEDYLGLKIFRFTFRCLNCLAEIKFKTDLENTDYTAESGATRLFEAYKLYQDQKKAEEEKEEAEKNDPMKMLEKRTQQSKAEMDALNELEELQETNRRNINLNLDDLIEQKASSIADDVKAQEKEDEELLDSLFGNKGESSSSTKIVEEVVGEITDSDESSDDEFKAPLPVVMGTNKPFLRLKKASSIADDVKAQEKGDEELLDCLFGNKGESSSSTKFVEEVVGEITDSDESSDDEFKAPLPVVMGTNKPFLIGQKRNAQEDKLSALKNFVKIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGR2</accession>
    <name>A0A0N5CGR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGR2"/>
    <dbReference type="STRING" id="174720.A0A0N5CGR2"/>
    <dbReference type="WBParaSite" id="SPAL_0001703700.1">
        <property type="protein sequence ID" value="SPAL_0001703700.1"/>
        <property type="gene ID" value="SPAL_0001703700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001703700.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30033" checksum="418904D2D04D0A18" modified="2015-12-09" version="1">MDYGSYFQQQDSNQNSGGNNSNNSNNSSVASSTIASFNLAFGNSNGTSASSGGMNPHMNPYTSIHQQASNQIYEQYNNAYSQLAAMGQARGIQNMSNHGTTNSSSTALSVSNGSGYNKAHDSLQAFFNTGLPYKLYPNSNALLPSTHTENTLRVASNATNSSLIPSFANGASLVGSLCTSTSSFNPTERRKQRRIRTTFTSSQLRELERAFAETHYPDIYTREEIAMRTDLTEARVQVWFQNRRAKYRKCEKMRIKPKDENDNCRAIEESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGW9</accession>
    <name>A0A0N5CGW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADAM_spacer1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGW9"/>
    <dbReference type="WBParaSite" id="SPAL_0001709400.1">
        <property type="protein sequence ID" value="SPAL_0001709400.1"/>
        <property type="gene ID" value="SPAL_0001709400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001709400.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44538" checksum="45E60D2DBF081859" modified="2015-12-09" version="1">MITLKSSALILIIVCGIGNIFIEGVGGRGRRNKDNGDDLYILLDEANVFRCRGVNNLITINESDINILNDKGNRVYYIKAPGDYSFNFGKINVLDNLGHLTGELGITLQVPLLDGPAGIRFDVPYTMVPETGLLNQECDEHSGIVERDGRQYCRYCELCSISSKVESALKNNKLLPGLAKGEEKAFGPKCGKIGSNTYDFRRTLHVPGRKELEKKIKEKIQGVDAEVRKRLNKGRGRFQVFLNLISADQPPISQKAWFDGSDQCRGCGPGNRGKGNPALSFLYCNTEDCKSAWAQQCLHNSAKIAACITVEFNYRITTKYSEVLQFLRENNYPNQDTATPQPTTEPPHEEPAPDASQSSLENLSERCVAKMATRLTHLRRYCTIFWNEKLCCQHCEGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGY5</accession>
    <name>A0A0N5CGY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGY5"/>
    <dbReference type="STRING" id="174720.A0A0N5CGY5"/>
    <dbReference type="WBParaSite" id="SPAL_0001711000.1">
        <property type="protein sequence ID" value="SPAL_0001711000.1"/>
        <property type="gene ID" value="SPAL_0001711000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001711000.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39462" checksum="2497A013A0FFC98A" modified="2015-12-09" version="1">MSNNTTIDSLECFTPYEEQDRIIIGIIALPLIFVGLIANFISLRIFLNKLMRQQTLNWYLMIISMSDSGILIGAFFVLTFPRLSESLLFSNGVKVCYYATPFMFGVMTISQTVSVWMNTVMSLHRFIGVCLPFRAGTILTAENVKKVICGVLVCATIFNISRFFEVIVDGVCYAEVLKGYIPHLTATALRLNGIYRMIFYEWSYTLFMFVIPFTILIVVNTMVIIAVHRSRKIHAKLNMYGDDVRRQELAKEISTSIMLVAIVLAFLFCNTLALIVNILEKIQWDELVIKVVPFSNLLVIINSITNLCIYCLFSDKYRQLFWFYIRCMPCRGKKGQFEAVFNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI12</accession>
    <name>A0A0N5CI12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI12"/>
    <dbReference type="STRING" id="174720.A0A0N5CI12"/>
    <dbReference type="WBParaSite" id="SPAL_0001747400.1">
        <property type="protein sequence ID" value="SPAL_0001747400.1"/>
        <property type="gene ID" value="SPAL_0001747400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF93">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001747400.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26938" checksum="5A186F694E084098" modified="2015-12-09" version="1">MPMIPPVVNLDKMQGKGMGETVAKSYYSNANPISIYCTNLTVKQSQLEKEIMRETLKSHDQSIMLGAPEVLQVGKNFIRLIHAKKCLDIGTFTGASAVAWASALPEDGKVYSFDISHEALDSIGKPLINEVEGVSKKISFIKGQALDFLDQFIANGESGTWDFAFIDADKSNYPNYYDRLMKLLRPGGVILVDNALWSGRVANSDCCDEATNAIRELNTIISEDDRCDNMLLNVGDGLHIVFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIJ2</accession>
    <name>A0A0N5CIJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001764600.1">
        <property type="protein sequence ID" value="SPAL_0001764600.1"/>
        <property type="gene ID" value="SPAL_0001764600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF11">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001764600.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38211" checksum="5E7970EE324F9001" modified="2015-12-09" version="1">MVFNLTYDDDVTIPQINEDNNNVYIGLSYIILSCSFMFLQIMTFVAFYRNREILMKNMPYRIMLQLGIADLIQQLCHCISGFYAVFYFFPSDVLSFAVGSLLQCAYMTSASFILLLSLNRFDVFYDISIIPTFDKKRAFFIGIVICYIWGIALFIFYLFPSNRLEFSSINYGWNYTGNKTLGYQIENKSVLTMLVISFICYLFIIGKIMYMRGLSSSGIIITFSDMKLLVQAIINFITITLLEICWYQLSGIITDAELNLLAINYLFIFVSGANTLLNFFFIKEVRREVKTILICYTNGKQNITRTVVRRIPFRDRDKNMSTKTKILTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1R4</accession>
    <name>A0A0N5B1R4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1R4"/>
    <dbReference type="STRING" id="174720.A0A0N5B1R4"/>
    <dbReference type="WBParaSite" id="SPAL_0000001800.1">
        <property type="protein sequence ID" value="SPAL_0000001800.1"/>
        <property type="gene ID" value="SPAL_0000001800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000001800.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52534" checksum="30C87471753DC28C" modified="2015-12-09" version="1">MDFGAKLIALAMSKGYNMEVPPIESIKTENTDVQQRGMFLEDICDATGEIDLNKLLKQIKACNSQDSPTLNEHMPLIFTLAYKYGCLKKRMKGGVRCFNKEKIELPVLQQYDEKNPREFLDKFRMRYGSLETTSQHQLFKEYLSGSALIAYKALKIEDYNSFKEFAEAWIEHYKPNFSNKRREIILEQLLINNSRKADSPLQYVNCIQGWINELSELRHLSDSEIAKYWLAAAKGLQRYDEIFDYYFSPNRENSLLKAKVLAALKKETQRDFNNKKENTGPSTIEKDFRKEVNMIECDKPSDNSNADNKISYVCRLVLNGKENLVPCNIQGKESNCLLDSGAEVSLITISKVKQMDPLPIIKKNPRIIVRDVQNQPLHLLGSTELLVEDILVPISEPNINAEWKPCYVLQKFNNSVYVIMEPGRCITRKTSRFVKLSPQALSDKLVAEAKSKLEGCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1W7</accession>
    <name>A0A0N5B1W7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 4c3</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1W7"/>
    <dbReference type="STRING" id="174720.A0A0N5B1W7"/>
    <dbReference type="WBParaSite" id="SPAL_0000006800.1">
        <property type="protein sequence ID" value="SPAL_0000006800.1"/>
        <property type="gene ID" value="SPAL_0000006800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF194">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000006800.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="57592" checksum="32544D414DD3DBB7" modified="2015-12-09" version="1">MNPIIIILAIFFLVGILLFYHIKSRRKFGDFPSPRSYPIIGHAALLRPNVTERLDQLMGTCLLYSEYPRMTLLWLGPVPVVMLYCAEAIEAVFTGSKHLQKGKLYKFLEQWLGLGLLTTPPSTWKGRRRQLTPTFHYDILKNFVYVFNYQAEIFVKNLKERFKDSKECVVDIGHLLSLCTLDIICETSMGQSVNAQKYSDSEYVKAVHEINDIIQKRQLNPLMWNNTIFKLTKEGKAHDKDIKILHDFRSNVIAKRIKQIELDGGLNVNQKCNFLDLLLEMRSNGELTLEQIECEVDTFMFEGHDTTATALMWFLQIIGCNPEVQQRIRDELYSVLGYEFTEVSFDQLGQLKYLECCIKEALRIFPSVPMFLRKLDHDENVFGKYHIPAGTEIVINAYLTHRDPKYWPEPEKFRPERFMPPESNHRHPYSFIPFSVGSRNCIGQRFALLEEKSILAHVLTNFKVTSMKRMDEIRCKSELILRPLEPILIKLEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2G1</accession>
    <name>A0A0N5B2G1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2G1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2G1"/>
    <dbReference type="WBParaSite" id="SPAL_0000026800.1">
        <property type="protein sequence ID" value="SPAL_0000026800.1"/>
        <property type="gene ID" value="SPAL_0000026800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000008">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000007">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="76"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000026800.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="41108" checksum="24B7E6481657996D" modified="2015-12-09" version="1">MSGVEGDDKEILALPLTDKHGFIRKDEEITEENQPPKGLSADVVLRRERKWLEMIDHWNSYMAGKFDIIKRRCRKGIPDSLRGRVWKHLCGAYFHMHIGKNKNVFDIVSQQSADPKYVDEIVKDLDRQFPEHELFSRQTPYGSRGKEDLFILLKSYTVLHPDDGYCQAQAPIAAVLLMYMPLKDAFYCFVQICHKYLPGYFTRDMEQIKIDGEVLKYIMKAKCPKIHFHMKKHLVEPSMYLIQWFMCVFCRTLPWPSVLRIWDMFFCEGIKVLFKVALVIISETFGNKKALDECPDQGSILMKLKELPKELLSEDVLIKKVLDTNLDEYDLERAHYRIIKNRKLRSDTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2K4</accession>
    <name>A0A0N5B2K4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">5'-nucleotidase</fullName>
            <ecNumber evidence="3 9">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2K4"/>
    <dbReference type="STRING" id="174720.A0A0N5B2K4"/>
    <dbReference type="WBParaSite" id="SPAL_0000031100.1">
        <property type="protein sequence ID" value="SPAL_0000031100.1"/>
        <property type="gene ID" value="SPAL_0000031100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000031100.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34593" checksum="581ACFE3487AF537" modified="2015-12-09" version="1">MDFLINNRKVFMKSKEYVSRIINALSEGGPKNLTVISDFDYTISSYYDENGNQNLTTHQLFRKGTEVSNPDLGPKLKKHFDKYFPLEYSNELTIAEKIPLMEEWWRLSHDAIAEERLHRDFIVDVVKNSNLKLRDCFKKFNRQLHRMNVPLVVFSAGIGDVIDMYFREKVKLTEDNIYIVSNSMIFDDDNICTGFIEPLIHTFSKNSSVIKENSPLFDVVKDRKNVLLIGDSFGDTTMEINSKRKGNTLKIGFLNFNKSNLLQKYINCYDIVCVDDQTMEVPNYITKIIESGVYVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B411</accession>
    <name>A0A0N5B411_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B411"/>
    <dbReference type="STRING" id="174720.A0A0N5B411"/>
    <dbReference type="WBParaSite" id="SPAL_0000081400.1">
        <property type="protein sequence ID" value="SPAL_0000081400.1"/>
        <property type="gene ID" value="SPAL_0000081400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000081400.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20317" checksum="00C0DF2B0CEA3868" modified="2015-12-09" version="1">MLSKLITKESILKNYLQYYIKRCASANLQAGRSKAAKQLVMPASEQGFFNYERYISRDKNCPNPQVQGDTPYRLMFRRLGHAYEIYPLLFLCSAWFVCFIVITWWSFQKMEVWVDRSQKTAPWSWDKIRNNYWKSKKIFFDPEGIMEKRLEIMEVLQDEMLEAAKKKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4E0</accession>
    <name>A0A0N5B4E0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4E0"/>
    <dbReference type="WBParaSite" id="SPAL_0000094200.1">
        <property type="protein sequence ID" value="SPAL_0000094200.1"/>
        <property type="gene ID" value="SPAL_0000094200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000094200.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36627" checksum="E11C7884BAA4E70B" modified="2015-12-09" version="1">MATFLTDIILAAFSLIMSGACLHFANALYNLKKYHVNFRTLIVSLLIFNSTYYFLVFVFEMIFIITGDNNYFDVMILVDFYILYGGIYYLQLFIFIERIIAVSCISRYELSSSEPPYIALGFMILSFGVTALHKILIRNVFEAYDIMSFEIIILSVLAFLVYHYLHKKEIDKRENDFLQYLTNNLSYKFQYYENQKTYSLTKYLLGIFLVFESLRLISRAVLDSFTRCPNFHTIMYLTVFVLSIMKIVAHLYVFVLNEPKMRESFINLFDSRCRGYSENDSNVALYVNSNSLESADRERIYFYGYRRQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4G2</accession>
    <name>A0A0N5B4G2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4G2"/>
    <dbReference type="STRING" id="174720.A0A0N5B4G2"/>
    <dbReference type="WBParaSite" id="SPAL_0000096400.1">
        <property type="protein sequence ID" value="SPAL_0000096400.1"/>
        <property type="gene ID" value="SPAL_0000096400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000096400.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20841" checksum="E948A9765A768BD6" modified="2015-12-09" version="1">MLYNYIANCKFVSVCGSAVLISERVHRSKPLPFLKGLNKNAVIEYHSLGGYNLTKAQFKQNRDSWAAKQNPTVKSIYDEYQANVTKSMAELKADIIKATADLTADAKAVFDKIEAVRENQNISYVEEHKQIKVILFGTTDAIRNEIRKKVLPRLKGGRGRRMRHKLRLILASQPTKLAVYLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4L1</accession>
    <name>A0A0N5B4L1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4L1"/>
    <dbReference type="WBParaSite" id="SPAL_0000101200.1">
        <property type="protein sequence ID" value="SPAL_0000101200.1"/>
        <property type="gene ID" value="SPAL_0000101200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893885" evidence="2">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000101200.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21395" checksum="32CF0BDA554661C8" modified="2015-12-09" version="1">MNFLKYLIILGLFTIQYSIQGSSSEEDSSSVGENNEISEESPELLQEASDTPDLDVSSDSTDSTMNQENNKTDSKNKSRAKKFFSKLGKGAKKVMKSETTKKIGKSLAMGGMKLVQSLIENSKKQSSSSESSEEKENKHKKDKKTKENESEKKKSKDKEEKPGFFGKLKEKVTDGAKKGLAKQMSKQMFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4N4</accession>
    <name>A0A0N5B4N4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 18"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4N4"/>
    <dbReference type="STRING" id="174720.A0A0N5B4N4"/>
    <dbReference type="WBParaSite" id="SPAL_0000103500.1">
        <property type="protein sequence ID" value="SPAL_0000103500.1"/>
        <property type="gene ID" value="SPAL_0000103500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000029">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 18" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000103500.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31087" checksum="53E5E13FA7099971" modified="2015-12-09" version="1">MICSASNIVKAASALNFNAIRCCSKGANIKTFEIYRYNPDQPGSKPEVKKYNVDLNKCGPMVLDALIKIKNEQDSSLTFRRSCREGICGSCAMNIGGANTLACICNIDKDTSKSTKIYPLPHMYVVKDLVPDMNLFYAQYSSIQPWIQRNTPMNLGDKQLYQSVDEREKLDGLYECILCACCSTSCPSYWWNSDKYLGPAVLMQAYRWIIDSRDEKHEERLNRMRDAFSAFKCHTILNCTKTCPKHLNPAKAIGEIKRLLTGVGKKPTPHPAPADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4P8</accession>
    <name>A0A0N5B4P8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4P8"/>
    <dbReference type="STRING" id="174720.A0A0N5B4P8"/>
    <dbReference type="WBParaSite" id="SPAL_0000104900.1">
        <property type="protein sequence ID" value="SPAL_0000104900.1"/>
        <property type="gene ID" value="SPAL_0000104900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="646"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="648"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000104900.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="81684" checksum="2550A7C5E70B4D9B" modified="2015-12-09" version="1">MIIIRGEIKPSMEGTFLNVIIEPLLNIRKTLNLSLCERHIKRTIIVSPDVVIENICGEVLTIVGLGHLTNTSEASVFVPNSKFSPDLFCLSRPGITVGHLKGIFGDQLYIKISAKGEPTDFTEESMNKNLFINLIRVFIKEVPFVESHIVDPFYRNLIEKIKTPSIAPRLPGVTLQSLVGLKQLIDSILCDNIFTPVGILNEQRLFTNTANALIDNIARPTSNNNNNVQNVLESTPSSSGIGVSIANRNSELKPQEQSSPGYIGIPIRKPSETKEPEIMPHPTPSRNELNSMESEEPQNESTKLKEEVNTSNNTEEDDNKYQTPNENDILERWYKRNPQIPSFYQLSVLAQHLNTIYERPPESQLTGEYLFWWYTNPMEYLTVNLIIEPVIGNQHVSSPQASYGNIKMTVTIDPTVLIKDICQVVMNKIGLGHLIQYSQAFIKYPRVDYFVSAYCFTNQNATVGNLEEWHKEYVTVKICARGNVEDFCGFEGRNTLYRNLLQLLLKKYPFIRNQENDPFIREAIDRINDSSLSTLQHSYLYCVNEVIVKELVNLPYTTSRYNYPVNETSQEYEQETIKQMTPERSLPQYAHPTEMTPPKSVQSIPTPYRSSSNQIQSPSDEVGSNPPSDGERPSASTIKPPQGNTSPTRKRIIFNKTVEIPILEDWYKKMNVPSEHQLDVIAEILNEASGRSEDRKVTAKNVCNWFTHKRSKDKRGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4T2</accession>
    <name>A0A0N5B4T2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4T2"/>
    <dbReference type="WBParaSite" id="SPAL_0000108100.1">
        <property type="protein sequence ID" value="SPAL_0000108100.1"/>
        <property type="gene ID" value="SPAL_0000108100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893722" evidence="3">
        <location>
            <begin position="24"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000108100.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65029" checksum="598A61CDD54E5991" modified="2015-12-09" version="1">MKIYSTSLIFSFFTIYLIAYNNGQENQELVDFAQKVFVNVNNLTNILQEGKQTDIGTLRKSISSILGGGLLGQIAENPIRLADHFGIDLDNFGFNRTILEQTIGIETDKSKENYDTSKGDQIFNLKNIKNAPAEVTTQPPTTTTTIPPTTIEKITNTFDSVLLDDFGNVLPMTSFVQENKNFAPPSSSLNIQVPSYSLPQQNTMHNQQKLHQQPQLNSSPTVTAKIDEIQEIKEQLKKLEQLLILKEFTQKYPDLAEKIVASNSPKTQQSQPQPIQQQYIPPNHYQNIPSQVNQQPQPTQTSSFVELSKPSPIVRANYVPVVYKVQDVPLQHPKVIEKPKKSSQRSSRLSLLQNQPRYPYKKINQKEVINYNNDENIVSKQSQSSLQSTSDVKCECLDVEMDQLRGSWTKAMSSGKMITKFKKIVGKMFGMEGKMELTCSAFTIIPSDNDEETAKIQWTFRTPNSKRPFKINGILKLINEKRTALVTFTDFNGFVTEIPLCILKNSDPSENGKMNNYIVVVENNLCSEPLLMISNPQNFFDQVDHELIKYLKHMIQSGQFSTMDVVSTGETCSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Y0</accession>
    <name>A0A0N5B4Y0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Y0"/>
    <dbReference type="WBParaSite" id="SPAL_0000112925.1">
        <property type="protein sequence ID" value="SPAL_0000112925.1"/>
        <property type="gene ID" value="SPAL_0000112925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000112925.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17536" checksum="3CA9C61088ABB3ED" modified="2015-12-09" version="1">MIKRIKEELRLLIDEKENIFDKESKDNILKKHDEMEFTEKFDFNDISGVLLMETCYKDIGISESENIKEVLKNIESLSKLNHTFRSCGYNIFKVNEYIDDFVHSNAFYYSILNLFSISSNSLNHEKFLIIIPNKVDGDSFNMYNLFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B661</accession>
    <name>A0A0N5B661_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B661"/>
    <dbReference type="STRING" id="174720.A0A0N5B661"/>
    <dbReference type="WBParaSite" id="SPAL_0000155000.1">
        <property type="protein sequence ID" value="SPAL_0000155000.1"/>
        <property type="gene ID" value="SPAL_0000155000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF60">
        <property type="entry name" value="CUTICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893945" evidence="2">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000155000.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17249" checksum="1DF13714BBEF1350" modified="2015-12-09" version="1">MKILLILLFIIYFIYECFCKPPTTISKIRNSVTNCKITVSKDTLNGETISSAMLESVLFFKIACLPIRGYCLHISNCYISSNDTTSYKVIDTNGCSIEKDLFDNVVYLTDYAGYIKNPIPVKFRNSNDSIILSCDTKMKLKDKFKSCQIVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6X6</accession>
    <name>A0A0N5B6X6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6X6"/>
    <dbReference type="STRING" id="174720.A0A0N5B6X6"/>
    <dbReference type="WBParaSite" id="SPAL_0000181300.1">
        <property type="protein sequence ID" value="SPAL_0000181300.1"/>
        <property type="gene ID" value="SPAL_0000181300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000181300.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24447" checksum="437537D0EFE5CDC9" modified="2015-12-09" version="1">MSSSYKRKIQISVTLRNESETAHRSSVNSLQYDKNTGRLFSAGSDSIIRIWNTSKPDSSINETTSKRYIQSMEHHCDWVNDIVLCCNGQNLISASSDTTIKVWNAKQGFCMSTLRTHQDYVKALAYAKDVELVASAGFDQAIYLWDVGTLTKLTATNNTVTTSSLNGNKNSIYSLAMSCAGFDQAIYLWDVGTLTKLTATNNTVTTSSLNGNKNSIYSLAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8N2</accession>
    <name>A0A0N5B8N2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B8N2"/>
    <dbReference type="WBParaSite" id="SPAL_0000240500.1">
        <property type="protein sequence ID" value="SPAL_0000240500.1"/>
        <property type="gene ID" value="SPAL_0000240500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="7">
        <location>
            <begin position="269"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="812"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000240500.1"/>
        </source>
    </evidence>
    <sequence length="1366" mass="151090" checksum="F711B86C54B2B412" modified="2015-12-09" version="1">MDKYKKKFASAFDGLRNHHTKVDIEITEKITSNNIGLTKIIRHGFPDKARCLAYDPVQKLIAIGSGNGSLRLLGDAGVDYHLCHPSGTEVTHIKFLINEGGLITVTKDDMIHLWNYRQKQADIVHSLQMRQEKITCIELPVSSKWLYIGTERGNVYVLCVANFKLSSYVINWNKAIDLSCRTHPGPVKHLSISPLDPTKLLIGFDNGYVVLWNLLNKEVERYKNNGQIKNISWHHDGKQFMCGCIDGSLVIWNVKKSSEPCQVIYPREQKCRPITHLFWFQGSSNDMVIFAGGMGLDDGATPAITVMKPKGSLAVLELDHTIVDICPILNSPYTNFPQLPHALAILMKEELVILDLSISGFPIFENPHPTDISESPVVYMKYYSDCPVDMIGALTLLGCKQRTANPRVSTKTWPITGGEEREVATSNQELLLTGHEDGSIKFWQSSGDHLQLMYKLKTGRHFEKTEPTIPTSQSPEYIKNPHSITFIAMCLESRLLAVAGNAGQVTLFRLNKNESANDIAVINILGSYSVDSPFNQSTSNVGDCGGLRNQNSVISSRTSSMTSEGSQTSEQHLLKVRGGAIRRAAGFQPELVCLITSTAHSLINNKKLIGSISLNSSFGLMAIGTVNDLCLIDIVQCTLVVCLSISELYSFENTSNTQLCLNVDSPQDPLSMSQYCSELTNNFGSNDLTSGENVCNKKDIVNDKGQYLSEQTPSIVNILRRRTSEMAHSAKKKIEKKFSQHHSTINNKYNNDKIPPNRPDVLSTSFNSNVKDNSLRPVPFLSVDLVDTPSPCSLPSPVSDHTSYSMSNVSFSLQSSQENPDNRPKSENNMRGKLTRSHKLPSFENAELVKQFSDEHEHLSVSSSNLKAQSPFGTASNIVRRLTGKNFFGKSKLVITKNEKSEDITPNSSYHDLTDNLLYNNIHCDLRQKSYDKRPILARAQSMAAGAVASLTGNNPDLNFGENGNNRDSSYSNLTTQDSPSISSSLEKLSLYETITFVEFISTVTTKNSTKVIPTLYIGTSSGVCLAYSLNIPTERITSSVSFSNILCAQKLKGEMLYCCFMDDTFRLLSGPSESYKESNSDSPKTTQNKIITKNPLLPTISNSNDSNTVMDEINQITVIVSEFEARVIALPNCLTIFSYKSDRSFVKVEASHTNGYPILIILNEAGEIVVLSLPSLKFLYKSQLFSKSVDLDDPMVTKIAFSDYGLGAYMVTPSEIQKFTISRELAAQISECSGEVFIPKDMPEQPKPSLLQGVSTLFGGGVTKDINSLEAIFNDKDKNGQGLVTMKSIARTIQSPAMTNMEHAQGRGISAGQAAQMALQNLNERTDKLNAVVDTTENLKNNAQSLATRSGKLVEKYEKKKWYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Q9</accession>
    <name>A0A0N5B8Q9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8Q9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8Q9"/>
    <dbReference type="WBParaSite" id="SPAL_0000243200.1">
        <property type="protein sequence ID" value="SPAL_0000243200.1"/>
        <property type="gene ID" value="SPAL_0000243200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000243200.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36949" checksum="9BBDD4A9D42CF70B" modified="2015-12-09" version="1">MASESLSVSVMKQEPSPGIKIEDEVYDHEMTLEEDSHSDFDNKSPTLNCSFNSHVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKNLGEVEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKNVSTNSSPTLINHQPNMTAQSLPRMGSNQPSVLGNINSISPFGGFTNPQLPLNPLLTTQLLNHLSDLSKLSNGGNHPHHPQQQQPQPPPHHLQQNQISAAAAALSFEAMQRSILQHMALSQFHQVPQIPQMKPSQVATNPSKTSTTSPTSDMENMVSDGNSSSPMNSNNNNNTASLLLNSIGVSPAAFMHSLTTAPHNLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8T1</accession>
    <name>A0A0N5B8T1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8T1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8T1"/>
    <dbReference type="WBParaSite" id="SPAL_0000245400.1">
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        <property type="gene ID" value="SPAL_0000245400"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894155" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000245400.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23285" checksum="6606F26B38B266C2" modified="2015-12-09" version="1">MSIAKKILILFFILHFNYCNGKPEKCSLPKKVGVTCDNSSGGKRYYFDKNSGVCQFFIYKGCQGNENNFDTLDECKSICGEGKEDQTWVLADKCGSNYLIPNGEYISCRSGRSTCPENHTCQPNGVCCPTKAYVCTLEDDTGNFAVGVPDKPRFAWSDAINSCVRFSYYGANGNYNNFPNFQSCIKYCKNYKEESSLEALEVEIRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B992</accession>
    <name>A0A0N5B992_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4794 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B992"/>
    <dbReference type="WBParaSite" id="SPAL_0000260700.1">
        <property type="protein sequence ID" value="SPAL_0000260700.1"/>
        <property type="gene ID" value="SPAL_0000260700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893943" evidence="2">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000260700.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30762" checksum="D493642CFC573488" modified="2015-12-09" version="1">MKFLLIGLLAVLSISNISGYKKPNVHNEVEDIDLLKPLNDATPDDYDSFNVKPLENRHHSSLKSVQFATIKSTMATRPTLRTTTPIPSTIRTKVVGEGQIPVRAGGNGYIMPYIQSLPRAGKFYEHYPYNKLPRAYQLRPDLYYVYPREFQNVVYRYPYEKLPYSLLTWYQQQQVANNAYNQYANQYYGAYYNQQYQGHGRGGYVPEDVSVTEKTEEPKFNDNFEREDFEKLAAEAAEEKNLEKTATTAKTTESFFDEDIATRETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Y1</accession>
    <name>A0A0N5B9Y1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division protein kinase 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Y1"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0000285100.2">
        <property type="protein sequence ID" value="SPAL_0000285100.2"/>
        <property type="gene ID" value="SPAL_0000285100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-dependent kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000285100.2"/>
        </source>
    </evidence>
    <sequence length="313" mass="35415" checksum="72F0E1444E9BC6B8" modified="2015-12-09" version="1">MSHYSDLQNIGQGKFVFLTFIYVFIGTYGTVYKAIDKRNNSTVALKVIKLDDEDEGVPSSALREICLLKQLKHPNIVTLLDIMHAEKKLTLVFECCEQDLKKYFDQCEGKISQTQTRHLMQQLLRGLSYCHSHNVLHRDLKPQNLLLKNNGLHLKLADFGLARAFGIPVRCFSAEVVTLWYRPPDVLFGAKLYDTSIDLWSAACIFAEIANGGRPLFPGADVEDQLKRIFRLLGTPTEETWPGVTNLPDYIQLPIFLPGMPLSQVVPKLNILGIDLLKNILIPNPIYRMDAERCLLHPYFSSPDDVKSPTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAA0</accession>
    <name>A0A0N5BAA0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAA0"/>
    <dbReference type="STRING" id="174720.A0A0N5BAA0"/>
    <dbReference type="WBParaSite" id="SPAL_0000297000.1">
        <property type="protein sequence ID" value="SPAL_0000297000.1"/>
        <property type="gene ID" value="SPAL_0000297000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="142"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="320"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000297000.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42998" checksum="82CCD36D6BE628D0" modified="2015-12-09" version="1">MDALKERRSTRSTKRPQMGDDNEDFFALPASEQSSRTADVFNNSVEASEEVASEVRQEERKMGFRLLKDLTTIDKDITASDIEKLKERGFLTYESVMYATKKELNSIDGLSERKIEKIIQLVSGHVNMGFTSAAEIYIKRKDIIMIGTGSEKVNELLKGGIETGSITEIFGEARSGKSQFCHNLAVTCQLPVSRGGAEGRCLWIDTEGTFRPERISQIAQRYNLEPEAVLDNIACARAFNSDHQRDILVEAAALMAAYRHSLIIVDSVMALYRTDFQGRGELADRQAHLGRFLRHLLRLADEFGVAVVMTNQVMANVDGSAMYGGDTRKPTGGNIMAHASTTRLYFKKGKGEQRICKVYDSPWLPEHEARFAISNEGIIDVPEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB35</accession>
    <name>A0A0N5BB35_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin--tyrosine ligase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB35"/>
    <dbReference type="STRING" id="174720.A0A0N5BB35"/>
    <dbReference type="WBParaSite" id="SPAL_0000324700.1">
        <property type="protein sequence ID" value="SPAL_0000324700.1"/>
        <property type="gene ID" value="SPAL_0000324700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF39">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000324700.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="47348" checksum="589FE9B4207FC165" modified="2015-12-09" version="1">MKKFRDGKIYWKCALSNTIYEVLVNRKNFYPVQNDSWNFYWVNREWMNTNFDKHKFKDNQLVCHFRNDYELTRKDNLIKNLKKARKIPELEKCLNFVPQSYVLPSEWHIFVEEFKKYDSGTIWIMKPVAGAQGKGIFLFKKLKEITEWKKRDYASDSEALPYVTQMYIKHPYLIGGKKFDIRLYVLVRTFRPLTVWVHREGFARFSHSKYDLSSHENAYVHLTNVAIAKTAGDFDPERGLKWSLKKLFRYLMALHGIDEVTKIKNDIGNIIITSLRSVQQLMIQDKHCFELYGYDILLDENLKAWLLEVNASPSLTPSSQDDFEMKYRILNHMLDVLDMEKKLQGNETEINGFDLLIKNNEVVYKSSYVPRDSEINPFVPGINLKLGHYVKPMETPLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB38</accession>
    <name>A0A0N5BB38_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB38"/>
    <dbReference type="WBParaSite" id="SPAL_0000325000.1">
        <property type="protein sequence ID" value="SPAL_0000325000.1"/>
        <property type="gene ID" value="SPAL_0000325000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000325000.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11152" checksum="8B408B3E7EE68DBF" modified="2015-12-09" version="1">MISKLSNYIGRGISETKLIVTLSLPLRNGNFPLISYFQSFQKLKMNFNIYFFAVIAVLSLSVFGAKSCDNNLQKKGAKTTFKETRASHPGGNTNQGNRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB61</accession>
    <name>A0A0N5BB61_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB61"/>
    <dbReference type="WBParaSite" id="SPAL_0000327100.1">
        <property type="protein sequence ID" value="SPAL_0000327100.1"/>
        <property type="gene ID" value="SPAL_0000327100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000327100.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21984" checksum="65E2DB90274A5087" modified="2015-12-09" version="1">MLYFQYIIFILFFLCPKGYKILLFNPKIGHSHVNFMSQFTKILVNAGYEVTVLSSNITDTLKYPYHLSEVTKGSEHVRNLWKSAEGISGNRNLFKKFMKAKRDQGISVINDKKLEIFIRKQNFDIAIAESMYTFMFGLFKNWKIETTIVTTSTVMFDPFYPMFGIRFPVFYVPSGISGYSDKMSYKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDG0</accession>
    <name>A0A0N5BDG0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF362 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDG0"/>
    <dbReference type="WBParaSite" id="SPAL_0000404600.1">
        <property type="protein sequence ID" value="SPAL_0000404600.1"/>
        <property type="gene ID" value="SPAL_0000404600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000404600.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8135" checksum="71A22F7787254D77" modified="2015-12-09" version="1">MEERFGESVVAVDDKIDVFSRHPLVPNDSRLVTLPVLNIGLLSSNVLLADVLKVPLAIDGNLLSDCLYTDPDVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE47</accession>
    <name>A0A0N5BE47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BE47"/>
    <dbReference type="WBParaSite" id="SPAL_0000427400.1">
        <property type="protein sequence ID" value="SPAL_0000427400.1"/>
        <property type="gene ID" value="SPAL_0000427400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000427400.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22050" checksum="2B41E0B12632B634" modified="2015-12-09" version="1">XIEDIRKVGKEINSLIDLIEKDSSMEERFRKKLHKLADLVPAQIRGTLKYGGCCDSFELAMVVAEDLWKINIEAKKDSSFYGNRDNRRSKSKSKGFSENCFKCGEKGHRAKECKKKPNPQVSSLNISTLKKLPQVPVIPIKLDETPAMAMLDTGASISVISKELGDKLNIPVEKKKISVKTMGSDKCFVYKTRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEK1</accession>
    <name>A0A0N5BEK1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEK1"/>
    <dbReference type="STRING" id="174720.A0A0N5BEK1"/>
    <dbReference type="WBParaSite" id="SPAL_0000442700.1">
        <property type="protein sequence ID" value="SPAL_0000442700.1"/>
        <property type="gene ID" value="SPAL_0000442700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040192">
        <property type="entry name" value="CUEDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467">
        <property type="entry name" value="CUE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467:SF3">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000442700.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32351" checksum="B947578AC9160639" modified="2015-12-09" version="1">MTSTLTNDEMSFEDAMSHFCAMFPLVPRNVIQETIQRRYGEIDYVLEDLLKYSERLQQSSSRESFTNNRNNVNIQNSSPPSYDSVMGIVDTSNDEIIAKMMQDEEFRRFAESDKELRELLSRDNLHYHERRKNVVPRLQQPPVRGSQSRNDRIFDDVMLAVPNGPIVDYDTDSNVPNGPVICEGFKNYTTFKEKLSNKFKTLRKSSTTLTGANTSKVFENEIPDERDIYPNTGAFEYDFRDYQHTSRVREMGKASKDKLMKLVARFKATRYANVHYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEZ9</accession>
    <name>A0A0N5BEZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000456900.1">
        <property type="protein sequence ID" value="SPAL_0000456900.1"/>
        <property type="gene ID" value="SPAL_0000456900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894166" evidence="1">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="2">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="3">
        <location>
            <begin position="331"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000456900.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="51422" checksum="5F1305E0E6B0BF05" modified="2015-12-09" version="1">MVFINILFFTTLYVLITLNNCSNKWPNGTIPYIFDQKLRTNYLQKYSLFNTLIDLNKRTCLRFVPKKEKDTNFVEFRYYTRNPSCWNFLTYSNGSNIVAGGPACLSPKNLFHKHNFTDCDIQYINLLYKCPKFIPQLLNCNSSYTILTDKKVKNLYKFNEKKQKWFGNNESFKKYDVNKKDNFLNVTTKDIKELLRLYKKTNNTSLNSIFTKKVQLPTIKSSTIPIPKATSFIETTTSTMTTTKQTKVINDTCDINCNFNIYLKRLFVLHNGNFNVRDTMLESDTLSLKQLQTDNYILQSKEKIFFLNKFSIFLDGDAFISKMENNDSCSCTVPLYRLFNSIISDHFYTTNETELRSARAINGYKFEKIEGYCSQNAGCGALLPLYRFYNPLINDHLYTTDGKEMLFYKNNLIYGYIFERIECYLWNRQNIIKYCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF58</accession>
    <name>A0A0N5BF58_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF58"/>
    <dbReference type="STRING" id="174720.A0A0N5BF58"/>
    <dbReference type="WBParaSite" id="SPAL_0000462600.1">
        <property type="protein sequence ID" value="SPAL_0000462600.1"/>
        <property type="gene ID" value="SPAL_0000462600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000462600.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="53172" checksum="6B0D38B3834C5B6D" modified="2015-12-09" version="1">MIHRAPLSRKASTSSLSSLYSARRSSAVSCSDLIRLQDSFKRKRSFSNNLLTLLLLCSCPLLFLYHYIVQYFLGSIKEALKVLLFTDHFIQTRITVVAVLFPLILVCFHIILQSILPAELHTVLNYDGTYQKQRLNSFTSSCLFTLFYILGSGLRLYDGDIVFINWIPISFFNSLIILFILLITIGRNHIKHQESTSLLSDLFFGINLSPKFLDIDIKKFVTHQLATSLWLVYIVSAVLYAKKNQKQLNDTVICVSLLQITYIFKFLWNEHLFYANLDAQNDRMGFYRTWGVIVFIPTIYTTPVTIAANLTKSMNPFFYNFTVFGMGLFAITMTYYVDTQKYKFRFSRGRYKIMGKDPFFIVAKSRKENGDIQTSLLLGSGFWGITRKINYSFEWLTVISWILLLGKATPLLGLFPVLFITIFLIGRALRDEQRCLQKYGNYWVQYCHRVPFVFIPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG07</accession>
    <name>A0A0N5BG07_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG07"/>
    <dbReference type="STRING" id="174720.A0A0N5BG07"/>
    <dbReference type="WBParaSite" id="SPAL_0000491500.1">
        <property type="protein sequence ID" value="SPAL_0000491500.1"/>
        <property type="gene ID" value="SPAL_0000491500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000669">
        <property type="entry name" value="Tau TuBulin Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000491500.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34770" checksum="036C7A0881CBFE31" modified="2015-12-09" version="1">MAAELVQLQPGQQVDQWTIVKKLGEGGFGAVYKVTNGNGEYALKVEGCNEQIQVLKMEVYVLTEVGKRNGRHFCKIEDKGRSAMGFNWICITLVGKSLQDLRKLGPGQHLSMGSAIGVSIQALEALEDLHGIGYLHRDVKPGNYTVGRPELNELRKVYVLDFGMARKFTNDQGVIRKPRAAAGFRGTVRYAPISCHLQRELCRKDDIETWIYMAVELTSGNLPWKNTQDMNQVGEYKKRCRQEPYIKELFAGCPREYVEIMQITDSLKYYDAPNYQVIYGLMRRAFTSMNVQEFPYDWEKPQGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGP5</accession>
    <name>A0A0N5BGP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGP5"/>
    <dbReference type="WBParaSite" id="SPAL_0000514500.1">
        <property type="protein sequence ID" value="SPAL_0000514500.1"/>
        <property type="gene ID" value="SPAL_0000514500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000514500.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36941" checksum="1116116071F67451" modified="2015-12-09" version="1">MDKISVSEPGVGSSEDDKSIFPISKALDIQDGKKTIEEDNENVGEVTTLEKQENNGQVLMTNDGENLNDATKYLLQFYQSPSPRFQQPGKSRQSQQCRQRQKRPQSFDKRMMQLLINAPIIPNGWNVMKYTVNLDNIVYVKNKHSIYSPVYYKAAFMMSDQVYFSVDDVYQSTKLNDLCGQVFAQVYLRKTTVGEKRAFVRDCIEFLGISKEKVIDWRNTKGLDVIIKATFNKFTQNEELLEIMKKDRNKLICNIFGDDSIDGCGTQKDVEIWADRAKGTTCIIPCEATPINLHNFPTIGCGKNIQGVIIMIVRHMISLQYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIT4</accession>
    <name>A0A0N5BIT4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIT4"/>
    <dbReference type="WBParaSite" id="SPAL_0000586400.1">
        <property type="protein sequence ID" value="SPAL_0000586400.1"/>
        <property type="gene ID" value="SPAL_0000586400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000586400.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42917" checksum="016D3C424F29B880" modified="2015-12-09" version="1">MDENNSTDNQELQCMPTESYDFLRFALVLYVGTPISILGIIFNFILIRLFSISQKIFSSSLYLLVLAILDLFICFMYIPFFTVDALAIYLKLPLFHDVYHKYVMFLYGVSKQTQFASTYVILFGTLERFIMIANIESLSYLITSRGRFKVIISIMITSFLLRLPSYFEYSIEYLEGCLPFENYGYNPILADYDFYPTFSFYVFNIFHVMVPFILLLSLNIMIVTFTKKKISKVPWKHKDFTQLPKIAALLRKECASQSDKKQRDEIRYQTRTIIFIVTTYLTCNLPSFFLTVLEKLYPKSPLIINEDETSSRFYTLCSDAISILVCVNSVLRIFIYYAGNPVLRDQLNKLTWKDKKTDNLEAEPTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIX1</accession>
    <name>A0A0N5BIX1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIX1"/>
    <dbReference type="STRING" id="174720.A0A0N5BIX1"/>
    <dbReference type="WBParaSite" id="SPAL_0000590100.1">
        <property type="protein sequence ID" value="SPAL_0000590100.1"/>
        <property type="gene ID" value="SPAL_0000590100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="246"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000590100.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51430" checksum="506499EA86CD0A0D" modified="2015-12-09" version="1">MSESAVSVPDAKFSDLGLGSWLVNQLKEMQIKKPTPVQVNCIPKVLEGVDVLGCSKTGTGKTLAFALPILQKLSIDPYGIYALIITPTRELAFQISDQLIALGKPISLRCSTIVGGRSQNIQATELSKKPHIVVGTPGRIEDHIRSDPNGIARYFSKIKFLVLDEADQLLDGQYSLQLKSIFMTLPKERQTLLFSATITSALTKLHQVSVSKPYFFEDVDDIKTVDKLTQKYVLCPVGVKDAYLVYVVKNYVEQNEESSVLIFTYTCKEAQALAIMFNALGFSVSSLHSEISQKDRMSAISKFRNGNVKVLICTDVAARGLDIPKVDLVVNHNIPRCTKTYLHRVGRSARAGRVGGALTFVTQYDISLLQAVEGAVGKKLDELKVDDKKITEYASQVLTMKKEAEIKLDQRSFGEKKKINRRKDMIRSGLDDSEVDKVIKDQRKRRKELKNKNNSKKVKANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJC6</accession>
    <name>A0A0N5BJC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJC6"/>
    <dbReference type="WBParaSite" id="SPAL_0000605200.1">
        <property type="protein sequence ID" value="SPAL_0000605200.1"/>
        <property type="gene ID" value="SPAL_0000605200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF15">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894460" evidence="2">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000605200.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26706" checksum="82D3F924E164A438" modified="2015-12-09" version="1">MVCIKNQFSILFYFIFLINKYIDASNSKTCTQADDCRNNTKCISYDKENYCVLPCKKDNEKDQCGEKNKCLEKDDIEGRQQWICNTKKGCLTDNECAKISPKSTCNLYNLQCTSTEEDKKTTTNDTTTTTIYTTKRTTPKKINTTKKPECVDKVPPGPNGCSKLSDYCNDTNYKEMLVELCPKTCGNCNGTGIGITKSKSECKDNISTCSNKLYLCKIDSYRDLMKTVCKKSCNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJV3</accession>
    <name>A0A0N5BJV3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythrocyte membrane protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000622100.1">
        <property type="protein sequence ID" value="SPAL_0000622100.1"/>
        <property type="gene ID" value="SPAL_0000622100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000622100.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12762" checksum="7D9652F48A3AB346" modified="2015-12-09" version="1">XDYSNCPKEFNGNRWLVVDEDDRIEACNKTFTDDFIYRDYNITNIEKKRSETKQNCKVTEYLYTLNKNNSHDEKKYRRLYITERYSEKSDCYRPFFGEAPECGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL01</accession>
    <name>A0A0N5BL01_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">U1 snRNP-binding protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">U11/U12 small nuclear ribonucleoprotein 35 kDa protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL01"/>
    <dbReference type="STRING" id="174720.A0A0N5BL01"/>
    <dbReference type="WBParaSite" id="SPAL_0000660400.1">
        <property type="protein sequence ID" value="SPAL_0000660400.1"/>
        <property type="gene ID" value="SPAL_0000660400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000132">
        <property type="entry name" value="Small nuclear ribonucleoprotein U11/U12 subunit 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000660400.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38571" checksum="D52AFDBAB52FD051" modified="2015-12-09" version="1">MTQFLPEQLLALFFPRPPLPFLPPVSPLLVEKDPIKYSGVGQYLSLFEDPKDTPAKEIVQTKEEKKAEKRKQKESLLAFKLEQEIAAYHTKDTSSFTENPFKTLFVCRLSYETTESKLRREFSKWGTIVNIKIVCTKDEKPRGYAFIEYSRKSEMSQAYKEADGIKIDGVRVLVDYERGRTRKDWLPRRLGGGKGKTRINVEKKVDDYYDDKTSYSKSSSSHNGKRDDKYYPRHDYGDRNHGSYHRSNDDRRFRDDRRDYDDRRKKYDRNVDFRRPSSKFDDNNRNSSGRSYKSFRDDPSNNKRPVMDGDKNGPPAKRYAHSGDVQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL42</accession>
    <name>A0A0N5BL42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL42"/>
    <dbReference type="STRING" id="174720.A0A0N5BL42"/>
    <dbReference type="WBParaSite" id="SPAL_0000664300.1">
        <property type="protein sequence ID" value="SPAL_0000664300.1"/>
        <property type="gene ID" value="SPAL_0000664300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000664300.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10203" checksum="3D969C9A345082E0" modified="2015-12-09" version="1">MQRGKGQLLNALCVGGLRNSKGLILTSIFKRDDKIRSHFSKLVLKKLGKLKYGVLSHSPYSPDLFLTISDLFEHFDVFFKDKLFKNQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLC2</accession>
    <name>A0A0N5BLC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BLC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000672100.1">
        <property type="protein sequence ID" value="SPAL_0000672100.1"/>
        <property type="gene ID" value="SPAL_0000672100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="187"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000672100.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56611" checksum="935E1E4BFBCC93F9" modified="2015-12-09" version="1">MIQAIXXXXXXXADVYMYMSWNDPALAHNLDHTILINSPSVLTTIWRPDLYFSNSRSASFHEVTVPNFSMFVDRHGTIAYGTRITLNVACTLVLKDYPFDNQFCVIKVLSYAYITKLMNVTWFKDDPILYNDEIGLPEFDIIEINNSYCNGTYKYARTDTSFKRDTFNCLTLNIHLRRSIGYHVVQTFIPTALIVIISWVSFWIDRRAVPARISLAFSTLLALTTQSNGIRFGLPQVSYAKAVDYWFGACMVFVFGTLLQYAFVNNYVRRSEKFDKLSQVLKKNAKIMADHHNKKHLDAAKNYDKRKKSLATDELRKKNGSIERRVSENRDFPAYHVNSEKVSFIPHKYSQNLYNVNRRESINYLMKRLGNSCSPQNRRRYYENGGISDEHHFIGKKGIDFSEINDPLENMDIEERIFLQSAIIEEDIQGKGNLTSIELSEIFHDLSRDFSKKSFNLDVYSRIAFPLLFLLFNGFYWSKYLIIHQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMN7</accession>
    <name>A0A0N5BMN7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PET117</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMN7"/>
    <dbReference type="WBParaSite" id="SPAL_0000717600.1">
        <property type="protein sequence ID" value="SPAL_0000717600.1"/>
        <property type="gene ID" value="SPAL_0000717600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000717600.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9750" checksum="2CDC0B48B2627703" modified="2015-12-09" version="1">MLDTKSIPPPPPTKMYGKKVFIAACIFSTLTIAFVMWDEKQQRERRQVSVNYRMLNQQQQSNMEEYKLQKQKYEEYKESHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNM4</accession>
    <name>A0A0N5BNM4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNM4"/>
    <dbReference type="WBParaSite" id="SPAL_0000750200.1">
        <property type="protein sequence ID" value="SPAL_0000750200.1"/>
        <property type="gene ID" value="SPAL_0000750200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894671" evidence="2">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750200.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24673" checksum="BAC84CE1C28E40F6" modified="2015-12-09" version="1">MFIVSLLLFYYSIPLIIVRSAVFRNDERSYNQRRENFDKEFKGYQMGQFNTRDIPKINGPISREVIFRSREKCFQKCLVPCGEVTASLSFDDDEGDFPQDILFKCLRLKPPEKGGFRHLISTSPPLIAAAVLLIAIILMLLICIMCSIVGSCKRRRRLERNRLPTFNTENIEPIDNMEPNRYVKVSADRNGLIKIDETEDTDFGECKKVTSSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPZ2</accession>
    <name>A0A0N5BPZ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPZ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPZ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000796700.1">
        <property type="protein sequence ID" value="SPAL_0000796700.1"/>
        <property type="gene ID" value="SPAL_0000796700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000796700.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="40019" checksum="885E628E94F013EE" modified="2015-12-09" version="1">MIINIDKRKSLGIIAVYAPTNCYDDIDKDEFYLQLHSLYAKVRQMSTVTILAGDFNGTIDSQTIPKIKGRYSYDELNDNGERLINFCTQNRISIVNSFFKKRWWKKFSWIKPQSIEDNIKGRLCVKQLDYFLCNMKRIFTDVETWSHKKFDATVSDHRLVKATIKFPKKLCDYTKKSRCLQKKVLHYNIKYEKSLNEVGEKELIIPSNEFKNVEKEYSKFIKEIKRVTKLVTVEKQIPSTRYSEHVKSLFSNRRKLLNSISYSDNNEDKKESKVKILIEIRLINKLIRQTIKNEWNSLVHNRIKEALENNKKIKSVFRVLKERKEALPVKVSEGFQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ66</accession>
    <name>A0A0N5BQ66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein G12</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ66"/>
    <dbReference type="WBParaSite" id="SPAL_0000803600.1">
        <property type="protein sequence ID" value="SPAL_0000803600.1"/>
        <property type="gene ID" value="SPAL_0000803600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000803600.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23609" checksum="87CDCDF53B4D8F5C" modified="2015-12-09" version="1">MDIRNYFKVYLPYILWLTITFSITISAEELTPKIKLVRRIRNLLTDFLTEEQCIYFIDTYLEMYNNGATMEDIKNDVMTNAMDQLEDDQLLKALGAYKKASKSLGMDKLMTIGTTCINVLMNNVTPFMKQVMEKVQIMKEQNKGKNSINNNMFLMANQFFTKNRVRTIFKRIKNKIGKEDFDLAFPFLSDFMKFDLISDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRZ7</accession>
    <name>A0A0N5BRZ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRZ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BRZ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000864300.1">
        <property type="protein sequence ID" value="SPAL_0000864300.1"/>
        <property type="gene ID" value="SPAL_0000864300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF428">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000864300.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="33158" checksum="7B974DD97300238D" modified="2015-12-09" version="1">MKNIALFSLASSTIVILFCLISAVYIHYEIQNASQQMIFDIKNFKDIINKSWESMNHIKIRKREVNYGGLKNNYVFSPQEQTIIKPEDEDIVLPPNLPPSHPMGLPPAGNNPQDACNCRTGRDNKCPAGPPGPKGAPGPPGLPGLPGIDGKKGVDAEDITRETIEATFCITCPAGPQGPPGSIGKPGRRGNKGRNGDAGNRGRDGHPGRPGEMGLQGNPGNEGPPGSPGEKGHDARALIGRPGLRGNRGAPGPAGPPGKPGKTAPQGPPGPVGRPGNKGPVGPPGPTGPQGLPGKPGRPGRDSEYCPCPVFDTAKKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS93</accession>
    <name>A0A0N5BS93_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS93"/>
    <dbReference type="STRING" id="174720.A0A0N5BS93"/>
    <dbReference type="WBParaSite" id="SPAL_0000873800.1">
        <property type="protein sequence ID" value="SPAL_0000873800.1"/>
        <property type="gene ID" value="SPAL_0000873800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026112">
        <property type="entry name" value="AMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995">
        <property type="entry name" value="AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995:SF2">
        <property type="entry name" value="PROTEIN AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894785" description="Protein amnionless" evidence="10">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000873800.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21351" checksum="0DD517494FDF429F" modified="2015-12-09" version="1">MKNLPLFLLIANLLIIRISSSYVYELIFSNDFESELGWKNYKVPCENDIILFEKNKTNIISINQHFKASSIVLPDNGVLYIGDNVKIGKKGRWQCQKNDIPQQRNFNISSRDRPNFYDPIHWKIKEREYHKDYLNRESLLHFQRVPDSRSTVVIPYGVAAQIQSKRTIKFQSLINRYQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTF9</accession>
    <name>A0A0N5BTF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTF9"/>
    <dbReference type="STRING" id="174720.A0A0N5BTF9"/>
    <dbReference type="WBParaSite" id="SPAL_0000914100.1">
        <property type="protein sequence ID" value="SPAL_0000914100.1"/>
        <property type="gene ID" value="SPAL_0000914100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894830" evidence="1">
        <location>
            <begin position="24"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="4">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="3">
        <location>
            <begin position="222"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="2">
        <location>
            <begin position="330"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000914100.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52362" checksum="7740B972D44C73C2" modified="2015-12-09" version="1">MSSTLLLPTIASALMLLSNYAQGIGHRKFFPPVFKDITETTFPITATAGNTSDVVIVKCPLKGYQHNIKGDSFEVDESIENSTLMIKNGNKELSWIPLMKESLGSKIFKCGRVNLKKSEFDFKGFEWSYKVKWGNALNAEEITIKERIGTDLSDTHKKCNASRQDTLIFTNMKEGGITKVDPVELHNPYVNQKFYYFVKPNENNKDIIKEPCGITKGYNRAPSIIILNHENLPDELKPGQIKTINTEGTEKTKKNFNVQLQLKNNLNFYRGEKISLTKIRYLEGGSKLIKNSGIIVTSNITIEGYELIKMEYVYEGETTKEVISKMYYFGPSSVDFKIDKADVPYVKGDTTGQPNCSAYYMTVGYLEGIRYNGKKYPKDAPSTNEKFEKSGDFYLLKGNHDSSVFLECIYRTPGGKITTRTNFVVKESEKKIETSSNLNINICNAYNIVLVSSLFIMILRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTL4</accession>
    <name>A0A0N5BTL4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase ltn1 and nemf. The complex probably also contains tcf25 as well as vcp/p97 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="STRING" id="174720.A0A0N5BTL4"/>
    <dbReference type="WBParaSite" id="SPAL_0000919600.1">
        <property type="protein sequence ID" value="SPAL_0000919600.1"/>
        <property type="gene ID" value="SPAL_0000919600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="1403"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000919600.1"/>
        </source>
    </evidence>
    <sequence length="1454" mass="168210" checksum="A541B300AD834CF6" modified="2015-12-09" version="1">MKKGTGGGKIKTASSLRAAENLISKGFSGGFIGFNAVSGGNVDVPVEEGELIIENLGDEYSHELKVLLKKIEKKDKLTKEKGIKEVKEIVMKNDVKENKIIYDAYALMFPKLSGHASPTIRSLSVDLLKILISSLKKDASKKLKLVMPYVLFLTSDMSSQVKRQSDSLIEVCFPGKRNQIFVTFKEQLDDLCMEVISKNHKLMKPQKFVEDETDKQRESRLIAQSLGTLLKLIDTSNDPEYNKKLSEKFSNPVIINHLTSLGSIVKATYLELILKLSKDNEDTFLVTKLPSIILSNLDNDDIPLCKAAFSCFLKFAQNDKYFERVDINKAIIPKIIKIVRRCYIKWSFISDNLLPVFDIICRRNKEKKQYFTESVLDGLLEREIEKKTADSFVQSINEIYKYSMFTCGGDMDMVDYLLEYFKKLLNYCFEVDDCVVTKCVLDLGIWIFKKGKDKQIMGDDKFDMLVDYIVKGLVEKFPKFEDFAVKFYEGSGCEKFKKELLKSPQISTELYLSLTEKKSGDNQNVSLEPLFKRFEETEDQTIKVQILQKSLNESGKEELCEYFEKHLNLDDPFTCLAVIQAIDDNNINKINITTVRNCILVIYNAVGAKQISGLVYESLKHLYKYFDDNVYESAFTSLVKVPSPDVYLALLDLLADGNYHPDIGENLICFLFKILTKIKKTVSQECGEKLRIIYDKYNDGSFDIEEINEIYEKFLRDRKTSRILEFSENAIIVSNCKFMPFLIWDEKFEEYSEFLSMNFYSLLYDEVKEIDYQGCVVDDDIEEVIMLLLKKCLVISKIIENSMGYDEESGKKSTLFVLAFNRVLQLIKQNSYMDDPDMDYVFDIKKFSSDELLLILPSKYKNFPCYYQLLTKKEETEVKVPTSKEIRGLIESGELKDKIYLDDDWEEWLFLYTDDEKKLKSFNYILEIFLQDANIFNITSLENADDFRVCGLVTLFSYAAENIDNLLSDKNTIPLQLYRIAIKLGCDIITKREKAAKEIRGYHTVAENYEIKEWVFVIQSVFPNILKIFLDLNNMSPSFYLSNIHLINSISKCIITLIDQVKTDEIVQEPNMTIEESTKKYIYIFTELMQNKLSAHVQIVAASLFHSVLPLYFYYENKKLVDETKKECENITSEKCVPILPPVITALLKKVNLEELKVENETNGPPTTYIPFELLLWNSLIYFFKTLEDDEKLLYMEALDNELVSIGLGIAMFYLPDVPFSREKSSKKHFKELPKFRNSPDDPYFTLSNYACYVFFQTLKTIPVFIRQWLNLLPNSTKAHIKEYIVKYFSPSIIEDELNNSSTWKEKSGSRLSIKVYKVIKTIEAYYEIEHGSGMNLRVILQDDYPLSLPVVETDKSVVAKKINNKWLMQVSTYISHQNGLVISGLQQWKRNFDKHLEGVENCSICIMIVNSVNNQLPRVKCKQCKHKFHAQCLYKWFDTSNNASCPLCRSEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUU1</accession>
    <name>A0A0N5BUU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000960900.1">
        <property type="protein sequence ID" value="SPAL_0000960900.1"/>
        <property type="gene ID" value="SPAL_0000960900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000960900.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24936" checksum="6129B3EF0E2EF9A0" modified="2015-12-09" version="1">MDQDNHIFSNLSEFFNMNINGATCYFNGTEYKEVLQKLCSKLNKPLDSSQMAGIDIRKFETYAGSIIYDGHSGKCLLTKGDMNLEVRVTTSEVKDRINEINNNHNYKGLNQFKTPVSTMKSVSTFCAENNSSATPIRRPDLSTNTLKRKNLNPKSFVTPFKKSVVLSTHHTHQDTSKIGNLDISENGLSIIECTLDVMFETQNAMKLEVNQITQFTNFSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW01</accession>
    <name>A0A0N5BW01_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW01"/>
    <dbReference type="STRING" id="174720.A0A0N5BW01"/>
    <dbReference type="WBParaSite" id="SPAL_0001000700.1">
        <property type="protein sequence ID" value="SPAL_0001000700.1"/>
        <property type="gene ID" value="SPAL_0001000700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895077" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001000700.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11089" checksum="6CF7CE630C6CED23" modified="2015-12-09" version="1">MNWKIREKTFSIFVILLLNIISQIQPQGYQEMMEPKPQGKVANMVNDCFNTICKHWIKECHWFCDNILNKETHNRCLDCLGFRGRHCLPCFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW78</accession>
    <name>A0A0N5BW78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI/MSF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW78"/>
    <dbReference type="STRING" id="174720.A0A0N5BW78"/>
    <dbReference type="WBParaSite" id="SPAL_0001008100.1">
        <property type="protein sequence ID" value="SPAL_0001008100.1"/>
        <property type="gene ID" value="SPAL_0001008100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001008100.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23421" checksum="0F86749B935BF90E" modified="2015-12-09" version="1">MKIWHSPLQIFKYTFDDVASAVWNRYPNDYSTHIISEDILESRIEGNKIFIKKLIIKKGSKYLKMIPFGMSSLRSLKIVPCIEESIYDRDSKTLKTYTRNVSYNDKFMMEERCVYSPSVDEYKTSTDLKRSILTHVNYGKFSNLIQKVLLMQYKKRLKGTDSGLIQVLTERTNVSSERVNFFKDSLSSKIENARKYINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWD9</accession>
    <name>A0A0N5BWD9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWD9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWD9"/>
    <dbReference type="WBParaSite" id="SPAL_0001013600.1">
        <property type="protein sequence ID" value="SPAL_0001013600.1"/>
        <property type="gene ID" value="SPAL_0001013600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23625">
        <property type="entry name" value="UIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001013600.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42569" checksum="60EA7A80535B01A9" modified="2015-12-09" version="1">MVQESTMICLDNSAWMRNGDYRPTRFQCQKDAINLLFQCKTRSNPENAVGLLTMADDVRVRSTMTQDDRKLFIKLHEVEIENVSKVIPAIRTAHLALKHRPNKNHKMRIIVFIGSPVQDIDNSDLIKLAKKLKKEKVNVDIVCFGEAAEKNNETFEQFIETLNGKEGKGSNMVIATNGLLTEAIASSAICKNEDGSGGNLINTGSGFEFGIDDADDPDLALALRVSLEEQRQKQRTEAGNTDEGEKMETNTVETSAPDVAFMTEEEQLAWALKMSMADADKPSESDEIPKKEDENPVEDATVKEEAMETEDFTNLMSDPDYLRELVSTLDGVDASQIENAISGSDPSVQLEFMTEEEQIEWAIRQSMNQSDDKKKTDDKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWT0</accession>
    <name>A0A0N5BWT0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BWT0"/>
    <dbReference type="WBParaSite" id="SPAL_0001027000.1">
        <property type="protein sequence ID" value="SPAL_0001027000.1"/>
        <property type="gene ID" value="SPAL_0001027000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001027000.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37238" checksum="7F202949C205B9C9" modified="2015-12-09" version="1">MVQIDEISSYKLQQRPAYCKYFDNFNTIIASTYQLENFQDRSGSFVLFNNQLEKINEIKLEAGVFRFDVDNFQNNQILASLTNGKLGFVNLENSEIKYSKKLSDGMLLNQCQNYKCNNYTIITTDNLGGVFIVDSGKEYEIVESKVVHLLPYVKTPCEVWSCGFLKINDENIFGTGGDDGILKIWDKRQGLNLFIDTFETNDNSGVTFISNSLYNENEYIVGSYDEIFRIFDIRNMKEPKNSIKLNGGIWYIEEHFIDNIQKFYCSCMYGGWNLVENNDNSLSVKISNNNHGKDLLYGVSRVNDYNIVSTTFNDFTIRLESIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY15</accession>
    <name>A0A0N5BY15_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY15"/>
    <dbReference type="WBParaSite" id="SPAL_0001067600.1">
        <property type="protein sequence ID" value="SPAL_0001067600.1"/>
        <property type="gene ID" value="SPAL_0001067600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001067600.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53884" checksum="F21ADB18658C772D" modified="2015-12-09" version="1">MIQRKNIYFDHLKRNVGLNELHNFSNETVDMMLEREVVECFRKISNDKIYPGEDDSINSKNDKRRKRENFNMCKSLGILRTLRKCEDEAKLLLEEAGVYIFESLSKEELAEFLTAKLERERLGKGKSFPSKICHLLSCAKSSVMFDPSVKNINDVPCTCGREVNKSEIENIDKGFSIETFNHFNKIKKMKSKIPRVTSPSTEAYMVITPKSNSCKVVTVNPETNEHEEVSREKPKMEIVKASQQPKIEEIPRIEPKQELPIEYIVEDNIVTHFKSTSRKSKHNENAVFEEGTDAFSYYENETNQVPSPFLEEMGLSPEEIEELKKDRTVVKKIEGLNPGELRIRIINLPERRPSTKEAKEEDIKNVKEEENVSEFPPMWFSTGDSSFQQSGNWLGNNSFLEDPSEIDEEAMKSDEIYNSEDEDENYEFRKRKHSPPLTAVGGDANNKKRMFTYYHTQGHISSSSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYF3</accession>
    <name>A0A0N5BYF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BYF3"/>
    <dbReference type="WBParaSite" id="SPAL_0001081100.1">
        <property type="protein sequence ID" value="SPAL_0001081100.1"/>
        <property type="gene ID" value="SPAL_0001081100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001081100.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35599" checksum="D3E28BCC1E902F65" modified="2015-12-09" version="1">MEQKRTNYKGRKRSYPYDNKIKSNRHKKHFTNNYQNKMSYAFPQNGQCIPQCNVNTYGNGLQFYGSVANNTHLKQATDPQSGYFFNTPLNNKILNVFPPVNYGYYYQNCLNNPYNNNQISAPPVTNNEIKNENDLSRDSLYITNIPFECTAVNLFNLFNFNNLIARYAVSNIPRIKIYKNELMRASSVITFVSPGAANYVKEFMDKKEFPGTYMKMKIKFAVHKKKSGNGDTSDVSPEFSKNSSVPIEEEKESSDVDNKKTEDNNMVGGYIARFETSNDQEKEVTEEKEDNNKECTTNIENPTSSETSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYP4</accession>
    <name>A0A0N5BYP4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYP4"/>
    <dbReference type="WBParaSite" id="SPAL_0001089350.1">
        <property type="protein sequence ID" value="SPAL_0001089350.1"/>
        <property type="gene ID" value="SPAL_0001089350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001089350.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7906" checksum="4DE3BA563D4236E7" modified="2015-12-09" version="1">MSEKSGLSLSVTTPSIADSSTKVVELNSPTTNSKLSEKWSSYSSLDETQFDKSQEKLNRCGCRKEIENMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ42</accession>
    <name>A0A0N5BZ42_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ42"/>
    <dbReference type="WBParaSite" id="SPAL_0001103700.1">
        <property type="protein sequence ID" value="SPAL_0001103700.1"/>
        <property type="gene ID" value="SPAL_0001103700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001103700.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="58635" checksum="7BD5DDDDE76AA85B" modified="2015-12-09" version="1">MDPTEVEEFIDLDGEIPGDNLEELADDDISIILEIPATESEAVQEQNKMISPLHINKKDATATIVNADMDSNNPKKVAAIESVNTIQDLNVPDAAKDVVSNNGTADVPNTMNRSDNSETVNKGNCSSSSKVVKGSSDGVHSNVSKEINDSKLSKVTKGVNDLKNSNVAKGIINPDNYKDKKRRNLNEGAGPIPKHPRGPSKDHSATGSPTADITEATQLRVVEASTSSELSLGDFIAVLEKNTRTIEAQLFMEQLGHVSPKPYGQTMIMSMTSFRFWDSFINAVDGDKWREEADKARRRNKILAKPGVINYGSIGSTQDLEAIYDAIHEVASGSMTMAIIGTRPIMLPSRNIPKWRGMCILHRGGILTGYVPPSLEVLILRGFTSAGVNFDTLLTRSSRLKVLVVDSCQLMAKMWQAICGTSSIQALVCKQRGSCSCARLVANRGYQNQIYLVPEEQNSNYFWKKHHRAQKKIVPEGQKDSYREDKFTLRGHIYYKTPEILPFLCGVLAPAKLVEEAANKKKRSFQLMKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZI6</accession>
    <name>A0A0N5BZI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RT_RNaseH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZI6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZI6"/>
    <dbReference type="WBParaSite" id="SPAL_0001117600.1">
        <property type="protein sequence ID" value="SPAL_0001117600.1"/>
        <property type="gene ID" value="SPAL_0001117600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001117600.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15695" checksum="A82E06B113343E2D" modified="2015-12-09" version="1">METIRNSKIEALKKKTDEAICNLNGMDAIKVFFTIMTVFNFKKVEKRWQVVEKKALALAYAVKQFKYHIESKTTNVFIDQRAVLAIKSPKENQSKLRRYQMALAAYNLNIYYKEGKANVLADMFSRNPEPKQPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0C1</accession>
    <name>A0A0N5C0C1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0C1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0C1"/>
    <dbReference type="WBParaSite" id="SPAL_0001145000.2">
        <property type="protein sequence ID" value="SPAL_0001145000.2"/>
        <property type="gene ID" value="SPAL_0001145000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001145000.2"/>
        </source>
    </evidence>
    <sequence length="694" mass="76969" checksum="C58C3C242080A50E" modified="2015-12-09" version="1">MEQQVVTEENKKAPADIFQGFLDNPLISQVSNTVINTFTEHIKNSNHHEINDKQQDSGVDDIEEAFQKIDHTKKDNNLNDITHDVKEEEKKKEHNPINDFFNNQFGAQIGGFVGNITNNVIETVKNELVDSSFDNVHEDSRSKTPEPTKEEFVLPNDHEKHPQEPSGIDLGKIMSTAQDILANNGDKIHEIVQNIIPSVLNEEHKTETPQEPQTDTSDKSKGNSNNMSIPKVDIIAPSPLPSDRNENAPSEPNHDFKEPSTDDIIDEIQEEFSCVQLKGYTTENNNDESLVDVRDDESNNVEIEKGVNEPSVVDVHEEVLIKKENSHEGENVLVNHEITIQPREEIKHNEPFVEIKQEVEEIKHNEPFVEIKQEVEEVKHNEPFVEIKQEVEEIKHEEPFVEIKQEVEEIKHSEPVIEIKQEVEEKVQIPPPVSVPIQAEVKKTPKTTNDKKTTTTTTTKTTTTQAKPRVPPSTTKTTTKTTTTTTRTVTSSKPTPSKTATPRVTGTEKTVTKTTVTSDKVPSYARPTGASTRASTVGNKSSPSTASSKAGSVTSSSAVRPLPRVTNKYKDVKSKVFTTVTTTQTTTEKPSTKPTPKPPSNGIKPLPKTKLNWKAESKVGSFANIQHKPAGGHVKLINQKLNWNVSSKVGSIDNSLKNKTSNNKPAPPTTKIGDVKAELPGNINPLSAKEALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0X9</accession>
    <name>A0A0N5C0X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0X9"/>
    <dbReference type="WBParaSite" id="SPAL_0001165800.1">
        <property type="protein sequence ID" value="SPAL_0001165800.1"/>
        <property type="gene ID" value="SPAL_0001165800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895272" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001165800.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15613" checksum="2D0F7A3D7F5B57FF" modified="2015-12-09" version="1">MILISILKCFLLLFILKNITKVQSEDDPTHGSHLRCYVGQKIQYWNEEWVENLMAIKCGLSYCSNMTVINTNRNESGKVVIEYSCGGDTLALCDNVTNACLSAGVHNITTCCCDKDLCNTSTFLNSSFSLLLLVFLTQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1C0</accession>
    <name>A0A0N5C1C0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RT_RNaseH_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1C0"/>
    <dbReference type="WBParaSite" id="SPAL_0001179700.1">
        <property type="protein sequence ID" value="SPAL_0001179700.1"/>
        <property type="gene ID" value="SPAL_0001179700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001179700.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25337" checksum="4618EAF806BD65E0" modified="2015-12-09" version="1">MLALSTLKINFKKERNRCNNSVIQFPHLKDAYHIDLKDDIEKYLKSNTEFLPWNEKNELPVIIYADDIVASGSGKNAISYLHLAYKFCDVESGKLEHYKTYGISITKIEKQNNYQDILRHVMEEFNTITFTHNNTVKKLNPIFFIADNLMIQSAFDFKKSFSNKSKNCCRACTIDDEKFHLYTKKLSLDEVLRETPENFFPRNNNIIFDTFHDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1C4</accession>
    <name>A0A0N5C1C4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group-specific protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1C4"/>
    <dbReference type="WBParaSite" id="SPAL_0001180000.1">
        <property type="protein sequence ID" value="SPAL_0001180000.1"/>
        <property type="gene ID" value="SPAL_0001180000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001180000.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15282" checksum="7CA4480418A7AC6A" modified="2015-12-09" version="1">MYTISISYTYYEEINNGFYVSVFGNATWDESNVKDVWATLFNNDRPKPNDTREIKNNRNFTLSTYIGTKIAENNKVSLTVTFDYKKEESKKSLNKTVPEDCLNSNATCFEQTGKRYEAREDCVCYLNTTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1N6</accession>
    <name>A0A0N5C1N6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1N6"/>
    <dbReference type="WBParaSite" id="SPAL_0001190800.1">
        <property type="protein sequence ID" value="SPAL_0001190800.1"/>
        <property type="gene ID" value="SPAL_0001190800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895203" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001190800.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9483" checksum="5142197C3EC272DD" modified="2015-12-09" version="1">MHFIKYFTILVLLAVQYSFQDDTTTYATTPDCTYNCGFGTTQESPSDFVYRKKRSFGKILKTVGKGMAKNLAHKVQSKVKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1R4</accession>
    <name>A0A0N5C1R4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1R4"/>
    <dbReference type="WBParaSite" id="SPAL_0001193500.1">
        <property type="protein sequence ID" value="SPAL_0001193500.1"/>
        <property type="gene ID" value="SPAL_0001193500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895210" evidence="1">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001193500.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="13958" checksum="50B14BF4FB2F342E" modified="2015-12-09" version="1">MKFFNTPYIVAAIAIGMSSMTYGQDWNGMGGYGNGDMGGGFGNNYGGDMGNGYNGGYGGDMGNGFNGGYGGDMGGGFNGGYGGDMGGGYNGGYGGGDMNGGFNGGYGGMNGFGGVMKPMVYNLNNGDVPPGGLYGSMVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Y1</accession>
    <name>A0A0N5C2Y1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Y1"/>
    <dbReference type="STRING" id="174720.A0A0N5C2Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0001233800.1">
        <property type="protein sequence ID" value="SPAL_0001233800.1"/>
        <property type="gene ID" value="SPAL_0001233800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001233800.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49721" checksum="08DF8134FED0F0D6" modified="2015-12-09" version="1">MGQNQFGGQKNRGGDGQDGDKEKKRKYEAPIPTRFGKKKKGKGPSAANKLPVVTPHARCRLRKLKLERVKDYLLMEVEFIKNQEILKPQEERIEEERMKVDDLRGNPMAIGSLEEIIDDTHAIVATNVGSEHYVTIMSFVDKEQLEPGCSVLLNHKTHSVVGVLSDDVDPMVSVMKLEKAPQETYADIGGLDQQIQEIKEAVELPLTHPEYYDEMGIRPPKGVILYGCPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKMVRELFRVAEENAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIESLDPALIRPGRIDRKIEFPLPDERTKRRIFEIHTSKMQLSKDVDLDEFIQAKDELSGADIKAMCTESGLLALRERRMCVTMEDFRKSKENVLYRKKDGAPETLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C318</accession>
    <name>A0A0N5C318_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein TSSC4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C318"/>
    <dbReference type="WBParaSite" id="SPAL_0001237300.1">
        <property type="protein sequence ID" value="SPAL_0001237300.1"/>
        <property type="gene ID" value="SPAL_0001237300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008569">
        <property type="entry name" value="DUF851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05867">
        <property type="entry name" value="DUF851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001237300.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30871" checksum="B1C7B6B31F85207E" modified="2015-12-09" version="1">MSTVDAATQILEKANQLRKKKIEKKNVGDKYPLSTKLFFAVDDKKLKNDIKRKGPPHPYYNLTYRDAVIDTPHELKICNNNRNGGNLFDYKGNPFWHPKFDPKLRVKASLDGLNAEKKQQEIDMSDSSTTDQNLVIKPEDALEYFNGRLQFFEMPPHESLILHPWGPLSAMEAKTQFFTADVIKSNTIKATVDIKKDPETTNKKKNSKESANATSTPIKWGPIPTSITIYNRTKPKEQLNVKFNPKDFHLNKKHNKHSSNTSQDEDTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C334</accession>
    <name>A0A0N5C334_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat EBI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C334"/>
    <dbReference type="STRING" id="174720.A0A0N5C334"/>
    <dbReference type="WBParaSite" id="SPAL_0001238900.1">
        <property type="protein sequence ID" value="SPAL_0001238900.1"/>
        <property type="gene ID" value="SPAL_0001238900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001238900.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33026" checksum="ABDF8A34585498D4" modified="2015-12-09" version="1">MASVFSDELNYLIFRYLSENGFVHTAFAFSCESGVATSDIDYNNVPNGSLITIVQKGILYAHAEVQEFLADKGKSKDEIEGVKLSLIESVTPKNSGVDINQLKQDNNSNSTHQPNGGIDENTSNAINSMMNGLNDYKNMQLPSTSGVLDDSISMDTSNDSDKTKNKDKMNKLNISGIRVKKDIDNRPQQGNRDRLSPINKFHISSLTKGDSTPANTEKDRKDTNIENTIINMSNGINNTSLHSIVSSTNGQLNSLNNTMFQNKFLNQNLPNYTTLKSPASISAPNPTYTSLSNISNGCVNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3K5</accession>
    <name>A0A0N5C3K5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBFD_NFYB_HMF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3K5"/>
    <dbReference type="WBParaSite" id="SPAL_0001254732.1">
        <property type="protein sequence ID" value="SPAL_0001254732.1"/>
        <property type="gene ID" value="SPAL_0001254732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001254732.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12813" checksum="036C0A5CF43C6EF7" modified="2015-12-09" version="1">MEAFKKSLSKSLLQQEEDKLSEEQFKKFEESLVNYYNSHSGLDYTKPAVISTISKYLSSVLEEIRVKKPKEEEGSKIQRTSMKLNLAALQNIESFDGEGSFPDFKSCFETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3L2</accession>
    <name>A0A0N5C3L2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="SPAL_0001255400.1"/>
        <property type="gene ID" value="SPAL_0001255400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
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    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="1130"/>
            <end position="1307"/>
        </location>
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        <location>
            <begin position="1661"/>
            <end position="1818"/>
        </location>
    </feature>
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        <location>
            <begin position="595"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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    <sequence length="1945" mass="223562" checksum="17C5FB5401BD8EB3" modified="2015-12-09" version="1">MDTLRSSKKDLDGAVALEHYFKKGQLDLDVTGVKRFFSRNIKAIITRIPSRVTREYVHREELKDFMATLVENPPGNALSQAYEANKARFPKATFERLVDITRSDCLLMLANQTDFNALRHIRQEAGEPIMKFNTRFYQRVIEVYPEHGRRITEEFSGKEAVFTPTELRSRIQIFNDYVSAIKKPIAEKIPYVDGPGKCLRYAMQKAIAIEADLREFNERTKERNAWIDNTQHRNHKRTAYSYQVAMEQPAHPSYECFNCGKSNHTSSRCPEPIVKCPYCNRSGHMIKYCFKKKNNGRGQNSRGNFGGWKQNTFMAAVIISIVLNLLIGTTEAARWFQPKYIGDYMVETKLPECTNYYIPMVLYDNKLITFKANLELLPARTEDYSSCPCNKKMKGFVYENKRCLSFMNIDVRANPYNKLEFSHRIINDIILQGDSDRMAWALTANKTIGKPRFWAPPKFTTLTAAIIDRVQNKVPDILEAEEMEGYALDHIKEAEKKIREKGIAIPQYSDRESTFQSGSTILGSTINEQTIRTPDSRRMAGESLQSLESQYRENVGGTITNDNINTRNPPHSSSLGVVYQPAVPSVIVRSERPISPPVLRSNAPTRTSDIRSNAPSPSSTTTTHNNVFPSFPETPKTVRDGRVHFSPSINAEGSTRDQIFLSAADKTLDAMIQQRNKNQSDSYDKFNPLVASTALRPQDDSIEKRIAEEREKAFKKNVEKIAILADNLDSKNKIEAFKKEMEEAIYNLNGMDALTVFTFTIMAFFGIYLKKKGWKAIMESILERVKRTPDGGISIETEKTTTKVEEKETEKSETENSVSTKVTRITLNKTNGGDTLREGSMISLGPDDLEIDKLLEMRGYVLNVIGNNNLEMPIVVLKIGKVLMKAYIDDGSEISLMSKRRWIQLGKPKIEESDLVAKNTNAEIPILGKIELNIGVPDKELTKETFFIVEDLHLDVLIGGQPTDDCLLYIKPHKTNSIPFQIQPIRGVNVMKNNQTQLQVWNTTTKPITIMKNTPICLAVQIQPDEIFRAEDEYIAEEANWEEELPDKLLEKPMTNEELMRITEVPEEVRPLIRKYKEIFYEYKHDPGRYNGPIQHQIRLKEDSKPIQHTLRKYKQEHVDAMMATVKDLEANNQVMKSKSAWASPVVMVKKKSGELRKVVDYRQVNLLTKPEVSVLPLIDDLLEKISGKEVYTTIDLAAGFFQIPLEEGSREITAFITPKGLYEYKVTPMGLSGSPATFQRVMEHTFGDLRDFVAVYLDDIIIFGKKSDHAHQLEEVFKRLEATGLKVKLKKTTFLRPRVEFLGHIVSQKGIEIDESKINAIDKLTIPDTRKGLRSFLGATNYFRKFILGYAKVAAPLTKLLSEKVEYLWTEEQSKAFLELKKRLKTAPILAPPDLSRNFIIHTDASEFAIGAVLLQEDKEDKYPRIVSCASRTLQEVEKRWQVVEKEALALVYAVKQFKYYIEGKVTDVFTDQRAVLAIKSPKENQSKLRRYQMALAAYNLNIYYKEGKANVLADLFSRNPEPTQPMVLATHNIMKISKDMDFKEMRTSLNMAGWSTSRQNEEFLQNEMKNQHRRLRNLVIVKVKGIEKFYVPDNERNKLISYIHEHPKLGGHFGVHRIKELIQKYFWWENMEIKLYCETCQKVKFQPNTTVDWKGTWDIPKGPWERLNMDIRGPLPITGRKNEYLLVIADEFSKFTIVIPLRKMNTESIIYEINNQIFSRYGTPKVIRLDNAKYFVSNLFNEFMKNWNVEIRTSIAYNHNSNGLVERSNRTINEIIACYEAEENWDIVVPTVIGVYNNQIHTSTGQKPFEVLHGMTKNNAIDVLSMINHLNQPEELINHEEIISKVREKLSKNRENQEVKKEHIFKEGDVVLKSILDKVGNKKKLQERYDGPFCIMEINEETGDCKLSKITKSGRIAHKKLKGERIYIYAHIKQLKKFRSIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3N1</accession>
    <name>A0A0N5C3N1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3N1"/>
    <dbReference type="WBParaSite" id="SPAL_0001257200.1">
        <property type="protein sequence ID" value="SPAL_0001257200.1"/>
        <property type="gene ID" value="SPAL_0001257200"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001257200.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20634" checksum="8330F1AB59748D02" modified="2015-12-09" version="1">MRVSNVSTVFIIILIFNIVRIFAWKYRIYIKGIPLCWPGKDHEWVLMRLRVGNNWTYFSSYHSHCDKEFFLVTSLSAGIYPIRVDGRVNIVYDDLPWGDTVKDILEDCVYFRTWGNKYCCDYGEFGPPHFTCKLRDKYFCDKAIASPRTKRHLLSPEKSKKPRKSKKSRKSKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4G4</accession>
    <name>A0A0N5C4G4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4G4"/>
    <dbReference type="WBParaSite" id="SPAL_0001284600.1">
        <property type="protein sequence ID" value="SPAL_0001284600.1"/>
        <property type="gene ID" value="SPAL_0001284600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001284600.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31595" checksum="E79A1329615C6568" modified="2015-12-09" version="1">MSTNIIIQRQLDPLKDSSSIEVEDEDENHPTTPTNKQKQPCGRVFSITPVRSAFIAVILSACIIAILYDINIPHKDIFVPLEQNQTVLHTGCGLTVNIGDCNPNECPFGICEARYIRYYDDVSKVDRTKKFCQCVETPMCNLIGMKIHSGCRNYAGLSEIGQEMIRKWSMTAMEKSYNRNLEKRKSRDITLNALIISNNTKSVTKSGKGRRKIRHDKNQQIIYSEDRRHAQLFEGITKFCCRRSNIKTKYMASSMFRSGASTVASNVFILIILFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4I6</accession>
    <name>A0A0N5C4I6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4I6"/>
    <dbReference type="WBParaSite" id="SPAL_0001286800.1">
        <property type="protein sequence ID" value="SPAL_0001286800.1"/>
        <property type="gene ID" value="SPAL_0001286800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001286800.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15763" checksum="4E5C871B4E753609" modified="2015-12-09" version="1">MDNIESDDQGRGEGIISDTIDESVEHRNDVGDISDNFEESYEHLTDGDDDSDLLDGSDGHQSDRGNMRNVQLLGSIRIIICCTRICQCNLGKIRGWQRPYSVKCGPNVIGGPASLYFKTKEDFLCFGDYSGVSRRRHTQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4R9</accession>
    <name>A0A0N5C4R9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4R9"/>
    <dbReference type="STRING" id="174720.A0A0N5C4R9"/>
    <dbReference type="WBParaSite" id="SPAL_0001295000.1">
        <property type="protein sequence ID" value="SPAL_0001295000.1"/>
        <property type="gene ID" value="SPAL_0001295000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="158"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="323"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001295000.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65121" checksum="636B8E68D7F614E2" modified="2015-12-09" version="1">MWNVKKYFNRPRSRSIDSIENNEFMLIEAVKACDIRRIVYIYSFETIEQKMATVGNDNILHLAVATENAPIVKCILLFYEKKFNFSKQRNKQGLRPIDMANKEIETIFRQWDGEINVSGESYKSDASGESVSEMRKKLNASILLQRLGQLTNKSKVLMSIDGGGIRGLAAIQVLMTLEDELGVPLVDVVDWVAGTSTGAYIAIMLSQKKTLEEMRKIYLRFKGKVFRGMRPYNTAILEKTLQDILGNEPFINIKKPKLIVTTCSIKNSMPQLKLFRNYKSISDSTNESSGTHEKDFENFSAWEVGRSSSAAPTYFEPYKGFIDGGIMSNNPALELLTEFFEHNYSTTMNKNLSKISSDSSSSEKDEKYLTEIKDKTTQLTKNLWPTSACLRKSNKSEEPTEDKMENIACLISIGTGGWKANMKEGEPNAILHHLPPSNGTNNGSTTNIINNNNTTTTNHNSSNNNEPQKKNILKKLADLKGILPVFVRQLTASDGLPVERARAWCHSIGVPYFRFTASHTIRLKLDDSNDIGIIQMMWDTEIYLRTDGKGEIARLTNYLKLFSKMKENLDVKKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5B3</accession>
    <name>A0A0N5C5B3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec7_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C5B3"/>
    <dbReference type="WBParaSite" id="SPAL_0001314200.1">
        <property type="protein sequence ID" value="SPAL_0001314200.1"/>
        <property type="gene ID" value="SPAL_0001314200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001314200.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31272" checksum="0932F6DB51033813" modified="2015-12-09" version="1">XTNFCFYNKELGHPSNSMAEFQGGIDHILKNGGNNWIDFTDFNERVNLEFPLDETILSKLLNDFVLKYSDDICRGNITSDMLEDICRCRELLLGVDNGFHAKEDNSKSYEDYKSFINKIIDPKICQNEATEEETSSETPKWMTKLRSLIIEFLASSFVICSDNVMIQIYDAIHWYSILVLNSRQTDPDIQTNIFHLLSKFIFRLPEDLKMEFIKQGGFYIIGSQINNLTVINMTIINSLFSLMCLECVDVSQGLDDNYQFIIFINVPRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6G1</accession>
    <name>A0A0N5C6G1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6G1"/>
    <dbReference type="WBParaSite" id="SPAL_0001352900.1">
        <property type="protein sequence ID" value="SPAL_0001352900.1"/>
        <property type="gene ID" value="SPAL_0001352900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001352900.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19904" checksum="1F478B34E8E69ACD" modified="2015-12-09" version="1">MYHPTSNKLIVNSDALKEPSFSRYFPNSLNYGYIGFTIAREILRAFDNDNRNKSNVTQFSIEHFKEKSDCFTKQYRLQKENMTDKYIDDLTTLAENIVDNGGLKIAHRAYKKYLQSISEDQINKDAHAPGEIRTIITLSNYKPFSNAFKCKLNTTMNPVDKCEVWKNQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C740</accession>
    <name>A0A0N5C740_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C740"/>
    <dbReference type="WBParaSite" id="SPAL_0001375500.1">
        <property type="protein sequence ID" value="SPAL_0001375500.1"/>
        <property type="gene ID" value="SPAL_0001375500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001375500.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="48172" checksum="C40A66F7E2BFFAAA" modified="2015-12-09" version="1">MSFEDIKIATRNLCLSYDKVKNTLNIKCLRSVEELIGNNETSITKFAGYLIRICSKKNYIFRLSSIVVADYFIRKCDTFALYYLSWSYCLLDKIVFFNLPNDDESDKDDYKLMKERSRSIVEKWIQDLGTKFIKLQTIGEFFVKEDEKQKLIEIENDKKLMSVFLKHCELAQKHYEELSSEMDVIFKRMDELMEELIPNELKNFQMPSSEVGGGLTSDINLSKAHGYDIDTEVQVFLRKDCFKVTITDENRGIFNELNKLHKRSCEIAKSLTRKIERLCESGNKFEKAFCDKCFNLREKIRRYIQKCNDIGVDRFYKDDVEDSDVKSDNDSDFEDVDIDDTDYLIPSKVTKQTKEDTIHVNIKIENLDKLKFNPYIKLNTDSNSLKKEKPKTSGNVEKNILSKFAALKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7D2</accession>
    <name>A0A0N5C7D2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7D2"/>
    <dbReference type="STRING" id="174720.A0A0N5C7D2"/>
    <dbReference type="WBParaSite" id="SPAL_0001384600.1">
        <property type="protein sequence ID" value="SPAL_0001384600.1"/>
        <property type="gene ID" value="SPAL_0001384600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="3">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="195"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001384600.1"/>
        </source>
    </evidence>
    <sequence length="740" mass="86192" checksum="F35249D7E0FBF272" modified="2015-12-09" version="1">MLGNITNDDNVFLTKDGLFNHFCIIGQDDFGSMNEVSNPINNNKKPPITDIDIIIPNLLEEIPENFEIITTTYGGSSANLFGKNLVLKECYIIFKRGYDKPPIIDIGIIDKAKNEQSTSDSVILSKTRYGNSANLSNTITGKMYLIYKRASVDYSLDDMVVGDICVINESKNEKVPGNFFKIPKSINKGIINNEIFICYRKEKIKQKEILFNAKLLDSFPKFDDINSINILPMFCMPEGTRILCWRDTKKHPSPFTNTFILTEKDGRRVYGTTYGFYEKFNGDLSDDQLERLGIKRYNDSYIDKDEVTYQLYKNISISFISNLPYFDSFHMILQYIRKMVYDNNNFCIERFLSNLLYEIVYPIPKNPHFKLALGREEVFFNFSNFNDFPICGSSYVDTLRLIGPINLMILVVSAITERNIIFHSMRSHLITIICESITSLMFPFFWDFPYIPHCPLESFTIFECPCPYIVGVDSKYFDEITNYPKETICFGIDTNTISLTKDEIKKIYNSLPMHSAKYLRVSLTEVYNELMEEDGRLKNIKNSPDPLVHMSLKKHFFNINSIYNKRIKEIFLRFMCSLLIGYEFHFKPINNETPDSINRLMRSIYDFDGFISRKPKICKEFYKKLCATQAFVSLIQEKVTKSDRSKYYTFFNSILLRFINDVDEQLLEDEGYDDVLAKIPLYHVKTFKKDTDKKGRKMFPLKFDDNLFDIQNILMSIKSNDKNGILQNIVNSEEDTFSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7R3</accession>
    <name>A0A0N5C7R3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCM1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7R3"/>
    <dbReference type="STRING" id="174720.A0A0N5C7R3"/>
    <dbReference type="WBParaSite" id="SPAL_0001397400.1">
        <property type="protein sequence ID" value="SPAL_0001397400.1"/>
        <property type="gene ID" value="SPAL_0001397400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001397400.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="101539" checksum="C4DADF971563C46B" modified="2015-12-09" version="1">MDLKQLPLNEREELCYERLSTLREKKAKLENGIKTVSSTKIDNCSEEVISSIKEMKEKLESSLNLLIKQENDYLGILAHIKAMRKIHEEEDDKEDDEVTIEDVHQELKNIKDAMEKTEAASKINQQLMMTLKLQQQKRAALAGINLKKRQEQSIAADQATEEFLTAKKKFLTQKTEIERKNIQLEKLKREIVKRELLGRCDIDNESVVINKSNPDQQKCAEKVSTKSSKENDQKNKDIFNEIEPFVDEENCEMINDEEDDDEDEYSHLSLSEMKERRDAFNEQITTKLRVLEENKNRMRLIREKLIGLQKDSYKNMSQDNTKKPEDTKIEEPKESLDNKKKIDIDYEDALSRLQSLTSMRQRLELIHQNITEDGVIDKDVKIMSVPDIVLSEINEVVSSNKEMMDNYGKSNSTEKGNRASSPSPDAATPNCITNALDDPYHGGKDAQKYLNSTESSFDVTTIENVIKKGNKMEKNIRNDDESELISVVRKEFQNSMDKKNSVPSKLKHCGFSTSFSTINTSQDISDDKTPIGDTSTINEQLEKMEEILNMHSLKLEEISKQVNSFSATTNCHNSSGSVPPKSPITLPTNLNGELLKDLVTNLFTNASKEALRNFNEFLNKLCINQCLVGELSENVQKLIESCSHSSPDIKSFSKDSKSPSEEVLEDDGFDVKEMPLFKNDSPLLKKNSTYWSHGYWDAEEQEGLDFIDALRESQYDNCVNNETTKLSKMKTREKVLKFTSSLRKSSSEELTTSGETDSRNEYKNVENTRNEECSVVEEQIFFIVSSIIPFLNIQQQTSPTADLRFIADLRNLILNETRSIYCKNMDIKSSQTFTKQISSILDASLSSYIGCNISENRDQLILELSDVLHNELSFYNLINDINNVFIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8T7</accession>
    <name>A0A0N5C8T7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Multidrug resistance-associated protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C8T7"/>
    <dbReference type="WBParaSite" id="SPAL_0001432400.1">
        <property type="protein sequence ID" value="SPAL_0001432400.1"/>
        <property type="gene ID" value="SPAL_0001432400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000015">
        <property type="entry name" value="multidrug resistance-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000162">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="133"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="476"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="768"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001432400.1"/>
        </source>
    </evidence>
    <sequence length="1349" mass="152047" checksum="A74F233231C3BD91" modified="2015-12-09" version="1">MSSSQQMTEISASNRNSKILNDEDTKKNGPQIPLVTNSKHTTYETGRTNNFLTNLDRANWLSYSTFSWVLPFLYKIKSGKTESSVPFGVPLFDSIDVNVQRLEVLWKNELKTNPNNPSLLKCVITFLKPRLILACFVFAFCLIFGFIGPTCFVRSIIHFAEEPTPLPDGNINYRTGFLFVGALFIVEVARVISYGATWAISYRTGLRVRGAVLGLLYKNLLNVRSMKGKTASEIINIYANDGQRIFDAVTFAPLVLIGPTVLFGGMAYLWYKVGWLSLLGIFVFLFCDALQAVLGITMVRFRALAIKTTEKRMSLMGEIIRCIRVIKMNAWEDLFIDKIELLRKEEQKYLRTAGYAQSFAIAFGTIVPVLAMIVTVLAIVIKGQDFAASDAFSMITVYFVMLFGIRMIPYGARYLSESVVAMRRIQSILQFPSTGEVENMPRNPGIAINLNEASFEYDKIYLEPPTRRKKKDSNEEEVEELQAKESNENSTFNLNNLKLTIKKQELVGICGPVGSGKSSLLTALNGHMDNISGEYKINGSLAFVGKDPCIQTTTIRNNILFGQPLNSSLYNKVLDVTELSEDIERFPAKDFTELGERGTTLSGGQRARIALARALYANKDIYLLDDIFSSLDCVVAEKIFKKAILSMLKYKTVILVTSNPDYLSKCGQVIYMDGGTILEDGSHEELLERSEYYKNFFTTLKVKKDYVDEATKEIISDNDDTKEDKLFHTPEKDGRIIDEEEDYGLQGISCKIYHEYIMAAGGYIVLSILLLAFIINVGTTIFSTFWLTKWMKDSHEHVNITSNGTIFKQYISLAENEHTTYYASIYAISLVFLFFSALIKAMVFVKVSLKASTNLHNKMLHSVLHAVVSFYDSTPVGRILNRFSKDVDEVDVKLPFSSEAFLQNMITCIGFLAVIAWVFPLFILFCIPMMALFAIFFTLFQSGIRSLKRTENLSRSPLYDHITASVEGYATIKCYHQTENFIKKFNQKFDENSGAVLMFQSATRWQAVWLDILVVLITTCVAVFIVWLTGIVNPAEAGMALAFAIQMSGIFQFAVRSQTELESKLTSVERISYYFNSVTQETRSNTRNVPQNWPTKGDIVFENLRMRYRVNMNLALDDVSLHIESNEKIGIVGRTGAGKSSVCNALLQLYPLQNGRITIDNIDISDVDLKRLRSSLSVIPQEPVLFAETIRFNLDPKRNFADSDIWDALDKTNMKTLIGNLPQGLDYMIEENGSNFSSGEKQLLCLARAILRKSKIVILDEPTAFLDEQTDLIVQKCVNSSFQNCTLLLIAHRLGNVLNMDKILYMGDGKIIEFDKTKTLIKDKNSQFRAMLSGTNLVVDTEDDTEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9M9</accession>
    <name>A0A0N5C9M9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9M9"/>
    <dbReference type="WBParaSite" id="SPAL_0001460800.2">
        <property type="protein sequence ID" value="SPAL_0001460800.2"/>
        <property type="gene ID" value="SPAL_0001460800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895576" evidence="3">
        <location>
            <begin position="19"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001460800.2"/>
        </source>
    </evidence>
    <sequence length="738" mass="84381" checksum="385CC93912FD9682" modified="2015-12-09" version="1">MLVKFLPILLFIFKDINSQHDDYQEIRIQENNCPMQVYGTEKKVTLNFNTLKKYDTDKKKHENVNFNEIRIFHLDWDEIKSTSSHTNLLCGLTVYRNNNSEKNFDISYSTGFYKGHKLDDIDFPIYCNIQQCDLGLVFFDRTKNSTILNKVEKIYTVDYAVLMVVKSSDNKMLLGTKTHDKVNIRISICPYINWVHEKGLLQFIPEEYIKDNGYFEVEDGKAHIVVPFYKKNENSDEFICGKLKQPTMPDILVGFKLKEKPKNATIGVDINPLEDKLICQTGDQITKHFHFGYLEKDTNYMSERIMETIEVREIINPKYNFYAGQKIYIYESKDILEAMKNEYDHLRLKDPIIRRRVLCIRNLKKGIKANILPSIGSVDSIKKNERLNIFYRLIQSEDLNRKSPFRCLSKVDGKNKAHMEEFYSRTAKFSIKSEEDPNIVYTSSKDEIVFTNKEIQNYGSYRCKESDAINLFDKNYITMDKVYYLPYEGAEMKFVESHVDDTYQSDIGCNKQYGTFGVIKKITIKFGQNVSDPITIEDFSNSTDTIDIKEGKIIYKPSKNILGVTVECTYTTPAETTFYTTKTFIIGKTQGTETENGTGKSITKEKVVNQVKNNSTPWVIGLAVTVVLFCIIVTVVAYLIVRRIKKRRAEDSLSLSSYSGVSTLSKSSSKGSRSMSGSKGRTNGGSKSSSKSTASKTAKSGKGSITASRSSNVTRNSKSSTSTNRGKNYYKNVKLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA51</accession>
    <name>A0A0N5CA51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CA51"/>
    <dbReference type="WBParaSite" id="SPAL_0001477700.1">
        <property type="protein sequence ID" value="SPAL_0001477700.1"/>
        <property type="gene ID" value="SPAL_0001477700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001477700.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18857" checksum="2EA0609E5EE3C7CA" modified="2015-12-09" version="1">XNESETAHRSSVNSLQYDKNTGRLFSAGSDSIIRIWNTSKPDSSINETTSKRYIQSMEHHCDWVNDIVLCCNGQNLISASSDTTIKVWNAKQGFCMSTLRTHQDYVKALAYAKDVELVASAGFDQAIYLWDVGTLTKLTATNNTVTTSSLNGNKNSIYSLAMSSNANVICSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAC3</accession>
    <name>A0A0N5CAC3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAC3"/>
    <dbReference type="STRING" id="174720.A0A0N5CAC3"/>
    <dbReference type="WBParaSite" id="SPAL_0001484500.1">
        <property type="protein sequence ID" value="SPAL_0001484500.1"/>
        <property type="gene ID" value="SPAL_0001484500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001484500.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9585" checksum="8CBBCFC43BEB1231" modified="2015-12-09" version="1">MKNGSCLTIVRGHRNRWAKMRALKTSRNSGIQIRRETMTADRYCKEEEEMRKKLSVLKPALVNKRGPILLHDNAKPHVSKTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAR0</accession>
    <name>A0A0N5CAR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAR0"/>
    <dbReference type="WBParaSite" id="SPAL_0001497900.1">
        <property type="protein sequence ID" value="SPAL_0001497900.1"/>
        <property type="gene ID" value="SPAL_0001497900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497900.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="39385" checksum="811300909F024CF8" modified="2015-12-09" version="1">MKSEEKGDYNKIEDMIARIKEELRLLIDERKNIFDEETRNNFKSKLNAMKFEKHFDEHDLSNVELMEDCYENIGINYNDRIENIVETIENYFKTLLDNDEHILNTCERKIFLPKEYKILYVYRNGWYNITGNFFTLTSDSLNEPSFSRYFPNSLNYGYLGFTIGHEMFHAFDSDNYKLILEGDNKNKFSVTQMSIDNYEEKSDCFVKQYGMEKESITNMNIDGLETLTENIADNGGIKIAHRAYMKWLQNNDNKDIEVPGFEKFTNEQLFFISVGRSYCEYQSKDNLENQIKRSKYAPGEIRTNVALSNYKPFSDAFNCQVNSKMNPEYKCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBV9</accession>
    <name>A0A0N5CBV9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBV9"/>
    <dbReference type="STRING" id="174720.A0A0N5CBV9"/>
    <dbReference type="WBParaSite" id="SPAL_0001537100.1">
        <property type="protein sequence ID" value="SPAL_0001537100.1"/>
        <property type="gene ID" value="SPAL_0001537100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="559"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001537100.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="98992" checksum="BDF346604F345CD7" modified="2015-12-09" version="1">MKNQDDPEDDLDNRSQNSEEGFNDDPPIDEGRETPKLQETQTNVQDQTIAKLLYQMEMMMKVQIETITSVQKVVKTQADNIQFLCEKLDRKESLKKKNENSPTISHLPAKRNLEENALQDNSKTIIHYVNPNFSNLKKFDGKMSFSKWHKTFQSYCRINRVDESLMKDCLLINVNQRVAQHILEQNENIDYHQLTSLLSKKYDGKCAILEAETEIEKIKRVNLTLENIDQVSNNIENNIRIIYHDQNEDRIMKECKNVIKNISPNNIKLLLRNETTDNWNYYVASIKECIELSKESQRERKSIPGNEGKEKQIICTKCNYRGHTEKECRSRTRWDPTTKTRVNLHIASKRKEEKNQVTSPTILHKEILIDDSIVVNAALDTGSEISILDEELVKTLKLQLSDDTIAFKTIGDGGVGIYVKDPITIRMHDEEFKIKDFVVLKLPEEMKCKALIGLNILSQSNNFINLKEKKIVTIEELMKQDEDKLKVPVYQNFYIEFNNEETEKYFQGKYDFSEQTLNPSLMSGEQDYIQENLQKKFRYYKVPINLLPIANKIIQKYLDNKVIQVEKNPKFVHPIVLIRKQTVQDPKKELKPEEMYRLVSDLRLINSLTIKQYGPSINTVNEFKRIPGGGKILYSLIDLSNAYQQVLIPENMRSKYSFSADGINTYSYRTLPQGATNSAIQFSLVTGNLLIPFKEKGLIIQHIGDFLVITSETKDTSDSELIQKHDELLEQIFKIFTSNNLLFNIHKSKLFRTELRYLAYTLNPSGYTPSLQSVANLIRKIPTTKTELQRFLFGTQYFRQTLPSFALYSERLFSKLSKKKNNLFMDNTDVIHYNKIVDELLSSPTIGFPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCG8</accession>
    <name>A0A0N5CCG8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIIa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCG8"/>
    <dbReference type="STRING" id="174720.A0A0N5CCG8"/>
    <dbReference type="WBParaSite" id="SPAL_0001557700.1">
        <property type="protein sequence ID" value="SPAL_0001557700.1"/>
        <property type="gene ID" value="SPAL_0001557700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000055">
        <property type="entry name" value="Putative microtubule-associated protein futsch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001557700.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25854" checksum="8124E4E138A0B5EE" modified="2015-12-09" version="1">MSEQMSEKYKIPEALRPLLEALARETIRAQPADVISFGKLFFDILSLHQKDSDKSVISDNISYDMFRMDLQQRYKNMTMKENIMRSASPEDIAATKIQAVFRGHQVRMHPEKYGIDNELVRRRSSDKFPTLDFKKDQKRHSIGGYSLEHSQTPEDRAATKIQAEFRGYLARKNVQAMREQNDNAATKIQAHVRGFLTRKRLGKEGLISPSRSHSSLQSHKSEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDE5</accession>
    <name>A0A0N5CDE5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L32, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDE5"/>
    <dbReference type="STRING" id="174720.A0A0N5CDE5"/>
    <dbReference type="WBParaSite" id="SPAL_0001589100.1">
        <property type="protein sequence ID" value="SPAL_0001589100.1"/>
        <property type="gene ID" value="SPAL_0001589100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001589100.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21058" checksum="8F61F7326EA7DD0C" modified="2015-12-09" version="1">MFIQFRRKCEEIVRLGYNILSHNYPPVAPALALSPTVSLPTAASSSDRYDVNKIINDMRILLGVPKYRTSKPKKQTRKFSYTRLLTPEENLITCQFCGSYHTDDTICKNCYSKVREITNMIKEKMMEYNPYKGESQDRGIFVKYKDDKEVKPEVVDGKRVIEIEKPRNSWFIETIKSSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDL3</accession>
    <name>A0A0N5CDL3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDL3"/>
    <dbReference type="STRING" id="174720.A0A0N5CDL3"/>
    <dbReference type="WBParaSite" id="SPAL_0001595700.1">
        <property type="protein sequence ID" value="SPAL_0001595700.1"/>
        <property type="gene ID" value="SPAL_0001595700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733486" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001595700.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45163" checksum="B61C0BD50EC9DC00" modified="2015-12-09" version="1">MKLISVIVLTSFLFILQNASEENILERRKRNIIVKGGPPYPHFPDSIMYYVSDDITQKLIVHPLINLEWRICVNFEKQNFEVNGIGINFYSSNTTDKVILSKSIDQPTRVYLTKKTLQNLRLVRYHIGVALGLTPEITRFDRDKYVKILWENIDKSYMSYFKQSNLNKKRIFNTAFDFGSIMLFDPYFGTKNGKPVYSSKISPYYEQMAGKFEDFSYNDIKILNDLYCNGLCKKDKVLCVNNGYLSSSCKSCTCPLVFSGPTCKNLAIHDNGCGPKKIFFASKKKQYIMGNSFKGNCFWSIYSRKLTSLEIVVEKMSYQPKYEFDEKDGLEIRHLFDKGTTGLILRGNYTNVRVRPISSNVILRYKAPFKYHELKISYREVKKNKLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDM3</accession>
    <name>A0A0N5CDM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDM3"/>
    <dbReference type="WBParaSite" id="SPAL_0001596700.1">
        <property type="protein sequence ID" value="SPAL_0001596700.1"/>
        <property type="gene ID" value="SPAL_0001596700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001596700.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12683" checksum="FEA352CF34D504BD" modified="2015-12-09" version="1">MESTKNNDDNNEVIIHDHVIDVNESHPLLKDDMFSNITMECNKERRSKHKVKTKRRPVKGFSKLPNLAKNAALIIQDKLKVSMVSFNPYILPVKIINTLSVIVKKEFPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDQ7</accession>
    <name>A0A0N5CDQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDQ7"/>
    <dbReference type="STRING" id="174720.A0A0N5CDQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001600000.1">
        <property type="protein sequence ID" value="SPAL_0001600000.1"/>
        <property type="gene ID" value="SPAL_0001600000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001600000.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24852" checksum="A51A95CA1B16212B" modified="2015-12-09" version="1">MVLNYDLNIFIENINKNGDKVLESLKSYNSLLTVVKGFRNGLVYGAKIRAPHALVMTFLFQNGTFLEKLNRVFMLTKQHALNLAKFVFIYKGSRVILEYLFGQNISWQSFISAFLGGYYIFGKNNNVNMQINLYLLSRIMLALSKLAVKQDIIQEPESPIFPWFGAFVWGIVLWLFEVHPELLQKSLFSSMKYLYHDSNKFKNFTTFLWKNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDR0</accession>
    <name>A0A0N5CDR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CDR0"/>
    <dbReference type="WBParaSite" id="SPAL_0001600300.1">
        <property type="protein sequence ID" value="SPAL_0001600300.1"/>
        <property type="gene ID" value="SPAL_0001600300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="260"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001600300.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42676" checksum="F2A6DAA06124C4A6" modified="2015-12-09" version="1">XHQAHSLHMIKDNINTLFIDIDHDNEFVGFAVSWIKGGKPFLLYSNSRVLQGSQKFYSPALRLLLAVSIAAEELESILLYNNIVVYTPSVDIKKMFDSFASFDECISNDTTFVRLMTKLSQVKKKNSKSISDVPHFLIASKDAECETILEPKLIIDEYKNDYMYEVLKNQDRKKWPICLRKFKTVHEDQGLLFLDQRMFIPSTLHSELLSKLHGPHRSLLHMRRTIAMKFIVEGYTRKTAKFLINCKECQTAQKNLNKLISSLPKATFSSERIHIDNMVYGKSKICVMYDSFSRLTKAFFIKSYALKEMIKCVEKWIEEVGTISILVNDNHRPLISSEFDDWLKDHNIYHMRSIPYRSISNGSVERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE98</accession>
    <name>A0A0N5CE98_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE98"/>
    <dbReference type="STRING" id="174720.A0A0N5CE98"/>
    <dbReference type="WBParaSite" id="SPAL_0001618800.1">
        <property type="protein sequence ID" value="SPAL_0001618800.1"/>
        <property type="gene ID" value="SPAL_0001618800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="179"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="805"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="949"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001618800.1"/>
        </source>
    </evidence>
    <sequence length="1077" mass="123450" checksum="041372598D506D9B" modified="2015-12-09" version="1">MDNQTPKERRKVQELLKIEAEIQKKWEDAKVFESDASNEKMEKFMTTFPFPYMNGRLHLGHTFTISKSEFTLGYQRLLGKKTLFPFGFHCTGMPIKACADKLAREMETYGYPPKFPNEEETTPEVEENDAIAEITKDKSKGKKSKAVAKAGTAKFQWQIMQSLGLSDEEIKEFANPIHWLYYFPPKAIHDLKKLGMKIDWRRSFITTDVNPYFDSFVSWQFRKLKESKKIEFGKRYTIFSPKDGQPCMDHDRATGEGVGPQEYTLIKLEIVEKTKYLLEKLNGNNKKIYLVAATLRPETMYGQTNCYLHPDIAYSVFYVNNDESEMFVATKRSARNMCYQDITKEHGVINFVEGLETIYGRDLLGCGLKAPLTKYEKVYALPMLTIKDDKGTGVVTSVPSDSPDDLAALNDLKKKAALREKYGITDDMVFPFEPVPVIQIPSIGDMAAVTMVEKLKIESQNEKDKLEKAKKEVYLKGFYDGIMLVGKYKGMKTADAKKLVREDLIASGDALNYNEPEKKIMSRSGDECIVALCDQWYLNYGDEEWKSMAKKCLAQLETYSDDVRKNFERTIDWLHEYACSRSYGLGTKLPWDPVYLIESLSDSTIYNAFYTVAHMLQGSLDGKELGSLEISADKMTDDVWDYIFCSKPYNPETMPIEEGKLISMRKEFEFWYPTDMRVSGKDLIQNHLTYYLFNHVAIWPDRQDKWPKGIRGNGHLLLNNEKMSKNTGNFLTLYESIEKFSADGTRFSLADAGDGVEDANFVFAMADAAILRLYNFVEFVREIVALRDEGKLRKDVENYSFADAVFDSEMSFLINQTKEAYDKTNFKEALKCGFFEFQSARDRYRELCHGDSCNMRCDLIMKFIEYQCIILSPICSHVTEKVWEIIGKEGFVVNAKWPDVSPSDENIIAQARFLDSVMRDFRLRLKNQLNPKKKPAKPILPPTSATVYIAKTYPSWQGETLRILNELYLSNGNQFPDNKVISQTLGKCENLKKFAKKLMPFVQLVKSNVEEKGISAMSVVCEFDQKQILETNLAYILSSLQLKEIVFKDSTSEGVDKTIAETCCPGSPVIIYEFPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEJ1</accession>
    <name>A0A0N5CEJ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5CEJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0001627900.1">
        <property type="protein sequence ID" value="SPAL_0001627900.1"/>
        <property type="gene ID" value="SPAL_0001627900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001627900.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14716" checksum="4058D2C149284C9D" modified="2015-12-09" version="1">MGTKLSVSLDNALSPNTAPRTDRPPTFDPLYGFPKGRKPREMKVTMEEMDEWNLTPGQRDYCAHLLIPFLKCQRANAPFVGHTCETERHNWDRCEYDDYLMRIKEFERERRLLKRKARKEGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEN6</accession>
    <name>A0A0N5CEN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEN6"/>
    <dbReference type="STRING" id="174720.A0A0N5CEN6"/>
    <dbReference type="WBParaSite" id="SPAL_0001632400.1">
        <property type="protein sequence ID" value="SPAL_0001632400.1"/>
        <property type="gene ID" value="SPAL_0001632400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001632400.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26345" checksum="1BE0B75CC2689674" modified="2015-12-09" version="1">MSNRKKVQKGSIMGAIVLGGNMEDSRVFKGIVINKDVVHPKVKRRIENPRVILLDCNLEYKRGESQTSFELMNEVDLTIVLQHEDAEVKRMCDETIALKPDLILLNIIWLKAGIIALRRLKKTSNNRLGRATGAVIAHDTKNLGEENVGTLCVLFEVKKIGDEYSACINLSKVIISTILLRGPSKDIINEVKRNLLLNPKIVAGARACEMALGSVYMCWKITTYDAHEMQLFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEU4</accession>
    <name>A0A0N5CEU4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEU4"/>
    <dbReference type="STRING" id="174720.A0A0N5CEU4"/>
    <dbReference type="WBParaSite" id="SPAL_0001638100.1">
        <property type="protein sequence ID" value="SPAL_0001638100.1"/>
        <property type="gene ID" value="SPAL_0001638100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001638100.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38525" checksum="B49A0625F1550829" modified="2015-12-09" version="1">MVFILGISGCTCSGKTTLSNILFKKALEKKIKVDKISQDDFYLNKEEVRQIKNKENSDIVFYDYDSVSALDKKKIINEVNLKKQNCDLLIIEGTMLLEIEEIISSLSKIFYITLEKDICGERRKNRKDYDPPDNVGYFDQIVWPSYENNLKIAKNLSNLYGKNFISFVDGKDICLDQINNFCDHLWREIKLDVVRIVIDDEIDINQITKIITSPSCGAISIFIGTTRDNFDGKEVIRLEYECYEEMALKEMKKLCIKGRDKYKTIQNIAIFHRVEHVPVTEASVVIAVSSPHRHECQEATSFLIDQLKVTVPIWKKEIYSDNSGQWKRNCCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF70</accession>
    <name>A0A0N5CF70_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Bms1-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF70"/>
    <dbReference type="STRING" id="174720.A0A0N5CF70"/>
    <dbReference type="WBParaSite" id="SPAL_0001650700.1">
        <property type="protein sequence ID" value="SPAL_0001650700.1"/>
        <property type="gene ID" value="SPAL_0001650700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="75"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001650700.1"/>
        </source>
    </evidence>
    <sequence length="1090" mass="125605" checksum="F023EFE38648CE39" modified="2015-12-09" version="1">MDEILPKKQKAHRSHKVGGKASKAAKKQTKANVGSNPKAFTFKSANRARAGIKRSANISEKKKHIPLIDTTPLEPPPIIVAIVGPSKVGKSTLLKGLVKHYLHITMNNLKGPISIVTGKTRRVTFIEVENDVNSMIDIAKVADLVLLMIDANYGMEVEIFEFINICQTHGMPKIIGILTHLDLIKKTADLRKTKKHLKHRFWTEIYDGAKLFYLSGLKREQYLNAEIKNLARFISVVKFRPIIWRQNHSYILTDRFEDLTNPEEIRKNPKCDRNISLYGYVRGSNMKSENDVHIAGVGDFKIKDICTLPDPCALPDKKKMKRTLNDKERTVYAPFSGLGGIVYDKDAIYVESSLLDKKDSHDKNGLVSQFDELKETIDKKVDKSQMKLLVQSANAIEINKDSEDELSDGYESNESIDEEDIDEEDVDEDDIDEEVMDEEDIDETEEELEPVAKKSKFIEGYEKVVHEDDEDWQKLTLKAKSLWKKGKDNKINWNKFVYNPLKIEEENSSDEDYNENDFSGGLFKILKNEKGKVNTTIEHQEDGYCYTTSCSSTSSAGNFFKNRSWDDDVTRQLIRDCFVTGKWDNEDDAFNVGETFNSETGICEDSDNDDDDESINSDEGTNNPSFVNDKKALHKEKITKKREKLKAQFNAEYDENNEAYNALKEELDVQAKLNKTIFDGMDEPTREKLEGWRAGKYVRMEFEALPCEFVEKFNPSRPYIIGGLLPGEQNLAYLESRIKKHRWYDRILKSRDPLIISCGWRRFQTVAIYTVQDHNMRHRFLKYTPQYMFCHGHFWAPIVPQNTGFLAIQSLDEEKKSFRIAATGVILTNNKTPEVVKKLKIVGYPYEIFKKTAFIKGMFNSKLEVAKFEGASIKTVSGIRGQIKKALSSPEGAFRATFEDMINKADIVFLRSWISVDIPKFYVPITDKLIDNEEKWVGMKTTGRLRFEKGIVLEHDSNTNYKNIERPTFVKKDLIISKDLQKALPYTLKPKMSDAKKDTRPLIVKKHTAIELSHEEEKVDNFIKSVKIAYDEKLKKEKEKNSLRQQKRDKQLQEIEEKKMKKSKQTKKNICRRMSKQEQARVRRAAKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF92</accession>
    <name>A0A0N5CF92_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 2</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF92"/>
    <dbReference type="STRING" id="174720.A0A0N5CF92"/>
    <dbReference type="WBParaSite" id="SPAL_0001653100.2">
        <property type="protein sequence ID" value="SPAL_0001653100.2"/>
        <property type="gene ID" value="SPAL_0001653100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF62">
        <property type="entry name" value="DNA TOPOISOMERASE 2 TOP-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="487"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="13">
        <location>
            <begin position="747"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001653100.2"/>
        </source>
    </evidence>
    <sequence length="1039" mass="118412" checksum="4328B6BDEC14C5FC" modified="2015-12-09" version="1">MSSSESEIQEVVVINKKRSLAKSPKKNGGPFPNSTLSKEDLSVFTNIDNMENNKSAGKITIEQMYQKKSRSEHTLLRQDAYIDSVQYSDKAPMWVYDIENDKLVQREISYVAALYKIYDEILVNVADNKQRDKNMNIIKVNIDKASNTISIYNNGKGIPVAHHGVEKMYVPELNFGTLLTSSNYNDDEKKTTGGSNSYGATDYEMHSTRYSYGTSGKVYKNLFIRTLVNNAIKDREPEIEKASGEDFTKVTFKPDLKKLKMKELDDDIIGLMARRAYDIAGTTPGVRVYLNGKVIPVKSFKEYAEKYVESVVGEDNKKPKIIYEKVNDRWEVALTVSERDFQSVSFVNSIATSKGGRHVDYITEQITANMIDTIKKKAGGVNIEPFQVKRHIWVFVNCLIENPTFDSQTKENMTLQAKSFGSKAEMSEKFYKEALKCGVVEAVLSWIRFKQQEQADKKCSTKKSTKVKDIPKLEDAYEAGTKNSYKCTLILTVGDSAKTLAVSGLSVVGRDYYGVFPLCGKMLNVRDCSMKQINDNQEIGHMIKILGLQYRLKYDTEDERKTLRYGRVMIMADKDQDGSHIKRLLINWIHCNWPALMKNNFVEEFITPIVKASKGNTSLSFFSLPEYMEWRNSTDNWKSYKIKYYKGLGTSTSKEAKEYFSDMDRHRIPFTYSGPECEEAVEMAFSKKKIETRKAWLSNWMREKKARRENGGIEEYLYNNDTRSVSFVEFNNKELIHFSNMDNERSIPCLVDGLKPGQRKVLFTCFRRADTKEVNVSQLAGDVAKMSAYHHGEQSLMMTIINLAQDYVGSNNINLLLPIGQFGTRFQGGKDSASPHCIATRLNPIAKTLFVQDDENVLRFLFEENQRIEAEWYSPIIPMIIVSGAEGIGTAWSTKIPNYNPRDVMANIRRLIRGENMKKMTPWYKGFGGTITQVDEQKYISSGRRVEQLSNSTDKSPALTQDYKECHNEQTAKFIIKMTDQNLKKVLSQVGSLSFKFYGGYKRVPIMDKIYRSPGLDVVISGVLIVLSFGFALFTSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFC0</accession>
    <name>A0A0N5CFC0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFC0"/>
    <dbReference type="STRING" id="174720.A0A0N5CFC0"/>
    <dbReference type="WBParaSite" id="SPAL_0001655600.1">
        <property type="protein sequence ID" value="SPAL_0001655600.1"/>
        <property type="gene ID" value="SPAL_0001655600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="13">
        <location>
            <begin position="56"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001655600.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17944" checksum="643C1AE465E2894F" modified="2015-12-09" version="1">MENLDIDEILNKLPLNVRESARKILEQKKEEKLLRDRVHKHVCNLIEPVKVDDVEKVLNDLDKVTWTNIIEERSISLLCGLPTCCNEIEKPKKQKYIIDFKESVIYGNDAEKLKFCSGVCWKSSDAIKSQLFDQPLWLRNQKIVKNYDLSGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFH3</accession>
    <name>A0A0N5CFH3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFH3"/>
    <dbReference type="STRING" id="174720.A0A0N5CFH3"/>
    <dbReference type="WBParaSite" id="SPAL_0001661000.1">
        <property type="protein sequence ID" value="SPAL_0001661000.1"/>
        <property type="gene ID" value="SPAL_0001661000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001661000.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49969" checksum="A14887A2055489F3" modified="2015-12-09" version="1">MPTIPRIVRFSSQKPIEHELPDSEPISTPAINTILSIPLPRRLSDSEYNIEIHTASSTEKEATEILLKNKANPNATNSTKWTPLMYAAYLGHTSICELLIKKGALLNSQNQKGQTALMLASTCGHDQTVKLLIKEGAEVNKQDCNGQSALYYAVSSSQSSTTEYLLSWGANPNVVDLYGMTPTLEACSIGHEKIITILMKNKGNPMITNKKGENGISLIGDSPSLLSLLKQYGVNVSDKKKIGVTNITINSNSKPSEIDVPRQNQKITVTILEMLKALKLEKYLPNFEKNKIDMTNFFTLTDDEIDEMGIKAFGPKKKLLNIIQRYQQTGIFDIIPDTTTDGGDNQSQTNEELVLLNAQMTSKLHECQRKIQLNEDEIRQQKKIIQDQQAIISRLSASNENLVEKLKMLNYDVSVNFFGLTDQNQKAKLQERILDCLKGFYTDNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFR5</accession>
    <name>A0A0N5CFR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cysteine-rich with EGF-like domain protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFR5"/>
    <dbReference type="STRING" id="174720.A0A0N5CFR5"/>
    <dbReference type="WBParaSite" id="SPAL_0001669900.1">
        <property type="protein sequence ID" value="SPAL_0001669900.1"/>
        <property type="gene ID" value="SPAL_0001669900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001669900.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38310" checksum="80DFCFB7CC6E1220" modified="2015-12-09" version="1">MENVHGDCTACKLLVDTFLVGLEKTKKGNFAGGNTDWEEKKLGTYKKSETRFLEIIEFVCKKDSLDDKDTYSHISNIEFKCHTLLENHEEEIEEWFKNDQDKHSDMMKYFCYDKFKLCCPSGYYSSECKPCPGLLSNGKVCYGRGTCNGDGLRKGTGKCSCDEGYAGPYCNNCASQYFEKIKTDSYIECEKCYEGCAKGCKSSGPKGCTACRTGFEMNEELGCIDIDECLDGEKKCTKANQICKNNIGSYNCLCTDGYILNGKTNECEVDINAHPPSGWYRPDTFLKSIALTSFVAILGFVIWQRSLTLAILALIASILIAYIEYNVDIDSIPDEAKKLFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFT5</accession>
    <name>A0A0N5CFT5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFT5"/>
    <dbReference type="WBParaSite" id="SPAL_0001671800.1">
        <property type="protein sequence ID" value="SPAL_0001671800.1"/>
        <property type="gene ID" value="SPAL_0001671800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895814" evidence="2">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001671800.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32061" checksum="40DF2CCFB10DC8E7" modified="2015-12-09" version="1">MFTRFLLFFFLLILPYINCKIDITVCFTKIWKYGPSEGVKSPQWDNHPANTTVEVFFLSRVNSTHFNKSEGEELRNVVEMYLPIDSYQGMTYPCLSKTLDWPKTKEDEFKLKQILLHSTQKEEFAFSFIQVKYKNIKYEKLPFEGHVLTREDFLLIDTELGIEYVIPATPFMKNGILDGSKIVINTTPQETHSIKIGSLSFNNPLHFLSILSISVAAVCFVLFICMIILLICSCTQRTEKNKKLRMASMTIEREMIIKGMNEINKEGDDTSTGTDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGM1</accession>
    <name>A0A0N5CGM1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGM1"/>
    <dbReference type="WBParaSite" id="SPAL_0001699700.1">
        <property type="protein sequence ID" value="SPAL_0001699700.1"/>
        <property type="gene ID" value="SPAL_0001699700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001699700.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77627" checksum="68B4AE7A517BB5B5" modified="2015-12-09" version="1">MLILIFLLVSQTLTFKVEWDGKKDGTPRTYKLFNLQSVKVFWESQDHNTTQEYLPVPLTISDILLVNNAKIVEANASDYVPDGNIIAFQVHGIKSLYVAVVYDEKNYFNVYHLQTCQIAHCENGLTLIPPTNEIPKIFGPEVNKYDDIIYVKYITEDMNLKLYVFQISGDDFPLVICPYKGWVSIYSGTEFIPYEETNGIMYDQFRHRQIILPAYPRNDDTDVFVCGSIKYKDGSQLTISYKMEVENYYDIKSNEPINDIEAIWKCSESNKISDNYYFLYSKNDKIRNKMKYIKYDSRDNAKFYYNDTMYIYKNNDELKMLKKDGYKAHENKINFTTITPSCKRTLPQLKFKLKLVSPDGTNTFDSKNETKILDVTEDMLNKELNYKCKIFVEEASNHPFLSNYYDDVMEVSLVSKDDDGNTILHDTIMFKDNFDGFKKYECEIRLKDNNFKYKYATENLSFITIPSNLSIKNQSEEWRVKEDVVIQCQRRLSNIGEIDRIKVEVPESFLVEYSNLTSNGIFNIEGDYVRANYDNLIKSKGKKNGNIKSITTICIYKALGGKLLSIFKSGTILQKTIITQKVNKSNQAKKKREKVIIIGLSVGIGILVLAIVIAITTIFVVRCLNKRGRKGKNSSLSISSSFSSYANSSMSGSLLSGSGLSTSTVRKSQSNVSGVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHE8</accession>
    <name>A0A0N5CHE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHE8"/>
    <dbReference type="WBParaSite" id="SPAL_0001726500.1">
        <property type="protein sequence ID" value="SPAL_0001726500.1"/>
        <property type="gene ID" value="SPAL_0001726500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001726500.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35388" checksum="BFC80E9C5356DFE7" modified="2015-12-09" version="1">MIDGLKIVTILEYTTTLCSILCLPVNIVFLIMLYKRHNQPTLASSFFVLCRHLTVADILMMLYSTILFKFPIYGWIPSNFVWELKDWSVLPVLGVQYFGHAQAIGIIGIALNRFTAVYSPIRHRDFWWKKSHINLLLFLQWVLPLFCILPLFFAEFKVVLNSHTGGVLFYASDHSFHRVYFLGMSVLDGGIINAFVSVLYGSIFYHIKMHVTIKKPHEIALRLASSGFLIFLCYLALGIFSLLSALAPPTDPWMYRTIWFIVNDVLCSTNAPILLALNKPIRKEFFKVIGSRNKTTINKKEHLLIEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHY0</accession>
    <name>A0A0N5CHY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001744200.1">
        <property type="protein sequence ID" value="SPAL_0001744200.1"/>
        <property type="gene ID" value="SPAL_0001744200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895962" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001744200.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31988" checksum="551CCCEC7500B4F5" modified="2015-12-09" version="1">MSKILILILATTLFTFTPVCSLSNETRGGFVLYYDNEVGVNWNDTKVSVLGKLSEKVFENFKNIFNITHHNGIYRSFVKPFNDIATSEHGNPGENYLLKLIESSKIDLVSSNTEIKKKAVEKYGKILTNMSKIASTNKYGDFVKEVKKVFDFSSNADGKFKNYQDEILKLKEQLEGNEKLIIKNGDENKRLRNIVIEFLENKFLYVVLDFTENCPIELKFNEAKKEYTAFTTYTNGEIYKKCLKNYYGQLYKLLDKSGVEFEGKRMFEKVKSNFGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2K1</accession>
    <name>A0A0N5B2K1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Centaurin-gamma-1A</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2K1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2K1"/>
    <dbReference type="WBParaSite" id="SPAL_0000030800.1">
        <property type="protein sequence ID" value="SPAL_0000030800.1"/>
        <property type="gene ID" value="SPAL_0000030800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000023">
        <property type="entry name" value="Arf-GAP with ANK repeat and PH domain-containing protein cnt-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="261"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="486"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000030800.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="87791" checksum="0BE6A24C7B213E00" modified="2015-12-09" version="1">MSECPMILVGSLDTISSSSPRVVSEHEARSLAVKIKKCAYYETCATFGLNVENVFKDVFGSPAIVGGTKNNSSSQYNNQESGQENQNNHYAVPHSSQTLTRGSRSSSRNSCISNNLSEKDRDNRRHSQYISSQNYLNTVKESPSINHKILDKGSSATSIPFIPPLPITKPPSMAPPEYNGIGKNNPIIHDSVEGGNTSTPTTSNNLFPHQQHSSNHKMPTPSSTPNTQRKHRRISNIFHRHHDDKQSPAQMLQNLGGGRAIPIKQGLLYKRSTKSLNKEWKKKYVCLYSDGRLCYHQNLKDYMDKGSQGKEVFLGLATVKLSGRPRPPRVTQRASVAVPSTSAPNDELLASLSNPTLDIPSNGTVSPSAGDGTSGGSDGGDQVTSAVGSVSRATGSSIINAISAGSNSVLKKKKGHRRLGSSTKNEEDEDCEFEIICFDQKRWAFCAANAEERDEWVSKIEEQIEKALTENKSEKNEKSSRAHGKKEQIEALHNVPGNDKCADCGTFNPIWASINLGILICIECSGIHRNLGTHISKVRSLELDDWPIEYLAVMRAIGNTFSNKIWEHNAPKDKKPQPDSTRDVKETWIRNKYEQKRFLPAIPVDRTLGRQLFDSIIAKDLYNVLLVLSRCSDKEVNGLYTDYDKRAPIHLACAVGSVEILQLLLWRNANFNLLDANGHSALWYAKNNGHKECVDVLLHNGLEDGYGCNDAMKKTTSPTSIDQMIIGSLGNRDFITTTKDDPTISLRGVSISRPTIPKYHIDGSLDHKVNYNFNEEDEVNSEIQYRKVYKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2U5</accession>
    <name>A0A0N5B2U5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2U5"/>
    <dbReference type="STRING" id="174720.A0A0N5B2U5"/>
    <dbReference type="WBParaSite" id="SPAL_0000039800.1">
        <property type="protein sequence ID" value="SPAL_0000039800.1"/>
        <property type="gene ID" value="SPAL_0000039800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000039800.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38508" checksum="D7DE5148A51CCD3A" modified="2015-12-09" version="1">MFISKENFYALISCKVLFFIHYYITSLVNKNVPEPYMDEIFHMDQNRRYCNGDFSWNDKITTPPAMYLLTYKFFCYNERFFNSFLYPLTFLVLLYFRRYYFKTIESILESHLNVLCVMVLPVFFQSTSLYYTDQLSLISVFLAFNSNPYLAAFFFGVAVLTRQTNIVLCLLYLGILFVKTIDTKNYISSFFVFLKKSFLQIVLILLCISFVVFYNNGKIVLGDHSAHTPVLHFPQMFYFMAFCCVSTLPYFTLSIKKNLRFLYKNIVLSIILLFIFNILIYKFTYAHPYLLADNRHFTFYIWRKLLNFHTYSKYIISPLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3S0</accession>
    <name>A0A0N5B3S0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosolic protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3S0"/>
    <dbReference type="WBParaSite" id="SPAL_0000072300.1">
        <property type="protein sequence ID" value="SPAL_0000072300.1"/>
        <property type="gene ID" value="SPAL_0000072300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000072300.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13071" checksum="E5EC7450B666A165" modified="2015-12-09" version="1">MELKHNNLFLNNIQDNDINAEQRLSSFMRARKRSIIGNGFVMEKKDNDEVTLYIVDRKNSESSSVTTKVPYAPLHKLSAPIEAKEHFQLLKDLMNHGKNLVKESGESNENIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B434</accession>
    <name>A0A0N5B434_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B434"/>
    <dbReference type="WBParaSite" id="SPAL_0000083600.1">
        <property type="protein sequence ID" value="SPAL_0000083600.1"/>
        <property type="gene ID" value="SPAL_0000083600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000083600.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15523" checksum="198C8D8409DE038D" modified="2015-12-09" version="1">MEYEMEKDTKYIFLLGIGILCGWMIVIIICASPQLFRNYIFKYLCCCFRNREKNGNQEKIKAAQERVRSASKSFLSNQLASFPSTILLQQVMGTTSGILRNTLNEKDTEEIEEKTQTKMNLDLESVLCEENFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4S5</accession>
    <name>A0A0N5B4S5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dual specificity Yak1-related kinase mbk-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Minibrain Kinase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Possible role in the function of olfactory neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4S5"/>
    <dbReference type="STRING" id="174720.A0A0N5B4S5"/>
    <dbReference type="WBParaSite" id="SPAL_0000107400.1">
        <property type="protein sequence ID" value="SPAL_0000107400.1"/>
        <property type="gene ID" value="SPAL_0000107400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="417"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="336"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="740"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="756"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000107400.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="105903" checksum="35436935ED6C5FC6" modified="2015-12-09" version="1">MISNSHSNVYHISQNIPSDNNSSNNIPNTMDPFMAVDAPQISTNTNPEISFNNRIYRPNPTVNQSNQQPAQIRNINSKNFEVTGSATSTNFNNPQSLSNNLMTTTHQQPQNNLYYINNMQIPLQKKGFSDSSIYEQPFDNNNQLTGQSSLQQGNQNEGNLYKSTFRDPKDSPLQKLTIDLIRTYKNINETYYAKRNKRKQEKQQMQQQNAANKSQGNSCGIQSIQAMNVKNNDQTIMTSDKKSSNPLHQHHSVPRQNTESSYDMLSNMSNQNSNVQPGWVVAPSIILSTSTNKISNSANNGINNNINNNHSMIPNVSNAISTQSQKVALNNPRPLEQQNQIPQSTHVSLSSTVTNDNKQLSNKEYKNRTTSKHASSHSITRNGHGDKNKDIDNMLCGYDDENHDYIIKIGEVFNYRYRIDNHIGKGSFGQVARAFDMIANEDVAIKIIKNKKPFLDQAWIEIKLLELMNSHNSNGKYYVVKLKNHFMWRNHLCLVFELLSYNLYDLLRNTAFRGVSLNLTRKFGHQLASTLLFLSSPELNIIHCDLKPENILLCNPKRSTIKIIDFGSSCTTDGRIYQYIQSRFYRSPEILLGISYGTQIDMWSLGCILVEMHTGEPLFPGHSEYDQVMKIVEVIGMPPKEMLDIAPKTKRYFEKDEHGNYKRKLSKSRVYKPPGSRKLSDVLGVNIGGPYGRRLGEPGHTVDDYKKFCDLVSKMLQFDPNVRISPYYAIRHPFLRKSDDSISSNQMSSQQQQQSYASTVNNSSSNPLAASQCQQLKQQDQHNNSIYQNSSPTTIQEQQSNQISGSQEFINFDNSNDFATPYNKHVYANFSEFTNFNDSQNNFSFTLNEMPYNISTTKYNSSMIKKDTSNNLENKFYGKCNMDGLSINEQYQNVYDNKCSSTNNEMEGLNDDNINESNSYQYICNFRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Y1</accession>
    <name>A0A0N5B5Y1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Y1"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0000147200.1">
        <property type="protein sequence ID" value="SPAL_0000147200.1"/>
        <property type="gene ID" value="SPAL_0000147200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="360"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000147200.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="84251" checksum="FD7DE117B8B11427" modified="2015-12-09" version="1">MNCHLPICKVYKKYPFYYHSEGNHRGDLLDTWVNSSKLVCANSLYRKRRGRRWTWESPYALSTNKDVLDRIEISNHRAEIDFFFISDKRLLRNCEVWSKTQFLNTSDHRPIYIELKDDWLSTQNSYKYKKNAFSFNRKKLDVDKYRGTIQYIDWSYKSCDIDKDYETLCKKLTESYSKCLQLEPKKPSLFSENVLSLFKKKSLLKSRHITRSVVVELNILNKLIRQNIKKDLILRREEIIKSAVLANTSTRRAYIKTIMKKKVISQIYDNKGSVLCSPKDIRNRVAEFYKDLYSERSTNYVIPEIFVNNDSVEPFIRSELEFALWKMKPGKASGVDGIMDYHIKPVQDILIPHLLVRLNKYLDEAKHPSAFKKSKLVQLFKSGDVKCLGNYRPISLLSNLYKLYSLMIFKRLEKRFDEIIDTSQGGFVRNSSCCDLILALQLELERCREFKEIPLYMCFIDFKKAFDLLCRKSLFHILNFYNFPAQYIKVLADVYSNSSLLIEIYGKTEEVEQNSGVRQGDVLSPKLFILCLQYCISLIDEDASNKGISWLGKKIWYLAYADDIVLLSRSICDLQDLLNMIVQVTSDIGLEVNVKKTKYMCFDNNLIDDESSVKLKIDGKEIEKVSQFKYLGKIISINEKIYKNTLPKDDNSWNSFLSERIRGGWISFHKHKRLLLDHSIALEKRINLYVQLVRPSMLYSCQCWNLLKTQYLQNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6G6</accession>
    <name>A0A0N5B6G6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6G6"/>
    <dbReference type="WBParaSite" id="SPAL_0000165500.1">
        <property type="protein sequence ID" value="SPAL_0000165500.1"/>
        <property type="gene ID" value="SPAL_0000165500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000165500.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40083" checksum="67C5F525A3680787" modified="2015-12-09" version="1">MQYIFYQVKLLFIISIFSFVFLQNIECQDKFIKRKPRILYKSTSDDSLLLEESSSDNKEIENISVNLDESEETIEPFIFTTSIPSVSPQPPGIALTIEDEFQTTTLDSLIANSMTTYSIPSSTTKDDFSLEDDESVEKDKTNNIETTSHSIIESSSSHNADLKKSEGVNSFDNSELNNQYVFSVPEEKIVLTTESSKLIENNELNNLDDKDFILIDSKTPTMSPVTVTDDFTSTTETTSINTTSMSSDIPFNTSDKFVINEYNTIVNEGNYTKKVKKSCPEIEICNPGCGISIDSDGCQRCTCLWIPKFCMETAECNGPEYICEYGKCLCNNNYTQDMERSGICIPKPDNLKQNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7A3</accession>
    <name>A0A0N5B7A3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat protein soc-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7A3"/>
    <dbReference type="STRING" id="174720.A0A0N5B7A3"/>
    <dbReference type="WBParaSite" id="SPAL_0000193000.1">
        <property type="protein sequence ID" value="SPAL_0000193000.1"/>
        <property type="gene ID" value="SPAL_0000193000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000281">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="380"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000193000.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="65207" checksum="8AE15CBDA71556CD" modified="2015-12-09" version="1">MDDEETANNEFEFRPSSSKTSQQTSNGGHKEVKHAKTSSIANRSKSPSAFIEKLSNFARGKYRGSLNEKNSSANTLENKLRKDIIKEIQKCKESGSTRLDFNSASIESIPPVIGDLYGQISELFLYKNKLSTLPAEIGHLTNLKILGLSENNLTSLPDTLSQLQKLETLDLRHNKFSEHIPAVIYKIPSLEKLWLRYNHIKNVSKDIKNLINVRMIDLRNNNISELPSEIGCLSSMTICLLSSNHIKYLPEEIGNCSKLSQLDLQQNELRQLPMSIGNLNLLTRLAIRYNQLIDLPESLKNCTKLEEFIVENNKLHSLPDGLLASLPLLKTINVSRNMLTAFPQGGPNQFEAAVSISFEHNQISKIPFGMFSKATGLTKLNLKDNELSSLPLDFGTWSSLTELNISNNNLSTFPEDIDKLVNLEVLVISTNALKRLPPQIGNLRKLRELDVEENELDSIPTELGYLTNLTKLWLQSNKLTSLPATIGNLQNLTEFRVGENMLTFIPKEIGHMGKLKSLYLNDNSYLHNLPFELALCSSLEIMSIERCPLSAIPHDIVEGGPSLVIQYLKTQGPYRAAMYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S3</accession>
    <name>A0A0N5B7S3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7S3"/>
    <dbReference type="WBParaSite" id="SPAL_0000209800.1">
        <property type="protein sequence ID" value="SPAL_0000209800.1"/>
        <property type="gene ID" value="SPAL_0000209800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894088" evidence="2">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209800.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12701" checksum="756F3BD3096F1313" modified="2015-12-09" version="1">MESIKLVIVFILLFNILLTKSFESKNNLVSNNIKSVDNLQQPAILNDEEDTNSIEKRQSRPKKSKAKKRRNKRRRIQQVKNALTQLQSQIASIATRLDTLTTTVRPNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B843</accession>
    <name>A0A0N5B843_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B843"/>
    <dbReference type="STRING" id="174720.A0A0N5B843"/>
    <dbReference type="WBParaSite" id="SPAL_0000221600.1">
        <property type="protein sequence ID" value="SPAL_0000221600.1"/>
        <property type="gene ID" value="SPAL_0000221600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000221600.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30090" checksum="26781F8E967EABF0" modified="2015-12-09" version="1">MVNSSKLFQIKSCKKNCIQYFNYFLVIDFEATCEINSGSDYYHEIIEFPCILVDGKSKQIVSTFHSYVKPRKNPNITAFCTELTGISQNIIDEAPPLDKVWRMFLNWLQENNVDYEKVSTEFVVITDGDADIGRFLIPNLHDLNCYIPKSFYYYVDLRCSMLKILPKVSYLQIHKMSLKAILTKFSLSFEGKEHSGMDDARNILALLKVCIQNNVDILPNSFVEIKKEYDKIKMEEYKYYQCALLKKDICFTIFGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8A7</accession>
    <name>A0A0N5B8A7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8A7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8A7"/>
    <dbReference type="WBParaSite" id="SPAL_0000228000.1">
        <property type="protein sequence ID" value="SPAL_0000228000.1"/>
        <property type="gene ID" value="SPAL_0000228000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000004">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="702"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000228000.1"/>
        </source>
    </evidence>
    <sequence length="939" mass="105607" checksum="B513BC13A29EFDD9" modified="2015-12-09" version="1">MPAVKGDGMRGLAVFISDIRNCKSKEAELKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGYMEAVNLLSSNKYTEKQIGYLFISVMINLQSELMKLIIQSIKNDVGSRNPVHVNLALQCISNVGARDMAESFSVDLAKLLVSGETIDFVKQSAALCLLKLYRTNSDVVPPNEYASRIVHLLNDSHLGVVTSACSLIDALSRKYPDDYKGCVSLAISRLSRIITSTYTDLQDYTYYFVPAPWLCVKLLRLLQNYPPPEDPTNKTKLIECLDGILNKAQDAPKSKKVQHSNAKNAVLFEAISLIIHLDNEPHLLVRACNQLGTFLAHRETNLRYLALESMCLLATSEFSHEAVKKHQSTIIQALKTERDVSVRQRAVDLLYAMCDKSNNCEIVGEMLSYLENADYSIREEMVLKIAILAEKYASDYTWYVDVILKLITIAGDYVSEDVWYRVIQIITNREDVQGYAAKTCFEALQRPACHENLVKVGGYILGEFGNLIAGDARSGPLVQFQLLHSKYHYCSITTRSLLLTSYVKFCNLFPEIKPEIQKVFQNDHNLRNPDAELQQRATEYLKLSIVASTDVLATVLEEMPPYPEKESNLLGKLKKCKPQLEEMEAAVSEKKSRPSAIMSSTSFTPTPDHAVNQNSGNIVDISQDAPSSTGVNVNNELMNVLGSSLTNDVQLESDNRDECIKFVLKNNGVLYEDNIIQVGVKLETKSNLARLGMFYGNKTSQDFSNFSSSITSTKVLEDQLMVQEKPVDSTIAAGTQVQQLINFVCLNDFSLQPVININFTYTQVDGSLGQFSKKLSLPIFINKFSEPTDMTSEQFFARWKQLNQPNQESQKIFVAKYPMEKASIEQKLSSFGCKILVNVDPNPDNFVAASIIETQNFKAGTLIRLEPNKQTKRYRLTVRSSRQTVGQVICEILSEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8B3</accession>
    <name>A0A0N5B8B3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8B3"/>
    <dbReference type="WBParaSite" id="SPAL_0000228600.1">
        <property type="protein sequence ID" value="SPAL_0000228600.1"/>
        <property type="gene ID" value="SPAL_0000228600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="3">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000228600.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="65922" checksum="06C45D5439AFFC53" modified="2015-12-09" version="1">MDYLLNEYLFKYLPINFEESTKKYITEKAVNLVRLADWACKAQDYRKLYDNHASFLLAEGVFVVLSILTLVHAIRHGGRYIYTWIGIFIFSISSEVFRINYGSEWDYVFHAQSLLTLFGMRIPLHVAFGVMPTFVYSSYILAGRLKLVFPLEAVAAGLIHTLLYLPYSIVGTKLLWFQWHEWHPITNEKNSFNVPVAEYFIQSFSVISFLFILNLLRRIFLSSTFDWRLFVREFGIVLSAGLTAFGFTISTFYHSVYYLHFTYNISYFTIVSVYFAVLFTVIYSCDRTNSNGLSKIGNPFWFDEISASIIFIGFIFISLALVGDPFNTVSEGLHQPIGSCKEFGLFKGVKYQKFVCPINMEIKYFDFHCLPGQNPPQQQENNVPLEWYAICGTKYDNKNEFVFSVISIIVVSTIILYQFCALSGETEYDEFLIIHKFSPKPLRQTERQPSPVVSAESSFVKETKIASTRQSRCTPSYESQYLSRKKLQQADDDVTPKKAPGTVSMEKSRSRSRGLPISANRGVTRTITHSRSLKVTKNTVSNGTTSSISKSASSNASSPIGIGVKSLRSRHSNSRTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Q0</accession>
    <name>A0A0N5B8Q0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein HIRA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8Q0"/>
    <dbReference type="STRING" id="174720.A0A0N5B8Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0000242300.1">
        <property type="protein sequence ID" value="SPAL_0000242300.1"/>
        <property type="gene ID" value="SPAL_0000242300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="HIR1-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="13">
        <location>
            <begin position="10"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
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    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
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    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="12">
        <location>
            <begin position="648"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00007306"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07569"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000242300.1"/>
        </source>
    </evidence>
    <sequence length="873" mass="98363" checksum="A355DA90B089F8A5" modified="2015-12-09" version="1">MLRIHTCSWISYKNNQIYGIDIHPSGKKFAICLQVDGGKGNLEMWSMNSIINDTIPKSTSPLFNVAFRSGLNSVRWSKYDHGKYLAVSTEDGIILIIEYLGRCRENKSSSAEDEEDIKELYKTKYELHGHSLSANNAEWSNDGRFLASCGMDGKIIIWNVKKLPEKVVILNEASGGHTDNVNGISWDPIGNFLASQSNDKTLKVWSVDDWKVKTTISKPFEGACNSTMFKRMDWSPDGTILIAPAAMNNKTPATQVILRKNWDYKKDIIGLRQNSTVVKFMPSLIKVKSENDEISTVMVCAIGSRDRSFSLWMFPRYERPLCLIRNLFNDTIHDFSWHNNIVGACSSDGSVQFISLKESEFIKFCGIEELKSRCQFIHKQIPVQFRRDDDMLNDSITEDSCLLYRVPKTIPVKTTSDVLPPPPSVAEKETPKDSDKIEKEKSAETVKQPKLIVRSKNNATVKITSTQIIKEPEEDPKSHHIAAAQPSMISLERLIDEQQFVKPALTMEEFNALLKTKILQESEEDLLDVSFESSMETSTIERAAVPTSKTPKGKLFFTIPEYKKLLKYITENKATIVDCITANNACQLMPGVNITRVTAKLGRVIVWETVITSKIGVIKFNDQYTVLVSYDKTVTILDSKTGRQLIQFILKEMTCIAFLKNHWLSLVSEKGKLYVWNLQIFRNSITISLKAIMQTEKELINVLISPNGIPIIHCENNRIYSYSTITNSLISISNTSDVITRHALAKICGDLDSHSTGVISSLFDSSKLYSNLTLPDDITQLSIERSLESLLTAAKALSDFSDFKKYLHLYAQSLINNGHTEKLEGLIKEIESNKSLICGHDSNEVIEELQPYKEKNRSCSNGASKGVDLMETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S3</accession>
    <name>A0A0N5B8S3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S3"/>
    <dbReference type="STRING" id="174720.A0A0N5B8S3"/>
    <dbReference type="WBParaSite" id="SPAL_0000244600.1">
        <property type="protein sequence ID" value="SPAL_0000244600.1"/>
        <property type="gene ID" value="SPAL_0000244600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090533">
        <property type="term" value="C:cation-transporting ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
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    </dbReference>
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        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 20" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 20" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244600.1"/>
        </source>
    </evidence>
    <sequence length="997" mass="111142" checksum="35B375F9D1F1E37C" modified="2015-12-09" version="1">MKKRRSKDLEELKQEVKMDEHQIPIEDLVKRYDTSLDVGLTSTVAGKYLARDGPNTLSPPKKTPEWVKFCRNLFGGFALLLWIGAFLCFLTFTVDYMTVTNPTNDNLYLGIVLMAVVIITGCFQYYQESKSCKIMESFKSMIPAHALVLRDGEKIKIPVDQLVVGDIVEVKGGDRIPADMRIISSFGLKVDNSSLTGESEPQSRSPICTSENPLETKNIAFFSTNAVEGTAKGIVIYTGDRTVMGRIAHLASGIDTGKTPIAREIEHFIHIITSVAVFLGVTFFVIAILLGYHWLTAVVFLIGIIISNIPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSAICSDKTGTLTQNRMTVSHLWYDKTIHACDTTEDQSNTQNDINKGDTYDALITIATLCNRAEFKPNQNDVPIIRRQCTGDASEVGLLKYAQLNLGDVMEFRSRYKKVAEIPFNSTNKFQVSIHDQPDGYLLVMKGAPERILARCSTALIDGEVLELDDKLRSTFEKAYIDLGGMGERVLGFCDLKLNATEYPKGFSFNPDELNFPLKNLRFVGLMSMIDPPRAAVPDAVYKCKSAGIKVAIVSGDHPSTAKAIAKSVGIISNGSETVEDIALRRGVSVDEVNPRDAIAIVIHGSDLRDMSDEKLREIIRHHTEIVFARTSPQQKLKIVEAFQHEGYIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFSSIVVGVEEGRLIFDNLKKSIAYTLTSNLPEITPFLAYIIFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRAPRDHIRDKLVNERLISLAYGQIGIIQASAGFFTYFWIMADNGFLPWDLYQLRSQWDSRAINNLQDSYGQEWSYANRKVLEYTCQTAYFVSIVIVQWADLIISKTRRNSIVHQGMSNWYLNFGLVFETFIAAFLCYCPGTDKGLRMYGLRFSWWFPALPFSILIFIYDEFRKFCIRKWPGCWIEKESYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA13</accession>
    <name>A0A0N5BA13_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA13"/>
    <dbReference type="WBParaSite" id="SPAL_0000288200.1">
        <property type="protein sequence ID" value="SPAL_0000288200.1"/>
        <property type="gene ID" value="SPAL_0000288200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000288200.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36827" checksum="E9C052A90F8BFDB5" modified="2015-12-09" version="1">MSMRSDNSFYCFICNKIFTSDERRYHHFEKHINYNRFKCLECDSQFSTYDDLECHQECFQHFDFKKTTNLGIRKLITSLMELSLKIEASSDMDSVEFSVTVKSEKSITSDSESAISNDSEENTIDNGKAEDESLISNIKTEVVNVTTVEKDNDPNHENSNDSDRKSASNNIFNGNENLHKPVKMKYSEYLCLRSLDDKIFIEKEKIIDECLQCNRTFLGGKRKIQHVFKDHLMLNEFNVLECMYCLNQKGTSKKFFNISSVQEHYKSIHKFSNSGCPNNLAWNYNEEEQYIHVNGSDDLLLQYETQFDKCFVKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA62</accession>
    <name>A0A0N5BA62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA62"/>
    <dbReference type="WBParaSite" id="SPAL_0000293100.1">
        <property type="protein sequence ID" value="SPAL_0000293100.1"/>
        <property type="gene ID" value="SPAL_0000293100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000293100.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="9020" checksum="87580C6723EB3B60" modified="2015-12-09" version="1">MVLVKIVMYNFTEIVVVHIKSIYIYILFSTLYNYKFKHYVYITVDNVFKIFLAFLFLYSYLILEETFYDLIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA64</accession>
    <name>A0A0N5BA64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA64"/>
    <dbReference type="WBParaSite" id="SPAL_0000293300.1">
        <property type="protein sequence ID" value="SPAL_0000293300.1"/>
        <property type="gene ID" value="SPAL_0000293300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893988" evidence="1">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000293300.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30277" checksum="598BFCD882B87E10" modified="2015-12-09" version="1">MLRQLLLYLLGYSVIVESKKCYSTCNGRSPIYCKSKLNDDNSVSVSGYYNLSKLGMIKMSCSFTSKSHAPDIMWQYRKSRNEKWSDFACDEEIFKHTCKNETANDNQSYGECHIQQNTIKNSGYYKCVEEKNDEGISSEEFFIQIIGVESISVLSRTLRLNKIGQIMMKVCSNPKPNILWYGEDQIVQIGQSTDRYSAMPLSNAIENINIKSNTSTKYEKDCWISTLIIRNVTIADKFIKTFIITENLITEEHVTTTDFPTNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAY8</accession>
    <name>A0A0N5BAY8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyrotropin-releasing hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thyroliberin receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAY8"/>
    <dbReference type="STRING" id="174720.A0A0N5BAY8"/>
    <dbReference type="WBParaSite" id="SPAL_0000320200.1">
        <property type="protein sequence ID" value="SPAL_0000320200.1"/>
        <property type="gene ID" value="SPAL_0000320200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004997">
        <property type="term" value="F:thyrotropin-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002120">
        <property type="entry name" value="TRH_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061:SF3">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000320200.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55327" checksum="F2C99500423B6790" modified="2015-12-09" version="1">MDSSVNPTYSPEYINFSNDENLMGEESYENEESLLDRPLIRNFLIIAYILVFLFCVLGNILILTVIITKKSMRTITNFLLGNLAVADLLVGIFCVVQTGFHFLHSGNSQWIFGKTMCHCYLYLVNMIPNLSAGILVLLSVERFIAVARPMLVHDIMTSRVLVMSTAIVWTFCVIMNLPYLIAVQYISHEDPETGIQMAICTRKHFMLFDINILKVVSILNLVVWYIIPLLILLIIYISIGHILIKSSIKHNKNNHLYKDVRVTINSPNGIVVHKNNLNTPLLGRSSDKLAPNCAASDKRKLSMRNNGSESFDTRRRVIKLVALLVVSFAVLNMPRYIYLTWSVFRDVNSPRCLDCLLTLLHPITFLLMFVNSAINPILYAFLSQRFREAISDTLTCYNEREEKKKKVLESLRCTRLNVNDNNLSASYGGLPSMNTEKESSNINVGRKSISISFNPNININQNSIMSFKIPSTGYFETRKESLPTTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB00</accession>
    <name>A0A0N5BB00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unspecified product</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB00"/>
    <dbReference type="WBParaSite" id="SPAL_0000321400.1">
        <property type="protein sequence ID" value="SPAL_0000321400.1"/>
        <property type="gene ID" value="SPAL_0000321400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000321400.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21567" checksum="E58A8D055388A32C" modified="2015-12-09" version="1">MSLVILYLECFCITALTIIILILLLKFTIIIYSKTIRESEPLDEEKKSNDIYSEKPRFSNYDGSSSPICSVYLEDHLSMIGDDETIKEITKTKCNYLAFDSFMEGIKITEASNNTQHMEYVKRLENQLNILNNDFERALTRDSEHRKRLHSYNFHSQYLLPLDTSMRCHSDSEIFDVSRLEQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBT0</accession>
    <name>A0A0N5BBT0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BBT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000348700.1">
        <property type="protein sequence ID" value="SPAL_0000348700.1"/>
        <property type="gene ID" value="SPAL_0000348700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000348700.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23877" checksum="1BC80869D38B07F3" modified="2015-12-09" version="1">MYPKAFLCSKALLNPLSSPYPSHFVSKLFFTSSIWEKFCTNTNMVSTTAESPIQCPVPVKRPCVDIDKEYAMKDDNNDVIRYVLAHPDALEPKYGSPFSAGADLYAVEETVVPAKGKALVSTGLKVQIPVGYYGRVAPRSGLATKNFVDVGAGVVDSDYRGVIHVLLFNFGEEDFKVNKHDRIAQFVMEKIGHLRYEKVEDINETARGEGGFGSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBV4</accession>
    <name>A0A0N5BBV4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBV4"/>
    <dbReference type="WBParaSite" id="SPAL_0000350550.1">
        <property type="protein sequence ID" value="SPAL_0000350550.1"/>
        <property type="gene ID" value="SPAL_0000350550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000350550.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9830" checksum="4E72370BE6EC20BF" modified="2015-12-09" version="1">MKLPFDIFLFIAKEQYAKSWTLFPLFKTICFEIRTCVYHLIPFTHTFRVIQLMTCDSLLTISSPDEEVEEYFFNRSVTCMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBY6</accession>
    <name>A0A0N5BBY6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBY6"/>
    <dbReference type="STRING" id="174720.A0A0N5BBY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000353600.1">
        <property type="protein sequence ID" value="SPAL_0000353600.1"/>
        <property type="gene ID" value="SPAL_0000353600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000353600.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="85161" checksum="49DFCA0A779F4906" modified="2015-12-09" version="1">MSDTLEVFCRLKPCPQEDSCVQAIDDKYVKIVQPRGYDRRGNTPSEAVYKFTEVFDESCGQRDVFNRASLDLIRGALNGVDGLLFTYGTTGSGKTHTITGEPRNAGILPRAVDVVFNSLPNPTERCVFYPTSLNRFGIRSETEAAYARRELQIPDIRSPVREFESLSIKNVPMSMASAVFVSYVEIYNEYCYDLFDESITASGNRLNKTKEIRAGPRDAAYVEGLVEIEVTSTDEVMWHYEKAQERRRIAETKLNSQSSRSHSIFQIKIVMAPFQDDSYYPDTDPNKIIISQMVLVDLAGSERANRTGNMGERLVEASKINNSLMCLRQCFERYRANQRNPKQPNVVPYRDSKITHLFKKYFLGGGNIRMIICVDPRSENYGENLNVFSFAELSQDIKIELTDVPDIPSGNSLPFPRRDILNWYRFIEKNVNMDPLKLDLFPPPPKRICLDDSNDTNISRIEENLSYYKNRMTRKAQLMDVFADRRRQFGNDLKTVLCERDLSKIRVQNLEQENSELNHRLEVLHKQVLHMNRENAALKRRLFEYEEVDEKRYLAEMELRKKNAMIEKDLERKNRDFRVVRQICEDISISGETGPSVAALASKFDTGSGGQKVPRTPAQQKTTTFAPEVIPTSKQGRRNGYVNPKFHRRSRSAAGRILDHQPVNRVPTGNILQPQLPKLGVKTTFAPSPRDLKRSDAYILTHQEVDNKGNISTNIVKGECIPTSGGGRYVEFTDIENLQHSSPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC03</accession>
    <name>A0A0N5BC03_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC03"/>
    <dbReference type="STRING" id="174720.A0A0N5BC03"/>
    <dbReference type="WBParaSite" id="SPAL_0000355300.1">
        <property type="protein sequence ID" value="SPAL_0000355300.1"/>
        <property type="gene ID" value="SPAL_0000355300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000355300.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54025" checksum="A62D52DE9B25C885" modified="2015-12-09" version="1">MSETNEMKEDIEKVNEENNNNEEDEEIEVDNEQIISEDELEPSPRRKAISSGRNIQELALGNENIQKVLKLSPITTNNQEIYYLYSEKNIDECKQLIEETLKSSNSCNEYAMQVSGAFNLQDLNIVKSLNCYESAFKLNNQNIKYLMDMGRINYLVGNHGQALVYFTKILQINPKNWKAYCWKALSIFYLKRKTPEACNNAIETLLGCSSASKNAEILSLIAFFCREKGDLFSASEALKKASEIDNTNIELLKELGYDYIKLGSEELSFAAFGKALTSDKNHIPSLIGAAYIIQNNGDYDVALTKYRHATSICNYSGILWNNIGMCFYGKGKYIAAISCLKKADYLIPQNWEILFNMGLAYNGLAQYASAYQYISAALNLQPKKAFIFEALAVVLSNLEDYDNARKAFKRALSLDKDKTIGIYLNFAVFEYKRGNVEDSKTLLNEFYQHIEKGSKVDLESSYTAQRLRRLIDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC66</accession>
    <name>A0A0N5BC66_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC66"/>
    <dbReference type="STRING" id="174720.A0A0N5BC66"/>
    <dbReference type="WBParaSite" id="SPAL_0000361400.1">
        <property type="protein sequence ID" value="SPAL_0000361400.1"/>
        <property type="gene ID" value="SPAL_0000361400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000361400.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33248" checksum="F14FD56ACEC40424" modified="2015-12-09" version="1">MSPQSDSLKGKNITIIDVWRHNLFEEGAKICRIIKDYNYVGMDTEFPGVVATPVGPFKKKEDFNYQQVSCNVNMLKLIQVGLTFMNYKGELPPGNPVFQFNFVFDLQDDMYSTESIGLLNSCGINFSKHKVNGISMHEFGELLTTCGLLTDRNIKWLTFSSGYDFGYLIRAVLTRHLPSDEKEFFKLLRSLFPTIIDIKCLLMQPGPSSVNLRGGLQEIASMLHIERYGLQHQAGSDSLLTGNAYFALKSKFFNDNWEEIFKTINGELYGLGDTLSNDNSGVESYRSTSENGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD96</accession>
    <name>A0A0N5BD96_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD96"/>
    <dbReference type="STRING" id="174720.A0A0N5BD96"/>
    <dbReference type="WBParaSite" id="SPAL_0000398500.1">
        <property type="protein sequence ID" value="SPAL_0000398500.1"/>
        <property type="gene ID" value="SPAL_0000398500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894106" evidence="2">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000398500.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="26295" checksum="D3924879EA50A766" modified="2015-12-09" version="1">MLFAILMVAFMVALLSVELYSKPVPDNKQPAKSNGKKEEQKPPADSKGQGGNNPPPNGPGGKNPPPPNGPGGKNPPPPNGPGGKNPPCDDDSSSESSESHEHEGPGHRHGDKHGKDNKCTTTTVTTTIKTTTKPTTSTTTSTTTSTITTTTESIVTSTEDPTTSEVKTTESIVTSTEAPITSEVTTTESIVTSTEAPITSEVTTIESVGTSTEAPTTSEVTTTESIVTSTEAPTTNEVTTAVNTETTVAVETTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDD9</accession>
    <name>A0A0N5BDD9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDD9"/>
    <dbReference type="STRING" id="174720.A0A0N5BDD9"/>
    <dbReference type="WBParaSite" id="SPAL_0000402500.1">
        <property type="protein sequence ID" value="SPAL_0000402500.1"/>
        <property type="gene ID" value="SPAL_0000402500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000402500.1"/>
        </source>
    </evidence>
    <sequence length="942" mass="106665" checksum="784CB04915F1F4C4" modified="2015-12-09" version="1">MIEISKGIDQVTQSSIIRASVDISRQLTDSTITGSFSFKQPKINCQCYGYGGNEKIFVKSDMAILKLAYIRKHFFNSPSSERIHEGKMIQMPCTPPESDPPSEITWYKDGVKIDNSFDSNLILANDGSLIISSTRLNDSGNYTCEAKNIANKRISEPGQLTVFVNGGWSPWSEWSGSCYVNCNLLLENVKKFNGDEQILQRLMPSQRRTRLCNNPPPLNGGDSCNGEEEQYNECPHTCEDYFGQWSEWSSWKCQDDADNHLSSNDGVCLGPSQEHSFCLNEDFSKNNNNCSILIKSLNPSYDHINDHHQQFNRNHFPLNNMNNQVVGNGMSSRDLNIQWTSQFVTLSILGLVSFIILLLILIILTFMCLRRLSIKKRKKDLRCHHYDKETVRTVLLQQHPNTQVATLSNKLNSFQYDPPDNTNNSPFPYNFTLNSKISGNSNYSFKNSANKSTCSTALIVNFDNYSNQKYHHTKALSVSGDNYSSDDNYASLYDIDTETIQHSSTSTSNKLYQDDVKDKFATIIAASIEPCGGKIKLQRNGASLLISEGTFIRDKMLFLALSDDVKDMPSVGEDEHHLSSLVMCGVCDNEVYSNTNFKNEMLKPIVLTFDHNASLFPKDNWIFTLYANYGLNDGWHAVNSFSSIESISKLTDNENNDCIFMVEREKCHVMSHKFGQFLLVGKSKKKSNQPSKRIHISAYISRNEFNGSKVCPTSLRLYFVPETGMAVENVRKQEEHLGYLVVEGENFLLKENGSLCCKLFNQSNQEIQAVEINENNHNWCSQNGLHIVVNLPSQNYPFTGYVTIYQNGNNFSEPTQLNINLMDLNLNSVMTKSIFYDDKLVSNDFLLNSMVKTQLAYLIDKEPFMLKSLSKKLGMEQHLTFFKNNNVSNSMSPTGLCLELWEAVNEGSERAILDLLQTIRVLGSTEGVILLENYVASLFDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF44</accession>
    <name>A0A0N5BF44_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF44"/>
    <dbReference type="STRING" id="174720.A0A0N5BF44"/>
    <dbReference type="WBParaSite" id="SPAL_0000461300.1">
        <property type="protein sequence ID" value="SPAL_0000461300.1"/>
        <property type="gene ID" value="SPAL_0000461300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000461300.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14424" checksum="A4F949294A522117" modified="2015-12-09" version="1">MAGDKVFKREEVKGHTTASSCWIIINNQVLDVTKFLDEHPGGCEVLLEHAGGDATEAFEDVGHSTDARQMLPEYILGDIVEEEKWVYSSSKKNTDKVNQEIVTQGPIEAMIYPAMLVIIAAFVYYLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF50</accession>
    <name>A0A0N5BF50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF50"/>
    <dbReference type="WBParaSite" id="SPAL_0000461900.1">
        <property type="protein sequence ID" value="SPAL_0000461900.1"/>
        <property type="gene ID" value="SPAL_0000461900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000461900.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="79913" checksum="0F5A870486440BA9" modified="2015-12-09" version="1">MATNFLKKLISRSKSRSISPSSRSISSTNSAKLNKKLKDDFNKQPFLFNLNAQDPRNFFDRTMDEINFEYYNNDKREIRKQDHERKSRRRSPTFNAHIVSQDNVSYAGFHKHEREAFNDDDLYYHKNFYRKKSDKNNYKNDIEITNNKLLNFEKEEYPFNNYHSAPNSPPKYMYDSRQRLGDFISPSMLYKQDTEVNGVIGNPYDFSRCNINRYNSYNTLQSNMFGDPKIVKYQSLGSPFTKSKNKNISNYSPNHLVVENKNDAKAKISSKNISKEENKNVDEPIYESLKRNRSSSPKRVLQHPIEISKSGGTLSKDPNSEKSGEKKRAVSKSPSKRSTASTKSKEKIERSASAHLFKISSSNIKTYNYLSPICKKVGCMATIYVTNPDSTTSKFLVCKSQLSHVSSYFRNLFMENSSLTIPGVKQHSINTYTLVVSSLPFPKPSLQFQWYIESTVADPVLREVSTDNLETLMRLSKRFSTPSLVIRCSQFIINEVSRKPPMIALCWLNWIIKHKFDQGCYEAVLPVVSRMSLVDLERHRAMLSEKIYGDILSSKLRCVYKQVSTIFKVIHQIDHFVVEGRVCPRCERTGNDGKSLGNKVRLKVSPCTKIIGCNNCYKNSECELEKKGNGEYEAYFKCDHDLKVFGEKTEDCWCQEMTYKESFLKFESLYPLESRKVKVKDEEKKENEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFA8</accession>
    <name>A0A0N5BFA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFA8"/>
    <dbReference type="STRING" id="174720.A0A0N5BFA8"/>
    <dbReference type="WBParaSite" id="SPAL_0000467600.2">
        <property type="protein sequence ID" value="SPAL_0000467600.2"/>
        <property type="gene ID" value="SPAL_0000467600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF22">
        <property type="entry name" value="PROTEIN ENABLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000467600.2"/>
        </source>
    </evidence>
    <sequence length="477" mass="51986" checksum="AD5EA0839AA5FA0F" modified="2015-12-09" version="1">MSESILAQATAQIYLFDRSTKRWITPDGLDTSNDPQSTNQLAQILLLHHAGRRSFRIVGMQRDGRGVIIETKLFARIKYQKANETFHQWRDEQKQVFGVNFADNYEASIFYQNVIKVLNTIEDNPNIDPGGDLYQDPATITNGRVGIKQQNGMINGSNSTGYINGIHHDVDQDSLASSNSHGYLNGNSQMGAQIQAMNNAGVLRKPSYVIPQQQSNPNLIAQQNQRRASQGSSGSSTHSSTNYSVPSNGNNNGTNAPRNAPPPPPNISSKPNNTTVNNPPPPPPPLPVNLKTENKANSLADQLKKAQLKKVSSIEGNGPSVVTPKPSISANKGDLLSELAAKINKRKNQEEINSNGSGDSVNICERKPSEIVSTNGVLAQNNSSTNLRSWKQTTSNGDSNGNGVDSPKTHRKIPSVSSLSSQEDPLKNVNNTLVPVTLGDLERHKQEVLTEVQKKLQSFKLEIVQEVVAAIRNELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFJ6</accession>
    <name>A0A0N5BFJ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000476200.1">
        <property type="protein sequence ID" value="SPAL_0000476200.1"/>
        <property type="gene ID" value="SPAL_0000476200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000476200.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49777" checksum="E70315670F4E161C" modified="2015-12-09" version="1">MIVDEVHSYSQYLKLPFEFTFELESDGLFLATYTHNQITAIGRGKSKKIAKEEACKNLKPFLQSFAEELSGSTTAECLLKDLVQKIGKSVTYVENMLSDNNIQIKCIVGEHETYATAAICEVAKVKSIKSMLEILSSSIDDVKEKINWADMEKFLDGFFFKMLLQQICDKNSWDLSFHSTESNITREYYVSCKIKSNNDFNTSVPPIEDIKYNSVSKTEGENSLAREICLKYFNNYNDNIYALMKIQLDHRVQKFYDGRKVEYKIERLSMRPSIFKCYCDFSKLSTEGIHAKKKVAQGIAAWKMLKILGESCENNNLKEKKDEENKAIQIPICTDENMDDFNTITIPIDPTTIEKTFRNYHSYLKDILIGDFKFFKSKKSKYILLFKYILLNPKSDTNYCRILFGVGSTKDGAIKQGCDNLYMVTSMKKKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFV5</accession>
    <name>A0A0N5BFV5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFV5"/>
    <dbReference type="STRING" id="174720.A0A0N5BFV5"/>
    <dbReference type="WBParaSite" id="SPAL_0000486700.1">
        <property type="protein sequence ID" value="SPAL_0000486700.1"/>
        <property type="gene ID" value="SPAL_0000486700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000486700.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32083" checksum="9843E48819655D22" modified="2015-12-09" version="1">MEKSESSLVIDVGETEEGENNSNRELLDEENKSSSLVNVSAIGGDEKKSKGWFFPLLGKRHTTPDPQSTSQKSLSKNTNQGHQPTTSPLSSPISGGNTSFNIFQKLNIFSKPTNVSTTPPLIVDTSTSNNDNGVDEKNKDDDTVTENSRSINVEETFSSPKIERWYDPKVLSPIKFNLDDSHPLEVECFSNKSMFESKLLDELITDFRENKLKAFSQENLEQLRFMHKQQLEISALHAKLSMEEALNSFKDVDKLDNEFDVLSQKLEELHRTMEEFSPGISVMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGS3</accession>
    <name>A0A0N5BGS3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGS3"/>
    <dbReference type="WBParaSite" id="SPAL_0000517300.1">
        <property type="protein sequence ID" value="SPAL_0000517300.1"/>
        <property type="gene ID" value="SPAL_0000517300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000517300.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8588" checksum="B87ED28A65E0BB7B" modified="2015-12-09" version="1">MYCGMGCLCIKEERKVYFASAVEAINGRASHWSSGSRKTNYYNDACDTLWQTSDFPWPEDNLNENDNDDNIIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH84</accession>
    <name>A0A0N5BH84_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH84"/>
    <dbReference type="WBParaSite" id="SPAL_0000532900.1">
        <property type="protein sequence ID" value="SPAL_0000532900.1"/>
        <property type="gene ID" value="SPAL_0000532900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="132"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="171"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000532900.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="55362" checksum="5CDFCC51AE7D9316" modified="2015-12-09" version="1">MKQNMWISTIFLIIFSIIFLICGDTLTYNRDLEHTAEALRKIDQMYRRVRRRAAPMRGQQQKPSIFGRISVAVKNSYRRVKALMNPRFYQGDILLVQRQSQSLLQQIRSGIFKNKRIRVPSFGFGNANRTKRRVKADIAFKWNGPIPFYVDRGVPDTLIVKSLLEIQKETCLRFQQVRSAGTQSSGLRYFLGQGCSSYVGKVYDDKFQDVSIGSDCFEIGLVQHETMHALGCFHEQSRLDRDRYVEIIQQNIPQDKMRNFLIIDVDDGVDYNLPYDYVSIMHYSLSLFSKNGQPTTVPKLKDYMKSMGVGDRVSFLDYKFLNLHYCSQVCPRPIQCSNWGYQDPNSCTRCKCPSGFDGQYCEKVASMPGNCGQPAYKAGPQIQEINVSGFKNCYFVVTAQPGQRIAYKLVFSYISPGYVEYCTIQNCMEFKFFKDKSVSGARYCLKDMETVRISDNHFLMITYNSNGTNNKATVLYKAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHE6</accession>
    <name>A0A0N5BHE6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHE6"/>
    <dbReference type="STRING" id="174720.A0A0N5BHE6"/>
    <dbReference type="WBParaSite" id="SPAL_0000538800.1">
        <property type="protein sequence ID" value="SPAL_0000538800.1"/>
        <property type="gene ID" value="SPAL_0000538800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000538800.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="87978" checksum="0EFD3ACC28D25E02" modified="2015-12-09" version="1">MIRRELTILTSRWIVSRSYLKQHTPNVKEIIAKRYRTLIEEGKLKNKNTDPKNVVAFESLAAERYIKSMDEELFTKVTEHQKESLNQLNDKYNENHDEPTFPMSNAASVDFISYNEKKCKDLFTNPQMEKGFHVRSDDLVQEYREGYVGELENDELTVPEVTLHGPEDAVERIDFQLPGQASNRSLNKLNSKPQETNKVEALPEEIKIEADIPPSKMACAGCGANFQCNNTSFPGFVPYNTFTEIENSSRYRKKSSGSTYNNTLCRRCHLLKEHNFLLNVSVSPLDYEEMMGDLKIKEALILLVVDVTDLPYSIYDKLPDIIGHGKPIIVIGNKVDLLPPDARDGYLKNFSNVLYKALQDTGLKDKFNILHIALVSAKTGYGIEQLITQIYLKWTDLKDNVRSDIYLLGNTNAGKSSIFNIFLQSDLCKVRAMDLVERACASPWPGTTMSLLKFPVMNLSSQKLEIRRRRLLSVQAWLKKEERNRWMLLKESKDPRYATLMGVVDSSFKSIDAQHQPESFDNVKAAFGYDIDLSSKENEERKKFFNPNDPQFVKGTWCYDTPGVVSDSQLMNIFTLDELIKIFPRKIMIPRTFILREEQSLLIGGVVEVMSKDTSVLVTLFCSEKLPVNIMKSDEVKEFLDAYLGKPNLVVPCGNQKRMEAYPKFEGQTFEIQGKGMEKGSCDITISSIGWLMVTSKKEQKNTITVKTPGGKGIFLRDLPMLPYSLSFRGSRIGGTQEYKTRTIPFIKQTKERKGNDKNYRKFRNNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHH5</accession>
    <name>A0A0N5BHH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHH5"/>
    <dbReference type="WBParaSite" id="SPAL_0000541500.1">
        <property type="protein sequence ID" value="SPAL_0000541500.1"/>
        <property type="gene ID" value="SPAL_0000541500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000541500.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11463" checksum="BC0DB5F6763B5670" modified="2015-12-09" version="1">MASFQFHELNQLLIGFTFLSAAIAIFLAFFCYCGAKTCCKARRKESTSSESGVLTKHIKTNTNEPLLTSVSYTSNIESPEIAFIDERITNVVSSTVKVNSLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHR7</accession>
    <name>A0A0N5BHR7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PARP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000550400.1">
        <property type="protein sequence ID" value="SPAL_0000550400.1"/>
        <property type="gene ID" value="SPAL_0000550400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000550400.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13703" checksum="BEE9586C0EF08308" modified="2015-12-09" version="1">XRNCEYRMTKDNEKNSDISRGEVQSESLLNTNDSKIPSSNGNKEIRIVSKEKLKINVKMFPINGRKIQDESSCYICTDVVSNSQPVKEYKRVTAKMLRGSGYKFHFGCRELQDKHSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI64</accession>
    <name>A0A0N5BI64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI64"/>
    <dbReference type="STRING" id="174720.A0A0N5BI64"/>
    <dbReference type="WBParaSite" id="SPAL_0000564700.1">
        <property type="protein sequence ID" value="SPAL_0000564700.1"/>
        <property type="gene ID" value="SPAL_0000564700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000564700.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="31223" checksum="7DF8B4DE9F487C67" modified="2015-12-09" version="1">MAMRNAFMNNNMVFKYGVNITGSKVPNLCFADDTCVLANSWNDLSLMVDKFIRACQPMGMELNMNKCKILMSKELSIQYEKDKYIPLNLAKMQVSNEEEYLGKIVSITEKRCFLKQVRNRAWKAFYSIRKFLNISLRARKLLFVIRIRSSMCYAAQSWTTTQAERNNLISVERSIIRRLKLIPEDKWLIKEEENTFKKLSNEDMYKEIGICNLNRHLAKLKIKFIYKKVDENGIVQRCLCWYPHGTKKRIGRPRDSYFDCFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI80</accession>
    <name>A0A0N5BI80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI80"/>
    <dbReference type="STRING" id="174720.A0A0N5BI80"/>
    <dbReference type="WBParaSite" id="SPAL_0000566300.1">
        <property type="protein sequence ID" value="SPAL_0000566300.1"/>
        <property type="gene ID" value="SPAL_0000566300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF3">
        <property type="entry name" value="PROTEIN GVQW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000566300.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8115" checksum="67592789CF8950AB" modified="2015-12-09" version="1">NDKIRCHFSKLVLKKLGELKYETLSHPPHFPDLFLTIYNLFEHFDIFFKDKLFKNQESSESDLSDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIQ9</accession>
    <name>A0A0N5BIQ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BIQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000583900.1">
        <property type="protein sequence ID" value="SPAL_0000583900.1"/>
        <property type="gene ID" value="SPAL_0000583900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000583900.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="71681" checksum="FBF5E9C2EFD25D09" modified="2015-12-09" version="1">MCNILRTICTVLTTVVLVFIIFYLTSLILLLFFPKESIFDYADKIAYKIYYFLPYDVYRFFTGTKNLYNIFDIEAQHGENSSAPPSFTYYAEDVDGFFVYYMNTSERFTETNIVFRNEISLFNSVLCTYCTLQQFIGRKDLHMVNLFGVPVGLYHIIKSASSYKNVCLDTFNGLDREHCPKKSFMANRINVSERFVPDNVKPFWKPKYTSGINCKRIIDGDRKYIKEIKDKPIKYKEEELKMDCNSIRERSFNLKYIPTSPLERRYSLAFAYNVYKAYPILERRLSSQYSPNNHYCYFVDIKSPDVFKKLNQLAKCIPNVYVVKKQYNMTSGGDYATIAHVECMKLLLEKKWDYLYLQQNDDFPLKTPRQQLEILESMNFPVEMSFVDPSSTVPFRYNTSLSWRYKDLNFFLKDDYRNMYKSKLLEKIVFQKGCVCTGLPRESVEYLVYKINITTYLNQMNVGIYGNDELAWQTLFTDDFLNIPGSIPRKCVHIYRPRESYLVRRVSWEPEECPTKTYHHSICTWGTETLPEMDSYPDFYGYRFRGETDYGAEVCWMEHLYNITHFKKHKRRDLWYYYNLPQSVFQRLRIKNDEEAIKTCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ17</accession>
    <name>A0A0N5BJ17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ17"/>
    <dbReference type="WBParaSite" id="SPAL_0000594433.1">
        <property type="protein sequence ID" value="SPAL_0000594433.1"/>
        <property type="gene ID" value="SPAL_0000594433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000594433.1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7123" checksum="39445F307BCCCE61" modified="2015-12-09" version="1">MEWGNYLEIILFLNYKDLKNLQTIVNSTVSFIGGDVAQIYNDVSKLEKIVEKDYIYFYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ27</accession>
    <name>A0A0N5BJ27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTPase_I-T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ27"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ27"/>
    <dbReference type="WBParaSite" id="SPAL_0000595300.1">
        <property type="protein sequence ID" value="SPAL_0000595300.1"/>
        <property type="gene ID" value="SPAL_0000595300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000595300.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26946" checksum="7089AF5B4F6D7C80" modified="2015-12-09" version="1">MQLSAKRLLIFVSGNQYKIKDVIATLPNTLKIEVKDLPIKEVQGSVEDVAYEKCLSAVTLTQQEVFVEDTSLCFDHWKVLPGPYIKSFISCLASLDLYKLASILPSQKATLVSAVTFGVPPQKGSYTPRIFMFTGVRRGIIVKPRDCENALKSFEPVFRSNNSGLTISEENESGTRLKYSARVDALKSFVKAYEKYKETKNLDSIKEYEINHTLFAKPETPSRILDPNINPKDMLNIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ54</accession>
    <name>A0A0N5BJ54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ54"/>
    <dbReference type="WBParaSite" id="SPAL_0000597900.1">
        <property type="protein sequence ID" value="SPAL_0000597900.1"/>
        <property type="gene ID" value="SPAL_0000597900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="177"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000597900.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30723" checksum="23D3B1B3D20E5A99" modified="2015-12-09" version="1">MDKEFLMDKEFLWLFWLFLWTWLFLWLGFSYGQRISYSWRTQNGVTVYNFNGKDYTSFEAVKEAIKKEFPNVQFQSPNSGRSTNNGLGNRTPNRSPSSGSSKRKPNRSPNGGSGKRNPNRSPNSGSRGRITNSGYGKNNGGFDITPYKGNNTFSNKIFDEVWDNYNYDTDSQYGFTDMKKRFLTESNKYRAAHKVPKLEEDWTLAAKAQNYAKYLASINQLIHDPQNSNDNTGENLAFGSPWISHLAVKNWYDEISLYDFKKPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJR7</accession>
    <name>A0A0N5BJR7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dimer_Tnp_hAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJR7"/>
    <dbReference type="WBParaSite" id="SPAL_0000618700.1">
        <property type="protein sequence ID" value="SPAL_0000618700.1"/>
        <property type="gene ID" value="SPAL_0000618700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000618700.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33371" checksum="5532A4AF264F3A80" modified="2015-12-09" version="1">MECFKLMHHIYTYCVSIGRRDKVNSYLKQHTGKGIILVPKIRWIYAYRMIHRFNQLSSQLKGFGDFYFDNEDINVAKETESLLNVLYITSENMQNNSFGMKDAVFVLSELDFLVKKLQIRDQFKNAYFETAKKRLSDVLDISKNPIFYISAFFNPNVDKILCLTSSEKEIVINVLQKKFNLNNGIEAVDNNDEHKSNYISELRKNNNKNINSVIFSNPYFQTQPYFEFGNINLQKYYKAIITTPASIARVVGTFSHSKMLLDGRKSRTSMETVKMKLFINFSLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK72</accession>
    <name>A0A0N5BK72_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="8">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.</text>
    </comment>
    <comment type="function">
        <text evidence="8">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK72"/>
    <dbReference type="STRING" id="174720.A0A0N5BK72"/>
    <dbReference type="WBParaSite" id="SPAL_0000633600.1">
        <property type="protein sequence ID" value="SPAL_0000633600.1"/>
        <property type="gene ID" value="SPAL_0000633600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000633600.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27437" checksum="83E988D06F6648B6" modified="2015-12-09" version="1">MRILVGVKNVIDYAVKIRVKPDKTGVVKDNVPHIMNPFCDIALEEAVKLKEAKKATEITVMSLGTDKSSTILRTALAKGADKGILVQVDAKTNEKLEPLHVAKALAAIVKRDKYDCVLLGKQAIDDDCNQTGQLLAGMLNWPQATFANKIEAKDGSLDVVCEIDGGLQTVNVKTPAVITADLRLNTPRYATLPNIMKAKKKPLETLKASDLGVSLDNQTEIVEVTEPPTRSAGEIVPDVKTLVSKLREKGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKE1</accession>
    <name>A0A0N5BKE1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKE1"/>
    <dbReference type="STRING" id="174720.A0A0N5BKE1"/>
    <dbReference type="WBParaSite" id="SPAL_0000639900.1">
        <property type="protein sequence ID" value="SPAL_0000639900.1"/>
        <property type="gene ID" value="SPAL_0000639900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000639900.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19875" checksum="C2FAEC9E003D577C" modified="2015-12-09" version="1">MKNNDDRPLEVSYKKPVKLTKKAKFGEKPRGFDPRFDRRCGDYHEGAFRKSYSFLNEIRQEESKALKEELQRCKNTDPERASKIREILKNRKTKEINEKMIDLKKEAINEVVRNNIERMNSGKKPIFYKPNQMKERIAKKKYEYLKEEGKLNKYLEKKKRNAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLA5</accession>
    <name>A0A0N5BLA5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLA5"/>
    <dbReference type="STRING" id="174720.A0A0N5BLA5"/>
    <dbReference type="WBParaSite" id="SPAL_0000670400.1">
        <property type="protein sequence ID" value="SPAL_0000670400.1"/>
        <property type="gene ID" value="SPAL_0000670400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000670400.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28493" checksum="F934BFE60B0E540F" modified="2015-12-09" version="1">MKSPLFDSKKNDTMKWRLYIHSQGSYISLRLELIDFDDIELLALCGFYILSVYGEKKHAKTMKIQKIKKAKTHCFCSKFLERDLLRNDDNELLPDGNLMVGCEIFYYYRTINNIGFSTNTNLNESLDVLLDDKTGMLDSPNSSDCVIRVKKIKINVHKYILAGKSEVFNSILTEKQCESNPSIITIYGFSPKVVKEMIEYLYTGKSPNMDNMACPMLKIAEKYKLKQLKLMAEKSLIHSLSIGNACDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLK1</accession>
    <name>A0A0N5BLK1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLK1"/>
    <dbReference type="WBParaSite" id="SPAL_0000679700.1">
        <property type="protein sequence ID" value="SPAL_0000679700.1"/>
        <property type="gene ID" value="SPAL_0000679700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000679700.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22522" checksum="507F95139B919A96" modified="2015-12-09" version="1">MISDDIYSFTKTKNKTKKNTKVLQKKTRSSYIKNTFKKIVVNDVPLPSEYQILNNSRLKKHLSDVKDNKSGIEENTESRYFNLSKKNNGHFNVSTSTVSTPSTILPISQNLTNYQNDLVFGRFNLWVLIAFSLFYGFLIIALIIICRIDLKVRNTTVACRKKASKYDSDFSKTLSNLPPSLTPPKFHDENDIKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLZ6</accession>
    <name>A0A0N5BLZ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLZ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000694300.1">
        <property type="protein sequence ID" value="SPAL_0000694300.1"/>
        <property type="gene ID" value="SPAL_0000694300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000694300.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="10156" checksum="0B9A5AE4764EADAF" modified="2015-12-09" version="1">MSEKLREIYSVYGEDAMGWSTAKYWYKKFRNDNFDLQDSSRTDRLSIFDEDRLRKDNRQTCGELTKKMNIVTHRKKKDTGLHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM49</accession>
    <name>A0A0N5BM49_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM49"/>
    <dbReference type="STRING" id="174720.A0A0N5BM49"/>
    <dbReference type="WBParaSite" id="SPAL_0000699200.1">
        <property type="protein sequence ID" value="SPAL_0000699200.1"/>
        <property type="gene ID" value="SPAL_0000699200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="216"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="428"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000699200.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60540" checksum="DE5018B898CBC04F" modified="2015-12-09" version="1">MNECYNGDNDYTKEEFTNGYENYESNFKVKDENMDNSTSPSDKNGQKYKEERHDENEERRVKEKSRSEKDRKRRDSEDRDRKKDRSRRDDRDRKRHRSKERSRSRSRSRAKDKSRSRSPKKSRRRSRSKDKDRSRHDRRDNKERSSRGEGRDTKGDTKESGGRPRRTYRFWDVPPKGYEHMTPREYKELQANGQIPRNNMQSAVPVIGPSVTCQSRRLYVGNIPFGCNEQTMLDFFNQQMTLCRLSQAPGNPVLACQINLDKNFAFIEFRSIDETTAGMAFDGINFMGQQLKIRRPRDYQPIGNDMMTNYGISSVVQDSPHKLFIGGLPTILEAEQVKELLQSFGPLKSFNLVKDGKTGISKGYAFCEYADPALTDQAIAGLNGMELEDKKIIVQLACTGAKNPTTDSSGNTPLSGIDLSQGAGPVTEILCLLNMVTEEELRDDEEYEDIVEDIREECSRYGEIRSIEVPRPIEGLNVAGVGKVFIEYASKAECQKAVAAITGRKFDNRIVCTSYFDPEKYYQRAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNG7</accession>
    <name>A0A0N5BNG7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZnMc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNG7"/>
    <dbReference type="STRING" id="174720.A0A0N5BNG7"/>
    <dbReference type="WBParaSite" id="SPAL_0000744600.1">
        <property type="protein sequence ID" value="SPAL_0000744600.1"/>
        <property type="gene ID" value="SPAL_0000744600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF329">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894597" evidence="9">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="10">
        <location>
            <begin position="125"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000744600.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39330" checksum="866CD77E71E291E6" modified="2015-12-09" version="1">MYQLFKLLITIFSLNICDSFDNFDLFQLLSQRDPNVVYHSPIPEKLVNEYLQNFGYINQTLLNETNIPELIPNNLLAESLIEFQKFSGLPETGVLDDETKIKMGAPRCGISDIDADNKSDIHKRSIARWGKSTISYTINKYSNKLDITDSKNGLIEAFALWSAVVPLTFYETEYNGDVEVKFATGRHGDDWPFDGSGGTLAHASLGPGGFLHFDDAENWKYVKESDKLSSNQIDYLSIATHEIGHVLGLKHSEDPSSIMTPFYKSNIDINGNYIKPKLSYSDIQNIQNIYGGSLSKENTLYYLFNGLSTNFYNNDGPQVQNNPNINQGQRYGRYIPAYFYYFPLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNQ6</accession>
    <name>A0A0N5BNQ6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNQ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BNQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000753300.1">
        <property type="protein sequence ID" value="SPAL_0000753300.1"/>
        <property type="gene ID" value="SPAL_0000753300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000753300.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7900" checksum="B63AAAF27C8287F4" modified="2015-12-09" version="1">MIIPIRCFTCGKVIGNKWEEYIKLLQEENTEGDALDALKLKRYCCRRMLLSHVDLIEKLLNYSPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPE2</accession>
    <name>A0A0N5BPE2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein okra</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPE2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPE2"/>
    <dbReference type="WBParaSite" id="SPAL_0000776800.1">
        <property type="protein sequence ID" value="SPAL_0000776800.1"/>
        <property type="gene ID" value="SPAL_0000776800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="173"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="503"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000776800.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="88719" checksum="008A9545587DDB1D" modified="2015-12-09" version="1">MRRSLAPSYENGVTPARPEYKDKVDKKTKALKRKAESYPLVPCEAYFPKCKTTGVEVMRKRLKMTEDDDYAEHEKMIQKIINSKFKIPIDGYCGARTQKTLGLRKPGVKRALWDPYMENALVLYTPPELTEEQKTTIDEKDKLVHVVVDPLLGNILRPHQREGVKFMYDCVTGSKIENNYGCIMADEMGLGKTLQCIALMWTLLRQSPLGKPTFSKAIIVCPSSLVKNWDNEITKWLKGRINPMPIDSGKREEIRDGLTRFMNERSLYSSIPVVIISYETFRIHVDILSQSEIGMVICDEGHRLKNNENLTYQALSSLKCSRRILISGTPIQNDLLEYYSLINFVNPGMLGSAAEFKKNFENPILKGRDSLSDEKQRKLSEDKLQELSSLVSHCIIRRTSALLTKYLPVKYEFVVCCNLTELQENLYKQLISTKKIDVNKRTSEGAITGQAFTFITSLKKLCNHPQLIYDRAMKKESGFENCQFPSGFAGTKLDPRWSGKMWVLDYLLAFTKRESSDKFVLISNYTETLDTFVQLCRIRGYRYVRLDGSMSIKKRGKIVKEFNDPESDIFIFLLSSKAGGCGLNLIGANRLVMFDPDWNPANDDQAMARVWRDGQKKTCFVYRFLATGTIEEKMFQRQTHKKALSSCVVDEQTEVERHFSAGELKSLFELRTDVNSDTHEKLKCKRCTNGKEIKSPPDDADTNSDLSLWHHTTKDISKIPDTIFRGVLSVPKAPISFTFFQKSHDKEVQKKAPKKSEEDKDSDFENRGDESDYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR35</accession>
    <name>A0A0N5BR35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR35"/>
    <dbReference type="WBParaSite" id="SPAL_0000833900.1">
        <property type="protein sequence ID" value="SPAL_0000833900.1"/>
        <property type="gene ID" value="SPAL_0000833900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000833900.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13656" checksum="251A8B9617DD3112" modified="2015-12-09" version="1">MQKESITNRNKNGSLTLNENIVDNCGIKLAHTAYMKYLNTTDDEQEHVPAFKKFTKEQLFFISVGRSFCKYSNKDYLETTINKDVHSPSEIRINMVLSNYRQFFDVFNCPVNSKMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR43</accession>
    <name>A0A0N5BR43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR43"/>
    <dbReference type="WBParaSite" id="SPAL_0000834700.1">
        <property type="protein sequence ID" value="SPAL_0000834700.1"/>
        <property type="gene ID" value="SPAL_0000834700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000834700.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9594" checksum="D0EF7E9AC65F8419" modified="2015-12-09" version="1">MSVDINPNDESLLDDDGVVNPNNSITNEKEDGNKSPKLPKLPSNLSLEEDKSKKRKANSSIEEYAKKLETDNRTLESYFLLQLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS58</accession>
    <name>A0A0N5BS58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS58"/>
    <dbReference type="WBParaSite" id="SPAL_0000870300.1">
        <property type="protein sequence ID" value="SPAL_0000870300.1"/>
        <property type="gene ID" value="SPAL_0000870300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000870300.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="91490" checksum="6939223219AC2556" modified="2015-12-09" version="1">MEIQERQLYTCHFCTFKTNDSDRHKRHEYYCHIVEILFPPSPGSSPGYCGSYICDDDSEEIEQYTECIIRGCESIIVDKCLTRHVMNRHCDDNVPFQCKYCFRFFSNHVSVLYHAIECTRGAISIYFHEEELKLLKLCVNNKKGFNIYKESFETYLNHDVKYNIWEYNEIENKSSTFPQVTVGLSLKIIQRILDSFFRCKSIQRKQLEEAFSVSDSNNFDEMYHFFHSIASLFPSVFNALVPIVQCCENRYTDPQLCTCNKINIYKLPIYDEKYEEIELQDDLPPLIRTPNNVYCYALNPNTFFINGTHQFLKIIDGIFLDTDGIYGTILLSVIYRDIFEFMKMDDSDLNSHLINYGYNNDRERRELITIIRNKSFLFMNNKNAIEGEERSLLDDTIFLPTCTFTDDSKAERLKHFIEEANSYFSSGTFNGDIKMVNNYTMPLYDNINFGVRSKNRRIEPTTSSRLAIALKNVIASYCTAPDYAIEECLKKVELSHIYFCINDDDAFCSNDTDGSSIFDCDIENSYDFNSLNHHIKSVELPFYEPDSDYEDDSMFYKRMMELSNVFNSVGDFDEYNDLIIQEDNNDFLEIFNYTMPCTPPMADVTSKDYNYIVDLTANNNITQYEPYFSDQHTTFVDNVEYLQNSLSHQSLMIYENNLNNLYQPLDLSINNINDSCNIQNLPCKTPRNFLPQEVFFQPQPICTIQNSLLNRFSILNESINFYYFSPVNVKNLHDVCLDNLNLCKFSERIENKLHDRIVKILQSKKRLSKGYKILHKAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSL1</accession>
    <name>A0A0N5BSL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynactin subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSL1"/>
    <dbReference type="STRING" id="174720.A0A0N5BSL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000885300.1">
        <property type="protein sequence ID" value="SPAL_0000885300.1"/>
        <property type="gene ID" value="SPAL_0000885300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000885300.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39525" checksum="E096A36FED96966D" modified="2015-12-09" version="1">MEYNTKEQVWESEGTIRPNSPPEEETFDSEDIVKIHVDLDEAKRKFHGRILNADHVNFADPFAKTRNRGYGSGSYVLEIVGSDMISSGETIDQKFNRLYYEIDELRDQVDEAKEKDTEDYKNSVNKNKIILLSEMIKNVALMKESNDVNKLTIENMENLEEKSKDNNLNGINKDMYIAQLENRITELEKRIGVNTMLNDSSTLLEKLESLKILIESLNINHYGAIEKKWRDMKSAVSSNAEKIFSDPNNEAANIEKINSLHELTGRWDATCQLLPSVVKRLQSLAALHEEAETFSEKLTSLDDAEKRLSNELKIEKESLMSFQDKFASMISNLMMRLDKIETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTB5</accession>
    <name>A0A0N5BTB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase POLQ-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTB5"/>
    <dbReference type="STRING" id="174720.A0A0N5BTB5"/>
    <dbReference type="WBParaSite" id="SPAL_0000910200.1">
        <property type="protein sequence ID" value="SPAL_0000910200.1"/>
        <property type="gene ID" value="SPAL_0000910200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="122"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="337"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000910200.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="66069" checksum="8627C4BAE2039EF3" modified="2015-12-09" version="1">MSNQNKRVYVGKERSNDEIGGGRRPGSLSPPSSKKVKKDQDDTESLERMTRQNYVNTIGVEIVTSDDDLDEDPFDDPDSNNCTLSTDDVFKRIGLSQNVRDFYKNERNISNLYDWQKKCLTDPGLLNGNNCIISLKTGGGKTLLAELLMLRESIVKNRSCLIILPYKAIVREIIINMSAFEELEIFTEEYTCSKGRIPPVKRTRGQNIYVATIEKATILIDSLIRENRLKEEIGLFVVDGLHMIGEEGRGAALEKLIFKYLMLGSGQIIGMSSTLGPVGDMRKFLKARLFSSDFGPFKVVERVKISNNLYNVNDEGDLIPYSKMEIYDKNRNVDSDGIFSLVKDIAPQKSVLIFCPSRNDCKYVCLMVATHLSGLSGIPDERRQQVIDLIKNGNGGKIDEVMEIGIRAGVAYHHAGLTDNARHCIETAFREGNLYALCATTTLSEGVNLPVQRVIIYQPKVGIDFLEKSRYIQMIGRAGREGYENEGESITIVGEEYIEKFLDMLKSPLKPCQSQMLDKVNLEGFIMDLIYLKLVKNVEELRDSLLKTLAGIQDNDECLSLMEGILESLKTHKIVKIENGVIQRLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTX0</accession>
    <name>A0A0N5BTX0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligosaccharyltransferase complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OSTC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTX0"/>
    <dbReference type="STRING" id="174720.A0A0N5BTX0"/>
    <dbReference type="WBParaSite" id="SPAL_0000929400.1">
        <property type="protein sequence ID" value="SPAL_0000929400.1"/>
        <property type="gene ID" value="SPAL_0000929400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042416">
        <property type="entry name" value="OSTC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160:SF4">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000929400.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16522" checksum="EF0C8E8AB96E4C26" modified="2015-12-09" version="1">MDSFLENTVFKVVDPPRLKLTIPSYIRLLKPMETFFCVMVIYFIMTAGTVFNILNDIPSIGSAPDGKGGYKPVVIMPNRLNAQYGFEGMLASFMYIIGAGGFILLDKFHETKNNRTKIILGSAGASALVISFLALRSFMFMKMPSYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUQ4</accession>
    <name>A0A0N5BUQ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUQ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000957400.1">
        <property type="protein sequence ID" value="SPAL_0000957400.1"/>
        <property type="gene ID" value="SPAL_0000957400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000957400.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8945" checksum="71B727D9F7425FD4" modified="2015-12-09" version="1">MPMGNNMAMGHGMYGMMDYGMGGMHGMNGMYGMGGIGLMSGLQSMSGPLMGMMYISIKSMLCMRICFRHARYHDDAVSNDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUV5</accession>
    <name>A0A0N5BUV5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUV5"/>
    <dbReference type="WBParaSite" id="SPAL_0000962300.2">
        <property type="protein sequence ID" value="SPAL_0000962300.2"/>
        <property type="gene ID" value="SPAL_0000962300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895186" description="glucuronosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000962300.2"/>
        </source>
    </evidence>
    <sequence length="1007" mass="115799" checksum="40D949D06FB677CA" modified="2015-12-09" version="1">MSLKYFILFFNLFLLPHSYKILIVNPKMGYSHVNFFSQIADILTDAGHDVTVLTINLDPTIKHPGAYKAKVITFLTTEEVEKIFPNMYDNRMLWNLSSSVLDQYKLLVGFIDTRYKQSLKIFNDDELTEKIRKEKFDLGIVEAFHISILGMFKVWGIKDYVTGFSMSLTNIFYKDFGLPFPASFIPTLMSPFSDKMTYKERFQNLFVHHFSKTICYFLNDKLTLQKEFDERYGVGYYKSRNVVGDSSFIFINSNPFLDIPGPKTPKMVEVSGIGIKDPKPLDEYWSKIISLRNKTVIISFGSFAKAIHMPEDMKNGLLEVVKKNKDITFIWKYEEPEDGTGKDIENLVLSKWVPQNDLLNDERLSLFITHGEGFLRGVPAVVILVMGDQLRNARLVERQNYGIIMDKLDLANSDILIKNIETIINDETYRKNAKIVSKRLNKRPIGSKRLLIEHIEFAAEFGRLEMLDLASRNMGMIEYYNLDIILPVIIGLLILIVNPKIGYSHVNFFSQIADILTEEGHDVTVLAIDFDPSVKHPGAYKAKVIRFRAYKAKVIRFPSTEEIDDTYDTNFDNKLLWKLPRSGPEQYKLFVKMTDTTYNQTLRVFNNDELTEKMRKEKFDLGIVEAFYFSILGMFKVWGIKAYVTGFSMSLADNIYNDFGLPFTGSFIPNHMSPFSDKMTYKERFQNVFSHYVGEAVLSYLNNKMTLQKEFDEKYGKGFFNGNNAVGDSSFIVINSNPFLDIPGPKTPKMVEVSGIGIKDPKPLKEYWNGILSLKSKTILISFGTYVKSIYMPEDMKNGLLEVIKKMKDITFIWKYEEPEDGTGKDIENLVLSKWVPQNDLLNDERLSLFITHGGMGSITELSFRGVPAVIIPILGDQYRNAKLVERQNYGIIMDKLDLTNSSILMRNIKTLLNDETYKNNAKVVSKRLNKRPIGSKRLLIEHIEFAAEFGRLDMLDLASRNMGMIEYYNLDIIIPVITGFFLFVLLLSCVIVKIAKKSFIVKYKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUY0</accession>
    <name>A0A0N5BUY0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUY0"/>
    <dbReference type="STRING" id="174720.A0A0N5BUY0"/>
    <dbReference type="WBParaSite" id="SPAL_0000964800.1">
        <property type="protein sequence ID" value="SPAL_0000964800.1"/>
        <property type="gene ID" value="SPAL_0000964800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="12">
        <location>
            <begin position="279"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000964800.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50100" checksum="4641AB5DCC5A2961" modified="2015-12-09" version="1">MKNINGIYKISSKICLNYKATNSILNSPPIRLPYYETQIRYNSGRPRSQGGFISNLINNIKEEFSKNEDLKKNSEALEKRLKELQETEAVKNARKKFDTIEKETSKGGGIVKHKAVELKDHVVKAYHEFEKTEAGKKITEASAEAIKKAKIAGEAVGKVAEKVGETEVYKHVSDVAKDVDSIAKVHMYKKPEQLQMRSSELDTAFANRPIEANTEATGITLHKNAKWYDSWKEYTEKNPYYNKLLDLKMKYDESDNVAVRIVRNAADKLKFVFHKSDPEGEVIREITKIDPNFDVDEWLEFVEKQVIPNILEAYISNDLKVLESWCHERAYKVLATTLKEYQEIGYNISESKIIDVSKVELNTGKMMEQGPVFVISFNAFMINVVKNREGKIIQGDDKNPVRVTHVWVLCRDMEEYNPATAWKVLEIHMHETPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV66</accession>
    <name>A0A0N5BV66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV66"/>
    <dbReference type="STRING" id="174720.A0A0N5BV66"/>
    <dbReference type="WBParaSite" id="SPAL_0000973100.1">
        <property type="protein sequence ID" value="SPAL_0000973100.1"/>
        <property type="gene ID" value="SPAL_0000973100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08959">
        <property type="entry name" value="ArfGap_ArfGap1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000973100.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49481" checksum="4A7459833C2466F7" modified="2015-12-09" version="1">MASGTPSEEEIKQIISKLKAQSYNKVCFDCNTRNPTWATVTYGVFICIDCSANHRNLGVHISFVRSINLDTNWTWHQLRAMQLGGNANATNFFKNHGCESNEVKQKYNSRAAIMYREKLAKIAIYAHETFKGKLFIDNVEDIEFNDKKNEQEDFFSQEFKPVSSVMTVKKKLIEASKKEENRLLDAISPVESQSIKYSFINKPIKKLTLGNKKKLGATKVKKNFDEVEEKAIEAEKDFRILGKYNSEGKGNETSTKISSCFMMKNVEDSNKIIEKQLKIAAADPKKAEIVERLGMNCFQNIGISHNVSSGVQSIKQNNLKPNVNQNFEAKINSNYGSFNECGNSKDDFISHKTINSIQFFSPQERLVEFKNSKSISSDNFFDTKYEGKDIDFAAFSGNIGFGSSDIFDNCEFEKSPISYNSPMLKMFDIKRDRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY64</accession>
    <name>A0A0N5BY64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease P</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY64"/>
    <dbReference type="STRING" id="174720.A0A0N5BY64"/>
    <dbReference type="WBParaSite" id="SPAL_0001072500.1">
        <property type="protein sequence ID" value="SPAL_0001072500.1"/>
        <property type="gene ID" value="SPAL_0001072500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001072500.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9677" checksum="50EAA2DD2CDE7D7C" modified="2015-12-09" version="1">MSQEKKNVEVLKRKESGIIERIISKTKVKGLNYKLINSERQLIEDKNKLIIGIGFKHTRSGPSDTLLVNTGDVGIRRDAEMKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYJ6</accession>
    <name>A0A0N5BYJ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Frizzled-8</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYJ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BYJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001085000.1">
        <property type="protein sequence ID" value="SPAL_0001085000.1"/>
        <property type="gene ID" value="SPAL_0001085000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="235"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001085000.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="78180" checksum="9D0A7633E4056D1C" modified="2015-12-09" version="1">MRYGFINLISYFTLFFIFNIFINVLGKRCEQITIPLCRGIGYNFTSYPNSYKHETQLEAALELNQFYPLVEVNCYKHLKFFLCSMYTPICQENYEKSIMPCREVCLEAKKNCAPLMRQYGFNWPTSLSCSVLPKMSDQGRTGEICAAPPDTPDIIEKDSKMDKYDKNTAKKNQPTLVYPVIGIDVIENVNQKKCECSCQSPFVFTESSEQRIQNVSNCAYSCFGQLPTQKSKDFINTWMIIWAGICFFLSIFTILTFLIETNRFQYPERPIFFFAFCQLMLSLGFLIRIYYGHQNIACSGDLIKIGNHTISSCLLVFILTYYFSMAVFTWWIILSLTWVLASGSKWSNEAIAAYAPFYHLFAWFLPAVQTFLVIILNGIEGDPISDLLYAPFYHLFAWFLPAVQTFLVIILNGIEGDPISGLCFVSNTSHFQRSFVLGPLIVYFSVGVFFLCIGFLNLWHIRSVVKKRQIGSQIVYFSVGVFFLCIGFLNLWHIRSVVKKRQIGSQNANKITQLMSKIGIFSVLYTVPALFYILVLFYEQYYRPLWEQSKLCSCANQVNENENAMYAFSLIKIAAMLFIGWTSGVWVINVKTFNSWKYVICCATSKHLKNVPYINHHNNFGYNTVPCQRNRFCNPPSPQYHQTEIRYAKTNEAMSPQTYGTLRSYNHMKMPMIPDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ19</accession>
    <name>A0A0N5BZ19_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ19"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ19"/>
    <dbReference type="WBParaSite" id="SPAL_0001101500.1">
        <property type="protein sequence ID" value="SPAL_0001101500.1"/>
        <property type="gene ID" value="SPAL_0001101500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001101500.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="70351" checksum="D2D05670A4AE3221" modified="2015-12-09" version="1">MSVDCSDKIILNGVDVVNIDELSPSQNRALLKFIEANKDLLSVSDRPFDSSSERNAAGSRGSGRNSRFDDSQYRSNASGLNNDRYNTLDTSYSAPFPYSDRNSNYGTSQKRKEVSWSDAIDSLGNQQHPRSYSSLSRGNNNYLGGNSTSLDNFNKADRSRSYSPTVINNLSKNKKNFYKNSPENMAGYYGSQQTIPQTPQSMYARDRTISPLTNYASQIRESRAPPTIVNNPAAYDSHTSIIHDVKRATTPTRKPKEFDDSRFGGFGDRPGSGVELIPSKWHGGEIITDPSQIPKGLKTKKFYYSPIGDGTVAADGIELKKLPPDLTPKVEIIHQRTVERKGNDGHSGVKIYEKEWTEGGGSGYGGGSHLNSRYSSEPPAGFGDNLGSGPYGKDGDPFGKGGNDPFGNRGDPYGKGGDPFGKGGDPFGNKNSDPNNLNDPFGSLSNMVPARSNNASPYKSYPASESQFPTGRDSTGSSMFGDSTRSRRFEIKTDYMITNPRELIHQYATTTPTAVLDLTDAHDSSKTVTKSSYSATSSSYREESNTYSPYAPYHSHNPNLVGPKKFTQQLRDETLTSSQREANTHLNPLNEHDVQAQQRLDQIKRETVTRSARGFNDVDNLTEKMMHDLQTGYPNVPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ45</accession>
    <name>A0A0N5BZ45_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ45"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ45"/>
    <dbReference type="WBParaSite" id="SPAL_0001104100.1">
        <property type="protein sequence ID" value="SPAL_0001104100.1"/>
        <property type="gene ID" value="SPAL_0001104100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="265"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001104100.1"/>
        </source>
    </evidence>
    <sequence length="1214" mass="139887" checksum="001829590D7B34F1" modified="2015-12-09" version="1">NNLVMSDSPNNLLTSVEKECNTVFDKNECLESSQDDSDSDASLSDAPGLIYKSGKISNISVVIAIDSGSTFTSISDNLQYLLKMPDKEGSEVPIKLIEGMTAVKRVKGKRLLTIESNSIYLKHPLIFNSHHHNFDILLGRDMLKKYGAIVDHTDGAINWSVTVFQYGIDVNSNEESKTYALYTESVIVDQDKQKYLDEFIAAYDRHLREKFPSVFIVNDSQIVPTMVAEEQHFNFTEQNKNYKTYGLSYHNQSIALQLAKTWEDAGIIEEGEPDNGITHPVILIDKQKDSSDDNKNVDITSRYRLVCDFRCINEFTHKHCEISMNITNSNLINRLFVFCSKLDFKTAYGQIKLHPSNTRSFNITIGHKKFNYLTLPQGAKNSATLFKIVMMNLFQDLFEQQHLQWYHDDMLIMTHADSQSPLTIDDEIRKAQEHCDLLELVFQRMESKNVKVSQIKSQLFQKSVSYLGFTLTRTGWRPSIQSVNRILNRGRPDSRESLRRFLYASNYFSICIPNFSVIASSLYDLINTKSKKKFVMQTYHLDAYHKIARSLCDVNHKLYFGDPNADYIIRVDASSTGIGGSISQNLFDAETNTIREVPLGFVSFRLPKVVRRRSSTYLELKGIASVLEYYKFLLENCPGKIRILTDHKPLEKLRYTASMSKHVELLSHIDKFNCIFEYSPGKLHFMPDWLSRIENEKLLHDDESGDDEKGYDDSNEQFNSLTCLLVKHSRGRPRVLKEKNNEILIKRKVGRPKKGESSPTKQCHEKVNVTNKEKEHSDDELNIVELNEKNDMSNTEKNDDDNEIHITELNKKEKSSLYKILRSNILFSFDELKMEQEKDDNCQRAVKNKYFLNYNVRVNDNGIIQICKTNLEKGEACDDKNWKTLIPLSLAEKVIKMAHSQGHYSFIKTLSAINYFCYIPQPGKMIKKILNNCNTCFIRNSGHHHQPSNKTIDLSCYPFDRLSMDLITPRKLTKYVTTNIYLYKEGSEIIDTLIKNIFTKGALPSVIRTDGDGQFRGSHFTDAMKELGVKLELSTAYDSNSNAIVENKIKSVNKVIHSLTEDYPTTSFCQLLDLVSHFINNSRVIGMQMTPVEMMFGISPRTTLSNILDHNSTLKYIDRSDNLNEWLNSITMVRRILNDQYIQYRQNVNNKKKEKYDTFEVGDTFYFRRPRKHTFDKNYTPHVVLKDLRTKVLYKSGNKTLEASKAKIKKLHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0N2</accession>
    <name>A0A0N5C0N2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0N2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0N2"/>
    <dbReference type="WBParaSite" id="SPAL_0001156000.1">
        <property type="protein sequence ID" value="SPAL_0001156000.1"/>
        <property type="gene ID" value="SPAL_0001156000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001156000.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54133" checksum="D0CB6D0F17CEFC9F" modified="2015-12-09" version="1">MSEAPNFLLFEHALGYVLFRIKEFEDIGMALPQVQEAILDPKKFMSIINVEAFDPFKNTEAALDNCNAISEGICHPDLVTFLESNLPKKKSKVTLGCGDNRLAGSLVEQFPKMNVMFTGVVPEIIRGVRFHIEKLLKDIPHFSLAKAQLSLGHSYSRSKVKFDVHRVDNMVIQSIALLDTLDKDINLFAMRIREWYSYHFPELYKIVSEQTKFIKCANIIMDRKNYNDDTVAQLMEVLEDEAKVNEITDAVRTSMGMEISELDLLNITRFTSRVNSLLEYRAGLHQYIKDRMASCAPSLSALIGEQVGARLISHAGSLTNLAKYPASTIQILGAEKALFRALKTRSKTPKFGLIFHSSFIGKAAAKDKGKISRFLANKCSIASRIDCFSDVPVPTFGEKLREQVEERLKFFDVGEKPRKNLEVMEEAMSEAQPVIEKVLKKKRKAEKKARKAAAAANAADESMDTSAIAEESPKKKKKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C182</accession>
    <name>A0A0N5C182_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C182"/>
    <dbReference type="STRING" id="174720.A0A0N5C182"/>
    <dbReference type="WBParaSite" id="SPAL_0001176000.1">
        <property type="protein sequence ID" value="SPAL_0001176000.1"/>
        <property type="gene ID" value="SPAL_0001176000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF13">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895420" evidence="1">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="244"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="451"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001176000.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="64106" checksum="D743E8059DFF789B" modified="2015-12-09" version="1">MILFNKIIFLIFLLTFTYGSTRSSLKLELPKKCELSPLDLVFVVDMSGSIGKTNYYQSMESLSKMINESLEVGQSVSKSHVGMVLFDATAEIYFNLNKYTSNGAVENAINSAPYKGGGTNIYLGLKTAVEQVFGYDGDRKTDPNVLLLITDGQDGNEVGLKEINVEATNKNITIFAIGVGNAFNYTELLAATGNASRVFNATDYLNIENILESFCKDVQHNYPPSNYGPFDSSCSKNIQNLWIDMVFVVDSSKGVDKQGLLGIGGAIAGFVSTGFTLGKNNERYSRAGIVSMGTTGTILADLNKFTNSSSFIDGILSVPYHGDEKPNIYDGLKKADKILSSATGNPNRKQVVYLFSSETNIECDEGVEPSLDEDPCRLAAAMKEKGILIVTFALKYDGNNNVNLLTALGSECFNFFNDQTIIEDMINGALYANCFCPQPMIQFKNDRKCLKTAECIYVHEVPSTWSTAQMICPLDGTNSTLVNDFSIEKNEFLVEQLNSYNTYPYSIGLHDTDSNGNFKWDSNNDLGLYTNWDVNEPNYKNGNCVQINSKGKWFMTDCNDYNNAANYICEEPACDPDNFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1L0</accession>
    <name>A0A0N5C1L0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 25</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via cytoplasmic region) with ILK.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1L0"/>
    <dbReference type="STRING" id="174720.A0A0N5C1L0"/>
    <dbReference type="WBParaSite" id="SPAL_0001188400.1">
        <property type="protein sequence ID" value="SPAL_0001188400.1"/>
        <property type="gene ID" value="SPAL_0001188400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001188400.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24473" checksum="CB738E31AA3EB148" modified="2015-12-09" version="1">MVRYFTSTATNPPSLLYVGRDKEENELLIRWGWPEDVWFHVDKLSSAHVYVRLKEGQTMDDMPQELIEDCAALVKANSIQGCKMSSVDVVYTPWSNLKKTGDMVTGQVGFYSDKQVRRCKAEKRNDIVNRLNKTEVVEENVDFKAQREERDAKERQAKKKLERERKIREEEERKRKEKEKELRSYENVFVDDKMNTNKDGYDSDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C288</accession>
    <name>A0A0N5C288_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C288"/>
    <dbReference type="WBParaSite" id="SPAL_0001210000.1">
        <property type="protein sequence ID" value="SPAL_0001210000.1"/>
        <property type="gene ID" value="SPAL_0001210000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210000.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13817" checksum="7FD8937E4E24724E" modified="2015-12-09" version="1">MAREKTFTVDPEKPLKEVGIEMMKNLGFLGLDHLSKVTKGNLRKSPFGAFTPLGGHIPGFNKNIGDLQQHVHGGVLVIKSDLTGKSEDCGKADMNKTICRNLLKYLTKKYPEVKKCAVRDKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2K3</accession>
    <name>A0A0N5C2K3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2K3"/>
    <dbReference type="WBParaSite" id="SPAL_0001221300.1">
        <property type="protein sequence ID" value="SPAL_0001221300.1"/>
        <property type="gene ID" value="SPAL_0001221300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001221300.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14841" checksum="65388964625D9B3A" modified="2015-12-09" version="1">MDYLLNLDTAEPTNILEGQETVDINDLFLDESKAVDINKNMDVKTLMGQVMLTHDNWKAVTTKHRVVKGNFFKAPILPEEFYRRLSKTAQFTDSALYRATTHILQALGCCTHLVKKSIGILALDHLKSAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C332</accession>
    <name>A0A0N5C332_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C332"/>
    <dbReference type="WBParaSite" id="SPAL_0001238700.1">
        <property type="protein sequence ID" value="SPAL_0001238700.1"/>
        <property type="gene ID" value="SPAL_0001238700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895312" evidence="1">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001238700.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40752" checksum="034EBBF08926C378" modified="2015-12-09" version="1">MNNSILSYFILSFTFFNLNLADKCTYTVPTNGYTTTYEIECPPNTNTGGSGTNVPTQTQVYYDPTYYNRGYNNMNYQTLGSNTNNVVYYYTDSTGNNYQYTNTNNQACNCGTMNCQCTTYYYYPTGGSSSAQLRNRPRGLGLLTLPTGVADERTGPFVPGLYVAGDKPSLKPQTVEDIHLPGQTAHFSGRTKFDPFTQAVAAVYTEDLIDSWGFGYAVNGVNNYGLKVKENFDQFADVPLFGNNGGMQPFINSFVVGSEFDLKKIKDIAANVEVPILGLNEMFDFDGKLFVKGNANGVFQGYWDLPLTLSDPQERAAGSMKYLNYQADRHYHYGHTMPSMNLFLLDKEKIIERLTRNRANPAFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3S2</accession>
    <name>A0A0N5C3S2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3S2"/>
    <dbReference type="STRING" id="174720.A0A0N5C3S2"/>
    <dbReference type="WBParaSite" id="SPAL_0001261200.1">
        <property type="protein sequence ID" value="SPAL_0001261200.1"/>
        <property type="gene ID" value="SPAL_0001261200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001261200.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="65408" checksum="660A24E884A6DEAF" modified="2015-12-09" version="1">MSYDDIRKLSIYEDAFEEHPEEIKTFEIKETITETKIAFHHFMNNKFELAEMKLVKFSDKTIYHSMGLSSILFIKAMMTCTRKDLEVALESCKKTLLVIEKFRPSNGSFNLLSWVSNKQRSLSDEEIHAELCYAEILMLKGILTFFVDESLTSFIKGALKINSCHTIFRNCYKIINTEGWKDRDQMIREQFEAGARAGIGMFNLIISIMPPKICKLLEFCGFYGNKAFGMGELLKASEMTKTLRQPLVCLYLLSWNLIGTFVLENGNTDIDLCEKLLSPLIQDYPDGAIVLFLKGRYYLIRGDIDNAIHFYNRSIKVQNNFKQFHHICYWELLFAFAYLRQWSRAAHNTKILMDESKWSKCVYTYLMAILINAEKSVTKKDDTVNILLKKVPKLRLRIAGKSIPVEKFCEKKAIRYLRTGSLLLAHYEFLYFWHAFNILSSNCKLITLILEDITNVSGKVVENDEVDVDDRCLYYFLFGVCNRLLKNYNEAEDALNYILSRESQLTDHTYLAPNATYELALLKNSTGNIELSKELLKKALIYHGYLLETRLHLKIHNMESKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3Y9</accession>
    <name>A0A0N5C3Y9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HIG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3Y9"/>
    <dbReference type="STRING" id="174720.A0A0N5C3Y9"/>
    <dbReference type="WBParaSite" id="SPAL_0001267300.1">
        <property type="protein sequence ID" value="SPAL_0001267300.1"/>
        <property type="gene ID" value="SPAL_0001267300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF17">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001267300.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14396" checksum="2CF584DDF4F2B438" modified="2015-12-09" version="1">MNSFISGMLFRVAKCSTSHPESEGNHGGKSHGFVKTPGVPAMPLDIGFKSGKETQGSRGNVASEGFLSNPLVPIGMGLTCLALLGMFKNSMSGNKMGAQKFMRYRIYAQFGTVMAMVAGLAYTGSNIAEERKHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4W2</accession>
    <name>A0A0N5C4W2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4W2"/>
    <dbReference type="WBParaSite" id="SPAL_0001299100.1">
        <property type="protein sequence ID" value="SPAL_0001299100.1"/>
        <property type="gene ID" value="SPAL_0001299100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001299100.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9601" checksum="1D99190634E4237C" modified="2015-12-09" version="1">MGEVSNIKPLKGFPQKDPQYPENARRVIYSFVVTDLADASQIQIAAYDTYAQKLNGRFYKGQRYIFSGGRSCFGGRHSANPTMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C525</accession>
    <name>A0A0N5C525_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPM_phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C525"/>
    <dbReference type="STRING" id="174720.A0A0N5C525"/>
    <dbReference type="WBParaSite" id="SPAL_0001305000.1">
        <property type="protein sequence ID" value="SPAL_0001305000.1"/>
        <property type="gene ID" value="SPAL_0001305000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001305000.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37541" checksum="37D2F2E956C70704" modified="2015-12-09" version="1">MASKRVISIYITEQFYRHLDGTIQKFRSVKKYIQETSRTTLDKMPKIKSSTILRPKTRSSSSFQQGTTISSLVDTFFEYWNFLIVYIDMLTRNIVFCKTTAGRMVGFVAFCFILPYIIPYNFLASKSTTSKYTLTNLQLATEKLNPLLSSVFSLQNEAHYYLLELARDRIRKRTHGLPIILTFIHEKRDKSAKLFITQYANITAFHGKNMVSEMESKKFGADKEFLKKSLEKELKSNNVVVLWNIQDLESDLPLIIHSEADIHTTSNKNAFWILTVEVDTINNDCYLILDRSLKEAWIGNHEMLNNDQILPILSRISSFPICLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5S3</accession>
    <name>A0A0N5C5S3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5S3"/>
    <dbReference type="STRING" id="174720.A0A0N5C5S3"/>
    <dbReference type="WBParaSite" id="SPAL_0001330000.1">
        <property type="protein sequence ID" value="SPAL_0001330000.1"/>
        <property type="gene ID" value="SPAL_0001330000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001330000.1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125492" checksum="777B3D00B3802F19" modified="2015-12-09" version="1">MRRGINLYPIQEESEPLVEDSLGTYYKDNGTRSHYIYCANYLGHCIQRNYAPPVVNNFCGCHEAYQNNSQYDTHPNICYDSQQNNMQRSPNVNQHMVNSNEHNTMIGNFYDVSSDGNYDNIQDNNHRNNQFTALNNSLFTDNNSELGYDDNISIRGTRYNKQHKRLQSVLSNESISNGILSKSQDIKNRVSNVGTEITNNTIIRNIRNISDEFTKQLSIPETDRYELGSHFWKDNFEGRFLPTLSDTQSECDVFQDVDKDLTPSEPIEHECFYDFMEDGGFNSGESKETICCSEVPVRSTENNRGNSSYGINLDLPAIDVDLNVVDHDSDRANSIIRYESIGNHYDCYGGTNFKELNAYDQYYSNNISTTENYQKIPFDYIVRSVGGDDSHNNSVQSEYFNSLREGKKVSQSIKQPSECQIEVVDANNISGVLKHDNFSKQSVTINNFESDDKTLEVGIQYNANIISHNNGKSKCLGSRKRQQKKIANLQPDSDENSSDPEQANKRLKVHINIRCYPNSTDISISTKNVPISDGSEHEHVFCRWEACDYYFTNIDDLYQHVCSEHEARGRNFYCQWKSCLAGNKKKSSSFVSLDDFLEHMYDHVNVKQFFCGNDDCRSPDGFYTKKELEDHVKKCYCVRKVFICRESLCTATFTCGNSRLCHEKKIHIKKNISVYLCPIYNCAKTFPDPSGYQRHVRSSHGLLSYEMIKHMKHTICEKGNTKKLFGLLTKRVASHLTEEILQFPPSERKDVKKDLLLLYDCLDICVHKDYSSMKNILEKMVADMKDRKIRTSINAYINKYVARKKPVDGVIVIGNSFILQLSDMIFKNLEILRYPILSISKDDVEELRKAELLLTKQYIYMKLEENEKNRQNKLRSLKRTDELDNSFNKMPDQLSEDEKYVEEYIYIEEEFSDFGKPINLPNFNINKLSGLSLTSNPYNKLYPEKTRNGRNSPTLRDHKTPELCPAYLMRVLINFKKYLKSSKYESNLSYKNKVALFTKIPEKFHDPSKEKKTRNNKKKGDKKEDNKEKGDMDDYNNETGGKNDNEGNMEKVDINESTNITTYDKKGKSIRKESTYMVMWGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C629</accession>
    <name>A0A0N5C629_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1767 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C629"/>
    <dbReference type="WBParaSite" id="SPAL_0001340400.1">
        <property type="protein sequence ID" value="SPAL_0001340400.1"/>
        <property type="gene ID" value="SPAL_0001340400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340400.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49001" checksum="2B625A92A79C501C" modified="2015-12-09" version="1">MKPNDVSQLEVFLDISKEPQEQDLPQLSNSHWKGVVAAFKHKEIFAHWELQDLQWEKIHLNLLDKLSKENVFLRLDAINRMPVTGTFLEKLQEIILVTEKLFVGEESKFLIINKFANSLPVEIKEKNMAPQNNSIESWKEYAKILDDNMKITLKNIDHSFSKPIRTSTPLSCRSTGQHSTEVSTGIDTLDASEISQISTKASTGIEIISSNSFATPILSNETAITSANSQDESSKKRFSTATHSNSTNLTTNSNDGSVIKLYSVKPIGNFKIIDAGCSQEIVEKILSPKSYESTVAFQMFKKLEHYGYSYIVEHNTGMNGNTRISKAGGQVNVFQQGVESFFVHVTKSKSKSLLIITNQLDVFNEFKKFNTGFDNLSHTGQTSCKKAMVGAQDVQVSVMFIDKSIHIPLMTKVGGEIEKALKENVGYKDIPVTYKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6D9</accession>
    <name>A0A0N5C6D9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6D9"/>
    <dbReference type="STRING" id="174720.A0A0N5C6D9"/>
    <dbReference type="WBParaSite" id="SPAL_0001350900.1">
        <property type="protein sequence ID" value="SPAL_0001350900.1"/>
        <property type="gene ID" value="SPAL_0001350900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001350900.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15628" checksum="E6FC68A266919BD3" modified="2015-12-09" version="1">MVKIMKSGKVVLVLRGRFAGRKAVVVKTYDDGSNERPYGHALVAGIDKYPLKVTKKMGKKKVASRSKVRPFLKVISYSHVIPTRYSLESEFDKNLVNKDAVKEPNTKRKALASIKKEFEDKYKTGKNKWFFTKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C718</accession>
    <name>A0A0N5C718_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C718"/>
    <dbReference type="STRING" id="174720.A0A0N5C718"/>
    <dbReference type="WBParaSite" id="SPAL_0001373300.1">
        <property type="protein sequence ID" value="SPAL_0001373300.1"/>
        <property type="gene ID" value="SPAL_0001373300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895552" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="601"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="913"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1087"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001373300.1"/>
        </source>
    </evidence>
    <sequence length="1186" mass="138281" checksum="D7C53684288A03F5" modified="2015-12-09" version="1">MLLKLYLLGAALAFMPLSTQPDEVHRMDLFPNIPEDVNGTTFPFDIKVINSSDIVLVKCPNAGYRHTSTNDKFSNSMDILSLENIKIQYAKLLSVWFPLLRNASGSTHINCGEVTIKSNGIPPKSLDWTYNVNWNNSLTDIVRETLTYVDSTVPKSSIDCINDEDRTVIFTKNKENDVVLKVDPNMVEKPYVNQLFYYFVKPDEIDKELFKKPCAILKGFRSCPSFALQKEGFSSLVISNSNMTIVEVSGKTEKINVILKQKNDIEYYRGEKISLSKMRYKEGGHEEIKNSNITLTSKFSIEGYDLVKLTYICPNGGNPTMISQKYYFAPTSKDLKIKEETVTYTNNDTSTKPNCPLFYLNIGYLYKFKHNETEKDYSNLAPIGTIKEISSKTESHIFFKGIEDPHLTIKCFYKTPDGNITTITEFIDKDMVAAIQEEERRRVLEEERQRNQTQQSQIDAFRKDIEKTEEKGKKIEEEKKKIEEKLQKSNMSLFQKLSDKVGKGNAIFLVAALILFILIILAVLIVFVYKKWLSPYLIMLKQKRKYPNVYVFWDTLTSQPFDNYCKAIKEKKYLSNKVLNQIVVKKMEGGEEVDVGVSHLFDQTLVKCYRRFPRKIKAHYIYTDIEKRKYILSDGLTKDTQSTFWQMVYEEDIGTIVAIIYDTKSLDVDEYPDDIYWKWKTKKRVFGKVIVTRLEEIKVNALFVTGQKILLEKDGGETKNLEIYHVSNWKENDIPQSDLQFVNMYQEIIKDSQKKNILIHSPEGTGARVYMFTYFACIYDALKTDNDTDCPLKIIKMMREQRYGGNIVPYEFAYVIKALVTNFFNNKILVDFSSRRADFYSSYDTYFYDYLRRQAKMDENVKKFLDFVNIVDEGKIYEYKSVFDTLGRMDPDILPEYSKRFQNAVKNHKEGKDKKRFRYSDIPCIDANGITINGKPEDDKESFIHANKFEYKTVNGTRKLILCQAPTEDTRDDMLDMILRYKVSLIVILVKPEEAIGPQKKWVPYYPTEHYELDTPNFTLLRIMLNKLDENFIVQSRYQVRSKKTNEAVAFDVLHYQGWPDTSIPSEHKSVYGLYKKIVSLRTDDYVVIHCSAGIGRTGTLALIMYLIDTINYFPTFDPITRLKCLREHRYLAVQKHNQFVFALLVVFEHYKKEIDEMDAEAYEKFMTMAEKLFNKEKKRQDKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7U8</accession>
    <name>A0A0N5C7U8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GLTP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7U8"/>
    <dbReference type="WBParaSite" id="SPAL_0001401000.1">
        <property type="protein sequence ID" value="SPAL_0001401000.1"/>
        <property type="gene ID" value="SPAL_0001401000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001401000.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49070" checksum="15F7C3A20E9013C9" modified="2015-12-09" version="1">MLVNGQTDDPLFEGLKFVYVCKKHNIDKYDSWMLKDLTIDKVFEEAGKENKEKSLSEKLEILKNIKIIKDYQTTLLYIKKISSCLFEKDEATIISSITFTEKVPKKYHSHCPATFKDDLFIKWSKMIDEKEKEMFSPIHHSTPNTSECSTASNTSLRILNSSKIDDKLPQTNIVLKQHNLNLHSSVNKPMEISKLINHQPHLALTEIDNQHTIMVLDDKNNQTITSFMNNGNLINSVNDINLNNYNSSSGKIEITDIKGFEEIDKLEKNNDKPTLSFNLVNVDNAFGYVIIRRCNQKTFETRSKCHGKTKEDLATTCLLLDVIKIVIEINDDVNIHIKNKKLLEIFKNVDTTGKFCSTSVAAKEEYAKAYVLWHEFRHKLIFYVISGEMETTFTMLLNSYITKMKHNWVNEKKDLTTNEIEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C849</accession>
    <name>A0A0N5C849_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4342 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C849"/>
    <dbReference type="WBParaSite" id="SPAL_0001410500.1">
        <property type="protein sequence ID" value="SPAL_0001410500.1"/>
        <property type="gene ID" value="SPAL_0001410500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001410500.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8534" checksum="0433F3F36F40BF2D" modified="2015-12-09" version="1">MVFNFIRAFLNREEVIRKLSNSYPIRMAARVIVRTGFKAIDVVQNSVTGKEIIRRKKIFLETFKEEFKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C868</accession>
    <name>A0A0N5C868_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF1_GNE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C868"/>
    <dbReference type="STRING" id="174720.A0A0N5C868"/>
    <dbReference type="WBParaSite" id="SPAL_0001412300.1">
        <property type="protein sequence ID" value="SPAL_0001412300.1"/>
        <property type="gene ID" value="SPAL_0001412300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="127"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001412300.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23836" checksum="43705A8ACADC95C0" modified="2015-12-09" version="1">MAFSKDVINATSAADLAAFNAYLGDFPYAGGYTVSSKDFALFKLFKTAPCSKAYEHLSRWYKNVASFTEEEQKSFGGPSTSSANKPDDEDFDLFDSEEEDEEQAKIVQERLKAYNEKKSKKPGPIAKSNIIYDVKPWDDSIKISEIEEGIRKIEKDGLVWGAAKILPVAFGIQKLQICCVVEDDKVSSDWLEEQITDMEDLVQSVDVVAFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8S0</accession>
    <name>A0A0N5C8S0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glyco_transf_64 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8S0"/>
    <dbReference type="STRING" id="174720.A0A0N5C8S0"/>
    <dbReference type="WBParaSite" id="SPAL_0001431100.2">
        <property type="protein sequence ID" value="SPAL_0001431100.2"/>
        <property type="gene ID" value="SPAL_0001431100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="7">
        <location>
            <begin position="165"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001431100.2"/>
        </source>
    </evidence>
    <sequence length="406" mass="48466" checksum="8C50EAE615AFAAFF" modified="2015-12-09" version="1">MSKEEKNKTLVELQNKDLILKFDNFCKILSYSQNFESLVILLIATNCVPLINKDWIKNLPLIDNDHDWEKGILLVENTDFNNEKFLKNIEILTSDINQMKEYGKRLISWNFIQLSSISFNIIYFLEKFFTGINIERTIQAIPLYKEDEILFEKERLRKKIISNKYTVITLTYQNNQKLNLSLRQYDSIPFVDKVIIVWNNEDTKFMLEKNRWYKSRVPVFFVKTKFNSMNNRYLPYDIIKTECIFFLDEDIRITEKLLMKTFNFWKMNKNVIVGYYARYTEKGVKSSYVLTKTKSYNLILLGLSLIHRRYIYSYSYKMSSKIRNFVDETLNCDDIAFNFMVALFTNKPNILFTKGVDLSRCKKCSHHTGLYFRPDHLTTRGKCIDMFTNLYGMNPLIENEYYSGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8X8</accession>
    <name>A0A0N5C8X8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8X8"/>
    <dbReference type="STRING" id="174720.A0A0N5C8X8"/>
    <dbReference type="WBParaSite" id="SPAL_0001436100.1">
        <property type="protein sequence ID" value="SPAL_0001436100.1"/>
        <property type="gene ID" value="SPAL_0001436100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001436100.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23589" checksum="8381AE610A5E8D58" modified="2015-12-09" version="1">MMDVNEDCDIRDKPGFVSRFFTSIGVKYQYYLDRLTPYTGIRWGMALFTLLFFGYRIFALQGFYLICYALFIYYLNMFLAFLTPKIDPALDFDSEDDEEMPSLPNKNNEEFRPFIRRLPEFKFWYSFMKSTLIAIGCTFFEAFDIPVFWPILVVYFLMLTCITMKRQIMHMIRYRYIPFTTGKPKPVGREDTGAVIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Y4</accession>
    <name>A0A0N5C8Y4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Y4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8Y4"/>
    <dbReference type="WBParaSite" id="SPAL_0001436700.1">
        <property type="protein sequence ID" value="SPAL_0001436700.1"/>
        <property type="gene ID" value="SPAL_0001436700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="13">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="14">
        <location>
            <begin position="154"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001436700.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="47563" checksum="4AC89855F10F6DD8" modified="2015-12-09" version="1">MEIGGNISVLNNGYVAAGFSSDSNMGDDAVTECSSFNGAPFSGRLSYNPAKSNRVVDVSKDANNEDMLITKMVSLTNGILYCSLNQSMSPPSSFANSNEVLKGTTQTYYIFLASGSTNGNNLRIHSLDTNSQLFPYISPQSVEVKRYKRDGTGQVTLGGSTNTITNATNSNALNDSAAAYQKYRRLLKQIHGILMILGWSIFLTTGILAARYLKGNWPNTKICGLLIWFHLHRTLNIIGIGATIASFAIIFVAEEWRWAGPSIYKTDEQNQSWGSVHSILGLLACCIAWAQPIGAVFRCSPDSTFRIIFRLLHGFFGILAWLGALAATMIAIVHFKSLYTNSTAALALYITYIVATGIVILANEFLTIRLWLITRKAVHSSEIEMVQVKNGKTHVERSDNVKKFYNLRYPVFLFFLFVSIGTCVAICCLIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9L0</accession>
    <name>A0A0N5C9L0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9L0"/>
    <dbReference type="WBParaSite" id="SPAL_0001459100.1">
        <property type="protein sequence ID" value="SPAL_0001459100.1"/>
        <property type="gene ID" value="SPAL_0001459100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001459100.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19528" checksum="F5E185F47C5E635C" modified="2015-12-09" version="1">MEKQIEFLPNLNHIISDPFHDLMHGIVGVVMYPLLIIVQIITDILNNELCDFILDESKQLGYYEKICTVFKPSMIVVPQRYDLTNFQKKVKLSVSGTQSLYILHSFYIVVCKIIEEKKDILDSISKMLQIKSLIECLLNLCYMTMDHEISVHEAIKITTTNVDHFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAU4</accession>
    <name>A0A0N5CAU4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAT complex subunit CCDC47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 47</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC47 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAU4"/>
    <dbReference type="STRING" id="174720.A0A0N5CAU4"/>
    <dbReference type="WBParaSite" id="SPAL_0001501300.1">
        <property type="protein sequence ID" value="SPAL_0001501300.1"/>
        <property type="gene ID" value="SPAL_0001501300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895878" description="PAT complex subunit CCDC47" evidence="10">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001501300.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52866" checksum="C156D3C6D66A6091" modified="2015-12-09" version="1">MKYSFIFIFLLLVFSFKSAFSDVYDNIEDNEFAEFEESFDDKVSIEESTPLPSVKKEKEIVNDFLEDDFTHIDDNNNNIEVNDEERLEDFDKVNANEKSSNPPKPLKFADVPTHLKSNWKTYQVEVLMMIILFIYTVNFIIGMSRNSSIAHKWFEVTRPFLETKFALVGDDGVSEEPVGGVMIKQTECSYLVYCTGRLGCTGTMYEIKLIKRQDLIGIVQNIIGPKSDKVIMRTDLIKGEIEPIIFCIGNKKSVAKQVKESEDLSAFTSDRKNADKFGLSRNFAIYTELNEVILSLMDTYINECFKKYEKYIDYIHVSDQYTGPTLQEGEVYTKMPDPEVICTVSLNILDQIDDPELNNELMSFIFNFIEKLKKVKLSREGKTKADKNRAAVEAKFLKMTHQQRQEAAQLKKDAKIKERKERIMNEEDPVLQRKLQKAEEKREAKAKAPKMKTIKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBN8</accession>
    <name>A0A0N5CBN8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBN8"/>
    <dbReference type="WBParaSite" id="SPAL_0001530300.1">
        <property type="protein sequence ID" value="SPAL_0001530300.1"/>
        <property type="gene ID" value="SPAL_0001530300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="SF4 helicase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001530300.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23042" checksum="700210CB13A6B527" modified="2015-12-09" version="1">MDENEANLISLPDNFKVPIFKQLDWKTLKKLKSVCRDFYFVIERNIRRLARPKILSLLLDCDESGIPGACYTIEDPESQSFEDLTNDVKVELVNNSKKLEGFAGWIRFDPLNDYLGGLRPSELTLLTGGIGYGKTTFICEYALDLCTRGVRTLMCSFEMNEEKIMRWMALQYSLLPLYKAEHHSRIDVNLERFKRSNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBT7</accession>
    <name>A0A0N5CBT7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBT7"/>
    <dbReference type="WBParaSite" id="SPAL_0001535100.1">
        <property type="protein sequence ID" value="SPAL_0001535100.1"/>
        <property type="gene ID" value="SPAL_0001535100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001535100.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17454" checksum="6A9102AE50E99DF4" modified="2015-12-09" version="1">MDINNNNIKAQERKNTLLVSKESTDEIGEFDELFKLFLRNRKMVKGSSNSPANDKKKTIKLPKILSKLQKRNNDKISHEKKNEKSRCENENDNLKPVTEKKATLSVPQPIKNVCPKMPDEIFEIAEESCFVSKYQIIPNRRVSMACKPDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC88</accession>
    <name>A0A0N5CC88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC88"/>
    <dbReference type="STRING" id="174720.A0A0N5CC88"/>
    <dbReference type="WBParaSite" id="SPAL_0001549700.1">
        <property type="protein sequence ID" value="SPAL_0001549700.1"/>
        <property type="gene ID" value="SPAL_0001549700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001549700.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="57738" checksum="4AC4670CA76EDA82" modified="2015-12-09" version="1">MTSPNGDEEYTPEIPKSLPKKIKITNNNRELSIQLDLILRNGAFHQYIGGEDQTNSQPIDVKTISANGLKVIKDVEDTLVKKENYKNVIRKTKFIEFSPSLNCNVIIYSTYMMSLHKYKQVYKYLPKSNEQYIYFKKMLSALEFLHNNGYIHGFLNLTSYHISLIDTEKKIVGNILISDFDLLTRSKKDKSFDKLGNNNGSLKAIYEKRLQRSCNNTPFCALKQYTGDKISMKNDIESWYYICIFLMEEIPDWEKIIENEDKMFVMKQSMRQPTYSTYNRTCIRFTEIIQLLDKMNNETLDYKLIKKKIINAQKRFEENESKQKNDSLSDASDFVKLASISRTRKKPFTQESLELLQKEIEKDELKNKNDLPNGKKETEKKENEKKGKDNDKKGKETETIKKSNTQIEVTGSTVHEPMELDKTTYNQKVTSENDTATKKKNIRSVEYLVEMNKKVASTNNETKSVFQEKKNPENSNFLSSVKKKFKTLFKKTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD88</accession>
    <name>A0A0N5CD88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD88"/>
    <dbReference type="STRING" id="174720.A0A0N5CD88"/>
    <dbReference type="WBParaSite" id="SPAL_0001583300.1">
        <property type="protein sequence ID" value="SPAL_0001583300.1"/>
        <property type="gene ID" value="SPAL_0001583300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001583300.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="32456" checksum="7D3BF8956B1ADDE8" modified="2015-12-09" version="1">MEFTIKRHLAVATGLSVVSFSLLFIGVPMILNDIANFENHIIHSREAYISLSNGMWEELLSQNVIIRKARASAAIKRQAYDSAGVEAAGAKKKANECPAGPPGPKGPPGEKGEDGSPGVDGINGVQHGSSDAEFGSGYEGDVAAVQSCASCPQGPPGLPGYKGKRGPRGLKGEKGAPGVPGRDGEVGDPGPEGEPGLPGNPGDQGAVGEPGNDAQGYAKGSPGPKGPPGPAGEIGEEGMQGERGDDGLPGAVGSPGESGPPGNPGKDGMPGLKGPMGTNGIDAEYCPCPDRSKGGSKQNVGVEGGYSAGFSENVSPPASAPYKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDB0</accession>
    <name>A0A0N5CDB0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDB0"/>
    <dbReference type="WBParaSite" id="SPAL_0001585500.1">
        <property type="protein sequence ID" value="SPAL_0001585500.1"/>
        <property type="gene ID" value="SPAL_0001585500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001585500.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18967" checksum="0D8DDEC17671087D" modified="2015-12-09" version="1">MIFAEKEPGKPLNGSYTFAVLVIVIFANLLLFIVIRTLLNLENDMDQPYIDEPFRTYLQYFLLYFSLSFCFGCWCCCCGGGLFLTSLKKIKFCHVKQNDALDFAAIHRLYNRIKHVKPNTDFVKKFRRKNEDDSSSEDNETDLNVASLEEVVVDGKKQNKILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDQ4</accession>
    <name>A0A0N5CDQ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ca2+-binding actin-bundling protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDQ4"/>
    <dbReference type="STRING" id="174720.A0A0N5CDQ4"/>
    <dbReference type="WBParaSite" id="SPAL_0001599700.1">
        <property type="protein sequence ID" value="SPAL_0001599700.1"/>
        <property type="gene ID" value="SPAL_0001599700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21292">
        <property type="entry name" value="CH_PLS_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21295">
        <property type="entry name" value="CH_PLS_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000066">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="112"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="256"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="381"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="504"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001599700.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="69869" checksum="7276817F5BB154BB" modified="2015-12-09" version="1">MLTKEQIAEVSREFPSVTPEGSGYIKCDEVKDALKLLGIDLPGYQIRELLTRFNGSGELKYKDFEKLYDELDEKKNSFANSWKTGINNAQGAYKVHGLAEHGGDEIIHTIRVEEEVAYSNWINSNLSDDKDLSKLLPVNAESHELYTKINDGLIICKLINLAVPDTIDERVINKKNLNTYTKLENLTLCLMSAQAIGCNIVNIDADDLSKGKQHLVLGLLWQIIRIGLFNQIDLVNVPGLFRLLKDDETLDDLRKLSPEEILLRWVNYHLEKAGCHRRLQNFTTDVIDSEIYTHLINQIAPPGSNVTLQPLSVVGNVPRAEAMLIQANKIGCREFVTPNDVANGVYKLNLAFVANLFNKHPNLPEPGADEIDQLENVIEETREEKTYRNWMNSMGVKPFVNWLYSDLQDGLVIFQLYDIIKPGIVNWKCVVQVFRKLQQMMDKISNCNYAVDLGRQLKFSLVGIQGKDLYDGNTTLTLALVWQLMRAYTLTILSKCTNSNDGTLVADKEIIAWVNKKLSDSGKSTSIRSFQDPSISDGKVVIDLIESISPGTINYDILKNGDASLKLENAKYAISSGRKIGAKIYALPEDIVEVKPKMVMTVFACLMARDYMPKFAVQDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF95</accession>
    <name>A0A0N5CF95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mediator complex subunit 24</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF95"/>
    <dbReference type="STRING" id="174720.A0A0N5CF95"/>
    <dbReference type="WBParaSite" id="SPAL_0001653400.1">
        <property type="protein sequence ID" value="SPAL_0001653400.1"/>
        <property type="gene ID" value="SPAL_0001653400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001653400.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55417" checksum="FE1C36961264E0E4" modified="2015-12-09" version="1">MVKFCQLRHLYCKFPGTFNVSYSYIYEQLWIPHFIKWRSSEFEKKQPMMWLHSLPNVEAQEIVARYSVDYLLRSYKRVEHEFKAPEEISRYLKTLSVIKSFILNYLFKVKKYKQIIDKIYSIESIYSRTEILKSPKYFLESPKDSDDFMNELISTYGVSDWIRLLEIAKITRMDSVLALKHLLNACLKSSQINQASAILFTVSLDSDSLSREMLSMIKVVLDGIFLKIHESSAERSFNLSSCVNMLMLALKVFIAEADPLDVCNFGDLLEFSKYHKFLNIIKDMVDSTKLYEPMDDTTEAISTSDVFFKKDIPWEVHPLAHLLIKPFKVQYNSTTNRRSKPFTRSCLQLPMNGENNIVALLFVAGSIVENVESDVLKTRDYIDGWKDIFNQLLMDGQFYDVLNLVEIYNTLQISKVEDIGIRQFIKHATIGLLEKILLIPDCDLEFAASVINSVPESDVSSILQEIRNCFKANSNPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFU8</accession>
    <name>A0A0N5CFU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI/MSF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFU8"/>
    <dbReference type="STRING" id="174720.A0A0N5CFU8"/>
    <dbReference type="WBParaSite" id="SPAL_0001673100.1">
        <property type="protein sequence ID" value="SPAL_0001673100.1"/>
        <property type="gene ID" value="SPAL_0001673100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001673100.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20202" checksum="5AB7916A056FA195" modified="2015-12-09" version="1">MKFFTEEYIFDHPWHTVVTAAWRKYPNPLNGNVTGIDVLSHKVENSILKSERILQSQFDIPTWTSKLIGFSGTQYSHEYTEIDVDNRQMSLLTRNLSASRFVKIDEKLTYQPHSTEPNKTVLKQEVSVSVNLPAFADTCEKAFLRVYSKNAKVGKKGLEWVVMNLLQDNNNYQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFW5</accession>
    <name>A0A0N5CFW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFW5"/>
    <dbReference type="STRING" id="174720.A0A0N5CFW5"/>
    <dbReference type="WBParaSite" id="SPAL_0001674700.1">
        <property type="protein sequence ID" value="SPAL_0001674700.1"/>
        <property type="gene ID" value="SPAL_0001674700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001674700.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14845" checksum="3214B332496CC4F1" modified="2015-12-09" version="1">TIKETKIKMMEQKKALLARNQQLKSRIAHLKNEIKNRKVKTVSCISNISSLSTTTTTLSIAGSSSSTSLPIICYHSLIFEPKQTTKSPIKQYPEISQTNIIVNKQYSYDPFKDGLIAALPFTYPYNNGAMSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG49</accession>
    <name>A0A0N5CG49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG49"/>
    <dbReference type="WBParaSite" id="SPAL_0001682800.1">
        <property type="protein sequence ID" value="SPAL_0001682800.1"/>
        <property type="gene ID" value="SPAL_0001682800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895826" evidence="1">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001682800.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21196" checksum="96BB0B86B198AD71" modified="2015-12-09" version="1">MVYFKIFLNTIIFLIGIVNLTHPNAAEHLFRSKSVTKVRRVRSDGGFDPLNAHGGVFRKLDLSKDELRLISEYHALTEYGKIIDLLESKILDSEDMRSKEKINLLKIIHRMRPPKSVKHLLTKNDKHKMKHHYHKQEIGQAMDIVLRRLDEQDPSTRREIVDYFGLGKQDPKNKETRSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHM5</accession>
    <name>A0A0N5CHM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHM5"/>
    <dbReference type="STRING" id="174720.A0A0N5CHM5"/>
    <dbReference type="WBParaSite" id="SPAL_0001733900.1">
        <property type="protein sequence ID" value="SPAL_0001733900.1"/>
        <property type="gene ID" value="SPAL_0001733900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001733900.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30166" checksum="4641C052E10469E9" modified="2015-12-09" version="1">MVKKLYLTIYIYILGKEKPQIVIDAGMHAREWVTHSSILFIVDHLVKNVEKYKEILEKVDIIIFPVLNPDGYVYSRVGDRMWRGNRNLNDNKICAVDLNRNYPFSWKESDGTCQTYPGTYGLSEAESMYHSFYMDKFKHLIKGYITLHSYGRLILLPWSHTLKTDAPYYDEMLTLGNKMKEELKSKKNVDYTVGSSSNVLYACHGTSSDYAKSLGIKYVYVVELSPESSSNGFIVNEDQITTIGEEALIIFDVMLHQVHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI68</accession>
    <name>A0A0N5CI68_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SH3b domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI68"/>
    <dbReference type="WBParaSite" id="SPAL_0001752700.1">
        <property type="protein sequence ID" value="SPAL_0001752700.1"/>
        <property type="gene ID" value="SPAL_0001752700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001752700.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11098" checksum="CE1069D0C0BD7521" modified="2015-12-09" version="1">RYDEDSYEVTRCGNDDKLNVTDKPLGDLEKKSPLKKLKVGDRVIIRNHTSGKWDVIYSGGNDNAYIVKSLLKNAAYVVKEKKRGRPKKVHLQDIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W9</accession>
    <name>A0A0N5B2W9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate receptor-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B2W9"/>
    <dbReference type="WBParaSite" id="SPAL_0000042100.1">
        <property type="protein sequence ID" value="SPAL_0000042100.1"/>
        <property type="gene ID" value="SPAL_0000042100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="200"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="465"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="719"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="815"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="918"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1332"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000042100.1"/>
        </source>
    </evidence>
    <sequence length="1435" mass="159126" checksum="412A0CD4F398993A" modified="2015-12-09" version="1">MSIKQNDSTVTCCGIQFKKRTVKPINFTYNTGKPPKPFHAEKNLLPNKEFLKYKTNPLGNCKKGQLFLKNSRHFGNLEIAGLTLCQEKCNNSIYSPLIFTHTPEERYSSLIELEKQIKLLEGNTLTGYIKSFNKSNDDLSFDPPTSGTPMLPPSTTHQRDGTKFYSSLTNLEYYNKNHYDGEKGNLSKKIHGNSLTGSYIAKLTRTSDLHLGLGITGGADRALPPIISYIRPGFVAHRSDQLRVGEKLISVDGKNVSDLTHGEILTLIRTCGDSVMLEVSYDLNDPIFERNPNAINKCTEITLSKESNSFGLTLRGGSYGPDPKKARPITIVGVRPGSSAHIHGRLFVRDRILSVNGIDVFSCNLHTAYKILQESGDNVTLTIEYDVTICESRKHSTGPMFVDLNKNSCCADLGIKLAICTEEEYERSNFGTTCGIHLAGDKNSILSPLLKKKGTKMDNNISSTGLSLMKRKLIFIKEIIPASIADRSGALEVGDRILAIDDIQLEHTTLGEAEQLLKGQRETIRITFIPNHLLLKNKKDTKRMFTKKKEAEYSDNNGFLLKSRHSFYQRSAKSKKKQEDYMTTSISPVIGEARIVPMTNKSNLSYSSKDIYHESKGQQKFVSSNNLIGSKYIENGRVSLRDSQAQTTNYTSRAKSFDRSYLIANPSYNNMKITKSLVNNSSINGCFSGVPTSKVCHVETQKVTLTAPLASSALYKGYGISLHKYDMETSFTDDQTGIGENLGAIYISNIEKNSPADKCERLQIGDRVLAINDWFTMNGTIEEANHIIKNTKGSITLLVEFDVIEAPLSLSGMLSVKLTKRGNGVGIKCKSKGEYEGKKGEPLIVNEIIQGSPAYRCGSIHVGDRIVSIDDIPLSTCTVAEGIRLLHRCGDVIHLLIQKNHRIMEKQKEEGNCRYIYDIVLNRRGNPLGITIASNGETGEPIVITQIARGGVAEVTNTLHPGDQIIAINGESVEGMNVRNAMRILQMAKETVHLRIVSRHPKHAINVQLVDKQLINYSNNNNVVTSPGVEDPTSLMYTSLPPTSLSNYTNYLTNSQGGTSHNDTSSERSDKVGTPIQSIDSAVESLDDSPDGSGKRNNNHNDGYITSNKLQLQSLSSVLNNSKKETTTDYDGSDIPPMLNLDAKRQSSYMRKLYNTNEDIIIKTPISLPDNYIKKECCNCNEKKKKNERKRSSTEKSNPHWMSILEALETSGEEEMLKKLEETILSGDIDEPDKNYQHNIYIAKQNTNLTNHSIPSINQPVGILKNPLVKRDYCSQQSPTTSTCSSHEKTPIPSLGLFNICDDITSHRNKQQDTSTNLVFKNSELVQTTIHHFHLERDPISNSFGFSVSDGVGENPGIFVSQIKKGSPADTVLKPFDKILKINNSHVGYLDCDLALPLLAMEVLELVIQRDTPVEPCDDESCKSPISCVVKDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B355</accession>
    <name>A0A0N5B355_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B355"/>
    <dbReference type="WBParaSite" id="SPAL_0000050600.1">
        <property type="protein sequence ID" value="SPAL_0000050600.1"/>
        <property type="gene ID" value="SPAL_0000050600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000050600.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26698" checksum="FF341215ABDDD04A" modified="2015-12-09" version="1">MVKLLQYLFPIFFTVTFGFEDLKYFIRRVNGRFMCEFDPITIGIVELYYHNDKETKFIKDVKIENDGTFDFDLKVPFIPVGKYFLKIFHKCGVDYKKRIHEKIINIPISMSFSIFFGNKESLNLGQIDLKDGNIHNSNKFINNRKAISFHKYPSTDDALLNGEKDGDLDKFDFEEFFKIIKKEIKNTIRNFCKVVDNSTELSNKIRNPNEKVNLGTNLDKNNVIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B367</accession>
    <name>A0A0N5B367_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B367"/>
    <dbReference type="WBParaSite" id="SPAL_0000051900.1">
        <property type="protein sequence ID" value="SPAL_0000051900.1"/>
        <property type="gene ID" value="SPAL_0000051900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000051900.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30530" checksum="92163A8ED76341F9" modified="2015-12-09" version="1">MAFDLMRHHGVVSFVQQLCHFLTSVQTIFYINWGPTFPTIIGGILEAGYLSSIAFILVLSLNRCDLMYDFKLFPSISRKIFYSIASILCYVYYCLVMVFFLLPGNRMMFKYRHYEWSFVEDGCLTSLGFTLVKWNIYSPLIVSFILYVLTFSKIIYLRCKKQKSTYFFTEDIKLIVHIVITYVLIICMEICWNGHFFNIYKTQFGALIPQIMYILISGANTTFTLFFVRDVRNNAFGRCCSKSIVPASRIDKAQIKSTKVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B381</accession>
    <name>A0A0N5B381_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B381"/>
    <dbReference type="WBParaSite" id="SPAL_0000053200.1">
        <property type="protein sequence ID" value="SPAL_0000053200.1"/>
        <property type="gene ID" value="SPAL_0000053200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000053200.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23697" checksum="683933A45699EF8C" modified="2015-12-09" version="1">MKNFKSIKIMIYLTIILFYFLYVDGKIRCLQSYNPHSVLKAIIKECPIEGDSCVTFYTNDNPIPRHSCLSKFEFFSPQFRYIECPKEPHTARCFASSTNKSIHRIFLHRVIHLPMSDVLYRAGIDKLCCCQGYGCNNNNEKIERFLRNDHRIDEDYFEDANPSMFSYQISNAINSKSKRSTTTVSFFSIYLTITAISYILVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3G5</accession>
    <name>A0A0N5B3G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3G5"/>
    <dbReference type="STRING" id="174720.A0A0N5B3G5"/>
    <dbReference type="WBParaSite" id="SPAL_0000061600.1">
        <property type="protein sequence ID" value="SPAL_0000061600.1"/>
        <property type="gene ID" value="SPAL_0000061600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000061600.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="79489" checksum="8F2182C46D32C5D3" modified="2015-12-09" version="1">MSIGELLKMPLKEVKHGIKAKKENGQSSSSISSSILYENISDSCNNSNNKSIKNQRKNSCTPVKVNSNGKIPESHEGETLSLVDSLLGDTNDDTTSKHLNHLYDSNCKICQDKKSKEERLIREREEAVAEREAKRKRREMEIEMRIREEKMNLLKREMEEKKKMEKNLYNVTLHDGSHNIPLTIYPIKNPDLFILKDEMPRRLKNINHVRNINALKEVFEISIDSLTSRVMVCIVEADGNVGDENFLKYRKYLFKERLGIVINFEDSNLLKSFSLIPLDSFADIPDLLFDLPGYEISLFDFSTKFVGVFILEDQKLLDIFTSPPKPPILKNITKTTDAKESGDKKCCDKDSIRQDDDDGNDSKVTEKIINDDFKCHSENNDQPSSTPTCNIDKNITSSSDWMPMVSDTPKNETVSSPEPIITTHVGFKIPSLEMSEPPVPPSIELKSNSNVDVQEEEEEQPSQGGGKANKRKRSRKNRKSRNNKKRTRENSNNQSHSKFSGLSNVRRDFRSPLGPYHPRPDRRPGHNYLHDNDNVRMVEDRYNHVQSIPYNGSPLYQHQPSPSSSSLNGGVYSPRNSIPSLPRYSFSTPPSYNSRPILPLLKQEPYIKPLMEQTIVLGPQFNQPSPPNPSMYSSRIPQGISGPQSMYGNNVHGGQQQQQRPPQNNYYHHQQSSGNSKHHHYQQPYYNNFSRSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Z6</accession>
    <name>A0A0N5B5Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B5Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0000148700.1">
        <property type="protein sequence ID" value="SPAL_0000148700.1"/>
        <property type="gene ID" value="SPAL_0000148700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000148700.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13745" checksum="A37ADDBAF682A5A0" modified="2015-12-09" version="1">XYTVALALIPYDKINEGWEVILSMISSEDDNVADFFQYVYRTWVSERSIFSRSLWCHEFSSGAKTNNALEGFYSKLNRKVNKTHTNACELLANLIEIQHQSEIELSRLLSGGPLKKKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6A3</accession>
    <name>A0A0N5B6A3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transcription factor HNF-4 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6A3"/>
    <dbReference type="STRING" id="174720.A0A0N5B6A3"/>
    <dbReference type="WBParaSite" id="SPAL_0000159200.1">
        <property type="protein sequence ID" value="SPAL_0000159200.1"/>
        <property type="gene ID" value="SPAL_0000159200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="177"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000159200.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50705" checksum="26F1A2C5A97FB129" modified="2015-12-09" version="1">MTYNTDVFTVKEILKTNCIGEETQNSTIERDDIYRKIEYCKICGDLADSYHYSVSSCRGCNAFFRRAINLNMTFVCRHGGNCLINKNTRCACRSCRFDKCIEAGMDPMAVQPRKDFNRDMNKHGNENENESNMFFDNIQSKSPENDIDKKWGKETNNSINITNFTQAQMNVEDRPTSPSSTCQELSYFFDLIKKYPEDCERRRILCCDTVEEMLLPNNYLPQPCFINDIISTYKIEMSLMFEWMTNVPGFSNIPSPKDKAKLIKEFSSKFYLLNILGNTIDLGLDDKVMLVNNRYILPQICPIIDSQNMINNQLVNILYGKTCLDILVELIEPMKDMNIEIFEIIALRIIMFWNPGNIGLSKDCISYCQIYSESFIKHLDRWYELKGKDGSEISLRVAKIILLIPGIVKISHTLKGILETLGNDHLVSFGDDSLKKILTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Q9</accession>
    <name>A0A0N5B7Q9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM32A</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Q9"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Q9"/>
    <dbReference type="WBParaSite" id="SPAL_0000208300.1">
        <property type="protein sequence ID" value="SPAL_0000208300.1"/>
        <property type="gene ID" value="SPAL_0000208300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000208300.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11405" checksum="2E5BE63B4CC3FDC3" modified="2015-12-09" version="1">MKPEGVVKGTLKLKGGNLLTKKKPQTEEVKKVEKVIKKDSKIIKKTPAQIAFEKKQEQIKEKKLREKAALSYKDKVNKLNEKLENLSEFNDIPKVSWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7T6</accession>
    <name>A0A0N5B7T6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7T6"/>
    <dbReference type="WBParaSite" id="SPAL_0000211100.1">
        <property type="protein sequence ID" value="SPAL_0000211100.1"/>
        <property type="gene ID" value="SPAL_0000211100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000211100.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16108" checksum="8F7BD34AE8448D3E" modified="2015-12-09" version="1">MNTSKTGNMTYSPYEKLFLQQPHNQITRYLQSNIKYVDRNQDLHELMNVAAYIRHLDNEYSEEIKSRINEKAKIKNVVYKPGDKFMYKKNLEGKFNNLYQGPFTVLKDLDTKVTFKAKNGKILTASKAKIKRFYGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7X9</accession>
    <name>A0A0N5B7X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7X9"/>
    <dbReference type="WBParaSite" id="SPAL_0000215300.1">
        <property type="protein sequence ID" value="SPAL_0000215300.1"/>
        <property type="gene ID" value="SPAL_0000215300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000215300.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11765" checksum="7711E4E6FB379440" modified="2015-12-09" version="1">MSLNECYWIRCNRCTSGLSQTQLYLTNCGHIFCLSWLGLDTKEHMITNPICASSTHLLEMDLKLGLDKLAYFKDPEVEFKEAKKKAEKIKSFKRAAETAKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B869</accession>
    <name>A0A0N5B869_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tumor susceptibility gene 101 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B869"/>
    <dbReference type="STRING" id="174720.A0A0N5B869"/>
    <dbReference type="WBParaSite" id="SPAL_0000224200.1">
        <property type="protein sequence ID" value="SPAL_0000224200.1"/>
        <property type="gene ID" value="SPAL_0000224200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="8">
        <location>
            <begin position="299"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000224200.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41935" checksum="5E3346D5CC4B70C7" modified="2015-12-09" version="1">MSSSVRSNLTQIGSVYLERAFTDIQRALNSFVHLKDSVELFTYPSGKRKNVLTLAGTIPVVYKNNTYHIPVALYLDEKHPYQAPYCYVKPTSEMEIKESKVVDITGRIYLPYLNEWKWPSHSLVELLKVMCREFENGCPVYAKRHAPPARPSPPQVSSNLPYPVASFPIPQPSSYETTTNLPAIPQRMKQKNDSDLDGALKASLITALEEKFREKINDQVRDTYEEIIVLRNSYEKLIEGEKTLHDSLQSINNDQQKMDSFVKDCQEKISEIDNYLVNYKKTATVKPCEWIDEALLTTCPLDDQIFRSYVADCVLEDAQYYISQALKKGHITLTEYLKQIRVISQEQFIHRATLIKAREAKVSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8D4</accession>
    <name>A0A0N5B8D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8D4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8D4"/>
    <dbReference type="WBParaSite" id="SPAL_0000230700.1">
        <property type="protein sequence ID" value="SPAL_0000230700.1"/>
        <property type="gene ID" value="SPAL_0000230700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF4">
        <property type="entry name" value="PROTEIN LET-99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000230700.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="68747" checksum="1AC369471A58491C" modified="2015-12-09" version="1">MENSSVNSTGMTLFKATNLFNLIKSTFVTRMPLKKHRSYLRVYDDSFTGKEAVNFMVETLPSIISTKIVLTRSNCEQLLTFLLTKNIFYNVRNEFDTIFKDDLSIYKFYENHNEIATPVKRSYSVNESKMTLFDGRNSKYSKEKLIKSNASCKGSYSNYDFPEFATTNIKLIKFFGLNEETNIESKNSTQKDLPLQEQLLKSRNKDIPRPLSVNEVLSEGKMFSSNDKTCGIPKLIFEEISSVHITSWKFCIISFIKQHYSGKEIFKLFNIEDELVAWNCEKVGSKGIVKCFKEREEISSYLLRMMRFLARYPNDSNKMIGYDKQYCGIELDTYRNILSEISRKGVILPIPFSNALADIYSLKSTSKLKNDFSPIIKKIKESQFTKIFNRTSNKSINFGVFSRNTERSSFHNIEKRNKRIPLSNLISEKYTSDDDVENEKKSFTPILRESLPYIDKENIGFISPRKNEHQSLTSPSQKEITDSLKNELYSFILLLLPPQVRRKLHIILRFMNRISENTNIMLSQKNSNKVAVLKTMTPLLIMTKNQAHFHLQTDIIEYLMDNEADIFKIPEKLISDRNELISNCKTKTTCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA80</accession>
    <name>A0A0N5BA80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA80"/>
    <dbReference type="WBParaSite" id="SPAL_0000294900.1">
        <property type="protein sequence ID" value="SPAL_0000294900.1"/>
        <property type="gene ID" value="SPAL_0000294900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000294900.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33189" checksum="ABAFFDE654FA192F" modified="2015-12-09" version="1">MSLYIVNINFPNMKKLFYINLNILLTILISLNWFNLIQPQYTQDYEKLIYNGRRMYNQPTSTNKPLGQINVSAIFKKELGNSSKAGAYVFAVAHPSISPSKGDENILKDKSNEVPRLKAKEETNHGKKGETTQPTIEKDTSIINFALFEELFNKINSDQKLIILWIVSVISAVTLTLFFVYLILCLWNYRSRPKFDRSHVISYRRPEELDILFEERRRRNNEVARLVRETSPRMFNGQETYIPNHKDEEGKKLSRIEKEVMLLKQTSLQEADPNTRKNIRKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAM3</accession>
    <name>A0A0N5BAM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette sub-family F member 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BAM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000309000.1">
        <property type="protein sequence ID" value="SPAL_0000309000.1"/>
        <property type="gene ID" value="SPAL_0000309000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000683">
        <property type="entry name" value="Abc transporter f family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="83"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="395"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000309000.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70310" checksum="B93EC7EF42595937" modified="2015-12-09" version="1">MPSDAKKKRDAAKKAAAKAKATGKKVVEEVADDATSKTTQNGTIDINNEVDEATSLLEKVELENAAARTVAAVLTSHKHSIDTKIEQFTLTFHGKELVVDATLELNMGRRYGFIGLNGSGKSAILHAIYNRELPIPDHIDMFLVSREMPASEMSALRAVIDVDKERIMLEKLADELATDESEEAQEKLLDVYERLDEMDADMAEVKAARILHGLGFSRQMMLKKCKDFSGGWRMRISLARALYLKPSLLLLDEPTNHLDLDACVWLERELSNYKRCLLITSHSQDFMNNVCTNIIHLFQKKLIYYSGNYNTFVKTRAELLENQMKRYKWEQNQIQNMKDYVARFGHGSAKLARQAQSKEKTMAKMIAGGLTEKVVVESVKQFYFIDPGVIPPPVIMVQNVSFRYNDNSNWIYKDLDFGVDLTTRIALVGPNGAGKSTLLKLLCDDVSPTNGVIRRHSHCKLGRYHQHLHEELPLNISSLEYMGECFKDVNEVQVLRQMVGRFGLTGRDQTCPIKELSDGQKKRLAFAKLAFERPHILLLDEPTNHLDMESIDALAEAINEFEGGVILVSHDFRLVKQVTEEIWVCDKQTITKWDGDIFSYKQYLQKEIDREEKKMVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB37</accession>
    <name>A0A0N5BB37_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB37"/>
    <dbReference type="STRING" id="174720.A0A0N5BB37"/>
    <dbReference type="WBParaSite" id="SPAL_0000324900.2">
        <property type="protein sequence ID" value="SPAL_0000324900.2"/>
        <property type="gene ID" value="SPAL_0000324900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001216">
        <property type="entry name" value="Splicing factor 3A subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000324900.2"/>
        </source>
    </evidence>
    <sequence length="229" mass="26398" checksum="C89C1E6318DFEB6A" modified="2015-12-09" version="1">MDFQNRAGGKTGGGGQASYSEANVDRRERLRQLAMEMIDLSKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQQNLARRAAKDSADAQLFMQQQSNQAAKPEVRKFQKIGHPGYKITKQFDPSTGQCGFLFQIDYPDIGQGIIPRHRFMSAFEQKIEAPDKKWQYLIFAAEPYETIAFKLPSKEVDKNEDLFWYDWNEDTKQFYFQFAFKPDKGLTSSNLAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB43</accession>
    <name>A0A0N5BB43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small, acid-soluble spore protein gamma-type</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB43"/>
    <dbReference type="WBParaSite" id="SPAL_0000325384.1">
        <property type="protein sequence ID" value="SPAL_0000325384.1"/>
        <property type="gene ID" value="SPAL_0000325384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000325384.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7798" checksum="2EAA8EFFE47BAEE3" modified="2015-12-09" version="1">MPKNSNLNLINQAENATNNKMTDFEQKVAAKNSNLNLINQAENAPKKVFRKNSNQKMISNMEDGVFQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBP0</accession>
    <name>A0A0N5BBP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBP0"/>
    <dbReference type="WBParaSite" id="SPAL_0000344600.1">
        <property type="protein sequence ID" value="SPAL_0000344600.1"/>
        <property type="gene ID" value="SPAL_0000344600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000344600.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37082" checksum="5E1D054D2CFBDEAB" modified="2015-12-09" version="1">MDDNPFNKYLRLSKLKRSINQELIKKLEKETDEINGIFKCLENELNDMNLNSIHALPSSSSQYTMLSMKSTSSSVISTPEYRVETPLSRASIASSATTAALPDAVKRVQQQTIEIPMTNLTGSSITTPLSLKKNIPVMPSNEQNSSIIMLGPIPNNSEKVPIEKIINIYCHILKEPKNTDKDPKKEQKKDSIAYEGKFNKSYGASTCLVQLLHSLLKACHQKFTKPNDKIKFNVQVNSSNFLNMCDFYDKKTTPGSLTDSSVKMFESCIEYKDKLSIAFKNINESSLLQKIALYHAERYHNKTNEWNCNENMSILGNTLEEAAQVLPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCG3</accession>
    <name>A0A0N5BCG3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-antigen ligase RfaL</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCG3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCG3"/>
    <dbReference type="WBParaSite" id="SPAL_0000371200.1">
        <property type="protein sequence ID" value="SPAL_0000371200.1"/>
        <property type="gene ID" value="SPAL_0000371200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000371200.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7316" checksum="8C9E2AABC9D18976" modified="2015-12-09" version="1">MTDTDKEGETKFEDFFAHAFHRYGMFIARHPKAIIWFSIILTICTLPGFAFLKLNLDLFKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCN9</accession>
    <name>A0A0N5BCN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000378400.1">
        <property type="protein sequence ID" value="SPAL_0000378400.1"/>
        <property type="gene ID" value="SPAL_0000378400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000378400.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14319" checksum="349C5549E47BFE68" modified="2015-12-09" version="1">MEASLVVLNRDYVTAIQKITALQTSCETAVAKSKQLENDLKDYETSAATLTEHQNKKNTTLTAQVSTLENEKEALEQNTRSLEDELIEVRDKYENAQETTINLKSHSEGATNTALELQRVHQQLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD92</accession>
    <name>A0A0N5BD92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD92"/>
    <dbReference type="STRING" id="174720.A0A0N5BD92"/>
    <dbReference type="WBParaSite" id="SPAL_0000398100.1">
        <property type="protein sequence ID" value="SPAL_0000398100.1"/>
        <property type="gene ID" value="SPAL_0000398100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000398100.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37555" checksum="E2710E9C8E118B44" modified="2015-12-09" version="1">MSSTISSSEFDRQFNTKKKIEKDSFIWTIEKFSSCELKKDERMRSPLFNSKINETMKWRLDMYPKGDYNVNEDYISLWLILENIDCIELTVLCSFYVLGENGEKKYRKVMNIKRFCEINKLCVCHQFLEFDLLHNDDKKLLSNDNLILGCEIFYYCGPISTISPSTNNNTNDSMNLLLLYHQKFFHSILAEKQYELIPNIIEINGFSPDVVEEMTNYLYTGKSPNMDEIACEMLEIGEKYGLERLKLMAEESLLYNLSTENACNYLICSELYSGEILKEWCLRFIYLNAENIVNTEEWKEVVSNYPLLIAKLFNIAVNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDH6</accession>
    <name>A0A0N5BDH6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDH6"/>
    <dbReference type="STRING" id="174720.A0A0N5BDH6"/>
    <dbReference type="WBParaSite" id="SPAL_0000406200.1">
        <property type="protein sequence ID" value="SPAL_0000406200.1"/>
        <property type="gene ID" value="SPAL_0000406200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06416">
        <property type="entry name" value="GH25_Lys1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894116" evidence="3">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000406200.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24104" checksum="EDC0816F9AB1D23A" modified="2015-12-09" version="1">MKIYLLTSLLILGSLQPALAVVGLDAIQTISTSTFKCLYNEGYRFFIARVWESVGNYDYTGMQNIKNAWEGGMAHVDGYIFPCLSSGCAHAANQVEATINKLKAEGAKIGTLWLDIERLAWPSDKNYNRNFITAMVNQAQSMGVTVGIYTGYYEWEAIVGLDYSAHSNLPLWWANYNGHQDYTGFTPFGGWSKPAMHQYSGDVNGGCGVNLDQTYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDQ3</accession>
    <name>A0A0N5BDQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000413600.1">
        <property type="protein sequence ID" value="SPAL_0000413600.1"/>
        <property type="gene ID" value="SPAL_0000413600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000413600.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19243" checksum="70AFF70EBE74C124" modified="2015-12-09" version="1">MNQNNNSRQNESVINEREDEQLDQLVQAFNTLAVQNTNALQEVTKTTSMLIQAINNIQEQNKFQQQMMMSMMRQTTMLVEGIMHTRQVNEGNERIMNFQNQPVVQNPSNVQNPIGPLNFPSLRSTQESLLLSSQSNIFFESNVSRNPISAPPVPAFHSTPIVRSQGILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFF7</accession>
    <name>A0A0N5BFF7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFF7"/>
    <dbReference type="STRING" id="174720.A0A0N5BFF7"/>
    <dbReference type="WBParaSite" id="SPAL_0000472300.1">
        <property type="protein sequence ID" value="SPAL_0000472300.1"/>
        <property type="gene ID" value="SPAL_0000472300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="147"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="286"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="485"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000472300.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="76652" checksum="3BEAEF38B3D0A428" modified="2015-12-09" version="1">MSNNYIEQGDNPDLTELRKKASFNTEELSIFLAGSKSKLDKKRRIHKFVESKKELNDAKPLSFMTRSELMENEQRKKMYMMEYASEIVDISSLEDMHYYNDAVHNQDGHPFSLHGGMFIPCIEAQADDEQREIWLKKANNYEINGTYAQTEMGHGTNLRKLETTATFDEEKDEFIIHTPTITATKWWPGNLGKNANVCIVAAQTWIKGKCYGTNNFIVQLRDFETHEPLPGITVGDIGPKFGYQQNDNGFCKFDNVRIPRRNMLMKHAKVDRKGNFTKPAHDKISYSAMLYVRAVIINVLGEGLGKAATIAIRYSAIRRQGELDDPKNEVRVLEYTTQQYRLFPQIARSIAFMKLGENISKLYFNLLKDLHSGNTSYMTDLHELLCGVKAVVTHEVSLGIEQCRMSCGGHGFSQASGFPYLYGAFVCACTYEGENMVMLLQCAGGIMKSVQKVVTNKTNELSSIFKYLGEKEKKKSTISGDKVTIEEYIECLEVNARKQIFDGFKQFNECIINGMNKKKAINECAIPLIKAARRHTKLFIGKSFAESVTKLAPGSLKNVLMKILELYLSYEIMESPSGTILEGFLDDLQISIISKRIKILLSELKNDAVSIVDSYDFTDRELNSVLGRRDGHVYSNLLKWAQESELNKTNVLPSHHKYMKKLFDTRKGIYNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG18</accession>
    <name>A0A0N5BG18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG18"/>
    <dbReference type="WBParaSite" id="SPAL_0000492600.1">
        <property type="protein sequence ID" value="SPAL_0000492600.1"/>
        <property type="gene ID" value="SPAL_0000492600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000492600.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12395" checksum="9F6148B19C4C7243" modified="2015-12-09" version="1">MDLLSLPCDLKRIIFSKVDCVSLINAKLTSREFYLFIERNIRHMQKPKLYEIYVFENSDSYGNNQYHVRFGFYFFNKEKIASSIKYISMVRVFTLFKFFIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGF9</accession>
    <name>A0A0N5BGF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGF9"/>
    <dbReference type="WBParaSite" id="SPAL_0000506600.1">
        <property type="protein sequence ID" value="SPAL_0000506600.1"/>
        <property type="gene ID" value="SPAL_0000506600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894231" evidence="2">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000506600.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11486" checksum="EA4F1BCF53A9A677" modified="2015-12-09" version="1">MKDIIKMHFLKYFTILVLLVVQYSSQDDTTAYATTPECTSNCATRGSDFGTTQGPLSDSVTRKKRSFSLKTIKKTAKKLVDKAKDKAEDLVDKAKLKMKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGK8</accession>
    <name>A0A0N5BGK8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGK8"/>
    <dbReference type="WBParaSite" id="SPAL_0000511100.1">
        <property type="protein sequence ID" value="SPAL_0000511100.1"/>
        <property type="gene ID" value="SPAL_0000511100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000511100.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9235" checksum="5B076FC85D7D7C23" modified="2015-12-09" version="1">MPLEENNNNSLEGKDNYSFNEDLFVYRKKERVSGNDEDCRDNCNQSDETSGSTDVVEGDEFTDNDTTGKEYISDRKTHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGY9</accession>
    <name>A0A0N5BGY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BGY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000524000.1">
        <property type="protein sequence ID" value="SPAL_0000524000.1"/>
        <property type="gene ID" value="SPAL_0000524000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000524000.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8221" checksum="5ED0A2ACB84E45A3" modified="2015-12-09" version="1">MCSGSWPGLKWNTPSTQKVGLFKPLSFVDFAVVDSDTNAKNNLQCNWCENIMDSQALAEHMDENHLHVVEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH16</accession>
    <name>A0A0N5BH16_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH16"/>
    <dbReference type="STRING" id="174720.A0A0N5BH16"/>
    <dbReference type="WBParaSite" id="SPAL_0000526300.1">
        <property type="protein sequence ID" value="SPAL_0000526300.1"/>
        <property type="gene ID" value="SPAL_0000526300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000526300.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22446" checksum="0D05AF22192CD034" modified="2015-12-09" version="1">MCSFEVCSSLILRNKNDPFLSHLITCDEKWILYDNCKRTGQWLDKNEAPKLKLIPKNVMVTVWWSAVGAIHYKFMKLEETINSESYCQVLEEMYQKLSQKMPALTLQKLNELGYETLPYPAYSSDLASTDFHFFKHLDNFLTEKIFRNDEDIKTAFEVFIESRTPDFYANGINKLVSRWQQCVDSNGSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH83</accession>
    <name>A0A0N5BH83_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH83"/>
    <dbReference type="WBParaSite" id="SPAL_0000532800.1">
        <property type="protein sequence ID" value="SPAL_0000532800.1"/>
        <property type="gene ID" value="SPAL_0000532800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000532800.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19586" checksum="526E16080515B2D5" modified="2015-12-09" version="1">MIDIFLVIDIIQLIYKVPSMLLMMLSICTIIKEIKNKNINFNTQFYIIIVCKLTNEIVYIMTIFIFIKLPKWGFCNDFLENNDWMATIHFTLLAQETTFMFLITLLISINRYIAVKYPLSYKFYFSKSRTLLTLLSFIILSVIIGLGNILFNAKYVRVDLFDYIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHG4</accession>
    <name>A0A0N5BHG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHG4"/>
    <dbReference type="WBParaSite" id="SPAL_0000540400.1">
        <property type="protein sequence ID" value="SPAL_0000540400.1"/>
        <property type="gene ID" value="SPAL_0000540400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000540400.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13984" checksum="36C5EDD345795221" modified="2015-12-09" version="1">MTKMVAKHIASFKEDNKTQNTFLKNSVVSQESNSDIKTSIIRIENKKAVESSGGATGIIIAVVVLIVVAILAAVGFFLYKKKSKKSIMVKTAILTGTETDLTDIKIEETQQPSLSERRGAEKTAKLIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIA4</accession>
    <name>A0A0N5BIA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000568800.1">
        <property type="protein sequence ID" value="SPAL_0000568800.1"/>
        <property type="gene ID" value="SPAL_0000568800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000568800.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25378" checksum="6474D512320EBE2E" modified="2015-12-09" version="1">MKFGKKLMDMDKEELYLVYSAISKLKYPKLDIEEVQEEIIKWLLENKLSLKHIFLFYQDDDDTLKHKYLLSRNSDSPCHCCSTLPTSYKEFKNEKNEKIINCNPTRREEKKKNSIGKVDKTDVNNVSKQEREKKSDIVLSPNELIKRNENDTITRSGKTTKINPITEQPKLGEHLKNNNNKSEKKRKSNGGCCSWCRNFCTTCKAEFGKCCIDILGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIB0</accession>
    <name>A0A0N5BIB0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIB0"/>
    <dbReference type="STRING" id="174720.A0A0N5BIB0"/>
    <dbReference type="WBParaSite" id="SPAL_0000569400.1">
        <property type="protein sequence ID" value="SPAL_0000569400.1"/>
        <property type="gene ID" value="SPAL_0000569400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000569400.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13688" checksum="0CA44B060CC8147B" modified="2015-12-09" version="1">MSGRGKGGKAKSSGKSKSRSSRAGLQFPVGRLHRMLRRGNYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRINPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIPTNLMPKKGTENIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIF8</accession>
    <name>A0A0N5BIF8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIF8"/>
    <dbReference type="STRING" id="174720.A0A0N5BIF8"/>
    <dbReference type="WBParaSite" id="SPAL_0000574200.1">
        <property type="protein sequence ID" value="SPAL_0000574200.1"/>
        <property type="gene ID" value="SPAL_0000574200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010754">
        <property type="term" value="P:negative regulation of cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010446">
        <property type="term" value="P:response to alkaline pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000067">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="417"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="494"/>
            <end position="498"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
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        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>AMP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000574200.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="85731" checksum="8335A33ECA1CB6B4" modified="2015-12-09" version="1">MDLKPEDVSLYLKSNPSFLENYVCSPSITRQTFERWVHRRTTLRNRRQGSLTTSNSNLKIGAAWNPEDIGKCRNFLAENASQQINLMYELAVICAQECSSAEAVELIVHNEEDNNSYRVTKEENEIRLKRIKKIKKSYAAASYVLQVYDCNEIKETHLADIYFFGTNFNDRDVRLANIFGATFGSIFYFGKGNMKDKSKSGNESSMSTTSSQESTEIIEKNRKLTKFLLEVVKSIFQEVASMDTLIIKIMNFAQRLVDADRASLFLVDSKSKELYARIFDVGVQSEEAESLENHGQKEIRFPIGKGIAGTVAQTGKGLNIPDAYKDERFNPEVDHKTGYQTKNILCMPIFIRRMVIGVVQMVNKRTGEFTNEDAEAFETFAIYCGLALHHAKLYDKIRKEEQKYRVALEVLTYHSSCNKDEVTKVKKYQEGVDDMPPEMLNFDFNSMTLSEIEKPVFAIKMFQKLFGGRIRFDPDDLIRFTLTVRKNYRKVPYHNWQHGFTVAHSLFYLLLSTNIFKPHEALAMYIAAICHDLDHRGKNNAYMKTMSTPLAAIYSTSVMEHHHFNQTITILQQEGHNVLRYLDTEQYKEALGLIKHCILATDLALFFSNKAKLNNIIEKTTFDWKNEDCRALGQAVIMTGCDLIASAKPWQVQSETVKVIFEEFYEQGDAERMNGREPIAMMDRHKSGELPEMQVGFMRGICLPCYDLLAKIIPECKHLRENALFNTSKWEEMADEYKNKKESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIS5</accession>
    <name>A0A0N5BIS5_STREA</name>
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        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
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            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIS5"/>
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        <property type="protein sequence ID" value="SPAL_0000585500.1"/>
        <property type="gene ID" value="SPAL_0000585500"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
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    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
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    </dbReference>
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        <property type="entry name" value="zf-CCHC"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000585500.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36765" checksum="3B2B673C530F67DE" modified="2015-12-09" version="1">MDKLDQKNLGPNGTKSLTFFMDSGDRDPTALAVESFFRINLAIIKSLYPEVEEREAIREELKDHFEILLFHPIGNSLYSCFRKWRTVSPKCPFDFLLKAVETEYDIYVRNNFNLHSMKDWKQGVDEPVREYNKRYRERLAELYPDFENMPYRRANEKSERTNSLRMEVVRNYIAGLKDELIYMMSVFNSSDKCLETVMINAESYENEWIEMKERIKEEENKREYYRHLSSSVDSHKGKDKLECHNCGKYGHFKRECNERLAECKFCTKRGHLIQFCYRRRSSLIGISKSDTPRKFVALVLARNCHVIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIS9</accession>
    <name>A0A0N5BIS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein Gawky</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIS9"/>
    <dbReference type="STRING" id="174720.A0A0N5BIS9"/>
    <dbReference type="WBParaSite" id="SPAL_0000585900.1">
        <property type="protein sequence ID" value="SPAL_0000585900.1"/>
        <property type="gene ID" value="SPAL_0000585900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000585900.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="74179" checksum="3081FC7130A36CD2" modified="2015-12-09" version="1">MRNNYMYSNSDYSQNHMKNPNGQWNGPVPNVAGYMNPDFGHAMIPGPFMEAPPMMNEAYPPNSKLNQYVSGGGAWDDTNTGKVDADDVNGPSFTFNKGAANVPMHLSGTDGGFENEFKRNSGWHNKNRNVQMNIPPPTDNWNVGNSGIDHHNVQGNWPRPMNVPMGGNHMNNVPIQGGWDNMKRQQNAGNYRGNKNSYIDNNMKQNMHHGYIPRNDINFPRNNMNSGFNNTPNMLWNQNNNLNSQYINPRIPIGHHHEIPLPRQNTNQNINPPHVNVGGNQLPVQGGNRNISNQHENRNKHDSTSSMVLGNTTNHSNIQTPTENPGNVFSNAEDSYWRDPNGEMKKWQRDTGTAAWGDPEENNNSTIKRWMIPSIPDLLEGDHMISGIEKENGVKIVIARGWGDENHSGMNSPQIKSNTSVASPLYNKNENRWSPDSGKGNRLGIYGSGDGSDWEADKNAHPFSGLVKGANDMVSRDDHLQNTPPSPDLIKLALSKKYIDNSMLNRQGDPQYTKQLNLLLGYVQQASFLENQLDNFRRANENSFAANDNPEIQNEAKKNHNALIVEVARVKNEIVSLRDMLKNRLSGMPSPSNCELPPGSLLHSIKSDYNFTTTNDDFLHDTLTTTNAGYGMDSASAAVNRALANLDISGSDNQSGNILASTVWNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIY9</accession>
    <name>A0A0N5BIY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polo kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIY9"/>
    <dbReference type="STRING" id="174720.A0A0N5BIY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000591800.1">
        <property type="protein sequence ID" value="SPAL_0000591800.1"/>
        <property type="gene ID" value="SPAL_0000591800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLO box" evidence="7">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000591800.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="29175" checksum="62A8B58E71C3DC85" modified="2015-12-09" version="1">MECIIGFFSLGRPKHFVSRWIIFDEECSLGYELTDSSVGVIFKDNSRLIADDTMENFQYIDESNMREYFEYDKFPTKLKEKSNLLDYYKDYMETEYDKFPTKLKEKSNLLDYYKDYMETYLVADQPLDERERTKVIDKGIPILLKWKRNDKCICFLLLNGVLQVNFHEDHTKLIISAPTKSISIIDKDNKLETHWYKGVHLFGWNAFKEKKLSYVMEVVEEWISLEKKHEDDDSAVQAKTINNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ40</accession>
    <name>A0A0N5BJ40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PAP2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ40"/>
    <dbReference type="STRING" id="174720.A0A0N5BJ40"/>
    <dbReference type="WBParaSite" id="SPAL_0000596500.1">
        <property type="protein sequence ID" value="SPAL_0000596500.1"/>
        <property type="gene ID" value="SPAL_0000596500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF4">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="163"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000596500.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34142" checksum="E4ED0839C9A136E6" modified="2015-12-09" version="1">MVEQTSKNISSISQKDSLDLKKVFLAFFILIFGWVLNNVVLAYVHDRVPLDQPPLPDIFFELFPEIPGAIEITEIIMLFIVISAIIVMVFHKYRWVVLRRVFCCAGISYIFRAICIFMLQVPVPSKNTYCAPQMESSLSNIINRVISTFWSAGIEALRPRVLCGDLIVSGHTICLITGLQALKLYSPKKLLFLLSFYKIATLIAILAILIARKHYTIDVFLGYVVATNVFRTYHSLAYSYHRNELYENLHSESIIKPLVIYFEKDTYSYFFDNYLDISSYIKKIPICNFEKKNMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ49</accession>
    <name>A0A0N5BJ49_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Laminin subunit beta-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BJ49"/>
    <dbReference type="WBParaSite" id="SPAL_0000597400.1">
        <property type="protein sequence ID" value="SPAL_0000597400.1"/>
        <property type="gene ID" value="SPAL_0000597400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005608">
        <property type="term" value="C:laminin-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070831">
        <property type="term" value="P:basement membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000084">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000065">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000138">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000004">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000010">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000135">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000280">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000001">
        <property type="entry name" value="Laminin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000333">
        <property type="entry name" value="netrin-4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000224">
        <property type="entry name" value="Usherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF375">
        <property type="entry name" value="LAMININ SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21199">
        <property type="entry name" value="LAMININ_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894333" evidence="15">
        <location>
            <begin position="28"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="18">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="344"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="407"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="467"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type B" evidence="17">
        <location>
            <begin position="557"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="779"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="827"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="874"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="987"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1146"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1300"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1459"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1622"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1762"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1148"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000597400.1"/>
        </source>
    </evidence>
    <sequence length="1795" mass="199657" checksum="08F21C669E198F02" modified="2015-12-09" version="1">MARNIILKLWCITALLSIYYNINYGEAMLEEDMCNEHSCYPATGNLLIGRKHQLSATSTCGLKKRERFCIVSNLDGNTSCYYCDSRKEWKPYPDSSRLSHRIENIVTENGLERTRNWWQSENGVQNVSIRLDLEAEFHFTHLIMTFKTFRPAAMFIERSADFGRTWSIYRYFAYDCASSFPGVKEERPKNHGDVICTSAYSAVSPSSGGELVYKVISPQIRTGNPYADEVANLLKITNLRINFTKLHTLGDDLLDYRPEIHEKYYYALYELVVRGSCSCYGHAQRCIPIDGGDQIGYDNPDMVHGRCECTHNTKGLNCEKCEDFYNDLPWRPAIGNQSNECKRCECNSHANSCHFDRAVYQESGFVSGGVCDNCQHNTQGKNCEQCKPFFYRDPNLPIYDPYVCRPCNCNKAGSLNNGICESEQDEERKLVAGKCYCKENVDGPSCDRCKNGFWKLNGDDPLGCRACTCNTLGTINNEGCDKVTGECTCKRLVTGENCDQCLPEHYGLSDNPEGCSPCDCDIGGSHDNQCDILTGQCKCRPHFTGRRCNITESSFFCASIDHYTYEAEDAQSIGVLSENEPRLPSKHETHQEWTGTGYTRIREGTTLDFTIDGIQKSMDYNVVIRYESEHDNIGWENVQVFINRPSKPDPYSPCANSNVENDMLLARLHPNGRYVELRPSVCLDANVVYDVKVVFGEKRTNHPNRGASLLVDSILFVPPTEELDIFKGEGTNAYHREEYNRYQCRNYALSLYPANRIGEVCQRYICPVAATFIGQGLQCDCDPTGSVSGICKSQGGQCECKPNVIGRRCDKCAEGTYGFGPSGCKPCDCDNTGALHNFCDKETGQCLCTAKGITGRQCNQCYPGFWKFPDCLTCECNEHASVCDQKTGACIECRELTDGHQCERCLPGYFGDPRLSVNIPCKPCRCPGGPGSGSQHADSCYVRSSLDYATQDIVCNCKHGYTGKHCDECDVNYWGNPRELGGSCEKCDCNGNIDPSVPGNCDSLTGECLKCLYNTEGSQCELCKDGFYGDAKIRNCQHCVCNKFGTNSTAGECDRVSGQCPCLPNVIGKTCDQCEVNHYNLQSGEGCSSCDCDPSGVVMGHDGKPHLECNPINGQCSCKQGRGGRTCSECEDYYWGDPVNGECVRCECNPYGSASMQCNRDDGTCICKTGSGGPQCNECARGYTGVWPNCKTCGECFQNWDNILQKLAMDMEELTTKANNIEDTGIASVYDTEFNEMDEKLGEIKKQLAASNMSALDIAVLDDKIVLLRENILKAQSRHNFGSDLVSQTANKVSMAKSQMKILKDDVNQLTIDAQELSDKATQLRETDIFGAYNVTRESAEKSQKAIKNVEDAISKFTEAESKSHEAQTLLDKHKDDFEKQFEENTVALEKIEQEYHSLISVAPKINQQVCGKETAPCDALCGGPISLCGSCGGKSCPEGAVSLALQAQEFSDDAFKTLTLKQNDAESMLAEIRKLKQEFSSPLSDADSALSIANHSAQEVNKTVSDINKLLNEIKEFNTNVNRTKPEQVEEIIKNIDEMEISQTPEEIEGLANQIREQLSKINNIDEILAETRGNKSTAVDLKKKADTASKAAEEAKAITETIKKTVDATNEVQKIAKKIVEDATGKLNDAKTNYDTASKEAEEINVLLEKITKEYDELSKQWTDIQVQYLRSADLRKVANEKESNANDIIQWSAIAGEILKDNISAAKERLKERKSGSEVPQQRAEELRKRATDLLTKRLSQNNEIENLLKDIAVADVSLDDINNSIDLETVRIEEATNKIKNLEDYYATCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJP6</accession>
    <name>A0A0N5BJP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EB1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000616850.1">
        <property type="protein sequence ID" value="SPAL_0000616850.1"/>
        <property type="gene ID" value="SPAL_0000616850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000616850.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11808" checksum="C0DA9BF5F856CD0F" modified="2015-12-09" version="1">MTYVLCSLVEVETKVRVNENHLHNGFLKPSIAEQEVKRQVEIKKVKRQYALLILQERDMYLQNNRLSEEALKEIADDIDLDVNFCKDMVLQQKIEGWEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJP8</accession>
    <name>A0A0N5BJP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telo_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJP8"/>
    <dbReference type="WBParaSite" id="SPAL_0000617000.1">
        <property type="protein sequence ID" value="SPAL_0000617000.1"/>
        <property type="gene ID" value="SPAL_0000617000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000617000.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65694" checksum="03B7C2660A121A74" modified="2015-12-09" version="1">MSNNDSEFVDFLQNAIEKSDQTVNNNLLLIEIGKNTNNGFEATDGYSKLLRTKFKRISVTFLEEVQKYKRVYIRVKEIKIHTRYDFSLNEFHKDLEVIDYDVVKDKTFSLINKELKVVNTKIDIGPINEPYRPEAGEKKLEDVYNMGENVSCWVNVLVVLKISPDDNIQDNSENHSLNILVADYRNCTMNCAAFKINSNNNFCKDIEVGKFYKMKLSNAKLLNSTKSCTRHFVTIKKGIHLTQTTVSFEPSTNKFNYQAPYSFLEYMNVIPKLSNNNPINVVGIVARIDEITTVSSDSMKTPTSRRIIYLTDGEIIIPIYVYGELAHFNFETKQLIGVRYGNVKKHVVCGNVIICNRLSRMDNVDTCDYMDIFSKISTINFEELKYPDLTTLPTVGEVVHNKGKFLLHIRDTQKRKVQPYKFYTIGKITSFTNFVKPDKKKKNQQENQEKDTTDEPYTRININDSIVSIPDVTVFVNKMSNIAPGLAEDIEKLIANNINMNEYLEKLKNIPMVFKIRLDNHKYLANNGQILYLPNKLCEFVDFCPSEEYSDWIERIRKDIKDLVNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJQ3</accession>
    <name>A0A0N5BJQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000617500.1">
        <property type="protein sequence ID" value="SPAL_0000617500.1"/>
        <property type="gene ID" value="SPAL_0000617500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000617500.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18295" checksum="F7379F677DA06973" modified="2015-12-09" version="1">MVEHEDLNKKTIEFSDASNGYILIAGYDEFKFNDIYDYPPNDDYDRIYFLKVYDGEHVCYSKNFRSARITSVAVNKYCKDGIEFCVGLENGNIHSTEFSLANGDRETPHENILFNEDKKINSICYLGQNDIVYSVGNCGIYNIHINRMDLKKKLVEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK58</accession>
    <name>A0A0N5BK58_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK58"/>
    <dbReference type="STRING" id="174720.A0A0N5BK58"/>
    <dbReference type="WBParaSite" id="SPAL_0000632300.1">
        <property type="protein sequence ID" value="SPAL_0000632300.1"/>
        <property type="gene ID" value="SPAL_0000632300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="70"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000632300.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39645" checksum="F1B7F0317AA2AB03" modified="2015-12-09" version="1">MLDILLWIIVLIIILGGISLAILSFITPYPKRSRKDFMEKIYSYKKGGEFDNLLSENGSRIFTDPKCYLSIIIPAMNEQERIGTMLQECTEYLTARSKKEKDFTYEIIVVDDGSRDDTSEVAYTYAMNNLRVLKLAKNKGKGGAIRDGVLHCGGKMILFADADGATKFGGAIRDGVLHCGGKMILFADADGATKFSDIEKLENKFKEMVNDENEIDYTFPGIVVGSRCHLEEESIAERSLFRTILMKGFHIIVYLLTVKTVHDTQCGFKLFSRAAAARLFPLLHIERWAFDVELLYLAEKLHYPISEVAVEWKEVDGSKIVPIWSWLQMGRDILLIWIHYLTGKWSVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKE5</accession>
    <name>A0A0N5BKE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKE5"/>
    <dbReference type="WBParaSite" id="SPAL_0000640300.1">
        <property type="protein sequence ID" value="SPAL_0000640300.1"/>
        <property type="gene ID" value="SPAL_0000640300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000640300.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16797" checksum="697B4FF170728314" modified="2015-12-09" version="1">MTSTYQVSGGEAISSDTDVTQHGTIGKYVYAVDDGPNSDFIKCVFQEKYDTNKTVPLLCQKPLGCCIEGCCPKDTLWMPALFVLLAFVILIFLVGCCTWIFSYQRSKNKQRKEEKEFYEMEKNYADNMSQMGGYGQQHPAYGNYGGVMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKH9</accession>
    <name>A0A0N5BKH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKH9"/>
    <dbReference type="STRING" id="174720.A0A0N5BKH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000643600.1">
        <property type="protein sequence ID" value="SPAL_0000643600.1"/>
        <property type="gene ID" value="SPAL_0000643600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894417" evidence="5">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000643600.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17261" checksum="59621A8CDDE74093" modified="2015-12-09" version="1">MISKAILILFFLLYLIVDVIARCKYYQSVAVWGRVLCDGRPQNNVKVKLYEDDKWLDDLLNTTETNCNGVFKIRGSHYEKGPMDIHVNLYHYCTNGHRVCPRKYKIHVPYRFVFRGPRPRRPYKLGTIRMRSWEKKWGKRDCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKJ2</accession>
    <name>A0A0N5BKJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000644800.1">
        <property type="protein sequence ID" value="SPAL_0000644800.1"/>
        <property type="gene ID" value="SPAL_0000644800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000644800.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36902" checksum="185B8948F24706EC" modified="2015-12-09" version="1">MDLNILSLPPEILAKIFSNIPWNKLINVKLAARDFNYVTEKYHKHMQKPKLYEIFFEDDRTGDDGIDRIKIIYSIYIAGGNGDNTDEKEFIFPSSELYQLHRFLQKVDLTSLNNVDNDFCNNTEVIRIFSGYFHNTNRIETMCVAAGGSVKDLGNTLPLLEKIQKVRDLKLFFYFSHKSVPGDFIIPVRDSLEILEIIESKDTNIINPRMIKFIVENNPNLSKYLLKFDDFQTYKMVIGTIVKEELARRNNGCSHKSIVFYLDISNFEGISELLSYFNSEELPYNDADTIPDDYFLYLNELECPVCGEFDKILIVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL36</accession>
    <name>A0A0N5BL36_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL36"/>
    <dbReference type="WBParaSite" id="SPAL_0000663700.1">
        <property type="protein sequence ID" value="SPAL_0000663700.1"/>
        <property type="gene ID" value="SPAL_0000663700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000663700.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29279" checksum="DB891B5F480D7ABE" modified="2015-12-09" version="1">MSVDKTIVELTRTLEQLGTLVEHINGQISGITGRINGTLNELDNAITGITTEAKTLTGQLGDAVSQVPKSWVFYLLFITLIVVFILLSILIFMNLLTKSYYIYKIIKGSDTIDEESKRKYRDDIYSGQTTPLSEDKASGHISLPINMEDGFNRSIHNRKYNTNISQRQIPINPGISYDGIGKPTNQQIYNINHESGIIKNNLQDNNLSRRTYLRKGEEINSNIGVGARYNVSTGTTVPYYNNNTNLSNLNTSPVITSRAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL74</accession>
    <name>A0A0N5BL74_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL74"/>
    <dbReference type="STRING" id="174720.A0A0N5BL74"/>
    <dbReference type="WBParaSite" id="SPAL_0000667500.1">
        <property type="protein sequence ID" value="SPAL_0000667500.1"/>
        <property type="gene ID" value="SPAL_0000667500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000667500.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33113" checksum="1419D735E07F28BF" modified="2015-12-09" version="1">MVSYSWVTLATNDDYAIGALVLGESLKKVQTKYNLHIMVTSQVSPAIKERLSTVYNNVSHVDVLDSNDKTNLRLIGRPDLGITFTKLNCWRLTQYEKAVFLDADTLVLQNADELFEREELSAAADIGWPDCFNSGVFVYKPSNETYERLLDFALSFGSFDGGDQGLLNDFFSSWSTGPSDRRLPFTYNMTAGAIYSYAAAYKRFGKNIKIVHFIGANKPWNTIDSPHKQEHFDQWRSIYNKSVLSTIPEQYQPSVLGGEDQRSKWEKGQPEYWGCDAYENIQKAIDRSMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNG1</accession>
    <name>A0A0N5BNG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNG1"/>
    <dbReference type="STRING" id="174720.A0A0N5BNG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000744000.1">
        <property type="protein sequence ID" value="SPAL_0000744000.1"/>
        <property type="gene ID" value="SPAL_0000744000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000169">
        <property type="entry name" value="DNA-binding protein SATB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16534">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CMP" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="197"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="428"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000744000.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57339" checksum="38B88E8153C082A1" modified="2015-12-09" version="1">MTMFPVRVVIESVKSENCITCTTSGSPLVDTYAVISTNTPLSQLTDSILSALGYTNLINSSRGLVQISNWKPLTFESICDNPEEKIGDLIKDFANNVTLKIITKRTSVDLDVESCIKDVKQKILKYSLDKQPQILNSISNYQIKEVISQICSGSDPTLLTKEQMENLTEWADGLQNVCPVEEERKSNESPFRFHHLHEIPKLERWFKFDPNPSKHKLNTYLTELNNSQYRQRGHKITQSQLSNWFTTKRATQRTKQSAEVNLQNFFQGFHALAGLTNIGINDFKGEANTSNPFSSLLSDNDRIDGGSDSPTPEDDVSEHSASNTGITEIDQAKTESTSPDITLDISSSFNTSSPKQRPSPGFHSLLNLQASGASLNNLNPGIKGELLTALQMAATVSNVNNNHTTTNNNSNSQNTTARSRLMFDPLSELPVLEKWFEENPHPGWLQIERYTDYLNNAPYRANYPPVSTHNVKIWFKNRRAKCKRMQTNDTNNSHSTPNILSENNITSILYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNM2</accession>
    <name>A0A0N5BNM2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine 5'-monophosphoramidase HINT3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNM2"/>
    <dbReference type="STRING" id="174720.A0A0N5BNM2"/>
    <dbReference type="WBParaSite" id="SPAL_0000750000.1">
        <property type="protein sequence ID" value="SPAL_0000750000.1"/>
        <property type="gene ID" value="SPAL_0000750000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="7">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750000.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20433" checksum="76C577487CC4ED1F" modified="2015-12-09" version="1">MDSVKGCIFCELLQTKKEVILKENDDLAIIKDIKPHAKHHYLVLSKKHIGKIGDVRASDIDFIKQMESIGREFLRIALKSKGEADIVEDMLRIGFHQWPLLTVKHLHMHILYPISSMNIATKHVIYKPGRFFKPVTEVLVEMQEELLKSDNTSPAAKEMKAQHKASVNPAELAEAITGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNR5</accession>
    <name>A0A0N5BNR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3301 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNR5"/>
    <dbReference type="WBParaSite" id="SPAL_0000754200.1">
        <property type="protein sequence ID" value="SPAL_0000754200.1"/>
        <property type="gene ID" value="SPAL_0000754200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000754200.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15583" checksum="AC5966B760BE7AEE" modified="2015-12-09" version="1">MQIIELYFQCFTLTSFLFAIIILFLFSISKYLKRLESYDRKCIQAIHQSLEATADQQRLSEVGNDDISVEVTRCLNTTKASTMGLYDYNMSNEILFSEQTQYFDISCCNQESLPCHRHGTLPVQKCVTNDFDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPE0</accession>
    <name>A0A0N5BPE0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPE0"/>
    <dbReference type="STRING" id="174720.A0A0N5BPE0"/>
    <dbReference type="WBParaSite" id="SPAL_0000776600.1">
        <property type="protein sequence ID" value="SPAL_0000776600.1"/>
        <property type="gene ID" value="SPAL_0000776600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000776600.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36881" checksum="C1F8E60F8AD47E6E" modified="2015-12-09" version="1">MEKEDSGNIVLNDKIGHYFGDLNMTNLTDQQFLDEWGRILINPEQPMKRRFMALMQLRSAPCNRSANWIVRAFLDDSALLKHELAFCLGQMRAKVAIPALFDILNKKDEDPMVRHEAAEALGAMGDPSVIEELTPFLEDPIREVRETVELAIERLKFFENKPDGFIDGNDKFYNTVDPAPPMDSNNVAELEKILMDPNEKLFKRYRALFALRNLSTDESIMAISRALECEGALLKHEIAYVLGQIQSPLAVEELIKKLKDVEELPMVRHEAAEALGSIGTKKCEEILTEHIKDDERVVRESVEVAMSIVDYNQSGEPVFEFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPP2</accession>
    <name>A0A0N5BPP2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPP2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000786700.1">
        <property type="protein sequence ID" value="SPAL_0000786700.1"/>
        <property type="gene ID" value="SPAL_0000786700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000559">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="368"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="655"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="875"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000786700.1"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142552" checksum="7C5F1DF70C4AAA70" modified="2015-12-09" version="1">MIVFINKKVTTTQSRPSGMALLKRFETQSARVKGISFHATRPWILAALHSGVIQLWDYRMCTMVDKFEEHDGPVRGIDFHDQQPIFVSGGDDYKIKVWNYKQRKCLFTLLGHLDYIRTTFFHKNYPWIISASDDQTIRIWNWQSRNSIAILTGHNHYVMCAQFHPTEDIVASASLDQTIRIWDISGLKKKNAPPGMGGSMPSRVGSGAGPLSAAQGDLFGQPDILVKHVLEGHDRGVNWVSFHQTLPLLVSGADDKQVKLWRYNDVRAWEVDSCRGHYNNISSVVFHPKAELILSNSEDKSIRVWDMQKKTCLHTFRHDNDRFWILANHPSLNIFAAGHDNGLIVFKIERERPPYCMNGNIMYYVRERQLRRLDLSTKDDIQLATLRHIRNSPPHYSMHFNPAENAFIVVTRPHNLEGSTYDLYKLSKNAGENGVAEEPTPQRSIGIGAVWIARNRIASLEKNGTVTIKDLQLKEVRKIEHNLFIEDIFYAGTGLLLLKTVEGLQMYDIQQKRVVASIKANKVKYVIWSSNMEYAALISKHTLTLMNRKMEVLYTIQETVRVKSGAWDTNGIFIYTTTNHIKYALTANEHGIIRTLDTPLYIVSVENNVLYCLNREAEPIIVNYDPSEFRFKLALIERRYDEVMRQVKCQGLIGQSIIAYLQKKGYPEVALHFVKDVKTRFGLALECGNIQCALECAKQIDEHSVWEALGEIAMMQGNHQIVEMCYQKTKNFDKLSFLYLITGNLAKLNKMMKIAEIRKDLNGLFQTAVVLGDSETQIRVLKNVNQYSLAFLAAHTYGDEEAIEELTEILDSHEIPLPTVNESATPLKPPLPIRPMTENWPLLVAYKSAFDTIAAQVQNESKPNGKGVTATMKIETTDAFAADEDDAVGDAWGTGDDYLVDEDGNLEIDEGDLVVGDDGEGGWDVDEDLEIPVEAEVTKDGEEEGQFYTVPSRGQPPSHYWPSNSRLVADHVASGSFESATRLLTDQLGIVRFGQFKDTFLSIFASSKTVYCGAGLSTPNFSFPLRNWQNAAYKNSLPATGYKIKTLARRLQEGYHLTTSGKFNDAIDKFRQILLSIPLLVVDSEQEANEATQLLDICREYLVGLLMEAARKELPKATSEDHIRNCELAVYFTHCQLQPVHQILTLRAAVNLCFKLKEMKTCASLCRRLLDLGPKAEVAAQIRKILSVAEKDCVDANKLNYDEYNPFVICSRTYVPLYRGKPQITCPFCKSSYAEEFEGEICDVCEVAEIGKGASGLRILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ76</accession>
    <name>A0A0N5BQ76_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ76"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ76"/>
    <dbReference type="WBParaSite" id="SPAL_0000804400.1">
        <property type="protein sequence ID" value="SPAL_0000804400.1"/>
        <property type="gene ID" value="SPAL_0000804400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="475"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000804400.1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="130762" checksum="8CBF7447A3418B82" modified="2015-12-09" version="1">MLFFSNEITVDESIGDGRKTILSFLGNLSSTKFLPPTLRSHIVNTTKKSLQDNCQRYHNECLWYDEAQPTATVHCIHINKITEYYANIGDPGRMAYDDNADILPKLKKSQLIDLLQTSGKLKRLVCRTTFDGNDFNIFRLKNALVFSDLKSHVKEAEKTPILLSWLSESVVNTLRQAFGTKLATTDMEMVVTFLEQQYAVREIASLHGQVTAQMQEFKNTFGELNPHVMVHLLLNMYAEPLLTEAKKIAENLMTAEPKEEEKVQKIREMELNDNNINIDDFLSSELNKIRLCTIPIHCDTCSDNVLMKLDTGSDVTCINLSTYANLKSPKLLPTNFSASSCTGSSVRVHGYFVAEVAFQKNVKVYVADIQRNLLGGVTVWRYILKLVTDREKELVKLKQKEVFEFQQVEDLTLRQLIIDSFPDLVSTKLNPDGIKHFELDVKLKKNAHPIFVPPRIVPLPYQDKVKKTLSEWEEEGIIKKIDYSPKWGSPLLIVPKDDSIRLCCDFSGSVNKMVKIDKFNIPDTSQLLQDLATAKYYSHLDLRSAFLQMKVTPKLSKLLILTTMDANYEFLRVPFGYVNSPMQLQRALQFVVSSIPNVKVYADDLLVYAETRQQLQEYTLAVCKRLNEFNFRLNMDKSKIGVTEVNYLGWHISKGKRQPAMERVKDLQNLRSPENLNELRQFTGLVSHYSIAIPELHKYRSTLDALTRKNAQFHWTQNIERCFRHIIQLIMYHTLLHIYNPKYKLGLSTDASEHSMGGCLQQINPVTRQRETIAHFAKTLTPTQQRYSMTEKEGLACLTGCKKFRYYLFGKPFVGEVDHKALLFIFNHSREISKTTSARLQRWAYELTQYQFELMYCNTKGFAHADTLSRLIQRTKAEYDNDEELVIAKTLTNFSKEQIAEETVNDPLFKEALVSIQQNFKSLSISKELQWFRRNRKHLTILDNELILYKKRVMLPRRLQEKFLEVIHHGHPSFNSMYNQAKNEVYFPAMQFELRRLYDKCDFCQQARKKARRVYGTWNASKARQYIHGDIVYLSDSNNSKYLLLVDAFSAFPFMYKLRDISSESVKKAIHQFELDFGKPDTYIFNQGTQFQGLHDINNKILVPENSQHANGVCERQVQRLKKCLLRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQT2</accession>
    <name>A0A0N5BQT2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQT2"/>
    <dbReference type="WBParaSite" id="SPAL_0000824400.1">
        <property type="protein sequence ID" value="SPAL_0000824400.1"/>
        <property type="gene ID" value="SPAL_0000824400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894795" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000824400.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22552" checksum="42D65297305C8700" modified="2015-12-09" version="1">MGLILLLIYFKLFIILSESVPYKMRNIYNIEVEGEVYTYNGLRNGDLGIYIMVMKPGKSFNNTALFLKDEIYAKLNQGIYCKINWRINKYEKNIAKEICYTEDDTHFISKECVKESSEACALKNVDILIIAPKDFQFKEVFDTFNITFTINDIILQKKYNIVKKNKYFIITSNGPERDYQFFKDIAKNGDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR34</accession>
    <name>A0A0N5BR34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coil containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR34"/>
    <dbReference type="WBParaSite" id="SPAL_0000833800.1">
        <property type="protein sequence ID" value="SPAL_0000833800.1"/>
        <property type="gene ID" value="SPAL_0000833800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000833800.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8067" checksum="5CA2FCEF396BB264" modified="2015-12-09" version="1">MMSPKQEAIISKLEQRRAELINQIKKKIFLKLKDNHRTGVVEVSHESSRYRILRDNFLRATTNLDRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSA6</accession>
    <name>A0A0N5BSA6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSA6"/>
    <dbReference type="STRING" id="174720.A0A0N5BSA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000875000.1">
        <property type="protein sequence ID" value="SPAL_0000875000.1"/>
        <property type="gene ID" value="SPAL_0000875000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894895" evidence="1">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000875000.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15273" checksum="AF6B64D6F1BEB5F1" modified="2015-12-09" version="1">MKWLTLFFALLSVTYGTIVFKQVPISSGSSCGSSCGGGCGAAPPPQMPSCGRKKREVGEAPVEVTHENVICTDDHLKKVISENLSDDVKQSINDIRLGLMRNETDSKFAVICGQQTFSFKSRSNKLCVVGNAKVTCHIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSF0</accession>
    <name>A0A0N5BSF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPX2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000879300.2">
        <property type="protein sequence ID" value="SPAL_0000879300.2"/>
        <property type="gene ID" value="SPAL_0000879300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000879300.2"/>
        </source>
    </evidence>
    <sequence length="461" mass="51696" checksum="C06EA510095B9CBF" modified="2015-12-09" version="1">MSGGDMYDRISLMSIDFSKAVRIPECIDDSTWLSLDTESLVDTLDLNLQNDKYRKQQDPIYNNPSKPFTIGLFLGAFNRFSDYFFEKLLFSSSDKKRKQLLSKFEINNQSLSNDEVKFRLADVDSKANVQSYTAVKSPMKPSNTFLNTTNRIQPTIVEKGRSREKESKLPQCTSIRTRSVSRNALNRFAIKQPPLVHETVEKTPQKTPSPKMSFFSKLTSYKSSSNNNSSSKSKNAPKKYSDVDKAKIDEINIVAKKQEMALMEELCKARERIAIAQNNDFSRPTSSASNANNNTNFHNKSMEYINTIDREQNNNLDDCMLSERNYTPCGRSRIPLKTGIPVSSKLSIVKTPFRAFSSFRSRESSTTPLSSRDNSFTGINCNTPTHGKTTNREYGGKGDHPLYRSSCSSSTSSSLTKASSGSPMSQSGYALSSGVNTSSLLSKNAPKQQLSVDDRWIDECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSW5</accession>
    <name>A0A0N5BSW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(I) chain-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSW5"/>
    <dbReference type="STRING" id="174720.A0A0N5BSW5"/>
    <dbReference type="WBParaSite" id="SPAL_0000895600.1">
        <property type="protein sequence ID" value="SPAL_0000895600.1"/>
        <property type="gene ID" value="SPAL_0000895600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000895600.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="29677" checksum="15093597D7396A61" modified="2015-12-09" version="1">MSKKLGKIFSGMFNNGSPSGSRGYSSKDIDALTAGGAGMQGPMGGGFQGNTQGGMQGPMGGGFQGNMPGGMQGPMSGGMPGNMPGGMQGPMGGGFQGNMPSGMQGPMSNGMPGNMPGGMQGPMSNGMPGNMPGGMQGPMSNGMPGNMPGGMQGPMSNGMPGHMPGGMQGPMSNGMPGNMPGGMQGPMGGGMTSGMDPNQFSMPGLPGGMSGGMSGRMDSNQFSMPGQPGGMSGGMSGGMDSNQFSMPGLPGGMSGGMSGGMNSNQFSMPGQQGGMGGGMSGGIGPSQYCMSGQSGGMNGSNYMFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT20</accession>
    <name>A0A0N5BT20_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BT20"/>
    <dbReference type="WBParaSite" id="SPAL_0000901400.1">
        <property type="protein sequence ID" value="SPAL_0000901400.1"/>
        <property type="gene ID" value="SPAL_0000901400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="638"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="1167"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000901400.1"/>
        </source>
    </evidence>
    <sequence length="1442" mass="166562" checksum="BAB3C97CA7B7DEC6" modified="2015-12-09" version="1">MNSKKMETLAKTHNLPMGIKYLASFMKTAEGNPTVGLFDEFVRWNEAAIKNTFPTTEERILMNEEIKRMFQDLLSKPMDNVFHIAYVTAMERYSQGSYKGVLDFARMTALQSIRNVANRAAIKAVRQGFNETVEQYSKRFRAALDNHWPGLTTKYTDIENEDPLNPFSEGDIFIRQELYAYYTQGLRENIAMRLTTIPARKQCLRAVIDQALQAEGFVNIRRPAEHRNPRVPVVAVTASKPEGQRKGFFQKKKPPMACFNCDKPGHWANECGAKPAQCHICGRSKHLAKHXVQKDDVLTKEIETVALKAQMDRTDNEMKEALKNRYAVLWINDMISPENDGSSVSLMNNKLWKELGEPTLTNTYISLENTHETIELKGTYKESIQVKDIVVNENLYISEELIYPIILGRTFLSQFGRYCHDYKNNRIILGKHTFIALFHNEGDPVFLRNQQALLIQPGRNHLFPVYGKESPCDGLVKMKLNKKANLPIGLLSHKGVGRLRNGKTVFAVTNLTPNPVKIPKDTPVCVAVKIQPDEIIKAEDEYISEEANWEAELPEPRRSKPLSNQELLKLVNGPQDVKDLIIKWKEVFYEYEHDPGRYNGHIEHRIRLVDGAKPVRTRLRKYRPKEEEAMIRILNDLEKNKQITKSRSAWAFPVIMVPKKDGTMRKVVDYRGLNVLMEPETSVLPLIEDVLEKVAGCAYYTTIDLASGFFQIPLDKASRALTAFITPKGLYEYTVAPMGLTSSPTAFQRVMEETFGGLRGNVLVYLDDIIVYSNDLNEHKKLIEDVFRRLQKAGLKAKLAKSVFMNEEVKFLGFVVNKEGIAVDEDKVKAIKTMRIPWDRKSLRGLLGATGYLRRFVHNYAKKAEPLTRLLSEKVEFQWGKEQDDAFELLKKELTNAPIMKKPDMNKKFVIHTDASEYAIGAVLLQEDENNQLRVVSYASRTLRDIEKRWQITEKEALAVVFAVRKFHYYIWGKTTDIYTDQRAVVAIQRAKENQTKLRRYQLALMSYSLNIYYKEGKANVLADLLSRNTTLALRIKNESADILSTIIKFRNPCQMDKWTMNNRERTQLFQELKSKVEQVRNLAIVETSRGKRVFVPEAFREQLIKDWHEHPMLGGHFGKERTTKSLQQYFWWPELQKGINFNCEMCNKTKFQPGTTYPGWQGKWSPPEKPFRNINMDLRGPLPETDRYHNYLMVLQDDLSKYVLTIPLRKATGEEIVEKLVTQVFPIFGVPEVIRCDNAQYFNSNLIQLAMEEWQVKIRFSTPYNHTSNGEVERFNRVINETIACYGASRNWDVVLPLVAGAYNNQDHSTTKTAPVKIIFNKYHSFPENSFHLPHYLDFIEHRQEYDEILGRVRKLIMSKSKTINKDHGFKIGDQVYKKLLDRVGNTRKLETRYKGPYKLIHIDEETGNCQLQSISRYGRANEKKLVMAHIKQLKLDKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUG4</accession>
    <name>A0A0N5BUG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rad51 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUG4"/>
    <dbReference type="STRING" id="174720.A0A0N5BUG4"/>
    <dbReference type="WBParaSite" id="SPAL_0000948266.1">
        <property type="protein sequence ID" value="SPAL_0000948266.1"/>
        <property type="gene ID" value="SPAL_0000948266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000948266.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9237" checksum="CB0BA8A9E146DC59" modified="2015-12-09" version="1">MDLEIVLDNISIARAFSTYHQKDILVEAVVLMAAYRHSFIIADSFQECGKFADRQAYRARYLRHLLKLVDEFGVVVVMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVP7</accession>
    <name>A0A0N5BVP7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVP7"/>
    <dbReference type="STRING" id="174720.A0A0N5BVP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000990300.1">
        <property type="protein sequence ID" value="SPAL_0000990300.1"/>
        <property type="gene ID" value="SPAL_0000990300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="8">
        <location>
            <begin position="245"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000990300.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="61520" checksum="0EC0B44938B90271" modified="2015-12-09" version="1">MLRNQKVTPIESSDELTVGSYYYILMRSGNENKETIGQIVDIKLADFQEAAMLVPRAYSITSNTTKTTNSASISPCSSADDGPHRPIFDSVDHNDLKENMRNGQIVNNNIKTFENEIIKNEYKEDLSDSMLDEKMDTSSETDVKSDFSDIKTQKKYVYYVHYHGQDRRLDEWVDRSRFLKHIHVSPGADPFVISTPDIKNEKEFFGGTLTRQQKLYQQEFCHVQKSFNDLDATTALLEREHTERTKVRNVEIIRLGNYKMDTWYFSPYPAELCYNHQLFICEYCFAYFNNSLFYKYHMKNECSYRQPPGDEIYRDGNLSLYEVDGKFNKRYCQYLCLLSKLFLDHKTLYFDVEHFLFYILCEVDDYGAHIVGHFSKERGSMNNLACIIVFPPYQRKGYGQFLIQVSYALSSREGYIGTPEKPLSDMGKVSYRSYWWWILLKALDHASSEHVPLHELSLTTGIHEEDIMTTLQPMNLLKPWNGITFVRCGKKYIEHLKTLNLTRPPKLLLQIELLRWLPKIRRDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVX4</accession>
    <name>A0A0N5BVX4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVX4"/>
    <dbReference type="WBParaSite" id="SPAL_0000998000.1">
        <property type="protein sequence ID" value="SPAL_0000998000.1"/>
        <property type="gene ID" value="SPAL_0000998000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="13">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="15">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="14">
        <location>
            <begin position="244"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000998000.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="91295" checksum="0C711676AD1D7CDD" modified="2015-12-09" version="1">XQRPQAELIIKDDQVDVKLNLRTKNKSYVKDEEFCPKDSFVVIRNSQLLCGVLDKSLVGSGSKSNIFYILMRDFGEDVAINAMWKLARMAPVFLSNRGFSIGIGDVTPSKQLLEDKAKLLNEGYTKCDGFIRDLKENKLKAQPGCTSFETLEALILKELSSIRDHAGQACLRNLSKHNAPLTMAISGSKGSFINISQMIACVGQQAISGNRPPDGFENRSLPHFERNQKTPDAKGFVGNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKCLEDLCAAYDDTVRSSTGDIVQFKFGEDLLDPSMMESKDGSMVDYEHCLDHVKNTTPLTDDPLQYESYDKVLKVFIDEANKSIKRPEHQHFKKKFIEFIEKKLSQRKHLYDMPWNCNKHKSLKEITSCKNCNVSTFKKINQLRAYGMSKNECINMVKLCSMKLHRAITEPGTAVGAVAATSIGEPSTQMTLKTFHFAGVASMNITQGVPRIKEIINAVKLISTPIITATLVNDKDEKLARRVKSRIEKTTLGEVSAYIEEFITNDDCFIIVKLMASRIRLLQLEVTMDTIIASICSAKLPVSVKAGQIRVIGKSILMINAPESKNIPSNLAIQYLKNTLKNVVIKGLPNVSRCVIHADEKKGDSYKLLVEGTDFREVLATPEIDGRYTNFNNALFVADVLGIEAARTCIINEILSTMESHGIGLDRRHVMLLADLMTYRGEVLGITRNGLVKMKESVLLLASFEKTTDHLFEAAFFGQEDKINGVSECIIMGAPITIGTGLFKLLFKREKLNPAYLQPSVPFISRKCIENFNIEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW66</accession>
    <name>A0A0N5BW66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW66"/>
    <dbReference type="STRING" id="174720.A0A0N5BW66"/>
    <dbReference type="WBParaSite" id="SPAL_0001006900.1">
        <property type="protein sequence ID" value="SPAL_0001006900.1"/>
        <property type="gene ID" value="SPAL_0001006900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF411">
        <property type="entry name" value="LD23667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001006900.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28290" checksum="3F6DCD87C2BE6F94" modified="2015-12-09" version="1">MTTHNQFDELYQSINLNIKKIEHNVHLLNQVVEKIGTPADTTINESELNELIQRSNALSKSTNNMMKNLVSLSNGNHILKQKREILMDSLMSTLNLLQDAQRKAAVKEKGKINEYELENVNQITTDSSDLNPFSSQQMSHEQIQQKQQQIEEIRQRQLALQQLEEDISDVNQIFKDLAKLVHEQGDMVDSIEDNIDSAQIYVEQGSANVQQALHYQQKARQKQLLLFIFFAVLIFIILLTIWFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW92</accession>
    <name>A0A0N5BW92_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW92"/>
    <dbReference type="WBParaSite" id="SPAL_0001009500.1">
        <property type="protein sequence ID" value="SPAL_0001009500.1"/>
        <property type="gene ID" value="SPAL_0001009500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001009500.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18239" checksum="D7ECBB6289279B93" modified="2015-12-09" version="1">MIINTADLVNIEVEKRVIIAGRVSCNFESSQDIDVQLWEIDKTLVNDVEFKTTTDLDGNFYMDKTVKDYFTDDLELVVKIFHQCNVKDTTICYNVVEIPIPTIFFNHKQDSEESHTPTVYNLGTIELNTNHPIQRRSCSHILGSTINRYIEFGLKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWE0</accession>
    <name>A0A0N5BWE0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWE0"/>
    <dbReference type="STRING" id="174720.A0A0N5BWE0"/>
    <dbReference type="WBParaSite" id="SPAL_0001013700.1">
        <property type="protein sequence ID" value="SPAL_0001013700.1"/>
        <property type="gene ID" value="SPAL_0001013700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001013700.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44323" checksum="C5EE0D0ACC16515B" modified="2015-12-09" version="1">MPEQIQFSSATTTSNLYPLAIQQAETEDSEEGYDCCCCLDNFRFKRTLKAICYGQILSLCLCGTGIGSQYLSEFKVNTPMAQSFLNYFFLSFVYGLGLIFSDGSESFFEIIKDRGWKYLLLGIIDVEANYLVVWAYQFTNLTSIQLLDCSVIPFVMILSYLFLRVRYLTFHIVGVALCLLGIAFLIWADVLENKNGSLGESNKFLGDCLCIASSALYALSNTGEEKLVKNYSRNEYLGIVGIIGFIISGIQLAIFERNNLAEVNWTWKVIAMYLLYSVSMFIFYSMVSIVLQKTSALMFNLSILTADFYSLIAGIFLFHYQFHILYFISFAVVIFGSIIYSIKETEIAGSNEDFCKPLRKIVSNFGSCNWSHRHNTTATTHTNRNESTEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX23</accession>
    <name>A0A0N5BX23_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX23"/>
    <dbReference type="WBParaSite" id="SPAL_0001036050.1">
        <property type="protein sequence ID" value="SPAL_0001036050.1"/>
        <property type="gene ID" value="SPAL_0001036050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001036050.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8850" checksum="DDCF58DC9D4E9B92" modified="2015-12-09" version="1">MMREKKIEEDSGKYTFQFKKKAKTKQEKIIKYFEDDRHAFLLSWRNAREQYSNARSIREVSAKQIVHFLYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX56</accession>
    <name>A0A0N5BX56_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX56"/>
    <dbReference type="STRING" id="174720.A0A0N5BX56"/>
    <dbReference type="WBParaSite" id="SPAL_0001039100.1">
        <property type="protein sequence ID" value="SPAL_0001039100.1"/>
        <property type="gene ID" value="SPAL_0001039100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="643"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001039100.1"/>
        </source>
    </evidence>
    <sequence length="791" mass="92671" checksum="FD92EB10C37F2230" modified="2015-12-09" version="1">MSKTTISTNDNDIINLLENCTDLEVCSKEISTKLSNIHNDVVEDCINQIERLVELHNEINKCDKIFDSLENTLSSFLVQLGTIGYDMQSLQTESTSINQQLDNLHSVRNHLSKFIEQVSISPKIISTITESDCNEPIFTESLIQLQQQIHFIKSQEHLEAKSISEVKVVIENLKNTAILKIREWILIKINSMKKPLSNYQIIQNALLKNKYFYEFLLVNDKRIAKQIKEEYIDTVSKMFYSYFKTYTSRLFKIQAEAATKDDLLGYEDFKPRLISSVLSLGKGVPIKNKTSVFSLAGRHSLLTMDLISPIIVPHVAQQMNESVEFEKIFRSVQYSLVDHASYEYLFSADFFLISGENLIDHFSQVMGKSIGYFSQFFSVKIQSNNDAISLYICICLCKKLRQLLIEREINSFDGYWHSLEQIIWSRFEKVMMNHNESLRNYDFSKAHSNLKKQSNDCIKPHHVIRRYAEMISALIYCSKLADSSADVRLYDILSRQQQEIELFISHYCSQLSSKEKLFFSINNYDMITSVLTEAHCSDARERDLFENLRQECVEVYVEDILKEYFEELVTFVKNTESLMSSDNIEELNKIRGTLKLIKTKEASEREICKTFMKRPILNTVPRAYNDNEMSELFLGNEFEQSITQKERLVRECNAILKFHELRYRAALNFDDYKNWNCYIIGPLGTPYEGGIFFFRIEFDEETYPQKGPRVFFETRIDHPCIHVDGEVRFWNEWWNPKMQALDVFKQLDKLMIDFDTFVLQREWGNFNKGDSVMKERRLKASIFTKRYAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXR8</accession>
    <name>A0A0N5BXR8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXR8"/>
    <dbReference type="STRING" id="174720.A0A0N5BXR8"/>
    <dbReference type="WBParaSite" id="SPAL_0001058800.1">
        <property type="protein sequence ID" value="SPAL_0001058800.1"/>
        <property type="gene ID" value="SPAL_0001058800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895008" evidence="4">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001058800.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18372" checksum="C3995FFB32EFACA6" modified="2015-12-09" version="1">MKLKVLTFIAIFSTLSQIISSRKPTCPRNYTFVSNIKYQCSQKCGSLSKLKCSKKSRNPCVCTGKYALDKKGKCILKSRCPKKPITTTRKPKVPKCNENMVYSKCPKECPKECFQRSSKKCKKSKHCQKPRCICLSGFVLHGNRCISHTECRKLKAQRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZE4</accession>
    <name>A0A0N5BZE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZE4"/>
    <dbReference type="WBParaSite" id="SPAL_0001113500.1">
        <property type="protein sequence ID" value="SPAL_0001113500.1"/>
        <property type="gene ID" value="SPAL_0001113500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001113500.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20480" checksum="B44D0DF78D106A41" modified="2015-12-09" version="1">MYLNDKIVECEKGINFKCILNIIFALVLFFIFIITLCFANKFIKKVFPFLFTTKTKDKRFGSTSTVQTSWSLESRNHSITREGNQEIFEEFQRQPTPTIIVENFEEQLSPSPDCFSSINNDLEYETNKVFEYGLGKTNPHFLRVPSKTTCQFNVTVNDIHDYFNTLKVIRKLNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZS9</accession>
    <name>A0A0N5BZS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZS9"/>
    <dbReference type="WBParaSite" id="SPAL_0001126900.1">
        <property type="protein sequence ID" value="SPAL_0001126900.1"/>
        <property type="gene ID" value="SPAL_0001126900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001126900.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37530" checksum="31A895FB16C2482B" modified="2015-12-09" version="1">MDLNLLSLPLEILAKIFSNIPWNQLINVKLTARKFNFVTKKYLKDMQKPKPCFIEFENDYTHNDGIGRIKIICHIFMINADGIEKNVSLQKEFFLLSSELDHLHIFLKKFDLTSLLSVDILLDDHTEVMRIFSDYLHNANRICSIFVTAKNCKDDLDNTLLFLQKIKNTRFLSLDLYFPHLIVPKDFVIPVKNSLRSIRLHERENTAFVNSRMIEYIVENNPILDGYRLSFNNFETYKMVIETIVKGELSRRNSGCLHKYITLYLSFSSHEVFPELLRYFYSEEFPYIGTDIEDENSFNGDLGCPVCGKFDSIKIEKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C194</accession>
    <name>A0A0N5C194_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C194"/>
    <dbReference type="STRING" id="174720.A0A0N5C194"/>
    <dbReference type="WBParaSite" id="SPAL_0001177200.1">
        <property type="protein sequence ID" value="SPAL_0001177200.1"/>
        <property type="gene ID" value="SPAL_0001177200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF71">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001177200.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39799" checksum="AFBE706790B91E92" modified="2015-12-09" version="1">MSFTRVDFFNTKWVPWNTPLEEKLQLIAVVNFIFVWLILPIFCLWVPFYILFYTSIWWTMPLYFTWYIYDFNTPSMGSRISYNFRNSNLWKYLATYFPVKLIKTSELNPEKNYIIGCHPHGILSIGSFITLCTNGTNFMTTFPGIKSYLMTLKAQFLLPFRREIGIALGGVEASSSSLKYILTKCGKGNAVGIVLGGIKELYDAHPNSNILKISKRRGFCKYAIMYGANIVPMYNFGENDAYDQIPNERTSFIRQIQMKVCQKFGFIPPIIRGRGILNYSYGMLPFQKPIYCVMGEPIEVIQNDTPTEAEIEELYQKYIDCLKKLFNDNKCAYGLSEDAVLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2C9</accession>
    <name>A0A0N5C2C9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2C9"/>
    <dbReference type="STRING" id="174720.A0A0N5C2C9"/>
    <dbReference type="WBParaSite" id="SPAL_0001213900.1">
        <property type="protein sequence ID" value="SPAL_0001213900.1"/>
        <property type="gene ID" value="SPAL_0001213900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895459" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001213900.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34286" checksum="DD118819AE1680A0" modified="2015-12-09" version="1">MAIFFTIIFVILLFKDGMNDSPPNRSIKKNTIFKEFEICESLTEEPFSDFSNRKNNLKFVATKNNECFIECDVISSPKPIINWYKNDELYKSYLNNYMDHTDDLINSKNFKSQMGWSSILSKIEINPYNVGDKFHCEVINPCMNERIISQAYTVPQNASNSCTKNSKNKRYLSPSRLSNMFGIRNYFNVYQPKKVEVPIITAATTMRMEYPGNLITLSCQSEAYPKATNKWELIEGEDEDGIGTSIENIEYLKVLNNGDLFFNTTQIPEDVAGMTFRCNASNSGGWESFLSTILFVAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C688</accession>
    <name>A0A0N5C688_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C688"/>
    <dbReference type="STRING" id="174720.A0A0N5C688"/>
    <dbReference type="WBParaSite" id="SPAL_0001346150.1">
        <property type="protein sequence ID" value="SPAL_0001346150.1"/>
        <property type="gene ID" value="SPAL_0001346150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001346150.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18551" checksum="A0CBD51BD56D7A21" modified="2015-12-09" version="1">MRPGKASGDDGMIDFHIKPIQDIFIPHLLVRLIKYLVDAKNPSAFKKSKLIQLLKSGDVKCLGNYRQIPLLSNFYKLYSLIIFEQLEKRFDEIIGTSQGDFVRNSSCCNLILALQLELERCKEFKGISLYMCSIDFKKAFDLLCRKSLFHILNFYNFPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7D6</accession>
    <name>A0A0N5C7D6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone H4 transcription factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7D6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7D6"/>
    <dbReference type="WBParaSite" id="SPAL_0001385000.1">
        <property type="protein sequence ID" value="SPAL_0001385000.1"/>
        <property type="gene ID" value="SPAL_0001385000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001385000.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="53226" checksum="043ABEE3B9A4276F" modified="2015-12-09" version="1">MAVNNDYENTHQIENPFGPHSWYTLKKIYPSFDSIINDNNTKQTSTNDLFYFKCQWHSCAYQCYTEDEILHHVDDHCKAIENHISSLSTIVCQIYGCRVQLKSVYEFKLHISYHLYLLKLQYMGYKYLSEKVKWNFFDECGFGRQPSEVSDECPLICRWRKCNESFYSVIEFYSHVDRHVNSYPRKRKNDNINYQCQWDNCTEVYDEKFTFSKHVNTHTLSKKCACPYCGERFLESTRLRDHMNRKVKNENDAKYTCNYCCKKFKDKQILESHIKRHYKDYECLICHAKMSCPSTLARHVSNIHGGGEEHKCRRCGKIYYTKTSLKGHEELCLTGEKEVKCPECSAKFEFLPSLKRHFTSVHQKPFTTDLYMCHICEEEKIINEETSSSTTTGTTTGKNKNGVFLFSNALSTHLKDVHKLKVPKGFVRFSYRKCPDTFYRLELTPFSRGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C857</accession>
    <name>A0A0N5C857_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C857"/>
    <dbReference type="WBParaSite" id="SPAL_0001411200.1">
        <property type="protein sequence ID" value="SPAL_0001411200.1"/>
        <property type="gene ID" value="SPAL_0001411200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="417"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1723"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1723"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001411200.1"/>
        </source>
    </evidence>
    <sequence length="1786" mass="209130" checksum="B94F9C57CEB30888" modified="2015-12-09" version="1">MNEGNNCIYCIAADSFLNKSPQNFQVPYLNFFMGERLRIISCNGDWCYGYLDEDPEIKGIFPSNYIFYSAKDFDVTENLNDKDELEHNDESRSLLKEITVTVRNWWSHIRHNFDAVNTSSNYDKAFDIMEDLIVTRKRILSRSIPTEEMREFKNKVHKKIDIVDNILGLEMKIHDDYRKIIEPGTLSILETYEQHVLSYKKIQNIAQDDILTKIKGNFGLFFRFYSTTISVNCDVEIKVSLYDCEKNEFYSECYVFVWNYRTGTFYDSYCQLMFVELDDVCKEPGRVFVVFQVSKISPLENKVPNKRTGNPEVWGRQPFAFGMKDIYSILENSTEGERGDLNFKLDKVWSFDYFSKSDKTLRPERNDAKIELMCTIQVYKGHLNQIRENAFKLFSVNPTVIVPPIRHSEIVWEEDPVNEFYLTLINGDFNGFKVTDKSIEIRIQVMDEKGNTLMNSIEYITPNGTQHKSIYESNVIVGNDKPRWNEFVKLTVKNHYQENIHLRFLFFNRKMNDKAKTERGPFALSFVPLLKDFRLINEGDHDLIVYKLDSAKFEEHDVSYISLPSYRHETRNNPKLISRVSHPYLSSSEKNYFVIHMKMYSTVLTHNPLLINILQWKMNKLDTRKNLKELLCNNDLSNDTEVLRMLPFICDTLFEIWDDMPDLENLVFKALIHVLKATHEPKLRSFDAFFDNYLRSFCYNTAYSKLLNQMIFHLEKANDFYEEVGNILKSLNYLMAIIVSSKICNDFFGTSDNVEFYILIQKFLHVIDELMKDKSVRITTQNRIVQNIASCVPHLTVRGIFDINEVTNFVSTIMDHFGSNIVHREKLNFIENIINSRLFEIDESRCIILPKILVILQEFFSLNFNESIEFDCIVDYIKHSCRITATIIKFLFPYSELEDIKKPGNQEDFMLIVWRILRPINSVIIKLIRTRYEECFLDCITVLYSILDMFSAETFLRYVEEHESVVDAYDMTYEIGSVVADLVTEGGYPKVWKQMYTIQRKTTAKILMFLKEIFIIFFTYESFDEIMWKEFIKCVVILCIKSNEFWHSMEESEREVIRSTVISIRSLWYELPNEHKGVFIPSIVGDLLRVAVIDDEDIRGAITSIFIDMMVVNYYTKGSKEIIDKIECEMIRQLDLMLEENYGDTKFRIDLIYNLKKWGQNDRNFYNLRGQDLFEKLDNLLVLLLEYKFISSGFDCLENCMIKIAQLIRFLDSIQQYDLYVRYIYKLYNINMLCDNKIEAALTLLKHAELLNWSQESLPEYLYHGNVNRNCTTHIELKELLYIEIADLLDAGCLWEKAIEILKELTSVYESIVYDYKKLSLHYSRLSELYKKITTVGRIENSYYLVNFYGRKFPSYINGESFIFRDIERRGAFQTKLINSYGVCEIVNKMDDVSYLKDEEGRYLQIIPVKAIQTSRKIIDSKTISHNIKWYYKYNGICKFEYGKKKEILDSKWTTLENTETTRMWVLKTFVETIDILPFLMPFSKVRIISEPVLSCPLDEAIIVILQMNDDLYETALKVYNNPLESVSTLSGKIRGIVQAFVMGGVQNYNVFFTKECLEICDESEKQKVEELRDLLIRQIVIIEYSLFVHATRSSQISIPFHQSLVDSYYELKRDIETKFNKITESLLGPSDSITISEPSIDKAPSIASMTINSGRETLFKKASQSMLRSPLHTFTSLRSSKSNLYNDDNNTSIDGSNLDKKSMDNCSNMSFDTTIENSTIPTKYRKQSSSSDVRFRKIPSIYSDKSDSQITSPRTSEPPFEGSSNDNDSREQTPLAGKTCLMTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8H6</accession>
    <name>A0A0N5C8H6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Btz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8H6"/>
    <dbReference type="STRING" id="174720.A0A0N5C8H6"/>
    <dbReference type="WBParaSite" id="SPAL_0001422300.1">
        <property type="protein sequence ID" value="SPAL_0001422300.1"/>
        <property type="gene ID" value="SPAL_0001422300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001422300.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48843" checksum="1A27064454D7A493" modified="2015-12-09" version="1">MATKTDNQKIEGQEGEVKEQENKLKKKVSLDDREEVPSDPINYNKDNTHNPDNKSGRVKKNQKDDNKDPTDIPKNGKYYMHDDRGGITKENTKKKVLKNDKEWKHDKFIDEKDISKDNNEICTKNVKDVCKEDESTEKIVKGRGKTRYGKKESLEMDEIIAVKLEKKKSKNQEKKNENNKKTELKNDKREGIINNDVLKNKRQETTMDIEDKKRSSNKIKLKSLKNPKQVRIRERTVKLKNNFKTNVKINRTENGNENDMPKKEVTMETSKNKKEETIGYVKKFEVGGHIITQPIKNSSRFVSDQSSHKNYINNRNTYASKSVRGGYNVRRGSRGGKGNFRYRGQINTTSDAEKSPVTVYVPPETIPYPHVIQYANVIPAAPILPPTGAVYFNIPSTQQLPKPEKRERKILLIAEPSKETNGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C967</accession>
    <name>A0A0N5C967_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C967"/>
    <dbReference type="STRING" id="174720.A0A0N5C967"/>
    <dbReference type="WBParaSite" id="SPAL_0001445000.1">
        <property type="protein sequence ID" value="SPAL_0001445000.1"/>
        <property type="gene ID" value="SPAL_0001445000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001445000.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="75676" checksum="54C3AE3815797B01" modified="2015-12-09" version="1">MYFLYSIYRRSYCDSQSPIKEEDVVMTADVADSESNEANNGSNLIELLKKSQLKIDDVFTNNDNKTIIDDRYKLKTPEKKLLSSTERSTIRVIGQYLFNLGLLESCDALMKESGCSVEDTRAIALRECIVKGLWDEAIEILDDMNEVFKSSEEKLELKILLLEEKIKEQITHGDYCLAFRTLQLEYPSDQRLIKRKIDFVKIMMENKYNDRIPCWCDEGYDQYTKNVQEERRELIGDIQTLLEPDFLLPPHRLNELLKQSIKSQSDDCMYHISDNLQQSSINNSLIYNHKCSFDEFPGHVRTVLHHNYNEILALEFSPCGKYLATTGRSRTSSVYTINDDGSFGGELKLSFPSTIAGGGCISWSSNSECLAIASLDDDRSGVFVYSAKTGYLLRQIWSLPESNEAFTLVSFFPKENSSRLAFADLKGHFYVADFELDHNLRYDVIDGFRMRALICLSDDCSVIAADTHNRIRKYTFDISENHGPKGETLMTFDSPIIHMAIDKSEKFLLVTTRTAGHRVINIETRQNVGTYYGAHITNCIITSCYGGPQDEFIASGSEDNKVVIWNRKKPEPLLYLNGHSKMVNSVSWNPVNSHMLASAGDDGTVIIWTPRKMVPLTGEDHIEYMEGTRVPGDKWTNAKKRVMEKSSKAQLDYFSPEFYGPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9W1</accession>
    <name>A0A0N5C9W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9W1"/>
    <dbReference type="STRING" id="174720.A0A0N5C9W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001468800.1">
        <property type="protein sequence ID" value="SPAL_0001468800.1"/>
        <property type="gene ID" value="SPAL_0001468800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="261"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001468800.1"/>
        </source>
    </evidence>
    <sequence length="736" mass="83501" checksum="86533B105363203C" modified="2015-12-09" version="1">MDRIKDSMNNSVQRIRSLAGPKITQSTAANNPSSAFNKKEFLLTNSVLDIHNTRIGDSLKSIRDVMSKTIKSNVKEDNQEKKKKKLDLHQLAHQFFSEALFIQPYSVGLEKIFKEAGSSYRDIVDNQVSMDMYVEEQIIDKLSKNMDLAKEISKNQNELKKVVSNRDSIEKKMRTVSDEAKSIEYQTDFDSLVNKVDSLRETTLALMFTLKGREYQNAMIIRDFMQQHLDFYEKAAKILKSRIEVVDKDISEYIRQPIFGVDIDKHCQKEGRKIAAPIQICAEVLFENGMKEQGLFRVPGNQNKVKRLRAALDAGAEKEIDDFVHDPHTICAVLKLYLRELPSKLFPKNLNSGYLKAVEMNSDGKDEQLKFVYYLLNQMPEVNRDNIAYLMKFLRNVTEYEKVVNMNASNLALMLAPNLFDENCIDKNYNPNVGAKFCEILITHANVLFTNYDFDYTRRKVTKTKAFGGPYGGSVTSFDSDYAFTENRISSGNGNYNDRFSNNYSIYKENKSKKGPIYHEYDDSIDNNSERVSQGSSVCSFSIDNSNTPSNRYQYEKPSRPTYPPPQRHFKHSSSDSDKITFSTSTGETVSPQLSQKSNFSKPDPKVNVGDTYENYANTYPQSPPLTSRVDSTSSIISGDEGLSYIKKELLSEGALFLPTNLIEVNNTPERNIQHVTNLYPPLNIINSHGGSLLINTGESIKPTISPKPRKAPSPPKEGDNEISNNRLSEVTVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBL2</accession>
    <name>A0A0N5CBL2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBL2"/>
    <dbReference type="STRING" id="174720.A0A0N5CBL2"/>
    <dbReference type="WBParaSite" id="SPAL_0001527900.1">
        <property type="protein sequence ID" value="SPAL_0001527900.1"/>
        <property type="gene ID" value="SPAL_0001527900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001527900.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13569" checksum="6A35CE552B6952E9" modified="2015-12-09" version="1">MAPPTASKGKKAVKSQKAVRPTDKKGKRKARKETYSIYIYRVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASKLAHYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBL5</accession>
    <name>A0A0N5CBL5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBL5"/>
    <dbReference type="STRING" id="174720.A0A0N5CBL5"/>
    <dbReference type="WBParaSite" id="SPAL_0001528200.1">
        <property type="protein sequence ID" value="SPAL_0001528200.1"/>
        <property type="gene ID" value="SPAL_0001528200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="490"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001528200.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="66761" checksum="8B89C0D825C9FF95" modified="2015-12-09" version="1">MTSEATLNIPSKNSDTPEKSDTEKGKMSFVNVLLSGDDTTSKGTIVYSSSTSNNEKPPTDTDSSTTPHEKGPKGRFSNKRRNFKKNGGRNRNDHKISNVDDKVGQSMGGYSDEVFVDCDGGDVSNDGGIISPALTPNENPCFNRKKVQSRNSNIENEVKRHGTSESDYGFNSPTGVSGCVNNQEKKVEETTNMQSKNIKHTQEKQKTPRHHNNKNFDENQNRQLPPTDINDTNSSSTNIRNSEISSNLSNDTGDNHQSNDRNRKKVYSKSIKKNHIPYNGRNKRDDNHQGWRSNRGSTSSLRNKNINSQGSAVFQDYLNINETSVEDQGNGGNRNSGKRNKPYKGRKSREYSHNESDARNVGKQANAYKERGPLPSWDEADACAGNGTEDGEDYMGVLEKEFRNLVPYYTVPLFDETKATEVPSITYVSGECHVLSPKPILPYRPVTISTSIDTYKKSQPLTPITPPSMSHFTFSPQSPLGYGKPRYGCAMSVEQIKDCILRQIEYYLSEENLVKDAFMLSKISGDGYISLPLLAGFPKIRKLTADYNLVVEAMKSSTVLEMSMDCQFIRSRNYKNYWFINDRAIGGPEKMGNVGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC34</accession>
    <name>A0A0N5CC34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ChSh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC34"/>
    <dbReference type="WBParaSite" id="SPAL_0001544300.1">
        <property type="protein sequence ID" value="SPAL_0001544300.1"/>
        <property type="gene ID" value="SPAL_0001544300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001544300.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39430" checksum="26030919B341ED12" modified="2015-12-09" version="1">MNPIVEMNPVPKAIHKILGKVELSVENSREVDSYFIIQWDNNTGPITIQNRASIIDEFNGEIGSFDDRSTMNFFFDRTRERSGIDIIKNDQATFLIDILKKYGNDSSTFGSCEGSPRLQSLSFRSSGVKKKRASRGKKGKKEWLKQVKATGKALMECDMDEEDSLDEFEDVPHYGLIKDDGSTSEKSSDGVASPACSGKKTKHRSAPSPRSVEVSMLRSDDDGDDVTEESSDSDSSQDSDDMEVSVEERSSEPPSPQSCTEEEKYARWEKGIVDRVRADEETPSENRDWNELEVVTSVYSSEDAKEYYLVYNTNNNSTCLVETHEIPDSYRYKLCEFKEMVTRRKRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU5</accession>
    <name>A0A0N5CCU5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU5"/>
    <dbReference type="WBParaSite" id="SPAL_0001569500.1">
        <property type="protein sequence ID" value="SPAL_0001569500.1"/>
        <property type="gene ID" value="SPAL_0001569500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569500.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8387" checksum="B5678652889DC369" modified="2015-12-09" version="1">MRRSYTADLKLKALMFAEIHGTRAAAFKHDCLESLHHQNMPQFCVMACKILVPKTNALTTRPLRLEGELLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU9</accession>
    <name>A0A0N5CCU9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU9"/>
    <dbReference type="STRING" id="174720.A0A0N5CCU9"/>
    <dbReference type="WBParaSite" id="SPAL_0001569900.1">
        <property type="protein sequence ID" value="SPAL_0001569900.1"/>
        <property type="gene ID" value="SPAL_0001569900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16206">
        <property type="entry name" value="EFh_PRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF196">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="626"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="714"/>
            <end position="840"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569900.1"/>
        </source>
    </evidence>
    <sequence length="1131" mass="128492" checksum="EA7C3300DA4CF67D" modified="2015-12-09" version="1">MSQSARTTFYSIPNVTSVSGFLSDRSSLNNSNCSQDSIQYNASSCDKNLPSSSNISSTDGNPSPITKLDPFSNRPHLRSSLRHHTSRAAKSPGRKTVSFFSVNSDKKVSNVSDCLQIMQNGTEMIKIRTHVRQFKRFFSLDTDCAYIRWQPSNKKPHKARLSVESIKEIRVGRNTEHFRGLENQLQDVQDDCIFSIIHGDNYECLDLIALSAEDANIWVTGLLYLTSSTRIKCLPNNIIGPRCTLRERWLQSVFIKADENNIGFLNEKTTIKYIRMLNDKIAVSRIKQKLKEVIVSQEEEFRGRISMGEFVDIYKDLATRPEIYFLMVRYANKDYLTVDDLQLFLETEQGVSEATNEICEEIITKYEPSDEGRLNLLMTVDGFSNFLLSKESSVFDPAHLKVCDEMDHPFNHYFIAASHNTYMVEDQLKGPSSVDGYISALKRGCRFIELDLWDPLEIEEDAQPMIHNGPIASCRLPLSSALRVIKDLAFEVSKYPLFIRLEIHMSLQWQRMAYEMITETLGDLIYKPTEDVKDWTDEKNVPSPHKFQNKILFVGKKFDTMSDVGEVSEEDEAEEMHQATGNTKRSHKKKIYILKEFSDLIPNFLQSCLVTDSSLLSNNELNKKNHLLSINEGDCLRIMQNYPSDLIQITKDFLVRVVPDPLRIDSSNMNPQEFWNFAVSLVSINYQTPGLHYDLQEGRFSSNGFCGYVLKPSTMREDLFAPDERLAYCAQILHLRILSGQQLPRPRGSNVKSDSADPFVVVEVFGIPLDCAEERTKTVRNESANPNFDESLQFQISVPELALIRFLVLDDDFIGDDFIGQYTIPFECLQSGYRHIPLLNNEGDPIENCSLFVHIAITNRRGGGKAKKRGMSVKRKTAKVQTGMKLVGIKSVDELFKSAILPLIESIEMRNKMETALIEWQEQCGLSATGSIRQGLRLMYSRICSLNTSGTTTDSPQTSARLFYKDGNNMSKNQGNISFYIQPTANGCPLIIRTGIIPDSLTKTFVLMECLFEKCSIILNKTENLLNKIEDATKKISECYEELPELCVQAGLRSQKATRATENFAWNVRLLKSQLASMHKSQIEASDIFTQVFDTARLLGILKTNDDENNDKEFVKKLSNDLDEGINDVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCV0</accession>
    <name>A0A0N5CCV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCV0"/>
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        <property type="protein sequence ID" value="SPAL_0001570000.1"/>
        <property type="gene ID" value="SPAL_0001570000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="72"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001570000.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17879" checksum="2A0B2222A207E6A6" modified="2015-12-09" version="1">MASNAKKEQHLKAQYIDGSMKLTICRSKRVGAYNQLSEKQNCLYKELPEELADDVIDQITKEHELKMATRFNKKLQEEQEHLSKGIETLENEKRTFESNVEESNKRITSLAGTLGGINEGIKKLEEQNMTITEELRKKVQIAMNVLRPQNQKITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCX3</accession>
    <name>A0A0N5CCX3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCX3"/>
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    <dbReference type="WBParaSite" id="SPAL_0001572100.1">
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        <property type="gene ID" value="SPAL_0001572100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="85"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001572100.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46855" checksum="6075D10F6811580B" modified="2015-12-09" version="1">MTPRICQRGLRKTINKEGKSNMVLTELSDEGYISKPSSIDFSSVIPEYETMKDIVEEVASVYNASIHHFCEATRNTLKEQRENLKNNVSQENSEIKIPKSPKGDKNVSKVDKTRGTLGIRKGRVTKKNNSFDPETSFSTNGTSGSRTTAALHPKVKSQANGTMGLRRNSKNVASASCRVQKVKKRNRDTTERAILLAQQGSGLRRADNKKKNLLKEKAERAKREREEKARQVEERRRLKEKERKGMFKEIKEKVEHVKEFRNRVKAPGSSNSQRSGTPISSVSPPEISNEDTINGTFTLTTTKIGTSRSRDRTIVDKSYGDSELVYETPKQPMGEIEARISKNRTIVDKSLEDSELIYETPAAPRKRRRISSLEDEASFNPPRKNGRVSDCENATPNVTFNCYKANTLNADISLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCX7</accession>
    <name>A0A0N5CCX7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CCX7"/>
    <dbReference type="WBParaSite" id="SPAL_0001572500.1">
        <property type="protein sequence ID" value="SPAL_0001572500.1"/>
        <property type="gene ID" value="SPAL_0001572500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000081">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000275">
        <property type="entry name" value="Si:dkey-30k22.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2052"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="46"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="163"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="263"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="368"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="498"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="694"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="795"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="900"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1318"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1421"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1528"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1623"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1722"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1833"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1934"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2121"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2128"/>
            <end position="2141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001572500.1"/>
        </source>
    </evidence>
    <sequence length="2302" mass="261272" checksum="C0BC7A4E80C4BF71" modified="2015-12-09" version="1">MLLDYEKTKRYHLVVYGTDEIGRNASTLVKVILQDVNDNVPIFEPKIYNITIDVNELTNEGNIKHYDINDNLVKVLASDKDEGIYGDVKYEIEKGASSYFLVDNKENKGDIIIVRSLKEYLKNNLTKSFAVEAIDQDNLRSNEKAIINIIGIDKKGEVIPKFTEKLYTFDVSEDILPGISIGQVNLQNTNDEHYFEIYDGNENGMFSIEENDGSITVSRYLDADHKDSILLNIVAHSKKSQIKVYCQAMIYVIDENNNAPIFEEPLRDVSVPENFPLHEPFFSLQARDKDRHENGKVTYEVLDSQPPCPVIIRPLTGELVLAASLDYEEIKEYNIKIKAQDQGLPPKYSTVDIKLFVTDVNDNAPTFELSLYTASVNEDTEIMSEILSVKAKDLDSGRNSKVVYSIMKDYTKVDEFFGINQNTGSIFLRKPLDRELNIEYSLTVQAIDKGTPPLNSTTTVKIKVLDVNDNAPNCASIISPFYIIEDDNYDDKKEKKDIPLGKINAYDGDEGDNAVIFYRLQQSNENFEIRRSGDIYLRKKPSEICSSSPNHIISIIAEDNGIPSLSSVCLIEIKCEKEKSSIVLSEPFTKILYIPSKCLQKDGCFLTKINGTNIHSIVIEKEVITNFDNYFIIANGTELWIRGGSEINESTLLKGNNRLNLSLYDKNKKKKRINFIIKSLYVEELINGNKKSNKNDTVLLKLSEKLIVGTKLVTLEKRNDKGKYYYKMVTNNPHFTLNENDGSIYLSKPFNYNDQQVHEVRVKRFSINDEFEDLNNEMSVVIDVQNENLYYPIFSKALEIFNISENASPGFLVGRVNATDYDNGVNGAIEYKLHRENDIFSVDEITGEIFLKQKLNYHTMNQYVLVISASDKSKNIKDKKQALTTVIIYVKNENNHVPIFVSITNVSVSENQLSSEPFHFVSAIDKDVDYGKVFYEIDNNENFRIDNLTGALYLISRSGLEKQYVTVKAYDNGNPPKYNLQKIEVHFISTPNKWIYFEKSVYRFNVDKIVGKEHVTLNSFKQRSSDKAKENVKFKIYPEIDEIKNIFSIGYRDGILKANKRLMNKKEYEFNVYAYSENDVKNSDWTTIKLEVENVDIEDVVPLNIVSSSCGNVTIPENMAVTNFKRIYVINGNNENLNFKIEAGNDGGLFSIDSKLGTVSCKELDYETKKEHLLIISVTNMESKPPRGDTCAVRVFVVDVNDNVPQFPHNMNDTVTLLDNTPINWSFMRLEAKDYDTGRNSELQYSLIEDEKGIFDVLSDTGDLILANLRHIHEKEWSITVGVQDNGAYRILSSTRQIRIINNRTNLSSNQSTPPLFLRQKYIGYVSESLPKGEFVMHLSNDAFNTHSLKEAPISYSIVGGNRDSAFEIDNMGRIKTAKELDAEIEDQYLLNVIATNEFSKQFSTMVKIHVLNINDNVPFFPNQRPKKISENTPVGTLIATVTATDVDDDSFLVYSINPANEYFEIEQFTGAIYLKNILDYEVIKEHNLGIQAFDGEHISRTNLKIYIIDENDNKPLFVGGSFQQIFVADNSPPNSIIHTIIAKDIDDGDNGDVRYKIINEESDYFSLNEKTGVLTLLKTLVEGTHYIMSVMAEDSGIIKQKSILTLKIQSISGKEMRIPTFKEKTLNLTVNEDTPLFETIGKLQLTEGYVSPIDFVIKDTESAKMFYINNQGFISPKRKLDRTVQKNYTFNVYMSKYSEAQPILVSINIVDINDHSPVFSRNSTKIIKLNEKILKNSVVGKVIATDEDEFRNGQITYSILSGNYYNTLSINSDTGGIIFENWNEEIFYQERTNNHDLIIMAEDNGTPSRWATTSINVQYDMKNWSGIIPFFVMNCYTFYVPENTFINSIIGSVKATNKLGYHGDDWSYSLSNNPNIFGINVISGDLILKESLDYEKRINYQFNVVVKDSKDRTSIVEVKIFVTPVDEYSPVFSKSSYTFQLSTEAEVGYVIGTIKATDNDKGNQGKIHYSIYGANNNVRMIGIDPDTGVLLLRESMKNKLIKGNKTLEHFIVEASSSYTQTSRVNVYLEIGNFDIINNTSESYGTFSYQGVLILSIISSIILTVIIILCCYRLCRNTPKQSKKLPPIGVNNFNSEKTNNISHLSDHFGNSPNYNKFTMQAPPMPLKSSNSNSSQISSSSNGYKEGALPSISYRFPITNISRDRSHPDSGIDPDVLSINSTVTEYLSNIGITPLSKFMDTSLPKNKYSFMRNSNLQEFPDFMYAKVDEVLDSTNDITSSNFRASTFFVKKPATITNTITPSIPKLNNYNTYCDNSNNDPAMPQFRSLGEVFSEINKVKEKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD17</accession>
    <name>A0A0N5CD17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD17"/>
    <dbReference type="WBParaSite" id="SPAL_0001576500.1">
        <property type="protein sequence ID" value="SPAL_0001576500.1"/>
        <property type="gene ID" value="SPAL_0001576500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001576500.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61671" checksum="A825D55CB4C05001" modified="2015-12-09" version="1">MSKKWSFRSKTKSSGPKTFWNNRVTRAIASRTVSLRRNKLNESYTGRPRRILTARRRLPLRIPITSLSIPDHLDNEENVVVLCEPSNHNIIAKDESYEKIWPALSNIENNMILPSNLIPSNMRLVNVNHFLNFRRDFIFSINVAEKLMPLLAVLDGIAAIKVDKTKPQVFGNFLEFTDNLSKGSLSNDSIKPLLSPLESISSTKIEESQTKFFADFYEYIESLNKESQKCEEIKELCADLANLSQVVVGESDSIKLGEFFAGIAELEDQANSKTYIVPLLASMENISRIVFKESNSHLIGELFNGTDNNEANNNSVTLLPLFDSLEQITTITQNKSNIKVNSAVSCENQEKENNLFEGIFNDSTKNTSDKQIQELKPILSAIESITASQVKASITSMVGEFFKYISEINDKQNKHQEHNLKLASSSLENVVSRMQQSLTNFSSMDVGYNTCSGQTDPKTIETPLAPMRHRAPCPSATSICSCTNNVFMCPPIQSRELLSDAQFYAMEENTILQRINELETQITSMTILQKRLKIYYEFLKQHQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD18</accession>
    <name>A0A0N5CD18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PolyA_pol domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD18"/>
    <dbReference type="STRING" id="174720.A0A0N5CD18"/>
    <dbReference type="WBParaSite" id="SPAL_0001576600.1">
        <property type="protein sequence ID" value="SPAL_0001576600.1"/>
        <property type="gene ID" value="SPAL_0001576600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="45"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="11">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001576600.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39054" checksum="0B224D21F01BC656" modified="2015-12-09" version="1">MKEVKSINPITPKTKHIATNNFKELFTPELIKLSDLFKQSGYEIRIAGGAVRDLLMGKKPVDVDFASDATPQQMIDMFTKENIRMLHKKGEEHGTITCRINDKENFEITTLRIDVICDGRRAEVQFTTNWQLDAFRRDLTINSLFLKLDGTVVDYTNGIEDLENRRVVFSGDAEKRIQEDFLRILRYFRFYGRIADKPNDFDPNILDSIKRNAYGLGDISGERIWTELKKIAVGRFASPVMKVMLEECKLNKYLGIPENCSLDHFEKVVTLNDINDLMPATSISALFSNNDDLMRFHKRCKISNAEKGLCEIIINSRDYLEEKLNDDLLYLVIIYLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD94</accession>
    <name>A0A0N5CD94_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD94"/>
    <dbReference type="STRING" id="174720.A0A0N5CD94"/>
    <dbReference type="WBParaSite" id="SPAL_0001583900.1">
        <property type="protein sequence ID" value="SPAL_0001583900.1"/>
        <property type="gene ID" value="SPAL_0001583900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="36"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001583900.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32197" checksum="2DB59AB812F692E6" modified="2015-12-09" version="1">MSVVEGDKNDDVSTPAELGIEADIVDSDYKLGNDYVVNHHISFEYSLLVRKPIDGLYIIPSANDPFLWFGIIVIRCGVYTGGIFRFRFYIPKDFPETKAVPKIQFELNIFHPCIYQKTNYVNLQRFFPDGFKPNRHRLYHVLNYLQKIFFMLDVDITSAANPEAAILWQSDKQQFKKLTSEIVRHCRAIVYDPPNEDDPNAIQFVPWNEEIYGPIRRLMFKPLNKQNNSPKDQASLSAILLQHSIGGSIPIHLPKMRPNKGFSWINTETMRSLTDLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDG1</accession>
    <name>A0A0N5CDG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongation factor 1-beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDG1"/>
    <dbReference type="STRING" id="174720.A0A0N5CDG1"/>
    <dbReference type="WBParaSite" id="SPAL_0001590600.1">
        <property type="protein sequence ID" value="SPAL_0001590600.1"/>
        <property type="gene ID" value="SPAL_0001590600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001590600.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24148" checksum="C2CE6A37C0F16873" modified="2015-12-09" version="1">MSVEALLSEVTPFFYNTLALKAGVATNVSKPCSSGNSTEDIKSVKASQEKLAVEIQEIKSLIQKLSLGGVCPSTSKGPEKVEEKKEAAKDDEDFDLFDSDDEDEDEAKKKITEERLKAYHAKKSTKPGPIAKSSVILDIKPWDDTTDLVKMEENVKSIEKDGLVWGGCKQIPLAYGIKKLQIICVIEDLKVSVDDLIDQITTDFDEYVQSVDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDH3</accession>
    <name>A0A0N5CDH3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDH3"/>
    <dbReference type="WBParaSite" id="SPAL_0001591700.1">
        <property type="protein sequence ID" value="SPAL_0001591700.1"/>
        <property type="gene ID" value="SPAL_0001591700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF43">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001591700.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21474" checksum="3073DBDF2CAFFCEE" modified="2015-12-09" version="1">MNKGKHPMMEMYFHFRINEVILFENWMPQNVSVYVLSCITVFAMAFAFEILRLYRISLMKKELSSKKCCRAGICNSVNEISQIPNEEPPECDCNVADRSAITHNNEIHEHSTFPINTKVLSSKYHYSLTFLYFIQMFWAYSLMLICMTYNVPLVLSVILGHATAYFILSPFTNMEMEEKVGDCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEB4</accession>
    <name>A0A0N5CEB4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cathepsin L-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEB4"/>
    <dbReference type="STRING" id="174720.A0A0N5CEB4"/>
    <dbReference type="WBParaSite" id="SPAL_0001620400.1">
        <property type="protein sequence ID" value="SPAL_0001620400.1"/>
        <property type="gene ID" value="SPAL_0001620400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018575304" description="Cathepsin L-like" evidence="8">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="10">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="183"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001620400.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45344" checksum="C43B8290A38F6D75" modified="2015-12-09" version="1">MKKLFQIIFAFILIAALIEVNCGKINKDSVDNQEYLRSQYLVTDDDDYVESSEEVDQVAKAIKAGHPDRENKYSDRKSSLESMMKQGLEDWELFKQLHNKKYAHEKIENERMFTFLTNQQRVREHNKRFLNGEVSFEIEMNHLADLPFEEYSKLNGFKMPKEGLLGATKSNASQWLPPLNVQVPDSFDWREKGYVTEVKNQQACGSCYSFSATGALEGQHKRVTGDLVSLSEQNIVDCSTSYGNNGCNGGLMDYVFEYIKQNKGVDTEESYPYKGKEGKCHFKKRDIGATDIGYVDLPEGDEDALKVALATQGPISVAIDAGHISFQMYKKGIYYEPKCSPENLDHGVLLVGYGTCPEHGDYWIVKNSWGTTWGEKGYIRMARNKNNHCGIATKASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEN5</accession>
    <name>A0A0N5CEN5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Scavenger receptor class B member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEN5"/>
    <dbReference type="STRING" id="174720.A0A0N5CEN5"/>
    <dbReference type="WBParaSite" id="SPAL_0001632300.1">
        <property type="protein sequence ID" value="SPAL_0001632300.1"/>
        <property type="gene ID" value="SPAL_0001632300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF55">
        <property type="entry name" value="SCAVENGER RECEPTOR (CD36 FAMILY) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001632300.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="66049" checksum="A5973F2D5E802936" modified="2015-12-09" version="1">MTIEEEDYQICGKPTKCQMVWFILSFIVLLISIGLWVAFPFIYKAEVKENLILKENVDGSYPKSTFYWANPPSDTSMNFYIFNLTNGDEVEFMGEQPKIIEIGPFVIKEIEKKKSIEFMNNQTEVYYKNYKTFIFNEEKSCKFCSRHDKIHYPNIILIGALAQLADPSKNITPILQSVLSIGIHLIGEFSFIDVSFDDIMFNGYHDNLLTFGNSDLFKFIDNHFGKNGSKLLPFDIPNMKKMGIFYGYNNTNDEDYVIKTGKDNMDEYGKILTWAGSKTLPQSFWSTQNARMINGSDSGSLQHMEIKKSDTLPQFNSYLCRSFDMVYEEDGVVSDIPAYKFYVPYDNYDTTLEKNKGFRYANREKINYFPQWPKCDNNNTTSKISDDCSTIDCTIGPNLCNSCCNGSFVDGTYLLPPGMYPIGCYPGRAKAPPFVLFFSAPHFYYSPPEVANALYGLRPNKKEHQPIYYYHEPYSGQVLNVNYKFQVNVPIFGYAPTIINTQMPNNIIPIFWASVQGKVYDNLLSQLWLGFVFVPKLMFILKIVTLVIAILIFALVVIRRIYVKAQNQRKIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CES0</accession>
    <name>A0A0N5CES0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial ornithine transporter 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CES0"/>
    <dbReference type="WBParaSite" id="SPAL_0001635700.1">
        <property type="protein sequence ID" value="SPAL_0001635700.1"/>
        <property type="gene ID" value="SPAL_0001635700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000146">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001635700.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32560" checksum="A6C82E6C628BC04A" modified="2015-12-09" version="1">MVVEEVEINHFKDGAIDLISGTMGGIANVYSGQPLDTVKVKMQTFPKLYIDWKKCFRDTYRSSGVRGLYAGTVPALVANVAENAVLFTAYGYCQKIIANLTNKHDVCSLTPIENASSGALAAVFAAMALCPTELVKCRLQAAKEMNPNIKRTTLSVCRDVWKESGFKGFFIGLTPTLAREVPGYFAFFGAYETCRYMISKEGQSKDDIGIVYTALSGSIAGVTLWCLVFPFDVIKSRMQVQGESSFFLTLKDTLRQYGPAGLYKGLLPTVIRSFSASGCLFLTYEYTKKFLNIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF74</accession>
    <name>A0A0N5CF74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF74"/>
    <dbReference type="STRING" id="174720.A0A0N5CF74"/>
    <dbReference type="WBParaSite" id="SPAL_0001651100.1">
        <property type="protein sequence ID" value="SPAL_0001651100.1"/>
        <property type="gene ID" value="SPAL_0001651100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001651100.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24611" checksum="F73216B0AF1CB07A" modified="2015-12-09" version="1">MTTQASGINAKLPPVSYTKAIDIWIGACLTFIFGALLEFAWVTYISSRSFYKCKVFFPASLFIIILAKKPDNKNLLLKYQTSLPTHTQNQGYSNTTTSLLIPNNGTMMCVTPDPSDIWIKQNNLNPASINIPPNSQNEVLLMYDAKKQNNSHTTKIVTLLKKFVVINWLSKKLDIADRAKRADYISRFLFPFLFVLFNIMYWTTYTRYKADNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFL9</accession>
    <name>A0A0N5CFL9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5CFL9"/>
    <dbReference type="WBParaSite" id="SPAL_0001665500.1">
        <property type="protein sequence ID" value="SPAL_0001665500.1"/>
        <property type="gene ID" value="SPAL_0001665500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="682"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1266"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="2169"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="2716"/>
            <end position="2882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1866"/>
            <end position="1885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001665500.1"/>
        </source>
    </evidence>
    <sequence length="2991" mass="342199" checksum="483363CD4F732C59" modified="2015-12-09" version="1">MLFVGETTQIKIFYFCINVYWTLYFTWGKEGQYWGLMRTEEIKLCETILNGILEIFGVKKENLGEGVYEGIIEALKNDLLTRKPEVVAKKTLELLGEKSILTQKQTEEALKTLEEEVEKQDKAKVDSGENMTETAQRMATSPKLMAAMMKLEPTSSNPRLVNQWFEEFEDRWTLSYTDEERGRPENGELKLVHLRILYGIKVRTFMDGKADELKDTYEKAKNWILKRFGSDAREEEIDKLVNFKIRVSDPEQFNEDTQKFRDLIEKAYGDVKEKELLNRLGGMLRGDLQTMFFTYLASINSYDDMVSKLIQYMNIKGPLKEKKFKNINRSTPMKKDVDKDDESSWMKKKCYQCGEMGHIKPICPLLKAKSDVKIERTSKASENDKDKRIEELTQMVNKLSRLVNEKEYSTNICRKLEVKEEKKLDDDKENAKVPEKRIRTRKGEDLAITRDATRRFKEFYVLGTLMKENKKHEITEVPVTCLIDTGSTRTIITESVYRAVTKKEACNLTPISFNLADGSTWSLMGVADVTLKLGQLKVKVKVAVCQDGDFNFERNQTRYSVMVGSDLLTATNACINYGTEEVTLEGLLVPSLVEIQNSEKNEIRNVFRITNEEKMFRSELEKEFPQAISKSKYDLGRCTIHAPKMEEIAQYPKVVRYKHSQENALAINEEIKKLCKVGVLKECMHPSIVLNLTVTVKKEFVEVQEENSQGAIEVKSVVKKDKRICLDARPYNKVAQRANVSVQPYKEVFQKLRLAKRYSTIDMRQFFYQMPLHESDREKLGVQDPITGIRYSYQCLPFGLINSPSYAQSIIEEIIKRTEFVNEEGKSINPKLYYVSSYLDDVLVSSMVDSDEFHKLIVRCFMRSLSNHNIKCNFAKTTLLSKKIVYLNFCLENGMVSPNEKYIKCLESFPRPETRLAVKRFLGMVSYVHGHLYNVAEYMAKIYKAIQQNKICWGEEQEEAFLMIKKSLRDVCHLHMGDPERDYVMFVDASKEGEAACIGQFLPIDVNTKLWMERESCPKKFRKYEVDFIKYKYKGDEEVRFMPLGFYSKRNKDLTPQSATKLELRCLDNALAYFKSMVNTGRQLIIYTDHKNVINLLSGGTDAQKYMRHINRILTYGKGLTVRYLEGKENCIADTLSRGFSRAVMTRKYLVDVNFNDMEVSVADKCERVDNQLESREKLIEAKFWDRKLSIPERKLCLFQELHDESGHTHTLAKEDELRKRIDVSNEIDYETIKSEFKKYVQACSICKERNDEPKVKWHLNSECFIATAPLQIVQADVLGPLPITERGNRYAIIWCDVVTRYLGGAPLSSLQTECILKGLEDSLYYVFGRIMYLKCDNAQYFISLKEILKERHGTQMILGIPYKHTSQGVVERSIKTVEQLASKMALELKLDSKVDWDNILAGVLFHINNAKHSTVKESPFYLLHGFRSPLKYDLNLKEESLEQLNMLVDRQSELEHKLNYKVAQMLIRQERDRCNKRDDVVSAEDLETEELEKPKAVKKKIPKKVRKLLPGTKVRVYFPKKDKFDATWKGGYVIKRRSRDGRTYEVSKGGKGRYLIRDINHLKLEEGGSEDGPLGYHTGSVRHSKDPDHYIILDQSDILRIQIITLLESRSLACDEGTISLVLENVPPKAFTSSCESRVINLISSTIDRLLEDQSPSSSDTSQGAEDEEISLLIDRFESSFKDTIFVTGPSTDMVANWEGQSEFDSAKNTKFSKWIDALELRFNLDDMNETTHAPRMLTILKLKVGPLGRETISDAQATTYALAKEALKERYDYKMSVEAAIMKLSMTRVDYTPDKFGESVRAIGDLICATIPNLPSSSKLDVVSQRLLSILKGSVQRRLLDRLGFYKSLNDLYTDLEFNNQMSNDFNNGRRPLQPRNQNLQSQLSRNDSIRCHHCNFPGHKKAQCKRFAKGLPKADYTVERKDRPDAPKTTCAVSTPSTTSLRPAVVMLPINGLPTKCLIDSGSAISLIHFNNAQFFASYGCDFKITGATGVEETIKSYSKLSVNVGTKTVTVHLYHSKSSVVLEKTILGMDFITQVSPTTITSEGIVLNNQLFKYAENLESTISAAVDMAREAFPVRSLCNMVQVNNTEIVPEASPLLSNEDVLAKITERYGDEGLYDVFSMDKTDIGQCCEHVPYIAFDYSKVKPFRPFNFPTRLMDQAELVIQEMIDSGTIEEAPAKLLHNLIPVKKRDNTIRPTTDMRRSNDAAPNFDYPVHRVDNAVQEAAGGDYYLLCDLVSSFHQFRLHPDNVGDIGIFFNRKTYRYLSLPQGFKLSPQLMQSILDSLAIPGLRWYYDDGILKTVGTLDDHLERVRNTLLMLKVANLKISWKKSILCSSTINYLGHTISKHGTQVSESACKAIMNLKTPTCASDVKSLLGSLSFYCSYVSNFANKMLPITALLKKDTPFVWSNECQRIFDDLKSGLCSRDILYTEIKDLPLEVYTDASQTGFGGYMAQTIDGTKRILRYWSKKRTHTIRQRDSVFLEGMSIILFARKHLHYLLGAKILWHSDNLPIIKYFSKNLDHHPQLSAWATELSVLDITWKYLPGPSNMLADTLSRLMVDENSNGVTSSDCTDFGEVDDNPSVDVAPILISKVGEENVSDIFKERLKEEQKKSTAQLDPNQILLNDIIYCKTRTRFGDKLLPLLPKSLYKETAQYLHEKLGHPGIQRTLNTLLDCFRAEGIRATVEEVVNNCNNCQVAKPSLLTCPRYEHVNIPSQPLTSLAGDIWQFKSKNESISLLNFIDVTSRMWFPIPITDEKSQTIGDAIITDLFCRYGIPRNIRFDRQSSLRSQGLLSLMKSFDVNVEFGTTQHHNGNTLIERSFRTLKQMLRSAYYDYSDKSPISEIEFISLAISQAPFTVFFMRDSGLVNYKPLLDIDNGTSFFSTTSVLNNWKRIAADSMDLRDKRNATLPNAENEVTTYAKDDLVLLQNPSPTNKLDTPFIGPFIVNSQKDAHLFIKSTDKLRGRPKKVHVSQVKRYIPDDLHDVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG03</accession>
    <name>A0A0N5CG03_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG03"/>
    <dbReference type="WBParaSite" id="SPAL_0001678100.1">
        <property type="protein sequence ID" value="SPAL_0001678100.1"/>
        <property type="gene ID" value="SPAL_0001678100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001678100.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24083" checksum="7EEE111CAF03E489" modified="2015-12-09" version="1">MSAFTAIPMTTVSSSNDIDVFQGEGTLNLPRRWKDKRVPVHHYHSHVRASHRSCDKRKLREKRKSYINTAIISTDGTTSGDDGENVIIEFQNTVQTPLKNNSLLDTRRRENLTSDLEADCEDNNSTDADALSQTGSFRDTNSKTTNDDRNRILIEDTTIDVPNNEEFVNVTDNIQFLNEKIKNLELQLESVLKHNIMLKEENEILKKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGD8</accession>
    <name>A0A0N5CGD8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGD8"/>
    <dbReference type="WBParaSite" id="SPAL_0001691600.1">
        <property type="protein sequence ID" value="SPAL_0001691600.1"/>
        <property type="gene ID" value="SPAL_0001691600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896064" description="glucuronosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001691600.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="61136" checksum="B61EEFD8F98265A4" modified="2015-12-09" version="1">MIFPIILISSLIISSLEYKILVYNPIFTASHIRYMNNLADLLQTAGHNVTVLRAPMNPYNDNIRAKKAREVEPKVRSKIIDEKAEILESFAKDSWTHRNTENPFNIIFELFGLMKWSIEACEYVMDNKELVDELRNEKYDLGIVEAFIPCGLGVLKYVNISNHISVMSGALYDSFYSKFGLSFYTMQIPSVTSPFTPEMSYKERIYNFCAYIAMEILYYNHIIFGNKMLSKYSEIEGIDLDEELRTSAFVVSNDDPILSYSTPQCPKILRLGGLLIAEPKPLNKDFDEWLNIRKENVVISFGSVAKSSLMTDEMKIGMVKIFKSFPNATFIWKYEEDRPKILNGIDNVITIKWIPQIDILNDPRVSLFVTHGGMNTLNEVAYFGVPILAMPLFGDQPRNSKMYEFSEIGKSFDKKDLVENIDYVISLFKELMENPKYKKNAKRVSTLIQNRPYDLKETFLRHIDFAAKFGNVEELGVYNKNLPFWKYTMLDVYAGFCFVIILIIYALYRIFSTMQLMFSFVKSHEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH53</accession>
    <name>A0A0N5CH53_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CH53"/>
    <dbReference type="WBParaSite" id="SPAL_0001717500.1">
        <property type="protein sequence ID" value="SPAL_0001717500.1"/>
        <property type="gene ID" value="SPAL_0001717500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895969" evidence="5">
        <location>
            <begin position="19"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1723"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="624"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="791"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1357"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1899"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1456"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1480"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1506"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1529"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001717500.1"/>
        </source>
    </evidence>
    <sequence length="1920" mass="213737" checksum="ABCDF273FE689099" modified="2015-12-09" version="1">MKLLFYGILILYFTLAKGNIRLLSPVSISEDFDFSKGSPVNAKCHDLTEKDTNTETIVLGETFNVSWIDLAKLKGLYTVEVLDFDTYDLKTSIPLKTITPQSNSDSHIFTSSITFNKDLEECEKCYLRLVQTTEEKKDTEPLNYISCSLVKLLKNPETNQAFKTTDKDCIENSDCLNGGKCDADNKCFCLNGFYGKKCEESNDSDNFKKSFQPKEYEEKDFVEGGNKLYWKFNDNNEIQFVLQFPVNSWVLTGIRPFDYKKTCPTINYKDTAFKLDSQTTKKPLQKIDVKLNTTNLCKENEVMFDCPEISRECEASCDWTADPDSIPKCTKECGKEPRCVCKDGYVRAGNLNDTCVPFSQCQEEVEQECGKNTTFSKCGVACEPTCENMYDVKECLSDCQSPACTCSDNYVRHNGECIFWGDCPNLMVHLSNTTGESIKPNFVERVKAKNNVLSTTTTLSPPNVPVPSGKDEVNGDLHCPVNETINDCGTICEADCLTIFVREQCTDCGEKSCACKQGYARLNGKCVYWGDCPLTTEQVAATKGLDLTTIASVPTQEDSVPARAQAIKTVTSVNNGEKSSVDKLRELKKPSFADTEVMEDEAEVFGDDCFGEFRYPAGCLSGDCDYRLSWNLDDLTDNIEFSIEAKMSTNYWTGVGFSKTGHLADSDFIGITSINNNLKVVDLHTDTTLHPKIDKDQNINKFHGEHMNGILKAEFVRPRTSLFGNKHEDAQFTDNDCFKFIFPVAGKELENGNIASFPTAPIVSENEICVKKCKECVREFKYPQGCEGEECKYVANWNVDKISGEVEFEISSKGIGRWTGIGFSKDGSMANSDMILGWVYDGEGFVTDRFSFNKDVPVIDASGNQDVYIVKGDIEDNTQTITFRRKIITPDTKTDFPLNECYYFLYPVSGGRILATSVNDYKNPKTPILAHDTTPIVSSEKICICGSEIPTPKRFRRQVSDPFKSKIPATGELPPMPKENIQFFEDPLRCSDVVLISSNSDGLTRVKDYYALSSSFVRPDEFYGGEQSLDNVVSYVKDNIVTVSFSRKLDTGDFTDQPINLNNNQPMTILFAQGILPNPEKIETIDLDTLVSNGGAPGTDTKLYVFGKNFTSTQKPKENKETKKPELTQFKDESEKVDDVFSKTGIVSVANASGRVLPKAVDDCDDYFKYPPSCGEDDCKYLAKWIVDNGTITVQIRAKQSINRWTGIGFSPEGSMSGTDLIAVSVLDDGTSTITDQFVPDYNKPTLDSDQGIFDLVTKYENGFVYAKFSRELQTNDNSNDVNLESEHCNFFVYPVSGGDIVDKAEIQIHDEIPIVSEKKICLKACGIRSVKKEPVTAIPITPEFEITTIRSVDEVTAPSEEGSKTTISEVTVPSEEESKVTISEVSGEIEKVETTQGVVETSTAKTEGEHEPTTIAGTTEEEISFENINMNLPEKTPNVTEQSTTSKAPVEEPEMEHTTEKIEPTTEVKVTEEKVTDEASATTVESKGTEENVPSKTTESVPEPEFTTTEKAIPTTTESTKEIAGEDNTVTSTEGIFTTEKTTIQPKEGVESVTKPGNELDDEDDQISKNIINSIQNAGIINSSDEPTDGITLILRILNRKWDDSLLDKNSEAYKNLTKEVKETVQIIIKDKYPTLAYDRVLKYNKGSVLAYVHLEEQTLTDKEKSDLSDEQKTVPTIHDLSDHIRQVATLGTIGKLNVDPDTVRAYNSEGNSIDQVLLRNWIIVGLIIFGLLLLCCLASCLFFCCSKRSKKREKKDIIPHYGYGEYDNKGYKASLNNVSASYTVNPIYSTTPGSVNGTMKVHKTNGVSSPSTQISTQQMTIYTGGENQPNDDMTNVPEGLGETTYTEWQRDVASKDTPSHVQESTIYQPAVSSTLTRQTSPYITYPSEPTYYSMTNDPRYGHPHQNSPMTPSGYYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIP3</accession>
    <name>A0A0N5CIP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caprin-1_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIP3"/>
    <dbReference type="WBParaSite" id="SPAL_0001769800.1">
        <property type="protein sequence ID" value="SPAL_0001769800.1"/>
        <property type="gene ID" value="SPAL_0001769800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001769800.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24818" checksum="DE53CCD6356382DB" modified="2015-12-09" version="1">MTIPDMYTSLLLKVEKLEKELSEKKEGVQQLWITEQIEENKIREITNKMTMFEISEKFDDFRDVLAKTPQKSVNEEGKEDGLKKYLLELFTSKKNDEMKLVEVFSDQYNPRSVESAWTEASIKIQELTEVLKDKDKVILASMLIYLENVCTDIFGEQSKVKFREKLVKGDFKTIKQAEDFLKAAMIVQLDKENKAICEVNRLKEFDNSTHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W1</accession>
    <name>A0A0N5B2W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2W1"/>
    <dbReference type="WBParaSite" id="SPAL_0000041300.1">
        <property type="protein sequence ID" value="SPAL_0000041300.1"/>
        <property type="gene ID" value="SPAL_0000041300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000041300.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32630" checksum="DA6428BF0D5A3103" modified="2015-12-09" version="1">MSLRIKFLIQLKFSIFVNILIIILSTSIFFHMFQIHEVAVSYYKFVELEEIDIYKLIHENYVITGSIFMFLYITGMILQLVIIVHLIYFYFTNSPETVMKNMVFHTFMSTVVVFIFTVWSFFAYFMARLDKQNGYDLEENIWSSEESRLMLNTFYIPGVMLFVQMVIRETAYSPLFKEYSKLISLQNEERKLKNIDFIKVTQMKNELFNDIFREKIQKNEDVEEDKIDDSVLEGVKDLIGDYKILTNIKKELQSAKTIENSSKQESMSESSDQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3L6</accession>
    <name>A0A0N5B3L6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3L6"/>
    <dbReference type="STRING" id="174720.A0A0N5B3L6"/>
    <dbReference type="WBParaSite" id="SPAL_0000067000.1">
        <property type="protein sequence ID" value="SPAL_0000067000.1"/>
        <property type="gene ID" value="SPAL_0000067000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000067000.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36771" checksum="A4AE3442E6363EB7" modified="2015-12-09" version="1">MHYLKKWIKVSGYWTRLSIISQKPLLFEGDKFNFPNDTNIIFMIPGNPGNDGYYNAFGRRLLDNLIIKKPNDNYVFLTISHVNHVKMEEDNEHKGNVYKLDFQVDHKYNFVDKFLGKKNEIIMMGHSIGSFMMLKIYPRLVESGYKNIGLVFGLFPTIERMSASPNGQRLYSTLKFLDNYPNFTKCLTLWFDILPICVKKFLINCNFGFNSSIPSCIIESTVELFNTTVLRNIIHMSRDELDNVIEYDFDLRSYANNVYLYYGLKDGWVPLSYGDDMRNRKELNDGHVIFDTTNSEHAFVIKESEIIADKLTNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3W0</accession>
    <name>A0A0N5B3W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B3W0"/>
    <dbReference type="WBParaSite" id="SPAL_0000076000.1">
        <property type="protein sequence ID" value="SPAL_0000076000.1"/>
        <property type="gene ID" value="SPAL_0000076000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="61"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000076000.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26033" checksum="2D0ECDE0A2FD206D" modified="2015-12-09" version="1">XEKECIIELINDGEVFLAARGGAGGHGNRFYVSNEVRKPIKAEVGGKGEEITYDLEMGTMAFGGFVGFPNVGKSTLLRAISRAKPKVASYPFTTLKPHIGIVEYDDFVQIPIADIPGLIEGAHLDFGLGSSFLQHIKRCKCLIYVIDVSLGDYESQFDILKNELDMYKKGLSDRPTIIVLSKIDLVKELSIGNIQNKLNDTKVFPVSSRNMLGLEELLTHVRELYDYYNRDTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3X3</accession>
    <name>A0A0N5B3X3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3X3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3X3"/>
    <dbReference type="WBParaSite" id="SPAL_0000077300.1">
        <property type="protein sequence ID" value="SPAL_0000077300.1"/>
        <property type="gene ID" value="SPAL_0000077300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="348"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000077300.1"/>
        </source>
    </evidence>
    <sequence length="971" mass="112839" checksum="8B706326A0A11844" modified="2015-12-09" version="1">MSSLEGKPRQRILVALLETKFAELEHTEEQLDQWTQENLYLSESGDNRRTVKLEEFLSKEIEKRKIDDLSSSFELSFRHTEEESDKVIKTEIVDKEEEDMSKAWTEIDKFEASSGKSIKPMLERLKIAFEVDGTNVDRMKINLLKLKVCDDTLKFIDNLEEDKKNTFDNLAAELLNKYEGKVQLTTAMLMLRHFRIKNNPTTFRKECEEFGKLLDQCYNLKESEKIARLMSIVESDCVFNKLVQDFDKYSSYSEAVLQCECILKADANRKNSRSERKTFAGVCHHCQIKGHKSDECKFKKKGLPVGNYNKKKEKEVKKEDINNVVKSNERKQTDNLLLVDVKLNDKKIKALLDTGATKSIICNKVARDLNLKIDKNRSLNIATLGEKNLKMWKSQKSVNIKFKGYSFTKYILISDNEFSLEREYQLIIGNDILKDIPHFNELKKLSWDEANVLVVKNELDQKDELIENLKRKFEDVFSKSDYDVGNAELYMAPVELNGQNFEKPLYYPIQEALKDQSNQLIDELTSSGILIIPDENTDVEFISPTIVLSKGERKVRLVCDLRKLNKCVKRRHFPMPLLKHLLGRCSGMRWFTKLDQNSAFWQIGIRKCDQKYFGIYTSRGIRIMTRMPQGYVNSSAEYQAKISNLLKSIEGVINFIDDILIYWKNSRSVGMKICFQKCNFAGSACNFLGFEIDQYITKPCLSSKQKFLCRKKPETKKQLKSALASANYFRNHIYMFANITAPLESMLNSSPKRLQWEEETNSCWEKLREVVYGENNVFHVNFEKPFQLYCDASDYAIGSILCQDNKPINYFSRKLQKTARQSATFRELVSIVKSVLNFGPWLFGQHTTIFTDHSPLLSIFENTTNSQYIRLLSQIDSYSYDLKYINGPINPADFMSRLEENDKDKETFKAKLTKLEDFETPVLEGLQHDEIYESDDPWIENLDTDENDDKIIINVINKSAQIPCNNEKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4F3</accession>
    <name>A0A0N5B4F3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4F3"/>
    <dbReference type="STRING" id="174720.A0A0N5B4F3"/>
    <dbReference type="WBParaSite" id="SPAL_0000095500.1">
        <property type="protein sequence ID" value="SPAL_0000095500.1"/>
        <property type="gene ID" value="SPAL_0000095500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000008">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000007">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="84"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000095500.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39470" checksum="DA36F6F473D80A8B" modified="2015-12-09" version="1">MVWGNNVKYSYQPINTNLPLYNLPDKNKQFPFKSVIIFKGGISLKNNKLLTTEKKEKIWITLLEDWDDYNINNYDFIKTLCRRGIPKTIRGKVWLHLIKVSDKINLHSFENMAGNSKCVSEISKDLNRQYPNHEMFSDSSPYGRQGQKNLFNILKGYTILFPDRGYCQAQAPIAALLLIQMPPEDAFKLFIGICDGIAKDYYSDNLERLQKEGKILKSLLKIHLPKIYTLFEKHEVEPELYMVEWFLCLYSRTFPINVVLRLWDVLFCEGHKIIFKTALVLIKHIFMKKISNPDTVTILQRFKKIPEYLLDGDYLISEISKISIEHYELIQVHYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B540</accession>
    <name>A0A0N5B540_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B540"/>
    <dbReference type="STRING" id="174720.A0A0N5B540"/>
    <dbReference type="WBParaSite" id="SPAL_0000118700.1">
        <property type="protein sequence ID" value="SPAL_0000118700.1"/>
        <property type="gene ID" value="SPAL_0000118700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053123">
        <property type="entry name" value="CPG4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37442:SF2">
        <property type="entry name" value="CHONDROITIN PROTEOGLYCAN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37442">
        <property type="entry name" value="F18A1.7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893739" evidence="1">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000118700.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27188" checksum="A4DFD9D6EC6E7199" modified="2015-12-09" version="1">MIFHYFAVFLVGILAVPSNAALSVTVEELINAIGAPKCMQKCVNSFVLNLYDSMTNSSVQSATRVMCNEYYNFIECAKRDRLVCPYEVVYNYTFEGLNSFCSEKETPHSQCLDSKLSLVAKTCDNKCHLTRQIDDIFQRRTIKIMAKHSGNPQVFVENLTEFCQSLSCFIPCFKRNLEHECDKDGHRFLVHAVKPFYSLVRAMKKHPKIKPLIEKKVPKTCHFLFNKAVLDYYTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B547</accession>
    <name>A0A0N5B547_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B547"/>
    <dbReference type="STRING" id="174720.A0A0N5B547"/>
    <dbReference type="WBParaSite" id="SPAL_0000119400.1">
        <property type="protein sequence ID" value="SPAL_0000119400.1"/>
        <property type="gene ID" value="SPAL_0000119400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000011">
        <property type="entry name" value="3-ketoacyl-CoA thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF153">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="309"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000119400.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="48476" checksum="4ED25CB8811E8C4A" modified="2015-12-09" version="1">MLRSRSLTATIVRNFASKKDLSKKGLPNVVFVDGVRTPFAVSGTLFKDMMSVDLQRHALKSIVSKTGVDFADIGHISCGTVIQEPKTSNVAREAALTAGFPSSIPCHTVTLACISSNVAMTDIATKIQTGYCQAGLAGGVEILSDVPIRYNRKTRGAMLSMGKAKSLQQKLKLGGTIVSNLLKPELPAVAEFTTGETMGTSGDRLASAFNVSRDEQDDFALRSHTLADKAFKEGKLTDIVPMFVGGKKPATIDYDNGVRITPREKLAKLKPAFIKPHGTVTAGNASFLTDGASAALLTSEEFALKKGFKPKAYIRDYLYVSQDPKDQLLLSPAYVIPKLLDKNNLTIKDIDVWEIHEAFAGQVLANLNAMDSEFFCKTEMKRKEKFGRLPMEKMNLWGGSLSLGHPFGATGIRLMSHAAGRLREEGGQFAVIAACAAGGHGVGMLVEVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5L4</accession>
    <name>A0A0N5B5L4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RT_RNaseH_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5L4"/>
    <dbReference type="STRING" id="174720.A0A0N5B5L4"/>
    <dbReference type="WBParaSite" id="SPAL_0000135800.1">
        <property type="protein sequence ID" value="SPAL_0000135800.1"/>
        <property type="gene ID" value="SPAL_0000135800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="468"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000135800.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70894" checksum="CE975785CF81E55D" modified="2015-12-09" version="1">MEDTMMLEHLNSEAVRINNERKSQSRQRTGEHGSNTGAKVKAAGGKIVYFICGLENHKLFACPTKKSSKPSEKDASKVRRIVDRSTGLIIPTSINFSEGEVKVLDEYIDTGADMTLVSEELASRLITHKKKVKLQFGGEDRWEGNVFIVPAAVVPTAIMISTNYTHILLGSDSIKKVSARIACQETAPSITIRRQAKVSVPESQIKVFDKEISLLAKEYPDLITDKKRELKILSYIVESLEFITKEIPEIVMYAISSAKEEIISKECQSLINLKVLQPCLTPRFIRNLVVAYKDDKLRVCADLRRLNTCVKKIATYIPTPDVIISKLCGANFFLQVDLQAGYHHVQLDVSIQDYFAVFTPMGLFKFCSLPFDLTNAGVSVTDGVDLAIYIDDIIACSKTMDGLVDLTHRMFKALQGCKLKRSKIQFRQLRRWCGMVTYYARHVTDLQRIMAPLARLLKKGVEYESNQGCRESFNLINEILSKQPCLMIADVKKEFFLEVDSSLDSCGAVLLQKDDSSKLVSVAYYSKRFQLLKKPSSVTMLELREIVAAIRNFKGLTSDMTIITDHKPLLGMLCHGKAEELFQYLSVVEEAGCRIKYQQGSKMYTSDVLSRMHIRRHLAVEGGRAYSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B645</accession>
    <name>A0A0N5B645_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B645"/>
    <dbReference type="STRING" id="174720.A0A0N5B645"/>
    <dbReference type="WBParaSite" id="SPAL_0000153400.1">
        <property type="protein sequence ID" value="SPAL_0000153400.1"/>
        <property type="gene ID" value="SPAL_0000153400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000153400.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18603" checksum="F4486AD3D0D05704" modified="2015-12-09" version="1">MNSTTPSVPQELLENLESLSVGKVCLIGKELSKDLFRKIPIFLRCFKDNLDKKTYLPPEFEMLLNSCNLILQKIVECRIIIDKKLNRSNEICPDYFIKQFSKGNCSPIKKSNVLIGKEQEFDKNRIKLIKLSNALKWIDWQDTVIDPRNLKKPQAPLAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B656</accession>
    <name>A0A0N5B656_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="2">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B656"/>
    <dbReference type="STRING" id="174720.A0A0N5B656"/>
    <dbReference type="WBParaSite" id="SPAL_0000154500.1">
        <property type="protein sequence ID" value="SPAL_0000154500.1"/>
        <property type="gene ID" value="SPAL_0000154500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="10">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="9">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="516"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000154500.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="90013" checksum="C1C09E9F1EC86862" modified="2015-12-09" version="1">MASVPTEKSAEEKKNDKLATAILQTKAKPNRLMVDQSNDDDNSTIFLNQTKVDELGLFRGDTVLIKGKKRRETVAIVVVDDECPVDKIKMNRVVRNNLRIRLGDFVLINPLPNISYGERVHILPIDDTVEGLTGNLFEVFLKPYFTENYRPVCIGDIFSVKAAMRTVEFKVVNAQPSPYCIVAPDTMIHCEGDPIKRADEEENLNEIGYDDIGGVRKQLAQIKEMVELPLRHPQLFKSIGIKPPRGILLYGPPGTGKTMIARAVANETGAFFFLINGPEIMSKMSGESESNLRKAFAECEKNSPSILFIDEVDAIAPNREKTHGEVERRIVSQMLTLMDGIKQRNNVVVIAATNRPNSIDPALRRFGRFDREIDIGIPDAIGRLEILRIHTKNMKLADDVNLETIANECHGYVGADLASLCSEAAIQQIREKMELIDLEDDTIDAEVLNSLAVTMDNFRFALNKNSPSALRETVVETPNVTWEDIGGLENVKKELQELVQYPVEHPEKYLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFDELDSIAISRGGRSGDAGGAADRVINQVLTEMDGIGAKKNVFIIGATNRPDIIDSAILRPGRLDQLIYIPLPDEASRLQIFKANLKKSPIAKDVDLKYLAQNTIGFSGADITEICQRACKLAIRESIEKEIRMEKERAERQSRGEEVMEDEVDPVPELTRQHFVEAMKYARRSVSDNDIVKYESFSETLQQQRGFGNNFSFPQDGSHNVGGHSAPQPSNDDDDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B873</accession>
    <name>A0A0N5B873_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B873"/>
    <dbReference type="WBParaSite" id="SPAL_0000224600.1">
        <property type="protein sequence ID" value="SPAL_0000224600.1"/>
        <property type="gene ID" value="SPAL_0000224600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="2">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000224600.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31091" checksum="28080D255AB674AF" modified="2015-12-09" version="1">MEMTTVPLIPEPDYNSINKYDRGLHHHYIPSIPKKEITSLPKNLLERYEKISQLQYNKPIDKERALRIARTQGVPVLPHTDNNETSNSDKIIITNRAMLVHVKNHKNFDDEGHNFESCKNCIICRCNTNNNLPSPSQNKNSFNKNQEEYIPTNCDLLEDVPQEPGYLSPILLDLSNDTQKKLIFPRSLHKRKDKQTDNLNNDHILNNDIEEQITRKIIVTRSFNASRLDELSVNYGEVVKLITIKDSWCLIENSDNLKGWVPYPESFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8R5</accession>
    <name>A0A0N5B8R5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8R5"/>
    <dbReference type="WBParaSite" id="SPAL_0000243800.1">
        <property type="protein sequence ID" value="SPAL_0000243800.1"/>
        <property type="gene ID" value="SPAL_0000243800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000243800.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12687" checksum="DFE260389DB293D1" modified="2015-12-09" version="1">MFYCFLKKFFLLNITIIYLLFINTTFGATIEGNISKRSAKMAFSQSSNTEDNGFQEFFENLNPIYPIIIGGLILAGCIFELIHGTRATPPRTNWAHVASKQQPYSVNTIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAS2</accession>
    <name>A0A0N5BAS2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aurora kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAS2"/>
    <dbReference type="STRING" id="174720.A0A0N5BAS2"/>
    <dbReference type="WBParaSite" id="SPAL_0000313600.1">
        <property type="protein sequence ID" value="SPAL_0000313600.1"/>
        <property type="gene ID" value="SPAL_0000313600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000313600.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33078" checksum="FCEE9208BC762B8A" modified="2015-12-09" version="1">MTSKPDYYGVPEAPRRTSSELKWLSMQDFEFGTFLGKGAFGSVCLVRHKRTHYPYAIKILFKSHIVDSEAEKHIANEIELQGRLDHPHIAKMKSWWQTSDKLFFLFEYCHWKTLFDVIREERRLREKYALKLFSQVVSAVDFCHKHNIIHRDIKPENILLWRRDHAKLSDFGWSACSTPGVKNITICGTLEYMAPELVTEMGHDYRVDNWALGILLYEMVHGSSPFASDDDKECKKNIIRGTLRFYTEVSHFVKDIVIGLTHRIPSKRMETKDIIRILEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCW2</accession>
    <name>A0A0N5BCW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitinyl hydrolase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCW2"/>
    <dbReference type="WBParaSite" id="SPAL_0000385700.1">
        <property type="protein sequence ID" value="SPAL_0000385700.1"/>
        <property type="gene ID" value="SPAL_0000385700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000385700.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24539" checksum="A58D4FC2522E9DD4" modified="2015-12-09" version="1">MASKIKESGSEEYINDRNILNPFFYRLALCFYQQSYIKSVLEQYRGNEEIEKMRREVYEFYMQKLAKLKRYSQIELEKHDPDVCGLSLVNFEAMTKILNSRHPRDVVWEDHTLLDGYQDMLYMISNLTFKTLLDEMIRDVDSTVETHNTSFPAWKIFAVNDGNESHAEDEVYLEVALKVKQRKLGKLGENIENDGVCRNDDINKQNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDI4</accession>
    <name>A0A0N5BDI4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000406900.1">
        <property type="protein sequence ID" value="SPAL_0000406900.1"/>
        <property type="gene ID" value="SPAL_0000406900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894331" evidence="2">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000406900.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9894" checksum="A2CA1E0EC466B155" modified="2015-12-09" version="1">MVLTISQTTFLIILLFIITNANPCFVWDPLSCQWKFVCSPIISTTTTKRILKTTTRVLTTTTKKSQKTRTTTSVKPSSTIETSSLNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEB3</accession>
    <name>A0A0N5BEB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEB3"/>
    <dbReference type="STRING" id="174720.A0A0N5BEB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000433600.1">
        <property type="protein sequence ID" value="SPAL_0000433600.1"/>
        <property type="gene ID" value="SPAL_0000433600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF170">
        <property type="entry name" value="MECHANOSENSORY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="277"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000433600.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49539" checksum="8FEB4350D000D899" modified="2015-12-09" version="1">MADIFDEYFIDTKPLEAISQVVDSIGNDDIKIYNHTHIKNEVHDVNNSKKNIDHDDSKQCCSGCNRKILDKNFLAISSTEIPLNNKVNVTYFHESCLRCWTCCIKLDPNYPCFCKNNKVYCKNHYFKEFSPYKCNGCGDGLSKTDVVFKVQYSTDSYYFESKKNYCKGTLKKEEIETNVVLFYHPKCHKCFYCSKSLAEGDKFGFNEEVVGESITNRPKKVSSKESSGKCSGKSNPSSKKISSHSLISALPPILQYPFEMYTYGEMCSDDQNNLLKRRGPRTTIKQSQLDVLNKIFLTTPKPSKHARAKLSLETGLSMRVIQVWFQNRRSKERRLKHLCNFLRHYDRNAPRPSSQINITPFIEGADDSEIIVTDDSFNNGYMDLNSLSPSSNTSSNMLNIDVNSFCEEIDYDFDDCRNTEFISEEEVYDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEX4</accession>
    <name>A0A0N5BEX4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEX4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEX4"/>
    <dbReference type="WBParaSite" id="SPAL_0000454400.1">
        <property type="protein sequence ID" value="SPAL_0000454400.1"/>
        <property type="gene ID" value="SPAL_0000454400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="126"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000454400.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="33150" checksum="0279905863FC0359" modified="2015-12-09" version="1">MKYFSKCKKWGNPIKKAPKEQKEKNFFIDETVGRKVVDGTTYYRIKWLGYPDDAQCTWEPSENSHREYIKYFEENYTPVGESTDGSTFFIKKANKPSGGRKRKAFSKKAGESRNSSESSENEDEENIIERIVDSREINGEKIYKIRWKNRPSDDDTWQTIRTLGDPSIVQEYEKLKLVKLDELKTTGNSDEPSEEEERGFLRRLMKEVRKGVRYRDEEVVGVIDKHFNSDNEKFYLFLLKNKRIVYVHPEDVPENIKEECMYADMKRLLINENAIHRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF11</accession>
    <name>A0A0N5BF11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF11"/>
    <dbReference type="WBParaSite" id="SPAL_0000458100.1">
        <property type="protein sequence ID" value="SPAL_0000458100.1"/>
        <property type="gene ID" value="SPAL_0000458100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014:SF1">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000458100.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24920" checksum="A390BD008FA05627" modified="2015-12-09" version="1">MHNLIQFLSIANIGSNLSTSTCPPYTYTNVVNCYRSYFEYFNLTIGPNLEFPDYQTYKSNRAKLESTSEVVDFINDCYIRNRLASCLGIDTYCINPDDLSKIGKFKYNDNFQYSSDYSMTSYECTTEYNYIINNYNCLINVNYLSQDEISNCVENYFKNIPSEGQYPAINDYISCFDTVYSTHCGEKAGDLFCNVLTIGDNIQFPECNGKLMTCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF27</accession>
    <name>A0A0N5BF27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF27"/>
    <dbReference type="STRING" id="174720.A0A0N5BF27"/>
    <dbReference type="WBParaSite" id="SPAL_0000459600.1">
        <property type="protein sequence ID" value="SPAL_0000459600.1"/>
        <property type="gene ID" value="SPAL_0000459600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000459600.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9235" checksum="A33AC5D4E31F6691" modified="2015-12-09" version="1">MDTLYELKEQQLPNKIFDETSYLSSISTSQVSQNIENNISKKFLNSRTRIKKLKERIIYIFDYREDIRNPECKSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFF9</accession>
    <name>A0A0N5BFF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SANTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFF9"/>
    <dbReference type="WBParaSite" id="SPAL_0000472500.1">
        <property type="protein sequence ID" value="SPAL_0000472500.1"/>
        <property type="gene ID" value="SPAL_0000472500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053090">
        <property type="entry name" value="Centromere_KNL-2_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015216">
        <property type="entry name" value="SANTA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35311">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN KNL-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35311:SF1">
        <property type="entry name" value="PROTEIN EMBRYO DEFECTIVE 1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09133">
        <property type="entry name" value="SANTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANTA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SANTA" evidence="2">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000472500.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="69098" checksum="0D072F68E32C79C6" modified="2015-12-09" version="1">MDVSDDFVYLSNWVIKFLEGEHNDFDIILEGIVGRNSLSLTENEYYRTDSVIGVLKYNTILCDGNVKVTLESQINEQDMLEMGFTEECISCFKYGFPTNWIELLEYVYDKIMEQSDLSLPEELFEVALRNMDEYKNINYDNAVSLINWDISLSLHGDDDFNIILNGTISDSSDFDNSLKKITEQILDREKINLVSCTNKQLYKLDSMINFSQMREHGYTIEFIECFKYGFPNNWILLFDELYNQYRNSVNNFIFSRNLINEAIIEMEDFEQANSISQPSQEKQNDLVENEEIKHLHIVESKDKSETILLSPQTFISSHYSDKNESISFPNAHLSKDEQISTHSVLQTPGAPLIMSTPVINKFQQVLGDVPYSNFSPILMPSSVEVLKNKNELELVMTPTLSINESNGDGKHQTTDFFAISNDCGSLSEVRKRKVDKQVKRKILSSPENTPVKKNEVKKKSRKKILKKKHSATKKVSSKLTNCENLAIDINNDQSIQDLFDATLGLGDLENTKRGKFDFTDDSIVGRQISEDTFKEVGNENKNLVYYLPANNHIYKKNPKPKKVEKKPTEDIPFDFEKLVYEEIEKNKASESYTLEERLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFQ7</accession>
    <name>A0A0N5BFQ7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFQ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BFQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0000482200.1">
        <property type="protein sequence ID" value="SPAL_0000482200.1"/>
        <property type="gene ID" value="SPAL_0000482200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000001">
        <property type="entry name" value="cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 14" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000482200.1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8609" checksum="EB825E79FBD4D6DD" modified="2015-12-09" version="1">MNKVYLDQLRIMSEKKECPMVVDPKTGEKKPLKPCCACPETKKLRDECIIRNGEENCGPLIEAHKKCMRDLGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFR3</accession>
    <name>A0A0N5BFR3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OCIA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFR3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFR3"/>
    <dbReference type="WBParaSite" id="SPAL_0000482800.1">
        <property type="protein sequence ID" value="SPAL_0000482800.1"/>
        <property type="gene ID" value="SPAL_0000482800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000482800.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28925" checksum="317C10D21260310C" modified="2015-12-09" version="1">MDENTMFNSHRLQSTTKDVNGAQLQYLFERLSTDDRQMLMTEIAKIQKDALLTRTLPITAFGVGCMYYARTKLKIPALLKRKPIQLYVGIGLFSFLSSGFITRPLCRKKLQPIYSNLVEKYKVNEQSEQNISKHGGYEELRRRNRLGNSNLYESPPLASDNYNEMGNVKPYASDSKFNPGLEKEDNVKEAPRMNTDPNRQKNPYAGYNYDSYGYMPGTPIPKFSNENSRNNDGSGKPSYDSPTKNRYGDTDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG59</accession>
    <name>A0A0N5BG59_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CdiI_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG59"/>
    <dbReference type="WBParaSite" id="SPAL_0000496700.1">
        <property type="protein sequence ID" value="SPAL_0000496700.1"/>
        <property type="gene ID" value="SPAL_0000496700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000496700.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13238" checksum="48FBA952936BDBC9" modified="2015-12-09" version="1">MVYLNNIEQKCDIRIAQEAQNLMIHGFPGDDLYALIEEMRELHKEIEENGHRVDEGRMSKIKSRIESTFKTYFYDSAWEEWEKKNCPSIDHYHGVKYRVKRQLRAIKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG65</accession>
    <name>A0A0N5BG65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG65"/>
    <dbReference type="STRING" id="174720.A0A0N5BG65"/>
    <dbReference type="WBParaSite" id="SPAL_0000497300.1">
        <property type="protein sequence ID" value="SPAL_0000497300.1"/>
        <property type="gene ID" value="SPAL_0000497300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000497300.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35662" checksum="694C330E0065C19B" modified="2015-12-09" version="1">MVLMEPDIFRFPEYNFTLKKETILINRDNNDGLGFTIIGGIDYPYLPGHNGIFVVSVRPNTVVGRDGRLKAGDLIHKVNGKSLHNLKHSNAVKILKNLKPGPVVFEVTFNAEKCILLQLKQTSVPGKGVLRNRTSICSEILRRDTLISNTNKMAAVVGSKNTENLFYYTPKYKEEIENYEDDTGISDSETDKSSAKNNYTPYSRHRFISSSSSIYGKNNYNRASAYYEYMNFDDDDMLERASTVSYTPSVVGNFQEDDCIITSTETPRRRRTCSLNDIENVIDDDIIPYSEYVAAIVGVGVVVTCGVLAYRYFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGM7</accession>
    <name>A0A0N5BGM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BGM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000512700.1">
        <property type="protein sequence ID" value="SPAL_0000512700.1"/>
        <property type="gene ID" value="SPAL_0000512700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000512700.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26659" checksum="B744FFF0D7E67BF0" modified="2015-12-09" version="1">XGLKQGCPASSMLFNAILEFIYRNALLDDSLNLLPNFGIAVNGLRVVGISYADDTTLIADSSDSFKEMLSALKYHSKRVGLDINLDKSNYMAFKVEMEDSFEIPSCTSFNYLGRELSFIECRPFIRKIKVRGYKALSVIRPALRTVSLKAKRFLFQSTIRSCYTYACQTWTLAKNSLYDIACLDRKFILSCKLIDAEEIRSKETIPSNKRIPIGLIYTYANMEPLEQYVFQTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH17</accession>
    <name>A0A0N5BH17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH17"/>
    <dbReference type="STRING" id="174720.A0A0N5BH17"/>
    <dbReference type="WBParaSite" id="SPAL_0000526400.1">
        <property type="protein sequence ID" value="SPAL_0000526400.1"/>
        <property type="gene ID" value="SPAL_0000526400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="3">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000526400.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13122" checksum="DF3651950F8FD08F" modified="2015-12-09" version="1">MLSKRSIRAIILYEFKRGTNAAKITQQINESFGEDLVSVSTVQRWFRKFKEGSEDLENEERGRPETVIDNDELREAVEANPRATVRSLAEDLNVSTATISRHLKEIEKTKKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHC4</accession>
    <name>A0A0N5BHC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHC4"/>
    <dbReference type="WBParaSite" id="SPAL_0000536700.1">
        <property type="protein sequence ID" value="SPAL_0000536700.1"/>
        <property type="gene ID" value="SPAL_0000536700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000536700.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50042" checksum="7A2D4AFE90BC9E29" modified="2015-12-09" version="1">MVTETKDRDSRDKSIDLLDDTCKTNDTTDDLNKTEDSMEGNLTEDGGSVTQSDDGELNRTTDSLDGNLTEDDCPPLPSSKHPAVLLERQNLPNLPKTSSFGDLTQDTISVNDSRNTFNSGVMSESKQGNLSAINRTTSTVSDGCGTVTRAKSKSRLNNALFMVSNITQSTMDNSTKLFGLTESTINLKSGMSNIDDGGRRIGRIGDKFLPPITEELVAKINKIVSNGNNEETIRRLVELTEEVSRENFNRLAREVDVEYSILERTLENYCEAFQQLKDQCLQKNSSATSTSKGDRIEAHMKSLVDSIEHTKSQLELGIKSYNDQARMLETSSANNVTQIKHLWEQYDGIKEMERQFVQYLDSYRKLRIHYKRLLLSTEARKEKAREEQERNLTILKLNVRKHQKDIEEENKVLQSKKDNLKDLENILNLYMEKIEGDGDQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHJ1</accession>
    <name>A0A0N5BHJ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHJ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHJ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000543100.1">
        <property type="protein sequence ID" value="SPAL_0000543100.1"/>
        <property type="gene ID" value="SPAL_0000543100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000543100.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="85233" checksum="F6AE9A5CA6CB9661" modified="2015-12-09" version="1">MKRISNIVDTPIYQLPGSDRYQHTEDEAVSSIPTKKTKFDRELSKENDENANRHEGSSTVLNFVLNVDDGQDVAPKRSKTTRRRGFPIKVTRIRARRDTMSIEELQDCLDRKLEEKINRSGCVKLIDRTHVQCLGCPAVISLNRKFEVCHIIRHFSSWHKTNHFCTRTWPGLEGRLYTKSNTYLKLLHGCPKDKNFFTGKEISFVPKDEDVVKKVTSRDKCKKPLYGPEKSSFNVRCNLCGFLMEHRDVSTHFLTCHSENINAPRCNLCTQEVLINAELKFLYEKDYQISIVDEESTRSITLNRSFGGVDDLYKVFSASDFGESTYSKDNSLDEAINMEDPQEEDTLKVEGSNNSRDLGKGAKPKRVFVHPRYRQAVPENSRFVEELAINQWRCKLCDAIIVGAVISSAATKHFKKYHYEDSTYFDEGTNKERYNPKSIFYQFSMELCDARLIKCSRGSMRMIDERTICCKECNGDCMNLHKDFNICRGIKHLKSKHPELMPEHNESVDGEIINSGDLCGIEDSRGLLLDEDLPHVYEVKEESFSDHNDTISHSGAQDNLVPDVFKDYVPASSLGGESALLAPTIKEECLFNPQENDHDLTGLPYKPNNSLSRIETAHRNIFEDASYDDVISCNVDYDDYVSNNFPDYSSTSPSYLYGLNSMEHSDNYPSSSLLPSQGTLGIQLYDGSTDFFAKVVDYQNYPIPMDAVDSIIMMHDIDGRECYILMTEADELNFETAFKIFRKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BID7</accession>
    <name>A0A0N5BID7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BID7"/>
    <dbReference type="STRING" id="174720.A0A0N5BID7"/>
    <dbReference type="WBParaSite" id="SPAL_0000572100.1">
        <property type="protein sequence ID" value="SPAL_0000572100.1"/>
        <property type="gene ID" value="SPAL_0000572100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="336"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000572100.1"/>
        </source>
    </evidence>
    <sequence length="770" mass="86706" checksum="9045BCDBEA51A907" modified="2015-12-09" version="1">MLRSIKRLHNLNGILSIISKNNSFQKNLEIFQIKYDSLYKIASSPIGRGNKLFFLFLNYLVQARNKRLTSKNYEKRRERTQQIKENLENHKAKSSNESSSSNGDSKENEKKDPDEDDKKKPPNDIAAVFKQLFGIGLFGWGLYVIFNRDNPSNSFSEDNTISQNSFISKILPSGHVYQIIVTPEDTAAYAFVHSGTKLQDGTFLQPKYKIILSNLNKFENDIRRTEIQHGIDPSNWVEIKFKRFNNETFLFKIALFGSILFLMYLFFKKAMKMQPMSPFSTMSKAKIKIYDPNTKGANLDIKFKDVAGIHEAKVEIMEFLDYLKNPSKYTRLGAKLPKGAIMTGPPGCGKTLLAKALAAESNVPFLNINGTEFVEMIGGLGASRVRDLFKEAKQRAPCIIYIDEIDTIGKKRQEGNSSFGGGDSETEQTLNQLLVEMDGMSSGNGIVVFASTNRPDILDKALMRPGRFDRHISIDLPTSIERKELFELYLEKIKLDNVPSFYSGRLAQMTPGMSGADISNIVNEAAINAASNMKKVVTAKELNYALERILAGPEKKTKTLVKEERETVAYHEAGHALVGWLLEHTDALLKVTILPRTSAALGFAQYTPRDKKLFTKEELFDRMCMMLGGRAAENIFFNRITTGAQDDLDKVTKQAYAQVKIYGMSSKVGPLSFPPDQSLANPDFAKKMYGNELARIIDSEAKELVSKAYYTTEKLIKDNMDKLNILAKELLTKDSLSYEDVKRLIGPPPFGDKNVIEIVEQSLPDLEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIG7</accession>
    <name>A0A0N5BIG7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIG7"/>
    <dbReference type="STRING" id="174720.A0A0N5BIG7"/>
    <dbReference type="ESTHER" id="strea-a0a0n5big7">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000575100.1">
        <property type="protein sequence ID" value="SPAL_0000575100.1"/>
        <property type="gene ID" value="SPAL_0000575100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580:SF6">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580">
        <property type="entry name" value="PROTEIN CBG05369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733516" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="27"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000575100.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="71735" checksum="B90681580F37274A" modified="2015-12-09" version="1">MVLYGILVILNLLFICNSTEDQEFLIREISNGKLIGKKVYSTNGKIFGYAYTGIPYGSPPVGPLRFKAPLDPNNWDGIRNCTILPKGCFIFRTKSKNILYDTKEMSEDCLYLNVYTSKQCLINGKCPVVLYLYGGKFVTGSVKSFNETSLIENFANDERNIVFVNFNYRGGILGFLALNQKYKLSMNTNAAMYDVIAALKWIKKNVISFGGDKDDVTLMGHSSGGVIASYVYKSPRSKGLINKVIIMSATHRHVHFKDANEFYGRQTAIQAGCASYNTDWNSISQIESTLNCLRNLSLMELSKYSDEVEDSCWEYLGPSSDYESHSFMQYDWKKLSQSRNNIPILIGNAVYELQEGKHLLDSNNKVNIEKLRLYCNNFLSYDEFENPNKFLERCVEEYKNDSKRIIGIGDEKHIFLQNILISNEVTKSGGNVFLYQFSYKKTGEAIKPKNYPLTPHHSTELVYVIGLNKNKFTDKDYKIQEYHSRMYTNFIRNSNPSDNEIIFEKYDPEKNNYYNVDFNDNGDTISEMKDKYNEKALNFWLKSVGEYGHRMSEDGHIVIDSDPVYCPKKAPGSAGRTVKLFTNYFGLKLGNTQGTVVYQYEIETAKILNNGKKVIVNKKREAGAKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIK5</accession>
    <name>A0A0N5BIK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000578500.1">
        <property type="protein sequence ID" value="SPAL_0000578500.1"/>
        <property type="gene ID" value="SPAL_0000578500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000578500.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36810" checksum="7EC1836D35363A35" modified="2015-12-09" version="1">MAIISVIGIGYLKPHIYAFDDFLVAFSRPLSDPPSNDFLHSSLFGLSVFLLYSNITIPTGLIAARFSIVCTNSGLNKNFIFRILGLCITLTIIQAVGITFPFSEHISSDIKIDAIKKYNIESDILTESTAVLGRKIVVVWIIVNEDIPENILSDWIKKNNISLIGISESTEAIAFNLGSMLSYIVYALLISIFSVTYIIIILYVKKYRKYIASYSSIMSNNTLIINRQFMMILIFQSSVPVIVTGIPIIIFFIMIITENTKTLSTFGILLVNLLMLVPCINPILFLGLSSRNRKYLCFHFKKFTNCLLCKKENAGLVNTFKSQSKMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIP4</accession>
    <name>A0A0N5BIP4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIP4"/>
    <dbReference type="WBParaSite" id="SPAL_0000582400.1">
        <property type="protein sequence ID" value="SPAL_0000582400.1"/>
        <property type="gene ID" value="SPAL_0000582400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000582400.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19743" checksum="681BD6C704620104" modified="2015-12-09" version="1">MQMAGYTLRRRARKVSIDNSSYKRVAFKKFYTDCCEDDGGYVLKAKRPFKYGEKLMDLNGKYIVEPLEAVKILEKCQENPRLHRTKFFIKTNESFFCCDLERSRNDPSYYLLHRRTTGYNCKPTIYYTKEDTNKLNPKISIEATKLIKKNEPIVVYYGILWFLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ21</accession>
    <name>A0A0N5BJ21_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ21"/>
    <dbReference type="WBParaSite" id="SPAL_0000594700.1">
        <property type="protein sequence ID" value="SPAL_0000594700.1"/>
        <property type="gene ID" value="SPAL_0000594700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000594700.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="37521" checksum="BDF92019354E0D54" modified="2015-12-09" version="1">MFNSILYSNHFSNLKTSFVVLQNNIRFFKFSSKNYCGTIPEKESSLNSVEISVLDHDRNLRWEKGKYVVNWPSHRQYNAIGNGLHTKKYHSENHRYYLSALIYVMIRAIYNLKLNNIRIITDGRYLKHIIDKKLDFHEKNNFVQYRDGVKEKKRNGDLFKIICMLRKRIELSCVVENLVDEMGRNKPTMDVVRYYNNIELDEEETIKRYENLVEGKRNLWYYLDGGNKVSSRKSYPIFDEPHFKAELKNASKYASVYYVGGVLVDKNNQEYLPKFVFQSFKDRICITETVSQSQLNITLVKLMGIINCLEYVCLLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJV5</accession>
    <name>A0A0N5BJV5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJV5"/>
    <dbReference type="WBParaSite" id="SPAL_0000622200.1">
        <property type="protein sequence ID" value="SPAL_0000622200.1"/>
        <property type="gene ID" value="SPAL_0000622200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000622200.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17699" checksum="E6818D37A8980580" modified="2015-12-09" version="1">MLAINGIPTQCLINSGSAISMIHADYSKYYTAFDCEFNIKDVTSVEETIRFYSKLNGYYIEDLESTASAAVEIARKTIPVQSLHTKVQAKNLEIQSKATLLKSNEYVTSRITESHSDECLLNVFLWIKLLMINVVRMFPTLLLISLKLYRSVSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK65</accession>
    <name>A0A0N5BK65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TFIID_20kDa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK65"/>
    <dbReference type="WBParaSite" id="SPAL_0000633000.1">
        <property type="protein sequence ID" value="SPAL_0000633000.1"/>
        <property type="gene ID" value="SPAL_0000633000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000633000.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11417" checksum="96009A35B4735DA0" modified="2015-12-09" version="1">MENTNRNYEKEYTVGEDIITIENVKQYAAMFQPNLTITNDIATILIESLSEYLDNLISLSVKMTKHRKGLYVQKKDVVEALKKRSTLVVLDDINDDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK93</accession>
    <name>A0A0N5BK93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK93"/>
    <dbReference type="STRING" id="174720.A0A0N5BK93"/>
    <dbReference type="WBParaSite" id="SPAL_0000635600.1">
        <property type="protein sequence ID" value="SPAL_0000635600.1"/>
        <property type="gene ID" value="SPAL_0000635600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="279"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000635600.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="95530" checksum="0A11977739909960" modified="2015-12-09" version="1">MDDFDVNGILEEPVDFAGADNRDFEENQNLNLTHNIAPTNNYESVRKAQLYTLVDMSDDKALENWYLRFNFHDAEERIRKIEELQMEHVQYITERLKNIKNGESNSDGVLVGQKNASAKVFVNKGLLETPPLDSDWIGISVGDGSNRKYIKIKKKNDEYLKFLYKSDRKESENDPWNELFTKVFNEYQEEKSRVQNTDTNTERVNLNESERKLLIQKYECNEGYFTLISDCSANRITLNWLKLWDKYVFGKTDFVAPEKPSWNEKGIYDVDETDSNKPKKKMLGLFGPTGCCKTTLARNIAKLCGYNVIYIPISDTLTVEQVKNKIERGITNVSMNFYLKPRDGMETDDSITIKPNCVIIDDIDFASTDLLDYLMKLSKEKGNKSLKRPLILIGNNVYSSNLKELKSNIAVVKVSPIFSNILLKRLVEICTIEGFTIKKYQLNELIEECYYDIRRCLNNLQLMFAGKDLPDEYKAHNEISSDSSIVSIWDQIFIINRHWDSQGNMLPLSKRLDRIRNMIDRSEYADRLVFGLFQNIGVINNDTPSFNRTVSRIFEDVQLFYDISMREQLYSLLRYRSSMVAKFHLVCAFKKPLRSSRLKYDFTGPNDYRAKQEYVSILQHFRRIKSFFDWSNMMFFDDLLPYLIFILCPNVKLININYSSEDDRERLRQATGFMMQLNISIKENKNNQNVYKGLNDITNGNYFESTRFEPDITKVCVLFYDSVLKTRNSEFERKMLCSQISINKEIKTYKKIVGGDNSLSNKEIPKCMAQILSILKPNELEEKTLSKKRKVNDPKIFYVWDEDSTEIANTKTIRLCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKB5</accession>
    <name>A0A0N5BKB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CLASP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKB5"/>
    <dbReference type="STRING" id="174720.A0A0N5BKB5"/>
    <dbReference type="WBParaSite" id="SPAL_0000637400.1">
        <property type="protein sequence ID" value="SPAL_0000637400.1"/>
        <property type="gene ID" value="SPAL_0000637400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="4">
        <location>
            <begin position="99"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="5">
        <location>
            <begin position="828"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000637400.1"/>
        </source>
    </evidence>
    <sequence length="1003" mass="116971" checksum="E6205174AE97B96A" modified="2015-12-09" version="1">MTIENSINLNDLCKEIKSLVSLSHNDFKDYFATIENYCLSNVENLNNSLYKVLELYSLKNEKCCCFVIDFIAKASSLDCSIMVKSVPILLSAMKNGKLEVQRHAVLSCSNIYERVLRWVMENMGDVTVQKTWEMFCTLKERIFAAFPNLAQSVRMYILRLMEKIVTCQTTLEGEKNDEEDVGFSLNDIPRTHKFVSYRKMQQEGEDILRKMIALFSDKNLSLSLALVNITSLFNIGRKRTVLMSLIIKSVHSFINNGLPRYTEYSFKSLRKQIKKEFSRILGMDNMDSFKVEVVNNLRLMGFTTAEIEKIKIENSRAARAALKRKAAGPVHYDFDYGPKKNKTIYREVVATRQNVVIDSIKHERERIEEIEKFSNFAFLEIIKTELVKTCINVFLEFKDCHTILHNKLTEMNETELEKYCSDVGSRLAFEEAGCVREPISIIKRKDVFVLAEPKVYPCPTNYDIYFNPIRKLEGINNEEKETMFEYNFTRMLKNEKILKTVGGFNAFTNSIVGYITKFYNTKTVKCEQILINFIIENPEERMCIAIAWLDELFNIYDDYKSNCFTVNNEEGLMDEDEAFERYCNILDNLLEASFNKHNYNSPLYETIFSNVRRYSPNALLFLEKMILSAKHTESAFRYLENAFVSQSRNIECLFEFLWKFTVSDNNIISEHAMNLGKLLYEDMEFRENIKLIIEEKLEIVCLPNCPEYFKSTEFDENGLAIWNSQLIKRALNLFTEYLLLDSRLYEKLLEVFIKSDNRVKKEIIRAVEPSVMKHGIDNEDILNLIRTTPKSGEILSLTIVSHLTKDRSPTKQLVECVKEQHRRINCHVKCLIPILVGFSKEEFLEILPKYFDKINSVNVFQPLFKKVLQEKAIDSNESLISPSELLLKIIEIGVDDNEELVSQAIDILLENLFIYSGDIMKVLEESRLKEYFTKTFFYTVEKLYVLAKSSHDFIFELITKISQAYSITDNCELWNYYKTICVEVSKDPRMFSFSNGCEYNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKR1</accession>
    <name>A0A0N5BKR1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNRIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKR1"/>
    <dbReference type="STRING" id="174720.A0A0N5BKR1"/>
    <dbReference type="WBParaSite" id="SPAL_0000651700.1">
        <property type="protein sequence ID" value="SPAL_0000651700.1"/>
        <property type="gene ID" value="SPAL_0000651700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031718">
        <property type="term" value="F:type 1 cannabinoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952:SF1">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000651700.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18238" checksum="BDB1098FE4923E5C" modified="2015-12-09" version="1">MTKVIEINLSFKSEKTNEFPAFKPDGFRFKTSEKTIKLKTDHSYKITIKTQPATDFNFLDVDGNRIVLHPMQPAGSGEYTCTWNTSGMPITTNNNRKDLVLVLSGTGGCIERTFQTKFYAENDNHGSSGEKLETVIWRCSVDTYGTIHVTEEIFKGKNANTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKS0</accession>
    <name>A0A0N5BKS0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKS0"/>
    <dbReference type="STRING" id="174720.A0A0N5BKS0"/>
    <dbReference type="WBParaSite" id="SPAL_0000652500.1">
        <property type="protein sequence ID" value="SPAL_0000652500.1"/>
        <property type="gene ID" value="SPAL_0000652500"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001065500.1">
        <property type="protein sequence ID" value="SPAL_0001065500.1"/>
        <property type="gene ID" value="SPAL_0001065500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF29">
        <property type="entry name" value="SHSP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000652500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001065500.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17710" checksum="41ACACE2F52964CE" modified="2015-12-09" version="1">MAGRWLTPFMRDPFLASSMKQARKLYDEMDRAFMMPTLWMDKSLTDSHKFAQCPEIINNAKEFKVKMDVSHFTPEELKVSVKNNFLQVEGKHEEKSDDYGTIERSFIRRYALPEGLKEEDVTSELNKDGILTVGGTKMAVEDEKTKEVPIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKX2</accession>
    <name>A0A0N5BKX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKX2"/>
    <dbReference type="WBParaSite" id="SPAL_0000657500.1">
        <property type="protein sequence ID" value="SPAL_0000657500.1"/>
        <property type="gene ID" value="SPAL_0000657500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="135"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000657500.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31207" checksum="10084C30C1D56FF9" modified="2015-12-09" version="1">MNNLLFVYYFLTLLGISLICDGRTFSISAKRQNGRIVYTYNGKDYPTQEAVMEQIKRENPGVIFGTSDSPSNQNNNGGYNRNNGYTNNGGGNNPQSFTRKDVTDLVGNNGYSSEVFKSIWKDYNADNDEKNGYKNMKERMLNESNEYRKHHRAPPLEINSTLAEMAQKYAEKLASTGIFAHDPNNRKDRTGENLGFGSALNIAATVVKLWYDENEYYDYGSKQYNPKAGHFTQLVWKESTKAGFGVAKGSKGYYVVCKYQPPGNVIGFFDQNVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLC0</accession>
    <name>A0A0N5BLC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLC0"/>
    <dbReference type="STRING" id="174720.A0A0N5BLC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000671900.1">
        <property type="protein sequence ID" value="SPAL_0000671900.1"/>
        <property type="gene ID" value="SPAL_0000671900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894766" evidence="1">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000671900.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46763" checksum="1C52108EECAD72E3" modified="2015-12-09" version="1">MNYNLMLKKLFVLFLLLITYSSIFLSAAEDYRYHCPVGHAKKDQNDDYVQCLPGDYSTHTCGDNHYCFFSGFNYICCPEGKNSRKKTIPLENFECPENSFTQLNENSQLINCKRNTDCNGLNSQCHNGYCCSGTQKIKPTNYRVTSKKKEKKVIEIDLNTLDCPHPFLTVLNDESLPTICDKLKPCSNPSEECLPVGKVSICCENLGSAGDADEDDESEETNPNIIKIYESSNEEKNEMPKDRENKINVLKIIVSTTKKVETTTLPIIENKPLIVKTEKLNEDEEKTVTIIETTTSVPKKIKLVSNTVTVPLKSIINYENFKENNKKEMVSLPIVRSKIHSSGPTKTTYDAIKLEPHYMGGYQKVGQEDTNNNKRAIVQKFLMDQIKKGWPYEDQFYWPEGYGDEKLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLY3</accession>
    <name>A0A0N5BLY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000692900.1">
        <property type="protein sequence ID" value="SPAL_0000692900.1"/>
        <property type="gene ID" value="SPAL_0000692900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000692900.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42257" checksum="0502AF433878284B" modified="2015-12-09" version="1">MYSGTIDSRRKTKSSDYCHNISSPVDRTVDSCHSCLTMRKFPYKLYASWVTATHLRQISSLYACYVSNSTLIMLVDYLFNFMYGQVLPDQFSQAIIKFLSPTMDEYPLFILIYDAESALTSDTLSEFFSSYRIGFHSNLQPSNTQKITSIKYRLKSNGRNEGHINSLHKTFQKADLLNILPFQRLQWATIPLNTSLSRTKNSNGGNQFLLPAEKYYLDWSVILLKLPTFEECAPSSLHTSYTLSDSILLSNNKSTVKVPESSLTTPPFFPPECQHALDESLDKSHVEIYLNSLQPSINVQKVVINVDCDYASDTASYDWYEREFDKKGKYPHSNLWKQIADLMPSSYWAYHCIRDVFPLHMIIRKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMY3</accession>
    <name>A0A0N5BMY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Defensin-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000726400.1">
        <property type="protein sequence ID" value="SPAL_0000726400.1"/>
        <property type="gene ID" value="SPAL_0000726400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000726400.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12441" checksum="F47CA2859D5AEEC2" modified="2015-12-09" version="1">MEKDVIYWCHKTINTFFKRHYYSYFNFLISHLVQDFFVMKFIYQLSVCLIVIMISLLSTRVTSLCANAGSGCHDTGCRLHGGLCNSACVCVQREGIPEIYSQCFGFGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNQ1</accession>
    <name>A0A0N5BNQ1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNQ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BNQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000752800.1">
        <property type="protein sequence ID" value="SPAL_0000752800.1"/>
        <property type="gene ID" value="SPAL_0000752800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000752800.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50964" checksum="1766E8B876103E29" modified="2015-12-09" version="1">MSTSEESLSSLTHSQISSLGEALAKGDLKYLMENLWVVRFLLILLGYSTVIVPCIILVKFVRRKFLTRPDYRGDNILWKALRIFAVGQPEYSLSVGNDSTTKCNKMELREEKEVKNEKKKFIDDCLMLSFYFLGIQSNFIIMGFIQEKIMTQGYSMIGNEGIIEKFGDAQFLVLCNRIVALFFCCAILLGIRRRQAPHVPPFYYHSYISLSNTLSSWCQYEALKFVSFPTQTVCKASKVIPTMIMGRLLRKEKYSKEDYAMAVCLAFGAAVFLLSQNNPTTTSSLTEHSTTISGVILMAGYLGFDAYTLNKQKQLFDTKPKLSKYQMMLGVNLFSAVLCTVSLLEQSTLFSSIEFMISHHTVARDAFLLSFTGSIGQIFIYMTIERFGPIVFAVIMTIRQILSIVLSTLYFNHGLSVIGIIGLIIAFGSILFSTYRRYFSNEQKKKSVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNT0</accession>
    <name>A0A0N5BNT0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyroglutamyl-peptidase I</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BNT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000755800.1">
        <property type="protein sequence ID" value="SPAL_0000755800.1"/>
        <property type="gene ID" value="SPAL_0000755800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000755800.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24832" checksum="374B2FA14C0892CC" modified="2015-12-09" version="1">MSKNKPTILLTGYGPFDHIAENPSKTIVTELRKEFENDKQNFLYHLEAKILPVSYKAVHDEMKQFYQRDDIEYFIHIGVNATSKYIIFETEAESHGYYSEDIEGCTPENNCCIVHKGEDPQTLKSTLPLQKICSEMNETNDYYPIMLSVDPGRFLCSYIYYQSLYHTSKSVFIHVPNVKLSDDIHFNDILYTIKKAIDNIIIHEEKAKHLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP33</accession>
    <name>A0A0N5BP33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein alpha-12 subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP33"/>
    <dbReference type="STRING" id="174720.A0A0N5BP33"/>
    <dbReference type="WBParaSite" id="SPAL_0000766100.1">
        <property type="protein sequence ID" value="SPAL_0000766100.1"/>
        <property type="gene ID" value="SPAL_0000766100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000766100.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42441" checksum="A5E8647D063A4FC0" modified="2015-12-09" version="1">MSSVLCCFGQQENGLKNSQPRKVVTKDSKNNKKIIKVLLLGSGESGKSTFIKQMVLIHGAGEFSEEEIKDYQNQIYQNIIIAMRILVSAKEKLEIEWENDGNKKYVELIVRLASTDIERTININKFLEVCPKIKKLWNDNGIKETFNKRNRFQLTESCKYFFDNLDRIGTVEYIPTNQDILYCRKASRGITEHFFEIKKIPFMFIDVGGQRSQRQKWFQCFQDITAMLFMVASSEYDQVIFEDRRTNRLVESRSIFETVVNNKCLKNAGVILFLNKTDILKEKLTQSNIKNYFADFNGDPLKLHDVQCFIIDKFEKTRQDRYRPFFYHFTTAVDTENIRRVFRDCRETILEMNLKMLNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQF3</accession>
    <name>A0A0N5BQF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQF3"/>
    <dbReference type="STRING" id="174720.A0A0N5BQF3"/>
    <dbReference type="WBParaSite" id="SPAL_0000811800.1">
        <property type="protein sequence ID" value="SPAL_0000811800.1"/>
        <property type="gene ID" value="SPAL_0000811800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="376"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000811800.1"/>
        </source>
    </evidence>
    <sequence length="821" mass="94762" checksum="E7C436F2CC908F75" modified="2015-12-09" version="1">MIGKGLNPIDIRLPQSVVKGAVKLDPSISNYLVKPFKFPTDPRNLSCYVQYDKSTDTIAEFLKNVTRQLELPEVDDVDSYSLVFEDNGVFVSEERVDMLKQGFILILTASPGNYVQFVEKALETGSEYSQETLKTLQLMERLAKDKVFLEAYEKVSGMEKIILYIKSGKFSQNGISLSSLFNIFLTLMSTLEEQNSDRARAYWYGLTNDFISEVASHISGRTKLESNESLTASLNVIDFILKKCQNSQLCQLQREVPFESLIMHLEKSDKRIPVSILNLMSSLYWVADETLKIEILQILKNNAFRSMVCKLLKRQDSITVDSELTKPLLKLQDIIMSDLSAKALKKPTDVEIEIIRNMESLNPCIFDGNVYHVSPSKSSLTTTTFGVDEDDISTSSFSDVFPTLVIDWSEFTDLVTKTPPGLLVLEAILYFDEKYPQLLRDINTENIVWQETSSWPFPIVSVYLVSIIIDLFSIIPQKPDNSEVISKLCDKFKRSSTLSRDSNETFSKEDKLHLIFFTVESPFHELFALSVRLFRRTWREMHASHEDVIKVLKVVKEQLERSLDCNPLSIKDYDNNLQKYSYYQMQKIWELERFEKDQSELQSDAIRHLTPKLRLEMEKLVKQNRKNEMKKGCVFFKVPKDKTNVKITSLGYWLWKLDRNERFLWYQDVDNDTCLEMDMKKAQKIPVMEITSCIFEESYAEYMLQTYGRKATFKIPSRGIGICINGSKDPDYNMALNNQKVVNIWIDGLNSLLHDKLITAESIVEVKKLADFDVKVRLMYIDRLPEIRECEIGSKLERVVPPPPSDLSWIPTDGNDRVHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQH7</accession>
    <name>A0A0N5BQH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQH7"/>
    <dbReference type="WBParaSite" id="SPAL_0000814300.1">
        <property type="protein sequence ID" value="SPAL_0000814300.1"/>
        <property type="gene ID" value="SPAL_0000814300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="175"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000814300.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="37985" checksum="4427EFE1C1785B90" modified="2015-12-09" version="1">MAYDFAVTYSMLKMGEKEFYSYCSNIYQTKDQMMKEIVKDHPFVSLSKIVLLNIGTYHNSENFQRVVQHIYENPFPEFVNRSLSPVVIKVFCYHGITYYNCLYRVFEDYEKAKIYARLMDIKVKFDFKNNYHPKAPKELDVKKKVGYFRFSDRVWRNVWKDCYYYKCFAENGFAQFKLRLLNEMNYYRMKHNAKPVKVKKIATQLAEAYLERILTTDGRFTDKKLLQNYEASPYYFAPLFFKKWYDESKHYNYKTKVAITGTEHFTAMVWKAVKYVGIAVREVNNIVHMFVVFEPLPNDVKLFSPNVQKRKYKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQJ7</accession>
    <name>A0A0N5BQJ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000816100.1">
        <property type="protein sequence ID" value="SPAL_0000816100.1"/>
        <property type="gene ID" value="SPAL_0000816100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000816100.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32730" checksum="BB696EC148C327A1" modified="2015-12-09" version="1">XLIPAFKNYYLLKHHTIPCYDARGRCTYTVYVSPRNESIVVILSSDRGFTKIMREAISKSQNFYTFEGLGFVNRNFATSFYKIWPFLCDIFREPKVFRYKVTIVGYSFGGALATLAAIKLRYAQYRIGQDISLYTYGAPRVGNPDFAQKFDEKIPNSFRVVVDKDPVPHFPKCSLVMSKYFKFSPKLTSKVCNIKNRLSYYHTGTEIWYPKGTQNLNNYYLCLGNPKNEDRKCSDMYHFDKTSLNQYKFFHYIYYNDVIQTCKSIFIPIIDNNCGIVPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRB6</accession>
    <name>A0A0N5BRB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transcription factor HNF-4 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRB6"/>
    <dbReference type="STRING" id="174720.A0A0N5BRB6"/>
    <dbReference type="WBParaSite" id="SPAL_0000841700.1">
        <property type="protein sequence ID" value="SPAL_0000841700.1"/>
        <property type="gene ID" value="SPAL_0000841700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="142"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000841700.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48561" checksum="C2AB12A79F04E902" modified="2015-12-09" version="1">MNPEIVIEPCAVCGDKSTGTHYGVISCNGCKGFFRRTILRNQTFTCRFNETCTIDKNFRCACRFCRFKKCLDVGMKREAIQFERDSNISPGMRRSNSLDGMDNSGPNSNKMNGSGTPSPTLMGSHDNGNVVNNMMQPQPVRIKNEVIDLLMEMEARNNNALCMHYRSSVITSNLINNSNVNGGIGSGSIDSVRCTTEELNEISRTTLLLMVEWAKNIQPFPELPMEDKIILLKNYAPQHLILMPAFRNPDSTKVCLFNNSYMTQEPKGGVELNSFAAFKTSSITPRVLDEIVWPIRQLQMKEEEFVCLKALAFLHPEAKGLKHENQIKVREARNKVLKALYAFISAQNPTEAPTRYGNILLLAPALKALTQLLIENMTLTKFFGLAEVDSLLSEFILDDLNDQSNTPVALQQHLQGGSISRINGTTTPNEDHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS97</accession>
    <name>A0A0N5BS97_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS97"/>
    <dbReference type="STRING" id="174720.A0A0N5BS97"/>
    <dbReference type="WBParaSite" id="SPAL_0000874100.1">
        <property type="protein sequence ID" value="SPAL_0000874100.1"/>
        <property type="gene ID" value="SPAL_0000874100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000874100.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51632" checksum="46A1B28D922D8FE6" modified="2015-12-09" version="1">MDEIYYNCDFYNNNTNLNYVDEEDGRARLIALISGPFSMAILLFGIIGNVNILMVIAHVSTLEKFNSRFISSVIILALCNTITLISSIEVYVLPYCIEYFMGYNPSPSMLKPFAFATSNSFRTASIWMVLYITFQRFRAVSQPFRERKRTSTVKIRRSQRFATRNVIEISEEEGKVKRSNNKSSINDEFSFPLLFMQSFDFNDFKIPLLVVFVAIIYSIPNYLEVKIIRCPSGDTKIVQTALRENWWYRVILRVIIKSLFEMSGPFVLVLSLTIATQLIIARSMRQRKLLTGQLERRQQLENEALLKTSECGITHDNGEMLKINSILSGPMQKQRSSARQKLACHIEKFHNQRQANENNINITAVMLAIKFLILHSLTIALDTLEAFEYTNVEFFNLLVAISNLFVLLDLSTNCLLYARWKRKNRENGFIRKGLCDVMKLILPHKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTY4</accession>
    <name>A0A0N5BTY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTY4"/>
    <dbReference type="WBParaSite" id="SPAL_0000930800.1">
        <property type="protein sequence ID" value="SPAL_0000930800.1"/>
        <property type="gene ID" value="SPAL_0000930800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000930800.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26451" checksum="4176328BD998B5FE" modified="2015-12-09" version="1">MFMFANLILFKQLPRIALKNCIIKIMKYCITVIVAVLALRCYGDNYYRMNNPLYMSLTSAQIQQIKWIEDDDTISQNQIKQKISDYLNTQGGNLANLYNQYVQNQTSLLNEVKQTRTELINNSTMSDAAKNAQRQIDQISSNESLSKNDKKTQIRQVKSNLTQAVLNELENFEDGRMNPMGSGYLVGKINNGLRNYDHSGERIFDFDFDDIYEIAKRSINTPASRGGRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU24</accession>
    <name>A0A0N5BU24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BU24"/>
    <dbReference type="WBParaSite" id="SPAL_0000934700.1">
        <property type="protein sequence ID" value="SPAL_0000934700.1"/>
        <property type="gene ID" value="SPAL_0000934700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF141">
        <property type="entry name" value="TRYPSIN-LIKE PROTEASE TRY-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="567"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000934700.1"/>
        </source>
    </evidence>
    <sequence length="1711" mass="198166" checksum="4A5E61A15BEF5C1D" modified="2015-12-09" version="1">XKTTICNGILVTQLHVLTNFGCIEGIEKLVEQQSDYNQLYDRYQVRIGEHSSKDVCDSDSDGILNCSSKVLLRYINVLHIRHPAMANDLKYGVIELNRPVTSIPHACIYQYQMDFLGLEERRKVENVLSFMWGVNYNKTFNNFELNAFYYKETFDFKNRRFANSFGCKIREDYTMVIEELEHGRWKSILKGAPLLRKIKGNQFGVYGIGEDTCVKNFNSDIKHIQEMFFVTFKSAQYFLFDALNDVNHDEENVGNEFHDISKFYDKDTCGKIQKENIPHNTDSFTNEVSYPWILTIVKGGRACMGTLISKMHVITSYECIYSTLEVVPKRKFEVHLKGVLVMQSKKYCTYWRRKGSIIIFSKESPHSCYNYDIQYREVYQIFSTNSRNYKDLSVILVLKEPFNDVPHVCVDEKLDPLNENEILKKYLVYYNTALLDDLKEIVFLAEYPLTKVSQSQLSLNDHEISVTDDNSKYICGRSTGSNTFVKTYDDVHYLYQIQKGFGVCHDKTKSFYYDTEYDFIKSVFKKLPMIKYDTSLPVYNLKKLQYYDYENCGKSNINLEVIYEFLISGGSDIYDIKAIPWAVQMTSKDGACSGVLVSYIHVITAAHCILNTDNLSFWYYDKNIAYGTEIIISSHCNERHNADGKCINNVEIQKRGINRVLYNFKNGLRRHRNDIVVIELDAPVVGVTHICLPFLHDNYKFDERKTLITFGYGRNKNGPKATDINHNRRLKRFIYSNPDSVRNCSKPSVPVKSKEYLCIKVNVHLGLCVGDSGGGLIQKTSDNRYILVGVNSISSSCVFGESSKKEGDNMFVKLEEYKDEILNFMHETKTYYFGKKSDFLHGFELSVKQTGFSFAYELGLFSSIPWMARIVDHNNFTICNGVLVTQLHVLTNFGCLKGIEELIKQQSEYNYLYGRYQVRIGEQSTRDVCDSDSDGIFNCSSKVFIRYINDLHLPYPVLNDGHKYGVIELNRPITSIPHACIYHYQMDFLGLEEQKKVENVISLLWGIDRFLNLEIFQLIAYFFKETFDYKNKTFADSFGCKYPEDYQMIKEDIKSMPWINIFKGAPLFRRVKDNQFGVYGIGEGTCLKNSNKIKHPQELFFHTLNSAQDFLFNSLNEVNHDKENVENGFYDISKFYDKDTCGKIQKENIPYNTESFTNEVSYPWILTIAKGGRACMGTLISKMHVITSYECIYNILKVETKILFKDRLKGVLVMQSKKNCTAWKVNEEEKVLSGNKSDDYCNNFDIQYREAFQVFHPASSNDKDLNLIIVLKEPFQDVPHVCVDENLDPFNDNEIVKKYLVYQDTVLSDNQKEIVYLAEYNLTQVTELKLGLVDHEIFATDDNYKYICGTSTGSSIFLESHNNVHYLYEVQKGFDICNDRTNSFYYSTDYDFIKTVFKILPMTKYDTSPFVYNLKKLQYYDYKNCGKSNNNIKAMYEFFISGGYDVHNIKDIPWAVQIINKNRLCSGVLVSHRHVITAAHCISIMDDLPLWYYDKDFLNDAEIIIGSHCNEILNDDGECINKGKLQKRRVNRLLYNFKNGLRRHKNDIAVIELDVPVVGVTHICLPFLHNNYKFDERKTLITFGYGRNKNGPKPTDENFNRNLKRFVYTMPNSIKNCSIQRVPVNSTESFCLNVNANLGLCHGDSGGGLIQKMPDNRYILVGVNSRGKSCMHENFTVMSNEGTNVFTLVEEYKDEIINFMHETKTYYPKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU64</accession>
    <name>A0A0N5BU64_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU64"/>
    <dbReference type="WBParaSite" id="SPAL_0000938500.1">
        <property type="protein sequence ID" value="SPAL_0000938500.1"/>
        <property type="gene ID" value="SPAL_0000938500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="43"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938500.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="50479" checksum="205B3792589CCE98" modified="2015-12-09" version="1">MFIFAKHYDLRNHNSCKMCKFSIFTFILLKLYPFFMYVNEDNQKINKRDIFHDTYKPWKFPISYRIEKELQFRGTVIKKALHEIQSNTCIQFYENITLVNDTQGIVFRKSSEDCSSGLGLVYSNQTQIIHLTDECSKSKGVVLHEVGHALGLVHEQSRTDRDKYVIVYKNYIKESDYVYFKIQNHTDFKNFSTGYDYGSVMHYAPYDFSTSYWHKALTSKLHIAYDKMMGQRSYMSFNDYKKINFAYCNKCNNTTTTKKIKEKNKEKVNGKENKKGNKNETENTIQCLNGGYFHYDNCTKCICSFGYTGDLCNRIVESSKECNTTKFNATSKMFYHWIAGPYKCYFYLTAQKRKKIQIVIYYSSAPYKDVCTEDISHQIKYLKDKGSTGLLLCSWHRDIVNVTSENNKALIFFNGNTDNALIQFGFREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVF0</accession>
    <name>A0A0N5BVF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVF0"/>
    <dbReference type="STRING" id="174720.A0A0N5BVF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000980900.1">
        <property type="protein sequence ID" value="SPAL_0000980900.1"/>
        <property type="gene ID" value="SPAL_0000980900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000980900.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11542" checksum="4592D1486627E9A2" modified="2015-12-09" version="1">MNSTMNMRIKINKHSISKLVNHKKSWKFKDLNIFLDGDIRKTNATIMNQTIEITKGLVTMGLPRDSVDYLLNELNVTTFLNQLNINLFDNEELKNFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWC4</accession>
    <name>A0A0N5BWC4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWC4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWC4"/>
    <dbReference type="WBParaSite" id="SPAL_0001012200.1">
        <property type="protein sequence ID" value="SPAL_0001012200.1"/>
        <property type="gene ID" value="SPAL_0001012200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001012200.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35536" checksum="F01528D717CA4D53" modified="2015-12-09" version="1">MTISGVSDKKETLKQPETLTGYRYFLPSEKTIKGIVIGGLTGAIEICITYPTEYVKTQLQLDERSVLPKYKGPIDCVKQTVHNHGFFGLYRGLSVLLYGSIPKSSFRFGTFEYLKGKVMDDKGNLTPIQRLYCGLGAGFSEAFFVVTPMETVKVKFINDQTLKEPKFKGFFHGVRCIVRQEGMKGLYQGLTATMAKQGSNQAIRFFVMETLKDWYRDGDNTKSISKPIVGMMGVLAGAASVYGNTPIDVVKTRMQSLERHKYKSTLDCAIKIWKNEGFFAFYKGTVPRLSRVCLDVGITFVIYDSIMEFLAKHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWI9</accession>
    <name>A0A0N5BWI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWI9"/>
    <dbReference type="STRING" id="174720.A0A0N5BWI9"/>
    <dbReference type="WBParaSite" id="SPAL_0001018300.1">
        <property type="protein sequence ID" value="SPAL_0001018300.1"/>
        <property type="gene ID" value="SPAL_0001018300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001018300.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="77657" checksum="7F6A03C669E55782" modified="2015-12-09" version="1">MAKINGEKGKFICKHCNEVMDVSMIYLHVRSIFNIPLYKCHQCHFSTDHAFHQDHHSAVTGHLLSDEKDLNPVWENIVNYVATTLMNSIVNNSKSKKATMNISKPHETRRIDNLENAISGNTANVQRKSGSKRRKRFFSNTIFLINDMSFKYENKNNSSEGKLETLDNHIFLDVRFVETYPGAGLPKNKHFTPRPPFSRNKMVLCQKCGKEVRENYISRRKHVFLNHQDDIMHKLKDIEILKRTDILFKGFMVIRDCFPEYAVCSDFQCVDCGYYYSSMSGVRYHVGLTHQKSIIINCPFEDCEFKTGGDYHAKDHIRTHLKEVVDKKDKLSINNLASYVSPQSYTKFNSSCEVGNKIIKSIVKHYIPINISYYDNFQDDFKSDLSEFKKSYLQPYILDGLIKDNHNQGMNESEVISSYNDTNEELDYESDVPEENMLERSSVSFKKRKRDFSNSVGSDAVFSKEIASKSRKTIYSEEPTSSGLPIIKDNFLKDSFNQAKKTKNNDVSVENPSVPRLGNKENAGQAVENSKLVKFKKEVPLFETVARNLLQNKGNNKIKEEIVPRPNISLNVEKVKTGMTALTAESRVEKPYKDFVYETYSTRGEEMRAKLNKRDFSRERSDVKYPSHYNDSGRHSLASHNDDGRKNLSMSCSYGNSSKYSKSTYNQKYFSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXJ2</accession>
    <name>A0A0N5BXJ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BXJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001051800.1">
        <property type="protein sequence ID" value="SPAL_0001051800.1"/>
        <property type="gene ID" value="SPAL_0001051800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001051800.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="47935" checksum="F10B1AEE325E6EBF" modified="2015-12-09" version="1">MKLSTFRRAKEHYNLLVLGAGAGGLAVSSHFSRTLPKGNVGIVEPSSVHYYQPGFTLVGGGIFPKSHFTRKEELLIPSNATWIKDSVGRILPEKQIVETSEGKEISYNFLVIATGVQIRFDLIEGLEDGLSMNDNKVICTYSPNTVEQVYKAFENFEKGRAVFTFPNAPIKCPGAPQKICYLFDDYLRSVGKRENAEIIYNTILPRIFAIEKYSNALTKYAESKNINVNYRTNLSKIDPIKRIATFDILNESLLPTGEIKKIEYDLLHVGPPCSPVEGLINTAKNNDGLTDKVGFVDVDKNTLQSKKYSNIFGIGDCTNFPSPKTAAAVSAHFKAIKYNLQRVMDGGSVKQIYDGYTSCPLVLSRNKCMLAEFNYDGPIETTPFDQSKPSYVAFLGKAYGFPKLYWDYLLKGYWGGPSTIRKILHLGMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXQ5</accession>
    <name>A0A0N5BXQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001057600.1">
        <property type="protein sequence ID" value="SPAL_0001057600.1"/>
        <property type="gene ID" value="SPAL_0001057600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895292" evidence="2">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001057600.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="22027" checksum="2C43A0EEF5AD6191" modified="2015-12-09" version="1">MYSIVLIFILCFLTNNSVCIQGDYKNVSISVYVRNSSIPHIFHEVLDNYFDYGFEFKKKHKNFSIMEHENKICHYVFIIDFNVIPIDDGNYKCTFIYWNTKYNNVTIKDNKNILYLKDQDISDEHVIEKIVKNSLIFSDADERCTINFEFSMDYLYKKKLIFKTGYIVLILFITLLPLAIVIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY12</accession>
    <name>A0A0N5BY12_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY12"/>
    <dbReference type="WBParaSite" id="SPAL_0001067350.1">
        <property type="protein sequence ID" value="SPAL_0001067350.1"/>
        <property type="gene ID" value="SPAL_0001067350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001067350.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="43223" checksum="5A27EAB66653D401" modified="2015-12-09" version="1">MSNYSENKDYILFKVTKIFPFFSVDVGLPTLCFHVFLSIICYIIYIWTLVCLIKYKKNLLELNETFCNTTIVGGFLDIITHVESVAFNIFNLYPPVSELLKDLGDLSYVWTIYYSSMYFFPFCQFFLCTYIAFQRFVIIFYPFKGENVSLFNFLFFLMTLKFLKATFIPFLVLMFVTSIAPTWYLWNASIFFNQIPTIFTNGYVLRVLNYKKKDWMNNPSNSRNSIIHYSTFIGLAFFFNIISSGKILIYNYKQVKKSRENSKQKKVNLNMLLYSICTTFTQFLFVAINFVWYFSSTTAEDPSFYYLCYVLRLYIIHLICLTQPFYLFWLSKKVRALILRSVGVKTEISNMVGKSTTRARVTVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYI2</accession>
    <name>A0A0N5BYI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYI2"/>
    <dbReference type="WBParaSite" id="SPAL_0001083600.1">
        <property type="protein sequence ID" value="SPAL_0001083600.1"/>
        <property type="gene ID" value="SPAL_0001083600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895119" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001083600.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13836" checksum="E448E34F628D00AA" modified="2015-12-09" version="1">MNSLSLVTLVSILINISFGFKTNCTSTVGEPCSVWLEPGEPAYEIFHLCLTDSDKELGVGLLKKGADLSEIEKENILIQTKVSEDAKKTFFTSLNDRPYASNRNIVIVPNDSRMGSRLNKQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYX5</accession>
    <name>A0A0N5BYX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ephrin RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYX5"/>
    <dbReference type="WBParaSite" id="SPAL_0001097400.1">
        <property type="protein sequence ID" value="SPAL_0001097400.1"/>
        <property type="gene ID" value="SPAL_0001097400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895131" evidence="1">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001097400.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29730" checksum="F6BBFA8A042FED0C" modified="2015-12-09" version="1">MKRLLQLVWILALYSITVNSVDLKSLFNESIPYTPPDHSKLVKMYNVQSNTKIIAVKCYSSQPNRQEAHKGIDLQYNPDGITYNLRQIKNLEEENYVWVVSPISNSGKKYINCGELKDKNTKHPVGYNYIIPSGDNTNKLKEKELYPPTGQNYFTFHYSESTGLRDYDVMPKKFEGDITYVFKVVDGRFDQVLEPDYIIKDPSPHYSSNQKVVVTAHVTGNITDKNDKEGKDIENSTDKIGAFSSIIFSIMFILNRIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZB9</accession>
    <name>A0A0N5BZB9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZB9"/>
    <dbReference type="WBParaSite" id="SPAL_0001111200.1">
        <property type="protein sequence ID" value="SPAL_0001111200.1"/>
        <property type="gene ID" value="SPAL_0001111200"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001475600.1">
        <property type="protein sequence ID" value="SPAL_0001475600.1"/>
        <property type="gene ID" value="SPAL_0001475600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001111200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001475600.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21053" checksum="E983003A2B08386E" modified="2015-12-09" version="1">MYLNTVWADTNLVGCGFAQCRDVQGVYGRGHHYVFVCHYNPQGNLYYVTGNGGMYTIPAFKWDVNGKGRCSECPSDAPDCYNGLCYKAKPSDGNSLNNENLDNITSTTGTTTTEISTTISTTTVALDLEDEGSETTESESTTESTTTTTTSSSSFFNGRQFRKRRVRPTQSYRDLYYRRRNNNLIKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZY6</accession>
    <name>A0A0N5BZY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZY6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZY6"/>
    <dbReference type="WBParaSite" id="SPAL_0001132350.1">
        <property type="protein sequence ID" value="SPAL_0001132350.1"/>
        <property type="gene ID" value="SPAL_0001132350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001132350.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9899" checksum="1C55414AFAF2D60A" modified="2015-12-09" version="1">MTALSTAKSFTSLTTNIQQQSSSLQKKASISSSNISNHTISKLNNNRKPSALLSLNRILFFRNQSGKSRISKLDRLPDYLRGTMDRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0E3</accession>
    <name>A0A0N5C0E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0E3"/>
    <dbReference type="WBParaSite" id="SPAL_0001147200.1">
        <property type="protein sequence ID" value="SPAL_0001147200.1"/>
        <property type="gene ID" value="SPAL_0001147200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001147200.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56580" checksum="C7C51DCC6BD6BEAF" modified="2015-12-09" version="1">MRKKTTKGEFCYYVCKKEKCKRRFRTTFIPTANIYIISSNNVSHNESCFESKKFTIDEQTKKVVLDMYSSNATPLQIEVFLRSQQFTLNLSLQQIRNMCYTNNKKDTNSTDHVRDIIEKIKQENKVKVIYDNIDIESNYGEFSLLLSTDSLLESFKKNGSTLHWDGTYKLGKIKSICHIFGYVSRTNHFVPIAIGISTKEDAKTIENMLNTLKNHGILPKQVMGDCSLAFTCAVKNVYGNIKRKCCFFHVSQSVDRKFKNSKYNNLVRILSYSFDEDWFNALWEVAKKSYLNEAEDSEFQEYFENLYINTHKYWYGPLVKTNNHLESYNRSIKCIFNRRSKNLEGYFGGVVELIIYANSKILESDDDEFNKITRKIYKEAFELKTLNVPIIRSGPYRCVAIGSSITNEELKNMLNACRSKSWSTIQDFQKLISIGYLNDGTMCTCMVNGIQCAHIKYTFDDIPHEIISKPLKVRKKRKNMGYALEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C113</accession>
    <name>A0A0N5C113_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anillin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C113"/>
    <dbReference type="STRING" id="174720.A0A0N5C113"/>
    <dbReference type="WBParaSite" id="SPAL_0001169200.1">
        <property type="protein sequence ID" value="SPAL_0001169200.1"/>
        <property type="gene ID" value="SPAL_0001169200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="2">
        <location>
            <begin position="558"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001169200.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="98880" checksum="635F1C3D07D50BDD" modified="2015-12-09" version="1">MSRNKDFPHNRGYIFSANSTTRKYDSEHEPPSDSMDEACDAFETLSVSADIYDMQIRTKNRRSCRTSKRKTTASKQNNEDEVVSKKVGDYKYPKVVELSYMVNNNVGNSGVESVGTYQGNRSYDFCVKNTPQTTPSDRIHSSDWSTFDPYKLKNISETKVNNIITESLFQSSPEKTKNTIDCIQHSEDEEIIMGPTDSPQVVENNNTSTKNTTSTYKKMTFIRRFLSKFELKYDKTKKIKEEGNVGAPKNKEKCNNPSIVNKNIQCSSSKVFASQNQLNNAYIVYENSGSPQQVSDNEKENCLHNRMSGKRCLETDEWNDKTSSIISSSKFKTPKLTPYQKKVYDENCAPKFSPASRYIPDSPYGKILAVYKGDTLSIVSSIGTIALHSTAPGIYDLKPIAHSTPFQTPTHSLAKGRNGNKCRGTILPFEEKDKISDNTTYSKGKFSLNSNNSHVPSLTAPSYLTHIPEEMYVRKLTTIKNSIRKTKRIVYESEKIISDCIKKSNYNGKDVELTANRTKLIGVSRIESLKDEYQKTKILMNIANLIPRINSKFLSIYTINEIKLELNRLFCFKKTQENLSYVFFIVFKSANNVIGTQMKTVEDLGSVRLRQIKFFDVIRFSKLPINFVVLLEIYAMKIGELDRTKLSRFKKSVKDFAVSIFRPSSKKSTLISINENNTVNPNDSLHPKNQIGFEHFTQCGVLRLNRDTIGNQKFYLEEAKFPLEGTISLNTECSSLPQQIEVAYSGFLSIYNGDDTKGYSIKMWTIVKRSIMKFWKSCEDEYGGQSPVSIIDMSKITSPQLERIKASEFGYKEDSFCIDVICESLDLNCVYQHKRIFLSSECSNDCENWLQYLNGILKLIRHEPDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C190</accession>
    <name>A0A0N5C190_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C190"/>
    <dbReference type="WBParaSite" id="SPAL_0001176800.1">
        <property type="protein sequence ID" value="SPAL_0001176800.1"/>
        <property type="gene ID" value="SPAL_0001176800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF8">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895189" evidence="1">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001176800.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35022" checksum="2EFD66C6A0B9AF30" modified="2015-12-09" version="1">MKTTITLLILLSLTVAINGGIIKRIKNLSQREVKAYFDYDARYRMMPLGGAAYGPKDKIQDCLDNVYGAGNATVTKIVEVICDSSETDTCQGYTGVNHNEKAIIVAFRGSEGNLQILLEGSDALFSRKVSFVTGGKVCHYFNKAFYDMWNGGLRDDFLTLKNQYPGYEFWFTGHSLGGSLATLAAAEVIHAGYASADDVIVITMGEPRTGDHEFAKNYDKIVKYNYRVVHNNDPIPHVPWEFIEYRHHKQEVWYKNDMSEGSPFTMCPSDESDRCSNSVLGLSADDHAIYFGKHMNNFGKEGCPGLVVPPPPAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Y1</accession>
    <name>A0A0N5C1Y1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Y1"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0001199900.1">
        <property type="protein sequence ID" value="SPAL_0001199900.1"/>
        <property type="gene ID" value="SPAL_0001199900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF26">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001199900.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39981" checksum="59C28D5B573C4300" modified="2015-12-09" version="1">MVNSFSQLRNNLIEISNNQNVAFIKSAKSFGQLFKSSLLKVSVDTMAITALPLDCWLKERLKSWVQLSGHEGTIIPASNHTLWKKQPSSNTIEAQAYQKIMKDPWLAGLTPKYYKEIFHKNESFIEIQDLLAQFSDTENRAIMDIKIGQRTFLESEVSNQKKRADLYKKMIDIDPNEPTPEEHADGAITKLRYMQFRERESSTASLGFRIEAAKTSEGELKKNFKKIKTPEQIKETLLNFFEDYDTGKIRRQVLERLYEMRDKIEKSTFFKYHEVVGSSLLIVHDRNKVGVWMIDFAKSNQIDDGSPLDHRRPWEVGNHEDGYLVGIDNLIKIIESIDERNENIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Z9</accession>
    <name>A0A0N5C1Z9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Z9"/>
    <dbReference type="WBParaSite" id="SPAL_0001201700.1">
        <property type="protein sequence ID" value="SPAL_0001201700.1"/>
        <property type="gene ID" value="SPAL_0001201700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001201700.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45725" checksum="EB564DB8A4460C80" modified="2015-12-09" version="1">MPQHRRKVRSQSRGRWSVNLKVSVTTEGPNNGLIIQQGLIPQSSYGNISLPDFNSLPTYSFNPTQPNIEMLPSTSVDNLNTSIQSLNSPKPRSVSEEPLHIQTSPSPVIVNNHPVQVQNNKSTTLTTVEVFRAPIDEEVQFYKLPPEPVSITGQPQYIRAHGPAYETWNHVRTETLIDDPAPIIVSKSVQWKNDLEERLTVSSYDSYNDDLGSVTREEIEYNDTPPKVYGLNKRSDPYGKQSISSDYNYPLPEPSPIHYHVSSPTASSAYTENRSQSPMVAHILRQQKIIQTESTPINGRKVNGNERILETNGYREGDLQIKPLTIDVDGKYLQNNKNNLSLDNQFFVSPSSSIKSGKPLVPRGRSPSILKNGSSRTNRSRSPSWEEYNRSDLYKTKDVLGNVIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C203</accession>
    <name>A0A0N5C203_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C203"/>
    <dbReference type="STRING" id="174720.A0A0N5C203"/>
    <dbReference type="WBParaSite" id="SPAL_0001202200.1">
        <property type="protein sequence ID" value="SPAL_0001202200.1"/>
        <property type="gene ID" value="SPAL_0001202200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="409"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001202200.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="82611" checksum="F156E07A1404E95D" modified="2015-12-09" version="1">MVIDQVLEPCKEYCFAYVDDILICSKYSLLNHFKDIRSVLQRLIDYNLKINFAKCTIAAEKLDFLGFEFTAEGRKPSNHALEAIDEIPAPRTLRALRRLLGKINFHRVFLHKISETEIPLLNLLKKNTKFTWNQECDLALQKIKTQLKQVCRLKLPDFSREFILHSDASQDSNAAVLMQQELDGTLRPIAFYSKRNPQRSNKCPAVYLELRGLVEAMQKFRIWLLGGFTRIFTDHKPLKNLILHNTDSRLYHYINIMSEYAYELEYLPGCKNLVADCLSRTHLKRIECPDNILITNPPIEDDIELNEQVDNSHESTINQSSDKPVDEIPKNLNELSRSDEPTSEEKLQLFQFFHDSLGHPCYERIKPLIQRRRSWRNLSKDLKSYLSKCSVCLQRNETHAIKLPNAMISATRPLESMNLDLLGPFPQSDEGYKFILGIIDVNTRYAIMEPIRSSSSNDILTALENVLFFRYGSPIELRVDNASYFRSSLFKTIKHLYGTTVNYGTAYLHESSAPIERLFRTLQNTISKLPNKSYHSWHNLVPKATFFYNSTIHSTLKCSPYKLWHGYEPVFKYDIENCKTNLNYIVDKDLSEHERQASWKLAQMMSDAMRDEANIPTPKTINKDDSTTANLKKLSLLTPGTKVLVKIPQLHKKDEIGKFQMQYESGYVVIKRENNSFYVRKHNRGRCRKVHVNFLKIDTSDGNSQDNDNLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C295</accession>
    <name>A0A0N5C295_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C295"/>
    <dbReference type="STRING" id="174720.A0A0N5C295"/>
    <dbReference type="WBParaSite" id="SPAL_0001210600.1">
        <property type="protein sequence ID" value="SPAL_0001210600.1"/>
        <property type="gene ID" value="SPAL_0001210600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="262"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="532"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001210600.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="88934" checksum="1DA34A880D02BEE6" modified="2015-12-09" version="1">MEFPDVTHIADNFEKSEICQKLSPSEHYKDTCRGQVSAYPLEIERTAVAYRYSVSISLTRENFRKMLTSTNDLEVKVIGSKQARRETCMTAVDHTIKDLEIPDIQYCYDGVSNLITNKEIDNTEVVIPGNRFPEECHGLIRKSSVSVEVTRCTDDFLIPIGQKDILLNDALSQKQRLIYNCLEMITSQYALNNKKYFSNNNRSFYMASREFDEDIGNGKILKPGVCKSVRFIESNDQEQVRAAVFLDMSKNVFYKDGNLLNVIMEITGKNDVKQLTSTDYNYALEYLEGVLVTPSYRNAGDSFKLKEFSKESLKDCYFKGRDGENVSIIEYLENTYRIKILHPDIPAVVVKAHGQINYYPICQLNICPGQTVSIQKMDSESSICQQSNNTVKPYIRKNEITKHLMGLGLLDVNNNSVMKGFGLKLLPRAINIKLKIREPPQIFTGDGRVYPDNKGTLSDAFRQRFANPAEIKKWVLAYNRSVTKKNAEEFCRELLHMARQKGMTIYDPVEIVGLLDGPQELKKFMKAMADEKVEFIIHLEPKAILSHDLLKYYETKYNVLTQQVTKELVENILTKRQRQSLGNVINKMNLKNGGLNIITKNESAAIRMCMSNNENFIIGYSLSHSKFNGDPSVVGYCGNFAPNPHNFVGDFFFQCSRKHQIDSQSLENTFVEVLKRRAANRKGIAEPPKRIVVFRDGLTDVQFKDAIHREISALRAACERFQSGYKPSFVMIIVNKHHNKRFFGIDSNFISTNFAPGVVIDTGCTRADYTEFYLQAHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Z9</accession>
    <name>A0A0N5C2Z9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">60S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Z9"/>
    <dbReference type="WBParaSite" id="SPAL_0001235450.1">
        <property type="protein sequence ID" value="SPAL_0001235450.1"/>
        <property type="gene ID" value="SPAL_0001235450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001235450.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19467" checksum="C2B69F2976C5C552" modified="2015-12-09" version="1">MNKNLGIGSLNLIPKLQKSELLLKIWLYLIYRIFWAGITGFLHCNYRKVGFARVMMFEKPRKILERKPVAQSFVRFGKIFYLKGRLKGFLALVMGFGFRCGKNIYTIPVSGIFTCRYKSRGHVVILVTEKPNRLFQWHPIARLEVNYQSRFYLKAHAKRRHKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C335</accession>
    <name>A0A0N5C335_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C335"/>
    <dbReference type="STRING" id="174720.A0A0N5C335"/>
    <dbReference type="WBParaSite" id="SPAL_0001239000.1">
        <property type="protein sequence ID" value="SPAL_0001239000.1"/>
        <property type="gene ID" value="SPAL_0001239000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="726"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="84"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="409"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001239000.1"/>
        </source>
    </evidence>
    <sequence length="999" mass="113718" checksum="15C468D15D638A30" modified="2015-12-09" version="1">MSRSRLSSSDGEKNKKELKVNKKISIIETYNNHEKYDLLKNVFLKSQNVFVGNQDDSFKGSLKNLIENVKIPTPAIMSELLLYKEILYDSGDFETLWYESCRHIKYCQVVEGEGTRLSKPFITLMNIQSLFQIRNCFKKGVILLDLTVSSYKDLIDNVTSVCRQRNIIDDEECTLLRSIFSAPKYHFVNNKLRYIDRDSRYSGNKEAKFIDSSDDDGSIKEELDERVSLKDDKEEDDRFMSKLQPNTESSIIMCGVVRRLTHPVCIFVRLKTKTQFYPEIPSHPVPTRFVFILLTPNENYKHELLYIGRTLCALLADDIFKNVVYNCTTNLIICEAIDEFISQIISIPPKQLNIYNTRLDPIEDKSIEGRKIGIGLNEEDDNDEVFEDYENNMDNIDMSLDYQLIRTGKIFGGLVKDIKRKSPNFFSDFSDFFYGRFGQSLASTFFIFFAALTSALTFGAVMEIALNKEMAAIENILACAICGVIFGLFSGQPLNILTATGPTLAFETIIFSFSKTHNWDFLPFRFWVGLSIAIYLTIFIAFDLCTLVSLITRYTEEAFTILIGIVFILQALKDLISIGHSYPIQKNIHQIFESPCLCNLTGTTLIHKLKKVKNFDPSSCLAIGGQPHGLMCDYKPDIFLFSIILTSITVFIAYLLTALRHSNFFSSKIRQSLSDFNIVIAITVSTILSIVVGLDVPTLKIPETFKPTKDRSWIINPLIFDTYETYLYAGLLGICYSILIMLDQQITSAIVNKKDHLLRKGNGYHLDLIIVALLIVICATFGLPFYIANTVISLMHVESLKIYTTCNAPGEKAQLLGIKEQRLTSIIPHIIIGFSVSLTAIIKLVPLPVLIGVFLYMGIISLSSLQFVQRLRLFFIPIKHQPDLPWLRNMPMYRVHLFTVTQIVCLTGLFLVKYNKTTSMIFPLMIVLIIIIRLTILKVLFKERELLSLDGNPPKLKEILKPKTALDIVEERMKYSMIKKSGSKDSLKLSNSNTNLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3A9</accession>
    <name>A0A0N5C3A9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3A9"/>
    <dbReference type="STRING" id="174720.A0A0N5C3A9"/>
    <dbReference type="WBParaSite" id="SPAL_0001246300.1">
        <property type="protein sequence ID" value="SPAL_0001246300.1"/>
        <property type="gene ID" value="SPAL_0001246300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="62"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001246300.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="27230" checksum="E4F019F2CEEE3ACB" modified="2015-12-09" version="1">MKTLSQYEFKDDLKTFLSSFNDEKYEMKNIDDIFIRPLQTEWSSLEMIKILLKPGDIVEFERRILGVTVYSHFVIFLGIIQNDYIISHLAKEERIDNNKNLVNKKFSCHMKGNYSVQLSKIEDASFKHGKVRINNKQDKYLIPFNIKKIRKTSFNSLGLYPYNSLFDNCEHYVNRIRYGTHHSDQADKAYYKGFPLMSYITIFKYIQWKRKRNMFYSNKAINYKIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3G1</accession>
    <name>A0A0N5C3G1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SYF2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3G1"/>
    <dbReference type="WBParaSite" id="SPAL_0001250900.1">
        <property type="protein sequence ID" value="SPAL_0001250900.1"/>
        <property type="gene ID" value="SPAL_0001250900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001250900.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="20245" checksum="7EACDA060285F479" modified="2015-12-09" version="1">MTDSELAEFRERQKFHRKKWEERRTEEERVAKIQRDSKMRAERHKAMTEEERSEYNRKVREKKQKKREEVAAKLETLPKDSSEYKQLLEAERVKKEKKVEDHRQRKRKAKEMAASMALLREDDEAKLEHDRGDGREKRKRKKVETNLLPKKSREKERMSQPSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3M5</accession>
    <name>A0A0N5C3M5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <location>
            <begin position="68"/>
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        <location>
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        <location>
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        <location>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001326300.1"/>
        </source>
    </evidence>
    <sequence length="1238" mass="140647" checksum="FE49B58C2BC926DE" modified="2015-12-09" version="1">MFEFLVGFVLGALCIVTLVFSFIYIQFSQKNTPPKLTDQFHNLEMPEELKKFLNINDKANISTSRVESCFSISALLHFLFQEHKDTRFFRRWLHKRLQLEINDITSRNAAAHYIIHSVKIRDLDVGNKFPIIKNISVESIKMCDDDNSVESLSLLVDLVYTGNFYTSIFASTIFGDTFIGVKVTNLEGKAKIIMSRNPYPHWAFSFTNVPHLELAFETQLGGVAAQYCTPIIEKQFRNVIQKKQVWPNYKVRYRPFFPNPLMQPTTSPKTFSHVDIKGGLQVNIIQGSRLPIEILNGKKAIVYCAVFLDPKPFANFNANCNHVSTIMINFPRHDNKEPLGLTFTKHCDDFGGKKIKIENVAINSSAADAGFCQGDVILSVNNVVVSNSNHAVKLLNTKGDLSVLVERENDDLFRSDTPDLIQECFDEEIVDIEFDITRENKDNTTLTTISKEKDDKKEDTTIESDIPLVSNDNISLSDSLTKSSSDDTTIDKSSLQEESPKKGEDKNSEIIISQDIRKVGSEIRPMSMIEVSPIEKVTKWNSLDNLTCHPKDKIDSNIINNDGQNDEKSISNSSNISTSKNELDNLSIVTDECSEDADSLTELKTGKKRTKIVAKCAQMVNRFAVTKSKVNNIIKSRRDKNIENDNEKNDEHEEIQEGEEATEENMFNSEYENLYTKDPIVNSLTDMKLHKRPTSLEVPVVDGFKSKVKNVAKGIRTKRSTNDSILNEKETFSESFSQNNINVFAKNTSSVNLKSKVKWNDELYFTLEKNCTKYLNILVYAKYDETSENENKEDKNKNEKENNPKNKSSKDTVDEIDSGPILLGYTSIFVPQIIDDCNLTLSKCHCEVFDLRPTKNSNFQFTNLYNISHKPGFDKRLCFGDLKIFFRYLEKGLTDDMLHKNEIINEEKKNCNEIPIESSKKVLMVPENNGKQKQGLSEKVVKERYQHTFNTILAKKNESFICAVCKTKHWFAGLSKCSTCNVLVHTKGCSEKAYTNIECISVYQDSDFEELDNTMIVPNTTKDSTSLKLKVDSDGSDKVSVTSTPDRNSFLDRSSLRSIRKGKFSEKVSSGIKFLGKAYNRANKGETKEHIHNNVNLIKLDDVIHDYLILLDCPLSLRELLFEPNNAYNEAVIKNVKELGNLSFSDITDLDERKERNNEKITEVQKIISQLACHRKEKLLENSEISQNDQTKGKGSESPESRIVKQELIEMDLKFQALALVMIHYCEGLSACDATDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C686</accession>
    <name>A0A0N5C686_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C686"/>
    <dbReference type="STRING" id="174720.A0A0N5C686"/>
    <dbReference type="WBParaSite" id="SPAL_0001346000.1">
        <property type="protein sequence ID" value="SPAL_0001346000.1"/>
        <property type="gene ID" value="SPAL_0001346000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="91"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001346000.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="68039" checksum="FBE585FDD39C1DB5" modified="2015-12-09" version="1">MERRLSISSYNDTNIAEMLFPNTDSDISNLQNVVEDTTKFYSSSSEIFGNEDEIFKNGINTFLCNNQLCTILPNILIAIFLVFLILLTIFGNILVVLSVIVYKRMRTFTNILLTSLATSDLLVGLMVMPLSLIDLLHQHEWPFNALLCKIWATTDVLLCTASILNLCIISIDRYLAITYPLKYSRTRSKTMAFCLLSAVWGLSFIVCSPPWIIPSWKMNTSTDKENNSCSYPPSITYRIYSALGSFYIPLLVMLSVYFKIFRVASSREAMIREGLRTCRLSKRANIECKKLTKPSFTKSAHVMRSKNYDGYQENDRNKRTISSYGTGQLMKIELENSYNHISSGVYCSVRNNSTNSLQCPVVQKQSYKRNINAQDSSKNTKYMYRHRVEREYTSLTDLTVENKSLEKNVYDDNMGEYKKNKHNRSTLTMGIPNLDRDDKEVQTLAKKAQMAYTKLQPNNLLAKAQNHYNTYGPGRIIRGSKEKMVYLRERKALKTIGIVVMGFIICWMPFFILYLIEVLIDDLNKSTTFGILNVFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLLTFGCVSRQRRTMSVRKLHQQSTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6C7</accession>
    <name>A0A0N5C6C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMP_PDE_delta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6C7"/>
    <dbReference type="STRING" id="174720.A0A0N5C6C7"/>
    <dbReference type="WBParaSite" id="SPAL_0001349700.1">
        <property type="protein sequence ID" value="SPAL_0001349700.1"/>
        <property type="gene ID" value="SPAL_0001349700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000003">
        <property type="entry name" value="UNC119 homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF1">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="6">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001349700.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28195" checksum="5D05AB5FBD5B212E" modified="2015-12-09" version="1">MEKSTNTAIDSLGKSSTPKDSNYPISQTILEEELRMKDVITAEDVLSLQSITSDYLCDSQDNKYDIEFTKFKIRDMDTDQVLFEIAKPSDDEILQSSEEDDDDNDVRTDQNPEITKTVEDEVTSRTSSRFVRYQFSPNFLVLKRVGATIEFTVGDKPVKNFRMIERHYFKDKLLKSFDFDFGFCIPNSKNTCEHIYHFPKLSDQLIEEMIANPYETRSDSFYFVDNQLIMHNKADYAYDGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6I7</accession>
    <name>A0A0N5C6I7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the menorin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6I7"/>
    <dbReference type="STRING" id="174720.A0A0N5C6I7"/>
    <dbReference type="WBParaSite" id="SPAL_0001355300.1">
        <property type="protein sequence ID" value="SPAL_0001355300.1"/>
        <property type="gene ID" value="SPAL_0001355300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057489">
        <property type="entry name" value="Menorin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF6">
        <property type="entry name" value="CONSERVED PLASMA MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25161">
        <property type="entry name" value="Menorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Menorin-like" evidence="3">
        <location>
            <begin position="64"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Menorin C-terminal" evidence="4">
        <location>
            <begin position="315"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001355300.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="63346" checksum="421A9AE2BFB58A0D" modified="2015-12-09" version="1">MKVLLSLGWRYFQPSKLICIAVIFLVYGQYSVIKGVQHQNKRYINEHGMSFKDWIEEVHLSNRDLIDHSKMAEGEVLLFKTRKFRHRAIPIMKNTSYPDHQRFNDALTFKEWLKEMSPLGKALKVTLKNTEVVKPVLQHLYATNHLIKSPIILHANVFKSQRSVEKPVDSYTLLENAHKFVPNAAISLGWTKEQEDNNDKSVVENINHLDWGHTFKILSYLSSVNYQPIILTIKLSDALESSEQLLFLLGQNRPFYVIIYSKPDDTINNLNVFQNFLSFARKNGNVIFDLSPEHRDLVKNLNDKPLQMSINKNDWRIINHPSPYGINSQVVPSDRGIAFIGETKSFAILNRTNYDNHYPNKQKITGKIHFLPKKFITTNDYDTSGMEIVLFDNPHKTPGKISLTDSSKLRNSVTIFIGVDGDVSISNSPKSKKIYDGSAVGKVPKMRCYGFEITDRGWRVDLAVWTENCHANKNKRSHKNNDNMYETFIQLETPLSKSRKLRNVIIGKRGGEDVDFILEKASYNGASSFTANVFTYVSMILIFLLQRFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Z3</accession>
    <name>A0A0N5C6Z3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6Z3"/>
    <dbReference type="STRING" id="174720.A0A0N5C6Z3"/>
    <dbReference type="WBParaSite" id="SPAL_0001370800.1">
        <property type="protein sequence ID" value="SPAL_0001370800.1"/>
        <property type="gene ID" value="SPAL_0001370800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF877">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="71"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001370800.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39136" checksum="A29933A27E079647" modified="2015-12-09" version="1">MGLKVRNETDEIDTEIVIETPMENLDLYEGDTILTEKQVDEMVDELVKQADEKKIDVSNIEDKSRKKRGKRSIYSSKNNMWTFPIPYYVETGVDATLVTTALNFIESETCVRFTKSATPITGKPGLRRIYTDAPQEISIGSGCGQKGILQHETAHALGVYHEQSRPDRYLYVSIKTENIIAGKESNFAGSIPGFAFSKNGNQTIVALDRKFDKTMGQRNMLSFNDVKLINYKYCNSTCPSTSISCRNGGYENPNSCGVCRCPLGFYGTNCQNYVGSKSTLCGNQFLTANTTLQTLNVTGAIECYYYISTPMYQVRLNVISTNLVNNDPCYTGKGLEIKYQNDRSALIHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C776</accession>
    <name>A0A0N5C776_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G patch domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Coiled-coil domain-containing protein 75</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPATCH11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C776"/>
    <dbReference type="STRING" id="174720.A0A0N5C776"/>
    <dbReference type="WBParaSite" id="SPAL_0001379000.1">
        <property type="protein sequence ID" value="SPAL_0001379000.1"/>
        <property type="gene ID" value="SPAL_0001379000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4187" evidence="7">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001379000.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30607" checksum="823A54F547E16896" modified="2015-12-09" version="1">MSDEDDDYMSEKVLNGFTENIEVKMIRNRERDRLLRIAKRTDMARQKQLEQVSLPKKQEMIRKEIESQPLPDDNIGLKLLKKMGYNPEEEEEGKGKLGKPIKVESKNDTLGLGFAEEEKKKAKELFEEQVRKTHEQVKKIDSLVDDFRKRKRDVKLLGLCISDVRKCQKVCYEMDQRINMDKPVNDYFWPRSIMKVEDDDESFRLERLTEDEIFDCLENIINYLRDQYFYCIYCGCTFEDEDDMKSQCPGVTREEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7S7</accession>
    <name>A0A0N5C7S7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7S7"/>
    <dbReference type="STRING" id="174720.A0A0N5C7S7"/>
    <dbReference type="WBParaSite" id="SPAL_0001398800.1">
        <property type="protein sequence ID" value="SPAL_0001398800.1"/>
        <property type="gene ID" value="SPAL_0001398800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="281"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001398800.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="57695" checksum="E56CBC15149EFE05" modified="2015-12-09" version="1">MYLAKLTNTLRFNRQCSTIAHTLKVKQQINDAKAAAALGGGLKRIEAQHKKGKLTARERINVLCDPNSFREYDMLMEHDCTNFGMDKQKFAGDSVVTGRGTIAGRPVFIFSQDFTVFGGSLSAVHAKKICKIMDQAVKVGAPVIGLNDSGGARIQEGVDSLAGYADIFYRNVQSSGVIPQISLVLGPCAGGAVYSPALTDFTFMVRDSYLFITGPEVVKAVTNESVTQEELGGTKTHTVTSGVAHGAFDNDIDALLNMRALFNYLPLSCNEPPPTRMCEDPWDRDVPNLDTVIPLESTAAYNMKDVITSIVDEGEFFEIHADYAKNIVVGFGRMNGRTVGIVGNNPKFAAGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAYAEATVPKITIITRKAFGGAYDVMSSKHLQADINYAWPTAEVAVMGAKGAVQILYRNDKENWSKHEEDYIDKFSNPFPAAKRGFIDDIIEPSTTRRRICEDLKLLENKVVVKPKKRHANIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Y9</accession>
    <name>A0A0N5C7Y9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Y9"/>
    <dbReference type="WBParaSite" id="SPAL_0001404900.2">
        <property type="protein sequence ID" value="SPAL_0001404900.2"/>
        <property type="gene ID" value="SPAL_0001404900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001404900.2"/>
        </source>
    </evidence>
    <sequence length="569" mass="65945" checksum="D4C3474349AC5C57" modified="2015-12-09" version="1">MLESRISTETAPSPLTLNAAADRSGYVTDASSTNWQFNNSFSPRSIVSVNGGTIKDSPSILKIRTNNVEKRYNRSNSSVTNSVLTTTETEPIVREFTETYSRIKVRNDHESSNVRQGNERIENIVQKPVHITKESLSPPTVRVPLPLSSSATRRHNSSTSHSPNYSTPEKLTTTIIHLKDDKPKGIIKPVVTKPRVTETIKRIEETRRTEEVERRVQRREKKHRSHRYHHDDHYMTENHYSGDNLKERRKVLSAEEENEIREEAKQLKALHRSSSTGDKKITNYYYKKRRYTSEELNDAVKSHRSSSMNRNGLLPIGYYPGYESYNRSSTTRRDYENGHNDGQYHYMNGRMMNQQGRYDSSLSDSLRRGDVRYNPNGEIRESYTYDNRGHRRNSNAGYGMHKSYSTRDVFRDSNGGYYGSYYRNPPTQPFVEFPPTLPRRHGEPPIPPPHRSASQMGMESQYRPISKSHSYADWSDQRNQNGNHAYGRRHDEEMSKLENEFRDSLLVPLNNGNGNINDYEHRVEQIPGGYEEYSRSVKGNSGRRLNRDGVPTDFREQSHSYSFHREQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C884</accession>
    <name>A0A0N5C884_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C884"/>
    <dbReference type="WBParaSite" id="SPAL_0001414000.1">
        <property type="protein sequence ID" value="SPAL_0001414000.1"/>
        <property type="gene ID" value="SPAL_0001414000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001414000.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28558" checksum="E7FD568935D1EBA1" modified="2015-12-09" version="1">MPFSSLALRNSACGDDVYSKVVNLPVACFPDFSKQVRSLVQEYYNGECKLEANLLFKGSGSISKGNLSLGYLSSGSKNLSEDNSSSDIKTDDISDAYSCLNCKIKTKKVKDFISTASEGKGITKKSENIKDMRSIAEHEHMPGVKHRQMNDKKLHSYEELNETTSDTVCKTSPKVFNKLRIYAHPNFMNSTNEEKITTETTSKGSGSKCLSSSNKSSLPVFDDIKLVFYQNTGINSLNSRKSLTPISFDTHGSPRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Q4</accession>
    <name>A0A0N5C8Q4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Q4"/>
    <dbReference type="WBParaSite" id="SPAL_0001429400.1">
        <property type="protein sequence ID" value="SPAL_0001429400.1"/>
        <property type="gene ID" value="SPAL_0001429400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895653" evidence="1">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001429400.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="36396" checksum="DEE42840CBD98BAE" modified="2015-12-09" version="1">MRISIKKIIFLLLFHLELQLGLCYINSTSTKELFIDKEKVVNSTFFALLEYRLSTCIISKNFSTMLTSIFCYLFMEKKFKLKYNHLADFNWKFSKCIRQIKYKSLRELINDLNYHNDNEFSKNWILLLIVRNPIERFISGYVDKCTQRIRLKKRTKMCLYCVSNIECFINRLYKKINSSIKIKRATYNGVKKHFFPQIMQCDYYKHKNKFKILKYDRKNLNNFYSEFEDILASRNISKNHIKFMDKELKNFRVHHATSNKTKTNEFTLRLYKNKRLINKLINIYNRDFKEFNFPYPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Y6</accession>
    <name>A0A0N5C8Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin C</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Y6"/>
    <dbReference type="STRING" id="174720.A0A0N5C8Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001436900.1">
        <property type="protein sequence ID" value="SPAL_0001436900.1"/>
        <property type="gene ID" value="SPAL_0001436900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001436900.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18650" checksum="573B93C12B34D362" modified="2015-12-09" version="1">MFKSDDVIAEALDQLTAEQIEQFKKYFNMFDKENKGYIRATQVGQILRTMGQAFEERDLKQLIKQFDADGSGEIEFEEFAAMVANFVVSGDDNAGLEEELREAFRLYDKEGNGYINVSDLREILRALDDNITEEELDEMITEIDSDGSGTVDFDEFMEMMSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA77</accession>
    <name>A0A0N5CA77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA77"/>
    <dbReference type="WBParaSite" id="SPAL_0001480100.1">
        <property type="protein sequence ID" value="SPAL_0001480100.1"/>
        <property type="gene ID" value="SPAL_0001480100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001480100.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15734" checksum="6DDBC572495EF803" modified="2015-12-09" version="1">MIVRDLYYIFPTCLILAFFIDYTNSQALNDPITQYIEGRLGNRRIFWCPSGYGYLAYCPQPTDWDNYNWCCTWPYMGSWKPSCCPFAIPTGAVVAIIIAAIVLLAVLIGMSCWCCYCCPLYKQLYEYEDDPSYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAN0</accession>
    <name>A0A0N5CAN0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAN0"/>
    <dbReference type="WBParaSite" id="SPAL_0001495000.1">
        <property type="protein sequence ID" value="SPAL_0001495000.1"/>
        <property type="gene ID" value="SPAL_0001495000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001495000.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41442" checksum="27133B28FF129CA7" modified="2015-12-09" version="1">MVETITFKKVPPYPIMPNIVKLYISKSLDSEKIYNQLFFLSYSSCLDFHKLYTSNKHIGINFFSTQRKSKVILSNSLKRPTNVYLKKNVIHNEKQLAFYVGLALGLIPEVIRSDRNEHIKIHWKNILKSYKKYYKKEPYNEQYLTNTGFDFSSVMIYNPYYGSKNGKQTFVSKLYPYYEKVISIFKHFSYNDIKRINYMYCGNICRKENQCLHGGYFIKTCDGCRCPLGFIGNKCENIDSEFDKCSPKNNFLAYSFKKNLLIKNISRFCMYSIKSKKGRKVRITILNTKLSKTNSCDKGIGIEIKYGKDKAAKGLLLCNNYRNIKIPAISSEIYIIFSDYYPNNLLKLSYNEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAX4</accession>
    <name>A0A0N5CAX4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
            <ecNumber evidence="5">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAX4"/>
    <dbReference type="STRING" id="174720.A0A0N5CAX4"/>
    <dbReference type="WBParaSite" id="SPAL_0001504000.1">
        <property type="protein sequence ID" value="SPAL_0001504000.1"/>
        <property type="gene ID" value="SPAL_0001504000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001504000.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41470" checksum="3A20FE1C5D819254" modified="2015-12-09" version="1">MIVRQSHNIPSYPVELPLNDNSTLENLIISLSEQLFTEWKLYKKKISYFTNGITNKIVGVEATDYTGSHPSHLIFRIFGKNTENFIDRDTELHNFQMLNSVGLAGNVYAKFRNGIIVDYLDGETISVDGVRKNDMSKKIAVALGNLHKLNIGDENQTPMIFDKLKDYFLIMKTEFDNKNYQTNFDNYFKNISIQDDYNVLSEYIKNDPCMLVFCHNDLLLNNILYDEEKDSIHFIDYEYAGVNYQLFDIGNHFNEWAGIENIDVNLLPTDSQKRHFIRSYLQTLSSHQNLDKEIDKIMRQISLYEAASHYFWAIWAVVQASNSLIDFDYISYAIERYSFFKTSLSIYKKNINIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCE3</accession>
    <name>A0A0N5CCE3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCE3"/>
    <dbReference type="WBParaSite" id="SPAL_0001555300.1">
        <property type="protein sequence ID" value="SPAL_0001555300.1"/>
        <property type="gene ID" value="SPAL_0001555300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001555300.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18817" checksum="3AF0ABD8A670C884" modified="2015-12-09" version="1">KITSESKQEFFEANDNVALKNLLTNAGKCVHLDFFNLDNKIGYCYGFIEDGTFQYRKMLGKSNSIELNFKLKGYLNLLQMVHMKGFNNTIITIYDVILFSALKDPDSIQSLTQPNRALFSSLASGKHIKTILIDQNCSYELVGNIRNAIKHFTVSNTKNYEISGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCE5</accession>
    <name>A0A0N5CCE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCE5"/>
    <dbReference type="STRING" id="174720.A0A0N5CCE5"/>
    <dbReference type="WBParaSite" id="SPAL_0001555500.1">
        <property type="protein sequence ID" value="SPAL_0001555500.1"/>
        <property type="gene ID" value="SPAL_0001555500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="91"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001555500.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38583" checksum="7FCC81C54150700F" modified="2015-12-09" version="1">MFAYESLESHHLTVSTDNSKSQLLAQELFDEYHKKLSHICYSKMKDYVIEHLHELKLSHYMVLEVLEKLLILMKECPICNQNNPLKRKKKLRTTPTTVLKILYLDFALLENHYVLVMIDGFSKYLWTVVTESQSTNIVITALHSIQNQLDCPIITIRADNFKSFTSPQLIQEFPEIKFESTIPNEHTSNGVAERVIRTLRALLKKDESTFRGRNSFQRRVAVVTRNYNRTKHSSTGERPRDLIFAFSTHGISRDPEDIKLKNLKLETLQYVNNPVAYRIYKQGKPETAVGILQSVNENDDTVMIKSKENSMIKRPVLKIRPLENFKGGRSKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD76</accession>
    <name>A0A0N5CD76_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CaMBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD76"/>
    <dbReference type="STRING" id="174720.A0A0N5CD76"/>
    <dbReference type="WBParaSite" id="SPAL_0001582200.1">
        <property type="protein sequence ID" value="SPAL_0001582200.1"/>
        <property type="gene ID" value="SPAL_0001582200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="10">
        <location>
            <begin position="491"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001582200.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="74436" checksum="81C3250E102BB1AD" modified="2015-12-09" version="1">MEKMIILQQLNYDQNSGDTYSTITPIQATNEVTTTNNSKNALTTIQGRNGRRHSSMHEVSADFLRLHGSRQQFRNLLSARKKLGQLPPAYTQIDCSHESLDSSIGNKYNILNQPFPQGPMITVENTGTNTLLKMNPFSSSTNSVVNLESAVSSVEKNVYIENGGINCGTSAKYFQRNNSRYGVQVDKSHVQMLYKLRSDKLNTGVQVTDRCLLLAMIGIFFMIVETEMCGQQIFNITKNHPASYLCRTLVLLSTVCLLFEIVHFHINDIYIDLLDCGADDWRVVVNTRRIFKFVIEFIVCAICPYPGTGNIYWTFIEPQRYEDHKKFVKEVPVDVILSIMMLSRIYLIARFMVMHSKLFQDASTRTLAALNRIQVNFSFVMKTLLDQKPLIFLSIFTFCFWIIMAWIFAQVERYGRDEPSEILYSNSLWFIAITSMLNGYGDIVPKTNLGRVIAIFAGICGAIISSILIAVISRKILLSQGQRNVNIFMNDSRLTQEHKNTAARVLQHTWHIYKCLRSDGTDSQLRDHQRRFLNAIHSFRKVKNKMRLFGENCATSMQQMNRLMTEMHTNMQKVISAQDEMKTQMDVMQRTMRNHFSNCQQRQKAANNGMGNGAGNQNLSNNHSLTVGSNSPPVQQRVMFAECLEETYSDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEI9</accession>
    <name>A0A0N5CEI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRRcap domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEI9"/>
    <dbReference type="STRING" id="174720.A0A0N5CEI9"/>
    <dbReference type="WBParaSite" id="SPAL_0001627700.1">
        <property type="protein sequence ID" value="SPAL_0001627700.1"/>
        <property type="gene ID" value="SPAL_0001627700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000131">
        <property type="entry name" value="acidic leucine-rich nuclear phosphoprotein 32-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001627700.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24914" checksum="84DD679D4D9D3B04" modified="2015-12-09" version="1">MPNITEETIEDRIKKELNGGDKKDLVNLYLDNCKIESFEPLAEGFDSLESISLINTSLSSLEGFPTLANLKVIDLSANNLTGSLKHLTKNMEIAHINLCSNKIEKLEELEPLKELDNLKSLDTFDNPISFLENYREAIFKMLPQLTYLDGADKSGTEMEMTMHSGAEDDGEEGAEDDEENDRGLSILNDPEACEDDDSEDFVPPSEEEVSSRGVKRKHPGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEP7</accession>
    <name>A0A0N5CEP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEP7"/>
    <dbReference type="STRING" id="174720.A0A0N5CEP7"/>
    <dbReference type="WBParaSite" id="SPAL_0001633400.1">
        <property type="protein sequence ID" value="SPAL_0001633400.1"/>
        <property type="gene ID" value="SPAL_0001633400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004937">
        <property type="term" value="F:alpha1-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000469">
        <property type="entry name" value="SERotonin/octopamine receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001633400.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="69420" checksum="BC87709B36B51D4D" modified="2015-12-09" version="1">MNFSNTTSTTFKVDMEIENANFHGNAVFPELSYYQSLRTIIPNWVLLILSLPVTVIIFLTIFGNLLVLCFKARVGRTNTTLLVWNLGLTDFLVGVIVLPLGAIHFITQEWKLGRILCRLWVGADVTFCTCSVVTICVISVDRYLAVTRPLKYKTVVTKKKVICVMIIIWTFSSCILLSTVRWEQPIEMDNTLCFAGNEIRYLAHSVVFAFFLPASVTLTLYWRIYRLARQRQKALDRGFLMILGQNMNFLTNTITQHTTLRVHIGRKNGMVEHQRRVLRTHERIAKTLGVVSCSFLFCWLPFFMLYLTNYQCSGCIPTIFIEGASWLGYCNSMLNPIIYSFTVKQFKKSALQAILPFWQILYQLLPSIVRPPPEHVKTKISRNVHIKSKNKAPIPRKDNLISHNKEKNVHQKNPIIPYPYKGKIEYEQQTSCMNNSHNITTNITINNSTTKSQQEQINKINCTEIPSIISNNNVNDEYELRGGKHYDPDSITLNSDDEILTSGIMFREGSSRRRSITISDFSNIETLSRIGSDENLPVNTNFLFASGLSKNSKSLNLHGNRTVIRLDYTPKGKKKRKNKCEIEEIKIIVPSEDNNISHNKDEPKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF24</accession>
    <name>A0A0N5CF24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-processing factor 39</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF24"/>
    <dbReference type="STRING" id="174720.A0A0N5CF24"/>
    <dbReference type="WBParaSite" id="SPAL_0001646200.1">
        <property type="protein sequence ID" value="SPAL_0001646200.1"/>
        <property type="gene ID" value="SPAL_0001646200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001646200.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="81435" checksum="29F0BE3FEFE4756E" modified="2015-12-09" version="1">MATSREQSPDEDEKSVSVESPQTSIKRESRKESKESPSPKKSRKVKDHSKDDKKNKRSSRRSKSRESSKREKSKHSSKYSSKKSNDSNDRDIKIHYSLKPIWDKLEENPKNFDLWVELITKSAENNIDQSMELIFKRFLEHFPYCYGYWIQYATYINNRDGPKECLYIYQKAVKEFPICVDLWMSYLQVAMEHFMMQPDGITDILKIINKALEECGMDFNSDNLWISVIDWEVSICDLKSAFKHFEMILGITTDKMELHQRRFEEFLRGYSPDLYLPDSQLDSITKRVLKKMGKNDIKDILIKINNGNETTNVLCDEAHMLYVKYILQEQEDKIKKTTRDYEGRKDFEHQIVRRYFHVAPLENKQFSLWFKYLDWEINNRDEKKIKCLFERCLVACCLYEEYWMKYARYLDKNVSKTQAKAVLTRAHKIHIPSSSKIALLLSLMEERNNNFNEAVDILDNFDLKYPGYASVRLRMVSLLNRKLHYQNRPDETRVIEKMERLINERRTSKTLRNFYIKKLARFQAFQCNNLAKADKLLREAIKNDPENNELYAQLIDIYYCCSKTNIRHVCDAFDLAIKSTSLSDHHRLQYAKRKMEYMEEFCMEPSKIQTAWDDYNKLVEESGCTISYVNNQKQRTMPVPYKPMSFAEIQRQTSSTNQMPMMVNDGMMYGMMPSNTYMGNQQNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF33</accession>
    <name>A0A0N5CF33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYTOSOL_AP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF33"/>
    <dbReference type="STRING" id="174720.A0A0N5CF33"/>
    <dbReference type="WBParaSite" id="SPAL_0001647100.1">
        <property type="protein sequence ID" value="SPAL_0001647100.1"/>
        <property type="gene ID" value="SPAL_0001647100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001647100.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="57844" checksum="D4B2DF998A500185" modified="2015-12-09" version="1">MAFPLPTLVNVTNTLKGNFDGIVIVSHSIELVRKHSQLCKIYENLVEYSAENKSINTASAHFILLPFDSFPIRRLIYSNVGSIDEDFDDVRKYKTAAINGIDMAISSGMKNVVLITLSDGTFQQANLVSAFGALHCTYVPLTVRERNFKHQISLESLNVFVDEKENSNLDKILKAFLISLTVCRDVGDSDPIRMTPLKVGKYMQDLFDEKSSVKIKNITDLNIIERDYPLMFAVNRSANDVPEHRPCLIKLEYQSSPDNEDVETIMLVGKGVTIDTGGINLKIGTAMNGMSRDKYGSAVVAGFFAALNILKPKNIRVIANMPMVRNSIGSNGYTCDEIIKSRSGKYIRIMNTDAEGRISMLDSLTELLEISAKYKNPHLYTLATLTGHEVLAHGEYAAMMDNGPALKHGTSNEILKTGEIYGQPLVIDRLQPEDFQFNFPECKEADLRQGNTLASVVTLRGHQAPGAFLIQGSGLMNHQNKSERPVKFTHIDMGSCMGDFPNVSYPNPLVTLIAHYILPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGJ0</accession>
    <name>A0A0N5CGJ0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA topoisomerase</fullName>
            <ecNumber evidence="3 11">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGJ0"/>
    <dbReference type="STRING" id="174720.A0A0N5CGJ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001696600.1">
        <property type="protein sequence ID" value="SPAL_0001696600.1"/>
        <property type="gene ID" value="SPAL_0001696600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="14">
        <location>
            <begin position="172"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="13">
        <location>
            <begin position="655"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001696600.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79455" checksum="51B16F9A24FFA1C6" modified="2015-12-09" version="1">MSKFINGAAKVLFVAEKNEAAKSIAKVLSQGNYSRREGLSKFNKIYEFEGNVLGRKSLISTTSVSGHMLTLDFEPKYKKWGYVVASQLFEAPVRKYIIDDLKDVESSLKNYSSKNGTLVIWTDCDREGENIGGEIANTCSKFNKDIDIYRARFSEITPHAIKNALENLTKLDQNVINAVDCRIELDLRIGAAFTRLQTIYLKKRFPVMLRNSNSDNNNNNLISYGSCQFPTLGFVVDRYVAVKNFIPERFWKLRTFHMKDNIKTEFTWERGRLFSQTDVESYLTTCKDNISSAKIVSVKRSPKSKKRPVPMDTICLEKLAIRVLKMSAKKAMDLAEKLYSKGYISYPRTETTIFPEKLDLSTLINKQVANPSWGQFADEILNTGGPKPKNGKKSDKAHPPIYPLVHVKEDELQDDEMFSVYELIVRHFLACCSRDAKGQETTITMTIGEEVFKASGLHIEDKGYLEVYPYDKWASKTIPKYIKGEEVSENLEIDIHEGTTTPPALLNESDLIGLMDKYGIGTDATHAEHIETIQKRKYCSLDKDRRFVPSAIGLALVESYNLLGYQLSKPNLRADLEKDLLSICNGEKTKEDVLSHQLGNYKRIFENVEGQIEVFGDYFENEVKNNNNLWEKNNEGTSQNPLQDPDLKLSESVKCHCKKPSAIYTVKKGGANNGKLFYACATSLSHDKRCNFFQWCEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGL0</accession>
    <name>A0A0N5CGL0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGL0"/>
    <dbReference type="STRING" id="174720.A0A0N5CGL0"/>
    <dbReference type="WBParaSite" id="SPAL_0001698600.1">
        <property type="protein sequence ID" value="SPAL_0001698600.1"/>
        <property type="gene ID" value="SPAL_0001698600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001698600.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10347" checksum="356FE27D1741D0F4" modified="2015-12-09" version="1">MTKGTQAFGKRHNKTHTLCRRCGKSSYHIQKHTCASCGYPSSRKRTYNWSVKSIRRRTTGTGRMRHLKKVHARFANGFRSGAPQKAAPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1Y4</accession>
    <name>A0A0N5B1Y4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B1Y4"/>
    <dbReference type="WBParaSite" id="SPAL_0000008600.1">
        <property type="protein sequence ID" value="SPAL_0000008600.1"/>
        <property type="gene ID" value="SPAL_0000008600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF310">
        <property type="entry name" value="PROTEIN 60A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000008600.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11037" checksum="BC244E2154E2A7A4" modified="2015-12-09" version="1">XNGRGRKLCQKTDLYVDFKELNWDDWILAPEGYNAYQCRGICSNPLPSKLNTTNHAIIQSLINTLNPLSVPAPCCIPTRLAPLSILFVDFNKHVVINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2B9</accession>
    <name>A0A0N5B2B9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2B9"/>
    <dbReference type="WBParaSite" id="SPAL_0000022600.1">
        <property type="protein sequence ID" value="SPAL_0000022600.1"/>
        <property type="gene ID" value="SPAL_0000022600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000022600.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36336" checksum="32F1CD1F37BD1710" modified="2015-12-09" version="1">MISDETITLLCYFSICSFGLIINAFCLYKITTLREFRHCFGYICTVQLISNTITLTIFLFWSCPSLLFLEESNIYEIFNHIFGDFGILAWNLTMYSHIACCVNRFIAMYYPTKYSGIFDKRMCRIIILSIWILSMCHVVPYIFFGCSYKFSNTNLTWIFEFNKCTNILTSIDFYLSLTNVCFTLFLDSLIFIKLGIQGKKSSELHGTNAVSVINVKSTDVQSSNKKLTVKKSSKTKSVYSNRVRFFLQSFIQNILIAIELICFHIICYRVQGKIWAMVFSSCAWALCHTLDGLVLCIFNKEIRNSLLRVCSHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5A0</accession>
    <name>A0A0N5B5A0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5A0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5A0"/>
    <dbReference type="WBParaSite" id="SPAL_0000124500.2">
        <property type="protein sequence ID" value="SPAL_0000124500.2"/>
        <property type="gene ID" value="SPAL_0000124500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF130">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000124500.2"/>
        </source>
    </evidence>
    <sequence length="517" mass="61119" checksum="F724E4E7255E470B" modified="2015-12-09" version="1">MYLNNILILIFILSIYFLFKKFFKWYNERQRILKYLKKIPGENGLPILGSILDFQGPPSVILDKTYEFIQKMNKYNYPVMKIWIGPYVLVYLPSPEVQKQILESTKEITKGSTYDLLREWLLDGLLTSSGDKWKYRRRIITPNFHFKMLCEYHVIFNEESKVLVKILEKFKNTGKEVKVLGYMKRCLFDMIMSRFSLKNLYNKKLMLGTAFGHNLGCQFDSENSYLRAVEGFNEMSYLASVNIFYKNKFLLYLSGKGFKKDRYLKILESFADKLIKLKHKEYLKEKEKGGEIKHKTFISMLLELYENNEISMEGIKEEVNTIIIGGFDTSSTTMAWLLWCLATHPDIQEKVYQEIFDIFGENERVVTHEDIVRMPYFEMVFKEVLRRFSIVSIMTRRLQNDIRIGEYTIPKGIDVAIGPFLSHMNDKVFPDPYKFDPDRFLPENSANRSAYDFIPFSAGPRNCIGQKYAAHNVKILSIWILRRYRVRANYPFEYLKMVPQIVTNSDKDYPIIFDSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Z0</accession>
    <name>A0A0N5B5Z0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Z0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Z0"/>
    <dbReference type="WBParaSite" id="SPAL_0000148100.1">
        <property type="protein sequence ID" value="SPAL_0000148100.1"/>
        <property type="gene ID" value="SPAL_0000148100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000148100.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30321" checksum="3F79911B629992DC" modified="2015-12-09" version="1">MPPRTSEYTFDSKESKCPYKILGVAKDAAEGDIKKAYRKLALQWHPDKNPDNNEVAEKKFKEIAQAYEILSDTKKRADYDKSKTRPTFSRHSFGGHHAPSARANFASGRHRNSTGSFQHQNPFFTHTSFRSPFDIFNEFFGDPFKFPDHHSAFTHHSPFHSFFDSKDPFTAFHKQSMPHKFFKHARSFDDEKDENDSGYSSVIRFSSSNEPGKNAKKITTSTRIVDGKRVTTKKEEDNGVETIEITEDGILKSKLINGKEVTIGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6C7</accession>
    <name>A0A0N5B6C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6C7"/>
    <dbReference type="STRING" id="174720.A0A0N5B6C7"/>
    <dbReference type="WBParaSite" id="SPAL_0000161650.1">
        <property type="protein sequence ID" value="SPAL_0000161650.1"/>
        <property type="gene ID" value="SPAL_0000161650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000161650.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9427" checksum="525A9530F28149F5" modified="2015-12-09" version="1">MSDEEIQSINDSAIKYSDSQPISSDGNNRSTSRSLSKFFKSIFYSNFPLNKSSSNVEDIRNKYGDEGNNTENSSSMTSLKVDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Y7</accession>
    <name>A0A0N5B6Y7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0000182400.1">
        <property type="protein sequence ID" value="SPAL_0000182400.1"/>
        <property type="gene ID" value="SPAL_0000182400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000182400.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22506" checksum="9D2E7A7DC33194AD" modified="2015-12-09" version="1">MGCCIILAIIDLEVYNFGLYIVLLCIVGTMIACALCIANPNACPNPQWYTNFCLLMEEMYPVPNDIDTESPKMSGLRKQMLSHYGGSMATNVNSNTGFNSGEESKTGNRFENKGTVAMLAPAVHIMHQVWRGMAWVTDAVDEEEDNRTHSYCTMEHGTSFSSRTNSDVGLPTKKLSTIVESSGGSFVIEQDETSDCTSRYDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7E0</accession>
    <name>A0A0N5B7E0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7E0"/>
    <dbReference type="STRING" id="174720.A0A0N5B7E0"/>
    <dbReference type="WBParaSite" id="SPAL_0000196600.1">
        <property type="protein sequence ID" value="SPAL_0000196600.1"/>
        <property type="gene ID" value="SPAL_0000196600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="258"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000196600.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57654" checksum="0C649BC491363FC3" modified="2015-12-09" version="1">MLSPAMLKSSIKRSSIGDKNHFLNNSKNAQVQSDNGVGLGPLGKRLSVMFDDQKPLLLLPSGSGNPNNNSRKSSITERKISDEVDAFIVAKNTRRRSMPVIKTKTDMSASLLFSNIPKSDSCDDSEPEKKHDIILVKTEANNISAMMTGRYENPQYPTSLQGSSKPLRKLTKSDSLDYIGNGSKLYPTSFKQLRRESLISMEAARNRRDSELQFPIEIKPHKYTDDPTLAWEMLKDKRPVRNVRQMKLDTPIRPDALRFVCIGCTHGTHLNPKKIPPGDVLIVCGDFTSCGLPREVKSFDDNLAQLKHPFKIVVAGNHECTFDENFMKINSSSITDPKEGALKHALNAALTAAKITNPKILLTHCMYLQDSLLELCGIKIYGSPWQPKNDKWAFNLNRGQPLLDKWNQIPSGIDILITHTAPLGHGDLMANGVRGGCVELLNSVVKRIRPAYHVFGHIHEGYGCTSDGYTKFINCSHLNDSSNVRNNPVIFDIAVPPEVKLNNVRNAKKIMKKFNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M2</accession>
    <name>A0A0N5B7M2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1115 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7M2"/>
    <dbReference type="WBParaSite" id="SPAL_0000204700.1">
        <property type="protein sequence ID" value="SPAL_0000204700.1"/>
        <property type="gene ID" value="SPAL_0000204700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000204700.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20936" checksum="79E5451E28B3C7E5" modified="2015-12-09" version="1">MAKFKIEENVMSLFNEQNKRNSLIGINKESTPERNACQDFFNKTEKNNQTSSLGQKNGGTKVIAKLSPKISPKCSPKTPLIKASSVSPNKGKRFKCMLTMTEGPISDVHNHIKRALWQRFGINRYSCNFEECTYGGYNLKAIINHQYIIHNIPDTSKANIRDIFEQHKEFYLSFKKQFIIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7S1</accession>
    <name>A0A0N5B7S1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7S1"/>
    <dbReference type="WBParaSite" id="SPAL_0000209600.1">
        <property type="protein sequence ID" value="SPAL_0000209600.1"/>
        <property type="gene ID" value="SPAL_0000209600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000209600.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27171" checksum="6FC942CE185DA3DE" modified="2015-12-09" version="1">YLTIFMSNVEEGFENNFFKTDFSETISYGIPYDYGSDMHYRTNAFSKNGEPTMLPTDPLYKKTIGMDAGLTFLDAKILNEHHCQHKCIRPIKCYNGGYRNPNDCFSCKCIAGFEGSDCSKMPDDSMECGDAVRKVSKNKTVRLYSRGKGSCIYHIKSETNSTLKITLTEIVYFPGFKSTCVLENSLEIKYYNDKSLTGALFCLSEKNRTIVSQGDHVIVHHRSTQGTNFMLMQFENVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8B7</accession>
    <name>A0A0N5B8B7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8B7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8B7"/>
    <dbReference type="WBParaSite" id="SPAL_0000229000.1">
        <property type="protein sequence ID" value="SPAL_0000229000.1"/>
        <property type="gene ID" value="SPAL_0000229000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="134"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="327"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000229000.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="71783" checksum="2034BF3F7AE85875" modified="2015-12-09" version="1">MRIPFIARTTTAYLDLAHSLSIKSTIFGRRSLSSSSVLYGRMPAPDPDDPEAMAIHKLYRPERVTPTKRGYDILKDPAINKGMAFTLYERQYLGMHGLLPPAFMTEEQQAYRIMIKLRQTKDNLEKYIQLSSLLDRNEKLFFRVLCDNIKELMPIVYTPTVGQACQEFGFIYRNPRGVYITPNDNSISKIHQILCNWPHDDVRAIVVTDGERILGLGDLGAYGMGIPIGKLTLYTALAGIKPSQCLPVLIDVGTDNQKLLNDPFYIGLRHKRIRGKEYDTLLDNFMNACVKKYGQDVLIQFEDFGNQNAYRLLDRYKDNYTVFNDDIQGTAAVVVAGLLGTTRVTKKKLSEQRFVFLGAGGAATGVAEMCVQQMLTEGLSHDEACDRIYLMDIDGLITKNRMNNLGERHIPFAKDLPDTKSLLDVINTVQPNGIIGASTVKGAFTPEIIKRMAEINPNPIIFALSNPTSKAECTAEDAFRLTKGKVLFASGSPFPNLEYNGKIYKPGQGNNAYIFPSIGLAVCLFKIKHIKSKYFLIAARRVAASVTQKNLDEGRIYPRLKEIREISVKIAVEIAEEAYKDGLATLYPKPKDMELYIRAQVYDVEYDELINKTYVWPEKDCKHGFPVPVMRRDSMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8J9</accession>
    <name>A0A0N5B8J9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1749 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8J9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8J9"/>
    <dbReference type="WBParaSite" id="SPAL_0000237200.1">
        <property type="protein sequence ID" value="SPAL_0000237200.1"/>
        <property type="gene ID" value="SPAL_0000237200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000237200.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31093" checksum="F7BA1A5B4BEDB836" modified="2015-12-09" version="1">MSQELEFLGYSFNDSGILVDKDNKRFVFTTQKEYEILGEAITEYVYEILEKKFNFQKLYFDEDNTEESSFIYASQNYKDCSEIIIFINGSGVVRAGQWARSIIINENIDMGTQFEYYKKLSSNDRGIVVFNTNDNISKKGNTKMNSKDAIEHALFAYKKFIVPYNFSKIVIIAHSYGGTVTQNLLETFDDLNSNIRCIVLTDASFNTKKVVEKKLKNVPPIINYIISNKKLGEIIKKDDCIVYASAGTEKHERSSGVCVEAAINYINSYLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8N7</accession>
    <name>A0A0N5B8N7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UNC93-like protein MFSD11 (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8N7"/>
    <dbReference type="WBParaSite" id="SPAL_0000241000.1">
        <property type="protein sequence ID" value="SPAL_0000241000.1"/>
        <property type="gene ID" value="SPAL_0000241000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF13">
        <property type="entry name" value="MFS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000241000.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49984" checksum="04FE761BF70B31D7" modified="2015-12-09" version="1">MGRLERNFRNVIQLAAAFCFINFGIYCHQYIFKEAVMAMWDSDNLELRDKASDVANTLFYIAFGISSVLSPAIIGLLGAKVALLTGTALIFSHVFTMIIFKPWLCFLTSTCQGLGSGFIWGAQGKLLKLNCTPRTADKYTNTFFGICYSSTIFSSIFLLCIFIITNRTDGYNIDTLITAYLIMSLSIGGGFITIFFLKTPSKNEMTSISITVEHGTLATNTYVEIMFNVFRVLFKKEFFKYAVLFTHFGISCSIWSSIIPSTISASIEFGNHRFYHMACCCFVQGTSQLLGAFFFFFYGHKFRRLTRLRKAYLGSIFTFLAYVFILLTIPPKSNQGRTNGKAHIQITSPIFPYIPSILIGLGDIIFKIQATTHIMDVYPDQSGEVFSLFNGFQGIGMALIFILNIYITLDIIMSITSIYLMFALFCFYIADRESFNYTTLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8X5</accession>
    <name>A0A0N5B8X5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8X5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8X5"/>
    <dbReference type="WBParaSite" id="SPAL_0000249700.1">
        <property type="protein sequence ID" value="SPAL_0000249700.1"/>
        <property type="gene ID" value="SPAL_0000249700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="11">
        <location>
            <begin position="935"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000249700.1"/>
        </source>
    </evidence>
    <sequence length="1012" mass="117164" checksum="3F6217E72A4043FC" modified="2015-12-09" version="1">MTSVFKNSTNGYNETFDVLDTDFNIASASPDEISRISSTLSDVIGIDEGTFRRCLDDFCDGTSNNRAQVEAFLMAVYCHKLSQVKADEEVNPVTSKMQAYFGFSFTSEIGSQLENAFCKVLMTDFENVINGSCNEFLDVKVRKLLKGMAFIIVQCFIKIVVDEVFCFSLSKNIFIDGFIYQLSKVDKEPAFRLLVKFMVEHLSVDTLTSFYTPIFQKLRKLAIDRRATRQIALTSTQVIHAELQWFPLVILSRLISLDENTKSPFNLLDVLANQRNFCYDFSLKDTPCYMSMDTYLGPFFALGIFDNGDMECSREMNRIFEGQEVEGISNSALARQIRDIHSNIRRHLLTICQALVTKTTTRQVTTQYLVDVILATEGRGKYHFEKSEHVGHVFMMNFLHVVISLASKVRLENLDFNYLARRSCQFPVHDLTKINMTTQEGEDFCKQFDGQEEKFNFNTTIFYVAIFAIHTGFQPLINEFTSCKRDWGYVKKDLKKLRETYEREVERGNHSEIIRTFMQFRMHEESTRQLKYCLMSSIVMLYDQAITRVLAPFMDKLSLFLLDTLHPDAKKNFIPDTASDLFKFLPEMIIEHILSIFQFMETDRSGNGYCLPLVQRFLIVLSVSPHYFKAPFNYAKFLEVIVQAWSHARTQMSLNYYQQILINNSTNSKITPILLKFYCDVESTGASSEFYDKFNIRRCIHFILERFWEHSNQKLMLIKTMNSISQEMLRFANIVIGDSTFLFDEVVGGMKKAVSLEKELLELRKNSSRDTDEIKNKQSKYDEAVRGVTSWIHTLSESLDLLKKLTDYSPKVFMNQLIGERLAALLNYNLVELSPPNHLAFVSWKNLANELGFSGRALVTKIIAVYNALSTQQFAKFVAFDERSFTSERFRNIFNGIRDVFGISGVLMERFSVFLQMAYIEYDSKMEEEEDFGDDVPDEFRDPVMDNVMLDPVKLPSSGQIMDRKNIIKHLLNIQIDPFNRQPLKQEDLIPLPDLQKKIAEWIQEKKKARQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9C7</accession>
    <name>A0A0N5B9C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9C7"/>
    <dbReference type="WBParaSite" id="SPAL_0000264300.1">
        <property type="protein sequence ID" value="SPAL_0000264300.1"/>
        <property type="gene ID" value="SPAL_0000264300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000264300.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15261" checksum="E40360C4F807AE69" modified="2015-12-09" version="1">MDTKKEILIVELKEVDGVRKHILKYVSTFSDIESLAKTCRCLCLLISGDPIGRDIRSLSDDGYLTIQFKRGFKNAYEVPILERVNITKENYLFEDIEERNRRYVETIVTGNQTFLELAVVFLRLLLRKVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9H2</accession>
    <name>A0A0N5B9H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Baculoviral IAP repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9H2"/>
    <dbReference type="STRING" id="174720.A0A0N5B9H2"/>
    <dbReference type="WBParaSite" id="SPAL_0000268800.1">
        <property type="protein sequence ID" value="SPAL_0000268800.1"/>
        <property type="gene ID" value="SPAL_0000268800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000268800.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18104" checksum="29BDAA6329555E87" modified="2015-12-09" version="1">MLGKHFSNLASLRSFTDPEVSDLLLTVNRLKTFKGWPFDTVKGAKCNSLELAKAGFFMTMTDESAPSAKCVCCLKDLQWEEDDIPLEEHLRRMPHCVLAQQVSKKKEANMTVSEALYILSMREATMAVMGQLSEDLSMIDTGLEYNQNFVNKVSKKTQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Q0</accession>
    <name>A0A0N5B9Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Q0"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0000276600.1">
        <property type="protein sequence ID" value="SPAL_0000276600.1"/>
        <property type="gene ID" value="SPAL_0000276600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="802"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="960"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000276600.1"/>
        </source>
    </evidence>
    <sequence length="1080" mass="124850" checksum="4F6BA4608D42DFB6" modified="2015-12-09" version="1">MVACSNIVILIIFFYLSLYVLLGISFIEGGSNSSTTANSSIFGSDIILIKCNGSDISESNSTGDGKISTPSIVKIKQEPYLIVEYRKSNLNISEHNNCLEGWNENTNLTMVGWTNESQLNIVREKIDYTTIKLNESSEDLFITHKNKNNSLKRGYPSFINSFDGLIIYHFNVTVHNGSIVNPFKISNVINGPISYDVLDYDTFFNTTIKNEISNSSTLILSNVTRIDLEISSEKDKEEFFNKYDITLNYCLIINNHSELSNSSNLPNISIFDNDFTLHNDIFYYFEVKCKTCEEVYHKLQDQYFLRKKCNDSLFDKINNETKIRMKCNKLLDNQPQGNEQIRNVTYTNGSIVYNGITAPVKVLTDQCPNLSSKNIPRNNDPNPHDYLPDGDYNKQNGTTGKNVENEKSKGKKSLKITIIQIFFFIFLILSVIIGAAISIRWCITYFIKKHNIQDDENNTILKKNKIYPNIQEWWNNLVSTNFVIHCQSVYDFEYQSTLIEDFVMPDKIKELTNKTIDKKEGSNVKALSKTVTTKEKHRNSYTISNVSLKRNYIMAKKFYCPSKPKKYGEVHLEFMEVNQLQNIDILFIKLKLTHSSGLRRRLWVYFAPDVSDIHKPPSKGVDNKKQKEDAVNNLNIIPYIYEHILKSCGSRKILIHSDNEISKSVLIVTYFCCVVDGMMTDFSITNPLKIIKKVRSIHNSHNFGAIDYGYLIRILTRYFCSENYMLHTDYETSIDNAYNKYKILLGKRCNKEFYEMLSLENIQDMIYGLWKNYIIGDKTELESKCKTWFEIYKLPISKQIIRSNKFSCFEDDCIIFDNQKNSDQYSGFLNGNFIEYGSLQNIKRRLIMCQAPTQYTYMSMIGYLYSETPATIVITTGSNEKLNDIAPYLFKNDNKNKPIAEEYTVDVGKNLLTNLSSKEFIENCDIYQMTIKKKGEKNTVEIKVFHYKEWPQRGIPLNYQDIVKLIKAINGYGRTKSILIHGKDGIGRTGSIATLLYMIDMIEVNNEFNPLDHLNDIRDCRYGAVETREQFLFILMVFSEIFRDSIEVVNPGATNRYLKLLHNLIYIDFRTEIDKKGGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAP4</accession>
    <name>A0A0N5BAP4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAP4"/>
    <dbReference type="STRING" id="174720.A0A0N5BAP4"/>
    <dbReference type="WBParaSite" id="SPAL_0000311100.1">
        <property type="protein sequence ID" value="SPAL_0000311100.1"/>
        <property type="gene ID" value="SPAL_0000311100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="25"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000311100.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57785" checksum="34555743B265FBFB" modified="2015-12-09" version="1">MSGKEPADVQLENFKDSQSKREQLTTSYGAPIGNKLASLTIGKRGPMLMQDVVYMDEMAHFDRERIPERVVHAKGAGAHGYLEITHDITKYCKANIFSSVGKKTPLFLRFSTVGGELGSADTARDPRGFAIKFYTEEGNWDLVGNNTPIFFIRDPIFFPSFIHTQKRNPQTHLKDPTAMWDFWGQRPESTHQVMFLMSDRGTPDGYRHMNGYGSHTFKLVNKNNQAVYCKFHFKTDQGIRNLPVDVAKKLASEDPDYSIRDLFNAIEKGDYPSWTFYIQVMTFEQAEKCPFNPFDVTKVWSHKDYPLIPVGKLVLNRNPKNYFAEVEQSAFCPAHVVPGIEFSPDRMLQGRIFSYTDTHFHRLGPNYNQLPINCPFRSRAYNMQRDGNMAIYNQDSAPNYHPNSFRGPSENKIYQESTFNVSGDVGRYDDGDEDNFSQAAAFWNNVLDEGARKRLVENIAETMKGVNEAVVSKAIENFRNVDRKFGEMLRSAVDKINSNIKVKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAV1</accession>
    <name>A0A0N5BAV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAV1"/>
    <dbReference type="STRING" id="174720.A0A0N5BAV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000316500.1">
        <property type="protein sequence ID" value="SPAL_0000316500.1"/>
        <property type="gene ID" value="SPAL_0000316500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000316500.1"/>
        </source>
    </evidence>
    <sequence length="774" mass="90123" checksum="58EC5F46A1D3F3C6" modified="2015-12-09" version="1">MIKNDLLWRKYFTLLEIIDNYSESTYDLWQNVTSLDQGIVKALKNDKRIHLYTINNPKLKDISVVSTNPLKNLIGRSWIKLIIFNDGISIIDKNDYIFLEFPLLWIIEKDTGENNNNDNNTFISIISPEYEFELDTNDVNIKNDLLKASTFWYNYSLFIKLLSYHKETGFFEIPPNIRFVTYKFSSSHQVFRNATYTGLWKNGKPHGKGTIVFPGGKRYKGNFINGLIEGYGKLQVPVDNTPSTTTAYFIQNVFFSSVELHPLSIEELKKKKYDYMEGNFKNGVLHGLAMIRFANGDTYRGYFKNGHREGFGINCQLSFGVGERMYCGNFKNDMKHGYGVYSTNHEKYLGMWENDLRHGKGCQITIDGVYHEGIFDKDRFIRGQMIYYCENLLTTTFSGDFDKEGITNGKGILHTSPFDYIEGYFQGNILSNELKISNGVYKRKDDVLLMDPILRLVSSVLDETIIDVNENVGDIGERWLGLFTHFLEDHFKIECSIEELESLQNIEKNEIWEIMLSSCKNIKQQLMRENNIINVNEEEEIVPEYNLPWDTKYYGMVDNYFKKSINLPYNPINRLVKGILEVFTFAYDKIGAHKCLYQQIVVELHIIIRRLYIIMRFLFPNLPSSENMYNIVGEIENDGDTNKTFDSEYNIPACNFIGNYFFIEGYAVLFTVFQMHCQEADQKYFERICFLNTFNDSKLSDMMGLSDYLKPSSTTINDTTLPYLEYYKTAIHIFQTLSGHCNPVKKLSILEETFDDILKVCFPSKFINIKNIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCJ4</accession>
    <name>A0A0N5BCJ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BCJ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000374100.1">
        <property type="protein sequence ID" value="SPAL_0000374100.1"/>
        <property type="gene ID" value="SPAL_0000374100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF159">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000374100.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35564" checksum="5C0B78AB30B8D9A0" modified="2015-12-09" version="1">MKIDHFDVVLEKEEDSPYIGGDFIVGSVKINVINKIEISKLTVSLRGIIQTGWKNKKSNTAIFESVVELLNETLDLTSEIMQHCDDKCHLQCGLHLISFQYKLPFAVLSSIEQENLGYIRYTIQAILEIPEDGFSEIIAERPIKIFSYLNLDAPHLLNSTTASDKSEVPVCCGRCRGKKRIINTRVTIGQLGIFPGDQCLVKIEVDQEPVVSCCNPLKRHKNKETKCISVSFCQQATFKSRNRFDPKIFDEKSITLALASQSFHHECDSNSTLIKNVDFDVPEKIPPXXXXXXXLKYLKRQMIYFHKLRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCT0</accession>
    <name>A0A0N5BCT0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BCT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000382500.1">
        <property type="protein sequence ID" value="SPAL_0000382500.1"/>
        <property type="gene ID" value="SPAL_0000382500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000382500.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40111" checksum="5B1125CABF2C6709" modified="2015-12-09" version="1">MGGKSKRSGGGNPGSGDRVRTHLLFGQKSEHHTIKRKRRTHNRLMQNMHKKDEMVQAGPDEIDPSLWTGNQRVLHFGPMAQRDPFFYYYPKGWDVLYPAKFGFFPYRTNKFRGSSYVVCLWSFGIFFLIGSLIMIYLGYFVMHDSPFWTWPPEKVQFLPPIQIAGPILFIISCLLILIGIIASLLTSTFLNEKLRHYYHKNQPANTTVLIKHFPQSNGIYERNPYQPLPPPAYPVLENRYARSSFLNARSELKLYPPVMPGYSTLFLHGKQNTPFLASPYTTLRAISLTRFGVGSEETSQSNTSNVKTPLSQRKRSNISQETQKRSKSIGPSFRGSFSGRRIKEKEGSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCW3</accession>
    <name>A0A0N5BCW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TMEM135_C_rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCW3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCW3"/>
    <dbReference type="WBParaSite" id="SPAL_0000385800.1">
        <property type="protein sequence ID" value="SPAL_0000385800.1"/>
        <property type="gene ID" value="SPAL_0000385800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000385800.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51443" checksum="C0D9DF97517E63A7" modified="2015-12-09" version="1">MTVVSKFVAGTLGLRILHGTCYEIGHTWNPNCELAILDAVRDGLVFSFKTYFPLYLIASIAAKKSLRGAINYRLFINAIRSSIFLTCNMCFYVYAICLFHRLLGFSTVPTSGIMSASIASFLAILIENPSRRHALAIYLTNLATETLFRQGIVHGYLPRIPHGEIIPFSIGLGGMMYYYKKQKLDGFLSKIMEIVFRNTANEEIKAKTYYNIRVITVILNFLRRNYGKSSNCKHENSCLSHTLEGSVKNFSIGLSASVVLSILGNIKNLPKNPMKFLSSIFNRKLINIPLFFTALPAIQNIIQCLLNRYMPNKYKNLNPVIGAMISGLSFPIFPNLSVGLYFFWKFIETFYKDMMERNYFPRLKHWKELLYTISTGYILSIAIFEPHLLRKGYYNFLDKLTGHKIRQFNRRIYDHIARFGLNSNKLYESKMILVDTKYALINPAFYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD28</accession>
    <name>A0A0N5BD28_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BD28"/>
    <dbReference type="WBParaSite" id="SPAL_0000391900.1">
        <property type="protein sequence ID" value="SPAL_0000391900.1"/>
        <property type="gene ID" value="SPAL_0000391900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF8">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000391900.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22511" checksum="3CF29ADC0C317B98" modified="2015-12-09" version="1">XNEVLAYMPKPTSLARSLRNQRLSNHLPNPVDETFEIPENYADFLLYDTGAENRNRILAFGNRDLLLQLSQLTIIGDSTFDNSPNIFYQLYTCHAKVGNSYSPCIYFLLPKKDKKTYLEMFRILKKLIPNMAPEKILLDFEKTTMNAARHAFQDADIKGCFFHLSQSLIRKINSVGLKSVFESDIQVKLMLKSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD98</accession>
    <name>A0A0N5BD98_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD98"/>
    <dbReference type="STRING" id="174720.A0A0N5BD98"/>
    <dbReference type="WBParaSite" id="SPAL_0000398700.1">
        <property type="protein sequence ID" value="SPAL_0000398700.1"/>
        <property type="gene ID" value="SPAL_0000398700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000398700.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15338" checksum="0C8D4FD40CAAE53C" modified="2015-12-09" version="1">MWAIRKGYDGKEYSFSAQWTFTGAFFYFLTVVTTIGYGNTSAKTYFGKTLTILFAIIGIPLIFLFLTNIGDVMAKVFRFLYARSIRFKYNVILWHKKRQAAKIRKANSFVAKLARTQTMRQCMFILNIYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDI6</accession>
    <name>A0A0N5BDI6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDI6"/>
    <dbReference type="WBParaSite" id="SPAL_0000407100.1">
        <property type="protein sequence ID" value="SPAL_0000407100.1"/>
        <property type="gene ID" value="SPAL_0000407100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000407100.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17809" checksum="69107C7718EAE501" modified="2015-12-09" version="1">MGFIVLSIVILIKDDSTTNVAYSSISVNKFIFVALVIALFAMLYTEMVNCFTYHFVKRSFETGYSISAARPFAQPSGSISEHHRNSRDNSPFDFNIDQGNRIELTSRNQERSLDDNVIAKRNHTSSHNQIQKVLPLMYLFYFTLFIDTANRLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDT0</accession>
    <name>A0A0N5BDT0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BDT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000416200.1">
        <property type="protein sequence ID" value="SPAL_0000416200.1"/>
        <property type="gene ID" value="SPAL_0000416200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="128"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="321"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000416200.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42313" checksum="AE366E5F78B74ED3" modified="2015-12-09" version="1">MMGQTPSRNETRNESRNESRNTVLGGTSPDPNREEASLFDFIPEDNEFGQNGRSVGAGDGSQNPSSIAIRNRLAYRFSLHRIHQNLLQFNRQPSSQGPSVENSRRQLKLSCKLGDDEYKEYYDADIGYPEKFKIIIEGGPPDRKVMEEHAWNPNDSSLNIYVKDDDPLTLHRNPVAQSTDCIRGKVGFKKGFHVWKITWPLRQRGTHAVIGVATKNARLQSVGYTSLIGSTVDSYGWDIVRLKCSHDGRNNVHWGYPNENWNNYLGIGESFSVPESIYCILDMDEGYMAFATEEEYLGVAFRGLRGKELFPIVSAVWGHCEITMEYMGGVPPEAPSLMSTCRRAIRSHVGRRNLYKIFDLDLPNSCIEYLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE73</accession>
    <name>A0A0N5BE73_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE73"/>
    <dbReference type="WBParaSite" id="SPAL_0000429800.1">
        <property type="protein sequence ID" value="SPAL_0000429800.1"/>
        <property type="gene ID" value="SPAL_0000429800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895">
        <property type="entry name" value="PROTEIN CBG03177-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895:SF17">
        <property type="entry name" value="TIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000429800.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30798" checksum="0BFDA4A7DBBD0213" modified="2015-12-09" version="1">MIHIIAYLCIFSCDNTNNKIDVGRRSEIRQSPKSYRIDTVTIQPPTLKSIKHDDGDVRIKEVKCPSVCMPKCTTKCLKAYMFINNPNYPFYMDPNRYSLKSISESVPLCHPLCMPKCSDTCLSELPSDDSLPSTNLLCRQACMPKCSPVCVASPPSIIPCERPLLNPNRCDCSPGYVQCSEATCCMRYKKMAIKYRNLLPSYLDADDEKMEKKFDKDVFSFVRDGLVPDYINGNETNIYINFLRRLGGSDKDNNEKLIKNSIFESEGSGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFC9</accession>
    <name>A0A0N5BFC9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFC9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFC9"/>
    <dbReference type="WBParaSite" id="SPAL_0000469600.1">
        <property type="protein sequence ID" value="SPAL_0000469600.1"/>
        <property type="gene ID" value="SPAL_0000469600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000469600.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="72064" checksum="1FA3641660B13798" modified="2015-12-09" version="1">MNDSSQFNCEICFQSYTQVGSLHSIACLPCGHIFGKNCLFQWLESKKPQVICPKCKKKFNGPPHSKDKFEDYIITIYGLPSNGDIPVEYEDFSDKLFQVKRELLEVKEENSKLKRELDSLRKNFRYLSSQQSIRNSLFSSYTNFNNFSNIGNRLRSYRPNSTNPSIIPGVHLNTRQRRGIIFDYLSRFANVPFGGSTSNRYTDSVVSNPPSPNNIPEFIISDEGEHTEEQITDENPRDTIPLEPDEIVIVSDDEESISEANNVEFQEFNIFNELGNDYPNELSSSNVAAVSFTNCIYSLKCENITDAVLVDETVISACKLSTEDNSLVSYGLKFFSSKGNYILRFSSEPINGIDVVKSRNNSNRFNILVASSRNLYFVKFHAFDFNAVVSKILNHTVEITSLAWLSHEQFAFGTSDGKVIFGGIGTHIDIYRSRKRPLADGVSESKTPIVQLRGATHGNVFGVQGNKIYLYHRDSKKSLIKEYDTDVKFIDMNGNKDKLFCFLTDGSQTLKVVPYMIVEHIRTQRTHLNVEDNLLSQEYQYNTNCIKMKSSIFEYANQHDSFVGLFDYDKNSSQLLVRFFNRNHDGKLSLQIREEPLKVVVNILSNKITGGETLKFAIITSEDIHVYGLNCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFG9</accession>
    <name>A0A0N5BFG9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Required for positioning of the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFG9"/>
    <dbReference type="STRING" id="174720.A0A0N5BFG9"/>
    <dbReference type="WBParaSite" id="SPAL_0000473500.1">
        <property type="protein sequence ID" value="SPAL_0000473500.1"/>
        <property type="gene ID" value="SPAL_0000473500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000473500.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14900" checksum="3424EB00B13ADE67" modified="2015-12-09" version="1">MAGNQKRLEELQTILDQQVKKFETMQKERDINIAKRQQLEVQLTENQMVQREFKLLNDDATVYKLIGQALIKQDLAESKDNVEKRLEYIGGEIKRVEKYLEEMPEKLKSQQDEIKKTQMMISSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGN6</accession>
    <name>A0A0N5BGN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGN6"/>
    <dbReference type="WBParaSite" id="SPAL_0000513600.1">
        <property type="protein sequence ID" value="SPAL_0000513600.1"/>
        <property type="gene ID" value="SPAL_0000513600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894491" evidence="2">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000513600.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25076" checksum="EBDDB38BE1837193" modified="2015-12-09" version="1">MQLKNLLFLVTILSLSKCLKGARYCEHKLTLTGKHSNTAITTRITEKSINCGNFQCMKYSLNIYEDDGSFTMEYRGCFNETFLKMNGNKNIKCGMEKKLDEQLKEVKKNSDVVIEGYLKKNKTNNTHTGEIDNNRPVYANLIKNSSGIDLSDKEIRKIEALINEGKQTDVTVDKVFTRHKAGGTFSIDCCNKDYCNMSGITKFSIGLIMSVIFLSLFVMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHF1</accession>
    <name>A0A0N5BHF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000539300.1">
        <property type="protein sequence ID" value="SPAL_0000539300.1"/>
        <property type="gene ID" value="SPAL_0000539300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000539300.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9329" checksum="A8529988756EECB4" modified="2015-12-09" version="1">MILEKEVTLLCDAEIIAFLNRRFLLTQNFIETILKYQNERENNTSLMNSYFVIKNELMSIIDRKERDDKKFSECLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHM3</accession>
    <name>A0A0N5BHM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C76 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BHM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000546100.1">
        <property type="protein sequence ID" value="SPAL_0000546100.1"/>
        <property type="gene ID" value="SPAL_0000546100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000546100.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47265" checksum="0B4D33F072CB9669" modified="2015-12-09" version="1">MCQAALGQNNQCVAMSSAALIMACIKPPINWEKFDINNVLNQGNILYERCVNLLRSKNDRMDPRGYLLVTNILRETILFNRKVSFSTASCYSFAGRGKNVKGDEIAFGFVSLSEALNRLVNEHQFLILIANERASSIMHHDGAFFLFDPHSMDQNGRYCSNGVSCMLMFKTLVDLIKYLQANQVCNNSVFQIDGVNISVEDISGNNPDVSASKNKVDSIVKALDSIQVANHSTKKRQKSKKYLKKEELFPARNEKIIPNEHYLGPLSTGCEHCQAMFYEKESKYKQCCEFGGVKEYERLFNNFPKFMKDLFIGEDEESIYFKKHCRRINNKFAFASYTGQQRDFKTSGPPTFVLHGEAKRVIKKAVPENKDNLSYGQLYFYGPDVAEDTKNKNANAFNEVIIISNLTHIISKINMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHR0</accession>
    <name>A0A0N5BHR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHR0"/>
    <dbReference type="STRING" id="174720.A0A0N5BHR0"/>
    <dbReference type="WBParaSite" id="SPAL_0000549700.1">
        <property type="protein sequence ID" value="SPAL_0000549700.1"/>
        <property type="gene ID" value="SPAL_0000549700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000549700.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="43527" checksum="55539F7E5B7A3E67" modified="2015-12-09" version="1">MISDNISTTYELSVNTKCGHGMEINTMKEWVAKYKQCPYCLIPSLPKDIIKIYYEDTINEKYYEYYKGKYEETMRISERKVENNCFTDKENIIDKFDLEMECKKNRRLKYLLNKEIGNGTDYKSHNAMEDMIKIEINTKNEEINILKLKIFEEQTNTISKDKNQAIKNKVLDLESKLKHHENEHFKYFSRLYQLQEEYNKLENENNFLKKQTKTMESIKELNDKINNQTAVIDNLTNKNESLIKEIKSHEKMIDKINKKNEKKFNELDNQYKELEKITEVLERNVESFDDKEKIFYEFDKKICNLFPVFNQKNKTIQMSRNTFLMEQQKLGSLAWKKVGDDIYSRIKNFIDTHPYLHINKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHW4</accession>
    <name>A0A0N5BHW4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit tim-16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulates ATP-dependent protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHW4"/>
    <dbReference type="STRING" id="174720.A0A0N5BHW4"/>
    <dbReference type="WBParaSite" id="SPAL_0000554900.1">
        <property type="protein sequence ID" value="SPAL_0000554900.1"/>
        <property type="gene ID" value="SPAL_0000554900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000554900.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14240" checksum="010DAC3A0D069DA5" modified="2015-12-09" version="1">MVIKNLVKIAVAGIEAVGRALGRAVKEEIKYTQQASERYRQQTSAAAENKTKAESKLGISLQESCQILNVKEPFDPKIIEENYKRMFEANDKAKGGSLYLQSKVYRAKERIDEELSIRSEKESSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI75</accession>
    <name>A0A0N5BI75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI75"/>
    <dbReference type="STRING" id="174720.A0A0N5BI75"/>
    <dbReference type="WBParaSite" id="SPAL_0000565800.1">
        <property type="protein sequence ID" value="SPAL_0000565800.1"/>
        <property type="gene ID" value="SPAL_0000565800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894646" evidence="1">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="308"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000565800.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48927" checksum="19C313ABD51CE3C9" modified="2015-12-09" version="1">MSILLYFLAASLALVPLSIYCEEVTNYFPSVPGIINETTFPVRLTVNTTSDVVLIKCPYFGYKHTNDSKEFSPNTFLRRSALTYNTDNELFAWIPLMKKSPGLINVDCGGVIFMNDTGNQSCHWKYDVYWGNYGNSSNLPEATFIPLMVPLMHTKCNSSPADEPLVFTKNKNNELVKVNSSNDNVVYIKKMFYYFEKPKEDDVKEVLEPCAITIAYSECPSIILPDFKSNFTIRTGLFNYKKYLSNFLSHQSSMNSDLEQFLSFVNVLDSGKLDEYEAIFTNIGTMTSMDLFNSCRHFYIAVRNKYVKKTRYSDIVCLDSTAVTIRGQPTTDMESFIHANKFVYNTSDQKERKLILCQGPLDDTRDDMLGMIFMYKISLVVILFKSEEAGSRYNKWTQYFPESNTTLVFGSSFVTKTNYKCTDTSCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIL2</accession>
    <name>A0A0N5BIL2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BIL2"/>
    <dbReference type="WBParaSite" id="SPAL_0000579200.1">
        <property type="protein sequence ID" value="SPAL_0000579200.1"/>
        <property type="gene ID" value="SPAL_0000579200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZFPL1-like B-box zinc-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000579200.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11658" checksum="94C224CFF8DF7DCF" modified="2015-12-09" version="1">MGLCKCPKRKVTTLFCYEHRVNVCEYCMIDNHKSCVVQTYLDWLSDSGYDSFCILCNQSFTERDTIRLKCLHLFHKDCLHAREANSASELGLRLNFLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJM7</accession>
    <name>A0A0N5BJM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJM7"/>
    <dbReference type="STRING" id="174720.A0A0N5BJM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000615000.1">
        <property type="protein sequence ID" value="SPAL_0000615000.1"/>
        <property type="gene ID" value="SPAL_0000615000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000181">
        <property type="entry name" value="Nanchung, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF30">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000615000.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="100581" checksum="87417963D0C1E3F4" modified="2015-12-09" version="1">MANNVKNEKMDIGEKGNQFNDKKNNEKKIYTLVDMYGKGELIAWMKYAANTGDHSFINECIESKVDDLMYNGGKGKVMAISELVKIRNQERNAMLGAFRKKKNKGKSGPNILNDFNQEGGQNQGDLKKALKLLDGGKGGKGDHKYREVVWKLDERGTMGENLLGTCLMQGSPIHMNIAIKLIKQYPNLVNDIFVSEDYYGLTPLHQAIVNEDSYMTGFLLQNGADVHARCYGAFFCADDQKSGRTDSLEHEYVDLPSKTNYTGRMYFGEYPLSFAACSGQVDCYRLLRAKKADPNLKDTNGNTVLHMTVIHEKLDMLKLAFETGAKLQVTNNQNLTPLTLAAKLGKKTMFEELLKLESQMIWSYGDANCYAYPLAKIDTINQETGNVNNDCALSLIVYGDTPEHLDLIDGLIEDLLDAKWKAFGRRQLLVSFFAFLFHYVFFFMAFMNRPFSFTTAVITGGSIQPNGSLNSGYYNYFLSNYSDWKRRMNANSTYDFDMDNDDLFQKDYFKTAQCHLWSYHIPEGFGYLRLVSEPIVVISVIVQVALEIKDFRHMGKRRWWQILKAFPAKLTYKCSWILILLMIPVRCLCGLHSYMLIFDNVLAIISILFTTIHFLFYCRPLKFIGPFVLMIYTIIAHDMARFVVIYVIFLVGFSQAFYLIFLSCEREDNINKGGNSFDNIVADPLESLQRLFIMTVGEFMLFYQTLNNCPVKTMNIVGKVLFLIYELGISLTQFNLLIAMLTRTYESIAGTHKEYKRQWAQVILALETSLSPKERLLALLKYSRPIGTDKKKRAFVVNKKNKSSNDDDRCEKEAKAEAMAEERRIILKKRLKEASTAFYRKYNERLSTPTPSMMNEPINDQIDHSNENKLEVESKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJR2</accession>
    <name>A0A0N5BJR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJR2"/>
    <dbReference type="STRING" id="174720.A0A0N5BJR2"/>
    <dbReference type="WBParaSite" id="SPAL_0000618300.1">
        <property type="protein sequence ID" value="SPAL_0000618300.1"/>
        <property type="gene ID" value="SPAL_0000618300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="149"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="353"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="304"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000618300.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="100963" checksum="B8581567BAF76DF2" modified="2015-12-09" version="1">MNTISSCELTIKVIDNGEILNINSPSSILSKSNVILLLQNTLTPYYNHTLEVKSKGNSDCHYESNSNGHVFLSINFCIPNIISGILKSNDDFYILSNKSGSYEIFQLTTNSHIICPSFHKHRHKRQSFKKGNFVRKPDYYDNYISDKKRYVELGLIADNSIYLKYNKDEKLVNARLQAIADFVNVLYSPLNIYVYLTYVEVWKDKDLINVSEESNVALQNLVEYRVKLMKHQPHDNTHLLTNKVFQSSVIGKAYKGTMCANDNSVGVDMDHNANPAYVAATVAHEMGHNFGMEHDAPYPDPCKCASPICIMYVASNLTLPNHWSECSLSQLSTSLSRGVDYCLMNVPKTKKGDSKCGNGIVEAGEDCDCGSTVHCDSSCCIPSTCKLSDNAECASGDCCDLTTCKPKKKAIMCRSPKSDCDLPEFCDGNSQYCPADFYVQDGVHCPLSPDSFCYGGYCGDRDKQCAKLWGAEVHNGVDICYKKLNVNGNEYGNCGYKNDTFFQCKEKDVFCGSLQCDNLNSQPIFGDPYSIRSVMSWAKEGEKTTVCRTFRTTYSINIKDRDPGMVPDGSKCGKDMFCVGTQCKRKNEVVATLPFCDPNDCNNLGICNNVGNCHCKYGYGGTACEIPGYGGSINSGPMHDTAAFRPFLWVMWFIIFAVAIFAGLSYYYKKNKNICLPKIIWKKFKNMLNIRGMLVPVRKAPAPPNRLPKPGENINAAWGSTEGGNEIHAGDFLTARFIPKPPSFKPPTCNYTDGGNYVQLSGPRNYFTCDRPKVPPPTAPIGDVTKLGTADNQVPYEIVNDGKINMNYSDVIKYPMNNININEYEMMNCNGTQRPSQPPPPVPKHGKKPQVAKKPVLNKKNNSVNTVTDGVDENIQLPREDKNKNECFEALPKINVKDLAKQFEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKY7</accession>
    <name>A0A0N5BKY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKY7"/>
    <dbReference type="STRING" id="174720.A0A0N5BKY7"/>
    <dbReference type="WBParaSite" id="SPAL_0000659000.1">
        <property type="protein sequence ID" value="SPAL_0000659000.1"/>
        <property type="gene ID" value="SPAL_0000659000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="296"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="298"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000659000.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40981" checksum="108BE625E8B8F238" modified="2015-12-09" version="1">MQAAMQSQASIAAVAGFPIAAAAGIIDPNRGYSMSTGSQRNLPANDPMALWSQASAAGMYNNSNIEGNTNNHQNTNYSNSHLMTSVTNPYNASVYNWNNSTSATSFPSPRSTNPLHGIGGTNTTTTSRPSSTTETSGNTSTSSSATTNISSPFSSGSFPGTVPTTSNNPTTTNNNNEVRSGSNSGTDQNNETIRNSAQNNVENNRSSTTATDALQRCFPPTNGFEMMQRMNPIYSNDIATAAAVAAVSGNNPWQPYSYNTYGYNPLLSQQYPGYFSAQDLSVVGDHSSLDWTGSHSRDRKKRKPYTKFQILELEKEFAFSSYVNKQKRVDLAQQLQLTERQVKIWFQNRRMKDKKTKARCYNMTMPVRQACINSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLM5</accession>
    <name>A0A0N5BLM5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLM5"/>
    <dbReference type="WBParaSite" id="SPAL_0000682100.1">
        <property type="protein sequence ID" value="SPAL_0000682100.1"/>
        <property type="gene ID" value="SPAL_0000682100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000682100.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43370" checksum="CCABA9C22200F704" modified="2015-12-09" version="1">MAGNKGTKRPREETKDDDIPTDSKRPRSYEDHLSHLGLNRSNERIPLTRASSESGFLPRKTSSVDTQYVGSQSEESEREDAYESSDVRDPSGHTVRFRNDKQTLEDNVIQLSTNNREIHLNNVAFTADGECIMIQLRVGSPEIAILEEVNLRRKKAKAVNPTQAACPRWRGSAKELKEKSKEIFGIDSPWLGDKNYFEHKAFQQFRCSYKNRDDGKRDYYIESSISTVIKEDIAKIHAPVYDEKGVMFYCAMRLMEEYSTCANYCINYVRTKYYDIVDRQTAKLLYPSKLSTITRPLFKVIRMILVKCGAKTWPPGRRQTAVDIMFNIFEDYLGIQFVPQVNREGVFANLSTRKNECWRLELVDDLRNPTANPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM57</accession>
    <name>A0A0N5BM57_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Troponin I</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM57"/>
    <dbReference type="WBParaSite" id="SPAL_0000700000.1">
        <property type="protein sequence ID" value="SPAL_0000700000.1"/>
        <property type="gene ID" value="SPAL_0000700000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000700000.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8629" checksum="42739C511B8AB70E" modified="2015-12-09" version="1">MPTWKGKKIEKLVARLKLSCEAKKSESELRKKAEEIFLAQTKEKNKKRREIKKEKKKEWERKKWKKMKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH0</accession>
    <name>A0A0N5BMH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000711000.1">
        <property type="protein sequence ID" value="SPAL_0000711000.1"/>
        <property type="gene ID" value="SPAL_0000711000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711000.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19460" checksum="B9B3A1E1893A628A" modified="2015-12-09" version="1">MENAEFIATTSGITPQLSTIGVKVKISDKTTIFTPTLKKFSLTISNYEFDYVGDVYRHTIEDQVNVVGIVARVENVCILTNEKLNLTTLRRIIFITDGTCVLPIYIYGELAYKNFEVKQLVGVKYGLVNQHTACDKIVSCNRSSYIIDVDNEAFIDLLLKSRQIEYESLTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN41</accession>
    <name>A0A0N5BN41_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN41"/>
    <dbReference type="WBParaSite" id="SPAL_0000732000.1">
        <property type="protein sequence ID" value="SPAL_0000732000.1"/>
        <property type="gene ID" value="SPAL_0000732000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894640" evidence="2">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000732000.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43819" checksum="D59CE23C492FA5E4" modified="2015-12-09" version="1">MKWCIYLSILFILFNDVNCQYKNFAEAKFDLPDNLPAEDPMFQLQKDQNYQTIQKPDIKIENNNFLKPNQLFNTMPTISLPQFPSPTVNGLGFQQITPSIQPQQPSGTLYLPEMLQLPSITEVNGMPQTPPLPFEEKEVKHLPTMEKVIPKAHPPMTLFSNDENKNTISAHAIPTFKSQTIHTHKSRFEGVPRIVQPSKSYKNPRNEKSIIPSTSLYDTPSSALENNDKGKNNNEIENYFLDTYNVTDCPRDSRYMADLFYQKFPKNVLAPGKDVELTTLLGPRLEQCYLKKEKKHWYKVETFFDKIGVSKESEETCKIGLIQEQIACMNLISYSCQFVQHDYQFKLIAARIVLGEARQAEAGENKCREVVRAIKNILIKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN43</accession>
    <name>A0A0N5BN43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN43"/>
    <dbReference type="WBParaSite" id="SPAL_0000732200.1">
        <property type="protein sequence ID" value="SPAL_0000732200.1"/>
        <property type="gene ID" value="SPAL_0000732200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000732200.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7380" checksum="B5300BA6F73A2C8B" modified="2015-12-09" version="1">MFSLTIELKLAGTGAGFQTNRSYKSISDRNFLFKATVRISSEDTDFKLKSGALSQTFPGISSVINTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNI1</accession>
    <name>A0A0N5BNI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000746000.1">
        <property type="protein sequence ID" value="SPAL_0000746000.1"/>
        <property type="gene ID" value="SPAL_0000746000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000746000.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39489" checksum="51CF811504D42E41" modified="2015-12-09" version="1">MRCCSPNQLETLQFPHIGKPNNKNEESLLYKFLPYAKSVRFNESISRHDYSSQHFSDFFSGTKIFTEPNVSLTYQINIRFSDAEFGRYYERLARNNLLLDEQNNHENTNAGYMSITDLCLGNILFYDNTSKLTDEEAFAFTNDILRMKNLRSLQIRFFTFSTSNHFYYLCKGLNRNLENIKLEKCSGMSIGDVEEIARNCKYIKNLILEDITSETISLNKITSLFKHLVGLRLKFNSCYNAAKIINDIKRIDENGNFKIAWPPLQFLHIHCAYPKTNQRYILRKMAKNTPRRCGQFLFDYLKPSTYEKEYILRIIIQSNTSTCTKFKNSFAKTYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPD1</accession>
    <name>A0A0N5BPD1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPD1"/>
    <dbReference type="STRING" id="174720.A0A0N5BPD1"/>
    <dbReference type="WBParaSite" id="SPAL_0000775700.1">
        <property type="protein sequence ID" value="SPAL_0000775700.1"/>
        <property type="gene ID" value="SPAL_0000775700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000775700.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45852" checksum="506CAE2A07B600F0" modified="2015-12-09" version="1">MKHWYCNTTNYYKLSNVIEHNINQFRFLALQNTAPHPDEMVELKEKTTKDLVDMKKKDLFTSKIIKLESNQNYNIREKLLGTPVKLSKKDSKKIIAIHNTDVGNGWIKMGAGNLVKTYMDLSKFRLTMLIATSTIGGYFMAPVAYDPKTLACCVIGTSLMSCSANAFNQMLESPYDSQMKRTQNRLLVTNKISPLHAFSFANICALTGGSLLYYGCNPLTTFLGLLNVGLYAGIYTPMKRHHIGSTWVGAIVGAIPPVMGYVAITGQLDLPALVLAAVQYSWQFPHFNGLSWNLRADYSRAGYRVMCVTDEKLCRKSTLRHSLALLGICSIAAPLSGLTSYTFALDSLPLNLAMCYFSYKFYSTPDAKTSRNLFKFTLLYLPLIMTLMVISRQDRVKSTTPTEEVNFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPN7</accession>
    <name>A0A0N5BPN7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF2335 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPN7"/>
    <dbReference type="WBParaSite" id="SPAL_0000786200.1">
        <property type="protein sequence ID" value="SPAL_0000786200.1"/>
        <property type="gene ID" value="SPAL_0000786200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000786200.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24666" checksum="D18744A1F1D62C6A" modified="2015-12-09" version="1">MFYEIENKKEVEELLKNENNKEVEMFLKQNEYTLSDIKKLKDSLPNDFPFFKVLDKITFCKPKVHVASEEFKKLTEKLKIERDNRAYKEMTKEVDASQRFGKVDLMSDFGKELKEVNRQGIAIFNTLITVGGSFAFGFYGITFMYPGLNLSFEARLIIGLFIATIVFFADLYFIIKGMDGKEAKKSVRAHKNKGPIQKDKKVLSKEKIGKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ81</accession>
    <name>A0A0N5BQ81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000805000.1">
        <property type="protein sequence ID" value="SPAL_0000805000.1"/>
        <property type="gene ID" value="SPAL_0000805000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000805000.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9028" checksum="7230B1DF7FFC6AAF" modified="2015-12-09" version="1">XNAILEFIYRNALLDDSLNPLPNFEAAVNGLRVVGISYADDTTLIADSDDSFKEMLSAFTYHSERVGLDINLDKSNYMALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQW9</accession>
    <name>A0A0N5BQW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQW9"/>
    <dbReference type="STRING" id="174720.A0A0N5BQW9"/>
    <dbReference type="WBParaSite" id="SPAL_0000827800.1">
        <property type="protein sequence ID" value="SPAL_0000827800.1"/>
        <property type="gene ID" value="SPAL_0000827800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="50"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="261"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000827800.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="77831" checksum="28E3652968C031C4" modified="2015-12-09" version="1">MVFSKVLVNENNCYHEVFYNSPNRFKDIKGQPLHNLGLRYELDPFQRRAHLAVDNNESVLITAHTSAGKTVVADYVIAMCLRKKMRCFYTTPIKALSNQKYNEFKEKYGDVGLLTGDVTISPNSSVLVMTAEVLREMVFQKKESLKNETAYVIVDEGHFIGNKERGFVWEETIIKMPREVRMCILSATLPNFSQIAMWLVELKGIPLHVIGTTERPIPLEYCFHCSDTQRVVHIKMADGPVNKNALKTAMSESKKNRGKKELQNLLHDMEAKGRLPVIIYCPSRKTCDSMSQLIASSTFLDETEEKLMKEAVEIALSLGDEKLKTAMSEINDYKERLLRGIAVHHSSLMKFTKEFIEECFVSGGIKVIFSTETLAIGLNMPATSVIFTSIEKFDGERKRRYEKSEFIQMAGRAGRRGLDSQGTVVLSLTETVNEKHLLDLLSPTSEDLKCQMNISYKEILFYAKTSSLQDLQETMNLSFWNFSKRGLENIFAMCNKKLELLKNEGFLTNDNKITAKGSIALSARFNPNYLAIGELLSSNAMSLMQYSGIIEIFSMLQKSDEAGNEDTKSVDSTHRKLVETQCEKIFNYEKKYGIVRPEAVFSSPVVLNYITAMRDIYRGKPIPEVSEVKYMYKGSLIKKVRELRLLLESLSKSYGFSNYTKEAFRTIAKTLKNVEKNDISMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR17</accession>
    <name>A0A0N5BR17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR17"/>
    <dbReference type="STRING" id="174720.A0A0N5BR17"/>
    <dbReference type="WBParaSite" id="SPAL_0000832300.1">
        <property type="protein sequence ID" value="SPAL_0000832300.1"/>
        <property type="gene ID" value="SPAL_0000832300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000832300.1"/>
        </source>
    </evidence>
    <sequence length="904" mass="105393" checksum="77BBF459C017D935" modified="2015-12-09" version="1">MEYYNPLLDTHLRGYLEKPCMRRHLKFLGLDDGEDSHSKNDIYSRHQHMMALLNRNKERHLAQLSDLSKKLEAVEKVETYRRIKKNGLLKNPHVRTLKRPMTSHDRAVIERIESNYRNNNEMKTRYKNVYEKLFSQSDKYNYLHKLDDLTLSEYKESLKNQVIKMEKIRDLTPWNTNPVMKHFNSSETSWFFKPKSLPNLTHSFTRSEGRFPVKSLKKESKRISRPNNGTNNLFGNKLHQNVVEGSRLPPLVRMPRKQKPNYMAQKLAPMNNKFPSLVISSDDNNKKEPDILIIDDTEKDNDEGSEIEVKNNDNKIIEKRGINDNELPMEDENIEKSNEESITSEQNIANNLNDEENKIDPIKEEHSDHDENNDKNVDDEILVQEEKLENEEGDKILSQDEKLEDDIVIDDNNERTSFDASDNANLNFEDIKNTSNLDEIKEEANDDNHEEKEKVIDEDEYTIDESDEDNDEDYEEEDEEEDEDEEEEEEEEENEQEEQINKNSDIAGDIDVSENANDENNSRIVNFNDEDRKLDTIKENNLPSDDDNEIIFHNSFVINREDNNDNTSVKSEEDLIDLTSPKVEEEKKDELNEFIAETKGEHFNNDDKNKESVAFVIENDNNEEDNVNKESIAFEIDNDNNKEDNPNKESVAFEIENDNNEEDNPNKESVAFEIENDNNEEDNPNKEPVAFEIENDNNEEDNPNKDPVAFEIENDNNEVDNLNKEPVAFFIESDNNEKNEADKIHESDENDLKSEIQNNNDEDEKITFDQTATDSVDIDNNDHNKSENHFQNKDDVFEESEKNETTDDIIKDETDTKTDNIYNNDEEEKVEDEEEDEEEEEEEEESTNKTLSPKNTGKNNADDSQEDLSNEHEKIKGNNTFISPSIKVQAPSEAGDISDNDMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRC4</accession>
    <name>A0A0N5BRC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional repressor scratch 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRC4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRC4"/>
    <dbReference type="WBParaSite" id="SPAL_0000842500.1">
        <property type="protein sequence ID" value="SPAL_0000842500.1"/>
        <property type="gene ID" value="SPAL_0000842500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000842500.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37557" checksum="BBA32826C5828B4A" modified="2015-12-09" version="1">MNNLQPLMNEVLANFAANINFSSNANTHQPTTNNTIFPSSFQMLNSNNNNVILPSLYSLQLYLLSNQLNLENLFPISGEKQLSPKIDSPPFIFNSPINHEITDTTREISNSNHNSFSIQNILSQNIKNVSNNINSPKLSLTNNESKIGEKNNIETVGYTMDALLMTDGRSKKKKYQSTSPDSIASQASTSSKHVCTECGKSYATSSNLSRHKQTHRSLDSEHAKKCPHCDRVYVSMPALSMHLLTHKAQHKCTVCDKVFSRPWLLQGHMRAHTGQKPFGCAHCGKKFSDRSNLRAHIITHTGIKKHKCDSCGKMFALKSYLNKHKELVCPKSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRI4</accession>
    <name>A0A0N5BRI4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Palmitoyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000848300.1">
        <property type="protein sequence ID" value="SPAL_0000848300.1"/>
        <property type="gene ID" value="SPAL_0000848300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000848300.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24574" checksum="1C34907121E467C1" modified="2015-12-09" version="1">MFAYIVSNFPCSIFLLLFFLLLCTSTIYSFYTCDDYFLLPLMSLLLIGHITLLYIGLCVFVFTISNLYEKQDYNESIFGFMINNNITERFLSTNILFNIFEIIVYLFLSGIYIYQFIIMWRCMEFFEIVKHHPTYCAVSMPPAYLSQLSLNSVNDKNNSLINVSVIGCEDFGKNDIKLCNKTVEKNWLESEQKDEGTEKFYKSLIDINLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRX4</accession>
    <name>A0A0N5BRX4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRX4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRX4"/>
    <dbReference type="WBParaSite" id="SPAL_0000861900.1">
        <property type="protein sequence ID" value="SPAL_0000861900.1"/>
        <property type="gene ID" value="SPAL_0000861900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000861900.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="50283" checksum="26BD72CC610B0498" modified="2015-12-09" version="1">MSTADTIVASNTDKSFLCEICSKAFRFRSNLAEHRSVHSNLKPYVCGWCGKSSRLKGNLTKHILKHHKAEQNAYIGTDDIIIKKGKKSVKDPAAIDFLEKSMIVLTPNSTNNNNNNNLPNSGLGMGEKHSDGIENLGHFLASMKNRKRAHSSDDLDDSIDGERDKFLMSLGLEINAGAINSNSPTNSAESNSGEDKGENVGSGNNVPDFMNTLTSLAAGSSFSNPISLEKLIDTRISNCSSPSRNSIASNCNSTKTQCPQCGKHFRKQSSLQVHMTVNHGAPPPGSSRNSNVSQELPLEQSPSPSSSTEIKLESIETPVIHNPVNTVTAAAAALSSFLMNQNNNTGNVLSNNSKTTSSSPAFGISFDSKNVNFQNIQGELKLIKQTIHEINRNHLDSVHKLEKSLTTIDNRVDRLEKQLEMALNSIYTLVQLQTGINTNVTRFRDDACEKLKSVKALLSETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT43</accession>
    <name>A0A0N5BT43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn_Tnp_IS91 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT43"/>
    <dbReference type="WBParaSite" id="SPAL_0000903500.1">
        <property type="protein sequence ID" value="SPAL_0000903500.1"/>
        <property type="gene ID" value="SPAL_0000903500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF10">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000903500.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="23728" checksum="16C2E2102B923E12" modified="2015-12-09" version="1">MKITQDEITDGRIDRLSEWKVFMIKQHPVNRFLDVYMRFCQKYREKNKVKCLNCFSDLNCIISKMYKLIDKKSRNVMDKSYHEEYFFPYTWNFSPIEGIDINIIDMENDNQMKFKIGKELIHLNISTHNIKDTFNIISNFSKSYADRKNKIRRKLNGETLYYNKLLLRKFASMYYCDFKYFGFDIPQFKKLMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTZ4</accession>
    <name>A0A0N5BTZ4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTZ4"/>
    <dbReference type="STRING" id="174720.A0A0N5BTZ4"/>
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        <property type="protein sequence ID" value="SPAL_0000931900.1"/>
        <property type="gene ID" value="SPAL_0000931900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000931900.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26363" checksum="95E32C8E891BE96C" modified="2015-12-09" version="1">MTKLLLDPGIRTWVFVPIITLSFFIGIIKHYVHVLFSTKKQAELRSVKDTHYLIRAKLLREHGGFLTASSFQARKEFYCDDNSYFQERMAMPDKKADPMDPTAMMEMMKGNVINMIPMIVIGGWVNYTYSGFVTLNLPFPLTHKFKQMLQRGVDLTGLEASWVSSASWYFLNVFGLRSIYTLVLGENNANDTMMESQMAMAGAGMPGQQDAKNIIKSEWEHLQTCNYICAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVE0</accession>
    <name>A0A0N5BVE0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVE0"/>
    <dbReference type="WBParaSite" id="SPAL_0000980300.1">
        <property type="protein sequence ID" value="SPAL_0000980300.1"/>
        <property type="gene ID" value="SPAL_0000980300"/>
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    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000980300.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16038" checksum="D917F81921348E51" modified="2015-12-09" version="1">MLIFGLGIGVVLILTIWLFLLIISLVYYKRGIKVILPNIIIGIFLSTIIVIWPKEMCNEEKSIKNNTSQENLVNSVYYPIFFSVPLLIVTTITIFVAEMKHFQMTFLKPFDNKNLSTNILLQNMNMQTKTNDTDTKYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVE4</accession>
    <name>A0A0N5BVE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVE4"/>
    <dbReference type="WBParaSite" id="SPAL_0000980660.1">
        <property type="protein sequence ID" value="SPAL_0000980660.1"/>
        <property type="gene ID" value="SPAL_0000980660"/>
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    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000980660.1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7468" checksum="B133B14965F6EBB2" modified="2015-12-09" version="1">MFLSLELIRKIESIRENGLDISCIRLAKGNAKMCPIAVLTEQFMLIKSWQFRLHHSMLIYSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVN2</accession>
    <name>A0A0N5BVN2_STREA</name>
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        <submittedName>
            <fullName evidence="6">Transthyretin-like family-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVN2"/>
    <dbReference type="WBParaSite" id="SPAL_0000988800.1">
        <property type="protein sequence ID" value="SPAL_0000988800.1"/>
        <property type="gene ID" value="SPAL_0000988800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000988800.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17358" checksum="C0FCC201E3CD03CF" modified="2015-12-09" version="1">MTNILLIKQHTLTLFFSLFNILVHSFFGTRQGIEVTGRFLCNGKPLIDTPIQLMEEDVFSNDILARGKTDRNGIFSLYGFDYEFSLIDPFIAFKVECPKEKHFFDNKTINMYVPVRAFKYFRRHYEFFFDFGKYEVNNITNQDIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWG2</accession>
    <name>A0A0N5BWG2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Connector enhancer of kinase suppressor of ras 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWG2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWG2"/>
    <dbReference type="WBParaSite" id="SPAL_0001015700.1">
        <property type="protein sequence ID" value="SPAL_0001015700.1"/>
        <property type="gene ID" value="SPAL_0001015700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="5">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001015700.1"/>
        </source>
    </evidence>
    <sequence length="981" mass="113461" checksum="DFC409A5BE87ED6A" modified="2015-12-09" version="1">MLVKHLDKRRLQYFTYNENYDVLNSLQYIVSSWNCDQFAEWLKGVDDGIIAYIPKIKKANIVGKNLNVIDEEYLENIGIYSFGIRRIIMQAINSLLYFCRDIEKDNLQKLMMICVSKLDMLIGCVQKVQTTPEQIKNISKDNLRLNVYTFLNNTYSNLAYVVDEVKKIVFWLDRSPFDRLDMYIKIREKILNDCIDLAKVVSLRSRNILKTNSIYTKAKKMKEYLLELIRSRNDPIFVCTSFTERAVVKINEQMECGINIQSSFRGVHVISEIRADSPADQCEKLDAGDEILQINGITVIGWELQKIAKMLVFSESNYSNFDHKIGKQIVLLVNKRPRNPIAAKMFIRPNKQKQRISKENKLKTLTEFNNIFSNNKPISPAPEDSSSTQWFKLNRTSSLNIAKSAWKNHNKRYTGSTIQFASISHISLEEDDSKKIRRRNSISGDKPDGTEYEDVPFEIELDNELMRRNSFVSSYLKSRRKRAVFRQFSNDTIILEQDDSVDVTSPDVPNIIIRRTKRMRQQPNEHVKSFINNRLTDEIVEFNNVNEEFIDDQNITANLNYAEIEVVENDNVLELKIDKLPSISDLDWSAPINEITKLNNGTRDTIRNHNYKNLESPKVNSNFYFDSSPSNSATPHSNNCPMSPSYYSKVPLSPFVVNSRGKCFTPASTTFTDISEELPSSRQSTSSNYNILKTTSPSSSTSSHYSLTSMMHRTKPILNMLAPLAEPDDAENISKDVEKTLTNQNLNFTFDRKPSLEDIIEITETPYTNLSGILIEGWIKYLHYTNYQPNSIQKSQSGNDMSNFLSNNRLRNSARYKFIKGWAVLASINGVKYLLIYSNQKSEKANILIQPRYFKISLDIKLKTSKKHLLLLSNRSFEIYLATYTREDTLFWYDYLIKGNLINNEVNTIDEITQKYILQHSYYIRLNKNTVKSYNNNNNQYPPLLEVPSENESKNFLSSLIFKSKLLSRKTPNRASMNSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX48</accession>
    <name>A0A0N5BX48_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX48"/>
    <dbReference type="STRING" id="174720.A0A0N5BX48"/>
    <dbReference type="WBParaSite" id="SPAL_0001038400.1">
        <property type="protein sequence ID" value="SPAL_0001038400.1"/>
        <property type="gene ID" value="SPAL_0001038400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001038400.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24110" checksum="2259B13BAEEF51D7" modified="2015-12-09" version="1">MDQLTNRILNMAKVVEQQVDQQIAEYENLDDNGLEEIRRRRLAELKEQQKKKEEWLRNRHGEYEELSNENEFFEAAKASEKLVCHFYKPDVFRCKIVDKLLKTLATKYIGTRFVYVNCERVPFLVKRLKLQVVPTIGISINQKMVDYIRVSEELEDNGDIFLETLEERLSQSGVINKAPKIKAPKATTTKIIRGKLLKDGDSDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX58</accession>
    <name>A0A0N5BX58_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX58"/>
    <dbReference type="STRING" id="174720.A0A0N5BX58"/>
    <dbReference type="WBParaSite" id="SPAL_0001039300.1">
        <property type="protein sequence ID" value="SPAL_0001039300.1"/>
        <property type="gene ID" value="SPAL_0001039300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001039300.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26205" checksum="73B9350D0FCA2204" modified="2015-12-09" version="1">MFLVGLTGGIATGKSTISEYMKSLNIPVVDADVIAREIVKNGTSVHKKLRESFDSSFFNPETGELNREKMAEYVFRDIGARKLLNSITHPPIKRRIILEIIKAFFKGHQFLILDIPLLFESGMAKFVQKIVVVSCDGETQANRLMKRDNITRSEAANKINAQMPLRLKRERANFIVDNNGNVEETLEIVDELISRLRKSWLGLIIKLIIGIISILIVYKVYCIFETLMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX90</accession>
    <name>A0A0N5BX90_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX90"/>
    <dbReference type="STRING" id="174720.A0A0N5BX90"/>
    <dbReference type="WBParaSite" id="SPAL_0001042300.2">
        <property type="protein sequence ID" value="SPAL_0001042300.2"/>
        <property type="gene ID" value="SPAL_0001042300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46013:SF4">
        <property type="entry name" value="B-CELL RECEPTOR CD22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46013">
        <property type="entry name" value="VASCULAR CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895073" evidence="2">
        <location>
            <begin position="18"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="789"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="651"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001042300.2"/>
        </source>
    </evidence>
    <sequence length="828" mass="96709" checksum="66508C3BC34957E8" modified="2015-12-09" version="1">MFLIINLFFIITIFSLSINGNVLNDFNIFFKPSLEIRLMNISKEISLYGILFNQHINKLEHTYLIGNISKETLSTAIKQQGINITFNVQENYESKCMNKEKILTLQTYKCIPQFHGILIYVENLPINTKYIFEEISITYRRNNNSFGFINYKNHIFKVNKAINDGSGFINILGNDGILYQAYIRNPYLPYDKITVKNYIKEYNFSLLNIDYEKSSNIINFFGEVLNKIDTTISKYLIYLKEQRPLKVPVSNIKENVLVKRFSSGNRSIDFYFFKNDGVYYEIDCLFSKKKIPCNEIKNEIKIPFNRRNFPIGKQLQVDVNITTLLNGNLYNEVVKQLFIIFNDRPITTTSEVIYRNKIAIFECPDSGSEPIINKIWSFKKLKNGYAPEINNDIEEYNTKFYFKKMINHSLSYTSILYANSTDFQNFGHIQCTVVNEFGEGTIDYHVIELEKMKSHISFTVNSTEIYEGDAIMFNCTSFQNDKTSNLQIYAPSVNGPMTLLKSTSISPNQQIFIIENATPQHSGEYSCFQNTHDGYVIEEKVQIFVHQGEIVFPEGKNFNKNVNLGDNVILECPIIVQSYSFVQWSFINETTPDRTRRHIDEVDGNLFIQNNGSLKIQHMMMINVGQYIFEVHFDDHKEECNFRVYITFKDPEVRIKQKNDYVNMENKYILKQKEVIKVGEPLSITCLIEYESSLNVNVSLVKNNGISSMKLNNIIEDENNKVKRLTFYKKHASLTDNGEYLCMAKLFYFQKKVITTKTNIIVAKDEYDRNDIISKECNVKFPDIQTYKVLFFVFFISGILETLLLIGFIYIYISTTILYHRTRRPKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXL0</accession>
    <name>A0A0N5BXL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXL0"/>
    <dbReference type="WBParaSite" id="SPAL_0001053400.1">
        <property type="protein sequence ID" value="SPAL_0001053400.1"/>
        <property type="gene ID" value="SPAL_0001053400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="182"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001053400.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40840" checksum="5E43AB93515661BA" modified="2015-12-09" version="1">MGQTNSTRKNSYAVQNSQLTNFDFGFDVVHSDYDSYYGKIISIYSALDRATFENIFGEYFGKPLWDFYTTRSEMVEISKELFIRKTRLLFSSNYSIFLQIFPNIDELLKACFIGANIETSEDDIEIIKNIKEQMLLTKPGKDGKSGILIWIQRNCPRIFVPLQVKLINGIIGKKMVKHDFSSNLLTPLQMFLVKSSLNPITYLNVQGTNIFKENFINNWKPLYSSIKHGISVKRFENYVFDFKKPTISIFKLTNDQLCVLALDTEWEHNTTNYGSSFTTFISIKPSFYRIVQSNSLYSNFSIKTARKGIIYGDILSINEDFSNVAAIEAWGVEDESDIINREKEYDKQGSLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY16</accession>
    <name>A0A0N5BY16_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY16"/>
    <dbReference type="STRING" id="174720.A0A0N5BY16"/>
    <dbReference type="WBParaSite" id="SPAL_0001067700.1">
        <property type="protein sequence ID" value="SPAL_0001067700.1"/>
        <property type="gene ID" value="SPAL_0001067700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001067700.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41236" checksum="D04BB1EAC2E66B16" modified="2015-12-09" version="1">MIGLYYTFDELIVDLSQNAYDNNEMKSGMNDILVYLNKYCDKKKTSGSNGVALVTGTEGTIGKEVCKNLLSLNMKIICLTNFEENEKRKLLFSDNSSVTYISCDLANLKSVKNACKIVKGMIDSLDLVLCNAGVMCIKDKRDFNESDDNKIEKFYQANIESHSLINFISHAGIVKEMKELLRNSSLPQGGKVIFVSSSTCHAGKIPTLNEIDEGRFLTEYLNGYQAYANSKLYLSMYSLYLHNFSEIEVVDKPIEVKNDGKCNDIGKGKIEYLSLHPGVVAGNLYKHVNFIFQFAICHLLKVILRSPIVAAYYITEIALKPIFKLEGRYFENNYPVNIKGLSDNPGLIMNFGRKVDDILEDIGFNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY87</accession>
    <name>A0A0N5BY87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY87"/>
    <dbReference type="STRING" id="174720.A0A0N5BY87"/>
    <dbReference type="WBParaSite" id="SPAL_0001074800.1">
        <property type="protein sequence ID" value="SPAL_0001074800.1"/>
        <property type="gene ID" value="SPAL_0001074800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF35">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="148"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="152"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001074800.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56584" checksum="63874BB8D63B7DC8" modified="2015-12-09" version="1">MAPSRCAHELSSKKKIIRIEKLMAFCKKGTKEDLSSKLYEVWGDTQASITDIRLLFALGADPSSLFDENYGEYKLNERKENGTVCRSCATKYESFLEHSTSIYEAQFKSTPIKLDSKDNASSCASTNSTMTTSTNVSINVSDAKYIALSLDGGGMRGLVSVICLLFASRRIFGDESLVNFVNWTIGTSTGSLLALSLAKGHTLTEAFFNYWDVKNEIFLDKSTMARLFGNVVDKQTANVENVLERTFPSDTFTFKKYPKRLTVPALDISMTPAKLHIFRNYSYGNNDEFEDVTFKDAARASGAAPTYFHPHIMGNKKFVDGSLAANCPLNVLFKEYDRCLQNKQDCTLACIISIGTGEPEETNRRYKTGNSIKKRTQHLGHVTELLLEQVVGYEKSILECCEDRCRANNIPFFRINPTGISDRIDQIDNGKLTDMIWKTLLWLNNSRDLIDKLGVTLKEIYENKNENLTSSQLFFNENDILRENSPSLSNKFGRRKRSNTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYD0</accession>
    <name>A0A0N5BYD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYD0"/>
    <dbReference type="STRING" id="174720.A0A0N5BYD0"/>
    <dbReference type="WBParaSite" id="SPAL_0001079100.1">
        <property type="protein sequence ID" value="SPAL_0001079100.1"/>
        <property type="gene ID" value="SPAL_0001079100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001079100.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24221" checksum="CF2D789F11A6C9DC" modified="2015-12-09" version="1">MPVIPQYTLTYFDLMGKAEVTRMLFNYAGVKFTDKRVKFEDWPALKEKQPFGQLPVLEVDGKILFQSRAIEKFLARQFGLIGDDDFEAAQVDQYILSVDDVMNNLRPAFFEKDPTKKAELLKKLFEEHGVPGLKRFEGFLKKNGSGYFVGKKITLADFAVFQSLLYFKKLISESVLNDFPELEKFYDRVSKNEQLKPYLQTREEKLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYV2</accession>
    <name>A0A0N5BYV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYV2"/>
    <dbReference type="WBParaSite" id="SPAL_0001095000.2">
        <property type="protein sequence ID" value="SPAL_0001095000.2"/>
        <property type="gene ID" value="SPAL_0001095000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001095000.2"/>
        </source>
    </evidence>
    <sequence length="129" mass="15148" checksum="FA767164FEDEBA67" modified="2015-12-09" version="1">MNLIYSSLSLIINYVIYRIVVKRISVSNKAKMNDNKSIFWSIAIQSLFPFCYQVPAIIYYFVFLILQGKKVTEMEIFLNLLFYSRHFLSIFLSLIVIKHFKIMMLNDFGCKSITDSIPVTRVHAKSMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZC6</accession>
    <name>A0A0N5BZC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZC6"/>
    <dbReference type="WBParaSite" id="SPAL_0001111900.1">
        <property type="protein sequence ID" value="SPAL_0001111900.1"/>
        <property type="gene ID" value="SPAL_0001111900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001111900.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9665" checksum="B205C5F045784B62" modified="2015-12-09" version="1">MYFIIRYHNANEYYPLIYTCPIGSFFCLIFGYLLCDTTELVANEYSLRVIILVIHHLLFGMGCLYPLMKQKYGGLIVIGLLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD7</accession>
    <name>A0A0N5BZD7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZD7"/>
    <dbReference type="STRING" id="174720.A0A0N5BZD7"/>
    <dbReference type="WBParaSite" id="SPAL_0001112800.1">
        <property type="protein sequence ID" value="SPAL_0001112800.1"/>
        <property type="gene ID" value="SPAL_0001112800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733460" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="69"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001112800.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43902" checksum="979DEA1B302EB2CD" modified="2015-12-09" version="1">MFLRILLCLLGLSVVSQSEDDIFSERDKRSIEVRRSVKFSNPVRFYINNRKLNKLLIKKALVYLNNHTCLKFKEYTKELPSDGINFLLKDELAVFNDRYKEKLSFVHLTEKCSEELGCIKHMIGRAFGLQLETSRHDRDKYVTINWDRIDEKFKSLYQKEKGRNTRIFNTAFDYGSIMMPEISFGSKNGRNAYEVLKSPAYIHMVGQREEFSHNDLKKINDVYCKGLCARKFKGCKHGGYFSSDCGVCNCPPGYAGKTCTKIAKSVGYCGRKKRLFATESKRRLVLKGRKKCVIAIDTRAGRNVALVVEKVETEKLLPCVQNKGLEIKYRYDKGATGLVLCGSYRNISIPPTFSRTLLIYHGLENNHEVRISYREVKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZI1</accession>
    <name>A0A0N5BZI1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZI1"/>
    <dbReference type="STRING" id="174720.A0A0N5BZI1"/>
    <dbReference type="WBParaSite" id="SPAL_0001117100.1">
        <property type="protein sequence ID" value="SPAL_0001117100.1"/>
        <property type="gene ID" value="SPAL_0001117100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="355"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001117100.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70883" checksum="3B70168C4D477671" modified="2015-12-09" version="1">MSSTMERSKVKLRYLLGRIFSPNSNSDSDRSSETSLAEISGPYNTVHRIHVGYDGEKFVGLPESWMEILRRDISEADQKKNPKAVVTALKFYAAAYKGKQEDKFMMTKSVYPSEDDVEVVELDISSNELKDGYYDKMGNFIQTKTPENSLSEKGIKQNNDNMNYMTPTRDENLYTELTETLKKNKISNGKNKSTVVKPPIPPTRTQFHSVTSSLPTTPKENLSRNNGNLYAAPIVNKTKPPPLPPKPSQFKTVKQYSQDSYESSAFSNTTPSSVSNSSSLSSTKDDGTVDRKIEEIDVTGHNEPKPPPRAINEQVNDNINTPVRTRQQPKPKMTDSEVIEELRKMVNPIDPYTKYDLMVKIGVGASGTVYTARGKYNGKVVAVKRIAFKSQPKKEMLLTEIKVMEQYRHKNLVNYIESFLVDEDDLWVVMDYLEGGNLTDVCVKTELDEGQIAAVLKECLEALSFLHSHSIIHRDIKSDNVLLGMDGSVKLTDMGFCAQIAPGSKRTTMVGTPYWMAPEIISKTKYNFRVDIWSLGIMALEMVDGEPPYLREAPLKAIYLIAQNGKPEVKKKHQLSSEFNDFLDRCLVVNPDDRADTGELLAHPFIRKAKPLSSLVPYIKAVKDLIKSGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0J4</accession>
    <name>A0A0N5C0J4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0J4"/>
    <dbReference type="STRING" id="174720.A0A0N5C0J4"/>
    <dbReference type="WBParaSite" id="SPAL_0001152200.1">
        <property type="protein sequence ID" value="SPAL_0001152200.1"/>
        <property type="gene ID" value="SPAL_0001152200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF0">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001152200.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43763" checksum="857371D1337DA52B" modified="2015-12-09" version="1">MPKKFKLSSNNRSRSLVIVNSNNGDWRIDNKDNSRSNNIHFNESYHSGCREYGLSEFNINEANKSKKTSLVSKFCKTIQNIKNVVQGRSPSIIGIFKNNNDKQKNYNNEENDIAIPSAFNPSDEGNYERQLFHDMEAVENIAMISGNDNNLLNSILPGQDERSHINNNLDMISYDSDDEGRDEFTLRPRIPHSPEDHVLGTIKPCEQCSCCKIKDNYYAMVPDMDKIINATYYWGPLDRNEAEKILNDLPDGTFLLRDSTQLDYKFTASFRRFERTLHARIDFSNGFYTFDVMDNEVFKSPTVSGLIKHYNDPRNCLFFEPLLAMPKRRDFVFSLQTIAAATVASNIKYKNIAKLPIPGYLKDEVSSCRCLSSTFFQIHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Y6</accession>
    <name>A0A0N5C0Y6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polo kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Y6"/>
    <dbReference type="STRING" id="174720.A0A0N5C0Y6"/>
    <dbReference type="WBParaSite" id="SPAL_0001166500.1">
        <property type="protein sequence ID" value="SPAL_0001166500.1"/>
        <property type="gene ID" value="SPAL_0001166500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLO box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001166500.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10248" checksum="A9ADE804FA0E87B9" modified="2015-12-09" version="1">GAKLLEPALTRWIDFNDKYGLGYQLSDSSVGVNFKNNSHLVVVDGAMKNFQYVDKNSVREYYEYNKCPTMLGKNLSYLNTLKKLWKVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C188</accession>
    <name>A0A0N5C188_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Dephosphorylates translation initiation factor eIF2alpha. Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with lab-1; the interaction is direct. Interacts with knl-1; the interaction is direct.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C188"/>
    <dbReference type="STRING" id="174720.A0A0N5C188"/>
    <dbReference type="WBParaSite" id="SPAL_0001176600.1">
        <property type="protein sequence ID" value="SPAL_0001176600.1"/>
        <property type="gene ID" value="SPAL_0001176600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF510">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="13">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001176600.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37534" checksum="9A0CDFB3734821C5" modified="2015-12-09" version="1">MSAEGDLNVDGLITRLLEVRGSRPGKTVTMSEQEIKALCFKSREIFLSQPILLELEAPLKICGDIHGQYNDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFSIKLWKTFTDCFNCLPIAALIDEKIFCCHGGLSPDLQNMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVSGWGENDRGVSFTFGADIVAKFLGRHDLDLCVRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMTVDETLMCSFQILKPSEKKGKYQYSGMNSGRQVQSPQRGSAAPAGQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2T2</accession>
    <name>A0A0N5C2T2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2T2"/>
    <dbReference type="STRING" id="174720.A0A0N5C2T2"/>
    <dbReference type="WBParaSite" id="SPAL_0001229100.1">
        <property type="protein sequence ID" value="SPAL_0001229100.1"/>
        <property type="gene ID" value="SPAL_0001229100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF5">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895251" evidence="2">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001229100.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="34041" checksum="F0E96E09CFC790F7" modified="2015-12-09" version="1">MVSTKFFLIATQYFTSMAIAHCGNTIACTAAADCTSSTQKCMDIDGTNKACVEICNTDADCGDTAGSCAPTKTDDVGCNGGFNVCSIGVQQCLINADCSGIDPALPICNLYALICEADTTTSTTTTITTTTKNQATGGSNDCASLVAYCTNSLYFSLMKKKCSKTCGYCTTSSGSSGSSGSGSTSIGCADQVTSGSNSCDSMASYCTDTIYKYLMKEKCPKTCGYRTTSSSGSTSSTTRTDALSDCFSKSNLCTNTTYKDLMKQKCPKTCGYCTSSSSSSLSSSSGSTSTSTCKDAPYYCSSKSYLCTNTIYKDLMKTNCPSTCGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3T8</accession>
    <name>A0A0N5C3T8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3T8"/>
    <dbReference type="WBParaSite" id="SPAL_0001262400.1">
        <property type="protein sequence ID" value="SPAL_0001262400.1"/>
        <property type="gene ID" value="SPAL_0001262400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF6">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001262400.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52584" checksum="93C58EFB9FDE3AAA" modified="2015-12-09" version="1">MQLYVLDPVIDFTIHNISLLPSDQCATEDQRAAKCCCGTGFIFDFTKKKCIISENVSFMFGELNNSWSHLVIYGFVYPMLVVTMIAPLSAVMLGMGKREKKEGDKRFPNPLYQMIWLLSFCGWVSLLAPLPFSLWYYIIGDGIRSPNQSIFMCHLYRYTMQSIPHAVDTMMVLFSMLLTAARFLTQYHRNNLKLRTVERFARIIWTIIFCGVMIGILHHLEHDVAVYPFCLDAEEGPTWVHRCMLRDGSLYNFMGRRFWKITLPFAVLIFQFVIPGVMLSLIHLGFTREPVIDSSHCHNRFGRTPRDQTKILITTVTISFALAQVPTLIVSLFSLWVNQGISESKLVIFLGRLIGHLQPTFGAITILANLGALLTAYYIIVKDEDDDVGDSEADFSSCDSTEEKLLRLNDNRRNTKCYLTVSHSFDTSSMQSSSRRGSAMPEDYILTIGSTSSPGSRPTPMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C460</accession>
    <name>A0A0N5C460_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C460"/>
    <dbReference type="WBParaSite" id="SPAL_0001274450.1">
        <property type="protein sequence ID" value="SPAL_0001274450.1"/>
        <property type="gene ID" value="SPAL_0001274450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001274450.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22016" checksum="F5C1FFE778D66EBB" modified="2015-12-09" version="1">LKVIIFTAMKLFIAVGISISLSIIIFELFNFRKALFVMSIPILVILSTVIGIVKNLPKLIWPIIGISFFHFYLAANCLLIFLFYFIFKPLYIIMVFNWAFKTMHGGKTLSFYIYSFIIIISLIIILIFSSWQAKISLRYMNYMKLINERLYDQDNIKKVVHESGTQVLTIPVNCTNTQYVSNEIKRTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C522</accession>
    <name>A0A0N5C522_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C522"/>
    <dbReference type="WBParaSite" id="SPAL_0001304725.1">
        <property type="protein sequence ID" value="SPAL_0001304725.1"/>
        <property type="gene ID" value="SPAL_0001304725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001304725.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12636" checksum="763CE3EE7A976403" modified="2015-12-09" version="1">MYTALDEGGLRVDHGRTRINKILLGIGSNRINKYREINKYLGSSNFPKEVREIEKLCNIEINKIVGGFHTAPVTEIHEQKKCANTGARFYRIVNLSRQDLPIRLRVVGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5B6</accession>
    <name>A0A0N5C5B6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5B6"/>
    <dbReference type="STRING" id="174720.A0A0N5C5B6"/>
    <dbReference type="WBParaSite" id="SPAL_0001314500.1">
        <property type="protein sequence ID" value="SPAL_0001314500.1"/>
        <property type="gene ID" value="SPAL_0001314500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="22">
        <location>
            <begin position="390"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="20">
        <location>
            <begin position="560"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="21">
        <location>
            <begin position="867"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001314500.1"/>
        </source>
    </evidence>
    <sequence length="1222" mass="140227" checksum="8544CE67872E6EFC" modified="2015-12-09" version="1">MMEEVNLSNESNRKNNSKLTYQSKYDNYPASLFKQSKTPLTGVSLNDSDNTVLVPSDDGSTDSNGNYAEKRANVSSHDMGRQGTYHPKKKENKRGTAKISTTPNGPMIVEDPTEEKYKKKNKKGYGGGVIGCLLTLAVIASLTSALITHFVTLEQCPSSFPNKTIVLDDRFGPDFFKNTTILDDEEEKEETSIGEPTAEELRLPKNLKPIWYDLKLKVYLPGYVEIPKNKNLTFDSSIQIKFIVDEETNEIVLSADKLNFDSSDLENKYKLFKSDPSQDTNKTINVVRRRKIRSSDNETTEEFPLTTIKSIIEDDNSTEGAFPEPVSTSTLPTKNISLSESNDDISTPTIPTTTIESVEDKENIDGTTEIPTSKTTEKTLEQETVVEEGMSFSGINVIEVAVNETLKKVVFKLSDKLKKGEMYVFVIKYSGAINNLLGGLYLTKYTSNKKTVLAAVTQMEPDNARQLAACFDEPEFKAKWKVSVQHPTGTVAIGNGIELQEAIDTDDKDWKLSTFKETPPMSSYLLALVIGNFTYTEGKSKTGVRLRVWSRPDIVSQTKYALEAGIKVLEFYEDYFDEPFPLEKQDLIGLPDFAAGAMENWGLITYRETDLLYDPKVQFPFQKMRVSIVIAHEMSHQVFGNQITLKFWDDLWIQEGFAAYLEHIGSDAISDGNFRQDDYFVSDTLQYAMSIDAKATSHPLFFPITKAEDVEQAFDGITYDKGASFIRMLKNIVGEDNFKQGVREYINRHKYNNTVHGDLWDALQTTVPSDLKSWDGTPFEVAEFSNKWIEQMGYPVVYVRRIDESSVELLQKRFKLDENTIEDKKFRNAKYWYKWDIPIWYSIDGEEKNMTWLHESSTINTTLKNTLIINTDSKGFYRVNYDKFGWEAIIKQLNTDHTKISTKTRARIISDAFALAEANLLPYSVPLNITNYLVKETEYFPWHMAFSGLDKILNNFFDEPEVEVLEKYYAKLLKSIYESIDWDQLDSFLDDDKKIFENQLKSTIINIYCEVNRRDCVSKTLKLFRNNFVEACQDSEAVSSECSKVPVMIRRLVYCNGVKYGTDEDWEFIFDRLNNEVSQIEQKRLLVALGCTRSSVIKKKMLNDTISIDRNVYRLQDVSVIVDSLSSDPLGTRVSFEFLLDNWKRIQKSLKKLHSILNNFIDCSLQIRRQTDIQVFEEFLKKNKATTSKYDNFKQNLEVVKQKKEWRDKHMEHLVDWFNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5F1</accession>
    <name>A0A0N5C5F1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5F1"/>
    <dbReference type="STRING" id="174720.A0A0N5C5F1"/>
    <dbReference type="WBParaSite" id="SPAL_0001317900.3">
        <property type="protein sequence ID" value="SPAL_0001317900.3"/>
        <property type="gene ID" value="SPAL_0001317900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="77"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001317900.3"/>
        </source>
    </evidence>
    <sequence length="359" mass="41933" checksum="5251520CBDAF306F" modified="2015-12-09" version="1">MTFFMRSLILITLKLLFFITYLLIFTQRNYTENDIMYEEEGNFDDNQTGMFLIFMTIVIKNIVDFTEIANELKNDVSIFCLIHTSPKYKESRAIHLKNTWLKRCNDYLFVSTENDQTLPSIKGFRRDGYQFSNARMRKGLTYVYEKFGDKYDWIFKADDDTYAIMENIRMFVINRDPSEGHYYGFKLKIKDYYGHKIKYMSGGGYLISKGALKKLVTVAFKNPKICSPTPNIPDDVQIGRCFSNINITAMDSRDIYDRHVFLPSSFSEFGSLIESTHWNGFQKRSFYDLPKGMSALGNFPMSFHYAIGDMQYGLEYLLYHAEVAGRTSRIIQKTSSGNELNTEHALNMIKMYGKSNFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6H8</accession>
    <name>A0A0N5C6H8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6H8"/>
    <dbReference type="STRING" id="174720.A0A0N5C6H8"/>
    <dbReference type="WBParaSite" id="SPAL_0001354400.1">
        <property type="protein sequence ID" value="SPAL_0001354400.1"/>
        <property type="gene ID" value="SPAL_0001354400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895444" description="Abnormal cell migration protein 18-like fibronectin type I domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001354400.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40721" checksum="746A621E520A51AB" modified="2015-12-09" version="1">MKLYYYSSGTMFLLIIFVHIQHVRSEKAILQAGRITADALLTSTLNVTRHIESPIKALPLRDSKSRWGKSSCLSEDGTIRRHGEEFIPEGKEFWHACDNGNFKIIACRGSIKSGRARIPLDSTIYISGFWYKCIDRENGEVEYQEEPTCEIGNRHYHDGDFINTGGFRMICTRSGHAIIGCYYKDGNGTKISMNPGDRITYNGTVILCRQVRNKFFFQTMETGCRRDGKVYNNDEIWVKGNIVFKCEFGLINIVACQTGDGQRLSVGNRIVQDKHTLHTCTRESDRVVRYTMSTCGKPNFPACEPTAIEPPQINLETGDIKELNEHKEQLKEKLKIPSSDMRLIGAAGLRFLKSSVVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7B2</accession>
    <name>A0A0N5C7B2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xpo1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7B2"/>
    <dbReference type="STRING" id="174720.A0A0N5C7B2"/>
    <dbReference type="WBParaSite" id="SPAL_0001382600.1">
        <property type="protein sequence ID" value="SPAL_0001382600.1"/>
        <property type="gene ID" value="SPAL_0001382600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="106"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="307"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001382600.1"/>
        </source>
    </evidence>
    <sequence length="1128" mass="129172" checksum="73BBB06FEAEF7A7C" modified="2015-12-09" version="1">MSGQINEIIAAVKAIHDVSTPNDKRIEYTKAIETLKDSDPYTLIPLAFQLINIEDSVVQHVGWNILDHLIRYTWVRMPPELLIRMRDGVLEHMLQRQFTLDNQNSTVKTALVRSLVLMIEQEWPQNWPDLIDNLKNVICGETATPSQCYMIFLVLKRLVEDVVTLSTIENVTRRKDLYSSLVASVGDIISMTLFRIHKCISTNLNENVLLVKSALELISEIMEWVPIKSVNEKLSETIEACCLLLSCSSANVHEEAAKCLYRLVCKKRTKTDETSIVHELLKKTPVQAILTTANEAAIVGAASPEYYKFLKVLTDLLCELGLRITEIWKTLDSNDLDTFPTYLTALFALFNHPSLIIRSDISAVIVGIVLNPDIAKLPQFVQLMEINLTNFVKYMEKIGSISKNDNDITSHYNRMDYDNEIDFTRDFIQLRARCCRIVQTTITDYKDKYFNIMANWLQSRCLAVPQDITPTEWESFQKYIKTVVNSAYDKKIVDATTEESLTYIFDSVFRQLCTINDLKLANEIMSICSPLFNILRSHPDRIVPILNQCKHFLLLENNDLYEVKVIKRHVMIVMLRLVTMLSNTIQPYADNVYQVCCEAFSHVTIMQRGSLVQVLSALSNLCPNPNVKSEFLYNALKMNIEYIESDDFQKILQSPANFFEYVGFNVESVKDDDINSSVVIKNRITLKSNLFTIEGALQQVTVPENEVNPLYGILLPLIPKLFRFGNILNEMYDSKYASLIHPSYGEELLQISKDERRVLLTQITETDFTNQNPKDTYGPLEHAQLFISDLHDCVQSILGSCGSRLYISFYETPNCSEMLGSLVSNISNTPYNRLRFWVKRTWTPLLSKCPLSKLRVIGPMLFGVVEHLTKVLDKLWRDIENFDTSDDQSEDEVLMEHITCTLTRETISMYRLLFMTEAIAPNGKSGDESKKLTKELLDEKGLIILKEQQFLNNFIPNLMRILTCKDTQSAIRSLSICRIVVDTIKDISTEQIAKYLLTQALLAVQIHGSDEVAVGPILLYIYTIYSTFRPKFPDLYKVLAEVPECTEENLSSFDARVMNIVRANEQVVEKTKRDIVRKILKPIIATNIGQQHKRPAHLKQLPKIPVNIRGEMEKCAPDLNHSIFELWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8B3</accession>
    <name>A0A0N5C8B3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8B3"/>
    <dbReference type="STRING" id="174720.A0A0N5C8B3"/>
    <dbReference type="WBParaSite" id="SPAL_0001416400.1">
        <property type="protein sequence ID" value="SPAL_0001416400.1"/>
        <property type="gene ID" value="SPAL_0001416400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001416400.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19605" checksum="CD9FCB5A089BC1F3" modified="2015-12-09" version="1">MFFHLTLEHEISLHPKYFGPNLMDTVKQKLFNEVEGTCTGKHGFVIAVTTIDSIGHGMIQPGRGFVTYFVKYKAIVFRPFKNQVMDAIVTQINKVGIFCEIGPLSVFISQHCIPQDLKFDTINDIPCFKNDDETIVIKIDDEIRVKLIGTRVDASDIFAIGTLMDDYLGLVSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8V1</accession>
    <name>A0A0N5C8V1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8V1"/>
    <dbReference type="STRING" id="174720.A0A0N5C8V1"/>
    <dbReference type="WBParaSite" id="SPAL_0001433700.1">
        <property type="protein sequence ID" value="SPAL_0001433700.1"/>
        <property type="gene ID" value="SPAL_0001433700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001433700.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33185" checksum="8E1B0DB77E185B46" modified="2015-12-09" version="1">METVRVNKDEIQYLDLISNILENGKSREDRTGTGTLSIFGTQSRYNIRNGIMPLITTKKTFWKGIVEELLWFISGSTNAKELNARGVKIWDANGSRQFLDSLGFTERPEGDLGPVYGFQWRHFGAKYEGVDADYTGKGVDQLANVIDQIKNNPSSRRIILSAWNPSDLGEMVLPPCHTLVQFYVQDGELSCHLYQRSGDVGLGVPFNIASYSLLTHMIAKICGITTGDFVHTIGDAHIYKNHTDALKQQLTREPYPFPTIRFVGDNLNTIDDFTSENIILENYESHPLIKMSMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9H0</accession>
    <name>A0A0N5C9H0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9H0"/>
    <dbReference type="WBParaSite" id="SPAL_0001455400.1">
        <property type="protein sequence ID" value="SPAL_0001455400.1"/>
        <property type="gene ID" value="SPAL_0001455400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001455400.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14511" checksum="40366EF9DDAF2E41" modified="2015-12-09" version="1">MSKIICSICGSKSILFNNIPEFKEHVHTIHKCGGVTIGKLSFRCVQSFYRTLTSDNCNCKNTGIFTFTSILRHYQKMHNFGSPENNPLHEVISNTNEISINNDENLYDTENTSMDVDEMNANIEEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA69</accession>
    <name>A0A0N5CA69_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA69"/>
    <dbReference type="STRING" id="174720.A0A0N5CA69"/>
    <dbReference type="WBParaSite" id="SPAL_0001479300.1">
        <property type="protein sequence ID" value="SPAL_0001479300.1"/>
        <property type="gene ID" value="SPAL_0001479300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274:SF6">
        <property type="entry name" value="TYR_PHOSPHATASE_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001479300.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21480" checksum="D3DA9C04FEF6A671" modified="2015-12-09" version="1">MFSYIAFYPSLAYNILKNYAQPAKWPWYNRIDDGLILGALPFKSMVEDLKKENVGGVVCCTEPFELAISYNSMDGDDWTKENIKFHNVPMTDFIGTTSRKNIVDAVSFIEEVNNEGKSVYVHCKAGRTRSATIAMCYLVKKYDYVPNIAMEFLKKKRPQIILRNAHWRSVGEYRRYLDSQSKDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAW5</accession>
    <name>A0A0N5CAW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAW5"/>
    <dbReference type="WBParaSite" id="SPAL_0001503100.1">
        <property type="protein sequence ID" value="SPAL_0001503100.1"/>
        <property type="gene ID" value="SPAL_0001503100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001503100.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16403" checksum="7A46852F0EC87E38" modified="2015-12-09" version="1">MAIFGLTRLMYGGELFIEEDILKADPNSILNNLDKFTTLYDSKDVDYFISSGDPKMFRYILAYLNCLRHGFKTARILPSSVEELSRLSVECALLNLNGLKKMVEDMLSSYQSSEDNNYEKVYLKKVLEKSEHPSPLFHMNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB65</accession>
    <name>A0A0N5CB65_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB65"/>
    <dbReference type="STRING" id="174720.A0A0N5CB65"/>
    <dbReference type="WBParaSite" id="SPAL_0001512700.1">
        <property type="protein sequence ID" value="SPAL_0001512700.1"/>
        <property type="gene ID" value="SPAL_0001512700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001512700.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10033" checksum="509EEF8024F6F226" modified="2015-12-09" version="1">MDKKSEGNADASRQKYIRGHISSLHDAITEGVNVKGYTLWSLMDNFEWHEGYGTRFGLFHVDFTSPNKTRTPKDSVAVYRNIIKNNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBA3</accession>
    <name>A0A0N5CBA3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBA3"/>
    <dbReference type="STRING" id="174720.A0A0N5CBA3"/>
    <dbReference type="WBParaSite" id="SPAL_0001516600.1">
        <property type="protein sequence ID" value="SPAL_0001516600.1"/>
        <property type="gene ID" value="SPAL_0001516600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17082">
        <property type="entry name" value="RAWUL_PCGF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001516600.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60156" checksum="92161E8CD333BC78" modified="2015-12-09" version="1">MSCPKCPNKPFTNIQEAFRRDKSIQSIVYLVSPETYWEQLESKGEFLTKKLLSEEEQELIIEKDLVQFADQLVDENDKISITLEYLSDLANIQTSLIHSLKNEKIGNLTINIPEGKLKKEDSSKAFKRYFLVKAKTKISSLVELMELKFDLKKTEYEIVFTLITHPFVLNPELTIKDVIYISYFDRQNPLHMYFTILRKPREGSVEIVELDKEDEAAAPKDMPRLEKMDTIPLADEPPKLEKVNQSIPDVAANFSTQLLNGQQLSSTKQPGNNTLTSQNGKQNHGVKRKSALISSPPVSPPALVKESIDSNSNRNQKLNINSCNIMPTLQCNGIPTTTTGNQQQTQANILPNNKISLPTNFTMPNGVTAFNQFVSPGPGGQPRNSLPPNYVYTITNGIPNHVFNTPFIQTPYNMMNCNKISPTTKQQHGTSSLSVPNEPKPKKGRRSAESLSNNLVSQQIAQQQLFSSIFNGQGNNRPVFLQNDAGQIIGSNSNNIMIVHQSSNLLSATGIHPQHQQIKVLPTLAPKLNNKPVGKVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBP3</accession>
    <name>A0A0N5CBP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBP3"/>
    <dbReference type="WBParaSite" id="SPAL_0001530800.1">
        <property type="protein sequence ID" value="SPAL_0001530800.1"/>
        <property type="gene ID" value="SPAL_0001530800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001530800.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9395" checksum="DE366D403CAEA4F9" modified="2015-12-09" version="1">MNKEFMTILIVQAFTPVCLTGGPVVVVVILIMVQKVYVISFFINNVVHLLAFIPAVNGFLFTILLPSNRKLILSTLKKIMDTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBT4</accession>
    <name>A0A0N5CBT4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBT4"/>
    <dbReference type="STRING" id="174720.A0A0N5CBT4"/>
    <dbReference type="WBParaSite" id="SPAL_0001534800.1">
        <property type="protein sequence ID" value="SPAL_0001534800.1"/>
        <property type="gene ID" value="SPAL_0001534800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type_domA"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
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        <property type="entry name" value="P-type_ATPase_N"/>
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        <property type="entry name" value="P_typ_ATPase"/>
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        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
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    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
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    </dbReference>
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        <property type="entry name" value="HAD-like"/>
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    </dbReference>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="812"/>
            <end position="1039"/>
        </location>
    </feature>
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            <position position="419"/>
        </location>
    </feature>
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        <location>
            <position position="419"/>
        </location>
        <ligand>
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    </feature>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        </location>
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        </ligand>
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        <location>
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    <sequence length="1046" mass="118364" checksum="087D1DDE27B3E319" modified="2015-12-09" version="1">MARCIHGVMTTSDDSYLLPESSSSSPYQARLPVTTSRSCFRRFYESMFRCCRNMLRRKRSLHSRTLRLGYGPISGSHSNFVPNKVCNQKYNLFTFIPLVLFQQFKFFLNLYFLLMACTQFIPAIQIGAPITYWGPLGFVLTITLIREFFDDFARFLRDREMNGEKYEKLTRDGFVTIKSCQIQVGDLIMIHKDRRIPADVVLLRTSEKQGACFIRTDQLDGETDWKLRIAVPYTQNLTSDLELMNINCEVYAEKPQKDIHAFVGTFKVTNDDNTIHDCSLNVENVLWANTVLASGHAIGVVVYTGRETRSVMNTTLPDSKVGLLDMEVNNLTKILFLFVMVLSAVMVLMKGLDNNWYKYLIRFVLLFSYIIPISLRVNLDMAKLFYAWIVGRDKYIPNTVVRSSTITEEMGRVAYLLSDKTGTLTRNEMRFKKIHLGTVAFSTDSFSDVTKHVESAYRGTLGRHSFSVKLQTAVETIALCHNVTPIYENGTVSYQAASPDEVALVEWTEVVGVRLAERDLTSMTLQLNNGETRAFQILHLFPFTSESKRMGIIVKDQTTDEISFLMKGADTVMSKIVQYNDWLDEECSNMAREGLRTLVVAKKSLTPEQLADFEKQYHQAKMSLTDRNENMAAVVRKLETDLQLICLTGVEDRLQDEVTQSLELLRNAGIKVWMLTGDKLETAICIAKSSGLFSRTDNVHVFGQVQTRTEAHSELNALRRKSDVALVMTGASLNVCLQYYEAEVAELVCGCVAVVCCRCSPEQKAQIVNLLKKYKSPQRIAAIGDGGNDVSMIQAAHAGIGIDANEGKQASLAADFSITQFKHVCRLLLVHGRFCYKRSCALSQFVMHRGLIISTMQAIFSCVFYFASVSLFQGFLMVAYSTVYTMLPVFSLVVDQDLTAANALAYPELYKELRKGRSLSYKTFCIWVIISLYQGSVIMYGALILFDSDFIHIVSISFTALIFTELIMVGLTIHTWHWAMFVAQALSIFLYILSLLFMNNFFDPEFVQSVVFLTKSAVITAVSCLPLYFIKLLRRTFSPPSYAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCA7</accession>
    <name>A0A0N5CCA7_STREA</name>
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        <submittedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCA7"/>
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        <property type="gene ID" value="SPAL_0001551600"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="SPAL_0001551600.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="80684" checksum="80AC169E56202B9A" modified="2015-12-09" version="1">MVLSGEKSLKYRPDYEYNRVAETLLYQAQYAYDYYVHYMYNYLKKRKPLADEDSLKKASHIHAKRCADKVLKGLVAKDMAIKRSFSKQLYWYGSIHGSSNDYQQCEAINNQQKSNLDVYFHNSYLKQNWKYLPNGKYVYENTKFTSLVPICFADSLFLFDFCLLKPEGVSQRCGYLVETAADFNEEKCKLEPALKFTLHVPKNDLQEFNDLEEVYEAKETTNSGGKLTGAKVYYTPKEFDNDIQSIHTACCDKTYDYSFENDHISTKNYTIRQLDDYMKNDKNFLNDENTFYEKFTTDTIEKSPIIFKYRKTPKFNIFGEKDENENIEDKGNETISKAPFNAKVSYFQKITQDPINEGIKSENIFKEKLTEFESNSKVEVLKNDAKTNISFSNAWFNQENKKESDFLDSSSKKTKEHTNDYYFKSRNLSGPKPFKTTNTHLKQQQLTTKQLTKPQKEVLSNDDEFDDDFEISNIPPPLTFNHLEEVKKLREDVIIEKNKAPIENDKKVKMMVIKEDSKESSGILLSPSPCELGNQNRYNKKCNYCKVVSAPPTPMSTPNTLNRAFKETPKETPKGKYKKFNSVKSTTRCKEKYYYSNSISPIPCKSPKRNVNEKSRSLYNDNKKPQFDEESLLNELTSPRYKKTLNRDFLMATPKDKKKKSGKLFSNDRNIVGTIIKLLTPKSMQKTGKMVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCA9</accession>
    <name>A0A0N5CCA9_STREA</name>
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        <submittedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCA9"/>
    <dbReference type="WBParaSite" id="SPAL_0001551800.1">
        <property type="protein sequence ID" value="SPAL_0001551800.1"/>
        <property type="gene ID" value="SPAL_0001551800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001551800.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31225" checksum="A98934A4DD26AB53" modified="2015-12-09" version="1">MSLISNTSTPEEDDDDETYNLSEGTSTSQGDEEITSTEDESETSDSTQIDPLIAGKLKKYLKKYDLEYFKHSCSNKYIDLSNLPEVNPDSDDQLFYYEKCFVTKDEMDKLMASKVEEAKIQEDESSYEIMDSCDVMKKLANQDDCSTCHDDCKSCHDSHAKKWYNKLNVSSKNCDSQITDSESLTYKSRFKDKYYTSLYCHPYNLLKYGNDLFETYEKFEKDVQNSRIKRYRKILSDDGFEFVDDSMSIYKEKSGIKVKKNKKNKENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU7</accession>
    <name>A0A0N5CCU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU7"/>
    <dbReference type="STRING" id="174720.A0A0N5CCU7"/>
    <dbReference type="WBParaSite" id="SPAL_0001569700.1">
        <property type="protein sequence ID" value="SPAL_0001569700.1"/>
        <property type="gene ID" value="SPAL_0001569700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034518">
        <property type="term" value="C:RNA cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901190">
        <property type="term" value="P:regulation of formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22454">
        <property type="entry name" value="KH-I_Mextli_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040160">
        <property type="entry name" value="Mxt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569700.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61561" checksum="B629F71B7C10DD60" modified="2015-12-09" version="1">MKHQYHHSENGSNTMNSNTNDWNTVKFLPTTTTIHISSNGSGSSYSNHTSNRHSGNFQDIQQLSIDQLLIVMDHINTAVKNNEFTASLANNIFLLCQQLKLMGGMLEQTHKIYLNKVFISLRQACCRDAGQLGTPCRLKIMELIELRAMGWRPNLAHTQYYLNHQNKNESKDKMTTSVIGAPAAFNTIPVSAINFVPAATTTAAPLFVTGDQTASAGGTPQGFYIIPATNAIPSWGTAIQSQSMHQSTNDPETAAWTARNNLFNNCNMSKVFPNDGSFPVVHMRQKSNNKVPQIREEITIRNADSGKIMGVKGRRIAVVEELSKTVVSFQKVDSKSKDRILTITGTSHDSIEYAKKLIEETIRRNVSPSRELLENDESVSKDKNDSNIDNMGIKIETEADGTLRLSCSNPQYLTVAQNALTDYINRIGRSNRLSMDEKELRRERRKSMPLNMGGGGGGGQNDNNNASTNNRNSFHHCHNRGSFREKRSFAGSTPNLIEGVVGSSGTNQNNKISYTRKELQAIAEQNNTNNNEIDEPIARMINETIPEISRIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDY4</accession>
    <name>A0A0N5CDY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDY4"/>
    <dbReference type="WBParaSite" id="SPAL_0001607400.1">
        <property type="protein sequence ID" value="SPAL_0001607400.1"/>
        <property type="gene ID" value="SPAL_0001607400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001607400.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9072" checksum="C3CE9B694DC4E467" modified="2015-12-09" version="1">MPDGVLRIVSANKPQHQQHLGVQVSILWHLFCSYGWDFIEYSVPQVIQQPPPAAASAPDIGFILPPQQQKQVHNQSLPYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEX5</accession>
    <name>A0A0N5CEX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEX5"/>
    <dbReference type="WBParaSite" id="SPAL_0001641200.1">
        <property type="protein sequence ID" value="SPAL_0001641200.1"/>
        <property type="gene ID" value="SPAL_0001641200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895769" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001641200.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12916" checksum="231FCE6A7D778DB9" modified="2015-12-09" version="1">MILSKLNIFILFLYIIIPIWSIKNEEMHSNINDNFLQQHIRVKRRIGGLRIFWRLGRLGLRGVRRGGRMLRRRSCGGMYGYNNYNCYNNYYGNNYYGYNYYGNNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGH0</accession>
    <name>A0A0N5CGH0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGH0"/>
    <dbReference type="STRING" id="174720.A0A0N5CGH0"/>
    <dbReference type="WBParaSite" id="SPAL_0001694600.1">
        <property type="protein sequence ID" value="SPAL_0001694600.1"/>
        <property type="gene ID" value="SPAL_0001694600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001694600.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8031" checksum="4B2CC3B1F2F10C4A" modified="2015-12-09" version="1">MSALFNFQSLITVVLLLICTCAYIRGIFPKIMDRNKEGISGTFWKCARIGERLSLWIAGSCFIMAGFVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH79</accession>
    <name>A0A0N5CH79_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PINc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH79"/>
    <dbReference type="STRING" id="174720.A0A0N5CH79"/>
    <dbReference type="WBParaSite" id="SPAL_0001720050.1">
        <property type="protein sequence ID" value="SPAL_0001720050.1"/>
        <property type="gene ID" value="SPAL_0001720050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001720050.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17007" checksum="900C43EE53681426" modified="2015-12-09" version="1">MSKEERYESVRNSRYVDGVYRNSLPKITVDFIAYVVIPYAAPVKNDLTEVVSTSNVVLLLSQISSEVLKRWKNRSSEIIRGGLETILPSLASEETERNLSKGIWDSESFKIFVVDSEVSYRIHGYESRFQKFGKFVMSESRIPYGFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHN8</accession>
    <name>A0A0N5CHN8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="2 7">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="2 7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHN8"/>
    <dbReference type="STRING" id="174720.A0A0N5CHN8"/>
    <dbReference type="WBParaSite" id="SPAL_0001735200.1">
        <property type="protein sequence ID" value="SPAL_0001735200.1"/>
        <property type="gene ID" value="SPAL_0001735200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001735200.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13503" checksum="1711BBBA65AD0ABC" modified="2015-12-09" version="1">MKSKTPEEALEELRFSGMPQGSIFEILTHKVFTGNRPTNSIFLQKMTPLTLGALIALYEHKLFVQGVIWNIHSYDQWGIELEKQLAKIILKELNEPEDVSNHDSCTNRLINFVKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI78</accession>
    <name>A0A0N5CI78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI78"/>
    <dbReference type="WBParaSite" id="SPAL_0001753700.1">
        <property type="protein sequence ID" value="SPAL_0001753700.1"/>
        <property type="gene ID" value="SPAL_0001753700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001753700.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10187" checksum="C1C8094C4BCFD4D9" modified="2015-12-09" version="1">MGNLKPTKSLLLYTVQNPEGKFSCIYKVPICEIEKSQNYKLISNKTYPDVEYPFNGPKYEANCSRHLNSFTHLRGIQFKDDKTIIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIV1</accession>
    <name>A0A0N5CIV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIV1"/>
    <dbReference type="STRING" id="174720.A0A0N5CIV1"/>
    <dbReference type="WBParaSite" id="SPAL_0001775600.1">
        <property type="protein sequence ID" value="SPAL_0001775600.1"/>
        <property type="gene ID" value="SPAL_0001775600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="49"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001775600.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15891" checksum="25D868CA53567A92" modified="2015-12-09" version="1">MQLNTTSVNYTDYETQFVKNFTHRRKHFLDNPDKTHDLCLLPRAIFNKKQWYKILLPILMHGDDPHLYYNMVSFMYKGKRLERLLGSLRFLSILITFIIATPLVHILLSYAGDEFFDMGRFMRECIVGFSVCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CJ09</accession>
    <name>A0A0N5CJ09_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CJ09"/>
    <dbReference type="WBParaSite" id="SPAL_0001782000.1">
        <property type="protein sequence ID" value="SPAL_0001782000.1"/>
        <property type="gene ID" value="SPAL_0001782000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001782000.1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6271" checksum="C6717463EACA5525" modified="2015-12-09" version="1">MKEVVKPNKFDLGNSCINQEYVDELLQLGFIRLAENEPSYVAPIFLVDKKTGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1V1</accession>
    <name>A0A0N5B1V1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enoyl-CoA delta isomerase 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1V1"/>
    <dbReference type="STRING" id="174720.A0A0N5B1V1"/>
    <dbReference type="WBParaSite" id="SPAL_0000005200.1">
        <property type="protein sequence ID" value="SPAL_0000005200.1"/>
        <property type="gene ID" value="SPAL_0000005200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000005200.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36946" checksum="8E95E639F596440D" modified="2015-12-09" version="1">MVFIKPLLRLGFTYSKKFSVTYARSISSGNKIYTGPIKNPLYLQNWLDDYCKLQAYHNINDIYNYELLRSQLKDTDDDEFDFAVDLPNMKIERMSKAVVIKIEDSNNENTSIMDMYVGLTEALNYSLEDRASSITVITGKGQFFSNNNDISKKNLDDVDKFISVYMKFMHSLIDHDKPLIGLIKGPTVGIMAELLPLFDYVLASNDATFKTLAFENGFMPGGCSTFTFPALIGKQTSFDFLWKGRSITAMKAKSLGLVNAVVHNYYFEQIAKKKIRQFSKLDPTSLIVGKKLFRDNVREDLYKCLDVEKTSKRLLKTDDKLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B201</accession>
    <name>A0A0N5B201_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B201"/>
    <dbReference type="STRING" id="174720.A0A0N5B201"/>
    <dbReference type="WBParaSite" id="SPAL_0000010400.1">
        <property type="protein sequence ID" value="SPAL_0000010400.1"/>
        <property type="gene ID" value="SPAL_0000010400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000010400.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42757" checksum="2A65DEB482368B05" modified="2015-12-09" version="1">MSSTPLFTTHANFAIKTLTKLIESNKEPKSIIYSPISVGIALAMAYVGSCGEAKEQIKKHLVGDLDDEELHSKFNEFLNNISKNEEFSLECVNKIYVKDGFSLSDTYTQTIMKYYNGQFEQINFTDPNSCDKINDFVKKATNNIIENLISQSDLDELTRLILINAIYFKGKWCVKFDKSNTIEENFYVTKDVTKKVKMMTKKDKYQYCENEDYQILKLDYEGRQHSMIILLPKEKCSLIEKLPSLDGQLLFDLQSKFARNVPVTVYLPKFKTESTHILNEPLISLGMDVPFSGKADFSLMSNEEPLKISKVIQKAFIEVDEEGVEAAAATAIIMCRITCIPSAPLKEHIFRADHPFIYFILDNHNNILFSGIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2R2</accession>
    <name>A0A0N5B2R2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2R2"/>
    <dbReference type="WBParaSite" id="SPAL_0000036575.1">
        <property type="protein sequence ID" value="SPAL_0000036575.1"/>
        <property type="gene ID" value="SPAL_0000036575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000036575.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11933" checksum="A7C59153886DC88B" modified="2015-12-09" version="1">MLTRSQKKLPITKTSFETEEEVFQRIILSAQGKETMSGTQTGTDTDTGTSTSILSENTSIDDQITLLNMMMKSMQMMHNSSLDRSKNSTISNSFNLEKFSTESFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Q4</accession>
    <name>A0A0N5B3Q4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sodium channel protein Nach</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Q4"/>
    <dbReference type="WBParaSite" id="SPAL_0000070700.1">
        <property type="protein sequence ID" value="SPAL_0000070700.1"/>
        <property type="gene ID" value="SPAL_0000070700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF1">
        <property type="entry name" value="DEGENERIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000070700.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="56234" checksum="9C73B3AD11CE48BF" modified="2015-12-09" version="1">MEKKNVKDDNRYSFKSKREFLRKTLSEDYPGLDYLGIHNVLHAKAFWYKLLWLFVLLVCFILGIYTVFAVIKEYHGKPSSTKISVHSVHELLLPQITICPTNPMTLNLQKMANGLFIKNNISTWNTSTVEDFANFMLLGSGFHKVNLDFLESVNITEMTYLYDTFRNNVTVLEYFSEFFDTYGLQCSQFFKSCSLGSQKLDCCKIMTPTYTIRRGRCFRTIELKQKTFDELGKLKLEIRKPKFMFNETKNVEIIAFVGEHKESLAPFPRYYISEGIWIKMRIFAKYINLIERDGVCTDQVNSISKASCYLRDWMKTKVEDPLNCTFPFVSLSKEVDLDGCRPDALAKVYRNIDDANYITHDCILPCDRWEYTVVNEAPKSLLNMDKPTKLDYSYRLDVSYNDLQYEVIEEVLTMSFTTLIALVGGQFSLFLGSSLLNFIQAIIMIIILSKRLIKVSRRKLQLMRRPQISTPECSITLKDIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3W5</accession>
    <name>A0A0N5B3W5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3W5"/>
    <dbReference type="STRING" id="174720.A0A0N5B3W5"/>
    <dbReference type="WBParaSite" id="SPAL_0000076500.1">
        <property type="protein sequence ID" value="SPAL_0000076500.1"/>
        <property type="gene ID" value="SPAL_0000076500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF12">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000076500.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38860" checksum="DE934738DCE57E75" modified="2015-12-09" version="1">MIPFLEKDIHALYNDGLIFCIHISKLQKQMIFEGISRKLQKDIRIFCVILTSPKFKFSKCISQKATWLKRCNGYVFASSEDDPTLPSIKAFPQDNYNYSFGKVKNGLRWVWKNQKNEYDYVLKADDDTYIVMENLRAFLLNENPDDHSYLGFTIYNPPGNITNGYIQGGSGYVFSRKTFNTLVENGLSNKKYCTQRDDAFDDLEIGRCLFRMGIFPTFLSDDRNRFVFNPELIPSVLARKKNVMNFYTVYSLFQPKRGMNSFADFPIAFHRIYSDLMYFLEYLFYHARVIGTNSRLFRMEDNDQDDRNKKIQKRMKLIKAFSKYNYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4H5</accession>
    <name>A0A0N5B4H5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4H5"/>
    <dbReference type="WBParaSite" id="SPAL_0000097700.1">
        <property type="protein sequence ID" value="SPAL_0000097700.1"/>
        <property type="gene ID" value="SPAL_0000097700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="61"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000097700.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34971" checksum="ADCAAD916EAB142A" modified="2015-12-09" version="1">MNIVLKKSPSVHYKLPSNSEIVPIEKNDKRLGGNEELVNAEKVFLGEKCGNNEISRKFSPNKVILCVKDKAFVLDKDFLANISPLFKIIINSSSTIKSKCCIEKEIVDEKPSDIDIFIKCLEEPKNITYDNVALIMRLATKYVIPSLKESCSNFIRNIDIKEMSLPVIVEFLKNCLKSMTFDRRFEKLILRIAMEDSIKIQGLKLTHIHHKLYGSVMATHFNVLYMKAVENMNGHFFNLEKNKIKYNKYICKGCNKIADVVFCIGCKKDLCENHWREKRCENNYGSMELRKIKENLVDISKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4X1</accession>
    <name>A0A0N5B4X1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Programmed cell death protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDCD4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4X1"/>
    <dbReference type="STRING" id="174720.A0A0N5B4X1"/>
    <dbReference type="WBParaSite" id="SPAL_0000112100.1">
        <property type="protein sequence ID" value="SPAL_0000112100.1"/>
        <property type="gene ID" value="SPAL_0000112100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039778">
        <property type="entry name" value="PDCD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626">
        <property type="entry name" value="PROGRAMMED CELL DEATH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="299"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000112100.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47579" checksum="8ABA28F79E159D26" modified="2015-12-09" version="1">MNYSRSRCNSERFDDPEVLAELQFAKENNLEYTFDIEQTTNGGGKRSRNNSFRSVEKITNTKSPIKPKLSKSSSKAEKKARARGISGCSIKKSKSFSDEYDSYCSDDFDNETSEEDFSDGNDDYEYYRKDSQHHCISAAVADYFTSLELEPAVGELISFLTNEQDIFFVFNKIVTYPLESGDHGLYNAVSSLLIALLESDPSQQNERLEILTRVIEDVLLNIKEWMLDCPKTIDVFGTLLAQFVLDGIFERSFLTTIRAKVSIIDDAENCTIKAIELTEKPDMILKVLPCDGGLRPIDSLTEDICKILKHLLHDDTIDECRKKLLALNAPMYKHEIVYQAALLSANENDKTTTCLLGDLITSMFNNKEITQYYIDTGIRRFFNDIDNKIIKVCKNEVDGFVDILRQNTNIKSDGIISCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Z8</accession>
    <name>A0A0N5B5Z8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Z8"/>
    <dbReference type="STRING" id="174720.A0A0N5B5Z8"/>
    <dbReference type="WBParaSite" id="SPAL_0000148900.1">
        <property type="protein sequence ID" value="SPAL_0000148900.1"/>
        <property type="gene ID" value="SPAL_0000148900"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000791800.1">
        <property type="protein sequence ID" value="SPAL_0000791800.1"/>
        <property type="gene ID" value="SPAL_0000791800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000148900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000791800.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14944" checksum="653DCD7E79F7DB07" modified="2015-12-09" version="1">MSKMDFRPIYLYEFKLGQAAAKTSRKVNKAFGQRSTNKRTIQCWFQKFSNEDISLQSQENFHGINILENEKIKRILEHNPRITVREITGELNVSVGTVSNHLKPINMKKKDSYILREYTPDQCFRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6D5</accession>
    <name>A0A0N5B6D5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Required for correct subcellular localization of pgl-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6D5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6D5"/>
    <dbReference type="WBParaSite" id="SPAL_0000162500.2">
        <property type="protein sequence ID" value="SPAL_0000162500.2"/>
        <property type="gene ID" value="SPAL_0000162500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000162500.2"/>
        </source>
    </evidence>
    <sequence length="556" mass="61309" checksum="50E06663594F81DE" modified="2015-12-09" version="1">MKVPRSGFRTMFKEGTQYFEGVEETVLRNIDAVNELSGKLKTSFGPNGTNKMVINHLEKLFVTKDAATMLHEMEVIHPAAKLVVMASEMQEQQIGDNTNYVVILSSALLVEAAKLFEYGLSMTQIVEGFENALKVVEDVLPGLSVKTVTDLSNMDDIRKALKASITSKQYDNEELITDLVSQACIQTLPKNSFNFNVDNIRIVKILGSGVHDSKVVNGMVFHRKTEGEITKADNCRVAVFACPFDVMHTETKGTILMNNAEDLLNFSKDEEALIEKQVKELADAGVNVVVAAGKFGDLHIHFLNKYKIMGVRLVSKFDLRRLCKQFGAQAQARICCPPLASLGQCDKAFVTEIGAASVVVFSKDSESGNISTIVVRASSKPKMDDIERALDDAINTYKCLSKDARLLAGAGASEIALARAIREKAHEAARIDREKKLNKIEHYCYENYANAFESIPRQFMENLGLNPVEIIAKVYKAHEDGNSNTGLNVFTGELMDAVKENIYDPYLGKLSAIRLATEVTLKILQIDQIIMAKRAGGPKPRGPKPQDDDDDFGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6R3</accession>
    <name>A0A0N5B6R3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ING domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6R3"/>
    <dbReference type="WBParaSite" id="SPAL_0000174900.1">
        <property type="protein sequence ID" value="SPAL_0000174900.1"/>
        <property type="gene ID" value="SPAL_0000174900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000174900.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13163" checksum="E766A92BC523001C" modified="2015-12-09" version="1">MSTIKHPEDLIDEIVQMINEYETYADKNNQKIVAYEQNYRIMLQNVMEKNEIDETSCREIKNCLNRLLHTTTQISLERIKLVEIEEKINKIIYETNSKKRSKKKKNSDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6X3</accession>
    <name>A0A0N5B6X3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6X3"/>
    <dbReference type="WBParaSite" id="SPAL_0000181000.1">
        <property type="protein sequence ID" value="SPAL_0000181000.1"/>
        <property type="gene ID" value="SPAL_0000181000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000181000.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10427" checksum="9C3A102F93D4D801" modified="2015-12-09" version="1">MYKIIVIKLFANKENLNFIWWDKFITFYANLCPFFFCVYTHKIIFGLDFKKFKILDCSKNKIAFTGKIKKIKETLLFEQPKKLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7U8</accession>
    <name>A0A0N5B7U8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7U8"/>
    <dbReference type="STRING" id="174720.A0A0N5B7U8"/>
    <dbReference type="WBParaSite" id="SPAL_0000212300.1">
        <property type="protein sequence ID" value="SPAL_0000212300.1"/>
        <property type="gene ID" value="SPAL_0000212300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000212300.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14452" checksum="61682120C0B0056F" modified="2015-12-09" version="1">MGRISGWENKRKHLQQSMILVTMDTPGVPIVRPLIVLGGVFTMEINPTDNEVFDESRSQNVPKAATVVVNTINYLHKRKGCSEICSFQSKSASRDYLEDESLKEYHFIKNKFEKRREILQIISPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B967</accession>
    <name>A0A0N5B967_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B967"/>
    <dbReference type="WBParaSite" id="SPAL_0000258400.2">
        <property type="protein sequence ID" value="SPAL_0000258400.2"/>
        <property type="gene ID" value="SPAL_0000258400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894119" evidence="2">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000258400.2"/>
        </source>
    </evidence>
    <sequence length="373" mass="43368" checksum="68DA58B52FFF4A88" modified="2015-12-09" version="1">MMIINLILIILFLQLVYGEERENTNLQICLKGWQNPILTIPTLSSPSIPLKCYPDDRICEKYGAECQFSLKSFEYICCKDNDNLRIPICPRYYDTLHTLCGKSGNGGNCPKSYECMKARNYPNLELCCRRNNDLRYVEPETTFNDHFIVPDILPYAPKETIDITFGEDILTEGQLISREQINDLLERPPLLSGYVFSDNLQYTVIIIGFPFRFTKNTAIDYPSTVYLFENDIKPLKGEIILQEINEIGNKQNYYNRKSLKEIENSLKFSKCCTVPYKKPGNEIKSKGLYALFIYHIFFLEIYTMVLVVLRQKKTFTTSQQNIFVKRTSKDRGSNKNDFISPTDEPFYMKKFLKQYKDIFDEVPVAGNFYGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAR0</accession>
    <name>A0A0N5BAR0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA-binding domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAR0"/>
    <dbReference type="STRING" id="174720.A0A0N5BAR0"/>
    <dbReference type="WBParaSite" id="SPAL_0000312500.1">
        <property type="protein sequence ID" value="SPAL_0000312500.1"/>
        <property type="gene ID" value="SPAL_0000312500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000312500.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34070" checksum="3D6E711A30F850AA" modified="2015-12-09" version="1">MLAVHMVAFFDWSYGLSIEETNLENEVVDSILEKKFEKACKILPSLTDKISRKDILYFYGRFKVATEGRPQIKEMPSIFDMKGNAKFSAWVNAYKSCLSKSKAMKEYVDMLESITGINISESTHFNNTTSAIDMKPSRMLYEEEELDENADENEKMLYEWKKILEENDIEAVEKLLDSDKKDQLLNLWDESLGMGVLHLAADSGRTIICGLLCLNGVDVNKRDADGQTPMHIAIECDHEDVATILARHGPNLDIKNNEGKSVYDLLEEKNLRDLTMTIEKIMFSEMKEEDQFKFDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB10</accession>
    <name>A0A0N5BB10_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB10"/>
    <dbReference type="WBParaSite" id="SPAL_0000322400.1">
        <property type="protein sequence ID" value="SPAL_0000322400.1"/>
        <property type="gene ID" value="SPAL_0000322400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF10">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000322400.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="27512" checksum="F656F78B55DF3789" modified="2015-12-09" version="1">MLSNFIVWKNFSILYCKEDDILPDILETFYGKGIQINQLLLLDESLNKTLSEMFGKKNWKFLSIIEHPIERFFRKFIHYCVNGNNSKETQNCYGCKDNLECLLTVIFKVSTEYTKKEPIFKPTYFDEIFMPYSWKCNFYNDLSDYEKIIYYDKVKFKNQITKLLNDTNVIIKNNNTFDTLIEKAHEKNTENGIKKYQEMLLNDRRMLFKFVTVYFHDFLRYGIEMPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB40</accession>
    <name>A0A0N5BB40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB40"/>
    <dbReference type="STRING" id="174720.A0A0N5BB40"/>
    <dbReference type="ESTHER" id="strea-a0a0n5bb40">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000325200.1">
        <property type="protein sequence ID" value="SPAL_0000325200.1"/>
        <property type="gene ID" value="SPAL_0000325200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894244" evidence="6">
        <location>
            <begin position="17"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="28"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000325200.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="67370" checksum="A431B8A97324374C" modified="2015-12-09" version="1">MKLFFILLFSITRTLCYDGPTIQMGENAFLQGKSITVLGEKITEYLGVPYAHPPLDFYRFEPPAEFDKTYWKSTYNAVHLADACPQIIRKMGFKGYDDANPKNSRESCLKFNMWVPTSNDGKNMPVIVFFHGGSWTVRTASVDKFNGSVLALKTNSIVIAANFRLGFFGFAFLKNSSKIRGNMGLLDQQAMLKWIHKHIDKFNGNRNSVTIFGTSSGASSVAAHLFSEGSKPYFHRGIMSSGTITHFMSTVSADIADINTRNVSRMVKCIKDNNEKILADDDIADCLKKKTIKELLDAARKVRASGQFPTPFPFMPIDTDSVFFNGSIKEMYNKQLFNKEVDLMMGRTADEATFFMATGFTNNSRYNCNFYPQLSATDPKNACIMNKEDFLNLVDLGAGIMKFNSTEKQQLIKIYDESATTYTNRSIRILSDFIFDCELSRFANIYANVTSKNVYLYEYARRSPINVWPPWTGAMHGDDLINIFGIPFRQPEKYKYKDSKEKNADCIDNIEEEQKYSEKVMWAIGNFSKSGQIETGWEKANSSNLKAFIFNGTSSFEKKEHKNFRPKTCDKLSNLIIQSIKRKMEEMKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB91</accession>
    <name>A0A0N5BB91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mnd1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB91"/>
    <dbReference type="STRING" id="174720.A0A0N5BB91"/>
    <dbReference type="WBParaSite" id="SPAL_0000330100.2">
        <property type="protein sequence ID" value="SPAL_0000330100.2"/>
        <property type="gene ID" value="SPAL_0000330100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000330100.2"/>
        </source>
    </evidence>
    <sequence length="376" mass="43368" checksum="B95240F060170E51" modified="2015-12-09" version="1">MSENRCTGRASKRNMPSRKGNYSSIDSHNSHDLNYGKQELLDNLKIFFEKNDYNSMEDIVIELIEERNKLSRKLEAINASDLGESKCMPKFTCEFSEIFDKVNSLSMEKYFLEMENKRLQGEVKELHDLNIKRLEPLLEKAIKCPHCHSTFKYSFDEDERFNSERFERMSKTFNKGINTSTGNICYIPVMENGQMTTTKKSSIDEDINDGKRVTEEWLKKIKHSQKSTKPYHMLISDRQRKNRNIKMLKAMYKANAGNKIDPETIDYIISETGYEGQLKFTISIEELSPIIMHHKFSNRGLFALKALIDGKAGWKVFPTRQQIAGVRADTSENPLNSKLSSPVDDDQAEFSKTSKDLTDESNESSKTVETIKNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBB3</accession>
    <name>A0A0N5BBB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BBB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000332300.1">
        <property type="protein sequence ID" value="SPAL_0000332300.1"/>
        <property type="gene ID" value="SPAL_0000332300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="646"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000332300.1"/>
        </source>
    </evidence>
    <sequence length="1045" mass="120467" checksum="A2E8F86DBBA2A273" modified="2015-12-09" version="1">XTSMRDGNRITKSVEYDEIIRRARRTARGEESSTSDDVIDDVDNPGVYSSGNDDVKYDESIGRRSTNDDDCVVMTQPLSHVSPLPQNVVMTGQPNSRRDYHMNAQVFAGFERIYFKEDMVPRPTIPRFPMYIPNVMSVNDDVNSQRGERVKSKVNDNQNLKKKESKFGKYYPINIPDEDDERRYSNREGYSDEFSNFSQYNVNYQPQYPPYAAPVYNVVPSCNVKIDAYDPKEDFSLFLERFERRVASDIQKQPYIKSNYGELIRYLKENYKGEESLAAARQKLMNLKLNRSSELVTVGAEISRLIDVVYSGESHRERLRRKRNHLAECLPAGLMRSLIKHDRPEDEPFDHTILVAKDYWDDINASSKSKRSEGARDKFQGECNFCKKRGHKEVDCRLKKKKDKSLKEVNQSEKVSKMVKGEVKESNSADSVRGEVNLEKPGSDLPIIQVKVNGCDSIKMLVDTGSEITILPMRFRSECAIDEENKLKIRTLNDHGAITSYRTKEEVKFNIGDKIINCFAYLCAVDFTNRAYEGILGWNVFKQLVVTFDDKNEKIVFREFDKPDESNIAEINVSIIDEVDKSHEKVVKLKVEFADIIAKNEYDLGSGKIKCHNIVLKDNCEFPRPATIPIQEVDKPILKEYLDNLEASGVIVRKPSPYAMPIFMLKKSDGRRRIIGDMRSINAIVQPIYYSPPLVPNAILKMRNCSYFTKLDCNNAYFQVGVPEESQVYLAVKTPFGTYRFRRMVQGFINSSSEYQRIGEEILHGLEEYCTNYIDDIVVHTAGSLEFHVSKVKEVLLRIRDADFRISFEKCSFFGKSIKYLGFHINVDGSVPHDSNIKAFLKRPFPESKKSLKSLIASANYYRNYIENFSDLTYHLDELLKKKYRKLVWNDVAKQSYHKLIQAMSSPKFCHHPVLEEDFILTTDSSDHSVGGVLSQMRNGKEVPISFYSKRLTPTKRKRCITYKELMAISRCFRHFKHYFGGSRIHIRTDHLPLIGIFKNSVDNRYLELTNDLAGFDFKVHYVKGSSNVVSDDLSKEVYDPKDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBR3</accession>
    <name>A0A0N5BBR3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNAse P Rpr2/Rpp21/SNM1 subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBR3"/>
    <dbReference type="WBParaSite" id="SPAL_0000346900.1">
        <property type="protein sequence ID" value="SPAL_0000346900.1"/>
        <property type="gene ID" value="SPAL_0000346900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000346900.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21521" checksum="CF3B24E22D68A1DE" modified="2015-12-09" version="1">MFSVFNEITIDESIDDARKKTLGFLRNLSNTKVLPPMLRSQVANEARNLSKDVFGTHKNSAKKFHCEKCNVILNSDMVKVKIAKRNKKKICEMTCKGCGSVFYFDFNARPKNGKCSEIKMEAKKDIKNTTLVLPKPQLVVKTKPKVNNVKPIVSNVKPKKKLTKLQMMLQQQAEADNSSNLSTFFDSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCW7</accession>
    <name>A0A0N5BCW7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Str_synth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCW7"/>
    <dbReference type="STRING" id="174720.A0A0N5BCW7"/>
    <dbReference type="WBParaSite" id="SPAL_0000386200.1">
        <property type="protein sequence ID" value="SPAL_0000386200.1"/>
        <property type="gene ID" value="SPAL_0000386200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF124">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE CONSERVED REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="4">
        <location>
            <begin position="204"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000386200.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48229" checksum="38ED412E6FCA856D" modified="2015-12-09" version="1">MSKKTRSYNTKDIKKPSAKELFSKLRLTRRAVIQSITFSLILSLSISFFFNLGPTNPQSYRQVLKHKISKKIEIKNLECKNRIVSDYIKGPESLLYNKERNSIFSGSRNGSIVELDIDTLKIKKVYSIFNNNKKINCDGSSYTLPKCGRPLGIHFGVTSTTRNTLYVADGIFGIYSLDLNSQKITVIEDSREREGNNKKMYGNDLVVTKTGIYFSISSTKFDDHEYLYDVLEHSNNGKIMFYDFETKRISEIMKDLYFPNGIQFIENKEILLVGEMTKMRIIKIDLKKEKAVSEKFIEYLPGYVDNIRVIQKDNVKQLIVPIPEQVTDNDEIFANYSGLRRMLTSIFQYPIIEKIISFLSNDNSIFQYYDIDTGEYLETYSVPFKGLSISHVLHLQNLNTFYFGSDNGNHIYACQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD30</accession>
    <name>A0A0N5BD30_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD30"/>
    <dbReference type="WBParaSite" id="SPAL_0000392100.1">
        <property type="protein sequence ID" value="SPAL_0000392100.1"/>
        <property type="gene ID" value="SPAL_0000392100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="301"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000392100.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50331" checksum="2804EE53CD13CFE4" modified="2015-12-09" version="1">MRYYILFLPSISILLPQNPPTMPSKRGSYVKKISPPLLPAKQYNYVMPNEHEVIRPQSIVHYEVKLYHSKIGSIFYECNGVTFPNQLQAEKYCLMLNNYELKKAKQNQQHRTSINKNHRNSLLRSNSDLSNKKKPILRVSGSLTERKHSSSGSRNSLLGLSRSSSSQSLAESSKHLTLVRNDVSGSNNGLSSRRGSAFGSNNDLSSGGDSGFGSTKDLSSRRNSISGSTNDLSGKRRSSSLERRNSLSSSREILKNKVIDNEIYEESFDKNIKKKSKSYQIWLKVWKNCNFKCISENYYDGYRQHALLEMNMYRLHHGVNILEFSSKLTEIAQELVEQYLITQALDTKLYPNYGILYGKSTIMSASTIIKHFYETNAKYSFYFNKPNSEAAYSFAQIVWKSTTQLGIGVQHDSGYLFVVCVFYPKGNKKKEYGKNVYRWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD66</accession>
    <name>A0A0N5BD66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD66"/>
    <dbReference type="WBParaSite" id="SPAL_0000395600.1">
        <property type="protein sequence ID" value="SPAL_0000395600.1"/>
        <property type="gene ID" value="SPAL_0000395600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000395600.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23840" checksum="4384664EF2F87001" modified="2015-12-09" version="1">MNLSSVDETIKRPTTAISQPKVNLNTRLRPLDNKSTFNGTATSNNNLYNQRLSFSSTLPSNKLLTRYNTRKVTNVSMERQRIYPLSPLEKLNLPQMYGDNSTSTYPAHLNVESFSHSTRHTSGNVPKKSIVSSAKYSTSGIQRKLTTKNNSTTLKKTKIKDFLRKKSKITLKCFCILILLLIPIAIFVIMIVYSSSLELDKPRETPKKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDK4</accession>
    <name>A0A0N5BDK4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BDK4"/>
    <dbReference type="WBParaSite" id="SPAL_0000408700.1">
        <property type="protein sequence ID" value="SPAL_0000408700.1"/>
        <property type="gene ID" value="SPAL_0000408700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000408700.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19362" checksum="001C1FF561CD897A" modified="2015-12-09" version="1">XKWIPLASDELVEKEALLVHSFGHFNWRKVAAVLKHKVYNPKLESIVERCISACKTCQQCNVNGKKVKVSNWCSYMVPRENYAADICGPREGKYILHMVDSATLFWMVEVIPNVESDTVMMASLKLCWKYGFPNSWRSDNAPYWNKTMEKLGEFGCDVSTGNPYHHNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEW8</accession>
    <name>A0A0N5BEW8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BEW8"/>
    <dbReference type="WBParaSite" id="SPAL_0000453700.1">
        <property type="protein sequence ID" value="SPAL_0000453700.1"/>
        <property type="gene ID" value="SPAL_0000453700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000453700.1"/>
        </source>
    </evidence>
    <sequence length="1577" mass="180443" checksum="C3CFB319A194C5C9" modified="2015-12-09" version="1">MDHRFEHFFKTTKLDSTNDLPFPLESQHFYIHNGVEEYLVVENNVIKRIAAKHDCIKLCEYTVDFFDVKYARYYEFRNKDNRIVPVICAMGEQNIDIFGINDPFQHSIKFPFFVKKYFFIKACIIVVREDFVPAVEATVPRLFSIYEPKPRYIPLVLNYQKKKIINDIDHYICETMEFNIEDVDYESNTLLCSTNEGLLLLHTSEFHGTDGEVELQKYTTATTIDDSLFKVPDNPSLTSNLNNSLDVEMKSNDLRYSHLLTPKRPDSNMSTSYNSRMSPVTHMTTRSMSKAQKVSESTLPLPIINTIENTPQFGLPSKSTSYHNRFDNGDSSRNISGINLQSHKLFSKNILKPDKGCSFISKIKSDRSRNQSDASFIEINKSLRATALDYEIESESKSKMFNDGNKTTESVSEERSRKRSRLSRDSEDNNKTKESVRFSDIPTTGSMGNKLNNYSSGNHNCSYYVKLSRTNTNTVDGLNETLADVLSWEDEGFKITVIASFANNSHNTSPPKKVPKIFSSIDLGGRQYLYFMDKEDSKLAVYELIYGVKGDKEENQVSVKDIGFLINCHDAVPLLNSNFVALLQNNKKLSIHSGINFIFSIPLNTVFEDIIEDSKQLCQFLAPRRKGFVFRNNTNDTVYSVIMDFNLPRKLFECVATICEFSKDDGIIFFSTYLHSTNLLKDLVFHSCIQMLPCLYEFILYFLSECGFDVDFYIKSSRIKNDIKELNSYWFLSHENEPNTCFNKININDSGSFLNRTPRKHSFLSNISFNSTHDNNSFNQQKVLSSTPNRSSPSLFAEFLRKSTPSRSSAHNLLINYSIHSGVLSKEPTSSTPFRETENNLSTLTLTPILSHKVDKCKVDNDSTSRLQKIFTALHVFYERSRINRNNEILCKVIGEPLYAFALYCELHEYIQTYEQDFPLFMENKQVLQNSLISVGTSVFDKHAISKNLPLSCSFRRLRSKMLKLQCIEDEQSMFVAVPPQYLLIYGMLIKKINKVKHIQIIFGDNWEQVLAIPNKYLFLRLFSGISNYLVRAKAIFLELGLNPNHALELQLSPYPVFNKILLNYSSLYLQRITLKPLFEFLSESNFKDFLLHRFPEDIRYQNVLNMLDTSKPVLIQVRTISTMSDSDIREYQEDFLTIAMCKYYTKPFGKAIVKFRTVVPDIYNTFTVDNICVSGKVLPMWTTIDTVNNEANRPYTEWGDFYNGTARGLEILSADSLYLSSEFLTSVINNQNQKNMHAAAGLVYGLGLNGHINRLNQFVCHEMLTRGDKFFSIALLLGFGASNIGTADQGLFKIMASHLKFLMPPTQLELTIDSTIQASAAVGLGLLFCGRETQELTDKFIKQMCKENYVESDMIVQRYSFSLACGFAVGLINLGKGNHKNSLSLPISDAKPSIAHRLLNMLNGGAKESDNSRQIDKFDDCFNVSSVPVGARKRLEKSSQSTTNHVRELQNCNIHLTAHPAAVALGLVYLDSNIEWLDKALRIPDSFYELKNIKPDVIMTRTIARLLIGFRNVKPTKEWAEEQIPLSIRQRFKDITDPSKRGEEDEDIVYVHAYFYIYCGALFVQGLKFASTWDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF87</accession>
    <name>A0A0N5BF87_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Abhydrolase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF87"/>
    <dbReference type="STRING" id="174720.A0A0N5BF87"/>
    <dbReference type="WBParaSite" id="SPAL_0000465500.1">
        <property type="protein sequence ID" value="SPAL_0000465500.1"/>
        <property type="gene ID" value="SPAL_0000465500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000465500.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30212" checksum="74F33590217A40F4" modified="2015-12-09" version="1">MVLYDALSNDFLYSCSYFCPGYKPDEAIKSFVEVLKEQYEKNLIEVTKKELDVNYGPNNVDIWGDKSDKLFVFIHGGYWQEGCKEDGSSVVKPLIENNIQVASVGYTLANKIPLGETIEEIKCCVSFLHKKYPSSEIILSGHSAGAHLAAKVCEDEVIGSIVKKLVLYSGVFNLNDLVGTYIGNPINLTVNNAKEYSIDYEKLKKNYKGKSVLFVGGFESPKLKQQSNHFSIELKAPYHIIPNEDHFSYIKKLADVTSPATIMTISIINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFP6</accession>
    <name>A0A0N5BFP6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disintegrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFP6"/>
    <dbReference type="WBParaSite" id="SPAL_0000481200.1">
        <property type="protein sequence ID" value="SPAL_0000481200.1"/>
        <property type="gene ID" value="SPAL_0000481200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894524" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000481200.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17457" checksum="A34C09C4FE144980" modified="2015-12-09" version="1">MVSTKLLLITTLYFTSIKIAHCDDTIACTASTDCTSTQKCIDIDGVNKACVEVCTTDADCGGTAGSCAATTTGDVGGATGFSLCPLIVQQCLTDADCIAADPTLPSCNLYSLTCVADTTTMTTTTVAGVTTHKIIFHHFLQFLYDLYTQNLNVSPRVVLFVLNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGU5</accession>
    <name>A0A0N5BGU5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGU5"/>
    <dbReference type="STRING" id="174720.A0A0N5BGU5"/>
    <dbReference type="WBParaSite" id="SPAL_0000519500.1">
        <property type="protein sequence ID" value="SPAL_0000519500.1"/>
        <property type="gene ID" value="SPAL_0000519500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="248"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000519500.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54577" checksum="6606C58172AC21B3" modified="2015-12-09" version="1">MDEKMMEETATDDNNNISNCEDDEKKGDRKKLKDKSKVSLEQSTASINVLKDSVTCSKDFNNEEVLSVNSVMSVIQVERILDGIEYYKDRKLFEKITSKNKPTFAQTITYTTNDDVTLSGAIKDNINGGDDEVLSNLSTKTDLLSRMILNGPKKFLFNYGELLNLLSSATKIFENENSLLTSPLPCVVYGDIHGQYSDLFRWFQINGWPYNTRSVFLGDFVDRGTHGIEVIALLCAFKVKFPKNIYIVRGNHEEEALNKYYSFYDEVLLRFGKESGEEMYKAFRKLFSFLPLSVLIGKKILGMHGGLSPKLTSLKCIQDIKRPINNFKINTLACDLVWSDPNNASKNSGYLPNFNRDPINSIGQLFGKKAIDETFKLLNIDMVIRGHQVPLKGSSLYSDGKIMTLFSAPGYRGKSEETINCGGSCYINEDFVITLKKIKVTKQYRDNRRAEVLLQMKRRKLSIKMANKCDSESEKSDSQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH72</accession>
    <name>A0A0N5BH72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger BED domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000531600.1">
        <property type="protein sequence ID" value="SPAL_0000531600.1"/>
        <property type="gene ID" value="SPAL_0000531600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000531600.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29620" checksum="8328A046C58FE44A" modified="2015-12-09" version="1">XENDFNDIINDIEESLNFNDSEFESMEVDDVLSISNVDNNVDTINLSTQFESPIRIWCLSHKLNLLFKDLVNMECFKLVQHIYTYCVSIRRRDKVHSYLKQHTGKGIILVPKTRWIYAYRMVHRFNQLSSQLKGFEDFYFDDEDIKAAKEIESLLNVLYITSENMQKNSFGMKDAVFILGKLDFLVKKLEIRDQFKNAYFEAAKKRFSDVLDISKNSIFYISAFFNPNVDKRLCLTSKTQFSTFLHFLIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHW2</accession>
    <name>A0A0N5BHW2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exo84_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHW2"/>
    <dbReference type="STRING" id="174720.A0A0N5BHW2"/>
    <dbReference type="WBParaSite" id="SPAL_0000554700.1">
        <property type="protein sequence ID" value="SPAL_0000554700.1"/>
        <property type="gene ID" value="SPAL_0000554700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="7">
        <location>
            <begin position="309"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000554700.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="80736" checksum="9E54DEFDB0B2275F" modified="2015-12-09" version="1">MDDDDIFTSENFNAANYISNQLRDINISQGTKKLQQFRQQLQAIDNESAEAIRKIVFSNYKEFIATSKEIAILERETYNLTSLLNEQKKLIENLIEHNDQDKMSTRSVSMNTLSGNQNNLVQVILQKMDGVARILNTQNDSIKILLHGEGILIDPDTHNQIHSIMLVLLTDKLLVGFPSTGGKYKYQFHASYQLSGLAAVNVKNRGEPENADASQKDRMFKLLVFPDQYYIMCNTVRLKKEWLEKIDSAKKEKLHESNLIRQNTIRGRRTSTAEFAAKLENKINERAGRLSLVPEDDSNNFIDNDDQVWLSELPNELEVIIGQRNFEQAVEMILEWKNTKCRDAEINSQLQACERKLVQILSDDIRYGALHGGPKAVRKNINLLTSLGRKTQAVDLYLKRRSGILRGNARDLQVSEEPLSYVKKLCSLFITDIMSVANESFNQPQYSLVIQWCSGELSLLLSLIRRHVIEVAPTMAVCAHTWRILINQCDKLVNIGLDLSFEINRLLIPSLKEAVTSNFGNILESIRLRVSEERWKMYSLESDTNLNRFLEEMTDLEMSIDWSVSPTHPACINITQNACHFAKSAYTVSRDFGLLDSPHIHKLGVNCIITLWKVFLNLLSSPDIPNNETSKIVHKTTCQFIVSQVLPLCENIFSYQLPSGEGILFQLVRINYPSLAGFLPEPETPRSGETSSIDDEGDFDDNNSDDVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BII1</accession>
    <name>A0A0N5BII1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BII1"/>
    <dbReference type="WBParaSite" id="SPAL_0000576500.1">
        <property type="protein sequence ID" value="SPAL_0000576500.1"/>
        <property type="gene ID" value="SPAL_0000576500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000576500.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38289" checksum="38EBCB44047316BF" modified="2015-12-09" version="1">MHRFTASDTIEHVDPLLVTKYNLILVKTGKLRDKYLEETINKKNEKLAKAIEILKNKASDDVRIFELSENGLANSLYSFLYDVYVSLIPPDDRIKNGSITIMFQTFYEVFSIDINETSSYKLDVKKFQKICSSRQKRLQLNFDNLNSPEKNLLKAVVSEIKNVDSVLTFSEYAFDNSRINYLKENIKNIFNFKVQQNNLQNQNTIGIDIVENGLKRIFQFFFKMNPTYNPEISKIDPLYIALNFISQHFKLKEFIIPKKEISVNFNGIAYSGSITRDFRVMLGTYIVEKGCDLKEIIIYWRPVSSPLAILHFSTLVKCVLTMSILYCNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIS6</accession>
    <name>A0A0N5BIS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIS6"/>
    <dbReference type="WBParaSite" id="SPAL_0000585600.1">
        <property type="protein sequence ID" value="SPAL_0000585600.1"/>
        <property type="gene ID" value="SPAL_0000585600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004296">
        <property type="entry name" value="DUF236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03057">
        <property type="entry name" value="DUF236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894318" evidence="2">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000585600.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19526" checksum="55F08A87C0B93600" modified="2015-12-09" version="1">MFYELLTSFCTVASIVLSIAKCSKENQTGTNGKTAATISKLKDDTPSVKKTNENKKTSDEKAIAEKESNNNQKVNASSTDNFKRPEDQNKFAKRKDPNYMTLNLVLDDCFEKTGEKLSPPKDTKKSENSSKEAPKKTPAAEIPLPQKPKNCGIAGSADPQYQTLNFFSDECFNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIX8</accession>
    <name>A0A0N5BIX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIX8"/>
    <dbReference type="STRING" id="174720.A0A0N5BIX8"/>
    <dbReference type="WBParaSite" id="SPAL_0000590700.1">
        <property type="protein sequence ID" value="SPAL_0000590700.1"/>
        <property type="gene ID" value="SPAL_0000590700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000590700.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20497" checksum="9C671B00712AD77A" modified="2015-12-09" version="1">MMMIQDQVYFDLYVEEEMINTWTQSDTKKALVGALVPAGVAAFTACSVFKDKEVREFFDSFCDCKCAPKDPSVYAALDIMTFSPMGYAAYMVFKHGGGFDYNDTKVAMGLYGATLASWLAFTPVAKKKDRKLVLAHSSVHALLAAATCYSFYKIDETAGKICIPVAILTGMYALMAYGGYRKHANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJZ9</accession>
    <name>A0A0N5BJZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4477 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000626500.1">
        <property type="protein sequence ID" value="SPAL_0000626500.1"/>
        <property type="gene ID" value="SPAL_0000626500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000626500.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18583" checksum="DA7C275F60C3070F" modified="2015-12-09" version="1">MIKNTNEISLHFRELSNSLELMERVIYKGNNSFRHKKFFDAFKQTYRQVNRCFMKSRLQESLTTALKQLPDEDCTDLHPRSKLKLESLLTKIDEVLESHTRIKMGPMKRMVKEASLILDARHHVAFCQVSLGVMGEINKGTTDIVNLLKSYQIVVRQAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK35</accession>
    <name>A0A0N5BK35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neurogenic locus Notch protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <source>
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    <sequence length="1748" mass="194199" checksum="0245CDBE436E64E1" modified="2015-12-09" version="1">MKNVILLILIFSWKKFVLSEKFCNANVCFNGGTCVIDEGNLTFSCKCQDSFFGTLCEKSNLCSLNCGENGTCKNDSNNEEYCECKTGFEGSLCDQEINPCTNNKCSENSTCMAEGNQYICNCNNGWYGEFCELDVDECEFEPCKNNGTCINLEGAYKCECLKGFTGDVCETEEKGECVCENPLHVCSKDDKGNIECKCERENCDTTIESCMTKECQNGGNCVINDTNNQTFCMCPSNFEGNFCEKYTGACLVEGNECKNNGTCRISPAGTFCECPQKYSGKYCEVLTFNSLNTPRPTPLSEICSADYCKNNGKCVEIRGAPPKCVCSYPWAGDFCEISISEPVSSCTPNYCLNDGICSIKDNEAECSCIPNFIGKNCQIECDCNVNTEACIEDPTKPKGYVCISVIDDPTNEKTTTFIPNNSNLTNNITTTDTLITTTSLSELMTINTTDISRTTILPLDVNVVKSCSECQNESKCKIADGRKICLCQKNFSGLYCEKKSDLCSNVECKEGQVCKIKRNIGGKEETFCSCSDGFHGGNCLHDSTVSFKNSSLFVYQSKDFVSGLSQNLPYSLSLEFRTTIPDGLLILGENILAQVQYYIFLKNGRLIFQLLETQYAILSDLQLNDGEWYRIEMNKNENNIILEIFDSNYYCLTKKTFSVPQWNLFTTRLGKKVFSGKKSPNHYVGCIRNLKIGNENINLMDSTKSLDIKAGCKKIDQCLDKPCQNGADCHDLWDHFTCQCHRPFLPPFCIKAFPEVTFGHDDKPTMIKYSVSSNDSDSVKQSTDISFILQTIDDNSNIMYIGENGDEDVGTFISIEMINGKLGVRSRLGGKQIFSKIGTNNINKNGSHVIEILRENNNIQAIIDNTPEFTLSVDRPFSHPLLVDSIVIGDDSEVRNEAYTNKGQLLKAALQDLRINDKIILLQDSLLDDTDVDVFGKKIFEQNLLQGKVSDDICEKKNPCINGKCQNTFNDYKCLCKDGWTGKNCSYENYCLTNKCTKGTKCLSTNPGFICHGPTTFFNTSQSLFKLNIPENLEVEKDDNLKIEIEFRTTKINGHIGTLSYSNKSLSISISNGIIVIIQNNTDHEFRESINYHISDGYSHIIKVEENENGLYGYVDQFFDTQIGGSFKISEFLLDNTSQVNFGFSSTLGSFSGCINYITIGSLPPISFVINNNSTKSLEKSHFFKPITVENVKHNQCKAFDICSTSSCKNGGKCIPDPLGLSYTCKCQDGFIGNYCEEKPKVCLSNDNYCQPNGNCYDNGLKKFCQCKEGYKGERCEIEINGCDTNPCLNGAECENLQHGKYLCKCIHNYIGKNCQVLKNSTCSSNPCEKGKCTDLSESSFECSCNDGIEGVLCDTEINYCIDNPCKNGGLCVNEAKNFKCQCKEGYGGNDCSEFVDKCKTENPCIHGKCKNIWNGFQCQCEKGWTGEKCDIDINECNDMPCWHNSLCHNNNGNYSCECSNFYLGDTCNIPGSCLSNSCGYGDCRQITKDKHECLCHEGFKGDNCSIQIDYCGNNPCLNGGTCQNIIGGYECHCLPGFGKKDCSEDINECESEPCKNNGKCTDRINGFDCDCKGTGYRGLTCQEDINECIDVKGSCVNGICENLNGGYRCDCKKGYIGQKCNHLDPCINNNTTIQLCINGACVNPHVVSYDNGTEIVTHDCQCHDGFEGLLCNKKSEKFGDLPLPYIISILIVLFLVVFILLSALCCFICKAKRTYHGHYSPSTQENIGSKLHMNSMTLKRGPPERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKM6</accession>
    <name>A0A0N5BKM6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKM6"/>
    <dbReference type="STRING" id="174720.A0A0N5BKM6"/>
    <dbReference type="WBParaSite" id="SPAL_0000648200.1">
        <property type="protein sequence ID" value="SPAL_0000648200.1"/>
        <property type="gene ID" value="SPAL_0000648200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:double-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
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        <property type="term" value="P:DNA integration"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000648200.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8309" checksum="8EAF38B9B1C80237" modified="2015-12-09" version="1">MTAVKYCKEKEEMRKKLSVLKPALVNKRGPILFHDNAKPHVSKTTVQKLKELEYETLPHSPYSANLSPTDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLB6</accession>
    <name>A0A0N5BLB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLB6"/>
    <dbReference type="STRING" id="174720.A0A0N5BLB6"/>
    <dbReference type="WBParaSite" id="SPAL_0000671500.1">
        <property type="protein sequence ID" value="SPAL_0000671500.1"/>
        <property type="gene ID" value="SPAL_0000671500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF185">
        <property type="entry name" value="DOPAMINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="116"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000671500.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="71028" checksum="E32170579967953C" modified="2015-12-09" version="1">MNVVQTLLYFVYISDLAFGKNDKFLVSSLLPTIIDQVSLNAFENTSNQLNESIYSKLSNNLIQSKNNFLNDTVLTTINTNIEDVDKNEKNNTFLNSCWKVALALLLSFFCIMTISGNCLVVLAVCTKKYLRNPTGFLIVSLAIADLIVGLVVMPLNSLFEVTNHVWLLGLPMCDLFHAFDILASTSSIWSLCVISLDRYMAGQDPIGYRDKVSKKKILITIGLVWMVSACLSFPAIIWWRKASPQLYLDEYKCIFTNNWLYIVFSSLVSFYIPLILILFAYGRVYLIATRHSRSLKLGIKKVKSKKVVAKNSVNGGSGDIITNVDEPGLRIHYGGGVKNSTKGTSIPCLTQHHINDNHDSSNNLPSCGKYSLQHNRIEHVYINKFSSKAINKSSDLNKFQEINISTSGEGTSATPFITSQNNYKQESPHKKGNHKKSTISFKEDTNKKLGRTLTNKSLLTLLSDKDESSTDFHEKAQRKISLRKRLGMKEKSRQMVKYVHEQRAARTLSIVVGVFILCWLPFFILSPILSLCQDCFSDKQLIFSIFTWAGHLNSMLNPLIYSRFSRDFRKAFKQILICQKEKPSRSVIKSPLTIMFAQLVTVSTLSDDKEIIMPINQRLNQELKTSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLF5</accession>
    <name>A0A0N5BLF5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLF5"/>
    <dbReference type="STRING" id="174720.A0A0N5BLF5"/>
    <dbReference type="WBParaSite" id="SPAL_0000675200.1">
        <property type="protein sequence ID" value="SPAL_0000675200.1"/>
        <property type="gene ID" value="SPAL_0000675200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="504"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000675200.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="73672" checksum="5A1A568F0C5E4655" modified="2015-12-09" version="1">MAFKDLRFSKNQLDSAGTFYELMLLILKNKWMTDSNKDATIESECKTELLSKLDLEVMKEIREDIQKSLEDSTTKEIITSFKKLYMREDPDALRIINLFKNLNEKTSDLEFLKRETKMLEGLFGNLNGKQVAELYALLKWDAPCGAEAAILSRIVSSEKVSTGDEMIHMIQSITAMTVTANITKTTTVGKVYNNVATKKSLRKKNDIKCFLCGKMGHIKNHCPEYTIQRKVKLITERELMDREESDDDLSSIGVIDQVGKVSNGKRRLLIDIEIDGRKMKAEADTGSLVSFVSKANFDNNCIQPTKRRFCWLGGNEIKIYGKANVMLNINDKLFYAIVYVADIDHGIIGLEELKSAGLINSLLQLVSIINEPEKDEKAINKFVERFPKLFSPGLECYTDQPVRLKWKRESECTYKHTPCRPLTSEILKPIVLDKIKQYESEGLWCEEKYPISTSPVICIIKKPESGVCTENIRFVSDFKCLNKNLEKNCFPLESVDVTLKKGISSKEVKFELLKYMTYVGIPTYFFSDQGRQFIAEDVQQLIKRWGCSWIFSGSEHQSSNGQAERFVGTIKNALEKMGPNKGTVEERFARVIISFNNVECGIRKETPLSMIRERMVHPLIKEDERTSNSKFKKDELVMFKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLG0</accession>
    <name>A0A0N5BLG0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLG0"/>
    <dbReference type="WBParaSite" id="SPAL_0000675750.1">
        <property type="protein sequence ID" value="SPAL_0000675750.1"/>
        <property type="gene ID" value="SPAL_0000675750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000675750.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19975" checksum="D5C76FBC2476EAF9" modified="2015-12-09" version="1">MFSIPPVKLMYGGELFVVIYLNCKKYGIVTARVLPSKIDELPILSVECSLLNLNELKRMIHEMLFNYQRSEGSNYEKVYLDRIMSENERPLCLYQKSKFGLEWRRAEKAASNRIFKTHDALPAFTMNEIDPLRRFTDLIPTVTTNNLLQTSDTELQMLNFMFPTHNLHIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLI1</accession>
    <name>A0A0N5BLI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein quiver</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLI1"/>
    <dbReference type="WBParaSite" id="SPAL_0000677700.1">
        <property type="protein sequence ID" value="SPAL_0000677700.1"/>
        <property type="gene ID" value="SPAL_0000677700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000677700.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18684" checksum="EDA4BA4C1F529A35" modified="2015-12-09" version="1">MLEGKTEKCYSCGSKRVYTLWPKKEDNSYQYINELPFSVSDNCEQVKEELPIVDCTNSVCAKIVLQNYDKYNEITEESGRKNLIIRDCWSRILNVSGSHFEQGPYIEKKVHLLENLETKDTVGYIYTCTGYLCNSSNIIKFASLFIFCRLLIAYFQIFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLY7</accession>
    <name>A0A0N5BLY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLY7"/>
    <dbReference type="STRING" id="174720.A0A0N5BLY7"/>
    <dbReference type="WBParaSite" id="SPAL_0000693300.1">
        <property type="protein sequence ID" value="SPAL_0000693300.1"/>
        <property type="gene ID" value="SPAL_0000693300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894712" evidence="9">
        <location>
            <begin position="25"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000693300.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67796" checksum="75F7C1B5E924193A" modified="2015-12-09" version="1">YFPAGNSWPSVLAGMLSDALGCVGFSWAACPAMTELEMIMLDWFGNMMGLPKEFLPFTPNGNGGGVIQGSASECNFVALLAARFEILNGGGVIQGSASECNFVALLAARFEILKKLKERFPFVEEGLLMSKLVAYCSKESHSSVEKACMIAMVKLRIMETDSLYRLRGDTLYAAIQEDRNLGLIPFFVSTTLGTTSVCSFDVLSEVGPVCSENDIWLHVDGAYAGSAMICPEFRYLMKGIEHAMSFNTNPNKWMLVNFDCSTMWCRDRFKLTQALVVDPLYLQHSWTDKAIDYRHWGIPLSRRFRALKLWFVIRMYGVEGLQKYIREHVRLAKKFESLLRNDDRFEIIGEVILGLVCFRLKGSDEINRSLLTQLNSSGKIHMVPASLSSRFVIRFCVCQEHATDKDIQIAYDIITQTAQEILYEPSEPPLVEEDENEYVYEETRTSLYDVSNSGMDRSESYRLINSSESIPSGREKSIDSDSRSHHIPRQPSINDEQFDRKKIKTLSEKRSFLVRMVSDPKCYNPKIVRHLNRSSHRKMSQDIHRDHVMRKTIEESKKIKPKMGNESSYMDKSFIDTQEANDMVIAMEQTGIQPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMH7</accession>
    <name>A0A0N5BMH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMH7"/>
    <dbReference type="WBParaSite" id="SPAL_0000711700.1">
        <property type="protein sequence ID" value="SPAL_0000711700.1"/>
        <property type="gene ID" value="SPAL_0000711700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000711700.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30887" checksum="E9251FE79655C97B" modified="2015-12-09" version="1">MSTKQHNPPENTLDDPPKKTLDDSPKGSKDKHPDLSDPSLIPSVGKGSKKRGATCPIEEFARQLEANNRSLESFMLLGALGRMPSKNISYCCLMSSKSFEIYNRLVRADKMDKWRDQITPSTHSQDGLEGFKESINVNWKELFMGVTKLKILLTDSCEVFKKLEKLIAKMKTLQAVICMNKQGCKCYGSPLRKTFIRELSVVPNHENNNIYFADVARARKTRKPNPRFHYFAKIYYRNEGILTKICSTELPSDIQEELKNSSSKNPKTMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMN0</accession>
    <name>A0A0N5BMN0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMN0"/>
    <dbReference type="STRING" id="174720.A0A0N5BMN0"/>
    <dbReference type="WBParaSite" id="SPAL_0000716900.1">
        <property type="protein sequence ID" value="SPAL_0000716900.1"/>
        <property type="gene ID" value="SPAL_0000716900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000716900.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30526" checksum="C8FE7A07CA8EBBB1" modified="2015-12-09" version="1">MPLKICIIGGTGLENMDIMKNKTLLKFNTPYGEPSCPFVQGEVDGVTVVVLSRHGDKHQYAPSDINYRANIWGIKELKCDIIVASCASGSLREYISPGHMVVVDDFIDRTTKRQQTFYDGKENHSAGVCHIPMHPPFNEKLRGLLIDCCKELNLQHHDKGTIVCIEGPRFSSRAESNMYRMMGGDIINMTVVPEVVLAKELGIPYAVLGLVTDYDCWKDADKHVSVELVAEQMKVNSINSLKVFLKLLEKLKDVNFTEECEKLHIIARNSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN20</accession>
    <name>A0A0N5BN20_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metalloendopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN20"/>
    <dbReference type="WBParaSite" id="SPAL_0000730000.1">
        <property type="protein sequence ID" value="SPAL_0000730000.1"/>
        <property type="gene ID" value="SPAL_0000730000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF819">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733523" description="Metalloendopeptidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="44"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000730000.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44941" checksum="08F4CB93E3AB6991" modified="2015-12-09" version="1">MISFIKLFLFSLFIYEVISNNEGTIKTDSNSESYETRIKKSIINNMKFKWTSPIPYFCRFNVNKKLVQEALAILEKETCLRFNETLDFTNGVLRYFNGTNGCSSSLGKLSNNDVHSVVVGRDCSDVIGVLHETLHALGVIHEMSRHDRDSYIDVKYENINSRHKFNFNRYELTETLPYYLKYDFGSVMHYNRYLGTKNNQETMVPKAKYWSYLRTMGQRTRLGFNDAKQLNIYYCSDRCRDSKLKCKMGGYPNPSKHKCKVCKCPAFFTGKECTDLLPSNGYCGKTRFLKADKKKDKYLKVSGTNKCYYKITASNGRKVRLIVSTDLPDSKVCHPNQGLEIKFLADKSVSGAVLCGKISGETITSESSVVYVKYEGLTSNSTIKIKYRDVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN23</accession>
    <name>A0A0N5BN23_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN23"/>
    <dbReference type="WBParaSite" id="SPAL_0000730300.1">
        <property type="protein sequence ID" value="SPAL_0000730300.1"/>
        <property type="gene ID" value="SPAL_0000730300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000730300.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42942" checksum="9C6DCD6BD587873B" modified="2015-12-09" version="1">MVVVFSKDEGILKADGNSESYETRVKKSILKNMKLRWTFPIDYRIHNDVDRRTVKAALAVIEKETCIRFRETVNFKNGGLNYVNGSKGCYAFMGKVSKIRPQDVNLGSGCNKLMIAIHETCHALGMIHEMSRHDRDSYIKLKFENIIDNAKFNFQHFDLSKATPYGLKYDFGSVMQYDRIGVSKNGRITMEPKYQNYLTTIGQITRFGFNDAKQLNIHYCSDKCRDSKLKCKMGGYPNPNDCRFCKCPAFYTGKLCTKLLPSDKKCGKTRFKSKYTNKLLIVKGIKTCYIKITAPRGRKVRLNILETNFHYSFVCQPNKGLEVKFFADKTVSGAMFCGRNFLKVITSENNVVVMKYVGLTRFSRVRIQYRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNB3</accession>
    <name>A0A0N5BNB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Degenerin mec-10</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNB3"/>
    <dbReference type="STRING" id="174720.A0A0N5BNB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000739200.1">
        <property type="protein sequence ID" value="SPAL_0000739200.1"/>
        <property type="gene ID" value="SPAL_0000739200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF267">
        <property type="entry name" value="DEGENERIN MEC-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000739200.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="79293" checksum="5BE292D0DC97DEE5" modified="2015-12-09" version="1">MTKRPSDYSFNSSNDTLLVDELNIPAVVDIFSKYEDPEANDNINKEVQCDLLNEHNILHHIDPTRLSYHERLTWHLNEFCNKTSSHGIPMLSMAPNYYYKITWIVLLVCCLCMFVYHAIDVVAKYQKNAKITDIQLQFDTAPFPAITICNLNPYKDSVIRNVDKIKKILDIYNDVMIKAGEKNRLDEEIRLETKSSPLIKRKKRDEDIEFEVAYSDCTCETSAEVDGKEECTENSKNIPNLVTDYCLCAFDRASGDAWPCHRKSLWSNNECASCDKQKICRLTNADGSPSLKIPCICYISDENFCVEHNPSDEILKLWEYYGMKTVDEKKIIEALGFRDMSDEVAIVTKAKENIIFAMSELSEAVRRSLSIQKHHLIQKCSFNGAACDIDNDFKIVTDPTFGNCFTFNHNMSEVKSSIRAGPTYGLRMLVYVNASDYLPTTEAVGVRVTIHDKDEYPFPDTFGYNAPTGYISSFGMKLQKMNRLPAPFGNCIPRGFNMTYIYKDYRYSTEGCYRSCFQNMVQQDCGCGDPRFPILNGSHCQAFDPVARKCLEEKTNQLGDINGTIKCSECHQPCEQSVYTVSYSAAIWPSESLNITLGSCADALEKCNEHYKENGAMIEMFYEALNFEVFTESEAYGIVKMMADFGGQLGLWSGVSFLTCCEFVMLFFEIIYMVITHHFNKRKQKKLEKDKFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNK0</accession>
    <name>A0A0N5BNK0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNK0"/>
    <dbReference type="WBParaSite" id="SPAL_0000747800.1">
        <property type="protein sequence ID" value="SPAL_0000747800.1"/>
        <property type="gene ID" value="SPAL_0000747800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894606" evidence="2">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000747800.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17649" checksum="F879F971D31D98A5" modified="2015-12-09" version="1">MLSIRTPIIFLLFIVFSSIVSVKVTTELPTSLTTTTTESSTSLTTTTTESSTSLTTSTNESTENTLDNISTDTTKYEKTTQLEENNSSTTADSKTSTDTTNYETTTQLEIDNFSTTANSKKCYDKGFKNGITCISVIEYCLNSEYKGIMEDKCRKTCNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNS3</accession>
    <name>A0A0N5BNS3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNS3"/>
    <dbReference type="STRING" id="174720.A0A0N5BNS3"/>
    <dbReference type="WBParaSite" id="SPAL_0000755100.1">
        <property type="protein sequence ID" value="SPAL_0000755100.1"/>
        <property type="gene ID" value="SPAL_0000755100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000002">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="279"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="644"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="816"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000755100.1"/>
        </source>
    </evidence>
    <sequence length="1052" mass="120651" checksum="2497A3A0AE816ABA" modified="2015-12-09" version="1">MINLELNSISFLGYQINYEAAKETLSELSTSFSIPWSSDKSRRSDSTSSILNFPLTEENSFLTELSKVQKNSKSKSTHLYNIQNNNNFSHVQNLNVSESLSIPIDYQIRRHSIGSAARKSHKHKIKKLLSNQGSISPNTMPDIIRHSSTNSSILSSRPSDFSQDTDSETNPLSDAEILESVPIEPEVSSLLLKMEELNKIIETDARSVISHKSVSLSSELNTETNSPTRSSSGSCRQNSCHLDDEDNIDLWTVWGNLVKNWEYEMKKRPNDVKDLVRRGIPQHFRTITWQLLSKANSNNIHDIYTDYLRQHSPYEKVIMRDIPRTYPELKFFKEGGRGQPSLFNVIKAYSIHDKEVGYCQGSAFIVGQLLLQMPEEEAFAVFVRLMEDYRLRELYKPTMTDLGLCMFQLECMVQEQMPDLYTHFNNMGFDTSMYASSWFLTLFTTSLPLDLANRIMDFFLVDGMDAIFRIAMAILQQARFDLLRLDMEGMLKYFQRDIKERYENDHDLLFTVACQITLNAKKMKKLEKEYMTKRSKEQEEAIELRRLRTENRLLRQRIDYLEQESSALADRLIRGQVDLAQKAENCLNISHELNILRDINSNAHKKLEEAFETIRELSSRPKNDNITYVDTAIQVDDTTMIEHIHQLQQELIETHTKKNDLENAIRECKLRLQEVELANKRLREQPPDDGIAGLQEELISVKMREAEASLSLKEMRQRFSELEQQWAKYVHARTFGAQALAMQSFDTLPKNDDDSGVTNSPDTGSPSSHTQSSTMSSSLSQQPTSARGRLANLTAKLMGAGFGYSNDEPNDSGMSMKEMEDQLMGLRIREADAVAELKEMRQKVMELETQNHVCTNQLKRQDEELKKLIAECESRKKTEKESAEQLKEEQRKGIELQSELKEKAVLQRLKYNEALNSIAELKQQIAHYESMNAEKVACAQLRGTSVCDMDDDSNTSHKSFNLNCDGGSLASEEMSVLIADVTIKIPEFIPDERKYLDSDEDIIEAEEKTRRPFRKNDNCKIEGNIGITETNKFRVREDENDTTDSGLNLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP46</accession>
    <name>A0A0N5BP46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP46"/>
    <dbReference type="WBParaSite" id="SPAL_0000767200.1">
        <property type="protein sequence ID" value="SPAL_0000767200.1"/>
        <property type="gene ID" value="SPAL_0000767200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000767200.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8242" checksum="74268242E8E33A52" modified="2015-12-09" version="1">MRNSETKLVANKENLNFIWWDKFITFFANLCPFFFCVQSSLQFSYFMPDFVKCTNISFIFFKQLCIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQC6</accession>
    <name>A0A0N5BQC6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQC6"/>
    <dbReference type="WBParaSite" id="SPAL_0000809100.1">
        <property type="protein sequence ID" value="SPAL_0000809100.1"/>
        <property type="gene ID" value="SPAL_0000809100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000809100.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10368" checksum="95CCD4E49E4066D5" modified="2015-12-09" version="1">MIQNFGKKSVEKYNKENDKNNRFVGVKKARKEFNGQHIHYELLVSTKKGDCTIKNEGDCSENLESDVFESPKKPNNVILEVQKEGQCAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQY3</accession>
    <name>A0A0N5BQY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Angiotensin-converting enzyme</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQY3"/>
    <dbReference type="STRING" id="174720.A0A0N5BQY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000829100.1">
        <property type="protein sequence ID" value="SPAL_0000829100.1"/>
        <property type="gene ID" value="SPAL_0000829100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894732" evidence="10">
        <location>
            <begin position="25"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6 8">
        <location>
            <begin position="310"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000829100.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="84908" checksum="CE526350BA5DD4D5" modified="2015-12-09" version="1">MRQIIKYCFLLLLTFLVLLNTSFGVTTSSSEFKDVTDVPVAITTDVDTTDLKNIEKINIFEEDSSTTRATPENRTTSETSLEKENKFATTKDLFEEKEVELSSESSTEIITKPKQDTIRINFDNLDKEDYFDAVETMKPAEVDDKAIDELVQKFLNTGTIGGDKKEKATFINKNAMKLVNSSDYWRLDNIKDEFSIDNEEEAEKWIEGYNKEAKKVLKEVSLAGWNYFAGVTPTTKQSLSEAEEVLGHFLSSTSKQAKQFNVKNIKDQILAKQLRLISVDGVKVLGENKSTEHDTILAEINKIFLTTDICDGKDVQSCIYKVTDISSIIQQEDNVNRLLKIWESFRDKIANSTKKNYIKLVGILNESAKAAGFTNTAAMWNSPFDLSTRDTPPEINIMNEVQNVQNKLMPLYKELHTYIRHYLPVLYPNATDITSDGPIPGHLLKSYNGDDWSAFYDTAKPFDELEDIESEIMKALHGQNMTVKGMFTKAYRYFKYLGFEKAPSSIWSKSIFTRVWSRSMICNPSTAIDMNDDNDYRIKTCIASGNIDYLKSLNLLPENYSISENSKINSLFKEAIEDFVKLPMYLVADLFRQEVFEGTLSPEEWNEEWWRLRSNLQGIKSPLKDEKKDNDVLVNTYVTQKHSPAVRYIISYVIQFQILRALCPDTPSNMLFNGCVLDKNIMNKIEIIMKEGATIDYLTALEMITGDRQFDATPMIEYFSPLYEWLKKYNEENGLYIGWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRD2</accession>
    <name>A0A0N5BRD2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRD2"/>
    <dbReference type="WBParaSite" id="SPAL_0000843300.1">
        <property type="protein sequence ID" value="SPAL_0000843300.1"/>
        <property type="gene ID" value="SPAL_0000843300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000843300.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41920" checksum="AD69327F30AEDACA" modified="2015-12-09" version="1">MSLNNPDIVSTVTVEMVIKPNLSPMEVGDLYLSGLTIAKAVALDPTTLAKDFFKKLMEEYGSEHAGNNFQVFIQNSNLEYYPLDSFFSDMNVGIASICPLLGNVLKAKIFAPLIFFDCIKMMKAIEVYGNLTNYLLSKMDRENGQIPDPVIQVGVANEIKSRPIRQHTMEALSQMHDKITHTIQSNIEGMSEVMSVFPTLVKSRPIRQHTMEALSQMHDKITHTIQSNIEGMSEGVFRMSDKNQSLDLSDVSFSYPGPLKLDELGDRSDVSTACSYNTLPSSPSSMTNEEDQPGTEPQKCKRIVFMKLEVPILEGWYKYHKSQGGISPNSDYLTEYAATLNCATKRSESNKVKPKNVYNWFKRRAAQEKRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BST2</accession>
    <name>A0A0N5BST2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BST2"/>
    <dbReference type="STRING" id="174720.A0A0N5BST2"/>
    <dbReference type="WBParaSite" id="SPAL_0000892400.1">
        <property type="protein sequence ID" value="SPAL_0000892400.1"/>
        <property type="gene ID" value="SPAL_0000892400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="166"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000892400.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37771" checksum="0964E33DABA30F90" modified="2015-12-09" version="1">MDSTVTFESTWEVSKAEIFKDLFLSLQSPIFHNNQNEETKWRLNVHRRIDADKGDEFFSFFLNLENSLPEKTKAKFKLSLLNKRQEKVLPKESPVENIHGRELCYSFFDFFGKKYINNNSSDLLFDGNLKISCEITLFGDSKDKNNSQNPTPVLDTSKLLFSHQYSDFTITVDGVDLKAHKMVLSLRSPVFDAMFNSNIQESQSNRVEIKDFGINVVREMLTYIYTNTCPKIKELALELMMIADKYGINDLKKIADEQLYQSLCEGNACDYLIVAHTYSNSRLKDFCLDFIVLNAQNIVKKKNWREFVVKYPPLLESLLKRALKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT30</accession>
    <name>A0A0N5BT30_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3 11">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT30"/>
    <dbReference type="STRING" id="174720.A0A0N5BT30"/>
    <dbReference type="WBParaSite" id="SPAL_0000902300.1">
        <property type="protein sequence ID" value="SPAL_0000902300.1"/>
        <property type="gene ID" value="SPAL_0000902300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047975">
        <property type="term" value="F:guanosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="13">
        <location>
            <begin position="51"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000902300.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33371" checksum="3F8EC2019EEBF2FC" modified="2015-12-09" version="1">MSLESDATQGSNEILNHSVLSREFDPRNYDHVYELAQYILKIAKLPKVPSIGIICGSGLGDIAEILTEKIVIPYSDIPGFPTTNIPGHKGNLVFGNMGNKYVVCVQGRFHAYEHDMNMALCTTPVRILALLGCKGIIVSNAAGGIPDKVTYGDLMLVKDHIFIPGLTGLSPLVGLHDSRFGPTFVSVHDAYDREFRAVAKNVAKRINLHLPEGILVMSGGPQYETPSEVRLYQTLGANALGMSTAHEVTVARQCGLRCLAFSLITNVCNLEVDGAVEVCHEEVLEMSKKAGKTACKFVYEIVNDLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT46</accession>
    <name>A0A0N5BT46_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT46"/>
    <dbReference type="STRING" id="174720.A0A0N5BT46"/>
    <dbReference type="WBParaSite" id="SPAL_0000903700.1">
        <property type="protein sequence ID" value="SPAL_0000903700.1"/>
        <property type="gene ID" value="SPAL_0000903700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="26"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000903700.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="45247" checksum="13F1EC59568D3C69" modified="2015-12-09" version="1">MFDIKVQRNSSEFKADTITSDEGNHIGLPNKGNTCYLNAVIQILYRCKLFRYEILIITDIMTKYIENKKLKPNIQRAAETIQALNVLFQSLKVKSLNGLSYFMTKFSKLKPKFSIYRQQDAHEFLSYILEALDDCKEFLKQSKEPLIFESTFNGSVTKNIICQNCNKCVESREKFNILTIPVDTNHDTKSSKYGAWSLARWSNLEMLDGDNKYQCDNCHSKQNAFMFPWIEIKPCILILHICRFNVSNDNSLSSVFNFNTAEKVKGTFPVPMFLPLMHHYFHGKYRNENYYKNILEIYESPQKIKEQYNTKEYINKSYVGYYLYGMIIHIGRSLSSGHYVTATPSQGNYLKWNIYDDQNVKKIDIFEIFENKMYSPYLIFYEKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTP3</accession>
    <name>A0A0N5BTP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPXV160 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTP3"/>
    <dbReference type="WBParaSite" id="SPAL_0000922000.1">
        <property type="protein sequence ID" value="SPAL_0000922000.1"/>
        <property type="gene ID" value="SPAL_0000922000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000922000.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8338" checksum="C4C760B7FB79D815" modified="2015-12-09" version="1">MIINFYVPIIYIILACICVRYRFKFLTNELVYKFLADYTPILAQRLLTCINSKVVEMFLYSITRNALSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTR4</accession>
    <name>A0A0N5BTR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTR4"/>
    <dbReference type="WBParaSite" id="SPAL_0000924100.1">
        <property type="protein sequence ID" value="SPAL_0000924100.1"/>
        <property type="gene ID" value="SPAL_0000924100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000924100.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39127" checksum="0E6620F96FD6F063" modified="2015-12-09" version="1">MSDTWRSVVEEPDTDPETVSDNLFTRSINVIRNNLFGHHFEDSDDVSSDDQSLGENDVASSVDSLLISGLLDLSVSVAEGARSNEDTDLDDMVEGKAWVLYPAYEEKNGSMKNYVRKLELIMECDGVKSASTKMNILKSKLSDETLDELYQLVDGEQVSTYDALKEWLYNRFSDDLSVSNAMIKLRGFHTRVDESHLSKDLTEVAELVMKSSTSKNQSDIVNRTKERFMDKIGDDELFKRLLSKDYSSVSEMINDLCTVFMLSNKRRNDSQKKLKDRRITPNDSGNRPVKFNGTCHSCGIRGHKAVDCRKKRLDNDKSSDKSQQSKINSNIEIIKHNTLPLIKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTV8</accession>
    <name>A0A0N5BTV8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="WBParaSite" id="SPAL_0000928200.1">
        <property type="protein sequence ID" value="SPAL_0000928200.1"/>
        <property type="gene ID" value="SPAL_0000928200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000928200.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56547" checksum="DC9B3D8E4F7EFEF6" modified="2015-12-09" version="1">XNFFSQIADILTEEGHDVTVLTIDLDPTIKHPGAYKAKVITYPLTKEIEDHFVNMTDSKFLWNLSSSGLDQYKMLMRFIDGQYKQLLRVFNDDELTEKMKKEKFDLGIVEAFHFSILGMFKVWGLKAYVTGFSMSLSDGFYKDFGLQFPASYIPNHMSPFSEKMTYEERFQNLFNHHFGSKLLSLLSDKMTLQKEFDEKYGLAFFDSENAVGDSSFFVINSNPFLDIPGPKAPKMVEVSGIGIKDPKPLGEYWNGILSMRSRTILVSFGSFAKAIHMPEKMKQGLLETIRKMKDITFIWKYEEPEDGTGKNIENLVLSKWVPQNDLLNNEKLSLFVTHGGMGSITELSFRGVPAVVIPVMGDQLRNSKLVERQNYGIIMNKLDLENPDILVKNIKTILDDDTYRKNAKMISRRLNKRPIGSKRLLIEHIEFAAEFGKLDMLDLASRNMGVIEYYNLDIVLSVFFGLFLFVCFLFYVTFKIIKKLFTSKVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUC4</accession>
    <name>A0A0N5BUC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Delta-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BUC4"/>
    <dbReference type="WBParaSite" id="SPAL_0000944500.1">
        <property type="protein sequence ID" value="SPAL_0000944500.1"/>
        <property type="gene ID" value="SPAL_0000944500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000699">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
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    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="155"/>
            <end position="193"/>
        </location>
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        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="620"/>
            <end position="702"/>
        </location>
    </feature>
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        <location>
            <begin position="703"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1348"/>
            <end position="1366"/>
        </location>
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        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
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            <begin position="46"/>
            <end position="56"/>
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    </feature>
    <feature type="disulfide bond" evidence="6">
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="301"/>
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        </location>
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    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="378"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000944500.1"/>
        </source>
    </evidence>
    <sequence length="1366" mass="153675" checksum="6DCEC8DD54FE9BEE" modified="2015-12-09" version="1">MVINGNDCATNPCAFNATCTDLINDFQCSCPEGFEGKRCEKKVDICQIHPCHHGSCVDSLFSRRCICDPGWGGESCDININECQDNPCKNNGLCIDLINDFECQCLPGYYGSICQYKINYCSGEVCQNDGICVSGNDSFICKCPNGYDGIRCENNIDECKESRCNPEGTLKCKDGINKYECICKKSFIGKYCDERIDECQRNPCYNGGVCYYNDNNEVKCKCGRGWKGDYCQEEINMCSVLSNPCQNNGECIPLPDESFYCSCPDGVTGPKCEILPNLCLGEQCLNGGTCINNGTSSHCVCLPSFTGDGCQYIIDRCDEDYCKNDGECIIEQNDAFKCKCRPGFTGERCETNIDNCYNNNCPEGARCVDQINSYECLCPYNKTGLACDKLVDVDYDLKFLDGMEMAQATLSVPVKYSGNALSISLWVKFDYGPKGGGSILTLYNSENPNYDKNSREILRITDKGCFVKLFKDDEEIILRFPQNQMINDGNWNHIAFIWNGYDNNGRYSLIWNSIRIVQDGGNGQNSFLDSNLWIKLGSNSDDDNKFVGSITRVNLWNRVINFDTEIPSIVKDCQGAEDIFDGLLIRFTGYNKIKGKVERSSKSTCGRRVLKNRENVISLNFEENIIVKNCPQDILVTTNSRYVNVTWNEPIFESSSGLEIKTIEKNLRPGQVFIPGDYMVLYVGHDENNNVGECHFHIYVSSNHCSSPEDPINGIQACEQWGPNNQYKACSITCHDGYEFPIEVPSFYSCSAEGLWRPNINQHNFKYPNCAKSHNANRVVRIYVNFPNNGLCNNAAKNALAEKVFQKLQYLNTKWKICNEKLIDSDDISCSHLNVTIECIKNINNRVRRDDNVPSQMFNVTIEMGVKRDSETSQNIKIIDLLHSEILLDDIFNFNQVIPNGIPDLNSLRIDNVYHCQFGTVLKDDVCVPCAPGMAYNIKKNICEYCPIGSYQSREGELSCILCPDKTTTIGYGSVTPDECKPSCEEGHYFNIQTSICEECGVGMYQPEKGKFNCYACGVGQTTLLSNSTSSDDCRDECPDGEQMTIIGICQPCPQGSYRTKGQHRQCQLCPEGTTTESHHSINKTQCNLPKCMPGQYLYLDERKCKLCPRGTFQDDVQQIKCKLCPNDHTTASQGATHESQCYSTNQCDTGENDCSWHALCKDLPDDGDVPSYECSCKPGYRGNGTLCIDACTNYCLNDGICKKNIQGFVECVCKENFSGERCEIRFQPKQQKLFIITVSIVAVVIIFIIIIVIFWMNNYRFNRVKNFNDKDKTSFKNDLALNSNFVYGTSNLQPTLNVGLEMKSTLGGNGVLTRPIGYYYEDDEEYSETSVVKNENKHIEMRHERFSQVSQELKSTDQGTLQQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV20</accession>
    <name>A0A0N5BV20_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV20"/>
    <dbReference type="WBParaSite" id="SPAL_0000968800.1">
        <property type="protein sequence ID" value="SPAL_0000968800.1"/>
        <property type="gene ID" value="SPAL_0000968800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
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        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895043" evidence="5">
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            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000968800.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16509" checksum="2A337993FC2126F7" modified="2015-12-09" version="1">MQFIFLIFFPLFIFDISINGLGLGRKQTAGAKGKLVCDGKPATGILVKLYDDDRGIDADDLMAKGKTDGSGFFELSGYTHEMTTIDPKVNIYHDCNDGFMPCQRKFTIYIPDDYVFSGEHPTKYYDMGTLELSGKLKGEERDCIHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVT0</accession>
    <name>A0A0N5BVT0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="6">1.3.8.1</ecNumber>
            <ecNumber evidence="5">1.3.8.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="6"/>
    <dbReference type="EC" id="1.3.8.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVT0"/>
    <dbReference type="STRING" id="174720.A0A0N5BVT0"/>
    <dbReference type="WBParaSite" id="SPAL_0000993600.1">
        <property type="protein sequence ID" value="SPAL_0000993600.1"/>
        <property type="gene ID" value="SPAL_0000993600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 22" id="KW-0274">FAD</keyword>
    <keyword evidence="8 22" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="25">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="24">
        <location>
            <begin position="154"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="23">
        <location>
            <begin position="261"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="368"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="395"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="397"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000993600.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45428" checksum="34946711E6A6AD99" modified="2015-12-09" version="1">MLLVKNIFKKTNQISNLSRVGRFSTYPIEDDMFGLTEEQKHLRKTVFDITQKELAPYASKIDKDNGWDNLRNFWKILGENGLLGITAPEKYGGSGLSYFDHCIAMEELSRGSGAIALSYGAHSNLCVNQIVRHGNDAQKEKYLPKLISGEHMGALAMSEPNSGSDVVSMKTTAEKKGNKYILNGTKFWITNGPDADVYVIYAKTDIAANSRGITAFIVERDSPGFSRSPKLDKLGMRGSNTCELVFDNVEVPEENVLGGVNKGVYVLMSGLDVERLVLAAGPLGLMQAACDVSFDYAHQRKAFGKRIGEFQLLQGKMADMYTTLNASRAYLYAVARGASQGNIVSKDCAGVILYLAEKATSVCLDAIQILGGNGYINDYPTGRLLRDAKLYEIGAGTSEVRRFLIGRSINNEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVU8</accession>
    <name>A0A0N5BVU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVU8"/>
    <dbReference type="WBParaSite" id="SPAL_0000995400.1">
        <property type="protein sequence ID" value="SPAL_0000995400.1"/>
        <property type="gene ID" value="SPAL_0000995400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000995400.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8931" checksum="29EB5A1BD8C50B8B" modified="2015-12-09" version="1">MDEKIELSDIEIQQIKEQNQERIKKVVAYVAISLTVISIILVALSLSFGPKIDSLVNDQLDQRLITKQLILGPNPNISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVX2</accession>
    <name>A0A0N5BVX2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVX2"/>
    <dbReference type="STRING" id="174720.A0A0N5BVX2"/>
    <dbReference type="WBParaSite" id="SPAL_0000997800.1">
        <property type="protein sequence ID" value="SPAL_0000997800.1"/>
        <property type="gene ID" value="SPAL_0000997800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF250">
        <property type="entry name" value="CARBONIC ANHYDRASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025095624" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000997800.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36071" checksum="C53FD7B4FBF551A8" modified="2015-12-09" version="1">MYNIITLLLLFTPTILSDGASYSWGYTGDNGPDKWKDTCSDGIHQSPIDISGENVIVKHMPRLHFVKYNHKGNITLINTGSSIMASGFTDWKNNRPYIAGGGLNSKYHLVQWHIHWAQENGNGSEHTMGMLHYPAEIHFVHVKDGLTVSQALEQSDGLAVVGAFFVVKNGGSNSFFSENNGINMESFFDSIADKDMNTTVSHHRPRTLLPKSVDSFYRYEGSLTTPGCNEAVVWTVLDNPIVINQEEMNALRRIKTVTHNNRPTQPLNGRKIFYRPHNIQSFLTDYIAQMPRSSTSKTIPSNYITVIPLIFAMIFKNFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWL2</accession>
    <name>A0A0N5BWL2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWL2"/>
    <dbReference type="STRING" id="174720.A0A0N5BWL2"/>
    <dbReference type="WBParaSite" id="SPAL_0001020700.1">
        <property type="protein sequence ID" value="SPAL_0001020700.1"/>
        <property type="gene ID" value="SPAL_0001020700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001020700.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38533" checksum="9596502C15D36677" modified="2015-12-09" version="1">MPTIPSLKKNRILNCDYCQFRVLKLLGQGGFGAVYLVEELISKGKYAVKTELIPREKDKFQPRLLWEETILLEIQALPDENQKKHFIKIVDRGALPPLRYMLMTLVGKSLFDLQVEQKKKRFSDNTCWRIAEQTLEALEAFHNAGFVHRDIKPQNYTIGAESREDIIFLLDFGLVRCYTGKKFTHNIIDRPTFAGTLKYCSRSAHFNVYQYPKDDFECWIMCMMNFHHQSSIYWSKESNLAQIKNMKMKLFAGKEPLKIFKKLVPSDYRGLIEMIGNLTPLDLIKKPNAEMRAKVYITPFYEKLKEIQKNYRFSNEKLFDWQKKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXF3</accession>
    <name>A0A0N5BXF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXF3"/>
    <dbReference type="WBParaSite" id="SPAL_0001048300.1">
        <property type="protein sequence ID" value="SPAL_0001048300.1"/>
        <property type="gene ID" value="SPAL_0001048300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895083" evidence="2">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001048300.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14569" checksum="B123002369A3AF1A" modified="2015-12-09" version="1">MLLLNNVVFILLFIMSPYVYCGKKQEPETHNVRSTRKKSSRRHGRGRSDKADRKRKVKDENDDKPPKKETSKNASHHSNVKEPEIKPLNEKEVKIMNNQVKADENEYPTMMDAADGFKNTPTIDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD4</accession>
    <name>A0A0N5BZD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BZD4"/>
    <dbReference type="WBParaSite" id="SPAL_0001112500.1">
        <property type="protein sequence ID" value="SPAL_0001112500.1"/>
        <property type="gene ID" value="SPAL_0001112500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="926"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001112500.1"/>
        </source>
    </evidence>
    <sequence length="1430" mass="163340" checksum="A48D98D275B472A0" modified="2015-12-09" version="1">MAPPIETFNSSNPYLRLKTLRLALFKAQSEDKKKTTIFNCVDPSFFEECSLEEIEDLTASECYLKISKFYESYADAFDPYDKILLITDKLFIDFTLRTPYSSFFKDVEARLKFFKVDNFDALIIHKFLDLVTPRIRNQTWFKDVQPDDFCLESWSKAALTWDKHANSGLVKAFRNSYISNNTKKDVAKKEVDHAPIAPVGPSIASAQRAIFDTIYDYIMIDSGCKVNVLSKLTFDKLDPRTQSLCKFDDNFTVKLPNSTNATCIDITFCVFDFQWNLMGLDTCIEFKLLSKLESLLSNECAAIDVDSGKSDVSCIIKFLDNNPILYNDVITNSKITVNLPLPPSVTPFNAPLIRFAKDLKSVSKDILDSDVEKGILRKVPDNESSPWLSNAFTIAQDGKKPRLVINPKHLNSQIAIPSDIVRRLPTARDVFSLISKYYESGKSKDYCFSSFDIQSAYHNCRLSPDQAKFLRFKTEYGIYEPQTLIFGLNVSSHLFICELEKLMSGIDNIIFYSDDGLVVTERKHHPTVVINILSRLLSVGWKISVGKSVWMTDTLEYIGLQISPRGISIPDSKKAKFLNFSRPKSLKQLMFFCNSLNYYRSMIPEFSVLIEHFYSMKSFRWLDAEESRFKRILEILSQHTYLTFIPSNVDYFSVTTLVSERAVSSALYWHKDSNSGLFDLAGRTLSTSESNYLSQTKILLAAKEIIYDNHNFIFDIPIRILINDASLKSVLTKANEPTSAQTAFQRFRLFLECYNVEYIFTKTVDMFNKLRIENHLDEPTPICALQELIKDNALESIEVSDIVCSYTSDFPASLFYKVVASQDISDIELRQLSSSLRQYINTDNIFVDTDGLIKINNKIYIPSSYENELLKLLHKYHRSASAMMSLCKSQFILENYSTKINSYYLNCSICMMYRRSGPRKISTWPSCSQPRQRWHCDHLYFRNKYLLVITDVFSNFLILYHLPSLSVSTLREAFNCIFAQYGKPTILVLDNHPSFAAKEIKQYFLSHSIFIIYAIKYQHHSNGYAENMVGYTKASLTKLMVTENFKSAVNLTMLKNHSSPFHDSTPEKLFFKDNNLTSEIILRHTPDVKIINQRGMFKIKPEEKLWRPCLVEQKLGSDTFLVLDDDSSSHLLKSNCVNLNIGPALKSEILSSEPSNVNDALPPPPSNFPVDENVKKGSMTVPSPNNVDRRDTVESTTAHIIDEDNSMDISNDSVTSQSTLVFQSSTPASEKAILSFKTEHQFNDFLTLHPEYKTSFVFIDGSTKPHMKNPSAGLGYLVYIDSPIVIGGAVIDPPCTSDMAELKALLHILPFLSEVEKPLLICTDSSYIYKSIAYGWSHRLAIEEHRPHTIEWEAVLRLWKTNFKIVHVESHVRNSTFGIQTVDFMARAFSQRFLSDTYFKTNATTTKDALSAAKSILLDYEVKLRRKVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZV2</accession>
    <name>A0A0N5BZV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bro-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZV2"/>
    <dbReference type="WBParaSite" id="SPAL_0001129100.1">
        <property type="protein sequence ID" value="SPAL_0001129100.1"/>
        <property type="gene ID" value="SPAL_0001129100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001129100.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25386" checksum="A50F67DA7ACA8FA3" modified="2015-12-09" version="1">MVKRESYFYFTIAGFPVNVIVAKTTDYCYQNKLVYFQVRPTNYIGAFRILDFSEAKLEETEMHFKRLNGKIQIEGVGLCTFFFTEISEIKIQSDDDKVSIPHIVSYFKRNRLPELNITDAGDGRFYLYSKLPHNVMMVDHHLEGLKNKIKMPHFNRMIRFYRNHELTEGRTLERMAGRREQDEAAKTNIEETESRITAVEARTVMVAEPLRRLGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C121</accession>
    <name>A0A0N5C121_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C121"/>
    <dbReference type="STRING" id="174720.A0A0N5C121"/>
    <dbReference type="WBParaSite" id="SPAL_0001169900.1">
        <property type="protein sequence ID" value="SPAL_0001169900.1"/>
        <property type="gene ID" value="SPAL_0001169900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001169900.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13266" checksum="E17FB03E6C95C38F" modified="2015-12-09" version="1">MKPGETIVSVSYCQLIEKMHQKLSQKRPAVKLCELGYESLPHPPYSPDLSPTDCHFFKHLNNFLTEKVFRNDEDIKTASEAFIESRSPDFYINGINKLVSRWQQCVDCNGFYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C156</accession>
    <name>A0A0N5C156_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C156"/>
    <dbReference type="WBParaSite" id="SPAL_0001173400.1">
        <property type="protein sequence ID" value="SPAL_0001173400.1"/>
        <property type="gene ID" value="SPAL_0001173400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="144"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001173400.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46820" checksum="7B7DE2D6B1AD31B6" modified="2015-12-09" version="1">MDWRSQKLFPDYEINLGWVEKKMLHVFPENKWASAKFEPVTEAGFMSYLIRIIIEYEITNKNSSKNAPKKIFIKVPNYKGAIVAWESAGVVEDECAAAQGIGTVTLMTETEGRFYSLFKNKNYNLKIPRIFYVNLDTTDNKVQCLIMEEILDVTTVDVVEGLNKTQLYNIVDFIIQLQVLSFIENLDNPGAPPEDWNNLPITFNDYVLNARKRYMREFPKTLGPLIESVYNECFKGIEDTEATKDICLKYKPHMCFINHGDLWTSNILFDPKDRNTIKCVVDWQLAGKTTPFEDLTYILFSCITPELRRECQDDVFKYYYENLKASVESHGKSLPFNYQDLVEVFYEVLPHYVNRNLFAISIWTASPLCKTGKDDEEERIWRLNSRLKAMLEDVKEKNFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C217</accession>
    <name>A0A0N5C217_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C217"/>
    <dbReference type="STRING" id="174720.A0A0N5C217"/>
    <dbReference type="WBParaSite" id="SPAL_0001203200.1">
        <property type="protein sequence ID" value="SPAL_0001203200.1"/>
        <property type="gene ID" value="SPAL_0001203200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10809">
        <property type="entry name" value="GH38N_AMII_GMII_SfManIII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="11">
        <location>
            <begin position="492"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001203200.1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="137345" checksum="837D80EC876D2429" modified="2015-12-09" version="1">MEKIGQELLQLKKDADIRIDKLREEIKEETKLINFYKEKILELEESIKENSKEGFENNIVKPIVIDKIVNKDIEIEEHIIKDEQKVLKEPKIINESTSSKRSLKSCKSNIKNLFSSDSNDVQMLNVYEKIPFKNIDGGAWRQGWEITYDKSKVSSEPTLHVFVVPHSHQDPGWLETFEGYFDNKVDYILSSLSNFIVNNDDMRFIYAEMSFLERYWSRKNSTEREKIKKLVKDGSIEIVTGGWVMTDEANSHYFAQIMELFEGHEFLKNQFDDYKPKNHWSIDPFGLSPTMAYILKKSNLTNMVIQRVHYEVKKYLAERKELEFNWRQLWDNGEGKTDIFTSMFPFFSYDVPHTCGPDPAVCCQFDFLRILKYGCDWKINPVRIISKNIQERARLLVDQYRKKSQLFKHNVLLIPLGDDFRYENKEEISIQYDNYKKLFDYINSPEGFKEFNMKIRFGTLKDYFDAVNRKFEEEKPATLSGDFFTYADHDDHYWSGYYTSRPFYKRLDRLLQHYLRGADLIYSTSVMSYSKNTNILENYKKKVNYSMLVEARRYMSLFQHHDGVTGTAKSFVVTDYAEKMLKGIENCFSIIQNSLEFFLKINTSDAKIVYENNDSKNDHVVKLTVNEYMESSDTLPSSYVINQNTSLVVYNPLSREINEVICVKIYNYDMRIQNINEEDQEIRPIIKVWNKQLTFTNKSNSRNIKRNYFELCFKVSIEPLGTKVYNLTKKRLPKESFCKIKGSDINVKNIDISGSYLKDEYGNDIFDIDRVNKNSEQRVDLKFDSISISINDKTGFLSHINDEVVEVSFSKYGVRSPIPSKPGGEVVSGAYLFLPDGPSTKLSSNENSYIILDGKLKKTVFVKGNEQTQLFHKTEIIESKLYVSITNDIGIMDLFDFEMAMEVNSKINSEDIFYTDLNGYQIIKRKRFDGKIPLQGNFYPMPGVMYIEETKNSGKRLSLIGNQPLGCSSLSSGKMEVILDRRLTHDDSRGLASGVLDNVKTRSSFRIILEEMEKDDTSNRSPTGFLSKIAQLTYQQMHYQPIILFSKTLLNIHESILKRFSPLKESLPCDYHIVAMRTETEKCDYEKRENGGILYNSKNSLGLILQRYAFDCSLSHKNTQSDDKCIESEGKVDLKRKINLESAKIYNSSLTMMYSEEEKEIEEVELTPMEINTFKIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2C5</accession>
    <name>A0A0N5C2C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEC14-like protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2C5"/>
    <dbReference type="STRING" id="174720.A0A0N5C2C5"/>
    <dbReference type="WBParaSite" id="SPAL_0001213500.1">
        <property type="protein sequence ID" value="SPAL_0001213500.1"/>
        <property type="gene ID" value="SPAL_0001213500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058960">
        <property type="entry name" value="Ctg-1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25883">
        <property type="entry name" value="F28H7_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="84"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="275"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001213500.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45880" checksum="328A26E6CC2ED0C3" modified="2015-12-09" version="1">MPYSKPASINITNPDVTRSPSSEELQMVTDMRTVVPTLKDIDDMYILRWLRSKDGRFDETSEGLRKNMLFRKAWQLDNIDEWVPPECLEKYCGYGYLGDRDGFPILMSLLGNMDVDGMLRSVQAVDYIKFSLAAIEKGIQLADNKAKETGKAFGQIMLVFDLDHISSAHYSCKRFASSFTTLVLLFQEHYPLVLKKVLIIRAPEMARVAFKSMTPFLSQSILNLIDMPGEESWQNVLENYVNIDSWPMHWGGKMVDDNGDPKCPQIVRYGLGPIPDSFHVDPNTAMPDYDQLTTVYAGDKHLIDICTKKKNTKIAWQYMTEEDDIGFAIYYDETASKNNLSEMDAVYPYIRLECSLVPISGSFVCERPGRYIIEFDNFYSWFSPKQLKYTIDIIDDDCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C349</accession>
    <name>A0A0N5C349_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C349"/>
    <dbReference type="STRING" id="174720.A0A0N5C349"/>
    <dbReference type="WBParaSite" id="SPAL_0001240400.1">
        <property type="protein sequence ID" value="SPAL_0001240400.1"/>
        <property type="gene ID" value="SPAL_0001240400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000070">
        <property type="entry name" value="K+ channel tetramerization domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF133">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="87"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="235"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001240400.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59451" checksum="B3EE2AEAD13C1D11" modified="2015-12-09" version="1">MRGCHTTSLYNSTSFGIGEQQDLVTGNMISGAAQQHKKRMIPLKRTEAMDTADRNTGKLLDDVWKNGGDCYQVIQSVDEDKSKPSFLKLNIGGQKYLLLCDSILRNDASGFLSKFVQLKHPSRCKVADAYLEDEESYYFQRSPLIFDCIFQFYASGVIHKPPEICAASFLSELDFWRISTSYVGSCCADIVPKEKIEEREEEKIDDNTFDKLRFGKLRRRMWTFLSRPGSSGQAKFFELTSTLFVAISVLGLSFGTIPEFQVTQYMPPHNETIVLPNGTVTVIEKVEEMRVEHPAFVFTERICIAFFTVEYCLRLFAAPRKLHFMLKPLNLVDLMAIVPFYLELLLTLCGVDDKKLRDLRWAFLVVRILRVLRVIRIIKLGRFSSGLQTFGMTLQRSQKQLQMMTIVLLTGVVFFSTMIYFLEKDEEGTPFTSIPAAYWWCIVTMTTVGYGDSVPSTAMGKIIASAAIMSGVLVLALPITIIVDNFIKVAQDEQQAEQMKEEQSRQDELIKQMISKTNCTNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3G6</accession>
    <name>A0A0N5C3G6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3G6"/>
    <dbReference type="STRING" id="174720.A0A0N5C3G6"/>
    <dbReference type="WBParaSite" id="SPAL_0001251400.1">
        <property type="protein sequence ID" value="SPAL_0001251400.1"/>
        <property type="gene ID" value="SPAL_0001251400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01240">
        <property type="entry name" value="PH_GRK2_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08747">
        <property type="entry name" value="RGS_GRK2_GRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000118">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000068">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="13">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="191"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="455"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="557"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001251400.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="81047" checksum="5195197A9EE66856" modified="2015-12-09" version="1">MADLEAVLADVSYLMAMEKSRSQPAARASKKIILPDPSVRSIMQKYLEKTGEIRFEKIFNQKLGFLLLKDFAENVSDNACPQIKFYEAIKEYEKMETVEERLLKAREIYDHNIMVEMLAHSHNYSKESLQVVQRNLMKNNVPPDLFQPYVIEICNQLKTDVFPKFLESDKFTRFCQWKNLELNMQLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKLKQGETLALNERIMLSLQDCPFIVCMTYAFQTSDKLCFILDLMNGGDLHYHLSQHGVFSEDEVRFYAAEIILGLEHMHSRSVVYRDLKPANILLDENGHVKISDLGLACDFSKKKPHASVGTHGYLGPEVLAKGVAYDSSADWFSFGCTLYKLLKGHSPFRQHQKNNKQDKNEVDRITMTQDIELPDQGFTPDCRDLLEGLLKRSVDERLGCKGKGAFELKTHPFFKDIDWQVVFLRRLTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLTEADNELYKNFNIIISERWQQEIAETVFDVVNQDADKLESKRKSKQKSRMNVEEKDSDVIVHGYIKRLGGPFTSAWQTKYGKLYPSRLELHPESLGGKPELVFMDQIDELVPELQTVKGENCIIIKLKEGFKETKVILTNQDEISLKEWHTSLRTAHRVSQELLQRMGRKAIKIYGVNHDPMLQEQERTNSVTRALLNRATSVDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C402</accession>
    <name>A0A0N5C402_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C402"/>
    <dbReference type="STRING" id="174720.A0A0N5C402"/>
    <dbReference type="WBParaSite" id="SPAL_0001268500.1">
        <property type="protein sequence ID" value="SPAL_0001268500.1"/>
        <property type="gene ID" value="SPAL_0001268500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001268500.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29484" checksum="224DD4E14A19DCFB" modified="2015-12-09" version="1">MLKNIFNIACTRRLTYFASNLPNSTGILPPNINISNLRVPIDKPIVNEDKSCVLPGYYHNVKIYSFPELNPKIVEAPTLQNILDKIDPSLNEDASKEIGEPNKSISPLYCTPRIMTIRKKKMKKFKRRKRYDRDFYKYQKYHHQKKIKAERKFRQQMALLIKEMEDFNPMEYVNKTIETAKLEWSSTVAPSGKKKYPHWSQLMEVEELYGITKEKYIDKRYGYPTEEDAKKLEYMTKEYLEGYCKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4P1</accession>
    <name>A0A0N5C4P1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4P1"/>
    <dbReference type="WBParaSite" id="SPAL_0001292100.1">
        <property type="protein sequence ID" value="SPAL_0001292100.1"/>
        <property type="gene ID" value="SPAL_0001292100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001292100.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="40505" checksum="099B6B01DEC9BFA5" modified="2015-12-09" version="1">MKVNKIDLHNLLANLIDEKSRTVAEFKMAYHSNLCEIKNGNFEKLNLLIRDFAYHLNVVGHLEMPITMDLTRCIGKFFCQQLQLGDINVTNENLVKLNNLIKNLKRREVKPLKQLKESFLMRKKMKFEEEDDEQILKNICERKYEGLAEILTKIKSKRINFNNLEMLKKVLMYDNDLFVVLDNLFMPFNIIKKFLQKVMSFVYTLSEQDFMGELTYIRFMLMNSRSKDFDDSFYVEEYITSTDALYILKKEGKFSIHCREEEIFLCNNLEEALYLLTILKGYFKVHVAKIHTRIIELFFIEANLNSEEVKGENQNYLVCVMELYDLVTGRSSDNNNNVITKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4S0</accession>
    <name>A0A0N5C4S0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C4S0"/>
    <dbReference type="WBParaSite" id="SPAL_0001295100.1">
        <property type="protein sequence ID" value="SPAL_0001295100.1"/>
        <property type="gene ID" value="SPAL_0001295100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="258"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="509"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="692"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="903"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1344"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1376"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001295100.1"/>
        </source>
    </evidence>
    <sequence length="1477" mass="169766" checksum="B99A244545BD9125" modified="2015-12-09" version="1">MSKIAFPFEQFANWTPYPSNQSTLTQSESQTVTVSDGVIIKAKSIFVERVYQIFNQVHPTLIIDTKSVAYICLLLARLFFELIETRPNTREDIENRINNIFTPTMCHWAKKHIQTDKITKYKNGKKLAQDKSLESKTRFELFQKISRLAKENLGYKIPETASLLILSIVEYVAHDVLQWGGSFAKNIEGAKHIVKNGKRMLDYNNLKTAIKADANFSDFQAYLLRNCKDDETLLIPFENQSKEKDFELFDIVKNEEMCYDKVLKSMVEDISRYIRDLNLLLNVFKRNMETGFCYYKLENDYIKKCFGNIEEIYNLTLKVQGVLEDSFEMLNMYNVGQGLIEFVEGLDFNCYYDYVNIFQVPTDFFDCMIKDENLQEYYDHEDQIYRNTPNGTPFRLAVRYILPELLKSPIKYFFRFTEQINLLWKYSMSDEDENDLGSCKSILIGLGTQIEMQASRMVNFNLKNDIQTAKTTPLSDNKIMLHKKDMIMRDIQSKIEGWQGANIVATSTRYIHEGVLMKIRHNGSSVTETIKGKFGSAERYVFLFDQTIIITKKLNQPKTNNATISVAPTDSTIEYKFKDQIKLKASDIVDLEDNDEYSNAFKITSYSSCNNHDGMVSSILILAARSKEEKEKWMFSFADALSSTLLDRILDAFLKEESIRIPLYFPDPKIYKFAEPNREDNIQFEDYTHSNGAHVVKNATLTKLIERLTYHKYHEPNFMKTFLTTYRSFCEPIKLLNLLIQRFNVPIPKELSSKNVNEKEKTNSKTSGNLLIEQAYNRFKKEYQRPVQMRVLVVLQYWIKDHWYDFENNNEIIERMMDFLDGKCCEQAFTKQQKSMCHTIKDSFSKKKRNNFVNEKSFDSDVGENESSSNSPAASSPGIIKYQHFWHTAKKDDINDYNLLTLHPVEIARQLTIIQAELYKAVKPIELCNVAWTKDDKEKRSPQLLKLIQHSNQLTYWIQWCIVNERSLEDRVAMYSRVIEIICVLEELNNFTGVVALFSALNATSVHRLAHTRQRIDKEKIAAYERFTKLCDSHWVEMSQRLKTVDPPVIPFFGIYLSRIVFFEEGNKTFIKRKNTSTSGNQEDQKADNDGVSEDNNNDKLISFLKCRKIASLIRDIQMYQDKPYDLIPEPSIKAFFENIDIIGKFPDKNSLEHCLFEQSQLVEPKDAEKLEHIKSNYSAATLKSPGIKIPKTPTPIPIVSPKTMVMSNPQPPPSPSIASTVQQSEENDFAIINIKPGTFPKYLGDAPTKSNENKFFNHNLSPKAFKNLAARLNQRALSNMNPYHPILDGPDHVEIDESYFCSPSPSAYTQDGAFIFPPVGSGLTKSFPVEVPTVFAPKIKERSKVAKLSDTVPQTPPRIIPRTSKSGTKPKRESNSSQHSPVHLSDLNSSCTNTDSNESLGERVPSPLLTTMPMRSRAPSVISCKSCGHTYEPPTPPGELEDFILNNEQKTSINNLSTTINIPPPIPARQTHPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C590</accession>
    <name>A0A0N5C590_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">28S ribosomal protein S6, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C590"/>
    <dbReference type="STRING" id="174720.A0A0N5C590"/>
    <dbReference type="WBParaSite" id="SPAL_0001311700.1">
        <property type="protein sequence ID" value="SPAL_0001311700.1"/>
        <property type="gene ID" value="SPAL_0001311700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001311700.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18864" checksum="F939CDEF962F4ACF" modified="2015-12-09" version="1">MPLYEVTLIPKHLGKTEMFNVLKRGVNLLLDHGAVITEMKSLGHRDLPFKRIAKQTKEPVRESTYLLLNAYMSIQKRSEALKLLSNDLDIAYAFFVNTKDLDKPIPECNLDDMLKPPVYRESVKALRDDGKIGHFTRQIIYKRTEKEWKAVPKSYPIPPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5H5</accession>
    <name>A0A0N5C5H5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5H5"/>
    <dbReference type="WBParaSite" id="SPAL_0001320400.1">
        <property type="protein sequence ID" value="SPAL_0001320400.1"/>
        <property type="gene ID" value="SPAL_0001320400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895391" evidence="3">
        <location>
            <begin position="19"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001320400.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="87055" checksum="1612A4EBAA5AAF8D" modified="2015-12-09" version="1">MLVKLLPILLIICETIQGQYSIFGTPKGRNRILFTEHNCRKPLTTSLLYHEESIIAFNTLDKYQTNLKQHANVKFEEVRIYPLSWDHIKKNSRNLYKLCGLALAPTKQKEEYINGNLTAIGVKDNYEISYSTGYYLGNNFDDYRYARIWCNIQQCDMGLFFFDENKNAAILNNVKQNYTVDYAVLIVIESKDNKMLLGIKPHHKVNIRLGLCPYIRWVSEKGLFKFKPEDHIKNMGYFDYGNSFAHIVVPFYKKSGNLNEFICGKLKQLALPDLLIGYALREDSESIQTSEDINPLNDELKCKPGDSISNHYHFGYMETDTNYMSERIMEPIKVRNGTSPYNFYAGQKIYIYDSAKFKHALENRNDHERLRDPNVIDVVLCIKNLKSDIRANILPSIGSVESIKKHEGKNIFYRLIKSDELDNKYPFRCLTKTVDANKGHMEEFYSRSAEFTIKNEEDPNVVYTSSQNEINFKRKKINNYGSYRCKDVKTTPLLIKDIVTMDKVYYLPDENAEMDLLHSQVADTYQSDIGCNKQYGTFGKIKKMTVKFGQDVRDPLTIDDFSNGTDIIDIKEGKILYKVPKDIPGVTVICIYETPVETTFYTTKDFFISITQDSGTKNNETKTITKEKIVTQVKNNSTPWVIGIVIAVILFCIIVIVVAYLIVRRVKKRRAEDSLSSYSGLSTLSKSRSKGSTSMSSSKSRTRGESRSASMSNASKTGKSGKGSRTGTYSSNVTSNVSRNSRSSASTNRGKNYFKNVNLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C632</accession>
    <name>A0A0N5C632_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C632"/>
    <dbReference type="STRING" id="174720.A0A0N5C632"/>
    <dbReference type="WBParaSite" id="SPAL_0001340700.1">
        <property type="protein sequence ID" value="SPAL_0001340700.1"/>
        <property type="gene ID" value="SPAL_0001340700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340700.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="60234" checksum="7F2BFD9574448A0F" modified="2015-12-09" version="1">MRHFNQKPLVLPHTIRTNNSLIVLNELIGQGGFSNVYRGVKVLNTGSNICAIKIGQNLSHEQDVMNSLLTKSELDKFFPDGYCPLPQVVDTGYDVLNSFFFITMNEYPMSLNDYMINYLQNGRMDLHDVNDVTKNILDGLYFLSKRGVIHQDIKSKNIMLKEKDNLNCCVLIDYGTAQLVDFTGKKDEVNGKIMEESIYITPMYSAISIHEGSKKSFKDDLQAFFFNTYEWLTGELPWVKCEQNYAEIYRMKKEFYYNFSEDNNLSFKDNNFLLLLVNTIRNLKLDEIPDYMNLKLTLNDITLSRIEENKMECSTDPLDKNETGFYTLDVTQYFDVVSKMEKISLDDKITLKTLKNPLDVSNVIRKTRAVGLLMHFEKMRVRGFVYAYRTCWSTGTTGSENLDNYARKRLNYQISPLQSLLRGLVSLIKMFGDKNEKEMTIVIVEPVLFSFLKSLHDDKITGRGKNLVDSLKNVLRDYRNVIENVDKLRIIFAEVNGYVKTIQDTRELAENAIQYFEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8G5</accession>
    <name>A0A0N5C8G5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8G5"/>
    <dbReference type="STRING" id="174720.A0A0N5C8G5"/>
    <dbReference type="WBParaSite" id="SPAL_0001421200.2">
        <property type="protein sequence ID" value="SPAL_0001421200.2"/>
        <property type="gene ID" value="SPAL_0001421200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="429"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="678"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001421200.2"/>
        </source>
    </evidence>
    <sequence length="1109" mass="127919" checksum="1C2B428897EBB7C4" modified="2015-12-09" version="1">MLFKNAFFKRVFSIIVSKYRKQDLRENILLRPDSYIGSTKDITCYQFLFNDETNKMMRSKVSYVPGFIKIFDEILVNAADNKQRDPNMTSIDISVSDYEEIKIRNNGKCIPIQIHPTMDLYIPTLLMGHLLTSSNYDDNEKRIVGGRNGYGAKLCNIYSKQFSITCFDSKNGKKFSQTWYDNMSKCDVPTIEEVQHSNSEDYTEVSFIPDLSRFNMKSINNEVINILRKRAFDVAGTCDGIKVSFNGDLINVSNFEEYVNLYLLEMKETLKVFKTNRWEIYISQSLQGFQQVSFVNNIATLNGGSHVNYITSQIVKHIKDLLKKKIDVTRLKNFHIQSNLNVFIKCSIENPSFSSQTKEELTSKISEFGSKCVIPNSFISDFLENSTIPESIENSTKRQSVGTTKKAKIVFNPKLEDAFYAGSDNSKECSLFLTEGDSAKALVIAGLSVIGKDYYGVFPLKGKIINVRGLSFNDSMKSDVFRNIVEIVNLKENVDYSQDHNRNSLRYGKVILFCDQDFDGVHIKGLIINLFHKFWPELVESGFIQTFKTPLIKVTRGKETFKFYSKFDFDEWLNKRENKEDFLKCKIKYYKGLGTSTEEEAKEYFKEFDRNLITFTCNSENDHSSIKNAFSKTSTSDRKEMIQNHTSTGTSDSNSLPISTFINSDLVDFFKYDIKRSIPNVVDGLKPSQRKVLYTMFNKKFKNGKIKVNQLAGITADFSLYHHGEDFLTSTIVKMAQNFVGAENINLLEPDGQFGTRACGGSDSAAGRYIHTFLNPLTRLLFPKEDDKLLNYTEEENQITEPIYYVPIIPMILVNGGKGIGTGWNTFVCPYNPVDIINNIRLMLDEKEPIKMVPYFRNFKGSVTETKVNGSFEIKGVSKIFFNDLENTLKIVITELPIGLWTDTFKEKILQPFHEKKILKSFRDLTDDNNIEFQIILSKEKNVPIKLAKSLKKLVNTKSMVLLDGKDNLKHYKDRNEIFEEFFNIRKNLYEKRLLNEINILSRQLLIYKNQRDYINNILSNKMSLINKSKKVMIENLKSKGFCPNPLKENSNDYDYLTNISLYQFTDKEISKLEQKIAEESKKINSYKMLTWKDLWNNDLSKFEASYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8Z2</accession>
    <name>A0A0N5C8Z2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8Z2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0001437500.1">
        <property type="protein sequence ID" value="SPAL_0001437500.1"/>
        <property type="gene ID" value="SPAL_0001437500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15934">
        <property type="entry name" value="7tmC_mGluRs_group2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06362">
        <property type="entry name" value="PBP1_mGluR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895563" evidence="14">
        <location>
            <begin position="18"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="629"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001437500.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="108564" checksum="65D1B73B9997FDE7" modified="2015-12-09" version="1">MFTLLALVTQILTNLQGYTDYYNDSIGPTSNNHHPAIRQIFFDGDIILGGVFPVHGKSSSENFPCGDIYETRGIHRVEAMLYAIDMINNQADFLRGYKLGAHIIDSCSNPAFALNQSLDFVREMIGGIEGNEYECGDGSIPVLAKPHKKNVAAVVGGSYSSVTVQVANLLRLFKIVQVSPASTNADLSDKSRFEFFARTVPSDTYQVRAMIDIALHFNWTFVSLVYSSDEYGELGAGAFKKEARKANICIAIEERIRIKKESIKDSVDNLIKKLEPDKIVGASVVVLFVGTEYIPVLMAEVSNRMGINENNYNEKKKIIWLASEGWDRNNEAYTAGQRKWAAHSAIVLMLESQRIPSFEEYYLSLHPGSKKFERNKWLRELWRNKFTCEFDLPPDDKRERCEDKKQSHEHFSPDDKIQFVIEAVYAIAHGLKKMKEKHCPNDTVEYTWINRYSKNPELCFSLRHIDGEDFYKNFLLKLEFNDLVGKKVHFSKEGDGPAQYTILNYQPTNGRIVESDRDDYVEVGRWAEGKLEIHEEKMFWNRKENNKNIKDSIPISQCSMPCPTGHKKQLIKHDELCCWACSKCEDYEYLSDEATCTDCGLGRWPKDNRLECYDISSVELKYMRWNTWYTIAPVIISCIGIICTVFVIICYIKYSETPVVKASGRELSYILLFSFILCYCMTFVLVSMPSPIICALKRTGIGFAFSCLYSAMLVKTNRIYRIFSMATMSAQRPRFISPISQVIITSILAGLQLTGSLIWLIWVQPGTKHYYPTREQVILSCNVPEHHFLYSLTYDAALLVMCTVYAVKTRKVPENFNETKFIGFSMYTTCVIWISWIFFYFGTGGNFQVQTTSLCVSISMSANVCLVCIFSPKLWVIFFENGRENNNRQERDYMFKGQNTFKYRSSNVDEFSSDVPNASTALLGKTTKRGSRNSSCRPSSSITSSAQDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9V7</accession>
    <name>A0A0N5C9V7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9V7"/>
    <dbReference type="WBParaSite" id="SPAL_0001468400.1">
        <property type="protein sequence ID" value="SPAL_0001468400.1"/>
        <property type="gene ID" value="SPAL_0001468400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001468400.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65221" checksum="25BA9E6FAB7AF1BA" modified="2015-12-09" version="1">MSDKTGDIKENLDSKVNEKEENRNIKNIQKNENYNRYQNNDTSLALRHHMKLFSSMYNGNDDLSLINTDSITDLFSMDDNYSKPTSTVCSSTSNIKATDDGLFLNDELNETITSSDNNLLTKIGNKSFLLEDSENSFLSTQKHYIDHLKTVNSFNVSTTGQTNGNEEIESKNNGISSQNRKAIDDLNIMIAMEYANNELPMTMANYRPGGCNQNEMINNFKKVDEYYNSNVCLSDRLSNFTGNGDTFSDSETNEEDKLVRWMENRELSAAKIGMILSFLDSPQCIPPNIELNPDTGMPLPQKRSSKNNHPIDNNTSEIGSQTDISLSGSFQHYHYPMKLGPNSQYSFSKNCKLNLDIPKTPEDEKKVFEVLIFDGKGVTREKFNVIYAGLPFKTICLGPSQSYNPFQNHAIESETGERYYIDSMDDSMFSGDVDISIDKNYNVNIKKACNCICRFHCSIYDSKIESEDYFYFLERSNVRIFNKERFDKILPGILDYAKLNNWNISMLKKYATVTISFVDSREPDCKDISRTGVDKDSLPCFHKGSYMEIIILPIIDIINEKYMEICSQSLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9X2</accession>
    <name>A0A0N5C9X2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caenorhabditis elegans ly-6-related family-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9X2"/>
    <dbReference type="STRING" id="174720.A0A0N5C9X2"/>
    <dbReference type="WBParaSite" id="SPAL_0001469900.1">
        <property type="protein sequence ID" value="SPAL_0001469900.1"/>
        <property type="gene ID" value="SPAL_0001469900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF4">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895594" evidence="2">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001469900.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25143" checksum="D56D7CD88287E763" modified="2015-12-09" version="1">MLTFHWKEILLFLYLFSWIGFVDSAKHFTGYLHQGSEDRNCYSCMSEEFEKHWSYLEKVYYRPLNFTDHCHTMPNYARIGIQECPHSLCVTVIEPKILAGQQIGSNVIRGCFSSVFRHGDMLMGSVNKHNVLDTRCNNISAKKLLPPHLSKMSSNRMVDVCWCVGQLCNDYPSINSGNSNKNLFINTRMSQYSQKISNFFPTQIALIISAFILIIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAM9</accession>
    <name>A0A0N5CAM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAM9"/>
    <dbReference type="WBParaSite" id="SPAL_0001494900.1">
        <property type="protein sequence ID" value="SPAL_0001494900.1"/>
        <property type="gene ID" value="SPAL_0001494900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001494900.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14682" checksum="07122F921985D466" modified="2015-12-09" version="1">MKYSALVTGICLAIFIMMANGYLDIMSLKNNHDNERINGWKLLPDFLKQDSLLNKFQYIPFSQLHRRYNNRVPSTNSRDIERYERILSLNDLQISNIQIITNPKQTNYTKTNCFLSPVQCSFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBK2</accession>
    <name>A0A0N5CBK2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Syndecan domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBK2"/>
    <dbReference type="WBParaSite" id="SPAL_0001526800.1">
        <property type="protein sequence ID" value="SPAL_0001526800.1"/>
        <property type="gene ID" value="SPAL_0001526800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895708" evidence="3">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001526800.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22054" checksum="371ED85472365EA3" modified="2015-12-09" version="1">MLNIFYISFNIFIFLFLIKGEENISSPGEAIKLNDGKLTTIGDNKGNPSTLGVDTNSLINTTPVTHANTSISSTNFQDISRTTDVPTLDSNKVNANDSIRPSTTSENLSESTTTKHFNNSPIIDGNLSNNTTIIDETKSSNKTNSASRGHGEVISNVAFMAGILTLLFFLIVSCAIFYRYFHRNEVKQTPAKNMMALDEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBN2</accession>
    <name>A0A0N5CBN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBN2"/>
    <dbReference type="WBParaSite" id="SPAL_0001529800.1">
        <property type="protein sequence ID" value="SPAL_0001529800.1"/>
        <property type="gene ID" value="SPAL_0001529800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001529800.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34787" checksum="DC1E09F749CD414D" modified="2015-12-09" version="1">GKTTLPPRPPPKRPSGRKTVPPKNKRPTPKPTTGKTTTKNNTTRKLSTSRPSKRPNKTSSRPVTKASSRITTKKPVIPAKKPLKPTKRPAKTTKKHERTTTTSTPSTSKPTFPATITEASSISASTSPISTTNPSTFTETLSTSSPTSPISTTIPPTTTQNSDIYANEKDALINEINFARQLHRAGEVTVNDELAKKAQELTDESALKRQFVPFKNDTVGLLTYQNREEYNEDFGFSRWTAGADTFDFRKPENNLHHYSSFTQLVWAESKNIGCGISKNERNEIFVACLFYPKGNIPGKYSQNVHEKDPDYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBV2</accession>
    <name>A0A0N5CBV2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBV2"/>
    <dbReference type="STRING" id="174720.A0A0N5CBV2"/>
    <dbReference type="WBParaSite" id="SPAL_0001536600.1">
        <property type="protein sequence ID" value="SPAL_0001536600.1"/>
        <property type="gene ID" value="SPAL_0001536600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001536600.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35807" checksum="BBB1F05668167033" modified="2015-12-09" version="1">MTDSVSSAILQSNPQLISYNTALNGVPGLISLQGSELLMYPNARATGYSAIPGTHYSLSPDLSALQVISKQSRDVSYDTSSNDPILRRSRVFVGSLNSMIVKRPDLITLYSNYGTLLGVTLFKNYAFLQFSSPHEADSAVAHTNGLFFQGQILDVKLAIKNMKNPSRGTPDTTNAKDESRSLKRTSPTPSETSDETVLDVKKRCIEGINGENHIAATLEASSARINFYDHGMVDTLICGKCRYVTSSFTDFREHRKRPCPSLEKSGNRNERLQCMTCCSVFESDSDLINHLSVDHNMALYRRFDDHSPASLVEETGGCKEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC93</accession>
    <name>A0A0N5CC93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM120 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC93"/>
    <dbReference type="STRING" id="174720.A0A0N5CC93"/>
    <dbReference type="WBParaSite" id="SPAL_0001550200.1">
        <property type="protein sequence ID" value="SPAL_0001550200.1"/>
        <property type="gene ID" value="SPAL_0001550200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="982"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001550200.1"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118770" checksum="78C4D05A119F2927" modified="2015-12-09" version="1">MVDGRIFPPFIDKDDSEYIPEGDIEYPFEDISGSGDENKIRGNWSSKAEYLVSVTGYIFGIGNLYRFPYLVSKYGGVSFIVIYFIMFFLAALPVVFIELSMGQFISLGALSIWKVVPLFKGIGISMLFISFFFGIYYNVIASWSIYYFVNSLKFQLPWATCVNGWNSKSCSVWNRDFLVTCTEMNGTVLLNGTCSNSLVDINTYGNQSTTTESNLWTTSQTMPALEYFHNQVLMISDGIDDIGIINWQLAICLLISWLFVFLFLFKDIKSAGKTAYIIVILPYVLLFVLIVRFLTLPGSLAGLEHFFKPDWSVFKNPMVWGQAAVQVFYSLSSCSGGLITLSSYNRFHNNVFKDVWVLGLIDHVTSLMTAALTFSAIGFMCYEMNININYFQWKTGLQLIFVFFAETLSRLPIAPFYAALFFLLVFLILLSSQMFVVETIVSSICDQFPERLRKNHRHVLTFVAVLFYFCGLPLCSSCGLYWILLFEYYICQWPLIIIAFFEIMSLSWIYGIDNVLDNIRWMIRFYPPIYLVWKIVWKFLTPFVFLVILTFTWIEFKPMYYEEYRYPYWANLVGWGLSLMPILFIVSDGMVQFCTVKGNFTKRWRDVLCPENDWGPALAIHRSEYYPLQIPEARGLLIQKGERIRSESPSTNWLNEKQSSFNNIGNGLENGVKKSPSPDITEALEDWDSVQKELVEAEKKHVTYMSTLRDLKKLQDECLKHTKHISKRLKDVSSEVKSIKGNSNYKPSEEENEKINSIISLTPETTSRLKVMESELPAEGNGWYLNLILGSNLKLKLLTGDERYDYKRKYEDFKINVSYIIIIMVILALIFPFRAMDALLNFLLVWYYCTLTIRESILRVNGSHIKGWWLLHHYVSCVLCGIILTWANSECYKDTRIYLLGLVLYVASVQIMQYSYQSGCLRRLHALGQRHCMDITVEGFVSWMFKGLTFLIPFLLVGYILQLLISYELFSLYSQEKCNREWQIIASSFVFFTIGIGNILTLGRVIYKKLKESTSETRILKAKSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCY6</accession>
    <name>A0A0N5CCY6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCY6"/>
    <dbReference type="STRING" id="174720.A0A0N5CCY6"/>
    <dbReference type="WBParaSite" id="SPAL_0001573400.1">
        <property type="protein sequence ID" value="SPAL_0001573400.1"/>
        <property type="gene ID" value="SPAL_0001573400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001573400.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13533" checksum="6A35CE4FF004FEE9" modified="2015-12-09" version="1">MAPPTASKGKKAVKSQKAVRPTDKKGKRKARKETYSIYIYRVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASKLATYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD08</accession>
    <name>A0A0N5CD08_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD08"/>
    <dbReference type="STRING" id="174720.A0A0N5CD08"/>
    <dbReference type="WBParaSite" id="SPAL_0001575600.1">
        <property type="protein sequence ID" value="SPAL_0001575600.1"/>
        <property type="gene ID" value="SPAL_0001575600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001575600.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="79227" checksum="3A3D37E2787BF8EA" modified="2015-12-09" version="1">MSSFLDTSSISYGKGGKSCIKVGIRIRPRNLKEIDENDPLVLCIVEPSTIILTDEERERIYSGYDFVFDECVTQCQLYKEMVAEYIPQLLFGYNCTIFAYGQTGTGKTFTMEGNYGDLNDCDSFKWDSDNYVGVTSRAMQHIFTILNLSQCIRKKVTVMYIELYNEEVYDLLGNDITRKLKIFEDNQNLGSVYIKDVKECEVNNMHDVNKILQHGASMRQTATTSMNQRSSRSHAIFTAVIEWDEITNEGTITRKGKINLVDLAGSENIGKSGATKGSAREAGNINTSLLALGQVINALTEKNSHIPYRSSKLTRILKDSLGGSALTCLIGAVSPTFSNKGETISTLEYGLKAMNVENNIRANVRARRDKYFPAYSILNDYLQSINGHLRNYSLGTHRNKLLSIVDKDLFSKIDNFILKRDDISEEAHKWLAADRDFLCNFGKKVDFQTKLVNEGKLSVINLKSKIKLLKNEVEVKLRKLKKLEEKSNNSIKTSQSCQNELSYKTNIFEEKILQAKELLQKRQNFLEEHLRNIHQSLAMCETMNEETIFKINAELKKIEVECKSILSDLMKENDDVVDNATETAMNILSSIKKENELISIAEDSQDKLIKSFNIKRNKFNEIISSKFKELEEIENLNVYNISSCDKRLKACNKIDEDIELINKYTEEIRSYIRTPEKSKSVLLLEEYIVELDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDD5</accession>
    <name>A0A0N5CDD5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDD5"/>
    <dbReference type="STRING" id="174720.A0A0N5CDD5"/>
    <dbReference type="WBParaSite" id="SPAL_0001588100.1">
        <property type="protein sequence ID" value="SPAL_0001588100.1"/>
        <property type="gene ID" value="SPAL_0001588100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001588100.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12182" checksum="0C5DD4B0AC5FEB44" modified="2015-12-09" version="1">MSLNPIQRKRSSNSPISGEENFSTNDYALKRHRNNIAVNKTREKKKLEMSVTSEKMEAMRAENAELERHVEKLKTKLATLKEMMSVYNKNRQDTKTISQPEKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEY0</accession>
    <name>A0A0N5CEY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfur globule protein CV3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001641800.1">
        <property type="protein sequence ID" value="SPAL_0001641800.1"/>
        <property type="gene ID" value="SPAL_0001641800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005896022" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001641800.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10553" checksum="4CA883E47DC69AE5" modified="2015-12-09" version="1">MKTLIYIFAILLLLTSTDARGWGRNWGGGYARTVTYRYWGHNNGFNRGWGGPGYRPFYGGYRPFYGGYRPFYGGYRPYWGNPYWGMPFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF32</accession>
    <name>A0A0N5CF32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF32"/>
    <dbReference type="STRING" id="174720.A0A0N5CF32"/>
    <dbReference type="WBParaSite" id="SPAL_0001647000.1">
        <property type="protein sequence ID" value="SPAL_0001647000.1"/>
        <property type="gene ID" value="SPAL_0001647000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001647000.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="62159" checksum="EB8EF60705E4AC50" modified="2015-12-09" version="1">MNFMLLKYKVVVLMSSSIFLPLNVSILLVIFKNIKKRMKRSSMKIAKKFPRNYMSFRNFLFKEHCYEKILNNYQYDIFENYSSVIPVYVEQEVLAGEFCKDINTPEIFAIGLHDGTITVGNANKSNKSISENCLCNNLSKHRTHVNALSFIKNDSRLISISSEDPVYLRDINTETPLESFTTNISLLKCLALNPVQQNVFIVGGRDNSIAIFDIRSSQSVLSRNLKHFEDNKITYLSQPHWQFCKNSTSSKSIVKSNPKDMVTSTLSAITFLNEWQFVTGSSVSLTGIRCWDVRFLPQSNISNVEPLFTYKMPISKRDYGIAYIAVDPKRSNFYAACTNNEIYMFSSDGAYEDPMYAMVNNLGEGINYSSRLSISPITDHLLVGTSMDCVKVFDLSSLFHRKRNNLKEFDYTLPYSKYLLQGHGSDTNIVNYSIDGKYILTGSCSNIRIWEYGWDKDFIKTGEELNQVEKPTRINETNSINKQPHLNFTFPIPKLGLQNNQPTSNVTPKRKEANLKRKLLEKNENDVVKKGKFFPLFNPYIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFE6</accession>
    <name>A0A0N5CFE6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFE6"/>
    <dbReference type="WBParaSite" id="SPAL_0001658200.1">
        <property type="protein sequence ID" value="SPAL_0001658200.1"/>
        <property type="gene ID" value="SPAL_0001658200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001658200.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21353" checksum="EDD1C3204DB730DE" modified="2015-12-09" version="1">MTSRKNNEIVEMYTIEEDDNISGKNFDTLTVTSTEINFTPRVGKFGAPRCVCLSSVVALVAFCFGMILLTTGTCILVFWDQEPIIHPLGYTLIGIGMILFVMGSCMWMSEFICGNCFGKLYTKMKEAPMKNAIKRREKIIASRMSQNSQARMINSRSGSRMSINSISSSTSTISHDPKGTSTAVVKKTIESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFY9</accession>
    <name>A0A0N5CFY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFY9"/>
    <dbReference type="STRING" id="174720.A0A0N5CFY9"/>
    <dbReference type="WBParaSite" id="SPAL_0001676900.1">
        <property type="protein sequence ID" value="SPAL_0001676900.1"/>
        <property type="gene ID" value="SPAL_0001676900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001676900.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11944" checksum="778B8ECE858F24AE" modified="2015-12-09" version="1">MVSWLPKSWNFQSVDDLWQFCPNRQNFVGDFFFQSGRKLQIAPQTLGNVFVEVLEKRVTNRKDCNEPPKRIIVLLDGLTDAQFRDAIHGEIGGLRAACERFQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH61</accession>
    <name>A0A0N5CH61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH61"/>
    <dbReference type="STRING" id="174720.A0A0N5CH61"/>
    <dbReference type="WBParaSite" id="SPAL_0001718300.1">
        <property type="protein sequence ID" value="SPAL_0001718300.1"/>
        <property type="gene ID" value="SPAL_0001718300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001718300.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56672" checksum="96FDA430F1933778" modified="2015-12-09" version="1">MATQTNRRCFPEWINPFNILVFVLWQSQSFMSVQMIFPIFSNYVSKWRCDGVGDFSKNCTIYNSGCKIEYENNHFNSAAIAFGWICSDISYLMAFSSQLQFFALLLGTIFFGILSDAFGRRKIAVVNVSLGCLTILISSLIKNPYFFVGSRFILGFAVGGVSTSGITYCMEVLPSDKRLLVKLLFNWGLSRLLITTICYFFNDYNSALFVHGLLLIPAVMLLIFYFPESPTWCHYKNEEEKMIESEKRIAKYSHLKYIPVQHEKISKKESFIELLKQKETFKRLSVLWFMWFVVSLCSYGIDLSSNDISGDLFINQYFFAFTIFISKILIPSIDNKFKWFTRRLFHQGSQAIVVMCFGILVFLVSIKYHGLAILILNVTGIVFIEFGWDACYICTIESMPTNVRTSAVGSCSLVARIGAIISPILPYFNSYWSPMTYFIVAVLGSMSLFISYLFLKETKNIALDRVHLTEKNDHNENASIELLNREMKNVNESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIF3</accession>
    <name>A0A0N5CIF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIF3"/>
    <dbReference type="WBParaSite" id="SPAL_0001760900.1">
        <property type="protein sequence ID" value="SPAL_0001760900.1"/>
        <property type="gene ID" value="SPAL_0001760900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001760900.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25843" checksum="7BD445AE6258014C" modified="2015-12-09" version="1">MVMSLEYVFACIVHIIFYLYIFIHHNSNKKVNLRTCSKLESIHYGSIHVLNVTLLYVTVIRFYKIACRKNPNIIVMGLIVLFTLGPLVYLYIGKFFEISVYFIQKEGCGYDMYSNLPYYNFISYAIIFIDLLSSLASLVVSYLTYRVVVRKTPIASIGKIKENKSLFKSFAIQSLFPFCYQVPAVIYYLLYLKIRLFIALFSTIFLIFFQKGKELKQLKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIF9</accession>
    <name>A0A0N5CIF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIF9"/>
    <dbReference type="WBParaSite" id="SPAL_0001761500.1">
        <property type="protein sequence ID" value="SPAL_0001761500.1"/>
        <property type="gene ID" value="SPAL_0001761500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001761500.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42775" checksum="B3CCAA5DCB8F0BE5" modified="2015-12-09" version="1">MDFIYLYPSIVFLFTILYTFLSTCTTKKKDGKRNMYKGISRTPSVFAKDRKNKAKPEIEVLSLREEKMNSSSISKRTKEKDRKSNVVSSKEKNDNNLERKSNNSKNQPFQPKNMSIKNPTVHTFKNNNYDLQMTQKQPVGIAVDPNQMIQAKEAVEIPKNVIDPVKTVGDLEDESPNDKNKQIEDPIKTIMNEPDLQKCTQVDDEINTVVPGKLCETQPYDLPNKDELKNGVPPPKQIGSQKNNDGKSEVGSLINDSKAMNDQYETLNNIEFAIPLPIPPPIPPQDNKSIKDVNVEVKMTNDKTDAEKNDDKKKAVEKKDVVINKKEERISNGMLKSDENKKELNKTQEKKSVTPKVENKDKKLIRDEKNKGSPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIL2</accession>
    <name>A0A0N5CIL2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIL2"/>
    <dbReference type="WBParaSite" id="SPAL_0001766700.1">
        <property type="protein sequence ID" value="SPAL_0001766700.1"/>
        <property type="gene ID" value="SPAL_0001766700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001766700.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10439" checksum="DDAAFBDAFA6C764C" modified="2015-12-09" version="1">MDLTQINCMGINGYCCRLPKLTAVCDPFSHSDYGYYRKGRNLFELASNPGQGKEEKKEKKALISPEQKKILNKNILNHRFRDHLRQLVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIR4</accession>
    <name>A0A0N5CIR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF223 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIR4"/>
    <dbReference type="WBParaSite" id="SPAL_0001771900.1">
        <property type="protein sequence ID" value="SPAL_0001771900.1"/>
        <property type="gene ID" value="SPAL_0001771900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001771900.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19662" checksum="A3E414D106EE9F64" modified="2015-12-09" version="1">MATLVQIYFTNSKSRELFIQKEVKVSPVKLVVIHLRKAVIKATKSINYFSCFKEIATLVQIYFTNSKSRELFIPKEVKVSLVKVYFKLKDDQPSLYEEGLIVAKLDIGTNLIETEAVRYYVGIDFCHFEFTSTLRMKRSISTIMEVEGDVEEEREDDIQERKQSEVVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIZ7</accession>
    <name>A0A0N5CIZ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LIM interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIZ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001780400.1">
        <property type="protein sequence ID" value="SPAL_0001780400.1"/>
        <property type="gene ID" value="SPAL_0001780400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="3">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LIM interaction" evidence="3">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001780400.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23201" checksum="070A6C1E90FD4F72" modified="2015-12-09" version="1">LFSFALVQKKTRKRNRKNVLAEIGETASTGSPESLNKKKCSIDDSSAENSPINNNLIITATSSDSKKKQAYSNGFEVSQEPKTMEENFNSENERKMFRIEHSPANINESSQQQQQITPMKTINLIQLIVLSDSKKKQAYSNGFEVSQEPKTMEENFNSENERKMFRIEHSPANINESSQQQQQVSNKPLMQQNFYSMINQIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1X7</accession>
    <name>A0A0N5B1X7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1X7"/>
    <dbReference type="WBParaSite" id="SPAL_0000007800.1">
        <property type="protein sequence ID" value="SPAL_0000007800.1"/>
        <property type="gene ID" value="SPAL_0000007800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893620" evidence="2">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000007800.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18380" checksum="032154A109F7627E" modified="2015-12-09" version="1">MHFIKYLTIFVLLAVQYSFQDSSSSSESSLSLSEEALPEVGTQLEKTKKSFLKNLKDGFKKEKEKAKTFLDKNSTLKKIKEKMQETNNKLKQSLKKDKEKLTKLTKNFGGKISNLFGKNKSDKTSLNENDTRVKRSLVGKVAKGAKNVIAGGAKRAKALLSKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2Y7</accession>
    <name>A0A0N5B2Y7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2Y7"/>
    <dbReference type="STRING" id="174720.A0A0N5B2Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0000043800.1">
        <property type="protein sequence ID" value="SPAL_0000043800.1"/>
        <property type="gene ID" value="SPAL_0000043800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000043800.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14263" checksum="508D42034507E86F" modified="2015-12-09" version="1">KDVRNLNKCFKDVLVVEIEFPMDRSSVNSILNIYECIESLNDKNYKYLFLLQNDDVLLQTDRRLVQIMMLYNGSLDIDFGSSFTSRPVNVIKNVSFKHKDLNIFKKVNWFLLVIFRLFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B304</accession>
    <name>A0A0N5B304_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B304"/>
    <dbReference type="STRING" id="174720.A0A0N5B304"/>
    <dbReference type="WBParaSite" id="SPAL_0000045500.1">
        <property type="protein sequence ID" value="SPAL_0000045500.1"/>
        <property type="gene ID" value="SPAL_0000045500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893659" evidence="3">
        <location>
            <begin position="20"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000045500.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="76286" checksum="53B6F34A59F9A228" modified="2015-12-09" version="1">MRLLSIIVCIVILLNLVTSDRGFDIVKSSSSHLYDDSMELTSSNEKRSLETQFDSSKNTKTTDDDFSLGEEKETSPKESEMSLEASEEDPFNKATQQPNEREKNNDVLTTNPLDVTLPSSTTKINSLDMIEKITTADMDLFNDETTIKMVNEGLAFMMKTIPTNINNNQEDLITTSSPKEIMNDRNLESDDKSDMFLDISNEDGKEKISSKTTRDDVQFDIGDEDSNEDQNSKIVVKNDDQAMNSSSVVDIKAAEDITIPFNAADTLLTTEDPIEAKNTKIHNILLNEEINGTESESNSMEVKQSTIFVGPSITTTHLPILNKEEDNSEVFVIDDDKGIFSHVPTTISPHIEEKSSETIAHLSTSLTVSSAEETSTKFPDSSEFTELTSTVIIPKILSTTLEPTEESIDDKVLTTLIQEVDFSKTTEPSIIIDVSSSKDDITTSNKIDAEIMTTINELLTTQFPEGENMTFDEKVIQSKENVEGDIKKANNKSDEGDDGIILNHEGVDLSTTTTTNSTSTTTTSSTTTTTTTPPTTISTTVSLNETSPTTITPENIAIEIMKNLQSETANKTNEDNLTFAGFLFSTPISDYIIPIIIISSIIFIIFIILLIYITCKKRKENGMLRFTNSQTSSTLSKIEEGVNMDHVNDYRYHDNSRVSVSSIPKDKDVNLVGFGPVDAVSKNEIEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B323</accession>
    <name>A0A0N5B323_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B323"/>
    <dbReference type="WBParaSite" id="SPAL_0000047400.1">
        <property type="protein sequence ID" value="SPAL_0000047400.1"/>
        <property type="gene ID" value="SPAL_0000047400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000047400.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="16143" checksum="D44D6EAFF263C928" modified="2015-12-09" version="1">XVTLKIDFRPIYLYEFKLRQAVAKSSRKISKAFGQRSTNKRTIQRWFQKFRNRDMCLQRKEGFRGINVLKNEKIKRMVEHNLRITVRELTGELNISIGTVSNHLKLINIKKKLDSYIPHEYTHREIYTKNHPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B497</accession>
    <name>A0A0N5B497_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="174720.A0A0N5B497"/>
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        <property type="gene ID" value="SPAL_0000089900"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="3">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="4">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000089900.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41666" checksum="390F5948EC1A4CED" modified="2015-12-09" version="1">XGHIVSQKGIEIDGNKLDTIDKLIIPDTRKGLRSFLGATNYFRKFILGHAKVAAPLTKLLSEKIEYKWTDEQSKAFLELKKRLKTAPVLAPPDLSRNFIIHTDASEFAIGAVLLQKNKEDQYPRIIACASRTPEYYIEGKVTDVFTDQRAVLAIKSPKENQSKLRRYQLALAAYNLNIYYKEGKANVIADLFSRNPEPKESLVLMAHTIKQVTKDDDFKEMRTSLFMEGWHTSRKDEDFLQNEMKNKFRRLGNLVIVKIRGEEKFFVPDGERVKLVKHIHEHPKIGGHFGAHRIKEVITKYFWWENMEVKIHCEKCQKVKFHPETTTEWRGTWDIPDGPWQRLNMDIRGPLPITARRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4L5</accession>
    <name>A0A0N5B4L5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fgf-3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4L5"/>
    <dbReference type="WBParaSite" id="SPAL_0000101600.1">
        <property type="protein sequence ID" value="SPAL_0000101600.1"/>
        <property type="gene ID" value="SPAL_0000101600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893734" evidence="3">
        <location>
            <begin position="25"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000101600.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41049" checksum="2691FF3A0122E3BC" modified="2015-12-09" version="1">MRLFHTLKFSIVFQILTLLGSISGDYLPLIGSLQSIKKIPDKLSYYQLIKNDESNTEFGFKCLPEPGRNLQTILPPSEFVVKYTKPSQEIVNVLNARFSSDSLYGFGMYRCVHSSGIGTNEIYYLPVSSYKINFNKVNVTLENKPNCKMNYYFAQLVKVSVNVNGIEEYSNKSNKHSLTILTISNQNFDIVNQETVYFKNYNYSADITVTCTYKLKDFNIVDDKFETNQIFTYKKSNVTSGKEIINKTSKQTFTKVEKTSPIPIIIAFVVIVIALVITAIVIAVIVRVKRRRRRRRQLEESALSAAQSGSSSQYSSSSTAGSSSYTSKSKQKKGSKTGSKTGSKTGSMTESRSGSKSGSKSGADPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5S4</accession>
    <name>A0A0N5B5S4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5S4"/>
    <dbReference type="STRING" id="174720.A0A0N5B5S4"/>
    <dbReference type="WBParaSite" id="SPAL_0000141900.1">
        <property type="protein sequence ID" value="SPAL_0000141900.1"/>
        <property type="gene ID" value="SPAL_0000141900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000141900.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29566" checksum="03127D9A7E7207CA" modified="2015-12-09" version="1">MDTEVVQHSGNGVAPVKKEFIVNFNDNNLPSYVKIRLEEEKEDKAAVVGKEEENGEPVRKKPRGMNKGRRKEMDKTRIEISTNQPRLCPSTIFALRNKSYGKEESTDKKCRFGDKCKYYHSIEEYSKVRQPDIGEKCYNFEVRGECPYNIACRYHKDHTIENFEQKVDEKKKEEYNNIPVCAMFRNPDIKIMLNKNRYNFKESDELVKGFNEENVVKIGAMEREKASLKVREMSGKPYLAPLTTVGNLPFRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Q3</accession>
    <name>A0A0N5B6Q3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Q3"/>
    <dbReference type="WBParaSite" id="SPAL_0000174000.1">
        <property type="protein sequence ID" value="SPAL_0000174000.1"/>
        <property type="gene ID" value="SPAL_0000174000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893969" evidence="2">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000174000.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21229" checksum="94696EE0DFD4EA72" modified="2015-12-09" version="1">MKLSYINFSIFILLSFTILGYGLSNSSEADNEKIVLEPKKVFNYTQKIDKCLNVIKEDKGEDYTLNDLEINTEIYGVDKIDVTLFDFNLRFNGSEEVEQICTQFIGFGINMTSECTIIDCPWGDYDSDEDESMVVELEGDESEEGESEGQESEEGELEGQESEQKQEEGELEDDEQEEKELEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6S6</accession>
    <name>A0A0N5B6S6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5B6S6"/>
    <dbReference type="WBParaSite" id="SPAL_0000176200.1">
        <property type="protein sequence ID" value="SPAL_0000176200.1"/>
        <property type="gene ID" value="SPAL_0000176200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="664"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000176200.1"/>
        </source>
    </evidence>
    <sequence length="1607" mass="183662" checksum="F211CB7B2B03CC6B" modified="2015-12-09" version="1">MRRRTRSTNPITTTEENLTVSQIFENIQQSANSEVLLNMSNTTDPPILNGGQINPETPTNGNLTTQNHPPTQPNGIDMGQLQNVINEMIRNAINNYLPAVLPQVNQPTCVTQPPPQVIQPPCVTNVIPTNQIENTVTENVNDEMPIVNNREDLDMLNVHRNRMIYSNDRHSSVMPEKFNVKDNFAKWEIKFNSYCRMNRISEIDKLDTLILLLDNKVLQEVYDDPSISSSYLRLAQYLRRNFNGGLTIQAASDELDLLIARRVTRADDLDNVARKIDNYIDIMFPSDNRERKNEVKIKYLSKVLPSAIQGNYFCKPMNTLDEGLAAAKTLWFQELRAEKDKARGHSILKSYNHRSDNRNVKPYQHQKSHQNNLYCSYCKMNNHSTATCRNSKNKLKAQSNNIEVNDPQSNNIEIVPKDVKTDLINKDEMKNDVINNEVCDNYEVQKVETIDESPPLPQNHSFRAVVKLNGLNVIALIDTGSNCVIINNKLKDKLGLTTCEERNISTFQSDNTALKISTPITIQIQKEKFIINENVYAAKDDFKNNSYDAIIGTNVLKRMMAVIDLQTGKIIVNEKPKDLVKDDNNISNVILSDQDANINIDKFVTDLKLKYPLAYARHSFDIGPGRIMVNEIEVYNNKEMIKAPYYSVPIHEKESVSNLLQTWIDNGLLERSESNCLHPIMLLTKDGKRDDLESCRFIADLRQVNSITKSVNYNTPKIQELLQSLQSFSFITKIDLKSAFFQLSLPPKSRQLYGIRTPIGNLQFKRLPQGGKVSSAIFQRTMEETFYKLRKNCLIYCDDILLFSNGTIQDHEQLINQFMKIANEKELKVSLEKSVFFAREAKFLGYHITSSGTRPDSTNVDNILKRELPKRKKQLISFLQALNYFRHVIPNFSRTASCLYELSAGRDCAITMNEQQLECYHALRQQLMNAPLMYHPIHGIPFTLTTDASNHTIGAILSQTQNGIEVPLAFYSCRLTKTKRARSPTFLELYAIAKSLQHFKYLLSSAEIIIRSDHKPLLHLSTSNSDKKYMELLETINQFNVKWSYIPGKSNFVADWLSRLCNENSPSPSTNTVLDTSNVASSNEIVKRQRGRPRKCQRLNSSVENLKNVKGNTIQPVDIKRRRGRPVKNISKLSNSAITITRKRGRPRKCSHKSDNITDLTNNFDKNVDTDEKVLPLSSDVNSKPIDDTTIQSSDDDLTFVDAATEIMSMIDLTKLDLVKLQSEDVKCQNALSSGKLDNHVCYKDKNGLIKVKIGKEETTDLIVIPESAADTIFKLSHDFNGHFSFLKTKENINKSCYISGLAKKLENYLKNCHHCKIRNTVMSQQGPTKTILPANVMEELSMDFLGPLKVLGSKKQKFILNVIDTGSRFVFPIPTQTQQHEEIMYHLMNDIFLKFGFPRKIRCDNAQNFKANSLKELLGRLNIQLEYSTPQYSKSNSICERYLRTLQAGVNKLISMTGRDWDCYIPYLAYAYNTNIIRSFNMSPFQLMFARSPTTALDLFLRGFDITLHDRELDIYEMMERAQVTRDIANERHLQERLYVNNGNKNKEFKTYAKNDLIYVKNKMRKGKFDNVYDGPYPVVTDLGSKIKYKAASGRILTSSKTNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6X9</accession>
    <name>A0A0N5B6X9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6X9"/>
    <dbReference type="WBParaSite" id="SPAL_0000181500.1">
        <property type="protein sequence ID" value="SPAL_0000181500.1"/>
        <property type="gene ID" value="SPAL_0000181500"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000181600.1">
        <property type="protein sequence ID" value="SPAL_0000181600.1"/>
        <property type="gene ID" value="SPAL_0000181600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000181500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000181600.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="33226" checksum="335983D140DB424C" modified="2015-12-09" version="1">MVDIILATNMIQFIYKIPAIFLMILSVYVILKEIRKKNVLFNKQFYILIVCKLFNDICYMIFYYTLYKIPQYGFFKTFFEKNDWIAVLCYVLAALHITFMFLITLLISINRYVAVKYPTKYEQYFSKSNRIKIIIFFIILSTFIGLGTIPFKAVYRMFNFADLFIPYFRSKKVIYYQIFYTIVLYGTISIATCIFNIKAILKLKKLKKISKNYKKEARYIIYSVFVFITLATIEVFYVLSHISAQYEISSIRYIIHFCIVIGFDLISVGDYYFLIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8U7</accession>
    <name>A0A0N5B8U7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8U7"/>
    <dbReference type="WBParaSite" id="SPAL_0000247000.1">
        <property type="protein sequence ID" value="SPAL_0000247000.1"/>
        <property type="gene ID" value="SPAL_0000247000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000247000.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="73365" checksum="88B1557680C76B9B" modified="2015-12-09" version="1">MTKFIYIHLIFVIHICYLFGLITSDDSFRAEDYRLEYYRNSGDTNFNWKHFNGIKLNHRKFKIGSFNLNKSVIVYKIHLTRDFLIGRSYNSELRISIFNVHDLSIKKDITPNLLPREYNSKNSRFERKEGFLTCNIFKCHIGILYRCLDVVNNCSDSYEAANFFYIAFEKSSEYDNLVMKLITKNNNNTYMFSVVVCPGKTWLPPSSNFEYIPTGENSITKLVSNDSSREYAVKFVYCHETGVKTFTKCGYLKQMFMPQIDVGYQCDVYNEMETSRIHNNYVTESFMIPLSSGELTCNGVDISNSSSFVIGVLPPGNNYNNVSDFKVNVVNNRTNLYSGHRLHSLNVSEVYEHYEEAELYLGYAIHYEAKCKIPSLNATLRLQIDGTVQEFDNKKEKNIGGMNIYKFDRRKIKDAPVGCHAVLDEIKHSALNDYYKLLYSTSLLMFDEAAQKYIKVDDIQKLVSNGKYKCILNMKSNTSEIDKPNYIKETEFTIDLTGEDLKKTADYKKFNKSHIWIIIGVLIFVVLLLIIGFIVFKKLRLKGRKSKKNSSLNLSVSSSLQVSELKPKSPSALSKSISKSTSSSQSAAKFAGVPSAVPNAASNNKIDAGKTLTNMTKATVSKSLYSNSKVSNFGKTEVVNSVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8Y4</accession>
    <name>A0A0N5B8Y4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8Y4"/>
    <dbReference type="WBParaSite" id="SPAL_0000250600.1">
        <property type="protein sequence ID" value="SPAL_0000250600.1"/>
        <property type="gene ID" value="SPAL_0000250600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894165" evidence="3">
        <location>
            <begin position="17"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000250600.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="80358" checksum="4417292ECD3B86D3" modified="2015-12-09" version="1">MVILLLCLSILINSCANLEFHGNNHLYDPKFELEKGTAENGGKIKFETIATKNINKSEIFNHITLRNIAYHQITFKKMNSGDKGIQSKNSDAKVTAIDSTLAHGNSLKLKELNIFGCDLIECIVGFVFYSSVGSGKAIIDNKVVDFKGVLYHKFISNDGFISFGDIYVYDNHFPLILCPYKNWINTLTLSEFKPKEGTGILFDKFYNRHILQPMFPRNPYATRFICGEIYYSSDRSSVNIGYRIKFLLNTDHKALETTNIDLLKDKLVCHKQQKEDDYYHFVHGTYNGKETQMKYLNLKSPNGVNIYNDTKIYLYNKADQQIKKLNEQGVKMGNNFISIEPVCALSVKPLSASIKLYTKDGKEVAFSSSGNNTAKKVLYVDEKIVKDVKDYKCRVVVDGTNKEYIKNFYTSTFDAQLISPQSNGDEKIIKNLTLKEDLKGFGKYSCKLIPKDGVNDRKREQNIKGLTFEMVPSGKLTTLKEELWNSTTDAMIHCDIFAYKDSKLSDMSVTLSNTSKYTNSIKADKKMFAEETTYIKFKILDYINENKTFEKINYNCIYKTADETVYSVQKKANIADPELMQSDYDDTSSDDSKGTTILIILGIILIILFVATLIASIFIMKKLRKNRNIRKQLGLGRSSSSSASSSSSFSTSKSSMSGLSGVKSNISGINSNMSGVSGSVSGLSKNTSSKMNSKVSKVSKPTPTSNVQRINFVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Q7</accession>
    <name>A0A0N5B9Q7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Q7"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Q7"/>
    <dbReference type="WBParaSite" id="SPAL_0000277300.1">
        <property type="protein sequence ID" value="SPAL_0000277300.1"/>
        <property type="gene ID" value="SPAL_0000277300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4010:FF:000002">
        <property type="entry name" value="Held out wings, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000028">
        <property type="entry name" value="protein quaking isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000277300.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="54479" checksum="F46F96E2746B1FB9" modified="2015-12-09" version="1">MNTITENVINDSASNNNKLGGPTEPDQSSSDGIILSTMDDSKIAPTIDTHNNNNTSSIPSVTSSTGISNNNHTITHQSIQQNYTVEYLAELVKDRKQLLAFPGIFIHIERLLDEEINRVRFALFQFEFTKEQLILPSPIGEVITVTEKVFVPVKAYPEYNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDMNRGKPNWEHLSEDLHVLIQCEDTKNRCDVKIQRAIEEVRKLLVPAPEGEDELKKKQLMELAIINGTYRTGSNGLPVNPLTNQPLATGALTNTGSKSLAGSSVLASTLGSIVPQIRSPSLVGTPIVLQQNATPQHRSTPNSAAAAAIAAQAQIQAAQQAAAINLINQNNSVNGSGGVLGGGQLLAAAGQQVSAEYQQLLLNQLGYDALNGAAVANAAAIHHQQQQQYAAMLMAQSGQGLLGEYQQYDLTGALLPSSQRRSNTLNNIPSTTTTAVGSTPSSSVRAETHPYYHPSHHHHHGTGTAGKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA55</accession>
    <name>A0A0N5BA55_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BBP1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA55"/>
    <dbReference type="STRING" id="174720.A0A0N5BA55"/>
    <dbReference type="WBParaSite" id="SPAL_0000292400.1">
        <property type="protein sequence ID" value="SPAL_0000292400.1"/>
        <property type="gene ID" value="SPAL_0000292400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000292400.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31719" checksum="C823AA6958FCAD70" modified="2015-12-09" version="1">MFKGLKSKLEDEAKKLSTAMSQYGENVAQQLRTGENTGSLLNFNKTNNESDNNKSKKTRDNKKNDDNPAIMQEFDETSLFSLSPVDDTLRTRRLSNCSNISVNSNTDIFSFENLIPQKSTIQTELESNADESVIGSSTFTSASKEQISSLLNKLNNRSAKYKMKYKNLVATYNELVTENAKCQSVLEQTQDATVKKIKQLKNEKLELEEKLRNIQSGAIPSDTAKIKKLEELLEKCKENIFTNKAKIKNLNIENMELKKKLNDSKGLVDGDKVLLVLYVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAF2</accession>
    <name>A0A0N5BAF2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAF2"/>
    <dbReference type="WBParaSite" id="SPAL_0000302200.1">
        <property type="protein sequence ID" value="SPAL_0000302200.1"/>
        <property type="gene ID" value="SPAL_0000302200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000302200.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="62619" checksum="6255E339126C0BAB" modified="2015-12-09" version="1">MSSRSHYGRAKDRLPLITLTDMPVSVISLISSNLHPVERIYLESMCKKLRNASKFWKDIKTILLKSYLHELDEYSVKIERKKKKNSVINTYIKEKNFVTVYHAQLTTYNGTTYTMYSDPLRILNMKTIGMIFKRCINLNKLIIVGTCLNDSIIPALVYFENTLKVIKFWNCEEYFDKKRKPCELIKTLFSFPYLSSIMILSTIRPKYATFPDHNIVKYKLHPELVSCIVAPVEEIQLTNLAIPLKSFKILTDRLCTSLERLSIGCTYGDAKKVSSYAKALTEFENLKDLDLPPFIFSINEDYLINLKVYNALCITKVQTFGFRHYNTSALFKFIRNDLPPDIKVVRIFHNPGRIPNFKQLGYGPTEKKISVTSKISKNSNTSSSNNSIVGVYSRSIFKALRIKKKIHLDDFPNHSPRDSFLYNIDKNGHPNGQFGIGNGIPRRELSIFAVEESCRSVEKLIHKKYNCLDVYYTSDVKKYQEVVGKMASPMPLQHPFKLDIDGSLTNSKIVPSNTVTRKNSEKNDIHQKPVTKFFNLLRFKQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAZ5</accession>
    <name>A0A0N5BAZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAZ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BAZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000320900.1">
        <property type="protein sequence ID" value="SPAL_0000320900.1"/>
        <property type="gene ID" value="SPAL_0000320900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="79"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000320900.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62258" checksum="D08E3894C64251E7" modified="2015-12-09" version="1">MVLLFPLIDSEKIYKLPHIVISFLQLLHIFYCTIVNFIFNVYLFLSKKEKLPKIKNDLLLIPATKCAQMIRDKEITSYELVKAYIDRQKEVNPFINAVVLERYEDALKDAKSIDEYLEKIKPYTKEYYKIVDEKPLLGVPFTLKNSIKCEEFPPIAGIVCRNHNETKADIMCKGVERLKNAGGILLASTNVPELCMWIETNNKVWGRTNNPYDTRRSPGGSSGGEGAIISAGGSLFGVGSDIAGSIRIPACHCGIFGYKNTPKSIDVRGHLPEPDEKIMNMVAQAPMARYACDLKLISKIYMSEEERVSLRMDEEVDINSLNFYYIEDFSFMEAQPMTKDCLQGVHSVVKMLEDFNKVPVNLYFDEFKYSNVLWQATLQYYTDDQVTGASGYMNNFSKTKVPFLQEALKNMFCLQSNHDLGVMLWLYEFENLRFLNPQLKKKYLDMRDKLMKKINDILGDNGILIVPAYPTVAPPHNHQLFLRMDKSYTEIFNVLGLPVITCPIFLNSSGIPVCVQIAAGKNQDRLLFSFAEVIEKKFGGWREPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBX6</accession>
    <name>A0A0N5BBX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cir_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBX6"/>
    <dbReference type="STRING" id="174720.A0A0N5BBX6"/>
    <dbReference type="WBParaSite" id="SPAL_0000352600.1">
        <property type="protein sequence ID" value="SPAL_0000352600.1"/>
        <property type="gene ID" value="SPAL_0000352600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000352600.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="31281" checksum="557024EA976971F3" modified="2015-12-09" version="1">MNILPKKNWHVLRRENIKRVKDDEKKAEEEERRRLERVHRAENEKKLGELRKHRDTDEPGPSSKSLLRHINLFEEEEVEGSNERNEEYEKERKQKIDKFESQLGIKKMFAEGTNELNKTQSWYEKKPERHYDDFNDTLIDGKKVNWKDMLKERCSKDVEEFKEALMEEIKRQKKKEKEDKKRRRKDKKSSKRDDKKEKLKKLREDRIKREKEEKRRVNVLFGIKEEKEEKNEVEKCDKKPIYNSMYHPELARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCB3</accession>
    <name>A0A0N5BCB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCB3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000366200.1">
        <property type="protein sequence ID" value="SPAL_0000366200.1"/>
        <property type="gene ID" value="SPAL_0000366200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="223"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000366200.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44830" checksum="AA443ED42D165EC5" modified="2015-12-09" version="1">MESMNSADSDVGSNTKIDLKRGRFICAIENFSIDHVDFKPCGQFVSYGEGYFCDVNKLCKECDERKHSMQSVQTFNFKLETDFEENHYFSLHIEPACCYDESEGCISVKLKFHELGDFEVMALCKFSILNAEGKEEYKSVICVKRFDENNDSYCHHVNINIIDLLDRKSMLLPNGRLTLCFEMFYLINFDLNSFYVSKWTHIDKQLNMFLNDMTRMLDSSKFYDCKIKVGNHEMKVHKCILTARSEVFRSTLENKDTEHELDIIEINDFNWVVVKKMVDYLYTGEIPTIKYIAFEMFEIAEKYKVEGLKLIATGSLLGSLDVSNVCKYLEKSEIHSIEILKEFCIAYIYFNVKEVVKSKEWRKIVNFYPSLLERIFNLTADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCP5</accession>
    <name>A0A0N5BCP5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCP5"/>
    <dbReference type="STRING" id="174720.A0A0N5BCP5"/>
    <dbReference type="WBParaSite" id="SPAL_0000379000.1">
        <property type="protein sequence ID" value="SPAL_0000379000.1"/>
        <property type="gene ID" value="SPAL_0000379000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF120">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00059808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000379000.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13600" checksum="7327EDD6ED946CDD" modified="2015-12-09" version="1">MTTLEERFKAAVEIVQKLPSSGPLTTSNDQKLAFYSLYKQATIGNVNTDRPGFFSIVERKKWDAWKEKEGLTKEEAMEQYIEVLLETFDNIEGINVGEWLSGPDLDPSIKKNLAILGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDE4</accession>
    <name>A0A0N5BDE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BDE4"/>
    <dbReference type="WBParaSite" id="SPAL_0000403000.1">
        <property type="protein sequence ID" value="SPAL_0000403000.1"/>
        <property type="gene ID" value="SPAL_0000403000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="5">
        <location>
            <begin position="57"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="208"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1637"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2009"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1653"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1741"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1795"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1808"/>
            <end position="1827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000403000.1"/>
        </source>
    </evidence>
    <sequence length="2051" mass="237071" checksum="12E65CBB3F064977" modified="2015-12-09" version="1">MNEASSGSLQNGKENDNDNKEYKNLKKHETLYENFCIVGQIDCNSDVEVVSKNETSKEPIIDIELVFPRLKESVKDDYEIISSTPGGTVADLLHSSIKHTECFITIRRGFSKMPIVDIGILDESNGEQLMADSVAITQTRYGNSANISGNKNKQVYLTFRRLKTVSEISTNEVVTDICVINASNNEKCPASFYKIDKVFNKSLTASNMYICYKKSRRARRSISYSPKILDSFSNDSCKVISPDVANFCMPNGVEVVCWPITKPYPEDQVSSFVLTDDKAKKTYATCLTFYELHNHKLNDEQKQKLNIDEVSNISKNDNSSNNKGEGSEEFERKIDKKEYNEMRKRLIDNGITLYTPIEAGDNEITKLSLDSTNDDLIILKNKTIVFISKFPFTEGFKTILEMLRRYNLINSSSKIPVERVLSYLMYEVVYPAPKLPQFRLHLFNEKILFNLQDIPEMPLSGARLFDCLNQLGVENMITIFLCILQERTLIFHSMRHNTLSPICETFVSLIFPLFWQCPYVPLCISEASIICESPVPVIAGIDSKYFDVEGDQSTDAIFFGIDTQSSSLSNDEVKRLMNSIPSTPLKILRSDLESLHRYDSFSQMRAYSSLISRDTHFETFKTVEKANLKIRWYFLKFMSALLKGYDECILPLKKAPYLDNLKDIQNVFDFEKFIRSKDRQTLPFFKTFVNTQMFRHFIQERIFSSEKNEFYFFFDDICRKCEVSPNVNYNIEDAHLFIKTIEADIQCSTTVLKKVKKFTQFPNQLNCELYDLDFVNTAVGLKDSCEMLTKDPQLRNLNVLRSVYEFKCEKEKIHSHLTEATFSWPRIIFFEINAIWFSLLPSFLQKIDNKILGLNLGINYLFNLLDTKAIILDQQPFRVLIHLCGFYGKPYWSYRVFQLMQSYGIMADGITLPIYHKAITAKGWPSENGIKAYRKFKGIGWFIIGANHMIKTYIKVSPSNDMGNTGKDVNKMFKTLNISEDNENEIKNEEICHESFNPHKYKKTLYNYMENCAECKDLPMSFDLLEPNKNFMTWKGDEESVTFNEGQKFPELNNYINNMKSQGLLLKFRKEVDEVKKEDEINENDIYIDCLHKEHFDTDIPITADVSLLTDSKGYFKVESNVEKEKTKLNVSSGSLCTSNEMDPLNDIDDRLTINTEESLKNDDILSSSISVRVEPLGVDELSDKSSKTDSESNLEESRRRFLIEHLSEPFSEKKGEQNLIDSTKLTPSKSWFKTLSKSPLVSKILSPSLVNKQVDTSNLKHSLSTQSLSTIFFKPVQQVAKNLFGEMKTKWKTSNSNDIPSNDELPLGIEQETDHFTQKIYRISNGFVYGFRGIERFSTLMNQYADSYPFLRKCNRQLKRIELCIASKCTRPECGNINYDEEIWTKFMDSPEPSIYSCYHCGHHFVPILTVKVFSNTIMKKSSYYQQNHLREKVEYGDNEDYYTSFPVRFLNPIYLRMILETQILNCNNYSTGPGFFYDHQMLYYNLLYYFKRINMLSHVNLWCGTNVQVICTYDVPELHEDKNQPLYLVSKQIISKPILTETLLKRPPFRFLFDIINETISETSYLSDKYTKDTLDIEKLNDKASKVSFLDDLIKIVNDDGSLDNLKASKIVAGKDAELTNLFLQKFAKAAKDFKKTRKKKNKEKEDEETKESSKKSSSSHSEKKSKKEKDSNDVDKSKDEKKTKKKEKQKDKEKEKSKDKEKSKEKEKIKEKEKIKEKGKTKEKGKSKNGESSEIIDNGEKEINHDTSKKTSKKSSEKSHKKKEKNIPTVDVNSIGEEEPHSSNKSTTTRQKIIDENGQDDKQLVVQSNKDNHVNSNYEPQRITSPLIRPGTAVARPPPPKLKKNQIIYEEENAKKEDGPSNSVAVITEEESKTENIDEDVFVTEEIPIEKFNNTSINVNKINEDQHGILVNKIVENTKKIESDTFGTTSKEYIYDNSEYIQLKQETDELRKTIQHLTQIIYPLAQIFDFIQEDFDEMLRELDIWWKEISSNLNELRQQQNILSSTEANEKLLRNLNSQIKDKKEEIFNLKASLINTNIFLSNYITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEC5</accession>
    <name>A0A0N5BEC5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein lifeguard 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEC5"/>
    <dbReference type="STRING" id="174720.A0A0N5BEC5"/>
    <dbReference type="WBParaSite" id="SPAL_0000434800.1">
        <property type="protein sequence ID" value="SPAL_0000434800.1"/>
        <property type="gene ID" value="SPAL_0000434800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000434800.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32543" checksum="77BB3699187FD0E5" modified="2015-12-09" version="1">MAYSYNGQQQPYPNTGYNPQGQNPYQQMNHPSQPGWNQNAFFPQPPPRMDTGGYSTESGHGDKRFDFTEASIRAAFVKKVFMMVTIMLLVVAVMTAVPFMDHSVKSYVRTSPGLYFASYGVFLVVYIALMCCESVRRSFPANLICTAVLTLSIGYMTMMLCSMYDIVPVLLTLIITTVCCAGIIIFSMQSKHDLTSKMGYLFIASLAIMVFGFVAIIASAIFKVKFLYTIYAGLAALLFMFYLAVDIQMLMGGKKYELSPEDHIFAAIQIFLDIVYIFWMLLSIIGGSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEI3</accession>
    <name>A0A0N5BEI3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TF_AP-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEI3"/>
    <dbReference type="STRING" id="174720.A0A0N5BEI3"/>
    <dbReference type="WBParaSite" id="SPAL_0000440800.1">
        <property type="protein sequence ID" value="SPAL_0000440800.1"/>
        <property type="gene ID" value="SPAL_0000440800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="280"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000440800.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58499" checksum="E59D4903BBF25DD2" modified="2015-12-09" version="1">MEQKEGYREENNYQNGLQNFDLSGFLQMQNSMFNGGQPMFMGNGNDPLSSYNISMASNNVSQQGTSQNNQKDSDLSSNRKRRRSKEDNDQESPSKKTPNNGENDDDKESNTQSNDNNGRQTPDYLGNWYAQPQASSTPYVNGSKPGQDISNYMLGGSYYPQVNNLLQNINGYNNPSNFNNGYQYGSYNQNLFGISQQSFVKKEDPNNDSNNTNTSDESSSDKIDDSGVGCDGQTTFENQSSKGDIDGLKLSNGMVATHNPFNPSEIVTSNPLNITPNTIFCTVPGRLSLLSATTKYHVTIAELQRRILAPECLNASILGGILRKAKSKDGGKMLRQSLSQVNLALPAGRRKAAKITAFTSLVEAEAVHLAKDYHYMCDKEFPAKEIGQFLVNNELQTNTGVDKLKQIFEHTRIVINLVCDLLNKDNSPIEGIKKDQVLSDCVQNPLTRFSLLTHGFGSLSLLGAFGVLKNIIDEGSKHMDACLQQSHLNLQQTFGLPIHNQQQQQQFSHQIPMGQMSGMNPNFNGFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEV9</accession>
    <name>A0A0N5BEV9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEV9"/>
    <dbReference type="STRING" id="174720.A0A0N5BEV9"/>
    <dbReference type="WBParaSite" id="SPAL_0000452800.1">
        <property type="protein sequence ID" value="SPAL_0000452800.1"/>
        <property type="gene ID" value="SPAL_0000452800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000452800.1"/>
        </source>
    </evidence>
    <sequence length="933" mass="105640" checksum="EC9527B6EF483919" modified="2015-12-09" version="1">MATGRKFAVNDLVWAKMKGFPHWPGKVIQVPKFNGKGVDSKYMVIFFGTNEHAYLKDTELCHYLENREKYEIPNKKKSFELALKEVREAAGLDPGEPFTAASSTETSRETSLSTNQEPKEKTKRKVDDNEFDHNEFNEHSDLYEDISPINQNSIIPNIFGGSHSKKDEGSFDFNDLILPKLRGRTKSCSTRKSNEGSFSAYMERARQTFERCSGFKSKSLSSGGSRKKRQKGESFSFADNISLFDYSDLDAINPTILENLDLDLNLIGPTSRSRLPSEISGTSKRNDLQNLFKSPRDRIPSISQNSFGGLSIGSEFFSKRNRLISGTSDFNFDAEFNPHEFLKLLDHPNGVYSDSERISIVQQSDLIEGKNCTECGYSCYICNDRYKCARESCQAYNERVPADKLSLRKDDRKTKEEIEDQISGNIQFRGTRKRPHSNKSMYDTTGRQSSGSNSHQQRSETSPNIVAVIKREDGKRPIKVPKLDVVPLVKQKKKYKTKSKRPVGRPRKNPTPIPSNSIAKSSSLYNISNGNLVLDPSKKSKIWHSDPRLSKEVELQTKEKYKVLHKKAKFTPPAGFGGIRLCFICQAQVRPQQSTKNKHRWRCIGKNCRKWYGWVNPGDEIPLDFGNRGHWKGLNFSILRICKNENNTKTLKYVSFVDFNGKTGEVVRLPNGCIGRIVRRCFNVSDLSEAGVTEKNFDGSIIRPRHMMNGYDVVSKFNKNGLEIHRSAFTATLPDSRSSMCRTGLGISDGLGNFYGYKPNPIYTGRPSNVERTVLTNIKNDSDCFVVEDDKSPDSDYNLIDPFSQSKIRKVSDYLNDGNQGIKKTIRTIVDPTNSKTLNIPSDLPVPVEEANYEMNPGCDPEIITKIISQRLDILSKQDWDEENQGEVVDKLLDMTLCIFPPLLKIMANFTEGLMLPDETERELANIAVNRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFY1</accession>
    <name>A0A0N5BFY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000489000.1">
        <property type="protein sequence ID" value="SPAL_0000489000.1"/>
        <property type="gene ID" value="SPAL_0000489000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000489000.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="37159" checksum="1140A5045C700847" modified="2015-12-09" version="1">MDLLSLPDHLKLQILKELDWKSLMSLKLVCRDFYFPIEKNTENLDRPKITDLAISFDGRVIQHLHYKFKTGNSFNLKSRWKHYVPESEEQHNCFLKERNFTEIEELLFFDDEINECVRVSELNPHQNGFDGYLFQIYDDNGNNGIEMREVIVRVSSNIGRKMFWYDSYLELDAIEELANSEINRSKTIAVNFVIDYLTGSPSFGYDNDLIVSEEPLFMDIAAYLLEYGYFDFEGRCNRKKIKFNFFHDIDFTILEEDFNKYLFDEIKSKSNLVEINDEDDEFSIKTTMDCQICRTKHINRVFLSQFEGIIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG54</accession>
    <name>A0A0N5BG54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYTOSOL_AP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG54"/>
    <dbReference type="STRING" id="174720.A0A0N5BG54"/>
    <dbReference type="WBParaSite" id="SPAL_0000496200.1">
        <property type="protein sequence ID" value="SPAL_0000496200.1"/>
        <property type="gene ID" value="SPAL_0000496200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF4">
        <property type="entry name" value="AMINOPEPTIDASE NPEPL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000496200.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54000" checksum="0F0A3FCBA6009094" modified="2015-12-09" version="1">MDPINTFTFGSNIRSNEDSFLIIFIHEAIAKTLNYEKNIETAVGGRLTKEQWNMTIKKYTDLPHVVFDANSTVISILKNNGNLSRYNTPIQSKVVIDNFTNLLTLNSLKNVDVVMFLDDDKVYGTITAVVKTFYPYCEKSSNGSRNVNFCIYKSTSHGIVKATTEEYDQYNNLINGIQCARVMTETPGNKMGPDYVEEYTRKVLSNVKGLTFDVIKGSQLKERGFGGIYSVGKGAAEDPRLIHVKYKPELDSTDPPIAIVGKGITFDTGGYTIKGRTAMPGMKRDCGGAGAALGAFYYLTKNKSPLTIHLLLCVAENAVGPNATKPDDVIKMLSGKTVEVNNTDAEGRLVLGDGVHYAKEMLKCGTIIDIATLTGAQTYASGKFHCSFMTSQDDSEKELIKAGKESGELCHPLIYCPELYMLDLKSKVADMKNANLGNMSSPPSSLAGHFIGAQIDQGKGVKWIHIDIASPANYQEYATGFGVSLLSCFLTKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGF7</accession>
    <name>A0A0N5BGF7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGF7"/>
    <dbReference type="STRING" id="174720.A0A0N5BGF7"/>
    <dbReference type="WBParaSite" id="SPAL_0000506400.1">
        <property type="protein sequence ID" value="SPAL_0000506400.1"/>
        <property type="gene ID" value="SPAL_0000506400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894469" evidence="2">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000506400.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30788" checksum="1A7F7BA051835678" modified="2015-12-09" version="1">MMKDFQHFFTILFLINFVFGQHFSKDRQRQHGVKTQIAHRIFSDYDPTLRPPPQEGSEHNSIIVMTSLVISNINLKGQMADIDVTLKQQWLDSRLSYQVDPREGVDEIKIDSSRIIWTPKTYFSKAKLITKEPLDASYVVEPSGFIRSKEKVTLQTSVDSTPSFPFTSNKEITLKLSSKEHSIEDVAYVWSHAPPALKPVTVFDFALPVGYSFKEAYAGDCVGNYTIGSHSCIYVTIHLESSSTQFMITSFFPSLLLLISSWFHFFILPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGJ0</accession>
    <name>A0A0N5BGJ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGJ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000509400.1">
        <property type="protein sequence ID" value="SPAL_0000509400.1"/>
        <property type="gene ID" value="SPAL_0000509400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000509400.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27554" checksum="634293A4FB9FD834" modified="2015-12-09" version="1">MNPSTSIDNFQDSNKEIKTEDIMEISPTTSSSLNNRTPMNVDKDILRSQGSTGNQISEGTLYQGIHLTDIQFSGYTVSKTNGNHLTITLLNITPDPRGYRMSVDEVQRDNRIIDPVEEPNTSSQRPPDMQMDDYVVTLLNFLPRETIEKVFSESRRSACIKLYKIYYFLRDMNNHIITARAFAETVSIFFNLSPPILRKDIPNYLRPHVVDSLKDVKELLFTSLETEPEKVRAAFTYFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGL0</accession>
    <name>A0A0N5BGL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGL0"/>
    <dbReference type="WBParaSite" id="SPAL_0000511300.1">
        <property type="protein sequence ID" value="SPAL_0000511300.1"/>
        <property type="gene ID" value="SPAL_0000511300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000511300.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="10882" checksum="BDDBB9400D7F5ACE" modified="2015-12-09" version="1">MKLINFIYVVGFKVDVRLAVVEEGVDELEVVVGEELFGVVETSEGLEVVVGAGVVDGEELRGVVETSEGLEVVVGAGVVDGEELLGVSEAVEGVVVDGAFVVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH26</accession>
    <name>A0A0N5BH26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH26"/>
    <dbReference type="STRING" id="174720.A0A0N5BH26"/>
    <dbReference type="WBParaSite" id="SPAL_0000527100.1">
        <property type="protein sequence ID" value="SPAL_0000527100.1"/>
        <property type="gene ID" value="SPAL_0000527100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="249"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000527100.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55017" checksum="9E7D3D343090C11B" modified="2015-12-09" version="1">MSISLDNIYEIYEKGCKHNDHGNLKMASVFIKEAIKACESLIDNSKTSKDRSNAIQVLKIMKDHEKSIDELEKKVDDIGKLIRCQSSLEPTPSDPLPQQKSTKMTPIQGKTIKSRVTGRGGSTNSPSSINSTPPISAKKGTPTGGKNKGYVSRETKAKAASNVASSYDSINKNEEENSKGENNEQNEQSEFVSLQSPELVESVKTSIKDENPNVQWDDIVGLDQLKTSLRHSIVVSKILPQLFVGIRRPTRTFLLYGPPGTGKTLIAKAVATECQYKFFCVTPSVISSKWRGDSEKLIRVLFDTAKSYAPSILFFDEIDSITLKRGKNAEHEATRRTICEFLVQFEEISKSDETKVYVLAATNRPWDIDEAVLRRFEAKFYVPLPDEASRATIVRNAMREIHLSDEFSFENVAKKLEGYSASDIVNICKTAAMIPVSEFLKSISLSDMASLQDKGGCPQLPVSEEHFDRAIDQTVKSVSKDSLEDYTKWGNNCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ13</accession>
    <name>A0A0N5BJ13_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ13"/>
    <dbReference type="WBParaSite" id="SPAL_0000594100.1">
        <property type="protein sequence ID" value="SPAL_0000594100.1"/>
        <property type="gene ID" value="SPAL_0000594100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000594100.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52113" checksum="7C893E5F2B4A3BF9" modified="2015-12-09" version="1">MEGRSTDWYSIYMTYTMMLLSGIQLTIYYTSVWPYILLLNPSSQISLLGYVIASFSLGQAIGSPIFGGIATKLKSNKIPITIGLIIVIIGNIIYAFLPDLPKDNIIYWICLSRILVGIGSGTNGVLRSYCVTACIPSDRRRVVALSIASFVMGVTIGPVLQALFTPLGTGNNKYLIFTINMFTMPAIIMSIIYILGITYFWLRFKETFIGFEVVSSSDNLEDCKENNKIELPKFDNIAVIVCIIVMFVQSSVSTNIEAVATPLSIAMYNWNDAEAVLYNGLLIAASAVISFSNYMMQAFTFVHNIDQRKLLIFGLSVFFIHHTLNYPWSFYSGKLDYIPTDENRTEFSTADFGGCSHKYEWCSYISRVPLLVYCITMIVCLGFGFPYTAAPNNTLYADILGPRRQGLMQGIFELFGSIARMVGPLIGTYLFNISGPVYVMMLQGLLILLAIALILIFYKRLIPLKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJZ5</accession>
    <name>A0A0N5BJZ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000626100.1">
        <property type="protein sequence ID" value="SPAL_0000626100.1"/>
        <property type="gene ID" value="SPAL_0000626100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000626100.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10187" checksum="7FD514695F834171" modified="2015-12-09" version="1">MLTTLHLLRWQKALVTMKDRYFFNSIKNNIVIDEFTKTDASQYTVLLQSISIDVGIVDDITFGLVHHIKNLQSTPNEKNTKCTEQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLL9</accession>
    <name>A0A0N5BLL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unkown protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLL9"/>
    <dbReference type="WBParaSite" id="SPAL_0000681500.1">
        <property type="protein sequence ID" value="SPAL_0000681500.1"/>
        <property type="gene ID" value="SPAL_0000681500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000681500.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18059" checksum="E80D8F691BE9EA21" modified="2015-12-09" version="1">MQQHYYQNYEDDEIITREDEIDELDDDAIFQQTSYPPSNGNLTPLIDKQVIITTFLNIIALIACFYCLYTDQRIDGVISIFVVFFTIFIFLLNIYLWFKCWLKIREAKQEYLGNLEFSEFVKNVSSQDLITDDTGSRSFFNIPKRSNNKAIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLP7</accession>
    <name>A0A0N5BLP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000684300.1">
        <property type="protein sequence ID" value="SPAL_0000684300.1"/>
        <property type="gene ID" value="SPAL_0000684300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000684300.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7714" checksum="0AF8FB4C2ACEBA55" modified="2015-12-09" version="1">MYCGMASIHDKEERKVYFGTVVEAINGRASHWANGNQRTNFNTDDVETFWKSSDFILPIVEATENASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM09</accession>
    <name>A0A0N5BM09_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM09"/>
    <dbReference type="STRING" id="174720.A0A0N5BM09"/>
    <dbReference type="WBParaSite" id="SPAL_0000695500.1">
        <property type="protein sequence ID" value="SPAL_0000695500.1"/>
        <property type="gene ID" value="SPAL_0000695500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000695500.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18063" checksum="A2A04649ADD30C90" modified="2015-12-09" version="1">MNMLLHFGLKEYILFDFWKTGSFSGIFGSMVIIFLIGFLYEGIRKARVWMAKYEAREKNDGIASENYHQPLTPEVRANSNIPSSVNTTPESFKKTIPFYRIIHALLYGTQTTISFALMLIIMTFNGWIIIAALLGLTIGYFTFNKTPLEEMSFSNNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM50</accession>
    <name>A0A0N5BM50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM50"/>
    <dbReference type="WBParaSite" id="SPAL_0000699300.1">
        <property type="protein sequence ID" value="SPAL_0000699300.1"/>
        <property type="gene ID" value="SPAL_0000699300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000699300.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32934" checksum="DB62E32342D99258" modified="2015-12-09" version="1">MAISIHHHTTSTTNGKRQNPLLCAMPNLKARKCYFLTDDLIQVHRSHQDLSIQQCKAVVAFKHRIISKMPPCHSQSFPITEKEITEFRNIFCDLMARFTDECLYLTYIDNCICQRENSDCSAFHTLPELFVVYLITNHIENTADCGCSIGPSNAHCWNFCNFTDAQKAFVFYWLRIKDVKIPPELLKQEKDVSYGKKLIQAVKKKIGFMFQRQYLLDELLTENVNIYHKENIWTKQDVQDHIKRIMALEKREQNCTEEKGSQESLDSSKNNSQDSWNKEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMN9</accession>
    <name>A0A0N5BMN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000717800.1">
        <property type="protein sequence ID" value="SPAL_0000717800.1"/>
        <property type="gene ID" value="SPAL_0000717800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000717800.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21892" checksum="D5D2A4B1C871063F" modified="2015-12-09" version="1">MGTLATLENWKFVLIDVFINSIIYSTTIIVSIYKYVKYIKRVSSKMSEVTKKLHLDFLKFIIFQSSVPFIITFTSIFIFLIYAQLGYSNKIPFIGDILIKFMCAVPSINAILYIFLSSKNRNKFFLIVKNTLQRKSLSNISEPFIISSQRYSIDPITNIKGSRVNPCNFSGYTNLHRNSAAFYSRKVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN33</accession>
    <name>A0A0N5BN33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic recombination protein REC8-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN33"/>
    <dbReference type="WBParaSite" id="SPAL_0000731300.1">
        <property type="protein sequence ID" value="SPAL_0000731300.1"/>
        <property type="gene ID" value="SPAL_0000731300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000731300.1"/>
        </source>
    </evidence>
    <sequence length="1230" mass="141053" checksum="853D5C1B0FC59E73" modified="2015-12-09" version="1">MFEQNLSLLQPGGRFNVIWLSGDPVKKKKLPEKLRKKMFNCDLKVIIAELRPYTLNFRRDGRFNRDFAMPLNVMHRLVYGTLKCIEVSLDVMTLRVKKLINTEMHLLEEEKKFGIAEQVSYMLLGDEDTTSEADENVSGKKRKRGDAIFDARDIEEIYYSHINMDFSNMQIDETSIPISNETSRFSRLTLGPNSIKETNEREKRRREFTELFDVISEAGRTNNHLVEAAREAFSMNPLLSEVFEKKIAGNTDGLEACFDLILDDKAAQTEFYLQKLKLMDQNMINDECIAEVSRRSGKSLSIRADNVIPQDIYAELTSFIKGKSTLNLVPSTFQVTRDDIHESMSVLPTDIGQSLFVTEEPYVPFEESLVAPTVDLEVPHEVAAQEESGNTTVAQPQTEDGFAVPRPVKQKKNPPPSRNRQQRRQIPCSLDVVASMRTLEEILQFFKRRKTSSSSKFTQKLKDYSEAAAGFVKRLLDKRGSKYVQERIESTSWFKTLDDISEEVYNTNGCRLNMFEKLQQLPFVYGEKSFTIESAYDSDLKKILRDLNEPKIDFGIYAAIVDMPIIGMSNNHPNREIINRWTNINQLESSFSQSSVHSNGSRKGFDFLPKCLPMFYRYPDFTHSLKTLCHPYDKLKYPFLKKMSQERGLYHRHSKLPNKKLRKLIQKDIGIWDYSDNVDVIEKMLKCVVFPDNVLCARFHNLQPFEGSGFLTSKAVKTFAYKPNRAIVWSDLIGFLDSLFKIYCESEDNQDDKSNLTSVFLNKLFQSPPEHKPLYQESCEEVEYESRMYEIHNALILEYKQVDNYHNNKSSGKINSKFEKLLPTILDDQTSIFEEVDIADILDDLETFDLEMSFGYIPVSVKNPEQPNEGKTFDRTKTRYEVYKNNSSDLRTKSFGSSQLLVPNNWNDILTNYLSRDRKRHNNDFVSLQGGPKRQRFGISLPETPDRNFPADGDLTEVPEIESNVVSRAPSTVGSVTFKSLHDKGNDNTSEFSNGSIVVKKIGGGDIHPIAEEINEGNFEPPKESGLASIPASVIDQQETNDGLGEHETEWLDAPLSPPQFPQEGEMPEILQQPFVTMDEKRREVEELLRRRDVVPRNQNPLPYDTRREGESPDEAYLRIARHQLGPVDSSLAEEESLPDHNPESESSNLFEHITLLNHNESTEDTYEKIKVLAGKSKKLNFKDLVKENPTRQSVAKTFMNLVLLGRGGTKLEVYQKNPHDDIKIVVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNT8</accession>
    <name>A0A0N5BNT8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNT8"/>
    <dbReference type="STRING" id="174720.A0A0N5BNT8"/>
    <dbReference type="WBParaSite" id="SPAL_0000756600.1">
        <property type="protein sequence ID" value="SPAL_0000756600.1"/>
        <property type="gene ID" value="SPAL_0000756600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036639">
        <property type="entry name" value="PMK_anim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="10"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000756600.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23354" checksum="71014F9575510CB1" modified="2015-12-09" version="1">MVIIVCMSGKRKSGKDFTCILLAKLLTDREVSVEIRSLSHPLKDEFAKNNNLDACELKSSSHYKEIYRRRMVKWGEDQRRIDPHTFCKKTMENPIRSDVIIISDCRRKSDIEYFQETYTNSVVTVRMIAGEKSRIKRGYEFTSGIDDAETECGLDDWPRWDILVLNNDEDVEEQDFPLDAYLYKIVELVIAMKKIKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP26</accession>
    <name>A0A0N5BP26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP26"/>
    <dbReference type="STRING" id="174720.A0A0N5BP26"/>
    <dbReference type="WBParaSite" id="SPAL_0000765400.1">
        <property type="protein sequence ID" value="SPAL_0000765400.1"/>
        <property type="gene ID" value="SPAL_0000765400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000765400.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41172" checksum="D7E7030784DD23D1" modified="2015-12-09" version="1">MQQDRIQDSLLNAVETAKEAASSGLEKISDFFHGDPFESYVGKKVELATDATVLSTENWGLNIEICDIINTTTDGGKDAIRAIKKRLNSEMSKNNAIVMYTLTVLETCVKNCGIHFRTLVCCKEFVNELIKLIGPKFDAPQVIQERILTLIQSWAVAFKDIPELHDVVDIYNDLKSKGVQFSDIDINQIPPINTPVASVPKAFPQDIPPVQQIVNPNVPQTFLQSAGGSIESGGEVNADMLAKLRSELDVVKGNVNVFQDLLRQLQPQSTGKEEIEFLNDLYETLQEMHKRIVSLTQVIQNETVFSELLSINDEITDSFEKFERYKKNTREEKVDNAGSSLIGESMKDEESSSYGGGYNDKSNEEKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPS7</accession>
    <name>A0A0N5BPS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPS7"/>
    <dbReference type="STRING" id="174720.A0A0N5BPS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000790300.1">
        <property type="protein sequence ID" value="SPAL_0000790300.1"/>
        <property type="gene ID" value="SPAL_0000790300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894837" evidence="6">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="52"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000790300.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33215" checksum="3EFEEB258567EE71" modified="2015-12-09" version="1">MMFNILFVIFFLFQLTSLTHGNAKLRSVCGKTPNVENGYKLKDFEGLESSRIVGGSKALNNSWPWMGQITDKNGSQICGATLIGRRFLITAAHCFGDSKLKSDSHNDYNILLGSNERNKGEKYDIESISIHPYYRKNFIAYEYDIAIVKLTKPVKITQQIAPILVSKNPVSRDRICVVAGWGMTSEDGKQSEFLKELQLPVLSNEICNDFMHYRGLVNTLSSFCAGYSDGRDDACKGDSGGPLMCLDNDSWEIHGIVSWGVGCAKRGYPGIYTSVYLVKSWIFSEIIKLNSKIGNVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ37</accession>
    <name>A0A0N5BQ37_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ37"/>
    <dbReference type="WBParaSite" id="SPAL_0000800800.1">
        <property type="protein sequence ID" value="SPAL_0000800800.1"/>
        <property type="gene ID" value="SPAL_0000800800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733441" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000800800.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45018" checksum="38390866968F11B8" modified="2015-12-09" version="1">MIFIIILIFLSNLVFFIDSTNFVLGNNLSNDREKRAVLRRKNYLWREKEIVVHISSMLNENVVKLALYRISMETCLKFLLTRNPKKAIFIYQPGKYHETVLGRRKVIPQRINLPMGKEEVGKTMRETLRALGFDYEHNRNDRDKFISINETFIIPEFLKYFRKNYKGSANTYGFGYDYRSLMHFKENEYGIASRIVITAHNNYMQLLMGKSERLTFNDAKLVNKVYCSNLTTVFPPRCYNYGYQHPKHKSSMCLCPPFVHGTNCQSWLSNHKFCTINNRFVATRKKTTIYPRVAGKCTFYISSSYGSKIMVKLGFDKVRPHTFICKENNSVEIRFQKDLSVSGILFCPGNYPLKILSQGNLVIIQSNLPEVTMRLKIKYWQYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ59</accession>
    <name>A0A0N5BQ59_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Basement membrane proteoglycan</fullName>
        </submittedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BQ59"/>
    <dbReference type="WBParaSite" id="SPAL_0000802900.1">
        <property type="protein sequence ID" value="SPAL_0000802900.1"/>
        <property type="gene ID" value="SPAL_0000802900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05743">
        <property type="entry name" value="Ig_Perlecan_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001694">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000454">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15 18" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894697" evidence="20">
        <location>
            <begin position="27"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="272"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="21">
        <location>
            <begin position="380"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="23">
        <location>
            <begin position="455"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="21">
        <location>
            <begin position="632"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="23">
        <location>
            <begin position="745"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="21">
        <location>
            <begin position="953"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="21">
        <location>
            <begin position="1009"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1188"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1310"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1403"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1500"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1600"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1694"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1788"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1877"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1973"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="2063"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="2182"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="2251"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2344"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2442"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="2345"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="2442"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000802900.1"/>
        </source>
    </evidence>
    <sequence length="2464" mass="273389" checksum="C7BB4E651DFA7942" modified="2015-12-09" version="1">MLQRRLASFLLVAFIVICAISNLILASRHHNTRNKHHATDQEIHISVYPPEIVSRDGKEASFECRARTFDNAYYPEVKWTRVGGPLPTSAWESSGRLTFNPLSVEDSGRYVCVATHEGKRVEAYVNLHVQHYGPQALQTEYNTPFPSRGTCSSNEIKCGDNDCIKKDYVCDGEPDCGDRADEANCPSTKVCEPNEFKCGNDRCVQKMWLCDGDDDCGDGTDELNCKKKNPGDLCEPTEFKCADNRQCVPQSFQCDGTNDCQDGSDEVGCVQPTVVQPPETNKQVPQGSTFSLSCRAVAVPEPYINWRLNWGPVCEPPRCLQHSEGGVGTLTIHDAQPLDQGAYTCEAINVKGRVLATPDCIVRIVNIPAPQPPPALPRHQCDPIGSATTFADPHTGTCQCKPLVTGPSCNQCKPGSYHLTEKSSHGCLKCFCFGITDQCTSSRLYRTKEKLLFDGDSEGVVLTDRHGIQVYNEHNFDFGKQGYLTHYESDQGREVKYWKLPQRFLGDKVTAYGGTFVSHLQYTGHGHPINEPVIILKGNRITLVHKLKPGVHIRPNEPNIIEVETYESNYEHESGQPASREDLMMVLADLDQVLIRATHAYGQESTSLGDVNWDIAVDRDTQGEFALEVEQCRCPPGYIGTSCEDCAPGYERSHTGPYLGTCVPAAPRAPTCSSGAISQHSQHTGYCQCKPQTTGQRCDQCSANSFYLSPANPQGCIPCFCSGVTNQCSSSSLRRNSVKIDYLHGDMDDLQITSRDTVNPLVPESAALIEQGSITFSSFPEARGQTLYWKLPQKFLGDKVTSYGGSLRYSFKFNCRGSPNMDPDVIIKGNGITLQYYARQQFHPNRENIIDVKIFEDRWSRVDDQVATREHLLMALADLDEILIKMTHLSECTESSLISVSLDYADSYGPGVPALEVEQCICPPGYIGTSCEDCAPGYTRSGGGLYLGICERCECHGHATECDKEHGVCLNCQHNTEGDNCERCKPGFVGDARRGTPMDCQPEQAKPPCECHNHSPRGCDSYGRCLFCEHNTEGFHCETCKKGFYGNATVGTPYDCNLCPCPGASDCYIGPNGQVQCRNCPAGYYGPLCNECAPGYTRSQKTGGRDCEPIGRIHEDRIEFVPSQEGINTRTDPSMSLSNVRSNYRQSIPSYKDSQSSYLSRAQKQQNVVFVSEKDSNFVSVTATTNTPRIGVRPVQRTHKRIGEQRQRRTRIHVHGLRVEIEEPKFLQLTQGQRVKWNCRVIEPAPQNVVITWSKVGSMYLPHGAQQRGNKLIIESVEPEDAGQYRCTGQAGNKIATDEANLIVIRGEPPRPVVTPPEQTVNEGESATFTCTVPGLANCEVRWHKEDVGGPLPHGVYPHGGTLRIPHVQSHHAGNYICTAVNQYGLGQSNPGKLNVVKHKVPPRVEPPVLNVDEGEPARFRCWVPGNARAVLKWTLPDGSPLPQGAEENNGYLNIYRTIKGIHDTDYLCTATDPNNPYEAPEPAPLARLNINEPHEPIRPVIDPIEQTVPEGTSAKFRCWVPNHPEINVRWSQRNGAPIPQTAMDDRGELIWRQAHTTDAGDYICTAFDPVSRQNVPSEPATLNVVAKVIPQEAPRMGDPVVDPVDQRVKLGDPARIKCYVPGTPNAHLRWQKADGQPLPQGVYEDGRGLLYIYKVEKHHEEEYVCIAQDPNTGDRKESEKAKINVDEPVEGKPPIPTASPPLLTVKQGDPATFECEAESDTPVRFTWGYIHENGQLPEGVRAEGEKLHITNAEEHNVGDYVCIATNEFGKGVAPPVKLEITEESLPPTARVEPRVWNGKPGDMHKFKCIVTGSPTPTIQWTGPNGEELPEGTEIQDNGVYLVFENAKTEYNGEYTCTAKNDIGEASDTGIVNIGSPLIVRTNPPGPRIVLTVGEPLEIRCEAFGEPEPEVEWLHDPGPERGDLPDDYVPVTISEQFIKHPGVGLGNSGRYTCKGSNQIATASKDIYIEVVEPSQVATVAILGGSTQYLAHGQQARIVCTSTGSNLVDKIKWINVHTGEDVESNGDEGVLFIDSFDDHLAGDYKCSGYRNDKEIASAKVTLKPDSERSVDAIQVEIAPPSVRVVRQGESVILECVMHGDNDGKMKYKWSQLRRGSLVPNIKQTSQLIIKSADNSQDHGVYRCEVLDEDGELLGSAYTAVSVGHTSDEQASIYPLEEESDGEVECPIFIVPGSHVEWSKQDEGELPDNAHVQGTKLKFTNFEEENSGIYVCKVTMENNNEVEGYAKVQIYVPDTVIQVRIEQSTDNPTLGERIWFDCIVTGDNTATFEWSKEESDHLPEGTHVEKGRLVFNELTKDDSGTYWCQALTKDGMLRSKAVLNIGEVSGKRKRKHLNPKNKSKRNYSYYHNSRPVAKSYKHDYKFNKDHNNNRDKSNKMHATYTETHRKLTIHHSADDYKHNNLKSKHNYMNSGKYGGERYNNYKHYRGNRNTPRHHSKEVFGGWFESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ71</accession>
    <name>A0A0N5BQ71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3883 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ71"/>
    <dbReference type="WBParaSite" id="SPAL_0000803925.1">
        <property type="protein sequence ID" value="SPAL_0000803925.1"/>
        <property type="gene ID" value="SPAL_0000803925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000803925.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15931" checksum="2A554A44DDABEE34" modified="2015-12-09" version="1">MEATDEGIKDIVHQMRERCFGLDRGDRINNVELRRFLDDIRIKRKAQELIRNEGKICKSEIAEPALGRWFRLHYNSHEIYLVNTRTGDKTNRNANINFYKLEDKETFFSVVEIVFQETDMGVEEGIGKKSFFLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQX8</accession>
    <name>A0A0N5BQX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQX8"/>
    <dbReference type="STRING" id="174720.A0A0N5BQX8"/>
    <dbReference type="WBParaSite" id="SPAL_0000828600.1">
        <property type="protein sequence ID" value="SPAL_0000828600.1"/>
        <property type="gene ID" value="SPAL_0000828600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23219">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE C15H7.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23219:SF13">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000828600.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33876" checksum="B248C1803BC74757" modified="2015-12-09" version="1">MRNQSFEGKSNETVGEFSSMRKSRKSSNRIVNYAENFFKTISNTPIEELKSNFDKNSFYCDPNISVNAFVANKSENRFDDIPCIDSTRVVLDPTIGSSDGGSELSDYIHANFVNIPGLTFKFIATQLPLKSTHNNFWRMIYQENVETMVIFCDEEEIKNNEDSPQKLFPNQNNENMQLETIYLMNKKNGTTSGLPHSIVEVLPNGPSCVLVCNSGIGKCGAFMLIAAMKGCIMLNKPINGVEIMKMIRNQRAYAIKSFKHHIYAYTVIMQYLKIRTKDEFKNEISYFFNKSKRYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQY2</accession>
    <name>A0A0N5BQY2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BQY2"/>
    <dbReference type="WBParaSite" id="SPAL_0000829000.1">
        <property type="protein sequence ID" value="SPAL_0000829000.1"/>
        <property type="gene ID" value="SPAL_0000829000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="941"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000829000.1"/>
        </source>
    </evidence>
    <sequence length="1099" mass="119075" checksum="29A4A373C448D857" modified="2015-12-09" version="1">XEYTYSTMTEESETPASYSEYTEFFEPTATKETVGSESTVSGETEGTLVTESTVSGETEGTLVTESAATKETVGSESTVSGETKATGSEETETPVSGNTEPSEYTYSTMTEESETPASYSEYTEISGPTATKETVGSESTVSGETEGTLVTESTASRETEGFESTVSGETEATVSEEAETTETRVSGMTRSTIFVGFESSETPIPGNTEPSEYTYSTITKESETPASYSEYTEIYGSTFTKENEPSESSVSGETETTGSQGTKESITTEETGTTSGEVSETTQIQTSCVTETAQTVETEKYESPVSYPEYPGTTEFENTKGTGSSEATRSVETGATETKETEATYNSYSGESDTPVSYAEYTETQETNPTSEPELTVSGETEGTLSKETETTEMPISGITESTMFESFRSSETPASENTEPSEYRYSTVTEKSETPASYSEYTEISGPTASRETAKSESTVSGETEGTLVTESTASKETVGSESSVSGETETTLSEGTKTTSVSMRSSEFTYSSFYETSESVGSSEPSGTGVTSSTIPRETETTESPASKETEATVSGEPETTISEESETSEYPDVTDYENEETSATYSEYSESTEPNAHIETRSTGKTQSFETDTPVTYPEFEETRVTTDDDIGETTIEELGSSEFSTPLVQKESETPESTSFTEEPLASTETDYDIGRTTTEEPGASEYTEETETPSTYSEYSESTLSQKTEPAISQTPESEGSSYYETDAPATYPEYPVTSESTDNQSTESKNTTECEYSDKTDIPAIYTDYPEATSGTPTNKPSKTPKPTKKPTKKPTSTKKPCVSNDTECEYTDENGTSAIYTDYTDKITPTSTKKPNVTKTPEEDCEYTDQTKQPDEYTDYPENSRSTAKPNRTTEPPRPVKTTPIKTTKTSKPTKTPKPSTIRSTRPRTTTPTTKTRKPTTPTPTTKRIETTKPNKPNKPKTTTTKSTTTVTTTKATKPIRTPKPTKPNKPKTTTTESTTTVTTTKATKPIRTPKPTKPNKPTTTTTKSTTTVTTTKATKPIRTPKPTKPTRPPTPIKTTTPRKTSTTSESDSAGSSSPSTPEDQYEYPDYKYPEYTVDMKLLNQDGNQMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRV1</accession>
    <name>A0A0N5BRV1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COX6C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRV1"/>
    <dbReference type="WBParaSite" id="SPAL_0000859600.1">
        <property type="protein sequence ID" value="SPAL_0000859600.1"/>
        <property type="gene ID" value="SPAL_0000859600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000859600.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8722" checksum="5CC10F2797CB41FC" modified="2015-12-09" version="1">MGFWPYKSSLTEYGRVLFILLTGTIVGSKCVTYYYEPLKNYDKLLDEGKRDLLVKYRAKHEERLKRLGISKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRV4</accession>
    <name>A0A0N5BRV4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRV4"/>
    <dbReference type="STRING" id="174720.A0A0N5BRV4"/>
    <dbReference type="WBParaSite" id="SPAL_0000859900.1">
        <property type="protein sequence ID" value="SPAL_0000859900.1"/>
        <property type="gene ID" value="SPAL_0000859900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18101">
        <property type="entry name" value="Trm10euk_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000859900.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33455" checksum="214DDA20983C4998" modified="2015-12-09" version="1">MEIQNSAIETTIKDDTVNTTDDKTRKVKNESPNPLSKNQQKKLARREKYLEKRKEKRILEKERRKERHKKMRENNIPIPSRKNFKKMADSNCKVRVAIDMSFDEYMTDVNIKNTVTQLSFCYGYNRRAQNPMQLYIVGLNGKGNEEFLKQSDNDSWDVHSTTKSLTEMFSKDELVYLTADSENDLNDIEDDKVYVIGGLLDHNSHPKLTLKLAEEAGIRHAKLPIGNFMRLKTRSVLTINQVYDIILKYTETKSWEDAFFKVIPVRKGIEKIENTTPEKAENKVEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSC4</accession>
    <name>A0A0N5BSC4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynamin-like GTPase OPA1, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSC4"/>
    <dbReference type="STRING" id="174720.A0A0N5BSC4"/>
    <dbReference type="WBParaSite" id="SPAL_0000876800.1">
        <property type="protein sequence ID" value="SPAL_0000876800.1"/>
        <property type="gene ID" value="SPAL_0000876800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000171">
        <property type="entry name" value="Dynamin-like 120 kDa protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045817">
        <property type="entry name" value="OPA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF67">
        <property type="entry name" value="DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19434">
        <property type="entry name" value="OPA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="21">
        <location>
            <begin position="240"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="854"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000876800.1"/>
        </source>
    </evidence>
    <sequence length="919" mass="106054" checksum="6054393606B6134C" modified="2015-12-09" version="1">MPISRYLLPNESRLTKYSNHNIIAKRAIATGLLRHALKLRYWMFGGAVSGGVATANWYDEWKKNLPDIPPWLKIDGSVTKKFGTKVETILGSWDRFKFSDKIPQLKSKAIVSEEFKSDEKKEGNSNDNNSNNNKEKVGAGMLAAFGGFTFGKKKTEEEGEEVMSQEERIKKLQEELLKVQCQYQKELERLEKENCNLKQKILLSDQTSLKYIKNVKRSLIDLYSEVLDILTEYDTSYNTADNLPRVVVVGDQSAGKTSVLEMVAQARIFPRGSGEMMTRSPVKVTLSEGPYHVAQFRDSAREFDLTNEKDLESLRNEIEVRMRNSVADGKTVSQDVISLTVKGPNLSRIVLIDLPGVISTVTADMARETKDDIIKMAKQYMENPNAIILCIQDGSIDAERSNVTDLVSSIDPYGRRTIFVLTKIDLAEANLQNLNRVKRILEGTLFPMKALGYFGVVTGRGNKADSIDDIKHYEEQFFEKSRLLKEGLLTPSQLTTKNMTLAVSDRFWKMVKDSIETQADSFRATRFNLEAEWRNNFPRIRELNRDELFDRARGEILDEIVNLSLVKADTWEKEVRDKLWHLISFNIFDQVLMPACSVDNTGTFNTQLDIKLRHFAEKELAYKSVASGYETLSYVFTHLVRNSNNQKHEKDGIFDNLKEAVLDASLKFHSWDKKAVDYLKVIQFQALDDRAINDRATWEKACKFMNEKVSERLNEVRNIINEARGPSLIGSWISWTTPTEEQLLNSSIQQDLKNIISNDPEHKSGLTDDDMTIVKRSLESRGFYEVPNDIIRRQWRLIYKEHFLSKLLRVSAEWKNYYQNYKQGFNDGDIETHIIIFFHRISKMIELSSTALRQQIMSTEQRNLEKEIKSLLDEWSHDSELKKKYLTGRRVELAEELRQVRHIQEKLENFILQLREEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSD1</accession>
    <name>A0A0N5BSD1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSD1"/>
    <dbReference type="STRING" id="174720.A0A0N5BSD1"/>
    <dbReference type="WBParaSite" id="SPAL_0000877500.1">
        <property type="protein sequence ID" value="SPAL_0000877500.1"/>
        <property type="gene ID" value="SPAL_0000877500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000877500.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12150" checksum="FF148B0C8E6E1569" modified="2015-12-09" version="1">MNAYSQEVSNSPDNKNSRKLLASITHEGIFQYKVMPMGLTGSLDKFQEIMDEVLFRLPNCYVYLDDILTCASDEDIHLDNINAILQRIAEFSMKINIAKCQFGRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSR6</accession>
    <name>A0A0N5BSR6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000890800.1">
        <property type="protein sequence ID" value="SPAL_0000890800.1"/>
        <property type="gene ID" value="SPAL_0000890800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894912" description="glucuronosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000890800.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60403" checksum="786DB4B84D095ED3" modified="2015-12-09" version="1">MSLKYFILFFNLFLLPHSYKILVVNPKIGYSHVNFFSQIADILTEAGHNVTVLAIDLDPTVKHPGAYKSKVITYPTTKEVETNFLNMNDNRMLWNLSSSVLDQYKIIMNFINGIHKQSLRVFNDDELAEQIRQEKFDLGITETIHIYVLGMFKVWGIKTYVSGYSMPLADSYYKSFSMPFPASFIPTLTSPFSDKMTYYERFQNLLTHYVGEIVFYFIHNKITLQNEFDNKYGNGFFDSKNAIGDSSFLVLNSNPFLDIPGPKTPKMIEVSGIGVKDPQPLNEYWNKILSLRNKTVLVSFGTFAKSINMPEDLKNGLLKTMRKMKDITFIWKYEEPEDGTGKDIENLIISKWLPQSDLLNDERLSLFVTHGGSGSIVELSFRGVPAVVIPIFGDQLRNSKLIMRQKYGIVMDKFNLANPDILMKNIETILNDETYRNNAKIVSRRLNKRPIGSKRLLIEHIEFAAEFDRLDMLDLASHNMGVIEYYNLDIILPVFIGFFIFIYFIFIKTIKILGKLFAFKVKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUR2</accession>
    <name>A0A0N5BUR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brain protein I3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUR2"/>
    <dbReference type="WBParaSite" id="SPAL_0000958100.1">
        <property type="protein sequence ID" value="SPAL_0000958100.1"/>
        <property type="gene ID" value="SPAL_0000958100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000958100.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14936" checksum="A4E0A9A4E0884242" modified="2015-12-09" version="1">MEQNPKSANSVHDPPPPYTPQPLAPTPHPIPIAIPMPVIQPLSNPNIIVNNGNENGVRGGSGSINGQSPQQIAALINMQIVKCPFCGLGTLQRKIKYPQLIIFLLISVFLFPLGLCVWCCLFCNSIYKRSCTNCGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUU2</accession>
    <name>A0A0N5BUU2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUU2"/>
    <dbReference type="WBParaSite" id="SPAL_0000961000.1">
        <property type="protein sequence ID" value="SPAL_0000961000.1"/>
        <property type="gene ID" value="SPAL_0000961000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000961000.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28823" checksum="3CE68F256F8D02A7" modified="2015-12-09" version="1">MGDEELLNSPPRELQKSNLNNIRINPEQQNQEALNIPLINVEVQSTESKSISERNLSADNENFDGGKKEIVKARTEGKPSVDTKKKPKRLFSFEALVRAMYCGEVSALLAEHSLQGVPHRGISVERLCVPLIALIGNKMIKSGKVVDREMVELPTGRRILASVGKIKAYETRLHDRLVTTLTSKTWESIELNSFTEGQQPLFNNVSTKVLTINLRSSCINMRFVACKSAEFLWWNSMPAGREMLKHFPALKGVAYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUY6</accession>
    <name>A0A0N5BUY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sas10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUY6"/>
    <dbReference type="STRING" id="174720.A0A0N5BUY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000965400.1">
        <property type="protein sequence ID" value="SPAL_0000965400.1"/>
        <property type="gene ID" value="SPAL_0000965400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="2">
        <location>
            <begin position="307"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000965400.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43635" checksum="EFA6694FD9DD7C12" modified="2015-12-09" version="1">MVTKRFKKSAKKTPKKQEKDSVVHLSGDEDDDVSKFVERTEYKDRIPEDLELDLMESRTTAENLSKNVMIFADYDSGDSDEEGDKSKSNLLSKGSSKGSRIKKLDSENAMDTSESFTGMDDVDPTVRKYVEYLTFMENLKPIFEHFLGKLSETSRLYKLMSYYNILRNHMSCLIMFHLFKFNDGRIFDMKKEEEKQIDLVMRFMDVLCDIYPEVEQIISLLDNETENGDILKDMYGNLNAVDCEEVYAALKDSSDITEKDGDELDYSEDDQLSTDSEDDLEDRELLRELKKKKDVGDDEDVKEKHVQRRLDQAILDNKGYVPGGKKKKKTPGVKRRQQFQKASLRNRSNVPGVRKEIPKHEGEARGIKTNVIKSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV28</accession>
    <name>A0A0N5BV28_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV28"/>
    <dbReference type="STRING" id="174720.A0A0N5BV28"/>
    <dbReference type="WBParaSite" id="SPAL_0000969400.1">
        <property type="protein sequence ID" value="SPAL_0000969400.1"/>
        <property type="gene ID" value="SPAL_0000969400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000969400.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18663" checksum="50F523790F2C0018" modified="2015-12-09" version="1">MTNTKGLRRGTRYMFAREFRKHGTEHLSTYYTQYKRGDIVTVKGNGAFQGGMPYKVYHGKTGRVFNVTKRAVGIIINKRVRTRIIPKRINVRIEHVRQSKSRHEFLDRVKRNDVIKQAVKEGKQPWVELKRHAVQPRPGHFVKVKQAPTVLTPVKFEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVZ9</accession>
    <name>A0A0N5BVZ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVZ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001000500.1">
        <property type="protein sequence ID" value="SPAL_0001000500.1"/>
        <property type="gene ID" value="SPAL_0001000500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="133"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001000500.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37141" checksum="FCA0D56B8E5A901E" modified="2015-12-09" version="1">MVLNYKKYFIPNCCAKKEDDGGFITPRVKRSPNYWVLFDKRIILTYYYKNAFISITLMSLFVFILQFESLPAVYNNNTFLKNTVWVLYGVFIYLVLRIITTDPGIIPKDTFSESLRRIILEESLFMSMRAYEKNEKNYCVICHHNMPEKTFHCRRCNCCVLDLDHHCKALGSCIGKRNYHFFVLMLFVLLIINVIAFTISTLLFYQEFSTTGRSEWIYVLFKKYPLSGALQLTTLLLFFPITYMNTLHCKLISCEVGTYYYFLHTYNSPPENGMKKFTLKKMLVNYFKLFKKPTQPSLLRIGHVSDDKLSSIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWQ0</accession>
    <name>A0A0N5BWQ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BWQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001024000.1">
        <property type="protein sequence ID" value="SPAL_0001024000.1"/>
        <property type="gene ID" value="SPAL_0001024000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001024000.1"/>
        </source>
    </evidence>
    <sequence length="1153" mass="133991" checksum="7D47E556377235B3" modified="2015-12-09" version="1">MDKLIKEITCLQEWSLSTASIIQENSPKIDDALVYPLPFVPRNSFKIAVSKNSEAIVTITPDRVMRVNGFKDDKLVLKSVIKLKQDILHDQAILQYSESGQLILITRSFGFLDIFDVNGVFKNTIKVSTSTKNIFDSISCIQSVTLDDEHWTDKVFILQCNGSFMCKKLSGDGKIETVFNIIIQSNGYISSFHYNSKYNLLITSSVFLRNDKSNCKESSLIDNYGISVYRNSKSDGESFKLFSGTNNIAKKFDSFMGLISSFYKFESIMTFSINSEETNLVSLTNFGKVIISSMPSMKILQILDPTILLKNSNTFVSVLWNEDKELTLLLKTGEIYQENYDSISENMISGNVKPTLNNCLAISKKNKDKLACFNGINGPDFYPLDKKNLSDNVSLFFVLFIWIFSFFQKCYLISLKFFQKEINTKNVEYKSRKIDLSINTIKNTTFEVYLKKLLCQKNYEKAKELAKEHNCFDIDNINKLQWNEAKEPSDELLSILCEIKDKEWVVNECLKCNFSDIDFQLKLNDICNNLKWEVSEELQFLISHNNLIFQFDDWEDMEKFNQIKQMSLLDLGIFMLQEERIDICVKLITSYRKLLRPYILIMLYYIPESVNPRQYSQLLPEIKGQSQNEIDPYLFLNDYDEKKIEYFDKEKELISNSWNIIMEQNSNVIPYYLEGKKQQTICLNWLIKRVLQIDEKCGLANYSMKLSEISTERGFTEMEDYIMHCYFYLQYLLKLNGGVSSTLETFLNMDSQVIAKSVIKHMSPSNIIENIPLLVKIFSYFEGRNSNSCAENDMALIIEHCSQTSMASLDVMTSNFPNFLQYKSIEKCFCASNLKGKPLIDECQKYKIEKEVRSALIIFNQHGVTPMFSQIIESRKNQGKAWNLLMMLIRNSQCLSEQDWKYMIMDVNDIRTVIFDKVLTFEKVNQLLLDEMIELIEKVSPDKIPIHLIKNDGHLSEEKITQLILAKSNHYLNMSLPDINDENLVLAEKVLFLVPENINKEQYDIQKKQLKKVKLALKLGCKRIPTQIIFCDEEELIRELVFINDNYRKVNKLSELCMLFDTDYSKPQVIALCIERAIEMEDFQILKMYIEELMETSRNIATVFNACILLWKSKIFFEMREEILACMLLNCTSENDTQIAFDIMNCDVTQTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX05</accession>
    <name>A0A0N5BX05_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Malonate-semialdehyde dehydrogenase [acylating]</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX05"/>
    <dbReference type="STRING" id="174720.A0A0N5BX05"/>
    <dbReference type="WBParaSite" id="SPAL_0001034300.1">
        <property type="protein sequence ID" value="SPAL_0001034300.1"/>
        <property type="gene ID" value="SPAL_0001034300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001034300.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="56422" checksum="B107FC6280A3220F" modified="2015-12-09" version="1">MLSRLNFVSKKNLSFTKPASVETVKNWIDGKAVESKTNKWVDLTNPATNEVIAKVPCSTQDEMLEAVESCKKGFSVWKNYSVLSRQQVFFNYQAIIKKNMEVLKKNIVKEQGKTLPDAEGDVNRGLQVVQHACSAASLLMGETMNNVSRDMDTFSFRIPLGVTAGICPFNFPAMVPLWMFPLSTVAGNSMLIKPSEQDPGATMMLVEMAKEAGIPDGVLNVIHGTHDAVNFICDNPDIKAISFVGGDAAGKHIYERGSKNGKRVQSNMGAKNHGVVMPDANKETTLNQLTAAAFGAAGQRCMALTTAIFVGESKKWIPELVEKVKKLNVGPGWENNTDIGPLISVGAKERAINLINSAKSEGADVILDGTKCVVKGYEKGNFVGPTIISGVQPHMTCYKNEIFGPALCVMFAESLDEAVDIINKNPYGNGTAIFTTNGISARRFTNIVDAGQIGINVPIPVPLPQFSFTGSRGSFLGSENFYGKAGLKFYTQWKTVTQFWRSEDATPEAKPQLSFPQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXE5</accession>
    <name>A0A0N5BXE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXE5"/>
    <dbReference type="WBParaSite" id="SPAL_0001047600.1">
        <property type="protein sequence ID" value="SPAL_0001047600.1"/>
        <property type="gene ID" value="SPAL_0001047600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039161">
        <property type="entry name" value="C19orf47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359:SF1">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18017">
        <property type="entry name" value="SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001047600.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23492" checksum="4821180976FAEACD" modified="2015-12-09" version="1">MTLSYEAYLEEKWFQFFLESGLPKNVCSIYAASFVRNRLQCEHLLQLGKNDLVALGVEAIGDQICILKHIKDTAGKPKQFVESKITYKGANNSIGRSSLSDLDRVTTTTAVSRVGDKKTGIDKNESRNGVARRSKSFSKNVSQERKRSNSRGKSSSILDRVTLKGVSKIKNEGRKVRKSSILDRVSIGGINKKVVSKSPKRTNILDRVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXN6</accession>
    <name>A0A0N5BXN6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXN6"/>
    <dbReference type="WBParaSite" id="SPAL_0001055900.1">
        <property type="protein sequence ID" value="SPAL_0001055900.1"/>
        <property type="gene ID" value="SPAL_0001055900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000006">
        <property type="entry name" value="Expansion, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="2">
        <location>
            <begin position="59"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001055900.1"/>
        </source>
    </evidence>
    <sequence length="1253" mass="144143" checksum="7E113DD41D5C1F02" modified="2015-12-09" version="1">MFQELNNIKKYYPESIEEKNNCESIVDEDMWYDIDQFQLDHLNEVLQRLSEGTLDDEIWGKLIIMEKTKRIAKAYLRKTTIIVDGGDEEFDGMTIGFNYFTNPDRDYQTSELRKKIGDGVIIKMDSQGNIKAMARGTAPVIVQNWKNSKKHCIGEKLLRLQGKLITKRGVDMNDDDRIFKVFDMKKFKISLERDSVETEEDVKNLLLKTCLRIALVKDGHPDDPMETPCWIMLINLVALDMVKTKMPHIADLNCLYGELGCPSTIPSIKRSALREQIESSNISCNSRRRSQSYYECLSDDDDNKHHSRMPSNYDNGRRKSKRNISSSDESEESNTEVNTRYTHNIVNSRFLKPYSGSITDSSSGFASGTDKRSFNSNKRSSSDLTKSAEDLKHNHRDGKKVLNPGLKIPGIRPKLDKTLFDPPNSSRRNSSLINKGSNLHEDDYEKKQEYEELRNMEEINHINDHDLVGIDDRIYVDNERYSDERYINNNDYLETSKINEEGKDFDIGEALKNVDESFDYLQTGDYYSDSFEIEENNWRESILSPNNVVEDKSINIENDSDDTVSSKSSLSHSNKLLLLDRYRGIRKPITKSNNYLQTIDRVRSKSSKKSKNFSNSGYDVLFNRSETIKKNSISSTFPLEIVNTSCQFFRSQEQEHTIVVWKEWGCVNDKFHCNFKNSSISIVNVEYDIVRDTSLAITKNGKEIPEYKNEHITIKKLDLQPQQQSVTCLQITDTCNIEENRKININQTTNSQSTREDSETTIKNNSLVPRRQQPGNGTTILQISDSPPTTLGTTASEQQNQREHKRNLQFTNRLIISTETQKEQHQSMEINRTPVNCITSTRRLSKESSGNVSQTPSLQEQEQPLQNSNIRTTANHSKKPIYDNPFIKKPELQHQLSTTPNCITETVWTAHQPIQPPTPDNCPAGAVPARANLHGKKQDTEHGGKRQPTKESQESIKNNQSTTNRSVKSLSKEFESKTDWIGKITPTCQNTQQTVKSKFQKWKEWGSEERQRTINTTIPNILNTSQTNGRNRSLDTETYPPNRETSNRNRKSLSPTISNTSSTSTITSNGERNNLSNTTKLSSTRDLLSFSKRDSNDKEEQQREGRNIHESSTCKWINKSESSRGREEQLLYERETFESKLPINALISIFEESSVSSDISSSFKWAYRERDGKDISKESRSNEIPFNRKNDDRRNEEEWNGSKYECESIKGRDNIWKQKTNNERILGYTSSRISPCGVEECNREDEEIFVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY54</accession>
    <name>A0A0N5BY54_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY54"/>
    <dbReference type="WBParaSite" id="SPAL_0001071500.1">
        <property type="protein sequence ID" value="SPAL_0001071500.1"/>
        <property type="gene ID" value="SPAL_0001071500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001071500.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18156" checksum="A1BEBF3B93C68013" modified="2015-12-09" version="1">MFQMIVYNRFILFTAIFIIKIVGTQIIFRLYRTGITGTPMCKLSKSGFFTVFISEKIYTPKEKNPLAMEKGRYNQSFYVTGSVLSRKKPNLYVKIFHNCTNRPSRNEKVFMKTIPLQFIFYHGRLRSIYDLGKFDLSSVKSLEIIYNRRAAFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYB4</accession>
    <name>A0A0N5BYB4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYB4"/>
    <dbReference type="STRING" id="174720.A0A0N5BYB4"/>
    <dbReference type="WBParaSite" id="SPAL_0001077500.1">
        <property type="protein sequence ID" value="SPAL_0001077500.1"/>
        <property type="gene ID" value="SPAL_0001077500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001077500.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26676" checksum="BD730FE6124F0C55" modified="2015-12-09" version="1">MYPAPYIVKGQNYSIKNLFVQAVLNETIRIVKNISKNRSVKKYIYVYQKFEVDPFVENITNIEFYDPYYLCITYKNMRYYNVDGIIVWSTSKNMTARCPYIKNYTETIFGPYVKALNRTFSISTQTTISSTTSSQTAKSSCQTGSLVNNEFSLKDCNNILTRRNITEWCETSFYGPDCLQRKLNSSGIPPNLITNYIDLLMEILQNGVKQVSMVQIVYNENLILVEFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZJ0</accession>
    <name>A0A0N5BZJ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZJ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001118000.1">
        <property type="protein sequence ID" value="SPAL_0001118000.1"/>
        <property type="gene ID" value="SPAL_0001118000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001118000.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36020" checksum="3D44F54DEE29893F" modified="2015-12-09" version="1">MDTTNKNNLLANVSNQFNINVNGTNKSIRGTALNIPFVELKKIIDRNIGTYHVGNLKIMKIATFGTNIYLDDDRTINLSNEEDEVSMKIIRGNIRTLARKIVEESDYEGLLVFATFNIAKGVINGYVLEEIYKISDLDSFRKCFEREVNIIKAAVNANIFNTPKLHLLNDSNGFSRVPYEKIFEEDNNKKQVSVISSPTNFTCDSLFSTPTAPKRTENFINTNSGKRRSLDPCNLPFKRSLPSPLILNNTVNQNATSLNVNDVINAIELGLSSERSNEIELQAVRNFLGVTHIELSRHLMQLLNQYEITENMTKIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZJ6</accession>
    <name>A0A0N5BZJ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001118700.1">
        <property type="protein sequence ID" value="SPAL_0001118700.1"/>
        <property type="gene ID" value="SPAL_0001118700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895358" evidence="1">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001118700.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43033" checksum="9B3B82D5BC3D4F93" modified="2015-12-09" version="1">MKLPLLFLLPIILLISFIEFSFAINDQTIEPFCKTCSTPMIYTTMHYNPTTCTPSTKVTTCTPSTKVTTCTPSTKVTTCTPSTKVTTCTPSTKVTTCTPSTKVTTCTTKTAATLKAINQQNVFTNIVYFNNPPIEHVLKQTNIKKTKKPYRKICNLPQKTCTEIKEEFRRGKKLPYSIFDVRGEGLKSNPEDLNLYTYATLNINPIASVIKCPGDALFRHTTGIRWIPNPNEKYRQLSYDKNRLSYMIVAPDNRRKFRVNCGKIKTMPEDENSVITWNYNINVTENTYIFDIDIPANYEGSIRCSSDEKHKEGYALIFVVTSLNEWKGPTIERPQRERQINENSKIYPGEIVFIYSKKTVEDIEGLVFEPLCVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C051</accession>
    <name>A0A0N5C051_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C051"/>
    <dbReference type="STRING" id="174720.A0A0N5C051"/>
    <dbReference type="WBParaSite" id="SPAL_0001138300.1">
        <property type="protein sequence ID" value="SPAL_0001138300.1"/>
        <property type="gene ID" value="SPAL_0001138300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001138300.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="72772" checksum="37CBF9EC4D996F2B" modified="2015-12-09" version="1">MVANWEAQPEFDSVKVPKISTWIDALELRFNLDDLSETLHGTRMLTILKLKVGPLGREAIADAHATSYALAKDALKKRFDNRMSVEAAIMKLSMARVDYAPDKFGESVRAIGDLIDATIPDLAAASKLDVISQRLLSILKGHVQRRLLDRLGFYKSLGDLYTDLEFNNQMVNNFPNGRRPLQSRYEDIRCYNCNTPGHKMSQCKRLANGLPKDDYTVERKDISETSKTVCTVAAPSNTAFRPAVVMLPINGMPTQCLIDSGSAISMMYADYGIYYAAYGCDLKIKGATGVEETIKSYSKLDVNVGTKDIMVNLHHSKSSALLDKMILGMDFISQVSPTTITAEGIVLNNQLFKFVEDIGSTTSAPVDIARETVPVRSLSPKFQINNTNIVPVATLLLSNVDAFSRSTDTHDDEGFVNTSLMDKTCYGQCGENVPSTASEISKVMPSLSVNCSIRLMDHAETTILETIDAVTSEEAPAILLHGQIPIDKCDIATFSTTDVIKIAELSVWTTELSFLDTAWKYLFDSCKYLTDTVCRRHGDFEDVDPPPDALPISRGGEENPRDLLFKGLLNVKMKIKLKFLGTFQCFYGFLLFCEAFSGRMSDKHRSCRYLTFDAHWLYVFYSLIKDEIPMVKSLFLNICHCFIVSLLFLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0R2</accession>
    <name>A0A0N5C0R2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0R2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0R2"/>
    <dbReference type="WBParaSite" id="SPAL_0001159000.1">
        <property type="protein sequence ID" value="SPAL_0001159000.1"/>
        <property type="gene ID" value="SPAL_0001159000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001159000.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="46596" checksum="4F07EF834497AFE8" modified="2015-12-09" version="1">MENPSPFTTTSQPTSSSPSISFSKPSFSTPASPAQNVNFSKPPSPVNPVLMKINSRSRILKIKRDETSAVEDEVAHERYMQASQKVSLSFGDIFIDNNSTEVRKRANSCIEPISVLTSVQTLPTNSTSSSSPKTSIEGNSTSLQKQCYSPSTNQIVENNLPYSPSPTPSPTRHRILRSCSPRTLLSRPSSLNGIGQGSTPSTITGLKRKRPDAISVGGSPYTYDSDSESGSSTISLTSSTGIQTTSSSINTAFRGTLFPTKKPKLARNCPSPLTKVSTTPTEGLVITSFNNFPSNELSYQDIMEFENDNASNVATTVNFIEPSSIVRNGNSKIKTGNTDTAKTTNEEGGNISTFMEPIPPVILENIEKQRTLNNDETDTNNTQNKNKITFCDDKEQQSNTKKNINEICKTFDTDGIINTTGDFSFQNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1C7</accession>
    <name>A0A0N5C1C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MULE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C1C7"/>
    <dbReference type="WBParaSite" id="SPAL_0001180300.1">
        <property type="protein sequence ID" value="SPAL_0001180300.1"/>
        <property type="gene ID" value="SPAL_0001180300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="907"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001180300.1"/>
        </source>
    </evidence>
    <sequence length="1283" mass="143183" checksum="61577B28FC341A4B" modified="2015-12-09" version="1">MDNSSISEICSTLQEDGELCSDVLEFIRSRRNVLVDRTNRENIRKSPNGNRSGTFSSSCNNANVASPQNVMPNYAPVSANNENMYGGPQQVGAMNPGVAYQHTSGLPNSYNGSENANVASQQNVMPNYAPVSANNENMYGGPQQVGAMNPGVAYQHTSGLPISYNGSENANVASQQNVMPNYAPVSANNENMYGGPQQVGAMNPGVAYQHTSGLPNSYNGSENANVASQQNVMPNYVPVSANNENMYGGPKQVGAMNPGVAYQHTSGLPNSYNGSENANVASQQNVMPNYAPVSANSENMYGGPPQVVLMNAGDILNSNVLYQNGVSVANLYNTGNVNVASQQGVRSAPVPTLTNNGNLYANSSQVVLMNTSGIFNPNILYQHGTTLLGPINNGNLYAGPPQVAFMNPSGISNPNVFYQNGACVANIYNTRNVNVASQRSVISTFGPTLINNENLFASYSQVGAINHGMNRNTSPLLRSSGLNVANDADLRVDISPQRMRNSNVANDADLRVDISPPRIRPRFRDSNVGNDADQRVSISPPGMRNSNVDNDADLTVDISPPRIRPRFRDSNVGNDADLTVNRGEFEDGIRTDSGSSCSGTHDSLSDGTSSELDEELFNNNQLFRSKQEFVKQFSSVSKKLKLGYVVTEDFITGCDTERSNTAIWLYEPEQTNFFNPSGRMYTLKSGKEITSGGRYCSTYICTGCKSVADARNYRKIYADYPGCSIVGFKGFKKRRGPFSHDPGCSAETLQERIGYSARLKTSKDSAKRPISCKSAFVLNSELVGKICQGMNWGIGVSKTKLGLYSGSIGRTARQRKYLAGPKVDKTTFEFPQELKFVDPIVDGKSHEPFHIYGRTNSHIIVFGSDTLLKIYAKSEVRMGDGTFWITPKGFRQVYTIIVVINEEKRGEKRRKYIPVVFAIMKKKSKELYELLFKIIRKRLQKLELEDIPPVVFLTDKEEAVVRIIDEFYPGTHKLCYFHMCQSFTKKLQTVGLIKMLINVRKKNSDESLKAKKFYSFFRKTICIPFLPKELMKKMWNQLKREVTNNWRNYLCESFVLQQLKSFVAYVDDWFGEEVTDTELNKICKWKQVYRTTNACEAINKLMKNSPYAKKKGTVENNAILLKSFDEQSRLMVYKFDSFRDKEEFAFEPQSKSCIEKERLIRHYQEQLEASNMQNVETYLNKIIKVMMPRSIQETVNYTLNQLEYLETPEQRVENNNEEVEQVVEELAIRTNVSQDQIEDAMLASVLLDVGDNGTETQVVTTRSGRTVRRNSQYFNRDYITRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1V4</accession>
    <name>A0A0N5C1V4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1V4"/>
    <dbReference type="WBParaSite" id="SPAL_0001197400.1">
        <property type="protein sequence ID" value="SPAL_0001197400.1"/>
        <property type="gene ID" value="SPAL_0001197400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001197400.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23306" checksum="B7749335A6B29D30" modified="2015-12-09" version="1">MIFQGVYCKKILKCYYCGVRKKGTQNWISFSNETCKPKVVACTKNHVACVKARVSDHSTQFLITGCSEDKFTGCDQSELTPGGAKLERCQCESNLCNDLKINSSSDFMFFKNIGLDKSDKKFEVHEEGAFIVTEETFNKFDKSLNKYSDHSQRSYAKTPHQKGRGTSDILIVSVRKQWNNQFITKKLLFYVYIVIFLFFKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C342</accession>
    <name>A0A0N5C342_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 130 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C342"/>
    <dbReference type="STRING" id="174720.A0A0N5C342"/>
    <dbReference type="WBParaSite" id="SPAL_0001239700.1">
        <property type="protein sequence ID" value="SPAL_0001239700.1"/>
        <property type="gene ID" value="SPAL_0001239700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001239700.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36223" checksum="A875B28C77FEBA0E" modified="2015-12-09" version="1">MGERKGQNKYYPPDFDYKKHKNLNAYHGTTALRDRGKKMSQGIIIIRFEMPYNIWCTGCDSHVGMGVRFNAEKKKVGNYYSTPIYEFDMKCMYCDSHYIIRTDPKNFDYEIISGARRQHLRKNISKNEIEEETEGRNDDISVDKMSKLNHLQNDYVSSKKSTKDVSVLERYNKKMKDDYGANSLARDILRKQKNEIRDVINKEEGLKYSLGLKHISLLPEKEIDKIKADAIVKTQCFVNAYSSTTSLPKNESLIDKLKRKSNDFYDFGSQKKFKEPPKIIQFKKKEVKTIKENDTSTTNSLLVEYSSDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4F2</accession>
    <name>A0A0N5C4F2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4F2"/>
    <dbReference type="STRING" id="174720.A0A0N5C4F2"/>
    <dbReference type="WBParaSite" id="SPAL_0001283300.1">
        <property type="protein sequence ID" value="SPAL_0001283300.1"/>
        <property type="gene ID" value="SPAL_0001283300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="9">
        <location>
            <begin position="45"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001283300.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60331" checksum="413F3288EB657A7B" modified="2015-12-09" version="1">MSTFTGIISRFQHLFGSPLNALEDSIVGVVNRNSDIIIKFQSNDHPLVSQDDAKVFDKTFRLLDHVFKLCQKPKLKLKPSPPNILEIIPDIYKHLNLILKENPSTYSEILYLRLYMSNLDNKCKGIIKLFKDNKDDIYEEESGTRLSLTKKVLSFSHMYYELIALSPEGKFSPKSFRITKQEASQFWHENFGDSLIVPWNQFENLLKKVHIFSDNTNESNSLKKTMDLTSNSHISQFEFDVFTRLFQPWDKLLDNWRVLAVKHPAYVSFLTYDQVKSKLEKFINKPGSYVFRLSCTRLGHWAIGYVAPDGKIYQTIPNNKSLVKALVDGYREGFYRYPNGEDNNPDLTKELEASTAGKTVHVTQEQFEIYCSIGSTFEMCKICDENDKDIRLEPCGHLICKTCLTSWQEVTTGTKNCPFCRCEIKGIEEIVIRKFSNNIKNIDKNKDGGGDDEIITKNKLHLPIKLSFGKGNKDKQRSYDKTSSDSSPIDGTVNNISSRNLPKIPNLYNNCTAVLTSQTTNVNETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C551</accession>
    <name>A0A0N5C551_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C551"/>
    <dbReference type="STRING" id="174720.A0A0N5C551"/>
    <dbReference type="WBParaSite" id="SPAL_0001308000.1">
        <property type="protein sequence ID" value="SPAL_0001308000.1"/>
        <property type="gene ID" value="SPAL_0001308000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001308000.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47573" checksum="88CAA01A832BE9B5" modified="2015-12-09" version="1">MQAVMTNMGQDNNTTVSNQTSLKEESVVKNFKNNSTCNEMGNKKLVDEDEPLDLSNKNNLISTMNVENVSNDIVVSDTIRLQEQLIQNGALSLLPYAFQSQVLNKSSTSTSSNKWSSPRGAANRRTYTQADLEAAVNDIRSGKLGTRRASVVYGIPRSTLRNKIYKLESTTANPADILIIGKKKKKCSDAEGKDKEDDKSPYKSLTEPEIHLSKLFNTNESVNVANGMIIKSPKNEEGCLPCVGEILGFNNLQRQSSVLSIGLHQKEENEKRILSRENSFNKIYEGNTSRNSSENGDNSNSDGLKKSRPKRGQYRKYDKDALDEAVKSVRRGEMSVHRAGSFFGVPHSTLEYKVKERNLLRIKKRQKSFEDYNVEEKESLLVKEKNNALSKNQQSSNVLTSLVTSWNMLSHNSENMLASKSSINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5A8</accession>
    <name>A0A0N5C5A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5A8"/>
    <dbReference type="WBParaSite" id="SPAL_0001313600.1">
        <property type="protein sequence ID" value="SPAL_0001313600.1"/>
        <property type="gene ID" value="SPAL_0001313600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001313600.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24746" checksum="77E63A1679DB14C8" modified="2015-12-09" version="1">MIWKHAKYIFYNPGYSGLKVFVTGHSLGAVYASLAAFKISYSKYRDGKDIFLYTFGGPRIGSLEFAKNFDKLVPNSYRVVVGTDIIVHFPPCKKMKERNLKFYKKIFRKRKSKPCDPYDYNGYYHHGVEVWYPLGTKSKYFICNGYPKNEDFGCSDGLVYYKRKFLENRRNHSIYFLDLTDKYADIFLYKPNIKCSLRKSPKNRRIQLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5K3</accession>
    <name>A0A0N5C5K3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5K3"/>
    <dbReference type="STRING" id="174720.A0A0N5C5K3"/>
    <dbReference type="WBParaSite" id="SPAL_0001323025.1">
        <property type="protein sequence ID" value="SPAL_0001323025.1"/>
        <property type="gene ID" value="SPAL_0001323025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001323025.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10807" checksum="148C82DB8314D2F3" modified="2015-12-09" version="1">MYEIVCVKKMRPEFSLDWFNNDNYTLNTLANLIKECWFENPSSRHTALKIKKDLLKLIEIYDTEALKKKSCHNINSPFTSQTYFEPLNQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5M1</accession>
    <name>A0A0N5C5M1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PL48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5M1"/>
    <dbReference type="STRING" id="174720.A0A0N5C5M1"/>
    <dbReference type="WBParaSite" id="SPAL_0001324800.1">
        <property type="protein sequence ID" value="SPAL_0001324800.1"/>
        <property type="gene ID" value="SPAL_0001324800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031780">
        <property type="entry name" value="FAM65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026136">
        <property type="entry name" value="RIPOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829:SF13">
        <property type="entry name" value="FAM65 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829">
        <property type="entry name" value="PROTEIN KINASE PKN/PRK1, EFFECTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15903">
        <property type="entry name" value="PL48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM65 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001324800.1"/>
        </source>
    </evidence>
    <sequence length="870" mass="98065" checksum="A9377E5AB4A8AC10" modified="2015-12-09" version="1">MGRLQLEIKGILGFARLTTGDTFEISFKHGNQKIKSRGKTLPDKTQIWDTTTVMLECLPTHPIDVKVQEVKFFKSKTLSERSFDPSNFFTTTSQLVTMNLNSSGTIKLQFIITWIPLLASKAIINQASIPSSNLVRSATQLSSMPYSPTITVKNSTSFCGGHSLGRIKSSLGNDITPEKGKPRIVLRDKKRNKSKGDAQKEQWRASTTLLDAAYNNLSKSIPTLDSLSALKELSRSRNNIDEDHLFHLEEEEVLPSIDENQRTSKFFSAKFLGNKKQKQWNRSLSMHQLSVPDSSTISRNSGTPSPKATSDQGNGNERHPTETIMQFNSKDINESFFTSTTSNSSGIGSEVSNNSEQGLKIIDELLGIMDSLRDRISSLRKSELVEINAFEAGMLSWESVLKFNRANLIEDRKYGKLSKGRESNNGNKRGSIYGGVHNKDYDHHQQAQYDELDDNVLVDSFHNSPIPKNNGGSVKNGNHCMMNRSYYNNYSPVASEKQYNHGTLNGSCGPSQRRFKQFRDRRKSLGVVFDQMSISDISNGGTVRAWNHGGDILSVSDYSFDLYKSATSNTQLDDCLRHHLTNSLNIIQKLTELVNKSPFEYKINQLLSNLDNATSALEEMMLINDNLPNIPNISNMLSELGVECDIQELWLGICYTLSSFLIVPTKELTIKLYEYVSPIVSYRYPDLVHQVVSRFIKIMCDESYWNPTSVSLYQFISSLRGKKIKTYFENLAHEAWISKKLSSNDSNEIAEIMYRLKNIPMVPPIESLRSIALVLLSENEDCIQPVCLYLVNSNVELTEDLTSCFLSLLEDDDERTRIASCRVLSILKPRNVLKELEYIMNFDPSEVVRCNAKHALTSIGFNTTNEPVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C641</accession>
    <name>A0A0N5C641_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small integral membrane protein 19</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C641"/>
    <dbReference type="WBParaSite" id="SPAL_0001341600.2">
        <property type="protein sequence ID" value="SPAL_0001341600.2"/>
        <property type="gene ID" value="SPAL_0001341600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001341600.2"/>
        </source>
    </evidence>
    <sequence length="78" mass="9357" checksum="092393C9F3EBB9D8" modified="2015-12-09" version="1">MIFAIPKINITNNEHIIITLLFFIIFGLIGYIVSQYYQRRYKKRTYLIQPSIVKKHIPGDYQLFSIESVDDKYEAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6D3</accession>
    <name>A0A0N5C6D3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CXXC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6D3"/>
    <dbReference type="STRING" id="174720.A0A0N5C6D3"/>
    <dbReference type="WBParaSite" id="SPAL_0001350300.1">
        <property type="protein sequence ID" value="SPAL_0001350300.1"/>
        <property type="gene ID" value="SPAL_0001350300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="6">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="6">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001350300.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64078" checksum="2A80057CFF406F82" modified="2015-12-09" version="1">MSNIMTTSNQINSFNSIPSNNNTDIIPQSNTGSGNRGNGRINNSPNNNINCMEKSNPSSRTSSNPSPISSSLSGNINHCYSSLQQQSHTLQPPQSSGGSNGYHQMSMSTYPPSNNYSHLSPPHPQISMIQYHGLQNNSHIGVSSNYRPIPTTNSSSTGNNNGNNISGNSSTTSTTTSTTTTATPTAMNRSQRCGICRGCQCKPCGHCTYCQDSPQFGGPGVKKQSCIERRCLRVLENRLQRDSPSFKARLGCNNCDDCRLADCQVCLVCLDKRFFDNKYMTGALCAKKRCNNATSIELPCQIGNNSQERNLKRNLDHNSNGYEGNGKRRSNGNINNNNNYTTNQQMPLNYQQPHPQSGMNLMMGVNGMQQLPPTTIPSTATNPVQPPTIQSDPTTPATHHQNTKHNTSQPTTYPLAVHDENISKKGNHIPLTQQYPYQQIPQQSYHETNYPSQMAQIPYSIVHPSKYHTYQASNNMYHHHNNNTTIHYPHSNYQGTTTGNGHSYQLSGNGPTHTPTTTQAPMNGSPINGSLSSSSTSSYNNANFYDYDASFYQGTFHPSTSADPYLPPSYTPELKNNVVIQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6D5</accession>
    <name>A0A0N5C6D5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6D5"/>
    <dbReference type="WBParaSite" id="SPAL_0001350500.1">
        <property type="protein sequence ID" value="SPAL_0001350500.1"/>
        <property type="gene ID" value="SPAL_0001350500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001350500.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18370" checksum="6E3641A78904DDE7" modified="2015-12-09" version="1">MNQDKTKRVDKTKDKTTPTTKRHTKEKKVNSVNSTNQDKHVKKKEKKKEKKEDVENHNKNSKEVPKKKCDKPTMRSNPSQIQDQPGYQCLYMAPTPQCNKAANISQEANNFERKFDYGKPTTPMAGNKPPPPQQPQTVLQTQVVQGKDDLYENLSVFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6T3</accession>
    <name>A0A0N5C6T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6T3"/>
    <dbReference type="STRING" id="174720.A0A0N5C6T3"/>
    <dbReference type="WBParaSite" id="SPAL_0001364800.1">
        <property type="protein sequence ID" value="SPAL_0001364800.1"/>
        <property type="gene ID" value="SPAL_0001364800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001364800.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="8221" checksum="A68BDB864D5E22EB" modified="2015-12-09" version="1">MLSKRELRVNFLHEFKLRRNRVEAYRNIVNANGEGSTSERFLRRWFEKFQRVKFDLNNEEARLEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Y2</accession>
    <name>A0A0N5C7Y2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL24m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L24, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Y2"/>
    <dbReference type="STRING" id="174720.A0A0N5C7Y2"/>
    <dbReference type="WBParaSite" id="SPAL_0001404200.1">
        <property type="protein sequence ID" value="SPAL_0001404200.1"/>
        <property type="gene ID" value="SPAL_0001404200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001404200.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32660" checksum="3B7C1F03C7FA40FD" modified="2015-12-09" version="1">MFRTVALRCVKKPSSTLGFAKHMPEDYVERMKRTVPKKIYSNRLGAPDIIRWELPPEDYTPTPKYPWSSEVVQESVDRARKYHESLLQSKFFRLRKSLYNKRLSDDNWFIFKGDWVMVMVGKDKDRTGKVIEVNRDANTVLVGGLHTKLNDQVSGLEKYGIQNTKAWKEQPLDVSKNEVMLINPYDDSPTFAEWKLNEEGTEYVRVSTSTGHAIPLPAEAFITYEYNEKKSYLENFKDTKADVVLKRTYMPKLCTFEDEIMESLGIRDERRRKPTFWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7Z6</accession>
    <name>A0A0N5C7Z6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7Z6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0001405600.1">
        <property type="protein sequence ID" value="SPAL_0001405600.1"/>
        <property type="gene ID" value="SPAL_0001405600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001405600.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36190" checksum="BD338D13740505A3" modified="2015-12-09" version="1">MSDQDESISISLGLGVGSTISSTTDQYLIQKVLGEGGFGTVFSVTPASNSSISYALKVEKKVPERKEPKLKMEINILENLQKRKINQRFTNIYDKGKTKTFYFIVMELVGKSLADIKDTRPHRILSPGCGIRVSIQCLESIEALHSVEYLHRDLKPANFCIGTQGKKRNIYMLDFGMARKFTNSKGELKTPRKIVNFKGTLKFAPLRLHEGNEYSRKDDAESWFYMVNDLIMPKGLPWRLESDLDGVRVLKEKFRNDIDLEVYYKSTKCKGEFIQLLRLIDQIQFTQAVNFKAFTKIMEAAANCYNYGPNDPYDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8C6</accession>
    <name>A0A0N5C8C6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8C6"/>
    <dbReference type="STRING" id="174720.A0A0N5C8C6"/>
    <dbReference type="WBParaSite" id="SPAL_0001417700.1">
        <property type="protein sequence ID" value="SPAL_0001417700.1"/>
        <property type="gene ID" value="SPAL_0001417700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042505">
        <property type="entry name" value="DYNC2I1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022">
        <property type="entry name" value="WD REPEAT DOMAIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001417700.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="88702" checksum="4219C71A1614635E" modified="2015-12-09" version="1">MEDFVKDNEKHSEEKRKRSRSKKDKYKKDENKIRTKHKKKTEYENDFEEDEKDNNKNKKDINNSEYIKNNYEDDFEEDSEENEEKLAEQVKSSQILQRLTSHKAPSLMIQKEETNERPTTRNIRRIPQMLNTNNQPITPSPTSRIINFDNVRTIDLESISSSASRYRKFKNLIGMESVIIVFDEIPPVKDYEFYMSMFGSKTKSQIGCQTGDDNKNINIMTEGLYNKENFWCQFPEFNQISNFGREGEGITDEEIKKKEDLDEELLEIFSKNRLKDKKLISLANYMGKIISKITELNETNNKQKDDNIFLDHKSDFIFTYGYNELDSQFYSENASVTALHYSTFSIPSTKSKSLFVAVKMEICKIDPKFNNKTFIIEYSGSNYQNVINVFCATSEATSLCTSPNNDMVLVAGTVSGTILLFDLYENEKFFKSYKINFENNIQKYPIRMACFDTSHESLDNEFTEINSPIISIHGFSSKLDTDSFSLISLNENGILTLWSIYKVSKQSIEIETNLGLLRPSSTIRMKKREILHPLKTIPSTVYSPTHVIANVMEIITPNKNISEIINESQTDKKIVEERINILIATGNGCVLNTTASTLGIKKKSTLCKGLRLLTLINENTFEITSIKSSPFSEHIFAVGLCTGNLVIGSIHENNKKIILSPPEHLKLTVTSVEWSPFENGVIYSIHNYNHILIWNINISIHPIITTNLNDSIGGSNIKIWTTKCFIGNDNYAYLLFGLTNGKVQIHRLENILKNDDQKQNKNLDKIINVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8G1</accession>
    <name>A0A0N5C8G1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8G1"/>
    <dbReference type="STRING" id="174720.A0A0N5C8G1"/>
    <dbReference type="WBParaSite" id="SPAL_0001420800.1">
        <property type="protein sequence ID" value="SPAL_0001420800.1"/>
        <property type="gene ID" value="SPAL_0001420800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23801">
        <property type="entry name" value="UBCc_UBE2L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000011">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001420800.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17956" checksum="B8B7DA3435B9980C" modified="2015-12-09" version="1">MSSSHRRLVKEINDIKNSGNAGFVNLEFNESNLLHWEGLLIPDREPYNKGAFKISIDFPPEYPFKPPKVLFLTKIYHPNVDEKGQVCLPIIAPENWKPATKTEQVINALLGLIVEPEPDHPLRAEIAEIFINDRKTFNKKADEYTKKHAEKIPENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9I5</accession>
    <name>A0A0N5C9I5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-coenzyme A transporter 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9I5"/>
    <dbReference type="STRING" id="174720.A0A0N5C9I5"/>
    <dbReference type="WBParaSite" id="SPAL_0001456800.1">
        <property type="protein sequence ID" value="SPAL_0001456800.1"/>
        <property type="gene ID" value="SPAL_0001456800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001456800.1"/>
        </source>
    </evidence>
    <sequence length="755" mass="85471" checksum="41E24695046E460A" modified="2015-12-09" version="1">MDTTKEDTLKNERLHSDNFDNEKATNSPSNTWKNSIKSGSVNLNDNNDQMSDVCSNLPSRLPSIALKDKTTNNSQISLHDGNCNNNTLSRNSLPNHNNDMINTENNHHLKCNVKDLKINEMSLDVPSTNSNMSSPLLPQEEKKNLCRQLSMSEDFFLKRVRRKDANDEESLLSHHSSLRRPRTIEGIMAFESTPDSPSVAANTPFIIPSFYDSNSDQEELEQGSSCLSRFCANIRGDESSLALLLVLYFLQGIPLGIIGCIPFMLSERNVSFTDQSFFSFSSYPFSAKLLWAPIVDSFYFKRIGRRKTWLIPVQFFISVYLLVLSFYISDLIPEDHTKSMTISIKVLTLLFLPLNFLAATQDIAVDGWALTMLSRKNVGYASTCNVIGQHAGLFLGNNVFMFLSSEKYANRFFRSANGSGGLINFAEFLLFWGAIFFITTTLVLFFKKEVDHSKDDSEVEHKKHDVSLESNNIKNNNLTTIAVKEDEEEIELGVGETYLMLFKIILLKPMLLLLFVLFTNKLSFAATYSTTFLKLVDAGVKKEDISMLNVFLSPLSFILPIFVGKFTVGDYPLNLLLYAYPFRLCMNFVYGGLLYATPWFKTETGEFPYYFYGIWLVAMLIHDSLSITMFVSIMAFFAKISDPKIGGTYMTMLNTISNLGGMISSTWVMFVIDLLTVKNCYVPGTKENLGTCKKSELKKSCLAAGNSCEYEVDGYYLTVGIATIYGIIWIIALWNRIKRFQKIPRGEWLVFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAH4</accession>
    <name>A0A0N5CAH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAH4"/>
    <dbReference type="STRING" id="174720.A0A0N5CAH4"/>
    <dbReference type="WBParaSite" id="SPAL_0001489700.1">
        <property type="protein sequence ID" value="SPAL_0001489700.1"/>
        <property type="gene ID" value="SPAL_0001489700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="198"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001489700.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="58465" checksum="E4B2993EFE839696" modified="2015-12-09" version="1">MHREWSRGSAAPGSVKPIYGAQYPPLHSQYSPKNKSTKNEEPISGSKNEINFRRYQNSTSDVWETDLSDDTKNTPTLSQIDVLSNTMPITLNRNDVLMPNCHPQRIKNAKTQAMQRLATQKDPLPGTNNIPTATGPLYPRLPSISSSNDNSLLKNVDQVRFNRLCSMFGVKMNGEVDPTIKPAENIDIEQLQKDCWMGIPHKLRPHAWRILSRYVPTRLDRREMTLKKQREEYWHFVEQYFYTRFDDQHQVTFRQIHIDIPRMCPLIPLFQQKQVQEIFERILYIWAIRHPASGYVQGINDLVTPFFVVFLSEFIPDDIEVSTFEISKLTKQQVEIIEADSFWCVTYLLETIQDNYTSDQPGIQRKILDLKDLLIKVDNNLHCHLEGNQVQYLQFSFRWMNNLLMREIPLRATIRLWDTYLSERNGFSHFHTYVCAAFLRLWSKELQKEKDFQGIMLLLQNLPTSCWGDQQIRELTADAYSLMSVFHGAKKHLTSSSSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB80</accession>
    <name>A0A0N5CB80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB80"/>
    <dbReference type="STRING" id="174720.A0A0N5CB80"/>
    <dbReference type="WBParaSite" id="SPAL_0001514300.1">
        <property type="protein sequence ID" value="SPAL_0001514300.1"/>
        <property type="gene ID" value="SPAL_0001514300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001514300.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17509" checksum="3775EB728ABC0ACA" modified="2015-12-09" version="1">MYFIGALEEGFSEVVKENSVVIKSGNKAKSAGFLAKYRDSILTKNSKVSDSDIKTLIADLMPIFEFINEKYVFYNFYARYYAKCLINNKSVGEEYKIGFINHLKHHCGFGFSTKLINMNGDVVASKDITRNFCKHLVYQPFKTSLWIWFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBH9</accession>
    <name>A0A0N5CBH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CBH9"/>
    <dbReference type="WBParaSite" id="SPAL_0001524500.1">
        <property type="protein sequence ID" value="SPAL_0001524500.1"/>
        <property type="gene ID" value="SPAL_0001524500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="473"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001524500.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="73804" checksum="39C966A37BAE397D" modified="2015-12-09" version="1">MPKRDEVTIPLQEHNPQLTVTSFSGVLSNFADIALGTTHSQGIEFFHAVEEGLSDQLVGLHKGHCLSLKNSSGETLLIVGSRCGHINLVKKLVEDSDVDETDNEGWSALLNAAQNGFTDICDILLQNGASVDLSDLMGWTPLMWAVYNNHPETVKLLLEYKAHPNVVDEEDGLTPLILAAGRGYEEIVDVLLKNGGSTNACDKFGSTPLIWASRKGFLGIVELLLTYGCELDAVGMYGSTALMLATKGNYVQVVEKLLAHDPNVNVCDLNGQSALATAAREGYADIVELLIQSGAFVNLVDRYGNSILASAVRSGNINIVRLLLDKYADVNAKDSENRTPLHLAIDKSYVDMVALILEKKPNLEVKNNEGETPLFRAVKTRHVAITQLLINAGAKVSCCDNYNDNPLHLAIKARSQRLTKLLLSNPSDSRLLYRPNKLGETPYSLDQSNPAPVLPLIFGQIDGSVEANTMLGYDIYSDVLADILCDPVQNLPMTVGFFAKWGSGKSLLLPKMRDSMKYFARNWLESVELTLSYVFIISSAIFTAILCIIATTFASITGSQKVVNITAICIITVYLIVLLSYLLLYYCTKKTYWKSIKYLQKSVAKFLRKLKLVVEVLSLNSPERSHKELIASPVCFLFADDHKLSSVGGHQSFTVILKTLYEAIEDXXXXTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBR3</accession>
    <name>A0A0N5CBR3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBR3"/>
    <dbReference type="WBParaSite" id="SPAL_0001532700.1">
        <property type="protein sequence ID" value="SPAL_0001532700.1"/>
        <property type="gene ID" value="SPAL_0001532700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001532700.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="99534" checksum="284962A9E279AABD" modified="2015-12-09" version="1">MADNGINPNVTREELKEVLRLSDGMWQQLCVDSGLDCIPSSNDSVGQRKRKLSELNEESVDVRKKPLLSKGSSFTSTQHIDDSSMEVSDSTALTKDSSVAGSVNILQDSDFMALAATANTTSNSTSNSRNGTVTMDVFETTNASSQPPSLNIQNDSTFMALADKTSSTNLSKNKDFTLDSDITDTGEHPPLKDVTASSTVINSSAASRDFSIGMDVKQKDASQDFRRGRNRSKTTGEEVLNVTTSESVVISHSKRTKFSLGKRPKLDSIEEDPPLDSQDGGDEISSSTLHESLAVSNKNLTDDSALEPSSRQTEMQSIHLLQDEDFLDLAGISGSEQKSMWRGRRFNGSTSTVSSVGKNNDSQDFRRGHDRSKTTGEEVSDVNTSESTIISHSKRTRFNLRKRPCLDAIEEDSLLESKRDDDEIASVTLEESVIVSSKNAVNDSALEPSSRQTEMQSIHLLQDQDFRVLAGMSNSEQKSMWRGRKLNGSTTSSIGKLAEGGDENVKGPSNKVTVPSVDTSNNQNSSGLAETSDIPKKSRWRRKAPNTTGESTTVESDGSSDKLTTSSINSSSFAIPQGPVIPRNNFDITGSVTSESTPFLKRRSLRSVSNNSVDTRVLPKPIKAKKNLDVSSFLNGNPKIAFQEIQQKRKTKIIVNDDTSEKELFKNDSVVGAKTKGHSRSALSSQSLLSSQGDDDEEEKVLRRSERISKRNIVNINDSLFQTATPAIRKPGKKVLNQSKTSNNETTISRSCSPESVMSEGYSEFPLLIDESDANLNGGSKKGAKHAVIRGKKEKQKVLVVRRPRIIKPNEDQIQFTNLRRSRRNRIPPVDTSLLQKPIYERDENGLLTLVGVSEVEVKDPLFVKYGTADFTEINNIRAVQQRAKRQKKLAKEQNLAYYGIKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBR7</accession>
    <name>A0A0N5CBR7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBR7"/>
    <dbReference type="STRING" id="174720.A0A0N5CBR7"/>
    <dbReference type="WBParaSite" id="SPAL_0001533100.1">
        <property type="protein sequence ID" value="SPAL_0001533100.1"/>
        <property type="gene ID" value="SPAL_0001533100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="83"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001533100.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27372" checksum="2AA9E6986B959388" modified="2015-12-09" version="1">MSQRSSSDETSSSSSSGELDTTDSESINNPSKSCCCKKSIRSRSITPLFKSGRRGEESENTIKSKKYRGDTNNYEQKCVKPSKCIGVFGMRRDTTTRTVEKYFEKYGHIESIRIIRDYYSRESKGFCFIKFEKLSNAADALEGMNGKEIEGKFVRVDYAIPKNETTHRGKSRYYDEDEKRYNRRRDDDYHYYKDKYDSMTRRFDRRQKFPNESSSILTRKRRRHSSSSSNSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU1</accession>
    <name>A0A0N5CCU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4283 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU1"/>
    <dbReference type="WBParaSite" id="SPAL_0001569100.1">
        <property type="protein sequence ID" value="SPAL_0001569100.1"/>
        <property type="gene ID" value="SPAL_0001569100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569100.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25891" checksum="3914F006EB103C2E" modified="2015-12-09" version="1">MATAKPSEKEVIQELPPSTDGVENPPGGGKEASDSGKEKEDGSKMPPRDEKSPPGKNMPKGGNGENDKSKSPDVSFPKKGKRRNTDREKSGTKKQPKELFSFEDLVKAMHSGEVQTLLNSYELPGIPHRGIMVKNICVPIVALLSDKEIRKGKIINREIVDLPTGRRHVANVGRIKTYESNVHDNIVTTLTSRTWEMVEFHAFTEGQQPLFKNGNTNLTDIWRFGQWTQIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD62</accession>
    <name>A0A0N5CD62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD62"/>
    <dbReference type="STRING" id="174720.A0A0N5CD62"/>
    <dbReference type="WBParaSite" id="SPAL_0001580800.1">
        <property type="protein sequence ID" value="SPAL_0001580800.1"/>
        <property type="gene ID" value="SPAL_0001580800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF250">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001580800.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62214" checksum="C5FA173997D92ABD" modified="2015-12-09" version="1">MDYSLNFFNILKNTVIKRKTKISFANFLLIILLFFFTKFVPLYTRKLDLYSTSPETSVNFYHINKKSRGLKSRKSLAVSHEKANYITSFKRRRNKREPAIWGEPAGDYSIVVLEDRIIYLHGLLFVDNKISKHYQTNEDMKNGLLLMIQEANEYFYQLNVRIIIVDILETNRSDLSLYTFESYRNSILNRLPKHDFAVLVAHKYAGGLAFVGGLCNERPIMLCGFYSQKPEAMGSIFFHEVGHLVGLPHIETNKTLIVPNCKCKEAKEKGYFKNNNCLKIPGYDHECTVQSMANHFYGAHCINYQKPYVDLSKVQPVCGNGLLEGNEECDCGTTRSCININCNAKSCKRYIKIEHIIGAIVMSILLISIVLVVIVSRTINITKKEKFITKICIGKYQKLIKTFKTNQNVNHSSVLIDKSNTTNYNIKVSRTLSLRPKVPPPPPPLQIPNSTIKNLLIFNKENDFSENSSGTSTTTLEIIDEDQKNTQLKSASNNKALKDDAFETDNNDDTISWKFEDFSSSDEESNDLININQPSNIYLNRYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD79</accession>
    <name>A0A0N5CD79_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD79"/>
    <dbReference type="STRING" id="174720.A0A0N5CD79"/>
    <dbReference type="WBParaSite" id="SPAL_0001582400.1">
        <property type="protein sequence ID" value="SPAL_0001582400.1"/>
        <property type="gene ID" value="SPAL_0001582400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001582400.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="65214" checksum="69E8675B4599F4FB" modified="2015-12-09" version="1">MTSPGKFFVILHENRTVNEFDSIKDATDYLKSLGKNTQARFYPLSTYKKFMTNNSIDWEKYERHINNNVNSTVTRDIPFDRVKTFPTPSMRELSLFNNAIKMKDFEKIKLCIEGNPKYLVNTDTDMPQIIFSGSKTNAIYQAARFNNVEAMNFMLTTLKKDSFWEQLYEKNDMFKLRIDVYWDKLLNSLDKNFEKTPLHYACAFGYKEVVCLLLKYEMTNTSIRNRKEKTAYDIICSQCLEYNEDLANEIRILFKSSYVSMYITPYQTKKPRAVITKGDPFCKLDGNTTNVNLFNEELLIGCAGPIPEELVEKFKESWLKLDSQSLSLGNLIYERRGFMLSRLYNVEYSQYFDFLKEYINVNSHESLRMLDTYFENIYDQTKFVDCMDSVTNDIDKLTSLMEKILKLNSPSSEESSVDSTSLYNIGNSESDEEMEFSTPPSSPKVSTPIFKNYSELVGNHMNRISNEDTFNPEDSLFLSSLTPTKEDMYLYEILKDECKKWKDDEYFYVKLFIASCDHLPAKNIRDLPPIDSPRYKKLLGTKSRGYEKNWNRTVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEH3</accession>
    <name>A0A0N5CEH3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEH3"/>
    <dbReference type="STRING" id="174720.A0A0N5CEH3"/>
    <dbReference type="WBParaSite" id="SPAL_0001626100.1">
        <property type="protein sequence ID" value="SPAL_0001626100.1"/>
        <property type="gene ID" value="SPAL_0001626100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001626100.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24657" checksum="027258A01C0B3A3F" modified="2015-12-09" version="1">MISLANCSAHEIFLFLRIRNIQDLPFNSKVEIVGDLSKEIQIVGKLGFDNLADKPFCQIVVARFCQFMALESTLVFRNYCSDIAERYKEEIEKYTSYLFNDMSYHDTLLEVIKFLGSIIRYRDEVRRYFTCSFGNVYSKPSEAPRPKMMNESQSTQIFNWFKECFAGQKRLQRYYHAGSEYVYGELKPHAFFQLNSKKRSLNENFGAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEK3</accession>
    <name>A0A0N5CEK3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEK3"/>
    <dbReference type="WBParaSite" id="SPAL_0001629100.1">
        <property type="protein sequence ID" value="SPAL_0001629100.1"/>
        <property type="gene ID" value="SPAL_0001629100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001629100.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9235" checksum="550EE4C1B2AB57FC" modified="2015-12-09" version="1">MIIISSHLTYAIFHEPIDFQSKNDMENYNIFKNSNLITSNTLTLDISSIIKKSLMNKFKLELTELFILVLIVFIKKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CES5</accession>
    <name>A0A0N5CES5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CES5"/>
    <dbReference type="STRING" id="174720.A0A0N5CES5"/>
    <dbReference type="WBParaSite" id="SPAL_0001636200.1">
        <property type="protein sequence ID" value="SPAL_0001636200.1"/>
        <property type="gene ID" value="SPAL_0001636200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001636200.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25416" checksum="8DAD13C027B67589" modified="2015-12-09" version="1">MDTHMIKECMPTTETDLKDELNKQESYLQELKIQMAELNGKLKGDERKRRENDIKNVQGNIEAINKQLKLLPTKNNFENNKVVDDQQKSLDIEMNGILNSNEKCSTKHNVFEEKHLIEINSIFQNELAEEKEKIAKLVVDLNNKLQKLQMYAIISSNVKLLTEEEEEYWKMECEKENEKRRILLTEIHSLRDECAMLRASIEQCNLDSKNYLQTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF86</accession>
    <name>A0A0N5CF86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF86"/>
    <dbReference type="WBParaSite" id="SPAL_0001652500.1">
        <property type="protein sequence ID" value="SPAL_0001652500.1"/>
        <property type="gene ID" value="SPAL_0001652500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001652500.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="8236" checksum="EDE1126C4B61BF98" modified="2015-12-09" version="1">MLELELLQQIYFLSPINFYQKYLQNQKHIILQWRKNNGKIYQFKKKDGYSKFKISKYFKDLTIIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFW9</accession>
    <name>A0A0N5CFW9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH OST-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFW9"/>
    <dbReference type="WBParaSite" id="SPAL_0001675000.1">
        <property type="protein sequence ID" value="SPAL_0001675000.1"/>
        <property type="gene ID" value="SPAL_0001675000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001675000.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37880" checksum="EC3D0DB63301ACA5" modified="2015-12-09" version="1">MSVEEAQKIFRYLKSSAIGSKTSLRDLKKNYSDTYGPLSDDFNKLGLSSNDDELIAFLKSNGSVEITKEGRNYYVSFEVFDGEKALKEMIDGNVYKKGKKGFKDRNSEAKSWGNNNYFDDMDNYEASVGPEITALYKSRTLNYYQKLKQKSTAQSPNFHNQQEPKTKFGETYRDEFYDFEKDFNVIDKYYDSLAENGSDIINDNNESKDNISIPSDNNKIPNDNSNIPKDKIDISNPSSNLLNNMKETESNSNKNNHLDSPFNFFPQVNLGSFGEKSLSKTVEYYNKTPKLRKDFRQMISNSLSVINVMERTLEYWEKRIDEKVNVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG69</accession>
    <name>A0A0N5CG69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine-rich protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG69"/>
    <dbReference type="WBParaSite" id="SPAL_0001684800.1">
        <property type="protein sequence ID" value="SPAL_0001684800.1"/>
        <property type="gene ID" value="SPAL_0001684800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001684800.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="24925" checksum="DD80C459C4EBA220" modified="2015-12-09" version="1">MLRVVVGVCVVVDVVVEELEVVGTGVVGACVVVGTVVEGLEVVGTGVVGACVVVGTTVEGLEVVGAGVVEACEVVEELEVVGTGVVEACEVVEELEVVGTGVVEACVVVGIVVEGLEVVGTGVVGACVVVGTVVEGLEVVGTGVVEACVVVSIVVEGLEVVGTRVVGACVIVGTVVEGLEVVGTGVLRACVVVVVFVFAVFVVVGAGFLGGGEGFIFVVVLDEDPVVGLDEGFRVEVIVFTERENFFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CII1</accession>
    <name>A0A0N5CII1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CII1"/>
    <dbReference type="WBParaSite" id="SPAL_0001763600.1">
        <property type="protein sequence ID" value="SPAL_0001763600.1"/>
        <property type="gene ID" value="SPAL_0001763600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001763600.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16407" checksum="8B43E7211BFB33E0" modified="2015-12-09" version="1">MHHVAYLRSVPPTYDFLYSVYEKIVEEEKEIKNEEEGGGRKIEEEKGGIRIEEEGGGIKIEEEEGEINIEVEEEGKENEEKEGEKKSEKERGGKKNEEEEGEEVEKKKSGNEEKNSRGKRNRGRPKKRVYPWLNFHNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CII2</accession>
    <name>A0A0N5CII2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CII2"/>
    <dbReference type="WBParaSite" id="SPAL_0001763700.1">
        <property type="protein sequence ID" value="SPAL_0001763700.1"/>
        <property type="gene ID" value="SPAL_0001763700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001763700.1"/>
        </source>
    </evidence>
    <sequence length="20" mass="2196" checksum="D76DB493D83E9B62" modified="2015-12-09" version="1">MLWVGVLQNIGTESSEMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIK2</accession>
    <name>A0A0N5CIK2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIK2"/>
    <dbReference type="WBParaSite" id="SPAL_0001765700.1">
        <property type="protein sequence ID" value="SPAL_0001765700.1"/>
        <property type="gene ID" value="SPAL_0001765700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001765700.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8685" checksum="B0889ED4EDA61453" modified="2015-12-09" version="1">MTYDFTITIASINFIYTDLIKIEFEHATLISDCVGNDILSFFIELLPASLVNILLDDFIVLDSTQPCLSEDICSFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIW5</accession>
    <name>A0A0N5CIW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIW5"/>
    <dbReference type="WBParaSite" id="SPAL_0001777000.1">
        <property type="protein sequence ID" value="SPAL_0001777000.1"/>
        <property type="gene ID" value="SPAL_0001777000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001777000.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10998" checksum="514D9588BCE74971" modified="2015-12-09" version="1">MRILWRTVKERKPLTPTYRTFLRACYDIIITNVNSISGSLPSQPSTPPIACLLEASFNHIESNNTKQYSSKNEEPISFGLVEEPIFSELIEPIFPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B287</accession>
    <name>A0A0N5B287_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B287"/>
    <dbReference type="STRING" id="174720.A0A0N5B287"/>
    <dbReference type="WBParaSite" id="SPAL_0000018900.1">
        <property type="protein sequence ID" value="SPAL_0000018900.1"/>
        <property type="gene ID" value="SPAL_0000018900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="60"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000018900.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19297" checksum="415505F9D020AF87" modified="2015-12-09" version="1">MTDRWMTPFTARDPLSMCPLGYGGLGLNNRGGLFDDINRLERRMMNDLRMAERQVNNVLNEVGELDDALPEVVNNDKEFKVKMDVSHYGPEELKVTVKDNYLQVEGNHEEKNDKYGTIKRSFVRKFALPKGLTEENVKSELTKDGFLTVGGNKLALEDNVKTVPIEYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2A6</accession>
    <name>A0A0N5B2A6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2A6"/>
    <dbReference type="STRING" id="174720.A0A0N5B2A6"/>
    <dbReference type="WBParaSite" id="SPAL_0000020800.1">
        <property type="protein sequence ID" value="SPAL_0000020800.1"/>
        <property type="gene ID" value="SPAL_0000020800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="8">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000020800.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37648" checksum="394C50C4BE983356" modified="2015-12-09" version="1">MGKVNKKLNVAKKPKTRKGKQVLLNRAPKIIENDKNCLFVKGGRTSETVNNIMQELYLLKKPLATQMKRHNPFHPFENEAGLTEFSQKFDASLFVFGSSTKKRPTCLTLGRMFDHNLLDMVEFNVTNYTPSSEFDAPRPTLGTKPCIILQGTEFENDETMSRVGNLFVDLFKGPSISQVRLQGLETVIQITSAGKKILFRVYKTILLKSGTKTPRVELLEVGPRLDFELSRDKLASNSLWKEALKVPKELTVKPKKNTETDVFGTKLARVHVGKQHIDKLQTRKLKALKKPKIQGGVQKRTPNRGPKAKEGVQKRSVKSKSAIPKRSANRQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2C7</accession>
    <name>A0A0N5B2C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRE_C2HC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2C7"/>
    <dbReference type="WBParaSite" id="SPAL_0000023400.1">
        <property type="protein sequence ID" value="SPAL_0000023400.1"/>
        <property type="gene ID" value="SPAL_0000023400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
        <property type="entry name" value="CCD_aECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435">
        <property type="entry name" value="PROTEIN CBG14344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435:SF5">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23626">
        <property type="entry name" value="CCD_aECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="aECM cysteine-cradle" evidence="2">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000023400.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34314" checksum="7B872D18E5190B7E" modified="2015-12-09" version="1">MSEKHLKIDNIKPLSNGSKRKVKKVKCYEMYIFYDSDGEVIEEDVIRELTPKVVKKKHFNQKWNRTSKNSLSLSKTPKNKETNSTRTKKINLMRTLLSKNRTITRITPFSLSRNSDVRRSPIKHTFYGPSNQIHIGDFYSSRKSKEYSRKNDPVKIIHNNKRSDVFKHGYSKYPKTYIKTQLDESDSKENLKDEKKKYLKGEFEFVPLSAIPYNSDDKQLSITPSTTSNQKASKINILSQETCIKIQTFAKGFNITDIQNWVHNNCFLVKMYIPNVTCSEINVLIDSCYDKKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2G5</accession>
    <name>A0A0N5B2G5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2G5"/>
    <dbReference type="WBParaSite" id="SPAL_0000027200.1">
        <property type="protein sequence ID" value="SPAL_0000027200.1"/>
        <property type="gene ID" value="SPAL_0000027200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF8">
        <property type="entry name" value="PROTEIN CBG16685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000027200.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38991" checksum="018164ED3E08080E" modified="2015-12-09" version="1">MVKSLEMIVKPKTRQEEKKLKNGFEEDDNEDIAYLNLRLIIPVLITYILSGTCVVLSIYLGIREDIYDSTPKNNPKGDIHLLKYGSLKYICKENNPPKANEVPSFLRLVELKSQTNMWLRYAVITPWMIRFFITYCSKRLMDDHKLVKENAFVSMLNSILPYLIFFEILFCSLFSIITVRHDFGDVMHISLHMFVYLAIIYMIIHFCLCTLTLPKDFYPIDIISLAIKFISGSLFCYFGNTVLNYHLTFMIELGCHPYVPYEIAVSEYIAIGGYVLYHFSHVTEIRNIRFICFPRTSSGECEPICSENFSKGGKYEYCRSFELRQRQIQKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2H1</accession>
    <name>A0A0N5B2H1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2H1"/>
    <dbReference type="STRING" id="174720.A0A0N5B2H1"/>
    <dbReference type="WBParaSite" id="SPAL_0000027800.1">
        <property type="protein sequence ID" value="SPAL_0000027800.1"/>
        <property type="gene ID" value="SPAL_0000027800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000027800.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15405" checksum="AE889345581F17AD" modified="2015-12-09" version="1">MSKLIRLNSSVSKLIRLNSSMMSKLIRLNSSTESFALSCQRRKLDRAKESLSVVGSSVLSGITLTKFGGILVLAFAHSQIFKVFYFRMFLGIVIIRAAHGLIFLPILLSFVGLPLNCRRVLTKINNYNNSYIQDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2T3</accession>
    <name>A0A0N5B2T3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1985 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2T3"/>
    <dbReference type="STRING" id="174720.A0A0N5B2T3"/>
    <dbReference type="WBParaSite" id="SPAL_0000038600.1">
        <property type="protein sequence ID" value="SPAL_0000038600.1"/>
        <property type="gene ID" value="SPAL_0000038600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000038600.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13128" checksum="E54F606904B3AF4E" modified="2015-12-09" version="1">MGNTMMFGKFAMYQVEHIETFKKLKGFRPLKNVIFTLIPWEDDGLSWLEVNKEYLLSGLVRYGFFIMSKCSQMNFNIESCKRSPPHEWVEVPTNQKEMLNNGTYSKCTKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3N9</accession>
    <name>A0A0N5B3N9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3N9"/>
    <dbReference type="WBParaSite" id="SPAL_0000069200.1">
        <property type="protein sequence ID" value="SPAL_0000069200.1"/>
        <property type="gene ID" value="SPAL_0000069200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000069200.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14416" checksum="5989AEC742321B54" modified="2015-12-09" version="1">MVYFDLLWGIRSGKNSTNITASSNNDKFKLKKVKCNNVQSEDTIEPNINRIVAAQTSLNFEVQQNERDRLSSVIQTQIPWVEQTGISRILAKFCCTKSYRQQKIQQRQLAKRIFSTQFPPIKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Q9</accession>
    <name>A0A0N5B3Q9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3Q9"/>
    <dbReference type="WBParaSite" id="SPAL_0000071200.1">
        <property type="protein sequence ID" value="SPAL_0000071200.1"/>
        <property type="gene ID" value="SPAL_0000071200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="12">
        <location>
            <begin position="295"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="451"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000071200.1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="161036" checksum="7B792B99FB147533" modified="2015-12-09" version="1">MGDNAARKKRFLEADKVSYESTTKEKEQFESDKPELKRYSFLSPTLSRDKDLLNMSPEDPTNKVMETDSFEKKVDKTVVTLSKTEEPKVVIKALNKNEFEKELLRRNEPIKKTVIPNPSVVKPKDDKKKQKNNDNDMYKLSPDDKKVIVKRSHKVDDSLVKVVTVGKDESQKKDETESADDLKCTEDIMEHDDIENMDEATDEIFSNGDENPNTPDENQYDGDEEPFTPPFDEPNFSNSPIDAAMGGNSDFDDSYGPRTPDSDSNNNDDYPASSSETETLPDSVDDEEYERFCPENVIYISIKGVSEIATMQADQQKLSEIVYIRGLPWRILLLPRDIRVNSGDRTVFRRSLGFFLQCLGDNVCTAWSCLAMADLRIMSQIPGGTDYNRNVTHNFHAEANDWGFSQYITLELLLDPKIGYCYNDTILMKCHVFAEVPHNIGWDSKRRTGFIGLKNQGTTCYMNSLLQAYFFIDEFRRSIYKIPLAEPSHSETSVTLAMQRVFYELQKNDQAVSTEKLTKSFGWDPSDTLHQQDVQEFARVLLDNLELKMKNTSVADAIPNLFKGTLKSYVRCTNVDYESCRYETVYDVQLNIKNCKNVIECFENYVEAEPLDGANKYDAGEHGFQDAVKGLIFLDLPKVLYLHLMRFRYEPQAETYMKVNDRCDYPAVLDLNKYVERQEGDKTNYKYHLHGVLVHSGDFSGGHYVAYINTGLYDGEQRWHQFNDETVSECCHREVFLGNFGGDASEKVGKPYSGAYMLAYIREDSISEVLNPVNDEDIPKELKERFLVEEKEEEARRKDKVTSYLYQSFRIMCPKNLFKYTALDLMNATSQEEFEEIKLQKNMTLSQFHDFLSRLYEIPENKFRIWQLRLTKLKRDGVEAQLGSYRPMQLLGKYDEKFQPNSIEIGALGDDNIVFLEYYKRKDNGKIYYDELPAFSSTNELLFFIKVLHIDEQTEAVTVSVKDIMILSLNKPLSAYMKEFCKICNCSDPYGVRIYEEISPDQIKLIRDKRVPIKEILNLIDGGILILEQTKYDPKIGTVLEWHEKVYNDCVIRCIPVAHMVYKNLNHTSFFTDEEQPEILMAMSMKCSLAQVAEELSNQLSIEAENVYFYNSDLLSLKTPQFSLPKTSFNNITLESLWKSCHNEPHDPRYNLRPYYLHFSLFPFDISELSKLRLTMKVQVLVKKQKIEERFIFPKPNQKVKEVLEEFKEEFKIGGGNENINLRMLLVGSDSRSNRVYHSYKSQTLIQEVYDKTKASSLYIARIEEVPSDQTNVDEASEYLMPVSFFDKDPLKLYGVPFFFKITNGESYAMVRERIRVYLGSSKKDFDKAKFAYLQSGKIVKVINTTTASTANLAELKQHNVGQNRVLPFFLGIDLPNKIHQPKQSSEKSIVIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4N9</accession>
    <name>A0A0N5B4N9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NFACT-R_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4N9"/>
    <dbReference type="STRING" id="174720.A0A0N5B4N9"/>
    <dbReference type="WBParaSite" id="SPAL_0000104000.1">
        <property type="protein sequence ID" value="SPAL_0000104000.1"/>
        <property type="gene ID" value="SPAL_0000104000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041120">
        <property type="entry name" value="RqcH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="9">
        <location>
            <begin position="563"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="10">
        <location>
            <begin position="893"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="820"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000104000.1"/>
        </source>
    </evidence>
    <sequence length="995" mass="114259" checksum="C083BB135F23EBFB" modified="2015-12-09" version="1">MGIEEKIKEIEKEISRTQKNKATENHLGMLRSKLVRLQKMLAQEKANAPVVSVEPKNEEEDVKPKDIQVNITGVKNRFSSLDILAIIHDLKTLKGMRVVNVYDIDSKTYLIKLHKPDGKAVILFESGIRIHKTIYDWPKQMFPSSFSMKFRKHIRQKRLEDVRQIGMDRVVDLRFGDEDRACHVIIELYDRGNVLLTDHNYTILNILRPRTDKDHDVRFTVRERYPLELAQYDKRIPDVKDILEALSKAKKGQQAKRILSPLTNFGPALIDHSLILQGYPPNSQVGVHVQPTEEEANKIHNAIMVALKEFDHIKDTPSKGYITYQNVQKIDGSDMEKFIEYHPMKFAQFTGENSKVLIKEYGEFSEAVDEFYSKLDTQKSEKRALQMERDALRKVENVKKDHEERLKNLVMSQATKKEKAERIEVNVELIDQALLVVQSAIANQMSWEDIEEMTRQGQEQGNDVAKAIVGFDLKNNKIIMRLPDPFDPNNEPMNIAIDVNLTANQNARAYYIDKKLAAAKETKTIQASEKAIKSAHVKAQQTLSQVKANVEVLRSKKSYWFEKFYWFISSENYLVVGGRDAQQNELIVKRYLRPSDIYVHADLHGASSVVIRNPFNGKDVPPKTLNEAGTMAICYSAAWEAKVISNAWWVRQSQVSRTAPTGEYLPTGSFMIRGKKNYLPTSQLVMGFGVIFRIDEESIERHKDDRKSNLMEIEEEPENTVEDEEFPDVKVNINLNDKKDDNEYVVIQLGPTNQSKKKELTEREKYLKEKKKKEEEAKKAQKEKKKQQVVKGKKKGGKNNKKEDEEWDKLEKKATEIIKEVVALQRHPDSDGTDEEDEDNDSDYSEEIVTVDEIKKMKQEENDKVENNGKPPKEEPQEPEDDTDDEDDDKKDDDLSIINMLIGNPLPEDELLGSLIVVAPYQTLNNYKYRVKLTPGTGKRGKAAKQAIDLFLKEKSASATEKKLIKILQTNEEVARNIPGKVKVSAPQLFANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B506</accession>
    <name>A0A0N5B506_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B506"/>
    <dbReference type="STRING" id="174720.A0A0N5B506"/>
    <dbReference type="WBParaSite" id="SPAL_0000115200.1">
        <property type="protein sequence ID" value="SPAL_0000115200.1"/>
        <property type="gene ID" value="SPAL_0000115200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893903" evidence="1">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="3">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="2">
        <location>
            <begin position="219"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000115200.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39276" checksum="217F0F4E64548B1E" modified="2015-12-09" version="1">MFLKLYWLGAALALMPLPTQPNEVHRQDLFPYITADINNTTFPFKLEVTTNSDMVLVKCPDYYYRHKDSDEIFSHNPDVFVSDSIFSPNANLFAWVPLLRNVSGLTHLKCGIINLRSQGNPYYDLTYNVMWKNGNDDGNFMERKEKTKDISPKHENCDLSAENHTIFASKREGGFLLIKEYENIKNLYVNQMFYYFDKLKNNERIKEPCGIIKIYGYDPKIKLKTHESTSEAPKIGNISKINLDGTNQQNIDVVLDMGGNLNYYQGEKIILKRMRYDVNEEPQVIENSTTSITTNFTINGYEIVELMYNYIGENRNFTISKNYYFGPSEKDLIIKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5I2</accession>
    <name>A0A0N5B5I2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ephrin RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5I2"/>
    <dbReference type="WBParaSite" id="SPAL_0000132400.1">
        <property type="protein sequence ID" value="SPAL_0000132400.1"/>
        <property type="gene ID" value="SPAL_0000132400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000132400.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11891" checksum="A3E4DC7903AA6FCB" modified="2015-12-09" version="1">MFTFILCKEGVNKRLVFDEPNKIYRRWMAPFDIYSIYGERCQSSTDPLPQPKDSHGHSYGQKVSTKIVAEIMCSIAIIVLIFSLPEKDCYSLVKNKRRNTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B624</accession>
    <name>A0A0N5B624_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B624"/>
    <dbReference type="STRING" id="174720.A0A0N5B624"/>
    <dbReference type="WBParaSite" id="SPAL_0000151400.1">
        <property type="protein sequence ID" value="SPAL_0000151400.1"/>
        <property type="gene ID" value="SPAL_0000151400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053352">
        <property type="entry name" value="FMRFamide_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323:SF4">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FRPR-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000151400.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="48151" checksum="5BDD4F061F1DD0E7" modified="2015-12-09" version="1">MDNQYTYMVVLLIIICTGIVGNICSFLVYTRYATSINILLTALSVIDICLLTLATPVFVLPFMHKIFVEDSFQAYVLQYIYPLNCISQTCSVYVMVFITIERWTAISKPLQVRSWCTTKSAKIILIGVIIFATIYNIPRFLEYEIIKDNEGHTTYKRTLRDTVLHPNYMVYYYTLLYLLTHFCIPFAAIIFFNSHVIFIILKQKKARLNFTSQQRKEIKTTVMLIIVTIMFAICNVLTFIMNLWENINPTLFSDPKTLTMAYMFNDLANFLVILNSASTFIIYFLFSEKYRILLFDIFHYGCSKTKGENYYNSTFSRSHSMRHQSSIYGRISSKKSSTSLISANDNFKRLNSINNNKLSVNSQDTPLKNDLSRDQKSTTPIHEAKKKEFPNTRTLSIPNKNQQLYRKISDFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B708</accession>
    <name>A0A0N5B708_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B708"/>
    <dbReference type="WBParaSite" id="SPAL_0000183900.1">
        <property type="protein sequence ID" value="SPAL_0000183900.1"/>
        <property type="gene ID" value="SPAL_0000183900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000183900.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10220" checksum="EBB7B5BC8F4E69C8" modified="2015-12-09" version="1">MFRFLPCCSNFKGDIISTTIIKNKVEPEIDKEKETDNKEKLQEKKEENENKLSESIPGSEAKEIPTKSVRQSGEQEADQVACNQKLAFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8E1</accession>
    <name>A0A0N5B8E1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">methylenetetrahydrofolate reductase (NADPH)</fullName>
            <ecNumber evidence="7">1.5.1.53</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:19819"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.53" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8E1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8E1"/>
    <dbReference type="WBParaSite" id="SPAL_0000231400.1">
        <property type="protein sequence ID" value="SPAL_0000231400.1"/>
        <property type="gene ID" value="SPAL_0000231400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="350"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000231400.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="74765" checksum="2F8A4C911174ED31" modified="2015-12-09" version="1">MAPNLDDSQNNEVKFNLDDDTLGLKRNASSVNSFFDESEVNTYTPLIKRINNQIESGVPFFSLEFFPPKTANGVANFINRLDRFRDGGTFFLDVTWHASSDPANLDKETSSSSIARCVLDYCRIDTMLHMTCTQYTKEQTLSHIKQCKDIGLRNILALKGDLPVDPNTSLDQKQKSKYYALDMIKWIKESYGDYFTIACSGYPLGHPDAESYTSDLKYLKAKVDAGADFIVTQLFFEVETFENFVRDCREIGIKVPILPGIMPIQGYASIKRIAELSKLLIPQSILDDLEAIKHNDEAVLKYGIDRAVKMCSQILDKKIAPSLHMYTMNREGPTREILQKLGLWKQYHIKPLPWKPHGGHHPLRCKEDVRPIFWSARPKSYIFRTREWDDFPNGRWGHSSSPAFNDLKEYYMFYLNVSNKDKELQMYGDKLYSIEDVQKVFINFLKQEENENGVKVTCLPWNEDEKGLSFETNLIKDQLIWANENGFLTINSQPHVNGAPSSDPIVGWGKQGGYVYQRAYLEFFTKKENAQKLVDIIDSRYSERINYHVIDRTGKYERFNYNGTNPIALTFGIFAGSEVAQPTVVDPLSFRVWKDEAFDVFNIWSSIYPPESKCCETLKFLHDNYVLMTLVDNEYVKPTIIYDLLKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8I9</accession>
    <name>A0A0N5B8I9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KxDL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8I9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8I9"/>
    <dbReference type="WBParaSite" id="SPAL_0000236200.1">
        <property type="protein sequence ID" value="SPAL_0000236200.1"/>
        <property type="gene ID" value="SPAL_0000236200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000236200.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29770" checksum="6484D18F1CF89E9A" modified="2015-12-09" version="1">MPDLMETKYAYENDMHLTSDDNILDCEEGYSLDNYVESGLDNSHQLAISSEEKVYMKKMKILKETYCTILASNYSLKNRVYHVKKQINYLRRLKRVLCNYLSGLNDKFQEGYLEIDDNDVECIGLDEIIGNVVKDCKIAAALSNRKRKNAHNELSKKKQDDSVSEMTNDEADHVVNDYVKGNLYNSSSTTKIESKMNFHEGQELIYNNMNVSNIKTEENCEPPEKKMAIDTQNCHNETSDVDSSMDNFNDFLKDEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Q2</accession>
    <name>A0A0N5B9Q2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Q2"/>
    <dbReference type="WBParaSite" id="SPAL_0000276800.1">
        <property type="protein sequence ID" value="SPAL_0000276800.1"/>
        <property type="gene ID" value="SPAL_0000276800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000276800.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10245" checksum="19A3F50F41E913AE" modified="2015-12-09" version="1">MPLISTLYIDTYYYLKFQNGFQSNTFRLFLKYTEMVYLPCCPLSFIFFIEVYRIEFINFFCPNKTLFKKSTNSISTIRITTRSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA08</accession>
    <name>A0A0N5BA08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA08"/>
    <dbReference type="STRING" id="174720.A0A0N5BA08"/>
    <dbReference type="WBParaSite" id="SPAL_0000287700.1">
        <property type="protein sequence ID" value="SPAL_0000287700.1"/>
        <property type="gene ID" value="SPAL_0000287700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="167"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000287700.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="49054" checksum="C0C45EEB32EBD553" modified="2015-12-09" version="1">MTYSAIYFCDRNRKSLVSKIYRETTSSIKTFREYFWKHYNAIENMPFFIAENNCYMFIKTNDIYIIGVTENKDTSNIMLIVTFLYKIKELLVSLLGELTAMNINKNLIYIYELLDEILDFGYPQIAEISVLKSYVMQNGNKTIKQVKVPSSVTNSVSWRMPNICHITNEIGVKLTEKIDLTLNKERSIVEYSIRGFIDIFVQLSGMPRVTFRVCDKFKELLDTKNVSDHRGFHLDNIKFHQCISMTKFEEYKELQCIPPEGKTTIISYQLTPEFSLKPIIEVYCTLLKPGSSRIIYSLSLKSNYRAYRNATSIHVALPISRECFNMKHTNSVGKILHNKESNALIWILKNYPGQKTVQSKIEFSLPTFEIEEKIPRIITLQFALNDVLMSDVSVKSVNISERYDVVAYCQTRTCSGNYIIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB32</accession>
    <name>A0A0N5BB32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB32"/>
    <dbReference type="STRING" id="174720.A0A0N5BB32"/>
    <dbReference type="WBParaSite" id="SPAL_0000324400.1">
        <property type="protein sequence ID" value="SPAL_0000324400.1"/>
        <property type="gene ID" value="SPAL_0000324400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000324400.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16788" checksum="275090084F5D7CD0" modified="2015-12-09" version="1">MASGVKVDSSVKTAYDELHNKHMHSFLIFRISDDDTTIIVEKKGGKGAPYSEFVDSMKDCVGNGKECRYAAVDVEVTVQRQGAEGASKLSKIVFIQFCPDDAPVRRRMLYASSVRALKATLGLESLMQVQASDLSDIDEKAIKHELMSSQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB86</accession>
    <name>A0A0N5BB86_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="WBParaSite" id="SPAL_0000329600.1">
        <property type="protein sequence ID" value="SPAL_0000329600.1"/>
        <property type="gene ID" value="SPAL_0000329600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000329600.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33322" checksum="DBA7D987D66DE180" modified="2015-12-09" version="1">XLAISEAFDVCAIGLYHQWGIKNHITISSGLFWSVYYPLFGLDFPITKVPELYADYGHNGMGFIERLLNIYFHYLGDPFLKAPFIAEQKLFDDKFGKGVVNLKKMVSNAVFHITNTEPLLDFAHPTLAKIVEIGGFSIPKPKALSEEWDKILNLRPHNIIISFGTVAESYSMPDEYKESLLTVFKKMPNVTFIWKYEINDEIGDKINNLIKTKWLPQTDLFGDKRITGFISHGGINSFSEAAYNGIPIIAMEMIGVGKKLSKFDIKIGVGKKLSKFNIKDSNIVENTIKGSIFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC08</accession>
    <name>A0A0N5BC08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC08"/>
    <dbReference type="WBParaSite" id="SPAL_0000355800.1">
        <property type="protein sequence ID" value="SPAL_0000355800.1"/>
        <property type="gene ID" value="SPAL_0000355800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894272" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000355800.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18506" checksum="8A4B5943038D606D" modified="2015-12-09" version="1">MLLSLVSVILLSISSILAYMNGGQQRDEQNYISPYDEDPRIFQENLNFYETYVQTHAYHPDIYDNHGHHHQHHGGAFHGMGHDFHHIPGFVNMGIFAGMNLPPPKSPYELCFRPNYMPIVRSNKHLVNFCARYAKHINRAPVHPKVPLDLDQEGSGMEFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC14</accession>
    <name>A0A0N5BC14_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC14"/>
    <dbReference type="STRING" id="174720.A0A0N5BC14"/>
    <dbReference type="WBParaSite" id="SPAL_0000356400.1">
        <property type="protein sequence ID" value="SPAL_0000356400.1"/>
        <property type="gene ID" value="SPAL_0000356400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000071">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000027">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022248215" evidence="5">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="235"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000356400.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51046" checksum="D15B78DEDE0AA8CD" modified="2015-12-09" version="1">MKFLSTLLILLFTNKTIPYLQSDTSELLNQLLSDYDKRIRPYADDGIPVKIDMTIVLGILIEIRENQQVASFVISHYQKWQDPKLTWDPNEYGNIKQIVIPQSYLWVPKLFIYNSMDTKDMLGENKYDVRVQHTGHVKLNIPQFVTCICRLSIELFPFDTQFCAIALASPLMTTSELKINVTDPPQDTYFSGNAEWLLLSVTVRNLAFTEDGEERPEILYIISLKRRPIYYLTVIVAPTFLISALSILGIFSPGTNDGPRNEKVSLGLGSLLAMTVLLDIVAGAMPKSNSIPLLGYYIIAVIILCALAVAVSMALLALSRHFIQTQELPSAFAYRVLWMVPKRRPVNYWETDHSEEEGKIVLPKYSDLIAIYNQIRHISIAQMRFRKKLEKQQMHSLIEKEWNKLFSRFDYFFLFVFQLLNLVILGLFLRNAYSPIPTVPDDFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCY6</accession>
    <name>A0A0N5BCY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000387900.1">
        <property type="protein sequence ID" value="SPAL_0000387900.1"/>
        <property type="gene ID" value="SPAL_0000387900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053124">
        <property type="entry name" value="Notch_signaling_modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35015:SF1">
        <property type="entry name" value="NOTCH LIGAND OSM-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35015">
        <property type="entry name" value="PROTEIN CBR-OSM-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894181" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000387900.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18208" checksum="A7E0CACA013F5030" modified="2015-12-09" version="1">MNNILYFSFALLLPSLLINGFPNQLINIACAKNPSLSMCYRHNSNMRDDPFPSNSNRRNFDSPSSRFFGRLQDQPIFNDKDILPRDVPLLTPNKIPVSALSPEVVATCTPDCTALHCTNECKCAHTHKVVHQLCNPPANAHIANHCQAWYNKCPMFHPIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFN7</accession>
    <name>A0A0N5BFN7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFN7"/>
    <dbReference type="STRING" id="174720.A0A0N5BFN7"/>
    <dbReference type="WBParaSite" id="SPAL_0000480300.1">
        <property type="protein sequence ID" value="SPAL_0000480300.1"/>
        <property type="gene ID" value="SPAL_0000480300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000480300.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12814" checksum="DC8F07BB19587501" modified="2015-12-09" version="1">MMLLQKVGRTTSRVINYNILRMLPGSIGSGPGSGLGHGGGAGGSIREGGGAFGKLEAAREAEYFHKLNNEQLKKMRDHLVKEIEAAKEQSKKHEEAIKRNEEMLKALEDHSEKYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFZ1</accession>
    <name>A0A0N5BFZ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFZ1"/>
    <dbReference type="STRING" id="174720.A0A0N5BFZ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000489900.1">
        <property type="protein sequence ID" value="SPAL_0000489900.1"/>
        <property type="gene ID" value="SPAL_0000489900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000489900.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43636" checksum="E78C8AA84C0D6676" modified="2015-12-09" version="1">MWKNPKKVYACGFASTGSFGIKNLILGETKTEIINKPKKISFFNNKDISKISSGFGFSLFANKEKLYGAGLNNYYQLGKAPVKSGFKEKEPDKWYIHPKEIILPNDCGKIRDISSGRLHSLILTDSGVYGMGDNAHGQCGFDNDSVNESVLKNKKIDVWGKIELDTDEEIRKILCILDTSYILTKSGKLYAFGLGEDGQVGNGEYGIFKKPTLVGGDITNEHIVHISGSTDTLIALSSKGDIFLWGQNEYNQMDLITSNLQLNLPKHFPLNIGKIVSTAATGSSCIVCTETGQVYVWGHQILGLGPRVTSTVKPIQIESTIFSTNQATDSFVKSVFAGSTSMGARTSDGNLFTWGFNRYGELGLGKKEKQLFPYPVFLPEEVKALELGYDHSLFITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG40</accession>
    <name>A0A0N5BG40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG40"/>
    <dbReference type="STRING" id="174720.A0A0N5BG40"/>
    <dbReference type="WBParaSite" id="SPAL_0000494800.1">
        <property type="protein sequence ID" value="SPAL_0000494800.1"/>
        <property type="gene ID" value="SPAL_0000494800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000494800.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39571" checksum="5044DDAA775B31EE" modified="2015-12-09" version="1">MDEIGDSRRSNGPENDENFNTYDVYDTIEFIPFDKCRYENFKMRKKFSTSGHRVNSIDISPLGDYMVSSINKDKIAAYNILVGSKSKDIPSQKYGCNQVIFAGESSRVLYTSTKGNDDIRYLSLEDKKYVRFFKGHKDEVLSLSMSPDGTNFLSSSRDGTVKLWDLRSDECCKSDHYINKNPIVTYDPKGVIFAVSEERNTVKLFDSRNNTLPPFRLFGFHSYAGKINNIKFSPDGRKLIVSGNGTNFYTIDTFSGERVAFEGIKNPNKRKFGVDYSPCGKYIIAGSDCGELIYYNATTGSIIKKFSSTHDSFVSNVAFNKKYLMLVSGGRNLIWWTPDYDDEVFGGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGD7</accession>
    <name>A0A0N5BGD7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fam-b protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGD7"/>
    <dbReference type="WBParaSite" id="SPAL_0000504400.1">
        <property type="protein sequence ID" value="SPAL_0000504400.1"/>
        <property type="gene ID" value="SPAL_0000504400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894467" evidence="1">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000504400.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21780" checksum="C645CF01C6AEBB10" modified="2015-12-09" version="1">MSIITHKNILIFISAINILNVICLHTEDNEKYNEIYDRDKITYFDNLKLTPRTTSTPTPSNILKNIINIVNDEDKSFDEIIDDLTAISDISEDANVEKNLLILKKQIKEYYEEYKYKIDRIIRKIQSIKSKSLENNLYNHNVVKWEPKDDGNDIEIEHVDQKNEGDSKDYMSEVFAENLFKNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH77</accession>
    <name>A0A0N5BH77_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH77"/>
    <dbReference type="STRING" id="174720.A0A0N5BH77"/>
    <dbReference type="WBParaSite" id="SPAL_0000532200.3">
        <property type="protein sequence ID" value="SPAL_0000532200.3"/>
        <property type="gene ID" value="SPAL_0000532200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894601" evidence="2">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000532200.3"/>
        </source>
    </evidence>
    <sequence length="355" mass="41027" checksum="F5FA452932FB0D19" modified="2015-12-09" version="1">MLLLFFSTFTFFIYNYGEEVYEFETYRVESVRERLIREGKLEEFMKELENTTEEPKRDNETETEYYAWRRKKVVVQNLFSFFDVQYLGNISIGTPGQKFRVVLDTGSGIEKNPCNGKSAFNSKKSLTYKNKRRKFQVRYVNNFASGNIGEDTLQILGRKRTRIKMKKIEFGQANNLPSNGDIYPFEGILGLGFRTIANNDMTPPLISTMHRKILAKPLFTIHLRLINGALMNKLKYNHGLEAIADTGTSFVGAPPAIVERIANMLKGQFIPQYGLYFVYCAKKNNGLKIKLHKMNIKIKRKHFITQFRNLCRLNIFPYASGGYCPAFISGDPLHQSYCVIYDIGNKRIGFARPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHB3</accession>
    <name>A0A0N5BHB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000535675.1">
        <property type="protein sequence ID" value="SPAL_0000535675.1"/>
        <property type="gene ID" value="SPAL_0000535675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894273" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000535675.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15772" checksum="E6712ADD3C64CF19" modified="2015-12-09" version="1">MRVLIIFIIYISISLSNSCSEFTDCILKVEGTPKCPPKERKTVDLKIESRETWRPIASASNDCDKKISVEAKLSYFSATSYAYWARFYYFRGGFYTRKIPEECIKGLQRKDDTYYCNIGIIDPSKNGTSSTNKPYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHQ2</accession>
    <name>A0A0N5BHQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000548900.1">
        <property type="protein sequence ID" value="SPAL_0000548900.1"/>
        <property type="gene ID" value="SPAL_0000548900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="183"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000548900.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37408" checksum="1D3D15F859A7B839" modified="2015-12-09" version="1">MYIFQKNNARREGSVSLDLIQNDLSSNNSISQDNLIHSIIGNIENEYLRKRQVDNKRRQIKQKSATQTKSKTNVQGKRPSKPKLPASKPPLTRHTTRKLSNVKITTRKNTAKVTTTRKSIPTRTIKPTTKPSSRTTTNKPVISTKKSTPSKTTPKITKSTSTVTTTRKRINKSKTTPKPDEYAHLKSRLISDINDLRRKHQAKNLTVDTTLANLAQKIIDEPVIIPEETVNKSVGYLRNFAPSEMYFNPLLEWGYKPEDNDYKNLDKNPFYAKFVQLVWIATTNIGCGIRNNGPNKGISTLCLFYPKGNIPGQYSENVKPEKRKKNKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIM8</accession>
    <name>A0A0N5BIM8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIM8"/>
    <dbReference type="STRING" id="174720.A0A0N5BIM8"/>
    <dbReference type="WBParaSite" id="SPAL_0000580800.1">
        <property type="protein sequence ID" value="SPAL_0000580800.1"/>
        <property type="gene ID" value="SPAL_0000580800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="368"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000580800.1"/>
        </source>
    </evidence>
    <sequence length="774" mass="91649" checksum="58E94B76396CD2DB" modified="2015-12-09" version="1">MSTVTILEGVFYGTIDSQIIPKIKGMYSYDELNDNGERLINFCTQNRISIVNSFFKKRWWNSWIKLQSIEDNIKGRLCVKQLDYFLCNMKRIFTDVETWSHKKFDATVSDHRLVKATIKFPKKLCDYIKKSRCLQKKVLHYNIKYEKSLNEVGEKELIIPSNEFKNVEKEYSKFIKEIKRVTKLVTVEKQIPSTRYSEHVKSLFSNRRKLLNSISYSDNNEDKKESKVKILIEIRMINKLIRQTIKNEWNSLVHDRIKEALENNKKIKSVFRVLKERKEALPVKVENINKYLNDLYLIKPEDKKRLKKLEITRFINNDITLPFLESETRAAIYSCGKNKMKGVDGLNAYDLRCLGNKAIRYFTLICNMCLKQVKHPSEWKTVKCLFLYKKKGNKDCLSSYRPLSICSHGYKIYAKMILNRIQKKILDEISETQFGFRPKYSCSDAIVCLESIFHTHHTYKLNLLTALLDFRKAYDLVYKEYIWYNLNKIGIEKFLILILKDLNVNIKCIINPEYGSDITIYPSRGIRQGCPISPLLYNFNLEMALRNAFMNNNMVFKYGVNITGSKVPNLCFADDTCLLANSWNDLSLMVDKFIRACQPMGMELNLNKCKIQMSKELSIQYEKDKHIPLNLTDMQISKEEEYLGKMVSITEKRCFLKQVRNRAWKVFYSIRKYLNISLRARKLLFVTRIRSSMCYAAQSWTTTQAKRNNLISVERSIIRRLKLIRQDKWLIKEDDNTFKKFSNEDMYKEIRICNLNRHLAKLKIKFIYKKIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJY6</accession>
    <name>A0A0N5BJY6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJY6"/>
    <dbReference type="STRING" id="174720.A0A0N5BJY6"/>
    <dbReference type="WBParaSite" id="SPAL_0000625300.1">
        <property type="protein sequence ID" value="SPAL_0000625300.1"/>
        <property type="gene ID" value="SPAL_0000625300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000625300.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="65994" checksum="B35F8EA16214359B" modified="2015-12-09" version="1">MPQCEYVSSSTGVRCSNSLPDIKLDSRNHCEIHGFVNYVYDNIVSAKQQRIGAPPKLEIKVTDVRGNIHDKIGWVGGRDDEEMLRCSSDWLQYNNFEADDNMFYENFSGTTIHGNGPFTELEVLKNQEIMINEEIKMLEKLKALNDEELASKNAFYRHAMLQELCSGAFVVRTPEEVRLCGEIQDLYKYGASKEREHESLVYRSNVYRCQKNDLQRIEDESRDRGKRGISESLSEKGDNGCEEEDWYLRKCCLESLENGKCDEVVLWPSAYCYNHLKFDKNQLLYESCQECQKPYIPPLECTNCLTNQRIEKSKQLVNQNPRMLNVRPNFDIRRNIPTMRMKGFDSSIVIPIRKVYVKKIDDITSHSKFELKHIKDEVEVDLNDVRGKELLEDVKENIVFGKDSGEGTSIELIDNYFSEIRLPVKQLPPKSVTQVPPTVTLPDRRHNPFTNVNKPPLALSKPIGVLNSSVNQKFTRGPQRTPRRTFEAIRLHPILGAQFKQNPCAKIRPFTKEYFPASEGSLQMGRRPYITTGNNVQKIKMIVMKPVVSSNSNSHSAPPRPSGAFYFRNTRTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK74</accession>
    <name>A0A0N5BK74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino_oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK74"/>
    <dbReference type="STRING" id="174720.A0A0N5BK74"/>
    <dbReference type="WBParaSite" id="SPAL_0000633800.1">
        <property type="protein sequence ID" value="SPAL_0000633800.1"/>
        <property type="gene ID" value="SPAL_0000633800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21197">
        <property type="entry name" value="UDP-GALACTOPYRANOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21197:SF0">
        <property type="entry name" value="UDP-GALACTOPYRANOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000633800.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54599" checksum="C586B7A12B5467A3" modified="2015-12-09" version="1">MDDKPVKKFVICGAGPTAFGALHRLHQILSNDILRNDLPFVPSILILEKEDVVGGLARSVTDENGFVFDLGVHVVSESKYPVFIDAMHDAIEEWNVVLRNVKADFHHIIGKERRIDSYIPYPVQENIMYFPDDIKNKCINELKELENNTKVCQNFGDFIENHFGETLKEIFFKPYNEKVWTLKLQEMSNEWVYGRVPKIKINKLVNPSNVKTNDKNRNMMTFRYPSGCKGVGNVWTKIGEKYPKEYFRMLCEVLEIDPILKTIDVINKSTKKKSKLEYDYFISTMPITLLGKMTSLAPSINLKHSKVILVGYGLTTPQNKFSKSHSWLYFSSPDIIFYRATLISNFSIDLTPDYKKYWSVLCEIGLKADEEDNEKEIMEKTLKDLRSCGLVDELNKVVSKFYMVLQYGYPIPTLERNNELQKAHLIFEKHDIYSRGRFGSWKYEASNQDTAFTQGYEVIDKILYGKEETLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKU1</accession>
    <name>A0A0N5BKU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-related protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKU1"/>
    <dbReference type="STRING" id="174720.A0A0N5BKU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000654600.1">
        <property type="protein sequence ID" value="SPAL_0000654600.1"/>
        <property type="gene ID" value="SPAL_0000654600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000654600.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46181" checksum="C802C4BB38182B66" modified="2015-12-09" version="1">MEEYPLFILDNGGYQYKAGFSQDDKPLVFPNGLVKCKNDRKRLYIGSEFAELQDKVGLYYQMAFEKGYLVNWDVEFQVWEQMFSANCFNLSLCDTDLVLTDPNCNIPAVKDCSYEVVYEYFGFNGLYKTSSSGLVALDSLKRENKKLCLVIDSGYSFTHILPYVDGKLVADNVVRIDVGGKLLTNQLKDWITYRQLNVLEETYIINQVKEDCCFVSLSTKLDFEIARRSFPYNTIKCEYVLPDYVTLSKGQKLSPGQFSTAKYPDNQMIMLNTERFVIPEILFNPSGIEINQMGISEAVNYVIDKFNEPFRGGLFSNIKPIGGNVLFKGFKDRLYSDVRSNCDASFNVSVNMSVNPLEEAWFCGKRNAEYLRKQLISKKEYDEHGVNYCKKKFLDFYHLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM15</accession>
    <name>A0A0N5BM15_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM15"/>
    <dbReference type="STRING" id="174720.A0A0N5BM15"/>
    <dbReference type="WBParaSite" id="SPAL_0000696100.1">
        <property type="protein sequence ID" value="SPAL_0000696100.1"/>
        <property type="gene ID" value="SPAL_0000696100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="269"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000696100.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="41676" checksum="D6B1AE1D6639B92A" modified="2015-12-09" version="1">MVPLSDAYIVSCVRTPIGGFKSTLSSLSAVELGTIAIKGAMEKISLNPEVVEEVFMGNVCQAQNGQAPARNAALKAGIPITAPATTINKVCSSGMKAIIFGAQAIKLKDRELVVCGGMESMSNVPFYIKRGELPYGGFNIIDGILHDGLTDGLLKLHMGECVENTASTNSITREEQDEFASLSYKRSTNAWNSGAFNNEIIPVVVKDRNGEKTIDKDEEYQKFNPSKMKTLKTVFKKDGTVTAANASPLSDGGCAVILANENKIKEFNLTPLAKIIAYDDASIDPIRFDQAPTFLIGQLLKKAGLTENDISRYELNEAFSTVVLFAVKRLGIDIEKINVHGGAVSLGHPIGMSGARLVTHLAHTLKQGEYGLCAICNGGGGASGMIIQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM66</accession>
    <name>A0A0N5BM66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM66"/>
    <dbReference type="WBParaSite" id="SPAL_0000700700.1">
        <property type="protein sequence ID" value="SPAL_0000700700.1"/>
        <property type="gene ID" value="SPAL_0000700700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000700700.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16210" checksum="D1B8B8C3EC4B5D50" modified="2015-12-09" version="1">MLHLNEDSNKEKINRWTKSEISDFQGTSYSNGDNSETTEQSMKKDYIDEKPVPIKIVDAMLVKDGRLCVYLVEWKKKNEDNFFSYVRMKELPREMVTNYWDTQKKLGREIMEALYVIYDPDVVLCNNLFGNYPFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM74</accession>
    <name>A0A0N5BM74_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM74"/>
    <dbReference type="WBParaSite" id="SPAL_0000701500.1">
        <property type="protein sequence ID" value="SPAL_0000701500.1"/>
        <property type="gene ID" value="SPAL_0000701500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000701500.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38521" checksum="92D0918155FC42E6" modified="2015-12-09" version="1">MEFINLPEDFKLQIFKELQWKDINNLKLVCRDFYFIITKNIEQLDREELNCLTIYYDKNKIIKVEYRQVSNNELDINDILRSIEFNDDNEYEIFLRNRKIINIKELIFENITKGDTITIRDYEYYYFNINYDTSTTTNRAYEICLSKEYGACNACLTISSINKIIEIPYNTGTLKKELLEKMSIFKKDNYYLIISKIVLDILTNDPMLKHENISTINTNIEPIFSNLIINMHKLGFLEFENNGRCSSKELYLCYSGEHEINAEEKKFYTELFNEIKHEDQLLIIEERNFDIENFKICLECGARHINKITLEDSNNYRILELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNC8</accession>
    <name>A0A0N5BNC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNC8"/>
    <dbReference type="STRING" id="174720.A0A0N5BNC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000740700.1">
        <property type="protein sequence ID" value="SPAL_0000740700.1"/>
        <property type="gene ID" value="SPAL_0000740700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF4">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="164"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000740700.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="48275" checksum="36FC8B03EC44F70E" modified="2015-12-09" version="1">MDSNQNLQLSEYCLVCNVPTNSIHFGVNACKPCSSFFRRTAIAGKTYKCRKATKNCVVTKDKNRMCRYCRYEKCKQIGMALKNSPSINETSLYDDRYIKSPQQDFKEKNDFTRQTTVIKSTFEIQNCKVITNFNETIDKIKSIFKFPIIKNTSSEELPLTNLQLVTKAINNLKNAMICVKKEDLKLLDVFNISSFFEYFKCFLVHYSKFLTELPNFNKYDYEVKMNYLRYSNGIIFVFLKLYISLEVFGYNNNSSNIIVNHCSFTNAENGPLIDPSLPEDFAQNLAKLFYPIEKYQINSIYNPMKRMMLDKYEFSYLILQIIWSNCNIPNLPNECYIENDRMLKIVNNELHNYYICYKNLDNYAFRVVEMMKLYTSLKDCETIHESACTLGRAFNIFDCNIFDTELAKTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNP9</accession>
    <name>A0A0N5BNP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBFD_NFYB_HMF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNP9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000752600.1">
        <property type="protein sequence ID" value="SPAL_0000752600.1"/>
        <property type="gene ID" value="SPAL_0000752600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000752600.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23583" checksum="AF8CD131129BA2BF" modified="2015-12-09" version="1">MDSNSTVPDNIDGIFAVPQIPSSAINSIAGPSCTDSQAGVPPRMRKRKFGGAKIQPSRVKKVMQSDEDIGRMMASVPVAIGRAMEHFCEKFLEATSRCVSASSSRTMNPSHMKHAIMINPQFQFLKNIMKDIPTPKNIDNNAASVSSSPSATPLHQTQFQHNSSIVPTSPTHVTDLNNSKPKRGRPKKIKLDSTDCNSYMNGIFVQQSPIEGSTSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQR5</accession>
    <name>A0A0N5BQR5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQR5"/>
    <dbReference type="WBParaSite" id="SPAL_0000822700.1">
        <property type="protein sequence ID" value="SPAL_0000822700.1"/>
        <property type="gene ID" value="SPAL_0000822700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000822700.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10677" checksum="176CAD0A52AB15E9" modified="2015-12-09" version="1">MILAQRAHVPFGSPFSLMAKVRSYRRPEFYLKVEHNCQQTNSGQNMTSILPIPSQYVTRVVKNKFLGKGYYLKNLNLFVLKGSRLRMHMSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR32</accession>
    <name>A0A0N5BR32_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR32"/>
    <dbReference type="STRING" id="174720.A0A0N5BR32"/>
    <dbReference type="WBParaSite" id="SPAL_0000833600.1">
        <property type="protein sequence ID" value="SPAL_0000833600.1"/>
        <property type="gene ID" value="SPAL_0000833600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="239"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000833600.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67518" checksum="0ADAEB14AE3311FE" modified="2015-12-09" version="1">MNTNLDESDKLEKPLPQNQSFRETLHKISTKDNLIGAVVKINDVNVISLIDTGSNCLIISNKLKDKLNLVTCNESQISTYQSSNAAYKIETPITIQIQKESFTLTDNIYAAKENFKNDSYDAIIGTNILKRLMAVIDLQTGKIIMNKNKKPVHVENQSPTTNVILGNQDDNVNINEFVEKLKLKYPLAYAKHAFDIGPGKIVVNEIEIYENKEMIKAPYYSVPIHEKDSISQLLKCWIENGLLEKSSSNLIHPIMLITKNNDKNDFESRRFIADLRQVNSITKPVNYNTPKIQELLQSLNAFSFITKIDLKSAFFQLSLPENSRKLYGIRTPIGNLQFKRLPQGGKVSSAIFQRTMEEVFQKLRNNCLIYCDDILLYSTGTLLDHEHLIHQFMEICNNLELKVSLEKSVFFAREAKFLGYHITSQGSKPDISNVNSILQRDVPKRKKQCISFLQAINYFRNVIPNFSRTAAPLYEVSKGRDGPITLNEEQLQCYHALRQQLMNSPTMHHPIHGLPFLLTTDSSNHTIGAILSQNQNGTEVPLSFFSCRLSPTKRARSPTFLELFAVAKSLQHYKYLLSSAEVIIRTDHKPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRR6</accession>
    <name>A0A0N5BRR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000856100.1">
        <property type="protein sequence ID" value="SPAL_0000856100.1"/>
        <property type="gene ID" value="SPAL_0000856100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000856100.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51014" checksum="2C39C7140147C341" modified="2015-12-09" version="1">MVTETSDDIQINLKINNVGKLINILLHHSKFNDDTPIETTSDRNDYLSKLYSEIRSLNRKVELGFQKTGYYLSQLNERMLNIERFIIRYDHIMEMRLSSEENFVEKSQLNNVNISKEQDFGEKKEETTISFSSVKDSANSEDFNTLDESLESGSTEIRTDGLPVFSDNICIGDFEWNNNNLKEDDSDSSESLCESCPDFIKGNVCISESEAPSCPSIESLYCEDTRYNSDSDNVSSTRKDRNSNYFDAEEFKLNNNKELPDNFEKHSNTESTNMSESSKEWINNVEPKEDKRLFGTFNKYLGTDKFYSGSMKVEFESTTSCIITYYEESNDSGPNKITEVSYKIVYNNDIGEYLLVFEEQEPMKSKLIVRINNNLNFLISEIDSNAVICEYITANQSSETPIQWTVFLNQSSETPIQWTVFFKDDLDAAKFLSLIRCFQRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS18</accession>
    <name>A0A0N5BS18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS18"/>
    <dbReference type="STRING" id="174720.A0A0N5BS18"/>
    <dbReference type="WBParaSite" id="SPAL_0000866400.1">
        <property type="protein sequence ID" value="SPAL_0000866400.1"/>
        <property type="gene ID" value="SPAL_0000866400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000866400.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27301" checksum="C14CE061A7E2D37F" modified="2015-12-09" version="1">MEESTEDDEYFSLTSCLICPSPLSKCKYCNVSLNECKLEDHYTICQNAQWNRQCLSSDAKKALKKYARYEREDEIKIDLSNAIDIIAAQLDQQLIEEYFLVPRKDRVNFRDFFNPINPPLPLKLKIRDTTVDNKDKSGATKLLIHDSSDDEKEEKLKARKKKKTPYENCYLCKLDPTAQHLHVLGNQNTANNDEDNKDNKEVNDVAKKILEPFYESNNLYVSLTDEKSCLLYLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BS78</accession>
    <name>A0A0N5BS78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BS78"/>
    <dbReference type="WBParaSite" id="SPAL_0000872300.1">
        <property type="protein sequence ID" value="SPAL_0000872300.1"/>
        <property type="gene ID" value="SPAL_0000872300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894783" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000872300.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12547" checksum="2112F26F29B559B0" modified="2015-12-09" version="1">MHFIKYFTIFVLLAVQYSLQDDTTTYGTTPAYMYSYDYGDSSFGTTQESPLDYVNREKRSLKDKFKDVKSKAKDLVGKAKDGAKKLAKKTKDVAENLVDKTESKFRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSP2</accession>
    <name>A0A0N5BSP2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSP2"/>
    <dbReference type="STRING" id="174720.A0A0N5BSP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000888400.1">
        <property type="protein sequence ID" value="SPAL_0000888400.1"/>
        <property type="gene ID" value="SPAL_0000888400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="127"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="320"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000888400.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="64654" checksum="72A040511A96AE07" modified="2015-12-09" version="1">MNVEKKVLKRKLNKFKLAKKKKKQINEEKAEPIVEKKDETSSEDSGSEQEESQVSKNISSPSESNSANDTKDTDKDAVEDTKLKSNKKGILSDVKFSSLKDSVNSKLLKQIETMGFERMTHIQAQTIPALLEGKDVLGSAKTGSGKTLAFLVPAIELLHKLDWKPYNGTGVIVISPTRELSLQTYGVLTELLENNSNLSHGLVMGGSNRSAEAQKLEKGVNILVATPGRLLDHLRNTKDFHYKNLKALVIDEADRILDIGFEIEMHSILKMLPRVRQTMLFSATHSPKVDELVKEALHADPIKVGLEEQMYWEEHATVEGLEQGYVVAPSEKRFLLLFTFLKKNRNKKVMVFFSSCASVKFHAELLNYIDIPVQSIHGKQKQQKRTSTFFSFCEASSGILLCTDVAARGLDIPSVDWIVQFDPPDDPREYIHRVGRTARGDSGTGHALLILRPEELGFLRYLKASKVTLNEFEFSWNKVANIQLQLEKLINENYYLNKSAKEAYKGYIRAYDSHSLKQIFDIHTLDLLQVSKSFGFSAPPYVDLPITNKSGKAREKPSGAGYIKKGKTAFGGGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSQ2</accession>
    <name>A0A0N5BSQ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BSQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000889400.1">
        <property type="protein sequence ID" value="SPAL_0000889400.1"/>
        <property type="gene ID" value="SPAL_0000889400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000889400.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8787" checksum="3C6EB76F47F52412" modified="2015-12-09" version="1">MSRIHPPELNKYLNKYIDVKLTGNRHVSGTLRGFDPFMNIIIEGATEHLKTGETKEIGIIVLRGNSVVIMEPRERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU70</accession>
    <name>A0A0N5BU70_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU70"/>
    <dbReference type="WBParaSite" id="SPAL_0000939000.1">
        <property type="protein sequence ID" value="SPAL_0000939000.1"/>
        <property type="gene ID" value="SPAL_0000939000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894861" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000939000.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18332" checksum="D764E6DDF6390A2E" modified="2015-12-09" version="1">MRAFKTLTLFTIISISNARLLHFPVFNLERDVSPGTKLLTIIGTPECLFINPFKLELTDNVTAQLGTKTEYYGNTNVTVSCNKEIKIEAIVDENDITSGVFVVRYFYHVTELKFTKKIPGECKDKTGEKVQGRFICKFDEINPNGRKIMSPGNYKYMSPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUB8</accession>
    <name>A0A0N5BUB8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUB8"/>
    <dbReference type="STRING" id="174720.A0A0N5BUB8"/>
    <dbReference type="WBParaSite" id="SPAL_0000943900.1">
        <property type="protein sequence ID" value="SPAL_0000943900.1"/>
        <property type="gene ID" value="SPAL_0000943900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000029">
        <property type="entry name" value="Aldo-keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000943900.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36143" checksum="2671CD1BF4E07D15" modified="2015-12-09" version="1">MSSPGTASITLSNGNKMPLLGLGTWQSPPEDVRNAVRVALDNGYRLIDTAKCYENESEIGEVLQEYFMSGKLKREEVFITTKLWCTHLRKEDVESELNGSLKRLQLDYVDLYLIHAPTCYDYEFKEQDHSVKVEDTWQGMEGVYEKGLAKAIGVSNFSNEQIRRIMNVAKVPIHNSQVELHIYWPQFDHQQVCDEYKISLTAYAPIGSPGRFNFKLAHFEESKEALSDEVATKLAEKYNKTTAQILLRHLIQRNIAVIPKSVTPERIVQNSKIFDFTLTEEEVNELNAVSYRKRLFKFEFSIGHPEDSLIKERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUI2</accession>
    <name>A0A0N5BUI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUI2"/>
    <dbReference type="WBParaSite" id="SPAL_0000950200.1">
        <property type="protein sequence ID" value="SPAL_0000950200.1"/>
        <property type="gene ID" value="SPAL_0000950200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000950200.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22713" checksum="4002685E144814E7" modified="2015-12-09" version="1">MNINYLNFGYINDNFTHIFIISDIAFQISLMSLVNNNCESNSNGIVFDGDRKILPLKIENKDSSISEYYKFLKQNLVKESTLLNINDECIEKKFIPNVKNEYQNKLLNLKMQEMLTLRKLTKIKQVIKNNNYKIYLIDKIKVLSKTFDPFIFNTQISKRYKTNDEMAESDITFVRALRNLQYQLHKLNNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUX2</accession>
    <name>A0A0N5BUX2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biopolymer transporter ExbB</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BUX2"/>
    <dbReference type="WBParaSite" id="SPAL_0000964000.1">
        <property type="protein sequence ID" value="SPAL_0000964000.1"/>
        <property type="gene ID" value="SPAL_0000964000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000964000.1"/>
        </source>
    </evidence>
    <sequence length="61" mass="7185" checksum="8E0E5A3045A8F56F" modified="2015-12-09" version="1">XIMDILRFIIAIMFGFFFWHTLVILRIELKGLKESRATFKELMRKSPESINDNLSTDHSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVA6</accession>
    <name>A0A0N5BVA6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000977100.1">
        <property type="protein sequence ID" value="SPAL_0000977100.1"/>
        <property type="gene ID" value="SPAL_0000977100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000977100.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="65579" checksum="A3F69E44F89B4BB9" modified="2015-12-09" version="1">MDTKKISFINIMEVGLVRKKILGYLPNFKDIYCIASTCWELNQFITNEKITRNILYDYCQFNIKLVKINDKREFINVQEDSKFEGYVFENLDVLFAFKTKESEQYRRKRFICNDTVEIAFLTEEREDFRQKYVPFIKKLAQKYKINFEERKDLTILKLHDKNYNNSSIRLLHVLPYLYHENINTIIIPINYFSTFINKYNGLLNNLFNGFPKLYKLEFHISFCYIKIRNLIFNKDAIGEILRQLSKKNNATVHFKYFDDFDDISLVIKCFLLFLEFAMKYGIKITIDDETLRVLKFHNIPNILKRYNYSIEQHVTTCMDVIGSLHSDLHNCFKKMRYYENLEKVCLIFNYSLYDCSLEENFKAFRYIQSLNNLKKVVGLELTFVKHNTGISEDEIKIFHKNFKYLIRLLPSSVKRLYLYGIPKLTYDITKTIERYMPNIEVLSLYNISFEESDCLSVFKKLQAVAIRSDIPVKIPDSVKLFAVYTRESAEKDINQKLTNEYSKKFSKRLIVRNVKNIFFNDINDFRLYRHLIQIESILKHKNYFKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW29</accession>
    <name>A0A0N5BW29_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW29"/>
    <dbReference type="STRING" id="174720.A0A0N5BW29"/>
    <dbReference type="WBParaSite" id="SPAL_0001003400.1">
        <property type="protein sequence ID" value="SPAL_0001003400.1"/>
        <property type="gene ID" value="SPAL_0001003400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001003400.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32834" checksum="68E420475C2715DA" modified="2015-12-09" version="1">MSGELEKQESTTFVPESPSENSAPVIITLGMAGSGKTTFVKRLTSYLHERKTPPYLINLDPATVNVPFPANIDIRDTVKYKEVMKQFNLGPNGAIMTSLNLICTQFDKIMNILKERSNIVDHIIIDTPGQIEAFTWSASGSIITDSLASSHPTMIAYIVDSGRATNPTTFMSNMLYACSILYRTKLPFFIVFNKADIVKPTYALEWMKDFESFHSSLEEGKGSYMTDLTRSLSLVLDSFYENINAVCVSSKTGEGMEKVLEYIDKCKVEYFETYRPMYEERMKEQKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW81</accession>
    <name>A0A0N5BW81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW81"/>
    <dbReference type="STRING" id="174720.A0A0N5BW81"/>
    <dbReference type="WBParaSite" id="SPAL_0001008400.1">
        <property type="protein sequence ID" value="SPAL_0001008400.1"/>
        <property type="gene ID" value="SPAL_0001008400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000175">
        <property type="entry name" value="GM22099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001008400.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36810" checksum="F4F14B9E798921C9" modified="2015-12-09" version="1">MFELIYLIMGKDYYKILGIPRSASEDEIKKAYRKMALKYHPDKNKDPNSDGKFKEIAEAYDVLSDKTKKDIYDQHGEEGLKGEAGGFPNGGGGSGFHYTFNGDPFRMFTQNCPSDDMFKDLFGGGGFSFNGAGNSFFNGGMPGNGMGGHYKHKQDPTVQHELLVSLEDIAKGTVKRMKITKKVYGHDGKCRTVDKVLTIDIKPGWKSGTKITFPKEGDQYPGRIPADVVFVIRDKPHQYFKREGTDLIHVHKLSLKQALLGTHFEITSLEGEKIPITIDHIIKPNFHKKIENQGLPSAKTGQKGSIIIKFDIKFPDTLSAQAKSAINEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWG0</accession>
    <name>A0A0N5BWG0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEPDC5_CTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BWG0"/>
    <dbReference type="WBParaSite" id="SPAL_0001015500.1">
        <property type="protein sequence ID" value="SPAL_0001015500.1"/>
        <property type="gene ID" value="SPAL_0001015500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="1">
        <location>
            <begin position="122"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="DEPDC5 C-terminal" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001015500.1"/>
        </source>
    </evidence>
    <sequence length="1399" mass="164355" checksum="C639D7E11B414AA6" modified="2015-12-09" version="1">MMTSLSDKTLFEKNYSKKVEAITTTLVMKNHEQGTMEDDYIELPNNLIPGLRNDDLLHVRSLSSDNYIILPFTPSGANEKEVKLYTKGIENYKDLCNNRIFHSPYKVMIRRATKKEVKLDSIELTFNDCYVSRTDMWRLKQCLIDQCINLNQYFDFMNMSLRTAFLWRKGETKTSGFISKDTKVVFRSLCTQVLMYIQISDEMWHMDHQGDLYFEKCVKGFIPDLFKRWQEEKCGHHVSIIAVTRYHYKEEHLTKEIRQKLNIRYDYLSRPYQDFYYLLVQNECYNDWMTVMPKLKAALYDFRISIVDYHKINLPKCRITESFDVSSAADGCFLEVLNLSMNNFFLYHSDRKFETTGQQVIFVTPGCGVFYVDKQLVRFTKQRIIDAGISLDIVCLGEQPLHAVPLFVFREQGRESEEYFIPHWMNYSYYRRERSSLIVNSFKPRITFPEDLFQKTKPGLFMNVNDDEIEDMYEYDNQKEKRLSSCYKNESKVHLRKLKEELNINDSVTKVLNNCKNVEITIPQEVTEVIGITYDDLSYHELAEEAMEDENYSEDGDVLTGTVFSMDEDQNDFFTKKRKKSFENKRIRTFSNRGNKMNTEFGPESYDCQRTLYRERIKVQSPQGKSLETTYDVNKKRKKIVNSRFSAYNKFLINPFRLEASIVQISANRRRWIHVFPVDKRGRAMLSHHYICGINVLSKGEETELEKMDLNSGSDGKKSVWAWGSTGEEKWDPDMEIGCDWKSLVRPGLLPLTTDFFPDGQSLSSYTSSCHVVLVDRSLMMNWVEDSFLDSLKNIDGNREIKLQNHLDNLLFEQLIYQRLQRGFQIVLLPNCMIDSALNTAGFLTESEEDPIKQCAMSFSKFYHVLRLYNQKIVVEKLIPTSMCCPKIPSLSEESKGKIKSGILSSISKNTLSKNKEELIITNTSDTDCSKEVYKYLFQVPDMDSYIASTTTFKHHNLDIIEWKILDSNLQSRFCPKLYFDDDKIDLKAWSARFVLLPSSKAYMKNVRELQRGDVFKINMIIDKHLDEHLFHFSMFMQFLNPLSRPSIVFKNLERNPKIAKNNFNAIKKAFLELKQLKYKDLILDGMFILLEFMIFLKRSVHELEDWNLVDKYLDKLIQENLIKIAVPDPKNDQKKFRGFIYYYFPDILSKETIEYFREICPKSYLAECEVTLEIERKISRESTIKNRDNYRIEICPSKTFKTTYGFLGYKECAIGVYDKVFCIGKGYELQLRWMIATASNIIGIVKKWVHKADHYGLHIVPIPEDLFALATNVASSPLRAPIPIHFEYPGLSKEHKKIVANKILELFGFLPFKYSESNKTVQYVHITGGMFCMYQECHETFQWSWNHMFSDRSQTFKAECTEKFQDIMLSDFKKFFYGKDDERLSSLIDSLKINYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWS9</accession>
    <name>A0A0N5BWS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">THO complex subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BWS9"/>
    <dbReference type="WBParaSite" id="SPAL_0001026900.1">
        <property type="protein sequence ID" value="SPAL_0001026900.1"/>
        <property type="gene ID" value="SPAL_0001026900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="4">
        <location>
            <begin position="581"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="3">
        <location>
            <begin position="885"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1626"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1672"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1704"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1724"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001026900.1"/>
        </source>
    </evidence>
    <sequence length="1733" mass="200997" checksum="046542BE1879CFEE" modified="2015-12-09" version="1">MDFKYEPTSLNTNYQNYHSEILKIVEDNKDVKSAIVKWFTDNKINTKCPIVTTIIVTLKQQYDMMLQVVPDDIEIKRRHERILEIKEQAINFLDVKKESFLIFEKQQDITNDEEKNCFITAQKLCVKQKTQLFYKISKSNVAIEDTGLASILFFNDTNISLEKQVLSEEDQDELANKNYRDFLEFSFNHNMDQSKIFTIILQKLNDTPSMSFYYITLLKNMKFSKITLKTILNEVDRNINISKDISFLSSGAAFAFIAHHNLIDSKELYYMLSPNKYSDIVLLNKKIEENYDKRIKVASKVKVDYSKLNYNMDMIDENAPAPKIVSAPTFVTASEVIEFQNKADKKVASEIDGWEKICVTHRKLGYVWSLFRIHRHDLALPLLETLPSQLVINMMPNIGIIIGDIIMEKLAVTFPNDSKYRTTLNEIINSLNGSEKLIEIVDSLQSLIFLSGPYLGKHFFVCKRLIDILTAYLQCNEDISLISPQHFNLIETLVTRILIPGIAFTSSAEEYSCKLNKLLKLFPIEKRYKMYESWIKDVGIEYRSIGLAQKKVYALMKFYSNRISKDNARECFKELSPFIEDHPYEALKCMIGMIQTNDIMIPILVDTLKVMTDLSLDVLGFTIYKYLNENFKKWVDNDDLLSIKNISKFVGRIVAEHGIDVTCILQFIDDKLGESNAYILYLLGEIFYSFNYKISQSSLTNEQVVAMAGGEFLQKAYEISDITKAKVDWNELCMALKNNGTFYSIYKHLSSTKLSLKELSLETIDQEGQQNYLALKDMCQDVLNQFIHIINDELIPNSSSIDKIPSMTHLLQDNEVKNIELSWSIKRLAFWESVKRIFEKKCKNHVFTSTENIDSKKHKFCKDAIIKELEKVEKDINESNFYQYKHMPLRFYCLFWLCSVDTLIFPSSKYKEKINEIQNVRIYEDRFDDDYDRKKRKEDDSKRKNLISDLEKEQKDLKPKRRRVRKIIASLLSDVVNGTDGSRNDNGCFTSDFCKEFVSCCIMPRYQLSRYESFYCSIFVRTIHDLSSTKISTKEILHEIFHEIPIGISQYSTDECANCGLLLLKSFEISDDVYSEIKKNGHDSKKQSESMETTTSNENNADKDKKSSVKNNLTFDFNNQVVSEEVFTFIYNEQDILCDHILKLLNRDEMQTHVNVLTVISEMIDTFPKFKDHCKKILDIVETRSQDPELKKTKVLPLWLTIQRKLKDKKSLVDGPKKVKTDKKEKRLSKSKEDKASKKSDKENEVKEKTNKASEGTLSAKASSVENSGKHSKKDSNNSHDHSRENVDIKDHSHENIQENDSLVRPSRALSKDSNKGKSESHSSPVKSQGSINDKENGETDTKNENPSTPKSSDSFSKRGRSLERNKTVEQTDLRSKSSDKNYISNGDVKVPDPPQDGQKPVKQNDDSKESSNESNSKYKYNKLSKENDKKESSQSSDKSSLKRQRKNHDTPSDRERSSKVKKSKDSFEKRRKLDKVSDKKSKRKNESSQMLVANGAEAITPDSPEKESFGFTENSTKYRGYNNRKYSTKRVSSPDLRGQNDTSADELSKLSDDKTNDDKDKIPEEKKKVDDKKYTEENRKKFSDEKRFSPYKNETNDEKKKDKSFQGNSSEDLRPVSISPDNIDDSEKNKSLTSKEEEKIREFSSSFKYYDKEHDRKFNMNRTKITGPNSENDRNNYDSSHKRRISSYRQSDDYPSMSKKPRRDRDHSSSSRRYTDNKYRSDNRRHHGSSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXC4</accession>
    <name>A0A0N5BXC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-H</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXC4"/>
    <dbReference type="STRING" id="174720.A0A0N5BXC4"/>
    <dbReference type="WBParaSite" id="SPAL_0001045500.1">
        <property type="protein sequence ID" value="SPAL_0001045500.1"/>
        <property type="gene ID" value="SPAL_0001045500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001045500.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36208" checksum="3371B80B05B391A4" modified="2015-12-09" version="1">MYSTSTQKKNWTFSSKEELIAKKKLASEEYYKNYLPILTQEEKDELLFTVEEQTLYATTIGDFCLDFSDNFLPQFWPTVPWTAFMYYRRFYTKHTIMEYPPKHILLASFYLATKVVEFNVSAEQFVQNCRSGDPDENIKIILTNEPVVMQGMNYNLTVHCPFSSFNGHLLDMEVKMMLNFDIESLRELGNIFFRRCLYTDVGLLYPPSQIALAALKYALIKKGQNEGIVKEFLTKLLKIDSWNSEPASILIFEKLLLRIDEIIKFVKVEYESYSKDGFKTLMEKMAMWNARSQNANVSSETEESEDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY13</accession>
    <name>A0A0N5BY13_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY13"/>
    <dbReference type="WBParaSite" id="SPAL_0001067400.1">
        <property type="protein sequence ID" value="SPAL_0001067400.1"/>
        <property type="gene ID" value="SPAL_0001067400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001067400.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25646" checksum="A9B2F564986AA2C7" modified="2015-12-09" version="1">MRVILFGFPKIKIILFAVIFIIWLISAISFVRSNDGGNQLLSRVDQTDDLIYRSKRSRRKSKSNRNNIKQKHNSNVDNSNNKGNKNNINFGNENMDNFTRGNKNQSPLPSRSKINSRRRRRKINHRTGNNVYNRDESLYDANFYDYKNYYYYDGSEEGKKNIRKIKRLKENIKQLKIAIKEAKAALSTTTESTITTTRISKTKKVSKFRKSNNHLDSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYM7</accession>
    <name>A0A0N5BYM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYM7"/>
    <dbReference type="WBParaSite" id="SPAL_0001087900.1">
        <property type="protein sequence ID" value="SPAL_0001087900.1"/>
        <property type="gene ID" value="SPAL_0001087900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001087900.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22104" checksum="88CFBB7F2DA37CC8" modified="2015-12-09" version="1">MYQGNACNHSVEGKQKSHPVQGIYYPQQLAYQNEMSKEGNDSTKSKIAHFSNNNLRNISTRRGMTRPASIAALSNSSFSFSSSQDISSHYVGTNINIPKNKISSKGNLPNSVCENNLKYPKEIQQLSTDMSNNKSKIKSSTEDEITKPNIIMRNKKSNSNVCGKEKVKKDRISSWRVSRFLPSKLANSFSNSMHCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYN2</accession>
    <name>A0A0N5BYN2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with signal anchor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYN2"/>
    <dbReference type="WBParaSite" id="SPAL_0001088375.1">
        <property type="protein sequence ID" value="SPAL_0001088375.1"/>
        <property type="gene ID" value="SPAL_0001088375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895056" evidence="2">
        <location>
            <begin position="25"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001088375.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="55862" checksum="C98FD8D516A646DC" modified="2015-12-09" version="1">MHSSYFWLATFFIVSYLMDSYSMGRQFFDCNTDNMDSFELEIPSKCYTYINYSWHMEVKHVVSYIRNKKKCISDLKILLVSKSYVIIMGESGISDDNILINYGNDPYTTYEKYPECLPKDKHFYKFERDLYISTEKEDYWAKKELSSSTIEQNILKKFERGNLINDALMLGINSFLLIENLNTNKEQILFQNLSNSFYVITGFDLNNNRINIEGGKEILRNKTQHLGNEIYRQTCTSKNNRLKEVRESHTPEEKVRAYLHRADVTGVSTDRENVIIVEVCKVFIPVKYFTDHSIDNMCYQYMPVLSEYGHLLFVDISNYVHHFSPSKKCTEVVDETKIKKLFVHNKGNHYENFVNWFLNIIHSLSKTLKMGWWSYNLVKHQIIIIMIAIIIIIVIIYFIIHKIFLKKDSYDWLWDILKLMFKKIILPLQWLYGIIFNSKKSEEIKGNTKKEREEMELDKMLDELKDDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ48</accession>
    <name>A0A0N5BZ48_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RECA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ48"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ48"/>
    <dbReference type="WBParaSite" id="SPAL_0001104400.1">
        <property type="protein sequence ID" value="SPAL_0001104400.1"/>
        <property type="gene ID" value="SPAL_0001104400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="5">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001104400.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19151" checksum="963110BF0882F27A" modified="2015-12-09" version="1">MEIEIKERKVYFFFSLVILILSTRFTDGKISNPIILRGIGEFFAVFQGRGELADRQAHLGRFLRHLLRLADEFKVAVVITNQVMYRVDDSANYGGNTKKIPTGGNILIHASTTRLCLKKGKGHQRIVRSMILRACQNMKLALWFQTKELLMYLRIFKCFVTILNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ93</accession>
    <name>A0A0N5BZ93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ93"/>
    <dbReference type="WBParaSite" id="SPAL_0001108600.1">
        <property type="protein sequence ID" value="SPAL_0001108600.1"/>
        <property type="gene ID" value="SPAL_0001108600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001108600.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7910" checksum="2BC0FD266A9D07E9" modified="2015-12-09" version="1">MIAITQEADNVIAIIRKTHKKKPAIVRKFLVILKNRYGGRKTSYEQLEMIYQASTFTYTLIDHGKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZS6</accession>
    <name>A0A0N5BZS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IgGFc_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZS6"/>
    <dbReference type="WBParaSite" id="SPAL_0001126600.2">
        <property type="protein sequence ID" value="SPAL_0001126600.2"/>
        <property type="gene ID" value="SPAL_0001126600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895362" evidence="1">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001126600.2"/>
        </source>
    </evidence>
    <sequence length="547" mass="59916" checksum="D15B26E9E735839E" modified="2015-12-09" version="1">MKISSITSIIFILSLTILGYGIPDSDGTKFITSFLYKDATNSSNFSLYLYFLTSVQNPGPVVVRYYSLVNKKMMLNSVAPEYGRVARLSFDYNDVISEGHFSTGMPLDVTDPRIFIDSTTPVKVIGHLFNRMNNQGDMYIVPPVTFAGTTYLVKLPKTGLMKLQLLHIMALENQNVNVEMISSTQGINLTSTQNFTINGNLGSPQKIVSSILSGSKKSYYFKASGPIIITAAVNGADLNGYLVNSNATVNSAIDYTAFVPQPIGVWDMKTMLTPKDKRVTVAENTVALDVSPSDVMGYNKLPILTFNNLNITNGVSAVIPIQQVTEYTIDHSQVTEFATQSSHAVAVWTRIGSPSANSNATLNGMYIHYIPESTQFYSGETQFITLYVGDYYEVYVENYTVGASLTLNGQNVLINDQTSRNLGFFNKTYTVVKITVPIAGLNVFNCSLNYVGYVISKTNGNTNTAYGYLTGFNKSKLQTYWASSETTTTAVTGSFTSTTTTTTTPALSGTTTTEGNKIYTTTKSSSRMNLNLISICLLLISKIFFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C053</accession>
    <name>A0A0N5C053_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C053"/>
    <dbReference type="WBParaSite" id="SPAL_0001138400.1">
        <property type="protein sequence ID" value="SPAL_0001138400.1"/>
        <property type="gene ID" value="SPAL_0001138400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895115" evidence="2">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001138400.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18653" checksum="1604D91C8B2D71E8" modified="2015-12-09" version="1">MKYLITSIILAIVVFVIIKGDEFGSPQPWEKWPGHDKFAKSVAEQAIKFYSKESHLMYKLSYVDSIEKRVFGGANRYRVKFCAKCVKAIKSSKGGKNGKGKKPVKGCTKKTKCELFKAVLRDEKITGNKKLTVTNVATETTYVSTKKPPVVTTKAPRKPKNILKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0H6</accession>
    <name>A0A0N5C0H6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1681 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NECAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0H6"/>
    <dbReference type="STRING" id="174720.A0A0N5C0H6"/>
    <dbReference type="WBParaSite" id="SPAL_0001150400.1">
        <property type="protein sequence ID" value="SPAL_0001150400.1"/>
        <property type="gene ID" value="SPAL_0001150400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000064">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NECAP PHear" evidence="6">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001150400.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20782" checksum="BE6D421597E20FA2" modified="2015-12-09" version="1">MDDYESVILVKPEVFIYRIPPLTTAHGHRAADWKLDAPDWVGRMRLIAKGQKLELCLDDKTTGELYAKAPIDSLESRAVEAVVDSSRYFIVQLRSDTGRTAFVGMGFADRSDSFDFNVALQDHFRSLQKEVEIDSTPKLDLGFKEGQTITVKIGNKTSTPRPKTSSSSGGAVPLLPPPPSSSNRIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1A4</accession>
    <name>A0A0N5C1A4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001178100.1">
        <property type="protein sequence ID" value="SPAL_0001178100.1"/>
        <property type="gene ID" value="SPAL_0001178100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001178100.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20674" checksum="FD56D5B12A0A3300" modified="2015-12-09" version="1">XFDPHSMDQFGKYCSNGVACMIMFNTISDLIEHLQANQVCNNSIFDLDGVNISVENISESNSDIPATRNNVKGRLSKIVKKEPLNLSKNNKNKKVDSNLNEEISLLKIRYDKCKRLSEKKKIQVQLNRLEKRSIDTVKENCIETLKLNEVFDNNLKKGFDLEKDEPMEIDICQKIHRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2W1</accession>
    <name>A0A0N5C2W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-catulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2W1"/>
    <dbReference type="STRING" id="174720.A0A0N5C2W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001231800.1">
        <property type="protein sequence ID" value="SPAL_0001231800.1"/>
        <property type="gene ID" value="SPAL_0001231800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="915"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001231800.1"/>
        </source>
    </evidence>
    <sequence length="972" mass="108592" checksum="80E45ECD6CE2F079" modified="2015-12-09" version="1">MNINNRIPDNTLETTFDPQNLEIKTKSIEQTLVPLVTQITALVNFKENIISNGKPKSERAIRGALKVGSAVEAAIERFVAVGETIADENPDIQPEMYDACREARYAGSSIANLNGSIFLEESSSGSSGAVDKAVLVKAARQLLSSVTRVLLLADRVLVKHILRAEDKVAFSLTKLENCSNFTEFVKIFTEFGGEMVDLAHRSGDRQNDLKSDKRRAQMSCGRTSLERLTMLLLTASKTLLRHPDDQGAKQCRDGVFHYLRLNLQLIGLCVTDGVMPYDISRYYTPLSFPSDEPLDIGLQLTASVAIKQLNEMLEMVRLTGSANVGIRERLIGALDQLCEMTQDFTDSPITPHHQREQILDYLEECRFEMSNLIAPAPIEDKDGLCNDNTEVSVERLNRRLGDLKKQLQAVALEQVAAIFRENEDHNILTSIKACSVSGDIDGVEKFLQKFKNHAEHVQDICRLLHHVSLTDSLHVYSGQTERTLRALSPLTLFAGRTLCIHPSSRIARENLEVFCDTWAQNISDLSRLAREFDTVASGRVAAEKQAYMSLPRPGVGYFETSCNYYPSTSMSSNLNMCNNFPFESYISNTSSSSFYSEQSPEISVSVTGDSAFISMPHSCLSSTATECSSDLSKSYSNSIQNSTHHLPDVLLKEKPNTCVSDNCKHIEFSLLKEHDCSKSAFTIFKKHQQDSISPLLLSPIMGEVSSKVSFSDENKEENDDKKLNEQSFPIKKHGTTTKPSKPITLDVEDQQKIAKVGLEMKLLTSEVDAEAEKWDEYAENDIVKRAKAMSSMAYNMYLFTRGDGPLKTTHDLFTQAEFFAEQANKMYKTVKEFHFEVPGSPEKSDLVSVLERIPLHCQQLQVLVKSPTVGKSATFGKVDSVIQETKNLMNEIAKLVTSCFVCATKFEIEFRGTGSTRSTANECDSSHHRMSRESTLWRRTPSTRRTAPPPNIHHHSSHDLQSTAISDKYQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4D2</accession>
    <name>A0A0N5C4D2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">B-cell receptor CD22</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4D2"/>
    <dbReference type="STRING" id="174720.A0A0N5C4D2"/>
    <dbReference type="WBParaSite" id="SPAL_0001281300.1">
        <property type="protein sequence ID" value="SPAL_0001281300.1"/>
        <property type="gene ID" value="SPAL_0001281300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056069">
        <property type="entry name" value="DUF7652"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24665">
        <property type="entry name" value="DUF7652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="110"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="294"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="385"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="502"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001281300.1"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116676" checksum="37064696609D19D9" modified="2015-12-09" version="1">MIYKLPPGDATITSQPTKPIKENELVTFHCEVHGGNPEPEISWLFDNSTEVPSKWYRATSNKETHISSLQFPAAANHHKAYPICRVTNKAMKEGTYKSVNARPLDVLHSPIVKIEPSNIYNVEEGKNVIVTCSADGNPMPTSYEWRNLGTGEHFTGGRVWSFVAEKGHSGELQCTAKNSIGYGSKTTTLNVQYAPIVEVKNFINPSENDEVHLECNVDSNPPSTRIIWTGPNNFIQEGSKLFIDKILSEQTGNYTCTASNTLTVTNSMFGSSGESTQREGSGTTFIEVKRKPGPATVITQTTSYPVGSSFILTCSTNDIGSPFANYKWATPRTSGKYVGDILYNDAILKVENTKLTDNGIYKCVAYNNLGEGVEGKIKLTIVSPPKITKSLPITRHLSTDDTKVSFECETIGYPTPSISWYINGNPINTDSILENYWMVNNKVVKRESSDCTACPSILQSILSLNHPITWLDKGNYSCIATNGPDDISMSALSNTIVTVQHPSIIVSKKYPIHGLSAANLNEPATISCIVSARPEPRFVWYKNGEELKNGLSQRYTIKTQQLPKKIDEYESILNIKNINEEDYGEYTCKANNGRNIDEQVSHKIILQKKSIPQVPKDVRLLSISSNSLYVGWVPGFDGGDKQIFNLQYIRIDPKTRNGVIPPKVIEINPSNVEMMDFYAIDDTNIFSGLRIKRGISSISNKKLRIVSYMVYNITNLLPMSTYMIGVSSQNAFGKSDWSSMIQGQTLETKIHSLNVHIQSMKYILEEQKLTFHTTPLSSPKNYCLMVYANDESNFNASDPKSQYFDSWHTIDCYPLDQSIPNIPPSRYFRTRICLRDNFSSCSPSSHVIMSNNHRTFEILILILGILVVLCCIVGFIGFCCTCIGRNKITKVKNNDTKKKIQHLVNQRSSNSTDEEILSKIKSGSSIEPSFTPLSTTPDSKIHSIDIHEIAKHYDNSYHSNQTIEQTQFVMLPSPSPLIEQEYQIGYTRLIDDYLNSQNGMRLPTTGSTDSQKSNIGGHSPTESTDENDGGSYSTTGGSQRVMREIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4Q0</accession>
    <name>A0A0N5C4Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0001293100.1">
        <property type="protein sequence ID" value="SPAL_0001293100.1"/>
        <property type="gene ID" value="SPAL_0001293100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895452" evidence="2">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001293100.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48302" checksum="E299B7F69A8AF0A0" modified="2015-12-09" version="1">MIFWRVVVFFLLITNILIYASVPTITLHDGHITLNDYLLKKDYHGTIIPGQPYTIDIYLSQSQHYDYVIESCVYNNKTTFISNNGCIIADEVFVDKWETTDYGYPNSLKRTLIHFIAPEPTLYIHCLLRLIECCSCAEKSCENPNGYNYYPYTPYQLIMSIPKITISPSASPSILGGFNAPAFTSLMPQRLPVEKSDTSIWNQWWIWLTIILAILLLFCLPCLLAIFFLWKKRQEDKNKDKIISKDKNGDIETNGKNEMNDQVQKKILDTKKNTKTFHTNGHQHVHLPTNLDIYKLERDSLFSHSSDSFVNDEFETTMSQTKSAKIISNPHSTLPFHRLPVDVPENIIHEVKDHLRTTEPIRITKPYYKESQNFSEQMLKKSTYISPPIQQRQYQDMLRRSNDTIGVSKTHESVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C549</accession>
    <name>A0A0N5C549_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C549"/>
    <dbReference type="STRING" id="174720.A0A0N5C549"/>
    <dbReference type="WBParaSite" id="SPAL_0001307800.1">
        <property type="protein sequence ID" value="SPAL_0001307800.1"/>
        <property type="gene ID" value="SPAL_0001307800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="348"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001307800.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55314" checksum="99D61D5DAAD9FFC9" modified="2015-12-09" version="1">MLLFISMTVRRSIDNSQPLMELFYVTPHNCIDQCVSLTGNNQDENSDCKSIVYNHYQHSCRLYNHDGNTPPAIIHPANGYDYFRRTAFSGPCTPTTAYDLNSHGILNNENYNSQTAAQFNELQKRQPLQRPKFSKKTDTNNKEPLTIVAASSPILNSNSPLPINIQSKTETKVQDDLITPQQAKAFKSNEPRPGSTGGVFKSLSDDVNLPPNSAKELGYTSSNEKSKEILMEKMNMLKSSEKIDKKCSTTIGYYVVIGNQVILPMQSNTKDVITFQGIEQSKCGKICSLGEGPNGEKITCNSINYFPISKTCEIYSILAEPHGTGSLIENDDVIYSEKFCLPPSSIVCQDDEIFILHVQKNLNSNIISTSSANSITSCLSLCLNDKNCKASTFDSDKSLCKLSSTNIGENIDELKDGEPGTVVIENGCTMRKRRSKLRGSKVFSNESKESHEIPIQSDLQWTEWSDCRYKIAGRNVRIRTRHCDINCADGGLQLEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5D6</accession>
    <name>A0A0N5C5D6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5D6"/>
    <dbReference type="WBParaSite" id="SPAL_0001316500.1">
        <property type="protein sequence ID" value="SPAL_0001316500.1"/>
        <property type="gene ID" value="SPAL_0001316500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895485" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001316500.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="10043" checksum="E09A4A62DC0A9023" modified="2015-12-09" version="1">MKSSIFFLFFLCFINNCLFEFRLTDYNQLQDKNAENYYENNFKQKEYINNDEFKNEESNSRTTEKPKCIYCKKLRDFEGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5M0</accession>
    <name>A0A0N5C5M0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5M0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5M0"/>
    <dbReference type="WBParaSite" id="SPAL_0001324700.1">
        <property type="protein sequence ID" value="SPAL_0001324700.1"/>
        <property type="gene ID" value="SPAL_0001324700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001324700.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55157" checksum="B97865C2FF30FE97" modified="2015-12-09" version="1">MNLFENTSTITTNSPISETWDRYSDDLGSDIFYDNQDSVQKIENEFYYDTEVIVIGNGPAGIALSAFLSGIQPYYNGSPEHPNTLLHQKLLDGKEEVNLLYQDIDWFETEFQNLIKPGTTPEASFYDVLNNSPNDNESCLKVKINQNAYTPHMVIGLGEIGGSWNTYDDEMVSLSFGNGMDLPGYSLKDYLNCSHTNVRLQARIVRDYFQNYVKKMELDKNFTNNTKVIGIEKLCDTASKTQFWNITCLKDDTLIPYNLTCKKVVLAIGKNVIQKLDLNGVYNENKIIYELRDLKGKIEYLRKGCQWNDNFNNSIKVIVVGDGYGAADVISYCLSMGIYIIHIIKRDKLQMKNHKLSSISDSIYPEYSSIYRLMMGRINNPYYVRYLRSSISEIYDDEVVIETGQGKINENYTFIVPCIGKKVDDTLKLQNFNISQTYRNRFDPTIFGIGSLIGDHYVRECVGGALAVARMIINKNSLSHHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5T2</accession>
    <name>A0A0N5C5T2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="SPAL_0001330900.1">
        <property type="protein sequence ID" value="SPAL_0001330900.1"/>
        <property type="gene ID" value="SPAL_0001330900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001330900.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20892" checksum="318F7420FD1F079A" modified="2015-12-09" version="1">XFTIAQAILDAFDTKTINHNYDNFDSEEGRKSVISEDSMNHMIAISTCFTQEWFKQRETINHRDVDNILTTDRKIADNAGLKIAYKAYRNFVRSFGKEYIVVPGFEQYTEDQLFFIGFGRHFCEYTSEDSYVPHNGKPGDILSEIRTNSILKNYHEFSNTFYCSYKNKLMHTKTCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5W0</accession>
    <name>A0A0N5C5W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5W0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5W0"/>
    <dbReference type="WBParaSite" id="SPAL_0001333600.1">
        <property type="protein sequence ID" value="SPAL_0001333600.1"/>
        <property type="gene ID" value="SPAL_0001333600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001333600.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="57227" checksum="A0DA64617A2EA5EE" modified="2015-12-09" version="1">MIGIILLIIILLYLINFYKKVKSLPPGPLPLPILGNFLICDFKNIHNWLYKLKYTYGNVYTIWLPLPRVVLADYDSINEALLTNGDNFLGRNANTYPDKAFHDKPNVGVVFSEGEEWRDQRRLSLHILRDFGMSRTIIQDKIHLVVHDIYDQIDSLENKDYVKLDKLLQLSVGNVINQILFGIMYCNAEDNEFFKFVKALEDFTKATMTWEFNLLVLFPFIDKIPILNSYLYGRITRTQKNMRDLSRIQVEKSKETYSPDDEPHNFIHAVMKEIQSIDSKYSYLNSDHLEGMVLDFWFAGVETSVTTLKWLILIILKHLDIQEKLQYEIDRVIGKDRLVQLSDKPNMPYMNAFINEGQRYSNIIPFSPERKCTKDTIINRHLIPKDTIVTPFYWGANADEKYFKDPFTFNINRFLDSEGNFKIEHEHLSFGKGKRMCAGRSLAEAEIFLIFTSLLQKYRFTHPNGPVDLIPNFIGFLQPKPYTCKIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6D4</accession>
    <name>A0A0N5C6D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase_GDSL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6D4"/>
    <dbReference type="STRING" id="174720.A0A0N5C6D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001350400.1">
        <property type="protein sequence ID" value="SPAL_0001350400.1"/>
        <property type="gene ID" value="SPAL_0001350400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF23">
        <property type="entry name" value="LIPASE_GDSL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001350400.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56716" checksum="99963E2478BE5086" modified="2015-12-09" version="1">MFMIMKNIYKKLFYHIVFIIIIINIVNTNLQNGDDGYVDGYLENDNVKKEEKKDERNFFDRIKDGILKQFDDDSEDYDDENLENGRASLLIKKTFDDGGTFNCQKVKKDYYTGYKAEKINPEDIDIVAAMGDSLSTGMGLWQNLKIEFRGAVFTVGGDSYLEGLVTIPAILQLFNQNLMGESHGMGDVDHLPLHQFNVAVSGSQTDHLEDQANKLVSRLYKVFDKHDLENKWILIFITIGSEEICYHCDPPSMSHVRKAVKILRKQLPKMLVVLIGPLYMAPTIRPNYNILKSRCSCLKKMSDIEYENLQRKWINSFDTLERDVAKLKFKNFGLISIPRLELISANPEYFLLKGQPLLNRRGHSYAAKWLWNRLIAGKSYNMTFRSAEKDSYYCPPMECPYFKVLDNEIECSVETISDHEEHIEEAKRRNKIFDGNETLDSWHQLRPLTRTQKMLKNNLLIIIPAIVLICLLIVVSIGRYVYINQSVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6X9</accession>
    <name>A0A0N5C6X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6X9"/>
    <dbReference type="WBParaSite" id="SPAL_0001369400.1">
        <property type="protein sequence ID" value="SPAL_0001369400.1"/>
        <property type="gene ID" value="SPAL_0001369400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001369400.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="38004" checksum="B63947A63BF1CA3B" modified="2015-12-09" version="1">MDEPKGDFLSLPVVFKLQIFERLHWKDINCLQLVCKDFYLKVVENRERLDREEVNYLKVYYTENKILKVDYKTMCPVLGLEGIVSRCIEFSNNYEYDYFFRNKKITDMKELVFENTINGEIINLTNIGYHMDFTLDNYYSFEISLSNGEFFSSPLRRFEISTTEEIAIPYNGTILKKEFHRKISLFERNGSLLVMKKIAMDIITGDPLMEYENTSSAIAEPIFTSIANHLSELRFFKFENRCGGERLRLFFYGADKFDVLEKIFYRKFFNKINYGDELMVNNRETNYSITNSTNCPECDTQHENRICLKEFGGYRTFDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8X0</accession>
    <name>A0A0N5C8X0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8X0"/>
    <dbReference type="WBParaSite" id="SPAL_0001435400.1">
        <property type="protein sequence ID" value="SPAL_0001435400.1"/>
        <property type="gene ID" value="SPAL_0001435400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="366"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001435400.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57732" checksum="CA82DFF7324483A7" modified="2015-12-09" version="1">MRGSSYTLNYSIEWLGSFPISKASLENVAKKLDSFILAQNNESLPVQLTISLLGVKVTKASDYKVIALQHSLRRICCVVGRPEVLQVAYITRETHDRKHRRVCHVFQTSTVEQALEIESILSKAFQAIALFNSQIPQYSKQSDEIVSGIISAPRCNINLNPALEETIISANGDVSAATLFKQPYNCSQSRSSRYTTSTQGQFNFDQIKDSKFTPFKENNVTSITPSSIKPQRQLSTVKIFTKFFGGTSSGNNIQGGNEKASKTEDSETPLRPPVLKRKSNKRLFSSIARSISGTKKTKTSTVSEVMANFYRKNNEKGEKIEDGNESFDPYTLKPEILGELVYNEKIDEMVYPITEYLDKRLKATRYFVVNRSKKSIEKALQIRSIGAFLITYSSSVKHCLTISIHTGFLDDNISSLVRHYVIIRNEKGFKIRGSSRHHDTIPTLVTYHSVDKEILPVPLVFLDWPDELLKKGSPKKNKSITSTPISCIRESEQYDNYKSFKMTKSCLKPVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C906</accession>
    <name>A0A0N5C906_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C906"/>
    <dbReference type="STRING" id="174720.A0A0N5C906"/>
    <dbReference type="WBParaSite" id="SPAL_0001438900.1">
        <property type="protein sequence ID" value="SPAL_0001438900.1"/>
        <property type="gene ID" value="SPAL_0001438900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="212"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001438900.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36258" checksum="383E504A8D0FF637" modified="2015-12-09" version="1">MTQVESKAPHFPQQPLAKQNEDGSLELECYVEAYPEPNLKWTYNNTEIKDDQRYQTCIDRESSNKFIARLKIKELNDDDAGAYRCCLTNGLGKGNANFNLKLTGFSSPTFVSKPAINSRDNGRVMVMEFVCKSVLKPTFTWFKGETKIFEDKEQHYKFVEEALSGNQYRIALEITDPKKEKDAGNFVCIADNNSGKLTATFSVKFEVPAGAPTFTRKPQISQKTSETNGEPAIVFDIGYCADGESEVSWINPNGRKIKEGNRIGIQNVKDSGNGNYTALLELRNYKAKDSGTYICNIKNDCGEANVELTLNIEGPSDDGADDGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9T6</accession>
    <name>A0A0N5C9T6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuroglian</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9T6"/>
    <dbReference type="STRING" id="174720.A0A0N5C9T6"/>
    <dbReference type="WBParaSite" id="SPAL_0001466500.1">
        <property type="protein sequence ID" value="SPAL_0001466500.1"/>
        <property type="gene ID" value="SPAL_0001466500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895830" evidence="6">
        <location>
            <begin position="21"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1134"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="144"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="243"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="341"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="438"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="530"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="624"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="729"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="831"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="928"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001466500.1"/>
        </source>
    </evidence>
    <sequence length="1207" mass="138413" checksum="DE64F85FF37A2C84" modified="2015-12-09" version="1">MVLFIEIEFLVVTIVLLIKAPSVPTSKLSLPPKLELQPPEEVWFQKSFVDYNTSDSRIPINRITLYCHGSNEPDFFEWKKDGKVLNIDGKHIQWQKEKQSGTIIINDPTSEDEGYYQCSMSNFFGTALTNKVHVVMGVLDHFVPSNIRQIVVNEGDSLTIPCNVPYGNPKPSIFWLYRDAKLNSVIETIRRKHITVDSDGRLHFSFVEPHDSRKNLIYQCAATSPVLHGEYRAGDEVQITVKPKVTTKPKPIHSLYLSPSENVIKVGGKLKLMCIFGGKPLPVITWKKRNEAGVWEDIKIDDANNGRSLVIENIRPSDSGHYRCSSQHIKHDMKVIVTTSPYWINEPPKDLNETEDSTGELTCDVSGFPQPIIRWYQNGSPIHNTDDDGRKMILDNGRRLRIYDLHHDTDTSVYQCNASNIYGYVYANAYINVAAHAPIFRMPTKRVWKVIQNSDVDMSCEIDAAPEANVKWVDEHDQPLQNIPGKLKILSNHTLRIMKINSADEGLYYCNVSNRYGINRASNKLEVFNPTYFTRVPSPKRLVVEANETIELFCGAIADPRLLVDYVWTHDGKPLQLPTTTDSNGVNRLKFDHVRGKDSGNIDCAAVTDVEVKVAGIELLVRDIPNPPIIQQFVCDDVAASINWKKPSENGDEIKKFIIQFSTSFMESNWTTAYEELNTERDHYFTKISLSPWVDYKFRIIAINSYGESEPGYPPKTECKTKPSRPYINPGNVMAEGNEPNNIVIYWDPIDKYDWNGPNMRYLIRYKINEPDNEWREFIIEDPLANYTIIRDQPTFKQYQVQVKSVNDFGDCIIEPDIVIGYSGENAPKEPVSGLKVQNIYNYSSVEISWDPYLIDNVRGHFKGYKIVYWNIEKPDQKTEISVSNRRTNYIINDLKAITSYNVSVKISNKHYDSAESEIISFYTPEGIPSKVHNFKARAVGFSSVLLTWETPLHTNGRIRGYFITIQQSFDGEIEETYVLYRQTYYLHEHLLPDTLYKVAVWAETYGGEGPKIIRPIKTFPLSDPDMPDFELTNKGLGYVEVTWKHSNKSYWGMSGSSFSVEYTNDQDDEWKQSISISLPHDTVHLENLEEDIEYYVVGISRDGDRVKKSLPKTIRTRGRSRLSHINRENLQKAMWFIAVLIALFMSLFTLCCLCYITQKRSGIYSVKKREIEKGHTMLSESEYAKFLECQFGVEQRSNSMQKVIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA19</accession>
    <name>A0A0N5CA19_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA19"/>
    <dbReference type="STRING" id="174720.A0A0N5CA19"/>
    <dbReference type="WBParaSite" id="SPAL_0001474400.1">
        <property type="protein sequence ID" value="SPAL_0001474400.1"/>
        <property type="gene ID" value="SPAL_0001474400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="217"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001474400.1"/>
        </source>
    </evidence>
    <sequence length="1257" mass="146417" checksum="7382EE8395C20ABD" modified="2015-12-09" version="1">MDTNRKCNVSKDWLLNYTNCNTGMIKKAMENSLLTNETVEFKKKMDRLKGIDFKIFNKNSTIHAEKRRESWRNSSKSSLGKSFMAIEKLNDCSDIQMNNGSEKISSSDCNKDDISHNMGKFEKIFHSLLYFYIILLVKNSSFNSKLEGAHTILRVMTSKEMRGNIGSQETNKHCKERDGFLRKNEIVEKSLHNHNFISMDLESNLKVIDCCPNERYYQFNEQIGKGSYKNVYKGYDKSSKIYVAWCETNYAHLKIRGIEKIREEIYLLSLLSHENILPLLSYWEYKIKGVKGTNVVMITEYFDAGSLKNHIRTLDCVPKGCVKTWGRQILNGLSYLHNHNPPIIHRDLKCDNILYDKKCDILKICDLGYAIFKGNFNNEGVIGTPEFMAPEMFSEQYDEGVDIYAFGMCLLEMVTGEYPYQECRKPNDLYNLVTNNVKPLCLSKISNIYSDIKMIIERCIRNRRNERWNVDELLEDELFTDFNKFEVKIKSSCYKEYLQRDSPLFTLEIIGNTKKLKTKDFELTSSIFTFDCEREKHFDVANRLIEDFHISVKFKDQLIEQLERYVKTRKRFIKYREIEFENEEKYSKEKMTEDGENRIILKNLNNNALVESVVPVSFTRFLQILKEWNITDKLTSDRNPPFIAVKVLEHFNISKKTFRLLFMNKKRQTVVITCVHSCIPERIVKQLVYHNIIDKDCKEKMMFILIDISNKINDISLNLLPIKLLFFLGNTSVKKEKKRYTKNLKYPLNKKNTSLESIDENDHFQETSFTQHINKQLDKDISKDWDVRIEGTLNVPINELKDNIFKDNGNFSLENGTLSMLLKYFTPNVFASNAFSVYFERDNISHFIKSNHFETFFNVYTKDFDKYIRKCHCLGHITIIEIENKIKSYFSTIELTQKRALMMKKSLTYSGSSNGNNNMNNDNIINNNIRKVFNKRGSKKSFQISKVCLDDVAKENDPKILTRKRSITIALPTIVDSSRQSEIINMMNIEESLKTFNDKMILHDKKNNNCTKGIRRKSSSYEDLFNYEKRGEEYFSKRQISFDNNIMNYLKNKTFSDGTLENVSIDKNVDKATSGDDKRLCDNLIKKKEPLSSIDLKSIECSDTQSDTIDFVKAKDNVEILNVISVDKPKERPVNGGKLHKGPSLCDDLEDDNCYEVKCTIARNKHFYKADSLKNDCNFVDDGSIEKKKKVSELSKQLAELINNGFEHQSPPLSEISVKNDLVNGNITNNGNSIMRLDTDNGKILTEEEIKQNIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA58</accession>
    <name>A0A0N5CA58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA58"/>
    <dbReference type="WBParaSite" id="SPAL_0001478300.1">
        <property type="protein sequence ID" value="SPAL_0001478300.1"/>
        <property type="gene ID" value="SPAL_0001478300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161270">
        <property type="entry name" value="PspA lactotransferrin-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001478300.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12376" checksum="E9B1025AD98BF936" modified="2015-12-09" version="1">MEENSEAIIRRSLMTNSDQSLISKSFGDDNESVFKRQAKKRKRPAPPKRRRRKRKQKKKQQQLKDKIKDLQNQIDSITGNLNNNQNDNTEGDIYYYEDDAKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAQ5</accession>
    <name>A0A0N5CAQ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAQ5"/>
    <dbReference type="STRING" id="174720.A0A0N5CAQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001497500.1">
        <property type="protein sequence ID" value="SPAL_0001497500.1"/>
        <property type="gene ID" value="SPAL_0001497500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF45">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895681" evidence="5">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001497500.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45996" checksum="BF717B2D78A62631" modified="2015-12-09" version="1">MVLKLLLLLFLFILDITIAIVKVPIIVKSPLRHKLIREKKYTHYLLYREAISNYHSKKYVNDKYIQPVEDVQDMIYMANISIGTPPQYFKVVLDTGSANLWIPDSTCKYNLPEMRRSFVPIYKNLPECPSICNVVDYHSCPHLCDPGCCKKQYKKLLKNIFTLMNYQYSDDKNCKSKSQFDNNKSLTYIKNGTTFKIRYGTGSASGYQGSDIVCLTPTALCIPNQDFGQATQLAHILGLAFRSIAVNKITPPIINAYNLGLLEKPIFTVYMGHFGLKDEQKGGTFTYGGLDTDNCGDVIAYEMLTSPTYWQFNIKGVSFDLFSDTTTSTAISDTGSSLISGPKGIVDIIGDKVGATFNVTTQTWVIDCNYIGPPITIKIRDNSYEIPVVNYVPLIDGDSVNLDYFFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBE9</accession>
    <name>A0A0N5CBE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBE9"/>
    <dbReference type="STRING" id="174720.A0A0N5CBE9"/>
    <dbReference type="WBParaSite" id="SPAL_0001521400.1">
        <property type="protein sequence ID" value="SPAL_0001521400.1"/>
        <property type="gene ID" value="SPAL_0001521400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001521400.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11949" checksum="25328888830C6AE8" modified="2015-12-09" version="1">MDKFASNVIEKCLIDGDQEQVNTLVTKIFEVPFEDLLYRMIGDQFGNYVAQKMLDVCDVQSRKKLIAAIKLKQAFLKKLPFAKHILAKCSESQFSPQKDREASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBP2</accession>
    <name>A0A0N5CBP2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBP2"/>
    <dbReference type="WBParaSite" id="SPAL_0001530700.1">
        <property type="protein sequence ID" value="SPAL_0001530700.1"/>
        <property type="gene ID" value="SPAL_0001530700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001530700.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19122" checksum="B47AACD264AB7622" modified="2015-12-09" version="1">MKDINSALKEMLEYENNMKDINSALKEMLEYEIESVARKCPICNKISSNMTKKRIIKKYPKYLFVELTKNIMDKEHQNMGIDFISSKDSVYVNEFFTPNTPYKLKGFIAYERFGRRTGHYVTYVRYEDKWHCLNDSQKPKEIDENELPTERSTVLLYEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBQ8</accession>
    <name>A0A0N5CBQ8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neurabin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Neurabin-I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neural tissue-specific F-actin-binding protein I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein phosphatase 1 regulatory subunit 9A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBQ8"/>
    <dbReference type="STRING" id="174720.A0A0N5CBQ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001532200.1">
        <property type="protein sequence ID" value="SPAL_0001532200.1"/>
        <property type="gene ID" value="SPAL_0001532200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000010">
        <property type="entry name" value="Neurabin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000008">
        <property type="entry name" value="Neurabin-1 isoform 1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040645">
        <property type="entry name" value="Neurabin-1/2_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043446">
        <property type="entry name" value="Neurabin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154">
        <property type="entry name" value="NEURABIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154:SF6">
        <property type="entry name" value="SPINOPHILIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17817">
        <property type="entry name" value="PDZ_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="423"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="18">
        <location>
            <begin position="926"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="525"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="710"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="833"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1001"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="624"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="833"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001532200.1"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115490" checksum="FB5D84A99CE126EE" modified="2015-12-09" version="1">MTTPEIINGSEDVRTRFSHSKALFQQLEKERMDHLPSFYSPRPSRHIVLRGHNNINDGVVMTSTINKTNMIKGGDKQNFINISNGTIKNSTNINNSYQDCGKEMSPVSTSSSITASSTASSINSSSTTTTTPLNMINPTNNINNSTNNTYISPVAAIAAKFNNPQMSNFKNNIPPPVPPKPSTNNCITSSVYQQRSNTSSPTSPIVSQVEENFNQLASELDKINNISNYNSYSSTTTQSIDTMPSKNIPTNDNDKNASFEPYWRDPSYYKKRYGMDNNCIENSNGKKMDKNITSPHTSTASSTNISSPSDSESGDSLINEINNDNINNSLSSSTKKGTTFALIRSKFDSGAFSNGNQCSSDNEDEIDPECEEKKKVKFSTNPIEVYSAYAAEDYDRRNEDVDPVAACAEYELERRLEKMDLFDVELEKGPEGLGVSIIGMGVGADSGLEKLGIFVKSITPGGAVHKNGEIQPCDQIVSVDGISLVGVSQMFAAETLRSTGKRVIFTIGREKNLDDSEVAQLIQQSLEQDRSRQPSYYNNTTTSSSTTSNNTNSPSPTVPKNNNNINNNYSQKSIGSVVTPHSESTTSVFSKSFMDDTEIKSRISALEVELNDSQRRTEKMVEILETSRNHCKLLEQKYDQARQLLENYQNREKELLEREESHIAQLRSKDNQYSLLIDQLKTRIDELERKMSTPSQQNIYTTSDYNSLLRKKDSTDNESQISTFLDNKDKKSPPNTIKSNTNTLEKELPKVVPRIYPRTTPNMSSSLYNNGTPGSGHAFMLQQNNSTLNNNNVTNKAMSQSVYADGTETSNSKRNTIRRNSEVEEKCYTPTIMSTNKTTSYPNNISSNNNTGPYNSHNSLLSPLPRTANSSPQPRISEPVSPATSTKFLQNQRRILFPLRKRFAMHTECEFWRPSSVEQGLQVLSWTVDDICQLLIQIGLDKYIPEFTINEINGPKFLELDGTKLKNIGVSNHSDRAIIKKKIKSIKNKIEKERKALEKLSRQRAVAISNNSNPPQITDVMSPPPPSNRSISPGSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCJ9</accession>
    <name>A0A0N5CCJ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001560500.1">
        <property type="protein sequence ID" value="SPAL_0001560500.1"/>
        <property type="gene ID" value="SPAL_0001560500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF877">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733556" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001560500.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="45434" checksum="A579347FE389528F" modified="2015-12-09" version="1">MLLITLFYLSFNFIIASELNNFFQSNVTLNQREKRAVIRNQKFKWKSHIFPYYISRDLNLNYSIIIVALVKIEKSTCLRFSRVFNKKRASLIYNAGPMYSTHLGKEGDFPQKIFVPRGDMHHGKIARETLRALGFDYEHNRPDRDIYISIIKNNILARYLPLYAKKSPKAVNTYGLSYDYRSIMHYGSKELCHYSTQCIKSKNKDPLVDLAMGKTTDLSFNDAKLVNLAYCISLILIRKSRCLNYGFPLGLAKTRCYCLPYFEGKKCQRFTTNFEYCTNPNVFYANERITKVTLKARRDCYYFIKAREGKQIMLYIEFSRFALNTHVCNENQHLEIRFKKDFSVTGKLVCPLASYYSFKSESNMIIIHSKYDIKYYEFTIYYHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU6</accession>
    <name>A0A0N5CCU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU6"/>
    <dbReference type="STRING" id="174720.A0A0N5CCU6"/>
    <dbReference type="WBParaSite" id="SPAL_0001569600.1">
        <property type="protein sequence ID" value="SPAL_0001569600.1"/>
        <property type="gene ID" value="SPAL_0001569600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="148"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569600.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41792" checksum="0E7DA214E8147C5E" modified="2015-12-09" version="1">MVAKKCRVCTDTCSFPRNGSKSVKKCYEKKQCKENKNYACVCKSGYYLNDKNKCVKRKDCNKDQGTTKKPTTTTDKCKKNEIWKSCRSACEPNCEDASRAPKPCVKMCRPPGCECQPNYVRNDETNECVKPSQCPKTTTPLPPTTGKCKKNEHFTLCGSACEPRCSNYDKKKNWCNFQCLIGCQCRNGFVRNDYTNECIPSSECPVITTLRPPTQQCDVNSTFTMCTSPCQDVCSKAPIKVCTRNCGPPGCECLRNYVKNDVGGDGKCILRKDCPVATTSRPGTTPRCPKNMIYTNCKSACPSRCEIPRNVTSVCTFECAGEGCECREPFALDESNNCVRREECKKPSKGGYYIIHMLRKTVTTMYTLIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCV9</accession>
    <name>A0A0N5CCV9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCV9"/>
    <dbReference type="WBParaSite" id="SPAL_0001570900.1">
        <property type="protein sequence ID" value="SPAL_0001570900.1"/>
        <property type="gene ID" value="SPAL_0001570900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001570900.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="41321" checksum="A514939037A9DAD0" modified="2015-12-09" version="1">MDSNTDEKRSETENYIFILPDVLLVRILSELSWKDILNVRAVSRSFYNFIYENYYQLNRREVYQVRIFYAKDFESCPFELDLKFDSIRNYKSTNSNSWVKSIGIQSDEKLSSLLKIFDMRNLEYLSMEVDCNIDIFGIINRSFQEGTKIEDLIIYGLSEKNLTSFKTFIDKLLLVEDFSILNICYHSTESKDVNPLSFIQSLNITRSFLLYECNETRILSTDMVNNFLRRNPSVERFTIGSGNSEFMRNLFKEHFMLEQPHTIDNNLSCKKLRIRLEFYVSEYKQLSNILENDLYERENVQEVISIQNFPEYSKIESVIYCRHCPKDKHKIEIDATLEGVYLNTCDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD22</accession>
    <name>A0A0N5CD22_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein ZPR1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD22"/>
    <dbReference type="STRING" id="174720.A0A0N5CD22"/>
    <dbReference type="WBParaSite" id="SPAL_0001576900.1">
        <property type="protein sequence ID" value="SPAL_0001576900.1"/>
        <property type="gene ID" value="SPAL_0001576900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="245"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001576900.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51944" checksum="257EF4FB5F7D33C3" modified="2015-12-09" version="1">MSNNEDNVVFKDLSADDDEQMPFEIESFCFNCHKNGVTKLMCTRIPFYKQVIVMSFRCEHCGFSNNEIQSGEKVQEFGTEIVLKVKKAIDLNRQVVKSEFAQIEIPELDLEIPPKSQPGEITTVEGILARVREGLEQNQVQRKIEHPDDAKKIDEFIERLENLRQLKTEWTLKLKDVSGNCFIQNPDPFHVDPRCIISHYYRNLADRKILGFADDDDEEDDISKDPDTQWKSFEDVKQEVLHFPSKCPNCNKMIETLMKPTDIPYFQTVIIMSTKCDDCGYKSNEVKSGGAFQDYGCKLSLKVKNQIDLARDVLKSDTCSLTIPELDLEVGMGALCGRFTTIEGLIVATKEQLEEQGRFLIGDSATNDAKGKFGELVGKFDDVLNLKLPVTIILDDPAGNSYIQSVTAPIDDPQLEKTFYTRSYEQNEELGLNDIKTENYDNNTSDKMEAIAEEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD93</accession>
    <name>A0A0N5CD93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD93"/>
    <dbReference type="STRING" id="174720.A0A0N5CD93"/>
    <dbReference type="WBParaSite" id="SPAL_0001583800.1">
        <property type="protein sequence ID" value="SPAL_0001583800.1"/>
        <property type="gene ID" value="SPAL_0001583800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002603">
        <property type="entry name" value="ET_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01684">
        <property type="entry name" value="ET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895761" evidence="1">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001583800.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38143" checksum="FEA4A3F881F45045" modified="2015-12-09" version="1">MLLLLFLLMNSFFFTTNQLECFIGVALGSHAQDVTGSVMPCSGMCSNVTLAIHNTVATIFTCDPFDVCATIEIDNECTFQWLDISMCCCSNENYCNVKNWIMAKAVSQSPDSFTESPLPSDIPPQETIECYVGIDFYERMRIENYLDSNNFSILLKKYIFMLLTNFNMPKNSENLNIFLQQHILSIMLTVTNKNNNSNFILIDDYNENLGNNYNELIKPLQHLYNGQGLVIKMNCTGNCANTTLGDAGMVYFCDPEYFCMTHNLEDKCNDMDYLLISCCCSSPYCNMNHDNCDGDKSTLPTFFPIETTTSFSKLKSSNKINPFIIILFYIVLILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDJ6</accession>
    <name>A0A0N5CDJ6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDJ6"/>
    <dbReference type="STRING" id="174720.A0A0N5CDJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001594000.1">
        <property type="protein sequence ID" value="SPAL_0001594000.1"/>
        <property type="gene ID" value="SPAL_0001594000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1320.10:FF:000004">
        <property type="entry name" value="28S ribosomal protein S16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001594000.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17204" checksum="2BD57F50662E3AF7" modified="2015-12-09" version="1">MRQLVNPRLFGKPSIGLALFGCKNRPFYQICVFPDKKLGRRYEGNILEQVGSFDPLPNKNNEKLVALNFSRLKYWIGKREAHISVPVLELLGLSGLLPIHPKTYLRAKSNTEYLEKLRLEEEKRKKEELESEKQQKEEKEQEKEHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE97</accession>
    <name>A0A0N5CE97_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE97"/>
    <dbReference type="STRING" id="174720.A0A0N5CE97"/>
    <dbReference type="WBParaSite" id="SPAL_0001618700.1">
        <property type="protein sequence ID" value="SPAL_0001618700.1"/>
        <property type="gene ID" value="SPAL_0001618700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001618700.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32942" checksum="E01C2797AE3B2958" modified="2015-12-09" version="1">MGNDKGFDTKKFFLDLATGGTAAAVSKTAVAPIERVKLLLQVQDASDAIAKDKRYKGIVDVLVRVPKEQGLSALWRGNLANVIRYFPTQALNFAFKDTYKKLFLEGLDKKKDFWKFFAGNLASGGAAGATSLCFVYPLDFARTRLAADIGKGSTREFKGLADCLVKIAKSDGPIGLYRGFFVSVQGIIIYRAAYFGMFDTAKMVFAPDGKKLNFFAAWGIAQVVTVGSGILSYPWDTVRRRMMMQSGRKDILYKNTLDCALKIIKNEGMSAMFKGALSNVFRGTGGALVLAIYDEIQKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEJ2</accession>
    <name>A0A0N5CEJ2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5CEJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001628000.1">
        <property type="protein sequence ID" value="SPAL_0001628000.1"/>
        <property type="gene ID" value="SPAL_0001628000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000004">
        <property type="entry name" value="Small nuclear ribonucleoprotein-associated proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001628000.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20952" checksum="877678E23EDBFCFF" modified="2015-12-09" version="1">MTLGKNNKMMAHLNHRMRVIFQDSRVFIGYFKAFDKHMNIILVDCEEIRKIKAKNGQKSGDREEKRVLGLVLLRGEQIVSMNVDGPPAREDDALKFLRTAGARGGPGVANPAQRPMGMPGVVPQQPVPGLQGPVRGMGGPAPPIMQPQFIPPPMGQMPPGQIPPPGQMPPGQIPPGQMPPGQMPPVPPQNQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFC7</accession>
    <name>A0A0N5CFC7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFC7"/>
    <dbReference type="STRING" id="174720.A0A0N5CFC7"/>
    <dbReference type="ESTHER" id="strea-a0a0n5cfc7">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001656300.1">
        <property type="protein sequence ID" value="SPAL_0001656300.1"/>
        <property type="gene ID" value="SPAL_0001656300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="18"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001656300.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61943" checksum="F2593620C3DF7EE5" modified="2015-12-09" version="1">MGNSLDHLFKGKEVEGRRIETKYGPVIGKRIINDKDKEVDAFLGIPFAKPPIGELRFQKPVPPDSWTEPRRCFKFASRSIQKDMFFWQKYSLMDTSEDCLYLNVFAPVNGPSSDFPKGYPVMVFIHGGGFVCDSSVKYGDIGISKHLVSDKGVIVVTIQYRLGYLGFFSTGDDVCPGNNGLWDMTLALKWIQNNIPNFGGDKDNVTIFGQSAGGCAVELLALSPHSQHLFHKIIPMGGNSQCNWSLNKKVVEICYNFATKHGIFTRDSKDLLNELRNLPANKFGTSLQLSTSDISAIAKPTTEIGPRIDGDFLPESLEKLQKKSIPKPKIIGLCEAEGLIFQLFMKTHHVGKLEDIIATIIPETDFPNFKELRSKALKLYMSEDFDNKSKGLFNRQVGKFFSDLFVGIGTKLSILRCIESGVEPYVYIFEHFNPKQFGILSLKIPYKAATHCWDISYVVKVGIVVNWEFTKEDLIIVDYMTTFWANFAKYGNPNGINESNVPVQWEPATKDNPNRCLRIKLEPEMSETFFDNTSDFWLELDKYKNLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG84</accession>
    <name>A0A0N5CG84_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CG84"/>
    <dbReference type="WBParaSite" id="SPAL_0001686300.1">
        <property type="protein sequence ID" value="SPAL_0001686300.1"/>
        <property type="gene ID" value="SPAL_0001686300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001686300.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13018" checksum="DFD0EA7A82A662B4" modified="2015-12-09" version="1">XINSSLSGLKDIIQFGRTEFSESKPKRKEKVLSPGMFVMKRVLHKKLNHTFHKNRDIFEGPYKVIKHLHADTYIIQKCTRTGRLTGKEERVTTDRLKVVPSLSINYLINIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG91</accession>
    <name>A0A0N5CG91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG91"/>
    <dbReference type="WBParaSite" id="SPAL_0001687000.1">
        <property type="protein sequence ID" value="SPAL_0001687000.1"/>
        <property type="gene ID" value="SPAL_0001687000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001687000.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38946" checksum="4D9391B6AA8D334D" modified="2015-12-09" version="1">MKYNQKNYLDPINNWTKTEIIVSPGPNNILIGCTYLGITSFFIFIQIMTFITFYKKKNLMSNMPFRIMRHLGVSDIIQQSIHFTSAFYTIFLFSTNSIIVNCLASILQSAYITSVAFITLLTINRFDVFYQQPFLSFVNRKILFNCGIVICYICLILLIIFYMIPSFRLTFTLVNYGWLYQSKKNMWTPAWEVENKTVTFLLLLSFVLYVLIFCKIVYMRSATSSLSKIQFSDIRILAQGIFNFLSIVFLEWAWRYLPNIVGEQYTCATVLNYFFLFVSGNNTLSGLLLIKEIRNEIWNLIMCCFFKTPVKTSTSLKHFKRIINADVNIRHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGH7</accession>
    <name>A0A0N5CGH7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGH7"/>
    <dbReference type="WBParaSite" id="SPAL_0001695300.1">
        <property type="protein sequence ID" value="SPAL_0001695300.1"/>
        <property type="gene ID" value="SPAL_0001695300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895902" evidence="2">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001695300.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16972" checksum="DD52AEFEBE5518D9" modified="2015-12-09" version="1">MRFMKYLTILLLLAVQYSVQSSSSGSSSSSDEEQALSNEVQLANTETSNGENSMNALTDSTTLKGEKKKGLFKNVLSKKKLLEGTKKTKEGLKKATKKGKKLMGKMFNGLKSSLKKLSSKKEKSSSSSSSDSDSSEDQNDRQKRFLVIEKDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH69</accession>
    <name>A0A0N5CH69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH69"/>
    <dbReference type="WBParaSite" id="SPAL_0001719100.1">
        <property type="protein sequence ID" value="SPAL_0001719100.1"/>
        <property type="gene ID" value="SPAL_0001719100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895972" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001719100.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21988" checksum="7CA86BF84A2D236A" modified="2015-12-09" version="1">MNKLLCIILFVLLTQGSCQDGSALMSRGVTRWKNYVSEFFEDNQVVGLFELALDLIYEEKNISTIGSSLTDYLMNNLTLSQTSKIAGFGLGLPVYYSGGISGFLDVFTTHISTNLSPFCMQLQGEMIKMKGKGDEKQYIYNQGTYMALTMFTPAKIEGIFCRFKKKMTPAVWSKLYNSVVKYKILKVELYEANCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHA1</accession>
    <name>A0A0N5CHA1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHA1"/>
    <dbReference type="WBParaSite" id="SPAL_0001722000.1">
        <property type="protein sequence ID" value="SPAL_0001722000.1"/>
        <property type="gene ID" value="SPAL_0001722000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001722000.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11864" checksum="AF63C7A91F08C57F" modified="2015-12-09" version="1">MQVDSEYILVIVDEYSKFVVTSVCKKQNGPTLKLILMKCFSMLGFPKTLRSDNGSAFIAEYVTDYLASVNVEQQFSSPHNHTSNAIVERFNRTLRAAIRIRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHW4</accession>
    <name>A0A0N5CHW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHW4"/>
    <dbReference type="STRING" id="174720.A0A0N5CHW4"/>
    <dbReference type="WBParaSite" id="SPAL_0001742600.1">
        <property type="protein sequence ID" value="SPAL_0001742600.1"/>
        <property type="gene ID" value="SPAL_0001742600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF59">
        <property type="entry name" value="LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895893" evidence="9">
        <location>
            <begin position="26"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="10">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001742600.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66227" checksum="57DED597FF0ABCD0" modified="2015-12-09" version="1">MKHSLINAILIFIILFGKKKLFTRGFAVDIYDRDTLNEVKPNYCNNITLQKEHGLTKTTIGNFLGLHCSGEFYQCRYYSDGYKTYKKTCKAGLVFDTHGSQTCNYDYNVLGCGIRGSNVKMCNIDEFTCSLSEQCIKIGKRCDGKYDCILEEDEQNCPMCGKDEFQCVVSEECLPQSVRCNGITECGDGTDELNCDQCGRGNFFCRNSNQCIPEELRCDGTRQCSFGEDEYNCRKSKKNQKSYACEDGSEKIEIKYVCDGVPDCPDSSDEKYCEETTQSNIYHHTTNPRHYVEDVGNHLFTRGPLLPIAKIPLPVTTNNFYPEPQPILIESTKKPQLKIKKTRKITTTTTTIPPFTDSETSIDNQDYEDEKNEWDKDTSEVMNNQPKFSSNIPEFLGTKGRKSFFNNVFSTINPNVIENVMKSEITTNTINNDNDDLLKKLSLKLNSLGNQNEVSNLLSKLESLLSSPTTPYPDSYVSIKLPPKQSKVERRKEFVRITSNPLRKWQPSLSQNQIKLTSKNIMRDKPLLGTITTTTTRIPITTTPYPILNRIDVQLRQSDEPMIINSNEEKESVEYVDATTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI95</accession>
    <name>A0A0N5CI95_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease subunit S</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI95"/>
    <dbReference type="WBParaSite" id="SPAL_0001755200.1">
        <property type="protein sequence ID" value="SPAL_0001755200.1"/>
        <property type="gene ID" value="SPAL_0001755200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001755200.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13050" checksum="D46171FFCF5B9E7D" modified="2015-12-09" version="1">MNIFASFDVLQKKDYGVVPESTIQVLKESQVIPDGWKIMTVRIEGRNVVYVNGKKSPYFLAYYKAPFTMSGQTYESVHDVYQVAKLNELCGNEFARVYLSKRTIPKKRAFVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIX5</accession>
    <name>A0A0N5CIX5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIX5"/>
    <dbReference type="WBParaSite" id="SPAL_0001778000.1">
        <property type="protein sequence ID" value="SPAL_0001778000.1"/>
        <property type="gene ID" value="SPAL_0001778000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001778000.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9427" checksum="57FE1769C05A30A1" modified="2015-12-09" version="1">MRTFQVAAHNKIDVLDRVPQDELYAFFEGIKLRSSSNTCYCDSTMNAIDVPSTVTSNSHKTLEDLFDGYDNVSDKSSTNSLNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2F1</accession>
    <name>A0A0N5B2F1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2F1"/>
    <dbReference type="WBParaSite" id="SPAL_0000025800.1">
        <property type="protein sequence ID" value="SPAL_0000025800.1"/>
        <property type="gene ID" value="SPAL_0000025800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000025800.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30559" checksum="323212EACC652E96" modified="2015-12-09" version="1">MLSPIYYHDGIYTPYRNRSCDINITTPDTYNIDVAELKSKFEDPSISNENNRIRLMSKRRLNKIAAQKLLKSRGFLKDNDITYGALTLPDYNKSDCNLERNNNAIYEEKECLWTPIRHHPNVKVSNLIKNLENLEREGCLKTPSRYLKRAFEELRLNLTPISTPSSIDSSFNSEKEKDSKQRRGFKKSKISLIPVLKYRIPSRESIFRRSSLKKLCMVNDNKNKDSTETENCPTHVTKINEHTKLTKKSKIPKLFNKKKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2H0</accession>
    <name>A0A0N5B2H0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blood vessel epicardial substance</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2H0"/>
    <dbReference type="STRING" id="174720.A0A0N5B2H0"/>
    <dbReference type="WBParaSite" id="SPAL_0000027700.1">
        <property type="protein sequence ID" value="SPAL_0000027700.1"/>
        <property type="gene ID" value="SPAL_0000027700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000027700.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15536" checksum="6BEBEFDBE7B3E0F1" modified="2015-12-09" version="1">MAVAKQISTNLTDMLNKDLEAHCPVEVFPYSVFYVFYENYETIVSDAIIQIIFSITGIFVVATLCLGIDLWSGMIIVVTIASILLNLIGLMYWWNIDFNAISVVNLVMSMGISVGDHKKSSGDEFRHTVCLNSSVMSLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4X8</accession>
    <name>A0A0N5B4X8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000112800.1">
        <property type="protein sequence ID" value="SPAL_0000112800.1"/>
        <property type="gene ID" value="SPAL_0000112800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000112800.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51260" checksum="BAB8CE9531F9C8F1" modified="2015-12-09" version="1">MLHFNVXXXLNRWGLSQLKVIKFCYLKSVILASTHNFSVTSTPLSVLLEDQSYLQLTESFKSRAVTLFSTFQTLNPTISARNLVRLSVDAVCFIKESSDSTKTINICEHLLKAVENQLNLVQPTIIPPSPPPVTVGSQTTTLEMSTAWCTHTIFDIKKGESIEPWIDQLELLLEADGITQDARKKVALLAKLPVECRKFVRSKPAEEIANFDQIKTILINKYDGAISVQSAQQRFKSYKIDIEESKFYRSCIEFGKLISTIYGDLSESQLLELQLNFLQSKLTFNDDLWNKMNTRPAYNSYQECVRDLESTLRIVNDRKNKRKINTRNFKKNNSYVPNESKSREQFKSAYNVRKNFENHERNARVADNNLQTVDDTICAQQSRIITDRIGRLEPTVDNPSEEKDQFEIQVETLKQNLKLSSNHKCITRMAKIREEDEATVQIVKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4Y1</accession>
    <name>A0A0N5B4Y1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4Y1"/>
    <dbReference type="WBParaSite" id="SPAL_0000113000.1">
        <property type="protein sequence ID" value="SPAL_0000113000.1"/>
        <property type="gene ID" value="SPAL_0000113000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="116"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000113000.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="53059" checksum="3EE0A43F237EC69E" modified="2015-12-09" version="1">MNNSILSTKDNVSLLFETNDDNDWKKSNKSLNNLLYNKTMRTDVYNSLKTSLFVNKENNVTDNNYVAINSSDNKTMRTDVYNSLKTSLFVNKENNVTDNNYVAINSSDFQKTIKKRAIQSRKSHKWNFPIKYQINNNILRGAVASGLNFIMKETCIKFEEVDRVVGNGLIYQYGTVCASIVGRNPSGRPQEIYLSSNCINGPSVQHETFHALGLEHEMSRKDRDNYIKILRRNLHPSGYINFISEPFTKTYNLRYDYGSIMHYDRLSYGNGRALTIIPTNYHYLKTIGQNSEASFNDIKLLNLHYCNNSCFKKLNCLNYGYTHPKNCDECKCPTMYAGKFCQKIKRSSYNCPKQTLYAESWGQQLIVQGRKNCYFQILAQDDFRIKIHIESYNLHFQNVCQPNMGLEIKFLKDKSVSGVRFCEKGRNKIITSEKQLTLIQYVGYAPYHYVKIRYIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B553</accession>
    <name>A0A0N5B553_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="5">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B553"/>
    <dbReference type="STRING" id="174720.A0A0N5B553"/>
    <dbReference type="WBParaSite" id="SPAL_0000120000.1">
        <property type="protein sequence ID" value="SPAL_0000120000.1"/>
        <property type="gene ID" value="SPAL_0000120000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="19">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="18">
        <location>
            <begin position="463"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000120000.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62213" checksum="F4EE6176D3B7BD8B" modified="2015-12-09" version="1">MLKLVGTIQTCAPSFDVFFVLTHYGVFGFFIEITFLELLNSYISKEAFADPSALLIECYKNKRWFFILLVTQLVGGLISFQLARFWWSFNIHPTYLDMLVNTNCQSHLNVSIVNGMLIESLGVIGIYYITELINRKIKNPMIVNIFSAISVASICVSGLNLTGMYGNPIIAWSLCAISGGVDSSVSAYILKKKGFEVIGVYMNNWDLLEEGNSNCSRDKDKEDARYVCEKFGIKFYTLECVKTFWNEVFTNTLDNYVKGRTVVPDIMCNKLIKFDELHRFSKEKLDVDFVATGHYAQNSLGNFLEKIIYNNSKENSKLLRAVDPVKDQTYFLASLKEKQLRNSMFPIGNLTKNKVKEIANDIGLNRILEKDESMGMCFVGKRKNFSSFLNNYLESKIGNIVDIETNDILTQHNGIHNFTIGKKVRLPPSVFQCYEGLFVCKIDSNTNTVYVCRGSNHSSLYSKSFILHNITFINDNINDFSNIKCSIQRNHPPIQCQLKQIDKEFLQVDLNYHLKSVANGQFCVFYKENECLGGGEIFSSKILFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B616</accession>
    <name>A0A0N5B616_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B616"/>
    <dbReference type="WBParaSite" id="SPAL_0000150600.1">
        <property type="protein sequence ID" value="SPAL_0000150600.1"/>
        <property type="gene ID" value="SPAL_0000150600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000150600.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="41023" checksum="2BDD456327C46914" modified="2015-12-09" version="1">MEKYFEVFIKNIDLGIHSLLFCLLLTYSSKFKASQYSSILFHLLFGILTIIIPQIIHQPSITNGHLNKYHLYILRFDGAFHIGIGYYFYKVLKNEMKIDVSVYFSKFVVAICHLIFQLITAYHLYESRNDPKSKSLKPSQKYLHVTMMIYGMWAFAEFIKFVRYSNTDMDKIDEIKEKAESLNQRNTNLALQKMFFLDSFVSITYSIITLAFPSQIIKFTFNKSGSLDSFHKLYCRYFGAYMLYSAIMSANAISLRFKQQKNYAVQRAITQTIIFSLHVFGHWGLGIYSPNHITPFMISGFYITFILSIYFRVKNREEEPSDLDNESDEDNEDEYNSDTQTNYKGKLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6H3</accession>
    <name>A0A0N5B6H3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6H3"/>
    <dbReference type="STRING" id="174720.A0A0N5B6H3"/>
    <dbReference type="WBParaSite" id="SPAL_0000166200.1">
        <property type="protein sequence ID" value="SPAL_0000166200.1"/>
        <property type="gene ID" value="SPAL_0000166200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000166200.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="44084" checksum="168927B428B3767C" modified="2015-12-09" version="1">MRSYVSGRNFNNPTSKYENQRITNSITRNPHISSWRDVGIGSDNKFYKSAEKNDGRKKRKKYIRNGGSFIFLCHLIIVVAMCILTLNAVNIFQQQASVEIVNLVNLPYSIKLIMNECGNLAVQIITSCLLIEITSLYFSKARANFLDIMSLILFMILGYLKWKNNSAVERIFYELALTSMTSVVTFANLVLPKLPKHKTKPNSIMSAFHVDSPSSQCESMFEYSDTVEDEKMDVDECNTETENAFVNRLKFRDTSRDDTPIREIRPLLNNFKFDNSDEGSRIKQKENVFSRSNLISNNKGYSKPLFSKPLYTRESYLESKENFYKSSTIPPLLKEKNCSNIVNEPGYCKIRKSYVFIGVVLLIVNTFYNLFSFYQQFRQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B755</accession>
    <name>A0A0N5B755_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI ethanolamine phosphate transferase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B755"/>
    <dbReference type="STRING" id="174720.A0A0N5B755"/>
    <dbReference type="WBParaSite" id="SPAL_0000188300.1">
        <property type="protein sequence ID" value="SPAL_0000188300.1"/>
        <property type="gene ID" value="SPAL_0000188300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000188300.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23138" checksum="4D710E0F540CD969" modified="2015-12-09" version="1">MMFDTKITIIYVTCLYCNISSFNINLISYSSLFYKVLLTPQKEKVEDDGDIKESTPESFEIDINSIDVDEGLTTLSRINSRSTSITSRISIKSIDEKTNDSKLIEKEFTDTGSVKKIVYLKYFKATRYHLAFLFAFGYMVYNALQLGRSLWLSKWSNDYDIIANNGTINPSGIPLGVRLGVYSSFGLLESLGFFVLCLHSFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7D5</accession>
    <name>A0A0N5B7D5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-like GTP-binding protein Rho1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7D5"/>
    <dbReference type="STRING" id="174720.A0A0N5B7D5"/>
    <dbReference type="WBParaSite" id="SPAL_0000196100.1">
        <property type="protein sequence ID" value="SPAL_0000196100.1"/>
        <property type="gene ID" value="SPAL_0000196100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000196100.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22576" checksum="2E17E4BFF18102AE" modified="2015-12-09" version="1">MSAIRKKLVIVGDGACGKTCLLIVFSEDRFPEMYIPTVFENYVADINVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCYSIDSPDSLSNIPEKWTPEVKHFCSNVPIILVGNKMDIRDDHIALEELKKLNQEPVKYEQGKAMAEQIGAFAYIECSANNYNSLKLIFFRMSVRYLRWQLGQHLLQKRSMVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8C5</accession>
    <name>A0A0N5B8C5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UbiA prenyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8C5"/>
    <dbReference type="STRING" id="174720.A0A0N5B8C5"/>
    <dbReference type="WBParaSite" id="SPAL_0000229800.1">
        <property type="protein sequence ID" value="SPAL_0000229800.1"/>
        <property type="gene ID" value="SPAL_0000229800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000229800.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38834" checksum="36D832A84C403B23" modified="2015-12-09" version="1">MSVGGVCSLAAGIIVSFIPITRLIHSMANDNLLKIPLANKIFGKSGSPRVAVIISCCMQLPLFFINQTYMETIFYLIVFFGTLKNIISSVLYYYISFNDEKYINGTETSQSHELTYRKFVEGSDSENNYRSDEETSTDEELDYVFKGQYKGKNFRYGTINKSHNCLFQECQTVGKYPLGHIYEIPLQTEVHLTNTKNDGKIFKCITKKHLTSETANWWLVSYLFCTVLSTAIIKYNDHETLKKQPIFISILLFTLLSFSILGILYVLISIFFSDVNDNLNDKTNNKANVKRKEILQRLLSIYILQLGIAYFDLYNYATLIIWLTIGIFYYLLIIDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S0</accession>
    <name>A0A0N5B8S0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S0"/>
    <dbReference type="WBParaSite" id="SPAL_0000244300.1">
        <property type="protein sequence ID" value="SPAL_0000244300.1"/>
        <property type="gene ID" value="SPAL_0000244300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893957" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244300.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14198" checksum="E23D0DBE4FB8A43E" modified="2015-12-09" version="1">MKILYLFLAVSLTFSFTNGKEIECQRFCKYLSGDLEFVQSYCLSEVDYEDNVCLSTEELGCSIAKMNFDGTLILAGGCPTPEFITQTGIKKNDCGYFETFLNEDEIQLSSKICRCHEGLCNNETAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9E0</accession>
    <name>A0A0N5B9E0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9E0"/>
    <dbReference type="STRING" id="174720.A0A0N5B9E0"/>
    <dbReference type="WBParaSite" id="SPAL_0000265600.1">
        <property type="protein sequence ID" value="SPAL_0000265600.1"/>
        <property type="gene ID" value="SPAL_0000265600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000265600.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18177" checksum="873572A927209364" modified="2015-12-09" version="1">MTSLNQLVKVSRPLGRMFQQRSMYDNPYLKRFKQKSEVSPNHFKQSTGLTGLFVNEYPHRSLKIIYERILRTLEKMPATSVYRMSTENIVKNRLALVEEEQDIQKLEAKIGMGQIEEVIEQGEYELQAARAILESKAWEPLPEKPAPEQWRWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9P6</accession>
    <name>A0A0N5B9P6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9P6"/>
    <dbReference type="STRING" id="174720.A0A0N5B9P6"/>
    <dbReference type="WBParaSite" id="SPAL_0000276200.1">
        <property type="protein sequence ID" value="SPAL_0000276200.1"/>
        <property type="gene ID" value="SPAL_0000276200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000276200.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33587" checksum="08D8904267192A3E" modified="2015-12-09" version="1">MKESNISTDDILYNMNQTYVKNRHICTIENFKLHIGKPGDKFISEPFSFGTTEKSDWYFWLYPNGDSSKTEGYLSIVFKSLDYSGSAMKSKFKFYIINNKGEEKYVSESCTLGSYQCVNYWTVPNFARVDTLLDPSSGLLRNGNLVLLFEIFLIGSNNNITKSHSTTQFKLDETLPKLDNYLDQILLRQLSTDCIFVVGKYNFYVHKHKLINRSPVFGAMLKDQLKESKKSVIEIVDFKADVVKEMLDYIYTDEAPNLKEMAVEIFMIAYRYGLNGLISMAIKHIINKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA22</accession>
    <name>A0A0N5BA22_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein 39</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA22"/>
    <dbReference type="STRING" id="174720.A0A0N5BA22"/>
    <dbReference type="WBParaSite" id="SPAL_0000289100.1">
        <property type="protein sequence ID" value="SPAL_0000289100.1"/>
        <property type="gene ID" value="SPAL_0000289100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="172"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000289100.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56977" checksum="699DB9577E3AAB8A" modified="2015-12-09" version="1">MTTELAHNILEEAFEDKPKHKEKSVESDRKSKDSHRKRGRSRSRTHSRSGSRSRSESVDDDKDRKHKRDREKSKRYKSRSRSRDRKHRSSRNRSRSRDRRRRSRTRSISRDYDRGYRRRDKDDYSKDRRRDQARRNKRSPPVRERRDVMPYKPRPPPPDVNPNLTPEEREERTIFILQLSKSTRPRDLEEFFSAVGPVRDVRIIQDAKTMRSKGIAYVEFWKRETVALALGLNQERLHGCPLVIQRSLAEKNRVNSGTVASSIGFGTAETGKGPVTLHVSNLHSALKSSQLQQVFGSYGKIQSVELFPSADSNIGQVGLVTFAEAEHARKALADLHNFLIAERHIKVVVFDPKTMEKPVAHVGATNNTTDVNRTKQISVNQLTPPVKQEPYQCFVLVNMFDASKEEEDGWDNEIRLDVIEAVYEHGGAVHVHVEKNSQKGEVYVKAVNPEVAVKAVTALHGRLFEGRTVQASYTLLDAYHELFPESIYATEILKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB15</accession>
    <name>A0A0N5BB15_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferroportin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB15"/>
    <dbReference type="WBParaSite" id="SPAL_0000322900.1">
        <property type="protein sequence ID" value="SPAL_0000322900.1"/>
        <property type="gene ID" value="SPAL_0000322900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000322900.1"/>
        </source>
    </evidence>
    <sequence length="860" mass="97255" checksum="24F33F7C38FF77CF" modified="2015-12-09" version="1">MFAVIFIMEKIGGLKLIALSQLMNGLATMLLSGVLGKWIDKQNRMKSVSTVLFINNIFISICAGIYMIVLRMESDNSLFDILIYIGLLLNGISEVASQGERMLFSKDWILVLINNDQSKLCEKNAKMTTLDQMTCVIAPIFVGILLKNFYYDKVCLIFMLWNFVSWAIEYILIKKLYKGNTNLHIKSCGDSIKSKNEISLSNVINIYFSQPTCYQSLALSLLYLTVLGFDGLSLSYAKAHNMSEDILGIFRGISALVGIIGAFIYMKLERKIGAPVAGLYGFFIQQFFKYCCLVSLILPGTLFDPIGYFSEWDFKDWSSKLLSTSSDNFQLSNISSSFNPSVWVYLITIVFSRIGLWLIELSITHQMQLSVKDYDRGAVFGFHNSLFIFEKKFLMKGKNLTIYHFYFAYTLSCLSDRLWEFAVIFILEKIGGLKLIAISQLLNGLCTIALSGILGKWIDKQNRMKSISFVLSINNIFISLCVAIYMIILRMNTDNTIFDILMFIGLLLNGISEVASDGERMLLSKDWILVLINNDQSKLCEKNATMTTLDQSTCIIAPIFIGILLKNFDYDIICLIFMIWNLVSWIAEYILIKKLYNNNLSLHEKSCDHSIKKEEKISLTNIIKIYFSQSTCYQALALSLLYMTVLAFDGLSLAYAKAHDVSEDILGIFRGISSLTGIIGAFIYMKLERSIGASTASLCGLFIQQSFNYCCLISLIIPGTLFDPIGYFNEWNFKDWSSELLITSSHSFKLSSSPNSISIFNNPSIWVYLITIIFSRIGLWLVDLAITHQIQQSVKDHDRGAVFGFQNSLCNFFSTIKDIFVILLPDVRTFGILMIISVAFGTISLLLGLYSSIKNKIMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB17</accession>
    <name>A0A0N5BB17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BB17"/>
    <dbReference type="WBParaSite" id="SPAL_0000323100.1">
        <property type="protein sequence ID" value="SPAL_0000323100.1"/>
        <property type="gene ID" value="SPAL_0000323100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894108" evidence="2">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="121"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000323100.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31334" checksum="9D74AF4DC80C3734" modified="2015-12-09" version="1">MNLFLTSVLYIVVIIHIAFVSVKANPSDSENENELLVSRKDSDSRSSGQRNSRRRSSQSSNKELKLNSNRKVFRRRPSLSNHHCSLSIKLYLKGTKIRSSIHDTVWHDFSYQNYWVNSYLIYKLKIIQHINLLRLVYGVCPLKESESLNELAQDYSQYKATRRFFNKNLIKDCGIIKLLLSYSELPGIVSTLYSERSHYSFLLNSGKGIADGFTQLVWKSTTSIGIGIARSYDYFYITLLFYPKGNIWGQYGKNVLKKQISWKRTMLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBJ5</accession>
    <name>A0A0N5BBJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000340200.1">
        <property type="protein sequence ID" value="SPAL_0000340200.1"/>
        <property type="gene ID" value="SPAL_0000340200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000340200.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8581" checksum="A15D0FEECE38B70C" modified="2015-12-09" version="1">MIMIPSAERKLLQGYKWTNCDAPRISIFFGLHDEYLKSVTLQYVSLVPVNEDYTPNIIGEMIIDMDINDNLIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCF6</accession>
    <name>A0A0N5BCF6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCF6"/>
    <dbReference type="WBParaSite" id="SPAL_0000370500.1">
        <property type="protein sequence ID" value="SPAL_0000370500.1"/>
        <property type="gene ID" value="SPAL_0000370500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894346" evidence="1">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000370500.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18482" checksum="DB11B538680D4559" modified="2015-12-09" version="1">MKLYTFLFIKIILIHVIFLCNGVREICTGPGQSSPCFIYFKPEETFFQRVLSLVDTVLAMQVRKTYLGYKKDPNVLMGANSYILKRFSQPMIRQICMHFPKNLVYKNPTIINLEYHKNTNQVLNNQGNMMQQHKQNWAQRAGIRSMLMLKRGFRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDQ9</accession>
    <name>A0A0N5BDQ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BDQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000414200.1">
        <property type="protein sequence ID" value="SPAL_0000414200.1"/>
        <property type="gene ID" value="SPAL_0000414200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
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        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="564"/>
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    </feature>
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        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000414200.1"/>
        </source>
    </evidence>
    <sequence length="875" mass="95765" checksum="6E2511A409B872E0" modified="2015-12-09" version="1">MFSGHPILAEIRQGTRLRPTKTVDKSKPVIVADGETLNTILDESKVPTKTLNCENSLSSNNNNNGPPPPPPPMTSSGIPPPPPPIGDKIQPKNISNKPVNTKFQGLGGKVTVDQDEFIKSIQHGFKLKPTVTNDKSGLIFDDEQLEIINAAKNASSDGSEDGKRKVLIEFKKPQEGSSPLPPPPPPPPMMMNVPMPPPPPGSMATNNIPKKPTKPITNPKLLKLGGGTAANVDKDEFLNSIKSGFKLKKVEVVEKNSLYFDEEELQHLSKVRDETKASSSNLSSYTASSENLFNSSHATSTSSLLNGDNYSSTSSLMDGSGSFEPVKKKEFKWKVRDVKEETPPAHIDAGWNLEEKKWNPEKMTDEIPKGSAKARIAMLAKLTSSNESLASNGSSSGCKFKLSTLKKDLFERKEETTPPREVKKEIRPVKKLDYKMLENTNNNNNNSVQKADDIKVAKKLVERTKLEDSFDFDGITLNEDEADEIMKEAMRLEEKPIPKPLDKSLYEAKFGGSCNSLIDSTYNDRRDRDITPKPLDKSFLASPFINNATAELPSSAQPSPRASPGRFDRGELEAKFGGGQPLHFPTEKEDIKPKKEISIKVEPQKEEEVEKKKVIKKIVKKKVTPPSSKLNILPTNNGTTNPKVAVNGKIKSSEELNTPLSIDTKNNSLKIGNVSAMRNQFQKSVTPSPQSSNTLGTSSSSIKSRSLSPLAVETSSPTSPSLSQYKTAPTSAASCRTINTNSESSTPVSLSPVSSTGSIGGRKNSSDDGKESSVKAFGRYNPKVVNSNSSRFEELRKSFNVKKDDMEPPKFRVSSASPLSGEHIWKQAIKEKNTNNNLSNNNNNNNSVSTNNGKDGVTKNRAVPIKLTNEYKRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDY3</accession>
    <name>A0A0N5BDY3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDY3"/>
    <dbReference type="STRING" id="174720.A0A0N5BDY3"/>
    <dbReference type="WBParaSite" id="SPAL_0000421100.1">
        <property type="protein sequence ID" value="SPAL_0000421100.1"/>
        <property type="gene ID" value="SPAL_0000421100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000421100.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38437" checksum="607461C165DBBD5D" modified="2015-12-09" version="1">MMRIMEAIQRKKLIQMLNVEYAQDLENEAAHSFAESRKLSNMGSINKSSCSFKGSNIDGESLLSPYHSPIHPTFDPIKDKNKIELIQFTDSLERKLSDLQKKALKITWKRLSEAPRTSSKGMLFIMQRVFDLLIERNSEISTVFYRCAFLSCLEDRKKIVTSLNKNTDTKKCPYKLKTIATIRDHANILLDFVNSVICLMFDIPYQESTYIGLSSLGCTHSQLMPLGFQQQWFHHLGECFAEVMFSQECVRAFPHAASAWSLFAVTFTDKLYVESRWRKNKPKTKLPTSYSLSVMPSPSDDVIVDKNKKYSVPAKARVNYRHQFPEEKNFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE05</accession>
    <name>A0A0N5BE05_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE05"/>
    <dbReference type="STRING" id="174720.A0A0N5BE05"/>
    <dbReference type="WBParaSite" id="SPAL_0000423200.1">
        <property type="protein sequence ID" value="SPAL_0000423200.1"/>
        <property type="gene ID" value="SPAL_0000423200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34059">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34059:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000423200.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="76849" checksum="115324DD6870A557" modified="2015-12-09" version="1">MSALSSWYERYKAEEARKQRIQEGLEEEEYEEEEEYEEEEEYEDEEEGEEEEEEEEEEEIEEVKNIEDKKEEKIEDKKDPKKEDKTEDKKYTKKEDKPEDKKDTKKEDKTEDKKDTKKEDKTEDKKEVKIEDKKDEKEKSTKNDNLPDEKAKKESDKLKSDDPKNLAKNEKEKSEQKIETPKSSKKVEEEKTKTPSKAEPSKGSVENKNDKPESKTETSTDSRTKTSSVSVKDRINKFSDSTKAKPSDESVKNKDNDSKDVTKGKLPSESIKNKDTKSDDLTKKPKDSKTNEKPKKPSTKEKEEVKEEELNVEETSDEKNEDEEGEEDEENEENEDEEEEKDNKDENNNDKNEKSKEVRRTEIVKDTNIIQNMDFYKEHINSVQKELNDIPMPPKEKTLCEILKEEKISPTKRYARRVRENQIKLPSDVPFEQRPAKESQMGMGGFGCRRDASLKIKHGEKELVQGLVHSDTVIPLLSSATPDMASQRGMKSFGFTRPVVDQVKDSHKYNSDNKLYMSNSIIPILAKGTIKDKRLASPFGTNRSQITNVTCSTGNATTFDKKSNGFISKIFAPTSHKAGSCIIDKPRQIISKIQGTNTPIVLPSRESESILPMLFDATVQEKRSGSEFGSFRPLYVESEGGYTMTLDEEIRCKLILPYQTRGLTGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF34</accession>
    <name>A0A0N5BF34_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF34"/>
    <dbReference type="WBParaSite" id="SPAL_0000460300.1">
        <property type="protein sequence ID" value="SPAL_0000460300.1"/>
        <property type="gene ID" value="SPAL_0000460300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894265" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000460300.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11883" checksum="4BE610385F18CF08" modified="2015-12-09" version="1">MAYSSILIKVTFLIIGFILLISAESIKNVPESEQFNTNEGTELFNPHFYQFKKFQYPIDDEIFSYYQANEQIPIRDRKWASQLRYGKRSSWASQLRYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGU7</accession>
    <name>A0A0N5BGU7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000519700.1">
        <property type="protein sequence ID" value="SPAL_0000519700.1"/>
        <property type="gene ID" value="SPAL_0000519700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894338" evidence="2">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000519700.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32098" checksum="ECD0463EE0DF4873" modified="2015-12-09" version="1">MTTFVLFLVNFLVYTTYCQVEVENPNLKFLNLTLYDEYSNRTTTGISSSGTSRQYDSSSSPSSFSSNSSPLTDEQQNELNYQRIQQSYALNPDPTAGMTFTNNIYGYDYRSNPSDSYTINGNPQQYTPPPIIQRSKRQAIPGSDIYAGTAYANQRLLFDDNSDVLQDYRLYDPQNTGTSGTSTNNGVLRDSTSNNGTLMYYPYRTNITQENVSQINATNQILLRDQENANCANSDPEWCSEYVRITYQGLTKYDKLSRSSACTRLKNSLKDSISSCCVAVRGIGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH35</accession>
    <name>A0A0N5BH35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH35"/>
    <dbReference type="WBParaSite" id="SPAL_0000528000.2">
        <property type="protein sequence ID" value="SPAL_0000528000.2"/>
        <property type="gene ID" value="SPAL_0000528000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000528000.2"/>
        </source>
    </evidence>
    <sequence length="274" mass="31715" checksum="3D25FC353A096582" modified="2015-12-09" version="1">MNNNCTKYLSTLREAKSTPYLHPFDSNSKSSKNYKGCRCYSVTHLSLKDANHETIEKPKKIFFNAGCSSSSTDINRLMQFYNDSADLDVVAHWIKVYEEHKLKTKGDANDNNNMMDDNFKEVFEGENYEKKNMRYGSFDSFDSDYDGFSMSLQKYKSRCNCHKKNLSEEGNFLKKIAHNGNDFEEENVYCSKCSFNDKRRFSTGYSANNRSLDSFTQPTTSKIPFKLSDDSSNLEKCASADFRCNKEKIIERKLERCREMLNISSIADDTNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH88</accession>
    <name>A0A0N5BH88_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH88"/>
    <dbReference type="WBParaSite" id="SPAL_0000533200.1">
        <property type="protein sequence ID" value="SPAL_0000533200.1"/>
        <property type="gene ID" value="SPAL_0000533200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000533200.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18420" checksum="0D32DC049C86737A" modified="2015-12-09" version="1">MIKEINLDDANLLDDNSNDVAKPTDIVDTNPVEPTKGSKDKHPNLSDSPLIPSDGKGSKKRGATCPIEEFVQQTYCCLMSSKSFETYPRLVGADKMDKWRNQITPSTHSQDGIPKYINYGVVSKTNSLLKIYTEDPPNYFNSIVLQIPFGSSKPRNSSLGERFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHE3</accession>
    <name>A0A0N5BHE3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-N-methyl-L-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHE3"/>
    <dbReference type="STRING" id="174720.A0A0N5BHE3"/>
    <dbReference type="WBParaSite" id="SPAL_0000538500.1">
        <property type="protein sequence ID" value="SPAL_0000538500.1"/>
        <property type="gene ID" value="SPAL_0000538500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="128"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000538500.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="82522" checksum="3AD0DDC110BADA19" modified="2015-12-09" version="1">MNNEKWELKVSKLCSSTTIPEVPPIGHQMNLEDFMSFDDVANSIVIDVLLGIRSHKMRPKKIFLTNGEVVICYNLLRKYLENFNVFRTLEGIFLLPSMKNFCLKMDSKRLTELRNHIHRYLMLFQPISGISIQKCFKYSKEKFLGAKLVATRKFKANEQINMLYGVVKPLTEEQLKKDIKSGVNDFSIMISDRNEKQILWLGPGSFLNHDCNSNVKFDCRGIHTVVLIATKNIEIGEELYLNYGENYFGENNKECQCETCEKIKNDKDNLIKWVPEMCREIHENIVECLELISLRNEILKKVYDFQIPRNNLIISLNYMAEFLKYGFMEDGITKISINQHYIKHKLEYLSNIIYLISQEYDLEFMQIFTYFYKTFGICTSQGKVGTPTTRSLILEKNEAIFKYAFYEAIFGSDVAGNLIQFQSKLFEQYHCEKVSMGQIICVLQNFINILRFKDFKKAFQDKIDIQNRRIKEIEDHGFTLEFLLNISDIKVDIFGPEPIEEQKKYIDRCIKGCEEIVNEKLRSYLAQDFVLSFFNDNNELNGIFNDLKTILDVYKQNTKEQTFNNKIKGVEKIRNPLNIGIEDFNNKDNGAILKSLFNDQLEEITRKYRRSDVIKTIDINNYMLLDENKPKIVRSSKRLTKESCKNETYNIEPFLMKFYCNSTLEKALKMKKRSYQMINQDFEGVFIYGNRLKDGREILKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI24</accession>
    <name>A0A0N5BI24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI24"/>
    <dbReference type="STRING" id="174720.A0A0N5BI24"/>
    <dbReference type="WBParaSite" id="SPAL_0000560900.1">
        <property type="protein sequence ID" value="SPAL_0000560900.1"/>
        <property type="gene ID" value="SPAL_0000560900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000560900.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24079" checksum="3CF63C4A1C74B7B7" modified="2015-12-09" version="1">MDKELITPWGRVEDLLGIIQPGDNLECKVGTKIGNGVFQHWGTYIGAKNDIHEVVHYSKGGTDNEDQKSSITSFYFWFKNIGNDVSIRIDNLYDFSGESLVRINNSMDKNHKPFPKEVIVERAKRRVGETEYDVLSNNCEHFVKWARYGLPISEQAIVAEAMVIVFAVGIFTKIIIMIVFIHLPIILAIIMTLSILIPCFIVSYLLSVCLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI52</accession>
    <name>A0A0N5BI52_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI52"/>
    <dbReference type="STRING" id="174720.A0A0N5BI52"/>
    <dbReference type="WBParaSite" id="SPAL_0000563600.1">
        <property type="protein sequence ID" value="SPAL_0000563600.1"/>
        <property type="gene ID" value="SPAL_0000563600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000563600.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="71393" checksum="DF9C7161D0656CF2" modified="2015-12-09" version="1">MEHSGPMSASTYGKRNNAAEVLRRKQAAEKEQEIKLQQKLREKEEKSRRAAEAKDQELREKTRKIHEKELLRQKMVLDRRAAQLEQDSKKKMEILTKAHAATSRLVCTKTGNGSPQQKKVYAFGSSTPRDLVYLEKLSREQKVYNNKLVAPASSSGKSSQGQSTTPSPNKMPIRSNVAFGSSMTSSLYVSPSQKVLPVQRSPLNPVPLRKGPSSTNNTPNRNTNNVPPPPRRSVPRVSNSMTQSMYTPRTSVGFRSNTTLKGNGTLNGQLKPNLNSTQARNVNKVPLPHPPKKNQQMNGDVKKVKNQMVKPKDHDTVTTTQEDKDQIHHNVSEEFHSVERNISLESLHSHHEDEVTEVINDVVSAQVNYSIEITPEITTNNNEEFTNDVEVKSVSPAPVPETLKLPEKLPILEDENSPEPVSTLEENKFDSGVDSETPNDADQIVRNSIGVNSLTSALAQMTIRTPASKKTPEEVSTLPHSSSSSSSSNEDLASIYQMKSVLKAQIQKQKDERENRSARIKALLSKVRGSETSDPLTTGTTTSLHTSISPILNIDKKVDDDTTIIGPTTSDLGVSVSTAKTLEKLRRRKEKNSEMVSSTTSTPVVEKSIAEELSSLGVNLPGQPTYDYPPEDPKVNGGTFTSQTAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJC0</accession>
    <name>A0A0N5BJC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJC0"/>
    <dbReference type="STRING" id="174720.A0A0N5BJC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000604600.1">
        <property type="protein sequence ID" value="SPAL_0000604600.1"/>
        <property type="gene ID" value="SPAL_0000604600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="484"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="599"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="7">
        <location>
            <begin position="768"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="933"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000604600.1"/>
        </source>
    </evidence>
    <sequence length="1257" mass="144117" checksum="FF5696F623B91AD5" modified="2015-12-09" version="1">MSESESYHSSNINSPMTPEEIISEKSAKIKKWVMNRLQELEDQNERLKAQNLKCTNQLKALSSLAEKQKYWKSKNLNQNFFSQSCIGMLPTSLSKTNFDLTSITNQQTTSGIINGDCYRTSDDSGLTSDSSGAVMCTIMTRSTAPVINCTNTTKSPRTKKRDVRSNHRNERKDDVMSSATDSSPYDEEAKPIPTPRRSNKTNDKYKCNEKVIDIELASNTASIERDSLESPSGDDDDSYNDYGIEVEEDEIFEEIDICKEEGRQKFPENCFTNVTPKIVKKDFVKSLSPEYVNMKDIILAKNDNFEEEKSYDCVKRDKCFKDSLLSKDLFNKTVESNDMPLYSNIDKNKINFASSPLNPIKYPFEDRLQQMAEKCLSIVENDNTPTSSSKHSSGIPETTVTSFNRSESNLSYGDKLIYNSNGKVNSTTMSYCSSTHIPSTSNGNINNNNEYQRPNSYKNDFIKNSPCISGSSSLRASLVPGRECYEKQGNLTQMTDNRLKSIKRRYFVLKNGYLTIYKNQKSMTREEGLCMHIPMKDIKSIVRITSKNNIKGIQITTNESTLRYHSDSDLATEEWFLVLTQSLRNATINDLSTREKAIPSIISGWMYKVKNGHQRKHYVSLVDQKLLFFKKYDDKIPTSHIYLHGAFVTEKSRSKLSSDEYSGTSEDDQVTGDEKINNPHLINEIRKKTDINKKGEYSICIEVPNQDPVYLILNNNEDKDKWLYYLKVASRDASLQGSAFEILLQKILIKGSEQINYMLFDDLLLKPNMKENLMEPLTSIENKTLAKKAVEMDRAVHLFVTVQMNPNAFQYHVDLAQNIITTAMEDELLRNELYSQLIRMTNGSLTNCNQGWRLLALTLPIFLPKQYALLWFLKQHIRRWYNIKNDDTPIVRYCESLLETCIHSGSRQEPPSKLEAKIILTKDFSNSQSNMPFSIPILLPSGDYQMIEFDGTTEIGHSLSSLCLRLNLRPALLSGYALYAQDPLGSPNDLVLLKGKQKLCDCISVWEKQITVNGKGKIVEDGSSIKIQLRMRHYWRHLHNDETIMEQLFLCHRMGEEIVKGQIPISNELGEELAALYGQMIFGDYMPSLNIHLDEILEKYYPKKLFDVVCVRSLKVNVLQKWVEFKELSINDCVRMILFALKKWKLFGSFMKGAQMKLPCMQGIFIAINESGVHLLSEKQLEIIRTIPLHSIVSFGEYNNDFMLTMIRQVSPSAHPEETPRERITFTMDRKSIEQMTIHLAEFIRCQKLIWKLSINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJL0</accession>
    <name>A0A0N5BJL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJL0"/>
    <dbReference type="WBParaSite" id="SPAL_0000613500.1">
        <property type="protein sequence ID" value="SPAL_0000613500.1"/>
        <property type="gene ID" value="SPAL_0000613500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000613500.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="48437" checksum="B234115DAC6FCF8C" modified="2015-12-09" version="1">MERAEVLRQFTDIEGSNKVRCIHCKETLSKIYCNLRRHLGSKHKSTGIGSKIKSDSSKKIDNREIEMQKQFDLLMVRLNSVCSVSSYLIETPIFKELVSFLNNKVKLQSRRTIKRRMTEIYNEMFTKYIQELVEADCYFHVSLDYWKHNTENVLLILISWEKRSFILSFSLFNEENDFNDIINDIEESLNFNDSEFESMEVDDVLSICNVDNNVDTINLSTQFESPIRIWCLSHKLNLLFKDLVNMECFKLVQHIYTYCVSIRRRDKVHSYLKQHTGKGIILVPKTRWIYAYRMVHRFNQLSSQLKDFEDFYFDDEDIKAAKEIESLLNVLYITSENMQKNSFGMKYVVFILGKLYFLVKKLGIRDQFKNAYFKAAKKRFSDVLDISKNPIFCIFKILPNIVRKKNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKC3</accession>
    <name>A0A0N5BKC3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKC3"/>
    <dbReference type="WBParaSite" id="SPAL_0000638200.1">
        <property type="protein sequence ID" value="SPAL_0000638200.1"/>
        <property type="gene ID" value="SPAL_0000638200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000638200.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9035" checksum="6CB0C969B5978E1B" modified="2015-12-09" version="1">MTIERTNSQQVKMSFNDDRYLKLYKKVKDELEGVLGKMGEVFDERKRQENREILAKIDKTIRKSEDDGDTVYYSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKG6</accession>
    <name>A0A0N5BKG6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKG6"/>
    <dbReference type="STRING" id="174720.A0A0N5BKG6"/>
    <dbReference type="WBParaSite" id="SPAL_0000642300.1">
        <property type="protein sequence ID" value="SPAL_0000642300.1"/>
        <property type="gene ID" value="SPAL_0000642300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000642300.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15245" checksum="0D89B0BFAB97CCE7" modified="2015-12-09" version="1">MPNFFMNLFSSSLSSDRKGESLRIDNLFDTCGNDECRINNLMDKYDKPLSAGKIYNRVTSMISNGAYCVINNNCEHYTKWCRYDIYMSQQMNVGKGIITGVKTFLESKSLLQASAAGVLEYINLQLNGSSKKHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKK1</accession>
    <name>A0A0N5BKK1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKK1"/>
    <dbReference type="STRING" id="174720.A0A0N5BKK1"/>
    <dbReference type="WBParaSite" id="SPAL_0000645700.1">
        <property type="protein sequence ID" value="SPAL_0000645700.1"/>
        <property type="gene ID" value="SPAL_0000645700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF177">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000645700.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27833" checksum="DB95273CFBFF7405" modified="2015-12-09" version="1">MALQLQNVESDPLGKLMEQYNRLANETKSVVSKNENNSINSNNIGKYDLKGYQNLSDEGTPNINSYSNGTQNAMYGGYTWPNPMGWWSNPTTGTNDNTWGTALTTYGTSNNDINHLTNSPSYNPYFSSNFPSLLSAASISTTSPSILPYSVNSKLSPNQNTLKYQDTNTQVLKNSPTNGTTHVGGGKISSTRAVCECPNCLEAQRIGIINVPEKKRNIHNCHIPGCGKVYSKSSHLKAHLRWHSGERVAVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL64</accession>
    <name>A0A0N5BL64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1794 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL64"/>
    <dbReference type="WBParaSite" id="SPAL_0000666600.1">
        <property type="protein sequence ID" value="SPAL_0000666600.1"/>
        <property type="gene ID" value="SPAL_0000666600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF16">
        <property type="entry name" value="THAP4-LIKE HEME-BINDING BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894553" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000666600.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21839" checksum="397A5F1293EEC6BC" modified="2015-12-09" version="1">MAYLFVIFVFCKFILHISCLVPSDNEKLSWMIGRWRSEFSGKVVWPTIPTMTFGEEIEIGHGYDAFIDDNKVHFLNFTAKAWSHTNKDQFHSEWGHLTANRQGQVTLMTSGGNGFAKYEVGSFVGNDKIILNLKDIGRISFSRDLPVEDLRRTFVKVGDNYMEQILEMRTATHPETGLLRHSKVVYSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLW4</accession>
    <name>A0A0N5BLW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLW4"/>
    <dbReference type="STRING" id="174720.A0A0N5BLW4"/>
    <dbReference type="WBParaSite" id="SPAL_0000691000.1">
        <property type="protein sequence ID" value="SPAL_0000691000.1"/>
        <property type="gene ID" value="SPAL_0000691000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="282"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000691000.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67509" checksum="6F1549EC2ACD19A9" modified="2015-12-09" version="1">MQKNGKRTIHDLSCQFGARGFSEEMREAVGTTQEGLTEFLNHYPSLFIVENDTVTLKGFGEMDGKNQIMKIPGTGSRNRDYEKEAVDFFVTKLQKFGPELQIKSLLGHRSQAAPEVRLVSGRHLKEFCEFLQSQTEHFVVEGDRVRLKNMPEPSHGAVELDEEGNPLAGVKAKQAALDFLRNVLEQNDEQPIPLDLFYQRFCERFTHTVRQEVATNPKELLQFLKLNRNVFFIRSNKVSLVKNKPEENGSESGRSTEGSESTFSSDNNNTLYPLNKSSLSKITSVKSLAQAQEAIKDILNDLDNQEEKYVAIDFKLVTYGGINSEEFLSLIVIASQKRIQVFDMANSKVLLLESGLKEILESEKVLKVIHDVKRVSSLLLTCYDIQMQKVFDTQIAHSVIQHDKFGKSFSDLRAISFLNLQRVYYPQSIMMSDITPRKLSQTPKWDQRPINDEMMLSVVEECHCLITAMYKILNQQVPPQCQELLEEKCSEALLPQPIKTPNIINGNGLSNAIANQLNGFSNNSVKTSKKSTQSSVHNQKDINNECQNMINNNNVNSNNRSTNNLTPSIPQTKPVMCDMGTQTFSTGEIVVLNVYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMF4</accession>
    <name>A0A0N5BMF4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMF4"/>
    <dbReference type="STRING" id="174720.A0A0N5BMF4"/>
    <dbReference type="WBParaSite" id="SPAL_0000709400.1">
        <property type="protein sequence ID" value="SPAL_0000709400.1"/>
        <property type="gene ID" value="SPAL_0000709400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000709400.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71018" checksum="6256350CC2C97EB1" modified="2015-12-09" version="1">MVVEATDILKEHDGIFYCLECPFWATNFSVTEAHAKGHLEKFTHCCDKCQWSADDEIEIKAHEQWHSSEVMINDENEEIMNGNNVWNCDECPYKTHDVYEMRSHTRLHQGQRSQRCSQCTFSCDGPSALSQHLQIHGKVTKRGKPKRQTIKREPITDKIVSKEIMSKTENGLSVRALKLVIKSATLKETYEMHKCETCPYYAASEDSIFKHVASHILPKGGRTMQECLDCEFYCESSEVLKEHVRVHNNAFIIPYFIQTLFSCKMCDFTSSEEAVLKNHEQKCSKEGMQGGSSICTNGKKPYRGRKRKAPEDEDTPPTDNSTREVSTEDADSMTLDDWLKEYHKKFGLPRTVIETKTKTVVKERPRHNVLNLYSSRVNSANDGNYNCRSCPFTTRFQAVMRAHETHHRYTQQHNCSICSYSVNDVRNLMNHLKWHEVDDEINNVEKKAGMKKNGPYKALTSRVGSGSHQYECPFNPCTFKSPFGHSLNAHISDHAKKHKLRIFTALKRKNGDILKNEKTFKPPKESKNPLMCGECQFSTHFSDELFDHQEAHKDIYLEYQCTICSFGSDSLVYLNTHLTDHHTDEVKNSADLTNFNERQHRFKLYLDSLTKSSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPT2</accession>
    <name>A0A0N5BPT2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPT2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPT2"/>
    <dbReference type="WBParaSite" id="SPAL_0000790700.1">
        <property type="protein sequence ID" value="SPAL_0000790700.1"/>
        <property type="gene ID" value="SPAL_0000790700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894838" description="peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000790700.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35744" checksum="46C6AAAAA8462067" modified="2015-12-09" version="1">MANFLLIILFLLIKNSIERGPEDSIPVIEIRGEGPPMSSAQIRDLEERANGRPLDIKTEKIFTPNVCEEKVDEHDWVAFDYKGFTEDGKLFDTTYNGKGPVRIQMSTGMSILGLEKGLMNMCVGEKKRIKIPWRLARKNKSKVWKSFPSEEHWINVEVEVVSIDKWSIEKQFKELDYDNNSIIDVDDLVKVSQKLDDFGKRWSNNDIDNVIAGKYFIKYFDINQNSKIEENEYSQIMKRDINAMEKSNPIRDKKGEFVGKKREPGFEWILDHNNDGYVQPQENYEADKIFEKGIPIRDPTKIIKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPU2</accession>
    <name>A0A0N5BPU2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPU2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPU2"/>
    <dbReference type="WBParaSite" id="SPAL_0000791600.1">
        <property type="protein sequence ID" value="SPAL_0000791600.1"/>
        <property type="gene ID" value="SPAL_0000791600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="611"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="900"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000791600.1"/>
        </source>
    </evidence>
    <sequence length="1174" mass="136280" checksum="E4FA6FB5F87494A5" modified="2015-12-09" version="1">MFLKLYWLGATLAMMPFLIQLEGLHRKDLFPNVPETINKTTFPLGLEVITDSDVVMVKCPDYKYKHNVSGYEIAPNLDIFKEEEIFRDPNNLFAWVPLLRQPTNQTKINCGNVQIKTGEDSIILKQWIFNVKWDDSAIDEIPVGTTIMDDSIPKTHVHCSSESEDVLIVSKNKEDNKAVKIDPKDIKSPYANQMFYYFKKSSENNKDSIKKPCFIYKGVKGCPIFNLPDYSEYSSIGEVKKIDINGLEGQKKKIRINLKKGNDEKFYRYEEISLSRMRYMKNSTEVIKGSTITITSSFVINGFDLVKLVYNCWTAQGNKTVSQTYYFGPGPINYTLDKTEEISANDTSIKVKCDTTYLNVGYLKEVEYNGTHANVNDLESTDSLRGKFSKGENSISFVESNNGTTVISCIYKTLDGSITTTTKFVNKDTIALNAQRLADQILNNITSQHNKTKMLELATMEKTFVKQIDKIKEESEENQKSALQKFSDKVGKTKAISLIVGVILLILIILAVPVVILYKKWLNPFLIMLKHKRKYPNVYVFWDNLTNESFDNYCKIIKDKKYLSDKVLNRKVIQKVEGGEEVDIGISHLFDETLVDCYKNLFRKIQAHYIYTDAEKRKYILSDGPTKDNQSSFWQMIYEEDIATIITIIYDKNSGDNDEVLKDLYWKKDKTTYKDIVVTCLDVIKVNVLSVSGYKIMLERKGSESKYLDIFHVSNWKGNEIPQSDLQFVNIYKEIIKNAPKKNILIHSTQGTGARVYMLTYFACIYDALISDRDIDCPMTVIKSIRDRRYGGNLVPYEFAYMIKALVTAFFNNRILIDFSQRRTDFTSSYDSYFYDYLKRRDKMDEVLKKFLEFVNIVDEGKMYEYKSVFYTLGRMDQNALPFYCKRYYDAIDNYLTGKDKKRYRYSDIQCLDANGITVNGKPAWDTESFIHANKFEYTTKNKITRKLILCQAPLDETIDDMLDMILRYKITLVVILVKPEEATGERKKWLPYFPEKDQSFETKNFRVSKLNFKGLDKDFTTETECNLKNKKDNSEMKFTLLHYQGWPDKSVPSEHMSIYSLYKRIISLRTGDYIGIHCSAGIGRTGTLALIMYLIDTINVFPTFDPIARLKCLREHRYLAVQKYSQFVFALMVVFEHYKKQINDMDAEAYEKFMTMAEKLVKKEKEIEDKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPU5</accession>
    <name>A0A0N5BPU5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPU5"/>
    <dbReference type="WBParaSite" id="SPAL_0000791900.1">
        <property type="protein sequence ID" value="SPAL_0000791900.1"/>
        <property type="gene ID" value="SPAL_0000791900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033094832" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="172"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000791900.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38393" checksum="351E40E17A7B6A69" modified="2015-12-09" version="1">MQKTFIIFLCIIFFSQIQPWPVFGGKNFFADDQNGKSITKSAMKTLDELLRRIKRFVSTINNPSDNFKEGKTNTTIKTFRDDDVMENSGLFDGDIRLSKKQAEYLIDTVAEVAEELGANVSDIVGDSKTRKKRKIDTRFDYEWELTIPYIINAGVDKNLVREALKKLESETCLRFQEHKVFPRGQAGLKYFPGDGCYSNVGRQSLNELQEISIGPGCNFIPTIQHETMHALGFTHEQSRADRDKYLQILINNVKDFAIENFLKLQLTDALDYGLPYDYGSAMHYNSYSSSKNGEPTMLPYNPLYQMTMGSKSEATFLNIMVLNLYNCEDICLNKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPV8</accession>
    <name>A0A0N5BPV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Astacin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000793300.1">
        <property type="protein sequence ID" value="SPAL_0000793300.1"/>
        <property type="gene ID" value="SPAL_0000793300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="6">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000793300.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35661" checksum="EFC5DA1331439F62" modified="2016-05-11" version="2">MYYYEDKVENLLKTKGYPDLKDIDKFFEQINENTCLKFTKSPTKFDKKKEKIGIFFIITGGNDHVKLSNDESKVTYIGLREETYSDIFKIRFYVGLALGLIPEIQRIDRDRELQVHDNDINDAFKLFYRKSNYYYKFLKDTDYDFASATHFPTYFGSKGLNSTYIPLQCQYKGMLKSNKHFVYSDLRKINSIYCKCLKRNSCKHGGYHHKKDCGKCTCPAMFIGDNCEKLIETKDKGCNEGQTTLTAKDYIQEVTIENIKEDCYISIKAENSNKVVQIFVEDAKIFNIKGSPMNPRGEIKYRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ91</accession>
    <name>A0A0N5BQ91_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ91"/>
    <dbReference type="STRING" id="174720.A0A0N5BQ91"/>
    <dbReference type="WBParaSite" id="SPAL_0000806000.1">
        <property type="protein sequence ID" value="SPAL_0000806000.1"/>
        <property type="gene ID" value="SPAL_0000806000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000806000.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19221" checksum="C88A301477C38B05" modified="2015-12-09" version="1">MQLQMCPNGTLTSTQGQLTGIKKDKSRVTLLIGSNILGDERKIIMIRKHLKPRCFKGKNISSNEYLQSQKAWMSRKLFFKIMLEWNTQLKKDERKILVIVDNASCHKLEQDEEIQLSQITLKFLPPSTTALCQPCDQGIIKCFKDKFRQMLIRRQIVFAENKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQI2</accession>
    <name>A0A0N5BQI2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQI2"/>
    <dbReference type="WBParaSite" id="SPAL_0000814700.1">
        <property type="protein sequence ID" value="SPAL_0000814700.1"/>
        <property type="gene ID" value="SPAL_0000814700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="141"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000814700.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31321" checksum="F017CEEE9F67D543" modified="2015-12-09" version="1">MGFKRGREFIKTEVKTAESILPFIDSRYQSSTFDLKEYELTHNGVYYCGKTVNKNLELVFQVAKVSKCHIKINAPSTRPMQKPCVVKPITPPKSFCISTAHGCMHYKYNKAFHYIWNEIWSTCSKNLRKGFTKMMKAKATEINRYRRFCGKTNLFIHKKLSDLAQRCANSMMSYQKSRKDITQRLTSNLHTQYGELRAYVSRGQSMLLMYILFGDAWTHNSNFDRPSERKWEMAQLMDKKTKYAGIGMSSSQNDVFVCITFSQISPYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQQ0</accession>
    <name>A0A0N5BQQ0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NEK6-subfamily protein kinase</fullName>
            <ecNumber evidence="10">2.7.11.34</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BQQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0000821200.1">
        <property type="protein sequence ID" value="SPAL_0000821200.1"/>
        <property type="gene ID" value="SPAL_0000821200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08224">
        <property type="entry name" value="STKc_Nek6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000821200.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34811" checksum="5B2CB5026BA351D3" modified="2015-12-09" version="1">METSQQYNLSSFEDEKKIGKGQFSEVYRAKRKKDGLAVALKKIQIHDMKDAKTRADCLREIKLLQDLKHPNIICYYASFIEGDQLIIILELADAGDLRRMIRHFRRNQRLIPERTVWKYFVQLARALNYMHSKRIMHRDIKPANVFITADQVVKLGDLGLGRFFSAKTNFAHSLVGTPYYMSPERIQEAGYNFKSDIWSIGCLLYEMAALQSPFYGDKMNLFSLCKKIENCEYPPLPGDVYSQHLRMLISACICFSPDKRPSAKEVLAVSEHLNSHFNCAKDSNLSDKNQLSSTGKKYVSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRU3</accession>
    <name>A0A0N5BRU3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18159"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRU3"/>
    <dbReference type="STRING" id="174720.A0A0N5BRU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000858800.1">
        <property type="protein sequence ID" value="SPAL_0000858800.1"/>
        <property type="gene ID" value="SPAL_0000858800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="51"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="414"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000858800.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="58044" checksum="21D6FB8111382C8C" modified="2015-12-09" version="1">MVSIEATAAFLKELETVSYYAKDEKQAVLSKATYLEHLSSLNITEPPHAVRKTAIICTIGPKCNTVETLACMIRNGMNVARLNFSHGDHSYHAMTIKNIREAAKVVKHENIVAIALDTKGPEIRTGMIMNSSTAEVELVKGKSIRLTTDPSFENTGNAVNLYVDYKNITNVLAPGKIIYIDDGLISLVVDEVGSDFVICTIENGGMLGSKKGVNLPGTSVDLPPVSEKDIADLLFGVEQGVDMIFASFIRNGSAVCKIREILGEKGKNIKIISKIENQEGVLNADEIIKASDGIMVARGDLGIEIPAEKVFLAQKLLIAKCNEAGKPVICATQMLESMISKPRPTRAETSDVANAVLDGADCVMLSGETAKGSYPIETIKIMHYICKEAEAAVYHSKFFEEILKRVKKPTSHVETIGVAAVSAAKSSLASAIVLCTTTGNTAAMISKFKPSVPIIAVTKNPQTARQLWLYRGVFPIYYSESEKLPDWTKDVDLRIREGINFGKEKGFIDTGDNIVVVTGWTSGAGKTNTLRLIIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSC1</accession>
    <name>A0A0N5BSC1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSC1"/>
    <dbReference type="STRING" id="174720.A0A0N5BSC1"/>
    <dbReference type="WBParaSite" id="SPAL_0000876500.1">
        <property type="protein sequence ID" value="SPAL_0000876500.1"/>
        <property type="gene ID" value="SPAL_0000876500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000876500.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24292" checksum="C861680F5A316D5F" modified="2015-12-09" version="1">MFWRRKYKAFIFDMAGVIMKYTNSHVAEDAQNPESNNLIEYMEALELGYYSIEELIKLFPSNHPLKIFASSIIDSNDLESASLILSKDEHFSRCIRKLRKKKYKIAMITNNFYIDKERKRTVLIKDISDFNVVVESCKVGMRKPNPEIYKYTLALLNVKPEETVFVDDLKINCDGANAIGIKTIHVKDGDTKSAVTEIKKLTKTKCFKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSI9</accession>
    <name>A0A0N5BSI9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSI9"/>
    <dbReference type="WBParaSite" id="SPAL_0000883000.1">
        <property type="protein sequence ID" value="SPAL_0000883000.1"/>
        <property type="gene ID" value="SPAL_0000883000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000883000.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21683" checksum="8A48AAD9DB22E242" modified="2015-12-09" version="1">MVDETGMHKILRALKDKERNRPPFRKNNGQSSYKNYNRSFHSNGSQSLHWDNNQRSTKGPKIPSVYKIFRIYSESDNSKDTDSQQFSKAPNNQQFSEGPDNQRFSKNHPDTGSETFDNSEFARRLRARNGQPLPSDFSEDEASTSHKSVAPYFRNQSSTNVWKSILRLFENFLRRPRRDQRAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSK4</accession>
    <name>A0A0N5BSK4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSK4"/>
    <dbReference type="WBParaSite" id="SPAL_0000884600.1">
        <property type="protein sequence ID" value="SPAL_0000884600.1"/>
        <property type="gene ID" value="SPAL_0000884600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000884600.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13795" checksum="126301FB3EBD3CF3" modified="2015-12-09" version="1">MVCRKTKSPENLWPKHYNNCHCISGRKKRCAVKLTVLMFRNLKGKIILQKAVVDKCGKLKANQTIFKQKEKELFLSRTYEYRKISFNKLSRSWMSNIHKGLRKMFNNHLYLRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSN3</accession>
    <name>A0A0N5BSN3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSN3"/>
    <dbReference type="STRING" id="174720.A0A0N5BSN3"/>
    <dbReference type="WBParaSite" id="SPAL_0000887500.1">
        <property type="protein sequence ID" value="SPAL_0000887500.1"/>
        <property type="gene ID" value="SPAL_0000887500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="148"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000887500.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="35106" checksum="9645B378A8B9A35A" modified="2015-12-09" version="1">MDYRYQYQPVIFNKKEKGYEATIYDEKSKSSFTNAFIVKYTTNGEVKYECKNRFFSTFQEALRYYRSTHRRVRFDKTTIQTFDPDSPPSAITHHNTNRNSIMDKKNDHNQVIWTLSLYMGSNYFSNQIWTRIWSDCNYECLFANNYLRLRQKLLREANEYRRAHNAKPLLEYSRMSREAQLFADDIARYERIFRDRNKKYGETVAKVYYELGPMVVKRWYDEIKYYFFKSIRTFKEAKDFSQLVWRKSRQVGIGVAECCRNKIIVVFKYYPKGNVRLLYRYNVKPRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BST3</accession>
    <name>A0A0N5BST3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2951 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BST3"/>
    <dbReference type="WBParaSite" id="SPAL_0000892500.1">
        <property type="protein sequence ID" value="SPAL_0000892500.1"/>
        <property type="gene ID" value="SPAL_0000892500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000892500.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8185" checksum="EB3DCBC01CBD3ADB" modified="2015-12-09" version="1">MKLADGTEINSDDAKKARASMIADMARRQREHEKTHDSSKAQWEYMKKLLTSLGVSISIVSIAIAIQYYLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT33</accession>
    <name>A0A0N5BT33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT33"/>
    <dbReference type="STRING" id="174720.A0A0N5BT33"/>
    <dbReference type="WBParaSite" id="SPAL_0000902600.1">
        <property type="protein sequence ID" value="SPAL_0000902600.1"/>
        <property type="gene ID" value="SPAL_0000902600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000902600.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40342" checksum="CC6B3C0ADB68C03B" modified="2015-12-09" version="1">MSTINSSTEFDGEFSRKKIIEKDNFTWTIEKFSLDELKTDEEMRSPVFDSKNNNRVKWSLFMSPEQVCSDKEDYISLCLELEDFECVELTVLCCFYVLRVDGEKKHKKVKSIQKLNNTADICFCNEFLKRDLLRSDDNELLSNGNLIVGCEIFYYCGPINTVTFLTGNNVNESLNLLMNDIAGMLESSKFSDCVIKVGNSKINVHKCILVSRSQVFDSMLTDKQSESNPNIIEINGFRLEVVKEMINYLYSGKSPNIDKMACEMLEIGEKYNLKRLKLMAEESLLYSMSVENVCDYLACSELYSGEILKGFCMRFIYLNAENVVNTEKWKKVVIDHPLLIANIFNIAVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTQ2</accession>
    <name>A0A0N5BTQ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTQ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BTQ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000923000.1">
        <property type="protein sequence ID" value="SPAL_0000923000.1"/>
        <property type="gene ID" value="SPAL_0000923000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000923000.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49950" checksum="AA0994D52AC3535D" modified="2015-12-09" version="1">MSISTIRRQMKNVACNYSDAQVKVREATSNDPWGPSTVMMSEIADLTYNPAAFNDIMVMLFKRLNDHGKNWRHVYKSLILLDYIIKCGSEKIAQQCRENIYTIETLKDFQHVEDNRDQGLNVREKAKQMVLLLKDEEKLKNEREKFQSTRRRFIQSGVGNVSNTTGVGRVSELEDARPSSIREEEIQLQIALALSKEEMKKEEDIRKGFQARLQHALEESKKDTSDFLSTDNNFTIPNTTTSAENNVEKKTPTNVIDDLLSLDFGESSVQSCQTLNSSPPTVNDPWAPIGNVPNNQNINVSNVNPWDIVTPNQPTTTDPWSTNNTNVNLLSNTDSTMSTNNDDKSLITEKNEPRKNSINVEHFLGPNSNLVNLDNLMGSTSNSTITRTSANPFLPISQQPINPFLAQQGTPLTLNELMQAEQRSQEKPNVQNSQNINNTFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTT7</accession>
    <name>A0A0N5BTT7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemocyanin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTT7"/>
    <dbReference type="WBParaSite" id="SPAL_0000926200.1">
        <property type="protein sequence ID" value="SPAL_0000926200.1"/>
        <property type="gene ID" value="SPAL_0000926200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894847" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000926200.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9362" checksum="31827E9D46A28AEE" modified="2015-12-09" version="1">MKVDKMMCFKILLLVIAVWNTIESKPHYLNYEAIARDLDTFPVIINKNVPMSPREMRFMALFNDELDKLQQNENLAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BV40</accession>
    <name>A0A0N5BV40_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BV40"/>
    <dbReference type="STRING" id="174720.A0A0N5BV40"/>
    <dbReference type="WBParaSite" id="SPAL_0000970600.1">
        <property type="protein sequence ID" value="SPAL_0000970600.1"/>
        <property type="gene ID" value="SPAL_0000970600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000970600.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37501" checksum="B5F19785A02DE313" modified="2015-12-09" version="1">MHFVKKVPTTEEQREVQEKEKALKAASYRNLCNAINIKLKNEVYDEELMNLSAQILEKNPDVYTLWNARKKYLEKVINENEDTTENDAILDGELTLAMTSLTKNPKSYSAWFHRFWAFKKMTKPDIKKELEMCRVALQLDCRNFHCWDHRRSVAEHAKLTPTEELQFVDYLIGKNISNYSAWHYRVTLLERLHYDNSGDIKNGKISEDTLLEEFNLVSNAYYTDSEDQACWCYVKWLIDASVKNMTPKIKNQINTVLQHIKELAELEPNNIYLLSTNIYILEKISGNKDEIVSLYEKLSNIDKLRRGMYLEKMKKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVU1</accession>
    <name>A0A0N5BVU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVU1"/>
    <dbReference type="STRING" id="174720.A0A0N5BVU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000994700.1">
        <property type="protein sequence ID" value="SPAL_0000994700.1"/>
        <property type="gene ID" value="SPAL_0000994700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF324">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000994700.1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="120364" checksum="A687AF1B5CDACB15" modified="2015-12-09" version="1">MSVNISESSDSNNSDWHSDLRHQIEELANKNENLKQYSFLGEKTKKMDQMIIELRHKASDSEVAAAQYHLKCLRFHDDMVRIVNQQTIKNKLRTLSARRKTIFQSQDSTGSNPPTDRSYNSSAYFYGPRKFDKRNNKNEEPKIQIRNNFLRLVCGLTEEDLNDDSHSDNGAEQDKKHVRDLWSTQITFFLSCLGFIIGVGNTLRFPSMIYEYGGGVFFIPYIIFLILFGFPLVYMHLCIGQYSGLSASGAFSKMMPAASGIGWGLVILAIPVCIYYNIIIAWSLYYFWYAITSPFSASYTDLAWNHCQKDWVLDHSCCEIKGDQKCFLKNGSMTSSEAFFHFEVLNRTLANNPSLGDVQMHTLICLAVAWILVYIGVSKGIGSIGWAVSITATIPYLLCLILLLRGISLPGSEIGLRFLFTADFSRLKSISLWKAAAEQVFYSLGIDAGPLISMASFSRYRNNIYRDAALLVILDTLTSILCGTIIFSFCGFLAKIQSKELTDILKLEPLYISYTVYPGITSFMEWGSFWAALFFGMLTLSALDGEFAWLEMIASSIMNLFGFKEHKIESRLHLFMCVLFFLLGIPLTCRGGIFIFHALEKLNANWNAFSLSLIQVILVCYVYGVDKFQEDIREMLRITDNYEEIRTIPYAIIRKWKEFKLFAGPTGSYIKYSWSIFSPLILSFLLIASIWRYERVTFSNRPLPIYYELIAWISMVGPLIIVPIIFFYHIRKLRKEGKKLSYIFDTSNWRVEDDDTYSQYSDEKNDDNFSSIDPISRNVSVKSNVFPSTSVIAQRIFRYPPHVPPSTIQEETGSHISGEELLNGPRFKKNSSFTTITETKKTVLEPIISSKNEKIEEEENISEHSNRITGRLADWLEKNEQQPELGIILFPKNETKNTTMYDIIGDKVENTGILFGPPPEKSSIASSSLITPISTKFPQDNGKKDKCIEHNHSLNLQTSSEKASPKCLRKKLSKQNKINEEGVNALDETNELNNYRDKIYLQNLAYEKNVTNVNIDDNAELAKSLLSKKEEIPLKTKQTIKLKRPKPIETPVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWD4</accession>
    <name>A0A0N5BWD4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWD4"/>
    <dbReference type="WBParaSite" id="SPAL_0001013100.1">
        <property type="protein sequence ID" value="SPAL_0001013100.1"/>
        <property type="gene ID" value="SPAL_0001013100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="343"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001013100.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="88396" checksum="18E324E22E47B2F0" modified="2015-12-09" version="1">MPPFNNSHQLALLCTDNNHKFIYTDRMHGAMTYLFQSNDTHQICMNNNETKINPKYEGLIWLITSLQSCNVIRKIKSRFSREKYNSNFHYNFLKASFALVCQKTDDIGVYQLQFYADIFRILFERRNEDRKLICQKVVALYNEMYERCHVMNKTDFMKSVMNICNIRGGMIRVNIFFQRFARNCDTPQEFFINHNQFLYKGFGQSLTEDNIFMNSLSAHLTSTIRGKSILPHLMLKTRLLLQHFSLAAMTVYREIEKVMKCNKIDKKVNHMFEEEILQNGLLYLNQTTNDENFIETSDDYNEDCNTTDSIYFDLIESKNYQNIGSQALIGVYVEICLLILVIFNTLCLSILLYQTQSHLSTATILFIFNILFSNFLFVSSFGILFSDLLSENPYAPLSDTTIGEEKSAAYAIAETLQSHLFAPSQFYKHLVQETLFSLSQNGSLLGLTHLLVLVLVVISKSMSGKAIRLSKFCVITVFSLVWIFLIITHIIFSLLQISAITYLDNLLDGVSSSYRRYEFECTNKDRHFSHYNDIGQRCDRVEPYHRFGVYLLRGHTLFTLIFLFVALIVFVVTLFYHWKVRHQNGVLKIHQHNDGSPHKRRETLFNTLLLSITAFFISVLGQTIIEISVFWLENPDEVADFARWYQVMRIASFVDPLLNPLLVSVRTPVIRRKLRMMLYVLGQHFITCCCPWKIRNVNRRSKKVRKSKKASITTADSASIYRPTDSEVTFRIWCTRQYVRTSFFGKFTNSQGVTNHSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWH4</accession>
    <name>A0A0N5BWH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWH4"/>
    <dbReference type="STRING" id="174720.A0A0N5BWH4"/>
    <dbReference type="WBParaSite" id="SPAL_0001016900.1">
        <property type="protein sequence ID" value="SPAL_0001016900.1"/>
        <property type="gene ID" value="SPAL_0001016900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000099">
        <property type="entry name" value="Tropomodulin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001016900.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46977" checksum="F4E3AF29CA284CF5" modified="2015-12-09" version="1">MSPSDFLTKDQLHDSTKVQKKGSLKSGIGLYGHDMNGFDDAELEAILSNMSPEELEDLNCDFDPDNSLLPPSQRCRDQTNKAPTGPFDRNKLLKFLEEEAAKEKDWEEVVPFVPGIKRGKVFEHKVEEETKTSSGINIIGISEENKEKTETNIEKKAKGMEMPIEVDLDEDSEDGEEEDTDLAEALHKAPERDLVDLAGILGMHNVLNQEQYYNALKGKGQDDGTGTSFGSVIRGFEPRIVQDEPENQTNIEECINKLETNDPTMKEVNINNMKSISKERLRCLIEKATKSSYLTKLLMANTAMSDSEARGLIELLETSTSLKVLNIESNYITPELMAKLIKATLKTQSLTEFHAENQRASILGNQIEMDIMMNIEENDSLLRVGLGFQSMEARHRVSEALERNYERLRLMRLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX75</accession>
    <name>A0A0N5BX75_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beclin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX75"/>
    <dbReference type="STRING" id="174720.A0A0N5BX75"/>
    <dbReference type="WBParaSite" id="SPAL_0001041000.1">
        <property type="protein sequence ID" value="SPAL_0001041000.1"/>
        <property type="gene ID" value="SPAL_0001041000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="4">
        <location>
            <begin position="66"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="3">
        <location>
            <begin position="198"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001041000.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45456" checksum="1CA744A5DDF1ED39" modified="2015-12-09" version="1">MSDSQNIDPKSFCCNCKEELVIHESIFDNDSLKLVDLTTLNNSKLSFAQGNTIQMIAKSDSPSHVPMCKDCHALLVDDLYLKTKALESQNNSYRQCLLRVTESEEVILNEETEKEKFLEELQVHEQRLIDELNKLEKEEAFLYEEISNLELEEEKVRVESNKLFGQLKNYHREMVNLSLKKLSTKLQDVVAVDQLNDLLKTNLLNKTFFIDVNEKDVGRINNLQLGRLPDNSIPLNEFNAAWGQCVLCLQVLFDLLKLNSYPYQLIPMGCQSMIRETTESGVKDYKLYESSWGIFKPSIDDGILAFIKCLLIFEAEFCSKNDTKTMTIYPFTMKNDKITEEHVTLETESSVIWYSVKMQFQKDERWTKSMRLMLLNLKTAIMFTSSVKKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXM7</accession>
    <name>A0A0N5BXM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXM7"/>
    <dbReference type="STRING" id="174720.A0A0N5BXM7"/>
    <dbReference type="WBParaSite" id="SPAL_0001055100.1">
        <property type="protein sequence ID" value="SPAL_0001055100.1"/>
        <property type="gene ID" value="SPAL_0001055100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF5">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001055100.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40702" checksum="8332355523809BC3" modified="2015-12-09" version="1">MFINCFFLSMTEETESSGYTFQDHGDNCVIWNDNVIDKEVEEFKNGLKSPVSTKNHSYDRKDKCIKKKVKKEESQQFNSKHFIFLRHGERLDYVFPEWFEDMVKTKKYIFSDLNQPDSLSHLNRDLGEFKLDTPLTNTGSIMSQLVGKNLHENNLVPDYIYCSPALRCIQTAALIRIGSESKALIRIEPGLYEENIWIGKCDGTSPCMTMEQLALSSICGIDYDYKPFVKLSKLFCSPENYNDYNARLQMTIDKLINNHDKDESKSPKTILIVGHASTVDVAVGYFSYPKRKITKEEGKDVTKFIPYHGGVTIERNKKGDWKKNFKRLKCYSMYQFDTACDIKFMKRDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXU4</accession>
    <name>A0A0N5BXU4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXU4"/>
    <dbReference type="STRING" id="174720.A0A0N5BXU4"/>
    <dbReference type="WBParaSite" id="SPAL_0001061200.1">
        <property type="protein sequence ID" value="SPAL_0001061200.1"/>
        <property type="gene ID" value="SPAL_0001061200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001061200.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13892" checksum="12815F72BDE5E6E9" modified="2015-12-09" version="1">MSASNLKVSKEDQAKINKFATGHAKSVSLKREIEKLKTFLENCKEAEEEIILVDSETIPYKVGNAFFELTLDEINDQLAKDIELNNSKLTEKQLALEKVTSELNGLKKDLYAKFGKAINLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYB6</accession>
    <name>A0A0N5BYB6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYB6"/>
    <dbReference type="WBParaSite" id="SPAL_0001077700.1">
        <property type="protein sequence ID" value="SPAL_0001077700.1"/>
        <property type="gene ID" value="SPAL_0001077700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001077700.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13502" checksum="5DF5FC50914E1145" modified="2015-12-09" version="1">MGKADNRNGGSGIVIKKELLKYIQKIVTQSSRITSIVMKVENETCVLTSCYFHTSAASEDEIDILYDKLRGIITDSKDRNMKCIVGGDFNAKVLFNNKNGRRLNGNVLENERGERLTQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYQ7</accession>
    <name>A0A0N5BYQ7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYQ7"/>
    <dbReference type="STRING" id="174720.A0A0N5BYQ7"/>
    <dbReference type="WBParaSite" id="SPAL_0001090600.1">
        <property type="protein sequence ID" value="SPAL_0001090600.1"/>
        <property type="gene ID" value="SPAL_0001090600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001090600.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35026" checksum="5EBE429407A88EB3" modified="2015-12-09" version="1">MTENSKYRLVVLGSSKVGKTSIIRRYLYREFSEKYKETVEDLHSRRFMIHGSELNLDILDTNFNFPDMRKVAISSASAFMIVFSVDNVQSFKEMSDLWNEITSIRSNISNIPTVFVGNKSDMESKKIFEATANAWVSRLNSKVKYIESSAKNNINIVKIFKSLLDLSGFESKALAEQVELQNAALEVKAHSSGGFLKRVGSTKRNNQEGKAIEKVVCEGTATPIVALTTQLSTPTLGITGDLNILRRNCSLRINPGKEKHNKEINKLSENDNKAISRSGSIIRRTKHLSLKVRKSNDRALTQQIDESDCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYX9</accession>
    <name>A0A0N5BYX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYX9"/>
    <dbReference type="WBParaSite" id="SPAL_0001097800.1">
        <property type="protein sequence ID" value="SPAL_0001097800.1"/>
        <property type="gene ID" value="SPAL_0001097800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001097800.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43491" checksum="84718C25F86CAF27" modified="2015-12-09" version="1">MDISEENNMLFKLLKINLIRKVIIKHIPSFTDINNLVNVCKFMNCGLEKENIERSILSYHDIQDIWVKNDHVHEYDKASSVIRLNNFKFTKSYYSESLRDRLRTFFGETLHIGSCVWSSIDLSINEWKEEDYVPFIQKLTEELNLNCATRKDVRKLKFELKFRDNADYIILDVLSHIKHDNIKRISLPVNCFTCPSNKYNVINCNIFNGFPNLTELSLDFSFSRSDYYDLAYHKDIFERFVQQFSTAKNPTILFESLEHEDAMRANELNEIINSITKYNVKVKLKVNIEYYKFIGECEKCADTMGFFSPVKQYITIVYDSISDYRRLLYSVEILKTFENLSTLDLKFVLPAITGNFTPSYNQSQRFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZB4</accession>
    <name>A0A0N5BZB4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BZB4"/>
    <dbReference type="WBParaSite" id="SPAL_0001110700.1">
        <property type="protein sequence ID" value="SPAL_0001110700.1"/>
        <property type="gene ID" value="SPAL_0001110700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="11">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="474"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1302"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001110700.1"/>
        </source>
    </evidence>
    <sequence length="1385" mass="159237" checksum="E04F1D415C56FCE3" modified="2015-12-09" version="1">MKCILSGIDDKEKVSRFIRCLEFNSFTKIRAQLINDGKSIETIKIDDLYNSFTKTFGGKTRFSNIVNLITNGKSYSDAGDLCTEITLAVEDFPREVISKSELSGLVFLMKFKSDNQALESALRKKIMDTCESKEMVVKSESKDEKGKDIEASIKAVQFPSSTEFRDCISYFKSLVREEVHEEVSVNKINNTRRHNDNFKKNKVNQVKKKSNGCFRCGSKYHRIKDCKMKAKRVENFVSSSSDSEESTEYEDDTTEINSVRIIKKVNVIDVNTVKLNTNTMMLNVEFWNDDIKWKQVIGADTGCPKTILPDNLVPKSIQRNPSKIKYVTGVSGGRLKVTGTTTLNLTILGKNDKKIHSLSEVLLIKGLKYGLLGRNDLIKMGLVSDLKDLCVNNTLELEKPKNHLINIDHERKIMEQQFSQKFSELLSDTPGRVKDAVVELKLKDNCKFVKVPSRDYSCIAAEEAINKKIDFYIKHEIFEPTLYTRACSPLIPIVKDSTKPLNESNIRFVADYSLVNKNFEVPEVRLPTVESELWKISKVKKNGKKLYYSKFDLTEGYTSLPLKETCHDLCTISTHRGLMKVKRLPQGISPAPALFQAYMTTKIEEMLKILNNKEKYDVCESNFQILNMMDDAVIVTNDIITHWQVLKVFGQVLQKAGLRLNKKKLFLLREKIDYLGVTLDIEGYRPMKDKVESIMKMKIPTTRDELRSILGMINVHTEFVPGLSTLRHSLDLLNRDGQFRQLNSDEIKCIETIKKEIAKEIKKCIFDPNEIQKIIVESDASTMGIGGVLKGEVYEYNPKKGIKEKKTKIYGCFSRALRGAEKNYPIQHLEGLALVESILRFKKYLLFRKFYVHTDHKSLESVFDISKKGISKTTCSRLTRWLLKICIFNFEVKYTNNVHTADCLSRLLDEYKNSLEEKELVIGKTNEVMVTKKLDLKENCIDTNEIKIIAKTDVQYQKWVEILKSNGTIDEFKTLKNDMYISNELIYIGDRILIPDQLKEHIVEMLHKTHMGARLMKQKARKEMYWIGINKDLEKAAKNCIECSRYERLPNKSDPIPWEEPKEPFSRVHLDIGQFYESNTEFICATDSKTGYVDAKILKSKKSCDVIKFLQKIERTFGEFDVIVADQGRYFTSNEFATYINNKKTQLLFCGTAHHEANGLAESTVKILKERARKMLIHEKSTLYEKKNILNEILQALNKTPRGTRPESPYSLIFTYNRDKLIKTKLDTDKSGKFEIDETVRFKLPFDKEYKIGVISERIGSSTYVITSNNRQYHLHSNNIRKNRGGKSCNFTKSSDIWLLDSNDSLPKKNSNTNKPKKATRMKDSSSKNIENLENQIVDMLKKPPTNPRIPNRPLQVSLRNKGTPFSMSYSCNSSNWRGMLGNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZS8</accession>
    <name>A0A0N5BZS8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZS8"/>
    <dbReference type="WBParaSite" id="SPAL_0001126800.1">
        <property type="protein sequence ID" value="SPAL_0001126800.1"/>
        <property type="gene ID" value="SPAL_0001126800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001126800.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29939" checksum="3B6B4F6A0876E5C0" modified="2015-12-09" version="1">MNSSENVDEIRFLRAFYLHSSELDELYNFLQKVDLTSLDLVDISLDNHTEIIRIFSDYFHNHIRINSIYVTSTNCEKDFGNTLSFLEKIQNVGHLELNLRFPHLNVPKDYIIPVRNSLKSIIIQEKANTVFVNSRMIEYIVENNPNLDEYHLFLNNFENYKMIIETVVRRKLSRRDNLCFHKSISLRFGISSYEAFFELSNYDYSENLPYNHSRIPNLPFDNGIEITFYNGYLECPVCGEFDSIKICGRTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C030</accession>
    <name>A0A0N5C030_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C030"/>
    <dbReference type="WBParaSite" id="SPAL_0001136300.1">
        <property type="protein sequence ID" value="SPAL_0001136300.1"/>
        <property type="gene ID" value="SPAL_0001136300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001136300.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27240" checksum="501A2ADC1E1A5BEC" modified="2015-12-09" version="1">MGCAQAKIQQDTSIDNEINKKSTVSNDCLKANHDFERRPSTNSKTKSHHVKFTLTKDEKSIIQKNWESTVLVQIPDLFLKTMLNSIKESPKLLDVINCRMGDANIADLAEWPKLKGMAKGNCNFFTKQIVENHLEEPLVRKDSEVLGAIHIKYSPYGFKPTFLDIWHNNILKLIKDEVTFENDNEKEKFLSAFTKLAHFLITILIVEYEDHMKSVRLHDREVSRSQNETSTSGSNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0A3</accession>
    <name>A0A0N5C0A3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="STRING" id="174720.A0A0N5C0A3"/>
    <dbReference type="WBParaSite" id="SPAL_0001143200.1">
        <property type="protein sequence ID" value="SPAL_0001143200.1"/>
        <property type="gene ID" value="SPAL_0001143200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001143200.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12933" checksum="583E2BF4F1DA84C5" modified="2015-12-09" version="1">XKPRKIQAFAIPIIANGFDLICQSEAASGKTGAYLLPIIDEMLKSEWKSKNKPKTPYGMIIAPTRELVIQISEYGRKLYEETKLCCAMLYGQKTKDFFKHIKSNPSSTIHMIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0E6</accession>
    <name>A0A0N5C0E6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0E6"/>
    <dbReference type="STRING" id="174720.A0A0N5C0E6"/>
    <dbReference type="WBParaSite" id="SPAL_0001147500.1">
        <property type="protein sequence ID" value="SPAL_0001147500.1"/>
        <property type="gene ID" value="SPAL_0001147500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF14">
        <property type="entry name" value="RETROTRANSPOSON COPIA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001147500.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34384" checksum="A39B3CB3992358DF" modified="2015-12-09" version="1">MADVKSPNKVINISEVVKIMRGLSITKLVNQENFLLWKEDFSTLLECLSWKYEDLKDKNLSTGCSAKIIRLTLSDDLKREFLYTDNSFDLIKDIEMKFKRTTIIDIINLKSELYTFQETDPMTMISRVKSVVMQLKQLDQIINDTEMCHIILTKLDAKYDMMKTTLTDSITLEDLVQRIKSQSDAMVTNDISETSFYVNKKFSSHNRNKNYQIKRNNVKSQLCYNCRGTGHQAKVCPSPSNYVNFSVEDDVDNIIDEDSDYGFFMGTIASMAQTMESLWIIDSGASVHITNEKSKLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Q0</accession>
    <name>A0A0N5C0Q0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Q0"/>
    <dbReference type="STRING" id="174720.A0A0N5C0Q0"/>
    <dbReference type="WBParaSite" id="SPAL_0001157800.1">
        <property type="protein sequence ID" value="SPAL_0001157800.1"/>
        <property type="gene ID" value="SPAL_0001157800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001157800.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17345" checksum="66C06496D6783164" modified="2015-12-09" version="1">MGKLFRVSLSFIQSCQRFASKKVVKMPKFSESKAYQGFDKYRMNEKLISPPIDTSYYNSSSYRNKVILSFLLSELTLVIYIAFLRGENEFDKVFNTPFYVLSLNSERSTIRYEIDKARAKGEDTKLLEERLAYVDIKEAAAKARFEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0Z6</accession>
    <name>A0A0N5C0Z6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotid_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0Z6"/>
    <dbReference type="WBParaSite" id="SPAL_0001167500.1">
        <property type="protein sequence ID" value="SPAL_0001167500.1"/>
        <property type="gene ID" value="SPAL_0001167500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001167500.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45833" checksum="CEACEDF19A865790" modified="2015-12-09" version="1">MTPRLWNLLKVICITFLVALTYFVFILLFNYYYKQYYTSNYKLSHGEERCVEGGQNSKDGNCKINKFNKLVFDGNVIVKIENNIYPKIGSNIKFLLQSVSEELINKDAENIHKSTSMTSNTYKNKFIYVTIVTTSTKLYLKNWLCSIYGLEKKLTDSTVFGKVLLISLDSDLCQEIIKEYKLLCLYIPAGDKSNSEIKTIDMLRKWNIFVVDLLKEIVDQGINVFYFDTNTIWLKDPLTLINNTTLIDDADIVLPIKEALDQPFRFSPSPILIHSTEASKNFLSKIILHLKSFNKDDLQSNVINEVINELCQEMYYGIVCREFSREDVCDMRHCSDSRLPSGKMNQTIIFNDFDVSINNSQRYNFIRRRRMWFLNSYHNGSNKCLISRIKEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2C7</accession>
    <name>A0A0N5C2C7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GPI transamidase subunit PIG-U</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2C7"/>
    <dbReference type="STRING" id="174720.A0A0N5C2C7"/>
    <dbReference type="WBParaSite" id="SPAL_0001213700.1">
        <property type="protein sequence ID" value="SPAL_0001213700.1"/>
        <property type="gene ID" value="SPAL_0001213700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001213700.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44909" checksum="4E9D29794FBFD208" modified="2015-12-09" version="1">MKGENEIWKFISFPILQPLSLSILLKVISYKFWYDYLAKCPEFVVATNSFERLKEGVFLKEIGEDPYDGDIFHMQPLLLLLFKYVVWFPSGFLVILLIFDTCTAFILRKISDILTDGNEQIKNLVFILFLLNPMAIGTTAVLSTSSIFNFFVVLSIYYYLNNESEKYTSLLSFLTTCNIYYFTLFGPMIVKFPKKKILLGIVFILSFSSIHGLNYMLSGNSFQYLQSTYMFQLKVPELYPDVGLFWYMFCEVFLHFETFFLTVFQIHIFIYMIPLAITLKKYPFLLLHVSLIIITCFSSYPSYGDAIVYLSLLPTHHNLFMKIRKSIIIFGALVACLVLFPTMWTIWMIYNAGNANFYFSLTLVYALVHIFIASDLIYAQTSITHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C329</accession>
    <name>A0A0N5C329_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C329"/>
    <dbReference type="STRING" id="174720.A0A0N5C329"/>
    <dbReference type="WBParaSite" id="SPAL_0001238400.4">
        <property type="protein sequence ID" value="SPAL_0001238400.4"/>
        <property type="gene ID" value="SPAL_0001238400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="413"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="553"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001238400.4"/>
        </source>
    </evidence>
    <sequence length="972" mass="112745" checksum="8067A55B4741D264" modified="2015-12-09" version="1">MGIVAPSITFFTWHHARLVALILNAFSGILFYTENQVQQKNKLEKNEIFMLHLIDKQLDIYQKYYYGNGFHDDIFNGMKEISEKARHILKSNHNDFLTFLNSKDFTIQLEEYKLTDERLRWDLKDLPNANRREIINGRGFTFWFDNSCFQELLGNISSTCFKEYSNYKGLIEFDLTSRVQYLLYGRKFAENYFNHHLKIGYNSIVNEICANMQDEFSKHKQNHYKNLIKLGKVQRDLLMNQVFACGQFGFLEISDLHILTSILSWQHPSLGCFSREIPDNLPNYGIARPDLKSQQSSPSNLCDSDSNFLGVYALMVYFRLLLEPPFKFREYNLPEQPVYMGHISAEDKFKQFKYKDWVRDAGFPKELRIPKPEPIYCDNVIIPDENSGPSNKYEEEVSNAVNNTSIEETIEGSQICLICGDTAAGKHYGVVACNGCKGFFRRTVRRQYTYSCRYQGRCDVNKANRANCRYCRFKKCKDHGMRVDAVQAERDLIGKRKKSQEILNSFDSIYNTPVKHMKMDNDSSGRTPFNNIQYSSSNIYNLQYPELPYRYSNPLDVIRYMIESEDMASAKLDWSSGKDILKDLCKCENIMQHQKNSGIKKSNCYYNTKEYQQLVKEDGKVISRLEVLETLREMFQLTIHWSKSLQPFNKLSDDDKAILVKNFACQHFMLCLGYRSMFNEEYLNIINDCIIEESIDYKQRNYCTNFLEKTMKELVEEMKRLQMDDVEFVAIKAASLFNNTCEGISKDGSNHVLEIKRSILKALTDYINNKITSESTRLCDLLISIVTTSKVLGGVLLENFIFKKILGISQIDNLIQQFILTNDTANDEDVSEMGNIDKVQLSNVVQNDFSTMSPTNDTQPLALYKIINQNSNQVDHQHCQKQQGIPGYPFTGAFDSIMTPQMPMKDINNSYFNGLKTNDYINHIQGYQEMEGIKNQHISSHTFVNTQLLNSWSVTNVQDHFLNGPSDCGRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C359</accession>
    <name>A0A0N5C359_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C359"/>
    <dbReference type="STRING" id="174720.A0A0N5C359"/>
    <dbReference type="WBParaSite" id="SPAL_0001241400.1">
        <property type="protein sequence ID" value="SPAL_0001241400.1"/>
        <property type="gene ID" value="SPAL_0001241400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000084">
        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001241400.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42497" checksum="0D14B0DF9831E2EB" modified="2015-12-09" version="1">MFLLRSNNLIGTLSGKNKFLFNSLRLCSSNFAEAQKNLKKLREEPDNDVKLKLYGLFKQATSGDVSGSRPGMMDFVGRAKYDAHKEAFGLSREEAEKKYVDLVNSLLKEEEKVSNDSTTSSSSSINVPGIDITKEGKVYKITMNRPKKYNALTLEMYDAIGNALRESNNDSTTSVTVVTGTGNFFSSGNDLSNFANVRSVEDIKAIGEKASKIFDNFVTAFIDHDKPLIGLINGPAVGITVTTLAMYDYVIASDKATFETPFHKLALSAEGCSSYTFPLLMGHLKASEMLIFGKKLTAQEAKERNLINEVVPYTDFMMASDKKVKEISSLYPEAMKINKKLLRDIHRAKLHEVNKVEIPILFQRFASKESMNAISNFFSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3H8</accession>
    <name>A0A0N5C3H8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3H8"/>
    <dbReference type="WBParaSite" id="SPAL_0001252425.1">
        <property type="protein sequence ID" value="SPAL_0001252425.1"/>
        <property type="gene ID" value="SPAL_0001252425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001252425.1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7684" checksum="97FB0765E33D24F0" modified="2015-12-09" version="1">MIDQLNVKRLCCSDDKKYKQIRFLDIDKDITLSDIEILKKTRFHTYEFVMNTTKKELISIGGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3R5</accession>
    <name>A0A0N5C3R5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3R5"/>
    <dbReference type="WBParaSite" id="SPAL_0001260500.1">
        <property type="protein sequence ID" value="SPAL_0001260500.1"/>
        <property type="gene ID" value="SPAL_0001260500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001260500.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17757" checksum="047EEFA86E122140" modified="2015-12-09" version="1">MVTKKEGIIELDNGEDQMSTTGLHTSTPITTTADVSLSTTEISTEKMSITTLPNVVTTMTLHPLITKINSSEKISQSTSLDVVTTKTIFPVITEKIIPNEGKKIMIPPRALSIYLKVLGDLKKHNLQPFPDTVKQVHNYRETLINNTIRLEDDIKKLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4N0</accession>
    <name>A0A0N5C4N0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4N0"/>
    <dbReference type="STRING" id="174720.A0A0N5C4N0"/>
    <dbReference type="WBParaSite" id="SPAL_0001291000.3">
        <property type="protein sequence ID" value="SPAL_0001291000.3"/>
        <property type="gene ID" value="SPAL_0001291000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="543"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001291000.3"/>
        </source>
    </evidence>
    <sequence length="585" mass="65100" checksum="9406F2B065E98DA3" modified="2015-12-09" version="1">MDTSSGASNSGSANAAGSSNNTNTSSTTGSSSVTSNKASASSRTAIDKEKCVERFIKSVQFPVSERLTIEDVYDKRTGKPRSDVLKEHFIKEGRIEEDAAIKIIQECTALFRQEKTMLDIEAPVTVCGDIHGQFYDLMKLFEVGGSPANTKYLFLGDYVDRGYFSIECVLYLWALKICYPNTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDVCMDSFDALPLAALMNQQFLCVHGGLSPEIHTLDDIKKLDRFKEPPAFGPMCDLLWSDPLEDFGNERNCEQFSHNSVRGCSYFYSYAACCDFLQHNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSQHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELLTDSDDTFEGGIPAARKEVIKHKIRAIGKMARAFSVLREESETVLQLKGLTPSGTLPMGTLQEGSRGIHKGISENETVVQLKGLNPCGKLPQGALSGGRQTLEESLHGVEPGHRIQSFDEAKRLDKINERMPPTMSYGAAGSSGNSPSSSPQPRKPNMPPSSTSGSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C510</accession>
    <name>A0A0N5C510_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C510"/>
    <dbReference type="STRING" id="174720.A0A0N5C510"/>
    <dbReference type="WBParaSite" id="SPAL_0001303700.1">
        <property type="protein sequence ID" value="SPAL_0001303700.1"/>
        <property type="gene ID" value="SPAL_0001303700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001303700.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28911" checksum="D9265FF73DDDCD1E" modified="2015-12-09" version="1">TPFLQHLAPALMNRVFCYHGFPKTLRSDGGGNFRSEEFGKWLSQLNIVHEMSAPHHSQGNCLVERTFKWIADTVAKVARERPNYWPEYLPMVMFYYNSMKNATTGCSPFMLTHLREPNCLLDQFIGSYSTGIFDSSSSIYDMMERAAIVRESAKHAIEATRSEGNKNNGHHDIPKYDSKQLVLVKMNDVEKDVGSKFKFLYQGPFFVTRQVDEKVYYKKKGSGKEHVAHITNVKPFYKDLLDSYLAKISNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5A0</accession>
    <name>A0A0N5C5A0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsid protein (F protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the microviridae F protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5A0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5A0"/>
    <dbReference type="WBParaSite" id="SPAL_0001312800.1">
        <property type="protein sequence ID" value="SPAL_0001312800.1"/>
        <property type="gene ID" value="SPAL_0001312800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:symbiont-mediated perturbation of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.169.10">
        <property type="entry name" value="Microviridae F protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016184">
        <property type="entry name" value="Capsid/spike_ssDNA_virus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003514">
        <property type="entry name" value="Microviridae_protein_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037002">
        <property type="entry name" value="Microviridae_protein_F_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003515">
        <property type="entry name" value="Spike_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02305">
        <property type="entry name" value="Phage_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02306">
        <property type="entry name" value="Phage_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88645">
        <property type="entry name" value="ssDNA viruses"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001312800.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="63584" checksum="FB2CAA345B4897BF" modified="2015-12-09" version="1">MSNIQTGAERMPHDLSHLGFLAGQIGRLITISTTPVIAGDSFEMDAVGALRLSPLRRGLAIDSTVDIFTFYVPHRHVYGEQWIKFMKDGVNATPLPTVNTTGYIDHAAFLGTINPDTNKIPKHLFQGYLNIYNNYFKAPWMPDRTEANPNELNQDDARYGFRCCHLKNIWTAPLPPETELSRQMTTSTTSIDIMGLQAAYANLHTDQERDYFMQRYHDVISSFGGKTSYDADNRPLLVMRSNLWASGYDVDGTDQTSLGQFSGRVQQTYKHSVPRFFVPEHGTMFTLALVRFPPTATKEIQYLNAKGALTYTDIAGDPVLYGNLPPREISMKDVFRSGDSSKKFKIAEGQWYRYAPSYVSPAYHLLEGFPFIQEPPSGDLQERVLIRHHDYDQCFQSTFISRHNSNFFSDKLVLTSVTPASSAPVLQTPKATSSTLYFDSLTVNAGNGGFLHCIQMDTSVNAANQVVSVGADIAFDADPKFFACLVRFESSSVPTTLPTAYDVYPLDGRHDGGYYTVKDCVTIDVLPRTPGNNVYVGFMVWSNFTATKCRGLVSLNQVIKEIICLQPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5D4</accession>
    <name>A0A0N5C5D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5D4"/>
    <dbReference type="STRING" id="174720.A0A0N5C5D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001316300.1">
        <property type="protein sequence ID" value="SPAL_0001316300.1"/>
        <property type="gene ID" value="SPAL_0001316300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF25">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895381" evidence="5">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="28"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001316300.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20402" checksum="23D6150CA1E5306F" modified="2015-12-09" version="1">MTNFFTKFLTFLLLFNESYGYFDQYCYCTYTPDVVLFCTSCWISHVKIMNKTIVQANSNSHEPFSYTNSVKYEIEHIHVLKDTISDNNSTLPNFVLTPQSFHECGLSWLEEGEEYILTGRASHTGTLLVSLCDGLNFNDNKNETIAKINLWKKIIPCSDNSNDTLHSHQHKYFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6U3</accession>
    <name>A0A0N5C6U3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6U3"/>
    <dbReference type="STRING" id="174720.A0A0N5C6U3"/>
    <dbReference type="WBParaSite" id="SPAL_0001365800.1">
        <property type="protein sequence ID" value="SPAL_0001365800.1"/>
        <property type="gene ID" value="SPAL_0001365800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000097">
        <property type="entry name" value="Bent, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="112"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="330"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001365800.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="57693" checksum="75F33B74E9B38F60" modified="2015-12-09" version="1">MPGAPRFIQKPSIQQTPQGDLLMECNLEADPLPEIVWHHSGTPIVAGGRVQLSIQNVSGIQYKAILIIKEPNAGDGGTYKCTASNQLGESNANINLNFAGGSDDQKGSSKGPTFIGKPRIIPKDGGALILMECRVKSSSKPTAKWSKDGALLPIGGLFQDIFTDLGDNAYLCQLEIRKPSANDAGQYRCTIKNDQGETNANLTLNFEQEPTQDDKIGRRSPSVNKDGRKSRTPSRPGTPHKKKDKEKSERNKSREGTPKKSTRSRTATPTKELRDSEKMDVDGTSVKRRSDAPLPPKEKKSRQRSISPAVSEQASINSQVKSQSEAKNIPVVVEHIKSQTINVGDSTTITCKFQCHNSTKISWYKDGKVITSSSEYTQAFDGTTARLSLNRVTQNNSGIYKVVAKSEYGEAESSAKIDVEQKSKDDNLLDVKPNSRRASRDSINTDKSESELTSIYQKRNKSSVSPAPSVQSLSELEVPKKISRKGSAVESEQEKSLISESAKAPKSRNMTTKDDVDESSVVEDVSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C843</accession>
    <name>A0A0N5C843_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RTP1_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C843"/>
    <dbReference type="STRING" id="174720.A0A0N5C843"/>
    <dbReference type="WBParaSite" id="SPAL_0001409900.1">
        <property type="protein sequence ID" value="SPAL_0001409900.1"/>
        <property type="gene ID" value="SPAL_0001409900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="3">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="719"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001409900.1"/>
        </source>
    </evidence>
    <sequence length="980" mass="112793" checksum="DB35D644888FAFF6" modified="2015-12-09" version="1">MQTSLKLLDFVTTFHDVKVSKNSIIKFDPIDDAFCRGLEKFKETGCIKKFEEYSNAFQEYISISQDPRINFSILLLYLYDDFLEEVRNDSNITDDLCLSVEGEKILLKSLEFFISVAIYPCLEDGVGVPITKLLRVPMKEWKKYNDLNVRKILLHKSIELLFKLLNSNKKIKFIVLEKFLAIFISGNEQLVHYGIVNFKEDYNEVIENTVNSVSVFKALFAQYTNKDSPKWYRIVCGCKLSKFLCYKRGLTNFVTAIENLTDIKFFENSVGMNELAKLLGSCPSSVSLEDYYKNILEQLFDLLLFSQEWTRKFRLMFGSLIDIVFKKEKKIVDKFFVYRVLNPWTILLEKGIQLDHDTNRGLWSVEIDQSFVLLETYLTTGKGLLRKFLCSEIIEKGFFYLWISLTSQLEDDLPFRKALKNILFGVIDNLTDDEKCKLFFDILLKRGKISSIVNTSKYFKVDTFKKSNLIESEQSNFHFDGILLNILDSVPIEDDNSSSIQAIFENMKLLFDDINIQLKLLTKIFKAINLTKFENQSLVQEVEDCKEKEKRNRFVNIDEALEASEEETFLLIFVLANVVEHFIKSTEDIKKFDLISTETIVGIIDVVCIIIRRYNRKLMKNTYEECETLKFGIAVLAAIILVAENNANITKSLEELGKILKKFVILSEKFSALSSLRDEAVGIIEIITNFLGIKLEGIIINESPSSERVIYDTKRSDLFEECLEDLKDELEAVKGHGLIIIAREIRNKNLQFLKKDRLQLLFSIVPNYVKDNESYVFLSAISVLSEIAYIQPDPYLFNLIDMFVNYSDKENIAFRGKLGEAISKVCKLLGYLAPQYFDQILNVLLKDFKNEDEIIKASSLNALADLICACKGTKYGSIIHELLTGINFLIKSKDSTPLVRRSALHLLRSIIQSTDTQLLLGTVIPLDILTKIYCELKVIYKYDEDDVVRLHAQLTIIDINEIIKSSIGEIKDNNLSGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8N4</accession>
    <name>A0A0N5C8N4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8N4"/>
    <dbReference type="STRING" id="174720.A0A0N5C8N4"/>
    <dbReference type="WBParaSite" id="SPAL_0001427600.1">
        <property type="protein sequence ID" value="SPAL_0001427600.1"/>
        <property type="gene ID" value="SPAL_0001427600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001427600.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12757" checksum="361BBB7687C59C88" modified="2015-12-09" version="1">MSTGISRNEIFLGNRNTNLDKQKERIESLRQTLCEVKEVTKNNIYKVTEREEKLKVLSDKIDNLKETTQQFSSNATKLRKKSSISLYSFLVIVVIMAIIIMVSTLFAIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8U7</accession>
    <name>A0A0N5C8U7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8U7"/>
    <dbReference type="STRING" id="174720.A0A0N5C8U7"/>
    <dbReference type="WBParaSite" id="SPAL_0001433300.1">
        <property type="protein sequence ID" value="SPAL_0001433300.1"/>
        <property type="gene ID" value="SPAL_0001433300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000003">
        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001433300.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="66223" checksum="87EEB9D2A9A68A0B" modified="2015-12-09" version="1">MDAFYNILFSRKLESLSTMTQMSQDEILQNTKTVSQGLDALRDEHESIRRNILSTLDNLAGEEKDLAEEKIRIIDQQLEQINLGLEEAQTMSALAQYYQNAEAEKQKLKAQVRRLCQENAWLRDELNGTQQQLQLSGQLNAQLEEEKKHLEFMLSIKKYDADQHENEQKESIMEPSVNTTSTLQELGFGPEEEDELVASTNNYPQPTPANAMAASANAGYEVPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGHEHPDVATMLNILALVYRDQNKYKESANLLNEALIIREKCLGENHPAVAATLNNLAVLYGKRGKYRDAEPLCKRALEIREKVLGEDHPDVAKQLNNLALLCQNQGKYDEVEKYYTRAVKIYESKLGPDDMNVAKTKNNLSSAYLKQGKYKEAENIYKQILTSAHEKAFGPVSEKNKPIWQIAEEREASKVANKDPETFPDYSGWHNAVKVDNLTVTTTLKNLGALYRRQGKYEAAETLEDVALRAKKQLMEATKQSKGYFGTKGISQSTLDEVSNDHNTMHQMNPALSASIMDDSSGPTSQRIMSTSTSSSNIKQKLLGMLGVQSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8X2</accession>
    <name>A0A0N5C8X2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8X2"/>
    <dbReference type="STRING" id="174720.A0A0N5C8X2"/>
    <dbReference type="WBParaSite" id="SPAL_0001435600.1">
        <property type="protein sequence ID" value="SPAL_0001435600.1"/>
        <property type="gene ID" value="SPAL_0001435600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF32">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="212"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001435600.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50398" checksum="4A82CEC016E5B5CF" modified="2015-12-09" version="1">MAVIWNEDVQKILASFHIDDFRLQKISDDIQKEFDLGLKYGSEKSSIAMLPSYVPALPDGSEVGEYVAIDLSGKNLRIMLLTLSGNKADPVAVSCNFMVSQSVMKGTGDQLFNFIVNCLQKFLREFNLESTNLPIGFVFSYPCELLSIRSARLLWWTKGFDIKDCLQKDVVQLLEEALELNLETQGRIKAVMNDTVGQLAAAAHKYGPECILGVVIGYGCNSSYLEDVKKIEKFDAKSANYDHDKMVIVTEWEEFGAKGELNDILTQFDRDIDNQSVHQGKQIIDKLTGALYLGELVRGVLSQLILDRLLFNGMPVEKLDTPESFPTKYISEILGEPEGVYKNCRRICEELEVSTHGTSDYAIIREVCHVVSARSAAIVAAAINALLRHLETKKIMIGVGGALIQFHPTYDKLLEKKLRDLVDPSVEWQLVPAEEGSARGAALIAAVTEKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Q6</accession>
    <name>A0A0N5C9Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AcidPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Q6"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0001463500.1">
        <property type="protein sequence ID" value="SPAL_0001463500.1"/>
        <property type="gene ID" value="SPAL_0001463500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="133"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001463500.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36980" checksum="2CC5F9E041B5AA2C" modified="2015-12-09" version="1">MVEEQVDDSNNYGTIRNTIIEIEVGRSNNTFRRMMITLKQPFFFNILIFLIILFVFIIFQFWIVPTKRGFFCNDETIRYPFKPDTISASVLIISSILPNILMVFWGETNNAFNKKNLRHYRGKKYIKIMFQIIGNFLWGLILLCCFLNIVKVSVGRFRPYYLDVCKPDVLQNITCNDYNYILNYTCTGKNIGLIREASLSFPSGHSAISFFGATFFFLYIQTRAHSLKKCYYLPSAFQFTAITLAVFTAVSRIFDYHHHPEDVAVGIIIGILFGYYFFNYNMKFKKEKIMDEDDNDVEPSTEDLTQNLYDNNEMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCF3</accession>
    <name>A0A0N5CCF3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCF3"/>
    <dbReference type="STRING" id="174720.A0A0N5CCF3"/>
    <dbReference type="WBParaSite" id="SPAL_0001556300.1">
        <property type="protein sequence ID" value="SPAL_0001556300.1"/>
        <property type="gene ID" value="SPAL_0001556300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="10">
        <location>
            <begin position="400"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="10">
        <location>
            <begin position="598"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="797"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001556300.1"/>
        </source>
    </evidence>
    <sequence length="1026" mass="118049" checksum="69ED0FFAD7CD2E44" modified="2015-12-09" version="1">MAEHMEFSKLLNELQRYGNSYKKYCANKNIIEEQCKKSDSAGNELYDTLTDNFEKFLEKSESLDASDKILEDYLSIINEESFHDVLLEMYNNLPKRFDSDIRERLRLIVEKNIISDSDDSDSSSYNTSDSNVDNEFSRPVSRNSSCRRSSRLQSRQNKYIKNRRDDKDYLEDPDKDFDYDDIDSSTCDVDNVSIQKVVLDPTVHDKLDSMIKMDLNAVIDIELNTKKIADKVHEITHCLGISRRIIGPIVAKLSIGGYSELITKKKCWSNLKERMQVSMRRLYAWIINKEAILFIHSLCPKKAQYYGNDKIVIPKPSYFWLNCKDVPMDEVERTLTPPALVYEEENCPTYGEFKPNVRVNKYIRAVESDPTISEIIQRTGKTYEFQNKNIILANIKHMSTKSFKFKGYLNTVEICKEIRKHLTETNCSQRSFAENILGMSQGSASDLLTKPKKWEGLTRRGREPYVKMRAYLDVHLELKDQLKSILEEEEREQLEKLKMLYKHKVDENKKKIDTTLLLKVLGNYCDEKSPPSSDSGFGTEVCDLNTSYSEENCNEKSILQKTEELFQNKRNFRVVAKASNSNQNLGNQPTDVTTVTSSFPLSFTESLNTMALAVEMKTLLDECKVTPAIFAEKYMKIKPQDFHRLLVAPRAWNLSSMSDRNAYEKINIFLRNKDFVKCLKEKGLGAFPLIQGYINNDHNQSQQQNNDKYIRLIRPLIPLEASSSLCNSKVIKVCIKKRQPQVLTNGAPIKKQKLTQNYSIVEDDSKIKKSSNVENVIRTPNSSLNGSRHSSRLVPFDKEIPTTSGQGINNSEISEGIKKDLDDNSESKNIVNTKSVGSLHDSPTIQVKEEYTEKVAETNGQSTPSDDSLTNHDAEIDTRVRDPKSFTILHEDNMKPIHKEELNVYNVATCHGKFIKYEDNLEFLIDTAELEILYLAWTYNPNPQSVMKEYLSQMTVLPIEAIESWYSKFNKLKGNYLRTADNSLTYRENLRKIVLTSTSRKKFLAVTDLVFKQLFSNKIAELINTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD33</accession>
    <name>A0A0N5CD33_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD33"/>
    <dbReference type="STRING" id="174720.A0A0N5CD33"/>
    <dbReference type="WBParaSite" id="SPAL_0001577900.1">
        <property type="protein sequence ID" value="SPAL_0001577900.1"/>
        <property type="gene ID" value="SPAL_0001577900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001577900.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60958" checksum="D2CCA390D4872638" modified="2015-12-09" version="1">MSVSKEIKQFIGDGWENINLKLDKIQPGTLVILTIAGTYVVIKFNRWCKKSEKPIHKRIYSYFFSLLRKLPVVQKEIEKQLSNTKKDLIHSIHKYDKEKKFIKEIPIKAMSTEEILTLANDYEKMSTFDVKGGKVSGTVYTDISDDHLKLLTSIFHNYAYSNPLHPDVFPGVRKMEAEVVRMVINLYNGTSECTGSMTSGGTESIILACFAYKNLAISKGIENPIIVCPSTAHAAFDKAADLFGIRIRHVPVNSNQKVNIKEYEKAISSETCMLVGSVPNFPSGTADDIVSIGKLGLKYNIPVHVDACLGGMLIPFMEEAGFPMPLFDFRVPGVTSISCDLHKYGYAPKGSSVVMYKKAEYLHKQYFSVTDWSGGIYATPTIAGSRCGSAIAVAWATLLFIGKEEYINRTRKIIDSCRKIAKKVTDLNNGIEVHGNPDVSVVAFKSESFNIYAVSDALNKNGWNLNCLQNPDAIHFCLTYNQASDEVVNSFVSDLKNAVDEVMADPEKGNKSKSAAIYGMAAQVPDKSLINDVTNLYLDTCFMIPEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CD47</accession>
    <name>A0A0N5CD47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CD47"/>
    <dbReference type="STRING" id="174720.A0A0N5CD47"/>
    <dbReference type="WBParaSite" id="SPAL_0001579300.1">
        <property type="protein sequence ID" value="SPAL_0001579300.1"/>
        <property type="gene ID" value="SPAL_0001579300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="604"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001579300.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="91428" checksum="DA5CFAB22C3F37CC" modified="2015-12-09" version="1">MTFRDIQNFSLIQNNLNCFGIPSKKSDFLLLTHNAKSLYYFYFSNPSMSKVLNLEGSFNSFCEEFLIFDIFYLKNDKLVLLIKSTNNRHLYIVSGDINIEDGIVYTDDNETVDTGIICDERGRKCCVTFDNIGPVIIDYPVIQGRNNSPIKLFHISEYFETKVNKLQIIVPEIRPENEVICSNPFISNNYIYFFIQMSTQILAIPITSDNYTYTENHFKAKILNTYSKKSKEMPSKNICARDILSFNDFLLVYCYQNLEANIEKPSLWKLDFNSLVWTKLEFSLSHHYPCHDVKLRSYDDRAFLVGVCNIKNCNENNHFFEFNLSELINDDKENSINGNLGYKNSITSWKSRSASNPNFTTLPSSDKFDKDDGLTQSTISLDSGSCSAEENILSHNDKSVTNQVFPLNWSKKMSLEGVTKVTEQIRQAKEMGYTEDLIFQALQENSLLEDVIIPYSSTSALVDKLIYLTNKQNNNTNDNIKTKLASLGPTYLTTSKSFSENTRPKRYERSGNRLTGRTSRYHTLGNIERSPSAHTSLLTSSSSLPTTLSRSNLSLSSQNLLKTAEDSITRLYDTCQKEKEHYLIACKENVKTLEDKLNLEVKHRIRLQTLCEEKEETIRNLRDSVLRYRNYESRLTKANKSIEEWIAKYQGSEMERINSEAEFNRRIDKLTKEKELLQRKIEVQASDRQKIKDLTSENAKLKEKINQLESRIELFSDKESYERQLNDLKAENYRLTQQINSMSLCLCCCTNKPDTIFLPCWHLLCCQNCSTSLYDCPICRTSLQGKVKVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDN4</accession>
    <name>A0A0N5CDN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDN4"/>
    <dbReference type="STRING" id="174720.A0A0N5CDN4"/>
    <dbReference type="WBParaSite" id="SPAL_0001597800.1">
        <property type="protein sequence ID" value="SPAL_0001597800.1"/>
        <property type="gene ID" value="SPAL_0001597800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001597800.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32622" checksum="8A600B9FA8733B60" modified="2015-12-09" version="1">MFKFVRYVPKKKLSSFFIYGTIFVSSLLIGYKIVYTNIDNLVMDMITRRDIKMIAEYIRNEALAGRRIGENPFKEYIGLPKIDWHDYKQMEEDMKREGNGEQGKAYVIPFGTPDDEKLQDQLYRVNGYNAYISDMISVNRSVKDIRHPKCKEMKYVSKLPTVTVIFPFFNEHKSVILRSIYSILNRSPPNTIVQIILVNDGSTKEELNEPFNEELKRLGLSNIVEMIKNKKREGLMRARQLGAYKAIGEILVFLDAHSEANYNWLPPLIEPIVFNYKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDP3</accession>
    <name>A0A0N5CDP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortilin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDP3"/>
    <dbReference type="WBParaSite" id="SPAL_0001598600.1">
        <property type="protein sequence ID" value="SPAL_0001598600.1"/>
        <property type="gene ID" value="SPAL_0001598600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001598600.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35406" checksum="76E1A972B00D29A9" modified="2015-12-09" version="1">MTDNDRRRLSIPLNIIKGSVNTSKHVTNQRYITDFRRVSEDVNIPHHVNNKIPDSVSEIEMDFGNNYLFTPNNVPLDNRVIKFGYASLLENVNCESIFEESEQVSNNNFEGSINYSVSFGRGHNMIDTSNSSINNNHLFLLRKDNFKLFQLHSKCLTLKETMNLWYMLPNEIQENIIVMIEKLDALSNNNYDYFWIEDCYANMIKIVSVSNLMEICTNKKKSVRWKNLSNGNIIVHRYSIPYISPKYNLIFSNTIKNNRKCCLLSIWLFMIFVISLAIILTIILDSKESISFSKRNHTNFMVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDZ0</accession>
    <name>A0A0N5CDZ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001607900.1">
        <property type="protein sequence ID" value="SPAL_0001607900.1"/>
        <property type="gene ID" value="SPAL_0001607900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="2">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001607900.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20079" checksum="AE8FCC18BDA5008F" modified="2015-12-09" version="1">FSQFEFFSHNDLKRINYLYCKDECEKTHKCDHGGYHEQSCFVCKCPYRLMNEKCTSMYPNLGNCSIERNLWASRSEKKLLVKNFAGVCHFSIKSKKGKKIRITVLELKLSRVNLCAHDIELEIKYSRDKGAVGLRLCDNYKNIKIPAQSSEIFVTFGDSKPNNKLSISYQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CED9</accession>
    <name>A0A0N5CED9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CED9"/>
    <dbReference type="WBParaSite" id="SPAL_0001622900.1">
        <property type="protein sequence ID" value="SPAL_0001622900.1"/>
        <property type="gene ID" value="SPAL_0001622900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001622900.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18970" checksum="4EC619C1BEBC7019" modified="2015-12-09" version="1">MPKLFNLSIHLQNSLSEVAVLINKCSFVQNLFVFVYLKHDEGFIEKDWENLLDASKNITTFTFSIYALCDCHNEDCFYYTSIPQFLLKNRSKLEKSNGEKLFKLEYMKILNYNHKIECNVCKSYFSYIDRKCFVCPENLVTLERNAQEIICLRIAQISKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGA2</accession>
    <name>A0A0N5CGA2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGA2"/>
    <dbReference type="WBParaSite" id="SPAL_0001688100.1">
        <property type="protein sequence ID" value="SPAL_0001688100.1"/>
        <property type="gene ID" value="SPAL_0001688100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001688100.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43781" checksum="CCE3336C7C1DB648" modified="2015-12-09" version="1">MVRHMRSNLFDNLRREHSSDSEASSLNYFRNKKNSFNFRYKRPYNSTNSWRNNHCNAHCGVNYIFSPSPIKRKKAKNGSINGEYSYHRTINDKFRIEFKKYSDNSNKPHIMKRLSNSMDPTHFNELKRRNGSYYRRRNRDNIPYVILPIDKNYIEVIPTKYKEVNPFIYKKILENTPGIKFTRKGIFKTPDYVEFILSLEKERSSSKKKFFNKNSLIKLQDLTPINNQSKENQVFEVITRKSITMDSRISRSISDISSANSNTSNNGVSSNCVVKREANLPKVTNKYSNNLRHGTRPSSPINNFKRSRFNSLEQKTRGLTVADCKYYKEGRCRFGLRCNFLHGTEPTVGYRRVQDFEKIRRSRSYSYNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGJ2</accession>
    <name>A0A0N5CGJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0001696800.1">
        <property type="protein sequence ID" value="SPAL_0001696800.1"/>
        <property type="gene ID" value="SPAL_0001696800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001696800.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="63500" checksum="E0AFD6C5FE63F2B6" modified="2015-12-09" version="1">MPSVYLGAPGANYNYQSGTNNNTNNKGNGYNGNYGGKGNNSTYLTPGVNQTPNGKSSYGGAGTGFGHGGSGNSSYGQNQFGGGGKANSAYYTPTMTNPTGGSGYVADKYSGGGQQSPKGQGSQSQFKGIGGGGESPGGGAGKAGSAYLTPAMAKTNGSSGYLNQKYTGGGSESPGGGGAKNPNTNLSPGAAASNGTSNNTNSKYSGGVNESPGGGGTKSLNSNLSPGIATNNVASSNTKNKYSGGGNESPGGGGTKSLNNPLSPVTAANNAASISTNNKQGGGAQYPSNVQVGQYPFAEQGNENPTGGNGGQSQIKKTGVGGVKDASGYLTPAMANAKDNSGYATNQKFVPRKNQTEEQGTKKHFKENGVGNEPIGSDGAKGDNVNLIQENQNGVSGNTTNRNADDDKNVSRRNGGRSQLKGIAGNPGAEEPESPGGDKTKGTIADPTQSSGNERSKLDKATSTKNDIKTNPAGLVNRNEFVSERSSKATDIKSNNKAIIEDVKSAQMAASMVTAITNSRTSSTTQDSSTLMNTAIHDAHSIETKTGIMIGRTKKPGQKSQEDLEDDDNKYVLLPGDGEDIAKHKANAANNNGDSTNKKKKKKKKKKKDNKVEVHIVYEEVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGU1</accession>
    <name>A0A0N5CGU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGU1"/>
    <dbReference type="WBParaSite" id="SPAL_0001706600.1">
        <property type="protein sequence ID" value="SPAL_0001706600.1"/>
        <property type="gene ID" value="SPAL_0001706600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001706600.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22186" checksum="021F0A5406C877E6" modified="2015-12-09" version="1">MDSNSDEICSEVQDDLSVLPDDALLLIFWELSLKDILHVNFVSKRFYGVVHKNYHRLRRREVHSISTKYNESCDNYPFHLEMTIRSVEDRDSHAIRHDDKKAKSIKSFDERTGFLKMFDIRNLDNFIVPVADNLDIFAILNRSFQAGTKIGEMVILELPENFSGGSEHSLRNFLRSRSFLSNIYVLLQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGU4</accession>
    <name>A0A0N5CGU4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGU4"/>
    <dbReference type="STRING" id="174720.A0A0N5CGU4"/>
    <dbReference type="WBParaSite" id="SPAL_0001706900.1">
        <property type="protein sequence ID" value="SPAL_0001706900.1"/>
        <property type="gene ID" value="SPAL_0001706900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056006">
        <property type="entry name" value="DUF7584"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056007">
        <property type="entry name" value="DUF7585"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24488">
        <property type="entry name" value="DUF7584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24490">
        <property type="entry name" value="DUF7585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895921" evidence="2">
        <location>
            <begin position="22"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7585" evidence="5">
        <location>
            <begin position="33"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7584" evidence="4">
        <location>
            <begin position="221"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="3">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001706900.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="53981" checksum="DAA74CC7F0CD9591" modified="2015-12-09" version="1">MFVKLYLLGAALALMPLPIQPQGPHDENLSLDVSENIDGPKFSTDVEVEKSSHIVLVKCSNDAYPHGNTGYKFTTSKDVTKYKNLASSTTSKYIWVPVLKKSSNSTRFSCGEVTIKPGDVMSHMIGWTYNVKWNNVREDKTRINSNNMDYPLPETHSKCHNETKNLLIVDKENDTAVIINPRDVKNPYANQEFYYFITPKQNDGRQIIEHCGRYRGYRNSPHFNLPDHSDNPTINEVKKININELNYEKEEKIKINLKLGDDIQFYRDEGISLSRMKYTIDGLIDIENSTQQINSSFTIKGFDLVKLVYNHLDATGYNEVSQVYYFGPASKNITIEKYYDYHDARSFNPNCPIYFMNVGYLDKVIYDGEEKSIDRSLDFISFERGYGCGCFCHRHLVCIYKTLDGTITISNKYDHKDIDVFHCNRLNNILSSEMKSDIFGISWIIFGASILFLLILIAVIIIIVVRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH11</accession>
    <name>A0A0N5CH11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH11"/>
    <dbReference type="WBParaSite" id="SPAL_0001713600.1">
        <property type="protein sequence ID" value="SPAL_0001713600.1"/>
        <property type="gene ID" value="SPAL_0001713600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001713600.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38308" checksum="A3A98F4E7ED3897D" modified="2015-12-09" version="1">MSSKFDDYYYYKYSITPFFSYDYDYDYDIIENKILSHTSFGMIQLSLSLLFIVLQSFILFVIYRKKLYYNNMPYRIIMHQGQLALFQLFGHFVTSISVILDLDGGTLFASIIGSLIRSCYISCVLFIFILTLNRLVIMYNISYFACARKTFYTFLIALCYLITIFAFGFFLLPYFRLKYHEDLFLWYSTDYNDTISLIWIIQSKSIVTILCISFAMHIVILVKIIVLRCITSKSIITLKELNFLIYAVLNFASCAFYELCIRGLYIRIHYIKYSSAILQLIYIFVSGSNTMYTVCFVRDVRQSILPMLLKKKHIKVTKVKVVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHC4</accession>
    <name>A0A0N5CHC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHC4"/>
    <dbReference type="WBParaSite" id="SPAL_0001724300.1">
        <property type="protein sequence ID" value="SPAL_0001724300.1"/>
        <property type="gene ID" value="SPAL_0001724300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001724300.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26316" checksum="E5FADBAE84648216" modified="2015-12-09" version="1">MFNGEGVVMSGTHFDVDNDPLPGTDVLEHARSGIQEPVIGDSPRMELKYLFYAMNGLMLFLILVVLAIIINSVFLVKYSPIKKRRNQVFQEYFKAKAQNSIKYNDYDKLLNDLEVLKKDIERNEKIKTKRNKERRVIKKNCNHKKPVIVMNEEKLAEVFHALAKMPSDLDGIVNGDGSKKRGVLMIGENETVCVMNRNDDGNKTARSIDFRSSRKTQKDSKIESLVKHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHQ9</accession>
    <name>A0A0N5CHQ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5CHQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001737300.1">
        <property type="protein sequence ID" value="SPAL_0001737300.1"/>
        <property type="gene ID" value="SPAL_0001737300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000458">
        <property type="entry name" value="E2F-like (Mammalian transcription factor)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="9">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001737300.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52660" checksum="AA824FDC48FAF680" modified="2015-12-09" version="1">MDIPPRTMTTTVGPIKRQASDSPNRVNKYLAVTQPSPRKVDRNILKTIIPKVEYVGSESGEIKRAIPQARYIEEHVSLKNNDKNFHGPHMEPQKIKVAPPCGNARVDNSLLRLTQKFLELRNSRSGNDVLNLNEAAEQLGVQKRRLYDITNVLEGIDMIEKTGKNSIRWKNKSDNDAYEMEENKLKGQIKKLDAFEREMDETIESLQSYLKILLHDPSSLRYLYTRAQDLQKSSSISDSTAIIFKAPRETHSTLLVGDPVVYGKFELTVRNDDGYAIDALMLPNNTNTVKHDIMSDDRICTKNKSVKIESQESTLISSGKVSASSPYTLINNSPFPTPFEGHISNPHQISSSQDFNQFLSPSNSTFAQDDSLSGLDTDTLLTSNSFQPMDFAQYLSPLKESNFQNDFGDELFMHQPYSNHNLANENGIINKQNNFFVHIDPLEEQERYPENAGDAGTLFNVFSNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIE8</accession>
    <name>A0A0N5CIE8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Odorant receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIE8"/>
    <dbReference type="WBParaSite" id="SPAL_0001760300.1">
        <property type="protein sequence ID" value="SPAL_0001760300.1"/>
        <property type="gene ID" value="SPAL_0001760300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001760300.1"/>
        </source>
    </evidence>
    <sequence length="30" mass="3606" checksum="65A435127F4DD703" modified="2015-12-09" version="1">SIYFARIPLSLKTHIFILKFLEQTFYGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIY5</accession>
    <name>A0A0N5CIY5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIY5"/>
    <dbReference type="STRING" id="174720.A0A0N5CIY5"/>
    <dbReference type="WBParaSite" id="SPAL_0001779100.1">
        <property type="protein sequence ID" value="SPAL_0001779100.1"/>
        <property type="gene ID" value="SPAL_0001779100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001779100.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7026" checksum="F17F3C38EEFF11BC" modified="2015-12-09" version="1">MVCRKKHDYQAMVKSCPCRDAIARLAKSGMKNSAISSKLGVPLRTVQKIVKQWREEGHVQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B279</accession>
    <name>A0A0N5B279_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein TSSC4</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B279"/>
    <dbReference type="WBParaSite" id="SPAL_0000018100.1">
        <property type="protein sequence ID" value="SPAL_0000018100.1"/>
        <property type="gene ID" value="SPAL_0000018100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000018100.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17833" checksum="DF870CDD93909BD4" modified="2015-12-09" version="1">MDEELIIKFLEQIRKDKFDVKEIAKIDDIVPAKKVFFNDDDKTDSLDSDDEFLEAFENFAEIVCPKVDRGELKCDHMNKPVKEKKSKIPHNKKLHCEKKRESLNYDYHYKPERRYTYEEERITITDSLKTMRELRIRDEELKMQCGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W2</accession>
    <name>A0A0N5B2W2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2W2"/>
    <dbReference type="WBParaSite" id="SPAL_0000041400.1">
        <property type="protein sequence ID" value="SPAL_0000041400.1"/>
        <property type="gene ID" value="SPAL_0000041400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893653" evidence="1">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000041400.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24247" checksum="2CA527D2401D74A6" modified="2015-12-09" version="1">MIITDKAGPVAAALLLLLARGATPLPYNARGVAGAGALVGGNFNHDGNSFHGSFGGIAGAAGGVHFQGGQSNERPVPSHVMPPMNGDPVEMEGFYHVPASNELPKANDVEEQKAQSPELYPVPAHDMPRVAEETKVPSNEMYYGYSTEAPTTEMYYTSTEAPSTEVHYDSTTEAPTTRVYYASSESPSTEGYFAPSESVMGYSTEEAKAPATEVNFAAPEMSYVPQDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B398</accession>
    <name>A0A0N5B398_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B398"/>
    <dbReference type="STRING" id="174720.A0A0N5B398"/>
    <dbReference type="WBParaSite" id="SPAL_0000055000.1">
        <property type="protein sequence ID" value="SPAL_0000055000.1"/>
        <property type="gene ID" value="SPAL_0000055000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF247">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-6 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="187"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000055000.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42502" checksum="F74664CE64E2C6AC" modified="2015-12-09" version="1">MGTSHSLLLSRNSADKRNGLGSAKNNAKNNDDILPKNLDKDRNFKILLLGGSECGKTTIFKQMRVLHLNGFSDADKDQYKEMIITNTIQSLGQLIDACKKYRIMPEALMEKHIEIFCIFRNEFLNKHCTSVPPDIARTMKKIWNTSQIQNVYQKRWNFPLLDNAKYFLQSIDRIFANDYVPTTDDILHCRHPTTEINELIFRYKKANFRMVDVGGQRSERRKWIHCFDNVNIVLFVVALNEFNQKDPEDDKYNRLSQNRNIFKTVVQSNFFRKATTVLFFNKYDIFQEQIKYTSLKDSWKDYNGGSTLDECTRYIKTSFQSCVPDSSKYYSHLTTATDTNNIDYVFANSVANTVNQNLKSIGLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3N2</accession>
    <name>A0A0N5B3N2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3N2"/>
    <dbReference type="WBParaSite" id="SPAL_0000068500.1">
        <property type="protein sequence ID" value="SPAL_0000068500.1"/>
        <property type="gene ID" value="SPAL_0000068500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000068500.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17283" checksum="3F5184366E21A527" modified="2015-12-09" version="1">MKTIAIFYFVAVLFLHFNPTIQWAKFYYITRDWIRSPFNNSVTACQYAICKAVLNAKKIKGLDEKKACNEISDAYGGVGEYKKSRFQYLEVYSIVKTQNGKDTLYGEDGLFQYIGDCVCANKQCTNFKALCIYTYWFGFKYIWNNQMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3S7</accession>
    <name>A0A0N5B3S7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3S7"/>
    <dbReference type="STRING" id="174720.A0A0N5B3S7"/>
    <dbReference type="WBParaSite" id="SPAL_0000073000.1">
        <property type="protein sequence ID" value="SPAL_0000073000.1"/>
        <property type="gene ID" value="SPAL_0000073000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003101">
        <property type="entry name" value="KIX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02172">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50952">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIX" evidence="3">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000073000.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="47963" checksum="0E88F21D0DDBF300" modified="2015-12-09" version="1">MHINCYQEQSLMENCYQKNDSTIDDESNHLNNFKHQFEEKNHKQNYYYDLAKKMVKIYDQLYKNYFESLEEDNENKEAITYNLKQNITLESREEVLNSIIKVIYPFQCENMENNVSIDLRKYLLKIEKEVFDSAQNKSDYYKKLHQRIFKIQNELRNFSLYYHDFERDIKKNKEEKYKYLKYKSIEAIRLPDIKKKRSTTSNDPKIRKKNTLSDVISSKEQHIQKIDQIKLEVHENNDNYINKQSKKEERFDTDESHKVSSETLLNHPVVKDNIGNRSQQNANEVVNNQNNIEFNINKPAHQHFMKIKNIIFSSIFHTSNHYSVKNKNIKQKNKSKVVDKKSNEKESDVEQKAQKIEDNVNSNLTKSNHKNVINVIMEKTYIEMSTEFLNLIYYILEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4S9</accession>
    <name>A0A0N5B4S9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4S9"/>
    <dbReference type="STRING" id="174720.A0A0N5B4S9"/>
    <dbReference type="WBParaSite" id="SPAL_0000107800.1">
        <property type="protein sequence ID" value="SPAL_0000107800.1"/>
        <property type="gene ID" value="SPAL_0000107800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000107800.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="41872" checksum="BB1E2EAE938620CB" modified="2015-12-09" version="1">METFKKESLEESLNSKKEDFKDYEVVDIKDAHRFIVDCMKNVGTNEGHASLLADVLLKGDNRGHYSHGLNRLEMYMKDVQSKVCKGTGNPILLNNFGATGWVDGNNLLGPVVGDYCIKLAIEKAKNFGVGWVCAKGSNHYGIAGYYALRCMKEGLIGISMTNTSPLMLPTRSAKPALGTNPIAVAANGIGEDNFVLDMATTTVAIGKVELAKRKNIEVPNSWGADKTGNVSIDPSEILDGGSLLPLGGTEECGGYKGSGLGSMVELFCGILSGGHWGPNVRRWMTTSAEADLGQCFIAVNPNCFAPNFDYRVQDFIDTIRTLPKANEKGPAIQVAGDQERFHEKFVDKLGGIPYHPNQIQNMFNISKKYNVKPMKLIGKVSDIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B684</accession>
    <name>A0A0N5B684_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B684"/>
    <dbReference type="WBParaSite" id="SPAL_0000157300.1">
        <property type="protein sequence ID" value="SPAL_0000157300.1"/>
        <property type="gene ID" value="SPAL_0000157300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000157300.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18949" checksum="74BF0A3FBF9D6ADD" modified="2015-12-09" version="1">MSENRFYCHFDLFFQFTMFFSFFIIAFSTNLIGAEVIGQSTVNHVLQSQNFQRNQDFTSPYNMKTRPFDSYKTFKDNLKNKMSKIYTKNQDHSFRQPIKFQQSKQSRNCFFSPIQCQLNIKKLNNLKDPSYSLFNKRPNSIFKKNYGLDKTMRFIVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7L4</accession>
    <name>A0A0N5B7L4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7L4"/>
    <dbReference type="STRING" id="174720.A0A0N5B7L4"/>
    <dbReference type="WBParaSite" id="SPAL_0000203900.1">
        <property type="protein sequence ID" value="SPAL_0000203900.1"/>
        <property type="gene ID" value="SPAL_0000203900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000203900.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="63415" checksum="202A46242922BD60" modified="2015-12-09" version="1">MDTKSSPNPPNKFDKESEIPAEVVKFIVYMKKLYDNRSVNELKQVYDQGFIDISEKYYLEKPWPNPSAIEKVITNPKEHFMIIYKEIYYRDIYYKSIKKALPLDIQCESFTNLSSFFSLLLNSDIENEHPVTFLLPANWIWDIIESFINQYVSFCHYKANPSLRTIEENQQLEEIEKNKEYWNIYTVLNILYSLISKAQINDQLIAIKNGNNPDDIANEFGRNDLYFKVGYFAMIGLLRLQVHLGDYNEALQCVENFSLEPKGLFTTVPNCYITVYYYIAFGHMMTRNYIEAIKLFEICSLYIQKITNVYILQNLSYSKKNKELEIFNIFQDKVLILLAICLTITPQKIEESIKTLLHDKYDETYNRMISGDITEYEKNFMIGAPKFISPNCVVYEGNSISRQSLQRQCSAFINCMRGQVWTPVVRSYLKLYNTLTINKLSHLMDLSTNNVMSKILHFKKATSITGRNEVLKRNDDDYEDTTLDLDFYIDDEVITIADTHITRNVSDYFLKNSLKFKALSVKAKAINLNGRSVTSRRNPDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B835</accession>
    <name>A0A0N5B835_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B835"/>
    <dbReference type="WBParaSite" id="SPAL_0000220800.1">
        <property type="protein sequence ID" value="SPAL_0000220800.1"/>
        <property type="gene ID" value="SPAL_0000220800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000220800.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24584" checksum="34B4A9D4A068B8AD" modified="2015-12-09" version="1">MKIYYIDNNILLFLYLLFFINNIVISITNFNGISSTNKNYSIEDVNFYKVDKNKAFKDIKNNSTSIILSVKNKKLPTTKPPIKKGTLFSEWDSKTSRVVCQFFVFGTLFGVVCSISACTCLLQPNNRRGIPELSIDPPPPMIEDDGKPIRIQFGDDGLCYARTLSDNEVPPLPDYYSALSLPNDIISSLHRQMITLGLIDDEGTKKSIINDQKNSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B836</accession>
    <name>A0A0N5B836_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MRP-S28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B836"/>
    <dbReference type="STRING" id="174720.A0A0N5B836"/>
    <dbReference type="WBParaSite" id="SPAL_0000220900.1">
        <property type="protein sequence ID" value="SPAL_0000220900.1"/>
        <property type="gene ID" value="SPAL_0000220900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="197"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000220900.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="34194" checksum="E9BF18B8091BC8A4" modified="2015-12-09" version="1">MLRVNSFLNSPRSLFLFSNSLRSSAYLKENAAEMGGKNKEEFRPCFVMPNRKLNAQLRLERMTGRGEVFKKVRYDIRDRSSRRPPRTQEMDVNQDWSSVWPAAQSFRAHTVPLPIRMGTRPDLDKRPPFKKVGNLELVKIPNFLHLTPKAVEKHCDAIKKFCTPFPEELKQDKSLSSKVFPLTVEYSDFVHQGPSLRDPRARKVVQKVSLKSLNLSEEAKEKMMRLVGNRYDMKTDLLTLEIDRCYTRKQNRDYGAYLLTVLLSEAQKVEPWEKLKSSGDEMKMKFEDFQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8A4</accession>
    <name>A0A0N5B8A4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8A4"/>
    <dbReference type="WBParaSite" id="SPAL_0000227700.1">
        <property type="protein sequence ID" value="SPAL_0000227700.1"/>
        <property type="gene ID" value="SPAL_0000227700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000227700.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20357" checksum="687ECDA6688219ED" modified="2015-12-09" version="1">MANINNQNVHVITNNEEETNEDTNLPRDNNEIISNTTNTTFPQYNNLDVSIGSSELEGGLCDMCETPIEIPSLQSVPLHSKPSKQRNFSIRNYGIPRELINLIAVPQRLFSGGKEVFQEKNNSLIIDKSYEVTEKKNSVRNKYEAICCDIVNRIENEISNLEKKLTSQLNIKEQKDSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8N3</accession>
    <name>A0A0N5B8N3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8N3"/>
    <dbReference type="WBParaSite" id="SPAL_0000240600.1">
        <property type="protein sequence ID" value="SPAL_0000240600.1"/>
        <property type="gene ID" value="SPAL_0000240600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894080" evidence="2">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000240600.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12856" checksum="208DBDBBE3CC603F" modified="2015-12-09" version="1">MINNKLFILLLCFSILKIGLLYNFCALTPVNKAEERKWCGCRNDIPPLGPCVGGECPPGYMCVCDYCCEGCYDDCYDCALYAQYCDNVNYCDLRQKCKSTCNQCKDADYEYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8R7</accession>
    <name>A0A0N5B8R7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8R7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8R7"/>
    <dbReference type="WBParaSite" id="SPAL_0000244000.1">
        <property type="protein sequence ID" value="SPAL_0000244000.1"/>
        <property type="gene ID" value="SPAL_0000244000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244000.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="60190" checksum="7C0BA9CAF193E12A" modified="2015-12-09" version="1">MDEFIGNEGENSSISKNNNNANLYNQEFINNNIEIGYNYSINSNPPHECAFNPPVYVEERFWLVTVAGTTLAIICIIENAFLFTMLARKRKYRNSYVLYLLLLALFDILIGMAYIPLMSLSLYLDYIQSVFLLRAWYAYMIPMITVSHIAMTSTTFLIVAASWERYCITASNTKMVRFLSKYRKNIAACSVILGMLTKISLAFEFDIKFIPRCINTMAEYELNSSSLALSYYYALFWRLIFRNIFTILAPFFFLLIINARVVYILHQYPTTITNTFPIDTSFMTTVMGKQTNNPKLSYEYQRKIRVRAATKTLLFVSLSYILSNFLNVILTLWEYIDIELLQLEYLSFYTVTVDLISIFTVLAGVLRLPIYVICMPEMRVEFVNYLHKMFHPKEYDRMLMVKKKPGFLKRIIHSQYKGSNIFIGMGEMWVLRPMDKKDHSNVMSDEDSLTTSPIFVDGNEYIEDGFFELSKNNSPTSINIDSSNLFDCKSIKDNMKDESYHSISSNNKDSFNSNEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S6</accession>
    <name>A0A0N5B8S6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4383 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S6"/>
    <dbReference type="WBParaSite" id="SPAL_0000244900.1">
        <property type="protein sequence ID" value="SPAL_0000244900.1"/>
        <property type="gene ID" value="SPAL_0000244900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244900.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17744" checksum="101DCFE4C086ABD5" modified="2015-12-09" version="1">MLQPKYFFTPVLICIFLHLLVIIGTEQHTFSLFSGVNHKVIDAINIAIAIVDIILITLYIANFKFLRPHTKIIYFLILICGVIITLYSCTCFITIIFIKKIKLDAFTLICFTLQCVMLITHIGLLFKNSYSELESNDSKKSFMESLQNEKSNLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B915</accession>
    <name>A0A0N5B915_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B915"/>
    <dbReference type="WBParaSite" id="SPAL_0000253700.1">
        <property type="protein sequence ID" value="SPAL_0000253700.1"/>
        <property type="gene ID" value="SPAL_0000253700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000253700.1"/>
        </source>
    </evidence>
    <sequence length="19" mass="2071" checksum="6CF487CAF79D5E0E" modified="2015-12-09" version="1">IVLILKCEKTAGLDNNVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B959</accession>
    <name>A0A0N5B959_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B959"/>
    <dbReference type="STRING" id="174720.A0A0N5B959"/>
    <dbReference type="WBParaSite" id="SPAL_0000257500.1">
        <property type="protein sequence ID" value="SPAL_0000257500.1"/>
        <property type="gene ID" value="SPAL_0000257500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000257500.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9640" checksum="07C70902BA4AFA98" modified="2015-12-09" version="1">MFNKDTILIGHSLNCDLEALKLIHKNVVDTSITFPHRNPQFKNPLRKLAKLYINMDIQDAHTGHDSAEDAIAAMRLLIAKYQGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9D8</accession>
    <name>A0A0N5B9D8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9D8"/>
    <dbReference type="WBParaSite" id="SPAL_0000265400.1">
        <property type="protein sequence ID" value="SPAL_0000265400.1"/>
        <property type="gene ID" value="SPAL_0000265400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000265400.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21046" checksum="BEEDA58EB8BF5C0C" modified="2015-12-09" version="1">MNQKKFDKNDSFYYAPAAFELLHYKDAAIIGAILGISALSGAGLMFYFLHNTYHITGITTTILCFVTIISFIITTILMVFGIIKEKPNLMWPQMTILQLENVLLFILGSFSIISMACGTATTNFLFGFIVNVPEMETHLGPIWPFNIAAAAFVGCLICVWFNVLLRGAYDYLLDKQFFEGIEKIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBA6</accession>
    <name>A0A0N5BBA6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBA6"/>
    <dbReference type="STRING" id="174720.A0A0N5BBA6"/>
    <dbReference type="WBParaSite" id="SPAL_0000331700.1">
        <property type="protein sequence ID" value="SPAL_0000331700.1"/>
        <property type="gene ID" value="SPAL_0000331700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007256266" description="acid phosphatase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000331700.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14836" checksum="942019312311B07F" modified="2016-05-11" version="2">MKFLTSLFVTAFLIAGFFPLTYGQGNSQLIFIQSIWRHGDRSPTSSYPGDLYNESAWPQGFGQLSTLGMQEHILLGKKIKNRYYDQLNFIKKTYHNYDIYVRSTDVNRTIISAISNFIGFYYNSSTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBL8</accession>
    <name>A0A0N5BBL8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBL8"/>
    <dbReference type="STRING" id="174720.A0A0N5BBL8"/>
    <dbReference type="WBParaSite" id="SPAL_0000342400.1">
        <property type="protein sequence ID" value="SPAL_0000342400.1"/>
        <property type="gene ID" value="SPAL_0000342400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="83"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="328"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000342400.1"/>
        </source>
    </evidence>
    <sequence length="595" mass="69000" checksum="E0F4C434948BAF12" modified="2015-12-09" version="1">MSDSDEIVIIETSSKRKNVRKKKKCDREGLSDTMDETAMNIVDSLLISKDFLSLNPGRKATHILKHIFNYSRFRKPHQRDVVVDAIKRNTDIYISFPTGAGKSLCYQLPALSKQGVTIVFSPLLALIQDQISSLLKKNIRCCSWDSTLSSSDRSTISKDLFSNSPKYHVVYTTPESSKNEFFRNMMRSLYSKNLLNYFIVDEAHCVSQWGHDFRPAYLLVAELRDICPSVPWMALTATANALVEEDILKQLKFPKKFKTYRTSPYRSNLYYDVVIAEYLLKKEEDGNKKENLKNSENEAVEKSISTEDYRIEREKKCTLAIQKDVVKYINNLISAFKKRHGSKFKGFSGIVYCRSRAKCEEMSNFFIQNGISSYHYHAGLEKKEKKEVQDKWMSNELTVICATIAFGMGIDKSDVRFVIHTSTPDDLAAYYQESGRAGRDGERSYCRIYHSSYIKSKSEFFKGSKLEKITNCEKDTEDEKKRKCTNLNYTFEKMIDYCEKQKCRHQMLCEYFGDTEINCCEANCDFCRDKEKVKRQMESFHIEIKRNIALSEQSFVRKRVSTSEIKPHDNDLLNQPKRALFEKASEMNINNKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCC1</accession>
    <name>A0A0N5BCC1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCC1"/>
    <dbReference type="STRING" id="174720.A0A0N5BCC1"/>
    <dbReference type="WBParaSite" id="SPAL_0000367000.1">
        <property type="protein sequence ID" value="SPAL_0000367000.1"/>
        <property type="gene ID" value="SPAL_0000367000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000367000.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36465" checksum="8423C58E340034BF" modified="2015-12-09" version="1">MPFRCGICSEAYTSNGSDHALCSTKCGHLFGKRCLEKWINENSVDGECKCPICSQFVREYHPIHDVPNQLLEVTSDDGKNKCRSEDDVMRQYVLGTLKETHFFMKQSNKGRQELDNIFINFFDAYNGYILIIESPSITKSNTISFLKIYEGDTICYIKQFKSACITAVAINKCCEDSLEFCLGFKNGVILNTVISLSNRVHRTPHESIFFNEKKEINSICYLGYNNIVYSVGDSRVFNIFNIHVDCIHLKKNWFENATVKLKTVTNLKVVNDSTLFGLMNDKIYVFGKNTVPYEIYSEKDLLLTSFEYDSLLKNDVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCJ5</accession>
    <name>A0A0N5BCJ5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurexin-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCJ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BCJ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000374200.1">
        <property type="protein sequence ID" value="SPAL_0000374200.1"/>
        <property type="gene ID" value="SPAL_0000374200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894290" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="134"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="724"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="886"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000374200.1"/>
        </source>
    </evidence>
    <sequence length="1195" mass="136024" checksum="E1BADB6BA75A5564" modified="2015-12-09" version="1">MKSLYILLQQTFFILFLHILTIKSSSPECTDKQYSELNKIFENVQVLQKVAIIAPLGTYYLYTSLTENEDDLTPLLQQNGQKIVIHSSLTANNIEWHSMNVLVKRIKIVPIFEGNMVIKYHTPQLLINSCNYDTKIIYVDDQSYTVDSYNAGLVSMYENELIVNFKTFENGIFFFSVADQGDMLIAQIVNGHIEVTFDFGSLSKTTISGGIALNDGQWHELKWNHQFDSVKLLIDGILLNETTPAGLYRKLDFNYEIEIAGRPTDQYSDDIQSAFHGCLGRVYLNNIDLLSYAPKDKYTNCYMPKPQILTILNEGSSIFVPYSFMPFNFEFRIIKQNSNLLQILNANKDTLLSLSIEKNNSLFLRAEKQGIRQEYFSSTSISDGSWHSLSLKMRGGRFNVELNGLIVLWLEGSFVRNLGLSMTAFNISSVGCFRSASVDLKNALIFGDVIKNKCTFISRCHPNPCENNGECEQSQLDTFKCSCSNGYSGRYCHTSMLPYSCEDYIQRIQLQNKKSKGIFSGFKSRIKYETNITIDIDGSGPLVPFQVQCIYSNKTHPEMSDSIDTILYHDMPYGMYVTGSTEPGSVRRTLGYGITEDTLEKFIESFGFCKQYMRYQCRGGSKLMTYGNERRPSSWYATRNGQQGLQWANAPPYSRVCECTVNGTCNYNRMCNCDTGRDGVDDGYNTHSQLLPIIQLFIGGTHRTSSVNVTIGPLICTQKNTFDVVTFNDRNQRMVGIQQFNGHIFDLYIQVRFSHPLMTIFTWESKNSERWFQLFVREGYLVAQIVNGGRSQEIQSGLKINDNKWHTVYWEADTLSMKLVVDKEESVATMYNILPWTYNYIIGSRTERGFSGYAGQLRNFYLCGKEINLGLLARKHHNTKGIKAGYEGYCKAHYCKNGGTCIEMYDNYKCNCTLSPFDGDKCDQERSIFVPLKSELSIPWQHPTQMSNCFRMAVQTSSVNVSLIKAKALFAESVFNLSITEQGYLNISMYDGVFFHHQIIDNAVNMSDQTINDIMFCATKKTFELKVGNRISTQLNGNFSFFTNLNVWQFIDSNFSGCILRLQVGNSFPLKDPKSSRLTYSQNVKFDVCPHEKLLYKKDEIIDNSKKSDISVSIVTDNHRKLLILTPIIGITIGLVLCILLCCIICYVRSQPDGVYKTNETISAYCTGSPSKSAEYLMPGNVQHQFQPQNKEYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCQ3</accession>
    <name>A0A0N5BCQ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCQ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000379800.1">
        <property type="protein sequence ID" value="SPAL_0000379800.1"/>
        <property type="gene ID" value="SPAL_0000379800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000379800.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34120" checksum="2C5A1F35C9589BC8" modified="2015-12-09" version="1">MYEENTRSLRRYDINTLQPIPRVKLIPRAQLTREVYGLPPSRPSSKIGQIVEYHEDEVPNKNSYESPVPIEETKLGKMISVENAINGKRKIQEGNIGSGRFFFLFQKYPALVAIIVSLLLNYGQRYNSDVKYLVEERVQIIMSLANGILVAVGSLHGIQNHNYSFIRAKFLSIIKIPHLLLTITAAAIQLVYSVLSYIKLKNNQDNNTWLNTYSQCDIKSLTTPTTSYSIPCYNVHDRIVCSCILMGCAISIIILGLFSIASLLTAYINHKMDVDKLKERQARHSRVISAYTNQTAFESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCR6</accession>
    <name>A0A0N5BCR6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GtrA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCR6"/>
    <dbReference type="STRING" id="174720.A0A0N5BCR6"/>
    <dbReference type="WBParaSite" id="SPAL_0000381100.1">
        <property type="protein sequence ID" value="SPAL_0000381100.1"/>
        <property type="gene ID" value="SPAL_0000381100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640:SF1">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000381100.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18308" checksum="9BF8C34BE0C8E2B4" modified="2015-12-09" version="1">MRAQSSLTRWLSRPINITNVLSYYIPLTGVAAHGLFTANIFSPGLLRNICNEWDVFASKSLMATSLIGSGFFVFFRPHLYQTSKWHRVEYSVFSSVIYNFGTILLAIFVKPFIPKKLSTSFKTIIAFGISTFLASRTLKYLNHIDKRTNVKDDEKFTHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCV0</accession>
    <name>A0A0N5BCV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCV0"/>
    <dbReference type="STRING" id="174720.A0A0N5BCV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000384500.1">
        <property type="protein sequence ID" value="SPAL_0000384500.1"/>
        <property type="gene ID" value="SPAL_0000384500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000384500.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34848" checksum="78A24BF37FB4FB17" modified="2015-12-09" version="1">MGKGIILIGIFASISFVTIHFYIEMGNPLLIYTACAFNIILSCFFFIYFVVTSETMAYNYNQWVLRNEWLPGFIRESSIKNIESNSRKMILSSEGETPVIFPETFSNNMSPAHFSFSPSCISTYTYSGDKSLLCSNYKSQITSNISYQQNPSPFGLHNNDSKIISGGTMYDYPSVSFDKQNFVGTFSTANTLIHNGKNQIKYNYIGGNNDHHNGNSFNYPFESISPCLRTTPPKFPPPPPPQNVNGSATLQYKLNQGPITLSEDSAYSDSGSSTFIPPIISSGVPLVANYTSGSMVLRMDLNKKPPVFLNGNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE93</accession>
    <name>A0A0N5BE93_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE93"/>
    <dbReference type="STRING" id="174720.A0A0N5BE93"/>
    <dbReference type="WBParaSite" id="SPAL_0000431600.1">
        <property type="protein sequence ID" value="SPAL_0000431600.1"/>
        <property type="gene ID" value="SPAL_0000431600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000431600.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="30202" checksum="62CABF66E8E07A36" modified="2015-12-09" version="1">MEQDNKKLIREAENLRSIAFIGVAVSTVAVLMSIFSVPMLYNYMQQVQTVMQNEVDFCRSRSGNIWREVTRTQILSKVSGGRFERQAGYGTSEGVEGSFGARPTGGCCGCGVSPQGPPGLPGQDGRDGQDGAPGKPGRNGPDGPPATPAPAFDFCFDCPQGPQGAPGRPGPKGPRGNAGTPGRPGLPGKRGLDGRPGQPGRAGQPGRPGKAGARGAPGVVTTVEGPVGQPGPAGRPGPKGPDGRPGAPGQPGRPGPQGQPGNPGSAGLPGTPGSQGQPGPAGPKGSPGACNHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEW3</accession>
    <name>A0A0N5BEW3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEW3"/>
    <dbReference type="STRING" id="174720.A0A0N5BEW3"/>
    <dbReference type="WBParaSite" id="SPAL_0000453200.1">
        <property type="protein sequence ID" value="SPAL_0000453200.1"/>
        <property type="gene ID" value="SPAL_0000453200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000453200.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16388" checksum="C5BFC5D707F41842" modified="2015-12-09" version="1">MAHSLRKTRKLRGHVSHGHGRVGKHRKHPGGRGNAGGAHHHRINFDKYHPGYFGKVGMRVFHLNRNKLYKPSINLDKLWTLVPEDTRTKLVGVKDKAPVVDVTAHGYHKVLGKGFIPTQPMIVKAKFFSHTAEEKIKKAGGACILVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFN9</accession>
    <name>A0A0N5BFN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax inhibitor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000480500.1">
        <property type="protein sequence ID" value="SPAL_0000480500.1"/>
        <property type="gene ID" value="SPAL_0000480500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF47">
        <property type="entry name" value="TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000480500.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28160" checksum="1FA632CEB25A554A" modified="2015-12-09" version="1">MTSPQEFLYRNKDEKNSKYPLLSRVTFLRKTICHTLMFLAFTAITIFFITKNNELEILFNQQHEMFSIISLTIFFTIYVAIIKSEKIRFTRGINYIAGFLLAASLGFLIAVESSWYTLEINVNSMFISIIVSIIISAIACKSEKDFTIYMKSLIILTIIFAIVSILSFIFSKVMDTSNPRHLCSLGGFLLSCAYIVVDTQSISTKDRCNQLATNEYVLGGVQMLVDFSYLFYYCMGVLGTEVSFETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG62</accession>
    <name>A0A0N5BG62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG62"/>
    <dbReference type="WBParaSite" id="SPAL_0000497000.1">
        <property type="protein sequence ID" value="SPAL_0000497000.1"/>
        <property type="gene ID" value="SPAL_0000497000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000497000.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41340" checksum="8F36DA718FA60042" modified="2015-12-09" version="1">MSLNELKIIVTGFPQTWNDWDIFHTFFKFGHIRNIRLHNKMAFVEMMTKEGYDNLLNYVEKEKIEVDGCTLVVKANQSKQIIDDPFLPHYEQHEDFYDTFEILDEKVYVNEFDGARNSLNFSFWVPLPFKDGKKFEKKLEIEFKKTKKSGKLAVNSFVVVKRCEEYMRGQIIKRLNHGAYVIFFVDRGFKTAAKEEFVRPLLDEDILNVRFKAALCTLANVTNTKTSFYNEFNNILCQNPSLKGYKMSLVGFEGFNSVVNINVIGKDGKSYDLAKALAERGVCDLIKAENFDEEENKENIGAGGKTLNSSPIHRYTSNEMRNIDKKEADLINKIKELRIQGNCLETVYNAKNQMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGQ1</accession>
    <name>A0A0N5BGQ1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGQ1"/>
    <dbReference type="WBParaSite" id="SPAL_0000515100.1">
        <property type="protein sequence ID" value="SPAL_0000515100.1"/>
        <property type="gene ID" value="SPAL_0000515100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000515100.1"/>
        </source>
    </evidence>
    <sequence length="28" mass="3317" checksum="3D3B50D60F10270A" modified="2015-12-09" version="1">MFYVCMKLLFFILSAFFHSLCIKINISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHH9</accession>
    <name>A0A0N5BHH9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein YIPF3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHH9"/>
    <dbReference type="WBParaSite" id="SPAL_0000542000.1">
        <property type="protein sequence ID" value="SPAL_0000542000.1"/>
        <property type="gene ID" value="SPAL_0000542000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008574">
        <property type="entry name" value="Nematodes_ZYG-11_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31176">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31176:SF1">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05884">
        <property type="entry name" value="ZYG-11_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000542000.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32537" checksum="1E13B2D111ABC7DC" modified="2015-12-09" version="1">MTSPHYVAQLAQKYQDEFQRNAIETGDTITITAREAVSTVQQKVDSIAPTAIGFKDYFISVVTDFKETKIHSNDILNIMLWSSILVLGSKITSTLSHFLLHPFIHLVFDGSTALYLSAIFIPVYVHFKQSREPLSEEKSRFRLLAYAGIQGLIVGYIQQDSFLLFSDPFAFLGLAVMGLSALFLHPVLGESRLNYLVAVTGSGFAVHFVIGLLFGQLGFIYLLMALLYTAAAFILLQYYLNPAETKAMPHLYMYYNFIAVMYIQLVFYYVFGYTKEDYKKLSVVAEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIF0</accession>
    <name>A0A0N5BIF0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIF0"/>
    <dbReference type="WBParaSite" id="SPAL_0000573400.1">
        <property type="protein sequence ID" value="SPAL_0000573400.1"/>
        <property type="gene ID" value="SPAL_0000573400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000573400.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23060" checksum="6821DCF4301AC79F" modified="2015-12-09" version="1">MKDDIRLKANFKVHFHPKNGEQGSTIDNEVFISTPFNIPIDDTSTFIICALKKQSKDLTIYFEYEDKKTGKYNRVVENNKFLKNPNSKFKTMIFISETVLESKSQKFKCSVKDEKLQKILAQVTTSYTPDMEKYEFNDAGTKEPIQKNEEKKRSYVKDLLTILIIIMLSIRLFGSIVINFLQRAYFLTFKSNNDEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJK0</accession>
    <name>A0A0N5BJK0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJK0"/>
    <dbReference type="STRING" id="174720.A0A0N5BJK0"/>
    <dbReference type="WBParaSite" id="SPAL_0000612500.1">
        <property type="protein sequence ID" value="SPAL_0000612500.1"/>
        <property type="gene ID" value="SPAL_0000612500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="164"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="399"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000612500.1"/>
        </source>
    </evidence>
    <sequence length="937" mass="106822" checksum="3E9A868EB360CCCF" modified="2015-12-09" version="1">MSKVTEKDIRTLGEKLNDLKTGGDEVIINIERDEELFQDMKALYNWLEILLPNYDFSKNELPAEKFFKINPPTDVCIDKNIQHKIHTYAGENGGIKKFIANWSPPKINYNCWTNMFIADGMFKDKPVEEISGSLRDVDSRKMKDAVMEDLRRKLPVYEKKNEIIKAVEENDVLLIKAGTGSGKSTQVGQILLKHYISQGRGGEFNCIITQPRRLAAISLAKRVAEERYEKLGESVGYCVRFDKVDPRPFGSIVFGTVGTILRKLSSGFRGVSHIIVDEVHERSLETDLLLIFLKKMILNGCKIKIILMSATVGTQTFEDYISGIKVLEITGKVFKIYETYLDEIIQHFEAIPSNFVPPVDYVTNSKFWSFKNKSNKSFVSPLAEYIAEQIEQSDEIPYEIIRNLVLMAREAMIESGKFGSVLIFLPGWKEISKCIKELEKISNEYYWLVPLHSNLSSEDQKKAFELPPADKIKIIVSTNVAESSLTIDDVIYVIDSCRQKTGRLSQKRDKCFYEISWLSRDRMDQRKGRVGRIRSGHCCRLITKKFMNSLPQHSEPEIINCPLDSSILTIKALGLGDSKTFLQDAMEKIDEININEAENNLQEIDALDGNKNLTHTGRILEILPFAPNTGKCILTGLLFNVLDSLSIICTYCDSNASLFNDPFKQVETSKATMELCGDFKSDFILPLMAVQINTGCFKKSVKDLSLSKMLSKESKDRLLKAKKQTGDILHRMFQHNDFRDTGLPSNKESSVEMYTISSLLVKAVFPNIAVRDNKYKFIDNEGTIVLPVENSALTIFRNLYDPESMFILYWQKIISNRRKIKECQAISPMQALLFGYKQFVYIGSSKIKVDDNVIFRGDPKFIQMVISLNSLVDDLLKSLCIKKYLNEKEMTAKAYIKNLIQRISITGCSTNRYKWPRKIVTGLTKVDFRKIGGLTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJM1</accession>
    <name>A0A0N5BJM1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein sens</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJM1"/>
    <dbReference type="STRING" id="174720.A0A0N5BJM1"/>
    <dbReference type="WBParaSite" id="SPAL_0000614400.1">
        <property type="protein sequence ID" value="SPAL_0000614400.1"/>
        <property type="gene ID" value="SPAL_0000614400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF10">
        <property type="entry name" value="ZINC FINGER PROTEIN 208 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000614400.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37037" checksum="1E246B23D4EA1C30" modified="2015-12-09" version="1">MSNLATMTNGSPFNIPSIPVINPFIPPQFQIPMNMDSSMILQNPWNLNNLKQLFPTLNMGSLPKANSKSEEALKNGHTINDNFLNRKVSNNENLKESCMVISTSDSGISSNCDNSSKQFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCEYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCGKAFSQSSNLITHTRKHTGYKPFACDICGRTFQRKVDRRRHTETHHPNEHTPGVTKQPPSENINLSRGDNNNKSSTINILPSTTTLNTMSQFLNNITGNDFLIHEQSKGTYPSQNNSILSSLGSNIFFRDIFEKTLKPEDTKHNLSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJN9</accession>
    <name>A0A0N5BJN9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C76 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJN9"/>
    <dbReference type="WBParaSite" id="SPAL_0000616200.1">
        <property type="protein sequence ID" value="SPAL_0000616200.1"/>
        <property type="gene ID" value="SPAL_0000616200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000616200.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42725" checksum="978D6BCCC2904F07" modified="2015-12-09" version="1">MCQASLGRNNQCTAISSAALIMACIKSLLNWDKVDINNVLNQGNILYERSVNHLRSTNDPIDSRGYLSVTNIIRETTLFNRKITFSTASCYSFVGRGLTVSRDEVVFGYVSLSEALNRLVNRHQFLILIANERTSSIMHHDGAFFLFDPHSMDQYGKYCSNGVACMIMFNTLSDLIEHLQANQVCNNSIFDLDGVNISVENISDVNSDISATKINVKGRQSKIVNKDPLHLFKNSKNKKIDSNLNEEISLLKIRYDKCKRLCEKKKIQVQLNRLEKKSIDTVKKDCIETLKINKIVDNNPIKGSLINNEEPMEIDKCENDASNLLINFDEGIDSTLKEIIVIESKIKNCKRVNEKKKLQVHLNRLHKKLIKKSTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJS5</accession>
    <name>A0A0N5BJS5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Core-2/I-Branching enzyme</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJS5"/>
    <dbReference type="STRING" id="174720.A0A0N5BJS5"/>
    <dbReference type="WBParaSite" id="SPAL_0000619300.1">
        <property type="protein sequence ID" value="SPAL_0000619300.1"/>
        <property type="gene ID" value="SPAL_0000619300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000619300.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="34699" checksum="D5F91B53941506E7" modified="2015-12-09" version="1">MLNTNSTADILLLKNFKLWKPKNFNLECSRIINGDNNYINKIKRKRFTMKMIPKSYKYDCESIKSRGFYSKVPLSDIEANYPIAYARNVYNNFHMLELQFLLSYAPQNYYCFAVDLKSTELYKQLTSLAKCFDNVYVPSKRYNMNSYGIYQAFSTYECMKILINKKWKYLFILQNDDFPIKTNREIVEILKARNSTLDMEFQDPIPFIQNRINQNTSWDYKSLDFFNETEISKYDENLLRKNIKFSKGSYASGMPRDSVDFILNKINISKYLYQINTVNKYGEDEMVWQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKK6</accession>
    <name>A0A0N5BKK6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Crossover junction endonuclease MUS81</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKK6"/>
    <dbReference type="STRING" id="174720.A0A0N5BKK6"/>
    <dbReference type="WBParaSite" id="SPAL_0000646200.1">
        <property type="protein sequence ID" value="SPAL_0000646200.1"/>
        <property type="gene ID" value="SPAL_0000646200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000646200.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49686" checksum="A6F1A7B3AE0CAA53" modified="2015-12-09" version="1">MENSDDDCVILDVIDKNNQCKPNWKNVKKFSSTDNIKPRTTNTVSNDVVMGKKSDCIINSTTNYLKNVNILSSDIQRKDIHSIINYDTKNAETSNKQVLKKVPSKRKLKEINKGDNDDGMETEAQKKKRLRMEAKEAQRVEKEINKIKREISASINTKAEQYLYCRVSRKIIDMIPEFKRSIETFFEGRQIKDQLEFEYSTHNIITWRRKNVDALVENNTVQRVEMFDLENTFLLILSGEEFKNLHITNELITSIDSVKRKFNGEMQGVVIVYGKHSINKPTLYSLCLEVFEKTGVQIKFMKNIEKLIITVAQHHRAIARRPLSLEKNVEGMMVYNGDKGVKDGPDLHKDWWYKMLSAIHRIGEDQKRAIIDHYPNPFDLINLLHEIGAYAVVKRISNIQCENGRKIGSIFAQKLVQTLSSVTGDEIIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLA4</accession>
    <name>A0A0N5BLA4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLA4"/>
    <dbReference type="WBParaSite" id="SPAL_0000670300.1">
        <property type="protein sequence ID" value="SPAL_0000670300.1"/>
        <property type="gene ID" value="SPAL_0000670300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000670300.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58924" checksum="1BE7AF5EB7964998" modified="2015-12-09" version="1">MIKIADFLAKNGHDVFILHAPMNPNTVDTHGKVAKVIRPSTSSKLVEDLFLILNKKLKEIWDVDSLWNPYHTLTIISNYNKWLAASCEHIIKENNLTKSLRNENFDLGIGEAFVPCVFGMFKYYNIKNHVAVMSGIPFDSHYNEIGINFPIGQVPSIFGPMSEDMSFQDRLYNVFFYLTVKYLHNDGVSRGNDIFRRHAPSYNINLENIFTESVFYISNTDPLVNYGAPGSPKMIQLGGFLLEKPQPLNPYFDKILNIRKNNVIISFGTFARSIDMPEGGLNSLAHLFESFPNITFIFKFEVNNFPFFRRFKNVITTTWLPQYSLLNDKRISAFIMHGGENSLLESSRAGVPMLAIPIFYDQPRNAKMISVLHLGRWIEKSQFINDKYKFVGAFKDVFENPLYKESIKKVSRMIKKRPYNESESFLKHIEFACEFGEVKNFNIGNQEMPFYQRTALDIFLFLIICTYTVIYLTISFLKFMYFSLIRKYYTLRQNNKNGLRNALKQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLZ5</accession>
    <name>A0A0N5BLZ5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BLZ5"/>
    <dbReference type="WBParaSite" id="SPAL_0000694200.1">
        <property type="protein sequence ID" value="SPAL_0000694200.1"/>
        <property type="gene ID" value="SPAL_0000694200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="550"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000694200.1"/>
        </source>
    </evidence>
    <sequence length="835" mass="96242" checksum="ED38317723F3641F" modified="2015-12-09" version="1">XNAYFQIGVPAESQKYLAVKTPFGVYQFKRMVQGYINSSSEFQRLGEEILHGLEEFCTNYIDDIVIHTVGSLEFHISKVKEVLLRIRDADLRISFDKCSFFGRSIKYLGFHINENGSTPHEGNIKSFLRRPFPESKKALKSLVASANYYRNYIENFAEITYHLDNLLKKKYRKLIWNDNAKESYEKLITAMSNPKFCHHPVLEDDFILTTDSSNHSIGGVLSQLRNGEEVPISFYSKRLSPTKRKRCATYKELMAISRCFRHFKYYFGGSRIHIRTDHLPLIGIFKNSVDNRYLELTNDLAGFDYKIHYVKGSSNVVADDLSRETYNPNDVDFSGDEDGSDVEVNVIKCVKVADFLDCVNIDAYNIDENSDCEIAVCDELENTIETNVLKNQGDVMIKRKRGRPRKTKALEVENVHPLMELVENKDGILNIDFKKHQKDDEEIQEAIETGMYDGKEISIVDDIVYVKTKQSRKGQELRRIIPTSLYDKVLCLAHKMRGHFGLAKTKHLIEEVGYVKSINAIVKKYIDECDECMRRNSPTILHPKMSHVNQYTMPFQNLAADICGPIIPTSTTGNKYLLVFVDSFSRYTIIIPCRSYSFNEIFQKIMDEVIWKHGNPLSIRTDNGSNFKGEKLMEVFETLGVKQEFSTAYHSRGNSICERALKWIQNTMAKLSKSKRERWDVYAQAVAYYYNTTVCVSHGFTPFYLHFLRNPNTGLETLLNIQKNYNVDRNPELVELVDVAKEAYKEAKLNLENTLKSRPEGKIRDNDLKVNEYVYVKLPDTSCGSKLALEWSGPFKILKVDGHKITIETGKRKKKVVHFSNCKRCKRSDVNQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMX1</accession>
    <name>A0A0N5BMX1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMX1"/>
    <dbReference type="STRING" id="174720.A0A0N5BMX1"/>
    <dbReference type="WBParaSite" id="SPAL_0000725400.1">
        <property type="protein sequence ID" value="SPAL_0000725400.1"/>
        <property type="gene ID" value="SPAL_0000725400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14336">
        <property type="entry name" value="UBA_AID_AMPKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000055">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="60"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000725400.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="68199" checksum="A79268FF04F418D5" modified="2015-12-09" version="1">MNSTSLKLSDKEKSRSDPSKLDRVKSLHRRFSAKFVRKMAFSELSKADKEAKAQMKIGPYILHETLGVGTFGKVKLAIYEGTNQKVAVKILNREKIINLDVVGKIRREIQNMQMFRHPHIIKLYQVISTPTDIFMFMEYVSGGELFDYIVKHGRLKTSESRRFFQQIISGVDYCHRHMVVHRDLKPENLLLDDRLNVKIADFGLSNIMIDGDFLRTSCGSPNYAAPEVISGKLYCGPETDVWSSGVILYALLCGTLPFDDEHVPTLFKKIKSGMFPIPDYLDKSVVKLLLHMLQTDPMKRATIKDIINHEWFQKDLPPYLFPPTNESDASIVDIDALREVCEKYNVKEEDVTTALLSDDPHNQLSIAYNLFVDNKNIERNADRFSKMAMEDYYQPVSGKSLQHHDQKQKIHPERMFNQGRISSTLENLSTSPTVSPGVLSQKSPNVKRAKWHLGIRSQSKPDEIMSEVFKAMKSLNFEWKLLNPFHVIVRKKPSDPSIDMPKLSLQLYQVDNKSYLLDFKSLVDEETPDGSGPSSRHTSISMQMKPSFRVSRSSSISQNISPDTMESTPPPSPHIGVKQSQTMLFFEMCASLIETLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN08</accession>
    <name>A0A0N5BN08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rac GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN08"/>
    <dbReference type="STRING" id="174720.A0A0N5BN08"/>
    <dbReference type="WBParaSite" id="SPAL_0000728900.1">
        <property type="protein sequence ID" value="SPAL_0000728900.1"/>
        <property type="gene ID" value="SPAL_0000728900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="314"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000728900.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58115" checksum="52AA488AAB93895A" modified="2015-12-09" version="1">MFKRNGLDTMFNSTLDIVSHYESLTNRSRSSSDDCKNCNYIRNQEDDKKQSTPSRFLRSYKSKIGNKENNLLSIEEELRLTEAKLRQARAEIVYLSERNSDLERQNDELIKTIKALRGSYTTSAVISEQDIGDDGNTASPAVTCLDEKDTMFYNETDRSSVIKRFAEYSSSSISLGKSGSTRKRSLSTTSCEIESKIKKNNGFSTPQKFTGKDKNIFDYNTDPVKFVTPIREMIAHLTKKWARYEDIENNPHKVVKPKVLVGYCDICETFVLKGKNCLTCTECNIFLHNSCMKDAPIPCVPRPPVTSKHPKIRPSLLDFCPRLHPMIPYIVVHGVIAIEKYFITTEGLYRIPGAGCEVVKLLNNFKHNRVIPDLKSCAAETITGCIKKFLRELREPLIPTTSCLEFIKAVKSRDLEGLNFAICNLPSPNRDTLAYLCLHWKKVASLAHINKMPIENIACCLGPTVVGSVVKTNEPFLSKIEEEARDQNNVIVQLLNLTEEYWKQILEGKLNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN75</accession>
    <name>A0A0N5BN75_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN75"/>
    <dbReference type="STRING" id="174720.A0A0N5BN75"/>
    <dbReference type="WBParaSite" id="SPAL_0000735400.1">
        <property type="protein sequence ID" value="SPAL_0000735400.1"/>
        <property type="gene ID" value="SPAL_0000735400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF137">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000735400.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43117" checksum="CEBF2D408F87A4D5" modified="2015-12-09" version="1">MDEQLTIFALMNAIKMANVNDNVKSEDLPPTPEKESSPTSNHCYTNLNNFANNQILEAVKAQIMLNSVFPMDQTLFTNFLATATPTLQEQNRNNVFEGCNLTPFLNHNILPTSLNGISNQNHINDMTNLLKNLCNTRQGIESIGDNEKIAINDFLHTNMTEGRLVSPSIKNKPKNVMNDAEKEEIEEFALHFKNSRIRFGFTQGDVGQQLGHRYGTDFSQTTISRFEALNLSFKNMCKLRPLLAEWIVVTDEMLKSGKTAEEINQKKLHSKYGQRQNIINESPVMDCENNIISSDEIHGKRKSSLDGQVVGNLKKRRKRTNLDATQRDLLNQLFERDERPDHDAMDKIANHLNLDKEVIRVWFCNRRQKTRRIVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNE8</accession>
    <name>A0A0N5BNE8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <shortName evidence="2">6PGL</shortName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNE8"/>
    <dbReference type="STRING" id="174720.A0A0N5BNE8"/>
    <dbReference type="WBParaSite" id="SPAL_0000742700.1">
        <property type="protein sequence ID" value="SPAL_0000742700.1"/>
        <property type="gene ID" value="SPAL_0000742700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000742700.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26575" checksum="B846C79DB8450FDF" modified="2015-12-09" version="1">MVSITLTPDETVPYIKDLLKKTIEKGKSKKTVYIGLSGGSMPKTVSESLKQLLEESLSIENVKFFMVDERVVPLSDKDSNCGEYLNLLPKHLEGHFIPITNFEDEIIAAEEFEKILKEEKNLEISQTGFPIFDLLLLGLGPDGHTCSLFPNHQLVKEKVKWIAPIRDSPKPPPKRVTITVPVINNAINVVFLATGESKKNAIKEILVNHNADYPPSLIKLENGMDITWIIDHDPFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNM7</accession>
    <name>A0A0N5BNM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel subfamily T member 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNM7"/>
    <dbReference type="STRING" id="174720.A0A0N5BNM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000750400.1">
        <property type="protein sequence ID" value="SPAL_0000750400.1"/>
        <property type="gene ID" value="SPAL_0000750400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000011">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000034">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="267"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000750400.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121781" checksum="4A5F758F884CF37E" modified="2015-12-09" version="1">METDKLMSEYLPTSNSLEPIKNTNYSASPLNPSISRSAQELRERARLQYGEEKGLKSRLHEYFLVNYKSSLRIRTFNFLIKTLSCILYCVRVLNDEGNSLDDENFSNSSEYSEYFPLVVSVFLKAGREIYVPIFLNCWLANGILNAILNDINRVSNVKHSAVSRQYVILLSTLICLVFTGTCAIEHLQRAGKNKLDLFTSFYFIIVTFSTVGYGDVIVDTKFTRLIVVSLIVAAIIIIPSKVETLAQTYLEHKRTGVDCTQGFSQGDKHVVVTITHFEADFLQNFLTEFYAHREHQGFIVVLLSPSELDDKTKLLLKIPLWSQRVVYICGSALKDEDLERAKMSTAVACFILSARHINNKVTTDEHTILRSWAVKDFANHVPQYVHVFRPETKLHIEYAEVIICEDEFKYSLLGNNAIVPGLSTFITLLFHTSRGEEGQKSPEPWHKIFGFHSGNEIYDIRVGDSRFFGDYIGKSFVYASFYAHKSFGVCLIAVESSNGEIKLNPGNKHILEVDDRVFYIALTNEESLSNFKKDINKQKKSINKTLYIAQLQKPIDQGEIEKQSHTRQQKTEKTKSLFQKARAITAFKSNSPQSMKNSPSTIPNIGQVTGYDESSSDEDDDETILHDNADEYFSNEIIKSYPPVAVYIGTSPVVCHMLKKQRPICCLQIAEPCEHCNFRTANEYNFPSQAIIVAVDKTSSGLYNLIIPLRAYYRPVEELHPIILLLELKETQTPNPAFLDAISWFPMIYWMHGKISNLENLLKAGVCNANSIIVIKEGYTDVEEHLADCSTIITVQKIHRMFPTLRVITELTHASNMRFMQFDAYNFYALQQSKFEKREKKRGSQMPFMFRLPFAQGNVFSANMLDRLLYQALVKNYLIKFTRLLLGIEQTSGSGYLTSFRIAREDLWIKNYGRLFQKLCSSCSDIPIGIYRTKKMDSKTISAELEKMKRDEYGNKSDANLNNFYRDNLSRVVKEGMQHLGIICDDYQCKYEEKEKLSYVIINPSHDMEIEEGDIIYIIRAPVKESATSKKINPKRGLIKKETQISKEINVLSNYASQYNEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP96</accession>
    <name>A0A0N5BP96_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP96"/>
    <dbReference type="STRING" id="174720.A0A0N5BP96"/>
    <dbReference type="WBParaSite" id="SPAL_0000772300.1">
        <property type="protein sequence ID" value="SPAL_0000772300.1"/>
        <property type="gene ID" value="SPAL_0000772300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000772300.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43813" checksum="85D5B3CEA72503FF" modified="2015-12-09" version="1">MVFSNNILFPSIFVFLIIFLQTILVSISKCEEDGRFTNISEDYEVCREAMGFGKTKFVCDPDHSLKLDTIAKLEALLRELQINVKCPCALGCPSRGQTGSDKFIGLLQVTTHDKINRTGRVFEEAAKDIYDKEMLGSNECDNGIMILFTRDNNQLAVYSGEGKFTVLNQSDLNKIHDFATKGVLPEHGVALQAVLQSMNIATGGNIEEVKKSENTPMLVGFLIALLLFFIILALLLSLCLSKTCCCFTDKHKERKGEYIVNPEHSTTMRSPEPVYIVPPSEYHISPIHEDAIYSSPYAIPPIYTISRPTTPSSIHLNKIKPIYGDVSTLGKIQSPVKSSFSPTSPSKNTKTTISDDDSNSTIPITNDHPHDGTYQFLDPRRSMEIQTKEDFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPF2</accession>
    <name>A0A0N5BPF2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPF2"/>
    <dbReference type="STRING" id="174720.A0A0N5BPF2"/>
    <dbReference type="WBParaSite" id="SPAL_0000777800.1">
        <property type="protein sequence ID" value="SPAL_0000777800.1"/>
        <property type="gene ID" value="SPAL_0000777800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000777800.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24870" checksum="9BACDBEF42133E02" modified="2015-12-09" version="1">MSDILYGGYQHEPEKVKTAIKNLEHKVLEIRMNIESTLEILNRQQSVPFEELMGLFTSLANTMTQMQTLLKRSALTASQDDSGAFLRSHLLVPQAISLDYNETLHRKTEGRIPYWNHDVVPEFLSTKISAELEAIDKGIESEKNLKSQELVTRQINQMNKHIDILLGALNEAGKIAAENHTSKPTYDNNETEMMVRAMMNGEGLHCRSQLSSSSATQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPU1</accession>
    <name>A0A0N5BPU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000791550.1">
        <property type="protein sequence ID" value="SPAL_0000791550.1"/>
        <property type="gene ID" value="SPAL_0000791550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000791550.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8369" checksum="FBAE41CD6860ACB2" modified="2015-12-09" version="1">MGPKLLLLLIKQGNDNTTLIEKVTTNDGMEDGFGEENDSVVKIDDKNVIKEIIKNMCRDVYDYEMNNIGNDMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQR8</accession>
    <name>A0A0N5BQR8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQR8"/>
    <dbReference type="WBParaSite" id="SPAL_0000823000.1">
        <property type="protein sequence ID" value="SPAL_0000823000.1"/>
        <property type="gene ID" value="SPAL_0000823000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000823000.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25691" checksum="AFA3E7BBB9E6435D" modified="2015-12-09" version="1">MGLNLISLPPDVLAHIFSEIPWNQLINVKLAARKFNYVTEKYHKNMQKPSLFTLFLGNDFTHNDGIDRIRITYSFVKADVDPLESVSDTKHFFLPSSEPDRLHSFLQKFGDIYFLDEMGIFLDNHTDVVQIFGDHLHKDFGANDMYVSANNSEKDLGTTLSFLQKLQKVHNLELDLHFPHLSVPKDFIIPVRNSLNSIVIRERENTTFISTLKSFLIIILVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR96</accession>
    <name>A0A0N5BR96_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR96"/>
    <dbReference type="WBParaSite" id="SPAL_0000839900.1">
        <property type="protein sequence ID" value="SPAL_0000839900.1"/>
        <property type="gene ID" value="SPAL_0000839900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000839900.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="50453" checksum="408A100304E472A1" modified="2015-12-09" version="1">MYRRDPIQDQRYYHHKNDIRKKKKDSIALCCCNIKDGSMTVAIWSSIYALCLLFLFGWQTGVLSQCSEVTMAQANLKCEYYCPCVGASTARTSRIIEGLFIIQIICLIVAFFLLFASLALIYGVHNVSRYLIWPWFPCMISSILTSTAYCIIWWVGDVRDYWLAITICLIILQFINAYCFVVIIVFYGRTGKDGLLRDEYIGGQPVQDVYGGNDEDDYEEEVKDYPPPTKDITYDKGKLDYYNDRQFIEDDKIKRESLERRKRHGPGNGEEHDKVSEVKTTICHCSKCRRGRGERHHKESRRKRQYSCCEEESNNGTDTTYYDKKRYHYDDRSCTCKYSHRKSTICSYCRDYRRRQRKKKYRGYKPHTSTIPKHLFYSDVQRGKKTPQLGDNLMIPQNIFIPKTTGPEVDEKGNPVVNKYVIDSEFTFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSF2</accession>
    <name>A0A0N5BSF2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSF2"/>
    <dbReference type="STRING" id="174720.A0A0N5BSF2"/>
    <dbReference type="WBParaSite" id="SPAL_0000879500.1">
        <property type="protein sequence ID" value="SPAL_0000879500.1"/>
        <property type="gene ID" value="SPAL_0000879500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000879500.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45735" checksum="D53FB2AB26C1C92A" modified="2015-12-09" version="1">MFKDHKVAQLGLFLQLTSWFLFYCSPRTLSNCIETTLFLIALRWYPFHEVEWNKNKGSWKYIVIGMISIIIRPTAILLWIPLGSIHLWRTNKRLSLIFKNVLPSTIFVFLMSVILDFWFYEKIISSLYNFAMFNVFTGGSAFFGTNPWYYYLVDGLPAVLTITLPFVVGYFFVRSSNASNDLIYAGIFYVFFHSLLPHKEHRFLLPIIPIANIYGGYYLRSLITKRQMKLFLTLISITCLINISCAFFFSTIHQSGPLKMVEALRSKINDSDSVNVLYLTSCYNIPQYVYFHDKPDVSIRALDCSPNLEMKENYIPESDEFNSNPLLWATKHDDLINDANYIVIYQHNFELIKDILLKHFLICHKQYHGPILANEHEDHYLYLLCKHQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSF4</accession>
    <name>A0A0N5BSF4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSF4"/>
    <dbReference type="STRING" id="174720.A0A0N5BSF4"/>
    <dbReference type="WBParaSite" id="SPAL_0000879700.1">
        <property type="protein sequence ID" value="SPAL_0000879700.1"/>
        <property type="gene ID" value="SPAL_0000879700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894807" evidence="7">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="8">
        <location>
            <begin position="91"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000879700.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49181" checksum="1DC117A2D77DC277" modified="2015-12-09" version="1">MKYYYLFFIILLFIPLYEGRRLRNNGKARSLLNSQSSTSSPHISSEKDSNSFVDAHNINGEEEIFTEPPWTDKQIVEEILKRYRFPDSSSNISVAVFVMIDKFLPSTPDVCSIQLKIKQKWLENRLSYRNFRDSIHPIKFRSLNYIWSPSLNIDNAISMTGLGKEDIKVYSNGMIEYEQKYQITVDTHGSLSNYPFDIKNCSILFSNDDSRASWSYLSNADVSGANIRMVGGWQAISWSRGHHSLLITLKRNVQTLLFNYFIPTMLLSFVSVIPIFFSPFSKFNRIIFGSIIFMTTFLLTLYNFGSIPNTPYLKAIEIWALFTNIFTFAALTESIFITNCAFQKIQRPPTLKASRSNYYEENDERSRWINEAPYYSQMSEESPSYIGRLSDCLFRFIFVLSLISFITYFVLRYYIPYWDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSH3</accession>
    <name>A0A0N5BSH3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSH3"/>
    <dbReference type="WBParaSite" id="SPAL_0000881600.1">
        <property type="protein sequence ID" value="SPAL_0000881600.1"/>
        <property type="gene ID" value="SPAL_0000881600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000881600.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48293" checksum="E0AE9DC7D72B9958" modified="2015-12-09" version="1">MGGPHLLYTCSRTYKSIDNLIKHCKSTHNLPGMGKLHRQVQITELQNVKLMLEESDDEDLMNTDYETDTEVVNFQSLSRMRRNTAPAPVAAPVAAPVPVPVADSTVDQHEPMDVGIHNNPPDVITDTSTVESNANDSLMKANWVETFILKFLYKTPFSDSTMESVIETIRSIISKVCDDIVTICQNNQPANREVLNYISDLCEMSCMTNLVKKINGREEIKEKIVHVDTAARGVDEPPRAYSAFYLSLKDSIERYLNMKHILPYIQFPRPSEQNIIDSCLCGIEYKTLYNQYKKFLVVNVYIDDVSLNSPIGSCSDNNGITNVSYSIPNVVRRRCTLDNIQPFIVTLSEHAKKNSYQEIAKIIKNEFEGLEVRVGEEMIPCKLFMLKGDNLAVNSILKLSASFSPKSATNQCCFCLCTYDQFQEHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT36</accession>
    <name>A0A0N5BT36_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT36"/>
    <dbReference type="WBParaSite" id="SPAL_0000902900.1">
        <property type="protein sequence ID" value="SPAL_0000902900.1"/>
        <property type="gene ID" value="SPAL_0000902900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895124" evidence="3">
        <location>
            <begin position="22"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000902900.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="81407" checksum="62499272D925B549" modified="2015-12-09" version="1">MLVKFLAILLLILEIIQFKYSVYGTPKDQDKVKLFEHNCDNTLEEPHHEETLTIKFNQLEKYETGQKQYKNVRFSEIKIVKLSWDSMKKKAINSDELCGLGLKTVEKELIKYDDESTSYINIKDNYHISYSNGYLKGNNFEDYVEAEILCNIHQCDMGLLFFDEDKNAETLNNVNEIHMVDHAVLVVIESKDNKMLLGTVLHHKVDIILGICPYINWVPEKGLLQFIPEEGIKDNGYFEKENDKAHIVVPFYKKNEDSDEFICGKLKQPTMPDLLIGYKLEEYISDVKIEGVINPLENELKCEHSDNPQHHYHFGYLEKSTNYMSERIMEAVTAHDHNSTHKFYAGQKIYIYNRDNIEEGLENGDNRERLTEPFVYEEALCIKNLKSNIKASILPTIGSLDSIKKHEEKNIFYRIIKSNDFGKEHSFRCLTKVEEENKGHMEEFYSRSAEFIVENGGKPTVVNTLPQNTITFIPKKINNYGSYRCKDIKATSLFDKNFITMNEVYYLPDEDSEMELEETPVVDTYQSNVGCNKEYGTIGKIKKMIIGFAQNVSEPIIISNFTNDIDTIDIKEGKIIYKKLKDVLGVTVKCTYETPAETTFYTTKTIIIKKTQDTGTKDRTIPKEKALTKVKIDSTPWIIGTMVSVILFGIILYVVVFLIIRKIKKTKARNSLALSSSSGLSTPSKSKGSKSSASTIHDKSSYESVTSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT44</accession>
    <name>A0A0N5BT44_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT44"/>
    <dbReference type="WBParaSite" id="SPAL_0000903550.1">
        <property type="protein sequence ID" value="SPAL_0000903550.1"/>
        <property type="gene ID" value="SPAL_0000903550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000903550.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7240" checksum="8702A65BEE9B4640" modified="2015-12-09" version="1">MTLRQLFMINKGRKVIKNDYSKNGIFQADILKDFTEAQLNIFFLTYAISNDIIDSDFVGKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUY9</accession>
    <name>A0A0N5BUY9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUY9"/>
    <dbReference type="WBParaSite" id="SPAL_0000965700.1">
        <property type="protein sequence ID" value="SPAL_0000965700.1"/>
        <property type="gene ID" value="SPAL_0000965700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000965700.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28685" checksum="0C5BF0D1F31F38C2" modified="2015-12-09" version="1">MIRRSAITIPSFTSTIPITTITTIETTKISTTTRKPSTKRKVTTRRKATTKKKKGATKREGTTKKRKTTKRRSTTRKKKSPTTTTISTTSLITTKKPSSEIDIKSLRRNYLIQTNMYRQLHGSPDLTNNEELENLAQAYAERLGKEYNGKLIHDPDKRYGENLAYVPISMIVDPVRLWYNEIQNYHYENPGFGLNTGHFTQLIWKNTKEMGCGIGKVNEKYPGYYIVSCKYNPSGNYEGQYKENVLPVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVZ3</accession>
    <name>A0A0N5BVZ3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVZ3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVZ3"/>
    <dbReference type="WBParaSite" id="SPAL_0000999900.1">
        <property type="protein sequence ID" value="SPAL_0000999900.1"/>
        <property type="gene ID" value="SPAL_0000999900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000999900.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36018" checksum="576F028D4FD5CC3F" modified="2015-12-09" version="1">MARYSHKMSVSSSSVSRKYSTPTGGIHSKSGTYRKNSRYQPTMNSRKMSAPVQKQRDEKRKLSSTKSAQSHKTSTGSSVSRERQSSKTCCASLSFGLYDIGQESNTVIEFISHCLSSMFPHKLMTFIYIVLLVFSSFSAYFGLQYINKCPIKPEISIYLLINGILSILQLSLLLMHHRRKYHDDFEDPSENTTFSHFNNSASISQRRSYSASISTKLILSLISILLFGSFIIGNVVVFSVYRPPSRQNERSLDPTNWCNEYVYNWALIQIFFIHSIIIFSILLIIVLFILSIKFMFMSTNDVAMDSGGATDVLNQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWH5</accession>
    <name>A0A0N5BWH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmotic stress resistance protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWH5"/>
    <dbReference type="STRING" id="174720.A0A0N5BWH5"/>
    <dbReference type="WBParaSite" id="SPAL_0001017000.1">
        <property type="protein sequence ID" value="SPAL_0001017000.1"/>
        <property type="gene ID" value="SPAL_0001017000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001017000.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="64973" checksum="15CEC05A21109C6D" modified="2015-12-09" version="1">MLLKIDYLIYEKYKKIPIEQLASDAVFEQAEQAKMQPKTGNKFIDMLHENGIPIGSSLKGIEQALKTQREIENNDPTEQIAKAVFEKFQKQILPGLVANMIAGKNPFQMPGGGPMPRMMQQNPMPINPNDPPIGSELVKYLRESFDKSLGRLQTNQFAMNPVIAEKMGNTIRRSETKLSSSNNDDYIDDSEEMEIVQKSENKSENNDKYTEKENFDDVFKRIRKPRATNVEDTIKEFIASDPKAALVLGLNDMDLDDESGVTTSVRKSPIELSTNLKKELVPMMTLDEINYALADPEDLLSPIKPLVSPNPQPGFAIPRKVPKRPRKMLPLMIGVANDNDFLENNKKNPLSDESHEIDIEEEKVNSSNGEKITSISDETRKSPSKLSQYRNKQSRVLENLKNNPGLVALFEGTDLAEKLDKPLVISNEQRGYINTRGNEITTYPRMYAAKLFGDEPNIYDKKTKQIVEEHEIPPLFFIPKGKHTRLRWITANEQEIPGIGSRFIIPSLDPTRPAINSVMSTQGKERNEYETTWKIPNEWRSGDIFGISMNTKSEKLIGGDGVVDFPAMGRDVIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWM6</accession>
    <name>A0A0N5BWM6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWM6"/>
    <dbReference type="STRING" id="174720.A0A0N5BWM6"/>
    <dbReference type="WBParaSite" id="SPAL_0001021900.1">
        <property type="protein sequence ID" value="SPAL_0001021900.1"/>
        <property type="gene ID" value="SPAL_0001021900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000033">
        <property type="entry name" value="NEDD8-conjugating enzyme UBE2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001021900.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21438" checksum="4A6F4EDE33FEF319" modified="2015-12-09" version="1">MLNLRDRIKGKNENKEYTRTRIEVRDRLLAGEMSDLQQALAKMPSCSLSFPNNNNYEMRLIITPKEGMYYGGTFEFEITVPMEYNNVPPIVKCKTRIWHPNINEQGAICLSVLRPNSLDGHGWMPTRRLIDVIHGLDALFGDLIDFDDPLNIEAATQYQKNIGLFKTKVQDYIYRYASSKSSRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWS7</accession>
    <name>A0A0N5BWS7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWS7"/>
    <dbReference type="STRING" id="174720.A0A0N5BWS7"/>
    <dbReference type="WBParaSite" id="SPAL_0001026700.1">
        <property type="protein sequence ID" value="SPAL_0001026700.1"/>
        <property type="gene ID" value="SPAL_0001026700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000002">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="81"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="642"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001026700.1"/>
        </source>
    </evidence>
    <sequence length="829" mass="94647" checksum="FE36107A6FB8B9A1" modified="2015-12-09" version="1">MNIIGIFVYYPIELVQRKTFRETRRCVETRMALVKENEKQENILLSVIPKHIAWEMKRDFDVNDDTRLFHKIYIRKHENVSILFADICGFTNLASECSAQDLVRTLNELFARFDEIAHQNHCMRIKILGDCYYCVSGLPDGRPDHAICAVQMGLEMIEAIKLVRELSGVNVNMRVGIHTGKIHCGILGLKKWMFDVWSDDVTLANHMESGGLPGRIHITEATLNALNGTFNVEPGNGDTRSTYLADHKVKTYFVVADENKVVIPHQQTVTKTSKKCFELTGLDKPGNQKRDISKGIDEEVENYLMQGIKAINKESWKSQYCKPGSLIFKKAKMEEKFLRYKENSVLGQISCALTIFALASGVLCTGGLFNEKVATAGATSVVIIITIVGYIILRNILSHQPKQYHLSRFYKFIFILGMFFLSTYFIFLQFFIDPVSNCHFKCTEKDDNNTAIIYGDGRCTSNESFDHLPIEIILDCTLLIMLSVCVFMSLLALEKMLITIFLCACCLIAIWFVPFPDLMNSQFFLWAKVNTELDKITLLEKMSQYCIDGNNTDNFLKYSFTFLVFFAFVLISLQSRRSELIARYDFIWKLQAIDEKVEMEKKHQQNRKVLENILPAHVANHFLTTLPTNRSELYSEARDNACIIFATLTEFNKFYVELDGNNEGVECLRLLNEIIADFDEILNREEFSCIEKIKTISTTYMAASGLSGNLRGNRHVVAVVKYAIELLKRIKYINHHSFNNFNLRIGINVGPVVAGVIGMDKPHYDIWGNSVNVASRMDSSGIPGKIQVTEEVKLLLEKENFEFECRGEINVKGKGIMTTYFLKLSPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX81</accession>
    <name>A0A0N5BX81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prefoldin subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX81"/>
    <dbReference type="STRING" id="174720.A0A0N5BX81"/>
    <dbReference type="WBParaSite" id="SPAL_0001041500.1">
        <property type="protein sequence ID" value="SPAL_0001041500.1"/>
        <property type="gene ID" value="SPAL_0001041500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001041500.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14024" checksum="28D4F82BCD566C24" modified="2015-12-09" version="1">MSTDFDHQLRQAFQDLHLKLSENSSQIRATDQMLAQAKHEYRYDSLVKAQIIDAGKERPIYRSIGSAYQLDDYDKCLERLTNSIASNKDRITALETKKKYLEKTVEDAEKNVREILQTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXP8</accession>
    <name>A0A0N5BXP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001057000.2">
        <property type="protein sequence ID" value="SPAL_0001057000.2"/>
        <property type="gene ID" value="SPAL_0001057000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895138" evidence="2">
        <location>
            <begin position="17"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001057000.2"/>
        </source>
    </evidence>
    <sequence length="469" mass="55041" checksum="57EA0BC21BDAFB04" modified="2015-12-09" version="1">MKYFVIFFAFFLLIESKKLIYHHYTLISTPFKEQTIEVDQNNDVIINYVKGQNVLIIFEAHKNVYLFGDNIHIYHSNPRDKKQFNYFIQRDGINCALFIYNIGTNLSSSSFYFKNIEKNFEYKFIIQHKTPSVISKEMTDIVMLGGTSIKYFGERQYFEVICYSNKPLKNKDSLSIETFGNSKAPKSIDVHNRNMDGHSKNYFDIRIDSHKMINKYSTVSYICKNNDNYVVETIITTYDFRTKNEMGTKKSRFFKDNLFLIVGCSTLLLILICIKFILPMYKIIKEKTKKREQDICMNGTNFFLNYDLTENLSTTFDSYTKAERKEFDKQCIFTESDVRITYVLIKFPEQTSSIYLINNLTLDASVSFWKFAYSKNIELVVTLAPCFNYTNAKNSNDHFYEYAPGYFPEFIFDMIVSMKEKQKTDFTGIYLRDFEINKLDIGKDGGNNTITTSILXXXXXXXXXXNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY46</accession>
    <name>A0A0N5BY46_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY46"/>
    <dbReference type="STRING" id="174720.A0A0N5BY46"/>
    <dbReference type="WBParaSite" id="SPAL_0001070700.1">
        <property type="protein sequence ID" value="SPAL_0001070700.1"/>
        <property type="gene ID" value="SPAL_0001070700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="369"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001070700.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="80667" checksum="DACD8F486C9EE183" modified="2015-12-09" version="1">MILRKSKKILREENKKKVEDFMKAVKENDSFRDQIVSENEKKQIDDVYKSFDVSDVKLIYEPECKDVEIISSEVTIQEKLSDSHNEIDNLKSDDKDNTVQQVNSNNSLDMNSVKSKNLSFSNSIYHTTLTVDGNLTDPINGYSNKLDETLEISREKTYLMRNSIISLNSTTPVQDTSNQISQNLNDVCGLPEINNQAIFEEPKNKTYSSSDDEGSLRFVTIERGNTVKDSKISSKYKNQKDQDKQRNSIFYHGKPRRKVPVRCVIPIDDDFYDGTVFFKESFHIENKIDDEENVKCNQRFSLPKKRKSNERKSCISASKRELTEVPSLEMSRYFLDITQEDLTASIMTIDDMLKLMGQEKLVSFRKLLPQKIKKIGEGSFGEVYSAKNSKNQNVIYKVTPFEPDDKTKTMVNGDILKGCRELSVEYVVTNEMSKLSEMSNFCCDNFVKLYRGIVVKGMYPKILLDAWKAYERNNEIFNEDPLEYKDKVNYYMILELEDAGIELEKFDDIKRPQAYSIIFQLIHCLRIAETVFLFEHRDLHESNILIQKVDKDVDIEYKYNLNEYKLKSFGVKIKIIDYTLSRMNLRNEEYFLDLDKVNGLYDENCDPDTFQSVYLKMRKITNGDWSKFYPKNNLFWIIYHVKRLFSLKGIEDREFVNFFLKDVSEMECLEELINNDKFINFQKKFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYA5</accession>
    <name>A0A0N5BYA5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYA5"/>
    <dbReference type="WBParaSite" id="SPAL_0001076600.1">
        <property type="protein sequence ID" value="SPAL_0001076600.1"/>
        <property type="gene ID" value="SPAL_0001076600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895041" evidence="1">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001076600.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30557" checksum="E9BA3163804E0FA3" modified="2015-12-09" version="1">MIYSKFPFQYFIIFLFICSVTSFKEERTKNGTILTSNVKYSATQTFTVVGEPNISRKCRCSEVDYCREKSFTSRKQCVSSCSHFLQYFADNVEKTVDICFNEHQDDYKSEKKYDCTLFNFCTKDNGKDTRDVYIPKYNLTYYHMHYRKIPTANIFSETPQNKKNLLTFSYFKKFQHCLHSCVKYIANTCYNNDKKCSVELNEFNKQTARQIEYCTCMSVNVHIYMKKGCTCMHEKMKIEKLGGICELIGNHIFKKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYR4</accession>
    <name>A0A0N5BYR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYR4"/>
    <dbReference type="STRING" id="174720.A0A0N5BYR4"/>
    <dbReference type="WBParaSite" id="SPAL_0001091300.1">
        <property type="protein sequence ID" value="SPAL_0001091300.1"/>
        <property type="gene ID" value="SPAL_0001091300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001091300.1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5866" checksum="4A230038728255B1" modified="2015-12-09" version="1">MMEAIFGTRKTPAEILRANQRALNKAIRELDREKARLEAEEKKVVNEIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYY4</accession>
    <name>A0A0N5BYY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYY4"/>
    <dbReference type="WBParaSite" id="SPAL_0001098200.1">
        <property type="protein sequence ID" value="SPAL_0001098200.1"/>
        <property type="gene ID" value="SPAL_0001098200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001098200.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="46390" checksum="52D443B8E56BFFBA" modified="2015-12-09" version="1">MNDYRSEKIPLISNMSTENQEPSTNMTINKNEEYTEKFTTYGIFIVSSYIVLFFTRIILIGDANFVDNVINNFPSTENFIKDEHKTMSHYCLSRGEPCLAAYRNIQEDFVRKFIVAPKYKMANCIMPKCMSTVTSKIFSYLYDTEEYLKFNWQMNGVSASHHKNDFSKMENFINKFVYGNKNNLKDWQLSVFIREPLDRFISAFIDKCYLEKDILSLGIFYPGSELCYGCNKNMSCYLTKQYTRSALYSRSLQRVVGYEDQHTFPQNWFCNFGDYKNIYTVYKTKSDKEGKIMYKNTIINMLKKQNVEEDKIEYIEKFILQNRKNITDPIEIKLKEKRKTIRNYNELPTILKNELLSDPYMYKLFISMYYYDYLVFDYPIPFPKFNQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYZ0</accession>
    <name>A0A0N5BYZ0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYZ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001098700.1">
        <property type="protein sequence ID" value="SPAL_0001098700.1"/>
        <property type="gene ID" value="SPAL_0001098700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001098700.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58992" checksum="F60A56EED44E3AFC" modified="2015-12-09" version="1">MEEDSTTNNLTLEKILDVGLIFNKLKNEYLSSADVFNLCLTSPNFCDIISSYATKMYIDVDCDFDSYSFNNATITGPYPYFIRTEDVGREKNTFKFVFEKPKKTMYIELGTLSNETDLNNKIQDYSEWFLDPTYRAIQFTSCKSQYFEQFMKALCSSESSSITTLEAFPLVNVVENYLKLNETYTVELDGFSSLSRIEYELDGISKIAAFGERIAHGLVCGLKNRPGASIHLNWRIPQYEATLSQKRDDIVHLFETIFCKCLEYGISVSLAMNVNVIKMVSEAYNKYPVNITSLKIYSYIENSPSVVEYLTGTKEFFGTTKSFTINFSCPCAGGKKFIGLGVIKTMKSLERLTANFCKFHGTSERATDIFNNSPVNVKYLFLNNFSRYDQNIFERLSSNAPELKSLIIDSNKKHIHNSSTSSYFTSFRKLISLRHDCLQRIVTYPNSLKILVIRCTLENQNCFCGTFIQEDLSFKHHTVFVVGEYHKIHFYHNNFKQLLDYLVFDSELIPTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ64</accession>
    <name>A0A0N5BZ64_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ64"/>
    <dbReference type="WBParaSite" id="SPAL_0001105900.1">
        <property type="protein sequence ID" value="SPAL_0001105900.1"/>
        <property type="gene ID" value="SPAL_0001105900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001105900.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44816" checksum="BE33C76E48B1640E" modified="2015-12-09" version="1">MKRLELLFLIILVYFTITNNSVLSKKPKKKKPSKTPTNSFVMNKTIEYSIQKTLKYAGDIRFYHGLFENETCINFIESDVASLITATLIKWGDKCSVSADLVGGDIAYTINVNKECNDRDRFLKLIYWSVELRYQFTKCLESDRHYRPGHIKEHTMQDVLKKYKCKIDALGEAEQEINRFQVIISIKKSPKKSGVEPADLEQRDYNKELSFNNLIYLNKQICSNSCKDKKYSRKKCYNYGFKKSKNCYVCICPFFYTGKYCKDYMKPKKTHYCPKSYLKSSSTTKTLILDLKAECYYIIKPSSTKYKKVKVKFEPIGNPIHWKCSLGKILEVKYKKDKSIDGVMPCGHMRNFTVTADKGTTVLVYHDRIGTDFQIKMEYKEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZF6</accession>
    <name>A0A0N5BZF6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZF6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZF6"/>
    <dbReference type="WBParaSite" id="SPAL_0001114600.1">
        <property type="protein sequence ID" value="SPAL_0001114600.1"/>
        <property type="gene ID" value="SPAL_0001114600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895143" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001114600.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23412" checksum="0369455DEAF93D5F" modified="2015-12-09" version="1">MNKFLIFSLILILFPIYQGAFKLVPIEESDDNDELINFNGVDSETKEEKFLRIDEDADENLSFDEFLHSDMNYEKVKREEFESYDKNGDGVVTKGEYFNKQLEDAEELKNHRINYIKELFEEFDIDKNNKLNEREIENVLRKKFLLKPKTNFNNVVATYDIDGDSEWDKEEYAAFDKKLPFEEFDSIIAENKKVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZF9</accession>
    <name>A0A0N5BZF9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab-1A</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZF9"/>
    <dbReference type="STRING" id="174720.A0A0N5BZF9"/>
    <dbReference type="WBParaSite" id="SPAL_0001114900.1">
        <property type="protein sequence ID" value="SPAL_0001114900.1"/>
        <property type="gene ID" value="SPAL_0001114900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001114900.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25347" checksum="C97E3859815ADDD4" modified="2015-12-09" version="1">MSYNYLFKIVVVGDHNCGKSCILLRFVENSFRNDHISTLGVDFKLKTIKLGGDKVRLELWDTAGMERYRTIYNSYYHSAHGIMCVFDLTNEKSFENIENYWLKQIRTHAPPNAVVVLVGNKADLENERKVDFDRAENFAKKTGISLYEVSAKTGINCEEAFMDLANHMKERLINANINEDSDDSDAYSGAFHVDGVIINDKSSGSAFSNATSNCCNGASKPSPTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZY2</accession>
    <name>A0A0N5BZY2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4105 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZY2"/>
    <dbReference type="WBParaSite" id="SPAL_0001132000.1">
        <property type="protein sequence ID" value="SPAL_0001132000.1"/>
        <property type="gene ID" value="SPAL_0001132000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001132000.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31194" checksum="93DC8D3443B86262" modified="2015-12-09" version="1">MDSNFEAKKRQDTIIEDDNISIVHYTSFKKIFCSILIRLVLAAIFLGIAVAALIYAFSSSEKNRESNHGPNIPGETYSMYISQNCSNGYMRIEEKILKANSNDSQQFKVTKIGSSWHQDDIKKRIVHRIGLESDDWMYTYFVFKDHAYLDEPGKCTKVNNVTYDSYIKNMGLLDMRKIEDSVGIHDGKKIIETLEYEITPPLSVLYNNTHPTVSTLYLDENTYASLRWDLRFYERSSSSLLNSVNFYFLNMEQGPQDDNIFYQYSDNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0F5</accession>
    <name>A0A0N5C0F5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0F5"/>
    <dbReference type="STRING" id="174720.A0A0N5C0F5"/>
    <dbReference type="WBParaSite" id="SPAL_0001148400.1">
        <property type="protein sequence ID" value="SPAL_0001148400.1"/>
        <property type="gene ID" value="SPAL_0001148400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001148400.1"/>
        </source>
    </evidence>
    <sequence length="1029" mass="117529" checksum="2B3EE44D0CCBC1B0" modified="2015-12-09" version="1">MTGSLAQQPLPSIPTIASYLKQGDENKRFKKNSSDNVNSTTEVIENSTNDSYPSVVSISSKIFSKGDNNITMPTPQHLQYNSPMPLYSRESAEEQYRQQTVGIDAQPIPLPAPDRHFDPTKSKTLEYIKSGVNDEDFITPHFFDKVNQAEAPNVPLAPEPVWAREARARSERARSKTPANYGINSYYYDQGQQNYHGGRQEYTQKSYNNPSQYMESGFYNPNQKYTSSTYNQIPLDDYNKQKDNIYTCGPNLPPPERPFSSYKNSPYYQSSQQRYTTYDSPSNKGYQFGGMDFIDHNNPQFQSPNDFYVYNQEKRSSSVGKEVRPGYQCGGTDFRKEDIPIGYNPNYHGHAAERPRLRSRYDADPRIPINNYVAPNVEGVDPVTLVGDTISNQRVSRNIERTDEQKKYIGTIFAPAPGHTSNLRSVSPLPKTPEPICYSTNVETLEKLRSKSVQPRSATTTPAFQQSGQHYYNNQNNNWAPQYQENYTKEVNVKTLLTDEALKPIRRSHTPDWSHRSHQKHVAWQNDVVDPRYTRPEIHSQEPNWSKTVNQRRNHWENKIRDTEARVQLPASFKVPPPQNPHWAHHANQKHQIWEAAANSTGMNQQQNHNHHYNNTSRSQECNIYGNNQRSGNYHYTEDRHSTYSRTATGEPAQHYETHSHKDSHTPKQNVTTNTAIPLQPPLNFKSSHQQQGNQIHLHTESRQNQFPSNKVSHESTKQDVRSTIPLPPPSNFSSNNDNVIYHFTEDRHEKYSCNKTGEEPRAYETHTHRECHTPNRVSTPITSAPIIPIDNFKPKVNSNVSYHFKEDKHEKFLSSKTGEEPKSYETHSHREFGTPSGGIQKNTTYNYSTTPATITNSGGAIQTSSWNKKTTEKTTTRESVERPIPAPRYNVVHDTSSIYKKESTNNSTKNVTTIDDSRNNKGHNTTTIYSCSGNEAHNRLAEMNETLPIGSISNTISNTSGTYKDDEGKDVIYKRELTTSANPGKDYQLLKEQETRVVEKPLEPGIISRHVTTKYYKKKTVTDSTTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0L9</accession>
    <name>A0A0N5C0L9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="9"/>
    <dbReference type="STRING" id="174720.A0A0N5C0L9"/>
    <dbReference type="WBParaSite" id="SPAL_0001154700.2">
        <property type="protein sequence ID" value="SPAL_0001154700.2"/>
        <property type="gene ID" value="SPAL_0001154700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16200">
        <property type="entry name" value="EFh_PI-PLCbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000052">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000047">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="15">
        <location>
            <begin position="771"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="890"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1168"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1107"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001154700.2"/>
        </source>
    </evidence>
    <sequence length="1401" mass="160239" checksum="0556DCC4CF347757" modified="2015-12-09" version="1">MAKEYQFNWKPNIPQSFIDGCIFDRYDDESTFLDLNANVKIDEYGFYLSWIVDGKDTNLIDLVNIWESRPVTGPPKDGRILFELEQRGSRETLEERTVWITYGQDLVNINSFYIVAQDISTAKIWRNGINEILKNLKIRHVCPTTNLMKHWRFLCLGLNDRRKIPIKNIVKTFSSGKPERMVLKCLSDLGLAGDKYTPVKVIRKSWTKNLKSFYKCRSKKYHKKKEREELDVELFTFEKFLRLYHKICPRTEVQELFVKLSGQKEYLTRDKLIAFLNDEQRDPRLNEILFPHFTVNTAQALIAKFETDENYINNGKMSGDAFLRFLMSDENSPIFLDRTEMYQDMDQPLSHYYINSSHNTYLVGRQYGGKSSTEIYRTVLLSGCRCVELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLYQIRDTAFARSDFPVILSFENHCSKSNQQKMAKYCMEIFGDMLLSKPLPDFPLEPGVPLPPPSRLKRKILIKNKRLKPEVEKVQMEQFLREGKLDEDDEITENPDVVSEDATLQRTTTTTTYPTTMTSCGSSLSVTSDNASILSLISSSSATAGGSIVSQLSFRRHHHYHNYLSRGKDAFERNSSFRIPSSAYNTSSGSTISSRNITSMRLSFRNKSPNKSGSGTNTGSMDGFYSSRLAGNHQIHSVSENASRRQSTFNTCMFNVSDNSLASNSEYTSSKDYFTSIFSKSPGLDGKEQDEAHPELKQVNFISKLKPLGFKKVQPILTKEEEERIIAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEQNNLNFHMSSYSESTGLTYLKQNAPEFVNYNKRQLSRIYPKGARVDSSNFLPQIFWNAGCHMVSLNFQTPDVPMQLNQGKFEYNGNCGYLLKPDFMRRPDKTFDPFSESPVDGIIAATCSVRIISGQFICDKKIGTYVEVEMYGLPTDTIRKEHKTKTIPTNGLNPIYNEDPFVFRKVILPDLAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRTETNMATVLPTLFVHIVIKTYVPDEHSGLVDILADPRAFYKPSKQEVLRKLVDDDIDGEQMGNGQGNAKLENGPSVDRSLGHSSIHDKTTPSTPMSGVSKNINNGNNSSSIDNGKTSQPNSSRSAPETSDNKFKIKTIDVEEIKKDKVFVKLMKKQQKDVEELKKKHGKQRDSIQKQQQTNVDKLIHGGNRMSKKKRESEKRSGPFTSRDSLSSRSTEGGLSPEELNSVKMKSLVSNQTDEWSSLLHKQAIEEYDQKKGHIKQEYETLKILLLEAQKHQMALLKNNLDNEHKELKQQQTKKSMDDIKSIQQDKNTKNKAERDRRIKELNEKNVKVFVEERKRLAMKAQNYEEQLQMRHQNQLEVLEKELCKALESEKMSHQETLLSIRPQSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0M1</accession>
    <name>A0A0N5C0M1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0M1"/>
    <dbReference type="STRING" id="174720.A0A0N5C0M1"/>
    <dbReference type="WBParaSite" id="SPAL_0001154900.1">
        <property type="protein sequence ID" value="SPAL_0001154900.1"/>
        <property type="gene ID" value="SPAL_0001154900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20819">
        <property type="entry name" value="C1_DEF8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
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        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047983">
        <property type="entry name" value="DEF8_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001154900.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46941" checksum="DA021EAC12D2CCBF" modified="2015-12-09" version="1">MTTISDLIKLLPEVREGVDTYMKNDENFKNVENAEMHAIVKTCNNLLTDEKRKDSITFREEVMSLLVATKWELFQLKDPSINKDEFEEVICIKDHQFVRRPDFGDNPTCECCRSQIWRRLQNYYRCKLCGFKCHFSCTNNVHRKCMGLKFRSPDFKVILDIRPETSLYEQNFQCYDCGKEIVLDDLDNKCEMAKLCDYTGKYFCSKCHWDDEMPIPARLALNTDSRKRGVSRSSKEILQYIFRKPLIKAEDKNRTAFCIDDDLNPMKKYREDIMRMKRYFSACNHASCCEFVKLLRGFQHYIETSDLYSLKDLYEIKKGKLVENLGKILTNFRKHISSGCDTCEKLGYICELCSDKEVIYPFNEGVVQCCYCSNGYHIRCFLRVSAKCPKCERLKSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1G7</accession>
    <name>A0A0N5C1G7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1G7"/>
    <dbReference type="STRING" id="174720.A0A0N5C1G7"/>
    <dbReference type="WBParaSite" id="SPAL_0001184200.1">
        <property type="protein sequence ID" value="SPAL_0001184200.1"/>
        <property type="gene ID" value="SPAL_0001184200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF30">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001184200.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24570" checksum="E08644F38A77CF71" modified="2015-12-09" version="1">MKIAYRKPSAEDLDNINYFITNIFAEVEPVSKSLGLCKECFGGWANSPEISIPKESLDSGLSLLVEDEGKVIGARLVSICRRVTNVDEDNVIDFKGCDKCLDKEDKFNRFLKMFSKVRNSVWKLVPPDVNVLAHREMSGIKTEYQRKGIGRQLAEKDFSDDFLKTLGIDGIISETSSIANQHLLKTLGFKPLNEEKYSDYDIHPVDGSTSLILNFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1M9</accession>
    <name>A0A0N5C1M9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1M9"/>
    <dbReference type="STRING" id="174720.A0A0N5C1M9"/>
    <dbReference type="WBParaSite" id="SPAL_0001190300.1">
        <property type="protein sequence ID" value="SPAL_0001190300.1"/>
        <property type="gene ID" value="SPAL_0001190300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="80"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001190300.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48662" checksum="8C809E141D49627A" modified="2015-12-09" version="1">MDGSINGAWGELPELPYIGDYEPDVNTPQRDVPSDAFVDAFKKKLKNKSMKIKQFLDEHSDNLYLYVEQLKKFASSPGGLISDEYREKIWPVLARSYPSDFDYIKNSEDSESDSDYDTVSSTLDAEYDEDYIEPTIEMLQLHKDWKQVQLDVHRTLERFPPFIDQEKRNVLMEELTPFIVKVLYRNRKFHYYQGFHDVCLTIVLVVGLDIGYEICKSLTRKGVFTNYLKKSLEDSVMKQLELMFPIIYKRSKVIDKALKDSNMTCIFALSWPLTWLSHSLQNYEHIILCFDLFLSSHSLMPIYLSSALILSREKEIQECENDMGLLFGILNKIPKNCQIHEIIVDAQNLFQDYPPLNLKKRLMNEYLEDRKTPIPRPKDPIPRNYTYGFLVASGVAVLAAFYLYIHIQNSVFNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1Q8</accession>
    <name>A0A0N5C1Q8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1Q8"/>
    <dbReference type="STRING" id="174720.A0A0N5C1Q8"/>
    <dbReference type="WBParaSite" id="SPAL_0001193000.1">
        <property type="protein sequence ID" value="SPAL_0001193000.1"/>
        <property type="gene ID" value="SPAL_0001193000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF414">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001193000.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="62436" checksum="85FBDB58CF9FD89A" modified="2015-12-09" version="1">MTALTFIHYKKTQFQTITLLILFLLVFFGLTFKVIEVFKFLNVKIILCIGISIGYLYHELYWKRKNLPPGPVPWLVAGNMPQLLLSMNNIDKKFSQWKDEYGGQYTVWMGPIPMVFVSDIDTMKYYFIKHGDHFSDRWLNYITDTFMEGFNGVLQIHGDKWREQRRFSLHVLRDFGVGRTEIERRVMFEVEKMIEVLEIDSGSNALDLHSYFAACVGNIIITILFGKRYDHDDPSFIELRDLLEKQTQIVVQPIMGLYCISPLSTKIPFLNSKWIEIMTIKKKLFNFIDEQINEHISNFDPSSEPTDFTYAYLKEMHERKSSNSDIGYFSEKQLRSLLLDLFFAGMETTVTTLKWGFLYLLRHPEELQKVQKELSELPNIIKMNDRNNLPYLQAMTNEIQRTANILTFNLLRTTSTDVLIDGYYFKKGTMVLPMISIVMNDSRYFENPQQFNPSRFLDDKGNQKKLDGFMPFSLGKRQCLGESLAKAELYLVLANLLRNFDIKPDPNNTNPSTKRMLGITCSPQKYKLLISKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2A4</accession>
    <name>A0A0N5C2A4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NNMT/PNMT/TEMT family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2A4"/>
    <dbReference type="STRING" id="174720.A0A0N5C2A4"/>
    <dbReference type="WBParaSite" id="SPAL_0001211500.1">
        <property type="protein sequence ID" value="SPAL_0001211500.1"/>
        <property type="gene ID" value="SPAL_0001211500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF17">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000384">
        <property type="entry name" value="PNMTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001211500.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32109" checksum="A8205D3AF495C842" modified="2015-12-09" version="1">MSEAKEIIVDEDIDQAISKLTLYSAKEHDEMFNPQHYLEGFYKTAKEDVAMQIVLFFLPGIIYRLPDKIENILDLGAGPTVYIPIALRKRGQNIFTSDYAKVNREELKKWITNDKNCFDWSNVCTWIANIEAIYDNPEEMQDEAREKMRAVLEVNVFEDHPIKNVYYKVDDDISVPKQFDLVTTIFCLEYATESLKDYETAVKNAISLIKVGGYLLQGGVLEANEYSFGETRFKCFHLKQDVLTKTLKENGMEVDEKTGNFKLIEHDGIFILISKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2V5</accession>
    <name>A0A0N5C2V5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2V5"/>
    <dbReference type="WBParaSite" id="SPAL_0001231200.1">
        <property type="protein sequence ID" value="SPAL_0001231200.1"/>
        <property type="gene ID" value="SPAL_0001231200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001231200.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11808" checksum="D3B901CF01F0759D" modified="2015-12-09" version="1">MGLGNSKQQETINIVNENQQLDNSGDVDNHNKIKNDVFANMGGHVQFYLAIIGFLFIAYNILRCYCLSIGCKPSMKNLIPKSWRIQAETSPTTAAAGTQDRDIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C351</accession>
    <name>A0A0N5C351_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C351"/>
    <dbReference type="WBParaSite" id="SPAL_0001240600.1">
        <property type="protein sequence ID" value="SPAL_0001240600.1"/>
        <property type="gene ID" value="SPAL_0001240600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001240600.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16407" checksum="DC9EE9FB3EFAD4F5" modified="2015-12-09" version="1">MLKFLSSVISNSKKWVTKKQIDINNRVAIKDKLSKLNFPKYQQNETYNKVLRKFVENKGNIPKLRSMVSISNNSEVKERSLFSLKDRPTIKAVMLLYGGFKRIFRTIFLFRKYKIKTIYKVITTILLLNAYGLFKFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C3M6</accession>
    <name>A0A0N5C3M6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C3M6"/>
    <dbReference type="WBParaSite" id="SPAL_0001256700.1">
        <property type="protein sequence ID" value="SPAL_0001256700.1"/>
        <property type="gene ID" value="SPAL_0001256700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001256700.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40618" checksum="3E66E0D0EB570924" modified="2015-12-09" version="1">MCHGKNLFEENHKTISVFSPENDYSKTDTLQVTIVNEKPNLYPGQRLQIVTLLDIQNSYPKAGKYLGYVINYEPKCRVPYLKVKLYLKISETIQNFENKADDTFGKINIYVVDRRGINNVSVGCHVVFEGKKHPAFNDFYENCCQPSLLMRDEKTNNLKEVLNIQSLEPNKKYICALKVKNAILTNEKQKFIHDTEFTIHFTDPSYAKWIILGVSFSIILVLIVGLIILKKSQLRKKEPNNSLSTDTSQSTSTTSTIISRVSNVPIIQKKGAVKKCTNTPKTMVTQNSSTNNKGINFGQKVVGNNSNLINQTKNAPKKIATKNSNNNLINQTKNTPKKVVAKIINQNKISNVGDSVFKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4A6</accession>
    <name>A0A0N5C4A6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4A6"/>
    <dbReference type="STRING" id="174720.A0A0N5C4A6"/>
    <dbReference type="WBParaSite" id="SPAL_0001278700.1">
        <property type="protein sequence ID" value="SPAL_0001278700.1"/>
        <property type="gene ID" value="SPAL_0001278700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001278700.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="84672" checksum="E26E6F5440F1B241" modified="2015-12-09" version="1">MIHGVDNFLKRIRESEITNGVDKMNYLYTVLWLLLISSIGISRNMVGEPMQCWIANQVTRWESYIENNCYLRGGYRYSNRSINGYTEIEKIPVNYYAWVQPFTIFQAICFALPFLAWNVISIQSDFNPKKIVQNATIIKKNMKFLEFVQGNTMVIAQETVDNLFKGLKKKSFYIESGKKSSCFQFLQCSFLTNCYMLFKLTNLLNIILQIYLLCSFYGIPKFYSAGVDVLFGNSDENGIKIGNSPYFPRIITCNVTLHDVAYSTPTIVNDCVIRVNLYNEAFFIITWMWYVTLFLTTITDFQAWIVNSYFPKVRNSFIKSHLMCRNVTLNDREINEFINKTFYTDGVTMLRWIAAKSGSNFTSDIIHVAYKKYFKDKKDEETNLSVYCHTPLEIIRGGWERYTSAQCFLNGKFGNSVEKKKFSMYYYAWTTYLFIFPIIFFTLPRLFWSYVSKEYENGIKNLLTISKNSTNHFQKAIQDYLKQREEFEGRQKVVKMEVEDTDEGKYMAFSRFRKNLHKDSIAKKYLIYKFMLFIASLVLFWYIKHIFQVSSNSEAIDFISKKLNDTKYDHPHLFPTKVWCEVIVNDVKYSRQQLSRFYCSMPYNYMYQVIFGILYLYTPFIIMISGFSFISWLYAIYYKPYRTNYFKNLLVLMNHNHVEDKHFYLFISHFSKTDYVFFELVSEKISSAETAIAIENVFLNYKKQSIAANNNINTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5E3</accession>
    <name>A0A0N5C5E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exported protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5E3"/>
    <dbReference type="WBParaSite" id="SPAL_0001317200.1">
        <property type="protein sequence ID" value="SPAL_0001317200.1"/>
        <property type="gene ID" value="SPAL_0001317200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001317200.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16702" checksum="15B57EE85CCC1DA9" modified="2015-12-09" version="1">MDNSKIFFITSVTIGGIIGMIYWFSHTKKDKDIENENEIVEMDEVFVDDKKKDDQEVNDKSTNNESDIKSINSYEEVLSIESSEHSFPVTPISSPTNKENFKKSKIPVFQSGPGQVNVDTIPYSIPSPSISPGKGSKLLEPKITRKNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5N8</accession>
    <name>A0A0N5C5N8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5N8"/>
    <dbReference type="STRING" id="174720.A0A0N5C5N8"/>
    <dbReference type="WBParaSite" id="SPAL_0001326500.1">
        <property type="protein sequence ID" value="SPAL_0001326500.1"/>
        <property type="gene ID" value="SPAL_0001326500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040369">
        <property type="entry name" value="ARMC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048959">
        <property type="entry name" value="ARMC9_ARM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14881">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN ARMC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14881:SF4">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN ARMC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21050">
        <property type="entry name" value="ARMC9_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="2">
        <location>
            <begin position="339"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001326500.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="89532" checksum="0CDDFC4369357359" modified="2015-12-09" version="1">MKSNDNQYESNQKNNSNEKNNRGDESRGNESKDESKNDNNEIGGNNGQRRDGNNDKNNNNNNRRNNNSNNNYKVDENKSDDNDDDEKNEAKKSGRISTIENVKSKRSSYPNGKAFNRSNLTVKGVGNFNNLKNIERNDSRKIALFSIPKNSAKGIDKNNIKKTESLITINNKDDKNIEDPSNVNEIAFKPIVKRLHYTKIVTTLLKNLNSRNTALLLQALRQQITRKENKEASIEVIKVFAFKDILNLRNANNSIVYNILLHHDSKNHIIKEEFARLLNAIASFKVGRAFLINFSYGKNFIYPSVVALKNKRLDDITSSHILAAIQKVSIKPVVQKELLQQNILDWLVKIIVQESISSTFFDFGIALISNLVLNPFVQSHIIRITHDLVMMLLIILQRNNFKDKNIIYGIMYVVLELRKVRVKVKELKVDEILYKHLKVSTSYEEKCIIAFLLCCLLEEYDYGNKKVYSLSENDDNWDDYIEAEIESTDRLRPGALECFGEKLLIEKFQIRNDQKDIYCQAFAEIDRKSTDMYIDSPQVPLGTVTNKNSSFSLNNPLSRTTTTASSKHNLKIISGNKQQNNIYGRTSRSLSRSTPKINDSNKPPNSTTSFKTFILENDKRKPLILPCGIKSAVLENLKLIRAKLTSLNIPLECDDNEGSRENKINLPSKDEIKKYFVIPKKVNIEKTFVIDKKKPIKSISIYKKNDLYSNENFKNELFSKDKYNNTLQIETFDNTSTSNPPQFDGPHDDIDIDYNSVFLSRPKVLRTPDKVNLSKDDFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C752</accession>
    <name>A0A0N5C752_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C752"/>
    <dbReference type="STRING" id="174720.A0A0N5C752"/>
    <dbReference type="WBParaSite" id="SPAL_0001376700.1">
        <property type="protein sequence ID" value="SPAL_0001376700.1"/>
        <property type="gene ID" value="SPAL_0001376700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001376700.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11298" checksum="D3834EE153149E63" modified="2015-12-09" version="1">MDAVGTEISSSIDQPLDLIRLSINETVLVKMRADREIVGKLHAFDQHLNMILSDAEETLTVTEFEEDQCEEVFKQVKRVIPMLFLRGDSVILVSPLLKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7W4</accession>
    <name>A0A0N5C7W4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C7W4"/>
    <dbReference type="WBParaSite" id="SPAL_0001402600.1">
        <property type="protein sequence ID" value="SPAL_0001402600.1"/>
        <property type="gene ID" value="SPAL_0001402600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="307"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="850"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="1120"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001402600.1"/>
        </source>
    </evidence>
    <sequence length="1566" mass="178973" checksum="D1F5CF85B7ACC87A" modified="2015-12-09" version="1">GHYAYLAKELVPLTNLLKGAKKHLEWDSSCESAFSQAKLALKNVCRLKLPSDEKEYILHSDASGDALGSTTGIERFCTSGVGFFSRRLPVLKGFVPAVELELKCIAESLRYFNQWIYGKSVKVWTDHKPLLKAVETNCQRNLMKHISDIREYNVTLQYIAGPKNIVADAISRAYVRRIDDADESCITQVVKVIGEVKLTMDNPKEKKIQKNDVVEISDNVQKEKVISTIDNHEEADVVIDECEKELIFKEFHDKLSHAHSDRIINLIRARKNWPSLAKDLREYISKCRICLERNIKKKVKLNAETVVATKPWENCNMDVLGPLDVDSEGMKYILGIIDQNTRYLILEPLKGITAKEILAALEKGLIYRFGSPLKIRCDNARYFTSNLLKDITNLYGTEIQHGTPYHHESSAAIERVFRTIEDGLSKEAEGNAADWSKFIPQVQFHYNVLKHSSTQESPFKLMFGYNALFKYDFENCRGKIPYIMDHDDEVRTREASWNLAKLAVENANKPKDEDRVYNEPNLHVGCRVLIKNHKNKSKFASRYESGYMDFMRLSDSDRIKLGVVVATLKACDKGNRISSSRLSVLGLDNLKLAEAREKVRIYKCREIVSAEIGNQLPSILEESISQLPESSESETDEMGRMFMDLDDFDETKMSMSSFLRKFEKCLKFDKISDDKEKLDALLVKLTDDCAREVEKATGYESARTTLLERYGEDMTEDHAQSQLQYFKFDLMKESILVDLKQFARLVRITLPAVSGKDLMKSTRSMMIMRAQEHHHLWTFLMNLKSPETVQQLIMEVEAWHRLTKSKRDAERRVTRQPAKFAKNSSTFTNNGINKTTTKDVKSDKTKTVQCYECQEYGHYSRRCPNKTSKDNQMVTKRTLVSNAKVKKNANDNSTIISTDNDLCSKHDVENDVILRSANKSYDFYLPVLFENNHVELMLVDGGSTKTMIRYSVAKGLGFKLEKVKRVILANGTSWECLGSMKVRLKFPGNIICDVLAWVAKDSELKEMIIGSDVLRAVKAVVSYDSETLRFCGREIKHSQGNDRKKVIARVISVEDSKQVRSLIEEKFKDILSTGSHDIGRCKVVAPDFEVTCRDPPRIPRYPLPVSSVSSAMKQIQEWEDKGIIVEDRFCKWIMNLVIVQKKSGEDRICLDSRPLNKVLIGFNYQSPLLKEKCSALNGCNYYTTIDLVQYFHQIPVTEQSSKFLGFKGPNNKTYRFVVLPFGIKHATAIGQRIIDLVLQDLPYAFAYVDDVLIATKGDLKLHYEHICRTMEKLREFNLKINGEKSVYAAKTIDYLGFTFSERGMEPNSKGVEAIINYPRPKSLKSLRRFLGKINFYHGHYAYLAKELVPLTNLLKGAKKHLEWDSSCESAFSQAKLALKNVCRLKLPSDEKEYILHSDASGDALGSVLMQLQDDNQLWPVGFFSRRLPVLKGFVPAVELELKCIAESLRYFNQWIYGKSVKVWTDHKPLLKAVETNCQRNLMKHISDIREYNVTLQYIAGPKNIVADAISRAYVRRIDDADESCITQVVKVIGEVKLTMDNPKEKKIQKNDVVEISDNVQKEKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C980</accession>
    <name>A0A0N5C980_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C980"/>
    <dbReference type="WBParaSite" id="SPAL_0001446300.1">
        <property type="protein sequence ID" value="SPAL_0001446300.1"/>
        <property type="gene ID" value="SPAL_0001446300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="424"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001446300.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56451" checksum="A47DE6CCEE082BA1" modified="2015-12-09" version="1">MASLTKINNDSRYKIIKNIQQQIEEKFYPQLLSLTNAGEKWLKTIEDMTSASKTYLTALNEFSKSSPENCEGAKVASYETKEMAGNFDLVLKEYTESIESIRKFVAKLQVQSKKEKSHIATMKETFDQQVKKKNALLKKKKLTDNDVQEFLNVSLEEHENIAKIRYDFIARFNREITKKQIEFYKNALQLIDPSYSNTRHNTLSKNDARNLIKEDDLKDVKKEDENLELELIEAAEEIKNIVQEEPINNVINIQEIHTTDTESIPSRLTPATVELVHEELPESPFVIETPTPDHPIITIEDGNKNITNDDNENNNNIMKQKQMIEEFEKKVEEVRQKNAPPVVMPRVTKIRNEVKKVVHEQHQHHRHHYHHTTTSPITIKDESSAVKHYSSSFPDNKIYHDRIPIPAPDYDDKPIPIFKYNTWEYGNLVLAKIYYSPRSKAELGLEKGKKYFFMKGGNRGWIFCRDLDTSRSGWCPSDFVELYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9K5</accession>
    <name>A0A0N5C9K5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9K5"/>
    <dbReference type="WBParaSite" id="SPAL_0001458700.1">
        <property type="protein sequence ID" value="SPAL_0001458700.1"/>
        <property type="gene ID" value="SPAL_0001458700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001458700.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45239" checksum="DEB0AB7057E39B08" modified="2015-12-09" version="1">MFSNVSKQFDVNINGIDCYNNGTGYKISLDELSNLLNKDIGCFLVGGLKITRFETIASNMFFKNNFEEVTVKDGISEVNVKIIKEDVKESVKKIYMDNNYGGILLFISFNLLEGVVGNLYLDEIYILNDFAVASEIFKLEISLVKRALNANLFNCTSFSYLSQENGFCKAVYEKLNSDKNTSELLQTNEGIRTSFCINRYGKSNSTINISNLPQSGGCKEATVCNIYEESDNDKNTSELTETDKNTRTSFCNIYGKFNSSGSVPNSPQMDECIKTLFCNENIPETPRSRRVNNMLDTCTRKRRNLEMHSHSPSCVKKKKLSSESPEILSQHVDKDVYSLQTSDVIRAIEYGIASSKSGEVRIETLRIFLGARKLEFARFLLKLVDRYELIDEFTKIVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA72</accession>
    <name>A0A0N5CA72_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA72"/>
    <dbReference type="STRING" id="174720.A0A0N5CA72"/>
    <dbReference type="WBParaSite" id="SPAL_0001479600.1">
        <property type="protein sequence ID" value="SPAL_0001479600.1"/>
        <property type="gene ID" value="SPAL_0001479600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF23">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895842" evidence="2">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001479600.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21673" checksum="9B5F6B1755277778" modified="2015-12-09" version="1">MKSYIVGIVFVALSIFVITNADTEKPKENPLSRGWGDEVEWVPWDDAVEIALEQNKPIFLLIHKEWCQACQNLKKIFKQKNAQKVFTTLSKFFVMTNTQDEEEPHEDEYKPDGNYSPRVLFLDKRGDVLEDFVNEKAEYKSYKYYYSNPSHIFDTMKKVIKHYGKEVPQLRSTKKLVPKNKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAR9</accession>
    <name>A0A0N5CAR9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab-10</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAR9"/>
    <dbReference type="STRING" id="174720.A0A0N5CAR9"/>
    <dbReference type="WBParaSite" id="SPAL_0001498800.1">
        <property type="protein sequence ID" value="SPAL_0001498800.1"/>
        <property type="gene ID" value="SPAL_0001498800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001498800.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24989" checksum="DDCA3B5E537D465B" modified="2015-12-09" version="1">MNNQMTKKNSVMHDVDYQFSIMLLGDSCTGKTCLLIRYKDDTFMNSNFISTVGIDYRTKYVELNKYKIKLQIWDTAGQERFRSITNQYYRDADALLLVFDITVRSSFENIRNWLSQVEEFAKDGCVVTLVGNKADLSSQRKISASEGKELAKAYNINYIETSAKTGLRVTETFHDITKKLLIRDLSQDKSTDINKINLNSTSSSSSWYTISCCESSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB61</accession>
    <name>A0A0N5CB61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB61"/>
    <dbReference type="WBParaSite" id="SPAL_0001512350.1">
        <property type="protein sequence ID" value="SPAL_0001512350.1"/>
        <property type="gene ID" value="SPAL_0001512350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001512350.1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7756" checksum="F5B3AB6B2F844D4B" modified="2015-12-09" version="1">MKTSLKVKLYFIIFQFKYQNNVYIYIFKNIIKHQRLLILLNEKKNMHLISVALENKVCEFFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB74</accession>
    <name>A0A0N5CB74_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB74"/>
    <dbReference type="STRING" id="174720.A0A0N5CB74"/>
    <dbReference type="WBParaSite" id="SPAL_0001513700.1">
        <property type="protein sequence ID" value="SPAL_0001513700.1"/>
        <property type="gene ID" value="SPAL_0001513700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="171"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001513700.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="53001" checksum="29DA07CB16C21071" modified="2015-12-09" version="1">MVNCFKVLTEEIEEIDDSSDEEDVEPSNKEQALNKIDDDIPLLQKLYFGSEENFDKITMEEQLSDPFIKEAYEEKMYDKRKIIELNNQTMIEDLTGMGYVIMVPNSKIGTVLNIAHNLSGHYNAEKIFRWLKDVCFWKNIFMDIQLHVERCRECMLGNDIRSKNYNQKSVIFSGPMQSISIDICGLMNVISHTGNRYVLGIIDNFLRFLIMTGLKDLTYTSIVNSLFKELFFRHGIPEEIHNDNAKSLVNNKLTSLYQMLNIKQATGTPYYKKANVLIERAFRQLHNICTKLITKETAQDWDELLLPMTYFHNTMMHDTLKCTPYEIFYGRSCRTPLHVMLGKQSNSLFDKDVDRWELTKNALKAYKHVEDTIVECRDKENKKKGGKDFPSFEKGEEVCIRRPPNKDEKIIPHKFQSPFIGGYKVFEDLGSKLKVHKGTRGRCLIVHKSDCKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBC8</accession>
    <name>A0A0N5CBC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TOP4c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBC8"/>
    <dbReference type="STRING" id="174720.A0A0N5CBC8"/>
    <dbReference type="WBParaSite" id="SPAL_0001519100.1">
        <property type="protein sequence ID" value="SPAL_0001519100.1"/>
        <property type="gene ID" value="SPAL_0001519100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF62">
        <property type="entry name" value="DNA TOPOISOMERASE 2 TOP-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001519100.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32876" checksum="39496F65FDF7C9A2" modified="2015-12-09" version="1">MFVHLQTFGYPALIQDYKEYHTETDQIYEQSFVVRKKRYIERKEFLVGMLEAQSKRLINQARFIVAVNKGKIIWQNRLKSIVDQLINEKFDPDPVKAWKDHIKKKELEMCGEVEMEKEEESEDNETSTDAGLREHLAEYSYLLKMPFKKFSEEEKDRLLKESGGKLVELEELKKKTGADLWEHNRKVLEEALEKQEEKELQDIEDAIKTAQSKLVKGGAPGKAKKNKVNVDVSSFKPNPGAEMVTPVEEDNKKGAKRKSTAPLKVKKTKRAKIKSDDDEDFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBW3</accession>
    <name>A0A0N5CBW3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mariner Mos1 transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBW3"/>
    <dbReference type="STRING" id="174720.A0A0N5CBW3"/>
    <dbReference type="WBParaSite" id="SPAL_0001537500.1">
        <property type="protein sequence ID" value="SPAL_0001537500.1"/>
        <property type="gene ID" value="SPAL_0001537500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001537500.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="16035" checksum="F697199928701EBD" modified="2015-12-09" version="1">MDLYDNRKRSWQYVNKNEAQKNFLKPSQNQKKVMLSVWWSSLGIIHHKFFKPGETITGEINCQELAELNKKLKKIRTALTNKSSPILLHDNARCHVSKKNFKKLYELNYEILPHFPYSPISLLLISIFSNIWIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC61</accession>
    <name>A0A0N5CC61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC61"/>
    <dbReference type="WBParaSite" id="SPAL_0001546900.1">
        <property type="protein sequence ID" value="SPAL_0001546900.1"/>
        <property type="gene ID" value="SPAL_0001546900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001546900.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="20009" checksum="5959B2B43C846966" modified="2015-12-09" version="1">MKKIEKILRTELFNHDEQTTQEILNFLKKCEAVRKFEEDLEKEQEKLDSDFEDLHKILRLISSAPAFPHHHPMVNGEDEEENDDGRSAPPYDKEEEKKNSEKEDGENDEEEEKKTREEEINIIEEEKKSGKEEEKNTGEEEKNSRRRRNRGRPKKRVYPWLKYHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDD0</accession>
    <name>A0A0N5CDD0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDD0"/>
    <dbReference type="WBParaSite" id="SPAL_0001587500.3">
        <property type="protein sequence ID" value="SPAL_0001587500.3"/>
        <property type="gene ID" value="SPAL_0001587500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="56"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001587500.3"/>
        </source>
    </evidence>
    <sequence length="393" mass="45910" checksum="4573E912E3B3E394" modified="2015-12-09" version="1">MYRTLDYDYKTIVETLNKSLEQSNERPICGYTEEINFLRYLYTSFASFIATIGLFLNISMLYIFLKKFNDMKDRPFLYSIFLTILDCLICILFILIFGVDVFAGFNKIESLFKIYHEYIIVVFILSKITQLSIPYLLILSTFERYAVITKKWNNSNIFTIKVRIFTLVICFLFCIILKIPSAFSIVIEEYPNCSNPFRKLAVDISDFAKNSLWYSIYDFQIMCLIQQVIPFVTILILNLLNVQQLSRNIKKQKSQIIVDTSYRASNVTGFTLAHLQVLHYQNDNQLNRKIVNAVYSTLAICFSYLICNGAHLILTILERTGSNLLVDESDETKASLFYTTFGDIVSFLYMFTSAIRFVIYYKYNNDIKDEILSIFTMNKANVTREKHLFCENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE46</accession>
    <name>A0A0N5CE46_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE46"/>
    <dbReference type="WBParaSite" id="SPAL_0001613600.1">
        <property type="protein sequence ID" value="SPAL_0001613600.1"/>
        <property type="gene ID" value="SPAL_0001613600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001613600.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27279" checksum="664291C5B2616AC2" modified="2015-12-09" version="1">MDIKSVLFSSLLTWNAQSNSYNLGNTWNLCGISPEIQSKAKKTRRKRKNKKSKIKKGRIIKQHPENVRTSKVFSSRPLYTSTPIKQDLYEVEKIRNSSSDDLELSPVKESTCDIVNFDDFTVSDHPSMDPFYCSKIIEPGTALRYEYENGYQYTYKVVDEGRLELLTKRYYPYGGCVTLEEKKQLKAKLEEEKNISTLSLQKERKSIKSALKRKDTSKKLSSVRFDSFICRQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CE63</accession>
    <name>A0A0N5CE63_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="9">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CE63"/>
    <dbReference type="STRING" id="174720.A0A0N5CE63"/>
    <dbReference type="WBParaSite" id="SPAL_0001615400.1">
        <property type="protein sequence ID" value="SPAL_0001615400.1"/>
        <property type="gene ID" value="SPAL_0001615400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001615400.1"/>
        </source>
    </evidence>
    <sequence length="669" mass="78906" checksum="1F9FE2554A50E7F8" modified="2015-12-09" version="1">MSKKLSFTSMDKTTIILDKKMNILENSDKELQKKRNDGWYNVEDESLFPEIQLDKNIPIHYIVEALELRREYMERIGCFFPKTTERFLDNNYDNHSSNFIKKNISKDTTAFHPPEPDPDHWGINKSLPKYERTFTFKSEGGIIRILNENGYVKEFDKYYISKQKFLKDYDRMIQIIANGPLKSFCYRRLLYLKSKFQLYQLHNDQFEIHEQKSVLHRDFYNVRKVDTHIHATSSMNQKHLLRFIKKKFKKDRDSFVLEKDGKKLTMGDVFKNLDIEPYDLNVDMLDCHADKHTFHRFDSFNSKYNPIGETVLRNIFLKTNNYVGGKYFAELLKEVYKELEDSKYQHAEPRISVHGCRRDEWSNLASWAIKNDVWSQNAKLLIQIPRVYDFSRSCNLVKNFGQLLGNIFIPLFEVTNDPSVDPTLFRFLLQVTGFDCVDDESKHEYIQFDKFTSDPDEYIDSENPSYTFYMFYFYANISMLNAFRRYRGINTFSLRPHCGEAGAVNHLISGFLTSESIAHGLLLRKSAVLQYLFYLTQIGIAMSPLSNNLLFVPYDRNPFPEFFMKGLNVSLSTDDPLMFHFTKEPLMEEYSIAVQVWKLSPIDMCELARNSVYQSGFDDKIKIYWLGVNYKEEGVPGNDISRTNVPDSRIAFRHETLIEELYNIFKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF91</accession>
    <name>A0A0N5CF91_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF91"/>
    <dbReference type="STRING" id="174720.A0A0N5CF91"/>
    <dbReference type="WBParaSite" id="SPAL_0001653000.1">
        <property type="protein sequence ID" value="SPAL_0001653000.1"/>
        <property type="gene ID" value="SPAL_0001653000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057573">
        <property type="entry name" value="NOL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24419">
        <property type="entry name" value="Cupin_NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NOL9 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="7">
        <location>
            <begin position="193"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001653000.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="68974" checksum="BC5BEAA969D1CD96" modified="2015-12-09" version="1">MSETKDNIIFSKDKKSAILSIQKNHHIAIKGYTNVACLYGEVFIHGFYINSKNSSPHKTYPIASYSSSLLNTVIVNRGNQIEEEDINNIKQSLLPEFPDINENLSGYTKFTAIVYLVNAPEPTIKLMRHFFPELLSNFRQIKGTEIFNHVYLLDNECHAPTSVLYDLSTEKTILQQIEKEECKDEPFTIISIGSKNSGKSTINRFMANAFISQNQYTVLWLDLDIGQPEFTVSGFMSLIELKEPIFTPPPFHMKIDEGNILFVGKYEMDSLHRRYITILQDLVRKIQSTYFGKEKKCVLIVNTMGYIKDKGKDLLDEIIGILSPKLFVMCTDNNQFEYNNGNMNNRNTVRVYNKLDETVYKNPYVVKRSKMIDNGRDARKMRVIGYFSNIFKTFSFVPYSTNPARWPVYVVKMKNYFIFNEPDLPLFEECRLKESLEVTMVALCNFTDNNEKGFNKVPFGDSDLPTPIVICFKGLTMKLNYRLTNLDSFGVGIITHVDMINKTFSICTPLKRDVFENNVKVLARGRGLQIPPILLNCQVNDNYDGYRSLKTYSKEWVVYNQTTARHHESMIKSKFQRDNGQTKKIRTQEVITISSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH86</accession>
    <name>A0A0N5CH86_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH86"/>
    <dbReference type="STRING" id="174720.A0A0N5CH86"/>
    <dbReference type="WBParaSite" id="SPAL_0001720600.1">
        <property type="protein sequence ID" value="SPAL_0001720600.1"/>
        <property type="gene ID" value="SPAL_0001720600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001720600.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11736" checksum="CB12629B5ED55D5A" modified="2015-12-09" version="1">MVEIKIRKNYIPVDKYSDYNFVGRILGSRGLTANVLEHRSGCKIMIRGRRSMKDKSNEQNFIGIPNYQHLNELLNKDVVPASGNTDNLKKSQLVKLALNWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHX8</accession>
    <name>A0A0N5CHX8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHX8"/>
    <dbReference type="STRING" id="174720.A0A0N5CHX8"/>
    <dbReference type="WBParaSite" id="SPAL_0001744000.1">
        <property type="protein sequence ID" value="SPAL_0001744000.1"/>
        <property type="gene ID" value="SPAL_0001744000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001744000.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36909" checksum="649FA3787E58D100" modified="2015-12-09" version="1">MGNIIIGSTISISFTCLLRMFFKGKHFNENISAKDKIIIITGATSGIGKQLVRELNIREGKVYMFCRDEDKAFEARLSLVKYGCDPTRMIFIHCDLTNFLSIRKAVDEFKKDERIVDVLINNAAVMYYPKFELTVDQCEVTWQTNYLGHFVLTELLTPLLQKSVDGGRIINVSSGLERRCKEIDLEKINSPEYFGRMKAYDRSKLAQIMHAIEYTRRIRTIDPDTKITFNSCEPGIVNTHLFRHTIFQNKLINIISSPFRWFFLKTPNDGAQSPLYLALSQKVSSISGKHFVGFSEKNKINDIALDVNLCSELYDYSMQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CI24</accession>
    <name>A0A0N5CI24_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CI24"/>
    <dbReference type="WBParaSite" id="SPAL_0001748600.1">
        <property type="protein sequence ID" value="SPAL_0001748600.1"/>
        <property type="gene ID" value="SPAL_0001748600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001748600.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="84520" checksum="172C81FE217D6A89" modified="2015-12-09" version="1">MDPYNHNVGNPSMSNKALPYSICQTISATSNYLLPNYTNQLGQIPSLSSSVTPCSETMSGGYTYPYESSYYQQQLISNNIYNNQGNYPLNKTTQTLRSINYAIENSLNPLMNTYQQPITENCISNSRNFQTQQWMQNHYFDSQSYNVATPSCTPSMMSNMSHTSIANANPQINCQTNGIESGRMTEIKSIFKTESYPNSVISFTENLDPSQDQFTEDCRKNILNNLLDDDIEVRSKAYKIIKYLSIEKENQARPFIMDIMNTIGIDRTNSLSLERLLECLCHLTYNSKTIGCIINSILDNNLVFIDTLGKRIVKDQFNRYGYGYYALSILHAILSLSGDISKILTKYTRKPFIMNRIFEYFNKILTISSVNLYDQSYYFERKEIIWLIECLKHLILDNDNMKEYSLSKNGVEILLKILKGSEREYIHYHALSCINAFIQSGSIKYVIEFVRNNLVDIAFSIVTTSSLSEEELKRENKQNINTESSEKIKNIEEVFDNCLITFKNLTYHFQVEEIFKVGVDKLFKVDGSLQTLMNLFVYSTMDINKSRIIIILLRGVLFYKYDTERLPYLLDIIMKHIKIIIDVIFERSIHFNQSNDASRKNLKNLLQKVIYFIKCLCLEYGGVSSKIREILRTNKINLLKIIDNIKDVEIRSEVIQLAGVLLNKEDNIVDKWLNNLQTQSTIKDCSSSEDVNLREVTMNFLKLAQETRCSILVEENMDCDNGISISSIYADIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2W0</accession>
    <name>A0A0N5B2W0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2W0"/>
    <dbReference type="WBParaSite" id="SPAL_0000041275.1">
        <property type="protein sequence ID" value="SPAL_0000041275.1"/>
        <property type="gene ID" value="SPAL_0000041275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000041275.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24979" checksum="08486B22FEECB17F" modified="2015-12-09" version="1">MVNSSNVMVIEKVKENLKVIFEDDIEKKESCQDVVLNCPELIRILFEHLIMPVDKLNFRLTCRKFYESIKNKVHYEEESILTDKFHTSFTMLIKGIAFKFLRGSLKMYLIRPPNWDEINFNIISQKIQNNLGNVKKLFIEFDSFIKVEIFSQFNCFKSIKILEFGGDIQSHHLLLFNYSISLQPHTIIFSNFVNFLSINDTTFDKEWSFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B341</accession>
    <name>A0A0N5B341_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zonadhesin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B341"/>
    <dbReference type="WBParaSite" id="SPAL_0000049200.1">
        <property type="protein sequence ID" value="SPAL_0000049200.1"/>
        <property type="gene ID" value="SPAL_0000049200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000049200.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33603" checksum="317D27987FFABDD6" modified="2015-12-09" version="1">MNIFQTIYLYYLENSRHDNTNSLNFNFPQYIDDSNAIKRSLSSKVKTENDSKEEKRKNDDEVSIKLHCLRQKTRRPPTRRPTMRPIRRPLPLVRRTTRRPPPPRTPIRRTTRKMTTRRTITSKRNNPQRTQKPIVHRPKTAPPVIIRPKTAPTRPPTTTTRRTQSTTTTRTTQSTTTTRRTQSTTTTQTTQSTTTTQSSQPTTTTQVTQPTTTTQKTQSTSTTQITQPTTTTQKTQSTSTTQVTQPTTTSLQVIQPVTTVLPPITKNSNRRTSKLKKTSTKKSPTTTGDEYGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3S8</accession>
    <name>A0A0N5B3S8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3S8"/>
    <dbReference type="WBParaSite" id="SPAL_0000073075.1">
        <property type="protein sequence ID" value="SPAL_0000073075.1"/>
        <property type="gene ID" value="SPAL_0000073075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893716" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000073075.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17840" checksum="30C4AB08B9B6AC57" modified="2015-12-09" version="1">MKFYILFLTLINILLSQEPPPLPLKRHSYVKAGNSPVLYSKNHTHGNDVIPPQLPSKRFSYVIPNQNKVLRPQSMVNYSVKLYLARGMKFYECNRVTFSNQAQAEKYCAMLNKYELKKAEQNHRHHTSTIENRRKSLSRSNSDLTNKRNSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4F6</accession>
    <name>A0A0N5B4F6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4F6"/>
    <dbReference type="STRING" id="174720.A0A0N5B4F6"/>
    <dbReference type="WBParaSite" id="SPAL_0000095800.1">
        <property type="protein sequence ID" value="SPAL_0000095800.1"/>
        <property type="gene ID" value="SPAL_0000095800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001170">
        <property type="entry name" value="Ribosomal protein S6 kinase alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="125"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="385"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="503"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="509"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000095800.1"/>
        </source>
    </evidence>
    <sequence length="816" mass="92126" checksum="8E4F226998798C97" modified="2015-12-09" version="1">MVIEKQELDRQGTDGNFNFLYPSIAMTKKNIHSSLQSSSNHSDSGISNNNYSSSNLTLNLKDLTSTTFTTTTTNTNKNNDPDTTSNSCFDYEDNLVQEEVENVNETEINISDVRKQGEKATASHFELLKVLGQGSFGKVFLVRKIKGKNTGKLYAMKVLKKATLKVRDRVRTKMERDILAQINHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEFMFTEDDVKFYLAELVLALEHLHSLGIVYRDLKPENVLLDSDGHINVTDFGLCKESIYEDSKAYSFCGTVEYMSPEVVNRRGHTTVADWWSLGVLMYEMLTGHLPFQGENRRETMSQILNAKLTMPPLLSPEAQNLLRCLFKRNPTRRLGSGPDGVKNIKSHSFFATIDWEKLLKKEIDPPFKPAVVGMDETTYFDSEFTKKTPRDSPVHPPSAAAHELFRGFSFVSPSILESGNIKSSTSSPSDMYKHAISNNVNESLKGCLENLSGMKVCDDMAEKSFFDEYDVKEELGIGSYSIVKKCVHKTTKAEYAVKMIRKGKRDISEEIDILHRYSNGKYIGKLFGVYEDEGCVYLVLEYCKGGELLDKILSKKGFSEREAASIIYRLSTALVYLHNNQIAHRDLKPSNILFASEDMNPESIRIIDFGFAKQLRADNGLLMTPCYTAQFVAPEVLKKQGYDMSCDVWSLGVLMYSILSGEAPFSMDPKDGPETILEKVGEGIFSMSGGNWKNVTEIAKDLIKRMLHVDPSKRITAKQILLHPWISQRNLLPHIQLNYSSVPEKVKEALNTMFKAIENPSKPVPLRPVISSALAKRRQIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4F7</accession>
    <name>A0A0N5B4F7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PALP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4F7"/>
    <dbReference type="STRING" id="174720.A0A0N5B4F7"/>
    <dbReference type="WBParaSite" id="SPAL_0000095900.1">
        <property type="protein sequence ID" value="SPAL_0000095900.1"/>
        <property type="gene ID" value="SPAL_0000095900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000095900.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35936" checksum="523638CFF735FE5C" modified="2015-12-09" version="1">MSMEEITLQDILNANGRIKNDIIKTPIIKNNYINKLTGKNLFFKCENFQETGSFKVRGALNAVKKAIENGGDVQGFLTHSSGNHGTALAWAAHVVGKRCIVVVPQNTPQFKRKRIERYGASLIFADNTIKGREDTCEETRITTGFYVIQPFNAFEVMAGQGTLAIEIEEEVPNCEAVLVAVGGGGLVSGISTYFKEKNKNVKVFCVDVEGKNLQDSVLAKKRLWDDDGASLDTIADGIRVKVVGDKCFEQVVNNCEEEVLTVNDEEIIEAMKIIYEEMKIVVEPTGAVTFAGLLKYKDTILKDVKNITLIVCGGNVSSNDISKIFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4K0</accession>
    <name>A0A0N5B4K0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leptin receptor gene-related protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B4K0"/>
    <dbReference type="WBParaSite" id="SPAL_0000100100.1">
        <property type="protein sequence ID" value="SPAL_0000100100.1"/>
        <property type="gene ID" value="SPAL_0000100100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000100100.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13469" checksum="2C6871AEE79EA18A" modified="2015-12-09" version="1">XVAGIAFALCTGLTLLVLACAIPRLSSWWPMFVVVFYILSPIPINIAKSFGGDFDTGNPIIDFAIFLTTGIIISAFGLPAVLAHVGTIQFEAWIMTAFANVIIFSTIVSYFYYTEKDTMTFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4T8</accession>
    <name>A0A0N5B4T8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5B4T8"/>
    <dbReference type="WBParaSite" id="SPAL_0000108700.1">
        <property type="protein sequence ID" value="SPAL_0000108700.1"/>
        <property type="gene ID" value="SPAL_0000108700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1297"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="260"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000108700.1"/>
        </source>
    </evidence>
    <sequence length="1334" mass="153970" checksum="3968954C4168A326" modified="2015-12-09" version="1">MKTNLYKYCFSILLFFILQYIYLIDGTPSASSVSNWSIQLKNTLHKLIVDIGQPDKIIERYQKISESKIFDPRVELKKIKKEIEKYMGHRAKLAWQAKSSLQAKSLPQLNSTRVNDPQDSQFIRYMNAKLDSDGTVVYKDGAERVAIHINSTRRFQYHVNANFYGQKTSFEASAVHFPTPVYNREPELLMQVQWSDIDQFYQKNKERVKDLFFQSFCSESGFLRYFPASPWKFDNEPSRLDLFDCRNTEWFLASATMPKSIVIMLDLSGSMLGQRFEIAKQTVETILETLSDNDYFNIIPFSKTANLLGTCDDENLLLQATLRNKKILRSKLSAVVSEGKADYEVALAKAFSTILNLTSELTWKTKEEYEKELLLGNNGNVSLREKCFTLEDHVVCGDPAYFEHITNINTESKNKNIGCNNAIMLITDGAPGYYKEIFELYNKDRRVRFFSFLIGEEAVDFDQVKWMACINRGFMVHINNMADVHEKVQHYIKVMSRSVGYIASEIKEDDATWSGIQLERISNKFVTTVGYPVILNEDVMGVSSVSIPLTELNQFATPSMIGARSHFFMLDNNGYVVIHPQLTPFEPDTKKLKSGYNNMDLVEIEVLSQDKIDLDETHIFTCDNTETPTWSVLYAVENMKRVYPQVNKYYTECINNTEFIIGFAIGEGDEKRLERREKKMDYTKVDLSWFDSTKFIIHPEWRYCLLNDSDFDITPEEALKSYASEMRRSGKLPELCKSREYLVNQVLLDAQATKDLKEVWQQKWAEHLEDRINLVFLATPSGLIRYYDENVETFKYLSDIDNSTERENYPYKHFIRDHHKKSTEEEWYKRAVRMKGRIVIDINPLYQIPYDGPKETAYKMYENSTILAHAYKAIYLDGVVIGVLGIEFDYDYVVGTMDKIGCGPNTKNNWCFLLDEHGYVIYSSKKDTTFSAYLTPGSLDPRNKDNVLGKWFGKVNRVTEATMKKLTDPKYNYYSISKFVDYQAVCIRDKAVVAHASLLPISPLKNFISIITWFVRSIVKLAKTFNLPFILSMFEAAKANAYTPSFQKTENNSYACEKESPFFIANFDKKHDTYPSLNEKNTYDRPCTNHGNCAIKLYASWVQDTNLLLVSIVNTPESNCYDETQCAIQDEKDLQFEFKIKTDPGDLGVTTPPPTSTTENDGGTKPKKIDIIASNLNNILSAKTTPMPNLALSTPIDKKFFKCKKSPSKRRMKAIETCGAFNVSFFKEAQPCSGGFNVPVYGSNLIITMFSYWILILFYCFLYTNLLTKQTIFGSTYINIYIRITQPSKRKNFNKNAFNYHCLVALIGFSLFYYKQLELYFSFLIPKKTKFFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5G2</accession>
    <name>A0A0N5B5G2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5G2"/>
    <dbReference type="WBParaSite" id="SPAL_0000130400.1">
        <property type="protein sequence ID" value="SPAL_0000130400.1"/>
        <property type="gene ID" value="SPAL_0000130400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000130400.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10843" checksum="DFD6DA83BC7626B1" modified="2015-12-09" version="1">MKRLRLEIIFADPVSYDEDFQKRIRREKLPIYPVKVDQSDWIYEFWEKDVDEVIDRMEEMGGWLMTSSGEIVDFDFYIDYNYELEITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5I1</accession>
    <name>A0A0N5B5I1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Movement protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5I1"/>
    <dbReference type="WBParaSite" id="SPAL_0000132300.1">
        <property type="protein sequence ID" value="SPAL_0000132300.1"/>
        <property type="gene ID" value="SPAL_0000132300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000132300.1"/>
        </source>
    </evidence>
    <sequence length="36" mass="3848" checksum="0162B47A76E4F2B8" modified="2015-12-09" version="1">KIERDKIREDDIGGTPTPGTFASSGNSRFTHTTGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5Q6</accession>
    <name>A0A0N5B5Q6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unspecified product</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5Q6"/>
    <dbReference type="WBParaSite" id="SPAL_0000140200.1">
        <property type="protein sequence ID" value="SPAL_0000140200.1"/>
        <property type="gene ID" value="SPAL_0000140200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000140200.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12220" checksum="3F28B88E1BF1D919" modified="2015-12-09" version="1">MDRNNDTFLIVDKPDVKIEPLTNCQFKRYSNGDGYKLNAMWKSLTNPNDSIHNDDSFWNDIDLKKSFRSQLTRGYKILLSSLITCIICLCGLLLFLIILDFVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6R9</accession>
    <name>A0A0N5B6R9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6R9"/>
    <dbReference type="STRING" id="174720.A0A0N5B6R9"/>
    <dbReference type="WBParaSite" id="SPAL_0000175500.1">
        <property type="protein sequence ID" value="SPAL_0000175500.1"/>
        <property type="gene ID" value="SPAL_0000175500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="255"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000175500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42633" checksum="FACF90F3A2E23707" modified="2015-12-09" version="1">MKKDFLKNEDEEGESINGIGKETADCSIEGLSEMTKTCYITTDAEKDVRKKFCETLLASKTIKAVVSNNEFKNPKYKPKDLPATAFAKNVSLNRYNDVKCIVKKASKSSSIEDKGNFNDSDYIHANYVNVPNSDFKYICCQGPMENTLDDHWLMCWQENVKVIVMLCELEEDNCEKCHKYWPDLMTKKAYGGIVVSNEKEDFNKYPNVVIRTFRIQLGDKKRTIIQYHMKSWPDRLIPTGTPIICCMLREVQLVSGLNPIVVHCSAGIGRTGTFIGIHYVSEKFKVSQDGSINVMEVIREMREQRLQSVQSTIQFGYLHICLLQYFCEENIFELSDEVKKFIEKSVKLVHEYALRLAKKNKEKENEIKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7Z2</accession>
    <name>A0A0N5B7Z2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7Z2"/>
    <dbReference type="STRING" id="174720.A0A0N5B7Z2"/>
    <dbReference type="WBParaSite" id="SPAL_0000216600.1">
        <property type="protein sequence ID" value="SPAL_0000216600.1"/>
        <property type="gene ID" value="SPAL_0000216600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="182"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="368"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000216600.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="65286" checksum="4F53FED4B0D55F0F" modified="2015-12-09" version="1">MYHPTVHSDSEDVDILKSSSDESDTEGVKIKKRKISKNNEFNSGFTFDIGGPKVVNDDMNGLKNLLRNSRISTLQEKIDKERLKNKKSEAQLIKDLSEYKEDEDDLVQEMDEILDSVKIKEVKKKKKSTSNDYFDETKQKKLDESGNLKISSFHDMDLSKPLQKAVTNLGFTNPTPIQEACIPVALSGKDICACSSTGTGKTAAFMLPILERLLFKPVTKENDIRVLVLCPTRELAIQVFQVTKKLGEFSKVKICLLAGGLDVKKQESSVLEKPDILIATPGRLIDLVKRISEFTLKKIEVLVLDEADRMLEEAFADQMKELIHMCGKKRQTMLFSATMTEEIEDLIKMSLDKPVKLFINDNTVVASNLSQEFIRIREGQEDNREAIVAALVTRNFINHTIVFVPTKKECRRLHIILGLLGVKGGQLHGNMNQTQRVMALNDFKTGKIDVLVSTDLASRGLDIEGVTTVINLRMPKDIKIYVHRVGRTARAGKSGRSISLVGEDERKLLKSIIKSNKDGSLKQRNVSSIVIEAYKKRIDSLEGSVKRIDEMEKAEKEIEEASKKVKESEKKMTEEEVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B811</accession>
    <name>A0A0N5B811_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B811"/>
    <dbReference type="STRING" id="174720.A0A0N5B811"/>
    <dbReference type="WBParaSite" id="SPAL_0000218400.1">
        <property type="protein sequence ID" value="SPAL_0000218400.1"/>
        <property type="gene ID" value="SPAL_0000218400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="11">
        <location>
            <begin position="256"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000218400.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47676" checksum="BACC004E95581CFE" modified="2015-12-09" version="1">MALYTDPNWKPAVEYEELAIKGWNHGIVEINGENLAFKIEDKLAFEFPLNTVSNCTGQKNEATLEFHSNEDAPINLVEMRFHMPQDVNAEEEIDRVEEFKKAVMEYAGIVTETDLPLAYFSQLLCATPRGRYDVKVFPTHLSFHGKTYDYKINYRSVDRMFLLSHKDGRHVFFVLSINPPIRQGQTRYPYIVFEFSKEDIVEFDVNMSPELLEKTYNGKIASHHSGPVHEVFSKFLRILTNKKVTVTGTFVSKQGNQSIDCAYKQAAGFLFPLEKGFVYVHKPPMYIRFEDISSINFERSDLTTRTFDFEIDLKNGQTVTFNSIDKDENNHLIDYVRSKGLNVRNARKTQDIKGRNGGDDFDPYREALKKDAVSDDDEDESEDEDYDVEKDEKKLANLSGSSEGSASSESEEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8I7</accession>
    <name>A0A0N5B8I7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8I7"/>
    <dbReference type="STRING" id="174720.A0A0N5B8I7"/>
    <dbReference type="WBParaSite" id="SPAL_0000236000.1">
        <property type="protein sequence ID" value="SPAL_0000236000.1"/>
        <property type="gene ID" value="SPAL_0000236000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000236000.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="34105" checksum="EED0E5A98AD9AC27" modified="2015-12-09" version="1">MTIKDRSKEFNDLKVINNQRGSVIVMDEEDGLKLFFEFVERIREKIKELDEIINKLDIAKNDIICETYCNREIYTNVINLVKDFDKNVQIIRKELKSMEEQIKYDENYPNGVLPTFQKIRKIHLKHLVVRFQEIIVKYNHSQEEYKNCCKERISRTLSLEGYSVNEEQLDEMVENGLFNVYTNNINIGLQFIEDVQSRHKEIIKLEKSIVKLMNLFQDILFIVDSQGEVIDRIEENIELAEAKVFQARKYAILASRQKKRLLKAQMFCGSLCIFLILITALLLYSYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8T9</accession>
    <name>A0A0N5B8T9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8T9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8T9"/>
    <dbReference type="WBParaSite" id="SPAL_0000246200.1">
        <property type="protein sequence ID" value="SPAL_0000246200.1"/>
        <property type="gene ID" value="SPAL_0000246200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="381"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000246200.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="55795" checksum="F08DF8BA6CE71C54" modified="2015-12-09" version="1">MGASKRSVAKLKVPPNLKTAEDNDKKQKVKEMNKNNLGDKSTYTSMGKVKMPSREDGNKSRCDVRNNKSKMSMPIKAKSGIIPHDNVNIVTGKKPKAQSKNVKTAIFNSKMNKKEFLKNEDEEGEGIEDGVKEPKNVSIGLTVDMTKTVVISADAEKDVRRKFCENLIKLKSIKAIVASKEFKDPKYKPNDLPATVFAKNVNLNRYSDVKCIDKTRVKLKRNLVGFKVKKGNKSSSNDEKLIGPDNDYIHANYVKIPNSDFTYICCQGPLENTLDDHWLMCWQENVKVIVMLCELEEDDSEKCNKYWPDLMTKKAYGGIMVSNEKEDFNKYSNVVIRTFRVQLGEVKRTVIQYHMKSWPDRLIPTGTPIICCLLREVQLVSGLNPIVVHCSAGIGRTGTFIGIHYASEKFKVSQDGSINVMEVIREMREQRLQSVQSTIQFGYLHICLLQYFCEENVFEFTDEVKKFIEKSVETVHEYSIRLAKKNKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9U6</accession>
    <name>A0A0N5B9U6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9U6"/>
    <dbReference type="WBParaSite" id="SPAL_0000281600.1">
        <property type="protein sequence ID" value="SPAL_0000281600.1"/>
        <property type="gene ID" value="SPAL_0000281600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF42">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000281600.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36439" checksum="C7C2D23C65CBF695" modified="2015-12-09" version="1">MIAYNLILICIDLLLLFLSITVYLFLLWKLIRKDPDFPIKFYGILVINNTFEFIFIITEYFIVRLPFFNVLNEWYINMKTFPGMLYGLSVYLPCIIGFGHLTQVINRFVIIKFPLSFDKIFNKWLIGGLFVLQFSFPSVIMLWCWNETGVVSFVEDDSTTILELQNYKKQYNSIIFGICSIIVSCAACCFFGIWSFILVVKMRQGNNATQLRREINLFVFVSFEILAQILLIIAAVIQVVSGYLTYNPSVYNIALHLYPFCEDLLCLVNGLILLITCQTVRTRYIAFYKKLLLCNRFSSKKAKPAAQLSSNRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9Y5</accession>
    <name>A0A0N5B9Y5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9Y5"/>
    <dbReference type="STRING" id="174720.A0A0N5B9Y5"/>
    <dbReference type="WBParaSite" id="SPAL_0000285400.3">
        <property type="protein sequence ID" value="SPAL_0000285400.3"/>
        <property type="gene ID" value="SPAL_0000285400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="70"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="297"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000285400.3"/>
        </source>
    </evidence>
    <sequence length="621" mass="71177" checksum="83D255089BA90F0F" modified="2015-12-09" version="1">MNNLGSKKDNRNWGDYYFGGRKGNAKRSWALEVLHSLNQMIPTFNELFDKETFYMFAIFVVIVTVLKATIKHMLSNYDVICQAPTGSGKTLAFALPIFHLLQKQIKKNQIGEGVGAIVLLPTRELALQVSNVFKPFCEALNIPLSLLMRDKKLNENNFTKTSILIATAGKLKHFLQQQKEPKQLFKHVEILIIDEADRFADLEFKDSISALLAALPKQRRTSLFSATQAKDMEEFLKYGLRNPLRITIKGKVDNVKNSNNSEDNEDDVKKESDKIVGAPKELSNYYLTVSAEKKIITLVNFLKKYKKSKFLIFMSSSHCVDYYYSILRAEIPVSRAIFKCKGLSKNSKDGTITKFERSGPSILLTTDILARGIDIKGIDWVIQFNIPKKSSWFIHRAGRTARNGRKGNAIVFLTPEENNYVNYIHLHEKLKLEEFKFDDVSDEEAEEFRNKLIERHSHDRDALELVTRAYMSLVKALVSHDCQVVCKGKNMDLVGYANSYGLLRLPKLPELAKRDLSGFRRPNVKCSDVPYKDEKKEAERQKALEERAKETAKKYAEREARDAVKNNEPNKKVNKKLEAEKEIKRKRKAANQEWNELAQSQNVLKKLKKGKISKEEADELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBZ9</accession>
    <name>A0A0N5BBZ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBZ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000099800.1">
        <property type="protein sequence ID" value="SPAL_0000099800.1"/>
        <property type="gene ID" value="SPAL_0000099800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000354900.1">
        <property type="protein sequence ID" value="SPAL_0000354900.1"/>
        <property type="gene ID" value="SPAL_0000354900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000099800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000354900.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="19153" checksum="4ABB0D689F895449" modified="2015-12-09" version="1">MDPNEPLHDPMDHVERGIKELKECFNRDAVYMFEAVEECVNEIVVWQIVSQPNFNRIKEHSKQIRALKNNFQKKFELTVARWIWELQEEVGAEVIHPIEKIKNLFFNKQGITRQDFRNLVGMKFGQFLKKSEFVTFFEFVGESKIILKKIENEEDIFSNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC63</accession>
    <name>A0A0N5BC63_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">DNA topoisomerase</fullName>
            <ecNumber evidence="4 10">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4 10"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC63"/>
    <dbReference type="STRING" id="174720.A0A0N5BC63"/>
    <dbReference type="WBParaSite" id="SPAL_0000361100.1">
        <property type="protein sequence ID" value="SPAL_0000361100.1"/>
        <property type="gene ID" value="SPAL_0000361100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="12">
        <location>
            <begin position="169"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000361100.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="54626" checksum="3849836A7E1C0F17" modified="2015-12-09" version="1">MAVTVLMVAEKPTLAKTISGILSNNTAKRSKSHGKDPPQFHFTGMFKDQPANFIMTSTYGHIKGIDFEGRFSDWKIDEYQLFDCPLVKMNIDKSYSIDKYFSKIFNGCNYLVLWLDNDREGENICFEVMNACRPSFRKPNFEDYVYRARFSALTDMHIKQSMNNLTKPNRYESDSVDALHELDLRIGCSFTRFQTKYIKKQVPRSDMIKCLSFGPCQTPTLNFCVQRHKEIQSHSPKSYWRFKLTLRDDVDGVEFKPTWTGENCFDEELFKEKIKQLRKNKHAKVMEIERKTVHKNPPKALNTVELLKSCSKDLSISPNEIMEVAEKLYMQGYISYPRTETSVYPVDFDFNEILNKLKCDNEWFGVVNGILEKGVCFSSRGKDKGDHPPITPIKPSYNRLDGNDKKVHDFVIKNFLASVMKPCEYETYSIKLVLGDEPFTYYTRRIVDPGYTSFLKDEEVSEPFMDISQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD58</accession>
    <name>A0A0N5BD58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utp12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD58"/>
    <dbReference type="STRING" id="174720.A0A0N5BD58"/>
    <dbReference type="WBParaSite" id="SPAL_0000394800.1">
        <property type="protein sequence ID" value="SPAL_0000394800.1"/>
        <property type="gene ID" value="SPAL_0000394800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000394800.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39225" checksum="6DA2A02891B2044C" modified="2015-12-09" version="1">MVRTRSTKYTEQEEGFIPNGKQNGSLGIDNTYEKVNGKSPIKNGKKPKKNGTTELTMRELKSLDKKENIKVDQNGDLSSEDSVSSPLQLSAAASTSDSGSVVKEPTKKPLITDAANALATDSTNALSYAVSLTQSLLSSDSKKIDDILTGSISQREIKDTVKDLPTIHVIRLLKYIEEKLRGSTGGHVELLIRWSGIVISTHMSYLMTVSDLEKQLGSFFSWIKSRVSHMEALFILNGKLRLLCEQIDKRCNVVSYADQKPSMVFHPDDESDDELEKISALEKEVFDAANEDDEWWKEDEEIQEKLNVKEVSAKKKKGKKRHAEEEDSDEDMEISNQNMEVDDDDSENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDD6</accession>
    <name>A0A0N5BDD6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDD6"/>
    <dbReference type="STRING" id="174720.A0A0N5BDD6"/>
    <dbReference type="WBParaSite" id="SPAL_0000402200.1">
        <property type="protein sequence ID" value="SPAL_0000402200.1"/>
        <property type="gene ID" value="SPAL_0000402200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894397" description="acid phosphatase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000402200.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14696" checksum="01FC8B75CB4BCB2D" modified="2015-12-09" version="1">VKMKFLTSLFVTAFLIAGFFPLTYAQGNSQLIFIQSIWRHGDRSPTSSYPGDLYDESAWPQGFGQLSTLGMQEHILLGKKIKNRYYDQLKFVNKTYHNYHIYVRSTDVNRTIISAISNFIGFYYNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BF61</accession>
    <name>A0A0N5BF61_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BF61"/>
    <dbReference type="STRING" id="174720.A0A0N5BF61"/>
    <dbReference type="WBParaSite" id="SPAL_0000462900.1">
        <property type="protein sequence ID" value="SPAL_0000462900.1"/>
        <property type="gene ID" value="SPAL_0000462900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000462900.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53739" checksum="0803C8574C248A59" modified="2015-12-09" version="1">MTEVHEHVSNSEMELIPEMKGFCSSVVFIPRSVVDEKPIIVKLSASEMKNLVLNKNSLEESGDDSDNEDDKKDEEMDCGNNDNENAMKGGDTIGDEDEKAAEKYKMNEYDDAAAPLLISGISKFKEDDPYLKNPEEEDPEDLEDLEVRENENIVAYVINDLDDSEVVYTNFNHVTFHNYVRTSNFLHKCPLVIKYVHPESDAKEGNLTLVAIGFYEPIIELWDVNMINSAGPVITLGKELSKKQRKSKENFNSTHVDAVTTLSWNQNMPHILASGSIDKRVILWDITSESVGTLYDFFKEEIQFVLWHPIEVGILLVATATNNIYAINCSTDMTGEEAVNFKIDDDHTLESLDWDRQNPFIFYASSTQGFIYTFDSRKKGKYQHVTKSHESSTNVLLCSRKIEGMVLSAGEGNVIIWKADSNGSLTKIYEVKSLVGTIFSADFCPENPNVVVFAGNEGERLQFCDLSTFDEIVKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFI3</accession>
    <name>A0A0N5BFI3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel subfamily K member 18</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFI3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFI3"/>
    <dbReference type="WBParaSite" id="SPAL_0000474900.1">
        <property type="protein sequence ID" value="SPAL_0000474900.1"/>
        <property type="gene ID" value="SPAL_0000474900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="438"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="548"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000474900.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="81848" checksum="3B47C1CFA4B1B1BC" modified="2015-12-09" version="1">MSEIDDNLQKYRPPISSSHFGLTKQLVLKIALPHITIFLITLTYTILGAIILTKLNKWENTVENIANDIILKQKALLVSLTDNNNFNRERKNKDTNNEHHFFHLFFTGLEEVFQKSQDNAREVAKNVKNLKLQSHNTSFESFTMNLFFTSTTLFSIGYGFNSPYTIGTRIFCLIYITIGCPLYLITTADLAKFLSEFLYFAYMELIKLKANIALNFKFFRKKKRNRASHSKALDRFNRRRSQGSIQLGKLIIAGGEDEIAEFLWTHLEDAQFVEVPFSLLYFTLIVYISIVSYIISKYEDWSLLDSYYFVVISVLTVGFGEVIPKNEEHILLIIMLLVFGLIIMTTCVDLIGAYYLEKLHYIGRKRYTNNSSDEDPLDWLKHVQQKRIEMLKREAMRKLFETITALHHLQFFTNTSGNIILNNKNDNESMQLEPDYTPPAPLTISTLNPTTDSITVTWVPPVFTDEDRKKFKNKKYWYTLSVKNRTPQRRKYLNHFTVIDFINNATCSYEVTGLKSFTLYEFSIRTSTRYGTTSNPVRCQEYTEPCTVPTLLRAEYVGSDSITISWRQPKKNFNQLKNGLESYIVQYQISPDDPTIPFNFANWRRIKVGDVKSYTLIDLTPNTKYSIRVFCENNIGFTCVSKTITVKTRAWWFDEEMLIPTTPLIKQFLTGESRRGSKRNSHIDNEDIGEEDAMGKVFNTLSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFU3</accession>
    <name>A0A0N5BFU3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFU3"/>
    <dbReference type="STRING" id="174720.A0A0N5BFU3"/>
    <dbReference type="WBParaSite" id="SPAL_0000485500.1">
        <property type="protein sequence ID" value="SPAL_0000485500.1"/>
        <property type="gene ID" value="SPAL_0000485500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="224"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000485500.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="70759" checksum="D6DA4C705D0FA989" modified="2015-12-09" version="1">MKSSIMKLKFNRKEDEEKKRVQSEYKSKIIKPKEKKKTNIKSSPNQKSAETQRPAGLSKAPQVKEKYPSSNISQDQLKRTLTLLKKCGTCNEGNISQDYYKSLLISYLELITRCFEENIFPVDASSVITLPIFSDICHKVAEILSSEPTLLTINSEVPKETFLVLSDLHGCFEVLMFNFYHYHCLPKKKIIILGDYVDKGPDDAFICLFLFLCKIVWPDKLFLLKGNHEIRDMNRQKDFPDNCEHLLGDKSTFYMFNFVFERMPIAAIWNNNVYLAHGGISQWMTCREDIVNIKRPLKLNRTIKSRLLITDILWSDPYRKCYKTKEDFNKFFAVSKRGCGFAYSQEGLEAIMKCLNVNMIVRGHQTSKEGFVEEYKNRCYTIHSKPSSRENAFGSSCLLTLDDNGNVLLRPLKYKLPMDRSTFLSALGKLKSLWKSSKFSEFPFKKSCQYCGDKDNYVNELACMERILVTHAQLTMWLTSRKIQMMIELEFGKKVGKKWKNPEKLLSRFPVYFDFCISPLIGQSVRMNNVIEKKERDLAITILKKMEKVEDKNILIGDPNLTIDNLAFLRLNAVEGNKRKRFEYTSDDEYRTSGSDMSSGENDDSEDGDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGS6</accession>
    <name>A0A0N5BGS6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGS6"/>
    <dbReference type="WBParaSite" id="SPAL_0000517600.1">
        <property type="protein sequence ID" value="SPAL_0000517600.1"/>
        <property type="gene ID" value="SPAL_0000517600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000517600.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40640" checksum="9A2CE3CD9DECAC66" modified="2015-12-09" version="1">MDLAILSASFLQGSKNVQHQHDLWIAGILLASKYKEIFQNWKFGDLTYKKVSTELLLKLQSTHYFERILTFSDISPPGSYYDKLKFLQHAAETLNLRTSNCDLIIQAFIKTIPKYLYNTCKVPSTMSIEDFEAFAKDLDSKTSFSSNLNLSTIIDNPITHSTPKNQPKAIYSEQHGNCLSNNQASNQSTGLSPSQSIKMGSYTVSNISTEIPIISASTNVQIQPIVRTSFNLTIIDADKNLYFILERMKADENDILIGLVIFNKNSFYGYAGVILHKKKYKAITRTTKSNSEGEFPDNLGVLTQYGIKAISSLKTELPKISTSIIYLDPILRLPLLEIAEKKATEVIEGLVKGDKRISEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHK5</accession>
    <name>A0A0N5BHK5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHK5"/>
    <dbReference type="STRING" id="174720.A0A0N5BHK5"/>
    <dbReference type="WBParaSite" id="SPAL_0000544300.1">
        <property type="protein sequence ID" value="SPAL_0000544300.1"/>
        <property type="gene ID" value="SPAL_0000544300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000544300.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45003" checksum="33C33B5D5A395EE5" modified="2015-12-09" version="1">MNFLFSIVAIGNIVGTLTVQYLFLNIGAKNTFCIFLGISLISTGLTPIALRINYFFTLLIRFIQGISWAVSLPGMGAMTFSWAPLPESSIYLAILKTSAQVAPLITMYLSSRLCSNNFGSSSIFYVHSLISLCIFIIYYVFYNDHPKDSKYVSTEEAKYIKHKKEGSERRGHSKEPVPYKKVFLNPTLTLGNITYFIYFLNMHLWMQYAAIYMNLVLNYDVATTGIITSFPYSFGILVKVLYGYLSDKERFCSLSIVLRILQSTSQITTGITFIILGLFATQYRFLDVILYSVQIILGASCSVAIFKSCLLVSQQHFHFVMSIASIGNSIALLIVPSLVSLIMPNFEVEGWKALFSIIGVLTVVSNIGFLIVMKTEPEEWTKTNFTDNKNKETNLNNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHN0</accession>
    <name>A0A0N5BHN0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHN0"/>
    <dbReference type="STRING" id="174720.A0A0N5BHN0"/>
    <dbReference type="WBParaSite" id="SPAL_0000546700.1">
        <property type="protein sequence ID" value="SPAL_0000546700.1"/>
        <property type="gene ID" value="SPAL_0000546700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF20">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000546700.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36873" checksum="CA1CD31CE1CA670C" modified="2015-12-09" version="1">MENNTNNFQAYGSSMATSSFNFNVFIKKTTVALRILAVILSIVIWYLISSGAWYRLGTGHLICLYERSSTTCSFGSFMGSLALIIALIFLLIEAKYEQFTCVGTRKRIVLTDLITSLAIAFLFIVTTFTLWSKYSSLAIAFLFIVTTFTLWSKYSSLELDENYNGRSAKFAVLFSFLSVIVWAAIAFYAFRQWQASVQEHFDGTQFHGAPQSDVIMTSDYGYGGDSTGIGIDTTKINNITMSYQQSQPGQLNNIHNPHHQMGMNMPVNQQQSQGYGPPMSQPTQLGYGQIPSNQQFQPQMISTQSATYSMPQHQQTHGGLDGYTSNPFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI33</accession>
    <name>A0A0N5BI33_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Solute carrier family 12 member 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI33"/>
    <dbReference type="STRING" id="174720.A0A0N5BI33"/>
    <dbReference type="WBParaSite" id="SPAL_0000561700.1">
        <property type="protein sequence ID" value="SPAL_0000561700.1"/>
        <property type="gene ID" value="SPAL_0000561700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="134"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="419"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="729"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="860"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="1039"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000561700.1"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123340" checksum="2A93CCFDD7F5E692" modified="2015-12-09" version="1">MPQVDSTGELPSNVSSTDGAPVTGGRFQVSTVDHTPKNSTAVICGDSKNTNNTVILLQDKDNGENVPLCGKNDDLALYEDEYNTQGQKIGHMLRSLSLYNAVLPGSQKEDDVESTGAIKHSATVAAKMGTIIGVYLPCLQNIFGVLFFIRLSWIVGNAGIFGAFFVVLICCSVTFLTSISLSAIATNGVVPSGGPYYMISRNLGPELGGAIGFLFYLGTTVAGSMYVTGAVEIFLLYLIPEAKIFDDMYNNFRILGTLLLIIIGLIVLAGVKVVNKFALPCVLVVICCIFCTFIGGFVKSNGHQDLKYCMVGDRVVNLVKITEKLGKTPLCSPEGLKEAFCPANKSEGCDAYFEVMYSSGTNSFNNQSSIREELAIPGLFSGVFFKNFWPKYQKVGDVITRDATRGNSGTSAEKSPYVFADVTTGFMMLIGVFFPSATGIMAGSNRSGNLKDASKSIPLGTLGAQLSTSFVYLSGVLLIGGSVSDMFLRDKFGASAMGKLTIAELAVPHRLFILIGCFLSTVGAGMQSLTGAPRLLQAIAADDVIPFLRKFQYTDKRGEPLLAIVLTLIICECGILIAVIENITALITQFFLMCYLGINAACALQSIMKAPGWRPSFRYFHWTLSSIGAALCIAVMFISAWYFALFAIFIGAAIYKYIEYAGAEKEWGDGLKGLALSGARFALLNLEAKSIIHTKNWRPQLLVLFPSSGISAGAQPKTDDDKIETSDCRKGLLSFVSQLKAGKGLTMVAECIQGDFAKNYTLAETQKEIIHNLMKQHKIKGFNDVVVSKDYMEGISSLIQTAGLGGLRHNTIVVQWPTHWSDPSNLDDSANFVNTLRHASAGKCAVLVPKNVHLFPSSSERVHGFIDVWWVVHDGGLLLLLSFLLRKNKVWKNTKIRLFTVANVDDNTVQMKKDLEKFLYHLRIDAQICVVEMPESDISEYVYERTLKMEERHKMIRNLQIKEKRVDIQSTMDDVVRERKMSRVVTDDDIVSKINIAPKHNIRGVRFSENDEICNKEEDVKKVTIELETSSRESPSRTNEEWSSKIIKMKNYNVRKMHNALNLNQFMKAESSDAQLIIVNLPGLPELGLDTFYMEFIEALTEGLERILLVRGSGTEVITIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI58</accession>
    <name>A0A0N5BI58_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI58"/>
    <dbReference type="WBParaSite" id="SPAL_0000564200.1">
        <property type="protein sequence ID" value="SPAL_0000564200.1"/>
        <property type="gene ID" value="SPAL_0000564200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000564200.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25503" checksum="2FBE6E7EDFD7C63D" modified="2015-12-09" version="1">MDKLELNLLSLPDNFKLKIFKELDWKTLKNLKLVCRDFCFIIEKNIQCLDKPKSCLEIFYNQYRPFRVGYDLKGSENTWTFQTSKVVEFSNDCEYENFLKNKDFTRINHLFIENVANEGFIRLYNISCPSENFSTLDFSASLPNAIPSLEYLFIKIFITKGFRIPYNSNLLREQSLRKLGLYKENESSLVIKKIIMDILTNNPMLDYVDTSNVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI93</accession>
    <name>A0A0N5BI93_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI93"/>
    <dbReference type="STRING" id="174720.A0A0N5BI93"/>
    <dbReference type="WBParaSite" id="SPAL_0000567700.1">
        <property type="protein sequence ID" value="SPAL_0000567700.1"/>
        <property type="gene ID" value="SPAL_0000567700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000567700.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14223" checksum="756F0F3FF84D8229" modified="2015-12-09" version="1">MARTLKKGQVLSVIGDQDTVVGFLLGGIGEINNNREENYFIVEKNTTTLEIEEAFNRFVKRKDIAIIIINQKVADLIRQTIDHYKDSIPAIVEVPSKDSPYDISKDSFLNRARNIFQVENFMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIB5</accession>
    <name>A0A0N5BIB5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIB5"/>
    <dbReference type="STRING" id="174720.A0A0N5BIB5"/>
    <dbReference type="WBParaSite" id="SPAL_0000569900.1">
        <property type="protein sequence ID" value="SPAL_0000569900.1"/>
        <property type="gene ID" value="SPAL_0000569900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000569900.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55333" checksum="B2DA9A87A3886FB3" modified="2015-12-09" version="1">MLAKYDSNEGKLSFLDLQLKLNTLEDGKKVAVEIERCQKLITLELRGNSLGPGAVDPIAEALKKHKELKRILWSDLFTGRLKTEIPAILEKMLDGITASGAMLKEIDLSDNALGPVGVEGIKKFLASESAMDLEIVKLYNNGLGIGGKTVANCFVQCLKKAILKGKWFNLKVFIAGRNRLENTCAIAFAHAFKMIGTLEDIQIIQNGIWADGIRALADCFRFNPNLRIIDLSDNTCTHRGAVALANVVPMLKKLEKLVLGDCLCRDRGSLKIFRAIAKGQLKNLKEIDVSGSEITPKGAIEINKICKDHLKGVVVKLHCNNFSSEFGKLTNALKSIDLGDEDDDQGSDVEEDELWNSCVNGTEDLPIHIIFDFIKSPNSHSLGRVLKRRDDVIDELEDDMRVNLNPYTTARFIAATTTAVIPNSKEEKLASEMLVEILKRGRQIMRSNLPVLMQLSNNLISFSCLVKSEIQEKVPINFDILKNLTGDQVPEFTKCISAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIV6</accession>
    <name>A0A0N5BIV6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH_48 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIV6"/>
    <dbReference type="STRING" id="174720.A0A0N5BIV6"/>
    <dbReference type="WBParaSite" id="SPAL_0000588600.1">
        <property type="protein sequence ID" value="SPAL_0000588600.1"/>
        <property type="gene ID" value="SPAL_0000588600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000588600.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15542" checksum="937DD643357148D0" modified="2015-12-09" version="1">MLSKRDIRAIMLYEFKRDLVSVPTVQRWFRKFKKGSEDLENEERERPETVIDNDELREAVEANPRATVRRKKLDKWVPHELNDYQKMCRFEFCFSLILRNKNDPFLSRLITCDEKWILYDNRKRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKC8</accession>
    <name>A0A0N5BKC8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKC8"/>
    <dbReference type="WBParaSite" id="SPAL_0000638700.1">
        <property type="protein sequence ID" value="SPAL_0000638700.1"/>
        <property type="gene ID" value="SPAL_0000638700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000638700.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17811" checksum="3BF2903424846FEF" modified="2015-12-09" version="1">MSFPNQGMMSTMTMQNPSLINFDFNCKCVAKVNSAVNSPAPIDANAQAQQQIQQLQEQIKRLQETVRKTQQGSTPFETFANTLSLAEGLDCSCSGTQSGGGINQMGVPTYTGTPNQFINPSQLNQLTGIVQPSLQGGISRGGQLPIATRYSPVSEYGMRNNPFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKP8</accession>
    <name>A0A0N5BKP8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKP8"/>
    <dbReference type="STRING" id="174720.A0A0N5BKP8"/>
    <dbReference type="WBParaSite" id="SPAL_0000650400.1">
        <property type="protein sequence ID" value="SPAL_0000650400.1"/>
        <property type="gene ID" value="SPAL_0000650400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF23">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000650400.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44750" checksum="C099F36065A9A2A0" modified="2015-12-09" version="1">MAAVGEGILADKWNACSIQPHKAYQDDELTIDLVWWTNAVCLPTIAIIGITCNLINIFVLTYNPSSKRIPSKKLLLILAICDIFFLFFAVLEVSPMSIRSFLSSPIINEIYTKLALYIRTCASTFYKSSVLLVVVFNIERYISVCYPLRSHRLCSQKVINSTIIICIFFSFICSLHWPLAYQVTDCYDFHDNHEYFVISMTENPFWITYYRIMDYFSLFAFNVFPIVILFYLNFKLIMTLRKVIHKDLSLQRQITSSNQQTTQLINNQETNFNQRQNANKILFAVVAMLFICVAPQAPARLLYEILGHYHPTAIIYTCISQQLVFLNASLNFCLYCLVSRRYRSLLKESFRILLIPHKDFFTSSAVTFQLKTRSSSVHAQSSDEPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKV8</accession>
    <name>A0A0N5BKV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000656275.1">
        <property type="protein sequence ID" value="SPAL_0000656275.1"/>
        <property type="gene ID" value="SPAL_0000656275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894431" evidence="2">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000656275.1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6300" checksum="21B45D82647013E0" modified="2015-12-09" version="1">LMTFGLFYAVLFLCSPLRDLLLFKSIKESSYNNGSSNNSKNERLRTQQTKTPTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BL06</accession>
    <name>A0A0N5BL06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CNNM transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BL06"/>
    <dbReference type="STRING" id="174720.A0A0N5BL06"/>
    <dbReference type="WBParaSite" id="SPAL_0000660900.1">
        <property type="protein sequence ID" value="SPAL_0000660900.1"/>
        <property type="gene ID" value="SPAL_0000660900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905941">
        <property type="term" value="P:positive regulation of gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040026">
        <property type="term" value="P:positive regulation of vulval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032026">
        <property type="term" value="P:response to magnesium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894535" evidence="11">
        <location>
            <begin position="20"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="189"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000660900.1"/>
        </source>
    </evidence>
    <sequence length="791" mass="90498" checksum="ECE3BE6E140C3ABB" modified="2015-12-09" version="1">MKSFLILWVIFILSIFCYSKDDNVNSTAIIQGSHSTNRTFVKNDTEIVDPYAYEWESDKVVPVVCGMRAESVVRKGHVAGFLKSGVSVVEANVPIKLSVFGRWLERVEMISFTIDNCYHLLNNISHTEFLFQSEMRIEFITKFEKIAESKTYRMCISEKDFGQDGYEDMAFMIDEQRTWISTDVVASEYLLPLHIQILLICLLFVLSALFSGLNLGLMALSPQELTLLKKSGSEKEKEYATIILPVRQAGNYLLCTILIMNVIVNSAISILFEDITSGYIAFIVSSIGIVVFGEIFPQSLCIKKGLAVGAHTIWLTRFFMFLTFPLSFPIGKTLDWLLGEDIVVYDKNQVLHLMKLTPSWETGNTELAADLKIAVGAMEISDKTVKDIMTNIEDVFMLSENTILNPTTITEILKKGYSRIPVYSADNNKKITSLLFVKDLALVDPEDKFTVKTICQYYQHHVRFVSENTGLQEMLDEFKKGEYHLAFVTTTINQEMENFVEPIKQFDRTSFEEEYGPCDWESDQENLSMIDFKVFEEFEEEIVVIGIVTLEDILEEILQAEIVDESDVILDNVYKRKRKIDKANNCYKMVEYDEICKNVSNSLTLACSQFLGTRSFIFRDAYLDINAFHRIISSNVRIVNFHKAPLEEISSLESEICMCIIKERVPCDKMILILEGSCTVSFSGTQLEFTVGPFEFFGCSMVKILEECISTNNTEKLTAKNIINLRYIPDFSLKVTHYCRYLQLTPLNYANVYRITKAIRMGREINSKKLSIHSTDSVNFEKRLSFKHSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM40</accession>
    <name>A0A0N5BM40_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM40"/>
    <dbReference type="WBParaSite" id="SPAL_0000698325.1">
        <property type="protein sequence ID" value="SPAL_0000698325.1"/>
        <property type="gene ID" value="SPAL_0000698325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000698325.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13267" checksum="7FD6F5DCD2B8A398" modified="2015-12-09" version="1">MWMYPEEKTVIKVGNTEIPVHRVIFCHQSPVFYNIFSSTSKKSQESVFEIKNFRFEVAKQWWEFDTDDASDIRHMASEASVPVLASEMLPIAAEYRLDRSKVIAEKYLCADLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMM7</accession>
    <name>A0A0N5BMM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000716600.1">
        <property type="protein sequence ID" value="SPAL_0000716600.1"/>
        <property type="gene ID" value="SPAL_0000716600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000716600.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15335" checksum="6B48609E6F8584FF" modified="2015-12-09" version="1">MGHKKSISALFSYRNGSKHPLTESESRKASICTIYNGRNCLTPCYEYPPYYYSPPFQSIGAIEKGGSSSSSNSSSNASTPSSTDMKEIKEKSSGTWKVLIFILFVTLFLGITVYLERLKIEHFFKNQFGKLHFYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN11</accession>
    <name>A0A0N5BN11_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN11"/>
    <dbReference type="STRING" id="174720.A0A0N5BN11"/>
    <dbReference type="WBParaSite" id="SPAL_0000729200.1">
        <property type="protein sequence ID" value="SPAL_0000729200.1"/>
        <property type="gene ID" value="SPAL_0000729200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000729200.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9153" checksum="18E679D9FFB15B3B" modified="2015-12-09" version="1">MQNDKGELVELYVPRKCSTSSRLIAPNDYASIQIDIVDVDPATGHLIQGKVHRYAICGEIRRMGESDDCLLRLAQRDGIVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN82</accession>
    <name>A0A0N5BN82_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAP1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC85 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN82"/>
    <dbReference type="STRING" id="174720.A0A0N5BN82"/>
    <dbReference type="WBParaSite" id="SPAL_0000736100.1">
        <property type="protein sequence ID" value="SPAL_0000736100.1"/>
        <property type="gene ID" value="SPAL_0000736100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019359">
        <property type="entry name" value="CCDC85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546:SF15">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546">
        <property type="entry name" value="RE60986P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10226">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000736100.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="68088" checksum="24303E99138D618F" modified="2015-12-09" version="1">MSSTASTTSSNGYTSPLPSYLSSKSSKESIVNMNKLYQRLNILEYENQKLMESHEMLVSEVNRRSEMHIMEVSKLHRRINETEAVNQELKALCSMYENEAKKARVVVKENDKIRKYFNEFIKQELRIFADKTRELSINNEQLLIENKELKRLCLYLDEQRFDIINISKKHTCSNCQKVQEDIFECSDNITSNDKNEKENRIEMLTKEMQTSLCLMKDNDEDSAIITTSSNDSTCNENTKNNELLSYIYYLENRINNLEMGVHKPFSQMSSEFESNDEDNDLIRVSPLLMKKKNQLTKDLSNGSEIKILSDVCVSDVEMPSSNKLFNNINVNDTGNCINIDKEGNHEHDCIVYGGCHNFNECISNNFVRFLSKIDEDEEISNKSNVKNSLSDILTDLSSSQSPNSFTFEIPPPMADVSESIGRLSFCSSSNNSLNSIINTPNNINLIHNSYHPTNECYYEEIRVDNKLSSPIYTPISKIAKNINENSENGSRTSLGYRRQPSSNRRSVSMNNGVRRNIIDNEVSKLPPIRLRTGHLQNNTTSPTYYIPSEEDKRILQRACQLQFNQKLNKKENQKGTKILVDQKSGNIKAELTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNI8</accession>
    <name>A0A0N5BNI8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Laminin subunit beta-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BNI8"/>
    <dbReference type="WBParaSite" id="SPAL_0000746700.1">
        <property type="protein sequence ID" value="SPAL_0000746700.1"/>
        <property type="gene ID" value="SPAL_0000746700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043256">
        <property type="term" value="C:laminin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070831">
        <property type="term" value="P:basement membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000065">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000010">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000135">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000001">
        <property type="entry name" value="Laminin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000224">
        <property type="entry name" value="Usherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF375">
        <property type="entry name" value="LAMININ SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21199">
        <property type="entry name" value="LAMININ_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894604" evidence="16">
        <location>
            <begin position="25"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="19">
        <location>
            <begin position="29"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="404"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="464"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type B" evidence="18">
        <location>
            <begin position="554"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="779"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="827"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="874"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="985"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1037"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1643"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1742"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000746700.1"/>
        </source>
    </evidence>
    <sequence length="1796" mass="204187" checksum="7E24750E1A1E0A41" modified="2015-12-09" version="1">MREKFYLLLLIFSIISIIFIICEEEDLCNGQSCYPATGNLLIGRKKQLSVTSTCGLKNPQRYCIVSNLQGNSSCYYCDSRLPYSRRNPNSHGIENVIKNRDERRISRWWQAENGVQNVSIQLDLEAEFHFTHLIMTFKNFRPAAMLIERSNDYGKTWDIYRYFAYDCQSSFPGVKESLPKNHGDVICTDKYSHVSPSTGGELIYKVINPQIRTVNPYAEEVAKLLRITNLRINFTKLHTLGDDLLDNRNDVKEKYYYALYELIVRGSCSCYGHAQKCIPMSYDDSQLQNYEYDYQVQDMVYGKCHCTHNTKGLNCEKCEDFYNDLPWRPAFGKETNACKRCECNNHAVSCHFDQSVYENSNRTSGGVCDDCQHNTMGKNCEECKPYYYRDITLSHSSPYTCKECNCNKIGSLFNGICESEHDIERNLIAGKCYCKKYVDGDRCDRCKDGYWNLNDFNEDGCEECTCNTLGTINNEGCNKLTGECTCKRFVDGAKCDKCIENYYGLSEDLDGCKECDCDIGGSLSPQCDTITGQCLCKEHFGGRRCEVPEDSFYCPNIDYYTFEAEKGTRTGKESTIEYGGEIPKSSYQKWSGMGYLRVKEGSEINFDIGRVHKTLLYNIIVRYDSETNMIGWENVEVILSRPNIINSTNINSPCKNYNMDNDFMITRLRGRQIYEEINPTICLEEGVDYQLKIIFGERRTNYPDRSASILIDSIILIPQLNQLDIFNNPINGIYHLQQYNLNYCRHLLLLLTPFDDIPSICHKYTCSIAASMIGKALQCDCDKTGSISNICNGNGGQCLCKKNVIGRRCDECSEGTYGFSPNGCSLCDCDSIGSLDNRCDKETGQCLCNINEITGRQCDECYDGSWNFPNCQLCSCNSHSNVCDKKNGTCLSCENNTYGRYCERCRDGYYGDPRIEVNIPCKACMCPGNPDSGNYNANSCSFDYVSGGTNALCHCKEGYIGSTCDECDKNYWGNPKDFGGLCEKCECNGNVDPTVEGNCDKETGECIKCLYHTTGKNCELCENGYFGDGINRNCTHCQCNVYGSKNNTREICDQKTGKCSCLPNVVGEKCDECAENHYNLHSGNGCSECNCDPNGVILNYDGTPKMDCNQYTGQCHCKEGRGGKKCSECTDFFWGNPLTDQCIECNCNRLGSSNAQCNREDGTCQCKAGYGNITCDTCGYGYTGAFPYCDSCGECFKNWDTILKDLSNEMDNLMERENNVEELGLSSVYDPQFNTIENKLTEIGNVLRRNNITNDEMSKINIGKILFYEKSQKLRQRVNGVRYLVENMNKEKDSLDEYIDVIKEKLDLLSMDIDDIVRKSELLKEQNLEYAFNSTLESEKKSLEAQKSVEESFRLLNHVERNNYDLIELLNNHRDDFEKLYLENNNALRNITHEYSLLRRTSPNLNKMVCGGTTDSLDCDVLCGGPTSICPFCGGEACKNGLVPKVEEALVLSKEAMEKGKLLEDKLYNELSKIRSIENDIRKAHEKAFNAFNIISKTENNWYESGVEIEDTIEEIDNFLIKDKKTQENITNIINEINNLKINVDRNAAYKLSVDLYYAMLKIPNATGIVDEAIKKKAHALDILNKAKNSLMLSTNVSESSEAARRYIKNATLHLKNVDKIMGYFFNNITKSRMNFDEGVFYGRDAENLLKHLDEKVKNMNDKMVDIKVQKLRTNITQQTSLDKNKKTEEIIKDIKATYFDLKTDIVAANTIIHEKSRYGCGNLLERAVPLRERAIKFIKKASLTKEEIIELENEILDTEKDIENIKNEIEAETSIIEKSIKSYLEIEELYDNCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNY1</accession>
    <name>A0A0N5BNY1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNY1"/>
    <dbReference type="WBParaSite" id="SPAL_0000761000.1">
        <property type="protein sequence ID" value="SPAL_0000761000.1"/>
        <property type="gene ID" value="SPAL_0000761000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="446"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000761000.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="59591" checksum="9E1ECE4D16F11F6F" modified="2015-12-09" version="1">MISIPLTSSNIISDSNSKKEKILQCKNVVGVLIAHIITTILIYFQVFSINGSKGFLQHNTYTISILLICTFLIYALMFYCYSSYPANSFIFIIWIISSSLLTTNLIIYFDIEMIIQQFFILLSSMIVLMVILIVKNEKFEASKVLIITVTVSILAAIALHIVFLNSISETIINLFVTIGIGYYIVHSFNLSISKSKKDFIQQSIDIYINPIRNGINSTTEIYEITGLPTSNPSLINNEIQMLSDELYRLNNKIDILFTSVSNDSSLYQQVLALSIKTNKLLNSELVDLKNRAINASTKYTDLTPTLSDYIKKVQCLSNSGCIPTPSTISTTPLITTTLTSINDTLSCDKMKVNDEEISNDKIEEVNCNWNIISKIGYKYNFSLNSVTVQGNANIIIHDIINNKDVIALNNSITKPITINSNGYNYTISINSQDSISGVKFDIGYKKLNVCDVDTCANNGTCIVSPENTPKCTCSGCWMSSSNCQIKYDPCSTYLKCKTVDEDNNPTGNTCKTVETSTTCTAKCYCKDSQIGTAFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPA7</accession>
    <name>A0A0N5BPA7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Mre11_DNA_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPA7"/>
    <dbReference type="STRING" id="174720.A0A0N5BPA7"/>
    <dbReference type="WBParaSite" id="SPAL_0000773300.1">
        <property type="protein sequence ID" value="SPAL_0000773300.1"/>
        <property type="gene ID" value="SPAL_0000773300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="18">
        <location>
            <begin position="297"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000773300.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="61130" checksum="39405CDE5EAD33ED" modified="2015-12-09" version="1">MREEDTITITLASDVHVGYGEKKPGRKDDSLRTFEEVLDNARMTDSDCILLGGDLFHESNPTREMQVAVARLLRKYCLDSQKTCPLEFLSSPVDNFDHSDFPVVNYLDKNLAVSLPIFTIHGNHDDVAGNGLTALDLFHEVGLLNLFGKFRDIDNIVINPILIKKGDTRVAIYGIGSQRDDRLHRAFKEGRVIFKRPRDGNSWFNILVLHQNRPRRNFTRRTGGYIPDEFIPSFINFVVWGHEHASKPEPELVERTTNGIHHRFHILQPGSTVATSLCDDECGEKYCFLLAINGTEFVTTPIRLETVRQMMIDDMVLDVFPDRAKFAKTTVRPKNAPDEKLIKNKIQQMLEILSSSRTEKQPKLPLIRLKITYQDAFVGLPPINPKKFGFLFKDCVANPEDMFVVKVIKPKETNPNKEIKEEIKTSDTFSDVSQVVENYFVNAKGSEGLEIITEKSLGDALLEYGITEGTIESVNKAFTKSINDQVDMLCKVIDENNTTIPNYQNLVDMEKKFEEDIAVVRKLRRQNVPVNKSEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPE9</accession>
    <name>A0A0N5BPE9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPE9"/>
    <dbReference type="STRING" id="174720.A0A0N5BPE9"/>
    <dbReference type="WBParaSite" id="SPAL_0000777500.1">
        <property type="protein sequence ID" value="SPAL_0000777500.1"/>
        <property type="gene ID" value="SPAL_0000777500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000777500.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32675" checksum="F539A0EDA3E91E8B" modified="2015-12-09" version="1">MHALARSNLQHFIISYKEPSTVFDERKIIKLKKSDNTYSDIIDGRKNHRNMKALKESEGRKKLEQAKKKNVSFAIRALLPYNGCLDNDIPVPGKAVSFQVGQFLHIYEKFDSDWWIGRLVIDGSPLGFVPTPTKFQQIRTHRFKILQRALKKNNSSSTMEMTTGKGGQILHNQAMYYDIVPTMRPVCFIGPSLKGYYVLRKLIKSNDKCTVHEIKAQLAYAGSLLRIGENVFDLVLKENELSKVVKEIVSFLETYWRATHPNWEDIEKNMSNPSKSKISFSEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPH4</accession>
    <name>A0A0N5BPH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPH4"/>
    <dbReference type="STRING" id="174720.A0A0N5BPH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000779900.1">
        <property type="protein sequence ID" value="SPAL_0000779900.1"/>
        <property type="gene ID" value="SPAL_0000779900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="3">
        <location>
            <begin position="57"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000779900.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="38376" checksum="BC5DEFEB63AE62C5" modified="2015-12-09" version="1">MADYKSYNARRGGRYGRGRFGAGRRGFRGPRNNYRFRSSNKKNGEHFLGPFSEDYVKEFLKIRNNDKLTKAELKKAEEEFIAKQPTEIQEKYKKFIEDLNQKRNEFEETRSKKYEELSPEAKKLFDEVENIKKEENISFKEERNKIRSLLAKADNNVRNELRKINVTEKQTRPVRISEPKAGKGNKRSQEKREKTFSFLEGLDQEKIDEYLAIRKENKSLPKKEVNALEAAWASKQDEAVKKNFEEYVENVEKKKKQRLESNRATIDKLVTQLNTYINKLEALKLDPDTTYENELKEIKEVEYQTIRTLRYSTRSLFPRLNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQ69</accession>
    <name>A0A0N5BQ69_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BK_channel_a domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQ69"/>
    <dbReference type="WBParaSite" id="SPAL_0000803850.1">
        <property type="protein sequence ID" value="SPAL_0000803850.1"/>
        <property type="gene ID" value="SPAL_0000803850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000803850.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38808" checksum="5DCCA3B6FF139E72" modified="2015-12-09" version="1">MGQMKRPVKVNTIHSPVIPSPTGKSPSAVQIEDNACLDFRTSVMPRILQAAPRKREVFMILTTGVILIEPFQILKAYQSEVQPQWHLEARCLGKVQERQCVDQLSLIAVSQQYVLRLTGDPELFIHLPSRTKQCNTILVELSKGLGARVRDINICFSLNISYEIRGIASHVLLMKARLLLSNFTDQQWMALFVNCGIFSYPETVDTDIQNVLADYLSRYGLGTVNIINLLNFPRVKEQWEYEEEEKRKCENWVKEGKAIRKQGKYFTKTDKEIMGVILTSHAVESTPLGKLHMDLLQPGRRISKRTVAVFVAVDSLTRFIITGDLVKMLLWEIGEVYWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQH4</accession>
    <name>A0A0N5BQH4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQH4"/>
    <dbReference type="WBParaSite" id="SPAL_0000814000.1">
        <property type="protein sequence ID" value="SPAL_0000814000.1"/>
        <property type="gene ID" value="SPAL_0000814000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="162"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000814000.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36698" checksum="D535C020538AF19F" modified="2015-12-09" version="1">MNEYRLHHRGNLVRMEQRYTRLAESYLNLILTTSKTHIDRRILRYYVEIPYYFAPLIIKTWYDESKFYRYGTSVSITGTEHFTTIVWRSVKYVGFAVQEINDMIHFVAVFEPEPSGHYRSAVAYAHLINFRLKFCCGQNEYHEIPHELNILKKVGRCGFSNRIWRNFLNEINEYRLRHRAGIVKIKSEYTKLAEKYLNTILKTPKKYLNLRLLRNYVGIPFYFAPLIIKNWYDERKKYKYGTKVAIAGTEHFTAIVWRNVKHVGFAVQEKDDTIHFLAVFGPEPNGPKLFSSNVKGRSYFSSSRFLVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR26</accession>
    <name>A0A0N5BR26_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 299</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR26"/>
    <dbReference type="WBParaSite" id="SPAL_0000833200.1">
        <property type="protein sequence ID" value="SPAL_0000833200.1"/>
        <property type="gene ID" value="SPAL_0000833200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000833200.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12494" checksum="9A33071DF39557C3" modified="2015-12-09" version="1">MAITEDMELLVKRSPYTTLMKQYGVELLMKHLVGWTVNRKNKYLKKDINFLDYMTLSNIKILEVNVTKYEAGHIDVHPQGIGNSHNAQKQIFGVLYKDNEYFHKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BR81</accession>
    <name>A0A0N5BR81_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acid and retinol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BR81"/>
    <dbReference type="WBParaSite" id="SPAL_0000838500.1">
        <property type="protein sequence ID" value="SPAL_0000838500.1"/>
        <property type="gene ID" value="SPAL_0000838500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894740" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000838500.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16454" checksum="4B6C3FDD23F42CA8" modified="2015-12-09" version="1">MVKLLISLILLFNLINFSNSTKDVIVDKINNLDEVLLEVKDPATREIVKMIIDTMKFIEFPLEFGDKEKYVKNKPFVEERISQNLKMIGLLSSQINDQLLPFITQNFANSQDTSSDLFFDFIPLGKSKKFLENYLFGKKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRG1</accession>
    <name>A0A0N5BRG1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRG1"/>
    <dbReference type="WBParaSite" id="SPAL_0000846000.1">
        <property type="protein sequence ID" value="SPAL_0000846000.1"/>
        <property type="gene ID" value="SPAL_0000846000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000846000.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="76975" checksum="ACBF8530CBB9CC6E" modified="2015-12-09" version="1">MKLSESDKNRLRVVVATLKACDKGSRLSSNRISVLRLKNLKLAEAREKVRIYQCREIIKAEIVNQLPSTLEESIIEIPESSRSQISRSQIDEMGRMFMGLDDFDETKVSMSSFLRKLEGCLKFDKISDDVEKLDALLIKLSDDCAREVENATGYENAKMTLLQRYGEDMTEDHAQSQLQYFKFDLTKESIMVDLKQFARLVRISLPAVSGKDLTRSTRSMMIMRAQEHHHLWAFLMNLKSSETVQQLIMEVEAWHRLTRSKRDVEKRVTRQPVEFSRNTNTYTDNGTNKSVTKDVGNNKSRTIQCYECQEYGHYARWCPNKASEDNQMVTKRVFEEGYQRIARVQDDGWTMVSNAKTKKIVNGNSTIVSTDNDLCSKHDVGNDVIVRSASESYDFFVPVLFENNQVELMLVDGGSTRTMIKYSVAEGLGFKPEECKRVILANGSSWECLGSMKIRVKFPGNIICNVLAWIAKDEELEEMILGSDVLRAVKAVVSYDSKTLRFCGREIKHLRSNGKKDVMARAISLEYSRRVRSSTEENSKDILSVGSRDIGRCNNVNLSCEVPLMNRLKELKEHLEGDSSCENAFPQEKSVLGDDCRRILPSDEKEYILHSDAGGVVLEDVSIQLQDANVDKGGFNNIVEVADGVSELVTDSGNNKKKVKMKTETVVTSKPWEGYIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRH8</accession>
    <name>A0A0N5BRH8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="WBParaSite" id="SPAL_0000847700.1">
        <property type="protein sequence ID" value="SPAL_0000847700.1"/>
        <property type="gene ID" value="SPAL_0000847700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000847700.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47151" checksum="A12567E68395B027" modified="2015-12-09" version="1">XGILKQSLRVFNDKELSEKIKREKFDLGITETMNVYIFGLFKVWGIKAHVAGFSMSLGDNLYEIFGLPFPASFIPTLMSSSTDKMSYSERFENLFVHYFGKIFFYFLKDKLTLQSEFDRKYGVGFYDGNNVVGDSSFLLLNSNPFLDIPGPKTPKMIEVSGIGVKDPKPLDKYWDKILSLRNKTVLVSFGTFAKSIDMPEDIKNGLLETMRKLKDITFIWKYEEPEDGTGKGIENLLLSKWVPQNDLLNDVRLSLFVTHGGMGSTTELSFRGVPAIAIPIIGDQMRNSKLILRQKCGIIMNKFELADSSILIKNIKTILDDDSYKENAKMVSKRLNKRPIGSKRLLIEHIEFAAEFGRLDMLDLASRHMGMIEYYNLDIILSVITGLFILVSFLFYIIFMTVKKLFISKIKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT78</accession>
    <name>A0A0N5BT78_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT78"/>
    <dbReference type="WBParaSite" id="SPAL_0000906600.1">
        <property type="protein sequence ID" value="SPAL_0000906600.1"/>
        <property type="gene ID" value="SPAL_0000906600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894980" evidence="3">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000906600.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28426" checksum="03572EA3E840F026" modified="2015-12-09" version="1">MLNKFLTVFLLLSTVFVNTNAQYAYATDVMGSFSVSQFRCIKSNGYSAIFTQIYSAANGGLVDATGSQNVLNAYQAGLGTEVYINPAPKSTKQSYVQFDESYKQLRNANINVRTIWLKVTDPVLWYQNPSYNINFIQGMITRARNYGITLGIFTNWYDWYQITASTTTFQQYNLPLWYWDVYGFGPSAEGSRDFSDFRSFGSWTSASAKEYALTEWLCSAAISKVVYFKSNSNLKLLSDKNMTQPVAGSAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU66</accession>
    <name>A0A0N5BU66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4371 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000938700.1">
        <property type="protein sequence ID" value="SPAL_0000938700.1"/>
        <property type="gene ID" value="SPAL_0000938700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000938700.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18417" checksum="0E87ED430B553213" modified="2015-12-09" version="1">XYKKVNGPVDSNHIPLADRRKFMGFLLDVYTDNISITMRKTDNAAAVFLEIVCEELDIQKNLLNPLYFTRALNQRVQRNRPSTLKEDLINPAEKTLVASIDKCSKFKTAGEYVFKILSYDDPKTYFVNNYQHMYYHLLSQKSTFNVENISLGLAKIKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVD3</accession>
    <name>A0A0N5BVD3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVD3"/>
    <dbReference type="STRING" id="174720.A0A0N5BVD3"/>
    <dbReference type="WBParaSite" id="SPAL_0000979600.1">
        <property type="protein sequence ID" value="SPAL_0000979600.1"/>
        <property type="gene ID" value="SPAL_0000979600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="735"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000979600.1"/>
        </source>
    </evidence>
    <sequence length="874" mass="100109" checksum="D34ABF5266B865E8" modified="2015-12-09" version="1">MQIDLFKYLRKRHFGEKDGQFNKKINELRTKNHAEILKVDDALTKRAQKHVEESAEKRVDNINNESAGVSFHIAESESKYDPLSMWTSESTVIDYDNLENGPTPKRFTQLICISTTNIGCGLTDTERENNEIKYLKERQADKKEGQNEQTIAEIKNNKKKVIIKKPIAGKNPRKRPPFPRPPARRTTPRRPPLRRTTPRRPPARRTTPRRPPGRRTTPRRPPARRTTPRRPPGRRTTPRKPPGRRTTPRRPPLRRTTPRRPPIRKTTARKPPARRTLPRRPPPRKTTARRLPTTRPPIRKTTARRTSTPRSPNKRPQTRKPGHRQPLTKRKTKKQTTPKKPSLKPLTIPPTRHQTQKTITTTTTTTTITATTTTLKPDEYARLKSQLIIDINNLRLKHKAKELIVNTTLANQAQKVADDIKNILGNIDNSIGWLLNFAGLEDESTPSTERTAESENIVYGKPDGEPVPEEVAQLVWASTTDIGCGISKIDTENIMVSICMFYPHRKNPENNVENNDSVSLDLIRNDLSSKKFAGHDSFVHSKSRISKNNYLRKRQIENKGVQREESSFVSKKSNNEDNKRQARIIQGKKFTGISPLGIRPPYPRHPNRKPPIKRTTPRRPPVRRTTIRRPPVRRTTTRRPPIRRTTTRRSSIRRTTIRRPPNGRPTTKKLEPRPTLPKRSTKKQTTPKTTLPRPPVRPSVRPPLRPQTPKPTTTKRATTTTRSTTTTVKPDKYAALIAKTISDINNLRLKHQAEKLTVSATLAKRAQKIADESHEKLNDINDDSIRLIFYHARSEREFDPLSFWTIGIQDIDYNDLNERTVPLDFAQLVWVSSKEIGCGISELKDNAGILTICLFSPKGGIPGQYPENIRRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWY0</accession>
    <name>A0A0N5BWY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001031900.1">
        <property type="protein sequence ID" value="SPAL_0001031900.1"/>
        <property type="gene ID" value="SPAL_0001031900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001031900.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29778" checksum="7A1D4B690C72C185" modified="2015-12-09" version="1">MKKNELLFKSKKANVSSDLQAKTLQVNNCSKIKPVSGELNTCKDRKIPVKSTSETNEIIKREIIDQQRNSFLRRKSTIHNGYQYCIQRCGSKCQNCDNPVILKSKKVICCENKPWYLNFRTPFWYLLSSRHIDSMLESTNMPVSCQSCSKKFVRSGCGMIKHVVEEHLSLKGFLLKCRLCKLETNNITQLVYHWGLVHNSTGLSFFNNLVWRCPSISTTYPNNYSIEVTKESALKIEKYVRKFVKCFPLVKTQLSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXA0</accession>
    <name>A0A0N5BXA0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="5">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXA0"/>
    <dbReference type="STRING" id="174720.A0A0N5BXA0"/>
    <dbReference type="WBParaSite" id="SPAL_0001043300.1">
        <property type="protein sequence ID" value="SPAL_0001043300.1"/>
        <property type="gene ID" value="SPAL_0001043300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001043300.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27137" checksum="A1E6C1D5EFD3ABA6" modified="2015-12-09" version="1">MLSTSTISRKFYNNILKQFRYISRSVYNEDVCIKVSESDEVLGGVGKVECHKQPLSLHRAFSVFLFNEEKKLLLQKRSLKKVTFPGVWSNTCCSHPLYNDKEINGKDNIGIKAAASRRMGEELGLWNIPEDNFKVAGRFLYKAVMDDIWGEFELDYSLILRNTGISNRCKLNKNEVDKVMFVSFTELQDMIKNGEQFSPWFMLFNKQGFIEKWFDSLDNNTFINDPSFIYKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXQ0</accession>
    <name>A0A0N5BXQ0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXQ0"/>
    <dbReference type="STRING" id="174720.A0A0N5BXQ0"/>
    <dbReference type="WBParaSite" id="SPAL_0001057200.1">
        <property type="protein sequence ID" value="SPAL_0001057200.1"/>
        <property type="gene ID" value="SPAL_0001057200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001057200.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17835" checksum="9344AA0344361C67" modified="2015-12-09" version="1">MYQNSIPVEENNEEGGNNRYNGSNIQDASKMPWDLRVQCFIGCFILSIVASFCSSFLLVQGKLTGYTVLVSIGSVISIIGSFFLSGPAKQLRNMFEEKRVFATCIYISSIIMSFVAALVLKSVSLAIICIIIQYLAMAWYSLSYIPYAHNFIKKLFSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXW4</accession>
    <name>A0A0N5BXW4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXW4"/>
    <dbReference type="STRING" id="174720.A0A0N5BXW4"/>
    <dbReference type="WBParaSite" id="SPAL_0001062700.1">
        <property type="protein sequence ID" value="SPAL_0001062700.1"/>
        <property type="gene ID" value="SPAL_0001062700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="490"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001062700.1"/>
        </source>
    </evidence>
    <sequence length="691" mass="79874" checksum="EAB3769A1E5F5AD1" modified="2015-12-09" version="1">LGNNLREFNYGSTIDLHQGYFQMMLHEQDRPYFSFKYKYKVYQFKRAPMGAKNSPSFFQSNMELLLADLRTRVQGHSNIFVYMDDILVLTKGSCQLHLTVVEDLIKIIHQKNRRISFNKSCFLRTSVSFLSWTFSRNTITPTISPHLLHKPLPITRKELYSMLQCFNYFRLSIPNFHERTKDLYQLSKGPRNEKVPWSQDLISKYRQFCQYLFNSPKIYMYDESQPLILRVDGSNSGVGGFLCQKDVSGIARPLGFFSYPLQHTKRPRAPTFIELTAISRGISTFRYLIQGKPLTIESDHRPLAGLIKSSTSPKFMEQISSITQYTTDIKYINKESNLLADMLSRLFESSHVEVNQVSHPRPRGRPRKLLPVPQEKIYIDYESLPLNISLIQREDEELVNSLKDGKFRGIDIEEQLNGIIVTKDSRLPIITDDQTIASILKICHDQSGHWNHVATQEIIQNHVYIPNLPEKCKSYVEHCDTCNRFNSKKHEQAPSVDQDFQVFECLSADAVGPLESTKNSSCHIMLYVCPASKFVIAHSMKELTGKSIINSLQLIKSSYTLPRILRTDGAKYWTCKEVESYLESNQVSHSISTPMNSTGNAYAERYIRSLQTVIGKFLLDNPSLQWDQILPDAIYSINHYPRHGTTPYQTMLRYKPSTRLQLALQRNLENNELNDLKTRMTMLNSLFSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZD6</accession>
    <name>A0A0N5BZD6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metalloendopeptidase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZD6"/>
    <dbReference type="STRING" id="174720.A0A0N5BZD6"/>
    <dbReference type="WBParaSite" id="SPAL_0001112700.1">
        <property type="protein sequence ID" value="SPAL_0001112700.1"/>
        <property type="gene ID" value="SPAL_0001112700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF802">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733467" description="Metalloendopeptidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="36"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001112700.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44976" checksum="08CF16617314D628" modified="2015-12-09" version="1">MIASTFTKMFFSILLPLLGLCIPIESNDEDYLRRDKRIIRVQNNFNYTKPVKYYIDTNINNKKNILEALNHLEHYTCLKFTEVKQTLKKDGINFYKKPDLSVEYKYYKDKLSNVSITLQCLKELGCMKHMIGRAFGLHFETARYDRNHYVKILWNNIEQQSKKLYSKVKGFKSRYFNTAFDYGSIMMPNITEGAMKGKKAYTTKGSKLYENMVGQREEFSFSDIKKINDVFCGGQCGKKLRNCKNGGYPSPNCGICNCPSGYKGKYCEKLEASQGDCGKRFLYAKRREQTLTLKGLKKCVIGFYSKPRTNLALVVKKVKTTKRTPCVENKGIEIKYRHDKGATGLVLCGSYKDVVIKPTFSRAVMIYLGQNKDDMITLSYREVRRTSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZQ5</accession>
    <name>A0A0N5BZQ5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZQ5"/>
    <dbReference type="STRING" id="174720.A0A0N5BZQ5"/>
    <dbReference type="WBParaSite" id="SPAL_0001124600.1">
        <property type="protein sequence ID" value="SPAL_0001124600.1"/>
        <property type="gene ID" value="SPAL_0001124600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001124600.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22775" checksum="2E8FD1EAE424D59A" modified="2015-12-09" version="1">MGKYKSTAKFARNRVKQIKATDERISEDKRKINTKKEDDKKIKLIEAPKVSSAMFLRYNTQLGPPFHVIIDTNFINFSVKNKIELMKGLMDCLYAKVIPYVTDCVFGELEKNGNRFKVALKILKDSRVRRLKCTHKGIYADDCIVDRIKQHKCYIVATCDKDLKNRIRKIPGVPIMYIANYRYTIERMPDAFGAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C018</accession>
    <name>A0A0N5C018_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C018"/>
    <dbReference type="WBParaSite" id="SPAL_0001135333.1">
        <property type="protein sequence ID" value="SPAL_0001135333.1"/>
        <property type="gene ID" value="SPAL_0001135333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001135333.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13841" checksum="D952CAF9623BEAA2" modified="2015-12-09" version="1">MPVQFSSLSVVVKRSWLKASERILKPVTLTLKNTLITSWDGDNNIIDQKNLDLDSLDGEVNYEKSKNKTMLMKLRRFFWSFFCKHLSNINRKHLSTGDVEDGFLSLYFSLIHYIIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C047</accession>
    <name>A0A0N5C047_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein-like (inferred by orthology to a human protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C047"/>
    <dbReference type="STRING" id="174720.A0A0N5C047"/>
    <dbReference type="WBParaSite" id="SPAL_0001137900.1">
        <property type="protein sequence ID" value="SPAL_0001137900.1"/>
        <property type="gene ID" value="SPAL_0001137900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="194"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001137900.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41360" checksum="7E730326371C3186" modified="2015-12-09" version="1">MVLNRKRKNNDISADDSSNIQPKVNKFSYVFSIQNFSLRTEKTGEKITSLNFFTGWKNKSQWNLSIYPNGQSEDSKEYVSVFLTLIKPDKAKAKYKFSILNEKEEEKNVINNGITKDFVKNEGWGFSKFVKKDFLLDVSNGLLINDKLTILCEAEATTFRSDNQNNLDTSKNITIPQSTLLSNYADMFDSSLFTDFIIKVGDTEIKVHKAVLAARSPVFHNILSSPLEESQTNAIKIEDFRVEVVREMLNYIYKEKISNIQNMADEMFEIANKYELHRLKAISEQSLCNNLAIENVCERFALSEKYSIESLKKCCIELILENVRWLTKTKEWKQFVLVHPSLVESLFLKAINISSIECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1I3</accession>
    <name>A0A0N5C1I3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1I3"/>
    <dbReference type="STRING" id="174720.A0A0N5C1I3"/>
    <dbReference type="WBParaSite" id="SPAL_0001185600.1">
        <property type="protein sequence ID" value="SPAL_0001185600.1"/>
        <property type="gene ID" value="SPAL_0001185600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="573"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001185600.1"/>
        </source>
    </evidence>
    <sequence length="856" mass="97098" checksum="AAF7D3FA01BECBDD" modified="2015-12-09" version="1">MYFIITVIISNLIIFNESIGNFNNKNVENIQVASLYTLHTGNRGILCDTLVPENVILLLVHDYAIQYINRKYLNDIGLTVTSNYADTCDDTSITIQKTVELVGGSQYCQDVQPISKPLISNDKNYTIASIGCFSSEIGATIVYLFQAFCIPVISAISNSVLLDDPKTYPYFVRAGASNYYKMQTLIHLIQSQMWFHIIVINDSTMLGTSMSKTLNNILSPCIMIDTRDNLFRFPCVERYLEIPFDNPEKSSSATYSALLDLKTLLQSTSARVIVLLMESQNVNILLNQNFWNKTKFQYQFVIIDSDELEINPLLNYGILIEEHVEPFRPLDSIVMSIVLNETSNIYVQELIEMQHLCCWGMDDKCPYSIKCTGDEKIKDINKAARRQAGLVFNAVNMLGVALKDFHKVYCNNEWGLCDNFIKNAYGNILMDYILNSTFLSYDNSIFHLYNRSAYPEYDIYQYINGSFTLLINKYQTIKGPQKNPTSKDILQSKLRNDTEAENNNCQIDCSLNHAIPMTIDTCCWTCKECRGPDKYVDSSISCKSCPTDKIPAPNKSACIPEPIPPVFIKPNAGKIICLVISSFGVLISILSLIFLYSKKGTPMYKASTPDLLYSQLLACFGLNICSGIMMPTSNIYICIIGWGGCTLFITTIQANYFAKAIRIGKPKYIEKLNFISTNLRTSSHIFVAFCGAIQLIIFLFWLLLRTPTINKDNIRLRYCSTNSDYQTLILFTISFILLCLSLQPLRLALKNRYIFQVRQAGFCFLGLLCLAASYPVLFILLYTQDLDDQANSIVGMLVGLVPANIAFYTFILPSLWQMIFKRSQNLHEYISRERSRQFQVGNIMYYVDAVVLQNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C273</accession>
    <name>A0A0N5C273_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C273"/>
    <dbReference type="WBParaSite" id="SPAL_0001208600.1">
        <property type="protein sequence ID" value="SPAL_0001208600.1"/>
        <property type="gene ID" value="SPAL_0001208600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895225" evidence="2">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001208600.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="59502" checksum="7157F778248C399D" modified="2015-12-09" version="1">MNFFILILFSCALFSVSKGESIRDVRDVFQGLYFNDPASRSLYEYLDLSIDPCDNFYQFACGEWIKTQKWKYKDYISFNIKNRNVNFNKFFKGKNFFVFIYLLLEFEEGKYNRESKAINNIYNLRDKCNRLPNVEIGKCKKEVLDFGTYAVSALFLKKNEIKSEQNGDYALIEDMIERIKFELELLIDDKRDMFDEETRNYFLHKLKTMKFQKEYDLYEFSNIDQMENCYQNIGKIVFNLTSIKDALNYIRQVKNYRPMEDHRFGFCNGEFFHPQKLVDSYVYGNAKYNNGQNYFSINSDYLNEPSFSINFPLSLNYGYLGTAIAHEMLHAFDRKNYNRTFEGDNIINFNVTQMSVENFEEKSKCFVKQYDMQKESITNKNINGLQTLNENIADNGGLKIAHRAYSRYLFTTADNDTIVRGFEKFTKIQLFFISFGRKRCEYRSKDSLENSIRKSVHTPGEIRTNVALSNYKPFSEAFNCPLNSKMNPENKCELWKNQKQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2L8</accession>
    <name>A0A0N5C2L8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2L8"/>
    <dbReference type="STRING" id="174720.A0A0N5C2L8"/>
    <dbReference type="WBParaSite" id="SPAL_0001222800.1">
        <property type="protein sequence ID" value="SPAL_0001222800.1"/>
        <property type="gene ID" value="SPAL_0001222800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="185"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="433"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001222800.1"/>
        </source>
    </evidence>
    <sequence length="711" mass="81791" checksum="92D8EC2F95AAEC1E" modified="2015-12-09" version="1">MTNVRLYTNPDEPTILKIRGYVLFNSLDQIKPSSLITMGYNAGNPCKISFLNRSVQRNNPYLFDHNETIHSVSGYMTFAKPYNINNNVCTGVDVTVDVPYDDNDDINKLSFYMRSLYKTSSIEFKCIPSGITPFIDQDDAVEKLRYFWRSNISIPLLSFLKENYSSDITFRQMSYSGNLLYDETLDECQRDLANSICSGTKLITCLAPAGCGKTQSICSALLTGVAQGKKYLVVGPTNKSCEAILDRLFTWDPDTKAVLSLKSRCAMVRYPDKYNRSDIYYYRQGLDLITSQMTHDDRRLLDNYKRYKADYGSLKNSPPTVLDKDYFNRLNNAKSRLKNAETLLPELIMTYIKPKIIVCTIDLLVVGIPKAYTQCGFDNIIVDEASQVRCSTAILLLNLFPDSRICYLGDMNQLPPYALYKVTLDEKELLLSRPILQYMKDSEHGKTILLKYNYRSHPQLVKFVSDLFYDGSQYPKKNLQDCDTEMISFKTDEDDTNQQIYPYYLFNINYPSNQHPSGSTYNRGEAMCIGLVLLFLHSINYDPDEVVVISMYKAQVNTIHRKMVEIFDDYQSYMNADDSLKQQMEDFKYTLDNYRNKIVIDTVDGFQGHEKNIVLISTTRSTANPEDAKTEFYELKNRICVALTRPKIGFFLFGDVTLMKQCDTWGKVASRMENENTVLTFDHTNLLNIFQNHGPPADFFKNQLHRLSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2R8</accession>
    <name>A0A0N5C2R8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2R8"/>
    <dbReference type="WBParaSite" id="SPAL_0001227900.1">
        <property type="protein sequence ID" value="SPAL_0001227900.1"/>
        <property type="gene ID" value="SPAL_0001227900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="486"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001227900.1"/>
        </source>
    </evidence>
    <sequence length="747" mass="82649" checksum="5F9F7F962D108E09" modified="2015-12-09" version="1">MGKKSKLNTSECIDTCSENAICEEGTCICLEGFIGDGIECQDKDECETGEHICGEHSKCKNIFGAYHCVCDPGFIATEEGCIDDNECEKETALCGKNSLKNQTTDCINIIGSYECKCKSGYFGNPGTVEGCLDINECTSIDNVCGEHSTCINKAGGFNCECDEGYEKLSSNSTTCVDMDECLHNPCHPAAKCTNLPGTFNCECNEGFIGNGVDCKETILYSSKNIKNILYVEHIENSINEISLIPNLMIFGKDYDKAYISSNGIISFGSKKNSFQELDKNSVAFIPLYQNFNLKNSGIITVNHLSSNDTSSKGFLSRSDYNIYQRYNDHHFHTQSLYIITFENVFNQLKTQPFTFQVIIASNINKTYLTMLYEEIGPLDNSNNQAKAGIFNKGNFYQLTTNLLITKSNVKQPGKWIFRIDQPSITSCPIGSDEPPFCMSTCKPGFFGENCSKKCNCADDIPCDYITGYCANLECNKGFMGPDCQIDVDECETGEHFCHKAAYCTNKIGSYQCHCPMDMIGDGIHCDPINPCFETYGKNCSTNGICVNFKNEKPTCNCLKGFIGNGFECTPLPPSTTIQSIITKKLTLPPKITISVNTTLPLNIIEPNEIQIKGNGVTSEGKIQKLEPLGKPNNIFTESHSSINPKNIITTSFRPKISEQEAKILLDGTKNSDMDGTFNVLLFICTVVFAVIWMIVAIAIIATCCQRHSRSHRQKYDTTIMHNWSATTATQAAYTSPRNNNYANFAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Y4</accession>
    <name>A0A0N5C2Y4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Y4"/>
    <dbReference type="WBParaSite" id="SPAL_0001234050.1">
        <property type="protein sequence ID" value="SPAL_0001234050.1"/>
        <property type="gene ID" value="SPAL_0001234050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001234050.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7347" checksum="141EA8D6D7783D2A" modified="2015-12-09" version="1">MEEINRFGSSESLSSTQTLISSSISMSVFGTPETSAIKGLNTTIDVFRLSPGSISIMSNMTIKTPLMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4B1</accession>
    <name>A0A0N5C4B1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4B1"/>
    <dbReference type="STRING" id="174720.A0A0N5C4B1"/>
    <dbReference type="WBParaSite" id="SPAL_0001279200.1">
        <property type="protein sequence ID" value="SPAL_0001279200.1"/>
        <property type="gene ID" value="SPAL_0001279200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001279200.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40479" checksum="4A3D6F2144E9F02F" modified="2015-12-09" version="1">MWEHALKSNPNKEIIGVREGSIALACFKFGLPVVTVYSTLGCESVAYASSETNGKYLFTNEDQLNKLEVIVEKIKFLSKIIYFKDRFSKKSFDINKLKNILKNNSSNNILTKVDKNDPAVIKYTSGTSGTPKGTILTHQNLIAGLSGINSHSQLDGFLGKSCKVIATYLPLAHFFQLIVDLKCLSSGIKIGYCTPHTLINGSVRLHSESKSDLEELKPTSLAKKDLVKLSHGEYISLGKVESKLISNIYIDNVCLYVRPDRSYTIAIIVPNKENIEKLDKNLQVMGDFKDLCERDVIKKAIIESIQESISTVLNKYEIPKKIILSPYIWTSNNGLITDAMKIKRKAIEKEYFNKIIGVYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4I3</accession>
    <name>A0A0N5C4I3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4I3"/>
    <dbReference type="WBParaSite" id="SPAL_0001286500.1">
        <property type="protein sequence ID" value="SPAL_0001286500.1"/>
        <property type="gene ID" value="SPAL_0001286500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001286500.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20088" checksum="B8404372F1ED1AF0" modified="2015-12-09" version="1">DLEIRCNNEAPKSQVYPPPEMFFAQSPLLPSPPLQFYDNCSKNIIFQNQPTILPTQPQILDVAGPEEMVVDLESDKSMDTQDFSPNFVIHDLQAFDLIDSGLFVHNALSKRKNSNLCFIKSNPEEKDLLKIRGNTYFLKKVYNKSRKEKTAKFDFSSQTGNFRCKECKKAENSSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4U4</accession>
    <name>A0A0N5C4U4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5C4U4"/>
    <dbReference type="WBParaSite" id="SPAL_0001297300.1">
        <property type="protein sequence ID" value="SPAL_0001297300.1"/>
        <property type="gene ID" value="SPAL_0001297300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="594"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001297300.1"/>
        </source>
    </evidence>
    <sequence length="1352" mass="155204" checksum="D8FAE103BFFBF488" modified="2015-12-09" version="1">MVVTRTGPPTTQKDGQIIDNHVQPTNTDDMHQIVRLLTEQKETMSTLMTSISNIESRLQQVEIKQNQIREYPTTPEGGRTLNDPAAEDHKNGRNKNKNKKNNRQPIKSPKINQEDDDNDGNYHNISQLSSQIEALSINSSTGNKRPPNISLEKFNGKISFQIWLKKFMAYCKINSIDSDMKHEVLLLMLEDEPASDANRIELYDFHTLSSFLCNKYKGQYSIASAFHELEIITSRPVRKPEELDATCKKISDIIEILEESKPTDYILQRKIEALSKVLPLELRSKILLTASIFPSFDVAISSTKRAWALDYRADIERSKGNTLSKNKKKKKYCSNCNTNTHNTDMCRLKDKNKHRKEKINKVDDEESSMDSSSSSSSSEDEESVYKISESIEKNLESISNKGLIGTHVTVNGHSCVAMVDPGSTCTIIDKEFARKIKIPIRSENGKQVEVLSNTATVYKIKDTITINVLGYDIKLNSRIYISNTNFYNSSYQVILGNNILKKVDGKINTKKDHDEINFVFEKANGDNKLEEKLRQQLQIDFKDVIAQHDFDVGKGQVQTPLQEYYEEREPLKIRYYPVPLNDRVELDKITDMYLKHDIIEKCDSTHIAPVMILNKPSEDPSIQRKRFVLDVRESNSVTKYVNYEPPTLQMILNSIRKYQFASSIDLCSGFLQLSIPEEIRDRYAFKTSKGIFRFKRLVQGARNSPGIFQRTMESIFAPLKDNMLIYQDDLLVISDGNEAQHKELLYQFFSIARQHGLKINFNKSKFFKKIVSFLGWDISPTGVTPSLKSVESIMKLKLPVDKKQLYQRLQKFSYHRLAIKDYAKLSSKLYEMTSGRNCKIELTGENLKNYLTIVETLYKQPLLYHANPSKPYILTCDASATAVGATLSQLDDSQIERPISFFSCKLPHVKKPRSATYNELYAIKRALQFNKYLLTGAHIKIRSDHRPLEKLVQNTQEKRFYDLVECINSYNCSIEYIEGVKNSSADCLSRLPHSDVSSESDAEKEEVNILLRKKTKKNYNEVKVMRNIFKPTSTDTLKDENKINDDKKISSLKNNLNDDKTISSLKNNVISLEKRGPGRPRKKVMKDDAKQSINDALKDNEDINTPQIANEHSFLSNKDHSSCINNTTLFHTILPNNFNIRDKQQLDLEIIAAMKSKIYDNKPIQVINGIVHVQVPSKEGGNDLLPIIPSDPETCQLVFNICHTQSGHFGLEKSLEFLKTYGYLKKSRKIFEQFYKECVTCAEVNSPLQKHCEMKTVQYSRPLSEIVQYAKKALVNPKYILEQSHFKEGDKVYAKLPDFSRGRKLAKKWKGPYTIEKMEDAVAFITLDNLPKKKIRKLHIDKLKKFRSNKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5S0</accession>
    <name>A0A0N5C5S0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-1,2-N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">GlcNAc-T II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mannoside acetylglucosaminyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12941"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="EC" id="2.4.1.143"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 16 (GT16) protein family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.143" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5S0"/>
    <dbReference type="STRING" id="174720.A0A0N5C5S0"/>
    <dbReference type="WBParaSite" id="SPAL_0001329700.1">
        <property type="protein sequence ID" value="SPAL_0001329700.1"/>
        <property type="gene ID" value="SPAL_0001329700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008455">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007754">
        <property type="entry name" value="GlcNAc_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871:SF0">
        <property type="entry name" value="ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871">
        <property type="entry name" value="BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05060">
        <property type="entry name" value="MGAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 24" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="166"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="277"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="316"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001329700.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="49312" checksum="63FD874BD376CFA1" modified="2015-12-09" version="1">MNISEILKSSQNVSTETRLSSIGLPPDEVVDMFNYINDNYEMLNKKKFENKEILYVILVQVHDRLEYLQILINSLENVKGIENCLIIFSHDVYKAEIDRPIKNITFGRVLQIYFPFNLQLFPTIFPGLSEDDCPPSMAKTEAYRVNCSSRDQFDTYGHYRDPKLSQIKHHWWWKLNFAFEKIFKKLKITGKIILIEEDHYVMPDMIHVLDLVTKEKEKLCKSCNIVVLGSYKYNNRTYVENINKINVMDWYSSMHNMGMVIDNNLWNNITKCSELFCTYDDYNWDWTLLQVSLNCMVSRMRTLLVTSPRILHIGDCGTHKHDCQSQKSLKIAKDLLEYSKNKLFPNEMSIKEEIKKSPKASRPNGGWNDLRDRHLCLHNSYMLPINKNNSHFSCQYSHYKNKNGFFPFMDLDFLQNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5X1</accession>
    <name>A0A0N5C5X1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5X1"/>
    <dbReference type="STRING" id="174720.A0A0N5C5X1"/>
    <dbReference type="WBParaSite" id="SPAL_0001334700.1">
        <property type="protein sequence ID" value="SPAL_0001334700.1"/>
        <property type="gene ID" value="SPAL_0001334700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001334700.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19867" checksum="F78C3E16FD34CECA" modified="2015-12-09" version="1">MALPLDEYVDKLFKVWDIIDFIKTRNCGGDETKEKIEWFKEVCVEYASDKDNTDAMEFTDWIETILNDEFNILLEEDSGVILATKILKYSDALRKNDEKLASEMAEHAVKTLKERKSDSQSKRQVEGDSDDEDGSTDGSSDEEMEVDEGKEKKERQPKQVTDDDGWTTIQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C645</accession>
    <name>A0A0N5C645_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C645"/>
    <dbReference type="WBParaSite" id="SPAL_0001342000.1">
        <property type="protein sequence ID" value="SPAL_0001342000.1"/>
        <property type="gene ID" value="SPAL_0001342000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF4">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="52"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001342000.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="32444" checksum="3BEB80CF7A67C436" modified="2015-12-09" version="1">MTKIFGNGEFMLPEWEKCLTSSFYIPYLTYLLFFFINGSFIRKYFWQKYTGFKKYRLENLSMSLFHATVTGLFALIFTFLHPYEMFFEIIHWYQNWANHVLFFSLAYFTYDLINITMNEQNKYTVELFIHHTTSIFVFSCSIFSGKFQLYAFWALLMEVSSIFLHIRTISMISGYAKDNCENHRIIQIINVITCLIFRFGVQVWQISFILINKNLVHPFYFNVGFYGGLFFIIFNTILIFRLLASDGFLCEKVRIFVSIDRDNAQTEYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C668</accession>
    <name>A0A0N5C668_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine Receptor, class Z</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C668"/>
    <dbReference type="WBParaSite" id="SPAL_0001344300.1">
        <property type="protein sequence ID" value="SPAL_0001344300.1"/>
        <property type="gene ID" value="SPAL_0001344300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001344300.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34666" checksum="94DE17BACD61CFCB" modified="2015-12-09" version="1">MSKENLTKDELTNQISEEEGFQIKYLTHLQIGIIYFLFSFFSIILQLLVFSSFYYKRELLKRKCFIIIFHHGVLSFIQQICHILTSIIIIFYIQKIELLLTIIGSLLNSTFIGSILFIFLLTLNRFDVFYNLNFFNIIEKRKFYHYAIIVCYILIVGLFSIYLYPSFSTTFDLKIYQWKYVHSKNCHLGYQLENKTIYIFLGISFLLQALIVIKIFKLRCYTSKPILLIYENFRILIHAFMCFVTTLFLELIWSGIIFKFYWKGSWLILPTILFIFHSVSNSIFILCFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C670</accession>
    <name>A0A0N5C670_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C670"/>
    <dbReference type="STRING" id="174720.A0A0N5C670"/>
    <dbReference type="WBParaSite" id="SPAL_0001344500.1">
        <property type="protein sequence ID" value="SPAL_0001344500.1"/>
        <property type="gene ID" value="SPAL_0001344500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="72"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001344500.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20014" checksum="8E23F39804DC899A" modified="2015-12-09" version="1">MLNRSLTSIEEAMTNVQSHSTFNRTYERKVIEEGTKGSPITSTSILSGIPVMSAIPASFHIQPHSLINNHHLNFGGINTSTLFSTSDNHLEVILDISEYGADNIEISISNNYIVVKASHPEKEDQMGLISRSFTRKFPLPTNVKPDAVESNVTGDGKLHIKAFAPKDQNKGETKSIPIKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C703</accession>
    <name>A0A0N5C703_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C703"/>
    <dbReference type="STRING" id="174720.A0A0N5C703"/>
    <dbReference type="WBParaSite" id="SPAL_0001371800.1">
        <property type="protein sequence ID" value="SPAL_0001371800.1"/>
        <property type="gene ID" value="SPAL_0001371800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="579"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="724"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001371800.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="91806" checksum="55FB127D5F35FC58" modified="2015-12-09" version="1">MLRRGKVDSKDSSRYSAPSNEKNSEIEVNNQSNGTTNVKNNDDGEQGNGDSNNYPPRRKKSIKRRRNKFLKSQVSVEPIGINLSSNNIISGPRPMTVAGKNREDSVDKGNENNNNASENRVNLPTVKITVPGTVNEQDSELTDLDQDGGVEVDDSIDIQKRDSPVLDNSPSPPKPAQTPAPNKEPPKENKDNKDNEANQNKQNGAIQPDKPPNKDSNNKASETLPTDVSSPPEVPKVTYYNKLKEFLKTFVADKTTDWYYYWTGVVSIAFIYNLIVIIARVVFADLNGGLMWIVWLSSDLISDIIYVIDIFVKSRTGFLEQGLLVRDTKKIWASYKSSTEAKLDVACIIPLDYIITYIIFDKPIARFNRLIKVERIKSFMETTETRSSMPNVFRVFTVVCYIIVIIHWNACFYFAISELIGLGTDSWVYGALNTQSLPEGVEDTLIRRYIYSFYWSTLILTTIGEVPGPVQNIEFVFVTFDLMGGVLIFATIVGNVGSMISNMSADRTEFQNKMDSIKQYMELRKVSKALENRVIKWFDYLWANKQNLSDQQVLKLLPDKLQAEIAMHVHFETLRKVRIFQDCEAGLLAELVLKLQLQVFSPGDYICRKGDIGREMYIVKRGKLQVVADDGIKVFATLQEGSVFGELSILNIAGSKNGNRRTANVRSVGYTDLFVLNKQDLWNALKEYPEARKMLIAKGREILKKDNLLDENAPEEQNTVEEIAEELQNSVRVLQTRLARLTAEYTNTENKLRNRIEYLEKRLRKYQVISDIRNDDYLDTESIRQSLSSQQQARKKALEYKQKDKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C748</accession>
    <name>A0A0N5C748_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Col_cuticle_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C748"/>
    <dbReference type="STRING" id="174720.A0A0N5C748"/>
    <dbReference type="WBParaSite" id="SPAL_0001376300.1">
        <property type="protein sequence ID" value="SPAL_0001376300.1"/>
        <property type="gene ID" value="SPAL_0001376300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060102">
        <property type="term" value="C:cuticular extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042329">
        <property type="term" value="F:structural constituent of collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF393">
        <property type="entry name" value="CUTICLE COLLAGEN ROL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001376300.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="32970" checksum="D113ED1C2B32B3C8" modified="2015-12-09" version="1">MSISTATSGALFCSGLTIVLCLYAIITIQNDVASLKNQIDNEIDSFKILSDDIWGNMVNLGAGSPKNRQRRQSYGGYGASGSNPSYGGYRGGSNPPTTHPSSHVPTGGFPPMTPGAGGQEQGPGGPQCQCSAENKCPAGPAGPKGLPGLDGLDGLPGKDGVPGEDATDIEQSPPQGCFNCPAGAPGAPGVPGPQGVRGMRGARGQPGFPGIDGVPGTPGECGPVGAPGQDGKPGAPGDKGKDGEKPISRKGLRGPQGEMGEMGPEGDQGPEGAPGAPGAPGVPGIKGFTGATGADGPEGAPGQPGKPGPDANYCPCPSRSDAQSAGVGSYKKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C773</accession>
    <name>A0A0N5C773_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC_transp_aux domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C773"/>
    <dbReference type="STRING" id="174720.A0A0N5C773"/>
    <dbReference type="WBParaSite" id="SPAL_0001378700.1">
        <property type="protein sequence ID" value="SPAL_0001378700.1"/>
        <property type="gene ID" value="SPAL_0001378700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="273"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="367"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001378700.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53325" checksum="00C3C354C5D63600" modified="2015-12-09" version="1">MFLEKENLHSSSNNTVIFDTSKGQIFNIHSGFRNIVKRLKKDYNVINNSDQLTESTFQNCKLFIISSPNEKFTEAEFGALRDYIKNGGNLLVLFGEGGESKNDTNINFLLEEFDIGCNPDTVIRTVFFKYFDPKEALIQDGVLNRSIGEMCEKSSKAINDSNSSQALSFVYPYGCTLTIGSNSSGILSTGNVCFPINRPICAFTNPSKDVVEGRIAVIGSTHIFHDNYIDKEDNMKLFDVVIKYLIDGFELNKLDSRNPDISEMIQLPDHVNLSSQLKMCLQEGDIDNTIPTDINTLFNQSIKNISLSMWPAAIRAYDKLNLKHEPLTVIVPKFEIPLPQLQPAVFSPNFKELSPPNLELFDLDEAFSSTDVRLAQTTNRYLNMPTTTDTELDNYIQEIGVILGINKNLSSNDRNSKRILEIVLHHICEFKKADQHDDHDFNASNIYADDEEEEVEYSIDDLQEYDEFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C775</accession>
    <name>A0A0N5C775_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C775"/>
    <dbReference type="STRING" id="174720.A0A0N5C775"/>
    <dbReference type="WBParaSite" id="SPAL_0001378900.1">
        <property type="protein sequence ID" value="SPAL_0001378900.1"/>
        <property type="gene ID" value="SPAL_0001378900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="26"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001378900.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35592" checksum="ADFC9498A40E8270" modified="2015-12-09" version="1">MRSYFYRKFFRQDMASPQIIVVGSIITDLISYTDVFPKPGESKRGSNFKFNCGGKGANQAVSAAKLGSNVKMIACIGDDIFGKENVIKIKESGVNVDGVLICKENRTGVASIMIDKNGENITVVNLGANLLMNVDKIRQIEDEIRKSSLVMLQNGISREGILECMRIAQRNNVQVLYNGAPGIRDLDQEYLQLTDYFVVNENEAECLSPVPLTSDNDFIMCAMKLIKIVKKAVIITRGSKSTIVAIKDGNIECCQIMNDKVKAIDTNGAGDCFCGAFAHAIITNKFTIKDGVFFASKAAALSVQKTGTQTSYPTIDEVNQILQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7K9</accession>
    <name>A0A0N5C7K9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCR1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7K9"/>
    <dbReference type="STRING" id="174720.A0A0N5C7K9"/>
    <dbReference type="WBParaSite" id="SPAL_0001392200.1">
        <property type="protein sequence ID" value="SPAL_0001392200.1"/>
        <property type="gene ID" value="SPAL_0001392200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745:SF1">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001392200.1"/>
        </source>
    </evidence>
    <sequence length="910" mass="100415" checksum="F0E3CD000E826058" modified="2015-12-09" version="1">MNFNSEVVTEDRKIVEKSVDITCKNKVSDETIHNCSSTSHINITNLIHNDNFSDVKSHPNEYSENMLESYPENINRTVTKNEVVTEISNAQNEGNELRNNQIPSQTHKGRWECVDITENEGNDESEFPHINEKLFNGEDLCDTTKVSGKQGSVEKINDLNSKSIPIIKNNQNNIANNQNSTINSINDSSTSSTNSPLPGSSNQNVKKFKNILNHLPLTISSNNVIPPVSSASTTPTHIVTNSFQIPNQQFQGNQNINNIVPAPTVGVVTKSSNSGTMEDNSNFSNLNNGDRMRLVNNSSSSLGNNVISVNKTNSTNSTSSNGQNSKKTSIASVTSNENTSNANTKTTGSNAGMNTIFGFFEKNGDNDGNIMFNNDSNDKGDDLIGSKINQAMDLVKFHLSRSIRLEYDQLNAQIAELKNKVQVLECQNNILKSFAPEDIVQNLNVLSKTNTSNTTTGTAGSTSTSSTNNVGTIVNTENGGLSRNSSTNNFMTSPNYNTKQTTEINNKELNGIYKTISDQQTNTLSHCPSVNPSICTPSPPNGTNNIGITNYTTNNNGGILLNDEQRQIQSSEECITSSPNNANDVRRKISGSNEASSSSVGIRSISSLQDNNSCNVNEGILLVNQEKKVDNINMNQYMGENGKDISTQTEKKVEPRQKEHFIVENEQNISKEENCSIFSNNNLVEKGKNINKDFSVLPNAINHNNIPENIKSETPLSYVPLEQVKNISNEVEKDRHTNDCEGKTLSSIKNSDSFEKKISSNGPLAKSQSQSNIEKNKDKSQVQTRKLSKQLALLLNQNETTCNEQISTIEHQNQQKNFLDKTNTKTMRELKKNDPEKEYQEKVKNNIISKDNISLDYIENEQSSHQQDVVSSQGLRQYQSCSQNGKTKSINKNTTNSNASKIMMVQSPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7M6</accession>
    <name>A0A0N5C7M6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7M6"/>
    <dbReference type="WBParaSite" id="SPAL_0001393800.1">
        <property type="protein sequence ID" value="SPAL_0001393800.1"/>
        <property type="gene ID" value="SPAL_0001393800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001393800.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8617" checksum="EC5E77D2EC3A633E" modified="2015-12-09" version="1">MMEEKFSDVLHGDLVARYKKVQDNKLLKTCIFLDPETSYSLLVSDENYLSETEKIVGLKDLVSGTDENGTIIECDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7S6</accession>
    <name>A0A0N5C7S6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7S6"/>
    <dbReference type="STRING" id="174720.A0A0N5C7S6"/>
    <dbReference type="WBParaSite" id="SPAL_0001398700.1">
        <property type="protein sequence ID" value="SPAL_0001398700.1"/>
        <property type="gene ID" value="SPAL_0001398700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001398700.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28552" checksum="325294278FB14229" modified="2015-12-09" version="1">MSEESDKPSMSGTAETSQKKGPKKFDISSFQERLEKLHAKRMEIEKKNLDAVVEEDRLKKQPTKETAKRKREAQVVKKVEDELVAEELGVDYDRYKSYTTSAIYADKIEEINKKKKKFTDTGFSNYEDASMKSYLRAAEAIKPDFDNYNKMKEMIGEDNFYPTANTIIDGTYYPSQSGLEKLSQSIDQREKKRREYHRRRTFDPDAVVDYINEKNRKYNEKLERYYGQYTKDIKDSLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C903</accession>
    <name>A0A0N5C903_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C903"/>
    <dbReference type="STRING" id="174720.A0A0N5C903"/>
    <dbReference type="WBParaSite" id="SPAL_0001438600.1">
        <property type="protein sequence ID" value="SPAL_0001438600.1"/>
        <property type="gene ID" value="SPAL_0001438600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.519.10:FF:000014">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000232">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001438600.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50135" checksum="C57A13AC28655F84" modified="2015-12-09" version="1">MNDEYDAIVLGTGLKECILSGMLSVSGKKVLHIDRNNYYGGESASLSPLNQLYEIFHGKDAQAPEFMGRGRDWNVDLIPKFLMANGQLVKLLIHTGVTRYLEFKSIEGSYVYKGGKVYKVPADEVEALSTSLMGMFEKRRFKKFLVWVQGFDINDQDTYEGMDPTKDTMQQVYDKFGLDENTADFTGHALALYRDDAYKNELFVKTVQKIRLYSDSLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLDKQVDEIVIENNKVVGVKSGNEIAKCKQLYCDPSYVLDRCKQNSQVVRAICILDHPIPDTKEAASCQIIIPQKQVNRGSDIYISCVSNANQTAPKGWYIAMVSTTVETGNPELEIQPGLQLLGQIKEKFIRVYDIYEPVDMGHESQIFISRGYDATTHFETVCTDVLDIFARGTGEQFDFSKITHLTMEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C982</accession>
    <name>A0A0N5C982_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C982"/>
    <dbReference type="STRING" id="174720.A0A0N5C982"/>
    <dbReference type="WBParaSite" id="SPAL_0001446500.1">
        <property type="protein sequence ID" value="SPAL_0001446500.1"/>
        <property type="gene ID" value="SPAL_0001446500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="377"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="777"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001446500.1"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125904" checksum="7166D11F0D22AA90" modified="2015-12-09" version="1">MAEMYYQGGVGNTGSKGFSPGPYGYPMLGCNISRNFQDITEDERKCLEQRKYWCFLLSSIVTFCVSMFFVVIWRVVAHLFFRRPDREALEPIPVDEEVNETLKGIVNNKELERLNMKEEQVQLGWVTEAKDWAGELISGQSMTGRILVVLVFVLSVGSLGIYFYDTSHPNFQVETCVSWLESPSQQIDLGFNIFFLIYFFIRFIAASDKVWFLLEVYSFVDYLTIPPSFVAIYLERNWLGLRFCRALRLMTIPDILQYLNVLKTSSSIRLTQLLSIFISVCLTGAGVIHVLENSGDPFKNFVNTHRITYWDCVYFLLVTMSTVGYGDIYCTTILGRIFMVFFILGGLAMFASYVPEIADLIGSRQKYGGEYKGEHGKKHIVVCGYITYESVSHFLQDFLHEDREDVDVEVVFLHRVPPDLELEGLFKRHFTKVEFFTGTVMDSIDLSRVKVDEADACLVLANKYSSDPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWRRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPHTPSWLNDYLRGAGMEMYTETLSHAYVGMGFQEASDLLFTRLGLLLLAIELKDDEKKECNIAINPGPGTIIQPQTQGFFIAQSADEVKRAFYWCKQCHADIIDASLIKKCKCRNFTLFRKGARQVQLAKKVGKNMVNVTDTPRPGMAINSGKPLIDLMMSKGPKYTIYDQTSSPDIRDIDITREFEQQDMKYDSTGMFHWCPPRPIEECILDRHQAAMTVLNGHVVVCLFADKDSPLIGLRNFVMPLRASNFHYHELKHVVIVGDVEYLKREWKTLHNLPKISILNGSPLSRADLRAVNINLCDMCVIISARIPNPNEDPTLADKESILASLNIKAMQFDDTLGFGHARITNGSVSPLGSPISIHRKGVRFGTSVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTQETLANRDRCRISQIALADQPYEGIGTASTYGQMFSLALKRYGQLCIGLDQASPDSNKRYVITNPPAELRLLSSDNVYVLEQFDPGLEYEPGKQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9F5</accession>
    <name>A0A0N5C9F5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9F5"/>
    <dbReference type="STRING" id="174720.A0A0N5C9F5"/>
    <dbReference type="WBParaSite" id="SPAL_0001453800.1">
        <property type="protein sequence ID" value="SPAL_0001453800.1"/>
        <property type="gene ID" value="SPAL_0001453800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="83"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001453800.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="62538" checksum="E80FE07EEACC1240" modified="2015-12-09" version="1">MLRIISRVVQEQHVSIRNKFTYSGLTSTDFMKKPLNEPVLTYKKCSKERIELEKALKELSGTVTDVPLLIGSKELKGKLDQTQIMPSDKNTVIARYSYATPENINEAIELALSVREKWALKSLRERAEIFLEAADLCAGKYRMKLNASTMLGQGKTIVQAEIDAACELIDFLRFNAYFALDLEKYIPISTNISKNEMIYRPMEGFVASIAPFNFTAIGGNLASAPALAGNVVIFKPSNTAVLSNYFIMKAFEEAGLPKGVISFLPSDGPIFGNTVTDHSHLAAINFTGSVPTFVHLWKQVGEKLGKGKYITFPKLVGECGGKNFHFVHPSADLQSVVTGTILSAFEYSGQKCSACSRLYLPKSLWSQFQVEFGKVLKELKVGDVREGDSFTSSVIDKIAFDRIKRYIDLAKSNEDGSEIVFGGGYDDSKGFFIQPTLVKVTSPKSKIFREEIFGPVVSVYIYPDNEVDTVLGNVKNDTPYGLTGAVFSKDEVFLKKAAIVLRDAVGNLYLNDKSTGSIVGQQPFGGARMSGTNDKAGGPHYFLKWTSPQTIKTTSVPLTSWKYPSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9Y7</accession>
    <name>A0A0N5C9Y7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Tyrosine aminotransferase</fullName>
            <shortName evidence="12">TAT</shortName>
            <ecNumber evidence="5 12">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5 12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9Y7"/>
    <dbReference type="STRING" id="174720.A0A0N5C9Y7"/>
    <dbReference type="WBParaSite" id="SPAL_0001471400.1">
        <property type="protein sequence ID" value="SPAL_0001471400.1"/>
        <property type="gene ID" value="SPAL_0001471400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="74"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001471400.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="48867" checksum="138D3449C0A5E64B" modified="2015-12-09" version="1">MGKLEAPVLNATTCDKIIGEKGKSLPVPTPTQPDQLINRWAPLKPSIFAQNTVNPVRLFVEALAIQPNPKLTPIKLNLGDPTLIGNLPPPQAAIEGVQEALLSGKFHGYGPSVGFPESRQAVVDAFNHPEAPITLNDVILTSGCSHALQIAIESIANKGDNILVPKPGFPLYTTLMTPLGIEDRSYNLILGGTEKIDFNHMESIIDKRTKAIIINNPSNPIGIVLEENDLKKILEIAYKYRIVIIADEIYGDLTFNGAAFKNIATLTPKVPVISCDGIAKRYMVPGWRLGWIIIHDRFGVLEHVRKGMISLTQKIVGPCALMQGALPKILKETPKNYFEECRKTIEDNTKVFFEGFNEIPGLTPIMSNGAMYMMVKIDPYIYGNDIEFLKDLIQEQSVYCLPGGAFGTPFWFRVVLTYPESLSKEAIKRIGEFCKNRRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAE4</accession>
    <name>A0A0N5CAE4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAE4"/>
    <dbReference type="STRING" id="174720.A0A0N5CAE4"/>
    <dbReference type="WBParaSite" id="SPAL_0001486600.1">
        <property type="protein sequence ID" value="SPAL_0001486600.1"/>
        <property type="gene ID" value="SPAL_0001486600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001486600.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12291" checksum="CD93C8F732D0F7EF" modified="2015-12-09" version="1">MCCCKVISNSTVDADIFSEYLEELCMYIRDEMKLQAACLILDNARIHKRNEIERITSMFNFDFKFLSPYSYMLNPIENAFSKIKNCVRSRLRNNENGVLSDIIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CB25</accession>
    <name>A0A0N5CB25_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial translocator assembly and maintenance protein 41 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CB25"/>
    <dbReference type="STRING" id="174720.A0A0N5CB25"/>
    <dbReference type="WBParaSite" id="SPAL_0001508900.1">
        <property type="protein sequence ID" value="SPAL_0001508900.1"/>
        <property type="gene ID" value="SPAL_0001508900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001508900.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12739" checksum="65F1916363F02BCE" modified="2015-12-09" version="1">MLVITFFYVGWGSEKVTNIQANYGAHVYYNIVVKSNRRMIKYGVISTYDTLQHLLDWRWLYVSGRLQKPVLNVLSPTKKLTEAIENNRNTALRFALLKLGDTFTFEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC36</accession>
    <name>A0A0N5CC36_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC36"/>
    <dbReference type="STRING" id="174720.A0A0N5CC36"/>
    <dbReference type="WBParaSite" id="SPAL_0001544500.1">
        <property type="protein sequence ID" value="SPAL_0001544500.1"/>
        <property type="gene ID" value="SPAL_0001544500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001544500.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39656" checksum="F123E23C2B156942" modified="2015-12-09" version="1">MEDTDVSRRLKEDVIDDINNNHRKMVPFSECRYENFAVRKHFDADSKRIKSMDISPCGDFLATSTGSEKIILFDVPSGCEVGRIPTKKYGCSHVVFAGDGLKALHSSEKINDDIRYLCLEKKKYIRYFSGHKDDVLSLSMSPDGQTFLSSSRDGAVKMWDFRSDETCMTSTYFHLNPRVAYDPKGTIYAVSDEKNLIKFYDSRYINRRPFKVMSSRSSTWNVNNIRFSLDGRSILASADGNYFYTFDTFTGEKMSFGGISNCRRLNFGVDFSPCGRYIIAGSDFGELLYYDAVKGRLLKTFKSPHSGHVENVLFHRKYLMLVTGVDDLIFWTPDYDGDEVFDWVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCU2</accession>
    <name>A0A0N5CCU2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCU2"/>
    <dbReference type="STRING" id="174720.A0A0N5CCU2"/>
    <dbReference type="WBParaSite" id="SPAL_0001569200.1">
        <property type="protein sequence ID" value="SPAL_0001569200.1"/>
        <property type="gene ID" value="SPAL_0001569200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001569200.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20339" checksum="62BE1E4E9F237808" modified="2015-12-09" version="1">MTSPLENCNLEEQRLVTKFLVLERLSPLKSILVCLSNVIEGTIHSVIQNKLNNRKKGVKRLDYEIVPHPPYSSDFAPSDFYLFGYEIVPHPPYSSDFAPSDFYLFGPLKDSLRGVKFNNNGEIKEEIQKWLRSEDKNFFATGIRKLVERWDKCINVADDYVEKRVKFGIFTIINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDH5</accession>
    <name>A0A0N5CDH5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDH5"/>
    <dbReference type="WBParaSite" id="SPAL_0001591900.1">
        <property type="protein sequence ID" value="SPAL_0001591900.1"/>
        <property type="gene ID" value="SPAL_0001591900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001591900.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20613" checksum="3263A61B66011609" modified="2015-12-09" version="1">MKSKDGISTIEKINKYRESKQFPSKNELFWDVKQQEESDDEAPEEMSFQGFTKKSNLKMTKMSSKAKKALKEEKISKESSEDGEKVDEKVNDEPETLEDDIEDGNDDLLGAYSETESDGYSETNKETVTETIIRPKVPFNFKSSLLLRKRKEDDLYLDRQKQNYYFKKQKFSNTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDY8</accession>
    <name>A0A0N5CDY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDY8"/>
    <dbReference type="WBParaSite" id="SPAL_0001607725.1">
        <property type="protein sequence ID" value="SPAL_0001607725.1"/>
        <property type="gene ID" value="SPAL_0001607725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001607725.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="16173" checksum="E3C197B646C69785" modified="2015-12-09" version="1">MGAKNLPMIFQRQMEKIFENVVKYEPKSRFLICQDDLLFITQRREKHLQMLERILDTLGQKNCKLISEDVNYLERGIHFSHENLMEYQLTKTKGFLYTTFQAYNYFRIAISDYTNRTYDFYKLSRRNYYMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CED0</accession>
    <name>A0A0N5CED0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COX6C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CED0"/>
    <dbReference type="WBParaSite" id="SPAL_0001622000.1">
        <property type="protein sequence ID" value="SPAL_0001622000.1"/>
        <property type="gene ID" value="SPAL_0001622000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001622000.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13650" checksum="F6BC7CCEA6C8167A" modified="2015-12-09" version="1">MDDKISQRFISEEFRKTTEHSSSKSKLLYYLDIRKRSFLGKLGVGLAAYLVCFNAAVFYWKGSDHPLNNFMWRIKKANGTLSKELLEKERVLKEYYESRLNVESKGPKPWLTSIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF50</accession>
    <name>A0A0N5CF50_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vesicle transport protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF50"/>
    <dbReference type="WBParaSite" id="SPAL_0001648700.1">
        <property type="protein sequence ID" value="SPAL_0001648700.1"/>
        <property type="gene ID" value="SPAL_0001648700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001648700.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32385" checksum="9590078EE641E8E5" modified="2015-12-09" version="1">MEELRFSKRQLDPINRIVDGVDQGAEVIRRKARSLSREAERAVEKIQNISNESQSLVTQFQTILLDEPIELAPKNVKELKIIYMRIFYSILSMLFGQKISAYVIFKIFNQLIDTESSILLSYIIIPVIIILKYFPTKDKNEEKEKLEERNLYIYSIFIGMALGFVFIRLQTDTTISYGILNASVLFSYFNLPNFVLSVGDKRKNQVIVSVLPSLAMIFIGYILKESLVTAFLASLFYCCINFISFQVYTNYTTCNVKSTPTALIIINIILEIYLKTVLASIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGP3</accession>
    <name>A0A0N5CGP3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGP3"/>
    <dbReference type="STRING" id="174720.A0A0N5CGP3"/>
    <dbReference type="WBParaSite" id="SPAL_0001701900.1">
        <property type="protein sequence ID" value="SPAL_0001701900.1"/>
        <property type="gene ID" value="SPAL_0001701900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="210"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001701900.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35714" checksum="414EB0B06D954A7F" modified="2015-12-09" version="1">MAEFSRICGGDSSIRPHSSGVTGCIPVNHSNVCYQWTINNFFEILHSRKMKLELESHSFSVLGYPNVVFKMCMLLHAESPGGNSYWGLFLKASSASSKEELNINIPHMFKLTSPTRDKVFWNSSSLEGVFYSEKLTQFQCGIESRITLKTIKETLFSTGALNVICETMHKGNGERFMGQNNKNDELKTKISHYERYLNRLSTMYASQYASDFKIIFCGKKGFSKIYKVHKSIFMAHSLYFRSLLTDTNTTRSKCNSVAIGEEVGFPAVEMMIEYFYKAKIPSDASHEDIKELLHLANAYEINDLKLLCEGMLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CGQ6</accession>
    <name>A0A0N5CGQ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell division cycle 5-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CGQ6"/>
    <dbReference type="STRING" id="174720.A0A0N5CGQ6"/>
    <dbReference type="WBParaSite" id="SPAL_0001703200.1">
        <property type="protein sequence ID" value="SPAL_0001703200.1"/>
        <property type="gene ID" value="SPAL_0001703200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="672"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001703200.1"/>
        </source>
    </evidence>
    <sequence length="736" mass="84192" checksum="A3B4C9AC492AEB63" modified="2015-12-09" version="1">MVKVIIKGGVWKNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWEEWLDPRIKKTEWSREEDEKLLHLAKIMPTQWRTIAPMVGRTAAQCLERYDELLDEAQRKAEGIEDDVEAKDAKKLKAGEIDPAPESRPARPDPIDMDEDELEMLSEARARLANTKGKKAKRKAREKQLSEARRLSALQRKRELRAAGIDVGDPNYKAKKKGDFIDYNAAIPFQIPVPAGFHDPEEDTFNKSECVNKYTSAEPVPDENKLRREDKKKLQKRKQEEMPETIFKRPDEIKRSKLILPTPQVTDKEIEEIVKLGKVNQMAKGMIDDSASSTLLHDYEESTRVTFNTRSVRTPAVHDDHISKEVETIIALQNTESTLKGGINTPLNDLNLKSALPEHQVPATPNVILQALAGTPIHNNVTGSVRVAQTPAGFTPGPTPFRDQLNLNKDGENLEGEDFDWKSAIASLPKPKNEFEIVLPDEDEVEDDVGGDVQMKDGEEDEEVANEKRRKFIEKKEKELLRRRSTVYQRGLAIPVKVNNALFKKPYDRSDYGKAMKLISKEMKNLVEWDVTNTPSNDIDTSITPEMIEEAKKLIDAEITEKPEYDEEMASAMDLCYSELVPYEGKLTRIANLNRKDQMDCLVKELDVIDGWLQKLGGGVSKIDKKLQVKMTGYFKVAEKLIKKIEEKRHERESVQLQIDAFSRLYQHELMSIKRRVGKLQTEVDSLLRRENELQKEYAQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CH99</accession>
    <name>A0A0N5CH99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CH99"/>
    <dbReference type="WBParaSite" id="SPAL_0001721800.1">
        <property type="protein sequence ID" value="SPAL_0001721800.1"/>
        <property type="gene ID" value="SPAL_0001721800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="212"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001721800.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="53907" checksum="A937CB9471417B45" modified="2015-12-09" version="1">MTAPEFFCEEDYGSKYFIGGKITHQWIVDCLEKNDADFRKHKGDSKVKEINGIDISDGKGFTSKVFKTSIYFDDEKKAPYYVILKIPGDESFKESMKKQNIDDTLNMELDKISPFHNKECHFYNYVASKIKDLKYPECYGSKDIIVGKQTGALIMKFLGSDSVTVPFYRSLNIYQTKSVLDEAFKLQEYSLLNQDDFISNSWEQPFSEEIMKSFLDYIKKGMPTVKKYIPKEMWSEIEDDLDKMVSNYTKIIKHVFIELPYIPKEMWSEIEDDLDKMVSNYTKIIKHVNLELPKSNGNVTVISHGDMWTNNFMFKLDSNGNCSNDLSAVFDWQTVFKGTTGHDISRILAVSAPPDVRREIEKEYLPDFYERLKESLIKSGKEMKISYETFMNNYKLCFIEQSLMMFLMIGFALQEYNVPEEPDYIWDARKFNIGSKVWYNIYDAIKFCKELHPEWLENSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHU8</accession>
    <name>A0A0N5CHU8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHU8"/>
    <dbReference type="WBParaSite" id="SPAL_0001741000.1">
        <property type="protein sequence ID" value="SPAL_0001741000.1"/>
        <property type="gene ID" value="SPAL_0001741000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052854">
        <property type="entry name" value="Serpentine_rcpt_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518:SF9">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001741000.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39163" checksum="E0EE13B338D17EAB" modified="2015-12-09" version="1">MLLIPMMIGVILCIAAEILLFILLPFMIKFAYTRRSWHLYYKITFLMLLLTITAYALSTCLVDITLLCLNGILQPKYVKLEEKLFYIGYQAQIYTSAFIRSCNWVLVIERTTSTLKRKVYERYRSTAVAISICIVIISYGIIVNNISRIWESFEGHYYKFSIGFDFFTIIISCYLWYKNVKLRRLTIISDINLSEKFQLNENIRLVKFTFPFIAPYILINTGFNLLLDFGQSLLSDTNLILAYNDLCIFISYIIVFIYVLNKNNIIKCLSHRNTNGISSFNRTFKKNESSQKNGIKKLDTTTKQFKTNSQTLQINGKHIPTNYDGDAYQKIVTKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIC4</accession>
    <name>A0A0N5CIC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5CIC4"/>
    <dbReference type="WBParaSite" id="SPAL_0001757800.1">
        <property type="protein sequence ID" value="SPAL_0001757800.1"/>
        <property type="gene ID" value="SPAL_0001757800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001757800.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61166" checksum="A2268A73B44732E0" modified="2015-12-09" version="1">XFYYNFGDCNIPDLINTFSGFINCITTCLPTTTPPPSTTRCPEGTKVCYSNVRIYVDSSNDILYPPLFTQEQSLLTNNITNIIPHDFSQLAVLSQNKLFQNQEYGFGSISGRQQFIDTIRLLQQGPGYMLSEILSSLYNTIPRNSYPTSTFVFLSDKTKIDLSNSYQVAQNLKSNGNTLYFILLGTAIKMEDVAPLMATNTTIWQFSDCGEQFILDFFNDGFICSYECGTTTTSTTTTTPTTTPCIDGQTQCNIVIGMDTSYDILIPTLYQSTLDVIQQNISGQILDFSKVALVAYDYDVHEFHDFGSIQDRNQFNNIIGNYRQHAGSNLKNLLQFLDNIPNYGQMTYIVFISENQAFDYDVYLLSHNLKNKGSLQFVILGTDINPSELSHLSSSDAFYYNFGDCNIPDLINTFSGFINCITTCLSTTTPPPSTTRCPEGTKVCYSNVRIYVDSSNDILYPPLFTQEQSLLTNNITNIIPHDFSQLAVLSQNKLFQNQEYGFGSISGRQQFIDTIRLLQQGPGYMLSEILNSLYNTIPRNSYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIF4</accession>
    <name>A0A0N5CIF4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIF4"/>
    <dbReference type="WBParaSite" id="SPAL_0001761000.1">
        <property type="protein sequence ID" value="SPAL_0001761000.1"/>
        <property type="gene ID" value="SPAL_0001761000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001761000.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20248" checksum="E7C3B1E80D6C164E" modified="2015-12-09" version="1">MMTKFLYLHENEYIKVEDVYIPIENNEPRLQEMENLLLKMDLKNVMYFEIVVTGETIIFDVLDRYFKYGTTVESLQINIQKCPSFEGFSRFIRKIRYVTYLWLNKLCFLSQPIPVDFTLPMIDNLNNLCLVECECTKFVNPKMITNLNCNNKNLKRILVFLTVRTWNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2G9</accession>
    <name>A0A0N5B2G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2G9"/>
    <dbReference type="WBParaSite" id="SPAL_0000027600.1">
        <property type="protein sequence ID" value="SPAL_0000027600.1"/>
        <property type="gene ID" value="SPAL_0000027600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000027600.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14507" checksum="DDD2454CF31BB282" modified="2015-12-09" version="1">MLKSINEEHVVEDGYKSDDFFDVPHMIRKSSSVGSMPRKWLFADLEKQQKKVCKTSIVMPNEKIQDKEEKSNKLLYINFFMVILTLLCLAMTLMFLMTAAKNFNSSLSKTLSDAMMSDIMEKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2T0</accession>
    <name>A0A0N5B2T0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2T0"/>
    <dbReference type="STRING" id="174720.A0A0N5B2T0"/>
    <dbReference type="WBParaSite" id="SPAL_0000038300.1">
        <property type="protein sequence ID" value="SPAL_0000038300.1"/>
        <property type="gene ID" value="SPAL_0000038300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF25">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893907" evidence="6">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000038300.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18198" checksum="2C301000B135F0D0" modified="2015-12-09" version="1">MIFFVVTYLLLFTTILNACTCRLKSIQDIICSSDWVSHLTILGKYDTIAIDTNVEGPQIAGNLMYITLHKEIFKVADNETEIEPIIFTAKNEVVCGMPDLVVGKEYLLAGYYTGDINRIRLCDQMSPEKNPRFLFPPEWYQIPEDIKDKLRKDFYKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3K5</accession>
    <name>A0A0N5B3K5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3K5"/>
    <dbReference type="STRING" id="174720.A0A0N5B3K5"/>
    <dbReference type="WBParaSite" id="SPAL_0000065900.1">
        <property type="protein sequence ID" value="SPAL_0000065900.1"/>
        <property type="gene ID" value="SPAL_0000065900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="277"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000065900.1"/>
        </source>
    </evidence>
    <sequence length="617" mass="70461" checksum="3E0A2BB0A6B0CDBE" modified="2015-12-09" version="1">MKTCKELVLYKFRYHDLKDCLYRTFFSTSGDRRTLQQRLMHLLENEATRWRVRKAILERGVNMNYCPSTVLETISRGPAALNNSKAKNDDIATEINVVMKKFYFYKNVKKLTEWNVVSSKDISAYLVFGFLLPTELRNSILSSKECLILRCAKISEVDNLPHKDCYPHGMKLFINSREFTDLLPRKIIYNDVFEEGRLNVPTNISEAFITLFKDNRTKGFLRIEIRFNGAANTGSTFAYSVFSSAPKTVEELVSEITNKPKISVEEFGTDLEKCLSGGDGLILESIKISLNSSISRERIKIPFRGKNCNHISPDDLETYIRINEATESWLCRNCKHPCTPDDIRVDEFFTKVLQNHPNIEEIELFPGAEYKIAGCRGKLNVNNSKDIGDKEKNDDNMVVLLSDDEMDDEIDNSFLESLSSFENNDGENTGEQSLLNTNPNIDPIECILIEDSSDDESTIETSEQREFIVCSREFPTEKPNNEPSRERTRVVDRMASGETDNNDLLPPPPPPPSESEILASLKGANFSVSTTVNVSIPYFQQTSIFKQESVDAIKDRVAKNCPVIIELIKGFITQSNFYEMYVTTKPEDFKIWKPVNISNELWEVLTMPQVHSLFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3X9</accession>
    <name>A0A0N5B3X9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type POZ protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3X9"/>
    <dbReference type="STRING" id="174720.A0A0N5B3X9"/>
    <dbReference type="WBParaSite" id="SPAL_0000078100.1">
        <property type="protein sequence ID" value="SPAL_0000078100.1"/>
        <property type="gene ID" value="SPAL_0000078100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="192"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000078100.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41311" checksum="32F8CB603272A35E" modified="2015-12-09" version="1">MVLKSSKSVDDSCNTHSIVNKFNYTFSIENFSHHLEKTGEKIISPTFVVGWRNKSEWCLWIYPNGDKEESKEYVSVYLRLLKPEKAKAKFRFSILNDKEEEKNVYRSEMIKEFVKDKGSSSWGFHKFVNRDFLLNESNDLLINNKLTIFCEAEISEPRSENHDNSETSINITIPQSKLVSNYCNMFESSLFTDCIIRVEGTEIKAHKAVLAAQSSVFYEVFCNSKEETQTDVVEIKDFRPEVVREMLRYIYTENVSNIQNIAGDVLAIADRYKLDRLKAISERSLCYSLDIMNVCERFALSEKYSTGTLQECCQELILENAAWLAKTKEWKKFVLVRPLLLESLFLKSLNTSSVGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4J6</accession>
    <name>A0A0N5B4J6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VASP_tetra domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4J6"/>
    <dbReference type="WBParaSite" id="SPAL_0000099700.1">
        <property type="protein sequence ID" value="SPAL_0000099700.1"/>
        <property type="gene ID" value="SPAL_0000099700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000099700.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7983" checksum="34F909157FE07895" modified="2015-12-09" version="1">MERLLMDKIVELEDIIRKMSSNNRGTSPNTKEADNANLSTSTDSTRGVSDNSYIRSDDNVIEEDCNENSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5L7</accession>
    <name>A0A0N5B5L7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B5L7"/>
    <dbReference type="WBParaSite" id="SPAL_0000136100.1">
        <property type="protein sequence ID" value="SPAL_0000136100.1"/>
        <property type="gene ID" value="SPAL_0000136100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="345"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="851"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000136100.1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="128431" checksum="2CC41DCDE4C7C4A2" modified="2015-12-09" version="1">XDMKLNERSSKFEEDLGYLCSLVRKTMPKCTDKQRLEEMKRRIHTKLTPHSDLWKFVIMSSYDNESDLVREVASYAKLLAPPQIPKDKVSKSSPVKEKSKGSCSIHPKGTHSDAECQKEVEKFPSQNFILKQNSNSRKADIRIPLSFMDSQQEREISAVGYVDSGAQVSIMSAKLARRLKLEVQPSKYKSLKGFTQHCKETSGSVNVILCLSDHQLQCNFEILEQVPDMLSEAFIGNDILALVEASVIYKEPRGIQIEDTFIPSICPLERKSKEPIMSRIEANDLSVKALITEKHPNVISTGKWDIGKCIHSAPPFQLSSPEIPKFKRYSPPISTHLELESYVQSMLQAGVCKKNYEAKHVFNLVCAYQPGRDLRVCIDVRPLNEVLISDHYTTKPIKEFMRELAQITYVSSIDLVKSYFQIPLDPLDESLIGFRTNSGIYSMLRLPFGAKTSPMIFQRILDRVLDGTPALSYQDDIIIPSHGTLSEHTSDLLKVIEALEKACLKINMDKSTFASTSCNFLGFHFSREGIKPTEKYISAITNFPDPSNLRQLRRFRGIYNFTRHMIQNAFILEKPINEFISLHRKDSANITIPPQVLEAVSKIKKSILKIPTLKYPDYTLPFIIHVDASSHGYGAILCQHPPDSQNLNIIGFFNKATAPLKRTLSAAHLEIRGLSAALSYFKEYILGYPIEVYSDHKNIAAMVASNSDPRLFKFIANIMTFSPTIRWIKGRKNEAADALSRAFMFSDAQDILDSQNTPTSPTTNTPNQIKLGGIIGSKINSHFKPHVPEEEIPILAEKIHRQGHYAEEKCIEFVERFYTINKNKFKKHLKEIIDNCMPCKAHNINNIDRNIHQRPVIVLWPRAVYSVDVCGPFPLSLSENRAKYILLAVDSGTKYWMTTTLNSINTSEISIKLRDDILFKFGLPEVLKTDSAAYWSSNEFSHFIKDLGIRHRLGTPYNHKSSSLAERSFRSIEELIAKNVGPLNWDSYLPYICFIYNHWPQKQLLSRTPAELFLADMSIPQFESESLVDCLSSQQNTEQLRILELLHEIALNKWSKFPNDETVCKTGDKILVRTISRENKFMPRYNGPYTVISATPYMTQYRKSEKSRKVSRAHPQHVKLFEVQGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6A0</accession>
    <name>A0A0N5B6A0_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6A0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6A0"/>
    <dbReference type="WBParaSite" id="SPAL_0000158900.1">
        <property type="protein sequence ID" value="SPAL_0000158900.1"/>
        <property type="gene ID" value="SPAL_0000158900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF69">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000158900.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25669" checksum="9A0962F322B3EAFA" modified="2015-12-09" version="1">MVDNNSDVATAKQSQEVKLPAEVSISNGKHKLTSRWCLWYLKGDRNKEWEDCLKMVSTFDTVEDFWALYHHIQLASGLNWGSDYYLFKEGIKPMWEDANNVKGGRWLVVVDKSKRAAKLDHYWIELMMAIIGEQFENYGPYICGAVVNIRQKGDKVSLWTRDASRDDINLRIGQILKEKLEIPDNESIRYEVHKDSSNKTGSMVKPRIVLPEKLSSRQDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6D3</accession>
    <name>A0A0N5B6D3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2 NT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6D3"/>
    <dbReference type="STRING" id="174720.A0A0N5B6D3"/>
    <dbReference type="WBParaSite" id="SPAL_0000162300.1">
        <property type="protein sequence ID" value="SPAL_0000162300.1"/>
        <property type="gene ID" value="SPAL_0000162300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="477"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000162300.1"/>
        </source>
    </evidence>
    <sequence length="882" mass="100444" checksum="823B9182314F7411" modified="2015-12-09" version="1">MADLSLSSSQFKMRMFANWESDRSSSSTVQRVFLLSINRLTLNSISADLANTLVITFKLRNGKRSLRTNDINIPQTQNDKITIDLDLSVTIQYPHFLKKVNTLHILIQRRKKYGKRKIPGFKNIAVGKLNLTDVLQNGSLKEITLWLMNDYDKSENLNYEYLTPFGVLSITNCYSQSAPSQFIEKSKNDELGTLSEEDDDQDSSQEDATNIRDDYIRNNLYHNIHSRRNKHSRQTPSTKKLNQKNLKQKFVNLMKKLKNTDVGEPEKEGSIVMARTAQELEEWFEELENLSDSGPEFDNDRVSIISNPRPGLRPFFSSTSNIDIYPVLEKYQTNISEESAETDEPETSSDHDIGNESLTESLFKRDSDNHKSELGAKNSFTHHTPSKHHPFHAASFDMTDKTNTDKILRSSTLHSLGDQKKSSNHNISQTFDSISSVHSQTCQPSTPNKQFENQVAFTEILSKTLKLDDPSLISLRNVWLICTQDMPSLKCLHNLSSEIKILDCFSLTDTKAALHGIISKIQKFCNTNSCEPDETLIGICGSDKHISNIVRAYIDSMQNKTSNNWTNYLRFVVVAPLYSTVGRLLKPLNSDFSNLIENFWSNLSHQKINEAEEIMKLLINLNNVLKSTRDSPNSSSGEGLCFKRLNLPLGEVMLQSSTNDSVSVSRQLFIPFILQVTVGDAENMSPLYKTNSIDNAEKLVQSTNSHGNVTNLSRNTYSPPHSPSSIKNDTKELQIDYWTIPPSAAREAQASSDNYAFDRNIQPRKDLFSNSEKTTLKTNFKYLCIYRDLLSQFLNFQFVKEKKKDNVLQKFARKKGNKGDFNSYQNFLTSSITRLICHAKHSNFEVTIDGNIYTSIRFFQISSQWQTHVKFFPIALSINNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Z1</accession>
    <name>A0A0N5B6Z1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Z1"/>
    <dbReference type="WBParaSite" id="SPAL_0000182800.1">
        <property type="protein sequence ID" value="SPAL_0000182800.1"/>
        <property type="gene ID" value="SPAL_0000182800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000182800.1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7849" checksum="81E24381F41ED841" modified="2015-12-09" version="1">MGPTLNGCPVICRKYKFILDCSRFCGFNYSAVPATKKISDDNPPESLPSQPPNYIEENDITRDFYDELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7M1</accession>
    <name>A0A0N5B7M1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7M1"/>
    <dbReference type="STRING" id="174720.A0A0N5B7M1"/>
    <dbReference type="WBParaSite" id="SPAL_0000204600.1">
        <property type="protein sequence ID" value="SPAL_0000204600.1"/>
        <property type="gene ID" value="SPAL_0000204600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF13">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="2">
        <location>
            <begin position="86"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="3">
        <location>
            <begin position="307"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000204600.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52667" checksum="DC4514C523B5EAE0" modified="2015-12-09" version="1">MFNSRFLSTTFKRTFYNAQIPKGDLRVLNVPHGKFENSKYTTYDDAMRFIQNNMKLYSQAASLSPTPLWDALVKRIDSANLSGLEIQHIITMGNVPWLNENYYDKIRSNSLFLCKNIRKHVEIGKADYIPIFLSQMPQMFSQMKKKFDVSFVACSKPDRHGFVSISLSVDCTLGALRNSKHIIGLCSDQVPKIYGDSMIHASQFSALIEDNTYKPYEMPNAKLDMNGPEAKIGKIIAENLIDDGATLQLGIGAIPDFVCSYLKNHKDLGIHTELMCSGASELIESGVITGSKKHVDVGKHVTSFICGNRRFFDFVDENPNFVMKCASYTNNVEVVAKQPKMTCINSGIEIDLTGQIVSESIGTKFYSGFGGQVDFITGSGMAYDNQGKAVIAMTSRTPKGKSKIVATLTNGSGVVTTRAHVKYFVTEYGIANLFGKSARQRAYELIQISHPDDREELEKKAFERFRVMPSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8B4</accession>
    <name>A0A0N5B8B4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase HDDC2</fullName>
            <ecNumber evidence="7">3.1.3.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HD domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8B4"/>
    <dbReference type="STRING" id="174720.A0A0N5B8B4"/>
    <dbReference type="WBParaSite" id="SPAL_0000228700.1">
        <property type="protein sequence ID" value="SPAL_0000228700.1"/>
        <property type="gene ID" value="SPAL_0000228700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000035">
        <property type="entry name" value="HD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="12">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000228700.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22943" checksum="A64BADA62B644412" modified="2015-12-09" version="1">MVNSNSIDILKLGEVIGNLKHLKRTGWTKWSEIKEVETVACHMYRMAMFSMSIKELRPDLDIDRVIKICLVHDLAEALVGDITPHCGVSDLEKFNLEKEGFQEIINYLPKKTGDEWYEYWMEYEKQETAEARCVKQLDKYDMIAQAYYYEKTYNIDLSDFFNSTEKSFFEVPFIEWNNTLRNDRNEFKSRKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8C8</accession>
    <name>A0A0N5B8C8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8C8"/>
    <dbReference type="WBParaSite" id="SPAL_0000230100.1">
        <property type="protein sequence ID" value="SPAL_0000230100.1"/>
        <property type="gene ID" value="SPAL_0000230100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000230100.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9747" checksum="970370E709D1BBDA" modified="2015-12-09" version="1">MSNKFIVIFIFYLTIIISTAIAIPAINFGKLERNNIKMTSTDMPHQPAVPPVLEKDIIHPTQSLLEIANKSSTSRPHNIQTQLLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8M9</accession>
    <name>A0A0N5B8M9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8M9"/>
    <dbReference type="STRING" id="174720.A0A0N5B8M9"/>
    <dbReference type="WBParaSite" id="SPAL_0000240200.1">
        <property type="protein sequence ID" value="SPAL_0000240200.1"/>
        <property type="gene ID" value="SPAL_0000240200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000240200.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26195" checksum="852ED438A2793A28" modified="2015-12-09" version="1">MNAEKYSVSDSVLGTKEFWDSRYELEIKNFEENGDEGEIWFGKNAENRILLYINQLELDKDIQFIDIGCGNGSLLRRLQDRGYKNLTGVDYSSSAIELSKRLSDNGNDSNNEIVFKVDDMLSDNHDSELVHKFNVILDKGTWDAICLSGDREERLKCYKKSIDTFFTNDPSKVQLFIIVSCNFTKEELIELFVDDNLQFESDLPPSKTFSFGGKSGQTSTGVVFKKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S1</accession>
    <name>A0A0N5B8S1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Pyruvate carboxylase</fullName>
            <ecNumber evidence="2 8">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="2 8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S1"/>
    <dbReference type="STRING" id="174720.A0A0N5B8S1"/>
    <dbReference type="WBParaSite" id="SPAL_0000244400.1">
        <property type="protein sequence ID" value="SPAL_0000244400.1"/>
        <property type="gene ID" value="SPAL_0000244400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="16">
        <location>
            <begin position="35"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="155"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="17">
        <location>
            <begin position="562"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="1102"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="907"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="12">
        <location>
            <position position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244400.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130444" checksum="76CCE19C6D1F0696" modified="2015-12-09" version="1">MLYGRLHSVLKNHKSVLRFQRCGSLSSRNKPGTLEFNRVMVANRGEIATRIFRALTEMEKTSIAIYAQQDKNSVHRLKADESYIVGQGLPPVAAYLNIDNIIEVALKNNVEAIHPGYGFLSERPDFAQKCKEANIVFIGPSSDILLKMSDKTAARQTAIEANIPVIPGSNGPVLTVEEVKEFGAKYGFPIIVKAAFGGGGRGMRKINNEKEIDEAFRRAYSEAKAAFGDGSLFVEKFVERPRHIEVQILGDKYGNIVHLFERDCSVQRRHQKVIEIAPAPHLDEQARKNMLEDALKLARHVGYENAGTVEFLLDNKGNHYFMEVNPRLQVEHTVTEEITGVDIVQAQIRLAEGKSLDDIKLHQDSIAVNGSAIQCRLTTEDPAQNFQPDSGRIEVYRSGTGMGIRIDSASAFQGSVITPDYDSLLVKIIAHARNHPNAVAKMSRALKEFRIRGVKTNIPFLINVLSQPDFVEGSVDTHFIDENPHLLKFNPSQNRAQKLLKYLAEVQVNGPLTPLVTGDPPKNVTPPVPETSNKPLPKGLRDVLIKEGPEKFARHIRRNKGCLVTDTTMRDAHQSLLATRVRTYDMLQVAPFVATNMTKLFSLENWAGATFDVSMRFLHECPWERLERLREAIPNIPFQCLLRGANGVGYSNYPTNVINKFSELAVKSGMDIFRVFDSLNYLPNLKIGMESIGNAGGVIEAAMSYTGNVADDSRVKYNLEYYLKLADELIKAGTHILCIKDMAGLLKPEAARILVSALRDKYPETPIHVHTHDTSGAGVASMLECARAGADIIDTAIDSMSGMTSQPSMGAFVASLEGTKLDTGIKMDTISKYNAYWESARQLYAPFECTKTMKSGNSDVYNHGIPGGQYTNLQFQSFSLGLGDKFEEVKKKYAEANEVLGDIIKVTPSSKMVGDLAQFMTQNNLTKETVIEEADELSFPMSVVEFFQGKLGEPPYGFPEPLRTKVLRGREKYTGPPSNYSKPVDLEQLKTDLEHKHGRKLRDVDVLSSCMFPKEFDDFERFRQAYGPVDKLPTKVFLVGLDVAEEVNVDLEKGKTLSVKYLANGHLNDVGEREVFFEMNGQARTVFVKDQEASKDIITRAKAVPGMKGSVGSPMPGEILEIKVKEGDVVAAKSPLFVLSAMKMEMVIDAPIGGTVKRVHLVKGDKVNGGDLVVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9G9</accession>
    <name>A0A0N5B9G9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9G9"/>
    <dbReference type="STRING" id="174720.A0A0N5B9G9"/>
    <dbReference type="WBParaSite" id="SPAL_0000268500.1">
        <property type="protein sequence ID" value="SPAL_0000268500.1"/>
        <property type="gene ID" value="SPAL_0000268500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000075">
        <property type="entry name" value="Transgelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF9">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000268500.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15810" checksum="4ECB2EA9A2C948C6" modified="2015-12-09" version="1">MASRTTAGGIGFAVQAKQDSKYVDKEGEMLLKWIKELSGENINTSGDKDNFFNLLKDGTLLCKAANAIEAGAVKKIQKPISNFACLENINSFVEFAKSKGVPVEYTFQSVDLFERRSLYSVTVTLINLGRILEKAGKTNPFVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA66</accession>
    <name>A0A0N5BA66_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps16_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA66"/>
    <dbReference type="STRING" id="174720.A0A0N5BA66"/>
    <dbReference type="WBParaSite" id="SPAL_0000293500.1">
        <property type="protein sequence ID" value="SPAL_0000293500.1"/>
        <property type="gene ID" value="SPAL_0000293500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000293500.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36476" checksum="61FEF7C461D84E8E" modified="2015-12-09" version="1">MINISEESASSLTSTHESPTSISIEPSSVTSSASCSDSTTSSVPTTNKQCTSYRLFPPMENPVDLAIGFECIAIADYDNGVLFIDTEGRVLMHLETKPYRICGVGFRDNNDYIVLLAYSEGKWSVLVYNTGDSSQIGTYECPSKPLIPSWALHRMVVLNDVVYLLATTDHLSAIWSLNLKTETWKTLLVQKEQDCGEYQGFDVRIKNDKERQILLTQQTKAQLIILTISNKDELLETGRIKMKRKNSQKWIIQGPRFAVWDSEQDIVVFDAAGKMFWFNGDTYKICKIISDIGRSEVCAVLAKDDWCYALCRNQLSIHAFLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC07</accession>
    <name>A0A0N5BC07_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC07"/>
    <dbReference type="STRING" id="174720.A0A0N5BC07"/>
    <dbReference type="WBParaSite" id="SPAL_0000355700.1">
        <property type="protein sequence ID" value="SPAL_0000355700.1"/>
        <property type="gene ID" value="SPAL_0000355700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF55">
        <property type="entry name" value="FI23523P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000355700.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49576" checksum="327A3B3A85005A51" modified="2015-12-09" version="1">MGNCVSADNRKFLEQLSRNENNSLSGRYSEFKVFVKQNKKFIPGTLRIGPNEILFIRNKDNIQVWPLNYLRRYGYTCANIFFFECGRRCSSGEGLFTFQSPQSEVIFQLIQQRIQQNYESQRNSRASSIVGNLQKSSTYGVPSTQSLRGIQPVQRFCSEGTTKNDYLYPHPNYGKNYCYDTYNDEYLLNRLSYSNFLKDRPRSIATSASHNLRASPFQPKPYICTNNKLSSSMKNFNSISLFENQILQDDIINEHIISLPNPLSNTPYERNNFYEGNFLPDKKKYHSYVNVSMLENNDYLFSNIDNIYNGNGKYCEKLDKGTFCHPPTVSPYMYQSSVSSNCYSVNSNNSTNTLRHNLDKIKEVVMPLPCNKIHYNKINDDKILKRDSISQKSRPSQGNNFLNYALIDFETTKNEDKKNSNNRINSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC85</accession>
    <name>A0A0N5BC85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC85"/>
    <dbReference type="WBParaSite" id="SPAL_0000363200.1">
        <property type="protein sequence ID" value="SPAL_0000363200.1"/>
        <property type="gene ID" value="SPAL_0000363200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000363200.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7940" checksum="8880FBC72BADFAC7" modified="2015-12-09" version="1">MEEKCLKVQDYTSEISDDALLLIFSELNWMDINNLKLVSKRFYGVVHRNYHRLERRKTAVSCQDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCM3</accession>
    <name>A0A0N5BCM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCM3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000376800.1">
        <property type="protein sequence ID" value="SPAL_0000376800.1"/>
        <property type="gene ID" value="SPAL_0000376800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07459">
        <property type="entry name" value="CRD_TK_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041775">
        <property type="entry name" value="Ror-like_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 22" id="KW-0420">Kringle</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="26">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="27">
        <location>
            <begin position="402"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="644"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="930"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="941"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="784"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000376800.1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116590" checksum="2C95E759F8C295F5" modified="2015-12-09" version="1">MADNVNSPPSVGHHHTRKLHRRHDDLILEPSGDYDLVYGDDSVIMTDNENGVTEQRPYIRLNSFLSNVTRETGNEVRFKCEAAGAPLPLNFQWLKNHVPLEKQKRVKIRTREYTSKLTITDLDVLDSGFYQCVVSNLAGSVNSTAVLRVNKASNTNTKKFKGKSDFTISGEEISNDYFDEMDSGRLIEDEDRIVDGSTFTMNGGDTYNPNFSNNNGIGIIDQWLNNVQLKVGECIPYKGSACKEYLEGRYILVTSDNREDIYDIDRNLRAANRFIQNMRGVKPECKEYSHAVACYHMFKVCDTSQTNKGYRRGYTPNTQYPPPLISLCYSDCQKLTNDLCPEEVQLASAHELVGDGAKAMIPKCNTLPLASDHCFSLLDKPIVNKNFDTSQEMTEKKKTELWCYMKDGRDYKGTINTSKSGRTCRSWIQSSSPEFNVIAYPELKISKNYCRNPGGKRNAPWCYVGNGEEELCSVSQCPKSIGFDDDGDGSSMATKFTKMWEDIPPQQQLMALLSTGFVTIILLVIIICCVCCCRKGKKNNVRRNAGTIDGKKHLLGTAHDETQTTTTYNRMTNQIKASSGIGMDNGISSPYEISSLLSRGTNPYNSNNQGHILQHGIQFSQHSQPSTEPPVEPYHIPEIQPQSIKIGSMIGEGQFSAVYIADHYSSNHVDGDLHQTVVVSLKSGCTMMEKQSFEENIKAIASFDHQNILKLIGVSYLDFKQITGVFDYQVHGDLHEFLKVRAPANHTYDTSDNEDFLKIGIQIAQGMDYLASNGYVHQDLATRNIYVSDQRTIKICAFQMIRKGYEKDYYKTPHRHWMPIRWMSKETIQHGRYTTASDVWAFGVTLWELFTYGKTPYGDYSNEDVIELINLRNLLECPSNCPSSMYSLMIECWNEHPERRPSFNEIYTRLQSWCISGAMQQPFLQFQTRASSSISGGSGGQKTAKTNSSNQSNSLRNGAPITNTINGVLYHHNSNGSSGTSQHSNPTKLNGFMHSTPISQTRNVKKHSDFDSSPLMRRPNGNFEYSEDDADEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCT9</accession>
    <name>A0A0N5BCT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000383400.1">
        <property type="protein sequence ID" value="SPAL_0000383400.1"/>
        <property type="gene ID" value="SPAL_0000383400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894174" evidence="6">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000383400.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40809" checksum="A9BF12FCA3B3F59C" modified="2015-12-09" version="1">MPSDNVFYLTLLMILCGTFSIVGNVNQLISNYCKLNLAPSNDNILKKNTRICINLLHIIYLILTFAIPCLVLERIQESWILGNNACIFNRILIMLERSTKLWLILFITIFQYKDYLQLKQITEVGSTKQDFFTKFSLKISVYIMIFISGSLILVMVPNCGAFKMILQTFYIDAIKIDIKQIKCGISVSDFYFTIVYGYSFAIEFFIPGCICIAIIIRWLFIIKIDSNENEDVLRYTSIIKSIVFLLSLSFYIFLPHWCVLLLKLQGYDIFGSYITEYLIYILDELSNINISLSPALSWFPLMLLSNNLCNYENNETIHQNSIKSRNCSRIHSRSSLLNLNTQKKYRIRTNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDX0</accession>
    <name>A0A0N5BDX0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Torsin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDX0"/>
    <dbReference type="STRING" id="174720.A0A0N5BDX0"/>
    <dbReference type="WBParaSite" id="SPAL_0000419800.1">
        <property type="protein sequence ID" value="SPAL_0000419800.1"/>
        <property type="gene ID" value="SPAL_0000419800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="2">
        <location>
            <begin position="273"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000419800.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39782" checksum="05FBF89D957927F1" modified="2015-12-09" version="1">MRFGLSLILFSYFSTMIYGELISIMVGTSIAVGLGSFLFYNQCKVLECCEAPWIKIRYKELSEALRKRLYGQHIAIAAVENLVSGHLKQVKEGKSKKSLVMSFHGWPGIGKTYTSTIIAEHLFEKGFSSKYVKRYYGSKDFPLPNRVNEYRENIQRWIAGNLSDCTKTLFIFDEVDKMSPKILDAISPFGQENVRISGKPANDAIFIFISNAGGDAIANKVREFYLKKGFREDLKLEDFENIIKEVAVNKGGLEESDMIFRGIVDVFVPFLPLEKKHIEECIETIFNEREYTNVEYNKKIKDFLLKQITFSPKNDPLFSVNGCRLIEHKMNLVSEKYYKKPEIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEC4</accession>
    <name>A0A0N5BEC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA_ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEC4"/>
    <dbReference type="STRING" id="174720.A0A0N5BEC4"/>
    <dbReference type="WBParaSite" id="SPAL_0000434700.1">
        <property type="protein sequence ID" value="SPAL_0000434700.1"/>
        <property type="gene ID" value="SPAL_0000434700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000434700.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41299" checksum="94BAF930C0F78252" modified="2015-12-09" version="1">MCTNEIISRALNPRIFSSTKELSKVLLENAIFHRKGEFLVINKPYGVPCLGYKQENGGVFNSSKKSDMVDEDADKIVVEKKPTSDVTIEKTLPFINKSLNENDIHFCAGLKRYISGPVVLPSSKEHFQKIKSSLHLASNLSGTNGFMPHRALVLCLGRPLNGSGEIYGNVSFKTVHGHSEYWFEEGKAKKKDLNRNFAIQGLLNYETIAWNGEISLVDISVVKFARHFPRIVLAHVGAPILGDTIYWRRFANIRGEMVAIELKSKMKANENYYYPRKLLKTLNMSEKDYASQIPIYFHVYKSVYPRYTNVRKSSANDLVVMAPPPEHFEAMIRILGFKNEVKKVIERQDTDYDDISDNIISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BED8</accession>
    <name>A0A0N5BED8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BED8"/>
    <dbReference type="STRING" id="174720.A0A0N5BED8"/>
    <dbReference type="ESTHER" id="strea-a0a0n5bed8">
        <property type="family name" value="Cholinesterase-like"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000436100.1">
        <property type="protein sequence ID" value="SPAL_0000436100.1"/>
        <property type="gene ID" value="SPAL_0000436100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF15">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894454" evidence="5">
        <location>
            <begin position="17"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000436100.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="64034" checksum="EC6083820C5B6853" modified="2015-12-09" version="1">MFKIFLLFHYFLAVLGFTPLEYTTRDGKIIGKSNSKFTSVTEFLGIPFAKPPTGNLRFKPPQQLKKVVPSDPFYADKPANTCLYAYEKSFYYGFKGYDFWHPKSLTQSEDCLQLNMWVPENHDGSVLVFVFGNGYDSGSPSLRVFNGAALAYSAGVIVVNLNYRLGVLGFGYLNGHKDMPGNMGLLDQQMGLKWVYDNIESFGGNKKKITLFGSGTGASSVTAHLFAPGSEKYFIRLIANSGTMLNTWSFQKTSMASLNLLALAKKFKCTGSDIQIIRCLREAKSIVNPDQSPLVQPFIPVESEDNFFMRNIRKKLFKREMKKDCDVMLGVTKDEASYLMPQFLKGTYYGCNFKKDKELESKGNMCLMNETHFNNVVKLIGFYHKYPKEDLDLLYKTYADKTVKEPRDWTKKLLSDFIFKCDIATFGMNYLSRVEGSKYFYQLNRMPRVSHWPKWMGVVHGYELLYEFGYIRTHWRYYSRSVRAKEKSLAIKMMKLIVQFVKIGKLPIKWKQFDKNDVPVAFIDDKYSSERGPSSVKSALTEGCKVIRKIQIKHPNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BER6</accession>
    <name>A0A0N5BER6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BER6"/>
    <dbReference type="WBParaSite" id="SPAL_0000448900.1">
        <property type="protein sequence ID" value="SPAL_0000448900.1"/>
        <property type="gene ID" value="SPAL_0000448900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000448900.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15863" checksum="AA3DD2E9F2790000" modified="2015-12-09" version="1">MATTRRIQTDYVREALDICIDLADGWESDGDPRMFTMEKHIMMIRELQDILQDAFETKIVRLIYSLRKARNNAIERIKYDFFRVYKTTEEQLRGILGVPFEEFIRSPRHYKYFVTEGETVYFEDVIQGPTHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFR4</accession>
    <name>A0A0N5BFR4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BFR4"/>
    <dbReference type="STRING" id="174720.A0A0N5BFR4"/>
    <dbReference type="WBParaSite" id="SPAL_0000482900.1">
        <property type="protein sequence ID" value="SPAL_0000482900.1"/>
        <property type="gene ID" value="SPAL_0000482900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000482900.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35511" checksum="A7EDC2A06A1FE889" modified="2015-12-09" version="1">MSVESSPINLYIAVGCISALFMLIIFGIFKFVNDRKKEKNDVNEVDRLIRNVQRQNARNAPGLRRRMNVRRDSDDDYSDDNMEDDDDDYLNDDAEIDFSKMGKKKAAKIQAKLERKRQREYEAREREERKRQQLLKEQKEDEIRAKEEAAEKEREEKERKEREEREKREYEEYLKMKEAFNIEEEGVNELDEDASRNLKEEFINYIKEVKVVNIDELASKFNLTVSDVSNRLSTFIEDGSISGVIDDRGKFIYITDEEWRSVAQFINSRGRVSLQEIVDSSNRLISLKPNLPSNNEISVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BG85</accession>
    <name>A0A0N5BG85_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc transporter SLC39A7</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BG85"/>
    <dbReference type="STRING" id="174720.A0A0N5BG85"/>
    <dbReference type="WBParaSite" id="SPAL_0000499300.1">
        <property type="protein sequence ID" value="SPAL_0000499300.1"/>
        <property type="gene ID" value="SPAL_0000499300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF25">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894462" evidence="9">
        <location>
            <begin position="26"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000499300.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="51867" checksum="6016C72A1794076C" modified="2015-12-09" version="1">MKFLLKNKLLLIGAILAVVVFIVSSQHHGHTHDHHGHAHDDHGHSHEHPAAKYGRAINEAAQEEAKKAHSHGHGHSHGGKECHGHSHDDHSTHGHSHEDHSTHGHAHDDHSTHGHSHDDDSTHGHSHDDSTHGHSHDDSTHGHSHKASKRSTTAKYQEYAKDSYLSFLNDPVKRLWTYSIGATLLISAFPCFLLLTIPLQANTVENGPLLKVLLAFGSGGLLGDAFLHLIPHAQPSGGHDHGHSHSDSGHGHSHDNTVGGWVLGGIIAFLIVEKFVRLMRGEDGHGHSHGVEKKKDKLSDEEDDKKGGANSKKKKNGKKVEEKKCTNIKVTAFLNLVADFTHNFTDGLAIGASFIAGPYVGLITTITVLVHEIPHEIGDFAILIQSGFSKKRAMLVQLITALGALSGCIISLLSTDATSLAEEAASSWVLPFTAGGFIYIATVSVIPELLEGNSNVWQSIKEVIAILIGIGMMYLIALYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGJ9</accession>
    <name>A0A0N5BGJ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGJ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BGJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000510200.1">
        <property type="protein sequence ID" value="SPAL_0000510200.1"/>
        <property type="gene ID" value="SPAL_0000510200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000510200.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37781" checksum="007D75CA6D659C82" modified="2015-12-09" version="1">MKFHAIDVDKKFKQNDDMSAKIKKQKGCESIWRQILLSIRFFFIYVFLFLTKDVPRFFCLKRKNVEGQTILITGGAMGIGRRLAEKMAINEKCKVIILDVNEKEGLRAKEEITASGGNVYFYKCNVTSSDDLNEVKKEILSNPKLGRIDILVCNAAILKMGELKDLTENDYRISNDVNILGYILTTKTFIKEMMEINRGQIVFIGSICSFFGDYCGSAYCTAKFAIRGFLESVRVELIDGGYDNIITTIIHPYFVKTSLVTNQIKDPYSTFFDVISVEECVDSAIDGILKERFEVFIPGRLSFFCYNLKCLQTVGVFKQALKFLNFKHDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH18</accession>
    <name>A0A0N5BH18_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mariner Mos1 transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH18"/>
    <dbReference type="STRING" id="174720.A0A0N5BH18"/>
    <dbReference type="WBParaSite" id="SPAL_0000526500.1">
        <property type="protein sequence ID" value="SPAL_0000526500.1"/>
        <property type="gene ID" value="SPAL_0000526500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000526500.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19805" checksum="9CDB23A33F3D37B9" modified="2015-12-09" version="1">MFDNRRRSSEWVNKNGSPKNFPKLKISNKKLLLTIWWNCDGIIHHKFLNPGETKTSDRHCKEIKEMNQKLSVLKPALVNRRGPILLHDNAKPHVSRITVHKINELEYETLSHSLYSLDLSPTDYHLSKELELHLRQKKFSKSDDLKIDDLEFLDSRDGSFYSNGINRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH68</accession>
    <name>A0A0N5BH68_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH68"/>
    <dbReference type="STRING" id="174720.A0A0N5BH68"/>
    <dbReference type="WBParaSite" id="SPAL_0000531200.1">
        <property type="protein sequence ID" value="SPAL_0000531200.1"/>
        <property type="gene ID" value="SPAL_0000531200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="115"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000531200.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49692" checksum="A72F7C099BD9BB1B" modified="2015-12-09" version="1">MTIPYRSRYHEQNLNPKWKPFEIHINQLCYGDKDREFLIECYDWDQDGNHDLVGQCKTTVNRMVLGKDKLLPLIHPKKVKKNKKYVDSGILHLHKVYCWMDYTFLDFITGGTQLDFHVVIDFTHSNLPMEDHSSLHRIDPDEPNQYEIAIAAIAETCQHYNRSKIFYAYGFGAKLPNDSKVHYNFPLNLETNNPRCYGIEGLLEAYMIAQSKVELSGPTNFAPTIRFAARQASMIPNDGSRYCVVLIITDGVISDMEKTKEEIIKASSLPLSIIIVGVGYDSFEEMKVLDSDKVMLNLHGKYAKRDIVQFVQLRNFLPPHRVLTEEERSIAKEALAREVLEEVPDQLTSYMKTKGIFPREAENPFIEEISPTSSSFNIDFDNTPTEISPTKTSAYSPKISRTISTYKGDNYNRQRRILPQTPDEEFDALVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHS7</accession>
    <name>A0A0N5BHS7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHS7"/>
    <dbReference type="STRING" id="174720.A0A0N5BHS7"/>
    <dbReference type="WBParaSite" id="SPAL_0000551200.1">
        <property type="protein sequence ID" value="SPAL_0000551200.1"/>
        <property type="gene ID" value="SPAL_0000551200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="66"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000551200.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51081" checksum="09E4F6BAFFEFD4A6" modified="2015-12-09" version="1">MDNERVIESIDNSSYLLKNVINNLTETLTYEDQLPMDEGYQNGIYKQFRFYIRYIIPVFCVIGILGNSMALIILKTNYWLKRLTSNAYLTMLSVCSCIFISCLFIVFTDTAINTWSFYSSWTYGCKLFTFLPQSSDFVCSWMICWVSFDRVLILYRPKLRKYICNKKFANYAILGTILIGAIFYSWCFYLADIEYDIDGRPFCGLRSDEYVLGISLQDIANFFLFFDLTICTILPSIFIVTVNCLSIYRYRECMKIYASGVLRVRFLKVPSTETNENNLQTGGGNGIDDLTHTKKTLFGMSSMGGGCSGQSTTNTNTKSKKKGNKLKTSDLTLTRSLLIVTSTFICLQLPNYALRIYQNIFNIPQEDQPFNFILFMSHIIYYAHHAVLFYMYIFWSPQMKKQLKPTALKLIECYCCKAVPEFGHGQSVPYMKRGDRNYFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIC4</accession>
    <name>A0A0N5BIC4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CC2D1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIC4"/>
    <dbReference type="STRING" id="174720.A0A0N5BIC4"/>
    <dbReference type="WBParaSite" id="SPAL_0000570800.1">
        <property type="protein sequence ID" value="SPAL_0000570800.1"/>
        <property type="gene ID" value="SPAL_0000570800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21528">
        <property type="entry name" value="CC2D1A-B_DM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="600"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000570800.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="87199" checksum="AE63B262C62E755F" modified="2015-12-09" version="1">MCLAEKIKVKRQSHMTPRKFLHQKTLKNSGTQTMKSMNFDISNFEANIYGDVHNDPDLEKELKSLGIDEDDDSDCEAELARLMKESGHDVDDDDLVLDKLPKDKYEKNGNKRKIKADEGVLESDDEGLLDELNQITGEGVKPKANVVNPPATIDKEMITKLDNALTFYTKQLDASKKNGDNAKVRRCQRSITKIQELQSHVKSGGKINEEDIPPVPKGVETNEIASKVRKLDDPPPLPPRNSVQSSTLLVETKESKLNKIQNLLKERLSQYLDCAQKAKEAGDKEKTLEYVQFVSQFKEALKAIDITNIDDCDPDDIPPPPEPYKAKKSEKPKSLADDLILRRQFFIDYVKQLQTKGEDRKVRSNQRIIKLYDEAIQIAKQGKLPEINDLPCPPGMQPISVNNYAPPPVQTKPPSQTKKSPDERKEQPPSSSTRKASTVSIGSTAKPKLDTSKLSKQEAQSYFLKRRQKRFKEQAIVSKQQNDIEKAKEYLKVVKGLEPMIEASDNGLPTDLSKVPIPPQLNIPNSALKCTIVSPEPFFSKIEKTLMKQLAYCLQNLPQIVAQNDPVNALLYEDLTLDTLEDIVYLRKSARGNRLPKFQYVEKKLPRAQINTDLDDGTLEFTINSALNIKPLTGYKENDLCCYIKYEFPYPHNSHQVGTTAVVNYTNSPEYNEKIIFKIGRGARAFQRVILRGKLKLEIYHKGGFLRSDKLVGNVEVPLSDLEHFATVALKVPILEGRRKTDGTIEVAFRQSKAVGTPKMDNVIEKWLILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJ70</accession>
    <name>A0A0N5BJ70_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exported protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJ70"/>
    <dbReference type="WBParaSite" id="SPAL_0000599500.1">
        <property type="protein sequence ID" value="SPAL_0000599500.1"/>
        <property type="gene ID" value="SPAL_0000599500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894339" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000599500.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15036" checksum="D28207C4E2328C7D" modified="2015-12-09" version="1">MKLFLFLIISVIVITQSYGISVTCGPSDDDCYIDTGNNFTLDNDFSKLLSQDQINGINSILNNSTLSNRNKRVELNYFINKIVPSNTIKEYGKVLSQKISEEVEETLRNSGIYEPCFPFCNITDLIFTNFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJF7</accession>
    <name>A0A0N5BJF7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Katanin_con80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJF7"/>
    <dbReference type="STRING" id="174720.A0A0N5BJF7"/>
    <dbReference type="WBParaSite" id="SPAL_0000608300.1">
        <property type="protein sequence ID" value="SPAL_0000608300.1"/>
        <property type="gene ID" value="SPAL_0000608300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="5">
        <location>
            <begin position="267"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000608300.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46867" checksum="129CC5E9731A8F62" modified="2015-12-09" version="1">MQQTLDFIINPLDTSEVMILNWDEKKNVIVKNCSILNLFTPNSNELIIPVNGEEESTNNLLSPDEESLNSIPSLPSPPISERDIMKESLSMNDLDTPHINKAQTLRRISPSPIQTRRTTSIASHRKPSPDVIIKTKSPITNVKPRTPSVPKSSLNISGSTNKINTIITKDSRSKSISSLKRDSLSQASSNTSIPNKISPKVSITTSIKKTINRSSSNNINKINDSPSKPKVTARPPIVPTEGPSTTLMSKFQTIQTKCEAENKGMLRELETIVSLIKNGGLKKLLSQRMTFSKTNSMGIVFRELLNMESIWSLQTCELAIPHLTNLLSSQNKDNIDIGLETLKLIVTEYVPIILENLNIPEEYNFRGDVVGAERKERSITCHQRLLQLFLNGSFLKERMSKEQQCYFQEIIDKCGLDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJH5</accession>
    <name>A0A0N5BJH5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJH5"/>
    <dbReference type="STRING" id="174720.A0A0N5BJH5"/>
    <dbReference type="WBParaSite" id="SPAL_0000610100.1">
        <property type="protein sequence ID" value="SPAL_0000610100.1"/>
        <property type="gene ID" value="SPAL_0000610100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000610100.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14886" checksum="BBC02B68DB1DC125" modified="2015-12-09" version="1">MSKRGRGGASGAKFRITLGLPVGAVINCADNSGAKNLFVIAVYGIRGRLNRLPSAGVGDMFVASVKKGKPELRKKVLQAVVIRQRKQYRRKDGTVLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJT5</accession>
    <name>A0A0N5BJT5_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="STRING" id="174720.A0A0N5BJT5"/>
    <dbReference type="WBParaSite" id="SPAL_0000620400.1">
        <property type="protein sequence ID" value="SPAL_0000620400.1"/>
        <property type="gene ID" value="SPAL_0000620400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894372" description="limulus clotting factor C" evidence="10">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="46"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000620400.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32585" checksum="5159C2693952FD9E" modified="2015-12-09" version="1">XNIYKMVKFLYTLFLLFIIVSATSGSYHCGQTPIIPNVNKKTSVDIVGGSDAVPYSWPWQVILCTTGWSSLCQLICGGSIIAPGWVMISGECGNSVIDFESTFRIRAGVYDYYKMNETGETLHKIKKVHVHPNYQGYPNYERDIGLIELEDQITFNNHVQPICLPSTDKNVVVEPNSAWATGWGLTAEEGSDIPNKLKQVNVPFVNEKTCDSEYPNQIKPDIMICAGKKGLDTCAGDAGGPLVAQSKSGTWYQYGITSHGLGCAEYKHPGIYTRVTAFCDFIETTTNGTVTCIKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJY8</accession>
    <name>A0A0N5BJY8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJY8"/>
    <dbReference type="WBParaSite" id="SPAL_0000625500.1">
        <property type="protein sequence ID" value="SPAL_0000625500.1"/>
        <property type="gene ID" value="SPAL_0000625500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000625500.1"/>
        </source>
    </evidence>
    <sequence length="1229" mass="141921" checksum="32350CE029B14D39" modified="2015-12-09" version="1">MFSNIKVLKEVVDCIPQSVDFGFTTVDICYIITTSDYLIFISKNGIVFPFFTSNCQCQSLPYIKFPTKSGTVSAIRVEDKLNYIAIGFDSGVVYILKLDDNCKPLKIDGIHDGRSIVDMIWSEDGNYLYIGDNWGHITLILINWISRIIQYKYLCIDGMPIVKMIVNKKESKLFYITNFSFVSLDLSDIYNIQRKVFNFEDDREELEYRGLLFLHFTSAEQLNEINVIDNEGFVYVFDLNNGKLKKQYSLDGCENIENCCLIPDKGIIFKEYRSLKYFVFEEVNDELILSPNNVWNIEDFNQVSFPLLNEDDEDLYNIVDICYHKQNEILFCLINPGICIAFSENSKNSLFLEELCIQESTKSEFLLTTEILNFTASTTKELIDKKMPSVLAKLDKIKNVASEKVVEKLEEARDGKFNDYIELPNTSLEIVYPFNVFKEISDDKEDSIELCVSKKPIKVKKNKKPYDKKLSSIEYLNEKISECNDNFPNLIEVSNTIINNTRPIRKKSPELSQESFIEIKTNYEYELEYQQYLLNNLPLKDDINKKITLDEECSSISIRSGESFKVKPFSISMVNEEIKDDKLINTSKCDIKNYINLSCHSISWNYFSLPYQIHSFTITSNFLITTSTNEWRCDYIELNNDKKWKKCINYPNDIIISNHSGTLLWKITKGKAFSPQCDNISNLSYIFSDYCDWKCQTPNDYVYDASFVDDDVWYLTKQGPFVKMNLPTMNILYHTPIKYNKNIVFDKISASSNGVWILSTGKCIIYARVGLHKCQMGVEWIKVKSIKRIPYNIVSIALHATFAFALDSSGCLWMLPDVTKKNALGSKKGWYKMYFDFILPKNTILMSDIDVSSKGMFIKNGCKLFYTSSGFINAHQFYSYDNHLTFYNFQKISNLSSNEVVLLHTNGDFYIFNTIDKKYKVINTDSVENCSDNKNINKIMMSNTNSVFFLNSSGSLWIHQKPSSLNYMTLNEWELISFNESIGDNVIITDFTLTNDILFIVINNRYLYKYHLATRQISHYPDLPEEVGDCSVFVSKTTSIIIIGDKKKFIYFSYSLKNNNWIKINNNSYDELISKIVVGDNVIWGLSQKLGSLYYLENFDETVNPKGDRWRKAIDIKIIDIALNLDDGNELLILDKKGILKKHDIISLHLPFNDSLNFTIPSSEKSIIYQEYISSFNVNSSPLKNNIQSQDINVDNDALNSISINSFLQIVPKIARKTISGVTSKIFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKX1</accession>
    <name>A0A0N5BKX1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKX1"/>
    <dbReference type="WBParaSite" id="SPAL_0000657400.1">
        <property type="protein sequence ID" value="SPAL_0000657400.1"/>
        <property type="gene ID" value="SPAL_0000657400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000657400.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32889" checksum="DDE50416F73DBBC0" modified="2015-12-09" version="1">MVNVILVVDIIQLIYKLPSMLLMILSIFVIIKEIKNKNVNFNTQFYIIIVCKLTSEIIYIITIFIFMKLPKWGFYKNFLETNDWTATIFYFLAAQQTTFMFLITLLTSINRYIAVKYPLSYNFYFSKLRSTIILLSFITLSTIIGLGNISFEARFDKIDSFDYIIPSFVSENAFYYRIFYQIFLFGILSIATCTFNVVAILTLKKYNQIGKKFKKELYYMIYSIFIFITILFVEAFFVCRLTALKYETKFFIQITFILHVVAFDLTSVGDFYFLIYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BLL0</accession>
    <name>A0A0N5BLL0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine-rich antigen</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BLL0"/>
    <dbReference type="STRING" id="174720.A0A0N5BLL0"/>
    <dbReference type="WBParaSite" id="SPAL_0000680600.1">
        <property type="protein sequence ID" value="SPAL_0000680600.1"/>
        <property type="gene ID" value="SPAL_0000680600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000680600.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="60287" checksum="69A01599F48C6338" modified="2015-12-09" version="1">MSTSSDISDDFEECEEEFEDTTISSSILEDESYEEYEEIGDDENVSSSESDTKITINLVTSHNEINLEKTISLHVESDDEHTDEESNYDSDDESSDELSDELNSNKNEYKSSPNNSDNNKENKGESTQVFLNYSKIYTGSNECINNSQNNKNFISRNDKIIEMLDTTVNKVNDDINKKFEENHNNDKENQKEDPEEEEYEEEGGCGNEEDDEEYEEDEEYEEEEEEEEEEEEEEEEEEINDCIPNSISTAIFNYIRWSKISKIDEYDHIYQNKSSEESEEGSEEDEEEQEEIASENEKDNEEESSFKSNNKLIKDLNTQNDMNIIEKNNNISKDNFIIDSKHNDDIEFDSKTINIKPVNDKNIINDLKIYPEKYSAVDDKNFEQNLFKEIVNDQIETNECKNTADISYTISLSSSNERVNKIENENLCDKNNEFDNLRSSLEIENEILYEMLFRWLMKKIKKLKQTEGEVDIEYFKKLFGENMKDVQNDYPDAYDKLYTLCMNKVRNAIANEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN35</accession>
    <name>A0A0N5BN35_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN35"/>
    <dbReference type="WBParaSite" id="SPAL_0000731500.1">
        <property type="protein sequence ID" value="SPAL_0000731500.1"/>
        <property type="gene ID" value="SPAL_0000731500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000731500.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13434" checksum="F7B369DB0ADCEA11" modified="2015-12-09" version="1">MTTSGNTLTTTTTSLPLVTTTSLTTTVTITQTTTTTALTTTTTNDITQTETQQPDGTSVLELECVSPDPLTTVTLFWNDGRNGMTASTTNTITASLNCGNNGNWELTQPDPATGNDKLVRYDSYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNH0</accession>
    <name>A0A0N5BNH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNH0"/>
    <dbReference type="STRING" id="174720.A0A0N5BNH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000744900.1">
        <property type="protein sequence ID" value="SPAL_0000744900.1"/>
        <property type="gene ID" value="SPAL_0000744900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="280"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="638"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="9">
        <location>
            <begin position="829"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000744900.1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="118365" checksum="10DE4E3CB9171E1B" modified="2015-12-09" version="1">MFDPYHKVWRLIWKNYFLEKISKEIGYITECLKRRNLLDSYNDFARLQSKNFSSFEEAFYTWAERYFPEYFIEAIDLLKKEIPNSDYFLSGVSNEMMGNVNLLFKKVKEIDGEPLIIELLMSNLHIGDVLDYYTNLNQEEYSYVVDVVKKLYEKFSNVRRLSNGGFIKCLIFCERFINRNPNLIWEDFLKMLFLLEGKLGRIVDILDPVKASIIRREKEDRDAKIRELIYTVDVNINCPIELKSFRQQYDYVEHFNKNGHPKFNDIRNSYTLRDYQVELVTYAIRGENVIIMAPTGSGKTLCAVEIMRLHMLENSSEGKGYRCLFIAPTGPLVLQQCQVLKNYLCDLYTVTTLSKNASEDEDVLKKILAHDVIVCTPQLFINQLMSNKESQKLYFSDFTLIVFDECHHCNSSHPYKQIMNLFYRAEGDYEKPQIVGLTASIGTGKTVTHEGCYNYYLEMAVNLAAKRICGVYKNRETLNKVMKLPVDEIIEFDVYQNDLIKYLDETTQLIVNELLRIDGASNLHEHLKSHPIGGVEKAGFFSQVLKLSTFKAFVKNPEVLQWIDNAVKAFTHIYLVREASQILPILYVNLYCVDYLENVNSVMRHSISRDILVGYLTDMKNKINNEIARNRSSFKTPPIYERLLKICNDQIKKLPNSRIIIFVPTRFVATTLCDSIVRICKAKGSDMRPGYIIANGNTKMTRQSPQDQKFTLDSFRSGDINIIIATTIAEEGLDIEECNLVVKYNVGGNEKSLIQRRGRARAQNAKSILLTCNNTYTSAEITNIQRERIMAEIAEKINSMSISKFTKEIEFKKMEMKRIADAKYENETERRRELYGKVYKVCCRNCKEMITLSNTIRRFNTHHVVLDLKIFDKISIDTGRMANPGPTFSVVADGVCKNCCHENEDGSIEKVKLGEIIYIDDHFYFKIILRNISFINNIDGDAYEERNRWDAVGNTLFLVPNASFDEVDYYNLNFEKGTNKYYVELMECKEDLRIQNNNITIWKKMEEKELKELEKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP51</accession>
    <name>A0A0N5BP51_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP51"/>
    <dbReference type="WBParaSite" id="SPAL_0000767900.1">
        <property type="protein sequence ID" value="SPAL_0000767900.1"/>
        <property type="gene ID" value="SPAL_0000767900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000767900.1"/>
        </source>
    </evidence>
    <sequence length="50" mass="5888" checksum="87A279250AC3FF95" modified="2015-12-09" version="1">ILKEILSRVGFERVHVNPPKIFVKKRNLENCVIFGKKCNLGFYIIVIHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP95</accession>
    <name>A0A0N5BP95_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP95"/>
    <dbReference type="STRING" id="174720.A0A0N5BP95"/>
    <dbReference type="WBParaSite" id="SPAL_0000772200.1">
        <property type="protein sequence ID" value="SPAL_0000772200.1"/>
        <property type="gene ID" value="SPAL_0000772200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000772200.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="16398" checksum="19000FD7456E4A67" modified="2015-12-09" version="1">MASTANAQLIAAEEAMYAPFFGSLGVTAAMIFTAAGSAYGTAKSGTGIASMSVARPDLVMKAIIPVVMAGIVAIYGLVVAVIISGKLAPGGKEYTVNSGFSQFAGGLVCGLCGLGAGYAIGIAGDAGVRGLSQQPRLFVGMILILIFAEVLGLYGMIVALILGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPG4</accession>
    <name>A0A0N5BPG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SMP-LTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPG4"/>
    <dbReference type="STRING" id="174720.A0A0N5BPG4"/>
    <dbReference type="WBParaSite" id="SPAL_0000778900.1">
        <property type="protein sequence ID" value="SPAL_0000778900.1"/>
        <property type="gene ID" value="SPAL_0000778900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF16">
        <property type="entry name" value="KELCH MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="105"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000778900.1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68588" checksum="337807377120C1FC" modified="2015-12-09" version="1">MVERDNISMEEKEYSRVVEKDITSLIVIKINNYPWIIWPMMFLSLVGFFRIFSPKWVSFNELTLVFLVAVMTLLIFTWLESVLRNQESNKIDIRLLQSLITENKKLKQICLGNEILKGFWPYVTEFAASIIKDKLEPKIQKQLPNILGKFSFDFIDLGTKSLQIFPTRCEVDAKNTDKMIIEMNVIYDGDGAIEVLIGKVLGGIEDISFRGKIQVILEPILLTPPFIGDIKLTFIEMPILNLKMTGLGKLPGVGDTIIGIINDLIKSNVVFPKKITVPIANEKSIRRSLIIKNIRNGIAEDMEITKPTALTTVGRVFLLGGETIDKKLSHNIYFDVNSSHYYNGPGMIRQRKKFNSIFYKDKIFALGGIYENKDHSYITGSVEVLELSKRRWKLLKTELHIPRHSFCCELINDSLYAIGGDNTEKYLDTVEIFDFEKQKWYYSVSMIASNTAFASCTLNNILYTIGGVNNSSLSFFDHREGKWVTGANMNDSRIYCTAHCSNNNIYVIGGYDEFHEPYKSKVEIYDIRGKKWRYGSSISTARACHSSIMIDNIIQVYGGQTHKDEILNSVEYYNIKKNTWIDGPKMTIPKTFFSIPKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPM9</accession>
    <name>A0A0N5BPM9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ELYS-bb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BPM9"/>
    <dbReference type="WBParaSite" id="SPAL_0000785400.1">
        <property type="protein sequence ID" value="SPAL_0000785400.1"/>
        <property type="gene ID" value="SPAL_0000785400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="2">
        <location>
            <begin position="351"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000785400.1"/>
        </source>
    </evidence>
    <sequence length="1490" mass="169796" checksum="259A04CAC1D19A65" modified="2015-12-09" version="1">MSLDFHRPSFLQQRLVEVESERCNLSTAFGLSEYKSGSPRIGKYLYDSEGKCKYFVVAVEEYLLLYNTEQVCGEPRKRVEYCLGKGARIHDCAFMYLEDNSEGLVVGATTVNEAGVKCYGLYLLSAGREAIILDAMAFVKDCKKVFVVYDELHRDELKKIDPAFHNHPHLIMVGMEDGAGYLTHFKNTSKSNALRDRPPTRPTSAFNVLRGFRDKTNTFFTFDASGETTRLKLSEVEVTSISYVHSCRCLLIGFNFGGVVSINLLTQQKIKIRISRGEIRAMQVQEPDDDPRPTSYVWVGSLIGGRLTFTLISLMFYTDPSDPSIVDMNKVALSKRLEFEADKFSHFLALKGITRERTLKADNTTRLEDIHKKDTTLMLFSWINITSKGISLEGALFDLNMYYYKRMVSQIRDDGTYAKQCPLISRFSMNNPNGINFAALLDINLDPESLYRGKSDLIENVDQFFYPSTYGFELHTFTKNAATVLSCEPIQFQFFERLTPLKEHLNEPAMAIRCLTALGFISVKESSQITEHSAKCSAILSTLLHNFSGNLIIQMIKDSTVTEKYLVLLIDWLYTEIQKCVDDFQRIVSKLFEENSEELYSAQITKVNHYIGVFEMMKEIIVAMKAKDLSDSVRGQLYVKEVVIDTFLLYSRLMNVFVEVGLFPITPDVIELHKSLEDIHNKRVLLSRRKLYKLDIEKLLDLLSKTDLECVEKLYPPRNPAILIDLIVAPEIKIIGKLRLISYYALDIGFLRNNNTFIDKVQYNVAFFYKEKDPIDFFEIKKCWREDSIELEDYKENIFTIRPENLDYDYKNNLTPRVVERICQKVYMSDGELKDLHDYLLKQPHGLFIWNYIAVKREEFSMIEPININVLSNVPDEWKALCETSKNLYEKVKGNSILWRYKMPSLYNKKSGLKNETFCNLTHVSIHGKSQNDSELVADSSKIKSIDTIVDKDYLDHHFAAQRYENLLKTPMSASRWTRVSRLTNINKSPPMEQPKQIQPTSIMKSQERVSRLRPGMKIGSRIRFNLPDTSSIADNTAGDSTCSTDNNDSMNSTFNGVFHIEKSDEQTEFDDVKCVYKAIIQEKIEEQMSRTVLHEDGRVTVMETQTDEEMLMSDLENSPAKTGVDLINHMEERSKNYNIELPTVVLVQAAKEKLTLQEDNTPVLKRRKSSIIKKTLAFSGHKGASEINQDDKVNVLKRNSPFDENDEEDSGSAKKTRINEEDDSGNIKETRINDNEDEVAIETDISTSTLRRSARIHKHSVEPEPPSVPTTRSKNKRGTTSRETSVDPDIPVESKTGPKRGTTSRENSIEPDTPLKTRTKRVAASRETSAEPEASATTKTRSKRVAASRETSVDPEVPATTKTRPKRGAASREVSVEPDVNSTTKTRPKRGAASREVSVEPDVHSTTRTRTKRGTTSRETSVEPEVPATPKSRTRRGSSCEQETELRRSTRLRRTPSKEFESSTKKGSKSPSRLPTILETNAVNSERQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BPR1</accession>
    <name>A0A0N5BPR1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ING family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BPR1"/>
    <dbReference type="STRING" id="174720.A0A0N5BPR1"/>
    <dbReference type="WBParaSite" id="SPAL_0000788700.1">
        <property type="protein sequence ID" value="SPAL_0000788700.1"/>
        <property type="gene ID" value="SPAL_0000788700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000788700.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="50030" checksum="286183277C6A458D" modified="2015-12-09" version="1">MQYLEDFLEILESVPPEIRYITNQMRLNDVSLEESENLHKKIESFMEVKDIMTPEQREAAINEIRSIQHEHTNKANIRCDLVKKLRTIFDLYKNRFEEDLRNYKLELEAEAPGVTETIENRYNENQRLSRESGNLRRTNGYGIENLVMYYPDGEESLIYNSDCEVSRSSIGGQTPRHNSHGDIDIPPQLFDKLSQQGLRDRSSTFTTKLEDSETNPTKRRRTTATLPTMNISNTKCMTDFTEAWFRGPSGAITPNFCMSPNTINTNKVSLGSYQDSNQVPFDYKKNRNGRQSRLSNKSHEIIGDNGCIDESRRGSRYSSRHTPDTPSFTSALNTCNNNIINREHTPASVMSLSDDEENEIVDEEDEEEENDNRIWCKCREKSYGLMVKCDNDDCEYRWFHGDCVGITPNNKPSINEKWLCQYCQQRIRNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQH1</accession>
    <name>A0A0N5BQH1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQH1"/>
    <dbReference type="WBParaSite" id="SPAL_0000813600.1">
        <property type="protein sequence ID" value="SPAL_0000813600.1"/>
        <property type="gene ID" value="SPAL_0000813600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055805">
        <property type="entry name" value="DUF7381"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24100">
        <property type="entry name" value="DUF7381"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="489"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000813600.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="75462" checksum="1251C92739F50704" modified="2015-12-09" version="1">MAYDLAITYTVLLIRNREFFQYRGNLYSTKNDMTEDIILDHSDIKTDKLLLLNIGKFTKNTEAVDPYQYIYEDPFPIFAKKKISAVIVHEHYRDGIITYTCLNKAFASFKKAHSYASRMTVKFFFHPNKKYKIKLPDYMNLPKMVKRFSVSGRTWHSVWDNCYYYKCFAANDFMQLKSRFLNEINKYRYFHGVPNVTISKYSTTLAEKYLRIILNTEPRFIDRKLLHNFVSTPFYLAPLIMKRWYDENKKYNYETKATITGTEHFTSMIWRNVKKVGFAVEERDDIVHFVCVFYPLPNIHLLFKTNVLKRQIVHIAYDLAITYTVLLMGHREFYSYRGSFYTTKNAMMKDIILDHSDIKTDKLLLLNVGKYNRNNEPLDPSQYIYENPFPVFAKKKISAVIVHEYYRNGVITYVCLNKEFGNFKNAKSYALRMTVKFFFHPNKKHKINLPDYMNLPKMVKRFGFSNRIWHDIWDKCYYYKCFSVNDFMQLKLRFLDEINKYRYFHGVPRVTICKYSTILAEKYLRIILNTEPKFLDRSLLRYYVGLPFYLAPLAMKRWYDENKKYNYETRSAITGTEHFTSMIWKTVKKVGFAVEERDEILHLVTVFYPQPNIPLLFKTNVLKRQIAYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQU7</accession>
    <name>A0A0N5BQU7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BQU7"/>
    <dbReference type="WBParaSite" id="SPAL_0000825700.1">
        <property type="protein sequence ID" value="SPAL_0000825700.1"/>
        <property type="gene ID" value="SPAL_0000825700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="Integrase_cat-core"/>
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        <property type="entry name" value="Integrase_H2C2"/>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RT_RNaseH_2"/>
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        <property type="entry name" value="PROTEIN CBG26694"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="630"/>
            <end position="814"/>
        </location>
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    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1271"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
    <sequence length="1421" mass="162937" checksum="9EF26FAF961527A9" modified="2015-12-09" version="1">MGDITLRRSDRLAVESLLVTLRTLKESESWSEEELERLAIQKFRVLQRYNPGSRRLIEECRKILKSVSRRSENSEKKVDSKKRKKRSDFTGRMSVSGNENIVPVATTVPTTPTITVAGSRPLPFENTPTVTGVGGHHIPFVGTPVVTGIGGYQTPFGMQASVPNYIPYYINYPPNHQATSSLRILSNITKYSKTNPRPFKHYIEDLQVMFRIEKIPEEDWGDILWLSLDDQIREELGHIPESVKTSYISLKATLMEKFATHPEAKQSRMEADVFELNVADGEKLMKSLKSYVELMKKGFSDMDQKQLVEAAEKILYKIKVFGDLQELIFEAYAACKEYIVDARRNRRSADNEEKKAKNVIRCYYCGGDNHKKSQCKKLKNESENNKNLSNINSKSVKNTSGRIDKGRKNGVSVLAEVSGKEAEIYLDTGSDINIISVDDVEPLKVKNIKLKTERFEVGGGDESNVNTLITTGCGDLDVKFGACNFKVKCHFVTDNRLFAPSLMMLGNEFLDRLNSYKVDNQNKVFILNDLCEVPLILHKIENSFPCEGKKKVRRVNVIRDEQMVHEEEKLKETYKEAFSLNNFDIGRCVVPATKIQLVKDVELPKPVKYNYNPIKARQIAELKIPSMEAGIIVPDDDMSCKFVSNHVLVAKPRGLWRLCLDVRILNKYILPMPIDLPNIEQVIYKMSKQKYFFCIDLTQSFLQIELLKEDQDLFGVYTHKGIYKYTRVVFGSRCSSQLFVKALNTVLKDFIESNNDDWGVICYVDDIVGFAKSFSQLKTLAKDVILTLKDNGFKINREKSKFFARKCTFLSYEITKDGFTISDAYLDKLKQYEMPQNVKQLKRFLGMAQYFKRNLNNLGLIIKPLLNLLKKDTCWKFDQKCIDAYNKVIDLMTSKPLICSPMYDGREFYLMVDSSLDGFGSMLYQLDGKKKCVIAYHAERFKEFKVRPSAIELELLGIYKALVHYSSMLYGCKVVIQNDHKPMNAYTKTTLSPKSLYYIEKMEEFDYQIVYKDNNSVKVVDSLSRQFITGIITIDQHLDGNKPDDKTIRDIFYKIHDKMGHFSYSRTYPLVCEYLSYPGLSKDYSEYLRSCDVCKKVNPAVPVKIQKGLAVATRPLQIVSTDVLGPLISSENNFKFVLNIVDSLSRFIVLVPLHSTSGQEVWTKFRDEFIYSYGIPVIIISDGASYYLGENFTNGCAEFGIIHRVSRAGYHNDNTLSERSFKTLNDCLRKQLVDINHIRWPEFIKPIQFFMNNTVHKSLTTTPSQLFMGIKNRIMDMKNDKLYDVTMTPYIAEKSYEIAKLVLAEKNNFDYEKYDDKDRFFGLKCGGEPEKVSDCGNYKKKSSKILKNNPSKLSVGSEVLILESVKNKLNPKWKDGYVITKRSGTTVYVKQINGGRGRPLKRHITQVKPNWVRSSLEEDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSM3</accession>
    <name>A0A0N5BSM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BSM3"/>
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        <property type="protein sequence ID" value="SPAL_0000886500.2"/>
        <property type="gene ID" value="SPAL_0000886500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF1">
        <property type="entry name" value="SODIUM LEAK CHANNEL NALCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="410"/>
            <end position="432"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="527"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="566"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="981"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1052"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1239"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1424"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1462"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1546"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="132"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="494"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="1320"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1812"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1953"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1817"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1953"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1965"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1980"/>
            <end position="1990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000886500.2"/>
        </source>
    </evidence>
    <sequence length="2045" mass="234854" checksum="B2763BFB7907AA4C" modified="2015-12-09" version="1">MLKPDTYLIHHKTSSISANDPPITSSSKILAHKRSCILPAITTVTPGVLSFHSTSTTYGDNLSPNLLDKPTIQVNLRSSSNAKESFAAYYYTEMGNSDIGLSGSTILPSGDKAPEDGACNRNTNREFLHVTIMDYLLKISSMISMISVCLHTPQTLEIYPKLWYIIIIMDSFVTTIFTFEALLLIKQYNVIKPSPNTITSSNGLNKKKKYFTSKWRLFDFSLLLCHYISIFLDVLLFIENRFPNSGIIYKKWFSVLRSPRPFIMIRFIREIVSFKLPKNRIQQIIKRSSQQIQNVTIFFLFFMALYAIMGVQFFGRMEYHCVLPGTDPLNVTISDLAIPDTMCSIESGGYQCPPNMVCMKLQMNSHRQGFYGMFNDFASSLFTVYMAASQEGWVYVLYDCLDTFPSYIAFFYFVTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMWSTREKQSDDNYTQKLEKTDSGKWKLIENSDLTSHDSPCLMYKIVRSTYFQICIMALVLLNALINASFVHYHDESDAKRKIIYYYIEVFFTILFNIEFLLKVYALSWSGFVSRGQHKFEFILVIGSTFNVFPMLYGTNFFTYFQVFRLLRLIKASPMLEDFVYKIFGPGKKLGGLVIFTMVVLILTSAISLQLFCYVPKLDKFRTFPQAFMSMFQIITQEGWTDVVVEILRSTNESFVVFVAAYFVGYHLFVTLIVLSLFVAVILDNLEMDEELKKVKQLKAREETTCMRTTLPLRLRVFEKFPTRPQMVSLKKVSNEFPLPKIRDSFTRSFADEEIIAGSEDIEETWIGKSVKLLKCMGKIRSSVAGKIKMRQIGSTTKRTGLLQLLDSSNKSRMILSDSNQYLTGTKTFKSDSSSGKKTYGVGGHSIKINQIYEAMKENGDCRPTDSAPKNNLKQGEIDIRALQQKRAQAEFTRNRIEEEMRENHPFFDCPLFTVGRDSKLRQVCKKIVYAKYNSSQIDSLSGKSATTRYKQFHAFIGLMTYLDWYMVIVTSFSCYSMLFESPWPTTGENLIFNNPYLQVTEYIFILSMTIELAVKIIANGLFFTPNAVVRDVGGVMTLFIYITSLWYLFWMPSHVEMNSFPQLLMIFRALRPLRIYTLVPHIRRVVVELCKGFKEILLVTILLVLLMFIFASFGVQIVGGKLAACNDQTIKTRENCTGVFWQKVFVTRMEVYGKDSEELHPKILVPRVWTNPRNFNFDHIGNAMLALFETLSYKGWNVIRDIVGTRQGPWAVLFIHIYVFIGCMIGLTLFVGVVIANYMENRGTALLTVDQRRWHDLKARLRMAQPLHVPPKPAESARVRRRFYEWTMMKSFKQFFVILVLVNSATLVVPWNVDEEESQMNTLYLTTAISAICNILFTVEVLLKIVAYTLKGFWQSRRNKVDLIITICGLVWIIIHFMMATPAAKISQKTYLKHWTYSFGYIVAIARFFSIVGRKSTLKMLMLTVVMSMVRSLFIIAAMFLLVLFYAYTGVILFGMVKYGQAISKHVNFRSGKEALVVLFRCVTGEDWNDIMHDSQIWDFCYWRKGDDFWKSDCGNYYGAIIYFCSFYLIITYIVLNLLVAVIMENFSLFYSSEEDALLSYADIRNYQQVWNMIDVEQRGYIPVRRIKFLLRLLKGRLEVDTNKDRLLFKHMCYEMEKIHNGEDVTFHDILYMLSYRSVDIRKSLQLEELLQREELEYIITEDVAKRTIREWLEGCLRKSKQISSSAENPLIAQMRSTLIPQSSIGLQSTVTPSSLSPSINSELSTNVNDNSAINEKFQSKGGINLAFDDTVLSESSFITGPRLSLDKIKTPNILLQPRRSTFQNQLRRQKSKKRRSSIPELMGEAKKIVLGNVAGRMKSLSIHSTPQPSSSSASALLIDPSDGNRSSLIETSIDYSNNVNTSADNLPLHSNQSFNIYTNIKNKNISSSKHHYQIVMNLPTQSSSQNTSLSQHPVILSEALTEVEENSEEGLDENSVEKPRKDSLDVPNITYPTSTKSNRMNMDDETITSSQGKDLASLFLEDQIDPEEIKTWWGEFSKDDEMMEGNIYNTSNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSR4</accession>
    <name>A0A0N5BSR4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000890600.1">
        <property type="protein sequence ID" value="SPAL_0000890600.1"/>
        <property type="gene ID" value="SPAL_0000890600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000890600.1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4021" checksum="050229D9967B4402" modified="2015-12-09" version="1">XSKNAPPWPPWRNRLARSAVNRKVGGSSPPGGVDFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSV0</accession>
    <name>A0A0N5BSV0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COX6C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSV0"/>
    <dbReference type="WBParaSite" id="SPAL_0000894100.1">
        <property type="protein sequence ID" value="SPAL_0000894100.1"/>
        <property type="gene ID" value="SPAL_0000894100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000894100.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="13292" checksum="9AD2DDA404FBE5F3" modified="2015-12-09" version="1">MILWEWRRIYRQKIRSLFSTPKITYQEFARRKLFLGFGLFVVGWTFSGMFLEEKIMFRWDEMIGYKRLFDLKEVKELVKKENEENVAKRCDKEEKGESTLPPAFELDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BT89</accession>
    <name>A0A0N5BT89_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BT89"/>
    <dbReference type="STRING" id="174720.A0A0N5BT89"/>
    <dbReference type="WBParaSite" id="SPAL_0000907700.1">
        <property type="protein sequence ID" value="SPAL_0000907700.1"/>
        <property type="gene ID" value="SPAL_0000907700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000907700.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16569" checksum="51BA697C14019169" modified="2015-12-09" version="1">MALKRIQKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPAESPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRTQWSPALTISKVLLSICSLLCDPNPDDPLVPEIAKLYKSDREKYNQTGREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTI4</accession>
    <name>A0A0N5BTI4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTI4"/>
    <dbReference type="WBParaSite" id="SPAL_0000916700.1">
        <property type="protein sequence ID" value="SPAL_0000916700.1"/>
        <property type="gene ID" value="SPAL_0000916700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000916700.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63949" checksum="50F9B21B013CB1DF" modified="2015-12-09" version="1">MEDSDKGNILSELLEINLVRKQIIKHIPSFSDMNNLVDVCKFVRCDFEKEKIERSMFLNSDSQDIIITYKDEYDRASGVPAWSDFKFEKDSRSENRLNIVKTFFGETLLCGNRVEYFINLPEKKLKEKGRMSFIKKLVKELNLNCATRKDVKNLEFAFGKNIGYIVLDVLNHMKHDSITRISLPVNCFTCRPNKYNMINGNIFNGFPNLTELSLMCHFYSGDYYDFIHHKDTFEKFVQQFSTVKNPTIIFKFSNHDDVMEADGLFEIINILTKYNVKIKFNSTICCLNSELNCGICKNLMGFCLPIKQYITTAHSVILYHRQILHSIEIMETFENLCELHLKVILPLSNGNYMFSYNQKPGHMGLKKLSNLKNVKIEFSRSIFCRYSDILNSFYPFFEIICSMMPRSVEILQLIHVLDINDATAKMITEYMPNIKLLKISCLTYRESDGLDNFTKLECLISSEYCPIKIPKTLKVLAFKQTKYPFRSDDLILTDNLIKSHYENFTKRITCNDDWEHRYILFNDIHQWHLYKSTIQEYFCPYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVM7</accession>
    <name>A0A0N5BVM7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVM7"/>
    <dbReference type="WBParaSite" id="SPAL_0000988300.1">
        <property type="protein sequence ID" value="SPAL_0000988300.1"/>
        <property type="gene ID" value="SPAL_0000988300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36937:SF1">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36937">
        <property type="entry name" value="PROTEIN CBG20935-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894919" evidence="1">
        <location>
            <begin position="25"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000988300.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="60344" checksum="1422765C7005DAFA" modified="2015-12-09" version="1">MPRYYFFHYIFFSILYLSIICTDAQNYDPETQKLLKDFCNDLPMSIICRGKSFNEIRKAPTSRVNAKITPLAFGRSLGNDATFEVPGLGNIGVADTVSNIARFIPEGTENEVSNGGKFDVNDSGVKYTKSELATGRSNKHREFFKIAGIGTFDNTRKIEKGAGFDSLFKNIMPNIGENLEVIETTEKPKSIYDALELNKYINQYEGKIVYKPTLKDPFVNNNGRKEFPTLLSSNSNNLNDNSAKTVHQYKPLLKENVIHGTKIIKDPFNENNKTEVIDGSDNSDDDVMISSERILNPSNIPLSDLGLKKDQIFKLCSRFAPIAAKHCYSAKVEEAFIDKCRGYSRDCQQFIGENKPLGAIANLFNSGVGITMYNWGVNGIPFYAINEEGGIGNGHNGRADFGSWGGGWSENVGIRDFWTQTKEVGGNWYDGNYGYKTGWHVPIVQSLGIEGGSGTHIHVPVNEADLGNPIEVSNGYHVGPYIGLSEGIGVDWMNGGVSANQGFAIPFVGVNANSGTAIAFPSVGTFARMMGIATSPTYSKPIPIKNSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWU5</accession>
    <name>A0A0N5BWU5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cullin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWU5"/>
    <dbReference type="WBParaSite" id="SPAL_0001028366.1">
        <property type="protein sequence ID" value="SPAL_0001028366.1"/>
        <property type="gene ID" value="SPAL_0001028366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001028366.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8786" checksum="D58F86C9C98FA7D2" modified="2015-12-09" version="1">MCFFKFKKTSIWKTLVSKIDKICQDVFHQVLFSNHLLHKNEEDLSMLFVGWHTYMELYSLSIILLCYYQYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BX88</accession>
    <name>A0A0N5BX88_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BX88"/>
    <dbReference type="STRING" id="174720.A0A0N5BX88"/>
    <dbReference type="WBParaSite" id="SPAL_0001042100.1">
        <property type="protein sequence ID" value="SPAL_0001042100.1"/>
        <property type="gene ID" value="SPAL_0001042100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="17">
        <location>
            <begin position="10"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="18">
        <location>
            <begin position="86"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001042100.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57521" checksum="51F9B2DE4E92F852" modified="2015-12-09" version="1">MANNSKVANKVCLVVIDGWGVDSETHGNAIANAKTTTMDKLCSGNWTQIQAYGLHVGLPDGLMGNSEVGHLNIGAGRVVYQDIVRINMTVENDKFVENEYFLEIVNNAKNGNGRLHLCGLISDGGVHSHITHLFALVKAAKALKVPELYIHFFADGRDTLPHSGVGFMEDLQKFLAEQQYGELGTVVGRYYAMDRDNRWERIRVAYEALTVGTGEKADPSDAIKVMKERYAKDQTDEFLEPIVFGDNSRIKDGDSVIFFNYRADRMREITAAIGLNRDEEMKTNVKQPKVMLVGMTQYNVNYPFKALFPPVSHVNVLAETLAKQGVSQFHCAETEKYAHVTFFFNGGKEAQYENEERCMVPSPKVPTYDMLPEMSSAGVADKMIEKIREGKHPFIMCNFAPPDMVGHTGIYEAAVKACEATDIAIGRMYEECMKHGYILMVTADHGNAEKMISPEGGKFTAHTCAPVPFTCSSDKFVFKKQLPDRLMALRDVAPTVLYIMGLEIPKEMDGVPVVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY00</accession>
    <name>A0A0N5BY00_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001066300.1">
        <property type="protein sequence ID" value="SPAL_0001066300.1"/>
        <property type="gene ID" value="SPAL_0001066300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001066300.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18515" checksum="0E001DDC03F51094" modified="2015-12-09" version="1">XEQPNTYQEEYVEDEGSQCDEQFNMEEDIDVDGENDCQNFLNNEGDNQAHYDPQPLRMFRAVGNKEAVLLTKEETLQNINRLLNRYMNRLPVQIIIISHFMSGQDTYAFRSLVNNEYIRVDMNRDDMVVAELRPVVPEILYDPFRDERCIYGDRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ47</accession>
    <name>A0A0N5BZ47_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ47"/>
    <dbReference type="WBParaSite" id="SPAL_0001104300.1">
        <property type="protein sequence ID" value="SPAL_0001104300.1"/>
        <property type="gene ID" value="SPAL_0001104300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001104300.1"/>
        </source>
    </evidence>
    <sequence length="38" mass="4113" checksum="EE4AB976996AC765" modified="2015-12-09" version="1">STLSALLDNSIHEGICVGDKVETQFMKLSLVFDSGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C001</accession>
    <name>A0A0N5C001_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C001"/>
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        <property type="protein sequence ID" value="SPAL_0001133800.1"/>
        <property type="gene ID" value="SPAL_0001133800"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
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        <location>
            <begin position="478"/>
            <end position="733"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001133800.1"/>
        </source>
    </evidence>
    <sequence length="1198" mass="138516" checksum="646C154D96CCA599" modified="2015-12-09" version="1">MERWTEEELQIVEKILDQNSENLDYAKIKDEHFTKRTVPAIKKKILEIKKRKNNGTTARAATVWDKLESKKLLNAFVNTPGNLTKTQKCQLIQSDFPNRTIKAMQTHLRTHYLDIYMGYTTKVDESPEKNTSPIPRRPLSKIADQTPSTSKKKEITKKNVKVIDNKEPSLETSTIGSSETSMINNSKFDAQPPNPKEPKSQIEKIFLKYFNLVQTKKLKRLTKFVVQSFHQCKINAVSNLVKNKIASLEKEVKKLPRRHQLCKLAILAGGYTLKESCTKKNMAKKDKPSEILKRKISKLQARVKRTLRIQEGEKISLRLKSEIKEMKRLRMKPKQYISTTKHRIELLEKELAEAKERDEKWKLRFRAGNQPGLRNLNKFTKDDNSIDYIEAEKYFSELYSPFQPSTPETPYYNEWLNYIQDTCLTSEDENLSEAEIRHYVNQHLKTASNWKAGGWDQITNYLYKYIPAAKEYLIRHMTRIINGTYKLSRKDVQATCVLLHKGGSKEISNYRPLSLICTDIKCYTSIITQTIYDRLPSSIIPQEQLCQPKKWGTVEGLLRDKAYSGTARYRNVEQYSLWVDYRKAYDSICHKQMQRLINLLPIGPSMRNQLQHLTTILNTKLMDNESPNERQTISIKRGVMQGDVISPLLYILVSSSAVYQLKKNLPLKRLCKGNIQIITYMDDLKVFLPNESSLRAATELIEHSSAEIGLFLNSVKSGYFSRKNREDLEGFKIPKVVKYYKYLGILQTDHDVHENYEKLSEAVSKSVKKIFSSKLSFYQKCKLFNCSTIAAATYILGNITTKESVEATLAKARKLDLTIRKDLVSTNQKIRQVSNNRLYSYLCSVDSMKEPLQLLEQMQKGGLRTALSDWKYVKKLYKLPEPNFRSGLSYNEISKELISKVKKIDSDIKKKDWAKSMKYPQRVISTENIDFPGLKSLNLNTEHWRTLTAAGEEQLFLNAKCQSTNYNTKLEGKCRRCGELETSHHVVSMCKGHKYHQRHDIVIYHLLVKLAEKIKIQHSLQFGQATVSFKSEGVSIVAGAPYLSEKKLKFNRPDIICYLYDDGNNLKEIVVLEVAIPHLSQYVSSQKRKRIKYEVNSIDEVTDIEKPMRNLNLVSEIQNKEHRKTSLFILAIGTYGEVIYNEETNSTLHMLQEKFLMSNKEVQLLLTKMSYSVMCSSARILNSHLSDSHDRSYKNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C020</accession>
    <name>A0A0N5C020_STREA</name>
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        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C020"/>
    <dbReference type="WBParaSite" id="SPAL_0001135400.1">
        <property type="protein sequence ID" value="SPAL_0001135400.1"/>
        <property type="gene ID" value="SPAL_0001135400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001135400.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36921" checksum="D95C7704E3622D42" modified="2015-12-09" version="1">MDPSMVPTYIRPYFGISGYQVSIISLLSIPPNIYFFYRCLTYSKFKERQFFRYMVMIMSFEFICASILHLIFYLYISINYYTHNEVNVKTCSKLESIHYSTNTILNLTFLYLSIIRFYKIVYNEKPNIIFMGLTVLFTMGPFLYILIAKHFEIDIYFVPRQGCGYDIYSKIFYYKYISYGNILMNLIYSLLSLIINYVIYRIVVKKTLVSNKPKMNDNKSVFWSVAIQCLFPFCYQVPATIYYFVFSIIQGKKVTEIEIFLNLLFYSGHLLSIFLSLVVIKHFKIMMLNDFGCKSITDSIPVTRVHAKSMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C098</accession>
    <name>A0A0N5C098_STREA</name>
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        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit BLS1</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C098"/>
    <dbReference type="WBParaSite" id="SPAL_0001142775.1">
        <property type="protein sequence ID" value="SPAL_0001142775.1"/>
        <property type="gene ID" value="SPAL_0001142775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001142775.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11131" checksum="AE6281AFC4570EE8" modified="2015-12-09" version="1">MTEEIKEESSFIDSNFSPELVNSLKNLSNENRQLVFEELGKKFFKCLNEINNSVELGTTVVQENIFDLQKYLLSEISDIKKSLCLLNAKLDLLLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0H2</accession>
    <name>A0A0N5C0H2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intermediate filament protein A</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0H2"/>
    <dbReference type="STRING" id="174720.A0A0N5C0H2"/>
    <dbReference type="WBParaSite" id="SPAL_0001150000.1">
        <property type="protein sequence ID" value="SPAL_0001150000.1"/>
        <property type="gene ID" value="SPAL_0001150000"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000016">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1260:FF:000003">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016451">
        <property type="entry name" value="Intermed_filament_ifa/ifb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF6">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005546">
        <property type="entry name" value="Intermed_filamnt_Ifb-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="77"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="7">
        <location>
            <begin position="462"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="334"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001150000.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="67307" checksum="3665198792725CFB" modified="2015-12-09" version="1">MAQKESSDYEIQYRSTIQPRTAVRSQTRQSGSYSTGSGGGGRVLKMVTEMGSASIAGISPALSANAAQSFLEATNKEKKEMQGLNDRLGNYIDRVKKLEEQNRELVANLEELRGRWGKDTSEIKIKFSDSLASARKDIDDAARRKAEIDVKVSRLRDDLAEYRSRYEDIQHRRETDQEKITQWNHAIADAQNELSMLRARWKQLTDEEKRLANDNLRLRDELIKARNDLDEETLGRIDFQNQVQTLMEELEFLRRVHEQEVKELQALLAQAPADTREFFKNELALAIRDIKDEYDYIAKQGKQDMESWYKLKVSEVQGSANRTVMESNYQREEIKRMRDNIGDLRSKLSDLEGKNSLLEKEVQNLNYQLNDDQRQYEQALNDRDSNLRRMREECQTLVAELQALLDTKQMLDAEIAIYRKMLEGEESRVGLRQMVEQVVKTHSLQQQEDTDSTRNVRGEVQTRTTFQRAAKGNITIPECDANGKFIVLENTHRNKEEDISECKLKRKLDNRPDIVYTFPSNIILKPGQTIKIYAKGQGPHNPPHSLVFEGENTWGVGANVVTTFLNKDGEERATHTQRTVQTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C0I3</accession>
    <name>A0A0N5C0I3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C0I3"/>
    <dbReference type="STRING" id="174720.A0A0N5C0I3"/>
    <dbReference type="WBParaSite" id="SPAL_0001151100.1">
        <property type="protein sequence ID" value="SPAL_0001151100.1"/>
        <property type="gene ID" value="SPAL_0001151100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46068">
        <property type="entry name" value="PROTEIN CBG27172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46068:SF1">
        <property type="entry name" value="TRANSPOSASE IS30-LIKE HTH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895250" evidence="2">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4817" evidence="3">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001151100.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17880" checksum="63B5E008C838E3A8" modified="2015-12-09" version="1">MVKLTTYNFLIFSLFLSVVIKTSESYSISERIKIVELYYANKCSASLTQKAYRKHFNVGTAPSSSTIRNMVKRFEERGSVKDLRRSGRSRTGTSDENALLVRESLNENNQLSVRRRAKELCIPRTTLARIINQELYLFPYKMQVAQRIEATDNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1A8</accession>
    <name>A0A0N5C1A8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein rotund</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1A8"/>
    <dbReference type="STRING" id="174720.A0A0N5C1A8"/>
    <dbReference type="WBParaSite" id="SPAL_0001178500.1">
        <property type="protein sequence ID" value="SPAL_0001178500.1"/>
        <property type="gene ID" value="SPAL_0001178500"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein rotund"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001178500.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33509" checksum="011CA82A0CFD499E" modified="2015-12-09" version="1">MSQTVDPFFCFQLPFDRPKQENQPTMREAKPYKCQQCTKSFANNSYLSQHLRIHSGVKPFGPCKFCGKSFTQLSHLQQHLRTHTGEKPYRCKIEGCGKAFSQLSNLQSHSRCHEQNKPFRCNSCYKCFSEESQLLEHIPKHQDSKHLKKHLCRFCGKSYAQAVYLEKHMAKHSDRRGNITGQVDHVHSWSQQFNNAGDFLRLGQSANAAFNRTQEQLAHATASQSNLGSANLGGPSIASSTYNTYQTTTPTLVAAAAANSAMMNQPTIPLDLFNGPAFNIITPLEKINQTYNNGGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1F6</accession>
    <name>A0A0N5C1F6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1F6"/>
    <dbReference type="WBParaSite" id="SPAL_0001183100.1">
        <property type="protein sequence ID" value="SPAL_0001183100.1"/>
        <property type="gene ID" value="SPAL_0001183100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001183100.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13412" checksum="49CECD79FB20230B" modified="2015-12-09" version="1">MIEVTNNNVSHQTYNKNFIINNPEWDCRNKYLKKLMTSSIKSYSPNVDEIQRHITETLEDYLKTSNSSWLIMVGKVVRSVSYIDYEVKDTEWFCSVYDNTSNIQIHAIRVYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1J0</accession>
    <name>A0A0N5C1J0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Foie-gras_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NIBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1J0"/>
    <dbReference type="STRING" id="174720.A0A0N5C1J0"/>
    <dbReference type="WBParaSite" id="SPAL_0001186300.1">
        <property type="protein sequence ID" value="SPAL_0001186300.1"/>
        <property type="gene ID" value="SPAL_0001186300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="4">
        <location>
            <begin position="601"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001186300.1"/>
        </source>
    </evidence>
    <sequence length="1194" mass="135700" checksum="94A7514613B75729" modified="2015-12-09" version="1">MKINSLRIAPGFPGLEDHQQIQILVVNLGEDILIGGESSFYKLLNRLNDHSVKKVGDQEPHYVYIKFVTQNDPLNLKFANLQVYRRIFAVIGVAFLNEKNNISEIYERYKNIKKNCDEDALVDNRLLIFGGEKQEIDGENLREIIYYESFKEAPTFNYDIQGLLKNVIIILQSKRLEDTNEVKRCPLLSGEEKYQVGLDKQSKSYKKKCIGRLKKQVGDLHMLLGLPAKAVDIYNTAIENLKSANDLLWLAAAYEGLAVASYYSLIGNEPLIEGKKNTVQRNHTINDFDAKDSDGSYKSIRRHSRRNSDESTKSLNTSSDERVKFKGFLKNIGKLTIGNRGFLDIPSIMDKFIQSIENFERFSYSAKIEYQCVIKAASLLFWEHDYIRCEAFLREHIGKYLDDSFVTFNNFEKSSICVDCSIIFKEMNFKRKHAFFSRLAVLFRLHVSDEEPRTENDYKNVYPLLYNTLTGYGIQLKSPLDINKKEANSNISGPSQIQVKAIQEVFMSSLRGGLVHSSIRHLCFLLQNYYELLDQKAIDSMLEELKKLTNKLEDKHNLNQIIQLDYCNVLIPAVQWTRFPKIIGVELKPLKNNLDINIITKSGGYGDIFIYSPFQQDHGNVKIYWSVDCSSTVTLKIVNCFHFELAVSNLILLVDGCDFESIPVKLHLPPTIRGQNEKFVDVDIQGFPHSEGTLKFVGYSCEVLGVKNVVKFNNEQFIKTVRVLPKLPMLEVDTTLEKESLKEGSHYETETEVSLFSGQSFNHTITITNKSEDISIKNIRVKIQQPKISGGPQLISIVESCTKDFILLPKESKDIKITIYGIDPTTAPESNGETFPASSLFSKHIPDNISILSSTSNLLLSELEEQTSHDLIPYTGRLLNATIKITYAADLENENNEIYERCYSIGVTIKIVPAITISNWHVLSGEDASTRYIVLDVNNLTDYDAELNYLHDKELSVQAKDTCRVLLLCSCCGEISPFAFSHASQRPSFHMQKEEIEKLRRILEDHVSSHLNIRWSIPKLNINGNVPVGSLLSSVSCLKQLVVPLLTVTLSINKKPYTSEDDIIVNIGDIITFNITLMVSTKASFDFSGTISLLCFHDLQNGEEHIYVPESLISIGSVVVPFNVKTQESDGLVRVAFKKDFNFMFRYEGIYKVKPSIFLDKCDNLEEQKLLEFAEKEFFISTASFNVTTKSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4H6</accession>
    <name>A0A0N5C4H6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dimer_Tnp_hAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4H6"/>
    <dbReference type="WBParaSite" id="SPAL_0001285800.1">
        <property type="protein sequence ID" value="SPAL_0001285800.1"/>
        <property type="gene ID" value="SPAL_0001285800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="469"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001285800.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="62612" checksum="6DE2533A8B7EC334" modified="2015-12-09" version="1">MFSNKEFKFFNNSLPSASTVQRYVKDLANEAYAKLQDGLEDYNFVLSFDGYKFQQRKMLSVVIFKSNGFDVEKWETVVFPVSSKFTDIAAAISNEINKVPFLITCDGAASCLKAARILLSKNKVRPLHCSAHAFHLVVTQAIDKSPYQCIKNLFSRARGIAASFRRTENSLKKRLRMPIDVRWNSYLHCFESILENKDEINKYAVENSPKLFLKKSEIAVFEKICEILKIIEVASMSCCNNKCQLYEMTFYIRNALFKLFQLKNNEDEIYKDLIGVTSIEEEDEEDHDDNCGDSSKDEDYQVDEAEYSDSGDSDFENDTDLEIMDLEIDMVENKLDELTDENINNLLNMEVGDSANDKEALLNFIDNLMGNICTRFKSHFNHPFVNLSLFLCPGMVNIEKVIDVKQVEKYIIKNCSKYLSHLNNNNERYDDVPEIFKNFEFIKVSSDDKEEPLLVNQIKIEVKHFKFLSSTSKLKFREFWEKHGNELIHLKQLVVKIFTCQVTSASCERLNSFFKRRLLSRPRLSNNQPRSETLVSRNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5C4</accession>
    <name>A0A0N5C5C4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BMERB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5C4"/>
    <dbReference type="STRING" id="174720.A0A0N5C5C4"/>
    <dbReference type="WBParaSite" id="SPAL_0001315300.1">
        <property type="protein sequence ID" value="SPAL_0001315300.1"/>
        <property type="gene ID" value="SPAL_0001315300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001315300.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="63471" checksum="2880FDEEDB092CBB" modified="2015-12-09" version="1">MQKISSWFEDHLPLRRRRSYARRSDSSKKGSYGKSSKSATPAYRITPSNDMSQSCFEGYPSNYPPKTLCNNYTCCCHQDLNNIIISDRYSSQQYVEHHKNLQQKNENKFDCRMTTSFAGVSLNGSKNFCRPLPNRNDEKLEDEDEYILSPIPLPKGCYSRNRYIYPSFSSKNMSQSMIHNTSSSLGYSNTLHTTASFRQSIRTNPWINRPKPTILGNNNIFVGQQSSNHINKTINGQLNKNMIIEGEKNKLSNANVIKKPNLEMLYASMDRGASLRVKSLDESTCSSGYGSQDSSPESSVHSPNWQQSLKTEIKQSDSQTSGLLTGSESEFTLYAASRLKQISNNMDGKNSTNSSCLINYPLCNKDESFTSGISSGYSDEPIYHELEIIKRLSMLEVDEDSEEFGGCCSDTELLMMDTASSSSFDCSSPIYAVPFDGDSTRTSKNKSFYDDDEPIYADVVSLKIASERDTPSPQPIIDEKAHLETAKQIAATSKAEFEFLEQLDRQIADLQQQSEAMRKLVEEARERDEIRQKNRQICLKEISQLRNMKWIVRNNFELCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C628</accession>
    <name>A0A0N5C628_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C628"/>
    <dbReference type="WBParaSite" id="SPAL_0001340300.1">
        <property type="protein sequence ID" value="SPAL_0001340300.1"/>
        <property type="gene ID" value="SPAL_0001340300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001340300.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="68718" checksum="BC0D140883F5F5BF" modified="2015-12-09" version="1">MARTSNESFEENMFEVCMRERRINGNISQDEKIDKLGKLITGKLVNYISDNCFNEKQINGLIKLITGICIDSGIKELQMVAPYIEFEGIEKFEDTGCQTFTLPAECNIKRKKMKNPDTSAYVIDFQKDIKNYLSSLKIPISIDKIDLLLYGDDITVSQPLGPSRRQNSFTHMAYRVMNLDIIKSSSLYHYRTLAIAYTKYAKQDRYESLIKQCIELINSTTIDIDGKKIPVGVKLVVGDNVFLNCALKAPLIFTNRGRNNCRTCTVSGPDWVKYKTPNEVKKYVRIKHFVSHIPVDNHLISDPFHDVLTGVLNYVLSGCVNVFLSLTKRTVSEDDLIKLILEQADIFNRQNEIRTLMYTGIFKALKCTGKRRLNLSGSQILLISRCFYTILTTNTWPNLDGSTIIKLDEIKLLLETSLNLAYGTTDHTTDVLELAEIFHKNTEKLFELLFKLFGQNFSITAKMHNLLHYSYCIEKLKLRPAEYSTIRFESSNIRIKKILVNTKCRINPCKTVIKRINFLNDLSFKYKHTIQEKNIEISNVWNYTNVQVPETGLQVDDPVEQNVLETSSFLLEYIEDNETFSDESEPDDDPMDFTYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C682</accession>
    <name>A0A0N5C682_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C682"/>
    <dbReference type="STRING" id="174720.A0A0N5C682"/>
    <dbReference type="WBParaSite" id="SPAL_0001345600.1">
        <property type="protein sequence ID" value="SPAL_0001345600.1"/>
        <property type="gene ID" value="SPAL_0001345600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="5">
        <location>
            <begin position="125"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001345600.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48132" checksum="3556529A24959EC4" modified="2015-12-09" version="1">MRTNQLQTKLKPKTMSLEIEGLKKATEKNELKKATEKNERLMSELKWIRGDVTQRISNEIKNSKRDTNSIEVKFKMFSRKKILRVGKGEPIGKVDGTKVYFHYEVYLPDKIYSGDEFPSDPSLYTCIDSTRRSWPKGFGREMEIVIGKKFQLEFFEYALSTMKSGEVAFFDAAPNIIANYATVASRLRNMVKSNSDSKTSPEPYVGSCCGAQLKNGTGYPELDKWNESPIALRFKFEITKIFTPGSYTQDDWQLEDSAKLSRAESLRLEGNGLVTQKKYEEAIERYGRALTLIDQVLLKETPKTPEYTAIDMLNVPLYSNLSLCFLKLNKTRDCIKTATEALKRDPKCEKALYRRAEGYINEWQLQEAESDLEALKNISPDNLQLYKIGMGKVGEARIKHQKTQAKYAKKMFPNANINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6B8</accession>
    <name>A0A0N5C6B8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6B8"/>
    <dbReference type="WBParaSite" id="SPAL_0001348900.1">
        <property type="protein sequence ID" value="SPAL_0001348900.1"/>
        <property type="gene ID" value="SPAL_0001348900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001348900.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24242" checksum="281878D3B580B98B" modified="2015-12-09" version="1">MSSSKNGNSNALNVQLDASKKLRNSKPTLPYLIKPKVKLIVSLMFVKVCLLYFCERKQICLYYDKKNIQNEVDLNNSKRIVFDTEQFLSLPGQDDMSKKSGDIVSDASESHLSSSNKKTVKDYAKTPVTLTSDNDGCGEFTEVPLKSKDKKKEPRKLLSEPNLDKLLARTKKYRSACLNFFRDPNNSKRVVYGKSENKMSPVKIINNRFEVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6J4</accession>
    <name>A0A0N5C6J4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7583 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6J4"/>
    <dbReference type="WBParaSite" id="SPAL_0001356000.1">
        <property type="protein sequence ID" value="SPAL_0001356000.1"/>
        <property type="gene ID" value="SPAL_0001356000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056005">
        <property type="entry name" value="DUF7583"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24486">
        <property type="entry name" value="DUF7583"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7583" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7583" evidence="1">
        <location>
            <begin position="153"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001356000.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32666" checksum="B06FD24DA738D219" modified="2015-12-09" version="1">MLFNDESVEADYLQNTVSKSKDNFQLEEGFVYFKGNNPKGKCTCVYKLQVGEIKTFQEYQSIEDTTLPDVKYAYDQLNFHPNCSREENTYTQLKTIKLNDKRIEVEGLNDAELSQLGNLKPTKNLLFYIVQNPEGKFSCIYKVPIGEIEKSQNYQPISNETHPVVEYSYNDLGYNANCSRHLNSFTHLRGIQFKDDKTTVLSLQRSRVGALGRLKLEKDYVINTEKNPNGTLRCLYDVPIGEIWVTKNFTTYRTGDEENSSNEIGVMSSMILGCMIIISMMISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6W1</accession>
    <name>A0A0N5C6W1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6W1"/>
    <dbReference type="STRING" id="174720.A0A0N5C6W1"/>
    <dbReference type="WBParaSite" id="SPAL_0001367600.1">
        <property type="protein sequence ID" value="SPAL_0001367600.1"/>
        <property type="gene ID" value="SPAL_0001367600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="138"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="2">
        <location>
            <begin position="565"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001367600.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="70011" checksum="11C7D4BF4BD91605" modified="2015-12-09" version="1">MDNSGEANNIKEIFADGLSDIPSDEENSDDCEDDYDFQVLQDNAKVMIPLDEEENDDYESSDIENVVPEKKRKVLIPSNSESNVNELSIISLPSGRGLNSDDDDWSTEDVQPKLEDFEGSCGVTVAISEPNSIPEVVKLILGDDLFEMFSHQTSVYYNQNSKKHKIAKTIKWSPVNPTEFKKFLALIILMGRTQKGSWREYWSTDPLLAVPIFPKIMSRNRFEQIWTFWHFNNNEEMTNSSSRLFKIQPVLEYFVHKFNTVYKPKQNLSLDEGMIPWRGRLSFRTYNPGKIVKYGLLVRILSESDTGYICNLEIYTADGKKLEETILSVLEPYLGLWHHVYQDNYYNSISIANKLLEHKTRVCGTIREKRGLPLCLKNEGSLLKSGEIAFRRKGDVLLLIWMNKRQVRMITTIHDSSYCSIGKKSKNTGEEIKKPICVHQYNANMKGVDRADQHLSYNSILRKSVKWTKKAVLYLINCGLFNAYRIYQTLNPDSKIRYKDFLLEVARNWLTLGETEESTVLESSLPGLSNITKRTPSKDYPQRLSGDMKKHVPVQIPPTEKKEFPTKRCKVCSTNGKRSETRYVCKICDVPLHTVDCFTRYHTLKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7C9</accession>
    <name>A0A0N5C7C9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7C9"/>
    <dbReference type="STRING" id="174720.A0A0N5C7C9"/>
    <dbReference type="WBParaSite" id="SPAL_0001384300.1">
        <property type="protein sequence ID" value="SPAL_0001384300.1"/>
        <property type="gene ID" value="SPAL_0001384300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="35"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001384300.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="40729" checksum="DCB6BA8E8F89121C" modified="2015-12-09" version="1">MISSRTFSASSRLPSILRRTFVTDSVQKGLDVSTKVNAVLIPGDGIGPTLAESVQEVILRKNIPLQFEELNISGAKYDPSKTVEYVERILRENNNVALKGTILEPVDDLTFNELQGLNLKLKKGLDLFANVAFIKTMDGIKTRHGKELDFVIIREQTEGEYSAIEHESVPGVVECLKISTRSKIERIAKFAFDFAVKNNRKKVTCVHKANIMKLGDGLFLNTCKQMAQKYPGIEFEGMIVDNTCMQLVSKPEQFDVMVMPNLYGNIIDNLAAGLVGGAGVVPSYSIGSEFVLFEPGSRHTYAKGVGRNVANPTAMFLATSKLLNHLHLTVFGEALRKGVEKTIKSGKVTKDLGGNASTTEFTEAVIQNIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7D4</accession>
    <name>A0A0N5C7D4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransfer_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7D4"/>
    <dbReference type="WBParaSite" id="SPAL_0001384800.2">
        <property type="protein sequence ID" value="SPAL_0001384800.2"/>
        <property type="gene ID" value="SPAL_0001384800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001384800.2"/>
        </source>
    </evidence>
    <sequence length="331" mass="39835" checksum="AF8A032892371DF9" modified="2015-12-09" version="1">MKTSIFIILSSIYYFLICFRRCNTITTTTTLISTTANIYEGNISTELIVPNHKFTECDNNKEWKRCSKVIKLRKQEFYVSPSDKLSVCVIQKNFSSMMIAIMCYLFSEKRFRRKNNHLADNRWNNKECTKHNFANSTWRVIKYFNRGRKKNFYKNWKSIIIIREPIERFISGYMHHCSKDGGKFRKTSSCFYCNGNLNCFLLNLYKIVTSSSKKNIFNADRHLNQHFFPQTWRCEYSQQKKNYHILRYSSKNTTIFYDEFIELLQERNVKQKKIAFINYEIRTTKSHHSTSGKISTEKLRKQIYSNNKYLELLVRIYYADYIEFDFPFPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7W8</accession>
    <name>A0A0N5C7W8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporozoite invasion-associated protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0001403000.1">
        <property type="protein sequence ID" value="SPAL_0001403000.1"/>
        <property type="gene ID" value="SPAL_0001403000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001403000.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42487" checksum="D54A654FEE5006D8" modified="2015-12-09" version="1">XDAKEESTVKADDDDDPSDNVPPIKEYDESIGRMATDDEMKILCYQVRNMGECFENTQVLNNSKDDDQCMMIKNVDARRFVESIGYQYNCFIENDMKRYSIPPCEKKSVDLRHVEILKINKRFCESKFDRYGINSYAKNDNGSIVGNDKGSGSPNQQRCLMNVRQSKFGRDYPNISKSERIKRNTRMSQYESSENESYRRFEETRQYPVYPQYGSYRHMPMMPVYNSNVKIDVYDPNESFKLFYERFESMLLLNGVPSHLKLPMLKLHLKGRVANDVQTQREIKNDYKRLVDYLKRNYTGEESIAAARHKLSSLKINRSVDLINVGNEISRLIDVIYVEESHEDRLRRKRRHLAELLPVGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C882</accession>
    <name>A0A0N5C882_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C882"/>
    <dbReference type="STRING" id="174720.A0A0N5C882"/>
    <dbReference type="WBParaSite" id="SPAL_0001413800.1">
        <property type="protein sequence ID" value="SPAL_0001413800.1"/>
        <property type="gene ID" value="SPAL_0001413800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="145"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="246"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001413800.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37987" checksum="934F28D8E6BA4878" modified="2015-12-09" version="1">MVYKDNMIHFISGGLGSGVGLLVTYPLDLIRIRLQSGIGIKGESYHGNKLKDTILQNNIAKYNLGKTPSTTSSFHVPIVTNVYKQLFDLHIIKNVKQIIINEGVRGLYKGLGASVIAFIPTKAVYFFYYNAAKSEINKGKYFTPNTAPVHMFSAGFAGLSVCLIFNPIHVIKTRLQLNSGNMNVRECLSYTFKHHGIRGFYRGMEASAYGVSEMVIQFMIYEKIKHDLHNWLSTYNVPLYWLSEDPKVAHFMVAGAISKFTAVVTTYPHEVIRTRTREVGYKGQGFWTLMNQIRKNEGFKALYRGMGTTLIRSVPNSAIALTAYEYFVKFFNKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8A0</accession>
    <name>A0A0N5C8A0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8A0"/>
    <dbReference type="STRING" id="174720.A0A0N5C8A0"/>
    <dbReference type="WBParaSite" id="SPAL_0001415200.1">
        <property type="protein sequence ID" value="SPAL_0001415200.1"/>
        <property type="gene ID" value="SPAL_0001415200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001415200.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10335" checksum="33A6AEB41A8D2207" modified="2015-12-09" version="1">MPKYYCDYCDAYLTHDSPSVRKTHNGGRKHKENVKNYYQKFLEECQQKMLEAQAKNFQKRVPGAVVQTAPFPIQPMRFYCIVRNPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8J3</accession>
    <name>A0A0N5C8J3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8J3"/>
    <dbReference type="STRING" id="174720.A0A0N5C8J3"/>
    <dbReference type="WBParaSite" id="SPAL_0001423900.1">
        <property type="protein sequence ID" value="SPAL_0001423900.1"/>
        <property type="gene ID" value="SPAL_0001423900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000016">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001423900.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40796" checksum="29CE99324101280B" modified="2015-12-09" version="1">MGILEKISDIEKEISRTQVNKRTEMHLGFLKAKLAKLRSELLEPTSKNGPKGVGFDVTKSGDARCALIGFPSVGKSTFLSTVTKTESAVAAYAFTTLTAIPGKIEYNGANIQLLDLPGIIEGAAQGKGRGRQVIATCKSADLVIMMLDAHKGEIQKELLTRELESAGIRLNQRPPDVYYKQKKIGGIRFNKTVPLTKINEKMVVTILHSYKIFNADVVFREDASVDEFIDVVLGNRVYMKCLYVYNKIDSVSLEEVNRLARQPHSVVISCNLKLNLDYLLEKIWEYLALIRVFTKKPGNPPDLGPEDGIILRGSSTVENCCQSLHRALVSEFKYAIVWGTSTKFSPQRVGLNHKLDHEDVIQIMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C8P3</accession>
    <name>A0A0N5C8P3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C8P3"/>
    <dbReference type="STRING" id="174720.A0A0N5C8P3"/>
    <dbReference type="WBParaSite" id="SPAL_0001428300.1">
        <property type="protein sequence ID" value="SPAL_0001428300.1"/>
        <property type="gene ID" value="SPAL_0001428300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040019">
        <property type="term" value="P:positive regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="140"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001428300.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="58020" checksum="90496912661B7619" modified="2015-12-09" version="1">MFIILSFSYLINFFTEQRKRPNLYETDEDEIPIKTPKNENSQSSLEKKILELYSEDENSDTDTHRITSPMSDNNISNNDDESVDIEYLRSLDYDELSESQKKFFSQEELEEMEKDYQKKLIASLPVYYAGISGCRSVEEYKTLNRIQEGTFGVVFRAQCKRTDEIVAMKKLKMDKEKDGFPITSIREINMLLKCGSHPNIVNVKEIVVGDNMDSIYMVMEYVEHDMKSLLDYLAQRNKHFTISQVKCLMKQLLAGLEHLHSEWILHRDLKTSNLLMNHRGILKIGDFGLAREYGDPLERYTSIVVTLWYRSPELLLGVKYYSTAIDMWSTGCIFAEFLTLKPLFPGRGEPEQITKIYDILGTPTEKMWPGYSNLPLVKKWSLPNRSYNQLKSKIGDKSLTEKGYKLLNKFLTYDPEKRITAEEALKHEWFDEAPYAVTSDCMPTWPAKSELSRVPKESHKKPPNVKISRTSEELALLKGLNVNPNNVKSSGFSLRFDAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9E3</accession>
    <name>A0A0N5C9E3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NDNF_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9E3"/>
    <dbReference type="WBParaSite" id="SPAL_0001452700.1">
        <property type="protein sequence ID" value="SPAL_0001452700.1"/>
        <property type="gene ID" value="SPAL_0001452700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019326">
        <property type="entry name" value="NDNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045805">
        <property type="entry name" value="NDNF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056225">
        <property type="entry name" value="NDNF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619">
        <property type="entry name" value="NEURON-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619:SF3">
        <property type="entry name" value="PROTEIN NDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19433">
        <property type="entry name" value="NDNF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24354">
        <property type="entry name" value="NDNF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Neuron-derived neurotrophic factor N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Protein NDNF C-terminal" evidence="4">
        <location>
            <begin position="403"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001452700.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="68733" checksum="F6AE7555088B9A74" modified="2015-12-09" version="1">MNSVSFLDMMGRIESNLPLPKKNKHQRSNDESQNKHFNVLIHGMKHRLHFNKYGNNQIYQIYMPGKDYPFWMYITPCDCTLHWQLYMRNEFDNKDPIYTTTIDSDYNKKLNMESNLYVHVERNLRDANLILLAGQSGNKRMKFYAKDIESDLLFLNVTSYDCSSFEVLFTTVERQIDEFYAPLPDDTTLHYEVFPHKYDKNTIEKNDVNLVDINLSWEFDPKFEPFKYKHCAVLTRNFMKPSTCLDNRMPLEKMYCNVESNNNMTIEKIKIEKNMQILLYVFDLHMGSINVFPPLQINRTDMKFEEPYKDIFIGNDEGVPRMKTTTTTKLATVTIPPRITLPDGILYEASFQKNDGISQNFNYFVQPSLNKGNDSGKILLILNACSGYIRLSIFKGEVLLRNTEEITGFRRFLIMNVHEGSLRFEITNLDNESKKYKIWVSGRPTKSPYPQLPSEPSLKIVHRTCKTVTIQWYKAIDKKINYCMYRYPLNDTDLTNISFKSDPNIDYCYPKLSKKNIIGCYTSYGVEKDVYNPKGITSNSLIEATLEELIPNQVYKFEMFATKKVGKKSYHLPYRALIAKTMENCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C9H3</accession>
    <name>A0A0N5C9H3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C9H3"/>
    <dbReference type="WBParaSite" id="SPAL_0001455700.1">
        <property type="protein sequence ID" value="SPAL_0001455700.1"/>
        <property type="gene ID" value="SPAL_0001455700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001455700.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14020" checksum="6420B7FB17ADAB72" modified="2015-12-09" version="1">MVKHLQKFTINISSYQFGFRPNFVITDCIKTFENVMEKLYEYKIPAQLCSIDHKEAFDRIYRKIAWIAMEKLKVEEELIEIFEALSNNNKMIFIGISGKKIGVEVVIGASKDVHLLQLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAR2</accession>
    <name>A0A0N5CAR2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAR2"/>
    <dbReference type="WBParaSite" id="SPAL_0001498100.1">
        <property type="protein sequence ID" value="SPAL_0001498100.1"/>
        <property type="gene ID" value="SPAL_0001498100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001498100.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11942" checksum="B7A956FED1184C36" modified="2015-12-09" version="1">MSDAAKNAQKQIDQISSNESLSKNDKKSQIRQIESSLTQTVLNELENFEDGRMNPTSSGYLVGTVNNGLRNFGNSRKKIFDFDFDDIYEIAKRSINKSASRGGRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CAY0</accession>
    <name>A0A0N5CAY0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CAY0"/>
    <dbReference type="WBParaSite" id="SPAL_0001504600.1">
        <property type="protein sequence ID" value="SPAL_0001504600.1"/>
        <property type="gene ID" value="SPAL_0001504600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001504600.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15782" checksum="1833FE3268328D05" modified="2015-12-09" version="1">MNLEGDSEGKIHILTNARPKYSTASHASTSSSINQYFANIPNIDASKTEYVNTGLYSNLTGIEKRKSSRFESSFMSRKRSMKACLAEIESHTNNNINGDNELKYHLRKLSPAVYRIPKKSYSDKKSIASNRIDLLGGALIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CC06</accession>
    <name>A0A0N5CC06_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spindle and kinetochore-associated protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CC06"/>
    <dbReference type="WBParaSite" id="SPAL_0001541500.1">
        <property type="protein sequence ID" value="SPAL_0001541500.1"/>
        <property type="gene ID" value="SPAL_0001541500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001541500.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31819" checksum="2756B2EB9A847DCB" modified="2015-12-09" version="1">MTKEASDGIFKKEINWCNKLNRSIINCKVIVGNILYEIVTMRDNIDKCLESFTKLTEILKKMESLNSERLKVMESFMEACSSGDSENVGTDPNPPPKGTEVKIEGYRDIEKQLTPVSSKLSSLSFSESAVGSSKMPLTIVDETSEKSISPDYNLDDSKSEWSEDIYHQCGDVKLYIHHKGSNKIRLGKVTYTFKEYQEKKLLQVKCSQLKDIRDIFFDCVTDSENFHLYYRNDYAIIKIKPSAVTGCSPVIKSYVLKFDSKAEGSSVYHHILRKPFSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCI5</accession>
    <name>A0A0N5CCI5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein on ecdysone puffs</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCI5"/>
    <dbReference type="WBParaSite" id="SPAL_0001559200.1">
        <property type="protein sequence ID" value="SPAL_0001559200.1"/>
        <property type="gene ID" value="SPAL_0001559200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001559200.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15953" checksum="DA30A8355223CE3C" modified="2015-12-09" version="1">MIMETWEEVVSQNGPGGGVNNNNMQGNGQGMGGGMNPNMNNGMMNNGMMNNGMRPPMMPKQPSNPGLFRRMFRGRNPNNQGSNILKNCFNKKHLGNPYGPSNGPPGPNMNGGYNGGGNFRDGSFRGGNNFNGRGANFNRRGSFDDYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCN3</accession>
    <name>A0A0N5CCN3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5CCN3"/>
    <dbReference type="WBParaSite" id="SPAL_0001563500.1">
        <property type="protein sequence ID" value="SPAL_0001563500.1"/>
        <property type="gene ID" value="SPAL_0001563500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001563500.1"/>
        </source>
    </evidence>
    <sequence length="973" mass="108236" checksum="BB7C6FCF0E2FF091" modified="2015-12-09" version="1">XNNKVVEMDPNVINLRLPSTRTNSQKGQENDDNNSVFAHADGGNSRDHSPSHHSSRSNDGRSNVSAYASGREGMFSNEGVGGGPTGRHPDPQLNVGGGPTNRGRNTLPVVGGGPTDQRVNELPVVEGGSTGQRVNASYDTPKEEFLMRLRNNKVVEMDPNVINLRLPSTRTNSQNGQENDDNNSVFAHADGGNSRDHSPSHHSSRSNDGRSNVSAYASGREGMFSNEGVGGGPTGQHPNPQLNVGGGPTDRGRNTLPVVGGGPTDQRVNELPVVEGGSTGQRVNALVNVGGGPTGQLMNPLPNVEGGSTRLNDNVNELNRMNYVNRMNVNDVNREQELTGARRISVVDEVVNVDRNNGYNVRYTNRVASIGYYNRGMSGLRMANVERIPEVNARSCFWNSGGGPDANAMVVAEDLWKINDEAKRTRPGTVAKERKSSKSKNRVFNDNCFKCGEKGHRAKECKKSSSQIKCINVSNLNKLSNVPIIPITVDGIAIYAMLDTGASISVMSKKLGETLKIPVEKEKIVVDTMGPGKCFVYRSKVRNKLKIGKDEEVKVKCFVSGEEFRNYDMILGTDVLSKVKLTVDMENDKVVINDEVIKLCMKNEDNELIVNSVYSLISPEDKSYKEDIVKEMPKVDQGSETTMDLQVLNVDEDLTIKDREKFELTKDLKVCTGESDEIEKPSDDEKENELPRGEVEKDDIDRNLDLNVDKALPSLKKLYFSNDSCFDKITIEEQLRDPWIREVYNEKKFENRKVEVLNGQIMIEDLTGEGYVVLIPKLHVGKVLNISHNLSGHDNSSKVYRRLKNSCYWKGMLDDIVLYVKRCKKCGRRSNKYAKDCYERSCRTSLNVRLGKQTDSLVDKDAVRWTSTKNAEKVSTKVKENMVKRRGRAYDKRKVEEYSTYDKENMVKNGGHANDKRKVDEYSMYDKGKLVDIRRPPFSKSKKVVVDLGSMLTFLKGTKGRGCLVHKSDVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCS3</accession>
    <name>A0A0N5CCS3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCS3"/>
    <dbReference type="STRING" id="174720.A0A0N5CCS3"/>
    <dbReference type="WBParaSite" id="SPAL_0001567300.1">
        <property type="protein sequence ID" value="SPAL_0001567300.1"/>
        <property type="gene ID" value="SPAL_0001567300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001567300.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21943" checksum="5554449307767D84" modified="2015-12-09" version="1">MNFSVWAFVTDGLVIIIFFVLKIITMIKSMNWLSISLSLFNIIAGITSIFLHYKSTKNNKPIFVVPSIIYQLFILIWSIVWIAVGIITISDGNLWTVENLTGPLYLIKPIDRSQTRNFYYKPGDIDANTLISIKVGIIIIAVSLIVLVLKIISIVSIKEIYNDLIYYATNKVILPSHHDMVEDDEIEMKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCW4</accession>
    <name>A0A0N5CCW4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCW4"/>
    <dbReference type="STRING" id="174720.A0A0N5CCW4"/>
    <dbReference type="WBParaSite" id="SPAL_0001571350.1">
        <property type="protein sequence ID" value="SPAL_0001571350.1"/>
        <property type="gene ID" value="SPAL_0001571350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001571350.1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10032" checksum="04B88B184099011E" modified="2015-12-09" version="1">MTNSRLPNKTTTEITFSTGTLHFKANGDAVLQKALDQMIIFSMDVFLIDILNYMMDELDFLMWKSGRDCLDTIELSNEIKKSEMNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDA8</accession>
    <name>A0A0N5CDA8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoU_methylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDA8"/>
    <dbReference type="WBParaSite" id="SPAL_0001585300.1">
        <property type="protein sequence ID" value="SPAL_0001585300.1"/>
        <property type="gene ID" value="SPAL_0001585300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056581">
        <property type="entry name" value="TPR_Edg1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24293">
        <property type="entry name" value="TPR_Edg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Edg1 TPR repeats region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001585300.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="74032" checksum="647F7EAE7CEFCC24" modified="2015-12-09" version="1">MVLQMIDALISKIEDKSVCSEDFKLLLIHFVELNIDICLDDFIRIVKQIHNFQDDQPLEEKILFIKLLEFSFNCLKESDERDLAITTFIEEMKIATNSEHIPYTLSAFYPNYQSKVSVCLNQICANDPDTNDIFDMQLLKKIGYELQFLGLISPRKVVSSLVLKIFIKQIIMSEWLDSEEDVDDSENTKYPLIILQLKRFLVESFQSKLSPPMFSRDGYNNIVNVFSKLSSCYYTGNIENERKDPLVNVNLICNTVLIPMAFTESTAQLAFTILAKLIDLSNLNLCKFKWQNLSPEVGDESKFKIEGMIALAIHHLPYFARKENSEGLFCIFSTLHKISEKLSADKFRFSKPIVNHQLVKLKSLDWIYAYVVMRFFKSLWNIEKLIIPKCFQHFMDEDSLLKYKFIRLSGNQDFLTCFTESLLEMFVLSEFCAEDFLENNNFKKIFDSGLLRTALSRGLFYPYGNHILPSMTSFKNIFSILMRKFNITPLSSIITYYIDPTDDNSVLTFYNRSIVKQLITSIFFNSCQLPKLFPENYKNIDESVEKVIRSTYLSMVNENAIHLEKRINEDFIGKIVSKDSTAKCFIIMSSEINLYVCQINSLLQLGVPESDLLFKSVTKKVVEVNDLITSIKVNNSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDL7</accession>
    <name>A0A0N5CDL7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">QM protein homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDL7"/>
    <dbReference type="STRING" id="174720.A0A0N5CDL7"/>
    <dbReference type="WBParaSite" id="SPAL_0001272100.1">
        <property type="protein sequence ID" value="SPAL_0001272100.1"/>
        <property type="gene ID" value="SPAL_0001272100"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001484600.1">
        <property type="protein sequence ID" value="SPAL_0001484600.1"/>
        <property type="gene ID" value="SPAL_0001484600"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001596100.1">
        <property type="protein sequence ID" value="SPAL_0001596100.1"/>
        <property type="gene ID" value="SPAL_0001596100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001272100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001484600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001596100.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24816" checksum="0F3CC44BF410BAB2" modified="2015-12-09" version="1">MGRRPARCYRYIKNKPYPKSRFCRGVPDPKIRIFDLGKKKAFYDEFPHCVHLISNEREHLSSEALEAARICANKYMVKNCGKDGFHMRVRKHPYHVVRINKMLSCAGADRLQTGMRGAYGKPQGLVARVGIDDILFSIRVKEANVQHAIEAFRRAKFKFPGRQYIAVSKKWGFTKFNREDFQNLCDEGRIIPDGVNVKFANDHGPLSKWIMRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CDX9</accession>
    <name>A0A0N5CDX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CDX9"/>
    <dbReference type="WBParaSite" id="SPAL_0001607000.1">
        <property type="protein sequence ID" value="SPAL_0001607000.1"/>
        <property type="gene ID" value="SPAL_0001607000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001607000.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32644" checksum="8512A78DD56560F7" modified="2015-12-09" version="1">MIYGKNSLDNIWCESTCVASCPVPTTTEVATTVTITATWIFLVFIFFSQLVILWRLKFYAVCSSCSKSTTSLSSLDREEFFCNTPGVNVGATAASCAVNRSGQIFFTIEISVPKLMQFKIEFVSGVFAGSFPESIRALWLCGSVPGGNQVCNLNGLINLQILVVSSCAIMSQAMGTISVSNELRCILTLCKSAECRCGLLIKKKFENVFSTQVIIIPSGRYNGRLATTSESYRKAMFLRRKGIVFARGSFSFEKFATCNLPNDVQEELEEVKKSRSSIFEEVKKSRSSIFEKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CEQ8</accession>
    <name>A0A0N5CEQ8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CEQ8"/>
    <dbReference type="STRING" id="174720.A0A0N5CEQ8"/>
    <dbReference type="WBParaSite" id="SPAL_0001634500.1">
        <property type="protein sequence ID" value="SPAL_0001634500.1"/>
        <property type="gene ID" value="SPAL_0001634500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001634500.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="102793" checksum="8F6EE9C80BB09F54" modified="2015-12-09" version="1">MPVNISDDNNDSCRLLVNVIRTLTTSASNDQREHEKNRLEIAYKNSGEIIDKLIKAHEPDVNACLNTFRNVSTKITGFKEGTKNVKNNLRQSTTLLECRRDDLKKLWMENEEQKYICNILKQINEIKNMEMTIEEHVKGGNFKDAVNLLKKNEILLNGQLSCIEGLSQIRHNVHDISKNLLTKIIDDLLRIIIIEPFEKHLVSLMKNVNKNVLQESELCNKLLEKYKKNVDSRDFGFTSSTENEEYMYNACAKISDSIAALAVFDQVDVALNQIYAKEAALCQKGVHDTIIVLNAITHNENRDAKLLHQLIQSLVTEFRDSYKYHSILIKELSKHAIYREHSSIILEKYWESCQRALQDVISDHLDIYPQRSNKNESLTENNKLLFRFSCGALMSSQATVEQNKLNNLVCQADPYNIINIFHLLNHFAMEIQSITKKEPCDLYTFLNSFVMDSFVERVEKDISGKLNIIFSSSDVWTSIFNVQSHEVSVLGSVVKVKSMCDHVFELIKHMETYTLRFSQQWLFILMKFIGYIEEVYNKITITNIGTDNQVRTSGKISAAWAVDEDISRLLKSLPSWVAITTQTPNETTPTSYQHNLVAESELDIKKRNQRESEILIGNLGVQKQIKRNELVTDMEHIKILILIHESLQWFTIQFRSLIGGLSKKSNEIIQYKVPDIDSNNLNIGEDTMINVLHSRINKIETISETCLLLIHLELRVHCFYYIFPLSRADSKYNEDENDQEASDFRNDLYMFHKILSQLTSKHKWKYLFEGLGHLCASIFIHSSQHMTKLRENGRKRLCRNIFAVQQLMSQITGRREMDLDRARSFYELLDHEPDRLLAMIVDKGTTFSNTEYSYLLSLAVRSHQILSSQPGALEKKMTQLREILTAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFH2</accession>
    <name>A0A0N5CFH2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLGL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFH2"/>
    <dbReference type="STRING" id="174720.A0A0N5CFH2"/>
    <dbReference type="WBParaSite" id="SPAL_0001660900.1">
        <property type="protein sequence ID" value="SPAL_0001660900.1"/>
        <property type="gene ID" value="SPAL_0001660900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="1">
        <location>
            <begin position="340"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001660900.1"/>
        </source>
    </evidence>
    <sequence length="957" mass="110311" checksum="C9F67824DF54B8A4" modified="2015-12-09" version="1">MANIFSRKKVFGKNTPPDFLARYFQITEQDSLGFNDNIVIFHPGKYGSEIVYGTSSNTLGFISCDESPPIIKFLYTIYKVFYIDNIDKKLILVITGSGKRDYKNLYILDRDILNTTKKSLEKKNSTESIVFNCNENYVLYKKEEISMISSFKLYYNINSFSFYYANANGNLNRITGEKKSLECNNDIHDPTRDSISFIFEIMNLSKYHYYCDSIQFEDLTNFTIQNFFVNVTKTPSKRDEIFIVINDNILFSTTFGSDKLNIDYWEYKYPIIGVDYDKQQEAVIVITSDGSIYLIDPTNINQINHITSKNNFFNLTTNYSELCHKNIKDFFFINTQPKNKNTNSSSNPFIIFDDTKSSKKIQEYSQCLTIFNSKNVGKKYVIASEVYDYHATSKRNFNNDEFHYTSPDDILFILCRNEFILVDLTDDPYYREVHPGLLLTLDHHPVTKTIFVDNISNDIFSRIVDLKKSHNTSIKYTRVFDFPPSLVIDKEVTGGGNNLLIIGYGNGEVYFFKLLKHTLKFIFKLDTKIIFEESNNKKVDTISELENLFLPISNYAGVFDDYLDSENLAITSLTFVKETGEMFVGNHGGYILKYTLPSKEERSVDGGNLSQISISKSNIQLPKGAISGINEELIINKEYSQLDDNYQLDISSIIKGDGSKIAVLTYERDERILAIGTEYSLHIYSFGKKKMLFEIPTFTQAEISHISNAPLSRFKSLKKSLRQTFRRKQKIDCDGNKIFESDNFHSVERQIESRGVLKATECLIGKDPYVVDIVISKESFHRDYILNVYVGLFKGEIHCFTLTDIINGTYRNTFPKDTLFYKHSAPIIDMKLFTFPGDMYPSKLLIANEERIFTRSLLCSKVRKDNYKWKITAFTGCRVKNFNIYNINTNDVVICASLSDGTICGIVLSDKKKYALRKFVDERNKNAISTAMLLSTGDIIHYNKRGCLLLKKKFLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFI1</accession>
    <name>A0A0N5CFI1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFI1"/>
    <dbReference type="STRING" id="174720.A0A0N5CFI1"/>
    <dbReference type="WBParaSite" id="SPAL_0001661800.1">
        <property type="protein sequence ID" value="SPAL_0001661800.1"/>
        <property type="gene ID" value="SPAL_0001661800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001661800.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72169" checksum="D863E35814EDE65A" modified="2015-12-09" version="1">MEIGTQMIVDDDIAMEANVVVDSALLTSDIDSAIAEDTATANETVQSPSLAVENSPENSSGNRARISKISSRKNSGKKSGNGRILFCRKCEGHNKQVTLRGHASYCPYNKCTCKTCAHVMSMRANAIIRRYRARAHETGLVLKPVQFKNGNTRLRVFPRFISDADCLPIPTERSMNDSQIRFQEAVGGSNDTQPKYVLLSDNPETRNADQINLIQTNNPQRKHVMQIVSALKKDCPKGNSRPSSKKSSTPSPKNSTASRCSSDDSFIVVEGIDMVPKGKRGNYKTRKGTPKDIKDRDGDLRDDKNDNVFDMDSSVSDDEFIDTTIPKMEDSLIKESIGHQQPPPPDPQNTVSVVEKANGPFIQENVTSQKNLATDYNKNVNLSIVSIQQSDIGNGNLSSNNDCNRYQNNGNNNQNNSSVNDYNYLLNMISNQGNNSYQCQQTSNNIDFTLQQQLLTILQNNGLIQNQTNNSYTNVQSNENTLQQNHQLPMSVFSRQVTTNNNNNNSSNTRRPSEGTENQRNVICQVSMINQQPSVQVDFPHDYDQQNQQIMPSNSLLVSALSSNNNNYQLPLNNSLLQSNNNYNTIGSVSSTEDIVRSYLLQQQVTIPPPSFKVCKTLCLTSEGQALFEQPKFRKFLCMVSELEKSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG83</accession>
    <name>A0A0N5CG83_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nop domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG83"/>
    <dbReference type="WBParaSite" id="SPAL_0001686200.1">
        <property type="protein sequence ID" value="SPAL_0001686200.1"/>
        <property type="gene ID" value="SPAL_0001686200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001686200.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40404" checksum="BBF2F1F0CE8C9898" modified="2015-12-09" version="1">MSVSDDNVSILEYDPATEGSGSTGTNRITKRKRKPKNNVDVVSVPPGEDAVALHIKLLKERENTMEGILGLLELGERVETLLKRTLWAAEADISILEMFSKMHDIHAVRQLYSEKHAAATREAVEEYGIQITPQIRDDLTKQVKASLPKSLDYGVLRTTDEVKTMLQSILNVGAISAQCCINGAGPIIFPAGVAVPNLKQLKVEYLSGAMSGRLPEHLRVVWLCGTMPLGKNIFNLAGLSELTVLVVTGCGMMANATETLTESSNLKCIITLCKAPDCKCDQLVKKKFGLAFGGQVIIVPDNRYDGKALTHTESFRKAMFQKRRGMVFHKGPATFKKFAVCRLPTQVRGEHAERKKLRMAVADHLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHG5</accession>
    <name>A0A0N5CHG5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHG5"/>
    <dbReference type="STRING" id="174720.A0A0N5CHG5"/>
    <dbReference type="WBParaSite" id="SPAL_0001728200.1">
        <property type="protein sequence ID" value="SPAL_0001728200.1"/>
        <property type="gene ID" value="SPAL_0001728200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001728200.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22452" checksum="8B354E6E1E7ED10A" modified="2015-12-09" version="1">MVLTISTIAYCKAVLHCVKYPHCPIKGFLIADGFGKNSIVIDAIPISHDIPTFAGIFESSLLFIERYCNDNGYVIAGVYFANQMLNDKKLDPCVVKLAEKLQSKYPKVYIMQLDNTKFSLESSSKCVLAHVYDTETKEWKETEQPVEDVSSTLRVASKAIDLKMERQVSDYENFLDNPKIHDILNLKLNLGLEKYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHP2</accession>
    <name>A0A0N5CHP2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHP2"/>
    <dbReference type="STRING" id="174720.A0A0N5CHP2"/>
    <dbReference type="WBParaSite" id="SPAL_0001735600.1">
        <property type="protein sequence ID" value="SPAL_0001735600.1"/>
        <property type="gene ID" value="SPAL_0001735600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001735600.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20364" checksum="F0D63BC8639A87F6" modified="2015-12-09" version="1">MASKKDNQNSLNRWKLDFTSCKSNNKYTNPPGFNPRIISSQGGETLTTDNKEQQQHLLNKRSWDIALQPIKTIPMNLFMMYMTGNAISIIPLMMVGSMFWKNIQAIITVNSTFKVLEEQMSSSIILNKIVFIIGNLLGILLAMYKCNSMGLLPNGTSDWLDFMEHPEPLQSSTWSGVILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIG1</accession>
    <name>A0A0N5CIG1_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3 copies of tim-10/tin-10, named soluble 70 kDa complex. The complex associates with the tim-22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIG1"/>
    <dbReference type="STRING" id="174720.A0A0N5CIG1"/>
    <dbReference type="WBParaSite" id="SPAL_0001595800.1">
        <property type="protein sequence ID" value="SPAL_0001595800.1"/>
        <property type="gene ID" value="SPAL_0001595800"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001729300.1">
        <property type="protein sequence ID" value="SPAL_0001729300.1"/>
        <property type="gene ID" value="SPAL_0001729300"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0001761700.1">
        <property type="protein sequence ID" value="SPAL_0001761700.1"/>
        <property type="gene ID" value="SPAL_0001761700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001595800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001729300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001761700.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9933" checksum="A0DE7877E49C99B9" modified="2015-12-09" version="1">MNSQQMQMVQELEMEMMSDLYRRMTSVCQEKCISKTYREGEITKGEAVCLDRCVAKYLDVHERLGKVLSTMSQTDEANMQKQAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIT9</accession>
    <name>A0A0N5CIT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase_H2C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIT9"/>
    <dbReference type="STRING" id="174720.A0A0N5CIT9"/>
    <dbReference type="WBParaSite" id="SPAL_0001774400.1">
        <property type="protein sequence ID" value="SPAL_0001774400.1"/>
        <property type="gene ID" value="SPAL_0001774400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001774400.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="26079" checksum="DE2A3960ECD8E3A5" modified="2015-12-09" version="1">MHSSQFYSLIDDSFGQNNSECGVAKVTMSDDTDNNLDINCLAVNDNVIGEDKFNGKSLLRVYVTNEYAREWTKKIHEQGYFAKAKTLELFTIRFVNDKTYTIYEVVCKSCDNCRRVNRNHKKNDCQKMVIIDIPREIYVLALYESLYQKDEKNKYLMLYRSLYELNNHQKLFKDIVLSYRLMRRLSNLHKKENLLKLKPGDKIIVQNIRNRTHLEVVPMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CIX9</accession>
    <name>A0A0N5CIX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CIX9"/>
    <dbReference type="WBParaSite" id="SPAL_0001778400.1">
        <property type="protein sequence ID" value="SPAL_0001778400.1"/>
        <property type="gene ID" value="SPAL_0001778400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001778400.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23053" checksum="9B4B61CCF17FCD40" modified="2015-12-09" version="1">MNSNFINLSSISSVVDSYVASKFCQKTTIYILKMLNKLCITRKLVPSFLLLDEVCSLLKFGENVDKKEFINILQNIVWTTKIKIEKNDVSALKLIASKLLKVNKHSVGESFNDEKYNIFSIKNKNFIGESDGDYITTKTSASTSAPIKNSISLSSNKPSSTISSNPIDSNLQCSTTMLPLTNSNNFDKSELKNNSADKEFFNDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B1S1</accession>
    <name>A0A0N5B1S1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B1S1"/>
    <dbReference type="WBParaSite" id="SPAL_0000002500.1">
        <property type="protein sequence ID" value="SPAL_0000002500.1"/>
        <property type="gene ID" value="SPAL_0000002500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000002500.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52781" checksum="794C54E1AB40CB1F" modified="2015-12-09" version="1">MAVQCVICLESCAASGTDHAPYSTPCGHVMGKECLEKFKKHLNNNNFNCPSCHKDTIFNNCHAIYGIAPEVKDSVTKPRNACKKLKENFFFSEDFKKNIDGTIKFFDEHNGNILIAGIAGETPSLFSNKHFIKLIVTKGRKTYNLSKSKLNIECSCLCFNKHENGVIEFCVGYINGTMKLHRYKFDGDNLKRISKNKLFCLSLLSSINRSKAIINSICFLNCNTVVFSIGKGKLRVWNKKEEWLSKTEIINECIDNESNYITQLKKTNHDDCLGIMNNRIYVFEKNGTSYELASQVDKTIISYSIDPKFYILIVLYSNESNLTQEHSTSQLFVKYKIIYDKEPQKYYTKKMRIIQNIGDEIPKSIMPSFFAIKNSKRPLVYHGIFTNIENNKLEIISLNNSRKCEGFKCVGDENLEDTPNCLGVTFVDRKKFFFKSNSIRTIAVIFKNKVVVMDISYTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B253</accession>
    <name>A0A0N5B253_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B253"/>
    <dbReference type="WBParaSite" id="SPAL_0000015600.1">
        <property type="protein sequence ID" value="SPAL_0000015600.1"/>
        <property type="gene ID" value="SPAL_0000015600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000015600.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39776" checksum="E11A33D40892D546" modified="2015-12-09" version="1">MVYIPQQPQNDSHLTQYQENPVIILPKMSNTVAGSCINSIMKVINTDNTPTDSYILMPISVIASNDPSSSFHIPRPVAKIHKSSSLSLSTLNLNPHSNSISVSPFLNDNNIKKSSSRYQLQSKRNFDKGRPFRSTIGPSKGVNIPYNHNLPPLLNSSSLSTANIRSIESNKIISIYPNTKQQNKLKFDFDNNNILQLDNNQNKRISSEDNSVIYDVPNYNVPPSLPPHSSTKISQNSTFTNIPKLKPLQTPYTTPNNINRYCSVITPIITTKYFIPPPPPPPINHSIAVKESRRQFKEILKNDRKLKRYQKKLQRGLLKRICCSSVSQLLWAILTIIGLGFIAYFILIYYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2D6</accession>
    <name>A0A0N5B2D6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2D6"/>
    <dbReference type="STRING" id="174720.A0A0N5B2D6"/>
    <dbReference type="WBParaSite" id="SPAL_0000024300.1">
        <property type="protein sequence ID" value="SPAL_0000024300.1"/>
        <property type="gene ID" value="SPAL_0000024300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893777" description="Glucosidase 2 subunit beta" evidence="9">
        <location>
            <begin position="20"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="405"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000024300.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="59083" checksum="88E64C78BC214B1B" modified="2015-12-09" version="1">MNKIVAVAILIFSVSFVSTETNRPRGVSLKDGHLYDDTNEKFQCLDGSKTIPFEAVNDDYCDCKDGSDEPGTSACPNGKFYCMNKGYTSKTIPSSMVNDNICDCCDGSDEWDSGVTCPNTCESLGAEAREKAIKKMEVIKEGWEKRKELVVEGEKMYLEQSESITSVKEEVEKLKEEKEKLENELKPFEEKEKELKDKADKIWNETVKAKKDAKAKKMFEQFDINKDGKITLDEIKKISQADSDNDKEVTDDEAKAFFGNNEEADLEKFTNDIYDIIKHDMRHKRSEDESAEKPKEQEGSEKEGNQEEQHEKEGEEAESGKDVESEGHKEDDHADQIKSEDDDEYEHKPEYDEETKAAIAEADKYREKIREISDKMHTQEDSIRNVEKFLEINFGEDKAWASLFKKCFEITQKQYVYKVCLFERTSQKDSSGYGETSLGNWENWLEQDTNPFKIQSYTNGQSCWNGPNRSTKVVIECGRETELVDATEPSKCEYVFTLKSPIACPDPSTINLHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2Q2</accession>
    <name>A0A0N5B2Q2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2Q2"/>
    <dbReference type="WBParaSite" id="SPAL_0000035600.1">
        <property type="protein sequence ID" value="SPAL_0000035600.1"/>
        <property type="gene ID" value="SPAL_0000035600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000035600.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16572" checksum="005E6C1295F1C573" modified="2015-12-09" version="1">MEPEGTTNSSQRGGQESSLNSSRNEDPSTKSNSLAVFFNSKKSSVREDSTKSPDRSTISNAEDTNSKSNLNNQESKPKLVNLYKDDPNSYSNNKAKPLNPFINSQDRDMENLLKLKDKEIRQWTIATVTLSFLSATLLGIILLMFFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3K3</accession>
    <name>A0A0N5B3K3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3K3"/>
    <dbReference type="STRING" id="174720.A0A0N5B3K3"/>
    <dbReference type="WBParaSite" id="SPAL_0000065700.1">
        <property type="protein sequence ID" value="SPAL_0000065700.1"/>
        <property type="gene ID" value="SPAL_0000065700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000065700.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13847" checksum="C6BE9494ADCCC704" modified="2015-12-09" version="1">MVKEFKNFATKNSTLSLTALINAFLYQIRFESSTPDQATPAERFFNTVFSPSLVKCNDAPGTPTRKFHVDDIVRIFFKTGKKWRKAKIIEKVGRFCYRVRLLDSSNGEKEILRHVNEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4E2</accession>
    <name>A0A0N5B4E2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4E2"/>
    <dbReference type="STRING" id="174720.A0A0N5B4E2"/>
    <dbReference type="WBParaSite" id="SPAL_0000094400.1">
        <property type="protein sequence ID" value="SPAL_0000094400.1"/>
        <property type="gene ID" value="SPAL_0000094400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="262"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="565"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000094400.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="100593" checksum="4CF3530E553D3691" modified="2015-12-09" version="1">MEFPDINDMVNKFEKVEICQKLNPSECYKDTLRGQVSAYPLQVERTAVAYRYSVAISLTKENFQKMLTSTNDLEVKMIGSKQTRRDTCMTAVDSSIKALEIPDIQYCYDGVSNLITNKEIENIDTTIPRSKFPEDCHGLIRKCSVSVEITRCTDDFVVPIGQKNILLNDALSQKQKLVYNCLEMITSQYALNNKKYFSNNNRSFHMAGREFDEDIGNGKVLKPGVCKSVRFIESNDQDRIRAAVFLDMSKNVFYKDGNLLDIIMDIVGKDEVKRLTLADYGMAFECLEGVLVTPSYRHAGDSFKLKEFSKESLKDCYFKGRDDDNVSIIEYLEKTYKIKIQHPDIPAVVVKSRGQTNYYPMCQLNICPGQTVSLQKMDSESSVCQQSNNTVKPYVRKNEITKHLMGLGLLDVNSNNVMKGFGLKLLPHAINIKLKIREPPQIFTGDGQVYPDDKGIFSDAFRQRFAEPAVIKRWVLAYNRSVSRKYADDFCRDLVQMAKQKGMTIDYPVEVAELTDDPHELKKFMKTKASEKVRFIMHLEPKVILSHDLLKYYETKYNVLTQQVTKELVENILNKRQRQSLGNVINKMNLKNGGLNIVTKNEPAAKRMCMSNNENFIIGYSLTRPKFNGDPSVVGYCGNFAPNPHNFVGDFFFQAGRTHQIDPQTLENVFVEVLKRRAANRRDCTEPPKRIIVLRDGLTDVQFKDAIHGEIGALRAACERFQSGYKPSFVMIVVNKHHNKRFFGIDSNFISTNFTPGVVIDTGCTRADYTEFYLQAHRPLLGTSKIPQYSVIVNECGATLDECQALILALSYSHQIISNSVSLPEPIYQAGELAKRGSYLFAVMKKEDVTRLTYIEDTGQINLTELNNNLCYNKTKFADNRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4K7</accession>
    <name>A0A0N5B4K7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4K7"/>
    <dbReference type="WBParaSite" id="SPAL_0000100850.1">
        <property type="protein sequence ID" value="SPAL_0000100850.1"/>
        <property type="gene ID" value="SPAL_0000100850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000100850.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11655" checksum="AAF1EF5210039EF0" modified="2015-12-09" version="1">MIFSKHIMQFIFFIFFISFIELIKSASLFKSFGGRGNGRRDSRGSSSYPLLGHSPKVGNQRHKYRHIFLGRKNGQNLNRDNIERRNILISNHRGLKYLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6A9</accession>
    <name>A0A0N5B6A9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tim44 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6A9"/>
    <dbReference type="WBParaSite" id="SPAL_0000159800.1">
        <property type="protein sequence ID" value="SPAL_0000159800.1"/>
        <property type="gene ID" value="SPAL_0000159800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000159800.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26851" checksum="954C80D8CA2FE680" modified="2015-12-09" version="1">MKYLYGMRFHNILKHTITNGQFNLKQPSFLLGTAPNRSLYYDIGKFCGKKEIAIDNKPTTEQLLAVDNFTESLIPRFFKEPLTKFLKICSDDVTFNDKMFNYNIVGKDNLSVHIAKIRFYYRYMSPYNKLEYKGSTIYENDNYVTVLWRMNTLQSTWKKYLPEFMLKNQSTGKVIEGAMEIYIDKDGQIFQLINRKLNDTDKTEAEKLDLLKKQQPMVEEYEENKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6L0</accession>
    <name>A0A0N5B6L0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">39S ribosomal protein L12, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6L0"/>
    <dbReference type="STRING" id="174720.A0A0N5B6L0"/>
    <dbReference type="WBParaSite" id="SPAL_0000169800.1">
        <property type="protein sequence ID" value="SPAL_0000169800.1"/>
        <property type="gene ID" value="SPAL_0000169800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000169800.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20022" checksum="E2BBA84E753FEE4A" modified="2015-12-09" version="1">MRRVLSSFSNVVVKNQKTCILNHRLSSSSPLAEGSPAPLPSNERVLSPKIQELVDQIANLSILEASDLNYGLRKKLNLPEVSSFPPAGMMMAAAAPASAPEESSAAPVDDIPKKMLFSVKLTKFDDSKKIALIKEIRSLMPGLNLVQAKKFIETAPVEVKNDLTQKEADDLKAALEKVGATVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6Q5</accession>
    <name>A0A0N5B6Q5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6Q5"/>
    <dbReference type="STRING" id="174720.A0A0N5B6Q5"/>
    <dbReference type="WBParaSite" id="SPAL_0000174200.1">
        <property type="protein sequence ID" value="SPAL_0000174200.1"/>
        <property type="gene ID" value="SPAL_0000174200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000174200.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31830" checksum="1EE1952E717B904A" modified="2015-12-09" version="1">MVKTKSQRMKYKFSILNDKAEEKSIKSVTEACDFVKDTLANSWGFTEFVKKDFLLDESNGLLIDDKLTILCEAEITDLKYGNHSNQKTSVNIMIPKSKILLNYGNMFESSIFTDCSINVETTEIKVHKAVLAAQSPVFYDILNSTLENSQRDVIEMTDFRVEVVKEMLRFIYTDKVSDITNMASEVLVIADKYRLDRLKAISERSLCRSLAVENVLERFALSEKFSTESLKNCCLELILENAGWITKTKEWKEFVIAHPLLVESLFIKLLNLSLTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7G8</accession>
    <name>A0A0N5B7G8_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7G8"/>
    <dbReference type="STRING" id="174720.A0A0N5B7G8"/>
    <dbReference type="WBParaSite" id="SPAL_0000199400.1">
        <property type="protein sequence ID" value="SPAL_0000199400.1"/>
        <property type="gene ID" value="SPAL_0000199400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF41">
        <property type="entry name" value="CHOLINE_ETHANOLAMINEPHOSPHOTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000199400.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48615" checksum="C912239B07B6B6F0" modified="2015-12-09" version="1">MSVKVKDLPKGKKEASLEGLNLFSKFMASFEKSLIGVWESYFQYDCVLDNDELRRLGNHKYSASDSSILDHLIFQRFWNWLVNFLPMSLAPNTITLLGLVSNLITVGILSTYCYTATEVAPRWAYFLAAIGVFLYQTLDALDGKQARRTNSSSPLGELFDHGCDSMTQVFVTLNICYAMQIGDVPSLCFIINMISVILFYAAQWATYCTGIMKFNKFDVTEAQWSVIIILLISGIFGPEVWNISLFGFKIKYFILFFSLSGCLMQFFNYMNSVFNEGNGKNGSTIAGTSIIFPLIPLLLVCIPFYFIFTGSPTTMYTDHITLLCFCFGAVGAKATNRLIIAHMSKSELKAFDLIYLAPISILLNQYYDNYFNEFTILKYATIYAYTNLLVFCISICNQFCSYLNIYCFSMGKQTDNNLRSKIGAKKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B7I2</accession>
    <name>A0A0N5B7I2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B7I2"/>
    <dbReference type="STRING" id="174720.A0A0N5B7I2"/>
    <dbReference type="WBParaSite" id="SPAL_0000200700.1">
        <property type="protein sequence ID" value="SPAL_0000200700.1"/>
        <property type="gene ID" value="SPAL_0000200700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000200700.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="24084" checksum="A714E134802B6890" modified="2015-12-09" version="1">MVPSLRFIEMDSNFDKIIDSIQIDMTFENVTKNDNRMGRIFFAFLFDTILDYRIDWNYGTFVMGEHIISVEGNVNKITCNGDLYLESINEFIDMNDKGNGIVDILNTTDITISWFKKYVRDKKYSLEGRKFYCDSSYQKNLSSTNLSFTFNIPEQIIFYKTTIFEIIKWALIQYITFAILIRSFLSQFLKFLCLNNCLDAWCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B8S5</accession>
    <name>A0A0N5B8S5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B8S5"/>
    <dbReference type="WBParaSite" id="SPAL_0000244800.1">
        <property type="protein sequence ID" value="SPAL_0000244800.1"/>
        <property type="gene ID" value="SPAL_0000244800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000244800.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40322" checksum="A349840640173D69" modified="2015-12-09" version="1">MKNSNEKNKSLLILNDNTNYKRKKPSPNTPPKKNIKSIKKKRNSNSKPNSSCKKNRLSKDSANNKNNKIKAQQAYKRVEDIRNKCNERKSIRTCLSEFTKEQVENYINNGKTEASKESFEVEEMPESYEYPEKLSDFEACEKSIRDVFKPHHGTRHLLLYAMVCLTLSFILTVILVSTSLFIHNSKNEKVISRIETVIFVAVATTLYIAEVIALVNYIIFYKRLIKKKILLIGILIHSLLLSVSTITIYTFIVFKYKDYIIVKTVFTFIINASLSVVHNAIIVSSEVKRIDEAVAFEENEVKETERKFATEKLDRILRNDLAIVMKKKINLDDKNKDKKNDQEELLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B909</accession>
    <name>A0A0N5B909_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5B909"/>
    <dbReference type="WBParaSite" id="SPAL_0000253100.1">
        <property type="protein sequence ID" value="SPAL_0000253100.1"/>
        <property type="gene ID" value="SPAL_0000253100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="426"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000253100.1"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131348" checksum="199E04A90D3F44A3" modified="2015-12-09" version="1">XGYNKNNHQSSSGTHNNKGHQSRYSSSKPANKPVTSYNNTSSGMNYKPNNNQSSGYNKNRIKTKPQKHGKVHTIEPTHDECHNDGEMNVIMHSIKEIKHMINDFKLNTLTICMLMICMLIPFGGCQPLGICRFAPSEFPRLYLQNNYDAKKAKQVTLVSVDTKCVALDVFASGYRLGNVFVDPDSNVEHYFDKKAPTFSCTGSHLVHLSGRNETFAEEVSTGTHNVDTSLKNIRAKHAMYEAGCDKLSSVSQTVPMDPHPSKIVSSTKAPVVMLTERPHIVQIVSHGTNVSASKIKAPTDVSVPSKATKSNNDAALKAASVDSLKVSSTTSGYQKIKSSLKTCEEELEKTKTLLKESTSTISDLRSEIERIKRANNMLSEQLRDSEDRHRTTLRSMTEESAKSLSEDIKTVSNALTDENRIRQECEDNWKDEIKRLNSEIEDCNTKLNKLKTANNALRGERDKASKALKSCNIDKDTCLKDLDELKSDVNRLNIALEDKDNELSEAKTLIDSHESQIQVYKNQEAALTEQLAAINNRISQLENTELENDDEQEHNSSSNVHALNECTNKEAQCHLQLIKTQSLTDLTRTELTRCESQIAVIKSRASSSPCLNNIPTTDNKSEKGLSMIEWAKKIYQLHVDEAITEMPNSIASALTLITAILVKYGFNKTAETLRKRYGSSSNNEIPYTHQLRTISEARPLTRTPIRVSRYGVIQNIRNSDSMVKLPVISINIGSNKFDALVDTGASLNVISQDAFNLIPSTHKTMVKPSLKAATVANNDKLVFSGASRIYVEANNKREQLEFHIVDKLSYDIIIGIPGLHRIFGDELTIRFNHSMPSITNVPVKTASKVRVPPRTTKVIHANTYLGHPVHAIPSHDKINCLFVNNPRWKGSDHIMTYYQTDPVIDNKFAVILQNHGSNTVLIPANTEIGNLHSIEEVDDNTIRISESHAPLTREQLMDSISWTNCTLSPKAKEVLQDIIWNNRTAFFEYDGNAGLYNGDERLNIELATSELPQRIRPGRRSREIEIDKQVENMLEKGMIEHSRSPYLSRVVLVRKKDNKWRFVVDFRAINKLIKQQSHLIPRIAGLIEEASGHNYYSVFDFKQEFHQIPLDEHSRRIAAFVKHRGIYQYKVMPMGLTGSPDKFQDIMDKVLSNIPDCYIYLDDIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B976</accession>
    <name>A0A0N5B976_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="2 7">6.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Converts acetoacetate to acetoacetyl-CoA in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16117"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="2 7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B976"/>
    <dbReference type="STRING" id="174720.A0A0N5B976"/>
    <dbReference type="WBParaSite" id="SPAL_0000259200.1">
        <property type="protein sequence ID" value="SPAL_0000259200.1"/>
        <property type="gene ID" value="SPAL_0000259200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="109"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000259200.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="76454" checksum="49504BB5964ECBB0" modified="2015-12-09" version="1">MSNCVSEYYVPPTDQGSEWNAELRFRNYIQKKYAVDFKDDYEKFWQWTVDNYGEFWMSVAEFCNVDLGKNKFSKEDIVEVDKNISEIPKWFNGAMLNYTENVLKNADDNKIAFIETFDGESFEYFTYGQLKKDIRILAEAMKGVGLKCGDAIATYMPNRYRTACIMLAGASIGCTFASCSTEFGEKAVVDRLSQVKPKLIFGQEKVVFKQKMHDNSYNFQKICGLLSDSIIKAIVMPLKNDETDCSLNGSLFVSFDEFIKSYRNVNMEEPFIYKKVPFNHPMYTMFSSGTTGLPKAMVHTVGGTLLKHVEEHVIQTDMNDKDVIMFYTTCGWMMWNWLMTALYTKATIVVFDESPIYPDKEILVKILARTKATIFGCGAKMYDTYNSMGIKFNDKYDLSNLRLALSTGSPLKPSSFEFINNSLKKKVVIGSICGGTDIIGCFMGASLNRPVVPGECQHLYLGMNCQTWNYKREPVKDQQGELVCVTPFVSQPSHFLNDEGGNKYFRSYFEKNPGVWTHGDYCEIDSKTHGIIVYGRSDATLNRFGVRIGTAEIYNVVEAYDTVIDSLVVGTRDPSDPDNEIIVLFLKLADNSKFDQVVTKLKYDLRTHMSPRHVPNVFKTINDIPYTHSGKKMELIVKQILNGEDVKNIGAVRNPECLSEYEMMFQKQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B9V3</accession>
    <name>A0A0N5B9V3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B9V3"/>
    <dbReference type="WBParaSite" id="SPAL_0000282300.1">
        <property type="protein sequence ID" value="SPAL_0000282300.1"/>
        <property type="gene ID" value="SPAL_0000282300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000282300.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14446" checksum="B94190E0320EBA79" modified="2015-12-09" version="1">MISLINSAGFIGRLQSTGAVGRLTCNGNPYNQALVKLFDEDDLDIDDLIADTKSNMSGEFTVQGSHREITSIDPKVVIFHNCNEVIGICSRKITLKIPDSYITSGSTPSKIYDIGTLELSGKFDGEERDCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAH0</accession>
    <name>A0A0N5BAH0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAH0"/>
    <dbReference type="WBParaSite" id="SPAL_0000303950.1">
        <property type="protein sequence ID" value="SPAL_0000303950.1"/>
        <property type="gene ID" value="SPAL_0000303950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000303950.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8303" checksum="5E4BD76FFB77D442" modified="2015-12-09" version="1">MDNIKFFKNKFMSYFFKDLTLSEIMDIISSYMKIKNSFDLSEIKDFLSSYGRGKDEAVYVQITKATDEAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BBQ4</accession>
    <name>A0A0N5BBQ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BBQ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000346000.1">
        <property type="protein sequence ID" value="SPAL_0000346000.1"/>
        <property type="gene ID" value="SPAL_0000346000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000346000.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22852" checksum="197CA333CCCADDA4" modified="2015-12-09" version="1">MDYVAYTITISTFVIGIIANSTAICAIVDYPEEKKNKHFGILLLVQFIAGLLTSIFQIVFPMYFLLLESHLVYILYISDSFFYNNFSLKRFFIAFAFFFLYFNVVYIAGLVFARYYLVCKQSFLNLKQGFLIFILTTTPCLCVSLFVWFFIDKDIPKNILSDWIKKNNISLIGISESTEAIAFDIVSFFSYKIHPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCC0</accession>
    <name>A0A0N5BCC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BCC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000366900.1">
        <property type="protein sequence ID" value="SPAL_0000366900.1"/>
        <property type="gene ID" value="SPAL_0000366900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="863"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000366900.1"/>
        </source>
    </evidence>
    <sequence length="1339" mass="153820" checksum="79FE57CAD07F95B4" modified="2015-12-09" version="1">MSSVCFICSEPYTTNGTGHALYSTKCGHLMGKSCLEEWIRRTRYLGRFNCPACRELLLNGDYHPIYDFSNEPLKSKFEDSKDKYLSEDNILKDCLSGKLKKGSTFFVETRNREIGRMFIEFFDVHNEYILIAGHLSYKGSSLQIYKGADIVYDTIYSYTNIITVALNKFCKNAVGFCVGFLNGNFLYVVLSITNSICGAPHENVLSIDCRRLNSVCFLDENKIVHSVGECNIFSVRTDKLSTKENWLGNVNVELKAVTNLTVKSESVLLGIMDGKIYIFEKNKIPYVVYFEENIKVTNYKYDPVVDMLSIVKSLEFQVSEDSYENNLSHVIRGMSKIPKYDNEGCRREIYMSYPVQDFTNITYHLPQHFKPTLISAKNYEKCFVYSFIPNEENGMLQMHFINDAFKVVGEKKIGNLNKCLGIFALKEPEMSSICFICSEPYTTNGTDHALYSTKCGHLMGKSCLEEWIRQTSNQGRFNCPTCRKLLLDGDYHPIYDFSNELLRSEFNDSKDKYLSEDEILKDCLSGRLKKESTFYIETGNREISRMFIEFFDVLNEYIWIVGHFSYKESFLQIHKGNDIVYDTSFPYSNISTVAFNKFREDAAEFCIGFQDGILQKGVLNITNGTYGVSNGDVLFNMGRKINSISFLEKKKFVYSVGECNIFSVPTDNFSTKENWLEKVNIELKAVTNLTVKSESVLLGIMDGKIYIFEKNKIPYVVYFEENIKVTNYKYDPVVDMLSIVKSLEFQVSEDIYENNLSHVICGLSKTFNYDNEGYRREVYMSYPIQHFPDITYYLPQQFKPVLISATNYEKYFIYSFIPSEENDMLQVHFVNGAFNVVGKRKIENLNKCLGILALKEPEMSSICFICSESYTTNGTDHALYSTKCGHLMGKSCLEEWIRQTSNQGRFNCPTCRKLLLDGDYHPIYDFSNEILKSEFGDSKDKYLCEDDIMKECLSGRVKKGSTFFLETGNKRISRMFIQFFDVHNEYILVAGHLSYEKTFLQVHKGNDIFYDKLFSYTNFITAAFNKFYEDAVKFCVGFPDGLIEHIVLPITNGVCSVPYESLLINENGQINSICFLEKKKVVYSVGECSIFSLRTDKVVVKENWLGNVNVKLKAVTNLTVKSDSVLLGIMDGKIYIFEKNKVPYIVYSEENIEVINYTFDPVVDMISIVNSLKYQGSGDIYDPDFDMILILNSLEFGCGEDIYEKNVSNTLRGISKIFMYDNKGCRRKDCLSGRLNIESILFMETGHTELKENMMMNFSDAHNRHVLVAGNDDYEDGEPPSFVRIYKGMDMVYYRNFGSSDITAVAINKFCEDKKINSICFLEDKKTALIQDNVGVHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD71</accession>
    <name>A0A0N5BD71_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD71"/>
    <dbReference type="STRING" id="174720.A0A0N5BD71"/>
    <dbReference type="WBParaSite" id="SPAL_0000396100.1">
        <property type="protein sequence ID" value="SPAL_0000396100.1"/>
        <property type="gene ID" value="SPAL_0000396100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000207">
        <property type="entry name" value="serine/threonine-protein kinase dst1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="322"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000396100.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60665" checksum="75514FFC17803F03" modified="2015-12-09" version="1">MFQKLDPELLFTRQERIGRGSFGEVYKGIDNNTGQVVAIKIIDLEKAEDEIEDIQKEIQVLSQCESEYVTKYYGSYLKGSKLWIIMEYLGGGSALDLTESGKLDENHIAIILRGILKGLEYLHSENKIHRDIKAANVLLSSNGDVKVADFGVAGQLSATIKKRITFVGTPFWMAPEVIKQASYDFKADIWSLGITAIELAQGDPPYADLHPIRVLFLIPKNDPPTLVGKEWSKSFREFVELCLNKNPDNRPTARALLRHPFIKRAKKNSYLCDVLERVQQYKASQVRAQDSDHEDDSNQVNNSDSGWEFSTVKQAPSEFVNGANYSEYNNGAQPSNSMQENVNPISNDDGTLKGGRKNYRPESPSVLSQSDVSCSGTIVVKNNGQQSEMQKVVDKLKRSSINSESSDSSRNSNDRSYINVHEPEVMPTKLVVGGNEGEASESNHYPGLRRHNQAYQKSNVSELADAPRLSLADNSLLYIIDKLSRTRHAGPSLDSLANSLKNAERMYPGISDLLVGELLKALTSPQIPKNEIDAAVRQMTNPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BD78</accession>
    <name>A0A0N5BD78_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM186 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BD78"/>
    <dbReference type="STRING" id="174720.A0A0N5BD78"/>
    <dbReference type="WBParaSite" id="SPAL_0000396800.1">
        <property type="protein sequence ID" value="SPAL_0000396800.1"/>
        <property type="gene ID" value="SPAL_0000396800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026571">
        <property type="entry name" value="Tmem186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000396800.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30894" checksum="6A9AA6D4E11A7B48" modified="2015-12-09" version="1">MLTWMAARQASLEALSRQQGVVQNNYRNNIYRGERNAAMLRKKKGAGDTVLNFRKQNSPKKQNPYEKSEILNRIGGTCIRKIHTTSKMNKKEISNLKEMVDDLNFTPVYRFNGIWVGAFLAKAKLAQTVVSLFLIPYATYKLYIGTYNFENFMIVTLIGILAPILLFAFARFYSRIIGVISMSECNEYIRVGYLSFFGTRQNRYIKVDDVVPLNETTSTKSKHMIVPLYQNSRKDYLYLATKGVEIVDEERASKLFGGLKIFNADKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDF5</accession>
    <name>A0A0N5BDF5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDF5"/>
    <dbReference type="WBParaSite" id="SPAL_0000404100.1">
        <property type="protein sequence ID" value="SPAL_0000404100.1"/>
        <property type="gene ID" value="SPAL_0000404100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000404100.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31001" checksum="45CF0DDD90F115B3" modified="2015-12-09" version="1">MSGTENFIQTVVLIISLIFQIIAISLAIYSTCSPSWQVVDIREFRAEHHHGLWLDCTRSEKPYSSMNSNIKSHNEGDSFLSHSSNIRPHRHQNDYYDSISPLHCTYKFDWAQAKIIEENIVNEDENSAAGEAEHHQFFFWHKAVLISIVSSIILGGLSIFTGMCSPCFGTCSLVFAILIFLSLVSSITADGIFFFAAHRVDNRFVQGLIGTYEQTIGHAFYIHLLSTIILLISFIISVCTSYSILRSSNTQREDIRLMDLPPINKQLIFHSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BDN8</accession>
    <name>A0A0N5BDN8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Estradiol 17-beta-dehydrogenase 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BDN8"/>
    <dbReference type="STRING" id="174720.A0A0N5BDN8"/>
    <dbReference type="WBParaSite" id="SPAL_0000412100.1">
        <property type="protein sequence ID" value="SPAL_0000412100.1"/>
        <property type="gene ID" value="SPAL_0000412100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000412100.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34804" checksum="71A1358E5073F2D0" modified="2015-12-09" version="1">MVCSNILNLFAFGGLLYLGVKVFSILKRILYPYVIASPIDLKKAAGGEWAAVTGSTDGIGKEYAIQLAKKGFNILLISRNPTKLENVRNEIQKIAENVVVETIAYDFTNGSYDDYEKVLLNELKKYEIGIFINNVGVAFEYPEIFHKTEGGLQRISDILLVNTLPVTVLTGQVIPQMLVKNKGIIVNVASFAGCHQMPELNVYSASKKYMIHLTGILQKEYSDTGLIIQCLCPLLIVTKMSKAEKTSMFSPYPDEYVKSAIKTIGNANQTTGYLPHQLQAEFSNLIPSFLMDIISKYYNAHIRTYMKKSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BE43</accession>
    <name>A0A0N5BE43_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BE43"/>
    <dbReference type="STRING" id="174720.A0A0N5BE43"/>
    <dbReference type="WBParaSite" id="SPAL_0000427000.1">
        <property type="protein sequence ID" value="SPAL_0000427000.1"/>
        <property type="gene ID" value="SPAL_0000427000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="96"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000427000.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33652" checksum="ABFF7DEBF954E170" modified="2015-12-09" version="1">MKMSEFVFVCTEALLHLQLDTEIGIKQLEIERFKITSKEKEMENYRSNDLKYAPRLLQRIKVNDKNEAFDDYVKNRDSNRFLSAITKIRAVKKVKIEYGSCDDGSNDNENVHKQWFTDMNIENIILNEIGITFSGERSYLLNVHISTILGYESLYKIENKKLIDDGLKLIFENGLCKYENVFMPMNTAGVYKRGSHWILGHLSRSKNCFFIYDSLNSTSEDVAERIVSRIRNAHHINLSHSVPRNIPQQNNGYDCGAFVCLFATNIIRGKMMEDWEITKEDVELIRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEC2</accession>
    <name>A0A0N5BEC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEC2"/>
    <dbReference type="STRING" id="174720.A0A0N5BEC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000434500.1">
        <property type="protein sequence ID" value="SPAL_0000434500.1"/>
        <property type="gene ID" value="SPAL_0000434500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 6-like beta-barrel" evidence="2">
        <location>
            <begin position="245"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000434500.1"/>
        </source>
    </evidence>
    <sequence length="1057" mass="120240" checksum="546720164D4F4A15" modified="2015-12-09" version="1">MVCFVFLVDNSASMAARTWKGTTILDEAKVWIDSFVKARLKDQVFSKVDKFLLYTSEEAVRHQKVILKDSGLLFFDQLRLIKPCGRANFPGAAEQIFNYIHLSRKLNGCDRFGYGRSPQLLHDTVIIHVTDGLSAMREALTINQTADSLQEFYDQPFRWDQKFFTVVFKISGIAPTKKQYYQISNIECDPYYESFCQSVGGRSFVVTHIGMLNTITEHIFHRAGCVGALVKFDLTGFSFSNDVERRNVNKSLKTQPVLIREHRNVKSFGGWLIPENFWPGEVKDKFPTRPVNPTLIIKSDNSFNFIDNYDFPFDKYELEPCLLSSIMLKTVLENNRNMMGNNSPVNVCWPVYVENSGPRKGIGEPIGFIKPNSNLSAVHLYLGPYNFSILDALMKEWKGKGYRLDGELNMKFDKYLREIPMYYHTILKKQMKGMKLTLRSLEDGNGLAAMSSYPPRVVNILHKIKESGRKEMEDVNKSVADSYQTCMMMSLGLNQIQSQQPIPYPISYSKHSIIPSLLDEKNAMATPIGKMIDAMNAVKDLKKLRFDFSSNPSYSPFKNSHCYKNAYALRRSAIETNNNSTLLDQTQKVMTNYELICEDKTVTPFCGGVPGEKPNLCNIEEWQSQRIQGMGDYDSYSNKRIQLGHKINMRDPFEEINGKTNKIHEFGNPFKSDKKAVIDIDEVPEEKDEIENGMNGGNVNGKRLPRQDMAKKRKGPLDLDRVFSFYRKQHNGNLGIVRGDGYISDATSDYSDTESSLSIDSPFSSRSPSPVTDKLNSILRNSSNEEHINKNKLLTKDDSKKGLVNANANEMVKNYKPAFIKTLDDYKPIKLTSTDDDYLKPLTPDDFKPPPMPHYDTSSNKMTVKDRSQIPKVQPTTPINNEPETGNSASPKYGSNTKISPLNLLSAKPLSSNIKRSATKTIYNPAAEAIEIKKKKLSTPTMLKAMGGDEKVKESTGLQPNTSVRKRQLQENEMIQLKQKVEEYVRAIDVDEALYESIISLLRETPSFPDFDILFKFSKRELTRFNKYTICSMLDENFEKIKQKKRKVDSGKVNGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BEJ2</accession>
    <name>A0A0N5BEJ2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TFIIS N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BEJ2"/>
    <dbReference type="STRING" id="174720.A0A0N5BEJ2"/>
    <dbReference type="WBParaSite" id="SPAL_0000441700.1">
        <property type="protein sequence ID" value="SPAL_0000441700.1"/>
        <property type="gene ID" value="SPAL_0000441700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000441700.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47243" checksum="19D20A3A70D8D90C" modified="2015-12-09" version="1">MDNEIQEKVRRKIHKYMEFLPDSDKTIMYLEKLSKLPVTYELLASTGVGKAVNKIVKKGTEEQSTLAKKIITEWKELVNIKQEVEDNSKKKVHEKEVKTEREEQVRKRKSFKDDDVGNSYDRPAKEIKTEEFEPTKTSFSDALKSVGTTRSRPIKRRVDSDKTTSKVISNSYDTDLIKHLVPTMRKWSPAPESKSETGKKKNEDHFEIKCVKSTIHVYAAAGKSKKVQLVNGEPPKLLTFCQDVVKKHVDMIEYVGLIPYHLLKPALERATPEQLLRIVKFNPQIESDCDELFQIICMKKPKKFINMGGETWKQTYTRTLKEEDAKFALLTSRIAKNNKASCASIRKAEVIDLKQVRSGGSFAGTRGHSSGGFSGNSRPRSGLESKYSGSSAAAATNPQKKGYLMAKTLRMFKSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BFV8</accession>
    <name>A0A0N5BFV8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histone-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5BFV8"/>
    <dbReference type="WBParaSite" id="SPAL_0000487000.1">
        <property type="protein sequence ID" value="SPAL_0000487000.1"/>
        <property type="gene ID" value="SPAL_0000487000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="521"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1253"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1665"/>
            <end position="1687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000487000.1"/>
        </source>
    </evidence>
    <sequence length="1720" mass="199448" checksum="E2008AC9D10A8825" modified="2015-12-09" version="1">MNDDPSDIDISLVGMPPPRNIEIRPKVFINNITARLIPLQNKGIQKRKLIKIKAVTGNIQKPTHKIPIIKFLTGDKYLNNDSQINNTKNISVLPVDKQSSVKLYEISQPSTTINSSSNPMIPITDSSDGLQQKNENMIKPMGKTIVVCSRKTIDATPNNIKNAGTRIVTQQQSKSLHIPRVITTTPGSSLIYKTYIKPNNSSLTIKNTSSSMTNSTTTEDDGSLLDIVNKIDSLTHSDKDEKPDNTASDTTCCQENIDDKNGEKESISEPTLENDYEFALRLQRELDAEEKRKRLRRKSEPKPEIKGNDTLVTKSKLSKKESQSTKKEKKKDDIGEEKKEDVEETSTKKRGRKTKKENNTIGKEKNDDDKTKINISPSGDNTSPKEEPKKRGRKSKKGVNNLSVTTNKTGESSIEQSSSPPASVASTEKENNVDLSLEKYPRPPTMGFEKIIKNVYRCEPDIDYRLADEVCDCRPPDPSNIQENSGCGENCISRCMNLECHGCAFGRKGCSNRRMQRRQNAPVEAFWAGIKGWGLRAKADISKGDFIMEYCGEVLNGKQENRRARRYAKDNQKHHYFMHLTSLTTIDAYYKGNISRCMNHSCDPNAQTEKWRVKGITRVGFFATKNIKKGEEICFNYHFFNYGKEPQKCYCGSYNCKGTIGEAIPNDPSAVDDDYESSSCTDTDSPSEDDSDDVDEGVDVTPSESPPDENKNVEEEEEVSKNIAKVTHKSPVKKSKKVNVKESTPPMDKPSVLIKDVSKKSPEKDSKQLEKEEDMSDSTLSSDDEVDETPLVINKKEETPIEEVELTKEEIDKIESFKEKSKAFMEVVNKEADNRTVSSSTVTKCCDMLNDCFSVQQSMAIAPIIKKITETKMKETQLLENGILKILTDHLSLKKFVDGKGCSMVNMDMLNYTEMLLDSIINILLYDKVCKYAKYIAESQLEVVLLEVYGKLVQMGKDSTISHNQEIGRLIGEIKEKVAYAKNKAKGYINEDPDAVKSTAIIEDKINRQQRREARDYYRYSHRKQRYRDSLYYRRRREYEDRRRIYESRHRYGSRRGSYDKRLSPGYNSYKKRRRRESSEDSYYNDCKRSRGDYRDDSYRDDSYTRRSYNRSPSRSYGRSRHRSRSFERDYYNDSRKYSESRRRSRSYSSDRSRHRNSGKYSDSPVYDRRDYKRKRSSSPRCASNRYNDSRSRNRSRSPRRDSPPNKYRRDDEKRKDDKKVCDYKDSAKSSSRSDRYTHNDRKRSPTPIRSYDSVKKSKIDVKEKETSGAKVKEKRSSDEKIKDNKASDEKGRDKASSSSNYKEKDKKPSDEKVKDRTPSDHKEKDKKISEEKSKDRRVSDDKYKDKKPSDEKVKDRTPSDHKEKDKKTSEEKSKDRKVSDDKYRDRKSSDEEVKDRIPSDHKEKDKKTSEEKRSDWRVSDDKYKDKRSSGDKDKYRDGRSACDRKDSDVRYKDKKDSDNKYEDKKDADDKYKDKRDSDNKYKDKRDSDDRYKDRKDSDDKYKDKRSPDDRCKNRKDSDDKYKDKRSPDDRCKNRKDSDDRYKDRRDSDSKYKDKKDSDSKYKDKKDSDGKYKDKRDYDSKYKDKKDSDDKHKDRRTSDYKTSERKSYSDKQKDRRTSDDKYGDKKISSDSLKDSSSRKERHRGSSPYVPTLKKRVDEIMGFTKDVTDEVSDKKDEDSSRKNKEKLSLSDLQHKINLAHSKIKALNESKPIHVKQIDKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGC0</accession>
    <name>A0A0N5BGC0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alba domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGC0"/>
    <dbReference type="STRING" id="174720.A0A0N5BGC0"/>
    <dbReference type="WBParaSite" id="SPAL_0000502700.1">
        <property type="protein sequence ID" value="SPAL_0000502700.1"/>
        <property type="gene ID" value="SPAL_0000502700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000502700.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14582" checksum="E532C0AFF23FE2DE" modified="2015-12-09" version="1">MDVEGFDVYRRETPKTSITDGKVIYINKKSNLMYLIDKCIKSLERTSDSVIFFALGSQINKACLVLGELQQRYSLTLDFDIFTKTEKMIDDLIPYADDEDIETRERLKSAMVFRVYRREDFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BGT8</accession>
    <name>A0A0N5BGT8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BGT8"/>
    <dbReference type="STRING" id="174720.A0A0N5BGT8"/>
    <dbReference type="WBParaSite" id="SPAL_0000518800.1">
        <property type="protein sequence ID" value="SPAL_0000518800.1"/>
        <property type="gene ID" value="SPAL_0000518800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000518800.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41674" checksum="29467BD1DCC1B160" modified="2015-12-09" version="1">MKSKKRGWISENAINKQIIHLKRIENDNPIKKQKSKGQSKDRKNFLLNIRRKFLRKPQFMKYINILLESKKDSTKLSNVSENVSDVPFSSDEDEFFTYQIDNLYLELANESMTKYQYIFNHIDNKDILLHQKQLYQDMSTFFVYIHSCHPEICIKTIFLARSLIDDVFKRKTITSENAIVIGVTCFLIASKFEDVYPITLNECIQLGNKEFSEKDICDNEVEILTLVGFRMIRSYSMEIARKLLNLQTVENAIKQICDIICICCIFDSTISSEKPSTIASCAILISHKIQNQKIDPELVRWLSYTSTTDNCALISTISQHLKTTIPNLYQKYHCFRQFINQIASEEVFELITKSINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BH70</accession>
    <name>A0A0N5BH70_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BH70"/>
    <dbReference type="WBParaSite" id="SPAL_0000531400.1">
        <property type="protein sequence ID" value="SPAL_0000531400.1"/>
        <property type="gene ID" value="SPAL_0000531400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000531400.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12677" checksum="E0B96E04B3D6355B" modified="2015-12-09" version="1">MGYCKINGSMWSSSNYNLSKRRMNCTAMEGYWDVQNLCDFCKYTGPPVGGISPTSTWKQIGAFATGVFLPIIVKKLSESALGRRILTEAAKTFPFLSSYINEPTPKSSDPLIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHF4</accession>
    <name>A0A0N5BHF4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BHF4"/>
    <dbReference type="WBParaSite" id="SPAL_0000539600.1">
        <property type="protein sequence ID" value="SPAL_0000539600.1"/>
        <property type="gene ID" value="SPAL_0000539600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11 13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733515" description="Zinc metalloproteinase" evidence="11 13">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="44"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000539600.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43651" checksum="DFDE55A3EF86703C" modified="2015-12-09" version="1">MNLFVKLFLFFLSIQKAISNNEGSLKAYGNSESYGTRIKRSIMNYMRLKWTSPIDYHINHDVDKNTVKTALKIMERETCLRFHETTNFTKGGLNYVNGSGCVSFVGKVSSSIAQDVSLGKECNLVTVALHETSHALGVIHEMTRHDRDYYINVKFGNIDPRVHFNFQTFGLTRAYHYGLKYDYGSVMHYDRLAGSANEQLAMEPKHWSYLKTIGQTTRFGFNDAKQLNIYYCNDKCKKKLKCKMGGYTDPNNCTVCKCPEFYTGKLCQKLSLSHKSCGSTKLITKTTDKELKAEGIKTCYFQITAKKGRKVQLNIEETNLVDGHVCQPNRGLEVKFLSDKAISGAMLCGRIYRKIITSEDNVVAMKYVGLTQSSRIRIKYREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BHS4</accession>
    <name>A0A0N5BHS4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="STRING" id="174720.A0A0N5BHS4"/>
    <dbReference type="WBParaSite" id="SPAL_0000550900.1">
        <property type="protein sequence ID" value="SPAL_0000550900.1"/>
        <property type="gene ID" value="SPAL_0000550900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="412"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000550900.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="96840" checksum="57D34DBA3407C16B" modified="2015-12-09" version="1">XVRLTSDQVDECVKAEFPNKEKNPRLFEIVTKTMVHSRCDISKTKVLCWDEAKNVWTKKFPEQYHKVTSITSKGKVNIKRSFDPFLDITDRFGNKVNNDFCVTYNPYLSLKYNSHINVKICESVLSPKYLFKYTHKSNGDKISADVVETVESKDEVKLHIDGRYVGPSEAVWRIMEYPILYKDWTVVRLAVHLINEDCTVADEMNNGNNNYFKVEKGYKSTLVAYYNLNKNDINARKRTIGRIFTVSPMNVELFSLRQLLLHVPGATCEGDLKIVNGVQWPSFRDAAIARGLLDTEDNYNELFEEACESAMPNMLRNYFGLMICYWPSFTRHYDIFTKFKNYLIEDYLMKYNGNEERAEAQAIFDIRNVLQSNNFNGYTDLPEVNFDVVEIDYVEDKNVLKRLGDENLKSANEEQRNFINRILNIIVNNFSEKRCFFLEGPAGTGKTFVYTTLYYLLRAEDKIVLNCASTGIVATLLRNGQTVHSMFSVPIALYDSNFRLSKLNKLRTTMLEKASLIIIDEAPMLSKYVIDYLDQQLKKVCKNDLPFGGKVIICGGDFRQTLPILPNSTRHQNVLFSIKYSPLWNVHFETVKLTRNMRVKEDEIDFPKWILDIGDDTLQKNEDGEVDIPLNIQSTGNLAILAPTNAIVETINNEVLNTLPGDVEKIFLADSIRKDSDTNENYYNMPIENLNQLTPSGLPPHVLNLKINAVIIVLRILNIKEGLCNGTRLRIIKINKRILTCIHLSGLNKDKTVLIPRIVLYSSEGEYPFRLARKQFPVRLAFAMNINKSQGQTLNKVGVDLTTPVFSHGQLYVAFSRVKSPDCLFVKTELDKAKNIVYTEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BI11</accession>
    <name>A0A0N5BI11_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5857 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BI11"/>
    <dbReference type="WBParaSite" id="SPAL_0000559600.1">
        <property type="protein sequence ID" value="SPAL_0000559600.1"/>
        <property type="gene ID" value="SPAL_0000559600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000559600.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13341" checksum="9B0D16C9D023CF1A" modified="2015-12-09" version="1">MSILCQIMSEYECPLRCSITGESTFIFNRFCSPDSKLEDISTCKTTEENGCYSMTIDYVKKSGEEGKLVKHGCYSTFTRRFGIGLPKLDKCEFYELNIFGTYYTADICRCSYDGCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIG4</accession>
    <name>A0A0N5BIG4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIG4"/>
    <dbReference type="STRING" id="174720.A0A0N5BIG4"/>
    <dbReference type="WBParaSite" id="SPAL_0000574800.1">
        <property type="protein sequence ID" value="SPAL_0000574800.1"/>
        <property type="gene ID" value="SPAL_0000574800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000574800.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="71499" checksum="DB74A15CA7B508A8" modified="2015-12-09" version="1">MPTGVMTGISDKDFCKVSHCFFALLIVFQKLISEIFGLNDMRYCLRVMSSCPRSGNKEALQEKLKSALETSTTRERVMKTILERGVKMKYCSPCVLERFLGSREVPKNDKVKNGSIAPGTNIIMKEPYFHKSVVNLSGWKIAPTSSTSGGIVFYFKLPAEIRDSILCSGNSPSPKKCLILRSTKINKENHLPCDDCYPQGMKIFIGSQEFTDLLPRKIVYSDVDEEGHLNVPVNLNEAILKLSRVNIIGECLRVAIGFDRAAEAGCTFAFAVFSSTLKTVEELVFESANKVKISVEEFSNDLDKCLSSEDCLILDSTKISLKSSLSLERIKIPFRGRNCKHISPEDLESYIRINGIVESWLCRHCKSPCTPDDIRVDEFFTKVLQKHPSVEEIELFPGGVYKIAGCETKLSINVSMVPNGEGGSDGNMVVLMSNDKENKPFLENHSSIENKGKKSNGNQLPLTSNSNNSITRCIVLDDSFDKEPPVKVPKSEECTIVSREIPTEECCAIQSGMTPRSADKINLGGAVNLEVLPSSFEPSGRSEMLALTRGTTFSRSTALNGSSPFPTQTSGSQQEAVYVIKDLVVKKSPLVMEIVNKIITNSNYYNMYTSLKPGDFKVWKPVDMSDELWEVLSMPEVQSLFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BIL1</accession>
    <name>A0A0N5BIL1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THUMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BIL1"/>
    <dbReference type="STRING" id="174720.A0A0N5BIL1"/>
    <dbReference type="WBParaSite" id="SPAL_0000579100.1">
        <property type="protein sequence ID" value="SPAL_0000579100.1"/>
        <property type="gene ID" value="SPAL_0000579100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000579100.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26122" checksum="2ED9CC24ADD85347" modified="2015-12-09" version="1">GPPTKKRKQTYNHNVGANKRVESGIFGLFFTCDGHEKQAVGEAKSLIDDAVQEMGLVNTSIEEDDKTKDEENNSKEEKEEDIVDALAKEIAAENDKSKRGNKLWSRQQPTGCKNSIFLTTPQITNSKDIYNICDKIVHKCQESLNTRYLQRIEPVEVTCEVNETTIEENIKALIDDHFREDLWVDFRPTFAINFRSRNNGKIKKNWVIEMIGSYMKENYKHLRYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BJM6</accession>
    <name>A0A0N5BJM6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BJM6"/>
    <dbReference type="STRING" id="174720.A0A0N5BJM6"/>
    <dbReference type="WBParaSite" id="SPAL_0000614900.1">
        <property type="protein sequence ID" value="SPAL_0000614900.1"/>
        <property type="gene ID" value="SPAL_0000614900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000614900.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25301" checksum="E7FFE6E8AFACB80C" modified="2015-12-09" version="1">MTNDMLRDDFVRAMESIKKNLIKYSVPNNYLYIGELTNGGSFSPKMDHLVCFLAGTLALSQKNGLSDEYLEIGKKLGETCHLFYKNPTGLGPEIAYFHEKEGKEPDIYIKPLDAHSLLRPEAVEGWFYLYRITGDKKYQDWAWEMFQAIEKYAKLETGYSSVSNVKKIPVTYKDMMESFFLSETLKYLYLILSDNQDILPLDKWVFNTEAHPLPIYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BK25</accession>
    <name>A0A0N5BK25_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BK25"/>
    <dbReference type="WBParaSite" id="SPAL_0000629000.1">
        <property type="protein sequence ID" value="SPAL_0000629000.1"/>
        <property type="gene ID" value="SPAL_0000629000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000629000.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45467" checksum="549B06DFAE0D6531" modified="2015-12-09" version="1">MFMPRIDVGYQCDEYNEEETKRIHNKYVNESFMIPLSSGGLTCNDVDIYGSSSFVIGVLPPGNNYDNVSDFKVNVVNNRTNLYFGHRLHSLNVSEVYEHYEEAELYLGYAIHYEAKCKIPSLSATLRLKINGTIQEFENKTEDNLGGMNIYTFDRRKIKDAPIGCHAVPDEIKHPALNDYYELLYSTSLLMFDEAAQKYIKVDDSQKLVSSSKYKCILNMKSNNSEIDKPNYIKETEFTINLTGEDLKKTADSKKFNKSYIWIIIGVLIFVVLLLIIGFVILKKLQLKRKKSNNDSSASLLASSSQSKAKSPTVVSKTPDASIIKKTNSDITCTNMTKTIVTKDSKTSNKVTNFEQPLVSSTLDLISKTKNPQIRIVTMNSNLDLILIFGSFLEFPSLLLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BKJ4</accession>
    <name>A0A0N5BKJ4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BKJ4"/>
    <dbReference type="STRING" id="174720.A0A0N5BKJ4"/>
    <dbReference type="WBParaSite" id="SPAL_0000645000.1">
        <property type="protein sequence ID" value="SPAL_0000645000.1"/>
        <property type="gene ID" value="SPAL_0000645000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019423">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srj"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907:SF16">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000645000.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38029" checksum="AC195A692911E58C" modified="2015-12-09" version="1">MCSVEGQILILDIHKYSTYVVEVFGLIFNFLVIYLLNTDNKSTKTSYKVCIIMHCIMDIGLGFFHLIGIFQVEAVGGTIFMTLPGVMQYINVYLAHTWCFTITNFLFTCSIFCGSITIIYRYLVVVKRKTLETKSILFMAVPIILTAAVSASQYVTSYGELPEEEYQTYKKLLNKNVWARDKVYGEDFIALTTPVTRKTEPFYNYFTIASFVIVAAIIIIFSILISIHLKGNRSNMTESTLKLEKQIQTTLFIQALLPIILGYIPNILPSFMLMFNVPFQCYIIFVGVCITYIPLINPCILLFLTPQYKKRIFNCFMKEGRFVGAKTTIFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BM60</accession>
    <name>A0A0N5BM60_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BM60"/>
    <dbReference type="WBParaSite" id="SPAL_0000700233.1">
        <property type="protein sequence ID" value="SPAL_0000700233.1"/>
        <property type="gene ID" value="SPAL_0000700233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000700233.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14211" checksum="1B6B25FE859CDBD1" modified="2015-12-09" version="1">MVFTVIPDIKRIVVNLSVLLDDEHSIDRTIHNFFSIGSENIEVDNSLHFKLNVITRNPTLSSSTSDSEMYDSLKEEFEKPLSSRFFEVYEGNVFSDSFIIDSVTTDHKRKIKRKLETKVFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BMS9</accession>
    <name>A0A0N5BMS9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BMS9"/>
    <dbReference type="STRING" id="174720.A0A0N5BMS9"/>
    <dbReference type="WBParaSite" id="SPAL_0000721400.1">
        <property type="protein sequence ID" value="SPAL_0000721400.1"/>
        <property type="gene ID" value="SPAL_0000721400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000721400.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="44411" checksum="A63A95317433FB64" modified="2015-12-09" version="1">MKCENNSKCWYNGKKYNFRYNLPSNKTIYGTRFSCNLINYLNSFGYLDEENFVDVSKTPIKGVKVVTAITQDHLSELRPLLKSFKKYFPSEIMIVYDLGLRKRAVRKLKELKFVEYRKFDFSRYPQHVSTVKSYGFKFLVVSEVLRDYPSVIWADACVRFVKSNFIERINGLVNCYKGKNETHKYKEQLIIEKEKKKMNFSSYTIKRCPNCIPKYQKVGYDKKLYKFNVEHCYKSNVLMHIPTFHGILASTHKKTLEYIPTDKSKYIPEKELQHGTGLVLFVRTKDTVENIMKWAVLCSLTKECIAPIPWFSCTGYFNDTNTFSKTHICHRFDQTLLTILLHNSNNYNNQNYITEMYDYAIFRGDKINTWKEFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BN27</accession>
    <name>A0A0N5BN27_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BN27"/>
    <dbReference type="WBParaSite" id="SPAL_0000052000.1">
        <property type="protein sequence ID" value="SPAL_0000052000.1"/>
        <property type="gene ID" value="SPAL_0000052000"/>
    </dbReference>
    <dbReference type="WBParaSite" id="SPAL_0000730700.1">
        <property type="protein sequence ID" value="SPAL_0000730700.1"/>
        <property type="gene ID" value="SPAL_0000730700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000052000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000730700.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12891" checksum="C0EE56B7A85893E8" modified="2015-12-09" version="1">MDSEWCSLNCQAFLDMNCTISQHAFSFPLGTLLQEIMRAAVYLLGLIALFCLLLAITFIAAKIKNMDLFKSNNGEDEENQYFLQNIYGGSSSRSSNSRTSIPPNIGIASIPFDRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNJ9</accession>
    <name>A0A0N5BNJ9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BNJ9"/>
    <dbReference type="STRING" id="174720.A0A0N5BNJ9"/>
    <dbReference type="WBParaSite" id="SPAL_0000747700.1">
        <property type="protein sequence ID" value="SPAL_0000747700.1"/>
        <property type="gene ID" value="SPAL_0000747700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000077">
        <property type="entry name" value="RNA-binding motif protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000747700.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="34413" checksum="F8A4DEECF78C80BE" modified="2015-12-09" version="1">MLPAIYGPLQPVSNNASSQRPSEQLITSAAAAALAQSAEHIANGSRDTTFTKIFVGGLPYHTTDKTLHEFFEVYGEIEEAVVITDRTTQKSRGYGFVTMKDRAAAERACKDPNPIIDGRKANVNLAYLGAKPRNNVQFAALSSTLSQLPLQAQLQALFPAARLGLSPLYIPTQAPAQMLAPAMSTSQFSLAAQLQAAAVANSANRHHVQTTQSTGVNQTAGVTSQNSTSLTSNSTSSLPSVNQQAYFDYAASIAAAVNNSGNVGIGIPPNTIFNPQVSSSYESYNLPPSLTTINPFYSLHLLALQKQMTITPASHESMNNQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BNN4</accession>
    <name>A0A0N5BNN4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BNN4"/>
    <dbReference type="WBParaSite" id="SPAL_0000751100.1">
        <property type="protein sequence ID" value="SPAL_0000751100.1"/>
        <property type="gene ID" value="SPAL_0000751100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000751100.1"/>
        </source>
    </evidence>
    <sequence length="1363" mass="159000" checksum="1643B800A127806E" modified="2015-12-09" version="1">MSPITRSDIFSMNFFLLTLIINFIFIIRGDDIYGKFNYPGKSCNDSIWSCIPTCRIQFEGKTGRCQKPTGEKCFGSPITYRYVNDFMSKDLIEPYGILSQYPDCWEHMKPLLCSIVYRPCSIRSFYYEGMAPSGDNLIESWQVFQQKTCFMAKERCPKLVKENLWPAFLKCDDFVRPDVHISDESLAKYERYLFVNNTLCKAKYTGLDNGTDALSNSCMWPLVKKNTSEGQSVLGPPMADSCFLPCKNSLFSSNLTYLVFQWSLRIFTGIVLVVSFSLLFYIIRYTKVYQSSYIMFLVIAFFSTNILYFFFYFISSIPYVGSKISCLDEGTIRKSHDYLMLASFDYCVFQGMLLQVCLNSSYLTIVFIIFCHYAHPKFCFNHYILLGSKSEHILGSRIPSKVLFLAINLIVSAIFCLFISLSNSISSNGIFQLCNVGSLSFKSALNMYYPIILLNIASIAIPVIIVVRRSFSMRMIKKNEEDRKHRPLFANIGAVSSWISDNIEYQQKKNCDKELGSMDTLDFNDLVFWKIDDKWMIVLIVTMILSCVFSMSLHMKLGLDEMYEEKEIERFHSCILNKHIVEGKLVQDSDFFVDSNTYSDSSDPLLRKDDILRNSSNIFTNCNLPSIDYVLPINFIIYIILLPAPFYILLISSIIGVFNERYGLKGLRERKSGCKLEREVSKSSGNSREKVTSVVEMDACEESELLSPSEQLGNLYPTKNALTQMYGNFMSYNQDIRNKVSFEKEVKANKIFSNNIVPRNECSSDAEVSTIREFEEDDMKTDNDCDLEESSNNSQYSNRTRATFATTGFDSSLTNEEKLSVIQEMYINHYNMYYQEHSSSILSSEDLDIQILPDMEVMGVDSPFNYDYNSLDRSVVFYPLYKSQVLPVDQKLLHPGYTPSQMMFILWIQYEALRPEERETFMKPDIPLFIKHNGIDVWVEPPQAYNDDRIERDEYDIFITPDNPAKNPFHYAFKCPTLLDRQKVQFNPVQLCFFIHDRPEIFSRHYPKDVSDPNNHYEMVRFYFPNNRLYVAYDDLGQLDFVLSNAKRLCESKISNESLSPFGSNYHLLLHYLESCHFLYEYCPKYYGNISEYEVDPHTRWLYFKSRLYDHIKEFFIDVEGFSIESDFDTPVDPEYKLIVKRKRWLIAVKEDPTLLFNLKIENTYQAFIYGHDVSILPDALEILISDNDPFKNDIIRRVCQKFWALENQYQFFKDSDDDPCENQFIRIFNALETYIPRAVVARNPLLRKFFNEVDQMRRTGPGGELFEDVFGIGNNYFKHEYEIPIPYDPSRYLDRRHALDYNDDMENDVNDDERMDYFFPEDEEYEEEMEEEEEFEIESESENDADDGFESGDSVDGDNNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BP11</accession>
    <name>A0A0N5BP11_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BP11"/>
    <dbReference type="STRING" id="174720.A0A0N5BP11"/>
    <dbReference type="WBParaSite" id="SPAL_0000763900.1">
        <property type="protein sequence ID" value="SPAL_0000763900.1"/>
        <property type="gene ID" value="SPAL_0000763900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000763900.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33407" checksum="4AEF3E02823F65D6" modified="2015-12-09" version="1">MSIDNLFDVKNAYFLGNYQQCIQAAEKIKCKTDTEEEEKNSYVYRSLMAQNKHSLVLSEISPNTDVVSLKCLRRLAQYYSNKNERNNIVMEIDSDVKTSDASNEQFCLLTALIYINESDFENALHLLNNCSSLEGQATMVQVLLKMDRVDLAMKKLKEMQEIDEDATITQLASAWVNTALGKEKLKDAFYTYQELIDKYGGTVSLLVSQASCLIQQEKYEEAEKLLIDAQQKDADNAEVCINLYVVNSYLGKSAESQGRLINQMKHFHPDHPWTTGYCAKEQFFEKLNTESCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BQR4</accession>
    <name>A0A0N5BQR4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BQR4"/>
    <dbReference type="STRING" id="174720.A0A0N5BQR4"/>
    <dbReference type="WBParaSite" id="SPAL_0000822600.1">
        <property type="protein sequence ID" value="SPAL_0000822600.1"/>
        <property type="gene ID" value="SPAL_0000822600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="9">
        <location>
            <begin position="211"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000822600.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62267" checksum="D11169DD6AE0B9AD" modified="2015-12-09" version="1">MEILVRHNTGLEVISNNDVLFNNQISSRELFVRCSQYSHNGKYFAFCDSSNTYILSAETKSVIASEPLQKTQSIIFSPNDNIMVTWEPYVIYGRPKPGEGPRKPNPNLRFWRCSDGQCIVVTIAEKDIIWQPQWTSDEKYALRLLGSELLVYENNSFERYMWKKSFKRISNFKISPGEAPIVALYHSEKGSDPARIEIRRIDKDFSLISTRTLFKSDKVSLKWNCKGNALLCQVFIEVDKSNKNYYGEQSLYLLTLGNDNGVRLSLDKEGPIYGAEWNPTGLEFAVCYGYMPSKLSVFNLKGDVIFAFPDGHRNEIYYNPFGSIMAACGFSNLSAGRMEFWDTKLKTLISIIERPNTTLFSWASDGQHFLTATCAPRMRMDNGYTITHYTGKNIMNKNYESPNELWDVQFRPSPLGKFKEFEIQKGSTQLSTKKREDHPLDKLVNSTSSAIKKSVYIPPHLRKPTADGKSAGRVLTKEEIAEKANKPMKSDKEKKIFNLQKKIDDTLKLKQKADSGEKLQSNQLCKIQKLDEFMAELEKLKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRR0</accession>
    <name>A0A0N5BRR0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPXV162 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRR0"/>
    <dbReference type="WBParaSite" id="SPAL_0000855500.1">
        <property type="protein sequence ID" value="SPAL_0000855500.1"/>
        <property type="gene ID" value="SPAL_0000855500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000855500.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9751" checksum="32A57D1CA732F369" modified="2015-12-09" version="1">MDSSGSPLDRLNSNITRIMERFSILIDLHRENKKIKEQICEETKKHFKIREAHENSGHNSIDFDDDNSNFTAESEELYIPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRW6</accession>
    <name>A0A0N5BRW6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRW6"/>
    <dbReference type="STRING" id="174720.A0A0N5BRW6"/>
    <dbReference type="WBParaSite" id="SPAL_0000861100.1">
        <property type="protein sequence ID" value="SPAL_0000861100.1"/>
        <property type="gene ID" value="SPAL_0000861100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF2">
        <property type="entry name" value="PROTEIN DAUGHTER OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000861100.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75739" checksum="B37CA561487B3D26" modified="2015-12-09" version="1">MENVNEEDNLELGDGSSTSTLTDSLHSRTFTNIYQLRGTDYLKQGWVAKSRGSRINLLKTKWARRYIILKQILTHKGVDHYLEIYKEEEDIYPKKVINLLHCHRIDSYIQLKKSSDIDTTIHKWIFSIHIKRKREIFFSVPSEVEMVRWVHLISNVCELLQDPNTSKKINEKKNSRKGSSKESNFEIEQKYINELENINENDFHVKDSYEPTFKKQNNGNKTNSGLPPHMQNKSSTFSPIFKKRNNSASSIHSAPFEFGHYSADNTLSKSGSMVKQPDRISLHSDRFCDKYASEFSRGFTEMVRLSQKNVNNQNNSNYNTMKSSSSTPSSHYITSPSSQRLPRKAPLTNNPSIGRSISILSNSDTSTIPRLSRNNSIIQETSSLNTNPDNDVTNWLYEYEPIDSASEDNNSGRASRVLIPVKSFLHNSRTNNGSIKSPTPSSVDFSFNTNTLDNQGTLSSTSGSIVPPVDRSKKPNRRKKSSDSSLQDYSINIDHQFTYPTKISTFPNSTTQMLNYPPNYFSVRPREIIHHGKRYKFTGSCVPPPPKTIFQISPPHSIINDAEYWNQIIAPNPLVSHVVRQTVKEQIITTGPKESPAAAIARMKKLKKEEKMREKERKRLEELSYNFEEEIPELLDYQFVDTAKTKAMGQTINEEERKRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BRX9</accession>
    <name>A0A0N5BRX9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BRX9"/>
    <dbReference type="STRING" id="174720.A0A0N5BRX9"/>
    <dbReference type="WBParaSite" id="SPAL_0000862400.1">
        <property type="protein sequence ID" value="SPAL_0000862400.1"/>
        <property type="gene ID" value="SPAL_0000862400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000862400.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="72977" checksum="0DB406661738A5DE" modified="2015-12-09" version="1">MTNLKLKDDNLMLDKTQSLKSGSPKRLTKEKNELSSKENALNNMNFVRDNFSSNVKKNFTKDRNEIRKNYEKLKTPMFDVLKNLTDTYQIFHDNDIKNDPHSVVEYLKKAKEAMNNANTKINVDKDCKNCVLVNCDERWDDERKLYYRSSKLSLLNFLNDDQLETNIPKINDKYLERKSKNTESSFSKSLKRTSSDNGKKVKQHRKKDKKVSRQTKNSKMSGNSKVQRKTKDEKKIQQKKEKPSEEKNKPEEIRNEKPSKENLGFTKIKKIDKKISNKEVPKEHLENDPSLKNKKEIKKEIKSKTSNEEIAKEHLEKESSLKNNAKIDKQKKVDNKTSTKEKPKNHLENESPLKNKEKIKKEKKTGHKTPNKERSKNHLENGSSLKDKEKIKKEKKTGHKTPNKERSKNHLENESPLKHKEKIKKEKKIKSKNSNKERTKKHLEEDSSLKNKEKIKEEKKIKSKNSNKERSNKHLEDASSLKNTVKTKKEKNTNPLSKPNYVLTEDEEPLFSEVSKTQDNTLTKTQTDTGDDKLDNKNMKMTYNTMESDSDQLAKMFSNIGGSVRLSNEMARKILRVMIEKKYVTEQEFITHFEGQLKSETKSNFTVSSFTALLKEKCRYFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSC2</accession>
    <name>A0A0N5BSC2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSC2"/>
    <dbReference type="STRING" id="174720.A0A0N5BSC2"/>
    <dbReference type="WBParaSite" id="SPAL_0000876600.1">
        <property type="protein sequence ID" value="SPAL_0000876600.1"/>
        <property type="gene ID" value="SPAL_0000876600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011945">
        <property type="entry name" value="HAD-SF_ppase_IA/epoxid_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02247">
        <property type="entry name" value="HAD-1A3-hyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000876600.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24214" checksum="97293D49454BCC4D" modified="2015-12-09" version="1">MAADGKDIKAFIYDMGGVVMKYSNCNEKLMESIQKPEAIFEDQFEALETGKLSLYEFLEKAGENNILKQKIEKLGIVDGNVEDFDSIFAKIMVRDEHIGKSIKVLKENGYKIALLTNNFYYDKMKSKSTIEKDLDDFDVVVESCRVGMRKPNADIYEYTLSLLNLQPNEAVFLDDLEANCKGAEKVGLKAIQVKTNRSEEAVKEIERLTGLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSP0</accession>
    <name>A0A0N5BSP0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein wntless homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSP0"/>
    <dbReference type="STRING" id="174720.A0A0N5BSP0"/>
    <dbReference type="WBParaSite" id="SPAL_0000888200.1">
        <property type="protein sequence ID" value="SPAL_0000888200.1"/>
        <property type="gene ID" value="SPAL_0000888200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="12">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="11">
        <location>
            <begin position="231"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000888200.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63225" checksum="E9A96FC886C4FBE4" modified="2015-12-09" version="1">MGAVIEELSNRKLFTILSILSIVQLIFFLVGAIYSPEPSTSMDFLMTPCEDSTPDEPKWIQIRPSNCKIIHELHKYSSKSPSRRDIVFQAQMPHVRNGVQLEYSPWFQFLIGILDINIEYDPNIVMDEEITMEFEVRMGYKSKNDEDWKEYYNINVTRKLHCTISEDRKVKGNFYDCDPIDLFELSSNPYPYYLLNIRLPVEDETCRKNPKAPNCGLGLIDEIKFISIHQNGGFTYIWLWLKTIITPFISYGNYWYCKRIVDLNRPKYLVEKSILALGITTLLLDFPFEWITLIIRCPLFLIFNDIRQGIFYSILFSFWLIFSGEHLVESGYGNTLKNYWKNLTLIGLASIGFLFYDAIERGIQTVNPFFTLWSSDFGTLVAKNILQMSCLSLFLYIVFLIYKVILVWNTIRRKREAQLYQSNPLRRIKVENIIFRFKFLMIFTVVCAVLTVLTYAFKQIGEIQYHDSDPTSGFLTSWTSVFFIGTFGMWNIYVILLLAMYAPSHKYFKEATILMSDIKDTMDSLSGSSEATAMATLLKPSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSP7</accession>
    <name>A0A0N5BSP7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSP7"/>
    <dbReference type="WBParaSite" id="SPAL_0000888900.1">
        <property type="protein sequence ID" value="SPAL_0000888900.1"/>
        <property type="gene ID" value="SPAL_0000888900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="194"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000888900.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40914" checksum="19FCB68F15EA341F" modified="2015-12-09" version="1">MLAEVEQKYSFEILLDNEDSNGNIKRSLYPGEEIKGSVHAKIDKPIKLEKVSLVLNGISKVGFSKKKEDYINCGNDYDTDAFQKYESSKELVKKEVIVYKGKKKELSINPGSYKWPFTFKTDKKWPASIVGLMGKIKYYIVLNADIVEEPRFSTKKKVTLSSYATHKDVIPLKKEFLTKTDFPITQYVGKPKKENKIFLEYRLTRKSYYMNDIINYKIKLTNNTPLKLGKVVVALKQDTSYDGLRQDEHSGMPEQFKHTRRVVLASVTEDLHLRQPEIIKPGTTEISFEGSLEFKDAKPDFNFQKGNIDTKTIVTVTILPSEGEQFPYPAECTIPISIKNIPDKTSNIPPLSKKKMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSU1</accession>
    <name>A0A0N5BSU1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSU1"/>
    <dbReference type="WBParaSite" id="SPAL_0000893300.1">
        <property type="protein sequence ID" value="SPAL_0000893300.1"/>
        <property type="gene ID" value="SPAL_0000893300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040090">
        <property type="entry name" value="TXNDC16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22699">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22699:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000893300.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="75584" checksum="DFEB64A9A29A6B9C" modified="2015-12-09" version="1">MKKMSNGGSGESPEGIENKPPSIMPPDHYIQTTFIYRDLTESEKKFSSNVISVINNLRQPLKEQGKVTIDNENINCNDKGFVKCEEYPKESAFHFLIVEDSSRGAAVYAIPSILNREVGQIEAALLDAFSRHSHFSLMGFASPEAKLELGFINELSVGELQEMINSNKKEEKRREKMKEILKKRKAVKVFIRGPFELDLVDEKILEFRDIKQPTSFGELEHWREDMLNNAIENNDVVFVMFWSNTSSTSTHAIKLWADASTKLKSNILLDTRKIKIGYVSCHDEMELCEIYGIGKKNQHYLFMYENGKVSLNMPNMKDGDYYVEWIQMMLDSPTIKLRDEDSMENVMNGNMVGFNGKRKAITLGVFNDKDSKEFQHFERVSLLLRGKYHFVYYIDSETDPTLSVIRPYEKEDNQLRLYEGDFSLESIMEFVSYASLPTIIDLTNGFTNDAILKRNKVIIMINNNDKKVKEEYFYKVSKYVTWETGKNTIFAYVDFKEDNDIHKVMLQKFYITGDELPYIFMYENNRFSIKKYSSNNFNVKEVVDMKDEDYDKRLLFPPHIVNPLRYLNLNKINNIFGEQNILLLAESVYEAEDEDDDIEEDPHVFEKLDLSKMGGCPMAHIALKLQEKEVESDDNEEVEEGTDYVVTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSU6</accession>
    <name>A0A0N5BSU6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSU6"/>
    <dbReference type="WBParaSite" id="SPAL_0000893800.1">
        <property type="protein sequence ID" value="SPAL_0000893800.1"/>
        <property type="gene ID" value="SPAL_0000893800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894805" evidence="2">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000893800.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17126" checksum="CC79DCDEE7D4E936" modified="2015-12-09" version="1">MRLIFIAFCTIVFFSAIYCNEGDQSQPSDFALDMMASLTKTGVTSLIKVALAAQLGPGYFLIKQALKLFKAEPQEVQDKLKEHHDRKAASAPGSVPDEPPKTLSDKAIALLEKVKGIKESDDSEEEQRKKITELVKKPENKDAFTEISNFLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BSY7</accession>
    <name>A0A0N5BSY7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BSY7"/>
    <dbReference type="WBParaSite" id="SPAL_0000897900.1">
        <property type="protein sequence ID" value="SPAL_0000897900.1"/>
        <property type="gene ID" value="SPAL_0000897900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000897900.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16491" checksum="47F5541B86B779D3" modified="2015-12-09" version="1">MKVFNALTLLIIASMPIMVENIFWYFYDFLVYGDVRNVGCNNKTEFFVQVGLQQDKMIFNATTIKCPDHEKIYKFSLPFYMYNQYKDRLYFEYRYNCTHDYGSKTSEKKGHFENIEFKWSSEHRKYMYNAGIIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTL3</accession>
    <name>A0A0N5BTL3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Origin recognition complex subunit 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTL3"/>
    <dbReference type="STRING" id="174720.A0A0N5BTL3"/>
    <dbReference type="WBParaSite" id="SPAL_0000919500.1">
        <property type="protein sequence ID" value="SPAL_0000919500.1"/>
        <property type="gene ID" value="SPAL_0000919500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="1">
        <location>
            <begin position="286"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000919500.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49192" checksum="1A5E52E45E66132F" modified="2015-12-09" version="1">MGRRNGRSRIISKDHEDVASFLLQTSQVLNHLHISGAVSPKEEDILEYIMDFNGHSEDFFDDTQYVVKDINLIMVDGSVQFLFETMFSKEIEGGKLKNISDFIDFVNSKKFVTDHTGKIIVILLRNAEYLTEFSSSFLKTFFDTPFHTRILFKFITVSKFPWHNISTRLGFNSFAMEIGLTPLDRAEMAQNLFNTLEEDHGKHFKKDELEKFVELFLGVTYTYCADYNNLLFLSRKCLDKIIDDNIQISGKSAKNLAEVNQLMSDILSYYYMGKRGNKKTKKTIYLPTIAKYAIVASYCASFNPPSSDKRFFVKQHIKQRKTMHEVKRDPKNSLHELGPKNFPLDRFKMIFSYLLSKQNAINPLYVGTLDVLGNLCNMGMLGRSMKQTNFEFPKYRSMLSKEFVEEIADSIDITLNDYLYDFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTM3</accession>
    <name>A0A0N5BTM3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTM3"/>
    <dbReference type="WBParaSite" id="SPAL_0000920350.1">
        <property type="protein sequence ID" value="SPAL_0000920350.1"/>
        <property type="gene ID" value="SPAL_0000920350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000920350.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8521" checksum="C68099E47B9768B4" modified="2015-12-09" version="1">MIYTFLFFFCSFMMKYNLYFHANLLVFSCTQFPCYCNSAVAIVNIYNLDEIDIYYHDKKLIPTSTIQPFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTP2</accession>
    <name>A0A0N5BTP2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone reductase (H(+)-translocating)</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH dehydrogenase subunit 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BTP2"/>
    <dbReference type="STRING" id="174720.A0A0N5BTP2"/>
    <dbReference type="WBParaSite" id="SPAL_0000921900.1">
        <property type="protein sequence ID" value="SPAL_0000921900.1"/>
        <property type="gene ID" value="SPAL_0000921900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000921900.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16289" checksum="23E6D2167B35D367" modified="2015-12-09" version="1">MFFRSIAALVEADLKKVVALSTLSQIGFRVLTLGLGLNYIALVHLLRHALFKSCLFIQVGYLIHCSYGQQDSRNYNGMGNVPYFIQLQLLVTLFCLCGLFFTSGRVSKDLILELFFRNTYSMLFAMIFFVSVFLTFCYSYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BTX6</accession>
    <name>A0A0N5BTX6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Merozoite surface protein 37</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000930000.1">
        <property type="protein sequence ID" value="SPAL_0000930000.1"/>
        <property type="gene ID" value="SPAL_0000930000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000930000.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31857" checksum="10B2302AE854D825" modified="2015-12-09" version="1">XTSANLALDTAKYTKEMSTNAANYVNECKNSATEAVISTVEKSVEMATIPKNMATEQMNYLLDVTTAYAESLTKKTIPKEDLGENPSIFDRLSVIVKFLASNVLDKKNLEYFQPLVQNLYGIIDKIKNNFLLLDVFIKEKKWPIGSYKDISEYLLKTKISIEEQAKKLNISPEQLLMEQIRQNTEKLDKSTEEIKLKGENLLTPQINDFLSKIITSIRNFDDSITTSKSVFDVHDEVIQKIIHLLSTALTFSGLKESDKENDDEKNDEKEVDKSDVSTNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU08</accession>
    <name>A0A0N5BU08_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-cysteine protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU08"/>
    <dbReference type="WBParaSite" id="SPAL_0000933200.1">
        <property type="protein sequence ID" value="SPAL_0000933200.1"/>
        <property type="gene ID" value="SPAL_0000933200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895163" evidence="3">
        <location>
            <begin position="25"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000933200.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="88830" checksum="2BE949E11104614C" modified="2015-12-09" version="1">MELPLWNIILIFLQLHQFFVSLYGNNDGYKCLENLGNLSRIEVGIGIYKNGSHPITNNRYYPHVENDSYKDYKYNGKTLEEVLNAKKVYIIEIDISKFDYGDFEDDKKIILMFCPTKYYQTINSSLISEYEKRSLFLRYDKPRTCSLKICEIGIYYRPYTYNTLDKILNSNEKDVFYVVINNKVREQDIKFGTYVYDNHRYPLIPCPYTNWIPNINLTKFIPSKYVMENGIQFPDEYNDRHVFVPVIPSSNDNITLYCGKIYQPNFKEINVGVKLKFGSQSTSYDKIETTRTGVKCLNEEINPINHYSFSYTPDNINYDGNSREIKKFNPEKDNIYSGQIIIVYEKATVRLTISDYTSNGELTDKFFDKQKKVEPMCNGIVSDKEATLHLKINGKIFNYNKTASGIKLVKISTELYENKILHVGCHAVVDDNSGKIYEDFYLKRYKFVLFKGKLSNFSSSNKLDKINISSTMNQKNIYGYYSCRMDKNKNSSKIKESEFVLLPEKQVIWTEPVTSISKTNNLFFCFNNYMEIGVLSVIRIELPTGSELNNLDNPSAFTANESLIIFDDYNDYGNGVMKLFCEYKAFNEPFILLKRKFKPEDVVLAESTTNGNLTRRSNSTINGNSNGTPNSTINGNSNVTPNGTINRKSNSTSNGGLSTALIVTIIAVSLIVITVIIAVAIIICLKLKNKKKKKGNDSFSSIDISNSNSESSLSSASKTTSQSVSNFLKTKNSRSKFKVPIVLGSLSDPSMSMSTSKSNALSKTPMSKVVSNERRASKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BU36</accession>
    <name>A0A0N5BU36_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BU36"/>
    <dbReference type="WBParaSite" id="SPAL_0000935900.1">
        <property type="protein sequence ID" value="SPAL_0000935900.1"/>
        <property type="gene ID" value="SPAL_0000935900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000935900.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32746" checksum="7D4FA2DE921570EA" modified="2015-12-09" version="1">MSTQDLNSSKLSKIIGIIYIVTSLLSMFCQIFIFYVFKKDKKLLENTAHKLILFLSILEFTQQIPHFSGGISSIMEKSIPTILERFFGSLLQASFMISFLTTLYLTLNRFYIFYKTIIIHFINQLLVQKIATCITVSLSLSLFITYLFHDYGLNYDYISCTWNYIMDEDEPIPIYEFEYIFVLTILSISFIFYISIFLKIIYERNRNDSTSKISFKSTDIRTLTHIITIYLFSVILEMLWWYNVDWFGNPILADSFLNYAWLLYSGMNSFINIIFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BUT9</accession>
    <name>A0A0N5BUT9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BUT9"/>
    <dbReference type="WBParaSite" id="SPAL_0000960800.1">
        <property type="protein sequence ID" value="SPAL_0000960800.1"/>
        <property type="gene ID" value="SPAL_0000960800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000960800.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12696" checksum="7B52E5025566B15F" modified="2015-12-09" version="1">MSVNLTDSTKRCAFMNGIWYPNACILKKQFMCQSHKFMDLFDPNLSKGRTLPPVAGYSTYIYDNYSQSNSQAGTLQNMMLAQITSTRSITGDTALANTQIHVLYNGTMYAATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVP9</accession>
    <name>A0A0N5BVP9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVP9"/>
    <dbReference type="STRING" id="174720.A0A0N5BVP9"/>
    <dbReference type="WBParaSite" id="SPAL_0000990500.1">
        <property type="protein sequence ID" value="SPAL_0000990500.1"/>
        <property type="gene ID" value="SPAL_0000990500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000990500.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="46851" checksum="F25CAA1A7DE428BA" modified="2015-12-09" version="1">MSSGLYAGEDVGALVFDSGSYSFRAGYAGEECPSIDIPASVGVRNKIEETPDGTREARETFIGDIDLCIPRSNTDIKGYMKDGMIEEWDLFEQVMDYIYNKCFRVEPSLHGVLFSEAPWITKDKREKLTELMFEKYNVPAFYTVKSPVLTCFAHGKASGLVVDSGASQTYASPVHDGYCLVSSTVKSNLGGDTIVDQMKKYLEKCNVDLIPSYRIASKEEYKEGEKPLYKLKKTVEVTESFEAYHKKKIVEDVVAATLQLVDNIETEDLESTVPGEYDFSTGLHKEIKRDRLTIPESLFNLKYLDVDEKIKATIMDIPSVVVTCCTMADIDLRNTLYSNVIVTGGNSLIDGFGERLNHGIAVKCPPTVKIRFNSGTTPMEKRFGAWIGGSIVASLGTFQQLWISKAEYEETGKVIVNKKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BVU6</accession>
    <name>A0A0N5BVU6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit beta</fullName>
            <ecNumber evidence="15">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BVU6"/>
    <dbReference type="STRING" id="174720.A0A0N5BVU6"/>
    <dbReference type="WBParaSite" id="SPAL_0000995200.1">
        <property type="protein sequence ID" value="SPAL_0000995200.1"/>
        <property type="gene ID" value="SPAL_0000995200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="203"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000995200.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="57161" checksum="3D839A5640FE699A" modified="2015-12-09" version="1">MASRSISRLGSVLRTSLRSPAVATSVVNACRNKTTLASRGINTTVAVSCQAQKKQSVKATAAGSKGRVVAVIGAVVDVQFDDELPPILNALEVKGRDSKLILEVSQHLGDNVVRTIAMDGTEGLVRGQEVVDTGNPITIPVGPETLGRIMNVIGEPIDERGPIPTKHFAPIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIEGGVIDLKGKNSKVSLVYGQMNEPPGARARVCLTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGGMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRGIAELAIYPAVDPLDSTSRIMDPNIVGERHYNIARGVQKILQDYKSLQDIIAILGMDELSEDDKLIVSRARKIQRFLSQPFQVAEVFTGHKGKFVSLEQTIDGFEKILKGELDHIPEVAFYMQGNIDDVYKKAEELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BW68</accession>
    <name>A0A0N5BW68_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BW68"/>
    <dbReference type="STRING" id="174720.A0A0N5BW68"/>
    <dbReference type="WBParaSite" id="SPAL_0001007100.1">
        <property type="protein sequence ID" value="SPAL_0001007100.1"/>
        <property type="gene ID" value="SPAL_0001007100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF2">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="157"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001007100.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38007" checksum="3F46335B8D5795AF" modified="2015-12-09" version="1">MSEKNKNLLDDKTIFESSVRLSINSNEILNTPKGKTSISVSKEVNSRASSYYEESESHIPISYFMSIWYKLINQDLKDEKLKAKEIIKQYTDNEITPSKYKIFLSAISLKWVLRCCWNPPSNDRSSMENNEKNYQLEEEKILILALSFSQYSDENPIHWEILSSVYKCCNLNEKHNNRKGVPRYGKHWEDIGFQSHDPPTDFRGCGIFGLCQILFLVSSGLSESIKEDIIKLSQDEIHNFPFAIVGLNFTKIIIDRLYRGKLKKLAEKEKTYISVVNGIYRGIWIMFYRIWKSRKCQINDFPNILNELKKIVKTRPKYLLNMAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BWV4</accession>
    <name>A0A0N5BWV4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BWV4"/>
    <dbReference type="WBParaSite" id="SPAL_0001029300.1">
        <property type="protein sequence ID" value="SPAL_0001029300.1"/>
        <property type="gene ID" value="SPAL_0001029300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001029300.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37700" checksum="05D8900C5ACCC39A" modified="2015-12-09" version="1">MIYQNIIFICAAIFEIPSLLLLIAIQVILILPSMKNKFNSTFYSLLFWNGIIDILSYIAFTLHHRFPNYGIFLNIYYNFYLNKTDVRVLEFLRSWSNIGQLIGTFFLSVNRFTSLKFPIKHKFIWEKFLPISLFLMFGLSIFLTWPILCDSMCYVLQNSSDINIGFRAKWLSNNAAWYNSFLVTSMLSFIFLATGLIVNMSTLLILIKMSKETNKITTQGNGKNKFNFVRERNFFLTALIGFIGQLILGIDNYVSGYFNETKQYSNFYIMVMIFPIVNDLTIFPSAWLLLYVSSPIRNILLNLFKKKKSIEIAIQYKRSTMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXA4</accession>
    <name>A0A0N5BXA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIR protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXA4"/>
    <dbReference type="WBParaSite" id="SPAL_0001043700.1">
        <property type="protein sequence ID" value="SPAL_0001043700.1"/>
        <property type="gene ID" value="SPAL_0001043700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895075" evidence="3">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001043700.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29270" checksum="905FAE1B932B8D65" modified="2015-12-09" version="1">MFRRILTILLIVSLTVPLFAVPTNKSSELLKNGVSKNNGNMTNSTDSQRQESSKHNKTNSVAEDDYIDDQTSSNKEESNGGSDDLHVGHILKNDDDDGVKVDGKKFDVFTNLLVYFEDITETLNSIGHSLADGAHVAAGKIADISQKTHNAYLVSKDQFLRTEEKVANKAHDIFLYTQGEFDYVVEEMRKEVNRHALYIGLLSGICSYFLMFPVTFLLSFIYKKCCGRRNRLSFFCRKHGSENKPLLKKERGVGAIDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BXW5</accession>
    <name>A0A0N5BXW5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-RVT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BXW5"/>
    <dbReference type="STRING" id="174720.A0A0N5BXW5"/>
    <dbReference type="WBParaSite" id="SPAL_0001062800.1">
        <property type="protein sequence ID" value="SPAL_0001062800.1"/>
        <property type="gene ID" value="SPAL_0001062800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001062800.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31396" checksum="5E6FF9278E7D7AA2" modified="2015-12-09" version="1">MANEECMRSNWSETSIYLDLIKQNKIILPTTRCLKELPDTFQRRQLLLFRMNTEISHITNQESKCPFCQEHDTREHILNGCQSETMGNLYTKRHNLVVNILVRNILNKLKISSKKQLTRGQMKQYGNITVYYDRPIATEVSSNKPDVIIITNNEGIILEVAVSGYTTMNTKRMEKIGKYTPLESDLTSSHKKQFKIYAIVIGSNGELDVDCFNEWIKVMEHYKINKKWSKNILNTIRQKVNAFSDYLFRTYLSMKQQINMETNEMAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BY80</accession>
    <name>A0A0N5BY80_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BY80"/>
    <dbReference type="WBParaSite" id="SPAL_0001074200.1">
        <property type="protein sequence ID" value="SPAL_0001074200.1"/>
        <property type="gene ID" value="SPAL_0001074200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF112">
        <property type="entry name" value="PATCHED-RELATED PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="774"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="255"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001074200.1"/>
        </source>
    </evidence>
    <sequence length="881" mass="99860" checksum="3BDC63AF3C67D792" modified="2015-12-09" version="1">MRPLVWLENTIKSGFFRLGLWIYDNHYFCFFGSILLAFILGAGAKNFREVNNVRDHFSAEDSPSRREFAIARDFFKDYGKPFTLVVALQSQDDGDILRPGYIDRAMEIENFLQYQLNVTYNGKSYAYSDFCGAQCETSDAVSIFLTMYRDSKHRKTNNVKLTYPSMDVFGHTVYLANNIFKVQTSERSKLIKSVGLISINFNAIYSNETMGKIMSLWEHAVLDFSLSSVNDPYIKVFTTSEGLVSEEIRRTGVQAAPLMSVSFLVVLIFTILCSLDRDVVKSRPWEAFFGVICPPLSLMASFGTLFWFNYEFIPIVTVVPFLIMAIGVDDVFIFLHSYRHTDENLPVREKIAHMLADAGPSITITSLTNLLSFGIGIYTPTPAIKIFCVFVTVSVIYDYIYQIFFFTAILVFGGHREERNGHGYYWFVNVKNYDKKKGAIKEKCTLERKIGKLIDNFVDYWVTFSMSTTARVIISIGLIVFWGFSIYGVLQIKVGLTSEKLFLDDSPLLPLVRIQNNIIFKEGGQMIVFVNNPGNLSNPDAIPEIMKILNKFETSLRSVGPSSSQMWLNAYLPFIGLQNRGSIDFKYKYLPEFFSLTEYHKWSHFVSIGNTSDCYIEHPNCIHKFFFSTGFANAIAWTERLELLQHWRALAEEFPQFNLTIYEDFSLYADQLLSIPPVTQQTVFYALLCMTIVLVCFTPNISTIISGVASIMSINLGVFGLLHFCSIDLDPISMATTLMAIGFSVDFIAHISFHYYKGDHEDRRERLIHALKSIAMPMVQAGSSTILSILVLALIHAYMVQVFVKVVTLVVGLGMIHGLIVLPIVYAALPFQKEISGEEKKDIKKVVPVNDNISIHSIKKVAPIEDGLNYVPTTEGYSNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYA2</accession>
    <name>A0A0N5BYA2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYA2"/>
    <dbReference type="STRING" id="174720.A0A0N5BYA2"/>
    <dbReference type="WBParaSite" id="SPAL_0001076300.1">
        <property type="protein sequence ID" value="SPAL_0001076300.1"/>
        <property type="gene ID" value="SPAL_0001076300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001076300.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17322" checksum="798CFF846724BFE8" modified="2015-12-09" version="1">MSDYTNICLSSCRKVVVERNYMYGFYRTRFTEQIPEQLNGCISYDDWTITIKSINKLFEELEKPTSKSFLLTVLTILTCTIGSIWSKIDSDRRKKKILDFIYRQNEKIFHKAGFHIDNPFECGLRMIQISVLSTGKIVDRIKSHNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BYE5</accession>
    <name>A0A0N5BYE5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin T</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BYE5"/>
    <dbReference type="STRING" id="174720.A0A0N5BYE5"/>
    <dbReference type="WBParaSite" id="SPAL_0001080400.1">
        <property type="protein sequence ID" value="SPAL_0001080400.1"/>
        <property type="gene ID" value="SPAL_0001080400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF7">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001080400.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49927" checksum="AF84C6BCB70F945B" modified="2015-12-09" version="1">MVLEVYERHFDDEEEEYEEEEEEIEEEIEEEPASEAAEAAEAAEDAAPEEEVAEEAPPPPVEEPAPKPKRPEPTEEKPAESMTEAERAILAQKKRHEEEQAAKLLDYEERRRIEKEQQEEEIRLLKEKQERRRQEREQEEREFAEMRRAAEENRRREEEERKARQEAEKARKNEEKLKRQQMMAGSFAGHSSGTNGPNFVIKKGEHDENKMGNLTGSQKKTALTKEQLEEQKAAYLAAVTRKPDISHMMPNDLKEAIKNLHARIVKLEAEKYDLEKRSERQEYDLKELNERQRQVARNKAIQRGLDPDEVSNTNLPPKVTVFSKFDRQIDRRSYGDRKNLFEKPPQKPKYKIAHGTGRPPAEWGRKTNEELEQIRKNLEPPKYVEQVKAEGDAAKPPVEPIPLVLPGLDEVEEEQEQPAAAPQEEVAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZ17</accession>
    <name>A0A0N5BZ17_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0235 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZ17"/>
    <dbReference type="STRING" id="174720.A0A0N5BZ17"/>
    <dbReference type="WBParaSite" id="SPAL_0001101300.1">
        <property type="protein sequence ID" value="SPAL_0001101300.1"/>
        <property type="gene ID" value="SPAL_0001101300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001101300.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14612" checksum="BFC43F29714AFB2C" modified="2015-12-09" version="1">MRRSFLLGMKKNIKNKPLKVKEAPTENQTGPIVKNPDGTIVIKIHATPGAKKNTILEIGDEEIRTQINSPPVDGKANDELISFFRDILDVKKSEIFIDKGLKSRNKLLVVNSPKYDVQTLKVKLYASLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BZA4</accession>
    <name>A0A0N5BZA4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BZA4"/>
    <dbReference type="STRING" id="174720.A0A0N5BZA4"/>
    <dbReference type="WBParaSite" id="SPAL_0001109700.1">
        <property type="protein sequence ID" value="SPAL_0001109700.1"/>
        <property type="gene ID" value="SPAL_0001109700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001109700.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25892" checksum="FDD92F1A1AA6F90E" modified="2015-12-09" version="1">GLLSNDKLKILCEAEIIEVKSENNDNPETSINVTIPESKLLSDYSNLFDSTLFTDCIIRVGDTEIKVHRGILATRSPIFHKIFNSTPENSQTNVVQIEDFSVGAVREMLKYIYKDEVTNIQNMADEMYKISNKYELHRLKAISEQSMCNSLSIENVCERFALSETYPNEKLKDLCQEFILKNIECIIRTNKWKKHVLVRPLLLERLLLKSLNISLTGSDSEKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C124</accession>
    <name>A0A0N5C124_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C124"/>
    <dbReference type="STRING" id="174720.A0A0N5C124"/>
    <dbReference type="WBParaSite" id="SPAL_0001170200.1">
        <property type="protein sequence ID" value="SPAL_0001170200.1"/>
        <property type="gene ID" value="SPAL_0001170200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001170200.1"/>
        </source>
    </evidence>
    <sequence length="711" mass="81619" checksum="29A73E3DB0A548F0" modified="2015-12-09" version="1">MSLSFAVVDEDHNDLVNQEEILDDDENIPKQEAFAEVVVGEDGETYIITHEDAPEIDMHCVSSIQLVTNEQQTVEHIVIIDDGTLYAGEGPFFQLQENCFEGDFIPGQTRNRTVMTREDGSLEVVYIDDSFPYGMPSSHPGSSVGEDELSSTTGKHRRNRVEGSCMCPECGQTFINTARLERHLSVHQVFGSFQCPLCQKGYKYEYNLFYHWRKTCRDIHEIMSLEERKSCDVNQLRRVVDMLANEKHKSTPQDNVLPRTVLYASSSQLNHRESGDSRLKGKIDCRSCGVLVPPNHFGRHLSLHKGDGLVDVRSPCGGFFCDLCGVIFKFHHNLIKHWRTNCPTIQQGFEHGYIDHFTMDNDNLKKMVQSLLKRVVNSQMLREMEADYATARSIQNLNDPYHQDVYFQDHLFEGRQNGRMDDDESPTHRYIDSTSGKIYFANGNVSVQCPECFRSFASQQRLDRHLQGYHRGEGTHHCVLCGHRFKYDYSLLFHYRKTCPFSNAHIDQAVREQSSAAELKKLVREVAAKMVNDTSKVSQIEIKDIVEDESKIHREMMRFPLPNESNVPPPLIMQNKDLENSKACPVCMIKFAGEKVLEMHIAQAHKGYQESDHLIEEVKSNKDIVARSDDIETKEVNFLSGPPPRSVNKFSKSKVIDMRENKKKLEERDETFVVPKDNDIEVQVEKDMLMKDDQNSFIAPPPPRRFRKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1H2</accession>
    <name>A0A0N5C1H2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1H2"/>
    <dbReference type="STRING" id="174720.A0A0N5C1H2"/>
    <dbReference type="WBParaSite" id="SPAL_0001184700.1">
        <property type="protein sequence ID" value="SPAL_0001184700.1"/>
        <property type="gene ID" value="SPAL_0001184700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005733462" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001184700.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56034" checksum="3BEE4C8CD4521937" modified="2015-12-09" version="1">MKIFINSGNISLMLLLFIISLSSSAPDSDLVTSLPGINFKPTFKHYSGFLKASDKRYFHYWYTEAQYNPQTAPFILWLTGGPGCSSIGALIEELGPFHVSNYGNTVYENPYSWNKIGNVLFLSSPAGVGYSFSTNGNITTDDDDVARDNYNALIYFLKYKFPELQGRDFFVTGESYGGVYIPTLSSLLVDDTSGLFNFKGMAIGNGMYNFPNNYNTMVSLFYYRGFMRQQLYDKVANKCCNGNPYNCDYFSLLKKPGTECRTLILYQLNSEDGLNTYNNYYQCYTDSSTGLRKKFIKRQFLRMIGVNGKEYSSIFSSTTYPLPLCAQSNNTEIYMNRKDVRSALNIPSILPYWTDCSDAVGEAYQITHYDMTPEFNKILKAKKRVLIYNGDVDSACNVIMNEQFINNLNLTVIGSDKLVTSNWYYADDIPNIAGNYIKYQEGLDFLTVHSSGHFVPTDKPREALQMLYNFIYQNDYSKPVPFSTSKQPTLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C1J5</accession>
    <name>A0A0N5C1J5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AcidPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C1J5"/>
    <dbReference type="STRING" id="174720.A0A0N5C1J5"/>
    <dbReference type="WBParaSite" id="SPAL_0001186900.1">
        <property type="protein sequence ID" value="SPAL_0001186900.1"/>
        <property type="gene ID" value="SPAL_0001186900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF201">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001186900.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31134" checksum="135D95E0ABCC236A" modified="2015-12-09" version="1">MIRIKCLINMYGISWGKILNCLISLPIVIFLNYLASNIAYSEQGFFCNDDEIYYPFREDTVSSKLISRINKIITIVVVIMGETFLYYLKKNEGNRKILIRNVVFFLLIFYIGDMALEGTGNMGKRVVSRLRPNYIAVCQPENMEKICPEGVYSQKYVSNYTCLGSSDPDEHYAFPSGHSSHSSYMAFIITFYLQYRTPYLWGVVKHFIQLLVVALSIFVPLSRVHDFKHRLSDISGGFLLGILFGYGIIYLVLGGFKKKFEKLDNNYYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C261</accession>
    <name>A0A0N5C261_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C261"/>
    <dbReference type="STRING" id="174720.A0A0N5C261"/>
    <dbReference type="WBParaSite" id="SPAL_0001207400.1">
        <property type="protein sequence ID" value="SPAL_0001207400.1"/>
        <property type="gene ID" value="SPAL_0001207400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000050">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="529"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="875"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001207400.1"/>
        </source>
    </evidence>
    <sequence length="1056" mass="121138" checksum="C9CB03A631ECBF91" modified="2015-12-09" version="1">MIFKIYLLFIYCTIISCLRILKLGFLFPLHSKTLYNISGFNLSAGAISIAIDKIKNEQILPNFNFSFEVKFDECNPTIATGLTEQLIRSNVDVIIGPTCSRSATKSSLHSTFFNKPTITWGISANSNYGNTKRLPNLITINPLISPIIIALLDVLKTFKWYDISLIATTNELGRCSNIRKAIENAIQTETGLLTIKKSFETTIPPSDEEFDHFLEDTKLNARIVVACFDSDYWRRKFFLKMFDHGMDNGEYVLINFENRNSDFMKYEFDKTMSRRLLIYEDGNIPNDGRDEDSYKIAKYTLYIDLATFPDVNFEFSKKILNSIEGWPFYCKTCNTSTALFSSIFSPYLHDGLYLWAMILNKTYNIYGEKALTDGSLYRKHCKGVYDGIVETFAYDNDCFRLADVELTGLSDRYTTTHYIRYKFSNLSSFVKTNLVNNLERTLFKEWGNKVPLNVPKCGYLNDKCPTNFIEDNKVIFIIICIVISILVVISFFLINYIIFTSKKRKADELSKWKIPLNYLQKYDEKGFMSHSLVSFESGATSRSGRINYKNNMNSTKYICAIYKDEVVFGEKHTLKVVNSKEIQKELNQILSFDNKNINKFYGMCTEIGNVISVWKYFQRGSLFDFLQTDNSIYDTFFCNTILTDLLEGLDYIHNSSIRFHGSLSSKKCLISDHWQLKLSNFDGKSIRAKNQISNIDKLWIAPETLRSEDYIGSPEGDIYSLGIIASEIFTKNLPWDYTKREEGLEELIYLIKRGGPNIIRPDINIPEGLTFNASALSLCRECWSESPKERPKLKNIAVLHKQFAQSKAKNLMDHVFATLEDYAHKLKNEVESRSKEIQEEQKKCNILLQKMLPPQISEKLKLGIHVPPENYDNVTVFFSDIVKFTTFSQKCSPFQVVNILNELFSQFDNIIEGLDVYKVETTGDGYLCVSGLPHRNDDNHVVEIAKLALGFMKTCQEFKIFHLPNEKIMLRIGCNTGPCTAGVVGLSMPRYCLFGDTVNTASRMESNGKPGRIHTTESFYSIISTFGNFIMEHRGEVIIKGKGVMNTYWLNGMKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2N2</accession>
    <name>A0A0N5C2N2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2N2"/>
    <dbReference type="WBParaSite" id="SPAL_0001224200.1">
        <property type="protein sequence ID" value="SPAL_0001224200.1"/>
        <property type="gene ID" value="SPAL_0001224200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001224200.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8690" checksum="ABCC1A7F4A255A6A" modified="2015-12-09" version="1">MSYTYRTIIIPQGLYISAFGNVTWIDEGINSVKAALNNTKHPEKSYVKNVTKNQEFFLYLYAGGSNYDDIVITEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C2Y5</accession>
    <name>A0A0N5C2Y5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-related protein Rab-1A</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C2Y5"/>
    <dbReference type="STRING" id="174720.A0A0N5C2Y5"/>
    <dbReference type="WBParaSite" id="SPAL_0001234100.1">
        <property type="protein sequence ID" value="SPAL_0001234100.1"/>
        <property type="gene ID" value="SPAL_0001234100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001234100.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22916" checksum="E8F9ECAB20EA248D" modified="2015-12-09" version="1">MAVNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDTTDQESFNNVKQWLQEIDRYACENVNKLLVGNKCDLTEKRAVEESTAREYAEQLGIPFLETSAKDSKNVEQAFLTMASEIKNRMGPLQQSGANPSSVRIGPSQPVADKKSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C364</accession>
    <name>A0A0N5C364_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="12">SRP68</shortName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C364"/>
    <dbReference type="STRING" id="174720.A0A0N5C364"/>
    <dbReference type="WBParaSite" id="SPAL_0001241900.2">
        <property type="protein sequence ID" value="SPAL_0001241900.2"/>
        <property type="gene ID" value="SPAL_0001241900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0733">Signal recognition particle</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="444"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001241900.2"/>
        </source>
    </evidence>
    <sequence length="579" mass="67701" checksum="941A14CC3E3E04A0" modified="2015-12-09" version="1">MAVSEEVPMEVEKNDTLPLFETFSILKSIKEAQQKHGLRHGDYNRYRKYCGDRILRIRKRLNFTHNYKSVKKIRSKWQEKSVTKDLVTELGFVEIVMFDAERDWAYAQHLKHEIGNDTHSRKKFHMRRKLRNAVYHSSHLEKLIKNNDRFDAVSKLEVQSYNSYIKGVLNVELKQWKVAAECFRTVKTIYEKLAGVVKFPDMIQLYNSRCREIQPLLRICEYNLGGTSDAVSDMIRLKHDGSSEMSAEFEKLIDELQVKSIGDMESSVTWATFTTPVSQLKVRQLILQEKGLQNELDSYKSFDEKISVYEKFLQNLREELGKLIDERKKLPPSSAEDLRNPLVITIHYLEFLKFKISSERYLLMINNMKYGNIAKNVKPQDFLRLYGSIIQNSHDILAISGAIEDKKLVSAFTFKAQYYQAFKTFYMSQVYNQINKPSESEALLARSEERVKNLLKVFDGLKENHYVTEKRKDLDELKTLIEEAKVTNKANLLSYTLQNSEENSYKLPSGYVNENPDKLYMFEPSDIEESEKTENGLPIFNLGVELQPMPAKPMFFDLALNHIKVDDRLKKKYPDIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C485</accession>
    <name>A0A0N5C485_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C485"/>
    <dbReference type="WBParaSite" id="SPAL_0001276700.1">
        <property type="protein sequence ID" value="SPAL_0001276700.1"/>
        <property type="gene ID" value="SPAL_0001276700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001276700.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13939" checksum="3045EC4FE025286E" modified="2015-12-09" version="1">MTATLNTKEIKTTSSNLKIESKIKKVKKIKKLHFTNMKNFKLKKVAGLSNEEIHEMEKLRNMLPPGMNTQDPAELLLNVASYIGKLTTKVVEKVHNGSLPKSVLQPITNKKMKKFSKGSIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4A2</accession>
    <name>A0A0N5C4A2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GLTSCR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5C4A2"/>
    <dbReference type="WBParaSite" id="SPAL_0001278300.2">
        <property type="protein sequence ID" value="SPAL_0001278300.2"/>
        <property type="gene ID" value="SPAL_0001278300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2043"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="759"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2077"/>
            <end position="2099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001278300.2"/>
        </source>
    </evidence>
    <sequence length="2099" mass="242298" checksum="581890121855C175" modified="2015-12-09" version="1">MNQNTNPPSTKMKVLSKAALKYYPEDLIKKVEKEEQQQFHIESLQSIHDTSIRGPPSRKGRKRIPDNNSTTNTQQNNDSSTGRASNNTNQKLLTPNNSTNKSKSTPRTRKREGGVGLSATEQNVLKILAANAHELGNQKVPPITIQRSQSNVSTARIVQEKQHNQQPPPQPPPPTNNVKGITNEHPKNNISPQKTIIPRTAGHHQTISAVSKASFELTPNITPNIRSNITKRDVDLVPQLAPQRNKSLNRISVSKIEPEIVRTVPKLANHNSQTTPIVSTHLVISPPPKRTTSTPMQRIQPVRPIISPEQQTPLKVTTTHQQQEIVNNASISPNQVQLVNKQSTLHTTQSNTTGHSTPTVNVQVSSQQQMLIEQQMLQQQNQHIKQYSQNQAVKEQLIEQQPHIRVQKSNQAQNIQQQIQISQQIQQKHIQQRQIQQQENHQQQQLQQIQQQQQLLQLQQQSQNQLLASKIQLQETIQKLQEQQKLQEKLILEQKIIEQGTVEKLLVEEDNRLSEQQKFILDQNKVIEQQSDIPTTILYTPQQGSIQTIGNVSANISHQNIPNIQNQQTLQDIINQLSMQNAANQQNQKRLLEQQRFQQETEMVREHMGRMIVANNLNQPQPWQNRSPVSNQDLLNYLVNQFASINPQILNQFPIGHDALQQLSHGKSDQAFQRMLIQHLVNQLHLLLNQTVSPNNPIITQRQTQSNQQNQNIQDNTNVNMSNTNSEHHQQQIAFNTALNNLAAAGITDENRIRLQQEYAAVIRSFQEEESKKQKAEEDRKKLEEMIKKQQGEEELKKMEAEKQRLQAEDLMKHQEVEKRQIELERIKKIEAENKRTIEEERKRMEEKKRLKEEKKKHLKERMEEECNVNVQQEVKKLVEIRKTKQDDSRKFHKIQEIHITRLPQIVDKTRNILIENKKASNVEERQKRVVEEMHNKIKQEVRQQQQQSVPKLKIVEKVIKEQTKEHIKEKVVESNEEQLQEEQNRREVIALHKERVLEKEKIGAFILQANQIYQLNKNCNMDEFLKLCICLDPLTIIEEKVCGKNSLFKREDLLKIPPKVFLEDLSAEHRRVCIELEEEAKRLNINGKRLPFVETIPIKNSENTLKRVAVSTSSTINIPAKRPCLEKSINTPVIQKTTIVSRQKSTQCPSSFLPPSSLKSPTTTTHSTVIKPVVRTSINGRELIPPKMILIQKTTPGQLQSKQDNATVIFPKIEKRIPVQSTAPVVLPTKVIKPILVNNKNEIKKIASPVVLKRSAVVKLKNDDKNLQGTQGTLGKTCKSRKFCIPVLVPKSVVSMTRSQIEEQLRAFKAASNVSSSSSTNAQSNTSNEVGPDSSKPGPSGVKIRLSNKDIEILRNKGKSRSKKSTLDIVNNIKDKFEKDILNEFNVELTKMENIVDGKESNIIFENGTIETNNLNFRNGFSKKKKNKDGEKMMKKMRKKVKGRERKIKFKDNVGVHYFTPVGSEDEYIEPPIPVLEQISFVEDLIKKVIFTQNTSQKQKNEALVRLNSKLEDKQNVFSNGVDENDILKSDFISQLISFIIQFKKKLTILDNLTEEVNEETGKLDVYSDAEKLKYRFKVQIKNELLKLDEERKKNTYDRLKSKKIDRLTGSNCGKDDQTIVSARKDVILDIPDDVDLRKEDLQCHELIDGRDVSMEDDETVVNEEKNLQWDKIKLPKDILKDNLKYLTKKQASYIYNFSKSIPTSVKKIVIDSSPSVYDAMKMDYIVKNPSLKNSSNMKIPKSIDILLKTIKRNELGIPIFKSRRDLFICKVFLKRFILSKLYSIAKKRTKLLEGIHSRIDEIRKRQEYERELQIRKHNREKREIKIDVDYMRKFMTDKIMSEYETEKKESMKRMLEKLDCEEQYQYNELKEWSLNRDLNSKYAPPRHTSYLRRNLVDSKNIIETTRRGAKKKVVVEDPIPHYMLPCSSVRIDKDIELLEKEWKEKQASLKIDEEPVIAKPNARGKKPNTITVIYEENRVIRDGKMFYIHQNVFCEFRHIGQMMCYMFLINKDECFLRSRLLGDTRIFCVSKKDLETGRVVFKRKASQKKTPKDPNEPSPPKARAKRGGRTSRGGRGARGRRGATRARGGRGNRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C4E7</accession>
    <name>A0A0N5C4E7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C4E7"/>
    <dbReference type="STRING" id="174720.A0A0N5C4E7"/>
    <dbReference type="WBParaSite" id="SPAL_0001282800.1">
        <property type="protein sequence ID" value="SPAL_0001282800.1"/>
        <property type="gene ID" value="SPAL_0001282800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF56">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001282800.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="104556" checksum="6CD01980A2001454" modified="2015-12-09" version="1">MSSTFRSEPMKLYQLIIQKDNAFNVLAELGQHEFIHINEHKSPSNVFQRAYIREVQRCISMERSLKNLANQIWDSKIPEGKNVLRFDHYLDNITEVGKPKDLITISYEIEEREKVVIELTKYEENLKNQLDEMKEFEQVLDKVNEFFIDHVDDEAIHTLESAVSNERISLAHDIELERETSNLSNDISIPWFVAGVIDAQKRFAFERVLWRACRRTAFVRTSLIEIEECTFLQKKPERCVFIIFFKGKKLQDIVDRVCDGFGAKQYPCPKTARDRHRSELEVKIRMDDLVTVINSTISQKGDVLTSTAKQINEWWKEVHLQKTIYHYLNSFKFDTSGNFYVAEAWIPDVYIDDVRDALQECVNKRGTVLPILNVIDSTEIPPTLTMSNKFTNCFQGIVDSYGIPTYGEINPSIFTIITFPFLFAVMFGDAGHGVILALFGFFLIYKEKIIEKVQELDEISSIFFGGRYIIFLMGLMSVYTGIIYNDAFAKSFNIFGSSWQIPYTENNLTSWILESSNRPFDLTLDPLYAFNNTQGPYIIGVDPIWNLSKNKLNFLNSMKMKASILIGVSQMTFGVFISFFNYWYKKSFIDILTNFIPQLLFLTSIFVYLCIQIIVKWIYYSVHPGEVFGLYYPGSHCAPSLLIGLINMVMLKKRNVGFINGSSTEYIEMKGCYLNQWYPNQSDFERTLLLIALMCIPIMLFGKPFYELFKNRKKSKYYYDVKNINETLELIAINQPNEDNTITSTTSHIRKHPSSNTLNPSVSDKKTSLSAEPGESFTNLMVHQSIHSIEFVLGCISHTASYLRLWALSLAHAQLSEILWDKILVEGMQMLPFYGPISVFISFFIFFILTVSILVLMEGLSAFLHALRLHWVEFQSKFYEGNGYGFNPFSLKAALKILQPAYARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C534</accession>
    <name>A0A0N5C534_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70244"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C534"/>
    <dbReference type="STRING" id="174720.A0A0N5C534"/>
    <dbReference type="WBParaSite" id="SPAL_0001306300.1">
        <property type="protein sequence ID" value="SPAL_0001306300.1"/>
        <property type="gene ID" value="SPAL_0001306300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000041">
        <property type="entry name" value="UDP-glucose ceramide glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001306300.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45305" checksum="25BDA8AC77AD8FE4" modified="2015-12-09" version="1">MIPVITHQGSVSNIYTNLFDFFFIASALFVGGLWILHILSYKYGNYRLHKNTEYMKSFPGVSIIKPLVGKDSNLRTNLETFFLLNYPTYELLFCLNSKDDEAYSIVKDLCSTYPNIETKIFFGGENVGLNPKINNMMPAYRYSNYSLVLISDAGIYMKKNALTDMVSCMKSNIALVTQQPYCKDRSGFAAAFEKVYFGTGHARIYLAGNCLQFTCSTGMSSLMRKNVLDECGGIQAFSQYLAEDYFFGTAFAKKGWKSCISHMPALQNSSPEGIQSFNARICRWIKLRVAMLPHTIILEPLQECFASGILGAIAYNKLFAINPIFFFLCHAVYWCFWDYHLLCTVENGPPNFSISQFVILWLLRESLAFPLFLKALIDPKIIWKAGIFKLSWGGKIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C5L9</accession>
    <name>A0A0N5C5L9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C5L9"/>
    <dbReference type="STRING" id="174720.A0A0N5C5L9"/>
    <dbReference type="WBParaSite" id="SPAL_0001324600.1">
        <property type="protein sequence ID" value="SPAL_0001324600.1"/>
        <property type="gene ID" value="SPAL_0001324600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060169">
        <property type="term" value="P:negative regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000057">
        <property type="entry name" value="Adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF43">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001324600.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46727" checksum="74934266C132DD9F" modified="2015-12-09" version="1">MIEWRVCEIYKFIFHLIVKIFTFLMLHYQNTTENKMSFYPPEVTEETKKTFNFPLVELHVHFDGSIRIETIWDLIQKKHIEIEGVHNIVDLRDILTTHKPDDLAGVLRAFDVFLPIVRGDLEAIERIAYEMVEDQAKNNVCYFEARYSPQFFSDKTEYDLPLPSNYGPRKEITCEQIVEAANRGFKRAEADFGVVVRSILCCIRGFEKWAEEVLELVIKYQNDGVVAMDVAGSSGGADEKYSHQVTEVFQKAHELGIPTTAHAGESGTYKEVKNVVENLKVQRVGHGYHILDDEDTYKKIALHDRIHLEACPYSSIMTGSCDKVWQNHPTKRWSEDDANFSLSTDDPTCFGNSMQSDLLIAKDYIGLSIHQVWKCQLNAIESCFLSEEDRNIREKLIAMIKEAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C658</accession>
    <name>A0A0N5C658_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5C658"/>
    <dbReference type="WBParaSite" id="SPAL_0001343300.1">
        <property type="protein sequence ID" value="SPAL_0001343300.1"/>
        <property type="gene ID" value="SPAL_0001343300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF94">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="259"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001343300.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="101212" checksum="549881318311CC74" modified="2015-12-09" version="1">MILLYKHLALYIAKNPYFIIFITLITTLPICSYYIFLPFSFKTDIRRGFAHKNGEAKYEFQVLGDFYNLSVDNIEIIALIIKGKNQTRLPITFEVLSEIERLDHFIQSKASSNNNETIKLKDIYSSRGTFNFLFDAFKMGYDLQKFNYDVSSVLSDNINLSYPNSYIFGHKVFLGSHFFGVKFHNDTSIPHISMIKDVDICSLWYMLNPNTNNQYIIMKDIEKNLFEYFKYDNFSKILNIQIYGDEIANMEMLRGSINTSKMLIFGITGMIAYMFFVFRDIKFLSQIILLIGALASPGFATLIAYSLMGWFGVSINSMMSITPFLVLGIGVDDAFLIYHCWQKHSKIDNCIKRFTTVIQEAGPSMMITSVTNTLAFGIGITSPASQMSDFCICTAVAVFADFILEFSIFAPLLLILNTDKINDTHKEIRQDDIFMEKNGYYWSPYTKFIISKKGKIIVLFITIIMYTLVGVGIKGMESTFQPKKTFPQDSELINVFKNLDQIYTEYAPVTLMINSPPNITNSESNRKFMEMVEKLEEFPESWSKERSYVWLRDYEEYFNKNTKNSSKPLSYELVPKFLNDNYLNDKSVVKYRFDKNGEVKLDAFVIVIINHQKRTWHERGYLLSRVRNLIKKYPEFNVTAYDYDATIFDLIITVPEELLKAVLLTIGCMSIVCFLVVPDIVITSIAIISVTSIALTLIGFLGLLGQDLDIVIMVNILMAIGFSVDYAAHISFHYYKLKVRLRNEINYAKINNEHQFIILSKTFSYVGVPMIEAALSTIICMLPLFLIHVPIVKTFAQTVCLVSTIGTIHGLLITPCFLTTNIFNNYDKKREHYMTVLSNLKLTITDDGKTSSTYIDSKTVNTVFENDNDKEMATSISSGHIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6R2</accession>
    <name>A0A0N5C6R2_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5C6R2"/>
    <dbReference type="STRING" id="174720.A0A0N5C6R2"/>
    <dbReference type="WBParaSite" id="SPAL_0001362700.1">
        <property type="protein sequence ID" value="SPAL_0001362700.1"/>
        <property type="gene ID" value="SPAL_0001362700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000035">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF485">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE DAF-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="429"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="853"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="790"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001362700.1"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119854" checksum="A92BA8F2E0532E92" modified="2015-12-09" version="1">MVPSCENVNEGGEGAYILSKLYYSNKKLNSGVQGIEAFVGPTCSDDLQISSRIAKQLRLLEFNIWGEYGNEAFDNEIIQMSTESGTNIATNLYTILEILNWKKITLIYCDECMTRFKGKSFLSTEKNLILKTVKDILVANSITIKESLNVNEEQIKDFDYMSNLLSEAKNKARIFVPILGPTLDDYKTYMEASIANDMKTNNYMSIIFKLFQYPQPSDPWIMSDGSINETILELFDRTIVLKNDYYPQERISEFKTLYSLQSNDNSVLFYIQLFETAYTYMFMMTKAYIHSANNISLFSTPQYSTYLIDYMRNNKIDGPYGPIYFDNSNQRVSPYKIYSIEYSTTLKGYNNFMNVTINDNCISDTTDSCYKDNCLALKASIIDVNARILEDLPQDMPSCGFDGELCDQTGTIIIIVAVILTVLLVTLLFVFVRRMRTGETANMPWAIEADDLEVLDDDCHIIGSSGGIQSNLSMHSMHQQFESKVKMREILRNCYVGHIKGTGNVLVEPFQLTEKMAYDKQDMQLLFTLRQTIHDNINPFVGICIDNKNSEISFVWQYAMRGNLSSMLFNQQNKIIRDVDIGKDFTGAFVRDILKALDYIHSSSLHYHGGLTPANCWIDSHWILKVGGCCTLRMLFKWKSNNILTGKKDFPIIMNSDLHYYAPELRKAIKNKMNTNKAEKLEFTTLEGQKQDIYSFGIILYEMLFKKRVVEIDDSYNIQKNEDEDCGFFNVQAESLIPLYPTIPENHNDVHPDLISLMHKCYNGNASLRPDSNMARKITDATLKMPGSLVDQMIKNLEQYTNNLENLIEERTGQLEKEQQRAEQILLELIPKSVADDIKLGRKIEAKTYKYCTVMNSDIVGFTSLCSGILPMEVVNLLAGLAKNFDRIITENKCFKIETIGDAYVVSCGVPEPSKYNNVKNIANMTLQMKEFLLGYKVPHRPEKHLQCRFGFNSGPVFSGVIGLKAPRFCIFGHTALIASKMEQNGVPDRIQMTLRSFQLLSEKFPEFICVPRGGVRIEGVGTLLTYFLEGKDDSKVRTDLIPWDDTDISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C6Z5</accession>
    <name>A0A0N5C6Z5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5C6Z5"/>
    <dbReference type="WBParaSite" id="SPAL_0001371000.1">
        <property type="protein sequence ID" value="SPAL_0001371000.1"/>
        <property type="gene ID" value="SPAL_0001371000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001371000.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="60559" checksum="F1C5CD142725F337" modified="2015-12-09" version="1">XIYFMNASKSYSTLDILFDVINLSLLDVLCTYCALQQFIVNKSLHYVNFVSMPMEVESMMTKKEYLLGMCYDITILSNEKHCFLYFDSMVKMNMKRDKEIIKSDSNLLRKPFKIDLDCNKLIKGDIEYIDKVKNKRLVYKYNNLPMDCESIYKRGFNKYKILSSIEKKYSLAFAFNVYRNYEVIELKLLSIYSTNNHYCYMVDSKNPKLYHQMILLEKCLPNVYVPIVQYNMKSNGENTSISHFQCMKRLLKTKFDYVFLLQNDEMPLKTNRELIEILETMNFAMDMRITINKNIIKRRVDHKKSWKFKDLNIFLDGDIRKENATIMNQTIEFTKGLVTTGLPRDSVDYLLNKLNITTFLKQLNTHLYGNDELTWQTLLSSDILNVPGHVPRKHVMNYFPQPYYFSKLVVWSGAPCPTDSYHHGICSWGIENVKDLLNVRHYFLYRFKEDFDYGAMMCFGEYLYNKTNFEEYERPDLWFYYNSPSSIYKRLSLAHNMSLIEDYSRWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C758</accession>
    <name>A0A0N5C758_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SelT-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C758"/>
    <dbReference type="STRING" id="174720.A0A0N5C758"/>
    <dbReference type="WBParaSite" id="SPAL_0001377300.1">
        <property type="protein sequence ID" value="SPAL_0001377300.1"/>
        <property type="gene ID" value="SPAL_0001377300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895516" evidence="3">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001377300.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27313" checksum="7E04C902B19D64E8" modified="2015-12-09" version="1">MISKFGKVFLLFIFLLTIRDLLSSISSDKNIPDEEHDEFETFQHSNVDQEDEIDIRDPTSHLSPNHKDPDVVAIHSKKLPPVRFEFCVSCGYKQAFEQFSSVIREKYPNIEIHGENYPPVYWKSLTAHVVGIAKFAFIFLIISGKDPLLILGISLPSLSNWYMNNKISSCMMIFMLSNLIEGMMMSTGAFEIYLGDEKVWSKLESGRVPSPSELITILTQSLEINGVRGSNSFSQFNFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C7N5</accession>
    <name>A0A0N5C7N5_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C7N5"/>
    <dbReference type="WBParaSite" id="SPAL_0001394675.1">
        <property type="protein sequence ID" value="SPAL_0001394675.1"/>
        <property type="gene ID" value="SPAL_0001394675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001394675.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13431" checksum="A163A5BC968DDCC2" modified="2015-12-09" version="1">MNLIPVLKESHSCDRGILFLYGGNFIPVLEEFHSCDRGILFLYGGNFIPVLEESHSCDRGILFLYGSNFIPVLEESHSCNRGFFFLCGRNFIIVVEEFHSCVRGILFLYSRNKFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5C969</accession>
    <name>A0A0N5C969_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5C969"/>
    <dbReference type="STRING" id="174720.A0A0N5C969"/>
    <dbReference type="WBParaSite" id="SPAL_0001445200.2">
        <property type="protein sequence ID" value="SPAL_0001445200.2"/>
        <property type="gene ID" value="SPAL_0001445200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF27">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 71E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001445200.2"/>
        </source>
    </evidence>
    <sequence length="411" mass="45986" checksum="DD3856A01BD8C7D7" modified="2015-12-09" version="1">MPISKYRMVFCGYQGVHARFKDRLEKVKFGVPMACAFQSGDIPGPLLILLLKVNKEGPLRKDIWRAPGNQAQVKKIAAIMKGGRMMNISDINVYTAASIVKRFLSKLPGGVFGPENERLLFGILHEPDPTKQRAVFAKIIHAMDPVSQNFMVLLFGTFRIIADSSITFDTRMNPEAIGISVAPSLFHTCINDTKAKFDDVRKFKQASHIIAILINNFGYTDMFSRESYEYYAKITGRTIRVEENWMFSFQYPIKKKIGRRQNLGTSLGALNIHQNDLECESSDDNTTLPIAKRSTSASVVLNRSAIGAASVTGCVDPHHQPCCSCASAEKPLSLIFGKSLSPEDLGESHAIGNKSQSYSGPLKPHNKILTVKKTIIFNIIIISSVCMYCRFIFCIILYFLIFFPSYFFCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CA44</accession>
    <name>A0A0N5CA44_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5CA44"/>
    <dbReference type="WBParaSite" id="SPAL_0001477000.1">
        <property type="protein sequence ID" value="SPAL_0001477000.1"/>
        <property type="gene ID" value="SPAL_0001477000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001477000.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34511" checksum="7C243799396815E8" modified="2015-12-09" version="1">IESETCIRFTKSATPITGKPGLRYFKGSGCWSYIGRIYTDAPQEVSIGQGCGSNAIIQHETAHALGVYHEQSRPDRYLYVTIKTEDIIAGKESNFAGSIPGYVNEYGIPYDFGSVMHYGRFSFSKNGNQTIVAIDGKYDKTMGQRKKLSFNDVKLINFKYCNSTCPSTSISCKNGGYLDPNNCARCKCPLNFYGTYCQNYVTSPSTTCGSQMLTASTTIQTLKITGVKNCYFVIKASSGYVIKLNLVSSSLVKRDPCYSGGGLEIKHKIDKTATGINFCGVNSNQIFTSESDSVLIHYVGTTATDSFTLTYIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBL9</accession>
    <name>A0A0N5CBL9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 18a1 (inferred by orthology to a D. melanogaster protein)</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="STRING" id="174720.A0A0N5CBL9"/>
    <dbReference type="WBParaSite" id="SPAL_0001528600.1">
        <property type="protein sequence ID" value="SPAL_0001528600.1"/>
        <property type="gene ID" value="SPAL_0001528600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24284:SF1">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001528600.1"/>
        </source>
    </evidence>
    <sequence length="1345" mass="155908" checksum="62CA9C43F21C2F38" modified="2015-12-09" version="1">MIGVLLLLFIVFYLFNFYKNVKSLPPGPMPIPILGNLLSPDLDKIYLWVHEQKKIYGNVFTVWLPTPLVIFADYDSINEALVTNGDHFIGRNVDGYPEKAIHEKVNTGVIHSEGEEWRDQRRLSIQILRNFGMSKTIMQDKIHLVIQDFYEYLDNLENKDSVDIEKVIQLSVGNVINLILFGFMYNHSNCEKMFEFAKELEASFKSLNTLEFRLVMLIPAIDKIPILKDFIYKRLIKKQRKVAELTKIEIDECVKSYNPEDEPPNFIHAVMKEIQSIDSKYSYLNSDHLEGMVQDFWIAGMETSATTLKWFILLLMKHLDIQKKLQNEIDEVLGKDQLVQLTDKAKMPYMNAFISEGQRFINIVPFPPSHKCTKDSVINGHLIPKGTLTQPFYWGANMDKKYFKDPFDFNPDRFLDNEGKFVVENDHMSFGKGKRVCAGKSLADAEIFLFITSLLQKYNFTHPSGPVDTTPVFNGVLKVKSLPPGPMPVPILGNLLSVDLKNLHLWIHEQKKTYGNIFTVWLPAPQVVFADYDVINEALVTQGDYFIGRKVEGYPEKAFHEKFNSGVIFSEGEEWRDQRRLSIQILRNFGMSRTIIQDKIHLVIQDFYEHLDNLEDKDNVNIAKVIQFDEFFEFVKVLENSSKEFNSLDMKLLIMFPAIDNIPILNDILYKRIMKRNNKMRIHTKMQIDKCTKSFNPDDEPPNFIHAVMEKIQSIDSKYNYLNSHHIEGMVLDFWAAGMETSTTTLKWFILLIMKHLDIQKKLQDEIDNVIGRDQMVQLSDKAKMPYMTAFITEGQRYVNLVPIVPTHKCTKDTVINGHLIPKNTLTQPFFFGANMDEKYFKDPSVFNPDRYLDSEGKFRMENEHMSFGRGKRMCAGKSLAEAELFLFFTALLQRYKFTHPNGPVDLSCEFADLLIPKPYTSPQVVFADYDVINESLVTNGDHFLGRNVDGYPEKAWHEKTNTGVVFSEGEEWKDQRRLSMHILRNFGMSRTTIQDKIHLVIQDFYEHLDNLEDKENVNIAKVIQLSVGNVINLILFGFMYSHTDNGDFFKFAKDLDISIRENSTIEFKLLTLFPAIDNIPILNDFLHKRIVKKKSKVTNATKMQIDKCMESYNPDDEPLNFIHAVMKEIQTIDSKYSYLNSYHLQGMVQDFWAAGLETSTTTLKWFILLIMKHLDIQEKLQDEIDNVIGRDQLVQLNDKNKMPYMSAFIMEGQRYANILPVVPSHKCTEDTVINGHLIPKNTLTQPFFWGANMDEKYFKNPSVFYPDRFLDNEGKFKVEYDHMSFGKGKRVCAGKSLAEAELFLFFTALLQRYKFTHPNGPVDLSCDFADVLLPKPYTCKIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CBQ9</accession>
    <name>A0A0N5CBQ9_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CBQ9"/>
    <dbReference type="STRING" id="174720.A0A0N5CBQ9"/>
    <dbReference type="WBParaSite" id="SPAL_0001532300.1">
        <property type="protein sequence ID" value="SPAL_0001532300.1"/>
        <property type="gene ID" value="SPAL_0001532300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001532300.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="20619" checksum="900A5BB544A2AE12" modified="2015-12-09" version="1">MSGRGGFSRGRGNFRGGRGGGGGGRGGRNFDQGPPSNVEVVGSVTHSVDENTICVSNTSGKIPYFNAVIYNESIQQLGKVDEIYGGPKDNGFSVILSEGLKAKKFKKGDLVHIDPYKLLPIEKFLPGAQNNSSGGRGGRGGGNASRGRGGGGGNRGGGFKGNSRGGGRGGGSFGGNFGGNNQGFKRRGNFGSNGGNKKFRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CCB9</accession>
    <name>A0A0N5CCB9_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CCB9"/>
    <dbReference type="WBParaSite" id="SPAL_0001552900.1">
        <property type="protein sequence ID" value="SPAL_0001552900.1"/>
        <property type="gene ID" value="SPAL_0001552900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008569">
        <property type="entry name" value="DUF851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05867">
        <property type="entry name" value="DUF851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001552900.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47973" checksum="C687109D434C97C5" modified="2015-12-09" version="1">MNFFKNLGNKLPSVSKTSKKKKKLTQKEFSSITKVIDEERKRRKKRYQEAERKKIKKEKQNKLKKRMHRQKLCQKRSCCNSTVDSKENSTSVSLPPPNVLLQICKEKVLETKSDGDLSHSSKTVSCTQKEKKNTLQSTEKTQQQCISPNSGKSSNIENPTSEICRSSSNMQINSNHKKISKKPIRELIKEKNLHLNYKIDNNETKKKKKNFDSLGSCHTAPTCRTIDLQHPYYILNIKNDVLSNKLPYLHKENNNNNWNVYDSCGIPFWVPKLENEDDNTDDTTSDSIPLDSTSLIDVEQGKLELPECIDDPQDLNPFQPLRVMINRNPKYFENRTICLITLRSMAALHLKEAPSKTHESVVKDVQVSSVEITDNRELVCYPKYVPKGAFKTKYTGEVWPTKIVKPDEQQNDNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CF99</accession>
    <name>A0A0N5CF99_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CF99"/>
    <dbReference type="WBParaSite" id="SPAL_0001653668.1">
        <property type="protein sequence ID" value="SPAL_0001653668.1"/>
        <property type="gene ID" value="SPAL_0001653668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001653668.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="23250" checksum="A9E2D3C839DB9AFD" modified="2015-12-09" version="1">MLEISSRDITNFTNNTNKLAFEILDERGNLDYISFESGFPENKSSNSVIDLLALCWNKKNKFCMKNELEDLEFSDMDTELLRKRLYSRKIYRSFRNFGEKWRNLFSAHCSVIPPKTQRWLRSWCTCYRKLCCEECFMNNLKKLNELCLYHVIHKSDMFFSYIMDLQILGGYDTIGNHQIISLILNAFIKPKDRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CFU3</accession>
    <name>A0A0N5CFU3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CFU3"/>
    <dbReference type="WBParaSite" id="SPAL_0001672600.1">
        <property type="protein sequence ID" value="SPAL_0001672600.1"/>
        <property type="gene ID" value="SPAL_0001672600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005895869" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001672600.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="16973" checksum="5C0C7070DD21223A" modified="2015-12-09" version="1">MQFLFFILSTTAFFSAVQSNDEQHFPGLDFGLDMVKALSKDGVKDLVDVALQGQTGLGATVLKSVVSLMKNEPKAQETIKEHKDKKVHSAQGTGPSSAAAVKPLSDKAIDLLKKIEDIKKAGGSDEAQEKKIKDLVHEKDNKATFGEVSEFLKSALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CG01</accession>
    <name>A0A0N5CG01_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CG01"/>
    <dbReference type="STRING" id="174720.A0A0N5CG01"/>
    <dbReference type="WBParaSite" id="SPAL_0001677900.1">
        <property type="protein sequence ID" value="SPAL_0001677900.1"/>
        <property type="gene ID" value="SPAL_0001677900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="467"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="762"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001677900.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="106849" checksum="065B3C49ACA6FA23" modified="2015-12-09" version="1">MFLKEKLFIPFFVSIIISKYTYSFSFFSNYKKCKYSNDSNHRESLSLGVFLPHDYRKQIEPAIELALRHSHNTPNIIPDYCLNLIFKDTECKTSLGMKALFDLMSRNTKPVAVFGDVCTNVNEPVAMTSGHWDLLHLSYAETHSKFATADANELYPTFFRMVPGDRNVIATKCQMILHHNWRRVGTIKQADDARFSLAHESLTTKLENNYGIRVVYTAGLNLDELEKVSSELDELKSRDARIIIGDFDRHLAIKILCEAYAKEMYGRNYVWILTGYHNDTWWDVSFEDSNCTKEHVLKVLDGHFTIQFAMDRYDKKTKLVSGLTVKQTERELQKVCKNACKDNIFSKYAYDGIWTLVIALNKTLENEEDASIEFDRDTFLSQLHKSRFEGLTGKVGFENHERLGIINIYQFLNKSYHMFGYYNGIDDKLIILNITKKYKWTPPQDATIVVKERQYVSKILIWIMNIISIVGICIALIFLAINIRYRNHRFIKMSSPNMNNLIIFGSILAYISVILLGVDTRMVSSDNLVPFCHAKVWVLCIGFTLAFGSMFSKTWRVHSIFTNIQWNKKAIKDYKLFLIVACILAVDIIILGIWAYLSPFSFKIIDQPKILQNNLAIVPELEVCQSNNSLIFQLSLYGIKGLLMILGCFLAWETRHVNVPALNDSKYIGMSVYNIVVMSVLGVSLAVLLKEKVDEAYALSSFFIIFCTTLTLFFVFVPKIVELARHSDDQDTKVYRKGMLKSVVTKKSEQFKNSLKGNDIITETNKQKLERIEKENFELKNKLKELSLELWSLIEELKKQNFCSLHGSCDDKGLRFLYNDKEEETKQLLENSNSCEYDVSLRKEASILLDKGDNVKAKLLSDEENSLVESSNKIMANSKDGITVKDFSPVNEANISPQKKSSNIYTSTKKVNCDNSWPWLDPTQHITML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHB7</accession>
    <name>A0A0N5CHB7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHB7"/>
    <dbReference type="WBParaSite" id="SPAL_0001723600.1">
        <property type="protein sequence ID" value="SPAL_0001723600.1"/>
        <property type="gene ID" value="SPAL_0001723600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001723600.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11548" checksum="1DAF8357B7BE00C1" modified="2015-12-09" version="1">MAVAHERARQLRSFNESSDFCESKIISDSKITRRRKNSKRNAVPSGDTTVTDTFLSDNSLKAESARENGTFAEKENVSPGINEECSEDRFDDTLVLCKVTAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHF8</accession>
    <name>A0A0N5CHF8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHF8"/>
    <dbReference type="STRING" id="174720.A0A0N5CHF8"/>
    <dbReference type="WBParaSite" id="SPAL_0001727500.1">
        <property type="protein sequence ID" value="SPAL_0001727500.1"/>
        <property type="gene ID" value="SPAL_0001727500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001727500.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10732" checksum="7DB96A0AA681B6CD" modified="2015-12-09" version="1">MILNNLVKSTGATNFVIQSVRHNCPWHRSNFRPFYFPFHMNQKLKTGSFEARQKTYGGRLMIMRRVLREQPFLGWNHDARVKNQKLQTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5CHY4</accession>
    <name>A0A0N5CHY4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5CHY4"/>
    <dbReference type="STRING" id="174720.A0A0N5CHY4"/>
    <dbReference type="WBParaSite" id="SPAL_0001744600.1">
        <property type="protein sequence ID" value="SPAL_0001744600.1"/>
        <property type="gene ID" value="SPAL_0001744600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0001744600.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25539" checksum="5E0F258AD2F50B6D" modified="2015-12-09" version="1">MSGKHRYRGNEYGERNNNHHQQESADFSKIDNIIKVLSKCHVVVGLICLVLSALADYLSSTVQTLRFYGLQEVCSFYFVLLGIVGIVGAASRRRGIIIAFMIMSLHAILIFCPAIIITASFDIHFYQHECWGVCDWHLLTTNIGQDSKCQILCGASVDYQKRSTMTRLGTDYKLMAGLITAAIIELLLTIASALVCSQDIFKGHCNILSSSSLEETKSDNNLVELIPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B242</accession>
    <name>A0A0N5B242_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TORC_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B242"/>
    <dbReference type="WBParaSite" id="SPAL_0000014500.1">
        <property type="protein sequence ID" value="SPAL_0000014500.1"/>
        <property type="gene ID" value="SPAL_0000014500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000014500.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="26699" checksum="F8E759C5AE1E2957" modified="2016-05-11" version="2">MSGHSYSQQYTSISSHYQQSGHLPSTNGFPSTSSPSTNNSGNNPLHTSSSPSSVGNSLTNTSRNDDVVMNSISPSPSSSRSSHFMGSGNGGGNTSIHNTGNSCAINRQPNLQSDASGIPSYETGSGASSASSSHTRLTSNGDDSGVGSSHNLSHFEQIDHSTPFSHHTRNEDSFVHGIVRTPNNTEDLEPIERDRCNTWPLRRTAFDQNSNSPTVYDKIPEESDFCDSTENLPLDSVKQELNINSNLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B2U4</accession>
    <name>A0A0N5B2U4_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5B2U4"/>
    <dbReference type="WBParaSite" id="SPAL_0000039700.1">
        <property type="protein sequence ID" value="SPAL_0000039700.1"/>
        <property type="gene ID" value="SPAL_0000039700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP alpha-helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000039700.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36993" checksum="00F6B9816A478C45" modified="2015-12-09" version="1">MITNNNTLTSTEVKTETRDLIMPTENDRLIKKGKRSFELDNDFDLHQKRTKTMDMNIVKGNEEMSFFSGHNPVSPFYEINKNTSYEETSDQGCNDEDSIQHRFKIDITNFYDNISNDEENVNSYDTIECENGWNVLIDNYMGPYSVVIEEANNNNPTSRSDILQILKKDEVEQYTFLQRFEKEGHQPQSIYYTGTKEDLIDIFCCKFKEKTGQVYSEYRKKFGCQVFNEIEKDNNILISQPNVTIREILKMIFDIKNITQCLEEMSFNLEMVPLCDLSKIPIKNASQCLDRIILAAREEDVPVLMEEIDKYYRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3Q2</accession>
    <name>A0A0N5B3Q2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3Q2"/>
    <dbReference type="WBParaSite" id="SPAL_0000070500.1">
        <property type="protein sequence ID" value="SPAL_0000070500.1"/>
        <property type="gene ID" value="SPAL_0000070500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000070500.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="22117" checksum="AA24C8691EBE9687" modified="2015-12-09" version="1">MMTSKEPTLNDEFFHLRLFLRYKYYYAMERFTSYWDHGIYEVAILHLMHSLKAFEAEKNTINFMEGNCVELENMYNDLKLYIDKFLKLYNVEEEMEKKSLTCPNDCKFCYYKTILYDDENDTDLENDFLQKDEIYDIPLLTVYNCAKQIKKINEEKEEFPKQKVVYNENSIFKKFKNIFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B3X8</accession>
    <name>A0A0N5B3X8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B3X8"/>
    <dbReference type="STRING" id="174720.A0A0N5B3X8"/>
    <dbReference type="WBParaSite" id="SPAL_0000078000.1">
        <property type="protein sequence ID" value="SPAL_0000078000.1"/>
        <property type="gene ID" value="SPAL_0000078000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000078000.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39775" checksum="CEDAC8BA08DB284E" modified="2015-12-09" version="1">MDRKRKRSDISNDVSCDIETKVNKFNIVCTIPNFSQRPEKTGIPIESPSCVIGSQDRSQWCLWVYPNGRDEDSNEYVSVFLMLEQPDKAKVKYGFSIINDKGEEENVRSVKKSNNCVKDVCWGFSKFVRRDLLLNNKLNDLLVNDKLTISCEVEIIDPNTSETSANTTISQSKLPLDCGDMFELPFFTDCVIKAGDTEFKAHKVILSARSSVFFDIFKNTLEESQTSVIESKNFRGEVVKEMLRYIYKNEVLNIQNMASDVLAIAEKYKLDGLKAMAVKSLCDDLSTENVCKRFILSEKFSSECLKEFCQTFIIDNAESLMGTGNWEELAENHPLLVESLFLKSLNIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B4S7</accession>
    <name>A0A0N5B4S7_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B4S7"/>
    <dbReference type="STRING" id="174720.A0A0N5B4S7"/>
    <dbReference type="WBParaSite" id="SPAL_0000107600.1">
        <property type="protein sequence ID" value="SPAL_0000107600.1"/>
        <property type="gene ID" value="SPAL_0000107600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000107600.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="53212" checksum="A494D42735925FA3" modified="2015-12-09" version="1">MANYDDIGIPMDENEIHWTFSQIKGTSNDTESPEADIISAVQFSEDGELLATGDKGGRLVVFQRGQRNVYVKGIRSSEYNVYSTFQSHEPEFDYLKSLEIEEKINQIKWMKRRNAANFLLATNDKTIKLWKLSEREKRVKDVNWNISPFNGNKDYLRNGLMVPKLEQMELVIEASPRRVYANSHTYHINSISVSADQISFISADDLRINHWHHEYTKETFNIVDLKPNNMEELTEVITVAEFHPKNDSEFVYTSSKGTIRLCDMRDRALCDGHAKIYEEPEGSQGKSFFSEIISSISDAKFSHNGQFLMTRDYLTTKIWDIRMERRPVETYHIHDHLRSKLCNLYENDHIFDKFEVAWSGCDNHIITGSYGNVFRTFLRTSGLECTYAVANTSDRPRLSMTSRHISNGGIFRYLSDAEANSINFNKKILHLDWHVNENIIAMAAANNLYIFQGMQGIFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5E7</accession>
    <name>A0A0N5B5E7_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5E7"/>
    <dbReference type="WBParaSite" id="SPAL_0000129000.1">
        <property type="protein sequence ID" value="SPAL_0000129000.1"/>
        <property type="gene ID" value="SPAL_0000129000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000129000.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9309" checksum="76ACF4EEE85C2DA3" modified="2015-12-09" version="1">MPTTTVGKVTYYDNEPDETMDMFHSERISNKLAYSSIQSTMPNFVKTTNCPVVLMIAPATVICQQNDTIFGEMLGKLNINNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5L2</accession>
    <name>A0A0N5B5L2_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5L2"/>
    <dbReference type="WBParaSite" id="SPAL_0000135600.1">
        <property type="protein sequence ID" value="SPAL_0000135600.1"/>
        <property type="gene ID" value="SPAL_0000135600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893986" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000135600.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17117" checksum="39AB64CBF2547201" modified="2015-12-09" version="1">MNLKYLFFVLTILCLSQCLRAGKKCSFAYSLSGKINGKKGNFKDTKSEGVCEEQCVKMTGKFKADEDNYINGEINACMLKSACDKYKEGTETIDKAYDLLYEGYTHGKDIADFRKVLAAYAKNPLTSATREKMKGSYKIKCCDGDLCNKGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5R4</accession>
    <name>A0A0N5B5R4_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5R4"/>
    <dbReference type="STRING" id="174720.A0A0N5B5R4"/>
    <dbReference type="WBParaSite" id="SPAL_0000141000.1">
        <property type="protein sequence ID" value="SPAL_0000141000.1"/>
        <property type="gene ID" value="SPAL_0000141000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF185">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000141000.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36235" checksum="2481C42226CE57E0" modified="2015-12-09" version="1">MNTPQNIFYNHFEGNGTASSPDSGTFSVFDNFQQTRENGRLFNERQKVSFDNTIVGGNKTVNVSNGTQTTTSSSSSAVPKNPKLYKTELCRSWMDSGRCNYGERCQYAHGEHEKRPIPRHPKYKTEACQSYHKRGYCPYGPRCHFIHNEDNLISTQNIPATNNNITQLDSSNLMINLGNMTTTTNGSSVNRSSSSGDSPAPSSAESGSESPLGSYSPPLEQEDYFQSFSTTQNGRGKNPHDSEYNYDWTTMTPLINDFNAWGIGPNQQLQSNRGMHSFDQFSLGVNPFTNNGFSSFANSDNDSTNDYGSVFGAERLPVFEQLANASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B5T0</accession>
    <name>A0A0N5B5T0_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B5T0"/>
    <dbReference type="STRING" id="174720.A0A0N5B5T0"/>
    <dbReference type="WBParaSite" id="SPAL_0000142500.1">
        <property type="protein sequence ID" value="SPAL_0000142500.1"/>
        <property type="gene ID" value="SPAL_0000142500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059031">
        <property type="entry name" value="SH3_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26085">
        <property type="entry name" value="SH3_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAC3-related SH3" evidence="1">
        <location>
            <begin position="119"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000142500.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21084" checksum="9E1D9F50ED28F14D" modified="2015-12-09" version="1">MEDITSTDIDEYGAPIRRFEKKVRFTNLQSSEGIRKRFNSPYRPIEKEVLYNDLSKRQVVSYCATHDVRPYNSDLIIPKGLSIKAYDQGDPNWYWGMAYDGRSVTKTYLPKSSVSPVYKNETIMSVRKNICLSKESMTLYRGQIVFVQNNSLSIDKKLTIRTETNKLVNCRLSFLEFPQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B646</accession>
    <name>A0A0N5B646_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B646"/>
    <dbReference type="WBParaSite" id="SPAL_0000153500.2">
        <property type="protein sequence ID" value="SPAL_0000153500.2"/>
        <property type="gene ID" value="SPAL_0000153500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF4">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000153500.2"/>
        </source>
    </evidence>
    <sequence length="320" mass="37397" checksum="CAB8D0F86FDB1CB8" modified="2015-12-09" version="1">MSHNDTLQKNDAQQDRMTNENIQIIVTVISSILFFRLATYIVRWYFFKNLLFKTRNYFESTKKSKEDGTYFAHVQHNKKWRISNECISCFHAFICSIWLFFNIIHYFDTSINNESLYVHSFGLMFMMIFGYIISDSIDMLANERSIRVYVLIFHHTLVAIGCLYPVILKHFGGIVIIGFLMEVNSIFLHIRSLLNYSGYSKARLSFKMLAFINILTFILFRFIPNLYLIYFIIVITNNVPWYETFACCLVSVGLLTTNTVLFYRLLVADNFLTIRKRNPVDFEEQSLLDHNNQLSIPTTPFLTAPTTPETVTIGTQTINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B648</accession>
    <name>A0A0N5B648_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B648"/>
    <dbReference type="WBParaSite" id="SPAL_0000153700.1">
        <property type="protein sequence ID" value="SPAL_0000153700.1"/>
        <property type="gene ID" value="SPAL_0000153700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14383:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14383">
        <property type="entry name" value="SWAP-70 RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="147"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000153700.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="67714" checksum="E80961A7B9F43B31" modified="2015-12-09" version="1">MTLIRNNLQHKNSMTSSIYSGDTFKKRLAPSIYDNFLTNYGDLEIKNMPDYVNVPSDYHKTTLVANKGFFRTEDSTINHITSNKHNSNVKDKHGILRSLSFQFSPFRGTKVVDTIPSQKNGIIPGKISRDTTSKQSNELGEVGPLLGVQMYGCLLKKYKKKNRPVKWKKRFFILKECFLLYYSCRVKKEFESTRRINLHPKGIIPLIGCSIISGGDVGKRYCLLITHCQFDSAIIVCATDIKCQENWFKALREATKISYKNTLYGEHIIRELESKGNILNEEKRSIEEKLQQEAIARQEEKERNFELEKTREELEKEREKLVKLTMKMKEDISKIKNDLDQTSDAKYKLENEKIMLLTKTEHLVTNMECLNLEKTKIEDQMNQILQEREKFLLENQNLSSVTCQLKNKMQEIENKTTKIATEKEKIECLMKLNEQKTLELEKERAVYNRQTKELLQNLKIISEQKEMTEAELKDEVIARIGAERQLYAAEKALEHLENALKLTGAQMAELQEHIMPDVHKLREFFEKCAIDAKLEAQKSLIMRNAIYARRSFRKNPVKSRSKSNFKRHVSMKEERKSIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6B6</accession>
    <name>A0A0N5B6B6_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exocyst complex component Sec10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6B6"/>
    <dbReference type="STRING" id="174720.A0A0N5B6B6"/>
    <dbReference type="WBParaSite" id="SPAL_0000160600.1">
        <property type="protein sequence ID" value="SPAL_0000160600.1"/>
        <property type="gene ID" value="SPAL_0000160600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="161"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000160600.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="83033" checksum="1E7FFF5EB2690DF1" modified="2015-12-09" version="1">MSGQQYFATYVQDLEQDPFDVTDFVERLAWRINGNTDTIDVEKLKAKFEEEIGSLQLLSDQFQNKITILDSQLKTSRQIYQQSLHEANEQNSLILDKLKKLDNTMQEVSTKIVHLGDQLESVNAPRARALEALQLIKHFDEFLADQPLTSAVFTDPERLMESAEIINKLYSISQELDNKKFSKTQQRISNKYDEIQEMLIDEFIKTFERKENFNRKEMREITNVLSNFNRYNVLLDKFVERVENTSYRGNNVFNDILEMCEKKASLIDEIFPNSSVVMSKLILNAYQRRLNDEVQMKLEHLRQEDNEQYLLTLNDLYTRTLKLNEKLQNFKYRQDTQFISMITSSIFDKYLKLYEKTEEEFVTVQCNGILQRFYSSKGHQKRNLQSGGLQELRRDLTAILRTVENFGDETFLSEEVAINILQELKNAFSRCQKLASPSKKSELMKILYELLVKFLYHEHVLYAIELALSGIPYSEPRTEPSSIFFAVVQQSSAITHLFVKQFDDSIISFLDLKNIRDECVKAKDSTLRLLETRINVGIEKQLNAITGYVKYTLNNEQKKTDFKPDDEDQHDNINITPACENVCRYLNSQYNIIKESIDGGNLLTILKDLGIRVYQIIFGHIKNYNYSISGAMLLLCDLNEYRKTLGSWKINEVNKKMESLHALANLLVVVPENLEQACNSPLVSEYTPDVINSIILLRHDSKTIVKYLHFLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B6M8</accession>
    <name>A0A0N5B6M8_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5B6M8"/>
    <dbReference type="WBParaSite" id="SPAL_0000171600.1">
        <property type="protein sequence ID" value="SPAL_0000171600.1"/>
        <property type="gene ID" value="SPAL_0000171600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35573:SF3">
        <property type="entry name" value="ML DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35573">
        <property type="entry name" value="PROTEIN CBG22129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005893861" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000171600.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21467" checksum="5065028C65CB8F12" modified="2015-12-09" version="1">MKTFILIAITVSIAYSFALPKLPTSRKVCPFPNATDTAIHFFNCDSNMPLTMISGKIKTESGQEMYPIDPTKPMTLELTAQNNGVQINDNHVKVNIYEYTTNWLTGKCSWVEVPTFGLISNIDGCEYAHNCPLVKGPLVLSLPLDLSGYSSIIELIAGKNPYQLVIRMYNYNEGDSKHEEFACVTSQLRFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5B719</accession>
    <name>A0A0N5B719_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5B719"/>
    <dbReference type="STRING" id="174720.A0A0N5B719"/>
    <dbReference type="WBParaSite" id="SPAL_0000185000.1">
        <property type="protein sequence ID" value="SPAL_0000185000.1"/>
        <property type="gene ID" value="SPAL_0000185000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000185000.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="36365" checksum="9CEB64FB27CE4C7B" modified="2015-12-09" version="1">MVKNRLPEFNEYSFNLRAPSVIETPKSSRYLINDNRNNELNKMFTSIATIRNYMLRMETILEIVPEKQSEILLKPGINENINATLNTLNEEFKDLTKVCMDQIKLWNKEIKNIPNNNLTAIQRIKKNQIISLNIKMENLLSRYNNYQMTYRDKVIKKMTAYYKSLNSMITEDEIEEFIITGNLNKLSELAILGKNNKEEVLDNIRNRNEHINKLEKNICQLHDLYHDLMILTELQGDKVDYISKEVEKTSCDVEKANENLISLKKKKINSIKVSKFILIIYFLVLHNFLWYWNVNYFIFNGICNKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BA71</accession>
    <name>A0A0N5BA71_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BA71"/>
    <dbReference type="WBParaSite" id="SPAL_0000294000.1">
        <property type="protein sequence ID" value="SPAL_0000294000.1"/>
        <property type="gene ID" value="SPAL_0000294000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000294000.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28813" checksum="C5A60A3070B1271D" modified="2015-12-09" version="1">MSYYRKEVLMNTFSKSSPTRQFRLFAGGETFYVNGYYLAELSPYFETLFFNEFFTEARTKTVSFTSVDWQELHVFLEYLCPVSRMRDKREITVDNFHILIYFSNRFLIREIEYPLIQFVKDNFDACRVKFSCSKLLVMSSYLISSNSPKEFLQFCYESIALYPEKDVMACSNIISGRDMKCILEECTRIRRRIMECQLDKTQDDYDIRDEHLRGIINCTDNITNYFFGAFIAILIYFVWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAB3</accession>
    <name>A0A0N5BAB3_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAB3"/>
    <dbReference type="WBParaSite" id="SPAL_0000298300.1">
        <property type="protein sequence ID" value="SPAL_0000298300.1"/>
        <property type="gene ID" value="SPAL_0000298300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000298300.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12598" checksum="B2D9EC309CFD33CC" modified="2015-12-09" version="1">MKGRILCNKRSLSNVTVELMEEDVFYDDTLNKGKTDVNGYFSLYGRDEEFTVIEPYIKISYICPILNESKSVNTMLLYPPDTLLKSYSHYSEYYYNFGEIDLYKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAF1</accession>
    <name>A0A0N5BAF1_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BEACH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="174720.A0A0N5BAF1"/>
    <dbReference type="WBParaSite" id="SPAL_0000302100.1">
        <property type="protein sequence ID" value="SPAL_0000302100.1"/>
        <property type="gene ID" value="SPAL_0000302100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="238"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000302100.1"/>
        </source>
    </evidence>
    <sequence length="1425" mass="164142" checksum="7B0B1B55A1108E24" modified="2015-12-09" version="1">MDRLTTLSLADKAKTLSSGNHTITVNDVPYHIKIESLLLSIDSNKNIKKMMFDYFTHIMNNSAKEGICENKIIQLTHNETKCHENLFSPTDSIFELSKHLSISWYDDTINDENLKFLWRPLSTQTQLFPLICIIKTTKEYLFVNLVDHEFIYNVKKISLFSHQNYDIFSQQFHLIICQMLNIFYSLSKKGIFPVYSLNNFIANSNLWLQLNLIDIISSISNDYIDLEKKTASSSVIVDINENSCALEEITKLWKHRKISNFDYIMKLNEFSGRSKDELNYYPIMPWVCDFTSKTGGWRCLDKTKYRIVKGDDQLKEQYNRLPSHHIPELLSDICVMSYRARVESKEKLCQIVRRKWEPNEYPRSIEKMYSWSPDECIPEFYIDPKVFCSVHEDMNDLELPYWAKTGEEFIKWHKDMLESEEVSENLHKWIDLTFGYLLTGKNAVDALNVHLSYIRKTDDMIRTHGVVQLFTSPHPKRFRQSMIGEIIEFLPLYNDYLPNDENLSVYKEGETFNLKKLLADIYSSKDFVPSYVENSLISIAVCIIELCLSENCRDLLDNAPFEKRLKRARFLFNDCFYKLPRNLTSTLKKFLFNNIPSTITNNPLELQNPLINHFNLSESAYVANLLLLRYYSIKYKWKISVIRNEKEKSKELIKNQVDILWELIGIEGLDLLWINLFISLISINEHALSVCFLLFSRITTCNKIHHPKLIDAVKKLFDDFDLQHDPSIIKLLDRRFLLQLCIRFGTRIFTKTFLKPIVKKILYSSDPGVITVAKESSIWLAKRFGPIITVSILIPELLKLFEHCYTKTEDIFEVNLDVVGNGDENVCNITDVLVEIIVMYGPSIIVNCFIPFFKQTFLQISTQRLLQSQESLIISSNHFLSIMCNCLFDNQLMDNLNIIINDILLPAVKILTSSVITFSSTSSRRLYASKLLKWLHLLSYRIGLENVQRFMQHIIQQLFCNFPLIYSFNEIEGIVADTKNTTPQLLSIFDAKFAKLCLHIFSQICGNRFIQYSLPDSQLIIRLAGGKPSLLSTSLSSTSFSSSPGASFLESQMNPLKSYNSVENSSETINLPSHHSTASGTNLYDRISNESYSQLTNNYVLALEKIIESSPSSVDFHQIPLSTYQGHQGSIKKICIMDNENCFISASSDKTIKLWSIKSSEDISQCQWSYKNHSKSLYDASIIANGGLIASTDGILNIWDPFKGCTLSTLDWYKTGNKQCVPITNLSPLTNYTMCLSSTSDVLIKLCDVRIGNYIYHISPVNITNNSSQYNVKAMALSQCESKIVASLYNGSIVLCDIRTGKIISLSMQSHSDCYQIEWISGTMFACLFTDHHTSIWTIYPRLRLLNKLTENATTIIPENFYVSKQFMTLHSMNRVKIYTDNETCEIEKKIRSDEIASIVCAGARLCMNKMWLFGTSNGIIKLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BAJ6</accession>
    <name>A0A0N5BAJ6_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A0N5BAJ6"/>
    <dbReference type="STRING" id="174720.A0A0N5BAJ6"/>
    <dbReference type="WBParaSite" id="SPAL_0000306300.1">
        <property type="protein sequence ID" value="SPAL_0000306300.1"/>
        <property type="gene ID" value="SPAL_0000306300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF27">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005894078" evidence="9">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="43"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000306300.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46560" checksum="902B14AEE2FEC56A" modified="2015-12-09" version="1">MDLKMNFILILLLSFSQTILSARSYQGSTNALDNAVTGEPIVECLEDRVKLTFRTEKPFGGRIFVKGMIDSQECVKTFNGNSKNAIDFEVLNGECNMRRSRKIGPDQRGVEQAVTVIISFHDTFITKVDKAYRTTCFYMETDRVVTNSVDVSALPTTEITDTAKMPICTYSVRRGSVTGAIVTYATVGEPVFHVWECDSDMFSMLVHSCFVDDGDGNSRKTIIDEHGCSTDTLILPELTYNQQNNMAYSEVNVFKFADKVTTYFQCAVSTCMISEGMCVGRTPPKCTSATLTSRNRRSLENKRITAVIRNSPENSTIDDPFTMDLSADKIVVLDLDDAQAKRIGNLINPEKAILSTLGNQDKFETVSSIQNEASQLCISHNMIIILILLSSCTLSVASAILVAFFLKLKRQESVTFTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BB62</accession>
    <name>A0A0N5BB62_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="SPAL_0000327200.1">
        <property type="protein sequence ID" value="SPAL_0000327200.1"/>
        <property type="gene ID" value="SPAL_0000327200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000327200.1"/>
        </source>
    </evidence>
    <sequence length="40" mass="4756" checksum="12362F27CCF78A2B" modified="2015-12-09" version="1">XLNTRRATYSNVWGVLRGPPCIFIYHHHLFYILALSEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BC38</accession>
    <name>A0A0N5BC38_STREA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A0N5BC38"/>
    <dbReference type="STRING" id="174720.A0A0N5BC38"/>
    <dbReference type="WBParaSite" id="SPAL_0000358700.1">
        <property type="protein sequence ID" value="SPAL_0000358700.1"/>
        <property type="gene ID" value="SPAL_0000358700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000046392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="SPAL_0000358700.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44441" checksum="3B8AFFA0750A54C4" modified="2015-12-09" version="1">MFSVKIEVEQLLKNLDDETNSLKNSLCDFKKVSNNLISNLEVLIDDNMRKNEKNGTNKVDSSLKHSLDSFSEIITRAINRQVEDHKDMHQNLSKLGKIIDKQFIDDYNGLINNQEDIYDDDELSECTNQLVHEHLLSTGDIDAAELMTKETKFDPDGPDYSELYHVETIANDICQFEIENALNYLLHKHKDETELIKDFKRLLALQYVEQGKKADAVRLTKEIASLSNSEEIDQVKELMTKIMSYPNCKNWESYRSKEHYQELASRFAKVAVGLPEPLQKVVETGVDLFPTFMNTRELMKARGRNISEANELPIDAADQDEPQHSVFICPVLKAASDFSNLPVRLNCGHVVAKDALDRMVVTNRANKIKCIYCPKESYKDEAKPLYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N5BCK3</accession>
    <name>A0A0N5BCK3_STREA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-hexosaminidase</fullName>
            <ecNumber evidence="8">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Strongyloides papillosus</name>
        <name type="common">Intestinal threadworm</name>
        <dbReference type="NCBI Taxonomy" id="174720"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Strongyloidoidea</taxon>
            <taxon>Strongyloididae</taxon>
            <taxon>Strongyloides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A0N5BCK3"/>
    <dbReference type="STRING" id="174720.A0A0N5BCK3"/>
    <dbReference type="WBParaSite" id="SPAL_0000375000.1">
        <property type="protein sequence ID" value="SPAL_0000375000.1"/>
        <property type="gene ID" value="SPAL_0000375000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000046392">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
 
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